locus-tag class description HPC72_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HPC72_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HPC72_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HPC72_RS00020 ENOG4105K7N UPF0232 protein HPC72_RS00025 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPC72_RS00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPC72_RS00085 ENOG4108U4N (sortase) family HPC72_RS00095 ENOG4105D9P serine threonine protein kinase HPC72_RS00100 ENOG4107TPY serine threonine protein kinase HPC72_RS00105 ENOG4105CJN penicillin-binding protein HPC72_RS00120 ENOG4105HZM Fha domain containing protein HPC72_RS00125 ENOG4105TV9 FHA Domain-Containing protein HPC72_RS00145 ENOG4105D22 carbon starvation protein HPC72_RS00155 ENOG4107QTF adenylosuccinate lyase HPC72_RS00160 ENOG41082T9 Membrane HPC72_RS00180 ENOG4105CIH Imidazole acetol-phosphate transaminase HPC72_RS00195 ENOG4105KME endoribonuclease L-psp HPC72_RS00210 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPC72_RS00220 ENOG4105C4Y ABC transporter HPC72_RS00225 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPC72_RS00230 ENOG4105BZU Histidine kinase HPC72_RS00275 ENOG4107TE5 Lipid kinase HPC72_RS00280 ENOG4105C5Q Transcriptional regulator HPC72_RS00285 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HPC72_RS00290 ENOG410667J hydrolase HPC72_RS00300 ENOG4107QKS N-acylglucosamine 2-epimerase HPC72_RS00325 ENOG4105C28 cystathionine HPC72_RS00360 ENOG4105WH1 Two component transcriptional regulator luxr family HPC72_RS00385 ENOG4105DF6 Fe-S oxidoreductase HPC72_RS00405 ENOG4108UCS ABC, transporter HPC72_RS00495 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HPC72_RS00500 ENOG4105CFH Aspartokinase HPC72_RS00510 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HPC72_RS00515 ENOG4105D52 delta-aminolevulinic acid dehydratase HPC72_RS00525 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HPC72_RS00535 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HPC72_RS00540 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HPC72_RS00545 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HPC72_RS00550 ENOG4107JTW chlorite dismutase HPC72_RS00555 ENOG41080RH Thioredoxin HPC72_RS00655 ENOG4105EC2 ftsk spoIIIe HPC72_RS00675 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HPC72_RS00680 ENOG4105CC5 ABC transporter HPC72_RS00690 ENOG4105DIK (ABC) transporter HPC72_RS00695 ENOG4107SIG periplasmic solute binding protein HPC72_RS00710 ENOG4107TE5 Lipid kinase HPC72_RS00720 ENOG4108PSK reductase HPC72_RS00730 ENOG4105BZ4 penicillin-binding protein HPC72_RS00745 ENOG4105IJJ transcriptional regulator, crp fnr family HPC72_RS00755 ENOG4105CPT Alpha beta hydrolase HPC72_RS00765 ENOG4108UMN azlc family HPC72_RS00815 ENOG4105D3R alkyl hydroperoxide reductase HPC72_RS00825 ENOG4105BZU Histidine kinase HPC72_RS00830 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPC72_RS00845 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HPC72_RS00865 ENOG4105CSH Transporter HPC72_RS00885 ENOG4105DBV ornithine carbamoyltransferase HPC72_RS00890 ENOG4105CEU Arginine dihydrolase HPC72_RS00900 ENOG4107QRG dna polymerase iii HPC72_RS00910 ENOG4105HDK L-asparaginase HPC72_RS00930 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HPC72_RS00940 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HPC72_RS00950 ENOG4105K8R UPF0145 protein HPC72_RS00965 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HPC72_RS00975 ENOG4105CQ7 ATP-dependent helicase HPC72_RS01005 ENOG4105EN6 Membrane HPC72_RS01035 ENOG4108ZF3 Phosphatase HPC72_RS01060 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HPC72_RS01120 ENOG4105DHP deoxycytidine triphosphate deaminase HPC72_RS01145 ENOG4108DBC nitroreductase HPC72_RS01155 ENOG4105EMU Dehydrogenase HPC72_RS01165 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HPC72_RS01185 ENOG4107RCW fructose-bisphosphate aldolase HPC72_RS01210 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HPC72_RS01225 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HPC72_RS01230 ENOG4105C12 Phosphoribosylglycinamide synthetase HPC72_RS01235 ENOG4105C8V SAICAR synthetase HPC72_RS01250 ENOG410839H phosphoribosylformylglycinamidine synthase HPC72_RS01255 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HPC72_RS01260 ENOG41088YS Glycosyl transferase (Group 1 HPC72_RS01265 ENOG4107QIK phosphoribosylformylglycinamidine synthase HPC72_RS01280 ENOG4105D82 Glutamate dehydrogenase HPC72_RS01285 ENOG4105E98 transcriptional regulator DeoR family HPC72_RS01290 ENOG4105DE4 1-phosphofructokinase HPC72_RS01295 ENOG4105DM4 PTS System HPC72_RS01305 ENOG4105JXH GntR family transcriptional regulator HPC72_RS01320 ENOG4105CXB phosphoribosylaminoimidazole synthetase HPC72_RS01350 ENOG4105BZ1 (ABC) transporter HPC72_RS01355 ENOG4105BZ1 (ABC) transporter HPC72_RS01410 ENOG4107AQZ Membrane HPC72_RS01415 ENOG4105C1J atp-dependent rna helicase HPC72_RS01455 ENOG4107NHD transcriptional regulator HPC72_RS01465 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HPC72_RS01480 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HPC72_RS01510 ENOG4107RA4 Glycosyl transferase (Group 1 HPC72_RS01520 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HPC72_RS01565 ENOG4105K6V RNA polymerase HPC72_RS01575 ENOG4105R3P Inner membrane protein yagU HPC72_RS01580 ENOG4107SIQ Naphthoate synthase HPC72_RS01585 ENOG4105CEU Arginine dihydrolase HPC72_RS01595 ENOG4107TCW O-succinylbenzoate synthase HPC72_RS01600 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HPC72_RS01615 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HPC72_RS01620 ENOG4105P52 geranylgeranyl reductase HPC72_RS01630 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPC72_RS01635 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HPC72_RS01640 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPC72_RS01650 ENOG4107QIZ NADH dehydrogenase HPC72_RS01655 ENOG4108IEH NADH dehydrogenase subunit g HPC72_RS01660 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HPC72_RS01665 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPC72_RS01675 