locus-tag	class	description
L083_RS00010	COG0592	DNA-directed DNA polymerase activity
L083_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
L083_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L083_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
L083_RS00035	COG0187	DNA topoisomerase II activity
L083_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L083_RS00075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L083_RS00120	COG1595	DNA-templated transcription, initiation
L083_RS00130	COG1131	(ABC) transporter
L083_RS00155	COG0439	Biotin carboxylase
L083_RS00160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L083_RS00165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L083_RS00170	COG1960	acyl-CoA dehydrogenase activity
L083_RS00180	COG1846	Transcriptional regulator
L083_RS00185	COG2353	YceI-like domain
L083_RS00225	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
L083_RS00240	COG1716	ATPase activity
L083_RS00240	COG1716	ATPase activity
L083_RS00245	COG1716	ATPase activity
L083_RS00260	COG0768	penicillin binding
L083_RS00265	COG0515	serine threonine protein kinase
L083_RS00270	COG2815	serine threonine protein kinase
L083_RS00270	COG0515	serine threonine protein kinase
L083_RS00280	COG2181	nitrate reductase activity
L083_RS00280	COG0247	lactate metabolic process
L083_RS00370	COG0717	Belongs to the dCTP deaminase family
L083_RS00385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L083_RS00390	COG2770	Histidine kinase
L083_RS00390	COG2208	phosphoserine phosphatase activity
L083_RS00400	COG1960	acyl-CoA dehydrogenase activity
L083_RS00405	COG2062	phosphohistidine phosphatase, SixA
L083_RS00415	COG0702	epimerase
L083_RS00445	COG0508	dehydrogenase complex catalyzes the overall conversion of
L083_RS00450	COG0022	dehydrogenase e1 component
L083_RS00485	COG0443	Heat shock 70 kDa protein
L083_RS00490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L083_RS00495	COG0484	heat shock protein binding
L083_RS00500	COG0789	Transcriptional regulator
L083_RS00510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L083_RS00510	COG0475	glutathione-regulated potassium exporter activity
L083_RS00525	COG0542	response to heat
L083_RS00545	COG0640	Transcriptional regulator
L083_RS00550	COG0586	Pfam SNARE associated Golgi protein
L083_RS00555	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L083_RS00600	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L083_RS00605	COG0151	Belongs to the GarS family
L083_RS00625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L083_RS00630	COG0583	DNA-binding transcription factor activity
L083_RS00640	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L083_RS00645	COG0047	phosphoribosylformylglycinamidine synthase activity
L083_RS00650	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L083_RS00675	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L083_RS00680	COG0641	radical SAM
L083_RS00690	COG0789	Transcriptional regulator
L083_RS00705	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L083_RS00720	COG2226	methyltransferase
L083_RS00725	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
L083_RS00745	COG2050	protein possibly involved in aromatic compounds catabolism
L083_RS00780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_RS00800	COG0582	viral genome integration into host DNA
L083_RS00825	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
L083_RS00835	COG0142	geranyltranstransferase activity
L083_RS00895	COG0277	FAD linked oxidase domain protein
L083_RS00915	COG1136	(ABC) transporter
L083_RS00920	COG2197	response regulator
L083_RS00925	COG4585	Histidine kinase
L083_RS00930	COG3831	ATPase activity
L083_RS00935	COG0714	Associated with various cellular activities
L083_RS00940	COG2425	protein containing a von Willebrand factor type A (vWA) domain
L083_RS00945	COG3552	Protein containing von Willebrand factor type A (VWA) domain
L083_RS00950	COG4715	Zinc finger, swim domain protein
L083_RS01025	COG3293	Transposase
L083_RS01110	COG2814	Major facilitator Superfamily
L083_RS01160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L083_RS01165	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS01175	COG0667	Aldo Keto reductase
L083_RS01185	COG0604	alcohol dehydrogenase
L083_RS01185	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS01185	COG3321	synthase
L083_RS01205	COG0442	prolyl-tRNA aminoacylation
L083_RS01220	COG1668	transmembrane transport
L083_RS01225	COG4152	abc transporter atp-binding protein
L083_RS01235	COG0515	serine threonine protein kinase
L083_RS01245	COG1454	alcohol dehydrogenase
L083_RS01250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L083_RS01290	COG2304	oxidoreductase activity
L083_RS01305	COG0714	Associated with various cellular activities
L083_RS01330	COG3511	phospholipase C
L083_RS01360	COG0745	RESPONSE REGULATOR receiver
L083_RS01365	COG2205	protein histidine kinase activity
L083_RS01365	COG2202	Pas domain
L083_RS01375	COG2172	sigma factor antagonist activity
L083_RS01380	COG1366	Belongs to the anti-sigma-factor antagonist family
L083_RS01385	COG1366	Belongs to the anti-sigma-factor antagonist family
L083_RS01395	COG1970	mechanosensitive ion channel activity
L083_RS01450	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L083_RS01455	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L083_RS01480	COG1309	transcriptional regulator
L083_RS01485	COG1366	Belongs to the anti-sigma-factor antagonist family
L083_RS01490	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L083_RS01495	COG0406	alpha-ribazole phosphatase activity
L083_RS01500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L083_RS01505	COG0785	Cytochrome C biogenesis protein
L083_RS01510	COG1333	cytochrome c biogenesis protein
L083_RS01515	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L083_RS01520	COG1733	regulation of RNA biosynthetic process
L083_RS01535	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
L083_RS01555	COG0163	prenyltransferase activity
L083_RS01565	COG1522	sequence-specific DNA binding
L083_RS01585	COG0513	Belongs to the DEAD box helicase family
L083_RS01880	COG4974	Belongs to the 'phage' integrase family
L083_RS01885	COG0791	NLP P60 protein
L083_RS01885	COG3883	PFAM NLP P60 protein
L083_RS01890	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
L083_RS01915	COG3973	AAA domain
L083_RS01930	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
L083_RS01945	COG0463	Glycosyl transferase, family 2
L083_RS01955	COG0667	Aldo Keto reductase
L083_RS01965	COG4279	zinc finger
L083_RS01970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L083_RS01975	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
L083_RS01980	COG2226	methyltransferase
L083_RS02000	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L083_RS02005	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L083_RS02010	COG0649	NAD binding
L083_RS02020	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L083_RS02025	COG1034	ATP synthesis coupled electron transport
L083_RS02030	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L083_RS02035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L083_RS02045	COG0713	ATP synthesis coupled electron transport
L083_RS02060	COG1007	ATP synthesis coupled electron transport
L083_RS02065	COG0142	geranyltranstransferase activity
L083_RS02075	COG1414	Transcriptional regulator
L083_RS02095	COG1950	PFAM Membrane protein of
L083_RS02130	COG0596	Alpha beta hydrolase
L083_RS02150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L083_RS02205	COG1111	helicase
L083_RS02205	COG1205	dead DEAH box helicase
L083_RS02210	COG1366	Belongs to the anti-sigma-factor antagonist family
L083_RS02220	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
L083_RS02235	COG1754	DNA topoisomerase type I activity
L083_RS02235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L083_RS02245	COG1309	transcriptional regulator
L083_RS02255	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L083_RS02260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L083_RS02285	COG1774	PSP1 C-terminal conserved region
L083_RS02305	COG1595	DNA-templated transcription, initiation
L083_RS02395	COG0693	protein deglycase activity
L083_RS02410	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
L083_RS02415	COG3285	dna ligase
L083_RS02415	COG1793	dna ligase
L083_RS02420	COG3285	dna ligase
L083_RS02420	COG1793	dna ligase
L083_RS02440	COG1061	Type III restriction enzyme res subunit
L083_RS02460	COG1278	Cold shock
L083_RS02465	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
L083_RS02470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L083_RS02475	COG2814	Major facilitator Superfamily
L083_RS02490	COG2252	PERMEase
L083_RS02495	COG1846	Transcriptional regulator
L083_RS02500	COG2814	Major facilitator Superfamily
L083_RS02505	COG2186	Transcriptional regulator
L083_RS02510	COG2807	transmembrane transport
L083_RS02530	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
L083_RS02540	COG0259	pyridoxamine-phosphate oxidase activity
L083_RS02550	COG2017	converts alpha-aldose to the beta-anomer
L083_RS02565	COG1960	acyl-CoA dehydrogenase activity
L083_RS02590	COG1121	(ABC) transporter
L083_RS02595	COG2197	response regulator
L083_RS02615	COG1216	Glycosyl transferase, family 2
L083_RS02620	COG3842	ATPase activity
L083_RS02665	COG1388	LysM domain
L083_RS02665	COG1134	teichoic acid transport
L083_RS02675	COG1309	transcriptional regulator
L083_RS02735	COG0477	Major facilitator Superfamily
L083_RS02775	COG1172	Belongs to the binding-protein-dependent transport system permease family
L083_RS02780	COG1172	Belongs to the binding-protein-dependent transport system permease family
L083_RS02785	COG1129	ABC transporter
L083_RS02870	COG1674	ftsk spoiiie
L083_RS02890	COG0464	growth
L083_RS02895	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L083_RS02905	COG3629	intracellular signal transduction
L083_RS02905	COG3903	Transcriptional regulator
L083_RS02915	COG2197	response regulator
L083_RS02940	COG0477	Major facilitator Superfamily
L083_RS02945	COG0745	RESPONSE REGULATOR receiver
L083_RS02955	COG1595	DNA-templated transcription, initiation
L083_RS02965	COG1131	(ABC) transporter
L083_RS02985	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
L083_RS03000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L083_RS03005	COG1086	Polysaccharide biosynthesis protein
L083_RS03035	COG0463	Glycosyl transferase, family 2
L083_RS03065	COG2409	Drug exporters of the RND superfamily
L083_RS03080	COG1216	Glycosyl transferase, family 2
L083_RS03090	COG2089	acid synthase
L083_RS03110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L083_RS03115	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L083_RS03140	COG2182	Extracellular solute-binding protein
L083_RS03150	COG0395	ABC-type sugar transport system, permease component
L083_RS03155	COG1063	alcohol dehydrogenase
L083_RS03175	COG2814	Major facilitator Superfamily
L083_RS03195	COG2119	membrane
L083_RS03205	COG0477	Major facilitator Superfamily
L083_RS03235	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L083_RS03235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L083_RS03245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L083_RS03250	COG1942	4-Oxalocrotonate Tautomerase
L083_RS03255	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS03265	COG1253	flavin adenine dinucleotide binding
L083_RS03290	COG2837	iron assimilation
L083_RS03345	COG0586	Pfam SNARE associated Golgi protein
L083_RS03355	COG3285	dna ligase
L083_RS03355	COG1793	dna ligase
L083_RS03365	COG1064	alcohol dehydrogenase
L083_RS03370	COG1309	transcriptional regulator
L083_RS03405	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS03410	COG0667	Aldo Keto reductase
L083_RS03425	COG5001	Diguanylate cyclase
L083_RS03435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L083_RS03490	COG2207	Transcriptional regulator
L083_RS03505	COG0247	lactate metabolic process
L083_RS03510	COG1139	Iron-sulfur cluster binding protein
L083_RS03515	COG1556	Lactate utilization protein
L083_RS03525	COG0667	Aldo Keto reductase
L083_RS03555	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L083_RS03565	COG3795	YCII-related domain
L083_RS03570	COG4941	Belongs to the sigma-70 factor family
L083_RS03575	COG1082	Xylose isomerase domain protein TIM barrel
L083_RS03580	COG0501	Belongs to the peptidase M48B family
L083_RS03585	COG0242	peptide deformylase activity
L083_RS03590	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L083_RS03595	COG2124	cytochrome p450
L083_RS03600	COG0009	L-threonylcarbamoyladenylate synthase
L083_RS03760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS03770	COG1309	transcriptional regulator
L083_RS03795	COG4251	negative regulation of phosphorylation
L083_RS03800	COG2205	protein histidine kinase activity
L083_RS03800	COG0784	Response regulator, receiver
L083_RS03835	COG2382	esterase
L083_RS03835	COG3507	Belongs to the glycosyl hydrolase 43 family
L083_RS03835	COG3693	PFAM glycoside hydrolase, family 10
L083_RS03845	COG1215	transferase activity, transferring glycosyl groups
L083_RS03850	COG0438	transferase activity, transferring glycosyl groups
L083_RS03900	COG0745	RESPONSE REGULATOR receiver
L083_RS03905	COG2200	EAL domain
L083_RS03905	COG3287	FIST C domain
L083_RS03905	COG2199	diguanylate cyclase activity
L083_RS03935	COG1175	transmembrane transport
L083_RS03970	COG0583	DNA-binding transcription factor activity
L083_RS03990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L083_RS03995	COG0402	S-adenosylhomocysteine deaminase activity
L083_RS04000	COG1414	Transcriptional regulator
L083_RS04025	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L083_RS04035	COG2205	protein histidine kinase activity
L083_RS04040	COG0745	RESPONSE REGULATOR receiver
L083_RS04045	COG2124	cytochrome p450
L083_RS04085	COG0745	RESPONSE REGULATOR receiver
L083_RS04090	COG4251	negative regulation of phosphorylation
L083_RS04095	COG0784	Response regulator, receiver
L083_RS04100	COG0483	inositol monophosphate 1-phosphatase activity
L083_RS04105	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS04120	COG0515	serine threonine protein kinase
L083_RS04120	COG2815	serine threonine protein kinase
L083_RS04125	COG0569	domain protein
L083_RS04130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L083_RS04145	COG3103	Sh3 type 3 domain protein
L083_RS04145	COG1388	LysM domain
L083_RS04145	COG0791	NLP P60 protein
L083_RS04150	COG1937	Protein conserved in bacteria
L083_RS04165	COG5398	heme oxygenase
L083_RS04175	COG0513	Belongs to the DEAD box helicase family
L083_RS04195	COG0596	Alpha beta hydrolase
L083_RS04230	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
L083_RS04235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L083_RS04260	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L083_RS04290	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L083_RS04300	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L083_RS04310	COG0713	ATP synthesis coupled electron transport
L083_RS04320	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L083_RS04325	COG1007	ATP synthesis coupled electron transport
L083_RS04330	COG0501	Belongs to the peptidase M48B family
L083_RS04350	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS04365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS04375	COG2258	MOSC domain
L083_RS04405	COG1666	GTP binding
L083_RS04415	COG3300	MHYT domain
L083_RS04415	COG5001	Diguanylate cyclase
L083_RS04430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L083_RS04435	COG2030	dehydratase
L083_RS04450	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L083_RS04460	COG0081	regulation of translation
L083_RS04470	COG0222	ribosome binding
L083_RS04475	COG0085	RNA polymerase activity
L083_RS04480	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L083_RS04495	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L083_RS04500	COG0049	tRNA binding
L083_RS04505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L083_RS04510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L083_RS04515	COG0051	transcription antitermination factor activity, RNA binding
L083_RS04520	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L083_RS04525	COG0088	Forms part of the polypeptide exit tunnel
L083_RS04535	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L083_RS04540	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L083_RS04545	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L083_RS04550	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L083_RS04555	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L083_RS04560	COG0255	Belongs to the universal ribosomal protein uL29 family
L083_RS04565	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L083_RS04570	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L083_RS04575	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L083_RS04580	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L083_RS04585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L083_RS04590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L083_RS04595	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L083_RS04600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
L083_RS04605	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L083_RS04610	COG1841	ribosomal large subunit assembly
L083_RS04615	COG0200	Binds to the 23S rRNA
L083_RS04625	COG0563	adenylate kinase activity
L083_RS04645	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L083_RS04650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L083_RS04655	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L083_RS04660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L083_RS04665	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L083_RS04675	COG0203	ribosomal protein L17
L083_RS04680	COG0101	tRNA pseudouridine synthase activity
L083_RS04700	COG2813	Specifically methylates the guanine in position
L083_RS04705	COG0488	(ABC) transporter
L083_RS04710	COG0352	thiamine-phosphate diphosphorylase activity
L083_RS04715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L083_RS04715	COG2022	thiamine diphosphate biosynthetic process
L083_RS04725	COG2022	thiamine diphosphate biosynthetic process
L083_RS04730	COG0352	thiamine-phosphate diphosphorylase activity
L083_RS04735	COG0351	phosphomethylpyrimidine kinase
L083_RS04740	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
L083_RS04765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L083_RS04780	COG2018	Roadblock/LC7 domain
L083_RS04800	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L083_RS04805	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L083_RS04810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L083_RS04825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L083_RS04840	COG0736	holo-[acyl-carrier-protein] synthase activity
