locus-tag	class	description
I2V18_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I2V18_RS00010	COG0592	DNA-directed DNA polymerase activity
I2V18_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I2V18_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I2V18_RS00025	COG0187	DNA topoisomerase II activity
I2V18_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I2V18_RS00055	COG0656	L-ascorbic acid biosynthetic process
I2V18_RS00080	COG3764	Sortase (surface protein transpeptidase)
I2V18_RS00090	COG0515	serine threonine protein kinase
I2V18_RS00095	COG0515	serine threonine protein kinase
I2V18_RS00100	COG0768	penicillin binding
I2V18_RS00115	COG1716	ATPase activity
I2V18_RS00130	COG1716	ATPase activity
I2V18_RS00140	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I2V18_RS00145	COG2985	domain, Protein
I2V18_RS00145	COG0569	domain protein
I2V18_RS00165	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I2V18_RS00170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I2V18_RS00180	COG0789	Transcriptional regulator
I2V18_RS00190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2V18_RS00195	COG0360	Binds together with S18 to 16S ribosomal RNA
I2V18_RS00200	COG0629	single-stranded DNA binding
I2V18_RS00205	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I2V18_RS00210	COG0359	binds to the 23S rRNA
I2V18_RS00220	COG0305	Participates in initiation and elongation during chromosome replication
I2V18_RS00240	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I2V18_RS00275	COG0471	metal ion transport
I2V18_RS00280	COG2205	protein histidine kinase activity
I2V18_RS00290	COG0628	permease
I2V18_RS00300	COG0351	phosphomethylpyrimidine kinase
I2V18_RS00340	COG3550	peptidyl-serine autophosphorylation
I2V18_RS00355	COG0366	Alpha amylase catalytic
I2V18_RS00370	COG2409	Drug exporters of the RND superfamily
I2V18_RS00390	COG1780	Probably involved in ribonucleotide reductase function
I2V18_RS00395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I2V18_RS00410	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I2V18_RS00450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I2V18_RS00475	COG2011	ABC-type metal ion transport system permease component
I2V18_RS00480	COG1464	Belongs to the NlpA lipoprotein family
I2V18_RS00550	COG2197	response regulator
I2V18_RS00555	COG4585	Histidine kinase
I2V18_RS00560	COG1131	(ABC) transporter
I2V18_RS00570	COG2181	nitrate reductase activity
I2V18_RS00570	COG0247	lactate metabolic process
I2V18_RS00585	COG4149	molybdate abc transporter
I2V18_RS00590	COG3842	ATPase activity
I2V18_RS00635	COG3842	ATPase activity
I2V18_RS00645	COG1840	ABC-type Fe3 transport system, periplasmic component
I2V18_RS00650	COG0745	RESPONSE REGULATOR receiver
I2V18_RS00655	COG3852	Histidine kinase
I2V18_RS00665	COG1733	regulation of RNA biosynthetic process
I2V18_RS00710	COG0443	Heat shock 70 kDa protein
I2V18_RS00715	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I2V18_RS00720	COG0484	heat shock protein binding
I2V18_RS00725	COG0789	Transcriptional regulator
I2V18_RS00745	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I2V18_RS00745	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I2V18_RS00760	COG0542	response to heat
I2V18_RS00770	COG0584	glycerophosphoryl diester phosphodiesterase
I2V18_RS00800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I2V18_RS00805	COG3588	fructose-bisphosphate aldolase
I2V18_RS00810	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I2V18_RS00815	COG0215	cysteine-tRNA ligase activity
I2V18_RS00840	COG3842	ATPase activity
I2V18_RS00860	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I2V18_RS00880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I2V18_RS00885	COG1643	Atp-dependent helicase
I2V18_RS00900	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I2V18_RS00905	COG3142	Participates in the control of copper homeostasis
I2V18_RS00910	COG4988	ABC transporter
I2V18_RS00915	COG1132	(ABC) transporter
I2V18_RS00920	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I2V18_RS00925	COG2860	membrane
I2V18_RS00940	COG1674	ftsk spoiiie
I2V18_RS01015	COG5650	phosphatidylinositol metabolic process
I2V18_RS01045	COG0714	Associated with various cellular activities
I2V18_RS01120	COG2176	DNA-directed DNA polymerase activity
I2V18_RS01135	COG0778	Nitroreductase
I2V18_RS01155	COG1175	transmembrane transport
I2V18_RS01160	COG0395	ABC-type sugar transport system, permease component
I2V18_RS01165	COG4221	oxidoreductase activity
I2V18_RS01170	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I2V18_RS01175	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I2V18_RS01180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I2V18_RS01185	COG0191	fructose-bisphosphate aldolase activity
I2V18_RS01215	COG2197	response regulator
I2V18_RS01235	COG0577	efflux transmembrane transporter activity
I2V18_RS01235	COG1136	(ABC) transporter
I2V18_RS01240	COG1136	(ABC) transporter
I2V18_RS01255	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I2V18_RS01270	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I2V18_RS01280	COG0151	Belongs to the GarS family
I2V18_RS01285	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I2V18_RS01305	COG0047	phosphoribosylformylglycinamidine synthase activity
I2V18_RS01310	COG0297	glycogen (starch) synthase activity
I2V18_RS01320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I2V18_RS01345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I2V18_RS01350	COG0737	Belongs to the 5'-nucleotidase family
I2V18_RS01360	COG1349	DNA-binding transcription factor activity
I2V18_RS01365	COG1105	Belongs to the carbohydrate kinase PfkB family
I2V18_RS01370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I2V18_RS01370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I2V18_RS01370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2V18_RS01380	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I2V18_RS01405	COG1472	Belongs to the glycosyl hydrolase 3 family
I2V18_RS01410	COG0577	efflux transmembrane transporter activity
I2V18_RS01415	COG0577	efflux transmembrane transporter activity
I2V18_RS01415	COG1136	(ABC) transporter
I2V18_RS01465	COG0577	efflux transmembrane transporter activity
I2V18_RS01465	COG1136	(ABC) transporter
I2V18_RS01480	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I2V18_RS01495	COG0513	Belongs to the DEAD box helicase family
I2V18_RS01520	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I2V18_RS01525	COG0494	nUDIX hydrolase
