locus-tag	class	description
HCQ94_RS00010	COG0592	DNA-directed DNA polymerase activity
HCQ94_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HCQ94_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HCQ94_RS00025	COG0187	DNA topoisomerase II activity
HCQ94_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCQ94_RS00085	COG3764	Sortase (surface protein transpeptidase)
HCQ94_RS00100	COG1760	l-serine dehydratase
HCQ94_RS00105	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HCQ94_RS00110	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HCQ94_RS00115	COG1780	Probably involved in ribonucleotide reductase function
HCQ94_RS00120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCQ94_RS00125	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCQ94_RS00135	COG1309	transcriptional regulator
HCQ94_RS00140	COG1511	domain protein
HCQ94_RS00145	COG1643	Atp-dependent helicase
HCQ94_RS00155	COG1716	ATPase activity
HCQ94_RS00170	COG0768	penicillin binding
HCQ94_RS00175	COG0515	serine threonine protein kinase
HCQ94_RS00185	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCQ94_RS00195	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HCQ94_RS00200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HCQ94_RS00205	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HCQ94_RS00210	COG0588	phosphoglycerate mutase activity
HCQ94_RS00215	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HCQ94_RS00225	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HCQ94_RS00235	COG0215	cysteine-tRNA ligase activity
HCQ94_RS00240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCQ94_RS00245	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCQ94_RS00305	COG0306	phosphate transporter
HCQ94_RS00310	COG1392	Phosphate transport regulator
HCQ94_RS00320	COG4044	May play a role in the intracellular transport of hydrophobic ligands
HCQ94_RS00330	COG1490	D-aminoacyl-tRNA deacylase activity
HCQ94_RS00340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCQ94_RS00340	COG0574	Belongs to the PEP-utilizing enzyme family
HCQ94_RS00345	COG1301	dicarboxylic acid transport
HCQ94_RS00355	COG2233	PERMEase
HCQ94_RS00360	COG0628	permease
HCQ94_RS00390	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HCQ94_RS00400	COG0717	Belongs to the dCTP deaminase family
HCQ94_RS00425	COG3842	ATPase activity
HCQ94_RS00430	COG0247	lactate metabolic process
HCQ94_RS00430	COG2181	nitrate reductase activity
HCQ94_RS00435	COG1222	aaa ATPase
HCQ94_RS00450	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HCQ94_RS00455	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HCQ94_RS00490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCQ94_RS00500	COG1175	transmembrane transport
HCQ94_RS00505	COG0395	ABC-type sugar transport system, permease component
HCQ94_RS00510	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HCQ94_RS00520	COG0191	fructose-bisphosphate aldolase activity
HCQ94_RS00535	COG0085	RNA polymerase activity
HCQ94_RS00540	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HCQ94_RS00555	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HCQ94_RS00560	COG0049	tRNA binding
HCQ94_RS00565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HCQ94_RS00570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HCQ94_RS00575	COG1216	Glycosyl transferase, family 2
HCQ94_RS00580	COG0051	transcription antitermination factor activity, RNA binding
HCQ94_RS00585	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HCQ94_RS00590	COG0088	Forms part of the polypeptide exit tunnel
HCQ94_RS00595	COG0089	rRNA binding
HCQ94_RS00600	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HCQ94_RS00605	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HCQ94_RS00610	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HCQ94_RS00615	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HCQ94_RS00620	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HCQ94_RS00625	COG0255	Belongs to the universal ribosomal protein uL29 family
HCQ94_RS00635	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HCQ94_RS00640	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HCQ94_RS00645	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HCQ94_RS00650	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HCQ94_RS00655	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HCQ94_RS00660	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HCQ94_RS00670	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HCQ94_RS00675	COG1841	ribosomal large subunit assembly
