locus-tag	class	description
AFR_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFR_RS00010	COG0592	DNA-directed DNA polymerase activity
AFR_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AFR_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AFR_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AFR_RS00040	COG0187	DNA topoisomerase II activity
AFR_RS00045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AFR_RS00075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AFR_RS00100	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AFR_RS00115	COG0442	prolyl-tRNA aminoacylation
AFR_RS00130	COG1595	DNA-templated transcription, initiation
AFR_RS00160	COG0326	Molecular chaperone. Has ATPase activity
AFR_RS00175	COG0439	Biotin carboxylase
AFR_RS00180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFR_RS00195	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AFR_RS00200	COG1960	acyl-CoA dehydrogenase activity
AFR_RS00210	COG1846	Transcriptional regulator
AFR_RS00215	COG2353	YceI-like domain
AFR_RS00260	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AFR_RS00265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFR_RS00275	COG1716	ATPase activity
AFR_RS00275	COG1716	ATPase activity
AFR_RS00280	COG1716	ATPase activity
AFR_RS00295	COG0768	penicillin binding
AFR_RS00300	COG0515	serine threonine protein kinase
AFR_RS00305	COG0515	serine threonine protein kinase
AFR_RS00305	COG2815	serine threonine protein kinase
AFR_RS00335	COG0247	lactate metabolic process
AFR_RS00335	COG2181	nitrate reductase activity
AFR_RS00400	COG0717	Belongs to the dCTP deaminase family
AFR_RS00430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AFR_RS00445	COG1960	acyl-CoA dehydrogenase activity
AFR_RS00460	COG0702	epimerase
AFR_RS00490	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFR_RS00495	COG0022	dehydrogenase e1 component
AFR_RS00530	COG0443	Heat shock 70 kDa protein
AFR_RS00535	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AFR_RS00540	COG0484	heat shock protein binding
AFR_RS00545	COG0789	Transcriptional regulator
AFR_RS00565	COG2814	Major facilitator Superfamily
AFR_RS00575	COG0542	response to heat
AFR_RS00600	COG0640	Transcriptional regulator
AFR_RS00610	COG0586	Pfam SNARE associated Golgi protein
AFR_RS00615	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AFR_RS00625	COG1595	DNA-templated transcription, initiation
AFR_RS00695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AFR_RS00700	COG0151	Belongs to the GarS family
AFR_RS00720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AFR_RS00730	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFR_RS00735	COG0047	phosphoribosylformylglycinamidine synthase activity
AFR_RS00740	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFR_RS00760	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AFR_RS00765	COG0641	radical SAM
AFR_RS00825	COG2050	protein possibly involved in aromatic compounds catabolism
AFR_RS00865	COG4941	Belongs to the sigma-70 factor family
AFR_RS00870	COG3795	YCII-related domain
AFR_RS00910	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AFR_RS00920	COG0142	geranyltranstransferase activity
AFR_RS00945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFR_RS00985	COG0277	FAD linked oxidase domain protein
AFR_RS01005	COG0438	transferase activity, transferring glycosyl groups
AFR_RS01020	COG1295	ribonuclease BN
AFR_RS01080	COG1309	transcriptional regulator
AFR_RS01085	COG4941	Belongs to the sigma-70 factor family
AFR_RS01095	COG3655	Transcriptional regulator
AFR_RS01120	COG0583	DNA-binding transcription factor activity
AFR_RS01130	COG0667	Aldo Keto reductase
AFR_RS01150	COG2205	protein histidine kinase activity
AFR_RS01170	COG0577	efflux transmembrane transporter activity
AFR_RS01170	COG1136	(ABC) transporter
AFR_RS01175	COG0577	efflux transmembrane transporter activity
AFR_RS01175	COG1136	(ABC) transporter
AFR_RS01220	COG1309	transcriptional regulator
AFR_RS01250	COG1970	mechanosensitive ion channel activity
AFR_RS01260	COG1366	Belongs to the anti-sigma-factor antagonist family
AFR_RS01265	COG1366	Belongs to the anti-sigma-factor antagonist family
AFR_RS01270	COG2172	sigma factor antagonist activity
AFR_RS01285	COG0745	RESPONSE REGULATOR receiver
AFR_RS01295	COG1136	(ABC) transporter
AFR_RS01315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFR_RS01315	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFR_RS01320	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AFR_RS01335	COG0463	Glycosyl transferase, family 2
AFR_RS01345	COG0784	Response regulator, receiver
AFR_RS01345	COG2205	protein histidine kinase activity
AFR_RS01365	COG1366	Belongs to the anti-sigma-factor antagonist family
AFR_RS01370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AFR_RS01375	COG0406	alpha-ribazole phosphatase activity
AFR_RS01380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFR_RS01385	COG0785	Cytochrome C biogenesis protein
AFR_RS01395	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AFR_RS01400	COG1132	(ABC) transporter
AFR_RS01405	COG1132	(ABC) transporter
AFR_RS01420	COG1653	transport
AFR_RS01430	COG0366	Alpha amylase catalytic
AFR_RS01450	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AFR_RS01460	COG1595	DNA-templated transcription, initiation
AFR_RS01470	COG0163	prenyltransferase activity
AFR_RS01480	COG1522	sequence-specific DNA binding
AFR_RS01485	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AFR_RS01500	COG0513	Belongs to the DEAD box helicase family
AFR_RS01515	COG0791	NLP P60 protein
AFR_RS01515	COG3883	PFAM NLP P60 protein
AFR_RS01520	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AFR_RS01570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFR_RS01575	COG1120	ATPase activity
AFR_RS01590	COG1131	(ABC) transporter
AFR_RS01610	COG3973	AAA domain
AFR_RS01620	COG2814	Major facilitator Superfamily
AFR_RS01625	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AFR_RS01635	COG0463	Glycosyl transferase, family 2
AFR_RS01650	COG0667	Aldo Keto reductase
AFR_RS01660	COG4279	zinc finger
AFR_RS01665	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AFR_RS01680	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AFR_RS01710	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFR_RS01715	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFR_RS01720	COG0649	NAD binding
AFR_RS01735	COG1034	ATP synthesis coupled electron transport
AFR_RS01740	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AFR_RS01745	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFR_RS01755	COG0713	ATP synthesis coupled electron transport
AFR_RS01770	COG1007	ATP synthesis coupled electron transport
AFR_RS01775	COG0142	geranyltranstransferase activity
AFR_RS01810	COG1950	PFAM Membrane protein of
AFR_RS01820	COG4842	Belongs to the WXG100 family
AFR_RS01840	COG0596	Alpha beta hydrolase
AFR_RS01865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFR_RS01925	COG1205	dead DEAH box helicase
AFR_RS01925	COG1111	helicase
AFR_RS01930	COG1366	Belongs to the anti-sigma-factor antagonist family
AFR_RS01940	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AFR_RS01955	COG1754	DNA topoisomerase type I activity
AFR_RS01955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFR_RS01965	COG1309	transcriptional regulator
AFR_RS01975	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AFR_RS01980	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AFR_RS02005	COG1774	PSP1 C-terminal conserved region
AFR_RS02010	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AFR_RS02040	COG0738	Major facilitator superfamily
AFR_RS02045	COG3226	Transcriptional regulator
AFR_RS02055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFR_RS02100	COG0693	protein deglycase activity
AFR_RS02110	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AFR_RS02115	COG3285	dna ligase
AFR_RS02115	COG1793	dna ligase
AFR_RS02120	COG3285	dna ligase
AFR_RS02120	COG1793	dna ligase
AFR_RS02135	COG1061	Type III restriction enzyme res subunit
AFR_RS02150	COG0546	phosphoglycolate phosphatase activity
AFR_RS02155	COG1278	Cold shock
AFR_RS02160	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AFR_RS02165	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AFR_RS02170	COG2814	Major facilitator Superfamily
AFR_RS02185	COG2252	PERMEase
AFR_RS02190	COG1846	Transcriptional regulator
AFR_RS02195	COG2814	Major facilitator Superfamily
AFR_RS02205	COG2186	Transcriptional regulator
AFR_RS02210	COG2807	transmembrane transport
AFR_RS02245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFR_RS02250	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AFR_RS02260	COG0259	pyridoxamine-phosphate oxidase activity
AFR_RS02270	COG2017	converts alpha-aldose to the beta-anomer
AFR_RS02285	COG1960	acyl-CoA dehydrogenase activity
AFR_RS02305	COG1216	Glycosyl transferase, family 2
AFR_RS02305	COG1442	glycosyl transferase family 8
AFR_RS02310	COG3842	ATPase activity
AFR_RS02340	COG1134	teichoic acid transport
AFR_RS02340	COG1388	LysM domain
AFR_RS02350	COG1309	transcriptional regulator
AFR_RS02385	COG3384	dioxygenase
AFR_RS02455	COG0438	transferase activity, transferring glycosyl groups
AFR_RS02475	COG1595	DNA-templated transcription, initiation
AFR_RS02490	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFR_RS02495	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFR_RS02500	COG1129	ABC transporter
AFR_RS02595	COG1674	ftsk spoiiie
AFR_RS02615	COG0464	growth
AFR_RS02620	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AFR_RS02625	COG3903	Transcriptional regulator
AFR_RS02625	COG3629	intracellular signal transduction
AFR_RS02630	COG3629	intracellular signal transduction
AFR_RS02630	COG3903	Transcriptional regulator
AFR_RS02640	COG2197	response regulator
AFR_RS02675	COG0477	Major facilitator Superfamily
AFR_RS02680	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS02685	COG0745	RESPONSE REGULATOR receiver
AFR_RS02720	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
AFR_RS02735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AFR_RS02740	COG1086	Polysaccharide biosynthesis protein
AFR_RS02770	COG0463	Glycosyl transferase, family 2
AFR_RS02795	COG0604	alcohol dehydrogenase
AFR_RS02820	COG2197	response regulator
AFR_RS02835	COG3237	CsbD-like
AFR_RS02845	COG1216	Glycosyl transferase, family 2
AFR_RS02855	COG2089	acid synthase
AFR_RS02880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AFR_RS02885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AFR_RS02925	COG0395	ABC-type sugar transport system, permease component
AFR_RS02930	COG1063	alcohol dehydrogenase
AFR_RS02950	COG2814	Major facilitator Superfamily
AFR_RS02970	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AFR_RS02975	COG2119	membrane
AFR_RS03015	COG2213	PTS system mannitol-specific
AFR_RS03020	COG2213	PTS system mannitol-specific
AFR_RS03030	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFR_RS03030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFR_RS03040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFR_RS03050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFR_RS03115	COG2837	iron assimilation
AFR_RS03130	COG3537	Alpha-1,2-mannosidase
AFR_RS03135	COG3285	dna ligase
AFR_RS03135	COG1793	dna ligase
AFR_RS03170	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS03180	COG0667	Aldo Keto reductase
AFR_RS03195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFR_RS03225	COG2390	Transcriptional regulator
AFR_RS03235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AFR_RS03255	COG1609	Transcriptional regulator
AFR_RS03300	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFR_RS03310	COG1129	ABC transporter
AFR_RS03320	COG3347	Dehydrogenase
AFR_RS03320	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS03325	COG1070	Carbohydrate kinase
AFR_RS03330	COG0247	lactate metabolic process
AFR_RS03335	COG1139	Iron-sulfur cluster binding protein
AFR_RS03340	COG1556	Lactate utilization protein
AFR_RS03360	COG1309	transcriptional regulator
AFR_RS03365	COG1131	(ABC) transporter
AFR_RS03370	COG3559	Exporter of polyketide antibiotics
AFR_RS03380	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AFR_RS03395	COG3795	YCII-related domain
AFR_RS03400	COG4941	Belongs to the sigma-70 factor family
AFR_RS03410	COG1082	Xylose isomerase domain protein TIM barrel
AFR_RS03415	COG0673	inositol 2-dehydrogenase activity
AFR_RS03420	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS03425	COG0501	Belongs to the peptidase M48B family
AFR_RS03430	COG0242	peptide deformylase activity
AFR_RS03440	COG2124	cytochrome p450
AFR_RS03460	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AFR_RS03480	COG2197	response regulator
AFR_RS03500	COG0840	transmembrane signaling receptor activity
AFR_RS03510	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AFR_RS03515	COG0009	L-threonylcarbamoyladenylate synthase
AFR_RS03525	COG1846	Transcriptional regulator
AFR_RS03540	COG0431	NADPH-dependent FMN reductase
AFR_RS03565	COG2197	response regulator
AFR_RS03605	COG0673	inositol 2-dehydrogenase activity
AFR_RS03615	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS03690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AFR_RS03770	COG1309	transcriptional regulator
AFR_RS03780	COG0702	epimerase
AFR_RS03820	COG2197	response regulator
AFR_RS03835	COG2382	esterase
AFR_RS03835	COG3693	PFAM glycoside hydrolase, family 10
AFR_RS03835	COG3507	Belongs to the glycosyl hydrolase 43 family
AFR_RS03915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AFR_RS03920	COG0402	S-adenosylhomocysteine deaminase activity
AFR_RS03925	COG1414	Transcriptional regulator
AFR_RS03965	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AFR_RS03970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AFR_RS03980	COG2205	protein histidine kinase activity
AFR_RS03985	COG0745	RESPONSE REGULATOR receiver
AFR_RS04010	COG1193	negative regulation of DNA recombination
AFR_RS04025	COG0745	RESPONSE REGULATOR receiver
AFR_RS04030	COG4251	negative regulation of phosphorylation
AFR_RS04035	COG0784	Response regulator, receiver
AFR_RS04040	COG0483	inositol monophosphate 1-phosphatase activity
AFR_RS04050	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS04065	COG0515	serine threonine protein kinase
AFR_RS04065	COG2815	serine threonine protein kinase
AFR_RS04070	COG0569	domain protein
AFR_RS04075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AFR_RS04115	COG1937	Protein conserved in bacteria
AFR_RS04145	COG0513	Belongs to the DEAD box helicase family
AFR_RS04165	COG0596	Alpha beta hydrolase
AFR_RS04195	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AFR_RS04200	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AFR_RS04210	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AFR_RS04240	COG2045	Belongs to the ComB family
AFR_RS04250	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFR_RS04275	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AFR_RS04290	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFR_RS04295	COG0839	Belongs to the complex I subunit 6 family
AFR_RS04300	COG0713	ATP synthesis coupled electron transport
AFR_RS04310	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFR_RS04315	COG1007	ATP synthesis coupled electron transport
AFR_RS04320	COG0501	Belongs to the peptidase M48B family
AFR_RS04355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS04380	COG4941	Belongs to the sigma-70 factor family
AFR_RS04415	COG0657	acetylesterase activity
AFR_RS04425	COG1666	GTP binding
AFR_RS04445	COG3300	MHYT domain
AFR_RS04445	COG5001	Diguanylate cyclase
AFR_RS04460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AFR_RS04465	COG2030	dehydratase
AFR_RS04480	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AFR_RS04490	COG0081	regulation of translation
AFR_RS04515	COG0085	RNA polymerase activity
AFR_RS04520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AFR_RS04535	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AFR_RS04540	COG0049	tRNA binding
AFR_RS04545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AFR_RS04550	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFR_RS04555	COG0051	transcription antitermination factor activity, RNA binding
AFR_RS04560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AFR_RS04565	COG0088	Forms part of the polypeptide exit tunnel
AFR_RS04570	COG0089	rRNA binding
AFR_RS04575	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AFR_RS04580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AFR_RS04585	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AFR_RS04590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AFR_RS04595	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AFR_RS04600	COG0255	Belongs to the universal ribosomal protein uL29 family
AFR_RS04605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AFR_RS04610	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AFR_RS04615	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AFR_RS04620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AFR_RS04625	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AFR_RS04630	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AFR_RS04635	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AFR_RS04640	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AFR_RS04645	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AFR_RS04650	COG1841	ribosomal large subunit assembly
AFR_RS04655	COG0200	Binds to the 23S rRNA
AFR_RS04665	COG0563	adenylate kinase activity
AFR_RS04685	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AFR_RS04690	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AFR_RS04695	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AFR_RS04700	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AFR_RS04705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AFR_RS04715	COG0203	ribosomal protein L17
AFR_RS04720	COG0101	tRNA pseudouridine synthase activity
AFR_RS04730	COG2813	Specifically methylates the guanine in position
AFR_RS04735	COG0488	(ABC) transporter
AFR_RS04745	COG0352	thiamine-phosphate diphosphorylase activity
AFR_RS04750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFR_RS04750	COG2022	thiamine diphosphate biosynthetic process
AFR_RS04760	COG2022	thiamine diphosphate biosynthetic process
AFR_RS04765	COG0352	thiamine-phosphate diphosphorylase activity
AFR_RS04770	COG0351	phosphomethylpyrimidine kinase
AFR_RS04775	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AFR_RS04800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFR_RS04805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_RS04820	COG2018	Roadblock/LC7 domain
AFR_RS04840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AFR_RS04845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AFR_RS04850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFR_RS04865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AFR_RS04880	COG0736	holo-[acyl-carrier-protein] synthase activity
AFR_RS04890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AFR_RS04900	COG0802	atpase or kinase
AFR_RS04905	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AFR_RS04910	COG0456	acetyltransferase
AFR_RS04910	COG1214	PFAM Peptidase M22, glycoprotease
AFR_RS04920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AFR_RS04930	COG1132	(ABC) transporter
AFR_RS04935	COG1132	(ABC) transporter
AFR_RS04945	COG4214	carbohydrate transport
AFR_RS04960	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AFR_RS04970	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AFR_RS04975	COG0459	protein refolding
AFR_RS04995	COG2197	response regulator
AFR_RS05010	COG0516	GMP reductase activity
AFR_RS05025	COG1404	Belongs to the peptidase S8 family
AFR_RS05035	COG0519	Catalyzes the synthesis of GMP from XMP
AFR_RS05035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AFR_RS05045	COG1051	belongs to the nudix hydrolase family