I2V18_RS01525	COG0406	alpha-ribazole phosphatase activity
I2V18_RS01530	COG0745	RESPONSE REGULATOR receiver
I2V18_RS01540	COG3485	protocatechuate 3,4-dioxygenase
I2V18_RS01545	COG0354	folic acid binding
I2V18_RS01555	COG1490	D-aminoacyl-tRNA deacylase activity
I2V18_RS01570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I2V18_RS01570	COG0574	Belongs to the PEP-utilizing enzyme family
I2V18_RS01600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I2V18_RS01605	COG2873	o-acetylhomoserine
I2V18_RS01615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I2V18_RS01620	COG2027	D-alanyl-D-alanine carboxypeptidase
I2V18_RS01630	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I2V18_RS01690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I2V18_RS01695	COG0302	gtp cyclohydrolase
I2V18_RS01700	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I2V18_RS01710	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I2V18_RS01735	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I2V18_RS01740	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I2V18_RS01745	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I2V18_RS01755	COG1136	(ABC) transporter
I2V18_RS01785	COG1556	Lactate utilization protein
I2V18_RS01790	COG1139	Iron-sulfur cluster binding protein
I2V18_RS01795	COG0247	lactate metabolic process
I2V18_RS01810	COG1620	l-lactate permease
I2V18_RS01820	COG0446	pyridine nucleotide-disulphide oxidoreductase
I2V18_RS01825	COG1937	Protein conserved in bacteria
I2V18_RS01830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I2V18_RS01835	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I2V18_RS01840	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I2V18_RS01850	COG0247	lactate metabolic process
I2V18_RS01865	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I2V18_RS01895	COG2017	converts alpha-aldose to the beta-anomer
I2V18_RS01900	COG0569	domain protein
I2V18_RS01905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I2V18_RS01920	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I2V18_RS01940	COG1028	Short-chain dehydrogenase reductase Sdr
I2V18_RS01955	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I2V18_RS01965	COG0436	Aminotransferase
I2V18_RS01980	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I2V18_RS01985	COG0250	Participates in transcription elongation, termination and antitermination
I2V18_RS01990	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I2V18_RS01995	COG0081	regulation of translation
I2V18_RS02000	COG0515	serine threonine protein kinase
I2V18_RS02005	COG2885	chlorophyll binding
I2V18_RS02010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I2V18_RS02015	COG0222	ribosome binding
I2V18_RS02030	COG0085	RNA polymerase activity
I2V18_RS02035	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I2V18_RS02045	COG0714	Associated with various cellular activities
I2V18_RS02085	COG0433	COG0433 Predicted ATPase
I2V18_RS02085	COG1674	ftsk spoiiie
I2V18_RS02125	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I2V18_RS02130	COG0049	tRNA binding
I2V18_RS02135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I2V18_RS02140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I2V18_RS02190	COG0051	transcription antitermination factor activity, RNA binding
I2V18_RS02200	COG0088	Forms part of the polypeptide exit tunnel
I2V18_RS02205	COG0089	rRNA binding
I2V18_RS02210	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I2V18_RS02215	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I2V18_RS02220	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I2V18_RS02225	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I2V18_RS02230	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I2V18_RS02235	COG0255	Belongs to the universal ribosomal protein uL29 family
I2V18_RS02240	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I2V18_RS02250	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I2V18_RS02255	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I2V18_RS02260	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I2V18_RS02265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I2V18_RS02270	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I2V18_RS02275	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I2V18_RS02285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I2V18_RS02290	COG1841	ribosomal large subunit assembly
I2V18_RS02295	COG0200	Binds to the 23S rRNA
I2V18_RS02305	COG0563	adenylate kinase activity
I2V18_RS02325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I2V18_RS02330	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I2V18_RS02335	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I2V18_RS02340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I2V18_RS02345	COG0202	RNA polymerase activity
I2V18_RS02350	COG0203	ribosomal protein L17
I2V18_RS02360	COG0101	tRNA pseudouridine synthase activity
I2V18_RS02365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I2V18_RS02385	COG1072	(Pantothenic acid kinase))
I2V18_RS02395	COG0736	holo-[acyl-carrier-protein] synthase activity
I2V18_RS02405	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I2V18_RS02410	COG0802	atpase or kinase
I2V18_RS02435	COG1053	succinate dehydrogenase
I2V18_RS02440	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I2V18_RS02450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I2V18_RS02460	COG2949	membrane
I2V18_RS02465	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I2V18_RS02480	COG4585	Histidine kinase
I2V18_RS02485	COG2197	response regulator
I2V18_RS02490	COG4152	abc transporter atp-binding protein
I2V18_RS02495	COG1668	transmembrane transport
I2V18_RS02505	COG0516	GMP reductase activity
I2V18_RS02525	COG0328	RNA-DNA hybrid ribonuclease activity
I2V18_RS02530	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I2V18_RS02540	COG1609	Transcriptional regulator
I2V18_RS02545	COG0673	inositol 2-dehydrogenase activity
I2V18_RS02550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I2V18_RS02575	COG1132	(ABC) transporter
I2V18_RS02590	COG1131	(ABC) transporter
I2V18_RS02605	COG2188	Transcriptional regulator
I2V18_RS02620	COG3718	enzyme involved in inositol metabolism
I2V18_RS02625	COG3962	Belongs to the TPP enzyme family
I2V18_RS02635	COG2801	Transposase and inactivated derivatives
I2V18_RS02665	COG1012	belongs to the aldehyde dehydrogenase family