L083_RS04850	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L083_RS04860	COG0802	atpase or kinase
L083_RS04865	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L083_RS04875	COG0456	acetyltransferase
L083_RS04880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L083_RS04890	COG1132	(ABC) transporter
L083_RS04895	COG1132	(ABC) transporter
L083_RS04920	COG4214	carbohydrate transport
L083_RS04935	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L083_RS04945	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L083_RS04950	COG0459	protein refolding
L083_RS04970	COG2197	response regulator
L083_RS05005	COG1316	TRANSCRIPTIONal
L083_RS05020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L083_RS05020	COG0519	Catalyzes the synthesis of GMP from XMP
L083_RS05030	COG1051	belongs to the nudix hydrolase family
L083_RS05035	COG0494	nUDIX hydrolase
L083_RS05040	COG1183	phosphatidylcholine synthase activity
L083_RS05045	COG0688	phosphatidylethanolamine metabolic process
L083_RS05070	COG0747	negative chemotaxis
L083_RS05075	COG0601	transmembrane transport
L083_RS05080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L083_RS05090	COG4608	Belongs to the ABC transporter superfamily
L083_RS05095	COG1605	Chorismate mutase
L083_RS05100	COG0737	Belongs to the 5'-nucleotidase family
L083_RS05100	COG1525	nuclease
L083_RS05100	COG4085	toxin activity
L083_RS05110	COG4942	peptidase
L083_RS05120	COG0739	heme binding
L083_RS05125	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L083_RS05130	COG0045	succinate-CoA ligase (ADP-forming) activity
L083_RS05155	COG0138	bifunctional purine biosynthesis protein purh
L083_RS05175	COG0538	isocitrate dehydrogenase activity
L083_RS05185	COG1349	DNA-binding transcription factor activity
L083_RS05200	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
L083_RS05240	COG0529	Catalyzes the synthesis of activated sulfate
L083_RS05285	COG1131	(ABC) transporter
L083_RS05295	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
L083_RS05305	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L083_RS05305	COG1024	Enoyl-CoA hydratase
L083_RS05340	COG0148	phosphopyruvate hydratase activity
L083_RS05355	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
L083_RS05395	COG0714	Associated with various cellular activities
L083_RS05410	COG1252	NADH dehydrogenase
L083_RS05435	COG0183	Belongs to the thiolase family
L083_RS05460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L083_RS05490	COG2326	polyphosphate kinase activity
L083_RS05495	COG1234	tRNA 3'-trailer cleavage
L083_RS05505	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L083_RS05525	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L083_RS05530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L083_RS05540	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L083_RS05555	COG1331	Highly conserved protein containing a thioredoxin domain
L083_RS05625	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L083_RS05640	COG1607	acyl-coa hydrolase
L083_RS05645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L083_RS05670	COG0662	Cupin 2, conserved barrel domain protein
L083_RS05670	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
L083_RS05680	COG0778	Nitroreductase
L083_RS05680	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
L083_RS05685	COG0391	Required for morphogenesis under gluconeogenic growth conditions
L083_RS05700	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
L083_RS05730	COG1012	belongs to the aldehyde dehydrogenase family
L083_RS05740	COG1012	belongs to the aldehyde dehydrogenase family
L083_RS05765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L083_RS05770	COG1663	tetraacyldisaccharide 4'-kinase activity
L083_RS05770	COG2835	tetraacyldisaccharide 4'-kinase activity
L083_RS05800	COG0745	RESPONSE REGULATOR receiver
L083_RS05805	COG5002	protein histidine kinase activity
L083_RS05805	COG5000	phosphorelay sensor kinase activity
L083_RS05820	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L083_RS05825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L083_RS05835	COG0653	protein targeting
L083_RS05850	COG1522	sequence-specific DNA binding
L083_RS05875	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
L083_RS05880	COG2884	Cell division ATP-binding protein ftsE
L083_RS05890	COG1196	nuclear chromosome segregation
L083_RS05890	COG0741	lytic transglycosylase activity
L083_RS05890	COG0739	heme binding
L083_RS05895	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L083_RS05925	COG0737	Belongs to the 5'-nucleotidase family
L083_RS05930	COG1678	Uncharacterized ACR, COG1678
L083_RS05945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS05950	COG1802	Transcriptional regulator
L083_RS05985	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L083_RS05995	COG1459	type II secretion system
L083_RS06005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L083_RS06010	COG4977	sequence-specific DNA binding
L083_RS06120	COG0778	Nitroreductase
L083_RS06140	COG1953	Uracil, thiamine, allantoin
L083_RS06170	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L083_RS06175	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
L083_RS06195	COG5002	protein histidine kinase activity
L083_RS06195	COG5001	Diguanylate cyclase
L083_RS06220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L083_RS06225	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
L083_RS06235	COG1793	dna ligase
L083_RS06235	COG3285	dna ligase
L083_RS06240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_RS06245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L083_RS06265	COG1335	isochorismatase
L083_RS06270	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L083_RS06275	COG2197	response regulator
L083_RS06290	COG0667	Aldo Keto reductase
L083_RS06315	COG1234	tRNA 3'-trailer cleavage
L083_RS06320	COG0438	transferase activity, transferring glycosyl groups
L083_RS06325	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
L083_RS06330	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L083_RS06345	COG4941	Belongs to the sigma-70 factor family
L083_RS06355	COG2986	histidine ammonia-lyase
L083_RS06360	COG1228	amidohydrolase
L083_RS06365	COG1228	amidohydrolase
L083_RS06370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L083_RS06375	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
L083_RS06390	COG3217	Mosc domain protein beta barrel domain protein
L083_RS06390	COG0633	Ferredoxin
L083_RS06465	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L083_RS06495	COG0477	Major facilitator Superfamily
L083_RS06525	COG2208	phosphoserine phosphatase activity
L083_RS06525	COG2172	sigma factor antagonist activity
L083_RS06525	COG1366	Belongs to the anti-sigma-factor antagonist family
L083_RS06575	COG1376	ErfK ybiS ycfS ynhG family protein
L083_RS06580	COG1376	ErfK ybiS ycfS ynhG family protein
L083_RS06600	COG0784	Response regulator, receiver
L083_RS06605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L083_RS06660	COG1522	sequence-specific DNA binding
L083_RS06680	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L083_RS06680	COG0456	acetyltransferase
L083_RS06705	COG0640	Transcriptional regulator
L083_RS06725	COG2124	cytochrome p450
L083_RS06775	COG3903	Transcriptional regulator
L083_RS06775	COG3629	intracellular signal transduction
L083_RS06785	COG2706	6-phosphogluconolactonase activity
L083_RS06795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L083_RS06815	COG2115	Belongs to the xylose isomerase family
L083_RS06820	COG1070	Carbohydrate kinase
L083_RS06825	COG2814	Major facilitator Superfamily
L083_RS06830	COG0366	Alpha amylase catalytic
L083_RS06835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L083_RS06865	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS06930	COG2197	response regulator
L083_RS06940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L083_RS06990	COG0629	single-stranded DNA binding
L083_RS06995	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
L083_RS07000	COG1492	cobalamin metabolic process
L083_RS07010	COG0501	Belongs to the peptidase M48B family
L083_RS07030	COG1793	dna ligase
L083_RS07045	COG1797	cobyrinic acid a,c-diamide synthase activity
L083_RS07065	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L083_RS07070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L083_RS07070	COG1648	precorrin-2 dehydrogenase activity
L083_RS07080	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L083_RS07125	COG0668	transmembrane transport
L083_RS07180	COG0698	ribose 5-phosphate isomerase
L083_RS07190	COG4552	Acetyltransferase involved in intracellular survival and related
L083_RS07220	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS07225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L083_RS07230	COG3903	Transcriptional regulator
L083_RS07230	COG3629	intracellular signal transduction
L083_RS07260	COG2226	methyltransferase
L083_RS07265	COG1181	Belongs to the D-alanine--D-alanine ligase family
L083_RS07280	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS07305	COG1250	3-hydroxyacyl-CoA dehydrogenase
L083_RS07320	COG1053	succinate dehydrogenase
L083_RS07320	COG3976	FMN-binding domain protein
L083_RS07335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L083_RS07340	COG3959	Transketolase, thiamine diphosphate binding domain
L083_RS07345	COG0673	inositol 2-dehydrogenase activity
L083_RS07380	COG0544	peptidyl-prolyl cis-trans isomerase activity
L083_RS07385	COG0740	serine-type endopeptidase activity
L083_RS07390	COG0740	serine-type endopeptidase activity
L083_RS07395	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L083_RS07430	COG0525	valine-tRNA ligase activity
L083_RS07435	COG0285	dihydrofolate synthase activity
L083_RS07450	COG0105	UTP biosynthetic process
L083_RS07465	COG3046	protein related to deoxyribodipyrimidine photolyase
L083_RS07475	COG0596	Alpha beta hydrolase
L083_RS07480	COG2208	phosphoserine phosphatase activity
L083_RS07480	COG1366	Belongs to the anti-sigma-factor antagonist family
L083_RS07480	COG2172	sigma factor antagonist activity
L083_RS07485	COG1366	Belongs to the anti-sigma-factor antagonist family
L083_RS07500	COG1530	ribonuclease E activity
L083_RS07510	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L083_RS07515	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L083_RS07520	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L083_RS07550	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L083_RS07555	COG0799	negative regulation of ribosome biogenesis
L083_RS07560	COG0406	alpha-ribazole phosphatase activity
L083_RS07570	COG1307	EDD domain protein, DegV family
L083_RS07580	COG1555	photosystem II stabilization
L083_RS07580	COG1596	polysaccharide export
L083_RS07585	COG2333	competence protein COMEC
L083_RS07585	COG0658	competence protein
L083_RS07600	COG1090	epimerase
L083_RS07620	COG0268	Binds directly to 16S ribosomal RNA
L083_RS07640	COG0481	GTPase activity
L083_RS07645	COG2261	transglycosylase associated protein
L083_RS07660	COG1024	Enoyl-CoA hydratase
L083_RS07675	COG1420	regulation of RNA biosynthetic process
L083_RS07680	COG0484	heat shock protein binding
L083_RS07690	COG2249	NAD(P)H dehydrogenase (quinone) activity
L083_RS07700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L083_RS07705	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L083_RS07710	COG1120	ATPase activity
L083_RS07725	COG1132	(ABC) transporter
L083_RS07760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L083_RS07770	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
L083_RS07795	COG0667	Aldo Keto reductase
L083_RS07805	COG3486	L-lysine 6-monooxygenase (NADPH) activity
L083_RS07810	COG3547	Transposase (IS116 IS110 IS902 family)
L083_RS07810	COG3547	Transposase (IS116 IS110 IS902 family)
L083_RS07825	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS07840	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L083_RS07860	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L083_RS07875	COG1381	Involved in DNA repair and RecF pathway recombination
L083_RS07880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L083_RS07915	COG2353	YceI-like domain
L083_RS07950	COG0596	Alpha beta hydrolase
L083_RS07975	COG1122	ATPase activity
L083_RS07980	COG4721	ABC-type cobalt transport system, permease component
L083_RS07985	COG0596	Alpha beta hydrolase
L083_RS08010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L083_RS08015	COG1121	(ABC) transporter
L083_RS08040	COG0423	glycine-tRNA ligase activity
L083_RS08050	COG5002	protein histidine kinase activity
L083_RS08080	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L083_RS08105	COG3608	succinylglutamate desuccinylase aspartoacylase
L083_RS08105	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
L083_RS08150	COG0232	Belongs to the dGTPase family. Type 2 subfamily
L083_RS08155	COG0358	DNA primase activity
L083_RS08175	COG0842	Transport permease protein
L083_RS08200	COG1129	ABC transporter
L083_RS08205	COG1172	Belongs to the binding-protein-dependent transport system permease family
L083_RS08270	COG0583	DNA-binding transcription factor activity
L083_RS08345	COG1396	sequence-specific DNA binding
L083_RS08365	COG1404	Belongs to the peptidase S8 family
L083_RS08365	COG4412	M6 family metalloprotease domain protein
L083_RS08420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L083_RS08445	COG1404	Belongs to the peptidase S8 family
L083_RS08500	COG0018	arginyl-trna synthetase
L083_RS08530	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
L083_RS08535	COG1268	BioY protein
L083_RS08550	COG0714	Associated with various cellular activities
L083_RS08590	COG0737	Belongs to the 5'-nucleotidase family
L083_RS08600	COG0515	serine threonine protein kinase
L083_RS08615	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L083_RS08635	COG3973	AAA domain
L083_RS08645	COG0288	reversible hydration of carbon dioxide
L083_RS08660	COG1472	Belongs to the glycosyl hydrolase 3 family
L083_RS08685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L083_RS08690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L083_RS08725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L083_RS08740	COG2814	Major facilitator Superfamily
L083_RS08750	COG0840	transmembrane signaling receptor activity
L083_RS08755	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
L083_RS08760	COG0432	Pfam Uncharacterised protein family UPF0047
L083_RS08795	COG3509	depolymerase
L083_RS08830	COG2197	response regulator
L083_RS08845	COG0492	ferredoxin-NADP+ reductase activity
L083_RS08870	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L083_RS08940	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
L083_RS08940	COG0235	Class ii aldolase
L083_RS08945	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L083_RS08965	COG2197	response regulator
L083_RS08970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L083_RS08980	COG0475	glutathione-regulated potassium exporter activity
L083_RS08985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L083_RS08990	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L083_RS08995	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L083_RS09000	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
L083_RS09005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L083_RS09025	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L083_RS09035	COG2226	methyltransferase
L083_RS09065	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS09065	COG0604	alcohol dehydrogenase
L083_RS09065	COG3321	synthase
L083_RS09075	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
L083_RS09080	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L083_RS09080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L083_RS09085	COG0174	glutamine synthetase
L083_RS09090	COG3766	membrane
L083_RS09095	COG0456	acetyltransferase
L083_RS09105	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L083_RS09135	COG1733	regulation of RNA biosynthetic process
L083_RS09155	COG2207	Transcriptional regulator
L083_RS09160	COG0667	Aldo Keto reductase
L083_RS09170	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L083_RS09175	COG0017	Asparaginyl-tRNA synthetase
L083_RS09185	COG0321	lipoyl(octanoyl) transferase activity
L083_RS09205	COG0508	dehydrogenase complex catalyzes the overall conversion of
L083_RS09210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L083_RS09220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L083_RS09225	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L083_RS09230	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
L083_RS09235	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L083_RS09245	COG1994	Peptidase M50
L083_RS09250	COG0667	Aldo Keto reductase
L083_RS09285	COG4555	ABC transporter
L083_RS09295	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L083_RS09310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L083_RS09315	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L083_RS09330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L083_RS09340	COG0425	Belongs to the sulfur carrier protein TusA family
L083_RS09345	COG1104	cysteine desulfurase activity
L083_RS09350	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L083_RS09365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L083_RS09385	COG2010	Cytochrome c
L083_RS09395	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L083_RS09415	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L083_RS09425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L083_RS09445	COG0501	Belongs to the peptidase M48B family
L083_RS09450	COG0438	transferase activity, transferring glycosyl groups
L083_RS09455	COG2274	protein secretion by the type I secretion system
L083_RS09475	COG2072	flavoprotein involved in K transport
L083_RS09485	COG1940	carbohydrate kinase activity
L083_RS09505	COG2197	response regulator
L083_RS09510	COG0431	NADPH-dependent FMN reductase
L083_RS09565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L083_RS09580	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
L083_RS09600	COG0454	-acetyltransferase
L083_RS09600	COG0456	acetyltransferase
L083_RS09630	COG1053	succinate dehydrogenase
L083_RS09635	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L083_RS09685	COG0142	geranyltranstransferase activity
L083_RS09710	COG0515	serine threonine protein kinase
L083_RS09710	COG2815	serine threonine protein kinase
L083_RS09715	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
L083_RS09730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L083_RS09790	COG0745	RESPONSE REGULATOR receiver
