locus-tag	class	description
EP757_RS00005	COG0601	transmembrane transport
EP757_RS00020	COG3250	beta-galactosidase activity
EP757_RS00030	COG3507	Belongs to the glycosyl hydrolase 43 family
EP757_RS00045	COG3250	beta-galactosidase activity
EP757_RS00055	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS00075	COG0657	acetylesterase activity
EP757_RS00085	COG2197	response regulator
EP757_RS00090	COG4585	Histidine kinase
EP757_RS00105	COG1073	alpha beta
EP757_RS00125	COG0583	DNA-binding transcription factor activity
EP757_RS00130	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS00140	COG1733	regulation of RNA biosynthetic process
EP757_RS00175	COG1160	GTP binding
EP757_RS00195	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EP757_RS00260	COG0789	Transcriptional regulator
EP757_RS00285	COG2267	carboxylic ester hydrolase activity
EP757_RS00320	COG1733	regulation of RNA biosynthetic process
EP757_RS00340	COG0183	Belongs to the thiolase family
EP757_RS00345	COG1024	Enoyl-CoA hydratase
EP757_RS00345	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP757_RS00360	COG1132	(ABC) transporter
EP757_RS00365	COG0318	PFAM AMP-dependent synthetase and ligase
EP757_RS00370	COG5001	Diguanylate cyclase
EP757_RS00370	COG3300	MHYT domain
EP757_RS00390	COG2814	Major facilitator Superfamily
EP757_RS00395	COG0583	DNA-binding transcription factor activity
EP757_RS00410	COG1187	pseudouridine synthase activity
EP757_RS00415	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EP757_RS00420	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EP757_RS00485	COG0504	CTP synthase activity
EP757_RS00525	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EP757_RS00560	COG0647	UMP catabolic process
EP757_RS00590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EP757_RS00595	COG2326	polyphosphate kinase activity
EP757_RS00605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EP757_RS00610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EP757_RS00615	COG1063	alcohol dehydrogenase
EP757_RS00640	COG1349	DNA-binding transcription factor activity
EP757_RS00690	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EP757_RS00695	COG2094	Belongs to the DNA glycosylase MPG family
EP757_RS00700	COG3973	AAA domain
EP757_RS00710	COG1177	transmembrane transport
EP757_RS00715	COG1176	ABC-type spermidine putrescine transport system, permease component I
EP757_RS00720	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EP757_RS00725	COG3842	ATPase activity
EP757_RS00750	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EP757_RS00755	COG0406	alpha-ribazole phosphatase activity
EP757_RS00770	COG0730	response to heat
EP757_RS00790	COG1079	Belongs to the binding-protein-dependent transport system permease family
EP757_RS00795	COG4603	Belongs to the binding-protein-dependent transport system permease family
EP757_RS00800	COG3845	ABC transporter
EP757_RS00805	COG1744	ABC transporter substrate-binding protein PnrA-like
EP757_RS00810	COG1802	Transcriptional regulator
EP757_RS00825	COG3833	ABC-type maltose transport systems, permease component
EP757_RS00855	COG0165	Argininosuccinate lyase
EP757_RS00860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EP757_RS00865	COG0137	argininosuccinate synthase activity
EP757_RS00880	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EP757_RS00885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EP757_RS00890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EP757_RS00895	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EP757_RS00900	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EP757_RS00920	COG1733	regulation of RNA biosynthetic process
EP757_RS00925	COG1472	Belongs to the glycosyl hydrolase 3 family
EP757_RS00930	COG3572	ergothioneine biosynthetic process
EP757_RS00935	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EP757_RS00940	COG0121	glutamine amidotransferase
EP757_RS00945	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
EP757_RS00965	COG3552	Protein containing von Willebrand factor type A (VWA) domain
EP757_RS00970	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EP757_RS00975	COG0714	Associated with various cellular activities
EP757_RS00980	COG3831	ATPase activity
EP757_RS01015	COG0072	phenylalanine-tRNA ligase activity
EP757_RS01015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP757_RS01020	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EP757_RS01025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EP757_RS01030	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EP757_RS01035	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EP757_RS01040	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EP757_RS01050	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EP757_RS01055	COG0140	phosphoribosyl-ATP diphosphatase activity
EP757_RS01065	COG0765	amino acid transport
EP757_RS01075	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EP757_RS01080	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EP757_RS01080	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EP757_RS01105	COG0745	RESPONSE REGULATOR receiver
EP757_RS01125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EP757_RS01130	COG0242	peptide deformylase activity
EP757_RS01145	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EP757_RS01155	COG1758	RNA polymerase activity
EP757_RS01160	COG0194	GDP metabolic process
EP757_RS01170	COG0284	orotidine-5'-phosphate decarboxylase activity
EP757_RS01175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EP757_RS01180	COG0167	dihydroorotate dehydrogenase activity
EP757_RS01190	COG0505	Belongs to the CarA family
EP757_RS01195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EP757_RS01200	COG0540	Belongs to the ATCase OTCase family
EP757_RS01205	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EP757_RS01220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EP757_RS01225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EP757_RS01230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EP757_RS01235	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EP757_RS01245	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EP757_RS01250	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EP757_RS01255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EP757_RS01265	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EP757_RS01270	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EP757_RS01275	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EP757_RS01330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EP757_RS01355	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
EP757_RS01365	COG0395	ABC-type sugar transport system, permease component
EP757_RS01385	COG3964	amidohydrolase
EP757_RS01390	COG0251	oxidation-reduction process
EP757_RS01395	COG0515	serine threonine protein kinase
EP757_RS01400	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EP757_RS01400	COG2755	lipolytic protein G-D-S-L family
EP757_RS01405	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EP757_RS01405	COG2124	cytochrome p450
EP757_RS01415	COG0831	urea catabolic process
EP757_RS01420	COG0832	Belongs to the urease beta subunit family
EP757_RS01435	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EP757_RS01440	COG0829	nickel cation binding
EP757_RS01465	COG0515	serine threonine protein kinase
EP757_RS01470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EP757_RS01470	COG0189	ligase activity
EP757_RS01495	COG0124	histidyl-tRNA synthetase
EP757_RS01515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EP757_RS01520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EP757_RS01525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EP757_RS01535	COG1862	Preprotein translocase
EP757_RS01540	COG2255	four-way junction helicase activity
EP757_RS01545	COG0632	four-way junction helicase activity
EP757_RS01550	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EP757_RS01560	COG0217	transcriptional regulatory protein
EP757_RS01565	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EP757_RS01570	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EP757_RS01580	COG0438	transferase activity, transferring glycosyl groups
EP757_RS01585	COG1560	Kdo2-lipid A biosynthetic process
EP757_RS01620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EP757_RS01635	COG2205	protein histidine kinase activity
EP757_RS01645	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EP757_RS01655	COG0667	Aldo Keto reductase
EP757_RS01665	COG1278	Cold shock
EP757_RS01705	COG1472	Belongs to the glycosyl hydrolase 3 family
EP757_RS01710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS01715	COG0514	ATP-dependent DNA helicase (RecQ)
EP757_RS01725	COG1609	Transcriptional regulator
EP757_RS01730	COG0683	leucine binding
EP757_RS01740	COG1079	Belongs to the binding-protein-dependent transport system permease family
EP757_RS01750	COG0410	ABC transporter
EP757_RS01765	COG4106	trans-aconitate 2-methyltransferase activity
EP757_RS01770	COG1672	PFAM Archaeal ATPase
EP757_RS01770	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EP757_RS01775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP757_RS01810	COG2197	response regulator
EP757_RS01815	COG4585	Histidine kinase
EP757_RS01830	COG0438	transferase activity, transferring glycosyl groups
EP757_RS01890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP757_RS01915	COG0542	response to heat
EP757_RS01945	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EP757_RS01955	COG4266	Belongs to the allantoicase family
EP757_RS01960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EP757_RS01985	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EP757_RS02010	COG1643	Atp-dependent helicase
EP757_RS02015	COG5001	Diguanylate cyclase
EP757_RS02015	COG3300	MHYT domain
EP757_RS02035	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EP757_RS02100	COG5002	protein histidine kinase activity
EP757_RS02105	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EP757_RS02125	COG0405	Gamma-glutamyltransferase
EP757_RS02150	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP757_RS02155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP757_RS02170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS02210	COG1686	Belongs to the peptidase S11 family
EP757_RS02220	COG1191	sigma factor activity
EP757_RS02225	COG3973	AAA domain
EP757_RS02235	COG1191	sigma factor activity
EP757_RS02240	COG0513	Belongs to the DEAD box helicase family
EP757_RS02270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EP757_RS02275	COG1609	Transcriptional regulator
EP757_RS02280	COG4166	transmembrane transport
EP757_RS02290	COG0601	transmembrane transport
EP757_RS02295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EP757_RS02300	COG0444	Belongs to the ABC transporter superfamily
EP757_RS02325	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EP757_RS02330	COG0187	DNA topoisomerase II activity
EP757_RS02355	COG2205	protein histidine kinase activity
EP757_RS02360	COG0745	RESPONSE REGULATOR receiver
EP757_RS02365	COG0435	Glutathione S-transferase
EP757_RS02385	COG0714	Associated with various cellular activities
EP757_RS02395	COG3552	Protein containing von Willebrand factor type A (VWA) domain
EP757_RS02400	COG2226	methyltransferase
EP757_RS02415	COG1404	Belongs to the peptidase S8 family
EP757_RS02450	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EP757_RS02485	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EP757_RS02490	COG1017	nitric oxide dioxygenase activity
EP757_RS02490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EP757_RS02510	COG0395	ABC-type sugar transport system, permease component
EP757_RS02535	COG2755	lipolytic protein G-D-S-L family
EP757_RS02545	COG0515	serine threonine protein kinase
EP757_RS02555	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EP757_RS02560	COG1136	(ABC) transporter
EP757_RS02565	COG1136	(ABC) transporter
EP757_RS02580	COG0598	Magnesium transport protein CorA
EP757_RS02585	COG3201	nicotinamide mononucleotide transporter
EP757_RS02610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EP757_RS02615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS02620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS02625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS02660	COG3328	transposase activity
EP757_RS02665	COG0366	Alpha amylase catalytic
EP757_RS02665	COG1874	Beta-galactosidase
EP757_RS02670	COG2319	Wd-40 repeat
EP757_RS02680	COG3629	intracellular signal transduction
EP757_RS02690	COG0596	Alpha beta hydrolase
EP757_RS02765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS02840	COG2197	response regulator
EP757_RS02845	COG4585	Histidine kinase
EP757_RS02900	COG1063	alcohol dehydrogenase
EP757_RS02915	COG2318	DinB family
EP757_RS02925	COG0671	phosphoesterase, PA-phosphatase related
EP757_RS02935	COG1597	lipid kinase activity
EP757_RS02935	COG1803	Methylglyoxal synthase
EP757_RS02970	COG0745	RESPONSE REGULATOR receiver
EP757_RS02990	COG2197	response regulator
EP757_RS02995	COG3850	Histidine kinase
EP757_RS03035	COG1335	isochorismatase
EP757_RS03060	COG0800	Aldolase
EP757_RS03105	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
EP757_RS03110	COG0366	Alpha amylase catalytic
EP757_RS03115	COG0438	transferase activity, transferring glycosyl groups
EP757_RS03120	COG0438	transferase activity, transferring glycosyl groups
EP757_RS03135	COG2226	methyltransferase
EP757_RS03140	COG0673	inositol 2-dehydrogenase activity
EP757_RS03155	COG3483	tryptophan 2,3-dioxygenase activity
EP757_RS03160	COG3012	SEC-C Motif Domain Protein
EP757_RS03165	COG0840	transmembrane signaling receptor activity
EP757_RS03170	COG4941	Belongs to the sigma-70 factor family
EP757_RS03185	COG1653	transport
EP757_RS03190	COG1175	transmembrane transport
EP757_RS03195	COG0395	ABC-type sugar transport system, permease component
EP757_RS03200	COG0366	Alpha amylase catalytic
EP757_RS03210	COG0659	secondary active sulfate transmembrane transporter activity
EP757_RS03215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EP757_RS03220	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EP757_RS03220	COG2308	Evidence 4 Homologs of previously reported genes of
EP757_RS03225	COG0367	asparagine synthase
EP757_RS03230	COG1506	peptidase
EP757_RS03230	COG0823	Involved in the tonB-independent uptake of proteins
EP757_RS03230	COG4946	Tricorn protease homolog
EP757_RS03260	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EP757_RS03295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EP757_RS03330	COG2197	response regulator
EP757_RS03355	COG1131	(ABC) transporter
EP757_RS03360	COG0328	RNA-DNA hybrid ribonuclease activity
EP757_RS03405	COG5001	Diguanylate cyclase
EP757_RS03410	COG2197	response regulator
EP757_RS03415	COG4585	Histidine kinase
EP757_RS03430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EP757_RS03450	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EP757_RS03530	COG2807	transmembrane transport
EP757_RS03550	COG0058	SHG alpha-glucan phosphorylase activity
EP757_RS03570	COG0142	geranyltranstransferase activity
EP757_RS03575	COG1960	acyl-CoA dehydrogenase activity
EP757_RS03590	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EP757_RS03590	COG1082	Xylose isomerase domain protein TIM barrel
EP757_RS03595	COG1309	transcriptional regulator
EP757_RS03600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EP757_RS03610	COG2304	oxidoreductase activity
EP757_RS03625	COG0714	Associated with various cellular activities
EP757_RS03630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP757_RS03640	COG3693	PFAM glycoside hydrolase, family 10
EP757_RS03650	COG0714	Associated with various cellular activities
EP757_RS03655	COG3552	Protein containing von Willebrand factor type A (VWA) domain
EP757_RS03670	COG2409	Drug exporters of the RND superfamily
EP757_RS03755	COG1309	transcriptional regulator
EP757_RS03760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP757_RS03765	COG3328	transposase activity
EP757_RS03815	COG0633	Ferredoxin
EP757_RS03815	COG0543	2 iron, 2 sulfur cluster binding
EP757_RS03870	COG3328	transposase activity
EP757_RS03890	COG3486	L-lysine 6-monooxygenase (NADPH) activity
EP757_RS03910	COG0395	ABC-type sugar transport system, permease component
EP757_RS03915	COG1175	transmembrane transport
EP757_RS03940	COG1960	acyl-CoA dehydrogenase activity
EP757_RS03945	COG5001	Diguanylate cyclase
EP757_RS03965	COG2197	response regulator
EP757_RS03980	COG0028	Belongs to the TPP enzyme family
EP757_RS04015	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EP757_RS04085	COG0419	ATPase involved in DNA repair
EP757_RS04090	COG0420	3'-5' exonuclease activity
EP757_RS04100	COG1595	DNA-templated transcription, initiation
EP757_RS04125	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EP757_RS04130	COG0156	8-amino-7-oxononanoate synthase activity
EP757_RS04135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EP757_RS04155	COG2264	protein methyltransferase activity
EP757_RS04195	COG4978	Transcriptional regulator
EP757_RS04195	COG0789	Transcriptional regulator
EP757_RS04200	COG1793	dna ligase
EP757_RS04210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP757_RS04220	COG3285	dna ligase
EP757_RS04220	COG1793	dna ligase
EP757_RS04235	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EP757_RS04245	COG0463	Glycosyl transferase, family 2
EP757_RS04255	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EP757_RS04260	COG0655	NAD(P)H dehydrogenase (quinone) activity
EP757_RS04265	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EP757_RS04275	COG3253	May function as heme-dependent peroxidase
EP757_RS04280	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EP757_RS04285	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EP757_RS04295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP757_RS04300	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EP757_RS04310	COG0183	Belongs to the thiolase family
EP757_RS04315	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP757_RS04315	COG1024	Enoyl-CoA hydratase
EP757_RS04325	COG2205	protein histidine kinase activity
EP757_RS04330	COG0745	RESPONSE REGULATOR receiver
EP757_RS04350	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EP757_RS04355	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EP757_RS04360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EP757_RS04365	COG0531	amino acid
EP757_RS04370	COG0569	domain protein
EP757_RS04395	COG0756	dUTP diphosphatase activity
EP757_RS04440	COG2860	membrane
EP757_RS04450	COG2313	pseudouridylate synthase activity
EP757_RS04455	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EP757_RS04455	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EP757_RS04485	COG0745	RESPONSE REGULATOR receiver
EP757_RS04495	COG0643	Histidine kinase
EP757_RS04495	COG2198	Histidine kinase
EP757_RS04495	COG0784	Response regulator, receiver
EP757_RS04495	COG0643	Histidine kinase
EP757_RS04495	COG0784	Response regulator, receiver
EP757_RS04495	COG2198	Histidine kinase
EP757_RS04505	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EP757_RS04515	COG2201	protein-glutamate methylesterase activity
EP757_RS04520	COG0835	chemotaxis
EP757_RS04525	COG3290	protein histidine kinase activity
EP757_RS04525	COG0840	transmembrane signaling receptor activity
EP757_RS04535	COG1490	D-aminoacyl-tRNA deacylase activity
EP757_RS04580	COG0123	including yeast histone deacetylase and acetoin utilization protein
EP757_RS04585	COG0439	Biotin carboxylase
EP757_RS04595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EP757_RS04600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EP757_RS04605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EP757_RS04615	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EP757_RS04625	COG0584	glycerophosphoryl diester phosphodiesterase
EP757_RS04630	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EP757_RS04635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EP757_RS04640	COG1196	nuclear chromosome segregation
EP757_RS04645	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EP757_RS04655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EP757_RS04665	COG1126	abc transporter atp-binding protein
EP757_RS04670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP757_RS04675	COG0765	amino acid transport
EP757_RS04680	COG0765	amino acid transport
EP757_RS04685	COG1418	mRNA catabolic process
EP757_RS04690	COG2137	regulation of response to DNA damage stimulus
EP757_RS04700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EP757_RS04710	COG1573	uracil-dna glycosylase
EP757_RS04730	COG0515	serine threonine protein kinase