HCQ94_RS00680	COG0200	Binds to the 23S rRNA
HCQ94_RS00685	COG0201	protein transport
HCQ94_RS00690	COG0563	adenylate kinase activity
HCQ94_RS00695	COG0024	Methionine aminopeptidase
HCQ94_RS00700	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HCQ94_RS00705	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HCQ94_RS00710	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HCQ94_RS00715	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HCQ94_RS00720	COG0202	RNA polymerase activity
HCQ94_RS00725	COG0203	ribosomal protein L17
HCQ94_RS00730	COG0101	tRNA pseudouridine synthase activity
HCQ94_RS00735	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HCQ94_RS00740	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HCQ94_RS00760	COG1072	(Pantothenic acid kinase))
HCQ94_RS00765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HCQ94_RS00810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCQ94_RS00815	COG0084	hydrolase, TatD family'
HCQ94_RS00820	COG4932	domain protein
HCQ94_RS00820	COG3583	domain protein
HCQ94_RS00820	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HCQ94_RS00830	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HCQ94_RS00840	COG1288	antiporter activity
HCQ94_RS00845	COG0488	(ABC) transporter
HCQ94_RS00860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HCQ94_RS00875	COG0193	aminoacyl-tRNA hydrolase activity
HCQ94_RS00885	COG0148	phosphopyruvate hydratase activity
HCQ94_RS00910	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HCQ94_RS00920	COG2197	response regulator
HCQ94_RS00935	COG0545	Peptidyl-prolyl cis-trans isomerase
HCQ94_RS00940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HCQ94_RS00945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HCQ94_RS00955	COG1722	exodeoxyribonuclease VII activity
HCQ94_RS00965	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HCQ94_RS00970	COG0012	GTP binding
HCQ94_RS00985	COG0601	transmembrane transport
HCQ94_RS00990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCQ94_RS00995	COG4172	Belongs to the ABC transporter superfamily
HCQ94_RS01000	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HCQ94_RS01005	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HCQ94_RS01040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HCQ94_RS01045	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HCQ94_RS01050	COG1216	Glycosyl transferase, family 2
HCQ94_RS01055	COG1216	Glycosyl transferase, family 2
HCQ94_RS01060	COG1215	transferase activity, transferring glycosyl groups
HCQ94_RS01075	COG2239	Acts as a magnesium transporter
HCQ94_RS01090	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HCQ94_RS01090	COG2755	lipolytic protein G-D-S-L family
HCQ94_RS01095	COG1278	Cold shock
HCQ94_RS01110	COG2252	PERMEase
HCQ94_RS01125	COG1321	iron dependent repressor
HCQ94_RS01130	COG0791	NLP P60 protein
HCQ94_RS01155	COG1959	2 iron, 2 sulfur cluster binding
HCQ94_RS01165	COG0321	lipoyl(octanoyl) transferase activity
HCQ94_RS01170	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HCQ94_RS01175	COG0318	PFAM AMP-dependent synthetase and ligase
HCQ94_RS01190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HCQ94_RS01195	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HCQ94_RS01205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCQ94_RS01215	COG1611	Belongs to the LOG family
HCQ94_RS01265	COG0443	Heat shock 70 kDa protein
HCQ94_RS01275	COG0484	heat shock protein binding
HCQ94_RS01280	COG0789	Transcriptional regulator
HCQ94_RS01285	COG0569	domain protein
HCQ94_RS01285	COG2985	domain, Protein
HCQ94_RS01300	COG4221	oxidoreductase activity
HCQ94_RS01310	COG0802	atpase or kinase
HCQ94_RS01315	COG1214	PFAM Peptidase M22, glycoprotease
HCQ94_RS01315	COG0456	acetyltransferase
HCQ94_RS01330	COG1053	succinate dehydrogenase
HCQ94_RS01335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HCQ94_RS01340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HCQ94_RS01350	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HCQ94_RS01395	COG1555	photosystem II stabilization