AFR_RS05055	COG1183	phosphatidylcholine synthase activity
AFR_RS05060	COG0688	phosphatidylethanolamine metabolic process
AFR_RS05080	COG2197	response regulator
AFR_RS05085	COG4166	transmembrane transport
AFR_RS05090	COG0601	transmembrane transport
AFR_RS05095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFR_RS05105	COG4608	Belongs to the ABC transporter superfamily
AFR_RS05115	COG1605	Chorismate mutase
AFR_RS05120	COG4085	toxin activity
AFR_RS05120	COG1525	nuclease
AFR_RS05120	COG0737	Belongs to the 5'-nucleotidase family
AFR_RS05130	COG1196	nuclear chromosome segregation
AFR_RS05130	COG0739	heme binding
AFR_RS05130	COG0741	lytic transglycosylase activity
AFR_RS05135	COG4942	peptidase
AFR_RS05140	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFR_RS05140	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFR_RS05145	COG0045	succinate-CoA ligase (ADP-forming) activity
AFR_RS05170	COG0138	bifunctional purine biosynthesis protein purh
AFR_RS05185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFR_RS05190	COG3540	Alkaline phosphatase
AFR_RS05195	COG0538	isocitrate dehydrogenase activity
AFR_RS05205	COG1349	DNA-binding transcription factor activity
AFR_RS05220	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AFR_RS05265	COG0529	Catalyzes the synthesis of activated sulfate
AFR_RS05285	COG1131	(ABC) transporter
AFR_RS05300	COG0789	Transcriptional regulator
AFR_RS05305	COG4221	oxidoreductase activity
AFR_RS05310	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AFR_RS05340	COG1024	Enoyl-CoA hydratase
AFR_RS05340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AFR_RS05365	COG3177	Filamentation induced by cAMP protein fic
AFR_RS05380	COG0148	phosphopyruvate hydratase activity
AFR_RS05395	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AFR_RS05435	COG0714	Associated with various cellular activities
AFR_RS05450	COG1252	NADH dehydrogenase
AFR_RS05475	COG0183	Belongs to the thiolase family
AFR_RS05480	COG2755	lipolytic protein G-D-S-L family
AFR_RS05515	COG5607	PFAM CHAD domain containing protein
AFR_RS05515	COG3025	triphosphatase activity
AFR_RS05520	COG2326	polyphosphate kinase activity
AFR_RS05525	COG1234	tRNA 3'-trailer cleavage
AFR_RS05540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFR_RS05560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AFR_RS05580	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AFR_RS05585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AFR_RS05595	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AFR_RS05610	COG1331	Highly conserved protein containing a thioredoxin domain
AFR_RS05620	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AFR_RS05630	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AFR_RS05645	COG0515	serine threonine protein kinase
AFR_RS05645	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFR_RS05685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFR_RS05710	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AFR_RS05710	COG0778	Nitroreductase
AFR_RS05715	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AFR_RS05725	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AFR_RS05745	COG0726	polysaccharide deacetylase
AFR_RS05755	COG1012	belongs to the aldehyde dehydrogenase family
AFR_RS05765	COG1012	belongs to the aldehyde dehydrogenase family
AFR_RS05775	COG1515	deoxyribonuclease V activity
AFR_RS05780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFR_RS05785	COG2835	tetraacyldisaccharide 4'-kinase activity
AFR_RS05800	COG1482	cell wall glycoprotein biosynthetic process
AFR_RS05815	COG0672	)-iron permease
AFR_RS05825	COG2837	iron assimilation
AFR_RS05830	COG0745	RESPONSE REGULATOR receiver
AFR_RS05835	COG5002	protein histidine kinase activity
AFR_RS05850	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AFR_RS05855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFR_RS05865	COG0653	protein targeting
AFR_RS05880	COG1522	sequence-specific DNA binding
AFR_RS05900	COG1012	belongs to the aldehyde dehydrogenase family
AFR_RS05910	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AFR_RS05915	COG2884	Cell division ATP-binding protein ftsE
AFR_RS05925	COG1196	nuclear chromosome segregation
AFR_RS05925	COG0741	lytic transglycosylase activity
AFR_RS05925	COG0739	heme binding
AFR_RS05930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AFR_RS05960	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AFR_RS05965	COG1678	Uncharacterized ACR, COG1678
AFR_RS06000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS06005	COG1802	Transcriptional regulator
AFR_RS06015	COG0789	Transcriptional regulator
AFR_RS06050	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AFR_RS06055	COG2165	general secretion pathway protein
AFR_RS06060	COG1459	type II secretion system
AFR_RS06070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AFR_RS06085	COG5640	endopeptidase activity
AFR_RS06105	COG0745	RESPONSE REGULATOR receiver
AFR_RS06110	COG5002	protein histidine kinase activity
AFR_RS06120	COG1846	Transcriptional regulator
AFR_RS06255	COG1953	Uracil, thiamine, allantoin
AFR_RS06270	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS06280	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AFR_RS06300	COG5002	protein histidine kinase activity
AFR_RS06300	COG5001	Diguanylate cyclase
AFR_RS06305	COG0662	Cupin 2, conserved barrel domain protein
AFR_RS06305	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AFR_RS06330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFR_RS06335	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AFR_RS06345	COG1793	dna ligase
AFR_RS06345	COG3285	dna ligase
AFR_RS06355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFR_RS06360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AFR_RS06370	COG0477	Major facilitator Superfamily
AFR_RS06385	COG1335	isochorismatase
AFR_RS06390	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AFR_RS06410	COG0667	Aldo Keto reductase
AFR_RS06435	COG1234	tRNA 3'-trailer cleavage
AFR_RS06440	COG0438	transferase activity, transferring glycosyl groups
AFR_RS06445	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AFR_RS06450	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AFR_RS06480	COG2986	histidine ammonia-lyase
AFR_RS06485	COG1228	amidohydrolase
AFR_RS06500	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AFR_RS06590	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AFR_RS06725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFR_RS06730	COG1177	transmembrane transport
AFR_RS06735	COG1176	ABC-type spermidine putrescine transport system, permease component I
AFR_RS06745	COG3842	ATPase activity
AFR_RS06750	COG1012	belongs to the aldehyde dehydrogenase family
AFR_RS06760	COG0714	Associated with various cellular activities
AFR_RS06780	COG1595	DNA-templated transcription, initiation
AFR_RS06800	COG2197	response regulator
AFR_RS06805	COG4585	Histidine kinase
AFR_RS06815	COG1136	(ABC) transporter
AFR_RS06845	COG1376	ErfK ybiS ycfS ynhG family protein
AFR_RS06850	COG1376	ErfK ybiS ycfS ynhG family protein
AFR_RS06865	COG3629	intracellular signal transduction
AFR_RS06865	COG3629	intracellular signal transduction
AFR_RS06865	COG3903	Transcriptional regulator
AFR_RS06865	COG3903	Transcriptional regulator
AFR_RS06875	COG0784	Response regulator, receiver
AFR_RS06930	COG3647	Membrane
AFR_RS06955	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AFR_RS06960	COG0598	Magnesium transport protein CorA
AFR_RS06995	COG0640	Transcriptional regulator
AFR_RS07040	COG2378	regulation of single-species biofilm formation
AFR_RS07085	COG2706	6-phosphogluconolactonase activity
AFR_RS07110	COG2115	Belongs to the xylose isomerase family
AFR_RS07115	COG1070	Carbohydrate kinase
AFR_RS07120	COG2814	Major facilitator Superfamily
AFR_RS07125	COG0366	Alpha amylase catalytic
AFR_RS07155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AFR_RS07160	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS07230	COG2264	protein methyltransferase activity
AFR_RS07240	COG2197	response regulator
AFR_RS07250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFR_RS07275	COG1846	Transcriptional regulator
AFR_RS07280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFR_RS07295	COG2205	protein histidine kinase activity
AFR_RS07300	COG0745	RESPONSE REGULATOR receiver
AFR_RS07315	COG1136	(ABC) transporter
AFR_RS07320	COG0577	efflux transmembrane transporter activity
AFR_RS07335	COG4941	Belongs to the sigma-70 factor family
AFR_RS07340	COG1595	DNA-templated transcription, initiation
AFR_RS07370	COG0629	single-stranded DNA binding
AFR_RS07375	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AFR_RS07380	COG1492	cobalamin metabolic process
AFR_RS07390	COG0501	Belongs to the peptidase M48B family
AFR_RS07415	COG1793	dna ligase
AFR_RS07430	COG1797	cobyrinic acid a,c-diamide synthase activity
AFR_RS07450	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AFR_RS07455	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AFR_RS07455	COG1648	precorrin-2 dehydrogenase activity
AFR_RS07465	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AFR_RS07510	COG0668	transmembrane transport
AFR_RS07535	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AFR_RS07550	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AFR_RS07570	COG0698	ribose 5-phosphate isomerase
AFR_RS07580	COG4552	Acetyltransferase involved in intracellular survival and related
AFR_RS07590	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS07595	COG2340	Cysteine-rich secretory protein family
AFR_RS07625	COG0544	peptidyl-prolyl cis-trans isomerase activity
AFR_RS07630	COG0740	serine-type endopeptidase activity
AFR_RS07635	COG0740	serine-type endopeptidase activity
AFR_RS07640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AFR_RS07685	COG0525	valine-tRNA ligase activity
AFR_RS07690	COG0285	dihydrofolate synthase activity
AFR_RS07715	COG0105	UTP biosynthetic process
AFR_RS07730	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AFR_RS07740	COG3046	protein related to deoxyribodipyrimidine photolyase
AFR_RS07750	COG0596	Alpha beta hydrolase
AFR_RS07755	COG2172	sigma factor antagonist activity
AFR_RS07755	COG1366	Belongs to the anti-sigma-factor antagonist family
AFR_RS07755	COG2208	phosphoserine phosphatase activity
AFR_RS07775	COG1530	ribonuclease E activity
AFR_RS07785	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AFR_RS07790	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AFR_RS07795	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AFR_RS07800	COG0454	-acetyltransferase
AFR_RS07825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AFR_RS07830	COG0799	negative regulation of ribosome biogenesis
AFR_RS07835	COG0406	alpha-ribazole phosphatase activity
AFR_RS07845	COG1307	EDD domain protein, DegV family
AFR_RS07855	COG2890	protein-(glutamine-N5) methyltransferase activity
AFR_RS07860	COG1596	polysaccharide export
AFR_RS07860	COG1555	photosystem II stabilization
AFR_RS07865	COG0658	competence protein
AFR_RS07865	COG2333	competence protein COMEC
AFR_RS07875	COG3537	Alpha-1,2-mannosidase
AFR_RS07890	COG0268	Binds directly to 16S ribosomal RNA
AFR_RS07910	COG0481	GTPase activity
AFR_RS07930	COG1024	Enoyl-CoA hydratase
AFR_RS07945	COG1420	regulation of RNA biosynthetic process
AFR_RS07950	COG0484	heat shock protein binding
AFR_RS07960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFR_RS07965	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFR_RS07970	COG1120	ATPase activity
AFR_RS07985	COG1132	(ABC) transporter
AFR_RS08000	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AFR_RS08010	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS08020	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AFR_RS08050	COG0537	adenosine 5'-monophosphoramidase activity
AFR_RS08065	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AFR_RS08080	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AFR_RS08100	COG1381	Involved in DNA repair and RecF pathway recombination
AFR_RS08105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AFR_RS08145	COG4172	Belongs to the ABC transporter superfamily
AFR_RS08150	COG4721	ABC-type cobalt transport system, permease component
AFR_RS08155	COG0596	Alpha beta hydrolase
AFR_RS08180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFR_RS08185	COG1121	(ABC) transporter
AFR_RS08190	COG0803	Belongs to the bacterial solute-binding protein 9 family
AFR_RS08190	COG3443	Belongs to the bacterial solute-binding protein 9 family
AFR_RS08210	COG0423	glycine-tRNA ligase activity
AFR_RS08215	COG3608	succinylglutamate desuccinylase aspartoacylase
AFR_RS08215	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AFR_RS08235	COG2018	Roadblock/LC7 domain
AFR_RS08265	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AFR_RS08270	COG0358	DNA primase activity
AFR_RS08295	COG1295	ribonuclease BN
AFR_RS08300	COG1940	carbohydrate kinase activity
AFR_RS08305	COG1129	ABC transporter
AFR_RS08310	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFR_RS08370	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AFR_RS08415	COG0640	Transcriptional regulator
AFR_RS08425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AFR_RS08535	COG1472	Belongs to the glycosyl hydrolase 3 family
AFR_RS08545	COG1012	belongs to the aldehyde dehydrogenase family
AFR_RS08555	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AFR_RS08595	COG2376	Dihydroxyacetone kinase
AFR_RS08600	COG0018	arginyl-trna synthetase
AFR_RS08625	COG0714	Associated with various cellular activities
AFR_RS08665	COG0515	serine threonine protein kinase
AFR_RS08735	COG3973	AAA domain
AFR_RS08760	COG1472	Belongs to the glycosyl hydrolase 3 family
AFR_RS08770	COG0604	alcohol dehydrogenase
AFR_RS08770	COG3321	synthase
AFR_RS08780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AFR_RS08785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFR_RS08825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFR_RS08835	COG2814	Major facilitator Superfamily
AFR_RS08850	COG0840	transmembrane signaling receptor activity
AFR_RS08855	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AFR_RS08860	COG0432	Pfam Uncharacterised protein family UPF0047
AFR_RS08870	COG1131	(ABC) transporter
AFR_RS08905	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS08920	COG2264	protein methyltransferase activity
AFR_RS08960	COG2226	methyltransferase
AFR_RS08985	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AFR_RS09020	COG0730	response to heat
AFR_RS09055	COG4251	negative regulation of phosphorylation
AFR_RS09065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AFR_RS09080	COG0583	DNA-binding transcription factor activity
AFR_RS09090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFR_RS09130	COG0557	exoribonuclease II activity
AFR_RS09140	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AFR_RS09145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFR_RS09145	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AFR_RS09150	COG0174	glutamine synthetase
AFR_RS09155	COG3766	membrane
AFR_RS09165	COG0456	acetyltransferase
AFR_RS09165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFR_RS09175	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AFR_RS09235	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AFR_RS09275	COG3629	intracellular signal transduction
AFR_RS09275	COG3903	Transcriptional regulator
AFR_RS09280	COG1324	tolerance protein
AFR_RS09320	COG4941	Belongs to the sigma-70 factor family
AFR_RS09340	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AFR_RS09345	COG0017	Asparaginyl-tRNA synthetase
AFR_RS09355	COG0321	lipoyl(octanoyl) transferase activity
AFR_RS09370	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFR_RS09375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFR_RS09385	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AFR_RS09390	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AFR_RS09395	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AFR_RS09400	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AFR_RS09410	COG1994	Peptidase M50
AFR_RS09415	COG0667	Aldo Keto reductase
AFR_RS09435	COG4555	ABC transporter
AFR_RS09445	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AFR_RS09465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AFR_RS09470	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AFR_RS09475	COG1929	Belongs to the glycerate kinase type-1 family
AFR_RS09485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFR_RS09495	COG0425	Belongs to the sulfur carrier protein TusA family
AFR_RS09500	COG1104	cysteine desulfurase activity
AFR_RS09505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AFR_RS09520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFR_RS09540	COG2010	Cytochrome c
AFR_RS09550	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AFR_RS09570	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AFR_RS09575	COG2816	NAD+ diphosphatase activity
AFR_RS09580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFR_RS09600	COG0501	Belongs to the peptidase M48B family
AFR_RS09605	COG0438	transferase activity, transferring glycosyl groups
AFR_RS09610	COG1132	(ABC) transporter
AFR_RS09630	COG1131	(ABC) transporter
AFR_RS09650	COG2197	response regulator
AFR_RS09665	COG1940	carbohydrate kinase activity
AFR_RS09675	COG2072	flavoprotein involved in K transport
AFR_RS09725	COG1309	transcriptional regulator
AFR_RS09740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AFR_RS09750	COG0386	Belongs to the glutathione peroxidase family
AFR_RS09760	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AFR_RS09775	COG3321	synthase
AFR_RS09775	COG0604	alcohol dehydrogenase
AFR_RS09795	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AFR_RS09800	COG2815	serine threonine protein kinase
AFR_RS09800	COG0515	serine threonine protein kinase
AFR_RS09830	COG0142	geranyltranstransferase activity
AFR_RS09900	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AFR_RS09905	COG1053	succinate dehydrogenase
AFR_RS09915	COG0583	DNA-binding transcription factor activity
AFR_RS09925	COG0702	epimerase
AFR_RS09930	COG1846	Transcriptional regulator
AFR_RS10005	COG1404	Belongs to the peptidase S8 family
AFR_RS10020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AFR_RS10040	COG0714	Associated with various cellular activities
AFR_RS10045	COG0495	leucyl-tRNA aminoacylation
AFR_RS10050	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AFR_RS10060	COG3442	glutamine amidotransferase
AFR_RS10065	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AFR_RS10075	COG2001	Belongs to the MraZ family
AFR_RS10080	COG0275	rRNA processing
AFR_RS10090	COG0768	penicillin binding
AFR_RS10095	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AFR_RS10105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFR_RS10115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AFR_RS10120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AFR_RS10125	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AFR_RS10130	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AFR_RS10135	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AFR_RS10140	COG1799	cell septum assembly
AFR_RS10170	COG3263	regulation of cellular component size
AFR_RS10180	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AFR_RS10200	COG0587	DNA-directed DNA polymerase activity
AFR_RS10215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AFR_RS10220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFR_RS10225	COG0131	Imidazoleglycerol-phosphate dehydratase
AFR_RS10230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AFR_RS10240	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AFR_RS10250	COG0583	DNA-binding transcription factor activity
AFR_RS10260	COG0107	imidazoleglycerol-phosphate synthase activity