EP757_RS04730	COG2815	serine threonine protein kinase
EP757_RS04735	COG1201	RNA secondary structure unwinding
EP757_RS04755	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EP757_RS04765	COG1842	Phage shock protein A
EP757_RS04770	COG1396	sequence-specific DNA binding
EP757_RS04775	COG1546	Belongs to the CinA family
EP757_RS04775	COG1058	Belongs to the CinA family
EP757_RS04785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EP757_RS04805	COG1674	ftsk spoiiie
EP757_RS04820	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EP757_RS04825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EP757_RS04860	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EP757_RS04870	COG0612	Peptidase, M16
EP757_RS04875	COG1185	polyribonucleotide nucleotidyltransferase activity
EP757_RS04880	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EP757_RS04890	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EP757_RS04900	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EP757_RS04905	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EP757_RS04920	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EP757_RS04935	COG0779	Required for maturation of 30S ribosomal subunits
EP757_RS04975	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EP757_RS04980	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EP757_RS04990	COG1012	belongs to the aldehyde dehydrogenase family
EP757_RS05010	COG4585	Histidine kinase
EP757_RS05015	COG2197	response regulator
EP757_RS05020	COG4152	abc transporter atp-binding protein
EP757_RS05025	COG1668	transmembrane transport
EP757_RS05030	COG1309	transcriptional regulator
EP757_RS05035	COG1511	domain protein
EP757_RS05040	COG1132	(ABC) transporter
EP757_RS05055	COG0456	acetyltransferase
EP757_RS05065	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EP757_RS05070	COG0750	zinc metalloprotease
EP757_RS05090	COG2146	nitrite reductase [NAD(P)H] activity
EP757_RS05090	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EP757_RS05105	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EP757_RS05110	COG0575	Belongs to the CDS family
EP757_RS05115	COG0233	cytoplasmic translational termination
EP757_RS05120	COG0528	UMP kinase activity
EP757_RS05125	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EP757_RS05130	COG0052	Belongs to the universal ribosomal protein uS2 family
EP757_RS05135	COG0792	nuclease activity
EP757_RS05160	COG4974	Belongs to the 'phage' integrase family
EP757_RS05165	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EP757_RS05180	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EP757_RS05190	COG0681	Belongs to the peptidase S26 family
EP757_RS05195	COG0681	Belongs to the peptidase S26 family
EP757_RS05200	COG0335	large ribosomal subunit rRNA binding
EP757_RS05205	COG0336	Belongs to the RNA methyltransferase TrmD family
EP757_RS05210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EP757_RS05215	COG1837	Belongs to the UPF0109 family
EP757_RS05220	COG0228	four-way junction DNA binding
EP757_RS05230	COG0442	prolyl-tRNA aminoacylation
EP757_RS05235	COG1595	DNA-templated transcription, initiation
EP757_RS05270	COG0438	transferase activity, transferring glycosyl groups
EP757_RS05280	COG1216	Glycosyl transferase, family 2
EP757_RS05300	COG0463	Glycosyl transferase, family 2
EP757_RS05310	COG2755	lipolytic protein G-D-S-L family
EP757_RS05310	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EP757_RS05320	COG1216	Glycosyl transferase, family 2
EP757_RS05320	COG1442	glycosyl transferase family 8
EP757_RS05325	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EP757_RS05395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EP757_RS05405	COG0571	ribonuclease III activity
EP757_RS05410	COG0416	fatty acid biosynthetic process
EP757_RS05415	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EP757_RS05430	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EP757_RS05435	COG0742	ribosomal rna small subunit methyltransferase
EP757_RS05465	COG1461	Dihydroxyacetone kinase
EP757_RS05470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EP757_RS05505	COG1181	Belongs to the D-alanine--D-alanine ligase family
EP757_RS05520	COG0626	cystathionine gamma-synthase activity
EP757_RS05525	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EP757_RS05535	COG1920	GTP binding
EP757_RS05545	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EP757_RS05560	COG0776	regulation of translation
EP757_RS05565	COG0066	3-isopropylmalate dehydratase activity
EP757_RS05590	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EP757_RS05610	COG0702	epimerase
EP757_RS05620	COG1476	TRANSCRIPTIONal
EP757_RS05630	COG1131	(ABC) transporter
EP757_RS05640	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EP757_RS05660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EP757_RS05665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EP757_RS05675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EP757_RS05680	COG0473	3-isopropylmalate dehydrogenase activity
EP757_RS05695	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EP757_RS05700	COG0440	acetolactate synthase activity
EP757_RS05710	COG4251	negative regulation of phosphorylation
EP757_RS05710	COG5001	Diguanylate cyclase
EP757_RS05710	COG3706	GGDEF domain
EP757_RS05710	COG2203	Gaf domain
EP757_RS05715	COG0129	dihydroxy-acid dehydratase activity
EP757_RS05730	COG1175	transmembrane transport
EP757_RS05740	COG1609	Transcriptional regulator
EP757_RS05765	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EP757_RS05770	COG0154	amidase activity
EP757_RS05775	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EP757_RS05785	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EP757_RS05795	COG0482	sulfurtransferase activity
EP757_RS05805	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EP757_RS05810	COG2086	electron transfer activity
EP757_RS05815	COG2149	membrane
EP757_RS05850	COG0840	transmembrane signaling receptor activity
EP757_RS05855	COG0840	transmembrane signaling receptor activity
EP757_RS05860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP757_RS05865	COG1119	ATPase activity
EP757_RS05870	COG1940	carbohydrate kinase activity
EP757_RS05890	COG2902	Dehydrogenase
EP757_RS05895	COG0768	penicillin binding
EP757_RS05900	COG0010	Belongs to the arginase family
EP757_RS05905	COG3118	belongs to the thioredoxin family
EP757_RS05910	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EP757_RS05910	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EP757_RS05925	COG1703	isobutyryl-CoA mutase activity
EP757_RS05930	COG0183	Belongs to the thiolase family
EP757_RS05935	COG0346	lactoylglutathione lyase activity
EP757_RS05985	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
EP757_RS06000	COG1674	ftsk spoiiie
EP757_RS06010	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP757_RS06040	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EP757_RS06050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EP757_RS06055	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EP757_RS06060	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EP757_RS06065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EP757_RS06070	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EP757_RS06075	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EP757_RS06080	COG0356	it plays a direct role in the translocation of protons across the membrane
EP757_RS06095	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EP757_RS06100	COG0702	epimerase
EP757_RS06105	COG0009	L-threonylcarbamoyladenylate synthase
EP757_RS06110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EP757_RS06120	COG2890	protein-(glutamine-N5) methyltransferase activity
EP757_RS06135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EP757_RS06140	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EP757_RS06145	COG0254	rRNA binding
EP757_RS06165	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EP757_RS06175	COG0083	homoserine kinase activity
EP757_RS06185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP757_RS06195	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EP757_RS06200	COG0460	homoserine dehydrogenase
EP757_RS06210	COG0018	arginyl-trna synthetase
EP757_RS06230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EP757_RS06240	COG3469	chitinase activity
EP757_RS06275	COG0477	Major facilitator Superfamily
EP757_RS06315	COG0754	glutathionylspermidine amidase activity
EP757_RS06350	COG0586	Pfam SNARE associated Golgi protein
EP757_RS06355	COG3469	chitinase activity
EP757_RS06370	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EP757_RS06385	COG0740	serine-type endopeptidase activity
EP757_RS06395	COG1834	amidinotransferase
EP757_RS06400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EP757_RS06430	COG3118	belongs to the thioredoxin family
EP757_RS06445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP757_RS06450	COG2205	protein histidine kinase activity
EP757_RS06455	COG0745	RESPONSE REGULATOR receiver
EP757_RS06475	COG0567	Dehydrogenase, E1 component
EP757_RS06475	COG0508	dehydrogenase complex catalyzes the overall conversion of
EP757_RS06480	COG0857	belongs to the CobB CobQ family
EP757_RS06480	COG0280	phosphate acetyltransferase
EP757_RS06485	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EP757_RS06490	COG1064	alcohol dehydrogenase
EP757_RS06510	COG2172	sigma factor antagonist activity
EP757_RS06515	COG2188	Transcriptional regulator
EP757_RS06525	COG1597	lipid kinase activity
EP757_RS06540	COG0175	sulfate reduction
EP757_RS06545	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EP757_RS06555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EP757_RS06565	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EP757_RS06575	COG1595	DNA-templated transcription, initiation
EP757_RS06590	COG2135	peptidase activity
EP757_RS06595	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EP757_RS06600	COG1162	GTPase activity
EP757_RS06605	COG0483	inositol monophosphate 1-phosphatase activity
EP757_RS06675	COG1357	PFAM Pentapeptide repeats (8 copies)
EP757_RS06690	COG1615	UPF0182 protein
EP757_RS06695	COG3480	Lon protease (S16) C-terminal proteolytic domain
EP757_RS06720	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EP757_RS06750	COG2816	NAD+ diphosphatase activity
EP757_RS06765	COG1959	2 iron, 2 sulfur cluster binding
EP757_RS06775	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EP757_RS06795	COG1278	Cold shock
EP757_RS06805	COG0210	DNA helicase
EP757_RS06810	COG1074	ATP-dependent DNA helicase activity
EP757_RS06820	COG1611	Belongs to the LOG family
EP757_RS06825	COG1611	Belongs to the LOG family
EP757_RS06835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EP757_RS06840	COG2171	N-acyltransferase activity
EP757_RS06860	COG2226	methyltransferase
EP757_RS06905	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EP757_RS06910	COG1506	peptidase
EP757_RS06910	COG0823	Involved in the tonB-independent uptake of proteins
EP757_RS06915	COG0312	modulator of DNA gyrase
EP757_RS06930	COG1053	succinate dehydrogenase
EP757_RS06985	COG1960	acyl-CoA dehydrogenase activity
EP757_RS07000	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EP757_RS07015	COG0318	PFAM AMP-dependent synthetase and ligase
EP757_RS07080	COG0012	GTP binding
EP757_RS07090	COG2169	Transcriptional regulator
EP757_RS07090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EP757_RS07095	COG0525	valine-tRNA ligase activity
EP757_RS07110	COG1322	Protein conserved in bacteria
EP757_RS07115	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EP757_RS07130	COG1570	exodeoxyribonuclease VII activity
EP757_RS07135	COG1722	exodeoxyribonuclease VII activity
EP757_RS07150	COG0705	Rhomboid family
EP757_RS07165	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EP757_RS07170	COG0561	phosphatase activity
EP757_RS07170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP757_RS07175	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EP757_RS07185	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
EP757_RS07220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EP757_RS07255	COG0424	maF-like protein
EP757_RS07260	COG4770	biotin carboxylase activity
EP757_RS07305	COG1473	amidohydrolase
EP757_RS07305	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EP757_RS07310	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EP757_RS07310	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EP757_RS07315	COG0515	serine threonine protein kinase
EP757_RS07315	COG2815	serine threonine protein kinase
EP757_RS07320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EP757_RS07330	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EP757_RS07335	COG1051	belongs to the nudix hydrolase family
EP757_RS07340	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EP757_RS07350	COG1012	belongs to the aldehyde dehydrogenase family
EP757_RS07355	COG1012	belongs to the aldehyde dehydrogenase family
EP757_RS07385	COG2018	Roadblock/LC7 domain
EP757_RS07395	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EP757_RS07420	COG1079	Belongs to the binding-protein-dependent transport system permease family
EP757_RS07425	COG4603	Belongs to the binding-protein-dependent transport system permease family
EP757_RS07430	COG3845	ABC transporter
EP757_RS07435	COG1744	ABC transporter substrate-binding protein PnrA-like
EP757_RS07460	COG0180	Tryptophanyl-tRNA synthetase
EP757_RS07465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EP757_RS07470	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EP757_RS07475	COG2856	Zn peptidase
EP757_RS07505	COG1218	3'(2'),5'-bisphosphate nucleotidase
EP757_RS07515	COG0193	aminoacyl-tRNA hydrolase activity
EP757_RS07530	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EP757_RS07550	COG0488	(ABC) transporter
EP757_RS07555	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EP757_RS07565	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EP757_RS07570	COG0084	hydrolase, TatD family'
EP757_RS07595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP757_RS07695	COG0303	'Molybdopterin
EP757_RS07700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EP757_RS07755	COG2095	MarC family integral membrane protein
EP757_RS07760	COG0613	PHP domain protein
EP757_RS07780	COG3118	belongs to the thioredoxin family
EP757_RS07790	COG1832	CoA-binding protein
EP757_RS07795	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS07815	COG0546	phosphoglycolate phosphatase activity
EP757_RS07830	COG0384	phenazine biosynthesis protein PhzF
EP757_RS07835	COG2239	Acts as a magnesium transporter
EP757_RS07850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EP757_RS07855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP757_RS07865	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EP757_RS07880	COG1024	Enoyl-CoA hydratase
EP757_RS07890	COG0519	Catalyzes the synthesis of GMP from XMP
EP757_RS07905	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EP757_RS07910	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EP757_RS07910	COG0674	pyruvate-flavodoxin oxidoreductase activity
EP757_RS07915	COG1013	pyruvate-flavodoxin oxidoreductase activity
EP757_RS07930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EP757_RS07960	COG0113	porphobilinogen synthase activity
EP757_RS07965	COG1587	Uroporphyrinogen-III synthase
EP757_RS07965	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EP757_RS07970	COG0181	hydroxymethylbilane synthase activity
EP757_RS07975	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EP757_RS07980	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EP757_RS07995	COG0318	PFAM AMP-dependent synthetase and ligase
EP757_RS08000	COG1595	DNA-templated transcription, initiation
EP757_RS08030	COG0506	proline dehydrogenase activity
EP757_RS08040	COG1082	Xylose isomerase domain protein TIM barrel
EP757_RS08065	COG0588	phosphoglycerate mutase activity
EP757_RS08080	COG0438	transferase activity, transferring glycosyl groups
EP757_RS08095	COG0745	RESPONSE REGULATOR receiver
EP757_RS08110	COG5002	protein histidine kinase activity
EP757_RS08125	COG0739	heme binding
EP757_RS08130	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EP757_RS08135	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
EP757_RS08145	COG1256	bacterial-type flagellum assembly
EP757_RS08145	COG4786	Flagellar basal body rod
EP757_RS08165	COG1516	flagellar protein fliS
EP757_RS08175	COG1815	bacterial-type flagellum-dependent cell motility
EP757_RS08185	COG1677	Flagellar hook-basal body complex protein FliE
EP757_RS08190	COG1766	The M ring may be actively involved in energy transduction
EP757_RS08195	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EP757_RS08215	COG1196	nuclear chromosome segregation
EP757_RS08215	COG0739	heme binding
EP757_RS08215	COG0741	lytic transglycosylase activity
EP757_RS08235	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EP757_RS08250	COG1338	Plays a role in the flagellum-specific transport system
EP757_RS08260	COG1776	CheC inhibitor of MCP methylation
EP757_RS08260	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EP757_RS08290	COG1749	Flagellar hook protein flgE
EP757_RS08295	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EP757_RS08305	COG0745	RESPONSE REGULATOR receiver
EP757_RS08315	COG0745	RESPONSE REGULATOR receiver
EP757_RS08320	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EP757_RS08325	COG2201	protein-glutamate methylesterase activity
EP757_RS08340	COG2198	Histidine kinase
EP757_RS08340	COG0784	Response regulator, receiver
EP757_RS08340	COG0643	Histidine kinase
EP757_RS08345	COG0745	RESPONSE REGULATOR receiver
EP757_RS08350	COG2340	Cysteine-rich secretory protein family
EP757_RS08355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EP757_RS08410	COG3246	L-lysine catabolic process to acetate
EP757_RS08420	COG0735	belongs to the Fur family
EP757_RS08430	COG4044	May play a role in the intracellular transport of hydrophobic ligands
EP757_RS08445	COG1051	belongs to the nudix hydrolase family
EP757_RS08455	COG3557	Belongs to the UPF0374 family
EP757_RS08460	COG1595	DNA-templated transcription, initiation
EP757_RS08475	COG0306	phosphate transporter
EP757_RS08480	COG0673	inositol 2-dehydrogenase activity
EP757_RS08490	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EP757_RS08505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EP757_RS08510	COG0456	acetyltransferase
EP757_RS08515	COG0745	RESPONSE REGULATOR receiver
EP757_RS08555	COG4129	membrane
EP757_RS08580	COG0459	protein refolding
EP757_RS08595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EP757_RS08615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EP757_RS08630	COG1131	(ABC) transporter
EP757_RS08635	COG1349	DNA-binding transcription factor activity
EP757_RS08640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EP757_RS08695	COG3842	ATPase activity
EP757_RS08710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EP757_RS08715	COG0215	cysteine-tRNA ligase activity
EP757_RS08720	COG1404	Belongs to the peptidase S8 family
EP757_RS08725	COG0114	fumarate hydratase activity
EP757_RS08730	COG3903	Transcriptional regulator
EP757_RS08730	COG3629	intracellular signal transduction
EP757_RS08740	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EP757_RS08740	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EP757_RS08760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP757_RS08795	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EP757_RS08800	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EP757_RS08825	COG1960	acyl-CoA dehydrogenase activity
EP757_RS08830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EP757_RS08845	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EP757_RS08850	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EP757_RS08865	COG0242	peptide deformylase activity
EP757_RS08870	COG3830	Belongs to the UPF0237 family
EP757_RS08895	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EP757_RS08900	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EP757_RS08910	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EP757_RS08920	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EP757_RS08925	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EP757_RS08940	COG0649	NAD binding
EP757_RS08975	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EP757_RS08980	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EP757_RS09010	COG0739	heme binding
EP757_RS09010	COG1196	nuclear chromosome segregation
EP757_RS09010	COG0741	lytic transglycosylase activity
EP757_RS09040	COG1674	ftsk spoiiie
EP757_RS09055	COG0302	gtp cyclohydrolase