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPC72_RS01680 ENOG4105D65 subunit l HPC72_RS01690 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPC72_RS01705 ENOG4105DSE periplasmic solute binding protein HPC72_RS01715 ENOG4105CC5 ABC transporter HPC72_RS01720 ENOG4105FDK ABC transporter HPC72_RS01735 ENOG4105D0M Protease HtpX homolog HPC72_RS01740 ENOG4108VPT UPF0234 protein HPC72_RS01760 ENOG4105WDJ 50S ribosomal protein L33 HPC72_RS01775 ENOG4107WR6 Maf-like protein HPC72_RS01780 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HPC72_RS01790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPC72_RS01795 ENOG4105BZU Histidine kinase HPC72_RS01805 ENOG4105DQR SNARE associated Golgi HPC72_RS01835 ENOG4105ETE Transcriptional regulator (LacI family HPC72_RS01865 ENOG4108KGH TRANSCRIPTIONal HPC72_RS01915 ENOG4105MFV ABC-2 type transporter HPC72_RS01920 ENOG4105EY8 ABC transporter HPC72_RS01935 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein HPC72_RS01955 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HPC72_RS01965 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HPC72_RS01970 ENOG4105KPE licD family HPC72_RS01975 ENOG4108SHN Glycosyl transferase, family 2 HPC72_RS01985 ENOG4105KPE licD family HPC72_RS01990 ENOG4106MCE EamA-like transporter family HPC72_RS02005 ENOG4105EIP mannose-6-phosphate isomerase HPC72_RS02015 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HPC72_RS02055 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HPC72_RS02060 ENOG4108WQ6 secreted protein HPC72_RS02075 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPC72_RS02080 ENOG4105BZU Histidine kinase HPC72_RS02090 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea HPC72_RS02095 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HPC72_RS02100 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HPC72_RS02140 ENOG4105C2J ABC transporter HPC72_RS02145 ENOG4105CNN ABC, transporter HPC72_RS02150 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HPC72_RS02155 ENOG4105EYH Exonuclease HPC72_RS02160 ENOG4107RH8 nuclease SbcCD subunit D HPC72_RS02165 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HPC72_RS02170 ENOG4107TK4 histidinol-phosphate phosphatase HPC72_RS02175 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HPC72_RS02205 ENOG4108IUE nitrate reductase beta subunit HPC72_RS02220 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HPC72_RS02230 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HPC72_RS02240 ENOG4108ZAF Molybdopterin HPC72_RS02250 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HPC72_RS02280 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HPC72_RS02285 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HPC72_RS02300 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HPC72_RS02305 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HPC72_RS02310 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HPC72_RS02320 ENOG4108ZF3 Phosphatase HPC72_RS02330 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HPC72_RS02335 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HPC72_RS02340 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HPC72_RS02345 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HPC72_RS02360 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HPC72_RS02365 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HPC72_RS02370 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HPC72_RS02375 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HPC72_RS02380 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HPC72_RS02385 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HPC72_RS02390 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HPC72_RS02395 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HPC72_RS02400 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HPC72_RS02405 ENOG41082SA 50s ribosomal protein l29 HPC72_RS02410 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HPC72_RS02420 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HPC72_RS02425 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HPC72_RS02430 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HPC72_RS02435 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HPC72_RS02440 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HPC72_RS02445 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HPC72_RS02455 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HPC72_RS02460 ENOG410849U 50S ribosomal protein L30 HPC72_RS02465 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HPC72_RS02475 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HPC72_RS02480 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HPC72_RS02485 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HPC72_RS02490 ENOG41067V7 50S ribosomal protein L36 HPC72_RS02495 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HPC72_RS02500 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HPC72_RS02505 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HPC72_RS02510 ENOG4108ZT0 50S ribosomal protein l17 HPC72_RS02525 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HPC72_RS02530 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HPC72_RS02535 ENOG4108UJD 30S ribosomal protein S9 HPC72_RS02545 ENOG4105CS9 pantothenic acid kinase HPC72_RS02560 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HPC72_RS02565 ENOG4108097 ATP-binding protein HPC72_RS02595 ENOG4105E33 succinate dehydrogenase HPC72_RS02610 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HPC72_RS02630 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HPC72_RS02635 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HPC72_RS02650 ENOG410849S phosphocarrier protein (HPr) HPC72_RS02655 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HPC72_RS02660 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HPC72_RS02675 ENOG4107QP6 Xylose isomerase domain protein TIM barrel HPC72_RS02685 ENOG4107P2S Transcriptional regulator HPC72_RS02695 ENOG4107QNK )-transporter HPC72_RS02705 ENOG4105ETE Transcriptional regulator (LacI family HPC72_RS02710 ENOG4105ETE Transcriptional