locus-tag	class	description
ACPL_RS00010	COG0592	DNA-directed DNA polymerase activity
ACPL_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ACPL_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ACPL_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
ACPL_RS00040	COG0187	DNA topoisomerase II activity
ACPL_RS00045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ACPL_RS00070	COG2197	response regulator
ACPL_RS00075	COG4585	Histidine kinase
ACPL_RS00105	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ACPL_RS00130	COG0326	Molecular chaperone. Has ATPase activity
ACPL_RS00145	COG0439	Biotin carboxylase
ACPL_RS00150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACPL_RS00165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACPL_RS00170	COG1960	acyl-CoA dehydrogenase activity
ACPL_RS00180	COG1846	Transcriptional regulator
ACPL_RS00230	COG1716	ATPase activity
ACPL_RS00230	COG1716	ATPase activity
ACPL_RS00235	COG1716	ATPase activity
ACPL_RS00250	COG0768	penicillin binding
ACPL_RS00255	COG0515	serine threonine protein kinase
ACPL_RS00260	COG2815	serine threonine protein kinase
ACPL_RS00260	COG0515	serine threonine protein kinase
ACPL_RS00290	COG2181	nitrate reductase activity
ACPL_RS00290	COG0247	lactate metabolic process
ACPL_RS00325	COG0717	Belongs to the dCTP deaminase family
ACPL_RS00340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACPL_RS00345	COG2208	phosphoserine phosphatase activity
ACPL_RS00345	COG2770	Histidine kinase
ACPL_RS00350	COG1960	acyl-CoA dehydrogenase activity
ACPL_RS00395	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACPL_RS00400	COG0022	dehydrogenase e1 component
ACPL_RS00430	COG0443	Heat shock 70 kDa protein
ACPL_RS00435	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACPL_RS00440	COG0484	heat shock protein binding
ACPL_RS00445	COG0789	Transcriptional regulator
ACPL_RS00455	COG0475	glutathione-regulated potassium exporter activity
ACPL_RS00465	COG2814	Major facilitator Superfamily
ACPL_RS00470	COG0542	response to heat
ACPL_RS00500	COG0640	Transcriptional regulator
ACPL_RS00510	COG0586	Pfam SNARE associated Golgi protein
ACPL_RS00515	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ACPL_RS00570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACPL_RS00575	COG0151	Belongs to the GarS family
ACPL_RS00590	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACPL_RS00595	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACPL_RS00600	COG0047	phosphoribosylformylglycinamidine synthase activity
ACPL_RS00620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACPL_RS00625	COG0641	radical SAM
ACPL_RS00660	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
ACPL_RS00715	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ACPL_RS00725	COG0142	geranyltranstransferase activity
ACPL_RS00740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACPL_RS00770	COG0515	serine threonine protein kinase
ACPL_RS00775	COG1595	DNA-templated transcription, initiation
ACPL_RS00795	COG0803	Belongs to the bacterial solute-binding protein 9 family
ACPL_RS00800	COG1121	(ABC) transporter
ACPL_RS00805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACPL_RS00815	COG0640	Transcriptional regulator
ACPL_RS00820	COG0701	Predicted permease
ACPL_RS00860	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ACPL_RS00960	COG1971	Probably functions as a manganese efflux pump
ACPL_RS00990	COG5002	protein histidine kinase activity
ACPL_RS01025	COG1902	pentaerythritol trinitrate reductase activity
ACPL_RS01080	COG1131	(ABC) transporter
ACPL_RS01090	COG0671	phosphoesterase, PA-phosphatase related
ACPL_RS01095	COG0745	RESPONSE REGULATOR receiver
ACPL_RS01100	COG2205	protein histidine kinase activity
ACPL_RS01125	COG1196	nuclear chromosome segregation
ACPL_RS01125	COG0739	heme binding
ACPL_RS01125	COG0741	lytic transglycosylase activity
ACPL_RS01140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACPL_RS01160	COG4974	Belongs to the 'phage' integrase family
ACPL_RS01210	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS01225	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACPL_RS01250	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACPL_RS01255	COG2208	phosphoserine phosphatase activity
ACPL_RS01255	COG2172	sigma factor antagonist activity
ACPL_RS01255	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPL_RS01275	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACPL_RS01320	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACPL_RS01335	COG1136	(ABC) transporter
ACPL_RS01355	COG0745	RESPONSE REGULATOR receiver
ACPL_RS01360	COG0784	Response regulator, receiver
ACPL_RS01360	COG2205	protein histidine kinase activity
ACPL_RS01370	COG2172	sigma factor antagonist activity