EP757_RS09060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EP757_RS09065	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EP757_RS09070	COG0037	tRNA processing
EP757_RS09080	COG2027	D-alanyl-D-alanine carboxypeptidase
EP757_RS09085	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EP757_RS09095	COG1674	ftsk spoiiie
EP757_RS09115	COG1408	metallophosphoesterase
EP757_RS09120	COG1610	YqeY-like protein
EP757_RS09125	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EP757_RS09135	COG0003	Pfam Anion-transporting ATPase
EP757_RS09160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP757_RS09175	COG4770	biotin carboxylase activity
EP757_RS09200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EP757_RS09220	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EP757_RS09240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EP757_RS09265	COG4608	Belongs to the ABC transporter superfamily
EP757_RS09285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EP757_RS09290	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EP757_RS09295	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EP757_RS09340	COG0813	purine-nucleoside phosphorylase activity
EP757_RS09345	COG0590	tRNA wobble adenosine to inosine editing
EP757_RS09370	COG0287	Prephenate dehydrogenase
EP757_RS09375	COG2318	DinB family
EP757_RS09380	COG0235	Class ii aldolase
EP757_RS09380	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EP757_RS09385	COG1796	DNA polymerase
EP757_RS09385	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EP757_RS09400	COG0642	Histidine kinase
EP757_RS09405	COG2018	Roadblock/LC7 domain
EP757_RS09430	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EP757_RS09435	COG5298	Protein conserved in bacteria
EP757_RS09470	COG0477	Major facilitator Superfamily
EP757_RS09515	COG0778	Nitroreductase
EP757_RS09520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EP757_RS09545	COG3397	chitin binding
EP757_RS09570	COG1268	BioY protein
EP757_RS09600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EP757_RS09610	COG0667	Aldo Keto reductase
EP757_RS09635	COG0673	inositol 2-dehydrogenase activity
EP757_RS09650	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
EP757_RS09655	COG3831	ATPase activity
EP757_RS09680	COG4558	Periplasmic binding protein
EP757_RS09685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EP757_RS09690	COG1120	ATPase activity
EP757_RS09700	COG3903	Transcriptional regulator
EP757_RS09700	COG3629	intracellular signal transduction
EP757_RS09735	COG1216	Glycosyl transferase, family 2
EP757_RS09740	COG0438	transferase activity, transferring glycosyl groups
EP757_RS09750	COG1595	DNA-templated transcription, initiation
EP757_RS09800	COG2208	phosphoserine phosphatase activity
EP757_RS09800	COG2770	Histidine kinase
EP757_RS09810	COG1278	Cold shock
EP757_RS09855	COG0438	transferase activity, transferring glycosyl groups
EP757_RS09870	COG1597	lipid kinase activity
EP757_RS09870	COG1803	Methylglyoxal synthase
EP757_RS09930	COG0419	ATPase involved in DNA repair
EP757_RS09955	COG4974	Belongs to the 'phage' integrase family
EP757_RS09960	COG0494	nUDIX hydrolase
EP757_RS09970	COG2188	Transcriptional regulator
EP757_RS10025	COG0242	peptide deformylase activity
EP757_RS10045	COG1881	PFAM PEBP family protein
EP757_RS10070	COG0789	Transcriptional regulator
EP757_RS10075	COG3959	Transketolase, thiamine diphosphate binding domain
EP757_RS10080	COG3958	Transketolase
EP757_RS10095	COG0705	Rhomboid family
EP757_RS10100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EP757_RS10115	COG0598	Magnesium transport protein CorA
EP757_RS10120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EP757_RS10130	COG0371	Dehydrogenase
EP757_RS10145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EP757_RS10155	COG3275	phosphorelay sensor kinase activity
EP757_RS10165	COG0745	RESPONSE REGULATOR receiver
EP757_RS10170	COG2205	protein histidine kinase activity
EP757_RS10185	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP757_RS10220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP757_RS10255	COG2235	arginine
EP757_RS10295	COG1764	response to oxidative stress
EP757_RS10305	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EP757_RS10310	COG0561	phosphatase activity
EP757_RS10315	COG0561	phosphatase activity
EP757_RS10325	COG1834	amidinotransferase
EP757_RS10350	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EP757_RS10355	COG3540	Alkaline phosphatase
EP757_RS10375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EP757_RS10425	COG0315	cyclic pyranopterin monophosphate synthase activity
EP757_RS10425	COG0521	Mo-molybdopterin cofactor biosynthetic process
EP757_RS10430	COG0315	cyclic pyranopterin monophosphate synthase activity
EP757_RS10435	COG5001	Diguanylate cyclase
EP757_RS10455	COG0305	Participates in initiation and elongation during chromosome replication
EP757_RS10465	COG0359	binds to the 23S rRNA
EP757_RS10470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EP757_RS10475	COG0629	single-stranded DNA binding
EP757_RS10480	COG0360	Binds together with S18 to 16S ribosomal RNA
EP757_RS10505	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EP757_RS10515	COG1695	Transcriptional regulator
EP757_RS10525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EP757_RS10545	COG3409	Peptidoglycan-binding domain 1 protein
EP757_RS10550	COG0617	tRNA 3'-terminal CCA addition
EP757_RS10565	COG2815	serine threonine protein kinase
EP757_RS10565	COG0515	serine threonine protein kinase
EP757_RS10570	COG1595	DNA-templated transcription, initiation
EP757_RS10580	COG0492	ferredoxin-NADP+ reductase activity
EP757_RS10585	COG3118	belongs to the thioredoxin family
EP757_RS10590	COG3409	Peptidoglycan-binding domain 1 protein
EP757_RS10590	COG0860	N-Acetylmuramoyl-L-alanine amidase
EP757_RS10600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EP757_RS10605	COG1181	Belongs to the D-alanine--D-alanine ligase family
EP757_RS10630	COG1192	Involved in chromosome partitioning
EP757_RS10635	COG0357	Ribosomal RNA small subunit methyltransferase G
EP757_RS10645	COG0706	membrane insertase activity
EP757_RS10650	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EP757_RS10655	COG0594	ribonuclease P activity
EP757_RS10660	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EP757_RS10670	COG0592	DNA-directed DNA polymerase activity
EP757_RS10675	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EP757_RS10680	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EP757_RS10685	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
EP757_RS10700	COG0187	DNA topoisomerase II activity
EP757_RS10705	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EP757_RS10730	COG1051	belongs to the nudix hydrolase family
EP757_RS10740	COG2816	NAD+ diphosphatase activity
EP757_RS10755	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EP757_RS10770	COG0442	prolyl-tRNA aminoacylation
EP757_RS10805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EP757_RS10820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EP757_RS10825	COG1960	acyl-CoA dehydrogenase activity
EP757_RS10830	COG1846	Transcriptional regulator
EP757_RS10885	COG1716	ATPase activity
EP757_RS10885	COG1716	ATPase activity
EP757_RS10890	COG1716	ATPase activity
EP757_RS10905	COG0768	penicillin binding
EP757_RS10910	COG0515	serine threonine protein kinase
EP757_RS10915	COG2815	serine threonine protein kinase
EP757_RS10915	COG0515	serine threonine protein kinase
EP757_RS10950	COG2181	nitrate reductase activity
EP757_RS10950	COG0247	lactate metabolic process
EP757_RS10985	COG0717	Belongs to the dCTP deaminase family
EP757_RS10995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EP757_RS11000	COG2770	Histidine kinase
EP757_RS11000	COG2208	phosphoserine phosphatase activity
EP757_RS11005	COG1960	acyl-CoA dehydrogenase activity
EP757_RS11035	COG0588	phosphoglycerate mutase activity
EP757_RS11050	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EP757_RS11055	COG1984	allophanate hydrolase subunit 2
EP757_RS11075	COG0508	dehydrogenase complex catalyzes the overall conversion of
EP757_RS11080	COG0022	dehydrogenase e1 component
EP757_RS11110	COG0443	Heat shock 70 kDa protein
EP757_RS11115	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EP757_RS11120	COG0484	heat shock protein binding
EP757_RS11125	COG0789	Transcriptional regulator
EP757_RS11145	COG2814	Major facilitator Superfamily
EP757_RS11150	COG0542	response to heat
EP757_RS11170	COG0640	Transcriptional regulator
EP757_RS11180	COG0586	Pfam SNARE associated Golgi protein
EP757_RS11185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EP757_RS11245	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EP757_RS11250	COG0151	Belongs to the GarS family
EP757_RS11260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EP757_RS11270	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EP757_RS11275	COG0047	phosphoribosylformylglycinamidine synthase activity
EP757_RS11280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EP757_RS11300	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EP757_RS11305	COG0641	radical SAM
EP757_RS11340	COG2226	methyltransferase
EP757_RS11345	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
EP757_RS11365	COG2050	protein possibly involved in aromatic compounds catabolism
EP757_RS11425	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EP757_RS11435	COG0142	geranyltranstransferase activity
EP757_RS11450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP757_RS11485	COG0438	transferase activity, transferring glycosyl groups
EP757_RS11510	COG1970	mechanosensitive ion channel activity
EP757_RS11520	COG1366	Belongs to the anti-sigma-factor antagonist family
EP757_RS11525	COG1366	Belongs to the anti-sigma-factor antagonist family
EP757_RS11530	COG2172	sigma factor antagonist activity
EP757_RS11540	COG2205	protein histidine kinase activity
EP757_RS11540	COG0784	Response regulator, receiver
EP757_RS11545	COG0745	RESPONSE REGULATOR receiver
EP757_RS11555	COG1136	(ABC) transporter
EP757_RS11575	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EP757_RS11580	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EP757_RS11590	COG2205	protein histidine kinase activity
EP757_RS11590	COG0784	Response regulator, receiver
EP757_RS11595	COG0745	RESPONSE REGULATOR receiver
EP757_RS11610	COG1366	Belongs to the anti-sigma-factor antagonist family
EP757_RS11615	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EP757_RS11620	COG0406	alpha-ribazole phosphatase activity
EP757_RS11625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EP757_RS11640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EP757_RS11650	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EP757_RS11655	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EP757_RS11660	COG1595	DNA-templated transcription, initiation
EP757_RS11670	COG0163	prenyltransferase activity
EP757_RS11690	COG0513	Belongs to the DEAD box helicase family
EP757_RS11700	COG0791	NLP P60 protein
EP757_RS11705	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EP757_RS11730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EP757_RS11735	COG1120	ATPase activity
EP757_RS11740	COG1987	bacterial-type flagellum assembly
EP757_RS11765	COG3973	AAA domain
EP757_RS11780	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
EP757_RS11785	COG0667	Aldo Keto reductase
EP757_RS11790	COG4279	zinc finger
EP757_RS11795	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EP757_RS11800	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EP757_RS11805	COG2226	methyltransferase
EP757_RS11825	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EP757_RS11830	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EP757_RS11835	COG0649	NAD binding
EP757_RS11850	COG1034	ATP synthesis coupled electron transport
EP757_RS11855	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EP757_RS11860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EP757_RS11870	COG0713	ATP synthesis coupled electron transport
EP757_RS11885	COG1007	ATP synthesis coupled electron transport
EP757_RS11895	COG0142	geranyltranstransferase activity
EP757_RS11920	COG1950	PFAM Membrane protein of
EP757_RS11955	COG0596	Alpha beta hydrolase
EP757_RS11980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EP757_RS12040	COG1111	helicase
EP757_RS12040	COG1205	dead DEAH box helicase
EP757_RS12045	COG1366	Belongs to the anti-sigma-factor antagonist family
EP757_RS12055	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EP757_RS12070	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EP757_RS12070	COG1754	DNA topoisomerase type I activity
EP757_RS12080	COG1309	transcriptional regulator
EP757_RS12090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EP757_RS12095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EP757_RS12120	COG1774	PSP1 C-terminal conserved region
EP757_RS12135	COG3594	Acyltransferase
EP757_RS12145	COG0693	protein deglycase activity
EP757_RS12180	COG0644	oxidoreductase
EP757_RS12195	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
EP757_RS12205	COG3285	dna ligase
EP757_RS12205	COG1793	dna ligase
EP757_RS12220	COG0133	tryptophan synthase activity
EP757_RS12225	COG0159	tryptophan synthase activity
EP757_RS12230	COG2188	Transcriptional regulator
EP757_RS12235	COG1061	Type III restriction enzyme res subunit
EP757_RS12250	COG0546	phosphoglycolate phosphatase activity
EP757_RS12255	COG1278	Cold shock
EP757_RS12260	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
EP757_RS12275	COG2723	6-phospho-beta-galactosidase activity
EP757_RS12290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EP757_RS12295	COG2814	Major facilitator Superfamily
EP757_RS12310	COG2252	PERMEase
EP757_RS12350	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EP757_RS12360	COG0259	pyridoxamine-phosphate oxidase activity
EP757_RS12370	COG2017	converts alpha-aldose to the beta-anomer
EP757_RS12400	COG3842	ATPase activity
EP757_RS12430	COG1388	LysM domain
EP757_RS12430	COG1134	teichoic acid transport
EP757_RS12440	COG1309	transcriptional regulator
EP757_RS12485	COG0604	alcohol dehydrogenase
EP757_RS12495	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
EP757_RS12510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EP757_RS12515	COG1086	Polysaccharide biosynthesis protein
EP757_RS12530	COG0318	PFAM AMP-dependent synthetase and ligase
EP757_RS12555	COG2197	response regulator
EP757_RS12575	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EP757_RS12580	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EP757_RS12600	COG2089	acid synthase
EP757_RS12610	COG1216	Glycosyl transferase, family 2
EP757_RS12615	COG5001	Diguanylate cyclase
EP757_RS12615	COG3300	MHYT domain
EP757_RS12635	COG2814	Major facilitator Superfamily
EP757_RS12655	COG2119	membrane
EP757_RS12705	COG0586	Pfam SNARE associated Golgi protein
EP757_RS12710	COG1191	sigma factor activity
EP757_RS12735	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EP757_RS12775	COG1309	transcriptional regulator
EP757_RS12780	COG1131	(ABC) transporter
EP757_RS12785	COG3559	Exporter of polyketide antibiotics
EP757_RS12790	COG0025	NhaP-type Na H and K H
EP757_RS12800	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EP757_RS12820	COG1088	dTDP-glucose 4,6-dehydratase activity
EP757_RS12830	COG2814	Major facilitator Superfamily
EP757_RS12835	COG0673	inositol 2-dehydrogenase activity
EP757_RS12885	COG3268	Saccharopine dehydrogenase
EP757_RS12890	COG1652	LysM domain
EP757_RS12900	COG0583	DNA-binding transcription factor activity
EP757_RS12925	COG1686	Belongs to the peptidase S11 family
EP757_RS12930	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EP757_RS12935	COG2188	Transcriptional regulator
EP757_RS12940	COG0737	Belongs to the 5'-nucleotidase family
EP757_RS12955	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EP757_RS12955	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EP757_RS12960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EP757_RS12965	COG2205	protein histidine kinase activity
EP757_RS12970	COG0745	RESPONSE REGULATOR receiver
EP757_RS12985	COG1193	negative regulation of DNA recombination
EP757_RS13000	COG0745	RESPONSE REGULATOR receiver
EP757_RS13005	COG4251	negative regulation of phosphorylation
EP757_RS13010	COG0784	Response regulator, receiver
EP757_RS13015	COG0483	inositol monophosphate 1-phosphatase activity
EP757_RS13020	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS13040	COG0515	serine threonine protein kinase
EP757_RS13040	COG2815	serine threonine protein kinase
EP757_RS13045	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS13065	COG2217	Heavy metal translocating P-type atpase
EP757_RS13085	COG0513	Belongs to the DEAD box helicase family
EP757_RS13130	COG0438	transferase activity, transferring glycosyl groups
EP757_RS13130	COG1216	Glycosyl transferase, family 2
EP757_RS13145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EP757_RS13150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EP757_RS13160	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EP757_RS13185	COG2211	Major facilitator Superfamily
EP757_RS13195	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EP757_RS13200	COG0181	hydroxymethylbilane synthase activity
EP757_RS13230	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EP757_RS13235	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EP757_RS13255	COG0713	ATP synthesis coupled electron transport
EP757_RS13260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EP757_RS13270	COG1007	ATP synthesis coupled electron transport
EP757_RS13280	COG1595	DNA-templated transcription, initiation
EP757_RS13295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS13300	COG0501	Belongs to the peptidase M48B family
EP757_RS13315	COG1666	GTP binding
EP757_RS13335	COG5001	Diguanylate cyclase
EP757_RS13335	COG3300	MHYT domain
EP757_RS13350	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EP757_RS13355	COG2030	dehydratase
EP757_RS13380	COG0081	regulation of translation
EP757_RS13395	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EP757_RS13400	COG0222	ribosome binding
EP757_RS13405	COG0085	RNA polymerase activity
EP757_RS13410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EP757_RS13425	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EP757_RS13430	COG0049	tRNA binding
EP757_RS13435	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EP757_RS13440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EP757_RS13445	COG0051	transcription antitermination factor activity, RNA binding
EP757_RS13450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EP757_RS13455	COG0088	Forms part of the polypeptide exit tunnel
EP757_RS13460	COG0089	rRNA binding
EP757_RS13465	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EP757_RS13470	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EP757_RS13475	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EP757_RS13480	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EP757_RS13485	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EP757_RS13490	COG0255	Belongs to the universal ribosomal protein uL29 family
EP757_RS13495	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EP757_RS13500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EP757_RS13505	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EP757_RS13510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EP757_RS13515	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EP757_RS13520	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EP757_RS13525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EP757_RS13530	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EP757_RS13535	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EP757_RS13540	COG1841	ribosomal large subunit assembly
EP757_RS13545	COG0200	Binds to the 23S rRNA
EP757_RS13555	COG0563	adenylate kinase activity
EP757_RS13570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EP757_RS13575	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EP757_RS13580	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EP757_RS13585	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EP757_RS13590	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EP757_RS13600	COG0203	ribosomal protein L17
EP757_RS13605	COG0101	tRNA pseudouridine synthase activity
EP757_RS13620	COG0488	(ABC) transporter
EP757_RS13625	COG0352	thiamine-phosphate diphosphorylase activity
EP757_RS13630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EP757_RS13630	COG2022	thiamine diphosphate biosynthetic process
EP757_RS13640	COG2022	thiamine diphosphate biosynthetic process
EP757_RS13645	COG0352	thiamine-phosphate diphosphorylase activity