I2V18_RS02670	COG0673	inositol 2-dehydrogenase activity
I2V18_RS02675	COG1129	ABC transporter
I2V18_RS02680	COG1172	Belongs to the binding-protein-dependent transport system permease family
I2V18_RS02685	COG1879	ABC-type sugar transport system periplasmic component
I2V18_RS02695	COG1082	Xylose isomerase domain protein TIM barrel
I2V18_RS02705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I2V18_RS02705	COG0519	Catalyzes the synthesis of GMP from XMP
I2V18_RS02730	COG0519	Catalyzes the synthesis of GMP from XMP
I2V18_RS02735	COG0667	Aldo Keto reductase
I2V18_RS02760	COG1335	isochorismatase
I2V18_RS02765	COG1136	(ABC) transporter
I2V18_RS02795	COG2197	response regulator
I2V18_RS02810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I2V18_RS02820	COG0356	it plays a direct role in the translocation of protons across the membrane
I2V18_RS02825	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I2V18_RS02830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I2V18_RS02835	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I2V18_RS02840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I2V18_RS02845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I2V18_RS02850	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I2V18_RS02855	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I2V18_RS02865	COG0058	SHG alpha-glucan phosphorylase activity
I2V18_RS02890	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I2V18_RS02895	COG3281	Trehalose synthase
I2V18_RS02900	COG0366	Alpha amylase catalytic
I2V18_RS02920	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I2V18_RS02930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I2V18_RS02935	COG0512	Glutamine amidotransferase of anthranilate synthase
I2V18_RS02940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I2V18_RS02965	COG1725	Transcriptional regulator
I2V18_RS02970	COG1131	(ABC) transporter
I2V18_RS02980	COG0482	sulfurtransferase activity
I2V18_RS03005	COG3480	Lon protease (S16) C-terminal proteolytic domain
I2V18_RS03020	COG1615	UPF0182 protein
I2V18_RS03030	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I2V18_RS03035	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I2V18_RS03050	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I2V18_RS03055	COG1349	DNA-binding transcription factor activity
I2V18_RS03065	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I2V18_RS03065	COG0662	Cupin 2, conserved barrel domain protein
I2V18_RS03080	COG0803	Belongs to the bacterial solute-binding protein 9 family
I2V18_RS03085	COG1121	(ABC) transporter
I2V18_RS03095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I2V18_RS03100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I2V18_RS03110	COG1611	Belongs to the LOG family
I2V18_RS03120	COG4122	O-methyltransferase activity
I2V18_RS03140	COG2239	Acts as a magnesium transporter
I2V18_RS03150	COG1082	Xylose isomerase domain protein TIM barrel
I2V18_RS03165	COG0006	proline dipeptidase activity
I2V18_RS03175	COG2095	MarC family integral membrane protein
I2V18_RS03185	COG0513	Belongs to the DEAD box helicase family
I2V18_RS03200	COG2315	Protein conserved in bacteria
I2V18_RS03205	COG0114	fumarate hydratase activity
I2V18_RS03215	COG1064	alcohol dehydrogenase
I2V18_RS03225	COG1125	glycine betaine transport
I2V18_RS03225	COG0517	IMP dehydrogenase activity
I2V18_RS03230	COG1174	glycine betaine transport
I2V18_RS03235	COG1174	glycine betaine transport
I2V18_RS03255	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I2V18_RS03285	COG1674	ftsk spoiiie
I2V18_RS03290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I2V18_RS03300	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I2V18_RS03305	COG0154	amidase activity
I2V18_RS03310	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I2V18_RS03340	COG0569	domain protein
I2V18_RS03340	COG2985	domain, Protein
I2V18_RS03355	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I2V18_RS03365	COG0473	3-isopropylmalate dehydrogenase activity
I2V18_RS03380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I2V18_RS03385	COG1316	TRANSCRIPTIONal
I2V18_RS03400	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I2V18_RS03460	COG1134	teichoic acid transport
I2V18_RS03480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I2V18_RS03485	COG1086	Polysaccharide biosynthesis protein
I2V18_RS03515	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I2V18_RS03520	COG0842	Transport permease protein
I2V18_RS03520	COG1131	(ABC) transporter
I2V18_RS03520	COG1716	ATPase activity
I2V18_RS03545	COG2884	Cell division ATP-binding protein ftsE
I2V18_RS03550	COG2177	Part of the ABC transporter FtsEX involved in
I2V18_RS03620	COG3617	BRO family, N-terminal domain
I2V18_RS03630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I2V18_RS03630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I2V18_RS03680	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I2V18_RS03705	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I2V18_RS03745	COG0544	peptidyl-prolyl cis-trans isomerase activity
I2V18_RS03770	COG0740	serine-type endopeptidase activity
I2V18_RS03775	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I2V18_RS03780	COG0287	Prephenate dehydrogenase
I2V18_RS03780	COG1605	Chorismate mutase
I2V18_RS03800	COG1132	(ABC) transporter
I2V18_RS03800	COG2375	cellular response to nickel ion
I2V18_RS03805	COG1132	(ABC) transporter
I2V18_RS03810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I2V18_RS03845	COG0285	dihydrofolate synthase activity
I2V18_RS03850	COG0105	UTP biosynthetic process
I2V18_RS03860	COG4152	abc transporter atp-binding protein
I2V18_RS03875	COG1196	nuclear chromosome segregation
I2V18_RS03895	COG1136	(ABC) transporter
I2V18_RS03905	COG2197	response regulator
I2V18_RS03920	COG1115	amino acid carrier protein
I2V18_RS03960	COG1131	(ABC) transporter
I2V18_RS03975	COG1132	(ABC) transporter
I2V18_RS03980	COG1131	(ABC) transporter
I2V18_RS04005	COG1131	(ABC) transporter
I2V18_RS04010	COG0228	four-way junction DNA binding
I2V18_RS04015	COG1837	Belongs to the UPF0109 family
I2V18_RS04025	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I2V18_RS04030	COG0336	Belongs to the RNA methyltransferase TrmD family
I2V18_RS04035	COG0335	large ribosomal subunit rRNA binding
I2V18_RS04040	COG0681	Belongs to the peptidase S26 family
I2V18_RS04045	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I2V18_RS04055	COG0792	nuclease activity
I2V18_RS04070	COG4974	Belongs to the 'phage' integrase family