ACPL_RS01375	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPL_RS01380	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPL_RS01390	COG1970	mechanosensitive ion channel activity
ACPL_RS01435	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ACPL_RS01440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ACPL_RS01450	COG0784	Response regulator, receiver
ACPL_RS01450	COG2205	protein histidine kinase activity
ACPL_RS01455	COG0745	RESPONSE REGULATOR receiver
ACPL_RS01475	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPL_RS01480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACPL_RS01485	COG0406	alpha-ribazole phosphatase activity
ACPL_RS01490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACPL_RS01495	COG0785	Cytochrome C biogenesis protein
ACPL_RS01505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACPL_RS01515	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACPL_RS01525	COG0163	prenyltransferase activity
ACPL_RS01550	COG0513	Belongs to the DEAD box helicase family
ACPL_RS01560	COG0791	NLP P60 protein
ACPL_RS01560	COG3883	PFAM NLP P60 protein
ACPL_RS01565	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACPL_RS01585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACPL_RS01590	COG1120	ATPase activity
ACPL_RS01620	COG3973	AAA domain
ACPL_RS01635	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACPL_RS01640	COG0667	Aldo Keto reductase
ACPL_RS01645	COG4279	zinc finger
ACPL_RS01650	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACPL_RS01665	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACPL_RS01670	COG2226	methyltransferase
ACPL_RS01690	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPL_RS01695	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPL_RS01700	COG0649	NAD binding
ACPL_RS01715	COG1034	ATP synthesis coupled electron transport
ACPL_RS01720	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACPL_RS01725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPL_RS01730	COG0839	Belongs to the complex I subunit 6 family
ACPL_RS01735	COG0713	ATP synthesis coupled electron transport
ACPL_RS01750	COG1007	ATP synthesis coupled electron transport
ACPL_RS01755	COG0142	geranyltranstransferase activity
ACPL_RS01775	COG1950	PFAM Membrane protein of
ACPL_RS01810	COG0596	Alpha beta hydrolase
ACPL_RS01825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACPL_RS01875	COG1111	helicase
ACPL_RS01875	COG1205	dead DEAH box helicase
ACPL_RS01880	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPL_RS01890	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ACPL_RS01905	COG1754	DNA topoisomerase type I activity
ACPL_RS01905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ACPL_RS01915	COG1309	transcriptional regulator
ACPL_RS01925	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACPL_RS01935	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ACPL_RS01965	COG1774	PSP1 C-terminal conserved region
ACPL_RS01995	COG1404	Belongs to the peptidase S8 family
ACPL_RS02010	COG0738	Major facilitator superfamily
ACPL_RS02055	COG1793	dna ligase
ACPL_RS02055	COG3285	dna ligase
ACPL_RS02065	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ACPL_RS02090	COG1061	Type III restriction enzyme res subunit
ACPL_RS02100	COG1278	Cold shock
ACPL_RS02105	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACPL_RS02135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACPL_RS02140	COG2814	Major facilitator Superfamily
ACPL_RS02150	COG2814	Major facilitator Superfamily
ACPL_RS02165	COG2252	PERMEase
ACPL_RS02170	COG1846	Transcriptional regulator
ACPL_RS02175	COG2814	Major facilitator Superfamily
ACPL_RS02195	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ACPL_RS02205	COG0259	pyridoxamine-phosphate oxidase activity
ACPL_RS02215	COG2017	converts alpha-aldose to the beta-anomer
ACPL_RS02245	COG3842	ATPase activity
ACPL_RS02275	COG1388	LysM domain
ACPL_RS02275	COG1134	teichoic acid transport
ACPL_RS02285	COG1309	transcriptional regulator
ACPL_RS02310	COG0477	Major facilitator Superfamily
ACPL_RS02355	COG0745	RESPONSE REGULATOR receiver
ACPL_RS02360	COG0604	alcohol dehydrogenase
ACPL_RS02365	COG3850	Histidine kinase
ACPL_RS02370	COG2197	response regulator
ACPL_RS02380	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACPL_RS02385	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACPL_RS02390	COG5001	Diguanylate cyclase
ACPL_RS02390	COG3300	MHYT domain
ACPL_RS02400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACPL_RS02420	COG0596	Alpha beta hydrolase
ACPL_RS02425	COG2119	membrane
ACPL_RS02445	COG0477	Major facilitator Superfamily
ACPL_RS02480	COG0586	Pfam SNARE associated Golgi protein
ACPL_RS02510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACPL_RS02550	COG1309	transcriptional regulator
ACPL_RS02555	COG1131	(ABC) transporter
ACPL_RS02575	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ACPL_RS02590	COG3795	YCII-related domain