EP757_RS13650	COG0351	phosphomethylpyrimidine kinase
EP757_RS13655	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EP757_RS13680	COG2205	protein histidine kinase activity
EP757_RS13685	COG2018	Roadblock/LC7 domain
EP757_RS13710	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EP757_RS13715	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EP757_RS13720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EP757_RS13735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EP757_RS13750	COG0736	holo-[acyl-carrier-protein] synthase activity
EP757_RS13770	COG0802	atpase or kinase
EP757_RS13775	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EP757_RS13780	COG0456	acetyltransferase
EP757_RS13780	COG1214	PFAM Peptidase M22, glycoprotease
EP757_RS13790	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EP757_RS13805	COG1132	(ABC) transporter
EP757_RS13810	COG0459	protein refolding
EP757_RS13815	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EP757_RS13825	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EP757_RS13840	COG4214	carbohydrate transport
EP757_RS13875	COG2197	response regulator
EP757_RS13890	COG0516	GMP reductase activity
EP757_RS13900	COG1316	TRANSCRIPTIONal
EP757_RS13905	COG1404	Belongs to the peptidase S8 family
EP757_RS13910	COG0519	Catalyzes the synthesis of GMP from XMP
EP757_RS13910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EP757_RS13925	COG1183	phosphatidylcholine synthase activity
EP757_RS13930	COG0688	phosphatidylethanolamine metabolic process
EP757_RS13945	COG4585	Histidine kinase
EP757_RS13950	COG2197	response regulator
EP757_RS13955	COG4166	transmembrane transport
EP757_RS13960	COG0601	transmembrane transport
EP757_RS13965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EP757_RS13970	COG0444	Belongs to the ABC transporter superfamily
EP757_RS13975	COG4608	Belongs to the ABC transporter superfamily
EP757_RS13980	COG1605	Chorismate mutase
EP757_RS13985	COG0737	Belongs to the 5'-nucleotidase family
EP757_RS13985	COG4085	toxin activity
EP757_RS13985	COG1525	nuclease
EP757_RS13995	COG1196	nuclear chromosome segregation
EP757_RS13995	COG0739	heme binding
EP757_RS13995	COG0741	lytic transglycosylase activity
EP757_RS14005	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EP757_RS14010	COG0045	succinate-CoA ligase (ADP-forming) activity
EP757_RS14035	COG0138	bifunctional purine biosynthesis protein purh
EP757_RS14045	COG0538	isocitrate dehydrogenase activity
EP757_RS14060	COG1349	DNA-binding transcription factor activity
EP757_RS14120	COG0529	Catalyzes the synthesis of activated sulfate
EP757_RS14130	COG1131	(ABC) transporter
EP757_RS14150	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EP757_RS14170	COG1024	Enoyl-CoA hydratase
EP757_RS14170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EP757_RS14230	COG0148	phosphopyruvate hydratase activity
EP757_RS14245	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EP757_RS14285	COG0714	Associated with various cellular activities
EP757_RS14320	COG0183	Belongs to the thiolase family
EP757_RS14325	COG2755	lipolytic protein G-D-S-L family
EP757_RS14370	COG2326	polyphosphate kinase activity
EP757_RS14375	COG1234	tRNA 3'-trailer cleavage
EP757_RS14430	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EP757_RS14435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EP757_RS14445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EP757_RS14470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EP757_RS14475	COG1331	Highly conserved protein containing a thioredoxin domain
EP757_RS14560	COG1473	amidohydrolase
EP757_RS14565	COG0477	Major facilitator Superfamily
EP757_RS14580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EP757_RS14590	COG0438	transferase activity, transferring glycosyl groups
EP757_RS14605	COG0778	Nitroreductase
EP757_RS14605	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
EP757_RS14610	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EP757_RS14620	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EP757_RS14640	COG0726	polysaccharide deacetylase
EP757_RS14650	COG1012	belongs to the aldehyde dehydrogenase family
EP757_RS14660	COG1515	deoxyribonuclease V activity
EP757_RS14665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EP757_RS14670	COG2835	tetraacyldisaccharide 4'-kinase activity
EP757_RS14690	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EP757_RS14705	COG0745	RESPONSE REGULATOR receiver
EP757_RS14710	COG5002	protein histidine kinase activity
EP757_RS14725	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EP757_RS14730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EP757_RS14735	COG0653	protein targeting
EP757_RS14760	COG1012	belongs to the aldehyde dehydrogenase family
EP757_RS14770	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EP757_RS14775	COG2884	Cell division ATP-binding protein ftsE
EP757_RS14780	COG2177	Part of the ABC transporter FtsEX involved in
EP757_RS14785	COG0739	heme binding
EP757_RS14790	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EP757_RS14815	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EP757_RS14820	COG1678	Uncharacterized ACR, COG1678
EP757_RS14855	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EP757_RS14865	COG1459	type II secretion system
EP757_RS14875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EP757_RS14890	COG1366	Belongs to the anti-sigma-factor antagonist family
EP757_RS14990	COG5001	Diguanylate cyclase
EP757_RS14990	COG5002	protein histidine kinase activity
EP757_RS15015	COG3285	dna ligase
EP757_RS15015	COG1793	dna ligase
EP757_RS15020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP757_RS15025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EP757_RS15050	COG1335	isochorismatase
EP757_RS15055	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EP757_RS15090	COG1234	tRNA 3'-trailer cleavage
EP757_RS15095	COG0438	transferase activity, transferring glycosyl groups
EP757_RS15100	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EP757_RS15105	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EP757_RS15115	COG1228	amidohydrolase
EP757_RS15130	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EP757_RS15195	COG2372	response to copper ion
EP757_RS15195	COG1276	copper resistance
EP757_RS15210	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EP757_RS15220	COG5297	Belongs to the glycosyl hydrolase family 6
EP757_RS15240	COG3226	Transcriptional regulator
EP757_RS15250	COG1376	ErfK ybiS ycfS ynhG family protein
EP757_RS15255	COG1376	ErfK ybiS ycfS ynhG family protein
EP757_RS15270	COG3012	SEC-C Motif Domain Protein
EP757_RS15270	COG3318	Belongs to the UPF0149 family
EP757_RS15285	COG0431	NADPH-dependent FMN reductase
EP757_RS15290	COG3119	arylsulfatase activity
EP757_RS15295	COG2124	cytochrome p450
EP757_RS15310	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS15325	COG5001	Diguanylate cyclase
EP757_RS15325	COG3300	MHYT domain
EP757_RS15370	COG1472	Belongs to the glycosyl hydrolase 3 family
EP757_RS15385	COG4209	transmembrane transport
EP757_RS15390	COG0395	ABC-type sugar transport system, permease component
EP757_RS15400	COG4977	sequence-specific DNA binding
EP757_RS15415	COG0277	FAD linked oxidase domain protein
EP757_RS15425	COG0745	RESPONSE REGULATOR receiver
EP757_RS15465	COG0456	acetyltransferase
EP757_RS15480	COG2124	cytochrome p450
EP757_RS15525	COG3903	Transcriptional regulator
EP757_RS15525	COG3629	intracellular signal transduction
EP757_RS15535	COG1609	Transcriptional regulator
EP757_RS15540	COG2706	6-phosphogluconolactonase activity
EP757_RS15550	COG1940	carbohydrate kinase activity
EP757_RS15555	COG2115	Belongs to the xylose isomerase family
EP757_RS15560	COG1070	Carbohydrate kinase
EP757_RS15585	COG0366	Alpha amylase catalytic
EP757_RS15590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EP757_RS15615	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EP757_RS15630	COG3103	Sh3 type 3 domain protein
EP757_RS15630	COG1388	LysM domain
EP757_RS15630	COG0791	NLP P60 protein
EP757_RS15635	COG2814	Major facilitator Superfamily
EP757_RS15680	COG2264	protein methyltransferase activity
EP757_RS15705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EP757_RS15730	COG0577	efflux transmembrane transporter activity
EP757_RS15735	COG0577	efflux transmembrane transporter activity
EP757_RS15735	COG1136	(ABC) transporter
EP757_RS15750	COG0745	RESPONSE REGULATOR receiver
EP757_RS15755	COG2205	protein histidine kinase activity
EP757_RS15810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EP757_RS15830	COG0629	single-stranded DNA binding
EP757_RS15840	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EP757_RS15845	COG1492	cobalamin metabolic process
EP757_RS15850	COG0501	Belongs to the peptidase M48B family
EP757_RS15870	COG1793	dna ligase
EP757_RS15885	COG1797	cobyrinic acid a,c-diamide synthase activity
EP757_RS15905	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EP757_RS15910	COG1648	precorrin-2 dehydrogenase activity
EP757_RS15910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EP757_RS15915	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EP757_RS15960	COG0668	transmembrane transport
EP757_RS15985	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
EP757_RS16000	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EP757_RS16015	COG0698	ribose 5-phosphate isomerase
EP757_RS16030	COG4552	Acetyltransferase involved in intracellular survival and related
EP757_RS16040	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS16045	COG0463	Glycosyl transferase, family 2
EP757_RS16055	COG0640	Transcriptional regulator
EP757_RS16070	COG0544	peptidyl-prolyl cis-trans isomerase activity
EP757_RS16080	COG0740	serine-type endopeptidase activity
EP757_RS16085	COG0740	serine-type endopeptidase activity
EP757_RS16090	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EP757_RS16125	COG0525	valine-tRNA ligase activity
EP757_RS16130	COG0285	dihydrofolate synthase activity
EP757_RS16145	COG0105	UTP biosynthetic process
EP757_RS16160	COG1131	(ABC) transporter
EP757_RS16170	COG0840	transmembrane signaling receptor activity
EP757_RS16175	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EP757_RS16190	COG0596	Alpha beta hydrolase
EP757_RS16195	COG2172	sigma factor antagonist activity
EP757_RS16195	COG1366	Belongs to the anti-sigma-factor antagonist family
EP757_RS16195	COG2208	phosphoserine phosphatase activity
EP757_RS16200	COG1366	Belongs to the anti-sigma-factor antagonist family
EP757_RS16215	COG1530	ribonuclease E activity
EP757_RS16225	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EP757_RS16230	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EP757_RS16235	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EP757_RS16245	COG0180	Tryptophanyl-tRNA synthetase
EP757_RS16260	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EP757_RS16270	COG0406	alpha-ribazole phosphatase activity
EP757_RS16280	COG1307	EDD domain protein, DegV family
EP757_RS16290	COG2890	protein-(glutamine-N5) methyltransferase activity
EP757_RS16300	COG0658	competence protein
EP757_RS16300	COG2333	competence protein COMEC
EP757_RS16315	COG0268	Binds directly to 16S ribosomal RNA
EP757_RS16335	COG0481	GTPase activity
EP757_RS16340	COG2261	transglycosylase associated protein
EP757_RS16355	COG1024	Enoyl-CoA hydratase
EP757_RS16370	COG1420	regulation of RNA biosynthetic process
EP757_RS16375	COG0484	heat shock protein binding
EP757_RS16380	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EP757_RS16390	COG0537	adenosine 5'-monophosphoramidase activity
EP757_RS16405	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EP757_RS16420	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EP757_RS16435	COG1381	Involved in DNA repair and RecF pathway recombination
EP757_RS16440	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EP757_RS16495	COG4172	Belongs to the ABC transporter superfamily
EP757_RS16500	COG4721	ABC-type cobalt transport system, permease component
EP757_RS16505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EP757_RS16535	COG1121	(ABC) transporter
EP757_RS16540	COG3443	Belongs to the bacterial solute-binding protein 9 family
EP757_RS16540	COG0803	Belongs to the bacterial solute-binding protein 9 family
EP757_RS16560	COG0423	glycine-tRNA ligase activity
EP757_RS16565	COG3608	succinylglutamate desuccinylase aspartoacylase
EP757_RS16565	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EP757_RS16580	COG4585	Histidine kinase
EP757_RS16585	COG2197	response regulator
EP757_RS16605	COG2018	Roadblock/LC7 domain
EP757_RS16630	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EP757_RS16645	COG1131	(ABC) transporter
EP757_RS16660	COG1295	ribonuclease BN
EP757_RS16665	COG1940	carbohydrate kinase activity
EP757_RS16665	COG1846	Transcriptional regulator
EP757_RS16670	COG1129	ABC transporter
EP757_RS16675	COG1172	Belongs to the binding-protein-dependent transport system permease family
EP757_RS16730	COG4115	mRNA cleavage
EP757_RS16780	COG0559	Belongs to the binding-protein-dependent transport system permease family
EP757_RS16805	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS16810	COG0789	Transcriptional regulator
EP757_RS16820	COG1957	nucleoside hydrolase
EP757_RS16830	COG0698	ribose 5-phosphate isomerase
EP757_RS16840	COG3831	ATPase activity
EP757_RS16845	COG1505	serine-type exopeptidase activity
EP757_RS16910	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EP757_RS16915	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EP757_RS16920	COG1414	Transcriptional regulator
EP757_RS16925	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EP757_RS16940	COG1192	Involved in chromosome partitioning
EP757_RS16960	COG3979	chitinase
EP757_RS17010	COG0018	arginyl-trna synthetase
EP757_RS17015	COG0737	Belongs to the 5'-nucleotidase family
EP757_RS17025	COG0515	serine threonine protein kinase
EP757_RS17040	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EP757_RS17045	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EP757_RS17045	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EP757_RS17065	COG3973	AAA domain
EP757_RS17090	COG1472	Belongs to the glycosyl hydrolase 3 family
EP757_RS17105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EP757_RS17110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EP757_RS17140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EP757_RS17145	COG0840	transmembrane signaling receptor activity
EP757_RS17150	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EP757_RS17155	COG0432	Pfam Uncharacterised protein family UPF0047
EP757_RS17200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EP757_RS17240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EP757_RS17250	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EP757_RS17260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EP757_RS17270	COG0730	response to heat
EP757_RS17295	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
EP757_RS17305	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EP757_RS17310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EP757_RS17310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EP757_RS17315	COG0174	glutamine synthetase
EP757_RS17325	COG1595	DNA-templated transcription, initiation
EP757_RS17330	COG3766	membrane
EP757_RS17340	COG1064	alcohol dehydrogenase
EP757_RS17350	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EP757_RS17360	COG1846	Transcriptional regulator
EP757_RS17440	COG1674	ftsk spoiiie
EP757_RS17470	COG1672	PFAM Archaeal ATPase
EP757_RS17470	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EP757_RS17480	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EP757_RS17490	COG0017	Asparaginyl-tRNA synthetase
EP757_RS17500	COG0321	lipoyl(octanoyl) transferase activity
EP757_RS17510	COG1090	epimerase
EP757_RS17515	COG0508	dehydrogenase complex catalyzes the overall conversion of
EP757_RS17520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP757_RS17530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EP757_RS17535	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EP757_RS17540	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EP757_RS17555	COG1994	Peptidase M50
EP757_RS17560	COG0667	Aldo Keto reductase
EP757_RS17580	COG4555	ABC transporter
EP757_RS17585	COG1396	sequence-specific DNA binding
EP757_RS17590	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EP757_RS17605	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EP757_RS17610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EP757_RS17615	COG1929	Belongs to the glycerate kinase type-1 family
EP757_RS17625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP757_RS17635	COG0425	Belongs to the sulfur carrier protein TusA family
EP757_RS17640	COG1104	cysteine desulfurase activity
EP757_RS17645	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EP757_RS17660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EP757_RS17675	COG1845	cytochrome c oxidase, subunit III
EP757_RS17690	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EP757_RS17705	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EP757_RS17715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EP757_RS17735	COG0501	Belongs to the peptidase M48B family
EP757_RS17740	COG0438	transferase activity, transferring glycosyl groups
EP757_RS17745	COG1132	(ABC) transporter
EP757_RS17770	COG2197	response regulator
EP757_RS17790	COG1940	carbohydrate kinase activity
EP757_RS17800	COG2072	flavoprotein involved in K transport
EP757_RS17820	COG0204	Acyl-transferase
EP757_RS17860	COG2211	Major facilitator Superfamily
EP757_RS17875	COG0205	6-phosphofructokinase activity
EP757_RS17925	COG0386	Belongs to the glutathione peroxidase family
EP757_RS17935	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EP757_RS17955	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EP757_RS17960	COG0515	serine threonine protein kinase
EP757_RS17960	COG2815	serine threonine protein kinase
EP757_RS17975	COG0142	geranyltranstransferase activity
EP757_RS18015	COG1309	transcriptional regulator
EP757_RS18025	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EP757_RS18030	COG1053	succinate dehydrogenase
EP757_RS18040	COG0583	DNA-binding transcription factor activity
EP757_RS18045	COG2226	methyltransferase
EP757_RS18055	COG1233	COG1233 Phytoene dehydrogenase and related
EP757_RS18115	COG0587	DNA-directed DNA polymerase activity
EP757_RS18150	COG0714	Associated with various cellular activities
EP757_RS18155	COG0495	leucyl-tRNA aminoacylation
EP757_RS18165	COG3442	glutamine amidotransferase
EP757_RS18180	COG2001	Belongs to the MraZ family
EP757_RS18185	COG0275	rRNA processing
EP757_RS18195	COG0768	penicillin binding
EP757_RS18200	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EP757_RS18210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EP757_RS18220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EP757_RS18225	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EP757_RS18230	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EP757_RS18235	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EP757_RS18240	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EP757_RS18245	COG1799	cell septum assembly
EP757_RS18275	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EP757_RS18295	COG0587	DNA-directed DNA polymerase activity
EP757_RS18305	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EP757_RS18310	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EP757_RS18315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP757_RS18320	COG0131	Imidazoleglycerol-phosphate dehydratase
EP757_RS18335	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EP757_RS18340	COG0583	DNA-binding transcription factor activity
EP757_RS18350	COG0107	imidazoleglycerol-phosphate synthase activity
EP757_RS18355	COG3550	peptidyl-serine autophosphorylation
EP757_RS18375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EP757_RS18385	COG1022	Amp-dependent synthetase and ligase
EP757_RS18395	COG0531	amino acid
EP757_RS18405	COG1132	(ABC) transporter
EP757_RS18410	COG1132	(ABC) transporter
EP757_RS18415	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EP757_RS18430	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EP757_RS18450	COG0134	indole-3-glycerol-phosphate synthase activity
EP757_RS18455	COG0133	tryptophan synthase activity
EP757_RS18460	COG0159	tryptophan synthase activity
EP757_RS18465	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EP757_RS18480	COG0070	glutamate synthase
EP757_RS18480	COG0069	glutamate synthase activity
EP757_RS18480	COG0067	glutamate synthase