I2V18_RS04080	COG0052	Belongs to the universal ribosomal protein uS2 family
I2V18_RS04085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I2V18_RS04090	COG0528	UMP kinase activity
I2V18_RS04095	COG0233	cytoplasmic translational termination
I2V18_RS04105	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I2V18_RS04115	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I2V18_RS04120	COG0750	zinc metalloprotease
I2V18_RS04130	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I2V18_RS04140	COG2501	S4 domain
I2V18_RS04145	COG0442	prolyl-tRNA aminoacylation
I2V18_RS04160	COG0779	Required for maturation of 30S ribosomal subunits
I2V18_RS04175	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I2V18_RS04175	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I2V18_RS04185	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I2V18_RS04190	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I2V18_RS04195	COG0196	riboflavin kinase activity
I2V18_RS04205	COG1454	alcohol dehydrogenase
I2V18_RS04210	COG1185	polyribonucleotide nucleotidyltransferase activity
I2V18_RS04215	COG0612	Peptidase, M16
I2V18_RS04220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I2V18_RS04245	COG0318	PFAM AMP-dependent synthetase and ligase
I2V18_RS04265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I2V18_RS04275	COG2001	Belongs to the MraZ family
I2V18_RS04280	COG0275	rRNA processing
I2V18_RS04290	COG0768	penicillin binding
I2V18_RS04295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I2V18_RS04300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I2V18_RS04305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I2V18_RS04310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I2V18_RS04315	COG0772	Belongs to the SEDS family
I2V18_RS04325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I2V18_RS04335	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I2V18_RS04340	COG1496	oxidoreductase activity
I2V18_RS04345	COG1799	cell septum assembly
I2V18_RS04355	COG3599	regulation of cell shape
I2V18_RS04360	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I2V18_RS04380	COG0587	DNA-directed DNA polymerase activity
I2V18_RS04425	COG0514	ATP-dependent DNA helicase (RecQ)
I2V18_RS04440	COG0025	NhaP-type Na H and K H
I2V18_RS04445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I2V18_RS04450	COG0131	Imidazoleglycerol-phosphate dehydratase
I2V18_RS04470	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I2V18_RS04485	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I2V18_RS04490	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I2V18_RS04495	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I2V18_RS04505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I2V18_RS04520	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I2V18_RS04525	COG0072	phenylalanine-tRNA ligase activity
I2V18_RS04525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I2V18_RS04535	COG1438	arginine binding
I2V18_RS04540	COG0137	argininosuccinate synthase activity
I2V18_RS04550	COG0165	Argininosuccinate lyase
I2V18_RS04555	COG2094	Belongs to the DNA glycosylase MPG family
I2V18_RS04570	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I2V18_RS04595	COG0647	UMP catabolic process
I2V18_RS04610	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I2V18_RS04615	COG0497	DNA recombination
I2V18_RS04645	COG0494	nUDIX hydrolase
I2V18_RS04655	COG0719	Fe-S assembly protein
I2V18_RS04675	COG0822	iron-sulfur transferase activity
I2V18_RS04680	COG2151	metal-sulfur cluster biosynthetic enzyme
I2V18_RS04710	COG0167	dihydroorotate dehydrogenase activity
I2V18_RS04730	COG1929	Belongs to the glycerate kinase type-1 family
I2V18_RS04740	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I2V18_RS04745	COG0358	DNA primase activity
I2V18_RS04780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I2V18_RS04800	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I2V18_RS04830	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I2V18_RS04840	COG3022	response to hydroperoxide
I2V18_RS04860	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I2V18_RS04865	COG0174	glutamine synthetase
I2V18_RS04870	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I2V18_RS04880	COG1126	abc transporter atp-binding protein
I2V18_RS04885	COG0765	amino acid transport
I2V18_RS04905	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I2V18_RS04910	COG0321	lipoyl(octanoyl) transferase activity
I2V18_RS04930	COG0508	dehydrogenase complex catalyzes the overall conversion of
I2V18_RS04935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I2V18_RS04940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I2V18_RS04960	COG1131	(ABC) transporter
I2V18_RS04980	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I2V18_RS04985	COG1882	Formate acetyltransferase
I2V18_RS05000	COG0446	pyridine nucleotide-disulphide oxidoreductase
I2V18_RS05035	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I2V18_RS05050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I2V18_RS05060	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I2V18_RS05065	COG1560	Kdo2-lipid A biosynthetic process
I2V18_RS05070	COG0438	transferase activity, transferring glycosyl groups
I2V18_RS05090	COG0217	transcriptional regulatory protein
I2V18_RS05095	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I2V18_RS05100	COG0632	four-way junction helicase activity
I2V18_RS05105	COG2255	four-way junction helicase activity
I2V18_RS05115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I2V18_RS05120	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I2V18_RS05125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I2V18_RS05130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I2V18_RS05140	COG1196	nuclear chromosome segregation
I2V18_RS05145	COG2226	methyltransferase
I2V18_RS05195	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I2V18_RS05210	COG0009	L-threonylcarbamoyladenylate synthase
I2V18_RS05215	COG2409	Drug exporters of the RND superfamily
I2V18_RS05225	COG0730	response to heat
I2V18_RS05230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I2V18_RS05240	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I2V18_RS05250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I2V18_RS05255	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I2V18_RS05265	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I2V18_RS05275	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I2V18_RS05280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I2V18_RS05295	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I2V18_RS05300	COG0540	Belongs to the ATCase OTCase family