AFR_RS10270	COG2364	Membrane
AFR_RS10275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFR_RS10295	COG1595	DNA-templated transcription, initiation
AFR_RS10300	COG1022	Amp-dependent synthetase and ligase
AFR_RS10315	COG2226	methyltransferase
AFR_RS10320	COG2205	protein histidine kinase activity
AFR_RS10325	COG0745	RESPONSE REGULATOR receiver
AFR_RS10350	COG1132	(ABC) transporter
AFR_RS10355	COG1132	(ABC) transporter
AFR_RS10360	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AFR_RS10380	COG1131	(ABC) transporter
AFR_RS10390	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AFR_RS10405	COG0134	indole-3-glycerol-phosphate synthase activity
AFR_RS10410	COG0133	tryptophan synthase activity
AFR_RS10415	COG0159	tryptophan synthase activity
AFR_RS10420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AFR_RS10435	COG0067	glutamate synthase
AFR_RS10435	COG0070	glutamate synthase
AFR_RS10435	COG0069	glutamate synthase activity
AFR_RS10515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFR_RS10520	COG0765	amino acid transport
AFR_RS10525	COG1126	abc transporter atp-binding protein
AFR_RS10550	COG2226	methyltransferase
AFR_RS10555	COG0539	negative regulation of cytoplasmic translation
AFR_RS10560	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AFR_RS10560	COG0237	dephospho-CoA kinase activity
AFR_RS10580	COG2329	Antibiotic biosynthesis monooxygenase
AFR_RS10590	COG1217	gtp-binding protein TYPA
AFR_RS10600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AFR_RS10605	COG0740	serine-type endopeptidase activity
AFR_RS10610	COG1335	isochorismatase
AFR_RS10615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFR_RS10625	COG1162	GTPase activity
AFR_RS10635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AFR_RS10645	COG0322	excinuclease ABC activity
AFR_RS10650	COG1660	Displays ATPase and GTPase activities
AFR_RS10660	COG1481	regulation of sporulation
AFR_RS10665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AFR_RS10670	COG0126	phosphoglycerate kinase activity
AFR_RS10675	COG0149	triose-phosphate isomerase activity
AFR_RS10680	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AFR_RS10690	COG0456	acetyltransferase
AFR_RS10700	COG1595	DNA-templated transcription, initiation
AFR_RS10715	COG0363	glucosamine-6-phosphate deaminase activity
AFR_RS10735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AFR_RS10745	COG0109	protoheme IX farnesyltransferase activity
AFR_RS10770	COG0719	Fe-S assembly protein
AFR_RS10775	COG2146	nitrite reductase [NAD(P)H] activity
AFR_RS10780	COG0396	ATPase activity
AFR_RS10785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AFR_RS10790	COG0822	iron-sulfur transferase activity
AFR_RS10795	COG2151	metal-sulfur cluster biosynthetic enzyme
AFR_RS10800	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS10805	COG1063	alcohol dehydrogenase
AFR_RS10810	COG0179	Fumarylacetoacetate (FAA) hydrolase
AFR_RS10815	COG3386	PFAM SMP-30 Gluconolaconase
AFR_RS10820	COG1414	Transcriptional regulator
AFR_RS10825	COG0129	dihydroxy-acid dehydratase activity
AFR_RS10875	COG2321	neutral zinc metallopeptidase
AFR_RS10880	COG0488	(ABC) transporter
AFR_RS10890	COG1024	Enoyl-CoA hydratase
AFR_RS10895	COG1132	(ABC) transporter
AFR_RS10910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFR_RS10975	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS10985	COG3220	belongs to the UPF0276 family
AFR_RS10995	COG1309	transcriptional regulator
AFR_RS11025	COG0745	RESPONSE REGULATOR receiver
AFR_RS11030	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AFR_RS11060	COG1309	transcriptional regulator
AFR_RS11070	COG0006	proline dipeptidase activity
AFR_RS11105	COG0714	Associated with various cellular activities
AFR_RS11115	COG2304	oxidoreductase activity
AFR_RS11130	COG2197	response regulator
AFR_RS11135	COG4585	Histidine kinase
AFR_RS11155	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AFR_RS11180	COG0840	transmembrane signaling receptor activity
AFR_RS11190	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS11255	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AFR_RS11270	COG1365	unkown
AFR_RS11275	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AFR_RS11285	COG2182	Extracellular solute-binding protein
AFR_RS11290	COG1175	transmembrane transport
AFR_RS11295	COG0395	ABC-type sugar transport system, permease component
AFR_RS11300	COG1653	transport
AFR_RS11305	COG1175	transmembrane transport
AFR_RS11310	COG0395	ABC-type sugar transport system, permease component
AFR_RS11320	COG2223	nitrite transmembrane transporter activity
AFR_RS11325	COG1472	Belongs to the glycosyl hydrolase 3 family
AFR_RS11335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AFR_RS11335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AFR_RS11345	COG1960	acyl-CoA dehydrogenase activity
AFR_RS11365	COG2018	Roadblock/LC7 domain
AFR_RS11370	COG5002	protein histidine kinase activity
AFR_RS11375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AFR_RS11400	COG4585	Histidine kinase
AFR_RS11405	COG2197	response regulator
AFR_RS11435	COG1846	Transcriptional regulator
AFR_RS11440	COG0300	oxidoreductase activity
AFR_RS11475	COG0483	inositol monophosphate 1-phosphatase activity
AFR_RS11540	COG0667	Aldo Keto reductase
AFR_RS11545	COG2205	protein histidine kinase activity
AFR_RS11550	COG0745	RESPONSE REGULATOR receiver
AFR_RS11585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AFR_RS11590	COG1609	Transcriptional regulator
AFR_RS11595	COG0366	Alpha amylase catalytic
AFR_RS11615	COG1733	regulation of RNA biosynthetic process
AFR_RS11620	COG0667	Aldo Keto reductase
AFR_RS11630	COG2353	YceI-like domain
AFR_RS11640	COG1136	(ABC) transporter
AFR_RS11640	COG0577	efflux transmembrane transporter activity
AFR_RS11650	COG0436	Aminotransferase
AFR_RS11670	COG0745	RESPONSE REGULATOR receiver
AFR_RS11690	COG3903	Transcriptional regulator
AFR_RS11690	COG3629	intracellular signal transduction
AFR_RS11695	COG2770	Histidine kinase
AFR_RS11695	COG2208	phosphoserine phosphatase activity
AFR_RS11705	COG2197	response regulator
AFR_RS11720	COG1086	Polysaccharide biosynthesis protein
AFR_RS11730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AFR_RS11740	COG3795	YCII-related domain
AFR_RS11755	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS11760	COG0583	DNA-binding transcription factor activity
AFR_RS11805	COG0489	protein tyrosine kinase activity
AFR_RS11805	COG3206	protein involved in exopolysaccharide biosynthesis
AFR_RS11815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AFR_RS11875	COG0671	phosphoesterase, PA-phosphatase related
AFR_RS11905	COG0456	acetyltransferase
AFR_RS11905	COG1846	Transcriptional regulator
AFR_RS11945	COG0514	ATP-dependent DNA helicase (RecQ)
AFR_RS11960	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AFR_RS11960	COG1672	PFAM Archaeal ATPase
AFR_RS12000	COG0596	Alpha beta hydrolase
AFR_RS12020	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS12025	COG0583	DNA-binding transcription factor activity
AFR_RS12045	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS12065	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS12070	COG1309	transcriptional regulator
AFR_RS12105	COG0596	Alpha beta hydrolase
AFR_RS12125	COG0840	transmembrane signaling receptor activity
AFR_RS12150	COG0714	Associated with various cellular activities
AFR_RS12285	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS12345	COG0667	Aldo Keto reductase
AFR_RS12375	COG2197	response regulator
AFR_RS12390	COG1073	alpha beta
AFR_RS12405	COG1266	CAAX protease self-immunity
AFR_RS12420	COG4566	intracellular signal transduction
AFR_RS12450	COG0596	Alpha beta hydrolase
AFR_RS12455	COG2197	response regulator
AFR_RS12475	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AFR_RS12480	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AFR_RS12530	COG4585	Histidine kinase
AFR_RS12535	COG2197	response regulator
AFR_RS12610	COG5002	protein histidine kinase activity
AFR_RS12635	COG2197	response regulator
AFR_RS12660	COG1131	(ABC) transporter
AFR_RS12665	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS12670	COG1012	belongs to the aldehyde dehydrogenase family
AFR_RS12690	COG0395	ABC-type sugar transport system, permease component
AFR_RS12710	COG0604	alcohol dehydrogenase
AFR_RS12710	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS12710	COG3321	synthase
AFR_RS12720	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AFR_RS12725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFR_RS12775	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AFR_RS12790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFR_RS12795	COG2211	Major facilitator Superfamily
AFR_RS12800	COG1802	Transcriptional regulator
AFR_RS12805	COG0473	3-isopropylmalate dehydrogenase activity
AFR_RS12835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AFR_RS12870	COG1091	dTDP-4-dehydrorhamnose reductase activity
AFR_RS12875	COG1595	DNA-templated transcription, initiation
AFR_RS12885	COG1131	(ABC) transporter
AFR_RS12900	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS12930	COG3940	Belongs to the glycosyl hydrolase 43 family
AFR_RS12945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFR_RS12990	COG0300	oxidoreductase activity
AFR_RS13005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFR_RS13010	COG0477	Major facilitator Superfamily
AFR_RS13035	COG2197	response regulator
AFR_RS13040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFR_RS13080	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS13085	COG0667	Aldo Keto reductase
AFR_RS13105	COG1309	transcriptional regulator
AFR_RS13115	COG0702	epimerase
AFR_RS13125	COG0300	oxidoreductase activity
AFR_RS13150	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS13165	COG4211	Belongs to the binding-protein-dependent transport system permease family
AFR_RS13170	COG1129	ABC transporter
AFR_RS13180	COG0145	ligase activity
AFR_RS13205	COG0477	Major facilitator Superfamily
AFR_RS13225	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFR_RS13225	COG1024	Enoyl-CoA hydratase
AFR_RS13245	COG0745	RESPONSE REGULATOR receiver
AFR_RS13250	COG2205	protein histidine kinase activity
AFR_RS13265	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AFR_RS13290	COG1175	transmembrane transport
AFR_RS13295	COG0395	ABC-type sugar transport system, permease component
AFR_RS13360	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AFR_RS13380	COG0667	Aldo Keto reductase
AFR_RS13395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS13415	COG0745	RESPONSE REGULATOR receiver
AFR_RS13420	COG2205	protein histidine kinase activity
AFR_RS13430	COG0577	efflux transmembrane transporter activity
AFR_RS13430	COG1136	(ABC) transporter
AFR_RS13435	COG4221	oxidoreductase activity
AFR_RS13460	COG4221	oxidoreductase activity
AFR_RS13465	COG0583	DNA-binding transcription factor activity
AFR_RS13470	COG1309	transcriptional regulator
AFR_RS13480	COG0477	Major facilitator Superfamily
AFR_RS13495	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS13535	COG2018	Roadblock/LC7 domain
AFR_RS13545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFR_RS13565	COG0667	Aldo Keto reductase
AFR_RS13570	COG0667	Aldo Keto reductase
AFR_RS13575	COG4221	oxidoreductase activity
AFR_RS13585	COG0583	DNA-binding transcription factor activity
AFR_RS13595	COG2814	Major facilitator Superfamily
AFR_RS13630	COG4221	oxidoreductase activity
AFR_RS13685	COG1309	transcriptional regulator
AFR_RS13695	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS13720	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS13745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS13755	COG1309	transcriptional regulator
AFR_RS13830	COG4585	Histidine kinase
AFR_RS13845	COG3321	synthase
AFR_RS13845	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS13845	COG0604	alcohol dehydrogenase
AFR_RS13855	COG1215	transferase activity, transferring glycosyl groups
AFR_RS13875	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFR_RS13905	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AFR_RS13915	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AFR_RS13980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AFR_RS14015	COG2409	Drug exporters of the RND superfamily
AFR_RS14030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFR_RS14040	COG1404	Belongs to the peptidase S8 family
AFR_RS14045	COG1309	transcriptional regulator
AFR_RS14065	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS14070	COG2340	Cysteine-rich secretory protein family
AFR_RS14085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFR_RS14140	COG2837	iron assimilation
AFR_RS14150	COG0477	Major facilitator Superfamily
AFR_RS14205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AFR_RS14220	COG2208	phosphoserine phosphatase activity
AFR_RS14220	COG2770	Histidine kinase
AFR_RS14245	COG2860	membrane
AFR_RS14260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AFR_RS14265	COG0028	Belongs to the TPP enzyme family
AFR_RS14285	COG0251	oxidation-reduction process
AFR_RS14305	COG1063	alcohol dehydrogenase
AFR_RS14360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AFR_RS14365	COG2409	Drug exporters of the RND superfamily
AFR_RS14370	COG1063	alcohol dehydrogenase
AFR_RS14375	COG0701	Predicted permease
AFR_RS14380	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AFR_RS14390	COG1131	(ABC) transporter
AFR_RS14415	COG2847	Copper chaperone PCu(A)C
AFR_RS14425	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AFR_RS14435	COG2814	Major facilitator Superfamily
AFR_RS14445	COG1175	transmembrane transport
AFR_RS14450	COG0395	ABC-type sugar transport system, permease component
AFR_RS14475	COG1309	transcriptional regulator
AFR_RS14485	COG1309	transcriptional regulator
AFR_RS14625	COG1278	Cold shock
AFR_RS14635	COG4977	sequence-specific DNA binding
AFR_RS14655	COG0596	Alpha beta hydrolase
AFR_RS14660	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AFR_RS14670	COG1917	Cupin 2, conserved barrel domain protein
AFR_RS14670	COG4977	sequence-specific DNA binding
AFR_RS14675	COG1960	acyl-CoA dehydrogenase activity
AFR_RS14680	COG4608	Belongs to the ABC transporter superfamily
AFR_RS14690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFR_RS14695	COG0601	transmembrane transport
AFR_RS14700	COG0747	negative chemotaxis
AFR_RS14705	COG1022	Amp-dependent synthetase and ligase
AFR_RS14735	COG4733	cellulase activity
AFR_RS14755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFR_RS14770	COG1309	transcriptional regulator
AFR_RS14775	COG0596	Alpha beta hydrolase
AFR_RS14800	COG2132	Multicopper oxidase
AFR_RS14815	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS14850	COG0640	Transcriptional regulator
AFR_RS14860	COG3693	PFAM glycoside hydrolase, family 10
AFR_RS14875	COG0395	ABC-type sugar transport system, permease component
AFR_RS14880	COG2409	Drug exporters of the RND superfamily
AFR_RS14895	COG4585	Histidine kinase
AFR_RS14900	COG2197	response regulator
AFR_RS14905	COG3291	Pkd domain containing protein
AFR_RS14910	COG1309	transcriptional regulator
AFR_RS14945	COG0596	Alpha beta hydrolase
AFR_RS14950	COG3629	intracellular signal transduction
AFR_RS14970	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS14980	COG4733	cellulase activity
AFR_RS14980	COG5297	Belongs to the glycosyl hydrolase family 6
AFR_RS14985	COG3693	PFAM glycoside hydrolase, family 10
AFR_RS15020	COG0515	serine threonine protein kinase
AFR_RS15025	COG1940	carbohydrate kinase activity
AFR_RS15030	COG3345	alpha-galactosidase
AFR_RS15040	COG0395	ABC-type sugar transport system, permease component
AFR_RS15045	COG1175	transmembrane transport
AFR_RS15110	COG0596	Alpha beta hydrolase
AFR_RS15130	COG2205	protein histidine kinase activity
AFR_RS15135	COG0745	RESPONSE REGULATOR receiver
AFR_RS15140	COG1131	(ABC) transporter
AFR_RS15170	COG4941	Belongs to the sigma-70 factor family
AFR_RS15185	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS15190	COG0667	Aldo Keto reductase
AFR_RS15195	COG1064	alcohol dehydrogenase
AFR_RS15205	COG1733	regulation of RNA biosynthetic process
AFR_RS15210	COG1309	transcriptional regulator
AFR_RS15215	COG1131	(ABC) transporter
AFR_RS15230	COG0583	DNA-binding transcription factor activity
AFR_RS15250	COG2354	Protein conserved in bacteria
AFR_RS15290	COG3511	phospholipase C
AFR_RS15295	COG1533	DNA photolyase activity
AFR_RS15330	COG2207	Transcriptional regulator
AFR_RS15355	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AFR_RS15365	COG1733	regulation of RNA biosynthetic process
AFR_RS15375	COG4124	Belongs to the glycosyl hydrolase 26 family
AFR_RS15385	COG3833	ABC-type maltose transport systems, permease component
AFR_RS15400	COG1609	Transcriptional regulator
AFR_RS15430	COG1063	alcohol dehydrogenase
AFR_RS15435	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AFR_RS15440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AFR_RS15455	COG2814	Major facilitator Superfamily
AFR_RS15500	COG1073	alpha beta
AFR_RS15510	COG2205	protein histidine kinase activity
AFR_RS15515	COG0745	RESPONSE REGULATOR receiver
AFR_RS15535	COG0300	oxidoreductase activity
AFR_RS15540	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS15575	COG3537	Alpha-1,2-mannosidase
AFR_RS15595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS15675	COG3507	Belongs to the glycosyl hydrolase 43 family
AFR_RS15685	COG2207	Transcriptional regulator
AFR_RS15685	COG3708	Transcriptional regulator
AFR_RS15730	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS15765	COG3842	ATPase activity
AFR_RS15770	COG1177	transmembrane transport
AFR_RS15785	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS15790	COG0028	Belongs to the TPP enzyme family
AFR_RS15795	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AFR_RS15815	COG2072	flavoprotein involved in K transport
AFR_RS15850	COG2814	Major facilitator Superfamily
AFR_RS15875	COG2226	methyltransferase
AFR_RS15885	COG0596	Alpha beta hydrolase
AFR_RS15890	COG2356	endonuclease I
AFR_RS15895	COG0010	Belongs to the arginase family
AFR_RS15925	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFR_RS15930	COG0667	Aldo Keto reductase
AFR_RS15935	COG1309	transcriptional regulator
AFR_RS15940	COG3181	Tripartite tricarboxylate transporter family receptor
AFR_RS15960	COG3290	protein histidine kinase activity
AFR_RS15970	COG3629	intracellular signal transduction
AFR_RS15970	COG3903	Transcriptional regulator
AFR_RS15980	COG0673	inositol 2-dehydrogenase activity
AFR_RS15985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AFR_RS16025	COG0019	diaminopimelate decarboxylase activity
AFR_RS16030	COG0318	PFAM AMP-dependent synthetase and ligase
AFR_RS16060	COG1216	Glycosyl transferase, family 2
AFR_RS16080	COG0438	transferase activity, transferring glycosyl groups
AFR_RS16100	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AFR_RS16155	COG1309	transcriptional regulator
AFR_RS16160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFR_RS16210	COG1522	sequence-specific DNA binding
AFR_RS16225	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AFR_RS16235	COG2197	response regulator
AFR_RS16240	COG4585	Histidine kinase
AFR_RS16245	COG2409	Drug exporters of the RND superfamily
AFR_RS16255	COG0584	glycerophosphoryl diester phosphodiesterase
AFR_RS16270	COG2815	serine threonine protein kinase
AFR_RS16270	COG0515	serine threonine protein kinase
AFR_RS16295	COG0667	Aldo Keto reductase
AFR_RS16305	COG4213	ABC transporter substrate-binding protein
AFR_RS16315	COG4214	carbohydrate transport
AFR_RS16320	COG1940	carbohydrate kinase activity
AFR_RS16345	COG2197	response regulator
AFR_RS16365	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AFR_RS16380	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AFR_RS16385	COG0714	Associated with various cellular activities