regulator (LacI family HPC72_RS02720 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HPC72_RS02740 ENOG4105DH8 myo-inositol catabolism HPC72_RS02745 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HPC72_RS02755 ENOG4105C26 Dehydrogenase HPC72_RS02765 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HPC72_RS02770 ENOG4105F0H myo-inositol catabolism protein HPC72_RS02775 ENOG4107QNK )-transporter HPC72_RS02795 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HPC72_RS02805 ENOG4105WH1 Two component transcriptional regulator luxr family HPC72_RS02810 ENOG4105CPC Aldo Keto reductase HPC72_RS02840 ENOG4105WH1 Two component transcriptional regulator luxr family HPC72_RS02855 ENOG4105ESV Glycosyl transferase, family 4 HPC72_RS02865 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) HPC72_RS02870 ENOG4105ZA1 atp synthase HPC72_RS02875 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HPC72_RS02880 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HPC72_RS02885 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HPC72_RS02890 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HPC72_RS02895 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HPC72_RS02925 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) HPC72_RS02940 ENOG4105CE4 GlcNAc 6-P deacetylase HPC72_RS02955 ENOG4106032 Glutathionylspermidine synthase HPC72_RS02965 ENOG4108638 50S ribosomal protein L36 HPC72_RS02970 ENOG4105NRA 50s ribosomal protein l31 type b HPC72_RS02975 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HPC72_RS02980 ENOG4105W0E 50S ribosomal protein L33 HPC72_RS02985 ENOG4105KDC 50s ribosomal protein l28 HPC72_RS02995 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HPC72_RS03010 ENOG4105CGK Exodeoxyribonuclease III HPC72_RS03020 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HPC72_RS03035 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HPC72_RS03045 ENOG4107SIG periplasmic solute binding protein HPC72_RS03050 ENOG4105D5T phosphonate abc transporter HPC72_RS03055 ENOG4105CC5 ABC transporter HPC72_RS03065 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain HPC72_RS03070 ENOG4108URH decarboxylase HPC72_RS03085 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HPC72_RS03100 ENOG4105CJW magnesium transporter HPC72_RS03115 ENOG4105PGM cation diffusion facilitator family transporter HPC72_RS03140 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HPC72_RS03145 ENOG4105C1J atp-dependent rna helicase HPC72_RS03215 ENOG4105C5Q Transcriptional regulator HPC72_RS03220 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HPC72_RS03240 ENOG4105BZ1 (ABC) transporter HPC72_RS03250 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HPC72_RS03265 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HPC72_RS03295 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HPC72_RS03300 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) HPC72_RS03310 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HPC72_RS03315 ENOG4105C31 Tryptophanyl-tRNA synthetase HPC72_RS03330 ENOG4105BZJ Electron transfer flavoprotein HPC72_RS03335 ENOG4105C10 Electron transfer flavoprotein HPC72_RS03340 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HPC72_RS03365 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HPC72_RS03405 ENOG4105DET Rhamnulokinase HPC72_RS03410 ENOG41063PX domain protein HPC72_RS03425 ENOG4105DJZ UPF0182 protein HPC72_RS03560 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPC72_RS03570 ENOG4107QJE Chromosome Partitioning Protein HPC72_RS03590 ENOG4105C9Q fumarate hydratase class II HPC72_RS03595 ENOG4108IJ8 ABC transporter HPC72_RS03615 ENOG4105ETE Transcriptional regulator (LacI family HPC72_RS03620 ENOG4105CK5 oxidoreductase HPC72_RS03625 ENOG4107TTA Xylose isomerase domain protein TIM barrel HPC72_RS03630 ENOG4107QNK )-transporter HPC72_RS03640 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HPC72_RS03645 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HPC72_RS03680 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HPC72_RS03690 ENOG4108IUX (ABC) transporter HPC72_RS03700 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HPC72_RS03705 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HPC72_RS03710 ENOG4107TXC Transcriptional regulator HPC72_RS03720 ENOG4108S01 response regulator HPC72_RS03725 ENOG4105BZU Histidine kinase HPC72_RS03735 ENOG4108M15 ABC transporter HPC72_RS03740 ENOG4105BZG amino acid carrier protein HPC72_RS03745 ENOG4105K5M 30s ribosomal protein S16 HPC72_RS03750 ENOG41082KU UPF0109 protein HPC72_RS03755 ENOG4105CPC Aldo Keto reductase HPC72_RS03760 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HPC72_RS03765 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HPC72_RS03770 ENOG4107QYR Signal peptidase i HPC72_RS03780 ENOG4107QYR Signal peptidase i HPC72_RS03785 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HPC72_RS03795 ENOG4105VFF UPF0102 protein HPC72_RS03810 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPC72_RS03820 ENOG4105CE9 30S ribosomal protein S2 HPC72_RS03825 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HPC72_RS03840 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HPC72_RS03845 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HPC72_RS03850 ENOG4105KNE Phosphatidate cytidylyltransferase HPC72_RS03855 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HPC72_RS03865 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HPC72_RS03870 ENOG4105DZP Membrane-associated zinc metalloprotease HPC72_RS03880 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HPC72_RS03890 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HPC72_RS03900 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HPC72_RS03915 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HPC72_RS03950 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HPC72_RS03960 ENOG4105E8G Major facilitator Superfamily HPC72_RS03985 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HPC72_RS03990 ENOG4105C1V Peptidase, M16 HPC72_RS03995 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HPC72_RS04005 