I2V18_RS05305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I2V18_RS05315	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I2V18_RS05320	COG0284	orotidine-5'-phosphate decarboxylase activity
I2V18_RS05325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I2V18_RS05330	COG0194	GDP metabolic process
I2V18_RS05335	COG1758	RNA polymerase activity
I2V18_RS05345	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I2V18_RS05355	COG1470	cell adhesion involved in biofilm formation
I2V18_RS05355	COG0366	Alpha amylase catalytic
I2V18_RS05365	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I2V18_RS05375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I2V18_RS05380	COG4770	biotin carboxylase activity
I2V18_RS05385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I2V18_RS05390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I2V18_RS05400	COG2337	Toxic component of a toxin-antitoxin (TA) module
I2V18_RS05420	COG2376	Dihydroxyacetone kinase
I2V18_RS05425	COG1461	Dihydroxyacetone kinase
I2V18_RS05430	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I2V18_RS05430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2V18_RS05430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I2V18_RS05435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I2V18_RS05460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I2V18_RS05465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I2V18_RS05470	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I2V18_RS05475	COG0140	phosphoribosyl-ATP diphosphatase activity
I2V18_RS05480	COG1105	Belongs to the carbohydrate kinase PfkB family
I2V18_RS05505	COG0805	protein transport
I2V18_RS05530	COG1216	Glycosyl transferase, family 2
I2V18_RS05540	COG0205	6-phosphofructokinase activity
I2V18_RS05555	COG1263	PTS System
I2V18_RS05555	COG2190	(PTS) system
I2V18_RS05555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2V18_RS05560	COG1621	beta-fructofuranosidase activity
I2V18_RS05565	COG0443	Heat shock 70 kDa protein
I2V18_RS05585	COG1716	ATPase activity
I2V18_RS05610	COG0662	Cupin 2, conserved barrel domain protein
I2V18_RS05630	COG0166	Belongs to the GPI family
I2V18_RS05635	COG1160	GTP binding
I2V18_RS05650	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I2V18_RS05655	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I2V18_RS05670	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I2V18_RS05675	COG0149	triose-phosphate isomerase activity
I2V18_RS05685	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I2V18_RS05690	COG1481	regulation of sporulation
I2V18_RS05700	COG1660	Displays ATPase and GTPase activities
I2V18_RS05710	COG0322	excinuclease ABC activity
I2V18_RS05745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I2V18_RS05770	COG0556	nucleotide-excision repair
I2V18_RS05775	COG0237	dephospho-CoA kinase activity
I2V18_RS05780	COG0539	negative regulation of cytoplasmic translation
I2V18_RS05810	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I2V18_RS05815	COG0134	indole-3-glycerol-phosphate synthase activity
I2V18_RS05820	COG1297	OPT oligopeptide transporter protein
I2V18_RS05840	COG0107	imidazoleglycerol-phosphate synthase activity
I2V18_RS05855	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I2V18_RS05865	COG4122	O-methyltransferase activity
I2V18_RS05870	COG1222	aaa ATPase
I2V18_RS05885	COG1994	Peptidase M50
I2V18_RS05885	COG0517	IMP dehydrogenase activity
I2V18_RS05895	COG0656	L-ascorbic acid biosynthetic process
I2V18_RS05905	COG1252	NADH dehydrogenase
I2V18_RS05915	COG1136	(ABC) transporter
I2V18_RS05920	COG0577	efflux transmembrane transporter activity
I2V18_RS05950	COG0587	DNA-directed DNA polymerase activity
I2V18_RS05960	COG0833	amino acid
I2V18_RS05985	COG0671	phosphoesterase, PA-phosphatase related
I2V18_RS06005	COG1881	PFAM PEBP family protein
I2V18_RS06015	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I2V18_RS06030	COG0823	Involved in the tonB-independent uptake of proteins
I2V18_RS06035	COG1609	Transcriptional regulator
I2V18_RS06040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I2V18_RS06045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I2V18_RS06050	COG0531	amino acid
I2V18_RS06055	COG0569	domain protein
I2V18_RS06100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I2V18_RS06110	COG0187	DNA topoisomerase II activity
I2V18_RS06120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I2V18_RS06125	COG0142	geranyltranstransferase activity
I2V18_RS06130	COG0515	serine threonine protein kinase
I2V18_RS06130	COG2815	serine threonine protein kinase
I2V18_RS06135	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I2V18_RS06180	COG0488	(ABC) transporter
I2V18_RS06190	COG2326	polyphosphate kinase activity
I2V18_RS06210	COG1119	ATPase activity
I2V18_RS06220	COG0297	glycogen (starch) synthase activity
I2V18_RS06230	COG0560	Phosphoserine phosphatase
I2V18_RS06240	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I2V18_RS06260	COG0423	glycine-tRNA ligase activity
I2V18_RS06280	COG1121	(ABC) transporter
I2V18_RS06285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I2V18_RS06305	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I2V18_RS06310	COG1381	Involved in DNA repair and RecF pathway recombination
I2V18_RS06315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I2V18_RS06330	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I2V18_RS06340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I2V18_RS06360	COG1309	transcriptional regulator
I2V18_RS06370	COG3311	Transcriptional regulator
I2V18_RS06420	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I2V18_RS06430	COG0484	heat shock protein binding
I2V18_RS06435	COG1420	regulation of RNA biosynthetic process
I2V18_RS06495	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I2V18_RS06500	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I2V18_RS06505	COG0481	GTPase activity
I2V18_RS06510	COG2197	response regulator
I2V18_RS06515	COG4585	Histidine kinase
I2V18_RS06540	COG0268	Binds directly to 16S ribosomal RNA
I2V18_RS06545	COG4868	Belongs to the UPF0371 family
I2V18_RS06550	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I2V18_RS06575	COG0433	COG0433 Predicted ATPase
I2V18_RS06580	COG0495	leucyl-tRNA aminoacylation