HCQ94_RS01415	COG1162	GTPase activity
HCQ94_RS01425	COG1595	DNA-templated transcription, initiation
HCQ94_RS01450	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCQ94_RS01450	COG0567	Dehydrogenase, E1 component
HCQ94_RS01465	COG0739	heme binding
HCQ94_RS01465	COG0741	lytic transglycosylase activity
HCQ94_RS01465	COG1196	nuclear chromosome segregation
HCQ94_RS01470	COG0584	glycerophosphoryl diester phosphodiesterase
HCQ94_RS01480	COG1953	Uracil, thiamine, allantoin
HCQ94_RS01495	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HCQ94_RS01505	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HCQ94_RS01510	COG0318	PFAM AMP-dependent synthetase and ligase
HCQ94_RS01515	COG3973	AAA domain
HCQ94_RS01515	COG3973	AAA domain
HCQ94_RS01525	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCQ94_RS01535	COG2001	Belongs to the MraZ family
HCQ94_RS01540	COG0275	rRNA processing
HCQ94_RS01550	COG0768	penicillin binding
HCQ94_RS01560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HCQ94_RS01565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCQ94_RS01570	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HCQ94_RS01575	COG0772	Belongs to the SEDS family
HCQ94_RS01585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HCQ94_RS01600	COG1496	oxidoreductase activity
HCQ94_RS01605	COG1799	cell septum assembly
HCQ94_RS01620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HCQ94_RS01645	COG0583	DNA-binding transcription factor activity
HCQ94_RS01655	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HCQ94_RS01660	COG1288	antiporter activity
HCQ94_RS01665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HCQ94_RS01675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HCQ94_RS01680	COG0742	ribosomal rna small subunit methyltransferase
HCQ94_RS01685	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HCQ94_RS01710	COG1132	(ABC) transporter
HCQ94_RS01715	COG4988	ABC transporter
HCQ94_RS01720	COG1294	oxidase, subunit
HCQ94_RS01725	COG1271	oxidase subunit
HCQ94_RS01730	COG1530	ribonuclease E activity
HCQ94_RS01735	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HCQ94_RS01740	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HCQ94_RS01745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HCQ94_RS01750	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HCQ94_RS01755	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HCQ94_RS01760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HCQ94_RS01765	COG0799	negative regulation of ribosome biogenesis
HCQ94_RS01770	COG0588	phosphoglycerate mutase activity
HCQ94_RS01815	COG1442	glycosyl transferase family 8
HCQ94_RS01830	COG1321	iron dependent repressor
HCQ94_RS01830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCQ94_RS01835	COG1121	(ABC) transporter
HCQ94_RS01840	COG0803	Belongs to the bacterial solute-binding protein 9 family
HCQ94_RS01845	COG0813	purine-nucleoside phosphorylase activity
HCQ94_RS01850	COG0733	neurotransmitter:sodium symporter activity
HCQ94_RS01870	COG0268	Binds directly to 16S ribosomal RNA
HCQ94_RS01875	COG0481	GTPase activity
HCQ94_RS01880	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HCQ94_RS01885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCQ94_RS01890	COG1420	regulation of RNA biosynthetic process
HCQ94_RS01895	COG0484	heat shock protein binding
HCQ94_RS01900	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HCQ94_RS01905	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HCQ94_RS01915	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HCQ94_RS01920	COG0778	Nitroreductase
HCQ94_RS01925	COG1381	Involved in DNA repair and RecF pathway recombination
HCQ94_RS01935	COG0018	arginyl-trna synthetase
HCQ94_RS01940	COG0460	homoserine dehydrogenase
HCQ94_RS01950	COG0254	rRNA binding
HCQ94_RS01955	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HCQ94_RS01965	COG0009	L-threonylcarbamoyladenylate synthase
HCQ94_RS01980	COG0356	it plays a direct role in the translocation of protons across the membrane