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPC72_RS04015 ENOG4105CEY Amp-dependent synthetase and ligase HPC72_RS04045 ENOG4108V6E Cell division protein mraZ HPC72_RS04050 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HPC72_RS04060 ENOG4105CJN penicillin-binding protein HPC72_RS04065 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HPC72_RS04075 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HPC72_RS04080 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HPC72_RS04085 ENOG4105CNI cell division protein FtsW HPC72_RS04090 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HPC72_RS04095 ENOG4105DFU Cell wall formation (By similarity) HPC72_RS04105 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HPC72_RS04110 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HPC72_RS04115 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HPC72_RS04125 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) HPC72_RS04145 ENOG4105C0B DNA polymerase III (alpha subunit) HPC72_RS04150 ENOG410848D S4 domain protein YaaA HPC72_RS04170 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HPC72_RS04185 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HPC72_RS04200 ENOG4105C9U ATP-dependent DNA helicase RecQ HPC72_RS04210 ENOG4105EEQ Na H antiporter HPC72_RS04215 ENOG4105CIH Imidazole acetol-phosphate transaminase HPC72_RS04220 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HPC72_RS04235 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HPC72_RS04240 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HPC72_RS04260 ENOG4105DPH UPF0371 protein HPC72_RS04265 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HPC72_RS04280 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HPC72_RS04290 ENOG4108I0Q anthranilate phosphoribosyltransferase HPC72_RS04295 ENOG4105DDQ anthranilate synthase HPC72_RS04300 ENOG4105CRQ synthase (Component I) HPC72_RS04305 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HPC72_RS04315 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HPC72_RS04325 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HPC72_RS04330 ENOG4105DJ2 Major Facilitator Superfamily HPC72_RS04340 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HPC72_RS04355 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HPC72_RS04360 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HPC72_RS04365 ENOG4105DFA alanine racemase domain protein HPC72_RS04370 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HPC72_RS04380 ENOG4105CIG ABC transporter HPC72_RS04400 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HPC72_RS04410 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HPC72_RS04420 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HPC72_RS04425 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HPC72_RS04430 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HPC72_RS04435 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HPC72_RS04440 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HPC72_RS04450 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HPC72_RS04480 ENOG4105EAC phosphoserine phosphatase HPC72_RS04485 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HPC72_RS04490 ENOG4107QPH glycogen) synthase HPC72_RS04505 ENOG4105DKW ABC transporter HPC72_RS04530 ENOG4105C5H ABC transporter HPC72_RS04575 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HPC72_RS04595 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPC72_RS04620 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPC72_RS04630 ENOG4105CD3 dihydroorotase HPC72_RS04675 ENOG4107VEG TrkA-N domain protein HPC72_RS04680 ENOG4105C0X amino acid HPC72_RS04685 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HPC72_RS04690 ENOG4107QM5 aconitate hydratase HPC72_RS04695 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HPC72_RS04700 ENOG4105EMU Dehydrogenase HPC72_RS04705 ENOG4108V1U phospholipid-binding protein HPC72_RS04725 ENOG4108IQI permease HPC72_RS04730 ENOG4105C0B DNA polymerase III (alpha subunit) HPC72_RS04740 ENOG4105DSB aldose 1-epimerase HPC72_RS04760 ENOG4107QN2 dihydrolipoyl dehydrogenase HPC72_RS04770 ENOG4105CPC Aldo Keto reductase HPC72_RS04780 ENOG4105CUC YeeE YedE family protein HPC72_RS04800 ENOG4105C2C drug resistance transporter, Bcr CflA HPC72_RS04810 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HPC72_RS04825 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HPC72_RS04835 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HPC72_RS04855 ENOG4105EPD Oligopeptide transporter, Opt family HPC72_RS04860 ENOG4105DK0 Indole-3-glycerol phosphate synthase HPC72_RS04865 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HPC72_RS04895 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HPC72_RS04905 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HPC72_RS04910 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HPC72_RS04940 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HPC72_RS04955 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPC72_RS04960 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HPC72_RS04965 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HPC72_RS04995 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HPC72_RS05000 ENOG4105C5Y PTS System HPC72_RS05010 ENOG4105CID antiterminator HPC72_RS05015 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HPC72_RS05025 ENOG4105CIE May be required for sporulation (By similarity) HPC72_RS05030 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HPC72_RS05035 ENOG4105BZA Phosphoglycerate kinase HPC72_RS05040 ENOG4105CP7 Triose-phosphate isomerase HPC72_RS05060 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HPC72_RS05065 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HPC72_RS05080 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HPC72_RS05090 ENOG4107QP8 phosphohexose isomerase HPC72_RS05115 ENOG4105DB4 HPC72_RS05125 ENOG41067SE Tetr family transcriptional regulator HPC72_RS05135 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HPC72_RS05170 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HPC72_RS05175 ENOG4108UW8 fha domain-containing