I2V18_RS06665	COG0733	neurotransmitter:sodium symporter activity
I2V18_RS06710	COG0406	alpha-ribazole phosphatase activity
I2V18_RS06715	COG0799	negative regulation of ribosome biogenesis
I2V18_RS06725	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I2V18_RS06745	COG1349	DNA-binding transcription factor activity
I2V18_RS06750	COG5426	von Willebrand factor, type A
I2V18_RS06760	COG0438	transferase activity, transferring glycosyl groups
I2V18_RS06765	COG0438	transferase activity, transferring glycosyl groups
I2V18_RS06770	COG1132	(ABC) transporter
I2V18_RS06785	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I2V18_RS06805	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I2V18_RS06810	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I2V18_RS06815	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I2V18_RS06820	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I2V18_RS06825	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I2V18_RS06840	COG0803	Belongs to the bacterial solute-binding protein 9 family
I2V18_RS06840	COG0803	Belongs to the bacterial solute-binding protein 9 family
I2V18_RS06850	COG1121	(ABC) transporter
I2V18_RS06855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I2V18_RS06860	COG1530	ribonuclease E activity
I2V18_RS06865	COG1271	oxidase subunit
I2V18_RS06870	COG1294	oxidase, subunit
I2V18_RS06875	COG4988	ABC transporter
I2V18_RS06880	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I2V18_RS06895	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I2V18_RS06900	COG0571	ribonuclease III activity
I2V18_RS06915	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I2V18_RS06940	COG0133	tryptophan synthase activity
I2V18_RS06955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I2V18_RS06955	COG0515	serine threonine protein kinase
I2V18_RS06965	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I2V18_RS06975	COG1181	Belongs to the D-alanine--D-alanine ligase family
I2V18_RS06985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I2V18_RS07015	COG1461	Dihydroxyacetone kinase
I2V18_RS07020	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I2V18_RS07030	COG1181	Belongs to the D-alanine--D-alanine ligase family
I2V18_RS07040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I2V18_RS07050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I2V18_RS07055	COG0066	3-isopropylmalate dehydratase activity
I2V18_RS07060	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I2V18_RS07080	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I2V18_RS07090	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I2V18_RS07105	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I2V18_RS07115	COG1114	Component of the transport system for branched-chain amino acids
I2V18_RS07120	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I2V18_RS07125	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I2V18_RS07145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I2V18_RS07150	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I2V18_RS07165	COG2137	regulation of response to DNA damage stimulus
I2V18_RS07170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I2V18_RS07180	COG1396	sequence-specific DNA binding
I2V18_RS07185	COG1058	Belongs to the CinA family
I2V18_RS07185	COG1546	Belongs to the CinA family
I2V18_RS07200	COG1674	ftsk spoiiie
I2V18_RS07210	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I2V18_RS07235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I2V18_RS07245	COG0179	Fumarylacetoacetate (FAA) hydrolase
I2V18_RS07255	COG1115	amino acid carrier protein
I2V18_RS07260	COG1115	amino acid carrier protein
I2V18_RS07265	COG1115	amino acid carrier protein
I2V18_RS07275	COG1136	(ABC) transporter
I2V18_RS07285	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I2V18_RS07295	COG3304	Inner membrane component domain
I2V18_RS07350	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I2V18_RS07355	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I2V18_RS07390	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I2V18_RS07400	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I2V18_RS07420	COG0363	glucosamine-6-phosphate deaminase activity
I2V18_RS07440	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I2V18_RS07445	COG1940	carbohydrate kinase activity
I2V18_RS07450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I2V18_RS07455	COG4608	Belongs to the ABC transporter superfamily
I2V18_RS07460	COG0444	Belongs to the ABC transporter superfamily
I2V18_RS07465	COG0601	transmembrane transport
I2V18_RS07470	COG0747	negative chemotaxis
I2V18_RS07475	COG2188	Transcriptional regulator
I2V18_RS07480	COG0657	acetylesterase activity
I2V18_RS07530	COG1739	Uncharacterized protein family UPF0029
I2V18_RS07540	COG1045	serine acetyltransferase
I2V18_RS07550	COG2801	Transposase and inactivated derivatives
I2V18_RS07575	COG0698	ribose 5-phosphate isomerase
I2V18_RS07580	COG3590	peptidase
I2V18_RS07600	COG1263	PTS System
I2V18_RS07605	COG2188	Transcriptional regulator
I2V18_RS07615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2V18_RS07630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I2V18_RS07655	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I2V18_RS07660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I2V18_RS07670	COG0813	purine-nucleoside phosphorylase activity
I2V18_RS07675	COG2390	Transcriptional regulator
I2V18_RS07690	COG1079	Belongs to the binding-protein-dependent transport system permease family
I2V18_RS07695	COG4603	Belongs to the binding-protein-dependent transport system permease family
I2V18_RS07700	COG3845	ABC transporter
I2V18_RS07705	COG1744	ABC transporter substrate-binding protein PnrA-like
I2V18_RS07710	COG0583	DNA-binding transcription factor activity
I2V18_RS07760	COG0210	DNA helicase
I2V18_RS07800	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I2V18_RS07805	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I2V18_RS07810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I2V18_RS07815	COG0254	rRNA binding
I2V18_RS07820	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I2V18_RS07840	COG1857	crispr-associated protein
I2V18_RS07855	COG1518	maintenance of DNA repeat elements
I2V18_RS07920	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I2V18_RS07930	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I2V18_RS07960	COG0395	ABC-type sugar transport system, permease component
I2V18_RS07965	COG1175	transmembrane transport