ACPL_RS02595	COG4941	Belongs to the sigma-70 factor family
ACPL_RS02615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACPL_RS02620	COG2271	Major facilitator Superfamily
ACPL_RS02660	COG2971	BadF BadG BcrA BcrD
ACPL_RS02665	COG1737	Transcriptional regulator
ACPL_RS02670	COG4821	SIS domain
ACPL_RS02710	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACPL_RS02720	COG2304	oxidoreductase activity
ACPL_RS02725	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ACPL_RS02730	COG2188	Transcriptional regulator
ACPL_RS02740	COG1595	DNA-templated transcription, initiation
ACPL_RS02820	COG2409	Drug exporters of the RND superfamily
ACPL_RS02830	COG0657	acetylesterase activity
ACPL_RS02845	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACPL_RS02845	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACPL_RS02850	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACPL_RS02855	COG2199	diguanylate cyclase activity
ACPL_RS02855	COG2203	Gaf domain
ACPL_RS02855	COG2200	EAL domain
ACPL_RS02860	COG3469	chitinase activity
ACPL_RS02875	COG0583	DNA-binding transcription factor activity
ACPL_RS02885	COG1388	LysM domain
ACPL_RS02890	COG3268	Saccharopine dehydrogenase
ACPL_RS02895	COG0275	rRNA processing
ACPL_RS02930	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ACPL_RS02935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACPL_RS02940	COG2205	protein histidine kinase activity
ACPL_RS02945	COG0745	RESPONSE REGULATOR receiver
ACPL_RS02970	COG2201	protein-glutamate methylesterase activity
ACPL_RS02975	COG4251	negative regulation of phosphorylation
ACPL_RS02980	COG0784	Response regulator, receiver
ACPL_RS02985	COG0483	inositol monophosphate 1-phosphatase activity
ACPL_RS03015	COG0514	ATP-dependent DNA helicase (RecQ)
ACPL_RS03030	COG1937	Protein conserved in bacteria
ACPL_RS03055	COG0513	Belongs to the DEAD box helicase family
ACPL_RS03105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ACPL_RS03110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ACPL_RS03120	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ACPL_RS03145	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPL_RS03165	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPL_RS03170	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACPL_RS03175	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPL_RS03180	COG0839	Belongs to the complex I subunit 6 family
ACPL_RS03185	COG0713	ATP synthesis coupled electron transport
ACPL_RS03190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACPL_RS03195	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPL_RS03200	COG1007	ATP synthesis coupled electron transport
ACPL_RS03205	COG0501	Belongs to the peptidase M48B family
ACPL_RS03215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_RS03250	COG1666	GTP binding
ACPL_RS03260	COG1280	lysine exporter protein (LysE YggA)
ACPL_RS03275	COG3300	MHYT domain
ACPL_RS03275	COG5001	Diguanylate cyclase
ACPL_RS03290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACPL_RS03295	COG2030	dehydratase
ACPL_RS03320	COG0081	regulation of translation
ACPL_RS03335	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACPL_RS03340	COG0222	ribosome binding
ACPL_RS03345	COG0085	RNA polymerase activity
ACPL_RS03350	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACPL_RS03365	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACPL_RS03370	COG0049	tRNA binding
ACPL_RS03375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACPL_RS03380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACPL_RS03385	COG0051	transcription antitermination factor activity, RNA binding
ACPL_RS03390	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACPL_RS03395	COG0088	Forms part of the polypeptide exit tunnel
ACPL_RS03400	COG0089	rRNA binding
ACPL_RS03405	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACPL_RS03410	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACPL_RS03415	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACPL_RS03420	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACPL_RS03425	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACPL_RS03430	COG0255	Belongs to the universal ribosomal protein uL29 family
ACPL_RS03435	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACPL_RS03440	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACPL_RS03445	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACPL_RS03450	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACPL_RS03455	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACPL_RS03460	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACPL_RS03465	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACPL_RS03470	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACPL_RS03475	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACPL_RS03480	COG1841	ribosomal large subunit assembly