AFR_RS16430	COG0768	penicillin binding
AFR_RS16445	COG4221	oxidoreductase activity
AFR_RS16455	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AFR_RS16460	COG2376	Dihydroxyacetone kinase
AFR_RS16465	COG1461	Dihydroxyacetone kinase
AFR_RS16470	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFR_RS16470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFR_RS16530	COG3940	Belongs to the glycosyl hydrolase 43 family
AFR_RS16545	COG0531	amino acid
AFR_RS16560	COG1309	transcriptional regulator
AFR_RS16590	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AFR_RS16605	COG1215	transferase activity, transferring glycosyl groups
AFR_RS16625	COG2986	histidine ammonia-lyase
AFR_RS16655	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS16660	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AFR_RS16660	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AFR_RS16665	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AFR_RS16670	COG0297	glycogen (starch) synthase activity
AFR_RS16680	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AFR_RS16690	COG2192	nodulation
AFR_RS16695	COG1012	belongs to the aldehyde dehydrogenase family
AFR_RS16715	COG0563	adenylate kinase activity
AFR_RS16720	COG1120	ATPase activity
AFR_RS16805	COG0372	Belongs to the citrate synthase family
AFR_RS16850	COG0574	Belongs to the PEP-utilizing enzyme family
AFR_RS16850	COG3848	Pyruvate phosphate dikinase
AFR_RS16860	COG0577	efflux transmembrane transporter activity
AFR_RS16865	COG1136	(ABC) transporter
AFR_RS16865	COG0577	efflux transmembrane transporter activity
AFR_RS16890	COG1595	DNA-templated transcription, initiation
AFR_RS16895	COG0584	glycerophosphoryl diester phosphodiesterase
AFR_RS16910	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AFR_RS16915	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS16920	COG4585	Histidine kinase
AFR_RS16925	COG2197	response regulator
AFR_RS16935	COG0534	Mate efflux family protein
AFR_RS16950	COG1609	Transcriptional regulator
AFR_RS16965	COG0673	inositol 2-dehydrogenase activity
AFR_RS16980	COG0395	ABC-type sugar transport system, permease component
AFR_RS16985	COG1175	transmembrane transport
AFR_RS16995	COG1904	glucuronate isomerase
AFR_RS17000	COG0246	Mannitol dehydrogenase
AFR_RS17005	COG4106	trans-aconitate 2-methyltransferase activity
AFR_RS17045	COG1012	belongs to the aldehyde dehydrogenase family
AFR_RS17060	COG0022	dehydrogenase e1 component
AFR_RS17065	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFR_RS17100	COG1404	Belongs to the peptidase S8 family
AFR_RS17100	COG4412	M6 family metalloprotease domain protein
AFR_RS17130	COG3300	MHYT domain
AFR_RS17130	COG5001	Diguanylate cyclase
AFR_RS17135	COG0156	8-amino-7-oxononanoate synthase activity
AFR_RS17150	COG0515	serine threonine protein kinase
AFR_RS17150	COG2815	serine threonine protein kinase
AFR_RS17175	COG1595	DNA-templated transcription, initiation
AFR_RS17210	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AFR_RS17220	COG3300	MHYT domain
AFR_RS17220	COG5001	Diguanylate cyclase
AFR_RS17225	COG0156	8-amino-7-oxononanoate synthase activity
AFR_RS17230	COG2814	Major facilitator Superfamily
AFR_RS17240	COG3345	alpha-galactosidase
AFR_RS17250	COG0586	Pfam SNARE associated Golgi protein
AFR_RS17265	COG1252	NADH dehydrogenase
AFR_RS17300	COG1072	(Pantothenic acid kinase))
AFR_RS17305	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS17345	COG3655	Transcriptional regulator
AFR_RS17355	COG0431	NADPH-dependent FMN reductase
AFR_RS17360	COG0784	Response regulator, receiver
AFR_RS17425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AFR_RS17455	COG0577	efflux transmembrane transporter activity
AFR_RS17455	COG1136	(ABC) transporter
AFR_RS17470	COG0745	RESPONSE REGULATOR receiver
AFR_RS17475	COG2205	protein histidine kinase activity
AFR_RS17480	COG3300	MHYT domain
AFR_RS17480	COG5001	Diguanylate cyclase
AFR_RS17490	COG0463	Glycosyl transferase, family 2
AFR_RS17495	COG0673	inositol 2-dehydrogenase activity
AFR_RS17515	COG3300	MHYT domain
AFR_RS17515	COG5001	Diguanylate cyclase
AFR_RS17670	COG0515	serine threonine protein kinase
AFR_RS17705	COG4677	pectinesterase activity
AFR_RS17710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFR_RS17715	COG1802	Transcriptional regulator
AFR_RS17720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AFR_RS17735	COG1335	isochorismatase
AFR_RS17740	COG1472	Belongs to the glycosyl hydrolase 3 family
AFR_RS17745	COG1940	carbohydrate kinase activity
AFR_RS17755	COG4209	transmembrane transport
AFR_RS17760	COG0395	ABC-type sugar transport system, permease component
AFR_RS17785	COG3693	PFAM glycoside hydrolase, family 10
AFR_RS17790	COG2197	response regulator
AFR_RS17795	COG4585	Histidine kinase
AFR_RS17830	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AFR_RS17840	COG3191	aminopeptidase activity
AFR_RS17895	COG0784	Response regulator, receiver
AFR_RS17900	COG1619	proteins homologs of microcin C7 resistance protein MccF
AFR_RS17930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFR_RS17955	COG2072	flavoprotein involved in K transport
AFR_RS17990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AFR_RS18000	COG2226	methyltransferase
AFR_RS18010	COG0583	DNA-binding transcription factor activity
AFR_RS18015	COG3940	Belongs to the glycosyl hydrolase 43 family
AFR_RS18025	COG3866	Pectate lyase
AFR_RS18055	COG0438	transferase activity, transferring glycosyl groups
AFR_RS18065	COG0277	FAD linked oxidase domain protein
AFR_RS18065	COG0247	lactate metabolic process
AFR_RS18070	COG1733	regulation of RNA biosynthetic process
AFR_RS18075	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AFR_RS18090	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS18100	COG0438	transferase activity, transferring glycosyl groups
AFR_RS18105	COG0438	transferase activity, transferring glycosyl groups
AFR_RS18110	COG0438	transferase activity, transferring glycosyl groups
AFR_RS18125	COG1472	Belongs to the glycosyl hydrolase 3 family
AFR_RS18135	COG1175	transmembrane transport
AFR_RS18145	COG1609	Transcriptional regulator
AFR_RS18180	COG3509	depolymerase
AFR_RS18190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AFR_RS18195	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AFR_RS18210	COG0667	Aldo Keto reductase
AFR_RS18215	COG3226	Transcriptional regulator
AFR_RS18245	COG0667	Aldo Keto reductase
AFR_RS18265	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS18285	COG3300	MHYT domain
AFR_RS18285	COG5001	Diguanylate cyclase
AFR_RS18330	COG2936	dipeptidyl-peptidase activity
AFR_RS18360	COG3842	ATPase activity
AFR_RS18365	COG1177	transmembrane transport
AFR_RS18395	COG3268	Saccharopine dehydrogenase
AFR_RS18400	COG3706	GGDEF domain
AFR_RS18405	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS18425	COG1609	Transcriptional regulator
AFR_RS18430	COG0673	inositol 2-dehydrogenase activity
AFR_RS18450	COG1609	Transcriptional regulator
AFR_RS18465	COG1079	Belongs to the binding-protein-dependent transport system permease family
AFR_RS18525	COG1132	(ABC) transporter
AFR_RS18530	COG0010	Belongs to the arginase family
AFR_RS18570	COG4638	Rieske (2fe-2S)
AFR_RS18575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFR_RS18595	COG4175	Glycine betaine
AFR_RS18595	COG0517	IMP dehydrogenase activity
AFR_RS18605	COG0586	Pfam SNARE associated Golgi protein
AFR_RS18665	COG0318	PFAM AMP-dependent synthetase and ligase
AFR_RS18670	COG1960	acyl-CoA dehydrogenase activity
AFR_RS18685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AFR_RS18695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AFR_RS18710	COG2409	Drug exporters of the RND superfamily
AFR_RS18715	COG2423	ornithine cyclodeaminase activity
AFR_RS18720	COG2197	response regulator
AFR_RS18725	COG4585	Histidine kinase
AFR_RS18735	COG0477	Major facilitator Superfamily
AFR_RS18740	COG1309	transcriptional regulator
AFR_RS18755	COG2814	Major facilitator Superfamily
AFR_RS18765	COG3706	GGDEF domain
AFR_RS18785	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AFR_RS18795	COG3384	dioxygenase
AFR_RS18820	COG0243	molybdopterin cofactor binding
AFR_RS18830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFR_RS18835	COG2146	nitrite reductase [NAD(P)H] activity
AFR_RS18840	COG2223	nitrite transmembrane transporter activity
AFR_RS18900	COG4335	DNA alkylation repair
AFR_RS18905	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AFR_RS18940	COG2084	Dehydrogenase
AFR_RS18955	COG0803	Belongs to the bacterial solute-binding protein 9 family
AFR_RS18960	COG1121	(ABC) transporter
AFR_RS19015	COG4948	Mandelate Racemase Muconate Lactonizing
AFR_RS19080	COG5297	Belongs to the glycosyl hydrolase family 6
AFR_RS19080	COG4733	cellulase activity
AFR_RS19090	COG1609	Transcriptional regulator
AFR_RS19095	COG1879	ABC-type sugar transport system periplasmic component
AFR_RS19105	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFR_RS19110	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFR_RS19125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS19135	COG0477	Major facilitator Superfamily
AFR_RS19140	COG1309	transcriptional regulator
AFR_RS19145	COG2318	DinB family
AFR_RS19150	COG0254	rRNA binding
AFR_RS19160	COG3864	Putative metallopeptidase domain
AFR_RS19190	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AFR_RS19195	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AFR_RS19200	COG2080	2 iron, 2 sulfur cluster binding
AFR_RS19250	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AFR_RS19255	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AFR_RS19275	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AFR_RS19295	COG5001	Diguanylate cyclase
AFR_RS19300	COG0275	rRNA processing
AFR_RS19310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS19315	COG2207	Transcriptional regulator
AFR_RS19320	COG0667	Aldo Keto reductase
AFR_RS19340	COG5001	Diguanylate cyclase
AFR_RS19340	COG3300	MHYT domain
AFR_RS19405	COG2205	protein histidine kinase activity
AFR_RS19410	COG0745	RESPONSE REGULATOR receiver
AFR_RS19430	COG1414	Transcriptional regulator
AFR_RS19435	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AFR_RS19440	COG0596	Alpha beta hydrolase
AFR_RS19445	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AFR_RS19450	COG3485	protocatechuate 3,4-dioxygenase
AFR_RS19455	COG3485	protocatechuate 3,4-dioxygenase
AFR_RS19460	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AFR_RS19465	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AFR_RS19480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_RS19485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_RS19495	COG1012	belongs to the aldehyde dehydrogenase family
AFR_RS19500	COG2267	carboxylic ester hydrolase activity
AFR_RS19510	COG0395	ABC-type sugar transport system, permease component
AFR_RS19515	COG1175	transmembrane transport
AFR_RS19520	COG2182	Extracellular solute-binding protein
AFR_RS19525	COG3250	beta-galactosidase activity
AFR_RS19570	COG1175	transmembrane transport
AFR_RS19575	COG3833	ABC-type maltose transport systems, permease component
AFR_RS19580	COG0604	alcohol dehydrogenase
AFR_RS19595	COG3226	Transcriptional regulator
AFR_RS19605	COG0748	coenzyme F420 binding
AFR_RS19610	COG2814	Major facilitator Superfamily
AFR_RS19615	COG1846	Transcriptional regulator
AFR_RS19620	COG0667	Aldo Keto reductase
AFR_RS19625	COG3104	oligopeptide transport
AFR_RS19630	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AFR_RS19630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AFR_RS19635	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AFR_RS19645	COG0745	RESPONSE REGULATOR receiver
AFR_RS19650	COG2205	protein histidine kinase activity
AFR_RS19665	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AFR_RS19670	COG1691	(AIR) carboxylase
AFR_RS19675	COG1606	tRNA processing
AFR_RS19680	COG1609	Transcriptional regulator
AFR_RS19695	COG0183	Belongs to the thiolase family
AFR_RS19700	COG1122	ATPase activity
AFR_RS19715	COG0310	cobalt ion transport
AFR_RS19740	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AFR_RS19755	COG3401	FG-GAP repeat protein
AFR_RS19765	COG3226	Transcriptional regulator
AFR_RS19770	COG0247	lactate metabolic process
AFR_RS19775	COG0277	FAD linked oxidase domain protein
AFR_RS19780	COG0277	FAD linked oxidase domain protein
AFR_RS19795	COG1063	alcohol dehydrogenase
AFR_RS19830	COG4941	Belongs to the sigma-70 factor family
AFR_RS19835	COG0435	Glutathione S-transferase
AFR_RS19840	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AFR_RS19860	COG0514	ATP-dependent DNA helicase (RecQ)
AFR_RS19880	COG1366	Belongs to the anti-sigma-factor antagonist family
AFR_RS19880	COG2172	sigma factor antagonist activity
AFR_RS19880	COG2208	phosphoserine phosphatase activity
AFR_RS19885	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFR_RS19890	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFR_RS19890	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFR_RS19905	COG0438	transferase activity, transferring glycosyl groups
AFR_RS19920	COG1183	phosphatidylcholine synthase activity
AFR_RS19925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AFR_RS19945	COG2233	PERMEase
AFR_RS19955	COG0789	Transcriptional regulator
AFR_RS19985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFR_RS19985	COG0543	2 iron, 2 sulfur cluster binding
AFR_RS19990	COG0326	Molecular chaperone. Has ATPase activity
AFR_RS20000	COG2130	NADP-dependent
AFR_RS20050	COG0477	Major facilitator Superfamily
AFR_RS20060	COG1309	transcriptional regulator
AFR_RS20080	COG0577	efflux transmembrane transporter activity
AFR_RS20080	COG1136	(ABC) transporter
AFR_RS20090	COG4585	Histidine kinase
AFR_RS20095	COG2201	protein-glutamate methylesterase activity
AFR_RS20115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AFR_RS20120	COG4565	transcriptional regulatory protein
AFR_RS20130	COG1301	dicarboxylic acid transport
AFR_RS20140	COG1609	Transcriptional regulator
AFR_RS20170	COG0659	secondary active sulfate transmembrane transporter activity
AFR_RS20180	COG0477	Major facilitator Superfamily
AFR_RS20190	COG1595	DNA-templated transcription, initiation
AFR_RS20220	COG1132	(ABC) transporter
AFR_RS20225	COG2814	Major facilitator Superfamily
AFR_RS20250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS20300	COG2815	serine threonine protein kinase
AFR_RS20300	COG0515	serine threonine protein kinase
AFR_RS20305	COG4988	ABC transporter
AFR_RS20310	COG1294	oxidase, subunit
AFR_RS20315	COG1271	oxidase subunit
AFR_RS20340	COG1846	Transcriptional regulator
AFR_RS20345	COG0596	Alpha beta hydrolase
AFR_RS20350	COG5002	protein histidine kinase activity
AFR_RS20350	COG5001	Diguanylate cyclase
AFR_RS20350	COG3447	MASE1 domain protein
AFR_RS20355	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS20365	COG0596	Alpha beta hydrolase
AFR_RS20370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFR_RS20420	COG2188	Transcriptional regulator
AFR_RS20425	COG0159	tryptophan synthase activity
AFR_RS20430	COG0133	tryptophan synthase activity
AFR_RS20450	COG2197	response regulator
AFR_RS20455	COG4585	Histidine kinase
AFR_RS20460	COG0596	Alpha beta hydrolase
AFR_RS20485	COG0745	RESPONSE REGULATOR receiver
AFR_RS20505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AFR_RS20525	COG0640	Transcriptional regulator
AFR_RS20545	COG2197	response regulator
AFR_RS20550	COG4585	Histidine kinase
AFR_RS20580	COG0693	protein deglycase activity
AFR_RS20580	COG0753	catalase activity
AFR_RS20595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AFR_RS20600	COG2011	ABC-type metal ion transport system permease component
AFR_RS20605	COG1464	Belongs to the NlpA lipoprotein family
AFR_RS20620	COG0166	Belongs to the GPI family
AFR_RS20635	COG1280	lysine exporter protein (LysE YggA)
AFR_RS20650	COG0588	phosphoglycerate mutase activity
AFR_RS20660	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS20670	COG1940	carbohydrate kinase activity
AFR_RS20675	COG2814	Major facilitator Superfamily
AFR_RS20680	COG4948	Mandelate Racemase Muconate Lactonizing
AFR_RS20695	COG3842	ATPase activity
AFR_RS20705	COG1609	Transcriptional regulator
AFR_RS20710	COG1609	Transcriptional regulator
AFR_RS20735	COG0745	RESPONSE REGULATOR receiver
AFR_RS20740	COG2205	protein histidine kinase activity
AFR_RS20750	COG1136	(ABC) transporter
AFR_RS20755	COG1136	(ABC) transporter
AFR_RS20755	COG0577	efflux transmembrane transporter activity
AFR_RS20800	COG3384	dioxygenase
AFR_RS20840	COG3226	Transcriptional regulator
AFR_RS20855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFR_RS20865	COG3718	enzyme involved in inositol metabolism
AFR_RS20870	COG3962	Belongs to the TPP enzyme family
AFR_RS20900	COG0673	inositol 2-dehydrogenase activity
AFR_RS20905	COG1082	Xylose isomerase domain protein TIM barrel
AFR_RS20915	COG0673	inositol 2-dehydrogenase activity
AFR_RS20920	COG1609	Transcriptional regulator
AFR_RS20930	COG1082	Xylose isomerase domain protein TIM barrel
AFR_RS20940	COG1609	Transcriptional regulator
AFR_RS20955	COG2050	protein possibly involved in aromatic compounds catabolism
AFR_RS20965	COG0183	Belongs to the thiolase family
AFR_RS20970	COG1024	Enoyl-CoA hydratase
AFR_RS20975	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFR_RS20980	COG3396	Phenylacetate-CoA oxygenase
AFR_RS20985	COG3460	Phenylacetate-CoA oxygenase
AFR_RS20990	COG3396	Phenylacetate-CoA oxygenase
AFR_RS20995	COG2151	metal-sulfur cluster biosynthetic enzyme
AFR_RS21000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFR_RS21015	COG0667	Aldo Keto reductase
AFR_RS21025	COG2226	methyltransferase
AFR_RS21055	COG1595	DNA-templated transcription, initiation
AFR_RS21065	COG2409	Drug exporters of the RND superfamily
AFR_RS21075	COG2197	response regulator
AFR_RS21085	COG1131	(ABC) transporter
AFR_RS21120	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AFR_RS21190	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AFR_RS21195	COG0297	glycogen (starch) synthase activity
AFR_RS21205	COG1649	PFAM Uncharacterised BCR, COG1649
AFR_RS21210	COG0488	(ABC) transporter
AFR_RS21215	COG0384	phenazine biosynthesis protein PhzF
AFR_RS21220	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AFR_RS21250	COG0509	glycine decarboxylation via glycine cleavage system
AFR_RS21255	COG1716	ATPase activity
AFR_RS21275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AFR_RS21290	COG0583	DNA-binding transcription factor activity
AFR_RS21305	COG2226	methyltransferase
AFR_RS21325	COG0745	RESPONSE REGULATOR receiver
AFR_RS21330	COG2205	protein histidine kinase activity
AFR_RS21360	COG0667	Aldo Keto reductase
AFR_RS21365	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFR_RS21365	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFR_RS21375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AFR_RS21390	COG1595	DNA-templated transcription, initiation
AFR_RS21395	COG0242	peptide deformylase activity
AFR_RS21405	COG0494	nUDIX hydrolase
AFR_RS21410	COG0019	diaminopimelate decarboxylase activity
AFR_RS21435	COG1131	(ABC) transporter
AFR_RS21445	COG4585	Histidine kinase
AFR_RS21450	COG2197	response regulator
AFR_RS21470	COG0488	(ABC) transporter
AFR_RS21475	COG4974	Belongs to the 'phage' integrase family
AFR_RS21480	COG1968	undecaprenyl-diphosphatase activity
AFR_RS21525	COG2270	Major facilitator Superfamily
AFR_RS21575	COG2362	D-Aminopeptidase
AFR_RS21580	COG0204	Acyl-transferase
AFR_RS21605	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS21615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AFR_RS21620	COG1309	transcriptional regulator
AFR_RS21645	COG2267	carboxylic ester hydrolase activity
AFR_RS21650	COG1764	response to oxidative stress
AFR_RS21655	COG1846	Transcriptional regulator
AFR_RS21670	COG4702	Belongs to the UPF0303 family