HCQ94_RS01985	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCQ94_RS01990	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HCQ94_RS01995	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCQ94_RS02000	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HCQ94_RS02005	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HCQ94_RS02010	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HCQ94_RS02025	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HCQ94_RS02035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCQ94_RS02065	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HCQ94_RS02075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HCQ94_RS02080	COG3022	response to hydroperoxide
HCQ94_RS02085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HCQ94_RS02090	COG0494	nUDIX hydrolase
HCQ94_RS02110	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HCQ94_RS02130	COG0512	Glutamine amidotransferase of anthranilate synthase
HCQ94_RS02150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HCQ94_RS02155	COG0735	belongs to the Fur family
HCQ94_RS02160	COG0423	glycine-tRNA ligase activity
HCQ94_RS02180	COG1615	UPF0182 protein
HCQ94_RS02220	COG1088	dTDP-glucose 4,6-dehydratase activity
HCQ94_RS02235	COG0629	single-stranded DNA binding
HCQ94_RS02245	COG3590	peptidase
HCQ94_RS02260	COG1045	serine acetyltransferase
HCQ94_RS02265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCQ94_RS02270	COG1739	Uncharacterized protein family UPF0029
HCQ94_RS02275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCQ94_RS02280	COG1397	ADP-ribosylglycohydrolase
HCQ94_RS02295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCQ94_RS02320	COG0539	negative regulation of cytoplasmic translation
HCQ94_RS02335	COG0052	Belongs to the universal ribosomal protein uS2 family
HCQ94_RS02340	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HCQ94_RS02355	COG0114	fumarate hydratase activity
HCQ94_RS02365	COG0343	queuine tRNA-ribosyltransferase activity
HCQ94_RS02370	COG0833	amino acid
HCQ94_RS02380	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HCQ94_RS02385	COG1518	maintenance of DNA repeat elements
HCQ94_RS02390	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HCQ94_RS02430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCQ94_RS02435	COG1126	abc transporter atp-binding protein
HCQ94_RS02440	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HCQ94_RS02460	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCQ94_RS02470	COG0719	Fe-S assembly protein
HCQ94_RS02485	COG0396	ATPase activity
HCQ94_RS02495	COG0822	iron-sulfur transferase activity
HCQ94_RS02500	COG0174	glutamine synthetase
HCQ94_RS02510	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HCQ94_RS02515	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HCQ94_RS02520	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HCQ94_RS02530	COG0528	UMP kinase activity
HCQ94_RS02535	COG0233	cytoplasmic translational termination
HCQ94_RS02540	COG0575	Belongs to the CDS family
HCQ94_RS02545	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HCQ94_RS02555	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HCQ94_RS02560	COG0750	zinc metalloprotease
HCQ94_RS02565	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HCQ94_RS02575	COG0442	prolyl-tRNA aminoacylation
HCQ94_RS02590	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HCQ94_RS02610	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HCQ94_RS02630	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HCQ94_RS02635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCQ94_RS02640	COG0194	GDP metabolic process
HCQ94_RS02645	COG1758	RNA polymerase activity
HCQ94_RS02660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HCQ94_RS02670	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCQ94_RS02675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCQ94_RS02680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCQ94_RS02695	COG0322	excinuclease ABC activity
HCQ94_RS02705	COG0714	Associated with various cellular activities
HCQ94_RS02735	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HCQ94_RS02740	COG0653	protein targeting
HCQ94_RS02765	COG1940	carbohydrate kinase activity
HCQ94_RS02780	COG2815	serine threonine protein kinase
HCQ94_RS02780	COG0515	serine threonine protein kinase
HCQ94_RS02785	COG0142	geranyltranstransferase activity
HCQ94_RS02795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCQ94_RS02800	COG0187	DNA topoisomerase II activity
HCQ94_RS02805	COG1216	Glycosyl transferase, family 2
HCQ94_RS02805	COG1442	glycosyl transferase family 8