ACPL_RS03485	COG0200	Binds to the 23S rRNA
ACPL_RS03495	COG0563	adenylate kinase activity
ACPL_RS03510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACPL_RS03515	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ACPL_RS03520	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACPL_RS03525	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACPL_RS03530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACPL_RS03540	COG0203	ribosomal protein L17
ACPL_RS03545	COG0101	tRNA pseudouridine synthase activity
ACPL_RS03555	COG2813	Specifically methylates the guanine in position
ACPL_RS03560	COG0488	(ABC) transporter
ACPL_RS03565	COG0352	thiamine-phosphate diphosphorylase activity
ACPL_RS03570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACPL_RS03570	COG2022	thiamine diphosphate biosynthetic process
ACPL_RS03580	COG2022	thiamine diphosphate biosynthetic process
ACPL_RS03585	COG0352	thiamine-phosphate diphosphorylase activity
ACPL_RS03590	COG0351	phosphomethylpyrimidine kinase
ACPL_RS03595	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACPL_RS03625	COG2018	Roadblock/LC7 domain
ACPL_RS03645	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACPL_RS03650	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACPL_RS03655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACPL_RS03670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACPL_RS03685	COG0736	holo-[acyl-carrier-protein] synthase activity
ACPL_RS03695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACPL_RS03705	COG0802	atpase or kinase
ACPL_RS03710	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ACPL_RS03725	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACPL_RS03735	COG1132	(ABC) transporter
ACPL_RS03745	COG0459	protein refolding
ACPL_RS03750	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACPL_RS03760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ACPL_RS03765	COG4213	ABC transporter substrate-binding protein
ACPL_RS03775	COG4214	carbohydrate transport
ACPL_RS03810	COG2197	response regulator
ACPL_RS03825	COG0516	GMP reductase activity
ACPL_RS03835	COG1316	TRANSCRIPTIONal
ACPL_RS03840	COG0519	Catalyzes the synthesis of GMP from XMP
ACPL_RS03840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACPL_RS03845	COG1051	belongs to the nudix hydrolase family
ACPL_RS03850	COG0494	nUDIX hydrolase
ACPL_RS03855	COG1183	phosphatidylcholine synthase activity
ACPL_RS03860	COG0688	phosphatidylethanolamine metabolic process
ACPL_RS03875	COG4585	Histidine kinase
ACPL_RS03880	COG2197	response regulator
ACPL_RS03885	COG4166	transmembrane transport
ACPL_RS03890	COG0601	transmembrane transport
ACPL_RS03895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACPL_RS03900	COG0444	Belongs to the ABC transporter superfamily
ACPL_RS03905	COG4608	Belongs to the ABC transporter superfamily
ACPL_RS03910	COG1605	Chorismate mutase
ACPL_RS03915	COG0737	Belongs to the 5'-nucleotidase family
ACPL_RS03915	COG4085	toxin activity
ACPL_RS03915	COG1525	nuclease
ACPL_RS03925	COG0739	heme binding
ACPL_RS03935	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACPL_RS03940	COG0045	succinate-CoA ligase (ADP-forming) activity
ACPL_RS03960	COG0138	bifunctional purine biosynthesis protein purh
ACPL_RS03975	COG0538	isocitrate dehydrogenase activity
ACPL_RS03985	COG1349	DNA-binding transcription factor activity
ACPL_RS04005	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ACPL_RS04050	COG0489	protein tyrosine kinase activity
ACPL_RS04050	COG3206	protein involved in exopolysaccharide biosynthesis
ACPL_RS04055	COG0529	Catalyzes the synthesis of activated sulfate
ACPL_RS04075	COG1131	(ABC) transporter
ACPL_RS04085	COG0640	Transcriptional regulator
ACPL_RS04105	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ACPL_RS04110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACPL_RS04110	COG1024	Enoyl-CoA hydratase
ACPL_RS04145	COG0148	phosphopyruvate hydratase activity
ACPL_RS04160	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ACPL_RS04190	COG0714	Associated with various cellular activities
ACPL_RS04225	COG0183	Belongs to the thiolase family
ACPL_RS04250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACPL_RS04260	COG0456	acetyltransferase
ACPL_RS04265	COG1234	tRNA 3'-trailer cleavage
ACPL_RS04270	COG2326	polyphosphate kinase activity
ACPL_RS04290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACPL_RS04310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACPL_RS04315	COG0501	Belongs to the peptidase M48B family
ACPL_RS04320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACPL_RS04330	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACPL_RS04350	COG1331	Highly conserved protein containing a thioredoxin domain
ACPL_RS04360	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACPL_RS04425	COG0577	efflux transmembrane transporter activity