AFR_RS21690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS21725	COG2197	response regulator
AFR_RS21740	COG4585	Histidine kinase
AFR_RS21745	COG2197	response regulator
AFR_RS21760	COG2267	carboxylic ester hydrolase activity
AFR_RS21765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFR_RS21825	COG1609	Transcriptional regulator
AFR_RS21835	COG1175	transmembrane transport
AFR_RS21840	COG0395	ABC-type sugar transport system, permease component
AFR_RS21855	COG2197	response regulator
AFR_RS21860	COG4585	Histidine kinase
AFR_RS21875	COG4257	antibiotic catabolic process
AFR_RS21880	COG1404	Belongs to the peptidase S8 family
AFR_RS21925	COG2205	protein histidine kinase activity
AFR_RS21925	COG0784	Response regulator, receiver
AFR_RS21925	COG5002	protein histidine kinase activity
AFR_RS21945	COG0463	Glycosyl transferase, family 2
AFR_RS21960	COG1607	acyl-coa hydrolase
AFR_RS21965	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFR_RS21970	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AFR_RS21980	COG0604	alcohol dehydrogenase
AFR_RS21985	COG1509	lysine 2,3-aminomutase activity
AFR_RS21990	COG3237	CsbD-like
AFR_RS22020	COG1960	acyl-CoA dehydrogenase activity
AFR_RS22025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AFR_RS22030	COG5001	Diguanylate cyclase
AFR_RS22040	COG1309	transcriptional regulator
AFR_RS22045	COG0400	carboxylic ester hydrolase activity
AFR_RS22085	COG2197	response regulator
AFR_RS22155	COG3546	catalase activity
AFR_RS22170	COG1914	H( )-stimulated, divalent metal cation uptake system
AFR_RS22175	COG0745	RESPONSE REGULATOR receiver
AFR_RS22250	COG2814	Major facilitator Superfamily
AFR_RS22295	COG4221	oxidoreductase activity
AFR_RS22390	COG0583	DNA-binding transcription factor activity
AFR_RS22405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_RS22410	COG1116	anion transmembrane transporter activity
AFR_RS22420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS22435	COG0277	FAD linked oxidase domain protein
AFR_RS22450	COG0251	oxidation-reduction process
AFR_RS22455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS22460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFR_RS22465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_RS22470	COG1116	anion transmembrane transporter activity
AFR_RS22475	COG4682	membrane
AFR_RS22490	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AFR_RS22495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS22500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS22505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS22510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS22520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFR_RS22530	COG0747	negative chemotaxis
AFR_RS22560	COG0531	amino acid
AFR_RS22570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AFR_RS22585	COG1501	Belongs to the glycosyl hydrolase 31 family
AFR_RS22595	COG1175	transmembrane transport
AFR_RS22615	COG1609	Transcriptional regulator
AFR_RS22650	COG1105	Belongs to the carbohydrate kinase PfkB family
AFR_RS22685	COG0395	ABC-type sugar transport system, permease component
AFR_RS22690	COG1175	transmembrane transport
AFR_RS22695	COG2182	Extracellular solute-binding protein
AFR_RS22700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AFR_RS22705	COG1486	melibiose metabolic process
AFR_RS22710	COG1349	DNA-binding transcription factor activity
AFR_RS22715	COG3201	nicotinamide mononucleotide transporter
AFR_RS22770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFR_RS22775	COG0789	Transcriptional regulator
AFR_RS22790	COG0142	geranyltranstransferase activity
AFR_RS22830	COG0515	serine threonine protein kinase
AFR_RS22830	COG2815	serine threonine protein kinase
AFR_RS22850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFR_RS22880	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AFR_RS22890	COG0148	phosphopyruvate hydratase activity
AFR_RS22895	COG0789	Transcriptional regulator
AFR_RS22900	COG0303	'Molybdopterin
AFR_RS22905	COG2226	methyltransferase
AFR_RS22920	COG0840	transmembrane signaling receptor activity
AFR_RS22940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AFR_RS22940	COG2080	2 iron, 2 sulfur cluster binding
AFR_RS22965	COG0745	RESPONSE REGULATOR receiver
AFR_RS22970	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AFR_RS23005	COG0657	acetylesterase activity
AFR_RS23030	COG1752	Esterase of the alpha-beta hydrolase superfamily
AFR_RS23035	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AFR_RS23045	COG0667	Aldo Keto reductase
AFR_RS23055	COG0483	inositol monophosphate 1-phosphatase activity
AFR_RS23070	COG0477	Major facilitator Superfamily
AFR_RS23085	COG0596	Alpha beta hydrolase
AFR_RS23130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFR_RS23135	COG1309	transcriptional regulator
AFR_RS23150	COG1366	Belongs to the anti-sigma-factor antagonist family
AFR_RS23160	COG0702	epimerase
AFR_RS23165	COG1309	transcriptional regulator
AFR_RS23180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFR_RS23180	COG1017	nitric oxide dioxygenase activity
AFR_RS23200	COG4221	oxidoreductase activity
AFR_RS23215	COG0596	Alpha beta hydrolase
AFR_RS23220	COG0596	Alpha beta hydrolase
AFR_RS23230	COG0587	DNA-directed DNA polymerase activity
AFR_RS23275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS23285	COG0778	Nitroreductase
AFR_RS23305	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AFR_RS23345	COG2217	Heavy metal translocating P-type atpase
AFR_RS23395	COG2376	Dihydroxyacetone kinase
AFR_RS23405	COG0640	Transcriptional regulator
AFR_RS23425	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AFR_RS23465	COG1216	Glycosyl transferase, family 2
AFR_RS23470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AFR_RS23475	COG0438	transferase activity, transferring glycosyl groups
AFR_RS23500	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS23540	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AFR_RS23570	COG1063	alcohol dehydrogenase
AFR_RS23580	COG1819	glycosyl
AFR_RS23585	COG3973	AAA domain
AFR_RS23605	COG1595	DNA-templated transcription, initiation
AFR_RS23625	COG2205	protein histidine kinase activity
AFR_RS23675	COG0640	Transcriptional regulator
AFR_RS23690	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS23695	COG0596	Alpha beta hydrolase
AFR_RS23715	COG2273	Hydrolase Family 16
AFR_RS23730	COG2826	transposase and inactivated derivatives, IS30 family
AFR_RS23745	COG0726	polysaccharide deacetylase
AFR_RS23770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFR_RS23775	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFR_RS23780	COG1120	ATPase activity
AFR_RS23790	COG1132	(ABC) transporter
AFR_RS23825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AFR_RS23835	COG3976	FMN-binding domain protein
AFR_RS23835	COG0431	NADPH-dependent FMN reductase
AFR_RS23835	COG1053	succinate dehydrogenase
AFR_RS23845	COG1414	Transcriptional regulator
AFR_RS23865	COG3384	dioxygenase
AFR_RS23875	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AFR_RS23890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFR_RS23900	COG3971	2-oxopent-4-enoate hydratase activity
AFR_RS23905	COG1414	Transcriptional regulator
AFR_RS23945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AFR_RS23980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFR_RS24005	COG0300	oxidoreductase activity
AFR_RS24015	COG1595	DNA-templated transcription, initiation
AFR_RS24060	COG1595	DNA-templated transcription, initiation
AFR_RS24065	COG3795	YCII-related domain
AFR_RS24070	COG4941	Belongs to the sigma-70 factor family
AFR_RS24075	COG1846	Transcriptional regulator
AFR_RS24080	COG0697	spore germination
AFR_RS24095	COG0583	DNA-binding transcription factor activity
AFR_RS24110	COG1653	transport
AFR_RS24115	COG1175	transmembrane transport
AFR_RS24120	COG0395	ABC-type sugar transport system, permease component
AFR_RS24125	COG0058	SHG alpha-glucan phosphorylase activity
AFR_RS24145	COG2205	protein histidine kinase activity
AFR_RS24170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AFR_RS24200	COG1131	(ABC) transporter
AFR_RS24205	COG0745	RESPONSE REGULATOR receiver
AFR_RS24210	COG2205	protein histidine kinase activity
AFR_RS24265	COG1620	l-lactate permease
AFR_RS24335	COG0366	Alpha amylase catalytic
AFR_RS24340	COG2197	response regulator
AFR_RS24350	COG0577	efflux transmembrane transporter activity
AFR_RS24350	COG1136	(ABC) transporter
AFR_RS24365	COG1309	transcriptional regulator
AFR_RS24385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFR_RS24390	COG0747	negative chemotaxis
AFR_RS24430	COG2770	Histidine kinase
AFR_RS24430	COG2208	phosphoserine phosphatase activity
AFR_RS24445	COG2890	protein-(glutamine-N5) methyltransferase activity
AFR_RS24450	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AFR_RS24470	COG0306	phosphate transporter
AFR_RS24480	COG1309	transcriptional regulator
AFR_RS24530	COG3842	ATPase activity
AFR_RS24535	COG1178	ABC-type Fe3 transport system permease component
AFR_RS24540	COG1840	ABC-type Fe3 transport system, periplasmic component
AFR_RS24545	COG0745	RESPONSE REGULATOR receiver
AFR_RS24550	COG5002	protein histidine kinase activity
AFR_RS24555	COG2175	clavaminate synthase activity
AFR_RS24560	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AFR_RS24565	COG4521	taurine ABC transporter
AFR_RS24570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_RS24580	COG3795	YCII-related domain
AFR_RS24585	COG4941	Belongs to the sigma-70 factor family
AFR_RS24590	COG2226	methyltransferase
AFR_RS24625	COG1376	ErfK ybiS ycfS ynhG family protein
AFR_RS24635	COG0477	Major facilitator Superfamily
AFR_RS24655	COG1609	Transcriptional regulator
AFR_RS24675	COG0456	acetyltransferase
AFR_RS24690	COG0701	Predicted permease
AFR_RS24715	COG2022	thiamine diphosphate biosynthetic process
AFR_RS24715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFR_RS24745	COG2197	response regulator
AFR_RS24750	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AFR_RS24765	COG1595	DNA-templated transcription, initiation
AFR_RS24790	COG0667	Aldo Keto reductase
AFR_RS24825	COG2255	four-way junction helicase activity
AFR_RS24855	COG1595	DNA-templated transcription, initiation
AFR_RS24905	COG3250	beta-galactosidase activity
AFR_RS24945	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS24965	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AFR_RS24970	COG5001	Diguanylate cyclase
AFR_RS24975	COG3851	Histidine kinase
AFR_RS24980	COG2197	response regulator
AFR_RS25000	COG3022	response to hydroperoxide
AFR_RS25025	COG1733	regulation of RNA biosynthetic process
AFR_RS25050	COG4279	zinc finger
AFR_RS25055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AFR_RS25080	COG1846	Transcriptional regulator
AFR_RS25085	COG0477	Major facilitator Superfamily
AFR_RS25090	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFR_RS25105	COG0531	amino acid
AFR_RS25120	COG0515	serine threonine protein kinase
AFR_RS25145	COG0463	Glycosyl transferase, family 2
AFR_RS25170	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AFR_RS25195	COG1408	metallophosphoesterase
AFR_RS25210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFR_RS25235	COG1609	Transcriptional regulator
AFR_RS25250	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AFR_RS25250	COG1672	PFAM Archaeal ATPase
AFR_RS25260	COG1619	proteins homologs of microcin C7 resistance protein MccF
AFR_RS25280	COG0277	FAD linked oxidase domain protein
AFR_RS25295	COG2072	flavoprotein involved in K transport
AFR_RS25305	COG3158	transport of potassium into the cell
AFR_RS25330	COG1960	acyl-CoA dehydrogenase activity
AFR_RS25350	COG3940	Belongs to the glycosyl hydrolase 43 family
AFR_RS25405	COG0246	Mannitol dehydrogenase
AFR_RS25410	COG4948	Mandelate Racemase Muconate Lactonizing
AFR_RS25415	COG1904	glucuronate isomerase
AFR_RS25420	COG0673	inositol 2-dehydrogenase activity
AFR_RS25435	COG1175	transmembrane transport
AFR_RS25440	COG0395	ABC-type sugar transport system, permease component
AFR_RS25505	COG0656	L-ascorbic acid biosynthetic process
AFR_RS25545	COG0395	ABC-type sugar transport system, permease component
AFR_RS25550	COG1175	transmembrane transport
AFR_RS25560	COG2501	S4 domain
AFR_RS25575	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AFR_RS25585	COG1366	Belongs to the anti-sigma-factor antagonist family
AFR_RS25595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AFR_RS25615	COG4214	carbohydrate transport
AFR_RS25630	COG2205	protein histidine kinase activity
AFR_RS25640	COG0745	RESPONSE REGULATOR receiver
AFR_RS25645	COG1940	carbohydrate kinase activity
AFR_RS25670	COG4214	carbohydrate transport
AFR_RS25675	COG1129	ABC transporter
AFR_RS25680	COG4213	ABC transporter substrate-binding protein
AFR_RS25685	COG2160	L-arabinose isomerase activity
AFR_RS25700	COG1609	Transcriptional regulator
AFR_RS25745	COG3706	GGDEF domain
AFR_RS25755	COG0577	efflux transmembrane transporter activity
AFR_RS25755	COG1136	(ABC) transporter
AFR_RS25760	COG0577	efflux transmembrane transporter activity
AFR_RS25760	COG1136	(ABC) transporter
AFR_RS25765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFR_RS25795	COG2197	response regulator
AFR_RS25800	COG3850	Histidine kinase
AFR_RS25820	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AFR_RS25835	COG2198	Histidine kinase
AFR_RS25835	COG0643	Histidine kinase
AFR_RS25840	COG2201	protein-glutamate methylesterase activity
AFR_RS25845	COG4251	negative regulation of phosphorylation
AFR_RS25865	COG0657	acetylesterase activity
AFR_RS25870	COG0577	efflux transmembrane transporter activity
AFR_RS25870	COG1136	(ABC) transporter
AFR_RS25875	COG0577	efflux transmembrane transporter activity
AFR_RS25875	COG1136	(ABC) transporter
AFR_RS25885	COG2197	response regulator
AFR_RS25930	COG0726	polysaccharide deacetylase
AFR_RS25945	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AFR_RS25955	COG5297	Belongs to the glycosyl hydrolase family 6
AFR_RS26030	COG1063	alcohol dehydrogenase
AFR_RS26035	COG1733	regulation of RNA biosynthetic process
AFR_RS26060	COG1960	acyl-CoA dehydrogenase activity
AFR_RS26075	COG3903	Transcriptional regulator
AFR_RS26075	COG3629	intracellular signal transduction
AFR_RS26090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFR_RS26100	COG3629	intracellular signal transduction
AFR_RS26100	COG3903	Transcriptional regulator
AFR_RS26115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFR_RS26120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFR_RS26165	COG2197	response regulator
AFR_RS26170	COG4585	Histidine kinase
AFR_RS26175	COG2409	Drug exporters of the RND superfamily
AFR_RS26200	COG1280	lysine exporter protein (LysE YggA)
AFR_RS26220	COG1653	transport
AFR_RS26230	COG3548	integral membrane protein
AFR_RS26255	COG4948	Mandelate Racemase Muconate Lactonizing
AFR_RS26260	COG0395	ABC-type sugar transport system, permease component
AFR_RS26265	COG1175	transmembrane transport
AFR_RS26270	COG1653	transport
AFR_RS26285	COG2084	Dehydrogenase
AFR_RS26330	COG2197	response regulator
AFR_RS26335	COG4585	Histidine kinase
AFR_RS26340	COG1136	(ABC) transporter
AFR_RS26340	COG0577	efflux transmembrane transporter activity
AFR_RS26350	COG0318	PFAM AMP-dependent synthetase and ligase
AFR_RS26360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFR_RS26370	COG0515	serine threonine protein kinase
AFR_RS26380	COG2304	oxidoreductase activity
AFR_RS26390	COG2318	DinB family
AFR_RS26405	COG0483	inositol monophosphate 1-phosphatase activity
AFR_RS26420	COG3866	Pectate lyase
AFR_RS26445	COG1609	Transcriptional regulator
AFR_RS26455	COG4581	dead DEAH box helicase
AFR_RS26460	COG0546	phosphoglycolate phosphatase activity
AFR_RS26475	COG0805	protein transport
AFR_RS26480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFR_RS26490	COG2378	regulation of single-species biofilm formation
AFR_RS26525	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AFR_RS26535	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AFR_RS26540	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AFR_RS26550	COG4122	O-methyltransferase activity
AFR_RS26555	COG1222	aaa ATPase
AFR_RS26560	COG1141	Ferredoxin
AFR_RS26575	COG0517	IMP dehydrogenase activity
AFR_RS26575	COG1994	Peptidase M50
AFR_RS26585	COG2197	response regulator
AFR_RS26600	COG1136	(ABC) transporter
AFR_RS26605	COG0577	efflux transmembrane transporter activity
AFR_RS26605	COG1136	(ABC) transporter
AFR_RS26665	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AFR_RS26680	COG1280	lysine exporter protein (LysE YggA)
AFR_RS26725	COG1136	(ABC) transporter
AFR_RS26750	COG1846	Transcriptional regulator
AFR_RS26755	COG1902	pentaerythritol trinitrate reductase activity
AFR_RS26760	COG0215	cysteine-tRNA ligase activity
AFR_RS26780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS26785	COG0667	Aldo Keto reductase
AFR_RS26810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFR_RS26825	COG0542	response to heat
AFR_RS26840	COG1674	ftsk spoiiie
AFR_RS26885	COG0745	RESPONSE REGULATOR receiver
AFR_RS26905	COG0653	protein targeting
AFR_RS26910	COG1132	(ABC) transporter
AFR_RS26920	COG2201	protein-glutamate methylesterase activity
AFR_RS26970	COG0596	Alpha beta hydrolase
AFR_RS27005	COG2197	response regulator
AFR_RS27010	COG4585	Histidine kinase
AFR_RS27015	COG1396	sequence-specific DNA binding
AFR_RS27045	COG1797	cobyrinic acid a,c-diamide synthase activity
AFR_RS27060	COG1070	Carbohydrate kinase
AFR_RS27070	COG1191	sigma factor activity
AFR_RS27080	COG0640	Transcriptional regulator
AFR_RS27085	COG1819	glycosyl
AFR_RS27100	COG5001	Diguanylate cyclase
AFR_RS27105	COG0708	Exodeoxyribonuclease III
AFR_RS27140	COG3300	MHYT domain
AFR_RS27140	COG5001	Diguanylate cyclase
AFR_RS27145	COG1643	Atp-dependent helicase
AFR_RS27150	COG0656	L-ascorbic acid biosynthetic process
AFR_RS27160	COG5002	protein histidine kinase activity
AFR_RS27180	COG1191	sigma factor activity
AFR_RS27235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AFR_RS27240	COG0456	acetyltransferase
AFR_RS27260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFR_RS27285	COG2183	response to ionizing radiation
AFR_RS27315	COG2068	MobA-Related Protein
AFR_RS27420	COG5297	Belongs to the glycosyl hydrolase family 6
AFR_RS27460	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AFR_RS27470	COG1609	Transcriptional regulator
AFR_RS27495	COG0673	inositol 2-dehydrogenase activity
AFR_RS27515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AFR_RS27520	COG1960	acyl-CoA dehydrogenase activity
AFR_RS27550	COG0584	glycerophosphoryl diester phosphodiesterase
AFR_RS27560	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AFR_RS27565	COG1414	Transcriptional regulator
AFR_RS27570	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AFR_RS27575	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AFR_RS27580	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AFR_RS27610	COG1472	Belongs to the glycosyl hydrolase 3 family
AFR_RS27635	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AFR_RS27670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AFR_RS27685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_RS27695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_RS27700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFR_RS27725	COG2203	Gaf domain
AFR_RS27725	COG4251	negative regulation of phosphorylation
AFR_RS27725	COG3706	GGDEF domain
AFR_RS27725	COG5001	Diguanylate cyclase
AFR_RS27745	COG4213	ABC transporter substrate-binding protein
AFR_RS27750	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFR_RS27760	COG2409	Drug exporters of the RND superfamily
AFR_RS27775	COG1132	(ABC) transporter
AFR_RS27780	COG5002	protein histidine kinase activity
AFR_RS27800	COG1136	(ABC) transporter
AFR_RS27800	COG0577	efflux transmembrane transporter activity
AFR_RS27805	COG0577	efflux transmembrane transporter activity