EP757_RS18495	COG1946	Acyl-CoA thioesterase
EP757_RS18515	COG0559	Belongs to the binding-protein-dependent transport system permease family
EP757_RS18545	COG0640	Transcriptional regulator
EP757_RS18560	COG2226	methyltransferase
EP757_RS18565	COG0539	negative regulation of cytoplasmic translation
EP757_RS18570	COG0237	dephospho-CoA kinase activity
EP757_RS18570	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EP757_RS18580	COG2329	Antibiotic biosynthesis monooxygenase
EP757_RS18590	COG1217	gtp-binding protein TYPA
EP757_RS18600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EP757_RS18605	COG0740	serine-type endopeptidase activity
EP757_RS18635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP757_RS18645	COG1162	GTPase activity
EP757_RS18655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EP757_RS18665	COG0322	excinuclease ABC activity
EP757_RS18670	COG1660	Displays ATPase and GTPase activities
EP757_RS18680	COG1481	regulation of sporulation
EP757_RS18685	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EP757_RS18690	COG0126	phosphoglycerate kinase activity
EP757_RS18695	COG0149	triose-phosphate isomerase activity
EP757_RS18700	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EP757_RS18715	COG0363	glucosamine-6-phosphate deaminase activity
EP757_RS18730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EP757_RS18740	COG0109	protoheme IX farnesyltransferase activity
EP757_RS18760	COG1612	heme a metabolic process
EP757_RS18785	COG0396	ATPase activity
EP757_RS18790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EP757_RS18795	COG0822	iron-sulfur transferase activity
EP757_RS18800	COG2151	metal-sulfur cluster biosynthetic enzyme
EP757_RS18810	COG2267	carboxylic ester hydrolase activity
EP757_RS18850	COG0488	(ABC) transporter
EP757_RS18865	COG1132	(ABC) transporter
EP757_RS18875	COG3663	DNA glycosylase
EP757_RS18880	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS18905	COG1473	amidohydrolase
EP757_RS18915	COG1674	ftsk spoiiie
EP757_RS19060	COG1309	transcriptional regulator
EP757_RS19110	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EP757_RS19135	COG3629	intracellular signal transduction
EP757_RS19135	COG3903	Transcriptional regulator
EP757_RS19140	COG0006	proline dipeptidase activity
EP757_RS19175	COG0714	Associated with various cellular activities
EP757_RS19190	COG2197	response regulator
EP757_RS19195	COG4585	Histidine kinase
EP757_RS19200	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS19205	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EP757_RS19210	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EP757_RS19250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EP757_RS19300	COG0745	RESPONSE REGULATOR receiver
EP757_RS19305	COG2205	protein histidine kinase activity
EP757_RS19315	COG2111	Na H antiporter
EP757_RS19315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EP757_RS19320	COG1006	Multisubunit Na H antiporter MnhC subunit
EP757_RS19325	COG0651	ATP synthesis coupled electron transport
EP757_RS19335	COG2212	antiporter activity
EP757_RS19340	COG1320	monovalent cation:proton antiporter activity
EP757_RS19345	COG3328	transposase activity
EP757_RS19370	COG1365	unkown
EP757_RS19375	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EP757_RS19390	COG1175	transmembrane transport
EP757_RS19395	COG0395	ABC-type sugar transport system, permease component
EP757_RS19400	COG1653	transport
EP757_RS19405	COG1175	transmembrane transport
EP757_RS19410	COG0395	ABC-type sugar transport system, permease component
EP757_RS19435	COG4585	Histidine kinase
EP757_RS19440	COG2197	response regulator
EP757_RS19520	COG2261	transglycosylase associated protein
EP757_RS19535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EP757_RS19540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EP757_RS19550	COG1309	transcriptional regulator
EP757_RS19565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EP757_RS19595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EP757_RS19600	COG0515	serine threonine protein kinase
EP757_RS19625	COG2200	EAL domain
EP757_RS19625	COG2203	Gaf domain
EP757_RS19625	COG2199	diguanylate cyclase activity
EP757_RS19635	COG1053	succinate dehydrogenase
EP757_RS19640	COG1253	flavin adenine dinucleotide binding
EP757_RS19655	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EP757_RS19660	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EP757_RS19665	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EP757_RS19675	COG3158	transport of potassium into the cell
EP757_RS19690	COG0840	transmembrane signaling receptor activity
EP757_RS19715	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS19735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EP757_RS19740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EP757_RS19745	COG1116	anion transmembrane transporter activity
EP757_RS19775	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EP757_RS19775	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EP757_RS19780	COG0395	ABC-type sugar transport system, permease component
EP757_RS19785	COG1175	transmembrane transport
EP757_RS19790	COG1653	transport
EP757_RS19800	COG4251	negative regulation of phosphorylation
EP757_RS19810	COG1252	NADH dehydrogenase
EP757_RS19820	COG5002	protein histidine kinase activity
EP757_RS19825	COG2205	protein histidine kinase activity
EP757_RS19830	COG2200	EAL domain
EP757_RS19830	COG2199	diguanylate cyclase activity
EP757_RS19830	COG2203	Gaf domain
EP757_RS19840	COG5002	protein histidine kinase activity
EP757_RS19845	COG4251	negative regulation of phosphorylation
EP757_RS19850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP757_RS19860	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EP757_RS19875	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EP757_RS19910	COG0628	permease
EP757_RS19945	COG2197	response regulator
EP757_RS19955	COG2197	response regulator
EP757_RS19995	COG0477	Major facilitator Superfamily
EP757_RS20030	COG2326	polyphosphate kinase activity
EP757_RS20040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP757_RS20065	COG1132	(ABC) transporter
EP757_RS20070	COG1132	(ABC) transporter
EP757_RS20075	COG2197	response regulator
EP757_RS20090	COG0477	Major facilitator Superfamily
EP757_RS20110	COG0531	amino acid
EP757_RS20130	COG5002	protein histidine kinase activity
EP757_RS20170	COG0745	RESPONSE REGULATOR receiver
EP757_RS20245	COG2755	lipolytic protein G-D-S-L family
EP757_RS20255	COG0387	Pfam Sodium calcium exchanger
EP757_RS20260	COG2813	Specifically methylates the guanine in position
EP757_RS20265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EP757_RS20270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EP757_RS20290	COG0701	Predicted permease
EP757_RS20315	COG0730	response to heat
EP757_RS20345	COG2720	vancomycin resistance protein
EP757_RS20355	COG0784	Response regulator, receiver
EP757_RS20355	COG2205	protein histidine kinase activity
EP757_RS20355	COG5002	protein histidine kinase activity
EP757_RS20380	COG2197	response regulator
EP757_RS20385	COG0366	Alpha amylase catalytic
EP757_RS20410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP757_RS20440	COG3328	transposase activity
EP757_RS20460	COG0641	radical SAM
EP757_RS20480	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EP757_RS20495	COG0297	glycogen (starch) synthase activity
EP757_RS20505	COG4981	capsule polysaccharide biosynthetic process
EP757_RS20515	COG0243	molybdopterin cofactor binding
EP757_RS20550	COG4677	pectinesterase activity
EP757_RS20565	COG1053	succinate dehydrogenase
EP757_RS20575	COG1309	transcriptional regulator
EP757_RS20580	COG1960	acyl-CoA dehydrogenase activity
EP757_RS20585	COG1960	acyl-CoA dehydrogenase activity
EP757_RS20605	COG2910	NAD(P)H-binding
EP757_RS20615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EP757_RS20635	COG1053	succinate dehydrogenase
EP757_RS20655	COG1960	acyl-CoA dehydrogenase activity
EP757_RS20660	COG2267	carboxylic ester hydrolase activity
EP757_RS20665	COG0346	lactoylglutathione lyase activity
EP757_RS20670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EP757_RS20675	COG1960	acyl-CoA dehydrogenase activity
EP757_RS20680	COG1960	acyl-CoA dehydrogenase activity
EP757_RS20685	COG1960	acyl-CoA dehydrogenase activity
EP757_RS20690	COG1024	Enoyl-CoA hydratase
EP757_RS20695	COG0318	PFAM AMP-dependent synthetase and ligase
EP757_RS20700	COG1960	acyl-CoA dehydrogenase activity
EP757_RS20705	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS20715	COG0183	Belongs to the thiolase family
EP757_RS20720	COG2124	cytochrome p450
EP757_RS20725	COG3903	Transcriptional regulator
EP757_RS20725	COG3629	intracellular signal transduction
EP757_RS20765	COG1132	(ABC) transporter
EP757_RS20770	COG2070	2-Nitropropane dioxygenase
EP757_RS20795	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS20815	COG1960	acyl-CoA dehydrogenase activity
EP757_RS20820	COG1960	acyl-CoA dehydrogenase activity
EP757_RS20825	COG0183	Belongs to the thiolase family
EP757_RS20850	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS20855	COG1012	belongs to the aldehyde dehydrogenase family
EP757_RS20865	COG1309	transcriptional regulator
EP757_RS20890	COG1309	transcriptional regulator
EP757_RS20895	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EP757_RS20900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS20950	COG0667	Aldo Keto reductase
EP757_RS20960	COG1131	(ABC) transporter
EP757_RS20970	COG4585	Histidine kinase
EP757_RS20975	COG2197	response regulator
EP757_RS21030	COG3459	Glycosyltransferase 36 associated
EP757_RS21075	COG3599	regulation of cell shape
EP757_RS21095	COG0277	FAD linked oxidase domain protein
EP757_RS21100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP757_RS21110	COG1132	(ABC) transporter
EP757_RS21115	COG1132	(ABC) transporter
EP757_RS21135	COG1309	transcriptional regulator
EP757_RS21155	COG1595	DNA-templated transcription, initiation
EP757_RS21170	COG0840	transmembrane signaling receptor activity
EP757_RS21195	COG0477	Major facilitator Superfamily
EP757_RS21220	COG0697	spore germination
EP757_RS21250	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
EP757_RS21260	COG1070	Carbohydrate kinase
EP757_RS21265	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EP757_RS21310	COG3304	Inner membrane component domain
EP757_RS21320	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EP757_RS21330	COG3033	Beta-eliminating lyase
EP757_RS21385	COG2814	Major facilitator Superfamily
EP757_RS21395	COG2890	protein-(glutamine-N5) methyltransferase activity
EP757_RS21420	COG2235	arginine
EP757_RS21430	COG3537	Alpha-1,2-mannosidase
EP757_RS21445	COG4948	Mandelate Racemase Muconate Lactonizing
EP757_RS21460	COG3842	ATPase activity
EP757_RS21470	COG1609	Transcriptional regulator
EP757_RS21495	COG0714	Associated with various cellular activities
EP757_RS21500	COG3552	Protein containing von Willebrand factor type A (VWA) domain
EP757_RS21520	COG1960	acyl-CoA dehydrogenase activity
EP757_RS21530	COG1802	Transcriptional regulator
EP757_RS21565	COG0243	molybdopterin cofactor binding
EP757_RS21580	COG1136	(ABC) transporter
EP757_RS21580	COG0577	efflux transmembrane transporter activity
EP757_RS21585	COG1136	(ABC) transporter
EP757_RS21600	COG0667	Aldo Keto reductase
EP757_RS21610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP757_RS21615	COG1309	transcriptional regulator
EP757_RS21620	COG0488	(ABC) transporter
EP757_RS21645	COG0697	spore germination
EP757_RS21650	COG2357	RelA SpoT domain protein
EP757_RS21665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS21675	COG2807	transmembrane transport
EP757_RS21750	COG1554	hydrolase, family 65, central catalytic
EP757_RS21805	COG0395	ABC-type sugar transport system, permease component
EP757_RS21810	COG1175	transmembrane transport
EP757_RS21815	COG1653	transport
EP757_RS21820	COG4821	SIS domain
EP757_RS21825	COG1737	Transcriptional regulator
EP757_RS21855	COG3903	Transcriptional regulator
EP757_RS21855	COG3629	intracellular signal transduction
EP757_RS21885	COG0583	DNA-binding transcription factor activity
EP757_RS21960	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS21975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EP757_RS21980	COG2409	Drug exporters of the RND superfamily
EP757_RS21990	COG3940	Belongs to the glycosyl hydrolase 43 family
EP757_RS22030	COG0439	Biotin carboxylase
EP757_RS22045	COG1253	flavin adenine dinucleotide binding
EP757_RS22065	COG3876	Protein conserved in bacteria
EP757_RS22070	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
EP757_RS22100	COG0583	DNA-binding transcription factor activity
EP757_RS22125	COG2197	response regulator
EP757_RS22130	COG4585	Histidine kinase
EP757_RS22170	COG1309	transcriptional regulator
EP757_RS22235	COG2197	response regulator
EP757_RS22240	COG4585	Histidine kinase
EP757_RS22245	COG2409	Drug exporters of the RND superfamily
EP757_RS22265	COG1595	DNA-templated transcription, initiation
EP757_RS22295	COG2409	Drug exporters of the RND superfamily
EP757_RS22325	COG1902	pentaerythritol trinitrate reductase activity
EP757_RS22380	COG4974	Belongs to the 'phage' integrase family
EP757_RS22405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EP757_RS22405	COG0574	Belongs to the PEP-utilizing enzyme family
EP757_RS22485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EP757_RS22515	COG0745	RESPONSE REGULATOR receiver
EP757_RS22520	COG5002	protein histidine kinase activity
EP757_RS22530	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
EP757_RS22535	COG1278	Cold shock
EP757_RS22560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP757_RS22585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EP757_RS22590	COG3290	protein histidine kinase activity
EP757_RS22600	COG0475	glutathione-regulated potassium exporter activity
EP757_RS22650	COG3629	intracellular signal transduction
EP757_RS22650	COG3903	Transcriptional regulator
EP757_RS22655	COG0165	Argininosuccinate lyase
EP757_RS22685	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EP757_RS22715	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EP757_RS22765	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS22790	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS22800	COG0492	ferredoxin-NADP+ reductase activity
EP757_RS22810	COG3384	dioxygenase
EP757_RS22830	COG0604	alcohol dehydrogenase
EP757_RS22850	COG5297	Belongs to the glycosyl hydrolase family 6
EP757_RS22850	COG4733	cellulase activity
EP757_RS22855	COG3693	PFAM glycoside hydrolase, family 10
EP757_RS22885	COG2814	Major facilitator Superfamily
EP757_RS22890	COG1940	carbohydrate kinase activity
EP757_RS22910	COG0318	PFAM AMP-dependent synthetase and ligase
EP757_RS22915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EP757_RS22920	COG1024	Enoyl-CoA hydratase
EP757_RS22925	COG1414	Transcriptional regulator
EP757_RS22935	COG3971	2-oxopent-4-enoate hydratase activity
EP757_RS22940	COG4569	acetaldehyde dehydrogenase (acetylating) activity
EP757_RS23000	COG1131	(ABC) transporter
EP757_RS23005	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EP757_RS23025	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EP757_RS23030	COG4585	Histidine kinase
EP757_RS23035	COG2197	response regulator
EP757_RS23040	COG1136	(ABC) transporter
EP757_RS23040	COG0577	efflux transmembrane transporter activity
EP757_RS23045	COG0577	efflux transmembrane transporter activity
EP757_RS23055	COG1131	(ABC) transporter
EP757_RS23070	COG2197	response regulator
EP757_RS23080	COG3903	Transcriptional regulator
EP757_RS23080	COG3629	intracellular signal transduction
EP757_RS23105	COG2197	response regulator
EP757_RS23115	COG1131	(ABC) transporter
EP757_RS23135	COG1982	Orn Lys Arg decarboxylase major
EP757_RS23140	COG1733	regulation of RNA biosynthetic process
EP757_RS23150	COG4221	oxidoreductase activity
EP757_RS23165	COG4585	Histidine kinase
EP757_RS23170	COG2197	response regulator
EP757_RS23180	COG1472	Belongs to the glycosyl hydrolase 3 family
EP757_RS23185	COG1609	Transcriptional regulator
EP757_RS23200	COG0395	ABC-type sugar transport system, permease component
EP757_RS23205	COG3250	beta-galactosidase activity
EP757_RS23210	COG1609	Transcriptional regulator
EP757_RS23240	COG2366	antibiotic biosynthetic process
EP757_RS23245	COG0702	epimerase
EP757_RS23250	COG1733	regulation of RNA biosynthetic process
EP757_RS23280	COG0477	Major facilitator Superfamily
EP757_RS23290	COG1653	transport
EP757_RS23335	COG3328	transposase activity
EP757_RS23370	COG1012	belongs to the aldehyde dehydrogenase family
EP757_RS23390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EP757_RS23400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EP757_RS23405	COG3237	CsbD-like
EP757_RS23415	COG3328	transposase activity
EP757_RS23450	COG0667	Aldo Keto reductase
EP757_RS23480	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EP757_RS23560	COG0438	transferase activity, transferring glycosyl groups
EP757_RS23585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EP757_RS23585	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EP757_RS23600	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EP757_RS23605	COG0673	inositol 2-dehydrogenase activity
EP757_RS23650	COG0589	response to stress
EP757_RS23655	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EP757_RS23665	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EP757_RS23715	COG1609	Transcriptional regulator
EP757_RS23725	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EP757_RS23745	COG3629	intracellular signal transduction
EP757_RS23745	COG3903	Transcriptional regulator
EP757_RS23760	COG0644	oxidoreductase
EP757_RS23780	COG1012	belongs to the aldehyde dehydrogenase family
EP757_RS23805	COG0494	nUDIX hydrolase
EP757_RS23870	COG1131	(ABC) transporter
EP757_RS23885	COG1316	TRANSCRIPTIONal
EP757_RS23890	COG0840	transmembrane signaling receptor activity
EP757_RS23910	COG0569	domain protein
EP757_RS23920	COG2130	NADP-dependent
EP757_RS23945	COG0235	Class ii aldolase
EP757_RS23955	COG1609	Transcriptional regulator
EP757_RS23960	COG1879	ABC-type sugar transport system periplasmic component
EP757_RS23970	COG1172	Belongs to the binding-protein-dependent transport system permease family
EP757_RS23975	COG1172	Belongs to the binding-protein-dependent transport system permease family
EP757_RS23980	COG2160	L-arabinose isomerase activity
EP757_RS24000	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EP757_RS24030	COG2409	Drug exporters of the RND superfamily
EP757_RS24055	COG0640	Transcriptional regulator
EP757_RS24080	COG0395	ABC-type sugar transport system, permease component
EP757_RS24115	COG1017	nitric oxide dioxygenase activity
EP757_RS24115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EP757_RS24130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EP757_RS24140	COG1116	anion transmembrane transporter activity
EP757_RS24160	COG0477	Major facilitator Superfamily
EP757_RS24190	COG1486	melibiose metabolic process
EP757_RS24220	COG4585	Histidine kinase
EP757_RS24225	COG2197	response regulator
EP757_RS24230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EP757_RS24235	COG2011	ABC-type metal ion transport system permease component
EP757_RS24240	COG1464	Belongs to the NlpA lipoprotein family
EP757_RS24255	COG0686	Belongs to the AlaDH PNT family
EP757_RS24290	COG2226	methyltransferase
EP757_RS24315	COG1902	pentaerythritol trinitrate reductase activity
EP757_RS24320	COG2814	Major facilitator Superfamily
EP757_RS24325	COG1609	Transcriptional regulator
EP757_RS24335	COG1122	ATPase activity
EP757_RS24345	COG4721	ABC-type cobalt transport system, permease component
EP757_RS24355	COG0542	response to heat
EP757_RS24370	COG3629	intracellular signal transduction
EP757_RS24370	COG3903	Transcriptional regulator
EP757_RS24375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP757_RS24410	COG0179	Fumarylacetoacetate (FAA) hydrolase
EP757_RS24425	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EP757_RS24430	COG1309	transcriptional regulator
EP757_RS24505	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EP757_RS24510	COG0028	Belongs to the TPP enzyme family
EP757_RS24515	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EP757_RS24535	COG3360	Dodecin
EP757_RS24540	COG2203	Gaf domain
EP757_RS24540	COG3706	GGDEF domain
EP757_RS24540	COG5001	Diguanylate cyclase
EP757_RS24540	COG4251	negative regulation of phosphorylation
EP757_RS24610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EP757_RS24620	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EP757_RS24640	COG0596	Alpha beta hydrolase
EP757_RS24655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EP757_RS24660	COG1024	Enoyl-CoA hydratase