ACPL_RS04425	COG1136	(ABC) transporter
ACPL_RS04435	COG3629	intracellular signal transduction
ACPL_RS04435	COG3903	Transcriptional regulator
ACPL_RS04450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACPL_RS04470	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACPL_RS04475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACPL_RS04480	COG2423	ornithine cyclodeaminase activity
ACPL_RS04635	COG1609	Transcriptional regulator
ACPL_RS04650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACPL_RS04670	COG1607	acyl-coa hydrolase
ACPL_RS04680	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS04700	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
ACPL_RS04700	COG0778	Nitroreductase
ACPL_RS04705	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ACPL_RS04715	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACPL_RS04745	COG1012	belongs to the aldehyde dehydrogenase family
ACPL_RS04755	COG1515	deoxyribonuclease V activity
ACPL_RS04760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACPL_RS04765	COG2835	tetraacyldisaccharide 4'-kinase activity
ACPL_RS04795	COG0745	RESPONSE REGULATOR receiver
ACPL_RS04800	COG5002	protein histidine kinase activity
ACPL_RS04815	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ACPL_RS04825	COG0653	protein targeting
ACPL_RS04860	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACPL_RS04865	COG2884	Cell division ATP-binding protein ftsE
ACPL_RS04870	COG2177	Part of the ABC transporter FtsEX involved in
ACPL_RS04875	COG0741	lytic transglycosylase activity
ACPL_RS04875	COG1196	nuclear chromosome segregation
ACPL_RS04875	COG0739	heme binding
ACPL_RS04880	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACPL_RS05005	COG1595	DNA-templated transcription, initiation
ACPL_RS05015	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ACPL_RS05020	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ACPL_RS05040	COG1678	Uncharacterized ACR, COG1678
ACPL_RS05045	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ACPL_RS05055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_RS05075	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ACPL_RS05085	COG1459	type II secretion system
ACPL_RS05095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACPL_RS05195	COG5002	protein histidine kinase activity
ACPL_RS05195	COG5001	Diguanylate cyclase
ACPL_RS05210	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
ACPL_RS05215	COG1793	dna ligase
ACPL_RS05215	COG3285	dna ligase
ACPL_RS05220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACPL_RS05225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACPL_RS05250	COG1335	isochorismatase
ACPL_RS05255	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ACPL_RS05290	COG1234	tRNA 3'-trailer cleavage
ACPL_RS05295	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS05300	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ACPL_RS05305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACPL_RS05310	COG2986	histidine ammonia-lyase
ACPL_RS05315	COG1228	amidohydrolase
ACPL_RS05320	COG0402	S-adenosylhomocysteine deaminase activity
ACPL_RS05325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACPL_RS05330	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ACPL_RS05360	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ACPL_RS05400	COG1276	copper resistance
ACPL_RS05400	COG2372	response to copper ion
ACPL_RS05410	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ACPL_RS05455	COG3226	Transcriptional regulator
ACPL_RS05475	COG1376	ErfK ybiS ycfS ynhG family protein
ACPL_RS05490	COG4733	cellulase activity
ACPL_RS05500	COG2197	response regulator
ACPL_RS05515	COG2124	cytochrome p450
ACPL_RS05630	COG0277	FAD linked oxidase domain protein
ACPL_RS05640	COG0745	RESPONSE REGULATOR receiver
ACPL_RS05660	COG0598	Magnesium transport protein CorA
ACPL_RS05720	COG1609	Transcriptional regulator
ACPL_RS05725	COG2706	6-phosphogluconolactonase activity
ACPL_RS05740	COG2115	Belongs to the xylose isomerase family
ACPL_RS05745	COG1070	Carbohydrate kinase
ACPL_RS05755	COG0366	Alpha amylase catalytic
ACPL_RS05760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACPL_RS05785	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACPL_RS05860	COG2197	response regulator
ACPL_RS05880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACPL_RS05930	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ACPL_RS05935	COG1492	cobalamin metabolic process
ACPL_RS05940	COG0501	Belongs to the peptidase M48B family
ACPL_RS05960	COG1793	dna ligase
ACPL_RS05995	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ACPL_RS06000	COG1648	precorrin-2 dehydrogenase activity
ACPL_RS06000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACPL_RS06005	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ACPL_RS06050	COG0668	transmembrane transport