L083_RS09860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L083_RS09870	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L083_RS09895	COG0714	Associated with various cellular activities
L083_RS09900	COG0495	leucyl-tRNA aminoacylation
L083_RS09905	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L083_RS09910	COG3226	Transcriptional regulator
L083_RS09925	COG3442	glutamine amidotransferase
L083_RS09930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L083_RS09935	COG3103	Sh3 type 3 domain protein
L083_RS09935	COG1388	LysM domain
L083_RS09935	COG0791	NLP P60 protein
L083_RS09940	COG2001	Belongs to the MraZ family
L083_RS09945	COG0275	rRNA processing
L083_RS09960	COG0768	penicillin binding
L083_RS09975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L083_RS09985	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L083_RS09990	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L083_RS09995	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L083_RS10000	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L083_RS10005	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L083_RS10010	COG1799	cell septum assembly
L083_RS10020	COG3599	regulation of cell shape
L083_RS10035	COG3263	regulation of cellular component size
L083_RS10045	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L083_RS10065	COG0587	DNA-directed DNA polymerase activity
L083_RS10075	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L083_RS10080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L083_RS10085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L083_RS10090	COG0131	Imidazoleglycerol-phosphate dehydratase
L083_RS10095	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L083_RS10105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L083_RS10110	COG0107	imidazoleglycerol-phosphate synthase activity
L083_RS10115	COG2205	protein histidine kinase activity
L083_RS10120	COG0745	RESPONSE REGULATOR receiver
L083_RS10130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L083_RS10130	COG1017	nitric oxide dioxygenase activity
L083_RS10145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L083_RS10155	COG1022	Amp-dependent synthetase and ligase
L083_RS10170	COG2205	protein histidine kinase activity
L083_RS10175	COG0745	RESPONSE REGULATOR receiver
L083_RS10190	COG0531	amino acid
L083_RS10200	COG1132	(ABC) transporter
L083_RS10205	COG1132	(ABC) transporter
L083_RS10210	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L083_RS10235	COG0667	Aldo Keto reductase
L083_RS10270	COG0604	alcohol dehydrogenase
L083_RS10310	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L083_RS10315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L083_RS10325	COG0667	Aldo Keto reductase
L083_RS10340	COG0134	indole-3-glycerol-phosphate synthase activity
L083_RS10345	COG0133	tryptophan synthase activity
L083_RS10350	COG0159	tryptophan synthase activity
L083_RS10355	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L083_RS10370	COG0067	glutamate synthase
L083_RS10370	COG0070	glutamate synthase
L083_RS10370	COG0069	glutamate synthase activity
L083_RS10420	COG1946	Acyl-CoA thioesterase
L083_RS10475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L083_RS10480	COG0765	amino acid transport
L083_RS10485	COG1126	abc transporter atp-binding protein
L083_RS10515	COG2226	methyltransferase
L083_RS10520	COG0539	negative regulation of cytoplasmic translation
L083_RS10525	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L083_RS10525	COG0237	dephospho-CoA kinase activity
L083_RS10545	COG1217	gtp-binding protein TYPA
L083_RS10555	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L083_RS10560	COG0740	serine-type endopeptidase activity
L083_RS10565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L083_RS10575	COG1162	GTPase activity
L083_RS10585	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L083_RS10595	COG0322	excinuclease ABC activity
L083_RS10600	COG1660	Displays ATPase and GTPase activities
L083_RS10610	COG1481	regulation of sporulation
L083_RS10620	COG0583	DNA-binding transcription factor activity
L083_RS10625	COG2223	nitrite transmembrane transporter activity
L083_RS10635	COG1309	transcriptional regulator
L083_RS10640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L083_RS10645	COG0126	phosphoglycerate kinase activity
L083_RS10650	COG0149	triose-phosphate isomerase activity
L083_RS10655	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L083_RS10665	COG0456	acetyltransferase
L083_RS10685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_RS10720	COG0363	glucosamine-6-phosphate deaminase activity
L083_RS10735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L083_RS10745	COG0109	protoheme IX farnesyltransferase activity
L083_RS10775	COG0719	Fe-S assembly protein
L083_RS10785	COG0396	ATPase activity
L083_RS10790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L083_RS10795	COG0822	iron-sulfur transferase activity
L083_RS10800	COG2151	metal-sulfur cluster biosynthetic enzyme
L083_RS10805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L083_RS10850	COG0789	Transcriptional regulator
L083_RS10855	COG0659	secondary active sulfate transmembrane transporter activity
L083_RS10860	COG1132	(ABC) transporter
L083_RS10875	COG0488	(ABC) transporter
L083_RS10885	COG0748	coenzyme F420 binding
L083_RS10890	COG1309	transcriptional regulator
L083_RS10895	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS10905	COG3663	DNA glycosylase
L083_RS10915	COG3220	belongs to the UPF0276 family
L083_RS10925	COG1309	transcriptional regulator
L083_RS10960	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS10965	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L083_RS11030	COG0006	proline dipeptidase activity
L083_RS11075	COG0714	Associated with various cellular activities
L083_RS11090	COG2304	oxidoreductase activity
L083_RS11105	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L083_RS11115	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L083_RS11125	COG3226	Transcriptional regulator
L083_RS11140	COG1051	belongs to the nudix hydrolase family
L083_RS11190	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L083_RS11225	COG1012	belongs to the aldehyde dehydrogenase family
L083_RS11230	COG0506	proline dehydrogenase activity
L083_RS11255	COG1365	unkown
L083_RS11260	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L083_RS11270	COG1653	transport
L083_RS11275	COG1175	transmembrane transport
L083_RS11280	COG0395	ABC-type sugar transport system, permease component
L083_RS11315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_RS11330	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L083_RS11340	COG1846	Transcriptional regulator
L083_RS11350	COG0494	nUDIX hydrolase
L083_RS11355	COG2197	response regulator
L083_RS11360	COG4585	Histidine kinase
L083_RS11380	COG1309	transcriptional regulator
L083_RS11390	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L083_RS11400	COG1012	belongs to the aldehyde dehydrogenase family
L083_RS11410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L083_RS11440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L083_RS11445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L083_RS11475	COG2271	Major facilitator Superfamily
L083_RS11495	COG0477	Major facilitator Superfamily
L083_RS11500	COG3629	intracellular signal transduction
L083_RS11505	COG1597	lipid kinase activity
L083_RS11530	COG0318	PFAM AMP-dependent synthetase and ligase
L083_RS11560	COG1595	DNA-templated transcription, initiation
L083_RS11580	COG2409	Drug exporters of the RND superfamily
L083_RS11595	COG2267	carboxylic ester hydrolase activity
L083_RS11655	COG0667	Aldo Keto reductase
L083_RS11660	COG1609	Transcriptional regulator
L083_RS11705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L083_RS11730	COG0456	acetyltransferase
L083_RS11735	COG0436	Aminotransferase
L083_RS11755	COG0745	RESPONSE REGULATOR receiver
L083_RS11795	COG2208	phosphoserine phosphatase activity
L083_RS11795	COG2770	Histidine kinase
L083_RS11805	COG0671	phosphoesterase, PA-phosphatase related
L083_RS11840	COG1522	sequence-specific DNA binding
L083_RS11875	COG0714	Associated with various cellular activities
L083_RS11925	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS11930	COG1309	transcriptional regulator
L083_RS11940	COG3012	SEC-C Motif Domain Protein
L083_RS11955	COG1914	H( )-stimulated, divalent metal cation uptake system
L083_RS11960	COG3546	catalase activity
L083_RS11965	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
L083_RS11985	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L083_RS12005	COG3629	intracellular signal transduction
L083_RS12050	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS12065	COG0477	Major facilitator Superfamily
L083_RS12125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L083_RS12145	COG0738	Major facilitator superfamily
L083_RS12150	COG1349	DNA-binding transcription factor activity
L083_RS12200	COG2116	formate transmembrane transporter activity
L083_RS12275	COG3321	synthase
L083_RS12275	COG0604	alcohol dehydrogenase
L083_RS12290	COG1250	3-hydroxyacyl-CoA dehydrogenase
L083_RS12300	COG1960	acyl-CoA dehydrogenase activity
L083_RS12310	COG0604	alcohol dehydrogenase
L083_RS12310	COG3321	synthase
L083_RS12315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L083_RS12325	COG2409	Drug exporters of the RND superfamily
L083_RS12330	COG2226	methyltransferase
L083_RS12340	COG2197	response regulator
L083_RS12365	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS12400	COG5002	protein histidine kinase activity
L083_RS12425	COG0583	DNA-binding transcription factor activity
L083_RS12430	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS12440	COG4977	sequence-specific DNA binding
L083_RS12440	COG1917	Cupin 2, conserved barrel domain protein
L083_RS12445	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L083_RS12480	COG1309	transcriptional regulator
L083_RS12555	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L083_RS12570	COG1733	regulation of RNA biosynthetic process
L083_RS12600	COG1674	ftsk spoiiie
L083_RS12630	COG0259	pyridoxamine-phosphate oxidase activity
L083_RS12645	COG3415	Transposase
L083_RS12645	COG2801	Transposase and inactivated derivatives
L083_RS12690	COG2801	Transposase and inactivated derivatives
L083_RS12690	COG3415	Transposase
L083_RS12785	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
L083_RS12805	COG4733	cellulase activity
L083_RS12805	COG5297	Belongs to the glycosyl hydrolase family 6
L083_RS12810	COG3345	alpha-galactosidase
L083_RS12825	COG0395	ABC-type sugar transport system, permease component
L083_RS12830	COG1175	transmembrane transport
L083_RS12835	COG1653	transport
L083_RS12840	COG1940	carbohydrate kinase activity
L083_RS12850	COG1472	Belongs to the glycosyl hydrolase 3 family
L083_RS12870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS12885	COG1902	pentaerythritol trinitrate reductase activity
L083_RS12910	COG4974	Belongs to the 'phage' integrase family
L083_RS12975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L083_RS12980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L083_RS12995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L083_RS13015	COG0477	Major facilitator Superfamily
L083_RS13025	COG2226	methyltransferase
L083_RS13050	COG4221	oxidoreductase activity
L083_RS13065	COG0702	epimerase
L083_RS13095	COG0395	ABC-type sugar transport system, permease component
L083_RS13110	COG1609	Transcriptional regulator
L083_RS13120	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L083_RS13150	COG0702	epimerase
L083_RS13180	COG4122	O-methyltransferase activity
L083_RS13195	COG3629	intracellular signal transduction
L083_RS13240	COG0745	RESPONSE REGULATOR receiver
L083_RS13245	COG2205	protein histidine kinase activity
L083_RS13260	COG2755	lipolytic protein G-D-S-L family
L083_RS13270	COG1595	DNA-templated transcription, initiation
L083_RS13275	COG2267	carboxylic ester hydrolase activity
L083_RS13280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L083_RS13320	COG0300	oxidoreductase activity
L083_RS13330	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS13340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L083_RS13345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L083_RS13350	COG4221	oxidoreductase activity
L083_RS13365	COG0444	Belongs to the ABC transporter superfamily
L083_RS13370	COG4172	Belongs to the ABC transporter superfamily
L083_RS13375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L083_RS13380	COG0601	transmembrane transport
L083_RS13430	COG1472	Belongs to the glycosyl hydrolase 3 family
L083_RS13445	COG0025	NhaP-type Na H and K H
L083_RS13460	COG3387	PFAM Glycoside hydrolase 15-related
L083_RS13465	COG1063	alcohol dehydrogenase
L083_RS13470	COG1252	NADH dehydrogenase
L083_RS13475	COG0243	molybdopterin cofactor binding
L083_RS13550	COG1960	acyl-CoA dehydrogenase activity
L083_RS13570	COG0596	Alpha beta hydrolase
L083_RS13600	COG2205	protein histidine kinase activity
L083_RS13605	COG0745	RESPONSE REGULATOR receiver
L083_RS13615	COG1136	(ABC) transporter
L083_RS13620	COG0577	efflux transmembrane transporter activity
L083_RS13620	COG1136	(ABC) transporter
L083_RS13635	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS13645	COG0114	fumarate hydratase activity
L083_RS13655	COG4221	oxidoreductase activity
L083_RS13680	COG1086	Polysaccharide biosynthesis protein
L083_RS13685	COG0489	protein tyrosine kinase activity
L083_RS13765	COG0583	DNA-binding transcription factor activity
L083_RS13770	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS13780	COG3548	integral membrane protein
L083_RS13785	COG0604	alcohol dehydrogenase
L083_RS13805	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS13830	COG0492	ferredoxin-NADP+ reductase activity
L083_RS13840	COG2197	response regulator
L083_RS13845	COG4585	Histidine kinase
L083_RS13875	COG2201	protein-glutamate methylesterase activity
L083_RS13905	COG0745	RESPONSE REGULATOR receiver
L083_RS13910	COG2205	protein histidine kinase activity
L083_RS13935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L083_RS13940	COG0366	Alpha amylase catalytic
L083_RS13945	COG0667	Aldo Keto reductase
L083_RS13950	COG0438	transferase activity, transferring glycosyl groups
L083_RS13990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L083_RS13995	COG0318	PFAM AMP-dependent synthetase and ligase
L083_RS14065	COG2409	Drug exporters of the RND superfamily
L083_RS14075	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L083_RS14080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_RS14085	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L083_RS14100	COG0546	phosphoglycolate phosphatase activity
L083_RS14120	COG3321	synthase
L083_RS14120	COG0604	alcohol dehydrogenase
L083_RS14160	COG0778	Nitroreductase
L083_RS14225	COG0745	RESPONSE REGULATOR receiver
L083_RS14230	COG5002	protein histidine kinase activity
L083_RS14230	COG5000	phosphorelay sensor kinase activity
L083_RS14280	COG0784	Response regulator, receiver
L083_RS14280	COG2205	protein histidine kinase activity
L083_RS14280	COG5002	protein histidine kinase activity
L083_RS14290	COG1063	alcohol dehydrogenase
L083_RS14320	COG2409	Drug exporters of the RND superfamily
L083_RS14360	COG0446	pyridine nucleotide-disulphide oxidoreductase
L083_RS14380	COG3345	alpha-galactosidase
L083_RS14395	COG2226	methyltransferase
L083_RS14400	COG2226	methyltransferase
L083_RS14430	COG0604	alcohol dehydrogenase
L083_RS14430	COG3321	synthase
L083_RS14435	COG3321	synthase
L083_RS14435	COG0604	alcohol dehydrogenase
L083_RS14455	COG0251	oxidation-reduction process
L083_RS14460	COG2423	ornithine cyclodeaminase activity
L083_RS14465	COG1181	Belongs to the D-alanine--D-alanine ligase family
L083_RS14480	COG0602	queuosine metabolic process
L083_RS14485	COG0720	synthase
L083_RS14490	COG0302	gtp cyclohydrolase
L083_RS14500	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L083_RS14570	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L083_RS14575	COG2197	response regulator
L083_RS14585	COG2267	carboxylic ester hydrolase activity
L083_RS14600	COG0604	alcohol dehydrogenase
L083_RS14600	COG3321	synthase
L083_RS14605	COG3321	synthase
L083_RS14605	COG0604	alcohol dehydrogenase
L083_RS14610	COG3321	synthase
L083_RS14610	COG0604	alcohol dehydrogenase
L083_RS14620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L083_RS14635	COG2264	protein methyltransferase activity
L083_RS14640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS14645	COG0745	RESPONSE REGULATOR receiver
L083_RS14650	COG5002	protein histidine kinase activity
L083_RS14735	COG2084	Dehydrogenase
L083_RS14760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L083_RS14765	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L083_RS14770	COG2226	methyltransferase
L083_RS14775	COG5002	protein histidine kinase activity
L083_RS14775	COG3850	Histidine kinase
L083_RS14785	COG3321	synthase
L083_RS14785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L083_RS14785	COG0604	alcohol dehydrogenase
L083_RS14785	COG4221	oxidoreductase activity
L083_RS14815	COG2018	Roadblock/LC7 domain
L083_RS14860	COG2197	response regulator
L083_RS14870	COG1960	acyl-CoA dehydrogenase activity
L083_RS14885	COG0438	transferase activity, transferring glycosyl groups
L083_RS14910	COG1136	(ABC) transporter
L083_RS14910	COG4591	ABC-type transport system involved in lipoprotein release permease component
L083_RS14915	COG1136	(ABC) transporter
L083_RS14915	COG4591	ABC-type transport system involved in lipoprotein release permease component
L083_RS14930	COG5520	Belongs to the glycosyl hydrolase 30 family
L083_RS14950	COG1309	transcriptional regulator
L083_RS14955	COG4221	oxidoreductase activity
L083_RS14960	COG0179	Fumarylacetoacetate (FAA) hydrolase
L083_RS14975	COG0129	dihydroxy-acid dehydratase activity
L083_RS14980	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS15005	COG0300	oxidoreductase activity
L083_RS15015	COG3485	protocatechuate 3,4-dioxygenase
L083_RS15020	COG3485	protocatechuate 3,4-dioxygenase
L083_RS15025	COG1414	Transcriptional regulator
L083_RS15040	COG0477	Major facilitator Superfamily
L083_RS15080	COG0439	Biotin carboxylase
L083_RS15085	COG0511	ligase activity, forming carbon-carbon bonds
L083_RS15090	COG0825	malonyl-CoA metabolic process
L083_RS15090	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L083_RS15120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L083_RS15125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L083_RS15155	COG2124	cytochrome p450
L083_RS15185	COG0367	asparagine synthase
L083_RS15190	COG1819	glycosyl
L083_RS15195	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L083_RS15205	COG1819	glycosyl