protein HPC72_RS05195 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HPC72_RS05200 ENOG4105C5Y PTS System HPC72_RS05205 ENOG4105ETE Transcriptional regulator (LacI family HPC72_RS05230 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HPC72_RS05245 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HPC72_RS05250 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HPC72_RS05270 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase HPC72_RS05275 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HPC72_RS05280 ENOG4107XKF NMT1 THI5 Like Domain Protein HPC72_RS05285 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component HPC72_RS05295 ENOG4108RWI nicotinamidase HPC72_RS05305 ENOG4105CK7 Sodium proline symporter HPC72_RS05315 ENOG4105D8K carboxyl transferase HPC72_RS05320 ENOG4108JIK carboxylase HPC72_RS05330 ENOG4105DA5 (ABC) transporter HPC72_RS05335 ENOG4105DJV ribulose-phosphate 3-epimerase HPC72_RS05345 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HPC72_RS05365 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HPC72_RS05375 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HPC72_RS05385 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HPC72_RS05395 ENOG4105SKN orotidine 5''-phosphate decarboxylase HPC72_RS05400 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HPC72_RS05410 ENOG4105CD3 dihydroorotase HPC72_RS05415 ENOG4105CXT aspartate transcarbamylase HPC72_RS05420 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HPC72_RS05430 ENOG410803B Involved in the transcription termination process (By similarity) HPC72_RS05435 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HPC72_RS05445 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HPC72_RS05450 ENOG4105D49 3-dehydroquinate synthase HPC72_RS05455 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HPC72_RS05460 ENOG4105E2X shikimate dehydrogenase HPC72_RS05470 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HPC72_RS05475 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HPC72_RS05480 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HPC72_RS05485 ENOG4105HF0 Membrane HPC72_RS05495 ENOG4107R13 MMPL domain protein HPC72_RS05500 ENOG4107RTD sua5 ycio yrdc ywlc family protein HPC72_RS05505 ENOG41080HT Transcriptional regulator, arsr family HPC72_RS05515 ENOG4105C9M aspartyl-trna synthetase HPC72_RS05545 ENOG4105CUT histidyl-tRNA synthetase HPC72_RS05565 ENOG4105C99 atpase involved in dna repair HPC72_RS05575 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HPC72_RS05580 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HPC72_RS05585 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HPC72_RS05590 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HPC72_RS05600 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HPC72_RS05605 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HPC72_RS05610 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HPC72_RS05615 ENOG4105CDY transcriptional regulatory protein HPC72_RS05620 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HPC72_RS05635 ENOG4105E2K Glycosyl transferase (Group 1 HPC72_RS05640 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase HPC72_RS05655 ENOG4105C22 threonyL-tRNA synthetase HPC72_RS05665 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HPC72_RS05715 ENOG4105C6N Formate acetyltransferase HPC72_RS05740 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HPC72_RS05760 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HPC72_RS05765 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HPC72_RS05775 ENOG4105C5F glutamine synthetase HPC72_RS05785 ENOG4105E5Q amino acid AbC transporter HPC72_RS05790 ENOG4108JEH abc transporter atp-binding protein HPC72_RS05800 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HPC72_RS05805 ENOG4105C5F glutamine synthetase HPC72_RS05810 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HPC72_RS05835 ENOG4107XFJ UPF0246 protein HPC72_RS05845 ENOG4105EGD dinuclear metal center protein, YbgI family HPC72_RS05885 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HPC72_RS05890 ENOG4108IJ0 Aspartate ammonia-lyase HPC72_RS05900 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HPC72_RS05915 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HPC72_RS05960 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HPC72_RS05965 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HPC72_RS05980 ENOG4105BZW Glycerate kinase HPC72_RS05985 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HPC72_RS05995 ENOG4105CPC Aldo Keto reductase HPC72_RS06000 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HPC72_RS06015 ENOG4108HPI phosphatidate Cytidylyltransferase HPC72_RS06030 ENOG4105CIG ABC transporter HPC72_RS06040 ENOG4105VG1 fes assembly suf system protein HPC72_RS06045 ENOG4107YH3 SUF system FeS assembly protein, NifU family HPC72_RS06055 ENOG4105C3K feS assembly ATPase SufC HPC72_RS06065 ENOG4105DIW FeS assembly protein SUFB HPC72_RS06080 ENOG4105ECY inositol monophosphatase HPC72_RS06110 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HPC72_RS06115 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HPC72_RS06130 ENOG4105D4U had-superfamily hydrolase, subfamily iia HPC72_RS06155 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HPC72_RS06160 ENOG4105YXB Toxic component of a toxin-antitoxin (TA) module. A HPC72_RS06175 ENOG4108VX5 3-methyladenine DNA glycosylase HPC72_RS06180 ENOG4105CH7 arginosuccinase HPC72_RS06190 ENOG4105CDH Citrulline--aspartate ligase HPC72_RS06195 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HPC72_RS06200 ENOG4105C8Y Acetylornithine aminotransferase HPC72_RS06205 ENOG4105CAS nag kinase HPC72_RS06210 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HPC72_RS06215 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HPC72_RS06225 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HPC72_RS06230 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HPC72_RS06240 ENOG4105DRP amino acid AbC transporter HPC72_RS06245 ENOG4105EAD ABC transporter HPC72_RS06250 ENOG4107RP9 extracellular solute-binding protein, family 