EP757_RS24670	COG1595	DNA-templated transcription, initiation
EP757_RS24695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EP757_RS24700	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EP757_RS24705	COG1120	ATPase activity
EP757_RS24710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EP757_RS24715	COG2199	diguanylate cyclase activity
EP757_RS24715	COG3287	FIST C domain
EP757_RS24715	COG2200	EAL domain
EP757_RS24785	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EP757_RS24820	COG2197	response regulator
EP757_RS24830	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EP757_RS24835	COG1595	DNA-templated transcription, initiation
EP757_RS24995	COG0596	Alpha beta hydrolase
EP757_RS25015	COG1414	Transcriptional regulator
EP757_RS25025	COG2124	cytochrome p450
EP757_RS25035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP757_RS25050	COG1609	Transcriptional regulator
EP757_RS25070	COG3250	beta-galactosidase activity
EP757_RS25075	COG1609	Transcriptional regulator
EP757_RS25100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EP757_RS25105	COG0778	Nitroreductase
EP757_RS25260	COG1902	pentaerythritol trinitrate reductase activity
EP757_RS25265	COG3480	Lon protease (S16) C-terminal proteolytic domain
EP757_RS25290	COG0515	serine threonine protein kinase
EP757_RS25290	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP757_RS25315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EP757_RS25320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EP757_RS25335	COG0765	amino acid transport
EP757_RS25370	COG1595	DNA-templated transcription, initiation
EP757_RS25415	COG3345	alpha-galactosidase
EP757_RS25420	COG3507	Belongs to the glycosyl hydrolase 43 family
EP757_RS25430	COG3693	PFAM glycoside hydrolase, family 10
EP757_RS25470	COG0702	epimerase
EP757_RS25505	COG1309	transcriptional regulator
EP757_RS25520	COG2197	response regulator
EP757_RS25530	COG4608	Belongs to the ABC transporter superfamily
EP757_RS25540	COG0444	Belongs to the ABC transporter superfamily
EP757_RS25545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EP757_RS25550	COG0601	transmembrane transport
EP757_RS25555	COG0747	negative chemotaxis
EP757_RS25585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EP757_RS25590	COG1653	transport
EP757_RS25595	COG1175	transmembrane transport
EP757_RS25600	COG0395	ABC-type sugar transport system, permease component
EP757_RS25630	COG3046	protein related to deoxyribodipyrimidine photolyase
EP757_RS25645	COG0395	ABC-type sugar transport system, permease component
EP757_RS25650	COG1175	transmembrane transport
EP757_RS25655	COG1653	transport
EP757_RS25675	COG2814	Major facilitator Superfamily
EP757_RS25705	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS25710	COG1960	acyl-CoA dehydrogenase activity
EP757_RS25755	COG1653	transport
EP757_RS25760	COG1175	transmembrane transport
EP757_RS25765	COG0395	ABC-type sugar transport system, permease component
EP757_RS25775	COG3842	ATPase activity
EP757_RS25780	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EP757_RS25870	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS25895	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EP757_RS25905	COG0183	Belongs to the thiolase family
EP757_RS25920	COG0318	PFAM AMP-dependent synthetase and ligase
EP757_RS25925	COG1960	acyl-CoA dehydrogenase activity
EP757_RS25930	COG1960	acyl-CoA dehydrogenase activity
EP757_RS25935	COG1012	belongs to the aldehyde dehydrogenase family
EP757_RS25950	COG0477	Major facilitator Superfamily
EP757_RS25965	COG1271	oxidase subunit
EP757_RS25970	COG1252	NADH dehydrogenase
EP757_RS25980	COG0494	nUDIX hydrolase
EP757_RS25990	COG2340	Cysteine-rich secretory protein family
EP757_RS25995	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS26005	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EP757_RS26010	COG0243	molybdopterin cofactor binding
EP757_RS26025	COG0142	geranyltranstransferase activity
EP757_RS26045	COG1131	(ABC) transporter
EP757_RS26050	COG4585	Histidine kinase
EP757_RS26055	COG2197	response regulator
EP757_RS26075	COG1733	regulation of RNA biosynthetic process
EP757_RS26100	COG0745	RESPONSE REGULATOR receiver
EP757_RS26105	COG2205	protein histidine kinase activity
EP757_RS26115	COG1228	amidohydrolase
EP757_RS26120	COG1278	Cold shock
EP757_RS26140	COG4941	Belongs to the sigma-70 factor family
EP757_RS26155	COG1672	PFAM Archaeal ATPase
EP757_RS26155	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EP757_RS26170	COG0179	Fumarylacetoacetate (FAA) hydrolase
EP757_RS26175	COG0179	Fumarylacetoacetate (FAA) hydrolase
EP757_RS26185	COG1414	Transcriptional regulator
EP757_RS26190	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS26195	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS26200	COG2211	Major facilitator Superfamily
EP757_RS26205	COG1228	amidohydrolase
EP757_RS26250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS26290	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EP757_RS26300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EP757_RS26320	COG0583	DNA-binding transcription factor activity
EP757_RS26365	COG1595	DNA-templated transcription, initiation
EP757_RS26385	COG0640	Transcriptional regulator
EP757_RS26430	COG0583	DNA-binding transcription factor activity
EP757_RS26470	COG1132	(ABC) transporter
EP757_RS26485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EP757_RS26490	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EP757_RS26495	COG1120	ATPase activity
EP757_RS26525	COG0596	Alpha beta hydrolase
EP757_RS26560	COG4585	Histidine kinase
EP757_RS26570	COG0697	spore germination
EP757_RS26575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EP757_RS26580	COG1595	DNA-templated transcription, initiation
EP757_RS26620	COG1619	proteins homologs of microcin C7 resistance protein MccF
EP757_RS26625	COG0039	L-malate dehydrogenase activity
EP757_RS26655	COG3291	Pkd domain containing protein
EP757_RS26675	COG0840	transmembrane signaling receptor activity
EP757_RS26680	COG0508	dehydrogenase complex catalyzes the overall conversion of
EP757_RS26695	COG1522	sequence-specific DNA binding
EP757_RS26705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EP757_RS26760	COG3559	Exporter of polyketide antibiotics
EP757_RS26785	COG0494	nUDIX hydrolase
EP757_RS26805	COG2814	Major facilitator Superfamily
EP757_RS26815	COG1595	DNA-templated transcription, initiation
EP757_RS26850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EP757_RS26860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EP757_RS26865	COG5001	Diguanylate cyclase
EP757_RS26865	COG3300	MHYT domain
EP757_RS26870	COG3537	Alpha-1,2-mannosidase
EP757_RS26900	COG2365	Tyrosine phosphatase family
EP757_RS26905	COG0515	serine threonine protein kinase
EP757_RS26905	COG2815	serine threonine protein kinase
EP757_RS26995	COG0765	amino acid transport
EP757_RS27000	COG1126	abc transporter atp-binding protein
EP757_RS27025	COG0154	amidase activity
EP757_RS27040	COG2186	Transcriptional regulator
EP757_RS27045	COG1609	Transcriptional regulator
EP757_RS27085	COG0667	Aldo Keto reductase
EP757_RS27095	COG0346	lactoylglutathione lyase activity
EP757_RS27110	COG0477	Major facilitator Superfamily
EP757_RS27115	COG3226	Transcriptional regulator
EP757_RS27125	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS27125	COG3347	Dehydrogenase
EP757_RS27130	COG1070	Carbohydrate kinase
EP757_RS27135	COG0247	lactate metabolic process
EP757_RS27140	COG1139	Iron-sulfur cluster binding protein
EP757_RS27145	COG1556	Lactate utilization protein
EP757_RS27170	COG0745	RESPONSE REGULATOR receiver
EP757_RS27195	COG1136	(ABC) transporter
EP757_RS27195	COG0577	efflux transmembrane transporter activity
EP757_RS27200	COG0577	efflux transmembrane transporter activity
EP757_RS27200	COG1136	(ABC) transporter
EP757_RS27215	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EP757_RS27230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EP757_RS27245	COG4948	Mandelate Racemase Muconate Lactonizing
EP757_RS27265	COG1191	sigma factor activity
EP757_RS27315	COG0531	amino acid
EP757_RS27360	COG1116	anion transmembrane transporter activity
EP757_RS27365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EP757_RS27370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EP757_RS27380	COG1414	Transcriptional regulator
EP757_RS27385	COG5001	Diguanylate cyclase
EP757_RS27385	COG3300	MHYT domain
EP757_RS27445	COG4176	ABC-type proline glycine betaine transport system permease component
EP757_RS27450	COG0517	IMP dehydrogenase activity
EP757_RS27450	COG4175	Glycine betaine
EP757_RS27455	COG1012	belongs to the aldehyde dehydrogenase family
EP757_RS27465	COG2146	nitrite reductase [NAD(P)H] activity
EP757_RS27485	COG4638	Rieske (2fe-2S)
EP757_RS27565	COG1414	Transcriptional regulator
EP757_RS27570	COG3485	protocatechuate 3,4-dioxygenase
EP757_RS27575	COG3485	protocatechuate 3,4-dioxygenase
EP757_RS27585	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EP757_RS27620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP757_RS27630	COG0179	Fumarylacetoacetate (FAA) hydrolase
EP757_RS27645	COG2409	Drug exporters of the RND superfamily
EP757_RS27730	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EP757_RS27745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EP757_RS27835	COG1396	sequence-specific DNA binding
EP757_RS27860	COG1960	acyl-CoA dehydrogenase activity
EP757_RS27870	COG1960	acyl-CoA dehydrogenase activity
EP757_RS27895	COG0446	pyridine nucleotide-disulphide oxidoreductase
EP757_RS27900	COG1472	Belongs to the glycosyl hydrolase 3 family
EP757_RS27905	COG1609	Transcriptional regulator
EP757_RS27920	COG0395	ABC-type sugar transport system, permease component
EP757_RS27925	COG1501	Belongs to the glycosyl hydrolase 31 family
EP757_RS27955	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EP757_RS27960	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
EP757_RS27975	COG1122	ATPase activity
EP757_RS27990	COG0310	cobalt ion transport
EP757_RS28025	COG5002	protein histidine kinase activity
EP757_RS28030	COG2204	response regulator
EP757_RS28040	COG4952	isomerase
EP757_RS28045	COG1172	Belongs to the binding-protein-dependent transport system permease family
EP757_RS28050	COG1172	Belongs to the binding-protein-dependent transport system permease family
EP757_RS28055	COG1129	ABC transporter
EP757_RS28060	COG1879	ABC-type sugar transport system periplasmic component
EP757_RS28080	COG0515	serine threonine protein kinase
EP757_RS28080	COG2815	serine threonine protein kinase
EP757_RS28090	COG0436	Aminotransferase
EP757_RS28100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EP757_RS28105	COG1012	belongs to the aldehyde dehydrogenase family
EP757_RS28110	COG3842	ATPase activity
EP757_RS28120	COG1176	ABC-type spermidine putrescine transport system, permease component I
EP757_RS28125	COG1177	transmembrane transport
EP757_RS28130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EP757_RS28145	COG5002	protein histidine kinase activity
EP757_RS28145	COG2198	Histidine kinase
EP757_RS28145	COG0784	Response regulator, receiver
EP757_RS28150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EP757_RS28155	COG1522	sequence-specific DNA binding
EP757_RS28160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EP757_RS28165	COG1012	belongs to the aldehyde dehydrogenase family
EP757_RS28170	COG2208	phosphoserine phosphatase activity
EP757_RS28175	COG1472	Belongs to the glycosyl hydrolase 3 family
EP757_RS28185	COG1175	transmembrane transport
EP757_RS28205	COG0248	Ppx GppA phosphatase
EP757_RS28210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EP757_RS28235	COG3191	aminopeptidase activity
EP757_RS28250	COG0442	prolyl-tRNA aminoacylation
EP757_RS28255	COG0702	epimerase
EP757_RS28260	COG1733	regulation of RNA biosynthetic process
EP757_RS28270	COG0840	transmembrane signaling receptor activity
EP757_RS28275	COG5001	Diguanylate cyclase
EP757_RS28280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EP757_RS28300	COG0747	negative chemotaxis
EP757_RS28310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EP757_RS28320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS28325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS28330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS28335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS28355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP757_RS28365	COG0765	amino acid transport
EP757_RS28370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EP757_RS28375	COG4521	taurine ABC transporter
EP757_RS28380	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EP757_RS28400	COG0366	Alpha amylase catalytic
EP757_RS28405	COG1609	Transcriptional regulator
EP757_RS28415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS28420	COG2409	Drug exporters of the RND superfamily
EP757_RS28430	COG1132	(ABC) transporter
EP757_RS28450	COG0778	Nitroreductase
EP757_RS28460	COG0372	Belongs to the citrate synthase family
EP757_RS28475	COG0508	dehydrogenase complex catalyzes the overall conversion of
EP757_RS28475	COG0596	Alpha beta hydrolase
EP757_RS28520	COG0243	molybdopterin cofactor binding
EP757_RS28525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EP757_RS28535	COG2223	nitrite transmembrane transporter activity
EP757_RS28565	COG0105	UTP biosynthetic process
EP757_RS28570	COG1609	Transcriptional regulator
EP757_RS28575	COG2223	nitrite transmembrane transporter activity
EP757_RS28595	COG0577	efflux transmembrane transporter activity
EP757_RS28595	COG1136	(ABC) transporter
EP757_RS28600	COG0577	efflux transmembrane transporter activity
EP757_RS28600	COG1136	(ABC) transporter
EP757_RS28610	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS28620	COG0300	oxidoreductase activity
EP757_RS28655	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS28695	COG4191	Histidine kinase
EP757_RS28705	COG1448	Aminotransferase
EP757_RS28735	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EP757_RS28740	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EP757_RS28745	COG2080	2 iron, 2 sulfur cluster binding
EP757_RS28785	COG0601	transmembrane transport
EP757_RS28790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EP757_RS28850	COG0583	DNA-binding transcription factor activity
EP757_RS28870	COG1228	amidohydrolase
EP757_RS28890	COG4952	isomerase
EP757_RS28925	COG0706	membrane insertase activity
EP757_RS28930	COG2814	Major facilitator Superfamily
EP757_RS28950	COG0670	Belongs to the BI1 family
EP757_RS28955	COG2267	carboxylic ester hydrolase activity
EP757_RS28965	COG1435	thymidine kinase activity
EP757_RS28985	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS29015	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EP757_RS29020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EP757_RS29030	COG1335	isochorismatase
EP757_RS29040	COG0840	transmembrane signaling receptor activity
EP757_RS29060	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EP757_RS29065	COG0583	DNA-binding transcription factor activity
EP757_RS29070	COG2814	Major facilitator Superfamily
EP757_RS29080	COG4941	Belongs to the sigma-70 factor family
EP757_RS29095	COG0604	alcohol dehydrogenase
EP757_RS29105	COG5001	Diguanylate cyclase
EP757_RS29120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS29160	COG1024	Enoyl-CoA hydratase
EP757_RS29170	COG0738	Major facilitator superfamily
EP757_RS29195	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EP757_RS29200	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EP757_RS29210	COG0667	Aldo Keto reductase
EP757_RS29220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS29230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EP757_RS29250	COG0574	Belongs to the PEP-utilizing enzyme family
EP757_RS29250	COG3848	Pyruvate phosphate dikinase
EP757_RS29255	COG1309	transcriptional regulator
EP757_RS29275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EP757_RS29280	COG3708	Transcriptional regulator
EP757_RS29280	COG2207	Transcriptional regulator
EP757_RS29285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EP757_RS29295	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EP757_RS29315	COG2197	response regulator
EP757_RS29330	COG3507	Belongs to the glycosyl hydrolase 43 family
EP757_RS29340	COG0542	response to heat
EP757_RS29370	COG4251	negative regulation of phosphorylation
EP757_RS29375	COG0745	RESPONSE REGULATOR receiver
EP757_RS29380	COG2770	Histidine kinase
EP757_RS29380	COG2208	phosphoserine phosphatase activity
EP757_RS29400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EP757_RS29415	COG1051	belongs to the nudix hydrolase family
EP757_RS29455	COG1063	alcohol dehydrogenase
EP757_RS29475	COG3940	Belongs to the glycosyl hydrolase 43 family
EP757_RS29495	COG0596	Alpha beta hydrolase
EP757_RS29540	COG1404	Belongs to the peptidase S8 family
EP757_RS29545	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EP757_RS29555	COG0483	inositol monophosphate 1-phosphatase activity
EP757_RS29560	COG4122	O-methyltransferase activity
EP757_RS29565	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EP757_RS29565	COG0463	Glycosyl transferase, family 2
EP757_RS29580	COG0667	Aldo Keto reductase
EP757_RS29595	COG2197	response regulator
EP757_RS29605	COG1396	sequence-specific DNA binding
EP757_RS29610	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EP757_RS29630	COG2226	methyltransferase
EP757_RS29665	COG1846	Transcriptional regulator
EP757_RS29705	COG0657	acetylesterase activity
EP757_RS29750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EP757_RS29755	COG0402	S-adenosylhomocysteine deaminase activity
EP757_RS29760	COG1414	Transcriptional regulator
EP757_RS29775	COG1408	metallophosphoesterase
EP757_RS29780	COG3321	synthase
EP757_RS29780	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS29780	COG0604	alcohol dehydrogenase
EP757_RS29835	COG5002	protein histidine kinase activity
EP757_RS29850	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EP757_RS29875	COG5002	protein histidine kinase activity
EP757_RS29885	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EP757_RS29895	COG0803	Belongs to the bacterial solute-binding protein 9 family
EP757_RS29900	COG1121	(ABC) transporter
EP757_RS29905	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EP757_RS29915	COG0640	Transcriptional regulator
EP757_RS29920	COG2072	flavoprotein involved in K transport
EP757_RS29940	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EP757_RS29945	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EP757_RS29955	COG4941	Belongs to the sigma-70 factor family
EP757_RS29960	COG3795	YCII-related domain
EP757_RS29970	COG1064	alcohol dehydrogenase
EP757_RS29980	COG3507	Belongs to the glycosyl hydrolase 43 family
EP757_RS29985	COG2197	response regulator
EP757_RS29990	COG4585	Histidine kinase
EP757_RS30075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EP757_RS30080	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS30095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS30105	COG1832	CoA-binding protein
EP757_RS30115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EP757_RS30125	COG2072	flavoprotein involved in K transport
EP757_RS30130	COG2205	protein histidine kinase activity
EP757_RS30135	COG0745	RESPONSE REGULATOR receiver
EP757_RS30145	COG2072	flavoprotein involved in K transport
EP757_RS30150	COG1733	regulation of RNA biosynthetic process
EP757_RS30245	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EP757_RS30275	COG1222	aaa ATPase
EP757_RS30400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EP757_RS30405	COG0438	transferase activity, transferring glycosyl groups
EP757_RS30410	COG2267	carboxylic ester hydrolase activity
EP757_RS30445	COG0477	Major facilitator Superfamily
EP757_RS30475	COG5002	protein histidine kinase activity
EP757_RS30475	COG5001	Diguanylate cyclase
EP757_RS30475	COG3447	MASE1 domain protein
EP757_RS30485	COG2268	Band 7 protein
EP757_RS30500	COG1846	Transcriptional regulator
EP757_RS30505	COG2814	Major facilitator Superfamily
EP757_RS30535	COG0110	maltose O-acetyltransferase activity
EP757_RS30600	COG5001	Diguanylate cyclase
EP757_RS30630	COG2197	response regulator
EP757_RS30635	COG4585	Histidine kinase
EP757_RS30640	COG3940	Belongs to the glycosyl hydrolase 43 family
EP757_RS30650	COG0300	oxidoreductase activity
EP757_RS30665	COG1136	(ABC) transporter
EP757_RS30665	COG0577	efflux transmembrane transporter activity
EP757_RS30680	COG1476	TRANSCRIPTIONal
EP757_RS30685	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS30685	COG3321	synthase
EP757_RS30685	COG0604	alcohol dehydrogenase