HCQ94_RS02815	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCQ94_RS02855	COG0569	domain protein
HCQ94_RS02860	COG0531	amino acid
HCQ94_RS02865	COG2226	methyltransferase
HCQ94_RS02880	COG2267	carboxylic ester hydrolase activity
HCQ94_RS02885	COG0494	nUDIX hydrolase
HCQ94_RS02905	COG0583	DNA-binding transcription factor activity
HCQ94_RS02930	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HCQ94_RS02955	COG1132	(ABC) transporter
HCQ94_RS02965	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HCQ94_RS02970	COG2364	Membrane
HCQ94_RS02980	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HCQ94_RS02985	COG0792	nuclease activity
HCQ94_RS02990	COG0606	chelatase, subunit chli
HCQ94_RS03020	COG1187	pseudouridine synthase activity
HCQ94_RS03025	COG1160	GTP binding
HCQ94_RS03030	COG4988	ABC transporter
HCQ94_RS03035	COG1132	(ABC) transporter
HCQ94_RS03040	COG3311	Transcriptional regulator
HCQ94_RS03055	COG0596	Alpha beta hydrolase
HCQ94_RS03070	COG1716	ATPase activity
HCQ94_RS03080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCQ94_RS03085	COG0805	protein transport
HCQ94_RS03090	COG0672	)-iron permease
HCQ94_RS03095	COG2837	iron assimilation
HCQ94_RS03100	COG2822	iron ion transport
HCQ94_RS03120	COG3189	MarR family transcriptional regulator
HCQ94_RS03140	COG1125	glycine betaine transport
HCQ94_RS03140	COG0517	IMP dehydrogenase activity
HCQ94_RS03165	COG0702	epimerase
HCQ94_RS03170	COG2197	response regulator
HCQ94_RS03175	COG4585	Histidine kinase
HCQ94_RS03180	COG0842	Transport permease protein
HCQ94_RS03185	COG1131	(ABC) transporter
HCQ94_RS03190	COG3620	sequence-specific DNA binding
HCQ94_RS03215	COG1136	(ABC) transporter
HCQ94_RS03225	COG5002	protein histidine kinase activity
HCQ94_RS03230	COG0745	RESPONSE REGULATOR receiver
HCQ94_RS03270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCQ94_RS03275	COG0789	Transcriptional regulator
HCQ94_RS03310	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HCQ94_RS03325	COG1131	(ABC) transporter
HCQ94_RS03340	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HCQ94_RS03350	COG1695	Transcriptional regulator
HCQ94_RS03365	COG1956	GAF domain-containing protein
HCQ94_RS03375	COG0367	asparagine synthase
HCQ94_RS03410	COG0477	Major facilitator Superfamily
HCQ94_RS03415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HCQ94_RS03420	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HCQ94_RS03425	COG0358	DNA primase activity
HCQ94_RS03430	COG1196	nuclear chromosome segregation
HCQ94_RS03435	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HCQ94_RS03440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCQ94_RS03445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCQ94_RS03450	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCQ94_RS03460	COG2255	four-way junction helicase activity
HCQ94_RS03470	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HCQ94_RS03475	COG0217	transcriptional regulatory protein
HCQ94_RS03485	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HCQ94_RS03490	COG0556	nucleotide-excision repair
HCQ94_RS03495	COG0237	dephospho-CoA kinase activity
HCQ94_RS03530	COG4581	dead DEAH box helicase
HCQ94_RS03550	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HCQ94_RS03555	COG1438	arginine binding
HCQ94_RS03570	COG0745	RESPONSE REGULATOR receiver
HCQ94_RS03575	COG5002	protein histidine kinase activity
HCQ94_RS03585	COG0105	UTP biosynthetic process
HCQ94_RS03595	COG0285	dihydrofolate synthase activity
HCQ94_RS03630	COG1968	undecaprenyl-diphosphatase activity
HCQ94_RS03640	COG0488	(ABC) transporter
HCQ94_RS03645	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HCQ94_RS03650	COG0167	dihydroorotate dehydrogenase activity
HCQ94_RS03655	COG0543	2 iron, 2 sulfur cluster binding
HCQ94_RS03660	COG0284	orotidine-5'-phosphate decarboxylase activity
HCQ94_RS03675	COG0540	Belongs to the ATCase OTCase family
HCQ94_RS03690	COG0740	serine-type endopeptidase activity
HCQ94_RS03700	COG0544	peptidyl-prolyl cis-trans isomerase activity
HCQ94_RS03760	COG4974	Belongs to the 'phage' integrase family
HCQ94_RS03765	COG0166	Belongs to the GPI family
HCQ94_RS03775	COG0765	amino acid transport
HCQ94_RS03780	COG1126	abc transporter atp-binding protein