3 HPC72_RS06255 ENOG4105CDA abc transporter atp-binding protein HPC72_RS06260 ENOG4108RWN rrna methyltransferase HPC72_RS06265 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HPC72_RS06270 ENOG41084BS 50S ribosomal protein L35 HPC72_RS06275 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HPC72_RS06290 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HPC72_RS06300 ENOG4105EPR degv family HPC72_RS06305 ENOG4105D7A ATP-binding protein HPC72_RS06310 ENOG4105C8T Leucyl-tRNA synthetase HPC72_RS06315 ENOG4107ZUX Histidine triad (HIT) protein HPC72_RS06345 ENOG4105C8J )-transporter HPC72_RS06370 ENOG4107TB6 phosphoglycerate mutase HPC72_RS06385 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HPC72_RS06390 ENOG4105E98 transcriptional regulator DeoR family HPC72_RS06395 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HPC72_RS06405 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HPC72_RS06410 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HPC72_RS06415 ENOG4105K46 50S ribosomal protein l27 HPC72_RS06420 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HPC72_RS06430 ENOG4105CRE cytochrome C HPC72_RS06440 ENOG4107QIV Cytochrome c biogenesis protein HPC72_RS06455 ENOG4108W6G cytochrome C HPC72_RS06460 ENOG4105C03 ribonuclease HPC72_RS06465 ENOG4105C4M (Ubiquinol oxidase) subunit I HPC72_RS06470 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPC72_RS06475 ENOG4108JJ9 ABC, transporter HPC72_RS06480 ENOG4108JJ8 (ABC) transporter HPC72_RS06495 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HPC72_RS06500 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HPC72_RS06515 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HPC72_RS06530 ENOG4105DP4 dak2 domain fusion protein ylov HPC72_RS06535 ENOG4105VB9 50S ribosomal protein l28 HPC72_RS06545 ENOG4105CPF Cell wall formation (By similarity) HPC72_RS06560 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HPC72_RS06570 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HPC72_RS06575 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HPC72_RS06580 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HPC72_RS06595 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HPC72_RS06605 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HPC72_RS06620 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HPC72_RS06630 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HPC72_RS06640 ENOG4105CWM branched-chain amino acid transport system II carrier protein HPC72_RS06645 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HPC72_RS06650 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HPC72_RS06675 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPC72_RS06695 ENOG4107SJW iron permease, FTR1 HPC72_RS06705 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HPC72_RS06710 ENOG4105E2R ROK family HPC72_RS06725 ENOG4105DRS transport system, permease HPC72_RS06735 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HPC72_RS06740 ENOG4105KC9 Modulates RecA activity (By similarity) HPC72_RS06745 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HPC72_RS06755 ENOG4105WBV Transcriptional regulator HPC72_RS06760 ENOG4105CEV competence damage-inducible protein HPC72_RS06770 ENOG4107QZI cell division protein FtsK HPC72_RS06780 ENOG4105CN5 Metallo-Beta-Lactamase HPC72_RS06815 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HPC72_RS06825 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HPC72_RS06830 ENOG4105BZG amino acid carrier protein HPC72_RS06855 ENOG4107QK5 Homocysteine s-methyltransferase HPC72_RS06860 ENOG4108IQI permease HPC72_RS06865 ENOG410901E Membrane HPC72_RS06905 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HPC72_RS06910 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HPC72_RS06925 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HPC72_RS06935 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HPC72_RS06955 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HPC72_RS06965 ENOG4105CJ1 ABC, transporter HPC72_RS06970 ENOG4108426 dNA-binding protein HPC72_RS06975 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HPC72_RS06980 ENOG4105DKQ ROK family HPC72_RS06985 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPC72_RS06990 ENOG4108JQ7 (ABC) transporter HPC72_RS07005 ENOG4108J59 Extracellular solute-binding protein, family 5 HPC72_RS07010 ENOG4105FDP GntR family transcriptional regulator HPC72_RS07025 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HPC72_RS07035 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) HPC72_RS07040 ENOG4105CAK Cell division ATP-binding protein ftsE HPC72_RS07050 ENOG4107YH6 single-stranded DNA-binding protein HPC72_RS07070 ENOG4105IDI abc transporter atp-binding protein HPC72_RS07075 ENOG4108UGD Serine Threonine protein kinase HPC72_RS07080 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HPC72_RS07090 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HPC72_RS07100 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HPC72_RS07145 ENOG4105K64 Glycosyl transferase, family 2 HPC72_RS07150 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase HPC72_RS07160 ENOG4108KGH TRANSCRIPTIONal HPC72_RS07170 ENOG4105CM2 brancheD-chain amino acid aminotransferase HPC72_RS07175 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HPC72_RS07180 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HPC72_RS07195 ENOG4105D0C transport protein HPC72_RS07200 ENOG4105DWK Membrane HPC72_RS07205 ENOG4105ETE Transcriptional regulator (LacI family HPC72_RS07210 ENOG4105D7K pfkb domain protein HPC72_RS07215 ENOG4105DRS transport system, permease HPC72_RS07220 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HPC72_RS07250 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HPC72_RS07255 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HPC72_RS07260 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HPC72_RS07270 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HPC72_RS07275 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HPC72_RS07280 ENOG4105C6Y Udp-glucose 6-dehydrogenase HPC72_RS07290 ENOG4107YJ4 chain length determinant