L083_RS15220	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS15230	COG2084	Dehydrogenase
L083_RS15235	COG2345	Transcriptional regulator
L083_RS15250	COG3104	oligopeptide transport
L083_RS15255	COG3629	intracellular signal transduction
L083_RS15255	COG3903	Transcriptional regulator
L083_RS15260	COG2133	pyrroloquinoline quinone binding
L083_RS15270	COG2197	response regulator
L083_RS15275	COG4585	Histidine kinase
L083_RS15280	COG0577	efflux transmembrane transporter activity
L083_RS15280	COG1136	(ABC) transporter
L083_RS15285	COG0577	efflux transmembrane transporter activity
L083_RS15305	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L083_RS15315	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
L083_RS15355	COG3629	intracellular signal transduction
L083_RS15355	COG3903	Transcriptional regulator
L083_RS15375	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS15400	COG0683	leucine binding
L083_RS15480	COG3509	depolymerase
L083_RS15490	COG1175	transmembrane transport
L083_RS15495	COG0395	ABC-type sugar transport system, permease component
L083_RS15560	COG0596	Alpha beta hydrolase
L083_RS15565	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
L083_RS15575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_RS15630	COG2124	cytochrome p450
L083_RS15640	COG2207	Transcriptional regulator
L083_RS15640	COG3708	Transcriptional regulator
L083_RS15645	COG1819	glycosyl
L083_RS15650	COG1819	glycosyl
L083_RS15655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L083_RS15675	COG2124	cytochrome p450
L083_RS15690	COG0367	asparagine synthase
L083_RS15695	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L083_RS15705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS15715	COG4941	Belongs to the sigma-70 factor family
L083_RS15740	COG0778	Nitroreductase
L083_RS15780	COG1733	regulation of RNA biosynthetic process
L083_RS15790	COG2205	protein histidine kinase activity
L083_RS15795	COG0745	RESPONSE REGULATOR receiver
L083_RS15835	COG0366	Alpha amylase catalytic
L083_RS15835	COG1470	cell adhesion involved in biofilm formation
L083_RS15855	COG1090	epimerase
L083_RS15860	COG4213	ABC transporter substrate-binding protein
L083_RS15870	COG4214	carbohydrate transport
L083_RS15875	COG3345	alpha-galactosidase
L083_RS15880	COG3509	depolymerase
L083_RS15910	COG1404	Belongs to the peptidase S8 family
L083_RS15915	COG3693	PFAM glycoside hydrolase, family 10
L083_RS15950	COG2267	carboxylic ester hydrolase activity
L083_RS15970	COG3458	cephalosporin-C deacetylase activity
L083_RS15980	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS15985	COG1959	2 iron, 2 sulfur cluster binding
L083_RS15995	COG0386	Belongs to the glutathione peroxidase family
L083_RS16000	COG3537	Alpha-1,2-mannosidase
L083_RS16005	COG0477	Major facilitator Superfamily
L083_RS16025	COG1672	PFAM Archaeal ATPase
L083_RS16025	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L083_RS16035	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS16050	COG1672	PFAM Archaeal ATPase
L083_RS16050	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L083_RS16080	COG0596	Alpha beta hydrolase
L083_RS16105	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
L083_RS16115	COG0701	Predicted permease
L083_RS16125	COG0601	transmembrane transport
L083_RS16130	COG0444	Belongs to the ABC transporter superfamily
L083_RS16145	COG2508	Transcriptional regulator
L083_RS16145	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L083_RS16165	COG4948	Mandelate Racemase Muconate Lactonizing
L083_RS16220	COG0604	alcohol dehydrogenase
L083_RS16230	COG0583	DNA-binding transcription factor activity
L083_RS16235	COG2080	2 iron, 2 sulfur cluster binding
L083_RS16240	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L083_RS16245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L083_RS16300	COG0745	RESPONSE REGULATOR receiver
L083_RS16305	COG2205	protein histidine kinase activity
L083_RS16355	COG5002	protein histidine kinase activity
L083_RS16365	COG1064	alcohol dehydrogenase
L083_RS16370	COG1376	ErfK ybiS ycfS ynhG family protein
L083_RS16435	COG3845	ABC transporter
L083_RS16440	COG4603	Belongs to the binding-protein-dependent transport system permease family
L083_RS16455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_RS16480	COG2807	transmembrane transport
L083_RS16530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L083_RS16540	COG0745	RESPONSE REGULATOR receiver
L083_RS16545	COG2205	protein histidine kinase activity
L083_RS16580	COG0588	phosphoglycerate mutase activity
L083_RS16585	COG3409	Peptidoglycan-binding domain 1 protein
L083_RS16585	COG3757	hydrolase, family 25
L083_RS16605	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
L083_RS16650	COG2239	Acts as a magnesium transporter
L083_RS16670	COG4109	DRTGG domain
L083_RS16725	COG1012	belongs to the aldehyde dehydrogenase family
L083_RS16725	COG1454	alcohol dehydrogenase
L083_RS16730	COG0589	response to stress
L083_RS16740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L083_RS16745	COG0617	tRNA 3'-terminal CCA addition
L083_RS16745	COG0517	IMP dehydrogenase activity
L083_RS16745	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L083_RS16765	COG2201	protein-glutamate methylesterase activity
L083_RS16830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L083_RS16835	COG1882	Formate acetyltransferase
L083_RS16845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L083_RS16845	COG0574	Belongs to the PEP-utilizing enzyme family
L083_RS16850	COG2239	Acts as a magnesium transporter
L083_RS16860	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
L083_RS16875	COG0494	nUDIX hydrolase
L083_RS16890	COG3537	Alpha-1,2-mannosidase
L083_RS16895	COG2837	iron assimilation
L083_RS16915	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L083_RS16925	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
L083_RS16945	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
L083_RS16955	COG0477	Major facilitator Superfamily
L083_RS16965	COG1733	regulation of RNA biosynthetic process
L083_RS16975	COG4221	oxidoreductase activity
L083_RS16980	COG1309	transcriptional regulator
L083_RS16985	COG0667	Aldo Keto reductase
L083_RS17050	COG0028	Belongs to the TPP enzyme family
L083_RS17055	COG0248	Ppx GppA phosphatase
L083_RS17090	COG1609	Transcriptional regulator
L083_RS17110	COG1785	Belongs to the alkaline phosphatase family
L083_RS17185	COG2837	iron assimilation
L083_RS17200	COG0803	Belongs to the bacterial solute-binding protein 9 family
L083_RS17205	COG1121	(ABC) transporter
L083_RS17210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L083_RS17225	COG1914	H( )-stimulated, divalent metal cation uptake system
L083_RS17235	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
L083_RS17280	COG0477	Major facilitator Superfamily
L083_RS17300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L083_RS17335	COG2367	Beta-lactamase
L083_RS17340	COG0706	membrane insertase activity
L083_RS17370	COG0531	amino acid
L083_RS17385	COG1215	transferase activity, transferring glycosyl groups
L083_RS17395	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L083_RS17400	COG1024	Enoyl-CoA hydratase
L083_RS17455	COG2356	endonuclease I
L083_RS17465	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
L083_RS17475	COG3119	arylsulfatase activity
L083_RS17480	COG0823	Involved in the tonB-independent uptake of proteins
L083_RS17490	COG0823	Involved in the tonB-independent uptake of proteins
L083_RS17490	COG1506	peptidase
L083_RS17495	COG3250	beta-galactosidase activity
L083_RS17555	COG2814	Major facilitator Superfamily
L083_RS17560	COG0395	ABC-type sugar transport system, permease component
L083_RS17565	COG1175	transmembrane transport
L083_RS17595	COG2986	histidine ammonia-lyase
L083_RS17610	COG0439	Biotin carboxylase
L083_RS17620	COG4221	oxidoreductase activity
L083_RS17625	COG2197	response regulator
L083_RS17630	COG0589	response to stress
L083_RS17650	COG3629	intracellular signal transduction
L083_RS17650	COG3903	Transcriptional regulator
L083_RS17665	COG0515	serine threonine protein kinase
L083_RS17675	COG1132	(ABC) transporter
L083_RS17680	COG1132	(ABC) transporter
L083_RS17685	COG2197	response regulator
L083_RS17690	COG2197	response regulator
L083_RS17695	COG1501	Belongs to the glycosyl hydrolase 31 family
L083_RS17700	COG1278	Cold shock
L083_RS17745	COG0297	glycogen (starch) synthase activity
L083_RS17755	COG1595	DNA-templated transcription, initiation
L083_RS17760	COG3537	Alpha-1,2-mannosidase
L083_RS17800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L083_RS17805	COG1063	alcohol dehydrogenase
L083_RS17835	COG1131	(ABC) transporter
L083_RS17850	COG2357	RelA SpoT domain protein
L083_RS17855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L083_RS17880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L083_RS17935	COG0726	polysaccharide deacetylase
L083_RS17945	COG2197	response regulator
L083_RS17980	COG2070	2-Nitropropane dioxygenase
L083_RS17985	COG1435	thymidine kinase activity
L083_RS18020	COG0740	serine-type endopeptidase activity
L083_RS18025	COG1396	sequence-specific DNA binding
L083_RS18030	COG1309	transcriptional regulator
L083_RS18070	COG2267	carboxylic ester hydrolase activity
L083_RS18075	COG2318	DinB family
L083_RS18090	COG3866	Pectate lyase
L083_RS18105	COG3629	intracellular signal transduction
L083_RS18105	COG3903	Transcriptional regulator
L083_RS18115	COG3386	PFAM SMP-30 Gluconolaconase
L083_RS18140	COG2201	protein-glutamate methylesterase activity
L083_RS18150	COG0583	DNA-binding transcription factor activity
L083_RS18155	COG0477	Major facilitator Superfamily
L083_RS18205	COG1609	Transcriptional regulator
L083_RS18230	COG4948	Mandelate Racemase Muconate Lactonizing
L083_RS18265	COG3409	Peptidoglycan-binding domain 1 protein
L083_RS18305	COG3940	Belongs to the glycosyl hydrolase 43 family
L083_RS18315	COG1609	Transcriptional regulator
L083_RS18320	COG1879	ABC-type sugar transport system periplasmic component
L083_RS18330	COG1172	Belongs to the binding-protein-dependent transport system permease family
L083_RS18335	COG1172	Belongs to the binding-protein-dependent transport system permease family
L083_RS18360	COG0673	inositol 2-dehydrogenase activity
L083_RS18365	COG0246	Mannitol dehydrogenase
L083_RS18370	COG4948	Mandelate Racemase Muconate Lactonizing
L083_RS18375	COG1904	glucuronate isomerase
L083_RS18380	COG0673	inositol 2-dehydrogenase activity
L083_RS18385	COG1609	Transcriptional regulator
L083_RS18395	COG1175	transmembrane transport
L083_RS18400	COG0395	ABC-type sugar transport system, permease component
L083_RS18420	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L083_RS18445	COG2133	pyrroloquinoline quinone binding
L083_RS18450	COG1802	Transcriptional regulator
L083_RS18455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L083_RS18470	COG2159	amidohydrolase
L083_RS18535	COG3022	response to hydroperoxide
L083_RS18570	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L083_RS18585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L083_RS18590	COG0431	NADPH-dependent FMN reductase
L083_RS18625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L083_RS18665	COG3383	formate dehydrogenase (NAD+) activity
L083_RS18665	COG0243	molybdopterin cofactor binding
L083_RS18670	COG0243	molybdopterin cofactor binding
L083_RS18670	COG3383	formate dehydrogenase (NAD+) activity
L083_RS18675	COG0437	4 iron, 4 sulfur cluster binding
L083_RS18685	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L083_RS18690	COG0596	Alpha beta hydrolase
L083_RS18705	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L083_RS18740	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L083_RS18800	COG2197	response regulator
L083_RS18805	COG4585	Histidine kinase
L083_RS18840	COG0701	Predicted permease
L083_RS18855	COG0477	Major facilitator Superfamily
L083_RS18865	COG1609	Transcriptional regulator
L083_RS18900	COG0789	Transcriptional regulator
L083_RS18940	COG1396	sequence-specific DNA binding
L083_RS18945	COG0745	RESPONSE REGULATOR receiver
L083_RS18965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L083_RS18970	COG1960	acyl-CoA dehydrogenase activity
L083_RS18980	COG0657	acetylesterase activity
L083_RS18980	COG2755	lipolytic protein G-D-S-L family
L083_RS18985	COG2764	glyoxalase bleomycin resistance protein dioxygenase
L083_RS19020	COG1509	lysine 2,3-aminomutase activity
L083_RS19025	COG0604	alcohol dehydrogenase
L083_RS19030	COG1574	metal-dependent hydrolase with the TIM-barrel fold
L083_RS19035	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
L083_RS19040	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L083_RS19045	COG1607	acyl-coa hydrolase
L083_RS19060	COG0463	Glycosyl transferase, family 2
L083_RS19145	COG1309	transcriptional regulator
L083_RS19180	COG0667	Aldo Keto reductase
L083_RS19190	COG4702	Belongs to the UPF0303 family
L083_RS19200	COG1846	Transcriptional regulator
L083_RS19205	COG1764	response to oxidative stress
L083_RS19210	COG2267	carboxylic ester hydrolase activity
L083_RS19230	COG1063	alcohol dehydrogenase
L083_RS19310	COG1968	undecaprenyl-diphosphatase activity
L083_RS19315	COG4974	Belongs to the 'phage' integrase family
L083_RS19325	COG1191	sigma factor activity
L083_RS19330	COG2197	response regulator
L083_RS19335	COG4585	Histidine kinase
L083_RS19345	COG1131	(ABC) transporter
L083_RS19365	COG0019	diaminopimelate decarboxylase activity
L083_RS19375	COG0242	peptide deformylase activity
L083_RS19395	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS19400	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L083_RS19400	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L083_RS19405	COG0667	Aldo Keto reductase
L083_RS19430	COG0667	Aldo Keto reductase
L083_RS19450	COG2272	Belongs to the type-B carboxylesterase lipase family
L083_RS19505	COG1716	ATPase activity
L083_RS19510	COG0509	glycine decarboxylation via glycine cleavage system
L083_RS19540	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
L083_RS19545	COG0384	phenazine biosynthesis protein PhzF
L083_RS19555	COG1649	PFAM Uncharacterised BCR, COG1649
L083_RS19565	COG0297	glycogen (starch) synthase activity
L083_RS19570	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L083_RS19625	COG2318	DinB family
L083_RS19690	COG3415	Transposase
L083_RS19690	COG2801	Transposase and inactivated derivatives
L083_RS19705	COG4585	Histidine kinase
L083_RS19710	COG2197	response regulator
L083_RS19720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS19745	COG4106	trans-aconitate 2-methyltransferase activity
L083_RS19760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L083_RS19770	COG0747	negative chemotaxis
L083_RS19790	COG4638	Rieske (2fe-2S)
L083_RS19795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L083_RS19810	COG4176	ABC-type proline glycine betaine transport system permease component
L083_RS19815	COG4175	Glycine betaine
L083_RS19815	COG0517	IMP dehydrogenase activity
L083_RS19880	COG1501	Belongs to the glycosyl hydrolase 31 family
L083_RS19900	COG1609	Transcriptional regulator
L083_RS19910	COG1472	Belongs to the glycosyl hydrolase 3 family
L083_RS19915	COG0515	serine threonine protein kinase
L083_RS19920	COG3201	nicotinamide mononucleotide transporter
L083_RS19945	COG0583	DNA-binding transcription factor activity
L083_RS19970	COG1215	transferase activity, transferring glycosyl groups
L083_RS19975	COG0438	transferase activity, transferring glycosyl groups
L083_RS20035	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
L083_RS20045	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L083_RS20060	COG2223	nitrite transmembrane transporter activity
L083_RS20065	COG2146	nitrite reductase [NAD(P)H] activity
L083_RS20070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L083_RS20075	COG0243	molybdopterin cofactor binding
L083_RS20105	COG0071	Belongs to the small heat shock protein (HSP20) family
L083_RS20125	COG0318	PFAM AMP-dependent synthetase and ligase
L083_RS20140	COG0500	methyltransferase
L083_RS20150	COG1609	Transcriptional regulator
L083_RS20155	COG0673	inositol 2-dehydrogenase activity
L083_RS20180	COG1309	transcriptional regulator
L083_RS20200	COG0667	Aldo Keto reductase
L083_RS20215	COG1177	transmembrane transport
L083_RS20220	COG3842	ATPase activity
L083_RS20230	COG2936	dipeptidyl-peptidase activity
L083_RS20280	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L083_RS20285	COG3842	ATPase activity
L083_RS20295	COG1176	ABC-type spermidine putrescine transport system, permease component I
L083_RS20300	COG1177	transmembrane transport
L083_RS20305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L083_RS20315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS20325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L083_RS20330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L083_RS20335	COG1522	sequence-specific DNA binding
L083_RS20365	COG1131	(ABC) transporter
L083_RS20385	COG1012	belongs to the aldehyde dehydrogenase family
L083_RS20395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS20400	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L083_RS20400	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L083_RS20425	COG0535	radical SAM domain protein
L083_RS20450	COG1131	(ABC) transporter
L083_RS20460	COG2197	response regulator
L083_RS20505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS20510	COG1472	Belongs to the glycosyl hydrolase 3 family
L083_RS20520	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
L083_RS20540	COG3706	GGDEF domain
L083_RS20575	COG3401	FG-GAP repeat protein
L083_RS20585	COG3608	succinylglutamate desuccinylase aspartoacylase
L083_RS20585	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
L083_RS20595	COG1802	Transcriptional regulator
L083_RS20605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L083_RS20610	COG1116	anion transmembrane transporter activity
L083_RS20635	COG1278	Cold shock
L083_RS20670	COG2226	methyltransferase
L083_RS20680	COG0346	lactoylglutathione lyase activity
L083_RS20710	COG1120	ATPase activity
L083_RS20730	COG0667	Aldo Keto reductase
L083_RS20760	COG3268	Saccharopine dehydrogenase
L083_RS20770	COG2154	pterin-4-alpha-carbinolamine dehydratase
L083_RS20795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L083_RS20800	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L083_RS20830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L083_RS20850	COG2409	Drug exporters of the RND superfamily
L083_RS20865	COG2267	carboxylic ester hydrolase activity
L083_RS20915	COG4213	ABC transporter substrate-binding protein
L083_RS20940	COG0438	transferase activity, transferring glycosyl groups
L083_RS20945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L083_RS20965	COG5001	Diguanylate cyclase