HCQ94_RS03785	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HCQ94_RS03815	COG0504	CTP synthase activity
HCQ94_RS03845	COG0497	DNA recombination
HCQ94_RS03850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HCQ94_RS03860	COG0647	UMP catabolic process
HCQ94_RS03890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HCQ94_RS03905	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HCQ94_RS03915	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCQ94_RS03920	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCQ94_RS03925	COG0151	Belongs to the GarS family
HCQ94_RS03930	COG0138	bifunctional purine biosynthesis protein purh
HCQ94_RS03935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HCQ94_RS03940	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HCQ94_RS03945	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HCQ94_RS03955	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HCQ94_RS03960	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HCQ94_RS03965	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HCQ94_RS03970	COG0149	triose-phosphate isomerase activity
HCQ94_RS03980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCQ94_RS03985	COG1481	regulation of sporulation
HCQ94_RS04005	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HCQ94_RS04010	COG0681	Belongs to the peptidase S26 family
HCQ94_RS04015	COG0335	large ribosomal subunit rRNA binding
HCQ94_RS04025	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HCQ94_RS04030	COG1837	Belongs to the UPF0109 family
HCQ94_RS04035	COG0228	four-way junction DNA binding
HCQ94_RS04065	COG0667	Aldo Keto reductase
HCQ94_RS04090	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HCQ94_RS04100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HCQ94_RS04105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCQ94_RS04110	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCQ94_RS04135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCQ94_RS04140	COG0154	amidase activity
HCQ94_RS04145	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HCQ94_RS04150	COG1027	Aspartate ammonia-lyase
HCQ94_RS04210	COG1131	(ABC) transporter
HCQ94_RS04220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCQ94_RS04225	COG1121	(ABC) transporter
HCQ94_RS04235	COG0803	Belongs to the bacterial solute-binding protein 9 family
HCQ94_RS04250	COG0424	maF-like protein
HCQ94_RS04270	COG2720	vancomycin resistance protein
HCQ94_RS04275	COG1217	gtp-binding protein TYPA
HCQ94_RS04280	COG1881	PFAM PEBP family protein
HCQ94_RS04285	COG0395	ABC-type sugar transport system, permease component
HCQ94_RS04290	COG1175	transmembrane transport
HCQ94_RS04295	COG1653	transport
HCQ94_RS04300	COG0039	L-malate dehydrogenase activity
HCQ94_RS04370	COG0537	adenosine 5'-monophosphoramidase activity
HCQ94_RS04390	COG2017	converts alpha-aldose to the beta-anomer
HCQ94_RS04400	COG0482	sulfurtransferase activity
HCQ94_RS04410	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HCQ94_RS04420	COG0697	spore germination
HCQ94_RS04450	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HCQ94_RS04455	COG0318	PFAM AMP-dependent synthetase and ligase
HCQ94_RS04475	COG0045	succinate-CoA ligase (ADP-forming) activity
HCQ94_RS04505	COG0133	tryptophan synthase activity
HCQ94_RS04515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HCQ94_RS04520	COG3583	domain protein
HCQ94_RS04545	COG1012	belongs to the aldehyde dehydrogenase family
HCQ94_RS04575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HCQ94_RS04575	COG0519	Catalyzes the synthesis of GMP from XMP
HCQ94_RS04590	COG0280	phosphate acetyltransferase
HCQ94_RS04590	COG0857	belongs to the CobB CobQ family
HCQ94_RS04610	COG1316	TRANSCRIPTIONal
HCQ94_RS04615	COG1316	TRANSCRIPTIONal
HCQ94_RS04620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCQ94_RS04625	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HCQ94_RS04630	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HCQ94_RS04655	COG2205	protein histidine kinase activity
HCQ94_RS04660	COG0745	RESPONSE REGULATOR receiver
HCQ94_RS04685	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCQ94_RS04705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HCQ94_RS04725	COG0438	transferase activity, transferring glycosyl groups
HCQ94_RS04730	COG0251	oxidation-reduction process