I2V18_RS07975	COG0039	L-malate dehydrogenase activity
I2V18_RS07995	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I2V18_RS08030	COG0045	succinate-CoA ligase (ADP-forming) activity
I2V18_RS08035	COG0205	6-phosphofructokinase activity
I2V18_RS08045	COG0778	Nitroreductase
I2V18_RS08065	COG1136	(ABC) transporter
I2V18_RS08100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I2V18_RS08105	COG0254	rRNA binding
I2V18_RS08115	COG0701	Predicted permease
I2V18_RS08125	COG0840	transmembrane signaling receptor activity
I2V18_RS08130	COG0083	homoserine kinase activity
I2V18_RS08135	COG0460	homoserine dehydrogenase
I2V18_RS08160	COG1122	ATPase activity
I2V18_RS08175	COG0018	arginyl-trna synthetase
I2V18_RS08190	COG0584	glycerophosphoryl diester phosphodiesterase
I2V18_RS08195	COG0739	heme binding
I2V18_RS08195	COG0741	lytic transglycosylase activity
I2V18_RS08195	COG1196	nuclear chromosome segregation
I2V18_RS08215	COG0567	Dehydrogenase, E1 component
I2V18_RS08215	COG0508	dehydrogenase complex catalyzes the overall conversion of
I2V18_RS08230	COG1595	DNA-templated transcription, initiation
I2V18_RS08240	COG2838	Isocitrate dehydrogenase
I2V18_RS08250	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I2V18_RS08255	COG1162	GTPase activity
I2V18_RS08270	COG0577	efflux transmembrane transporter activity
I2V18_RS08270	COG1136	(ABC) transporter
I2V18_RS08275	COG0577	efflux transmembrane transporter activity
I2V18_RS08280	COG1968	undecaprenyl-diphosphatase activity
I2V18_RS08290	COG0420	3'-5' exonuclease activity
I2V18_RS08295	COG0419	ATPase involved in DNA repair
I2V18_RS08335	COG0653	protein targeting
I2V18_RS08340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I2V18_RS08345	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I2V18_RS08350	COG5401	PFAM Sporulation and spore germination
I2V18_RS08355	COG5002	protein histidine kinase activity
I2V18_RS08355	COG5000	phosphorelay sensor kinase activity
I2V18_RS08380	COG0714	Associated with various cellular activities
I2V18_RS08385	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I2V18_RS08400	COG2835	tetraacyldisaccharide 4'-kinase activity
I2V18_RS08450	COG3475	LICD family
I2V18_RS08455	COG1215	transferase activity, transferring glycosyl groups
I2V18_RS08465	COG3475	LICD family
I2V18_RS08470	COG0697	spore germination
I2V18_RS08495	COG0438	transferase activity, transferring glycosyl groups
I2V18_RS08505	COG1215	transferase activity, transferring glycosyl groups
I2V18_RS08545	COG1088	dTDP-glucose 4,6-dehydratase activity
I2V18_RS08575	COG1316	TRANSCRIPTIONal
I2V18_RS08580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I2V18_RS08585	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I2V18_RS08615	COG0745	RESPONSE REGULATOR receiver
I2V18_RS08635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I2V18_RS08660	COG1132	(ABC) transporter
I2V18_RS08670	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I2V18_RS08745	COG1666	GTP binding
I2V18_RS08750	COG0501	Belongs to the peptidase M48B family
I2V18_RS08755	COG0686	Belongs to the AlaDH PNT family
I2V18_RS08770	COG0142	geranyltranstransferase activity
I2V18_RS08775	COG1007	ATP synthesis coupled electron transport
I2V18_RS08785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I2V18_RS08790	COG0713	ATP synthesis coupled electron transport
I2V18_RS08800	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I2V18_RS08805	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I2V18_RS08810	COG1034	ATP synthesis coupled electron transport
I2V18_RS08815	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I2V18_RS08825	COG0649	NAD binding
I2V18_RS08830	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I2V18_RS08835	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I2V18_RS08840	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I2V18_RS08845	COG2226	methyltransferase
I2V18_RS08860	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I2V18_RS08865	COG4948	Mandelate Racemase Muconate Lactonizing
I2V18_RS08875	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I2V18_RS08920	COG0406	alpha-ribazole phosphatase activity
I2V18_RS08925	COG2171	N-acyltransferase activity
I2V18_RS08965	COG2720	vancomycin resistance protein
I2V18_RS08970	COG1217	gtp-binding protein TYPA
I2V18_RS09000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I2V18_RS09020	COG4667	esterase of the alpha-beta hydrolase superfamily
I2V18_RS09025	COG1362	aminopeptidase activity
I2V18_RS09065	COG3422	double-strand break repair
I2V18_RS09070	COG1376	ErfK ybiS ycfS ynhG family protein
I2V18_RS09095	COG1959	2 iron, 2 sulfur cluster binding
I2V18_RS09100	COG0789	Transcriptional regulator
I2V18_RS09145	COG0012	GTP binding
I2V18_RS09155	COG1322	Protein conserved in bacteria
I2V18_RS09170	COG1570	exodeoxyribonuclease VII activity
I2V18_RS09175	COG1722	exodeoxyribonuclease VII activity
I2V18_RS09190	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I2V18_RS09200	COG2326	polyphosphate kinase activity
I2V18_RS09205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I2V18_RS09210	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I2V18_RS09220	COG0431	NADPH-dependent FMN reductase
I2V18_RS09225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I2V18_RS09230	COG0129	dihydroxy-acid dehydratase activity
I2V18_RS09235	COG0545	Peptidyl-prolyl cis-trans isomerase
I2V18_RS09260	COG2197	response regulator
I2V18_RS09270	COG0193	aminoacyl-tRNA hydrolase activity
I2V18_RS09275	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I2V18_RS09280	COG0710	3-dehydroquinate dehydratase activity
I2V18_RS09300	COG0148	phosphopyruvate hydratase activity
I2V18_RS09360	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I2V18_RS09360	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I2V18_RS09375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I2V18_RS09395	COG1309	transcriptional regulator
I2V18_RS09405	COG0714	Associated with various cellular activities
I2V18_RS09440	COG0488	(ABC) transporter
I2V18_RS09445	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I2V18_RS09450	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I2V18_RS09455	COG1388	LysM domain
I2V18_RS09470	COG0084	hydrolase, TatD family'
I2V18_RS09475	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I2V18_RS09535	COG1131	(ABC) transporter
I2V18_RS09550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I2V18_RS09560	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I2V18_RS09570	COG1970	mechanosensitive ion channel activity