protein HPC72_RS07300 ENOG4108UW5 maltose o-acetyltransferase HPC72_RS07310 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HPC72_RS07325 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HPC72_RS07330 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HPC72_RS07335 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HPC72_RS07350 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HPC72_RS07355 ENOG410635A Membrane HPC72_RS07370 ENOG4105II7 pyrroline-5-carboxylate reductase HPC72_RS07375 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HPC72_RS07380 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) HPC72_RS07390 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HPC72_RS07395 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HPC72_RS07400 ENOG4108IQE Amp-dependent synthetase and ligase HPC72_RS07410 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HPC72_RS07415 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HPC72_RS07420 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HPC72_RS07425 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HPC72_RS07455 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HPC72_RS07510 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HPC72_RS07560 ENOG4108RCM Nitroreductase HPC72_RS07580 ENOG41067C8 50S ribosomal protein L32 HPC72_RS07585 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HPC72_RS07595 ENOG4105D7W serine acetyltransferase HPC72_RS07605 ENOG4105BZW Glycerate kinase HPC72_RS07610 ENOG4108YZG isomerase HPC72_RS07615 ENOG4105C9K Endothelin-converting enzyme 1 HPC72_RS07635 ENOG4105FDP GntR family transcriptional regulator HPC72_RS07645 ENOG4105C5Y PTS System HPC72_RS07660 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HPC72_RS07665 ENOG4105C29 acyl-CoA thioesterase HPC72_RS07690 ENOG4105CTQ phosphohexokinase HPC72_RS07705 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HPC72_RS07730 ENOG4105E2R ROK family HPC72_RS07795 ENOG4105E0A ABC, transporter HPC72_RS07810 ENOG4105FDP GntR family transcriptional regulator HPC72_RS07835 ENOG4108M15 ABC transporter HPC72_RS07840 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HPC72_RS07845 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HPC72_RS07850 ENOG4105VFB Binds the 23S rRNA (By similarity) HPC72_RS07870 ENOG4108PJD permease HPC72_RS07880 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HPC72_RS07885 ENOG4105D6E homoserine dehydrogenase HPC72_RS07890 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HPC72_RS07895 ENOG4105C75 arginyL-tRNA synthetase HPC72_RS07915 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HPC72_RS07930 ENOG4105C37 (CBS) domain HPC72_RS07935 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HPC72_RS07955 ENOG4105WMN AntiSigma factor HPC72_RS07960 ENOG4105EMN RNA polymerase sigma factor HPC72_RS07980 ENOG4105E9K Isocitrate dehydrogenase HPC72_RS07985 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HPC72_RS07990 ENOG4108VZM 50s ribosomal protein L10 HPC72_RS07995 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HPC72_RS08000 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HPC72_RS08005 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HPC72_RS08025 ENOG4105XTG Pfam:DUF156 HPC72_RS08045 ENOG4107R4N Cell wall formation (By similarity) HPC72_RS08060 ENOG4105CZN Potassium uptake protein HPC72_RS08070 ENOG4107WI4 Aldose-1-epimerase HPC72_RS08075 ENOG4105VDH Dihydroxyacetone kinase HPC72_RS08085 ENOG4105CMT Dihydroxyacetone kinase HPC72_RS08110 ENOG4105H6Q decarboxylase HPC72_RS08125 ENOG4108IPW abc transporter atp-binding protein HPC72_RS08130 ENOG4105CM4 permease protein HPC72_RS08145 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HPC72_RS08150 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HPC72_RS08170 ENOG4105DKT Transcriptional regulator HPC72_RS08175 ENOG4105EF1 ribulokinase HPC72_RS08185 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HPC72_RS08190 ENOG4105D4U had-superfamily hydrolase, subfamily iia HPC72_RS08200 ENOG4107YVI ribose 5-phosphate isomerase HPC72_RS08210 ENOG4105DKT Transcriptional regulator HPC72_RS08215 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HPC72_RS08220 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HPC72_RS08225 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HPC72_RS08235 ENOG4105C59 p-type ATPase HPC72_RS08240 ENOG4105DAA L-lactate HPC72_RS08245 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HPC72_RS08255 ENOG41080R8 Conserved Protein HPC72_RS08270 ENOG4105DEI Mannitol dehydrogenase HPC72_RS08280 ENOG4105DUX Transporter HPC72_RS08285 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HPC72_RS08300 ENOG4105C26 Dehydrogenase HPC72_RS08315 ENOG4105D82 Glutamate dehydrogenase HPC72_RS08330 ENOG4105CRK lysyL-tRNA synthetase HPC72_RS08345 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HPC72_RS08375 ENOG4105EEI dihydropteroate synthase HPC72_RS08380 ENOG4105EUJ GTP cyclohydrolase i HPC72_RS08385 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HPC72_RS08425 ENOG4108UGV hypoxanthine phosphoribosyltransferase HPC72_RS08440 ENOG4105F0N pyrophosphate phospho-hydrolase HPC72_RS08445 ENOG4107SN7 NLP P60 protein HPC72_RS08450 ENOG4108IQK o-acetylhomoserine HPC72_RS08455 ENOG4105DWV Homoserine O-trans-acetylase HPC72_RS08480 ENOG4108RH7 phosphoglycerate mutase HPC72_RS08500 ENOG4108Z4U Ferredoxin HPC72_RS08510 ENOG4105CI3 gtp-binding protein typa HPC72_RS08520 ENOG4105DEN Luciferase family HPC72_RS08525 ENOG4105VKD bioY protein HPC72_RS08545 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HPC72_RS08550 ENOG4105K5B UPF0225 protein HPC72_RS08555 ENOG4105DFM M18 family aminopeptidase HPC72_RS08620 ENOG4106178 UPF0339 protein HPC72_RS08630 ENOG4105DA5 (ABC) transporter HPC72_RS08645 ENOG4107WD8 ABC transporter, permease HPC72_RS08655 ENOG4105C3G gtp-binding protein HPC72_RS08670 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HPC72_RS08675 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HPC72_RS08680 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HPC72_RS08685 ENOG4105D7K pfkb domain