AFR_RS27805	COG1136	(ABC) transporter
AFR_RS27810	COG1252	NADH dehydrogenase
AFR_RS27850	COG0366	Alpha amylase catalytic
AFR_RS27880	COG1053	succinate dehydrogenase
AFR_RS27895	COG1012	belongs to the aldehyde dehydrogenase family
AFR_RS27915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AFR_RS27920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFR_RS27935	COG0515	serine threonine protein kinase
AFR_RS27945	COG1725	Transcriptional regulator
AFR_RS27985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFR_RS27990	COG0438	transferase activity, transferring glycosyl groups
AFR_RS28010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AFR_RS28030	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AFR_RS28050	COG0515	serine threonine protein kinase
AFR_RS28055	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AFR_RS28070	COG1921	L-seryl-tRNASec selenium transferase activity
AFR_RS28080	COG0709	Synthesizes selenophosphate from selenide and ATP
AFR_RS28090	COG0437	4 iron, 4 sulfur cluster binding
AFR_RS28095	COG0243	molybdopterin cofactor binding
AFR_RS28095	COG3383	formate dehydrogenase (NAD+) activity
AFR_RS28100	COG0243	molybdopterin cofactor binding
AFR_RS28100	COG3383	formate dehydrogenase (NAD+) activity
AFR_RS28115	COG0318	PFAM AMP-dependent synthetase and ligase
AFR_RS28125	COG1141	Ferredoxin
AFR_RS28140	COG1715	Restriction endonuclease
AFR_RS28245	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AFR_RS28305	COG3152	Membrane
AFR_RS28330	COG0714	Associated with various cellular activities
AFR_RS28340	COG0642	Histidine kinase
AFR_RS28350	COG3629	intracellular signal transduction
AFR_RS28350	COG3903	Transcriptional regulator
AFR_RS28360	COG0745	RESPONSE REGULATOR receiver
AFR_RS28365	COG1733	regulation of RNA biosynthetic process
AFR_RS28400	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AFR_RS28455	COG0456	acetyltransferase
AFR_RS28465	COG3903	Transcriptional regulator
AFR_RS28465	COG2197	response regulator
AFR_RS28490	COG2124	cytochrome p450
AFR_RS28500	COG1960	acyl-CoA dehydrogenase activity
AFR_RS28510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AFR_RS28540	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AFR_RS28555	COG3119	arylsulfatase activity
AFR_RS28605	COG4251	negative regulation of phosphorylation
AFR_RS28605	COG5001	Diguanylate cyclase
AFR_RS28605	COG3706	GGDEF domain
AFR_RS28605	COG2203	Gaf domain
AFR_RS28610	COG1082	Xylose isomerase domain protein TIM barrel
AFR_RS28615	COG2133	pyrroloquinoline quinone binding
AFR_RS28625	COG2205	protein histidine kinase activity
AFR_RS28630	COG0745	RESPONSE REGULATOR receiver
AFR_RS28650	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AFR_RS28655	COG0778	Nitroreductase
AFR_RS28665	COG0604	alcohol dehydrogenase
AFR_RS28665	COG3321	synthase
AFR_RS28665	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS28695	COG3285	dna ligase
AFR_RS28695	COG1793	dna ligase
AFR_RS28700	COG3226	Transcriptional regulator
AFR_RS28705	COG2267	carboxylic ester hydrolase activity
AFR_RS28720	COG0577	efflux transmembrane transporter activity
AFR_RS28725	COG1136	(ABC) transporter
AFR_RS28725	COG0577	efflux transmembrane transporter activity
AFR_RS28735	COG0745	RESPONSE REGULATOR receiver
AFR_RS28740	COG2205	protein histidine kinase activity
AFR_RS28745	COG2205	protein histidine kinase activity
AFR_RS28750	COG0745	RESPONSE REGULATOR receiver
AFR_RS28760	COG0463	Glycosyl transferase, family 2
AFR_RS28795	COG2267	carboxylic ester hydrolase activity
AFR_RS28820	COG1408	metallophosphoesterase
AFR_RS28835	COG1408	metallophosphoesterase
AFR_RS28840	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS28890	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AFR_RS28895	COG2197	response regulator
AFR_RS28905	COG0515	serine threonine protein kinase
AFR_RS28925	COG2197	response regulator
AFR_RS28950	COG4585	Histidine kinase
AFR_RS28955	COG2197	response regulator
AFR_RS28995	COG1131	(ABC) transporter
AFR_RS29015	COG1073	alpha beta
AFR_RS29030	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS29035	COG1309	transcriptional regulator
AFR_RS29075	COG4585	Histidine kinase
AFR_RS29090	COG2267	carboxylic ester hydrolase activity
AFR_RS29095	COG0596	Alpha beta hydrolase
AFR_RS29125	COG2226	methyltransferase
AFR_RS29200	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AFR_RS29205	COG2186	Transcriptional regulator
AFR_RS29215	COG3618	amidohydrolase
AFR_RS29230	COG0395	ABC-type sugar transport system, permease component
AFR_RS29235	COG1175	transmembrane transport
AFR_RS29245	COG1063	alcohol dehydrogenase
AFR_RS29250	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS29255	COG1733	regulation of RNA biosynthetic process
AFR_RS29260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFR_RS29285	COG3345	alpha-galactosidase
AFR_RS29305	COG3507	Belongs to the glycosyl hydrolase 43 family
AFR_RS29340	COG1132	(ABC) transporter
AFR_RS29355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AFR_RS29360	COG1234	tRNA 3'-trailer cleavage
AFR_RS29385	COG0583	DNA-binding transcription factor activity
AFR_RS29395	COG0300	oxidoreductase activity
AFR_RS29405	COG0114	fumarate hydratase activity
AFR_RS29415	COG0154	amidase activity
AFR_RS29420	COG0702	epimerase
AFR_RS29435	COG0596	Alpha beta hydrolase
AFR_RS29440	COG1917	Cupin 2, conserved barrel domain protein
AFR_RS29440	COG4977	sequence-specific DNA binding
AFR_RS29525	COG1136	(ABC) transporter
AFR_RS29525	COG0577	efflux transmembrane transporter activity
AFR_RS29530	COG1136	(ABC) transporter
AFR_RS29540	COG0745	RESPONSE REGULATOR receiver
AFR_RS29545	COG5002	protein histidine kinase activity
AFR_RS29570	COG3903	Transcriptional regulator
AFR_RS29570	COG3629	intracellular signal transduction
AFR_RS29595	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS29600	COG1741	Belongs to the pirin family
AFR_RS29620	COG2814	Major facilitator Superfamily
AFR_RS29685	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AFR_RS29695	COG1201	RNA secondary structure unwinding
AFR_RS29745	COG1160	GTP binding
AFR_RS29750	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AFR_RS29760	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AFR_RS29770	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AFR_RS29780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFR_RS29890	COG0702	epimerase
AFR_RS30015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS30020	COG0494	nUDIX hydrolase
AFR_RS30025	COG0504	CTP synthase activity
AFR_RS30035	COG0438	transferase activity, transferring glycosyl groups
AFR_RS30065	COG0497	DNA recombination
AFR_RS30070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AFR_RS30095	COG1131	(ABC) transporter
AFR_RS30115	COG2197	response regulator
AFR_RS30120	COG0647	UMP catabolic process
AFR_RS30150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AFR_RS30165	COG2326	polyphosphate kinase activity
AFR_RS30170	COG0563	adenylate kinase activity
AFR_RS30205	COG2094	Belongs to the DNA glycosylase MPG family
AFR_RS30220	COG3537	Alpha-1,2-mannosidase
AFR_RS30230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AFR_RS30235	COG0406	alpha-ribazole phosphatase activity
AFR_RS30250	COG1175	transmembrane transport
AFR_RS30255	COG0395	ABC-type sugar transport system, permease component
AFR_RS30265	COG0490	domain, Protein
AFR_RS30270	COG3851	Histidine kinase
AFR_RS30275	COG2197	response regulator
AFR_RS30280	COG2111	Na H antiporter
AFR_RS30280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AFR_RS30285	COG1006	Multisubunit Na H antiporter MnhC subunit
AFR_RS30290	COG0651	ATP synthesis coupled electron transport
AFR_RS30300	COG2212	antiporter activity
AFR_RS30305	COG1320	monovalent cation:proton antiporter activity
AFR_RS30340	COG0730	response to heat
AFR_RS30350	COG1192	Involved in chromosome partitioning
AFR_RS30355	COG0165	Argininosuccinate lyase
AFR_RS30360	COG0137	argininosuccinate synthase activity
AFR_RS30370	COG1438	arginine binding
AFR_RS30375	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AFR_RS30380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AFR_RS30385	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AFR_RS30390	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AFR_RS30395	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AFR_RS30455	COG1131	(ABC) transporter
AFR_RS30460	COG4585	Histidine kinase
AFR_RS30465	COG2197	response regulator
AFR_RS30535	COG1725	Transcriptional regulator
AFR_RS30540	COG1131	(ABC) transporter
AFR_RS30565	COG2226	methyltransferase
AFR_RS30575	COG2318	DinB family
AFR_RS30590	COG0072	phenylalanine-tRNA ligase activity
AFR_RS30590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFR_RS30595	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AFR_RS30600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFR_RS30605	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AFR_RS30610	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AFR_RS30615	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AFR_RS30625	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AFR_RS30630	COG0140	phosphoribosyl-ATP diphosphatase activity
AFR_RS30635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFR_RS30640	COG0765	amino acid transport
AFR_RS30650	COG2133	pyrroloquinoline quinone binding
AFR_RS30655	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AFR_RS30660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFR_RS30660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFR_RS30675	COG0745	RESPONSE REGULATOR receiver
AFR_RS30700	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AFR_RS30705	COG0242	peptide deformylase activity
AFR_RS30725	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AFR_RS30735	COG1758	RNA polymerase activity
AFR_RS30740	COG0194	GDP metabolic process
AFR_RS30745	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AFR_RS30750	COG0284	orotidine-5'-phosphate decarboxylase activity
AFR_RS30755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AFR_RS30760	COG0167	dihydroorotate dehydrogenase activity
AFR_RS30770	COG0505	Belongs to the CarA family
AFR_RS30775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AFR_RS30780	COG0540	Belongs to the ATCase OTCase family
AFR_RS30785	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AFR_RS30795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AFR_RS30800	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AFR_RS30805	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AFR_RS30810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AFR_RS30830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AFR_RS30835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AFR_RS30840	COG2814	Major facilitator Superfamily
AFR_RS30845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFR_RS30850	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AFR_RS30855	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AFR_RS30860	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AFR_RS30925	COG2205	protein histidine kinase activity
AFR_RS30930	COG0745	RESPONSE REGULATOR receiver
AFR_RS30955	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AFR_RS31010	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AFR_RS31015	COG0395	ABC-type sugar transport system, permease component
AFR_RS31020	COG1175	transmembrane transport
AFR_RS31040	COG3964	amidohydrolase
AFR_RS31055	COG0831	urea catabolic process
AFR_RS31060	COG0832	Belongs to the urease beta subunit family
AFR_RS31065	COG0804	urea catabolic process
AFR_RS31075	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AFR_RS31080	COG0829	nickel cation binding
AFR_RS31095	COG0515	serine threonine protein kinase
AFR_RS31100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AFR_RS31100	COG0189	ligase activity
AFR_RS31110	COG2814	Major facilitator Superfamily
AFR_RS31155	COG4221	oxidoreductase activity
AFR_RS31165	COG0124	histidyl-tRNA synthetase
AFR_RS31180	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AFR_RS31185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFR_RS31190	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AFR_RS31205	COG1862	Preprotein translocase
AFR_RS31210	COG2255	four-way junction helicase activity
AFR_RS31215	COG0632	four-way junction helicase activity
AFR_RS31220	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AFR_RS31230	COG0217	transcriptional regulatory protein
AFR_RS31235	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AFR_RS31240	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AFR_RS31255	COG0438	transferase activity, transferring glycosyl groups
AFR_RS31260	COG1560	Kdo2-lipid A biosynthetic process
AFR_RS31265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AFR_RS31285	COG5001	Diguanylate cyclase
AFR_RS31315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AFR_RS31340	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AFR_RS31345	COG4106	trans-aconitate 2-methyltransferase activity
AFR_RS31350	COG0667	Aldo Keto reductase
AFR_RS31360	COG1278	Cold shock
AFR_RS31400	COG1472	Belongs to the glycosyl hydrolase 3 family
AFR_RS31405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS31410	COG0514	ATP-dependent DNA helicase (RecQ)
AFR_RS31440	COG2197	response regulator
AFR_RS31445	COG3850	Histidine kinase
AFR_RS31455	COG1131	(ABC) transporter
AFR_RS31460	COG0297	glycogen (starch) synthase activity
AFR_RS31470	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS31480	COG1295	ribonuclease BN
AFR_RS31525	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS31575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFR_RS31595	COG2910	NAD(P)H-binding
AFR_RS31620	COG2197	response regulator
AFR_RS31625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AFR_RS31640	COG4266	Belongs to the allantoicase family
AFR_RS31645	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AFR_RS31660	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AFR_RS31690	COG1643	Atp-dependent helicase
AFR_RS31715	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AFR_RS31750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFR_RS31755	COG1216	Glycosyl transferase, family 2
AFR_RS31760	COG0318	PFAM AMP-dependent synthetase and ligase
AFR_RS31790	COG3300	MHYT domain
AFR_RS31790	COG5001	Diguanylate cyclase
AFR_RS31810	COG0840	transmembrane signaling receptor activity
AFR_RS31835	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AFR_RS31840	COG5002	protein histidine kinase activity
AFR_RS31855	COG0405	Gamma-glutamyltransferase
AFR_RS31865	COG1132	(ABC) transporter
AFR_RS31905	COG2936	dipeptidyl-peptidase activity
AFR_RS31910	COG1082	Xylose isomerase domain protein TIM barrel
AFR_RS31925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFR_RS31930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS31935	COG1216	Glycosyl transferase, family 2
AFR_RS31940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS31965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS31980	COG1686	Belongs to the peptidase S11 family
AFR_RS32000	COG1191	sigma factor activity
AFR_RS32005	COG3973	AAA domain
AFR_RS32015	COG1191	sigma factor activity
AFR_RS32020	COG0513	Belongs to the DEAD box helicase family
AFR_RS32035	COG2197	response regulator
AFR_RS32065	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AFR_RS32070	COG1609	Transcriptional regulator
AFR_RS32075	COG4166	transmembrane transport
AFR_RS32085	COG0601	transmembrane transport
AFR_RS32090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFR_RS32100	COG2723	6-phospho-beta-galactosidase activity
AFR_RS32105	COG1940	carbohydrate kinase activity
AFR_RS32130	COG0667	Aldo Keto reductase
AFR_RS32170	COG0187	DNA topoisomerase II activity
AFR_RS32190	COG2197	response regulator
AFR_RS32205	COG2205	protein histidine kinase activity
AFR_RS32210	COG0745	RESPONSE REGULATOR receiver
AFR_RS32215	COG4941	Belongs to the sigma-70 factor family
AFR_RS32220	COG3795	YCII-related domain
AFR_RS32270	COG0387	Pfam Sodium calcium exchanger
AFR_RS32295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFR_RS32310	COG0435	Glutathione S-transferase
AFR_RS32320	COG1846	Transcriptional regulator
AFR_RS32340	COG1309	transcriptional regulator
AFR_RS32355	COG0714	Associated with various cellular activities
AFR_RS32370	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AFR_RS32420	COG1120	ATPase activity
AFR_RS32425	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFR_RS32430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFR_RS32475	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AFR_RS32525	COG1595	DNA-templated transcription, initiation
AFR_RS32535	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AFR_RS32540	COG0633	Ferredoxin
AFR_RS32540	COG0543	2 iron, 2 sulfur cluster binding
AFR_RS32560	COG4221	oxidoreductase activity
AFR_RS32580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFR_RS32635	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AFR_RS32640	COG1136	(ABC) transporter
AFR_RS32650	COG1136	(ABC) transporter
AFR_RS32665	COG0598	Magnesium transport protein CorA
AFR_RS32695	COG2304	oxidoreductase activity
AFR_RS32710	COG0714	Associated with various cellular activities
AFR_RS32720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AFR_RS32725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFR_RS32810	COG0671	phosphoesterase, PA-phosphatase related
AFR_RS32820	COG1803	Methylglyoxal synthase
AFR_RS32820	COG1597	lipid kinase activity
AFR_RS32870	COG2124	cytochrome p450
AFR_RS32890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS32905	COG1116	anion transmembrane transporter activity
AFR_RS32915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_RS32920	COG1960	acyl-CoA dehydrogenase activity
AFR_RS32925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS32935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS32970	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AFR_RS32980	COG2197	response regulator
AFR_RS33005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFR_RS33035	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AFR_RS33050	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS33065	COG0800	Aldolase
AFR_RS33120	COG2814	Major facilitator Superfamily
AFR_RS33130	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AFR_RS33155	COG0366	Alpha amylase catalytic
AFR_RS33165	COG0438	transferase activity, transferring glycosyl groups
AFR_RS33180	COG2197	response regulator
AFR_RS33185	COG2706	6-phosphogluconolactonase activity
AFR_RS33190	COG4585	Histidine kinase
AFR_RS33205	COG5002	protein histidine kinase activity
AFR_RS33205	COG3447	MASE1 domain protein
AFR_RS33205	COG5001	Diguanylate cyclase
AFR_RS33215	COG0673	inositol 2-dehydrogenase activity
AFR_RS33235	COG3483	tryptophan 2,3-dioxygenase activity
AFR_RS33240	COG3012	SEC-C Motif Domain Protein
AFR_RS33245	COG0789	Transcriptional regulator
AFR_RS33275	COG1175	transmembrane transport
AFR_RS33280	COG0395	ABC-type sugar transport system, permease component
AFR_RS33285	COG0366	Alpha amylase catalytic
AFR_RS33300	COG2197	response regulator
AFR_RS33305	COG4585	Histidine kinase
AFR_RS33315	COG0659	secondary active sulfate transmembrane transporter activity
AFR_RS33325	COG0574	Belongs to the PEP-utilizing enzyme family
AFR_RS33325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFR_RS33330	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AFR_RS33330	COG2308	Evidence 4 Homologs of previously reported genes of
AFR_RS33335	COG0367	asparagine synthase
AFR_RS33340	COG1506	peptidase
AFR_RS33370	COG3852	Histidine kinase
AFR_RS33385	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AFR_RS33395	COG1278	Cold shock
AFR_RS33410	COG2814	Major facilitator Superfamily
AFR_RS33420	COG2375	cellular response to nickel ion
AFR_RS33460	COG3250	beta-galactosidase activity
AFR_RS33475	COG1063	alcohol dehydrogenase