I2V18_RS09610	COG2252	PERMEase
I2V18_RS09625	COG1432	Conserved Protein
I2V18_RS09635	COG1122	ATPase activity
I2V18_RS09640	COG0577	efflux transmembrane transporter activity
I2V18_RS09640	COG1136	(ABC) transporter
I2V18_RS09690	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I2V18_RS09695	COG1162	GTPase activity
I2V18_RS09725	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I2V18_RS09745	COG0315	cyclic pyranopterin monophosphate synthase activity
I2V18_RS09755	COG1546	Belongs to the CinA family
I2V18_RS09755	COG1058	Belongs to the CinA family
I2V18_RS09770	COG1140	nitrate reductase beta subunit
I2V18_RS09795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I2V18_RS09815	COG1136	(ABC) transporter
I2V18_RS09815	COG0577	efflux transmembrane transporter activity
I2V18_RS09850	COG0577	efflux transmembrane transporter activity
I2V18_RS09850	COG1136	(ABC) transporter
I2V18_RS09855	COG1136	(ABC) transporter
I2V18_RS09855	COG0577	efflux transmembrane transporter activity
I2V18_RS09860	COG0483	inositol monophosphate 1-phosphatase activity
I2V18_RS09865	COG1968	undecaprenyl-diphosphatase activity
I2V18_RS09875	COG1061	Type III restriction enzyme res subunit
I2V18_RS09885	COG1842	Phage shock protein A
I2V18_RS09895	COG0745	RESPONSE REGULATOR receiver
I2V18_RS09900	COG2205	protein histidine kinase activity
I2V18_RS09915	COG0459	protein refolding
I2V18_RS09925	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I2V18_RS09930	COG1329	Transcriptional regulator
I2V18_RS09935	COG0745	RESPONSE REGULATOR receiver
I2V18_RS09940	COG5002	protein histidine kinase activity
I2V18_RS09945	COG0588	phosphoglycerate mutase activity
I2V18_RS09965	COG0252	asparaginase activity
I2V18_RS09970	COG0596	Alpha beta hydrolase
I2V18_RS09975	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I2V18_RS09980	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I2V18_RS09990	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I2V18_RS09995	COG0549	Belongs to the carbamate kinase family
I2V18_RS10000	COG1834	amidinotransferase
I2V18_RS10015	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I2V18_RS10030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I2V18_RS10030	COG1754	DNA topoisomerase type I activity
I2V18_RS10045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I2V18_RS10045	COG1754	DNA topoisomerase type I activity
I2V18_RS10050	COG0745	RESPONSE REGULATOR receiver
I2V18_RS10075	COG2890	protein-(glutamine-N5) methyltransferase activity
I2V18_RS10090	COG0450	alkyl hydroperoxide reductase
I2V18_RS10095	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I2V18_RS10140	COG0596	Alpha beta hydrolase
I2V18_RS10170	COG1131	(ABC) transporter
I2V18_RS10200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2V18_RS10205	COG1408	metallophosphoesterase
I2V18_RS10215	COG1597	lipid kinase activity
I2V18_RS10245	COG1918	ferrous iron import across plasma membrane
I2V18_RS10245	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I2V18_RS10255	COG0535	radical SAM domain protein
I2V18_RS10260	COG3253	May function as heme-dependent peroxidase
I2V18_RS10260	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I2V18_RS10265	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I2V18_RS10270	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I2V18_RS10275	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I2V18_RS10285	COG0181	hydroxymethylbilane synthase activity
I2V18_RS10295	COG0113	porphobilinogen synthase activity
I2V18_RS10305	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I2V18_RS10310	COG0531	amino acid
I2V18_RS10320	COG1121	(ABC) transporter
I2V18_RS10325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I2V18_RS10330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I2V18_RS10340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I2V18_RS10360	COG1131	(ABC) transporter
I2V18_RS10370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I2V18_RS10410	COG2233	PERMEase
I2V18_RS10450	COG1643	Atp-dependent helicase
I2V18_RS10465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I2V18_RS10470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I2V18_RS10490	COG2375	cellular response to nickel ion
I2V18_RS10490	COG1132	(ABC) transporter
I2V18_RS10495	COG1132	(ABC) transporter
I2V18_RS10520	COG0471	metal ion transport
I2V18_RS10540	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I2V18_RS10545	COG0395	ABC-type sugar transport system, permease component
I2V18_RS10550	COG1175	transmembrane transport
I2V18_RS10570	COG1609	Transcriptional regulator
I2V18_RS10575	COG1653	transport
I2V18_RS10580	COG0561	phosphatase activity
I2V18_RS10585	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I2V18_RS10615	COG5444	nuclease activity
I2V18_RS10635	COG0477	Major facilitator Superfamily
I2V18_RS10655	COG3588	fructose-bisphosphate aldolase
I2V18_RS10675	COG0251	oxidation-reduction process
I2V18_RS10690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I2V18_RS10695	COG1950	PFAM Membrane protein of
I2V18_RS10720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I2V18_RS10730	COG1609	Transcriptional regulator
I2V18_RS10750	COG1175	transmembrane transport
I2V18_RS10755	COG0395	ABC-type sugar transport system, permease component
I2V18_RS10785	COG1131	(ABC) transporter
I2V18_RS10810	COG1113	amino acid transport
I2V18_RS10835	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I2V18_RS10835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I2V18_RS10925	COG2375	cellular response to nickel ion
I2V18_RS10925	COG1132	(ABC) transporter
I2V18_RS10930	COG2375	cellular response to nickel ion
I2V18_RS10930	COG1132	(ABC) transporter
I2V18_RS10935	COG1309	transcriptional regulator
I2V18_RS10945	COG0617	tRNA 3'-terminal CCA addition
I2V18_RS10965	COG0492	ferredoxin-NADP+ reductase activity
I2V18_RS10970	COG3118	belongs to the thioredoxin family
I2V18_RS10975	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I2V18_RS10980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I2V18_RS10985	COG1181	Belongs to the D-alanine--D-alanine ligase family
I2V18_RS11000	COG0357	Ribosomal RNA small subunit methyltransferase G
I2V18_RS11010	COG0706	membrane insertase activity
I2V18_RS11015	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I2V18_RS11020	COG0594	ribonuclease P activity
I2V18_RS11025	COG0230	Belongs to the bacterial ribosomal protein bL34 family