L083_RS20965	COG3300	MHYT domain
L083_RS20970	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
L083_RS20990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L083_RS21005	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
L083_RS21010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS21020	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L083_RS21045	COG4733	cellulase activity
L083_RS21045	COG5297	Belongs to the glycosyl hydrolase family 6
L083_RS21075	COG0395	ABC-type sugar transport system, permease component
L083_RS21085	COG1609	Transcriptional regulator
L083_RS21090	COG1652	LysM domain
L083_RS21100	COG4948	Mandelate Racemase Muconate Lactonizing
L083_RS21130	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L083_RS21150	COG0303	'Molybdopterin
L083_RS21155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_RS21180	COG2080	2 iron, 2 sulfur cluster binding
L083_RS21180	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L083_RS21185	COG0646	methionine synthase
L083_RS21185	COG1410	methionine synthase
L083_RS21190	COG0537	adenosine 5'-monophosphoramidase activity
L083_RS21195	COG2130	NADP-dependent
L083_RS21220	COG0326	Molecular chaperone. Has ATPase activity
L083_RS21230	COG2814	Major facilitator Superfamily
L083_RS21245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L083_RS21255	COG0583	DNA-binding transcription factor activity
L083_RS21275	COG1921	L-seryl-tRNASec selenium transferase activity
L083_RS21300	COG0709	Synthesizes selenophosphate from selenide and ATP
L083_RS21305	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L083_RS21325	COG0438	transferase activity, transferring glycosyl groups
L083_RS21350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L083_RS21365	COG0514	ATP-dependent DNA helicase (RecQ)
L083_RS21410	COG0604	alcohol dehydrogenase
L083_RS21415	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
L083_RS21420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L083_RS21455	COG0277	FAD linked oxidase domain protein
L083_RS21460	COG0277	FAD linked oxidase domain protein
L083_RS21465	COG0247	lactate metabolic process
L083_RS21495	COG2382	esterase
L083_RS21505	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L083_RS21520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_RS21535	COG5001	Diguanylate cyclase
L083_RS21535	COG3300	MHYT domain
L083_RS21545	COG0300	oxidoreductase activity
L083_RS21555	COG0310	cobalt ion transport
L083_RS21565	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L083_RS21570	COG1122	ATPase activity
L083_RS21590	COG1609	Transcriptional regulator
L083_RS21595	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L083_RS21595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L083_RS21620	COG0456	acetyltransferase
L083_RS21655	COG0242	peptide deformylase activity
L083_RS21700	COG1461	Dihydroxyacetone kinase
L083_RS21705	COG2376	Dihydroxyacetone kinase
L083_RS21720	COG1136	(ABC) transporter
L083_RS21725	COG1136	(ABC) transporter
L083_RS21770	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L083_RS21795	COG3104	oligopeptide transport
L083_RS21810	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
L083_RS21815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L083_RS21820	COG4251	negative regulation of phosphorylation
L083_RS21845	COG1012	belongs to the aldehyde dehydrogenase family
L083_RS21850	COG0574	Belongs to the PEP-utilizing enzyme family
L083_RS21850	COG3848	Pyruvate phosphate dikinase
L083_RS21865	COG0789	Transcriptional regulator
L083_RS21870	COG3903	Transcriptional regulator
L083_RS21870	COG3629	intracellular signal transduction
L083_RS21880	COG1309	transcriptional regulator
L083_RS21885	COG0477	Major facilitator Superfamily
L083_RS21900	COG1105	Belongs to the carbohydrate kinase PfkB family
L083_RS21935	COG1349	DNA-binding transcription factor activity
L083_RS21940	COG1486	melibiose metabolic process
L083_RS21945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L083_RS21950	COG2182	Extracellular solute-binding protein
L083_RS21955	COG1175	transmembrane transport
L083_RS21960	COG0395	ABC-type sugar transport system, permease component
L083_RS21975	COG3693	PFAM glycoside hydrolase, family 10
L083_RS21980	COG0442	prolyl-tRNA aminoacylation
L083_RS22000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L083_RS22070	COG0745	RESPONSE REGULATOR receiver
L083_RS22080	COG4221	oxidoreductase activity
L083_RS22115	COG2188	Transcriptional regulator
L083_RS22120	COG0159	tryptophan synthase activity
L083_RS22125	COG0133	tryptophan synthase activity
L083_RS22145	COG5002	protein histidine kinase activity
L083_RS22145	COG5001	Diguanylate cyclase
L083_RS22145	COG3447	MASE1 domain protein
L083_RS22150	COG3883	PFAM NLP P60 protein
L083_RS22150	COG0791	NLP P60 protein
L083_RS22155	COG0501	Belongs to the peptidase M48B family
L083_RS22165	COG1271	oxidase subunit
L083_RS22170	COG1294	oxidase, subunit
L083_RS22175	COG4988	ABC transporter
L083_RS22195	COG0859	PFAM glycosyl transferase family 9
L083_RS22200	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS22205	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L083_RS22205	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L083_RS22210	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L083_RS22215	COG0297	glycogen (starch) synthase activity
L083_RS22225	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L083_RS22235	COG2192	nodulation
L083_RS22250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS22270	COG0667	Aldo Keto reductase
L083_RS22280	COG0477	Major facilitator Superfamily
L083_RS22285	COG1309	transcriptional regulator
L083_RS22295	COG1132	(ABC) transporter
L083_RS22300	COG1132	(ABC) transporter
L083_RS22305	COG2207	Transcriptional regulator
L083_RS22305	COG3708	Transcriptional regulator
L083_RS22320	COG1609	Transcriptional regulator
L083_RS22335	COG0583	DNA-binding transcription factor activity
L083_RS22345	COG0527	aspartate kinase activity
L083_RS22350	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L083_RS22355	COG0697	spore germination
L083_RS22360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L083_RS22365	COG4865	methylaspartate mutase activity
L083_RS22370	COG0745	RESPONSE REGULATOR receiver
L083_RS22375	COG2205	protein histidine kinase activity
L083_RS22380	COG2409	Drug exporters of the RND superfamily
L083_RS22415	COG1175	transmembrane transport
L083_RS22470	COG1301	dicarboxylic acid transport
L083_RS22475	COG3290	protein histidine kinase activity
L083_RS22480	COG4565	transcriptional regulatory protein
L083_RS22490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L083_RS22505	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS22510	COG1309	transcriptional regulator
L083_RS22525	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
L083_RS22530	COG4988	ABC transporter
L083_RS22535	COG1294	oxidase, subunit
L083_RS22540	COG1271	oxidase subunit
L083_RS22545	COG0745	RESPONSE REGULATOR receiver
L083_RS22550	COG2205	protein histidine kinase activity
L083_RS22560	COG1653	transport
L083_RS22565	COG1175	transmembrane transport
L083_RS22570	COG0395	ABC-type sugar transport system, permease component
L083_RS22575	COG3973	AAA domain
L083_RS22580	COG0058	SHG alpha-glucan phosphorylase activity
L083_RS22610	COG5002	protein histidine kinase activity
L083_RS22615	COG4251	negative regulation of phosphorylation
L083_RS22635	COG4166	transmembrane transport
L083_RS22640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L083_RS22650	COG4172	Belongs to the ABC transporter superfamily
L083_RS22670	COG0515	serine threonine protein kinase
L083_RS22680	COG0730	response to heat
L083_RS22685	COG2175	clavaminate synthase activity
L083_RS22690	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L083_RS22695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L083_RS22700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L083_RS22710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L083_RS22715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L083_RS22735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L083_RS22780	COG1418	mRNA catabolic process
L083_RS22780	COG1193	negative regulation of DNA recombination
L083_RS22790	COG0531	amino acid
L083_RS22800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS22810	COG0745	RESPONSE REGULATOR receiver
L083_RS22830	COG0667	Aldo Keto reductase
L083_RS22840	COG0442	prolyl-tRNA aminoacylation
L083_RS22865	COG1957	nucleoside hydrolase
L083_RS22910	COG3321	synthase
L083_RS22910	COG0604	alcohol dehydrogenase
L083_RS22915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L083_RS22920	COG2151	metal-sulfur cluster biosynthetic enzyme
L083_RS22925	COG3396	Phenylacetate-CoA oxygenase
L083_RS22930	COG3460	Phenylacetate-CoA oxygenase
L083_RS22935	COG3396	Phenylacetate-CoA oxygenase
L083_RS22980	COG1131	(ABC) transporter
L083_RS22995	COG2197	response regulator
L083_RS23000	COG0673	inositol 2-dehydrogenase activity
L083_RS23030	COG3718	enzyme involved in inositol metabolism
L083_RS23035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L083_RS23045	COG3384	dioxygenase
L083_RS23100	COG1136	(ABC) transporter
L083_RS23100	COG0577	efflux transmembrane transporter activity
L083_RS23105	COG1136	(ABC) transporter
L083_RS23110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L083_RS23115	COG2205	protein histidine kinase activity
L083_RS23120	COG0745	RESPONSE REGULATOR receiver
L083_RS23140	COG2890	protein-(glutamine-N5) methyltransferase activity
L083_RS23145	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L083_RS23150	COG1620	l-lactate permease
L083_RS23155	COG3469	chitinase activity
L083_RS23175	COG2814	Major facilitator Superfamily
L083_RS23180	COG1940	carbohydrate kinase activity
L083_RS23185	COG0406	alpha-ribazole phosphatase activity
L083_RS23195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS23265	COG0166	Belongs to the GPI family
L083_RS23280	COG1063	alcohol dehydrogenase
L083_RS23330	COG2197	response regulator
L083_RS23375	COG1335	isochorismatase
L083_RS23420	COG3304	Inner membrane component domain
L083_RS23425	COG1247	-acetyltransferase
L083_RS23430	COG4279	zinc finger
L083_RS23435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L083_RS23450	COG1181	Belongs to the D-alanine--D-alanine ligase family
L083_RS23465	COG0531	amino acid
L083_RS23475	COG0515	serine threonine protein kinase
L083_RS23505	COG0463	Glycosyl transferase, family 2
L083_RS23535	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L083_RS23555	COG0456	acetyltransferase
L083_RS23600	COG1408	metallophosphoesterase
L083_RS23705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L083_RS23750	COG0395	ABC-type sugar transport system, permease component
L083_RS23765	COG2501	S4 domain
L083_RS23780	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L083_RS23795	COG1366	Belongs to the anti-sigma-factor antagonist family
L083_RS23860	COG4214	carbohydrate transport
L083_RS23865	COG1129	ABC transporter
L083_RS23870	COG4213	ABC transporter substrate-binding protein
L083_RS23875	COG2160	L-arabinose isomerase activity
L083_RS23885	COG1609	Transcriptional regulator
L083_RS23900	COG3940	Belongs to the glycosyl hydrolase 43 family
L083_RS23960	COG0577	efflux transmembrane transporter activity
L083_RS23960	COG1136	(ABC) transporter
L083_RS23985	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L083_RS23995	COG0840	transmembrane signaling receptor activity
L083_RS24000	COG0643	Histidine kinase
L083_RS24000	COG2198	Histidine kinase
L083_RS24005	COG2201	protein-glutamate methylesterase activity
L083_RS24015	COG0577	efflux transmembrane transporter activity
L083_RS24015	COG1136	(ABC) transporter
L083_RS24020	COG0577	efflux transmembrane transporter activity
L083_RS24020	COG1136	(ABC) transporter
L083_RS24025	COG4585	Histidine kinase
L083_RS24030	COG2197	response regulator
L083_RS24065	COG0463	Glycosyl transferase, family 2
L083_RS24090	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L083_RS24110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L083_RS24145	COG1960	acyl-CoA dehydrogenase activity
L083_RS24185	COG1309	transcriptional regulator
L083_RS24205	COG4106	trans-aconitate 2-methyltransferase activity
L083_RS24210	COG1064	alcohol dehydrogenase
L083_RS24220	COG3300	MHYT domain
L083_RS24220	COG5001	Diguanylate cyclase
L083_RS24225	COG3300	MHYT domain
L083_RS24225	COG5001	Diguanylate cyclase
L083_RS24230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L083_RS24255	COG2197	response regulator
L083_RS24260	COG4585	Histidine kinase
L083_RS24265	COG2409	Drug exporters of the RND superfamily
L083_RS24270	COG4677	pectinesterase activity
L083_RS24310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L083_RS24315	COG2030	dehydratase
L083_RS24360	COG0577	efflux transmembrane transporter activity
L083_RS24360	COG1136	(ABC) transporter
L083_RS24365	COG0577	efflux transmembrane transporter activity
L083_RS24370	COG0318	PFAM AMP-dependent synthetase and ligase
L083_RS24380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L083_RS24390	COG0515	serine threonine protein kinase
L083_RS24395	COG0631	protein serine/threonine phosphatase activity
L083_RS24415	COG0483	inositol monophosphate 1-phosphatase activity
L083_RS24425	COG4682	membrane
L083_RS24430	COG4581	dead DEAH box helicase
L083_RS24435	COG0546	phosphoglycolate phosphatase activity
L083_RS24460	COG1119	ATPase activity
L083_RS24465	COG0805	protein transport
L083_RS24470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L083_RS24480	COG2378	regulation of single-species biofilm formation
L083_RS24505	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
L083_RS24520	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
L083_RS24525	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
L083_RS24540	COG4122	O-methyltransferase activity
L083_RS24545	COG1222	aaa ATPase
L083_RS24550	COG1141	Ferredoxin
L083_RS24565	COG0517	IMP dehydrogenase activity
L083_RS24565	COG1994	Peptidase M50
L083_RS24600	COG1136	(ABC) transporter
L083_RS24605	COG0577	efflux transmembrane transporter activity
L083_RS24605	COG1136	(ABC) transporter
L083_RS24610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L083_RS24620	COG0667	Aldo Keto reductase
L083_RS24625	COG4941	Belongs to the sigma-70 factor family
L083_RS24630	COG3795	YCII-related domain
L083_RS24645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L083_RS24740	COG0215	cysteine-tRNA ligase activity
L083_RS24760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS24765	COG0667	Aldo Keto reductase
L083_RS24775	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS24775	COG0604	alcohol dehydrogenase
L083_RS24775	COG3321	synthase
L083_RS24800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L083_RS24810	COG0583	DNA-binding transcription factor activity
L083_RS24815	COG0542	response to heat
L083_RS24835	COG1674	ftsk spoiiie
L083_RS24885	COG0745	RESPONSE REGULATOR receiver
L083_RS24915	COG0653	protein targeting
L083_RS24920	COG1132	(ABC) transporter
L083_RS24935	COG0463	Glycosyl transferase, family 2
L083_RS24950	COG2201	protein-glutamate methylesterase activity
L083_RS24965	COG1191	sigma factor activity
L083_RS25060	COG1797	cobyrinic acid a,c-diamide synthase activity
L083_RS25070	COG1070	Carbohydrate kinase
L083_RS25075	COG1819	glycosyl
L083_RS25090	COG5001	Diguanylate cyclase
L083_RS25095	COG0708	Exodeoxyribonuclease III
L083_RS25135	COG1643	Atp-dependent helicase
L083_RS25140	COG0784	Response regulator, receiver
L083_RS25145	COG4251	negative regulation of phosphorylation
L083_RS25150	COG3951	Flagellar rod assembly protein muramidase FlgJ
L083_RS25150	COG1705	Flagellar rod assembly protein muramidase FlgJ
L083_RS25180	COG3467	pyridoxamine 5'-phosphate
L083_RS25210	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L083_RS25220	COG3629	intracellular signal transduction
L083_RS25220	COG3903	Transcriptional regulator
L083_RS25225	COG3591	Belongs to the peptidase S1B family
L083_RS25225	COG1864	DNA RNA non-specific endonuclease
L083_RS25230	COG2022	thiamine diphosphate biosynthetic process
L083_RS25280	COG2197	response regulator
L083_RS25285	COG2183	response to ionizing radiation
L083_RS25290	COG2409	Drug exporters of the RND superfamily
L083_RS25310	COG2197	response regulator
L083_RS25415	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L083_RS25450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L083_RS25460	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
L083_RS25470	COG0584	glycerophosphoryl diester phosphodiesterase
L083_RS25495	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L083_RS25505	COG1960	acyl-CoA dehydrogenase activity
L083_RS25520	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L083_RS25525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L083_RS25535	COG1414	Transcriptional regulator
L083_RS25540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L083_RS25595	COG3480	Lon protease (S16) C-terminal proteolytic domain
L083_RS25620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L083_RS25625	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L083_RS25640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L083_RS25650	COG0438	transferase activity, transferring glycosyl groups
L083_RS25680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L083_RS25695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L083_RS25705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L083_RS25715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L083_RS25750	COG4213	ABC transporter substrate-binding protein
L083_RS25755	COG1172	Belongs to the binding-protein-dependent transport system permease family
L083_RS25765	COG2409	Drug exporters of the RND superfamily
L083_RS25780	COG1132	(ABC) transporter
L083_RS25785	COG1252	NADH dehydrogenase
L083_RS25820	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L083_RS25825	COG0366	Alpha amylase catalytic
L083_RS25835	COG0277	FAD linked oxidase domain protein
L083_RS25850	COG0183	Belongs to the thiolase family
L083_RS25860	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L083_RS25870	COG0477	Major facilitator Superfamily
L083_RS25920	COG0789	Transcriptional regulator
L083_RS25950	COG0667	Aldo Keto reductase
L083_RS25975	COG0730	response to heat
L083_RS25995	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS26005	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L083_RS26035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_RS26055	COG0494	nUDIX hydrolase
L083_RS26060	COG5297	Belongs to the glycosyl hydrolase family 6
L083_RS26155	COG0531	amino acid
L083_RS26260	COG1960	acyl-CoA dehydrogenase activity
L083_RS26320	COG0028	Belongs to the TPP enzyme family
L083_RS26335	COG1573	uracil-dna glycosylase