protein HPC72_RS08690 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HPC72_RS08700 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HPC72_RS08705 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HPC72_RS08720 ENOG4108YYH Nadph-dependent fmn reductase HPC72_RS08725 ENOG4108YYH Nadph-dependent fmn reductase HPC72_RS08735 ENOG4105C7B Threonine dehydratase HPC72_RS08740 ENOG4105C01 Dihydroxy-acid dehydratase HPC72_RS08745 ENOG4108V1T peptidylprolyl cis-trans isomerase HPC72_RS08755 ENOG4105CJ1 ABC, transporter HPC72_RS08765 ENOG4105BZU Histidine kinase HPC72_RS08770 ENOG4105WH1 Two component transcriptional regulator luxr family HPC72_RS08775 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HPC72_RS08780 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HPC72_RS08785 ENOG4105FF2 Type I DHQase HPC72_RS08805 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HPC72_RS08835 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HPC72_RS08840 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HPC72_RS08895 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HPC72_RS08915 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HPC72_RS08955 ENOG4107TPY serine threonine protein kinase HPC72_RS08965 ENOG4105C5H ABC transporter HPC72_RS08970 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HPC72_RS08975 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HPC72_RS08995 ENOG4105F8V Hydrolase, tatD family HPC72_RS09000 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HPC72_RS09050 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HPC72_RS09060 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HPC72_RS09110 ENOG4105C7N Xanthine uracil vitamin C permease HPC72_RS09140 ENOG4105CFI type iii restriction protein res subunit HPC72_RS09170 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPC72_RS09175 ENOG4105EB3 Histidine kinase HPC72_RS09190 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HPC72_RS09205 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HPC72_RS09215 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HPC72_RS09220 ENOG4105E2R ROK family HPC72_RS09225 ENOG4105C93 Xylose Isomerase HPC72_RS09245 ENOG4108HWW ABC transporter HPC72_RS09280 ENOG4105C2N RNA methyltransferase TrmH family group 3 HPC72_RS09285 ENOG4105C8N cysteinyl-tRNA synthetase HPC72_RS09290 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HPC72_RS09330 ENOG4105F3R pts system mannose fructose sorbose family iid HPC72_RS09335 ENOG4105ETZ PTS System HPC72_RS09340 ENOG4105DAS pts system HPC72_RS09355 ENOG4105ETE Transcriptional regulator (LacI family HPC72_RS09360 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HPC72_RS09370 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HPC72_RS09405 ENOG4105CRK lysyL-tRNA synthetase HPC72_RS09415 ENOG4105F44 Two component transcriptional regulator, winged helix family HPC72_RS09420 ENOG4106F60 Histidine kinase HPC72_RS09425 ENOG4105KNI merR family transcriptional Regulator HPC72_RS09430 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HPC72_RS09435 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HPC72_RS09440 ENOG4105CFG Acts as a chaperone (By similarity) HPC72_RS09455 ENOG4105C2W permease HPC72_RS09480 ENOG4105CQ7 ATP-dependent helicase HPC72_RS09495 ENOG4108UW5 maltose o-acetyltransferase HPC72_RS09500 ENOG4108Z6B deaminase HPC72_RS09505 ENOG4105C94 Transporter HPC72_RS09510 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HPC72_RS09515 ENOG4105D01 (LipO)protein HPC72_RS09520 ENOG4108UMI ABC transporter, permease HPC72_RS09525 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HPC72_RS09535 ENOG4105KJF protein tyrosine phosphatase HPC72_RS09550 ENOG4108RVA ribokinase HPC72_RS09575 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPC72_RS09580 ENOG4105CNT hydrolase family 2 HPC72_RS09585 ENOG4105ETE Transcriptional regulator (LacI family HPC72_RS09610 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPC72_RS09615 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HPC72_RS09655 ENOG4107QW3 Sucrose phosphorylase HPC72_RS09670 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HPC72_RS09685 ENOG4105DSF transport protein HPC72_RS09690 ENOG4105EV9 Alpha Beta Hydrolase HPC72_RS09695 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HPC72_RS09705 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HPC72_RS09725 ENOG4107WGA YidE YbjL HPC72_RS09750 ENOG4105C85 amino acid HPC72_RS09760 ENOG4105WMR Protein CrcB homolog HPC72_RS09765 ENOG41083TI Protein CrcB homolog HPC72_RS09775 ENOG4105DKQ ROK family HPC72_RS09785 ENOG4105DQ5 transport system permease protein HPC72_RS09790 ENOG4105TVJ transport system, permease HPC72_RS09795 ENOG4105E0A ABC, transporter HPC72_RS09805 ENOG4105CDU Replicative dna helicase HPC72_RS09815 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HPC72_RS09820 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HPC72_RS09825 ENOG4107YH6 single-stranded DNA-binding protein HPC72_RS09830 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) HPC72_RS09835 ENOG4105BZ4 penicillin-binding protein HPC72_RS09855 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HPC72_RS09860 ENOG41060W2 glyoxylate carboligase HPC72_RS09870 ENOG4108IUS Transketolase HPC72_RS09875 ENOG4105CV1 Transketolase (EC 2.2.1.1) HPC72_RS09885 ENOG4105CXT aspartate transcarbamylase HPC72_RS09895 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HPC72_RS09905 ENOG410633P Hydantoin racemase HPC72_RS09925 ENOG4108JQ1 Dehydrogenase HPC72_RS09930 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HPC72_RS09935 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HPC72_RS09955 ENOG4105C3M thioredoxin reductase HPC72_RS09960 ENOG4105K63 Thioredoxin HPC72_RS09970 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPC72_RS09975 ENOG4105CPF Cell wall formation (By similarity) HPC72_RS09990 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HPC72_RS10000 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HPC72_RS10005 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HPC72_RS10015 ENOG41084CH 50S ribosomal protein l34