AFR_RS33480	COG4585	Histidine kinase
AFR_RS33485	COG2197	response regulator
AFR_RS33495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFR_RS33510	COG0539	negative regulation of cytoplasmic translation
AFR_RS33525	COG2318	DinB family
AFR_RS33535	COG1136	(ABC) transporter
AFR_RS33545	COG0640	Transcriptional regulator
AFR_RS33660	COG2197	response regulator
AFR_RS33665	COG4585	Histidine kinase
AFR_RS33690	COG0328	RNA-DNA hybrid ribonuclease activity
AFR_RS33700	COG2132	Multicopper oxidase
AFR_RS33715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS33720	COG0596	Alpha beta hydrolase
AFR_RS33730	COG2154	pterin-4-alpha-carbinolamine dehydratase
AFR_RS33800	COG1793	dna ligase
AFR_RS33800	COG3285	dna ligase
AFR_RS33815	COG2197	response regulator
AFR_RS33825	COG3537	Alpha-1,2-mannosidase
AFR_RS33830	COG3467	pyridoxamine 5'-phosphate
AFR_RS33850	COG5001	Diguanylate cyclase
AFR_RS33920	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AFR_RS33925	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AFR_RS33935	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AFR_RS33965	COG0702	epimerase
AFR_RS34020	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFR_RS34030	COG0277	FAD linked oxidase domain protein
AFR_RS34080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AFR_RS34095	COG2201	protein-glutamate methylesterase activity
AFR_RS34130	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFR_RS34160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFR_RS34195	COG4974	Belongs to the 'phage' integrase family
AFR_RS34225	COG2409	Drug exporters of the RND superfamily
AFR_RS34235	COG0243	molybdopterin cofactor binding
AFR_RS34245	COG1404	Belongs to the peptidase S8 family
AFR_RS34265	COG1376	ErfK ybiS ycfS ynhG family protein
AFR_RS34285	COG0745	RESPONSE REGULATOR receiver
AFR_RS34290	COG2205	protein histidine kinase activity
AFR_RS34300	COG1733	regulation of RNA biosynthetic process
AFR_RS34315	COG4977	sequence-specific DNA binding
AFR_RS34345	COG1501	Belongs to the glycosyl hydrolase 31 family
AFR_RS34350	COG1131	(ABC) transporter
AFR_RS34365	COG2197	response regulator
AFR_RS34380	COG4585	Histidine kinase
AFR_RS34385	COG2197	response regulator
AFR_RS34420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AFR_RS34425	COG0439	Biotin carboxylase
AFR_RS34470	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFR_RS34470	COG0515	serine threonine protein kinase
AFR_RS34515	COG1802	Transcriptional regulator
AFR_RS34545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFR_RS34555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFR_RS34570	COG2207	Transcriptional regulator
AFR_RS34575	COG0667	Aldo Keto reductase
AFR_RS34585	COG3118	belongs to the thioredoxin family
AFR_RS34600	COG3706	GGDEF domain
AFR_RS34615	COG1136	(ABC) transporter
AFR_RS34615	COG0577	efflux transmembrane transporter activity
AFR_RS34620	COG1136	(ABC) transporter
AFR_RS34625	COG0789	Transcriptional regulator
AFR_RS34715	COG1404	Belongs to the peptidase S8 family
AFR_RS34725	COG5001	Diguanylate cyclase
AFR_RS34740	COG1116	anion transmembrane transporter activity
AFR_RS34745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_RS34755	COG0010	Belongs to the arginase family
AFR_RS34790	COG2197	response regulator
AFR_RS34805	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS34820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFR_RS34830	COG0483	inositol monophosphate 1-phosphatase activity
AFR_RS34835	COG0671	phosphoesterase, PA-phosphatase related
AFR_RS34865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFR_RS34875	COG0395	ABC-type sugar transport system, permease component
AFR_RS34880	COG1175	transmembrane transport
AFR_RS34890	COG4821	SIS domain
AFR_RS34895	COG1737	Transcriptional regulator
AFR_RS34910	COG0318	PFAM AMP-dependent synthetase and ligase
AFR_RS34925	COG1609	Transcriptional regulator
AFR_RS34930	COG1063	alcohol dehydrogenase
AFR_RS34955	COG0300	oxidoreductase activity
AFR_RS34965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AFR_RS34970	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AFR_RS34975	COG2080	2 iron, 2 sulfur cluster binding
AFR_RS34995	COG2264	protein methyltransferase activity
AFR_RS35000	COG1914	H( )-stimulated, divalent metal cation uptake system
AFR_RS35005	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AFR_RS35010	COG4336	lyase activity
AFR_RS35015	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AFR_RS35025	COG1984	allophanate hydrolase subunit 2
AFR_RS35030	COG2188	Transcriptional regulator
AFR_RS35095	COG0419	ATPase involved in DNA repair
AFR_RS35100	COG0420	3'-5' exonuclease activity
AFR_RS35135	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AFR_RS35140	COG0156	8-amino-7-oxononanoate synthase activity
AFR_RS35145	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AFR_RS35150	COG0456	acetyltransferase
AFR_RS35155	COG1253	flavin adenine dinucleotide binding
AFR_RS35165	COG1522	sequence-specific DNA binding
AFR_RS35165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFR_RS35175	COG1597	lipid kinase activity
AFR_RS35205	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AFR_RS35230	COG4221	oxidoreductase activity
AFR_RS35235	COG1793	dna ligase
AFR_RS35245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AFR_RS35260	COG0577	efflux transmembrane transporter activity
AFR_RS35260	COG1136	(ABC) transporter
AFR_RS35265	COG4585	Histidine kinase
AFR_RS35290	COG1793	dna ligase
AFR_RS35290	COG3285	dna ligase
AFR_RS35315	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AFR_RS35330	COG0655	NAD(P)H dehydrogenase (quinone) activity
AFR_RS35345	COG3253	May function as heme-dependent peroxidase
AFR_RS35350	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AFR_RS35355	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AFR_RS35365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFR_RS35370	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AFR_RS35380	COG0183	Belongs to the thiolase family
AFR_RS35385	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFR_RS35385	COG1024	Enoyl-CoA hydratase
AFR_RS35405	COG2205	protein histidine kinase activity
AFR_RS35410	COG0745	RESPONSE REGULATOR receiver
AFR_RS35430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AFR_RS35435	COG1301	dicarboxylic acid transport
AFR_RS35440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AFR_RS35445	COG0531	amino acid
AFR_RS35450	COG0569	domain protein
AFR_RS35475	COG0756	dUTP diphosphatase activity
AFR_RS35520	COG2860	membrane
AFR_RS35530	COG2313	pseudouridylate synthase activity
AFR_RS35555	COG2188	Transcriptional regulator
AFR_RS35585	COG1490	D-aminoacyl-tRNA deacylase activity
AFR_RS35605	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AFR_RS35640	COG0738	Major facilitator superfamily
AFR_RS35685	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFR_RS35690	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AFR_RS35700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AFR_RS35715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AFR_RS35730	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AFR_RS35735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AFR_RS35740	COG1196	nuclear chromosome segregation
AFR_RS35755	COG1733	regulation of RNA biosynthetic process
AFR_RS35760	COG0583	DNA-binding transcription factor activity
AFR_RS35765	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS35775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFR_RS35785	COG1126	abc transporter atp-binding protein
AFR_RS35790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFR_RS35795	COG0765	amino acid transport
AFR_RS35800	COG0765	amino acid transport
AFR_RS35815	COG1418	mRNA catabolic process
AFR_RS35830	COG2137	regulation of response to DNA damage stimulus
AFR_RS35835	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AFR_RS35850	COG1573	uracil-dna glycosylase
AFR_RS35885	COG4326	sporulation control protein
AFR_RS35905	COG0515	serine threonine protein kinase
AFR_RS35905	COG2815	serine threonine protein kinase
AFR_RS35920	COG1201	RNA secondary structure unwinding
AFR_RS35935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_RS35960	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFR_RS35970	COG1842	Phage shock protein A
AFR_RS35975	COG1396	sequence-specific DNA binding
AFR_RS35980	COG1546	Belongs to the CinA family
AFR_RS35980	COG1058	Belongs to the CinA family
AFR_RS35990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFR_RS36000	COG1674	ftsk spoiiie
AFR_RS36020	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AFR_RS36025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AFR_RS36035	COG3214	Protein conserved in bacteria
AFR_RS36050	COG0395	ABC-type sugar transport system, permease component
AFR_RS36075	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AFR_RS36085	COG0612	Peptidase, M16
AFR_RS36090	COG1185	polyribonucleotide nucleotidyltransferase activity
AFR_RS36095	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AFR_RS36105	COG2205	protein histidine kinase activity
AFR_RS36105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFR_RS36110	COG0745	RESPONSE REGULATOR receiver
AFR_RS36135	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AFR_RS36140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AFR_RS36155	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AFR_RS36170	COG0779	Required for maturation of 30S ribosomal subunits
AFR_RS36215	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AFR_RS36220	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AFR_RS36230	COG1012	belongs to the aldehyde dehydrogenase family
AFR_RS36270	COG4585	Histidine kinase
AFR_RS36275	COG2197	response regulator
AFR_RS36280	COG4152	abc transporter atp-binding protein
AFR_RS36285	COG1668	transmembrane transport
AFR_RS36290	COG1309	transcriptional regulator
AFR_RS36295	COG1511	domain protein
AFR_RS36300	COG1121	(ABC) transporter
AFR_RS36310	COG0456	acetyltransferase
AFR_RS36320	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AFR_RS36325	COG0750	zinc metalloprotease
AFR_RS36340	COG2409	Drug exporters of the RND superfamily
AFR_RS36355	COG2146	nitrite reductase [NAD(P)H] activity
AFR_RS36355	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AFR_RS36370	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AFR_RS36380	COG0233	cytoplasmic translational termination
AFR_RS36385	COG0528	UMP kinase activity
AFR_RS36390	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AFR_RS36395	COG0052	Belongs to the universal ribosomal protein uS2 family
AFR_RS36405	COG0792	nuclease activity
AFR_RS36430	COG2188	Transcriptional regulator
AFR_RS36445	COG4974	Belongs to the 'phage' integrase family
AFR_RS36450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AFR_RS36465	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AFR_RS36475	COG0681	Belongs to the peptidase S26 family
AFR_RS36480	COG0681	Belongs to the peptidase S26 family
AFR_RS36485	COG0335	large ribosomal subunit rRNA binding
AFR_RS36490	COG0336	Belongs to the RNA methyltransferase TrmD family
AFR_RS36495	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AFR_RS36500	COG1837	Belongs to the UPF0109 family
AFR_RS36505	COG0228	four-way junction DNA binding
AFR_RS36520	COG0442	prolyl-tRNA aminoacylation
AFR_RS36555	COG0438	transferase activity, transferring glycosyl groups
AFR_RS36565	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AFR_RS36565	COG2755	lipolytic protein G-D-S-L family
AFR_RS36580	COG0463	Glycosyl transferase, family 2
AFR_RS36585	COG3739	integral membrane protein
AFR_RS36590	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AFR_RS36620	COG2318	DinB family
AFR_RS36670	COG2340	Cysteine-rich secretory protein family
AFR_RS36690	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFR_RS36700	COG0571	ribonuclease III activity
AFR_RS36705	COG0416	fatty acid biosynthetic process
AFR_RS36710	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AFR_RS36725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AFR_RS36730	COG0742	ribosomal rna small subunit methyltransferase
AFR_RS36760	COG1461	Dihydroxyacetone kinase
AFR_RS36765	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AFR_RS36790	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFR_RS36805	COG1131	(ABC) transporter
AFR_RS36810	COG2188	Transcriptional regulator
AFR_RS36820	COG0626	cystathionine gamma-synthase activity
AFR_RS36825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AFR_RS36835	COG1920	GTP binding
AFR_RS36845	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AFR_RS36850	COG0494	nUDIX hydrolase
AFR_RS36850	COG0406	alpha-ribazole phosphatase activity
AFR_RS36860	COG0776	regulation of translation
AFR_RS36865	COG0066	3-isopropylmalate dehydratase activity
AFR_RS36895	COG0702	epimerase
AFR_RS36905	COG0179	Fumarylacetoacetate (FAA) hydrolase
AFR_RS36910	COG1476	TRANSCRIPTIONal
AFR_RS36920	COG1131	(ABC) transporter
AFR_RS36940	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AFR_RS36955	COG2205	protein histidine kinase activity
AFR_RS36960	COG0745	RESPONSE REGULATOR receiver
AFR_RS36965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFR_RS36970	COG2304	oxidoreductase activity
AFR_RS36980	COG0714	Associated with various cellular activities
AFR_RS36985	COG0612	Peptidase, M16
AFR_RS37020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFR_RS37040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AFR_RS37045	COG0473	3-isopropylmalate dehydrogenase activity
AFR_RS37055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFR_RS37075	COG0440	acetolactate synthase activity
AFR_RS37090	COG0129	dihydroxy-acid dehydratase activity
AFR_RS37100	COG0395	ABC-type sugar transport system, permease component
AFR_RS37105	COG1175	transmembrane transport
AFR_RS37115	COG1609	Transcriptional regulator
AFR_RS37125	COG5001	Diguanylate cyclase
AFR_RS37125	COG3706	GGDEF domain
AFR_RS37125	COG4251	negative regulation of phosphorylation
AFR_RS37125	COG2203	Gaf domain
AFR_RS37145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFR_RS37150	COG2133	pyrroloquinoline quinone binding
AFR_RS37160	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFR_RS37165	COG0154	amidase activity
AFR_RS37170	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFR_RS37185	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AFR_RS37205	COG0482	sulfurtransferase activity
AFR_RS37215	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AFR_RS37225	COG2149	membrane
AFR_RS37245	COG0443	Heat shock 70 kDa protein
AFR_RS37275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFR_RS37280	COG1119	ATPase activity
AFR_RS37305	COG1309	transcriptional regulator
AFR_RS37325	COG2902	Dehydrogenase
AFR_RS37335	COG0010	Belongs to the arginase family
AFR_RS37360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFR_RS37360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFR_RS37400	COG0183	Belongs to the thiolase family
AFR_RS37405	COG0346	lactoylglutathione lyase activity
AFR_RS37450	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AFR_RS37465	COG1674	ftsk spoiiie
AFR_RS37485	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFR_RS37515	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AFR_RS37525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AFR_RS37530	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AFR_RS37535	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AFR_RS37540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFR_RS37545	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AFR_RS37550	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFR_RS37555	COG0356	it plays a direct role in the translocation of protons across the membrane
AFR_RS37570	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AFR_RS37575	COG0702	epimerase
AFR_RS37580	COG0009	L-threonylcarbamoyladenylate synthase
AFR_RS37585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AFR_RS37595	COG2890	protein-(glutamine-N5) methyltransferase activity
AFR_RS37610	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AFR_RS37615	COG0254	rRNA binding
AFR_RS37635	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AFR_RS37645	COG0083	homoserine kinase activity
AFR_RS37660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFR_RS37665	COG1846	Transcriptional regulator
AFR_RS37670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AFR_RS37675	COG0460	homoserine dehydrogenase
AFR_RS37685	COG0018	arginyl-trna synthetase
AFR_RS37740	COG4221	oxidoreductase activity
AFR_RS37750	COG0318	PFAM AMP-dependent synthetase and ligase
AFR_RS37755	COG0492	ferredoxin-NADP+ reductase activity
AFR_RS37760	COG2986	histidine ammonia-lyase
AFR_RS37780	COG0475	glutathione-regulated potassium exporter activity
AFR_RS37785	COG0745	RESPONSE REGULATOR receiver
AFR_RS37790	COG5002	protein histidine kinase activity
AFR_RS37800	COG0515	serine threonine protein kinase
AFR_RS37800	COG2815	serine threonine protein kinase
AFR_RS37835	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AFR_RS37840	COG1733	regulation of RNA biosynthetic process
AFR_RS37845	COG1073	alpha beta
AFR_RS37855	COG4221	oxidoreductase activity
AFR_RS37860	COG0583	DNA-binding transcription factor activity
AFR_RS37870	COG0477	Major facilitator Superfamily
AFR_RS37875	COG1742	UPF0060 membrane protein
AFR_RS37900	COG0456	acetyltransferase
AFR_RS37930	COG1595	DNA-templated transcription, initiation
AFR_RS37945	COG0673	inositol 2-dehydrogenase activity
AFR_RS37965	COG1595	DNA-templated transcription, initiation
AFR_RS37970	COG0754	glutathionylspermidine amidase activity
AFR_RS38010	COG0586	Pfam SNARE associated Golgi protein
AFR_RS38015	COG3469	chitinase activity
AFR_RS38025	COG0706	membrane insertase activity
AFR_RS38035	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AFR_RS38045	COG0726	polysaccharide deacetylase
AFR_RS38055	COG0740	serine-type endopeptidase activity
AFR_RS38065	COG1834	amidinotransferase
AFR_RS38070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AFR_RS38080	COG2154	pterin-4-alpha-carbinolamine dehydratase
AFR_RS38110	COG3842	ATPase activity
AFR_RS38135	COG2205	protein histidine kinase activity
AFR_RS38140	COG0745	RESPONSE REGULATOR receiver
AFR_RS38155	COG1131	(ABC) transporter
AFR_RS38165	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFR_RS38165	COG0567	Dehydrogenase, E1 component
AFR_RS38185	COG1132	(ABC) transporter
AFR_RS38190	COG0280	phosphate acetyltransferase
AFR_RS38190	COG0857	belongs to the CobB CobQ family
AFR_RS38195	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AFR_RS38235	COG2172	sigma factor antagonist activity
AFR_RS38240	COG2188	Transcriptional regulator
AFR_RS38250	COG1597	lipid kinase activity
AFR_RS38265	COG0175	sulfate reduction
AFR_RS38290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AFR_RS38300	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AFR_RS38310	COG1595	DNA-templated transcription, initiation
AFR_RS38325	COG2135	peptidase activity
AFR_RS38330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AFR_RS38340	COG0483	inositol monophosphate 1-phosphatase activity
AFR_RS38360	COG2197	response regulator
AFR_RS38385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AFR_RS38450	COG2409	Drug exporters of the RND superfamily
AFR_RS38465	COG1357	PFAM Pentapeptide repeats (8 copies)
AFR_RS38485	COG4221	oxidoreductase activity
AFR_RS38505	COG1615	UPF0182 protein
AFR_RS38510	COG3480	Lon protease (S16) C-terminal proteolytic domain
AFR_RS38535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AFR_RS38580	COG5285	phytanoyl-CoA dioxygenase
AFR_RS38585	COG2816	NAD+ diphosphatase activity
AFR_RS38620	COG0726	polysaccharide deacetylase
AFR_RS38630	COG1959	2 iron, 2 sulfur cluster binding
AFR_RS38640	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AFR_RS38665	COG1278	Cold shock