L083_RS26365	COG1309	transcriptional regulator
L083_RS26380	COG0738	Major facilitator superfamily
L083_RS26410	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L083_RS26415	COG0477	Major facilitator Superfamily
L083_RS26430	COG1131	(ABC) transporter
L083_RS26455	COG3511	phospholipase C
L083_RS26485	COG0640	Transcriptional regulator
L083_RS26495	COG0247	lactate metabolic process
L083_RS26495	COG0277	FAD linked oxidase domain protein
L083_RS26500	COG1802	Transcriptional regulator
L083_RS26510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L083_RS26560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L083_RS26595	COG2814	Major facilitator Superfamily
L083_RS26600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L083_RS26610	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L083_RS26665	COG0778	Nitroreductase
L083_RS26690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L083_RS26710	COG0640	Transcriptional regulator
L083_RS26720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS26730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L083_RS26740	COG1940	carbohydrate kinase activity
L083_RS26780	COG0024	Methionine aminopeptidase
L083_RS26810	COG3629	intracellular signal transduction
L083_RS26810	COG3903	Transcriptional regulator
L083_RS26825	COG1595	DNA-templated transcription, initiation
L083_RS26845	COG1136	(ABC) transporter
L083_RS26905	COG2197	response regulator
L083_RS26905	COG3903	Transcriptional regulator
L083_RS26915	COG0473	3-isopropylmalate dehydrogenase activity
L083_RS26920	COG0436	Aminotransferase
L083_RS26925	COG0066	3-isopropylmalate dehydratase activity
L083_RS26930	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L083_RS26950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L083_RS26955	COG2192	nodulation
L083_RS26980	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L083_RS26985	COG4677	pectinesterase activity
L083_RS27005	COG0395	ABC-type sugar transport system, permease component
L083_RS27030	COG0395	ABC-type sugar transport system, permease component
L083_RS27035	COG1175	transmembrane transport
L083_RS27040	COG1653	transport
L083_RS27045	COG0657	acetylesterase activity
L083_RS27065	COG2755	lipolytic protein G-D-S-L family
L083_RS27075	COG0604	alcohol dehydrogenase
L083_RS27110	COG3507	Belongs to the glycosyl hydrolase 43 family
L083_RS27115	COG3693	PFAM glycoside hydrolase, family 10
L083_RS27140	COG0515	serine threonine protein kinase
L083_RS27140	COG2815	serine threonine protein kinase
L083_RS27150	COG3485	protocatechuate 3,4-dioxygenase
L083_RS27155	COG1454	alcohol dehydrogenase
L083_RS27165	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L083_RS27180	COG1510	regulation of RNA biosynthetic process
L083_RS27185	COG1131	(ABC) transporter
L083_RS27200	COG5297	Belongs to the glycosyl hydrolase family 6
L083_RS27235	COG1846	Transcriptional regulator
L083_RS27240	COG2409	Drug exporters of the RND superfamily
L083_RS27305	COG2274	protein secretion by the type I secretion system
L083_RS27310	COG2124	cytochrome p450
L083_RS27315	COG0017	Asparaginyl-tRNA synthetase
L083_RS27325	COG0442	prolyl-tRNA aminoacylation
L083_RS27335	COG1619	proteins homologs of microcin C7 resistance protein MccF
L083_RS27345	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L083_RS27355	COG3629	intracellular signal transduction
L083_RS27355	COG3903	Transcriptional regulator
L083_RS27370	COG1672	PFAM Archaeal ATPase
L083_RS27370	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L083_RS27375	COG4412	M6 family metalloprotease domain protein
L083_RS27375	COG1404	Belongs to the peptidase S8 family
L083_RS27380	COG3618	amidohydrolase
L083_RS27400	COG1129	ABC transporter
L083_RS27405	COG1172	Belongs to the binding-protein-dependent transport system permease family
L083_RS27410	COG4948	Mandelate Racemase Muconate Lactonizing
L083_RS27415	COG2186	Transcriptional regulator
L083_RS27420	COG2186	Transcriptional regulator
L083_RS27445	COG0395	ABC-type sugar transport system, permease component
L083_RS27450	COG1175	transmembrane transport
L083_RS27460	COG1063	alcohol dehydrogenase
L083_RS27465	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS27470	COG0800	Aldolase
L083_RS27505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L083_RS27530	COG2072	flavoprotein involved in K transport
L083_RS27540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L083_RS27545	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L083_RS27550	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L083_RS27575	COG0546	phosphoglycolate phosphatase activity
L083_RS27590	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
L083_RS27600	COG0604	alcohol dehydrogenase
L083_RS27600	COG3321	synthase
L083_RS27610	COG1960	acyl-CoA dehydrogenase activity
L083_RS27615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L083_RS27635	COG1063	alcohol dehydrogenase
L083_RS27650	COG0604	alcohol dehydrogenase
L083_RS27650	COG3321	synthase
L083_RS27665	COG4122	O-methyltransferase activity
L083_RS27680	COG2890	protein-(glutamine-N5) methyltransferase activity
L083_RS27685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS27690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_RS27710	COG0798	PFAM Bile acid sodium symporter
L083_RS27715	COG5002	protein histidine kinase activity
L083_RS27715	COG3850	Histidine kinase
L083_RS27735	COG0745	RESPONSE REGULATOR receiver
L083_RS27740	COG5002	protein histidine kinase activity
L083_RS27745	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
L083_RS27745	COG2755	lipolytic protein G-D-S-L family
L083_RS27875	COG1160	GTP binding
L083_RS27880	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L083_RS27885	COG1187	pseudouridine synthase activity
L083_RS27890	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L083_RS27970	COG4221	oxidoreductase activity
L083_RS27995	COG4221	oxidoreductase activity
L083_RS28000	COG0583	DNA-binding transcription factor activity
L083_RS28025	COG1752	Esterase of the alpha-beta hydrolase superfamily
L083_RS28045	COG1752	Esterase of the alpha-beta hydrolase superfamily
L083_RS28090	COG0494	nUDIX hydrolase
L083_RS28095	COG0504	CTP synthase activity
L083_RS28105	COG0297	glycogen (starch) synthase activity
L083_RS28135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L083_RS28155	COG0647	UMP catabolic process
L083_RS28185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L083_RS28190	COG2326	polyphosphate kinase activity
L083_RS28205	COG0563	adenylate kinase activity
L083_RS28250	COG2094	Belongs to the DNA glycosylase MPG family
L083_RS28275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_RS28290	COG1733	regulation of RNA biosynthetic process
L083_RS28315	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L083_RS28320	COG0406	alpha-ribazole phosphatase activity
L083_RS28335	COG1175	transmembrane transport
L083_RS28340	COG0395	ABC-type sugar transport system, permease component
L083_RS28350	COG0583	DNA-binding transcription factor activity
L083_RS28355	COG0730	response to heat
L083_RS28365	COG0165	Argininosuccinate lyase
L083_RS28370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L083_RS28375	COG0137	argininosuccinate synthase activity
L083_RS28385	COG1438	arginine binding
L083_RS28395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L083_RS28400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L083_RS28405	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L083_RS28410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L083_RS28430	COG0454	-acetyltransferase
L083_RS28430	COG0456	acetyltransferase
L083_RS28435	COG2949	membrane
L083_RS28470	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
L083_RS28480	COG2318	DinB family
L083_RS28500	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS28505	COG0072	phenylalanine-tRNA ligase activity
L083_RS28505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L083_RS28510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L083_RS28515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L083_RS28520	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L083_RS28525	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L083_RS28530	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L083_RS28540	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L083_RS28545	COG0140	phosphoribosyl-ATP diphosphatase activity
L083_RS28550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L083_RS28555	COG0765	amino acid transport
L083_RS28565	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L083_RS28570	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L083_RS28570	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L083_RS28585	COG0745	RESPONSE REGULATOR receiver
L083_RS28605	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L083_RS28610	COG0242	peptide deformylase activity
L083_RS28620	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L083_RS28635	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L083_RS28645	COG1758	RNA polymerase activity
L083_RS28650	COG0194	GDP metabolic process
L083_RS28655	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L083_RS28660	COG0284	orotidine-5'-phosphate decarboxylase activity
L083_RS28670	COG0167	dihydroorotate dehydrogenase activity
L083_RS28680	COG0505	Belongs to the CarA family
L083_RS28685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L083_RS28690	COG0540	Belongs to the ATCase OTCase family
L083_RS28695	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
L083_RS28705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L083_RS28710	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L083_RS28715	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L083_RS28720	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L083_RS28725	COG0542	response to heat
L083_RS28730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L083_RS28735	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L083_RS28750	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L083_RS28755	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L083_RS28760	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L083_RS28765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L083_RS28830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L083_RS28845	COG0477	Major facilitator Superfamily
L083_RS29000	COG0740	serine-type endopeptidase activity
L083_RS29170	COG1595	DNA-templated transcription, initiation
L083_RS29185	COG3964	amidohydrolase
L083_RS29190	COG0251	oxidation-reduction process
L083_RS29205	COG0831	urea catabolic process
L083_RS29210	COG0832	Belongs to the urease beta subunit family
L083_RS29215	COG0804	urea catabolic process
L083_RS29225	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
L083_RS29230	COG0829	nickel cation binding
L083_RS29245	COG0515	serine threonine protein kinase
L083_RS29250	COG0189	ligase activity
L083_RS29250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L083_RS29260	COG2814	Major facilitator Superfamily
L083_RS29280	COG0124	histidyl-tRNA synthetase
L083_RS29295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L083_RS29305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L083_RS29310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L083_RS29330	COG2255	four-way junction helicase activity
L083_RS29335	COG0632	four-way junction helicase activity
L083_RS29340	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L083_RS29350	COG0217	transcriptional regulatory protein
L083_RS29355	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
L083_RS29360	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
L083_RS29370	COG0438	transferase activity, transferring glycosyl groups
L083_RS29375	COG1560	Kdo2-lipid A biosynthetic process
L083_RS29395	COG1595	DNA-templated transcription, initiation
L083_RS29430	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L083_RS29440	COG0667	Aldo Keto reductase
L083_RS29450	COG1278	Cold shock
L083_RS29485	COG1472	Belongs to the glycosyl hydrolase 3 family
L083_RS29495	COG0514	ATP-dependent DNA helicase (RecQ)
L083_RS29520	COG2084	Dehydrogenase
L083_RS29530	COG3850	Histidine kinase
L083_RS29555	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS29615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L083_RS29665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L083_RS29685	COG2197	response regulator
L083_RS29705	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L083_RS29720	COG4266	Belongs to the allantoicase family
L083_RS29725	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L083_RS29735	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L083_RS29765	COG1643	Atp-dependent helicase
L083_RS29865	COG0840	transmembrane signaling receptor activity
L083_RS29870	COG2382	esterase
L083_RS29875	COG2226	methyltransferase
L083_RS29885	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L083_RS29925	COG0405	Gamma-glutamyltransferase
L083_RS29930	COG1132	(ABC) transporter
L083_RS29965	COG2936	dipeptidyl-peptidase activity
L083_RS29970	COG1082	Xylose isomerase domain protein TIM barrel
L083_RS29985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L083_RS29990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS29995	COG1216	Glycosyl transferase, family 2
L083_RS30000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS30025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS30040	COG1686	Belongs to the peptidase S11 family
L083_RS30055	COG1191	sigma factor activity
L083_RS30060	COG3973	AAA domain
L083_RS30065	COG1191	sigma factor activity
L083_RS30070	COG0513	Belongs to the DEAD box helicase family
L083_RS30100	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L083_RS30105	COG1609	Transcriptional regulator
L083_RS30120	COG0601	transmembrane transport
L083_RS30125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L083_RS30130	COG0444	Belongs to the ABC transporter superfamily
L083_RS30135	COG2723	6-phospho-beta-galactosidase activity
L083_RS30150	COG1940	carbohydrate kinase activity
L083_RS30165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_RS30175	COG3347	Dehydrogenase
L083_RS30175	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS30180	COG0657	acetylesterase activity
L083_RS30185	COG1595	DNA-templated transcription, initiation
L083_RS30195	COG0154	amidase activity
L083_RS30200	COG4733	cellulase activity
L083_RS30200	COG5297	Belongs to the glycosyl hydrolase family 6
L083_RS30235	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L083_RS30240	COG0187	DNA topoisomerase II activity
L083_RS30255	COG2197	response regulator
L083_RS30270	COG2205	protein histidine kinase activity
L083_RS30275	COG0745	RESPONSE REGULATOR receiver
L083_RS30320	COG0387	Pfam Sodium calcium exchanger
L083_RS30325	COG0435	Glutathione S-transferase
L083_RS30340	COG0714	Associated with various cellular activities
L083_RS30355	COG3552	Protein containing von Willebrand factor type A (VWA) domain
L083_RS30435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L083_RS30440	COG0543	2 iron, 2 sulfur cluster binding
L083_RS30440	COG0633	Ferredoxin
L083_RS30475	COG1794	racemase activity, acting on amino acids and derivatives
L083_RS30480	COG3191	aminopeptidase activity
L083_RS30485	COG4565	transcriptional regulatory protein
L083_RS30490	COG3290	protein histidine kinase activity
L083_RS30500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L083_RS30505	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L083_RS30520	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L083_RS30530	COG0515	serine threonine protein kinase
L083_RS30575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L083_RS30580	COG1136	(ABC) transporter
L083_RS30590	COG4181	ATPase activity
L083_RS30605	COG0598	Magnesium transport protein CorA
L083_RS30615	COG0300	oxidoreductase activity
L083_RS30620	COG1595	DNA-templated transcription, initiation
L083_RS30635	COG3119	arylsulfatase activity
L083_RS30640	COG1619	proteins homologs of microcin C7 resistance protein MccF
L083_RS30665	COG0246	Mannitol dehydrogenase
L083_RS30670	COG1904	glucuronate isomerase
L083_RS30685	COG0395	ABC-type sugar transport system, permease component
L083_RS30700	COG0673	inositol 2-dehydrogenase activity
L083_RS30710	COG1609	Transcriptional regulator
L083_RS30715	COG1606	tRNA processing
L083_RS30720	COG1691	(AIR) carboxylase
L083_RS30725	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
L083_RS30735	COG4585	Histidine kinase
L083_RS30825	COG0596	Alpha beta hydrolase
L083_RS30835	COG0671	phosphoesterase, PA-phosphatase related
L083_RS30845	COG1803	Methylglyoxal synthase
L083_RS30845	COG1597	lipid kinase activity
L083_RS30850	COG4762	Protein conserved in bacteria
L083_RS30890	COG0477	Major facilitator Superfamily
L083_RS30910	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L083_RS30925	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L083_RS30940	COG0746	molybdenum cofactor guanylyltransferase activity
L083_RS30955	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS30970	COG0800	Aldolase
L083_RS30995	COG0366	Alpha amylase catalytic
L083_RS31000	COG0438	transferase activity, transferring glycosyl groups
L083_RS31005	COG0438	transferase activity, transferring glycosyl groups
L083_RS31020	COG2226	methyltransferase
L083_RS31025	COG0673	inositol 2-dehydrogenase activity
L083_RS31030	COG0702	epimerase
L083_RS31050	COG3012	SEC-C Motif Domain Protein
L083_RS31055	COG0789	Transcriptional regulator
L083_RS31060	COG0840	transmembrane signaling receptor activity
L083_RS31065	COG1609	Transcriptional regulator
L083_RS31070	COG1653	transport
L083_RS31075	COG1175	transmembrane transport
L083_RS31085	COG0366	Alpha amylase catalytic
L083_RS31100	COG1595	DNA-templated transcription, initiation
L083_RS31115	COG0659	secondary active sulfate transmembrane transporter activity
L083_RS31120	COG2308	Evidence 4 Homologs of previously reported genes of
L083_RS31120	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L083_RS31125	COG0367	asparagine synthase
L083_RS31130	COG1506	peptidase
L083_RS31175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L083_RS31185	COG2814	Major facilitator Superfamily
L083_RS31215	COG0725	ABC transporter, periplasmic molybdate-binding protein
L083_RS31250	COG1136	(ABC) transporter
L083_RS31290	COG0500	methyltransferase
L083_RS31325	COG1215	transferase activity, transferring glycosyl groups
L083_RS31360	COG1131	(ABC) transporter
L083_RS31375	COG0328	RNA-DNA hybrid ribonuclease activity
L083_RS31415	COG0010	Belongs to the arginase family
L083_RS31425	COG4585	Histidine kinase
L083_RS31430	COG2197	response regulator
L083_RS31435	COG3537	Alpha-1,2-mannosidase
L083_RS31440	COG3467	pyridoxamine 5'-phosphate
L083_RS31460	COG1653	transport