HCQ94_RS04760	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HCQ94_RS04770	COG1115	amino acid carrier protein
HCQ94_RS04775	COG1115	amino acid carrier protein
HCQ94_RS04780	COG1115	amino acid carrier protein
HCQ94_RS04785	COG0129	dihydroxy-acid dehydratase activity
HCQ94_RS04790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCQ94_RS04795	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HCQ94_RS04800	COG0440	acetolactate synthase activity
HCQ94_RS04825	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HCQ94_RS04830	COG0154	amidase activity
HCQ94_RS04835	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HCQ94_RS04845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HCQ94_RS04850	COG1674	ftsk spoiiie
HCQ94_RS04880	COG2813	Specifically methylates the guanine in position
HCQ94_RS04885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HCQ94_RS04900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCQ94_RS04905	COG1058	Belongs to the CinA family
HCQ94_RS04905	COG1546	Belongs to the CinA family
HCQ94_RS04910	COG2137	regulation of response to DNA damage stimulus
HCQ94_RS04915	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HCQ94_RS04930	COG1396	sequence-specific DNA binding
HCQ94_RS04940	COG1674	ftsk spoiiie
HCQ94_RS04950	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HCQ94_RS04955	COG0612	Peptidase, M16
HCQ94_RS04960	COG1185	polyribonucleotide nucleotidyltransferase activity
HCQ94_RS04965	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HCQ94_RS04990	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HCQ94_RS04995	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HCQ94_RS04995	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HCQ94_RS05025	COG1404	Belongs to the peptidase S8 family
HCQ94_RS05030	COG0741	lytic transglycosylase activity
HCQ94_RS05055	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HCQ94_RS05065	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HCQ94_RS05075	COG4720	Psort location CytoplasmicMembrane, score
HCQ94_RS05085	COG0730	response to heat
HCQ94_RS05115	COG2177	Part of the ABC transporter FtsEX involved in
HCQ94_RS05120	COG2884	Cell division ATP-binding protein ftsE
HCQ94_RS05125	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HCQ94_RS05165	COG2095	MarC family integral membrane protein
HCQ94_RS05170	COG0587	DNA-directed DNA polymerase activity
HCQ94_RS05175	COG0006	proline dipeptidase activity
HCQ94_RS05180	COG2706	6-phosphogluconolactonase activity
HCQ94_RS05185	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HCQ94_RS05190	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HCQ94_RS05205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCQ94_RS05215	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HCQ94_RS05235	COG0459	protein refolding
HCQ94_RS05250	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HCQ94_RS05255	COG0733	neurotransmitter:sodium symporter activity
HCQ94_RS05265	COG0596	Alpha beta hydrolase
HCQ94_RS05275	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HCQ94_RS05275	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HCQ94_RS05295	COG3842	ATPase activity
HCQ94_RS05320	COG1260	myo-inositol-1-phosphate synthase
HCQ94_RS05330	COG1119	ATPase activity
HCQ94_RS05335	COG0222	ribosome binding
HCQ94_RS05340	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HCQ94_RS05355	COG0081	regulation of translation
HCQ94_RS05360	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HCQ94_RS05365	COG0250	Participates in transcription elongation, termination and antitermination
HCQ94_RS05380	COG0436	Aminotransferase
HCQ94_RS05390	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HCQ94_RS05400	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HCQ94_RS05425	COG1666	GTP binding
HCQ94_RS05430	COG0501	Belongs to the peptidase M48B family
HCQ94_RS05440	COG0493	'glutamate synthase
HCQ94_RS05445	COG0142	geranyltranstransferase activity
HCQ94_RS05460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HCQ94_RS05465	COG0713	ATP synthesis coupled electron transport
HCQ94_RS05470	COG0839	Belongs to the complex I subunit 6 family
HCQ94_RS05475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCQ94_RS05480	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HCQ94_RS05485	COG1034	ATP synthesis coupled electron transport