EP757_RS30690	COG1960	acyl-CoA dehydrogenase activity
EP757_RS30705	COG3300	MHYT domain
EP757_RS30705	COG5001	Diguanylate cyclase
EP757_RS30725	COG0745	RESPONSE REGULATOR receiver
EP757_RS30730	COG2205	protein histidine kinase activity
EP757_RS30740	COG2197	response regulator
EP757_RS30750	COG1940	carbohydrate kinase activity
EP757_RS30755	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EP757_RS30785	COG1940	carbohydrate kinase activity
EP757_RS30810	COG0596	Alpha beta hydrolase
EP757_RS30835	COG0784	Response regulator, receiver
EP757_RS30855	COG0714	Associated with various cellular activities
EP757_RS30865	COG0596	Alpha beta hydrolase
EP757_RS30875	COG0531	amino acid
EP757_RS30890	COG0640	Transcriptional regulator
EP757_RS30905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EP757_RS30915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EP757_RS30925	COG0204	Acyl-transferase
EP757_RS30945	COG2197	response regulator
EP757_RS30950	COG0563	adenylate kinase activity
EP757_RS30955	COG0254	rRNA binding
EP757_RS30965	COG2124	cytochrome p450
EP757_RS30980	COG1131	(ABC) transporter
EP757_RS30985	COG4585	Histidine kinase
EP757_RS30990	COG2197	response regulator
EP757_RS30995	COG5297	Belongs to the glycosyl hydrolase family 6
EP757_RS31005	COG0583	DNA-binding transcription factor activity
EP757_RS31070	COG5002	protein histidine kinase activity
EP757_RS31085	COG1595	DNA-templated transcription, initiation
EP757_RS31120	COG1132	(ABC) transporter
EP757_RS31125	COG1132	(ABC) transporter
EP757_RS31150	COG1960	acyl-CoA dehydrogenase activity
EP757_RS31170	COG0277	FAD linked oxidase domain protein
EP757_RS31205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS31225	COG0583	DNA-binding transcription factor activity
EP757_RS31230	COG5006	permease, DMT superfamily
EP757_RS31270	COG0789	Transcriptional regulator
EP757_RS31275	COG4974	Belongs to the 'phage' integrase family
EP757_RS31295	COG0443	Heat shock 70 kDa protein
EP757_RS31300	COG2354	Protein conserved in bacteria
EP757_RS31325	COG0583	DNA-binding transcription factor activity
EP757_RS31330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EP757_RS31335	COG2188	Transcriptional regulator
EP757_RS31375	COG1131	(ABC) transporter
EP757_RS31380	COG0842	Transport permease protein
EP757_RS31385	COG4585	Histidine kinase
EP757_RS31390	COG2197	response regulator
EP757_RS31395	COG1191	sigma factor activity
EP757_RS31400	COG0488	(ABC) transporter
EP757_RS31405	COG1968	undecaprenyl-diphosphatase activity
EP757_RS31440	COG2270	Major facilitator Superfamily
EP757_RS31460	COG2255	four-way junction helicase activity
EP757_RS31480	COG0456	acetyltransferase
EP757_RS31480	COG1846	Transcriptional regulator
EP757_RS31500	COG2814	Major facilitator Superfamily
EP757_RS31535	COG1846	Transcriptional regulator
EP757_RS31560	COG1764	response to oxidative stress
EP757_RS31565	COG1846	Transcriptional regulator
EP757_RS31585	COG4702	Belongs to the UPF0303 family
EP757_RS31610	COG1309	transcriptional regulator
EP757_RS31635	COG0019	diaminopimelate decarboxylase activity
EP757_RS31655	COG0488	(ABC) transporter
EP757_RS31665	COG0667	Aldo Keto reductase
EP757_RS31685	COG0242	peptide deformylase activity
EP757_RS31695	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EP757_RS31705	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EP757_RS31705	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EP757_RS31710	COG0667	Aldo Keto reductase
EP757_RS31740	COG5001	Diguanylate cyclase
EP757_RS31750	COG1960	acyl-CoA dehydrogenase activity
EP757_RS31760	COG1024	Enoyl-CoA hydratase
EP757_RS31765	COG0318	PFAM AMP-dependent synthetase and ligase
EP757_RS31770	COG3599	regulation of cell shape
EP757_RS31780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EP757_RS31805	COG0346	lactoylglutathione lyase activity
EP757_RS31810	COG0640	Transcriptional regulator
EP757_RS31845	COG0508	dehydrogenase complex catalyzes the overall conversion of
EP757_RS31845	COG0596	Alpha beta hydrolase
EP757_RS31865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EP757_RS31885	COG0840	transmembrane signaling receptor activity
EP757_RS31890	COG5002	protein histidine kinase activity
EP757_RS31910	COG1473	amidohydrolase
EP757_RS31925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP757_RS31960	COG1846	Transcriptional regulator
EP757_RS31970	COG0659	secondary active sulfate transmembrane transporter activity
EP757_RS31975	COG0789	Transcriptional regulator
EP757_RS31995	COG1902	pentaerythritol trinitrate reductase activity
EP757_RS32020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EP757_RS32025	COG1121	(ABC) transporter
EP757_RS32045	COG0697	spore germination
EP757_RS32050	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EP757_RS32065	COG2376	Dihydroxyacetone kinase
EP757_RS32075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP757_RS32100	COG1695	Transcriptional regulator
EP757_RS32115	COG3485	protocatechuate 3,4-dioxygenase
EP757_RS32120	COG1454	alcohol dehydrogenase
EP757_RS32125	COG0583	DNA-binding transcription factor activity
EP757_RS32130	COG0183	Belongs to the thiolase family
EP757_RS32140	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EP757_RS32190	COG1940	carbohydrate kinase activity
EP757_RS32210	COG0673	inositol 2-dehydrogenase activity
EP757_RS32220	COG2226	methyltransferase
EP757_RS32230	COG0667	Aldo Keto reductase
EP757_RS32235	COG0640	Transcriptional regulator
EP757_RS32255	COG0789	Transcriptional regulator
EP757_RS32295	COG2226	methyltransferase
EP757_RS32305	COG1309	transcriptional regulator
EP757_RS32315	COG0438	transferase activity, transferring glycosyl groups
EP757_RS32325	COG0142	geranyltranstransferase activity
EP757_RS32350	COG1082	Xylose isomerase domain protein TIM barrel
EP757_RS32355	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EP757_RS32395	COG1733	regulation of RNA biosynthetic process
EP757_RS32430	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EP757_RS32450	COG0300	oxidoreductase activity
EP757_RS32470	COG2197	response regulator
EP757_RS32485	COG2356	endonuclease I
EP757_RS32505	COG0778	Nitroreductase
EP757_RS32510	COG1720	tRNA m6t6A37 methyltransferase activity
EP757_RS32515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EP757_RS32530	COG1309	transcriptional regulator
EP757_RS32535	COG4221	oxidoreductase activity
EP757_RS32540	COG2197	response regulator
EP757_RS32545	COG0110	maltose O-acetyltransferase activity
EP757_RS32560	COG0672	)-iron permease
EP757_RS32570	COG2837	iron assimilation
EP757_RS32580	COG0494	nUDIX hydrolase
EP757_RS32605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EP757_RS32610	COG2197	response regulator
EP757_RS32615	COG4585	Histidine kinase
EP757_RS32640	COG0443	Heat shock 70 kDa protein
EP757_RS32655	COG0596	Alpha beta hydrolase
EP757_RS32675	COG0277	FAD linked oxidase domain protein
EP757_RS32675	COG0247	lactate metabolic process
EP757_RS32725	COG0596	Alpha beta hydrolase
EP757_RS32740	COG1595	DNA-templated transcription, initiation
EP757_RS32755	COG2226	methyltransferase
EP757_RS32770	COG2072	flavoprotein involved in K transport
EP757_RS32780	COG0446	pyridine nucleotide-disulphide oxidoreductase
EP757_RS32780	COG1902	pentaerythritol trinitrate reductase activity
EP757_RS32825	COG0765	amino acid transport
EP757_RS32830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP757_RS32835	COG0515	serine threonine protein kinase
EP757_RS32835	COG2815	serine threonine protein kinase
EP757_RS32845	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS32870	COG2070	2-Nitropropane dioxygenase
EP757_RS33005	COG0492	ferredoxin-NADP+ reductase activity
EP757_RS33025	COG2909	trisaccharide binding
EP757_RS33035	COG0277	FAD linked oxidase domain protein
EP757_RS33040	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS33050	COG1335	isochorismatase
EP757_RS33060	COG1024	Enoyl-CoA hydratase
EP757_RS33075	COG2200	EAL domain
EP757_RS33080	COG0640	Transcriptional regulator
EP757_RS33085	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS33110	COG1940	carbohydrate kinase activity
EP757_RS33115	COG2814	Major facilitator Superfamily
EP757_RS33120	COG5001	Diguanylate cyclase
EP757_RS33120	COG3300	MHYT domain
EP757_RS33135	COG0730	response to heat
EP757_RS33145	COG5006	permease, DMT superfamily
EP757_RS33150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EP757_RS33155	COG5001	Diguanylate cyclase
EP757_RS33155	COG3300	MHYT domain
EP757_RS33160	COG5001	Diguanylate cyclase
EP757_RS33160	COG3300	MHYT domain
EP757_RS33215	COG1742	UPF0060 membrane protein
EP757_RS33225	COG0300	oxidoreductase activity
EP757_RS33270	COG4585	Histidine kinase
EP757_RS33275	COG2197	response regulator
EP757_RS33320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP757_RS33345	COG0405	Gamma-glutamyltransferase
EP757_RS33355	COG3619	membrane
EP757_RS33375	COG1090	epimerase
EP757_RS33405	COG1404	Belongs to the peptidase S8 family
EP757_RS33410	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EP757_RS33410	COG1672	PFAM Archaeal ATPase
EP757_RS33490	COG3401	FG-GAP repeat protein
EP757_RS33505	COG1309	transcriptional regulator
EP757_RS33515	COG0783	Belongs to the Dps family
EP757_RS33520	COG1228	amidohydrolase
EP757_RS33540	COG1309	transcriptional regulator
EP757_RS33550	COG1760	l-serine dehydratase
EP757_RS33555	COG1597	lipid kinase activity
EP757_RS33560	COG0129	dihydroxy-acid dehydratase activity
EP757_RS33565	COG0583	DNA-binding transcription factor activity
EP757_RS33575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EP757_RS33590	COG1309	transcriptional regulator
EP757_RS33620	COG1073	alpha beta
EP757_RS33655	COG2814	Major facilitator Superfamily
EP757_RS33670	COG2409	Drug exporters of the RND superfamily
EP757_RS33685	COG0840	transmembrane signaling receptor activity
EP757_RS33695	COG0129	dihydroxy-acid dehydratase activity
EP757_RS33715	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EP757_RS33720	COG0840	transmembrane signaling receptor activity
EP757_RS33725	COG4941	Belongs to the sigma-70 factor family
EP757_RS33790	COG1131	(ABC) transporter
EP757_RS33830	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EP757_RS33865	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EP757_RS33940	COG1172	Belongs to the binding-protein-dependent transport system permease family
EP757_RS33945	COG1129	ABC transporter
EP757_RS34020	COG1063	alcohol dehydrogenase
EP757_RS34075	COG0529	Catalyzes the synthesis of activated sulfate
EP757_RS34150	COG4221	oxidoreductase activity
EP757_RS34160	COG0069	glutamate synthase activity
EP757_RS34170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EP757_RS34180	COG0670	Belongs to the BI1 family
EP757_RS34235	COG2272	Belongs to the type-B carboxylesterase lipase family
EP757_RS34245	COG3408	Glycogen debranching enzyme
EP757_RS34255	COG3250	beta-galactosidase activity
EP757_RS34260	COG0395	ABC-type sugar transport system, permease component
EP757_RS34265	COG1175	transmembrane transport
EP757_RS34270	COG1609	Transcriptional regulator
EP757_RS34275	COG1609	Transcriptional regulator
EP757_RS34285	COG2226	methyltransferase
EP757_RS34290	COG3135	benzoate transporter
EP757_RS34350	COG2423	ornithine cyclodeaminase activity
EP757_RS34375	COG4608	Belongs to the ABC transporter superfamily
EP757_RS34385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EP757_RS34390	COG0601	transmembrane transport
EP757_RS34420	COG0702	epimerase
EP757_RS34425	COG1733	regulation of RNA biosynthetic process
EP757_RS34460	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EP757_RS34465	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EP757_RS34470	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EP757_RS34490	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EP757_RS34500	COG0028	Belongs to the TPP enzyme family
EP757_RS34505	COG1012	belongs to the aldehyde dehydrogenase family
EP757_RS34510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EP757_RS34525	COG1082	Xylose isomerase domain protein TIM barrel
EP757_RS34525	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EP757_RS34535	COG0436	Aminotransferase
EP757_RS34560	COG0747	negative chemotaxis
EP757_RS34570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EP757_RS34580	COG4608	Belongs to the ABC transporter superfamily
EP757_RS34620	COG1309	transcriptional regulator
EP757_RS34650	COG1309	transcriptional regulator
EP757_RS34665	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EP757_RS34670	COG1737	Transcriptional regulator
EP757_RS34685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EP757_RS34690	COG0601	transmembrane transport
EP757_RS34705	COG1720	tRNA m6t6A37 methyltransferase activity
EP757_RS34725	COG3387	PFAM Glycoside hydrolase 15-related
EP757_RS34755	COG0697	spore germination
EP757_RS34760	COG0515	serine threonine protein kinase
EP757_RS34760	COG2815	serine threonine protein kinase
EP757_RS34780	COG0242	peptide deformylase activity
EP757_RS34815	COG2837	iron assimilation
EP757_RS34835	COG4935	Belongs to the peptidase S8 family
EP757_RS34835	COG1404	Belongs to the peptidase S8 family
EP757_RS34860	COG0640	Transcriptional regulator
EP757_RS34875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EP757_RS34880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP757_RS34895	COG0574	Belongs to the PEP-utilizing enzyme family
EP757_RS34895	COG3848	Pyruvate phosphate dikinase
EP757_RS34905	COG4941	Belongs to the sigma-70 factor family
EP757_RS34910	COG3795	YCII-related domain
EP757_RS34950	COG4585	Histidine kinase
EP757_RS34960	COG1131	(ABC) transporter
EP757_RS34990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP757_RS34995	COG0800	Aldolase
EP757_RS35000	COG0246	Mannitol dehydrogenase
EP757_RS35010	COG2721	sulfolactate sulfo-lyase activity
EP757_RS35030	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EP757_RS35035	COG1725	Transcriptional regulator
EP757_RS35095	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EP757_RS35100	COG0076	glutamate decarboxylase activity
EP757_RS35120	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
EP757_RS35125	COG1733	regulation of RNA biosynthetic process
EP757_RS35155	COG4978	Transcriptional regulator
EP757_RS35155	COG0789	Transcriptional regulator
EP757_RS35160	COG1760	l-serine dehydratase
EP757_RS35165	COG0509	glycine decarboxylation via glycine cleavage system
EP757_RS35170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EP757_RS35175	COG2205	protein histidine kinase activity
EP757_RS35275	COG0667	Aldo Keto reductase
EP757_RS35295	COG0463	Glycosyl transferase, family 2
EP757_RS35305	COG3973	AAA domain
EP757_RS35330	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EP757_RS35335	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EP757_RS35340	COG1228	amidohydrolase
EP757_RS35345	COG0604	alcohol dehydrogenase
EP757_RS35350	COG1509	lysine 2,3-aminomutase activity
EP757_RS35370	COG0583	DNA-binding transcription factor activity
EP757_RS35385	COG1960	acyl-CoA dehydrogenase activity
EP757_RS35390	COG2197	response regulator
EP757_RS35395	COG4585	Histidine kinase
EP757_RS35400	COG1136	(ABC) transporter
EP757_RS35410	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EP757_RS35415	COG1716	ATPase activity
EP757_RS35415	COG5001	Diguanylate cyclase
EP757_RS35435	COG3706	GGDEF domain
EP757_RS35455	COG2223	nitrite transmembrane transporter activity
EP757_RS35460	COG3447	MASE1 domain protein
EP757_RS35460	COG5001	Diguanylate cyclase
EP757_RS35460	COG5002	protein histidine kinase activity
EP757_RS35470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EP757_RS35530	COG1621	beta-fructofuranosidase activity
EP757_RS35545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP757_RS35550	COG2197	response regulator
EP757_RS35560	COG0667	Aldo Keto reductase
EP757_RS35565	COG0789	Transcriptional regulator
EP757_RS35620	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EP757_RS35630	COG5001	Diguanylate cyclase
EP757_RS35645	COG3022	response to hydroperoxide
EP757_RS35650	COG0545	Peptidyl-prolyl cis-trans isomerase
EP757_RS35685	COG4279	zinc finger
EP757_RS35690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EP757_RS35715	COG2124	cytochrome p450
EP757_RS35730	COG0531	amino acid
EP757_RS35740	COG0515	serine threonine protein kinase
EP757_RS35765	COG1072	(Pantothenic acid kinase))
EP757_RS35770	COG1408	metallophosphoesterase
EP757_RS35795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP757_RS35820	COG3328	transposase activity
EP757_RS35825	COG0596	Alpha beta hydrolase
EP757_RS35830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EP757_RS35835	COG2151	metal-sulfur cluster biosynthetic enzyme
EP757_RS35840	COG3396	Phenylacetate-CoA oxygenase
EP757_RS35845	COG3460	Phenylacetate-CoA oxygenase
EP757_RS35850	COG3396	Phenylacetate-CoA oxygenase
EP757_RS35870	COG0673	inositol 2-dehydrogenase activity
EP757_RS35905	COG3962	Belongs to the TPP enzyme family
EP757_RS35910	COG3718	enzyme involved in inositol metabolism
EP757_RS35930	COG3384	dioxygenase
EP757_RS35955	COG1136	(ABC) transporter
EP757_RS35955	COG0577	efflux transmembrane transporter activity
EP757_RS35960	COG1136	(ABC) transporter
EP757_RS35965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP757_RS35970	COG2205	protein histidine kinase activity
EP757_RS35975	COG0745	RESPONSE REGULATOR receiver
EP757_RS35995	COG2197	response regulator
EP757_RS36005	COG0406	alpha-ribazole phosphatase activity
EP757_RS36020	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EP757_RS36060	COG1309	transcriptional regulator
EP757_RS36095	COG0515	serine threonine protein kinase
EP757_RS36125	COG1132	(ABC) transporter
EP757_RS36130	COG1309	transcriptional regulator
EP757_RS36145	COG2382	esterase
EP757_RS36160	COG0166	Belongs to the GPI family
EP757_RS36185	COG1653	transport
EP757_RS36190	COG1175	transmembrane transport
EP757_RS36195	COG0395	ABC-type sugar transport system, permease component
EP757_RS36215	COG3507	Belongs to the glycosyl hydrolase 43 family
EP757_RS36245	COG2197	response regulator
EP757_RS36250	COG4585	Histidine kinase
EP757_RS36285	COG4214	carbohydrate transport
EP757_RS36295	COG4213	ABC transporter substrate-binding protein
EP757_RS36315	COG1620	l-lactate permease
EP757_RS36320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EP757_RS36320	COG2080	2 iron, 2 sulfur cluster binding
EP757_RS36330	COG1271	oxidase subunit
EP757_RS36335	COG1294	oxidase, subunit
EP757_RS36340	COG4988	ABC transporter
EP757_RS36345	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EP757_RS36350	COG5002	protein histidine kinase activity
EP757_RS36375	COG3706	GGDEF domain
EP757_RS36400	COG2197	response regulator
EP757_RS36430	COG2217	Heavy metal translocating P-type atpase
EP757_RS36440	COG2909	trisaccharide binding
EP757_RS36450	COG0071	Belongs to the small heat shock protein (HSP20) family
EP757_RS36505	COG1309	transcriptional regulator
EP757_RS36525	COG1366	Belongs to the anti-sigma-factor antagonist family
EP757_RS36530	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EP757_RS36535	COG1309	transcriptional regulator
EP757_RS36565	COG1846	Transcriptional regulator
EP757_RS36565	COG1940	carbohydrate kinase activity
EP757_RS36570	COG3345	alpha-galactosidase
EP757_RS36575	COG3458	cephalosporin-C deacetylase activity
EP757_RS36610	COG0395	ABC-type sugar transport system, permease component
EP757_RS36615	COG4209	transmembrane transport
EP757_RS36620	COG1846	Transcriptional regulator
EP757_RS36620	COG1940	carbohydrate kinase activity
EP757_RS36635	COG3631	Ketosteroid isomerase-related protein
EP757_RS36655	COG4948	Mandelate Racemase Muconate Lactonizing
EP757_RS36660	COG0179	Fumarylacetoacetate (FAA) hydrolase
EP757_RS36680	COG2186	Transcriptional regulator
EP757_RS36740	COG5002	protein histidine kinase activity
EP757_RS36750	COG1309	transcriptional regulator
EP757_RS36775	COG4221	oxidoreductase activity
EP757_RS36780	COG1309	transcriptional regulator
EP757_RS36785	COG0412	Dienelactone hydrolase
EP757_RS36850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EP757_RS36915	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS36960	COG0789	Transcriptional regulator
EP757_RS36965	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EP757_RS37045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EP757_RS37050	COG3629	intracellular signal transduction
EP757_RS37050	COG3903	Transcriptional regulator
EP757_RS37055	COG3384	dioxygenase
EP757_RS37060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EP757_RS37065	COG2235	arginine
EP757_RS37070	COG0549	Belongs to the carbamate kinase family
EP757_RS37080	COG2319	Wd-40 repeat
EP757_RS37085	COG0456	acetyltransferase