L083_RS31465	COG1175	transmembrane transport
L083_RS31470	COG0395	ABC-type sugar transport system, permease component
L083_RS31475	COG1609	Transcriptional regulator
L083_RS31495	COG3537	Alpha-1,2-mannosidase
L083_RS31545	COG0702	epimerase
L083_RS31605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L083_RS31670	COG0823	Involved in the tonB-independent uptake of proteins
L083_RS31675	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L083_RS31685	COG1477	protein flavinylation
L083_RS31710	COG2226	methyltransferase
L083_RS31735	COG0640	Transcriptional regulator
L083_RS31750	COG1472	Belongs to the glycosyl hydrolase 3 family
L083_RS31780	COG2409	Drug exporters of the RND superfamily
L083_RS31800	COG5001	Diguanylate cyclase
L083_RS31820	COG2197	response regulator
L083_RS31855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L083_RS31860	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS31865	COG2197	response regulator
L083_RS31885	COG0395	ABC-type sugar transport system, permease component
L083_RS31890	COG1175	transmembrane transport
L083_RS31900	COG4821	SIS domain
L083_RS31905	COG1737	Transcriptional regulator
L083_RS31930	COG1063	alcohol dehydrogenase
L083_RS31935	COG1473	amidohydrolase
L083_RS31940	COG2197	response regulator
L083_RS31945	COG0318	PFAM AMP-dependent synthetase and ligase
L083_RS31970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L083_RS31975	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L083_RS31980	COG2080	2 iron, 2 sulfur cluster binding
L083_RS32005	COG2188	Transcriptional regulator
L083_RS32010	COG1984	allophanate hydrolase subunit 2
L083_RS32015	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
L083_RS32020	COG4336	lyase activity
L083_RS32025	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
L083_RS32030	COG1914	H( )-stimulated, divalent metal cation uptake system
L083_RS32035	COG2264	protein methyltransferase activity
L083_RS32110	COG0419	ATPase involved in DNA repair
L083_RS32115	COG0420	3'-5' exonuclease activity
L083_RS32150	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
L083_RS32155	COG1253	flavin adenine dinucleotide binding
L083_RS32200	COG0232	Belongs to the dGTPase family. Type 2 subfamily
L083_RS32225	COG1309	transcriptional regulator
L083_RS32230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L083_RS32250	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS32255	COG1793	dna ligase
L083_RS32265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L083_RS32285	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L083_RS32295	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L083_RS32300	COG3253	May function as heme-dependent peroxidase
L083_RS32305	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS32325	COG0655	NAD(P)H dehydrogenase (quinone) activity
L083_RS32340	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
L083_RS32350	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L083_RS32370	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
L083_RS32375	COG0183	Belongs to the thiolase family
L083_RS32380	COG1250	3-hydroxyacyl-CoA dehydrogenase
L083_RS32380	COG1024	Enoyl-CoA hydratase
L083_RS32395	COG2205	protein histidine kinase activity
L083_RS32400	COG0745	RESPONSE REGULATOR receiver
L083_RS32420	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L083_RS32425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L083_RS32430	COG0531	amino acid
L083_RS32435	COG0569	domain protein
L083_RS32460	COG0756	dUTP diphosphatase activity
L083_RS32485	COG0483	inositol monophosphate 1-phosphatase activity
L083_RS32510	COG2860	membrane
L083_RS32520	COG2313	pseudouridylate synthase activity
L083_RS32565	COG1490	D-aminoacyl-tRNA deacylase activity
L083_RS32590	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L083_RS32595	COG0123	including yeast histone deacetylase and acetoin utilization protein
L083_RS32635	COG0738	Major facilitator superfamily
L083_RS32645	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L083_RS32650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L083_RS32655	COG1388	LysM domain
L083_RS32660	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L083_RS32680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L083_RS32690	COG0584	glycerophosphoryl diester phosphodiesterase
L083_RS32695	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L083_RS32700	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L083_RS32705	COG1196	nuclear chromosome segregation
L083_RS32715	COG0640	Transcriptional regulator
L083_RS32725	COG1733	regulation of RNA biosynthetic process
L083_RS32730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L083_RS32740	COG1126	abc transporter atp-binding protein
L083_RS32745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L083_RS32750	COG0765	amino acid transport
L083_RS32755	COG0765	amino acid transport
L083_RS32760	COG1418	mRNA catabolic process
L083_RS32775	COG2137	regulation of response to DNA damage stimulus
L083_RS32780	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L083_RS32790	COG1573	uracil-dna glycosylase
L083_RS32810	COG4326	sporulation control protein
L083_RS32815	COG1253	flavin adenine dinucleotide binding
L083_RS32825	COG2815	serine threonine protein kinase
L083_RS32825	COG0515	serine threonine protein kinase
L083_RS32840	COG1201	RNA secondary structure unwinding
L083_RS32860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L083_RS32870	COG1842	Phage shock protein A
L083_RS32875	COG1396	sequence-specific DNA binding
L083_RS32880	COG1546	Belongs to the CinA family
L083_RS32880	COG1058	Belongs to the CinA family
L083_RS32890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L083_RS32895	COG1674	ftsk spoiiie
L083_RS32915	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L083_RS32920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L083_RS32930	COG3214	Protein conserved in bacteria
L083_RS32940	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L083_RS32950	COG0612	Peptidase, M16
L083_RS32955	COG1185	polyribonucleotide nucleotidyltransferase activity
L083_RS32960	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L083_RS32975	COG0745	RESPONSE REGULATOR receiver
L083_RS32980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L083_RS32995	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L083_RS33010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L083_RS33020	COG0195	Participates in both transcription termination and antitermination
L083_RS33025	COG0779	Required for maturation of 30S ribosomal subunits
L083_RS33065	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L083_RS33070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L083_RS33080	COG1012	belongs to the aldehyde dehydrogenase family
L083_RS33115	COG4152	abc transporter atp-binding protein
L083_RS33120	COG1668	transmembrane transport
L083_RS33125	COG1309	transcriptional regulator
L083_RS33130	COG1511	domain protein
L083_RS33135	COG1121	(ABC) transporter
L083_RS33160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L083_RS33190	COG2146	nitrite reductase [NAD(P)H] activity
L083_RS33190	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L083_RS33205	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L083_RS33215	COG0233	cytoplasmic translational termination
L083_RS33220	COG0528	UMP kinase activity
L083_RS33225	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L083_RS33230	COG0052	Belongs to the universal ribosomal protein uS2 family
L083_RS33240	COG0792	nuclease activity
L083_RS33280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L083_RS33295	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L083_RS33305	COG0681	Belongs to the peptidase S26 family
L083_RS33310	COG0681	Belongs to the peptidase S26 family
L083_RS33315	COG0335	large ribosomal subunit rRNA binding
L083_RS33320	COG0336	Belongs to the RNA methyltransferase TrmD family
L083_RS33325	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L083_RS33330	COG1837	Belongs to the UPF0109 family
L083_RS33335	COG0228	four-way junction DNA binding
L083_RS33375	COG0438	transferase activity, transferring glycosyl groups
L083_RS33385	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
L083_RS33385	COG2755	lipolytic protein G-D-S-L family
L083_RS33400	COG0463	Glycosyl transferase, family 2
L083_RS33405	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
L083_RS33445	COG2318	DinB family
L083_RS33475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L083_RS33485	COG0571	ribonuclease III activity
L083_RS33490	COG0416	fatty acid biosynthetic process
L083_RS33495	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L083_RS33510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L083_RS33515	COG0742	ribosomal rna small subunit methyltransferase
L083_RS33550	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L083_RS33585	COG1131	(ABC) transporter
L083_RS33590	COG2188	Transcriptional regulator
L083_RS33600	COG0626	cystathionine gamma-synthase activity
L083_RS33605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L083_RS33615	COG1920	GTP binding
L083_RS33625	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L083_RS33630	COG0406	alpha-ribazole phosphatase activity
L083_RS33630	COG0494	nUDIX hydrolase
L083_RS33640	COG0776	regulation of translation
L083_RS33645	COG0066	3-isopropylmalate dehydratase activity
L083_RS33690	COG1476	TRANSCRIPTIONal
L083_RS33700	COG1131	(ABC) transporter
L083_RS33710	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
L083_RS33715	COG2205	protein histidine kinase activity
L083_RS33720	COG0745	RESPONSE REGULATOR receiver
L083_RS33725	COG0612	Peptidase, M16
L083_RS33740	COG0583	DNA-binding transcription factor activity
L083_RS33755	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L083_RS33765	COG1864	DNA RNA non-specific endonuclease
L083_RS33765	COG3591	Belongs to the peptidase S1B family
L083_RS33770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L083_RS33775	COG0473	3-isopropylmalate dehydrogenase activity
L083_RS33785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L083_RS33795	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L083_RS33800	COG0440	acetolactate synthase activity
L083_RS33810	COG3300	MHYT domain
L083_RS33810	COG5001	Diguanylate cyclase
L083_RS33815	COG0129	dihydroxy-acid dehydratase activity
L083_RS33825	COG0784	Response regulator, receiver
L083_RS33830	COG4251	negative regulation of phosphorylation
L083_RS33840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L083_RS33850	COG3833	ABC-type maltose transport systems, permease component
L083_RS33855	COG1175	transmembrane transport
L083_RS33865	COG1609	Transcriptional regulator
L083_RS33905	COG2133	pyrroloquinoline quinone binding
L083_RS33915	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L083_RS33920	COG0154	amidase activity
L083_RS33925	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L083_RS33935	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L083_RS33950	COG0482	sulfurtransferase activity
L083_RS33960	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L083_RS33970	COG2149	membrane
L083_RS33990	COG0443	Heat shock 70 kDa protein
L083_RS34015	COG0840	transmembrane signaling receptor activity
L083_RS34025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L083_RS34030	COG1119	ATPase activity
L083_RS34040	COG1472	Belongs to the glycosyl hydrolase 3 family
L083_RS34070	COG2902	Dehydrogenase
L083_RS34080	COG0010	Belongs to the arginase family
L083_RS34090	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L083_RS34090	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L083_RS34105	COG1703	isobutyryl-CoA mutase activity
L083_RS34110	COG0183	Belongs to the thiolase family
L083_RS34115	COG0346	lactoylglutathione lyase activity
L083_RS34165	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
L083_RS34180	COG1674	ftsk spoiiie
L083_RS34190	COG1250	3-hydroxyacyl-CoA dehydrogenase
L083_RS34225	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L083_RS34235	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L083_RS34240	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L083_RS34245	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L083_RS34250	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L083_RS34255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L083_RS34260	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L083_RS34265	COG0356	it plays a direct role in the translocation of protons across the membrane
L083_RS34275	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L083_RS34280	COG0702	epimerase
L083_RS34285	COG0009	L-threonylcarbamoyladenylate synthase
L083_RS34290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L083_RS34300	COG2890	protein-(glutamine-N5) methyltransferase activity
L083_RS34320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L083_RS34325	COG0254	rRNA binding
L083_RS34350	COG0083	homoserine kinase activity
L083_RS34360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L083_RS34375	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L083_RS34380	COG0460	homoserine dehydrogenase
L083_RS34385	COG0019	diaminopimelate decarboxylase activity
L083_RS34390	COG0018	arginyl-trna synthetase
L083_RS34415	COG1120	ATPase activity
L083_RS34420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L083_RS34425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L083_RS34430	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
L083_RS34455	COG2986	histidine ammonia-lyase
L083_RS34475	COG0475	glutathione-regulated potassium exporter activity
L083_RS34480	COG0745	RESPONSE REGULATOR receiver
L083_RS34515	COG4977	sequence-specific DNA binding
L083_RS34540	COG1309	transcriptional regulator
L083_RS34550	COG1742	UPF0060 membrane protein
L083_RS34600	COG1595	DNA-templated transcription, initiation
L083_RS34605	COG0673	inositol 2-dehydrogenase activity
L083_RS34630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L083_RS34635	COG2814	Major facilitator Superfamily
L083_RS34655	COG2226	methyltransferase
L083_RS34675	COG0318	PFAM AMP-dependent synthetase and ligase
L083_RS34680	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L083_RS34690	COG2197	response regulator
L083_RS34695	COG3629	intracellular signal transduction
L083_RS34710	COG0477	Major facilitator Superfamily
L083_RS34720	COG0754	glutathionylspermidine amidase activity
L083_RS34735	COG0366	Alpha amylase catalytic
L083_RS34755	COG0586	Pfam SNARE associated Golgi protein
L083_RS34760	COG3469	chitinase activity
L083_RS34775	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L083_RS34780	COG0446	pyridine nucleotide-disulphide oxidoreductase
L083_RS34790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L083_RS34810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L083_RS34815	COG1834	amidinotransferase
L083_RS34825	COG0740	serine-type endopeptidase activity
L083_RS34845	COG3842	ATPase activity
L083_RS34855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L083_RS34860	COG2205	protein histidine kinase activity
L083_RS34865	COG0745	RESPONSE REGULATOR receiver
L083_RS34880	COG1131	(ABC) transporter
L083_RS34890	COG0567	Dehydrogenase, E1 component
L083_RS34890	COG0508	dehydrogenase complex catalyzes the overall conversion of
L083_RS34905	COG4221	oxidoreductase activity
L083_RS34910	COG0280	phosphate acetyltransferase
L083_RS34910	COG0857	belongs to the CobB CobQ family
L083_RS34915	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L083_RS34930	COG1064	alcohol dehydrogenase
L083_RS34955	COG2172	sigma factor antagonist activity
L083_RS34960	COG2188	Transcriptional regulator
L083_RS34970	COG1597	lipid kinase activity
L083_RS34985	COG0175	sulfate reduction
L083_RS35015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L083_RS35025	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
L083_RS35035	COG1595	DNA-templated transcription, initiation
L083_RS35050	COG2135	peptidase activity
L083_RS35055	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L083_RS35060	COG1162	GTPase activity
L083_RS35065	COG0483	inositol monophosphate 1-phosphatase activity
L083_RS35085	COG2197	response regulator
L083_RS35150	COG1357	PFAM Pentapeptide repeats (8 copies)
L083_RS35185	COG1615	UPF0182 protein
L083_RS35190	COG3480	Lon protease (S16) C-terminal proteolytic domain
L083_RS35215	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L083_RS35245	COG2816	NAD+ diphosphatase activity
L083_RS35260	COG1959	2 iron, 2 sulfur cluster binding
L083_RS35270	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L083_RS35290	COG1278	Cold shock
L083_RS35310	COG1609	Transcriptional regulator
L083_RS35315	COG2171	N-acyltransferase activity
L083_RS35325	COG1611	Belongs to the LOG family
L083_RS35330	COG1611	Belongs to the LOG family
L083_RS35355	COG0789	Transcriptional regulator
L083_RS35370	COG2226	methyltransferase
L083_RS35380	COG2199	diguanylate cyclase activity
L083_RS35380	COG2200	EAL domain
L083_RS35380	COG3287	FIST C domain
L083_RS35465	COG1215	transferase activity, transferring glycosyl groups
L083_RS35495	COG0463	Glycosyl transferase, family 2
L083_RS35500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L083_RS35535	COG0297	glycogen (starch) synthase activity
L083_RS35545	COG0297	glycogen (starch) synthase activity
L083_RS35585	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L083_RS35625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_RS35650	COG0656	L-ascorbic acid biosynthetic process
L083_RS35680	COG1404	Belongs to the peptidase S8 family
L083_RS35705	COG0456	acetyltransferase
L083_RS35725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L083_RS35745	COG3706	GGDEF domain
L083_RS35750	COG0312	modulator of DNA gyrase
L083_RS35770	COG1053	succinate dehydrogenase
L083_RS35850	COG1960	acyl-CoA dehydrogenase activity
L083_RS35860	COG0039	L-malate dehydrogenase activity
L083_RS35865	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
L083_RS35870	COG0121	glutamine amidotransferase
L083_RS35875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L083_RS35900	COG1960	acyl-CoA dehydrogenase activity
L083_RS35905	COG0318	PFAM AMP-dependent synthetase and ligase
L083_RS35950	COG0431	NADPH-dependent FMN reductase
L083_RS36065	COG0012	GTP binding
L083_RS36080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L083_RS36090	COG0525	valine-tRNA ligase activity
L083_RS36130	COG1722	exodeoxyribonuclease VII activity
L083_RS36135	COG1570	exodeoxyribonuclease VII activity
L083_RS36150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L083_RS36160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_RS36190	COG1322	Protein conserved in bacteria
L083_RS36195	COG0705	Rhomboid family