HCQ94_RS05490	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HCQ94_RS05500	COG0649	NAD binding
HCQ94_RS05505	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCQ94_RS05510	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCQ94_RS05520	COG2226	methyltransferase
HCQ94_RS05525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCQ94_RS05530	COG0477	Major facilitator Superfamily
HCQ94_RS05535	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HCQ94_RS05560	COG0549	Belongs to the carbamate kinase family
HCQ94_RS05565	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HCQ94_RS05600	COG0569	domain protein
HCQ94_RS05610	COG0406	alpha-ribazole phosphatase activity
HCQ94_RS05615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HCQ94_RS05620	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HCQ94_RS05630	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HCQ94_RS05645	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HCQ94_RS05650	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HCQ94_RS05655	COG0302	gtp cyclohydrolase
HCQ94_RS05660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCQ94_RS05670	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HCQ94_RS05680	COG0037	tRNA processing
HCQ94_RS05685	COG3883	PFAM NLP P60 protein
HCQ94_RS05685	COG0791	NLP P60 protein
HCQ94_RS05705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HCQ94_RS05710	COG0590	tRNA wobble adenosine to inosine editing
HCQ94_RS05720	COG2011	ABC-type metal ion transport system permease component
HCQ94_RS05725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCQ94_RS05730	COG0577	efflux transmembrane transporter activity
HCQ94_RS05735	COG1136	(ABC) transporter
HCQ94_RS05740	COG0642	Histidine kinase
HCQ94_RS05745	COG0745	RESPONSE REGULATOR receiver
HCQ94_RS05775	COG3442	glutamine amidotransferase
HCQ94_RS05780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HCQ94_RS05790	COG0561	phosphatase activity
HCQ94_RS05795	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HCQ94_RS05805	COG1597	lipid kinase activity
HCQ94_RS05805	COG1803	Methylglyoxal synthase
HCQ94_RS05810	COG1215	transferase activity, transferring glycosyl groups
HCQ94_RS05845	COG2860	membrane
HCQ94_RS05855	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HCQ94_RS05860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCQ94_RS05875	COG0124	histidyl-tRNA synthetase
HCQ94_RS05880	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HCQ94_RS05885	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HCQ94_RS05890	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCQ94_RS05890	COG1754	DNA topoisomerase type I activity
HCQ94_RS05895	COG2890	protein-(glutamine-N5) methyltransferase activity
HCQ94_RS05955	COG1064	alcohol dehydrogenase
HCQ94_RS05965	COG1408	metallophosphoesterase
HCQ94_RS05970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCQ94_RS05980	COG0251	oxidation-reduction process
HCQ94_RS06015	COG2217	Heavy metal translocating P-type atpase
HCQ94_RS06020	COG0586	Pfam SNARE associated Golgi protein
HCQ94_RS06035	COG0359	binds to the 23S rRNA
HCQ94_RS06040	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HCQ94_RS06050	COG0360	Binds together with S18 to 16S ribosomal RNA
HCQ94_RS06055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCQ94_RS06080	COG2807	transmembrane transport
HCQ94_RS06090	COG0038	chloride channel
HCQ94_RS06095	COG0305	Participates in initiation and elongation during chromosome replication
HCQ94_RS06110	COG0488	(ABC) transporter
HCQ94_RS06125	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HCQ94_RS06130	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HCQ94_RS06140	COG0492	ferredoxin-NADP+ reductase activity
HCQ94_RS06145	COG3118	belongs to the thioredoxin family
HCQ94_RS06150	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCQ94_RS06155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCQ94_RS06160	COG1475	DNA binding
HCQ94_RS06165	COG1192	Involved in chromosome partitioning
HCQ94_RS06175	COG1393	Belongs to the ArsC family
HCQ94_RS06185	COG0357	Ribosomal RNA small subunit methyltransferase G
HCQ94_RS06195	COG0706	membrane insertase activity
HCQ94_RS06205	COG0594	ribonuclease P activity
HCQ94_RS06210	COG0230	Belongs to the bacterial ribosomal protein bL34 family