EP757_RS37120	COG3142	Participates in the control of copper homeostasis
EP757_RS37135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS37145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS37155	COG1120	ATPase activity
EP757_RS37170	COG2267	carboxylic ester hydrolase activity
EP757_RS37180	COG3119	arylsulfatase activity
EP757_RS37190	COG2226	methyltransferase
EP757_RS37205	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS37245	COG0840	transmembrane signaling receptor activity
EP757_RS37275	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EP757_RS37285	COG1376	ErfK ybiS ycfS ynhG family protein
EP757_RS37335	COG3629	intracellular signal transduction
EP757_RS37335	COG3903	Transcriptional regulator
EP757_RS37345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EP757_RS37350	COG3509	depolymerase
EP757_RS37360	COG1185	polyribonucleotide nucleotidyltransferase activity
EP757_RS37360	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EP757_RS37360	COG0539	negative regulation of cytoplasmic translation
EP757_RS37395	COG4221	oxidoreductase activity
EP757_RS37400	COG0583	DNA-binding transcription factor activity
EP757_RS37415	COG0745	RESPONSE REGULATOR receiver
EP757_RS37445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EP757_RS37455	COG0501	Belongs to the peptidase M48B family
EP757_RS37465	COG1271	oxidase subunit
EP757_RS37470	COG1294	oxidase, subunit
EP757_RS37475	COG4988	ABC transporter
EP757_RS37525	COG0859	PFAM glycosyl transferase family 9
EP757_RS37530	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS37545	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EP757_RS37550	COG0297	glycogen (starch) synthase activity
EP757_RS37560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EP757_RS37570	COG2192	nodulation
EP757_RS37585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS37615	COG0477	Major facilitator Superfamily
EP757_RS37660	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS37670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP757_RS37675	COG0326	Molecular chaperone. Has ATPase activity
EP757_RS37685	COG2233	PERMEase
EP757_RS37725	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EP757_RS37750	COG0297	glycogen (starch) synthase activity
EP757_RS37770	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EP757_RS37785	COG2353	YceI-like domain
EP757_RS37800	COG0574	Belongs to the PEP-utilizing enzyme family
EP757_RS37800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EP757_RS37835	COG0277	FAD linked oxidase domain protein
EP757_RS37840	COG0277	FAD linked oxidase domain protein
EP757_RS37845	COG0247	lactate metabolic process
EP757_RS37860	COG1414	Transcriptional regulator
EP757_RS37890	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EP757_RS37895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS37900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EP757_RS37905	COG4213	ABC transporter substrate-binding protein
EP757_RS37910	COG0395	ABC-type sugar transport system, permease component
EP757_RS37915	COG1175	transmembrane transport
EP757_RS37930	COG0366	Alpha amylase catalytic
EP757_RS37935	COG0494	nUDIX hydrolase
EP757_RS37940	COG0009	L-threonylcarbamoyladenylate synthase
EP757_RS37955	COG4733	cellulase activity
EP757_RS37955	COG5297	Belongs to the glycosyl hydrolase family 6
EP757_RS37965	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EP757_RS37970	COG1653	transport
EP757_RS37975	COG1175	transmembrane transport
EP757_RS37980	COG0395	ABC-type sugar transport system, permease component
EP757_RS37990	COG1136	(ABC) transporter
EP757_RS37995	COG0577	efflux transmembrane transporter activity
EP757_RS37995	COG1136	(ABC) transporter
EP757_RS38015	COG1131	(ABC) transporter
EP757_RS38030	COG2205	protein histidine kinase activity
EP757_RS38035	COG0745	RESPONSE REGULATOR receiver
EP757_RS38115	COG1174	glycine betaine transport
EP757_RS38120	COG1174	glycine betaine transport
EP757_RS38145	COG1609	Transcriptional regulator
EP757_RS38150	COG2986	histidine ammonia-lyase
EP757_RS38170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EP757_RS38175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP757_RS38190	COG1309	transcriptional regulator
EP757_RS38200	COG2205	protein histidine kinase activity
EP757_RS38205	COG0745	RESPONSE REGULATOR receiver
EP757_RS38235	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EP757_RS38255	COG1716	ATPase activity
EP757_RS38295	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
EP757_RS38300	COG0384	phenazine biosynthesis protein PhzF
EP757_RS38305	COG3467	pyridoxamine 5'-phosphate
EP757_RS38310	COG0488	(ABC) transporter
EP757_RS38325	COG1649	PFAM Uncharacterised BCR, COG1649
EP757_RS38330	COG0297	glycogen (starch) synthase activity
EP757_RS38335	COG2199	diguanylate cyclase activity
EP757_RS38335	COG2203	Gaf domain
EP757_RS38340	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EP757_RS38400	COG2501	S4 domain
EP757_RS38415	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EP757_RS38420	COG1366	Belongs to the anti-sigma-factor antagonist family
EP757_RS38425	COG1940	carbohydrate kinase activity
EP757_RS38440	COG4214	carbohydrate transport
EP757_RS38445	COG1129	ABC transporter
EP757_RS38455	COG2160	L-arabinose isomerase activity
EP757_RS38460	COG1609	Transcriptional regulator
EP757_RS38495	COG3300	MHYT domain
EP757_RS38495	COG5001	Diguanylate cyclase
EP757_RS38505	COG0577	efflux transmembrane transporter activity
EP757_RS38505	COG1136	(ABC) transporter
EP757_RS38510	COG1136	(ABC) transporter
EP757_RS38510	COG0577	efflux transmembrane transporter activity
EP757_RS38525	COG2340	Cysteine-rich secretory protein family
EP757_RS38540	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EP757_RS38560	COG2201	protein-glutamate methylesterase activity
EP757_RS38580	COG0577	efflux transmembrane transporter activity
EP757_RS38580	COG1136	(ABC) transporter
EP757_RS38590	COG2197	response regulator
EP757_RS38600	COG3551	Protein conserved in bacteria
EP757_RS38610	COG0583	DNA-binding transcription factor activity
EP757_RS38640	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EP757_RS38645	COG2154	pterin-4-alpha-carbinolamine dehydratase
EP757_RS38660	COG3119	arylsulfatase activity
EP757_RS38670	COG0251	oxidation-reduction process
EP757_RS38685	COG5278	phosphoserine phosphatase activity
EP757_RS38685	COG0840	transmembrane signaling receptor activity
EP757_RS38695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EP757_RS38720	COG1280	lysine exporter protein (LysE YggA)
EP757_RS38745	COG3842	ATPase activity
EP757_RS38755	COG3551	Protein conserved in bacteria
EP757_RS38765	COG1120	ATPase activity
EP757_RS38770	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EP757_RS38775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EP757_RS38790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EP757_RS38795	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EP757_RS38800	COG1120	ATPase activity
EP757_RS38820	COG0579	oxidoreductase
EP757_RS38825	COG1012	belongs to the aldehyde dehydrogenase family
EP757_RS38845	COG2267	carboxylic ester hydrolase activity
EP757_RS38850	COG0346	lactoylglutathione lyase activity
EP757_RS38855	COG0179	Fumarylacetoacetate (FAA) hydrolase
EP757_RS38870	COG0583	DNA-binding transcription factor activity
EP757_RS38875	COG4213	ABC transporter substrate-binding protein
EP757_RS38880	COG1172	Belongs to the binding-protein-dependent transport system permease family
EP757_RS38885	COG1129	ABC transporter
EP757_RS38905	COG2205	protein histidine kinase activity
EP757_RS38910	COG0745	RESPONSE REGULATOR receiver
EP757_RS38920	COG1017	nitric oxide dioxygenase activity
EP757_RS38920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EP757_RS38955	COG3706	GGDEF domain
EP757_RS38985	COG0577	efflux transmembrane transporter activity
EP757_RS38985	COG1136	(ABC) transporter
EP757_RS38990	COG4974	Belongs to the 'phage' integrase family
EP757_RS39085	COG4585	Histidine kinase
EP757_RS39090	COG2197	response regulator
EP757_RS39095	COG5001	Diguanylate cyclase
EP757_RS39095	COG3447	MASE1 domain protein
EP757_RS39095	COG5002	protein histidine kinase activity
EP757_RS39105	COG2200	EAL domain
EP757_RS39110	COG0318	PFAM AMP-dependent synthetase and ligase
EP757_RS39120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP757_RS39130	COG0515	serine threonine protein kinase
EP757_RS39135	COG0631	protein serine/threonine phosphatase activity
EP757_RS39150	COG3903	Transcriptional regulator
EP757_RS39150	COG3629	intracellular signal transduction
EP757_RS39200	COG0546	phosphoglycolate phosphatase activity
EP757_RS39210	COG0805	protein transport
EP757_RS39215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EP757_RS39225	COG2378	regulation of single-species biofilm formation
EP757_RS39230	COG2378	regulation of single-species biofilm formation
EP757_RS39255	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
EP757_RS39260	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
EP757_RS39265	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
EP757_RS39280	COG4122	O-methyltransferase activity
EP757_RS39290	COG1222	aaa ATPase
EP757_RS39310	COG0517	IMP dehydrogenase activity
EP757_RS39310	COG1994	Peptidase M50
EP757_RS39320	COG2197	response regulator
EP757_RS39340	COG0577	efflux transmembrane transporter activity
EP757_RS39340	COG1136	(ABC) transporter
EP757_RS39345	COG0577	efflux transmembrane transporter activity
EP757_RS39345	COG1136	(ABC) transporter
EP757_RS39400	COG4585	Histidine kinase
EP757_RS39410	COG2197	response regulator
EP757_RS39420	COG4585	Histidine kinase
EP757_RS39425	COG2197	response regulator
EP757_RS39435	COG0215	cysteine-tRNA ligase activity
EP757_RS39450	COG0588	phosphoglycerate mutase activity
EP757_RS39455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS39460	COG0667	Aldo Keto reductase
EP757_RS39475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EP757_RS39495	COG0542	response to heat
EP757_RS39545	COG0745	RESPONSE REGULATOR receiver
EP757_RS39555	COG0653	protein targeting
EP757_RS39565	COG0673	inositol 2-dehydrogenase activity
EP757_RS39570	COG0463	Glycosyl transferase, family 2
EP757_RS39595	COG1191	sigma factor activity
EP757_RS39615	COG1797	cobyrinic acid a,c-diamide synthase activity
EP757_RS39630	COG1136	(ABC) transporter
EP757_RS39630	COG0577	efflux transmembrane transporter activity
EP757_RS39635	COG1136	(ABC) transporter
EP757_RS39635	COG0577	efflux transmembrane transporter activity
EP757_RS39665	COG1070	Carbohydrate kinase
EP757_RS39720	COG1643	Atp-dependent helicase
EP757_RS39725	COG1316	TRANSCRIPTIONal
EP757_RS39730	COG0784	Response regulator, receiver
EP757_RS39735	COG5002	protein histidine kinase activity
EP757_RS39760	COG1940	carbohydrate kinase activity
EP757_RS39765	COG3467	pyridoxamine 5'-phosphate
EP757_RS39785	COG0366	Alpha amylase catalytic
EP757_RS39800	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EP757_RS39805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EP757_RS39810	COG3328	transposase activity
EP757_RS39820	COG2197	response regulator
EP757_RS39825	COG2183	response to ionizing radiation
EP757_RS39870	COG5297	Belongs to the glycosyl hydrolase family 6
EP757_RS39875	COG3447	MASE1 domain protein
EP757_RS39875	COG5001	Diguanylate cyclase
EP757_RS39875	COG5002	protein histidine kinase activity
EP757_RS39885	COG1960	acyl-CoA dehydrogenase activity
EP757_RS39900	COG0584	glycerophosphoryl diester phosphodiesterase
EP757_RS39925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EP757_RS39930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EP757_RS39940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EP757_RS39950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EP757_RS39960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EP757_RS39965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EP757_RS39995	COG0515	serine threonine protein kinase
EP757_RS40025	COG4106	trans-aconitate 2-methyltransferase activity
EP757_RS40040	COG1012	belongs to the aldehyde dehydrogenase family
EP757_RS40070	COG1802	Transcriptional regulator
EP757_RS40080	COG3866	Pectate lyase
EP757_RS40095	COG0246	Mannitol dehydrogenase
EP757_RS40100	COG1904	glucuronate isomerase
EP757_RS40105	COG0673	inositol 2-dehydrogenase activity
EP757_RS40110	COG1609	Transcriptional regulator
EP757_RS40120	COG1175	transmembrane transport
EP757_RS40125	COG0395	ABC-type sugar transport system, permease component
EP757_RS40135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EP757_RS40145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP757_RS40165	COG3458	cephalosporin-C deacetylase activity
EP757_RS40170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EP757_RS40200	COG1461	Dihydroxyacetone kinase
EP757_RS40205	COG2376	Dihydroxyacetone kinase
EP757_RS40210	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
EP757_RS40210	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EP757_RS40210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EP757_RS40235	COG0183	Belongs to the thiolase family
EP757_RS40240	COG1960	acyl-CoA dehydrogenase activity
EP757_RS40245	COG0318	PFAM AMP-dependent synthetase and ligase
EP757_RS40250	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS40270	COG1476	TRANSCRIPTIONal
EP757_RS40275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EP757_RS40300	COG3940	Belongs to the glycosyl hydrolase 43 family
EP757_RS40305	COG2199	diguanylate cyclase activity
EP757_RS40305	COG2202	Pas domain
EP757_RS40305	COG2200	EAL domain
EP757_RS40315	COG2072	flavoprotein involved in K transport
EP757_RS40330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EP757_RS40335	COG0318	PFAM AMP-dependent synthetase and ligase
EP757_RS40350	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS40360	COG0154	amidase activity
EP757_RS40380	COG4608	Belongs to the ABC transporter superfamily
EP757_RS40390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EP757_RS40395	COG0601	transmembrane transport
EP757_RS40400	COG4166	transmembrane transport
EP757_RS40410	COG0477	Major facilitator Superfamily
EP757_RS40415	COG1309	transcriptional regulator
EP757_RS40425	COG1086	Polysaccharide biosynthesis protein
EP757_RS40430	COG0489	protein tyrosine kinase activity
EP757_RS40440	COG3959	Transketolase, thiamine diphosphate binding domain
EP757_RS40445	COG3958	Transketolase
EP757_RS40455	COG1215	transferase activity, transferring glycosyl groups
EP757_RS40480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EP757_RS40555	COG1252	NADH dehydrogenase
EP757_RS40560	COG1435	thymidine kinase activity
EP757_RS40570	COG1132	(ABC) transporter
EP757_RS40575	COG1132	(ABC) transporter
EP757_RS40595	COG2301	Belongs to the HpcH HpaI aldolase family
EP757_RS40600	COG1960	acyl-CoA dehydrogenase activity
EP757_RS40665	COG1960	acyl-CoA dehydrogenase activity
EP757_RS40670	COG1012	belongs to the aldehyde dehydrogenase family
EP757_RS40685	COG1012	belongs to the aldehyde dehydrogenase family
EP757_RS40795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EP757_RS40840	COG1335	isochorismatase
EP757_RS40845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EP757_RS40850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EP757_RS40855	COG0318	PFAM AMP-dependent synthetase and ligase
EP757_RS40895	COG0395	ABC-type sugar transport system, permease component
EP757_RS40940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EP757_RS40945	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EP757_RS40985	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EP757_RS40990	COG1213	nucleotidyl transferase
EP757_RS40990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EP757_RS41020	COG1937	Protein conserved in bacteria
EP757_RS41040	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EP757_RS41045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP757_RS41070	COG1131	(ABC) transporter
EP757_RS41100	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EP757_RS41105	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EP757_RS41115	COG1414	Transcriptional regulator
EP757_RS41120	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EP757_RS41150	COG4412	M6 family metalloprotease domain protein
EP757_RS41150	COG1404	Belongs to the peptidase S8 family
EP757_RS41165	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EP757_RS41175	COG0489	protein tyrosine kinase activity
EP757_RS41175	COG3206	protein involved in exopolysaccharide biosynthesis
EP757_RS41225	COG1063	alcohol dehydrogenase
EP757_RS41255	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EP757_RS41265	COG1086	Polysaccharide biosynthesis protein
EP757_RS41270	COG0438	transferase activity, transferring glycosyl groups
EP757_RS41280	COG2197	response regulator
EP757_RS41290	COG0702	epimerase
EP757_RS41315	COG0515	serine threonine protein kinase
EP757_RS41330	COG0477	Major facilitator Superfamily
EP757_RS41340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EP757_RS41375	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS41395	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EP757_RS41400	COG4565	transcriptional regulatory protein
EP757_RS41405	COG3290	protein histidine kinase activity
EP757_RS41410	COG1301	dicarboxylic acid transport
EP757_RS41435	COG4941	Belongs to the sigma-70 factor family
EP757_RS41440	COG3795	YCII-related domain
EP757_RS41475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EP757_RS41480	COG0569	domain protein
EP757_RS41495	COG2936	dipeptidyl-peptidase activity
EP757_RS41510	COG1752	Esterase of the alpha-beta hydrolase superfamily
EP757_RS41535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EP757_RS41540	COG1216	Glycosyl transferase, family 2
EP757_RS41545	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EP757_RS41580	COG0667	Aldo Keto reductase
EP757_RS41615	COG1882	Formate acetyltransferase
EP757_RS41665	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EP757_RS41695	COG0709	Synthesizes selenophosphate from selenide and ATP
EP757_RS41710	COG1522	sequence-specific DNA binding
EP757_RS41720	COG2318	DinB family
EP757_RS41725	COG1309	transcriptional regulator
EP757_RS41730	COG1028	Short-chain dehydrogenase reductase Sdr
EP757_RS41745	COG0437	4 iron, 4 sulfur cluster binding
EP757_RS41750	COG3383	formate dehydrogenase (NAD+) activity
EP757_RS41750	COG0243	molybdopterin cofactor binding
EP757_RS41755	COG0243	molybdopterin cofactor binding
EP757_RS41755	COG3383	formate dehydrogenase (NAD+) activity
EP757_RS41790	COG2226	methyltransferase
EP757_RS41805	COG0584	glycerophosphoryl diester phosphodiesterase
EP757_RS41830	COG1309	transcriptional regulator
EP757_RS41835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP757_RS41865	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EP757_RS41930	COG0515	serine threonine protein kinase
EP757_RS41950	COG0477	Major facilitator Superfamily
EP757_RS41960	COG4585	Histidine kinase
EP757_RS41965	COG2197	response regulator
EP757_RS41970	COG2132	Multicopper oxidase
EP757_RS41985	COG0477	Major facilitator Superfamily
EP757_RS42005	COG2207	Transcriptional regulator
EP757_RS42065	COG2226	methyltransferase
EP757_RS42075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP757_RS42090	COG0024	Methionine aminopeptidase
EP757_RS42105	COG3104	oligopeptide transport
EP757_RS42110	COG4124	Belongs to the glycosyl hydrolase 26 family
EP757_RS42130	COG1175	transmembrane transport
EP757_RS42140	COG1609	Transcriptional regulator
EP757_RS42145	COG1940	carbohydrate kinase activity
EP757_RS42165	COG0384	phenazine biosynthesis protein PhzF
EP757_RS42200	COG4948	Mandelate Racemase Muconate Lactonizing
EP757_RS42205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EP757_RS42210	COG0395	ABC-type sugar transport system, permease component
EP757_RS42215	COG1175	transmembrane transport
EP757_RS42220	COG1653	transport
EP757_RS42225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EP757_RS42235	COG1414	Transcriptional regulator
EP757_RS42265	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EP757_RS42305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EP757_RS42350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EP757_RS42355	COG0659	secondary active sulfate transmembrane transporter activity
EP757_RS42365	COG0456	acetyltransferase
EP757_RS42375	COG1278	Cold shock
EP757_RS42380	COG2208	phosphoserine phosphatase activity
EP757_RS42380	COG2770	Histidine kinase
EP757_RS42435	COG0745	RESPONSE REGULATOR receiver
EP757_RS42465	COG0515	serine threonine protein kinase
EP757_RS42470	COG0210	DNA helicase
EP757_RS42485	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EP757_RS42655	COG2197	response regulator