L083_RS36210	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L083_RS36215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L083_RS36215	COG0561	phosphatase activity
L083_RS36225	COG0644	oxidoreductase
L083_RS36235	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
L083_RS36270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L083_RS36280	COG0424	maF-like protein
L083_RS36330	COG4770	biotin carboxylase activity
L083_RS36370	COG1473	amidohydrolase
L083_RS36370	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L083_RS36375	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L083_RS36375	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L083_RS36380	COG0515	serine threonine protein kinase
L083_RS36385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L083_RS36400	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L083_RS36405	COG1051	belongs to the nudix hydrolase family
L083_RS36410	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L083_RS36415	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
L083_RS36420	COG1012	belongs to the aldehyde dehydrogenase family
L083_RS36425	COG1012	belongs to the aldehyde dehydrogenase family
L083_RS36460	COG2018	Roadblock/LC7 domain
L083_RS36470	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L083_RS36495	COG1079	Belongs to the binding-protein-dependent transport system permease family
L083_RS36500	COG4603	Belongs to the binding-protein-dependent transport system permease family
L083_RS36505	COG3845	ABC transporter
L083_RS36510	COG1744	ABC transporter substrate-binding protein PnrA-like
L083_RS36525	COG1309	transcriptional regulator
L083_RS36545	COG0180	Tryptophanyl-tRNA synthetase
L083_RS36550	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L083_RS36555	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
L083_RS36575	COG1218	3'(2'),5'-bisphosphate nucleotidase
L083_RS36580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L083_RS36585	COG0193	aminoacyl-tRNA hydrolase activity
L083_RS36600	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L083_RS36640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L083_RS36655	COG1309	transcriptional regulator
L083_RS36670	COG0488	(ABC) transporter
L083_RS36675	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
L083_RS36685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L083_RS36695	COG0084	hydrolase, TatD family'
L083_RS36720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L083_RS36760	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L083_RS36795	COG0303	'Molybdopterin
L083_RS36800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L083_RS36855	COG3415	Transposase
L083_RS36855	COG2801	Transposase and inactivated derivatives
L083_RS36860	COG2095	MarC family integral membrane protein
L083_RS36865	COG0613	PHP domain protein
L083_RS36885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L083_RS36895	COG1832	CoA-binding protein
L083_RS36905	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS36935	COG0384	phenazine biosynthesis protein PhzF
L083_RS36940	COG2239	Acts as a magnesium transporter
L083_RS36955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L083_RS36960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L083_RS36970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L083_RS36980	COG1024	Enoyl-CoA hydratase
L083_RS36995	COG0519	Catalyzes the synthesis of GMP from XMP
L083_RS37010	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L083_RS37015	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L083_RS37015	COG0674	pyruvate-flavodoxin oxidoreductase activity
L083_RS37020	COG1013	pyruvate-flavodoxin oxidoreductase activity
L083_RS37025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L083_RS37070	COG0113	porphobilinogen synthase activity
L083_RS37075	COG1648	precorrin-2 dehydrogenase activity
L083_RS37075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L083_RS37080	COG0181	hydroxymethylbilane synthase activity
L083_RS37085	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
L083_RS37090	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
L083_RS37105	COG0318	PFAM AMP-dependent synthetase and ligase
L083_RS37110	COG1595	DNA-templated transcription, initiation
L083_RS37135	COG0506	proline dehydrogenase activity
L083_RS37145	COG1082	Xylose isomerase domain protein TIM barrel
L083_RS37170	COG0588	phosphoglycerate mutase activity
L083_RS37180	COG0835	chemotaxis
L083_RS37200	COG0438	transferase activity, transferring glycosyl groups
L083_RS37235	COG2205	protein histidine kinase activity
L083_RS37255	COG1196	nuclear chromosome segregation
L083_RS37255	COG0739	heme binding
L083_RS37255	COG0741	lytic transglycosylase activity
L083_RS37260	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
L083_RS37265	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
L083_RS37275	COG1256	bacterial-type flagellum assembly
L083_RS37275	COG4786	Flagellar basal body rod
L083_RS37285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L083_RS37295	COG1516	flagellar protein fliS
L083_RS37305	COG1815	bacterial-type flagellum-dependent cell motility
L083_RS37315	COG1677	Flagellar hook-basal body complex protein FliE
L083_RS37320	COG1766	The M ring may be actively involved in energy transduction
L083_RS37325	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L083_RS37335	COG1157	protein secretion by the type III secretion system
L083_RS37345	COG0483	inositol monophosphate 1-phosphatase activity
L083_RS37350	COG0583	DNA-binding transcription factor activity
L083_RS37360	COG0741	lytic transglycosylase activity
L083_RS37360	COG0739	heme binding
L083_RS37360	COG1196	nuclear chromosome segregation
L083_RS37370	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
L083_RS37385	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L083_RS37400	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L083_RS37405	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L083_RS37405	COG1776	CheC inhibitor of MCP methylation
L083_RS37415	COG1338	Plays a role in the flagellum-specific transport system
L083_RS37425	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L083_RS37430	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L083_RS37455	COG0745	RESPONSE REGULATOR receiver
L083_RS37465	COG0745	RESPONSE REGULATOR receiver
L083_RS37475	COG2201	protein-glutamate methylesterase activity
L083_RS37485	COG0835	chemotaxis
L083_RS37490	COG0784	Response regulator, receiver
L083_RS37490	COG0643	Histidine kinase
L083_RS37490	COG2198	Histidine kinase
L083_RS37495	COG0745	RESPONSE REGULATOR receiver
L083_RS37500	COG2198	Histidine kinase
L083_RS37500	COG0784	Response regulator, receiver
L083_RS37500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L083_RS37500	COG2205	protein histidine kinase activity
L083_RS37510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L083_RS37565	COG3246	L-lysine catabolic process to acetate
L083_RS37575	COG0735	belongs to the Fur family
L083_RS37580	COG4044	May play a role in the intracellular transport of hydrophobic ligands
L083_RS37615	COG0745	RESPONSE REGULATOR receiver
L083_RS37620	COG0456	acetyltransferase
L083_RS37625	COG3483	tryptophan 2,3-dioxygenase activity
L083_RS37630	COG1522	sequence-specific DNA binding
L083_RS37635	COG2814	Major facilitator Superfamily
L083_RS37655	COG0581	inorganic phosphate transmembrane transporter activity
L083_RS37660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L083_RS37670	COG0673	inositol 2-dehydrogenase activity
L083_RS37685	COG0306	phosphate transporter
L083_RS37725	COG2339	peptidase activity
L083_RS37760	COG0459	protein refolding
L083_RS37765	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L083_RS37770	COG0456	acetyltransferase
L083_RS37785	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L083_RS37790	COG1131	(ABC) transporter
L083_RS37805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L083_RS37815	COG1131	(ABC) transporter
L083_RS37825	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
L083_RS37840	COG1349	DNA-binding transcription factor activity
L083_RS37845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L083_RS37855	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L083_RS37885	COG0114	fumarate hydratase activity
L083_RS37895	COG0215	cysteine-tRNA ligase activity
L083_RS37900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L083_RS37905	COG0443	Heat shock 70 kDa protein
L083_RS37910	COG3842	ATPase activity
L083_RS37920	COG2226	methyltransferase
L083_RS37940	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L083_RS37940	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L083_RS37955	COG3185	4-Hydroxyphenylpyruvate dioxygenase
L083_RS37970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L083_RS38020	COG1940	carbohydrate kinase activity
L083_RS38020	COG1846	Transcriptional regulator
L083_RS38030	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L083_RS38035	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L083_RS38060	COG1960	acyl-CoA dehydrogenase activity
L083_RS38065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L083_RS38080	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L083_RS38085	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
L083_RS38095	COG1194	a g-specific adenine glycosylase
L083_RS38120	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
L083_RS38130	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
L083_RS38140	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
L083_RS38145	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
L083_RS38160	COG0649	NAD binding
L083_RS38175	COG1174	glycine betaine transport
L083_RS38180	COG1174	glycine betaine transport
L083_RS38185	COG0517	IMP dehydrogenase activity
L083_RS38185	COG1125	glycine betaine transport
L083_RS38215	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L083_RS38220	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L083_RS38250	COG0739	heme binding
L083_RS38265	COG1674	ftsk spoiiie
L083_RS38280	COG0302	gtp cyclohydrolase
L083_RS38285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L083_RS38290	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L083_RS38295	COG0037	tRNA processing
L083_RS38305	COG2027	D-alanyl-D-alanine carboxypeptidase
L083_RS38310	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L083_RS38320	COG1674	ftsk spoiiie
L083_RS38340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L083_RS38345	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L083_RS38350	COG2843	Capsule synthesis protein
L083_RS38360	COG0825	malonyl-CoA metabolic process
L083_RS38400	COG0003	Pfam Anion-transporting ATPase
L083_RS38415	COG1610	YqeY-like protein
L083_RS38440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L083_RS38485	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L083_RS38490	COG1324	tolerance protein
L083_RS38495	COG0789	Transcriptional regulator
L083_RS38515	COG4608	Belongs to the ABC transporter superfamily
L083_RS38535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L083_RS38540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L083_RS38545	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L083_RS38570	COG1309	transcriptional regulator
L083_RS38590	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L083_RS38605	COG0590	tRNA wobble adenosine to inosine editing
L083_RS38610	COG0813	purine-nucleoside phosphorylase activity
L083_RS38680	COG2318	DinB family
L083_RS38685	COG0287	Prephenate dehydrogenase
L083_RS38720	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L083_RS38720	COG1796	DNA polymerase
L083_RS38740	COG0642	Histidine kinase
L083_RS38745	COG2018	Roadblock/LC7 domain
L083_RS38765	COG2255	four-way junction helicase activity
L083_RS38785	COG1215	transferase activity, transferring glycosyl groups
L083_RS38790	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L083_RS38840	COG3706	GGDEF domain
L083_RS38890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L083_RS38910	COG0745	RESPONSE REGULATOR receiver
L083_RS38915	COG2205	protein histidine kinase activity
L083_RS38980	COG2197	response regulator
L083_RS38985	COG4585	Histidine kinase
L083_RS39000	COG0745	RESPONSE REGULATOR receiver
L083_RS39005	COG5002	protein histidine kinase activity
L083_RS39015	COG1136	(ABC) transporter
L083_RS39020	COG0577	efflux transmembrane transporter activity
L083_RS39020	COG1136	(ABC) transporter
L083_RS39035	COG0640	Transcriptional regulator
L083_RS39040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L083_RS39085	COG4585	Histidine kinase
L083_RS39090	COG2197	response regulator
L083_RS39105	COG4221	oxidoreductase activity
L083_RS39110	COG0702	epimerase
L083_RS39120	COG2207	Transcriptional regulator
L083_RS39155	COG0242	peptide deformylase activity
L083_RS39175	COG1881	PFAM PEBP family protein
L083_RS39180	COG5002	protein histidine kinase activity
L083_RS39190	COG3103	Sh3 type 3 domain protein
L083_RS39190	COG0791	NLP P60 protein
L083_RS39190	COG1388	LysM domain
L083_RS39195	COG0321	lipoyl(octanoyl) transferase activity
L083_RS39215	COG0604	alcohol dehydrogenase
L083_RS39215	COG1028	Short-chain dehydrogenase reductase Sdr
L083_RS39215	COG3321	synthase
L083_RS39220	COG3469	chitinase activity
L083_RS39240	COG0371	Dehydrogenase
L083_RS39255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L083_RS39260	COG0598	Magnesium transport protein CorA
L083_RS39275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L083_RS39290	COG0183	Belongs to the thiolase family
L083_RS39300	COG3958	Transketolase
L083_RS39305	COG3959	Transketolase, thiamine diphosphate binding domain
L083_RS39310	COG0789	Transcriptional regulator
L083_RS39325	COG0438	transferase activity, transferring glycosyl groups
L083_RS39330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L083_RS39335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L083_RS39340	COG3275	phosphorelay sensor kinase activity
L083_RS39355	COG2205	protein histidine kinase activity
L083_RS39365	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L083_RS39385	COG0180	Tryptophanyl-tRNA synthetase
L083_RS39400	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L083_RS39405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L083_RS39410	COG1316	TRANSCRIPTIONal
L083_RS39415	COG1316	TRANSCRIPTIONal
L083_RS39430	COG5002	protein histidine kinase activity
L083_RS39470	COG0789	Transcriptional regulator
L083_RS39475	COG1064	alcohol dehydrogenase
L083_RS39490	COG1764	response to oxidative stress
L083_RS39500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L083_RS39505	COG0561	phosphatase activity
L083_RS39510	COG0561	phosphatase activity
L083_RS39520	COG1834	amidinotransferase
L083_RS39525	COG1522	sequence-specific DNA binding
L083_RS39550	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L083_RS39555	COG3540	Alkaline phosphatase
L083_RS39575	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L083_RS39585	COG1408	metallophosphoesterase
L083_RS39595	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L083_RS39630	COG0521	Mo-molybdopterin cofactor biosynthetic process
L083_RS39630	COG0315	cyclic pyranopterin monophosphate synthase activity
L083_RS39635	COG0315	cyclic pyranopterin monophosphate synthase activity
L083_RS39640	COG5001	Diguanylate cyclase
L083_RS39640	COG3300	MHYT domain
L083_RS39690	COG0305	Participates in initiation and elongation during chromosome replication
L083_RS39705	COG0359	binds to the 23S rRNA
L083_RS39710	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L083_RS39720	COG0360	Binds together with S18 to 16S ribosomal RNA
L083_RS39745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L083_RS39770	COG0617	tRNA 3'-terminal CCA addition
L083_RS39785	COG2815	serine threonine protein kinase
L083_RS39785	COG0515	serine threonine protein kinase
L083_RS39790	COG1595	DNA-templated transcription, initiation
L083_RS39800	COG0492	ferredoxin-NADP+ reductase activity
L083_RS39805	COG3118	belongs to the thioredoxin family
L083_RS39810	COG3409	Peptidoglycan-binding domain 1 protein
L083_RS39810	COG0860	N-Acetylmuramoyl-L-alanine amidase
L083_RS39820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L083_RS39825	COG1181	Belongs to the D-alanine--D-alanine ligase family
L083_RS39840	COG1192	Involved in chromosome partitioning
L083_RS39845	COG0357	Ribosomal RNA small subunit methyltransferase G
L083_RS39855	COG0706	membrane insertase activity
L083_RS39860	COG0594	ribonuclease P activity
L083_RS39865	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L083_RS39900	COG4974	Belongs to the 'phage' integrase family
L083_RS39980	COG4585	Histidine kinase
L083_RS39985	COG5001	Diguanylate cyclase
L083_RS40125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L083_RS40150	COG0840	transmembrane signaling receptor activity
L083_RS40255	COG1309	transcriptional regulator
L083_RS40270	COG2205	protein histidine kinase activity
L083_RS40285	COG2197	response regulator
L083_RS40310	COG1674	ftsk spoiiie
L083_RS40345	COG0515	serine threonine protein kinase
L083_RS40350	COG0515	serine threonine protein kinase
L083_RS40360	COG0438	transferase activity, transferring glycosyl groups
L083_RS40380	COG2197	response regulator
L083_RS40390	COG0671	phosphoesterase, PA-phosphatase related
L083_RS40440	COG5001	Diguanylate cyclase
L083_RS40440	COG3300	MHYT domain
L083_RS40485	COG5001	Diguanylate cyclase
L083_RS40490	COG3629	intracellular signal transduction
L083_RS40490	COG3903	Transcriptional regulator
L083_RS40500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_RS40520	COG5479	isomerase activity
L083_RS40520	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
L083_RS40530	COG3629	intracellular signal transduction
L083_RS40530	COG3903	Transcriptional regulator
L083_RS40535	COG3584	3D domain protein
L083_RS40535	COG3583	domain protein
L083_RS40565	COG0640	Transcriptional regulator
L083_RS40595	COG2197	response regulator
L083_RS40740	COG5001	Diguanylate cyclase
L083_RS40760	COG4124	Belongs to the glycosyl hydrolase 26 family
L083_RS40760	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
L083_RS40800	COG0443	Heat shock 70 kDa protein
L083_RS40850	COG0515	serine threonine protein kinase
L083_RS40870	COG1250	3-hydroxyacyl-CoA dehydrogenase
L083_RS40870	COG1024	Enoyl-CoA hydratase
L083_RS40905	COG2124	cytochrome p450
L083_RS41045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L083_RS41075	COG0784	Response regulator, receiver
L083_RS41075	COG2205	protein histidine kinase activity
L083_RS41075	COG5002	protein histidine kinase activity
L083_RS41095	COG2815	serine threonine protein kinase
L083_RS41095	COG0515	serine threonine protein kinase
L083_RS41145	COG0438	transferase activity, transferring glycosyl groups
L083_RS41175	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L083_RS41265	COG2188	Transcriptional regulator