AFR_RS38685	COG1609	Transcriptional regulator
AFR_RS38695	COG1611	Belongs to the LOG family
AFR_RS38700	COG1611	Belongs to the LOG family
AFR_RS38705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFR_RS38730	COG2171	N-acyltransferase activity
AFR_RS38775	COG0667	Aldo Keto reductase
AFR_RS38785	COG4221	oxidoreductase activity
AFR_RS38790	COG0640	Transcriptional regulator
AFR_RS38815	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AFR_RS38820	COG0121	glutamine amidotransferase
AFR_RS38825	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AFR_RS38830	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS38830	COG3347	Dehydrogenase
AFR_RS38915	COG0656	L-ascorbic acid biosynthetic process
AFR_RS38925	COG1404	Belongs to the peptidase S8 family
AFR_RS38960	COG0583	DNA-binding transcription factor activity
AFR_RS38980	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AFR_RS39020	COG1053	succinate dehydrogenase
AFR_RS39090	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS39100	COG1960	acyl-CoA dehydrogenase activity
AFR_RS39135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFR_RS39160	COG0463	Glycosyl transferase, family 2
AFR_RS39165	COG3483	tryptophan 2,3-dioxygenase activity
AFR_RS39170	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AFR_RS39185	COG1960	acyl-CoA dehydrogenase activity
AFR_RS39190	COG0318	PFAM AMP-dependent synthetase and ligase
AFR_RS39350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AFR_RS39370	COG0525	valine-tRNA ligase activity
AFR_RS39385	COG1322	Protein conserved in bacteria
AFR_RS39390	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AFR_RS39405	COG1570	exodeoxyribonuclease VII activity
AFR_RS39410	COG1722	exodeoxyribonuclease VII activity
AFR_RS39430	COG0705	Rhomboid family
AFR_RS39445	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AFR_RS39450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFR_RS39450	COG0561	phosphatase activity
AFR_RS39465	COG0644	oxidoreductase
AFR_RS39480	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AFR_RS39485	COG1595	DNA-templated transcription, initiation
AFR_RS39515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AFR_RS39550	COG0424	maF-like protein
AFR_RS39570	COG4770	biotin carboxylase activity
AFR_RS39585	COG1305	Transglutaminase-like
AFR_RS39640	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AFR_RS39640	COG1473	amidohydrolase
AFR_RS39645	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFR_RS39645	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFR_RS39650	COG0515	serine threonine protein kinase
AFR_RS39650	COG2815	serine threonine protein kinase
AFR_RS39655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFR_RS39670	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AFR_RS39680	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AFR_RS39685	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AFR_RS39690	COG1012	belongs to the aldehyde dehydrogenase family
AFR_RS39695	COG1012	belongs to the aldehyde dehydrogenase family
AFR_RS39725	COG2018	Roadblock/LC7 domain
AFR_RS39730	COG0642	Histidine kinase
AFR_RS39735	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AFR_RS39760	COG1079	Belongs to the binding-protein-dependent transport system permease family
AFR_RS39765	COG4603	Belongs to the binding-protein-dependent transport system permease family
AFR_RS39770	COG3845	ABC transporter
AFR_RS39775	COG1744	ABC transporter substrate-binding protein PnrA-like
AFR_RS39790	COG1309	transcriptional regulator
AFR_RS39810	COG0180	Tryptophanyl-tRNA synthetase
AFR_RS39820	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AFR_RS39830	COG0640	Transcriptional regulator
AFR_RS39845	COG3507	Belongs to the glycosyl hydrolase 43 family
AFR_RS39850	COG0395	ABC-type sugar transport system, permease component
AFR_RS39855	COG1175	transmembrane transport
AFR_RS39860	COG1653	transport
AFR_RS39870	COG1609	Transcriptional regulator
AFR_RS39885	COG1218	3'(2'),5'-bisphosphate nucleotidase
AFR_RS39890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AFR_RS39895	COG0193	aminoacyl-tRNA hydrolase activity
AFR_RS39900	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AFR_RS39910	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AFR_RS39940	COG0596	Alpha beta hydrolase
AFR_RS39960	COG1309	transcriptional regulator
AFR_RS39975	COG0488	(ABC) transporter
AFR_RS39980	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AFR_RS39990	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFR_RS40000	COG0084	hydrolase, TatD family'
AFR_RS40020	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFR_RS40060	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AFR_RS40095	COG0303	'Molybdopterin
AFR_RS40100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AFR_RS40110	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AFR_RS40160	COG2095	MarC family integral membrane protein
AFR_RS40165	COG0613	PHP domain protein
AFR_RS40185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFR_RS40205	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS40235	COG0384	phenazine biosynthesis protein PhzF
AFR_RS40240	COG2239	Acts as a magnesium transporter
AFR_RS40255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFR_RS40260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFR_RS40270	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AFR_RS40280	COG1024	Enoyl-CoA hydratase
AFR_RS40295	COG0519	Catalyzes the synthesis of GMP from XMP
AFR_RS40310	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFR_RS40315	COG0674	pyruvate-flavodoxin oxidoreductase activity
AFR_RS40315	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AFR_RS40320	COG1013	pyruvate-flavodoxin oxidoreductase activity
AFR_RS40325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AFR_RS40360	COG0113	porphobilinogen synthase activity
AFR_RS40365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AFR_RS40365	COG1648	precorrin-2 dehydrogenase activity
AFR_RS40370	COG0181	hydroxymethylbilane synthase activity
AFR_RS40375	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AFR_RS40380	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AFR_RS40395	COG0318	PFAM AMP-dependent synthetase and ligase
AFR_RS40400	COG1595	DNA-templated transcription, initiation
AFR_RS40425	COG0506	proline dehydrogenase activity
AFR_RS40435	COG1082	Xylose isomerase domain protein TIM barrel
AFR_RS40460	COG0300	oxidoreductase activity
AFR_RS40480	COG0588	phosphoglycerate mutase activity
AFR_RS40490	COG0835	chemotaxis
AFR_RS40500	COG2814	Major facilitator Superfamily
AFR_RS40510	COG0438	transferase activity, transferring glycosyl groups
AFR_RS40530	COG0745	RESPONSE REGULATOR receiver
AFR_RS40545	COG2205	protein histidine kinase activity
AFR_RS40565	COG0739	heme binding
AFR_RS40565	COG0741	lytic transglycosylase activity
AFR_RS40565	COG1196	nuclear chromosome segregation
AFR_RS40570	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AFR_RS40575	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AFR_RS40580	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AFR_RS40585	COG1256	bacterial-type flagellum assembly
AFR_RS40585	COG4786	Flagellar basal body rod
AFR_RS40595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AFR_RS40605	COG1516	flagellar protein fliS
AFR_RS40615	COG1815	bacterial-type flagellum-dependent cell motility
AFR_RS40625	COG1677	Flagellar hook-basal body complex protein FliE
AFR_RS40630	COG1766	The M ring may be actively involved in energy transduction
AFR_RS40635	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AFR_RS40645	COG1157	protein secretion by the type III secretion system
AFR_RS40655	COG0739	heme binding
AFR_RS40655	COG1196	nuclear chromosome segregation
AFR_RS40655	COG0741	lytic transglycosylase activity
AFR_RS40685	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AFR_RS40700	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AFR_RS40705	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AFR_RS40705	COG1776	CheC inhibitor of MCP methylation
AFR_RS40715	COG1338	Plays a role in the flagellum-specific transport system
AFR_RS40725	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFR_RS40730	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFR_RS40760	COG0745	RESPONSE REGULATOR receiver
AFR_RS40770	COG0745	RESPONSE REGULATOR receiver
AFR_RS40780	COG2201	protein-glutamate methylesterase activity
AFR_RS40790	COG0835	chemotaxis
AFR_RS40795	COG2198	Histidine kinase
AFR_RS40795	COG0643	Histidine kinase
AFR_RS40795	COG0784	Response regulator, receiver
AFR_RS40800	COG0745	RESPONSE REGULATOR receiver
AFR_RS40815	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AFR_RS40880	COG3246	L-lysine catabolic process to acetate
AFR_RS40885	COG0354	folic acid binding
AFR_RS40890	COG0735	belongs to the Fur family
AFR_RS40895	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AFR_RS40900	COG4044	May play a role in the intracellular transport of hydrophobic ligands
AFR_RS40930	COG2897	thiosulfate sulfurtransferase activity
AFR_RS40945	COG0745	RESPONSE REGULATOR receiver
AFR_RS40950	COG0456	acetyltransferase
AFR_RS40960	COG2814	Major facilitator Superfamily
AFR_RS40975	COG0581	inorganic phosphate transmembrane transporter activity
AFR_RS40980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AFR_RS40990	COG0673	inositol 2-dehydrogenase activity
AFR_RS40995	COG0306	phosphate transporter
AFR_RS41010	COG1595	DNA-templated transcription, initiation
AFR_RS41035	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AFR_RS41040	COG2339	peptidase activity
AFR_RS41045	COG4129	membrane
AFR_RS41065	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AFR_RS41085	COG0459	protein refolding
AFR_RS41100	COG0456	acetyltransferase
AFR_RS41105	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AFR_RS41110	COG1131	(ABC) transporter
AFR_RS41125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFR_RS41135	COG1131	(ABC) transporter
AFR_RS41180	COG2205	protein histidine kinase activity
AFR_RS41185	COG0745	RESPONSE REGULATOR receiver
AFR_RS41195	COG1215	transferase activity, transferring glycosyl groups
AFR_RS41215	COG1349	DNA-binding transcription factor activity
AFR_RS41290	COG3842	ATPase activity
AFR_RS41300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFR_RS41305	COG0215	cysteine-tRNA ligase activity
AFR_RS41320	COG0114	fumarate hydratase activity
AFR_RS41340	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AFR_RS41340	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AFR_RS41355	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AFR_RS41360	COG1714	RDD family
AFR_RS41370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFR_RS41375	COG0577	efflux transmembrane transporter activity
AFR_RS41380	COG1136	(ABC) transporter
AFR_RS41385	COG4585	Histidine kinase
AFR_RS41390	COG2197	response regulator
AFR_RS41440	COG1846	Transcriptional regulator
AFR_RS41440	COG1940	carbohydrate kinase activity
AFR_RS41455	COG0395	ABC-type sugar transport system, permease component
AFR_RS41460	COG1486	melibiose metabolic process
AFR_RS41480	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AFR_RS41485	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AFR_RS41510	COG1960	acyl-CoA dehydrogenase activity
AFR_RS41530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AFR_RS41535	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AFR_RS41545	COG0242	peptide deformylase activity
AFR_RS41550	COG3830	Belongs to the UPF0237 family
AFR_RS41555	COG1194	a g-specific adenine glycosylase
AFR_RS41575	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AFR_RS41580	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AFR_RS41590	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AFR_RS41600	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AFR_RS41615	COG0649	NAD binding
AFR_RS41635	COG1174	glycine betaine transport
AFR_RS41640	COG1174	glycine betaine transport
AFR_RS41645	COG1125	glycine betaine transport
AFR_RS41645	COG0517	IMP dehydrogenase activity
AFR_RS41675	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AFR_RS41680	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AFR_RS41710	COG1196	nuclear chromosome segregation
AFR_RS41710	COG0741	lytic transglycosylase activity
AFR_RS41710	COG0739	heme binding
AFR_RS41725	COG1674	ftsk spoiiie
AFR_RS41745	COG0302	gtp cyclohydrolase
AFR_RS41750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFR_RS41755	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AFR_RS41760	COG0037	tRNA processing
AFR_RS41770	COG2027	D-alanyl-D-alanine carboxypeptidase
AFR_RS41775	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AFR_RS41785	COG1674	ftsk spoiiie
AFR_RS41815	COG2843	Capsule synthesis protein
AFR_RS41825	COG0825	malonyl-CoA metabolic process
AFR_RS41865	COG0003	Pfam Anion-transporting ATPase
AFR_RS41875	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AFR_RS41880	COG1610	YqeY-like protein
AFR_RS41915	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AFR_RS41940	COG2203	Gaf domain
AFR_RS41940	COG0840	transmembrane signaling receptor activity
AFR_RS41965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFR_RS41985	COG4608	Belongs to the ABC transporter superfamily
AFR_RS41990	COG0444	Belongs to the ABC transporter superfamily
AFR_RS42000	COG0747	negative chemotaxis
AFR_RS42005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFR_RS42010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AFR_RS42015	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AFR_RS42075	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AFR_RS42100	COG0813	purine-nucleoside phosphorylase activity
AFR_RS42130	COG0287	Prephenate dehydrogenase
AFR_RS42135	COG2318	DinB family
AFR_RS42140	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AFR_RS42140	COG0235	Class ii aldolase
AFR_RS42145	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AFR_RS42145	COG1796	DNA polymerase
AFR_RS42160	COG0642	Histidine kinase
AFR_RS42205	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AFR_RS42250	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AFR_RS42310	COG2084	Dehydrogenase
AFR_RS42325	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AFR_RS42340	COG0737	Belongs to the 5'-nucleotidase family
AFR_RS42365	COG1131	(ABC) transporter
AFR_RS42370	COG1725	Transcriptional regulator
AFR_RS42420	COG0242	peptide deformylase activity
AFR_RS42440	COG1881	PFAM PEBP family protein
AFR_RS42445	COG5002	protein histidine kinase activity
AFR_RS42470	COG4941	Belongs to the sigma-70 factor family
AFR_RS42485	COG2329	Antibiotic biosynthesis monooxygenase
AFR_RS42530	COG3469	chitinase activity
AFR_RS42535	COG0604	alcohol dehydrogenase
AFR_RS42535	COG3321	synthase
AFR_RS42535	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_RS42555	COG0789	Transcriptional regulator
AFR_RS42560	COG3959	Transketolase, thiamine diphosphate binding domain
AFR_RS42565	COG3958	Transketolase
AFR_RS42580	COG0183	Belongs to the thiolase family
AFR_RS42595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AFR_RS42610	COG0598	Magnesium transport protein CorA
AFR_RS42615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFR_RS42625	COG0371	Dehydrogenase
AFR_RS42640	COG0438	transferase activity, transferring glycosyl groups
AFR_RS42645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFR_RS42650	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AFR_RS42655	COG3275	phosphorelay sensor kinase activity
AFR_RS42665	COG0745	RESPONSE REGULATOR receiver
AFR_RS42670	COG2205	protein histidine kinase activity
AFR_RS42685	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFR_RS42705	COG0180	Tryptophanyl-tRNA synthetase
AFR_RS42720	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFR_RS42725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFR_RS42735	COG1316	TRANSCRIPTIONal
AFR_RS42750	COG5002	protein histidine kinase activity
AFR_RS42805	COG1764	response to oxidative stress
AFR_RS42815	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AFR_RS42820	COG0561	phosphatase activity
AFR_RS42825	COG0561	phosphatase activity
AFR_RS42835	COG1834	amidinotransferase
AFR_RS42865	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AFR_RS42870	COG3540	Alkaline phosphatase
AFR_RS42890	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AFR_RS42900	COG1408	metallophosphoesterase
AFR_RS42955	COG0521	Mo-molybdopterin cofactor biosynthetic process
AFR_RS42955	COG0315	cyclic pyranopterin monophosphate synthase activity
AFR_RS42960	COG0315	cyclic pyranopterin monophosphate synthase activity
AFR_RS42965	COG4251	negative regulation of phosphorylation
AFR_RS42965	COG2203	Gaf domain
AFR_RS42965	COG5001	Diguanylate cyclase
AFR_RS42965	COG3706	GGDEF domain
AFR_RS43035	COG0305	Participates in initiation and elongation during chromosome replication
AFR_RS43045	COG0359	binds to the 23S rRNA
AFR_RS43050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AFR_RS43060	COG0360	Binds together with S18 to 16S ribosomal RNA
AFR_RS43085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AFR_RS43095	COG1695	Transcriptional regulator
AFR_RS43130	COG0617	tRNA 3'-terminal CCA addition
AFR_RS43145	COG0515	serine threonine protein kinase
AFR_RS43145	COG2815	serine threonine protein kinase
AFR_RS43150	COG1595	DNA-templated transcription, initiation
AFR_RS43160	COG0492	ferredoxin-NADP+ reductase activity
AFR_RS43165	COG3118	belongs to the thioredoxin family
AFR_RS43170	COG3409	Peptidoglycan-binding domain 1 protein
AFR_RS43170	COG0860	N-Acetylmuramoyl-L-alanine amidase
AFR_RS43180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFR_RS43185	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFR_RS43200	COG1192	Involved in chromosome partitioning
AFR_RS43205	COG0357	Ribosomal RNA small subunit methyltransferase G
AFR_RS43215	COG0706	membrane insertase activity
AFR_RS43220	COG0594	ribonuclease P activity
AFR_RS43225	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AFR_RS43250	COG0840	transmembrane signaling receptor activity
AFR_RS43255	COG0438	transferase activity, transferring glycosyl groups
AFR_RS43260	COG0438	transferase activity, transferring glycosyl groups
AFR_RS43380	COG2197	response regulator
AFR_RS43450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFR_RS43545	COG4251	negative regulation of phosphorylation
AFR_RS43585	COG2226	methyltransferase
AFR_RS43590	COG2264	protein methyltransferase activity
AFR_RS43600	COG2199	diguanylate cyclase activity
AFR_RS43600	COG2200	EAL domain
AFR_RS43600	COG3287	FIST C domain
AFR_RS43665	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AFR_RS43695	COG4251	negative regulation of phosphorylation
AFR_RS43720	COG0590	tRNA wobble adenosine to inosine editing
AFR_RS43775	COG2197	response regulator
AFR_RS43785	COG5001	Diguanylate cyclase
AFR_RS43830	COG1404	Belongs to the peptidase S8 family
AFR_RS43835	COG2197	response regulator
AFR_RS43865	COG4251	negative regulation of phosphorylation
AFR_RS43895	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AFR_RS43895	COG4124	Belongs to the glycosyl hydrolase 26 family
AFR_RS43950	COG0443	Heat shock 70 kDa protein
AFR_RS44065	COG4585	Histidine kinase
AFR_RS44115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFR_RS44125	COG4585	Histidine kinase
AFR_RS44135	COG0583	DNA-binding transcription factor activity
AFR_RS44180	COG0515	serine threonine protein kinase
AFR_RS44185	COG2226	methyltransferase
AFR_RS44215	COG0456	acetyltransferase
AFR_RS44225	COG4585	Histidine kinase
AFR_RS44235	COG5001	Diguanylate cyclase
AFR_RS44235	COG3300	MHYT domain
AFR_RS44245	COG0215	cysteine-tRNA ligase activity
AFR_RS44330	COG4585	Histidine kinase
AFR_RS44340	COG1678	Uncharacterized ACR, COG1678
AFR_RS44345	COG0438	transferase activity, transferring glycosyl groups
AFR_RS44360	COG3706	GGDEF domain
AFR_RS44375	COG4585	Histidine kinase