ACPL_RS06075	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ACPL_RS06090	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ACPL_RS06105	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ACPL_RS06115	COG4552	Acetyltransferase involved in intracellular survival and related
ACPL_RS06135	COG0640	Transcriptional regulator
ACPL_RS06160	COG1595	DNA-templated transcription, initiation
ACPL_RS06165	COG0640	Transcriptional regulator
ACPL_RS06170	COG2814	Major facilitator Superfamily
ACPL_RS06195	COG1063	alcohol dehydrogenase
ACPL_RS06215	COG0494	nUDIX hydrolase
ACPL_RS06230	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACPL_RS06235	COG0740	serine-type endopeptidase activity
ACPL_RS06240	COG0740	serine-type endopeptidase activity
ACPL_RS06245	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACPL_RS06285	COG0525	valine-tRNA ligase activity
ACPL_RS06290	COG0285	dihydrofolate synthase activity
ACPL_RS06310	COG0105	UTP biosynthetic process
ACPL_RS06315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACPL_RS06330	COG0596	Alpha beta hydrolase
ACPL_RS06335	COG2208	phosphoserine phosphatase activity
ACPL_RS06335	COG2172	sigma factor antagonist activity
ACPL_RS06335	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPL_RS06355	COG1530	ribonuclease E activity
ACPL_RS06365	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACPL_RS06370	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACPL_RS06375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACPL_RS06385	COG0180	Tryptophanyl-tRNA synthetase
ACPL_RS06400	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ACPL_RS06410	COG0406	alpha-ribazole phosphatase activity
ACPL_RS06420	COG1307	EDD domain protein, DegV family
ACPL_RS06430	COG2890	protein-(glutamine-N5) methyltransferase activity
ACPL_RS06435	COG1596	polysaccharide export
ACPL_RS06435	COG1555	photosystem II stabilization
ACPL_RS06440	COG2333	competence protein COMEC
ACPL_RS06440	COG0658	competence protein
ACPL_RS06455	COG0268	Binds directly to 16S ribosomal RNA
ACPL_RS06475	COG0481	GTPase activity
ACPL_RS06480	COG2261	transglycosylase associated protein
ACPL_RS06510	COG1420	regulation of RNA biosynthetic process
ACPL_RS06515	COG0484	heat shock protein binding
ACPL_RS06525	COG1695	Transcriptional regulator
ACPL_RS06540	COG0537	adenosine 5'-monophosphoramidase activity
ACPL_RS06555	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACPL_RS06570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACPL_RS06585	COG1381	Involved in DNA repair and RecF pathway recombination
ACPL_RS06590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACPL_RS06625	COG1122	ATPase activity
ACPL_RS06635	COG2267	carboxylic ester hydrolase activity
ACPL_RS06660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACPL_RS06665	COG1121	(ABC) transporter
ACPL_RS06670	COG0803	Belongs to the bacterial solute-binding protein 9 family
ACPL_RS06690	COG0423	glycine-tRNA ligase activity
ACPL_RS06700	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ACPL_RS06700	COG3608	succinylglutamate desuccinylase aspartoacylase
ACPL_RS06720	COG2018	Roadblock/LC7 domain
ACPL_RS06745	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ACPL_RS06760	COG1131	(ABC) transporter
ACPL_RS06775	COG1295	ribonuclease BN
ACPL_RS06820	COG4115	mRNA cleavage
ACPL_RS06825	COG2161	toxin-antitoxin pair type II binding
ACPL_RS06865	COG3469	chitinase activity
ACPL_RS06875	COG3250	beta-galactosidase activity
ACPL_RS06935	COG2746	aminoglycoside 3-N-acetyltransferase activity
ACPL_RS06945	COG0641	radical SAM
ACPL_RS06955	COG3903	Transcriptional regulator
ACPL_RS06955	COG3629	intracellular signal transduction
ACPL_RS06965	COG3629	intracellular signal transduction
ACPL_RS06965	COG3903	Transcriptional regulator
ACPL_RS06990	COG0018	arginyl-trna synthetase
ACPL_RS06995	COG0737	Belongs to the 5'-nucleotidase family
ACPL_RS07010	COG0515	serine threonine protein kinase
ACPL_RS07030	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ACPL_RS07045	COG3973	AAA domain
ACPL_RS07070	COG1472	Belongs to the glycosyl hydrolase 3 family
ACPL_RS07085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACPL_RS07090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACPL_RS07120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACPL_RS07125	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ACPL_RS07130	COG0432	Pfam Uncharacterised protein family UPF0047
ACPL_RS07160	COG3557	Belongs to the UPF0374 family
ACPL_RS07185	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ACPL_RS07225	COG0730	response to heat
ACPL_RS07230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACPL_RS07235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACPL_RS07250	COG2226	methyltransferase
ACPL_RS07280	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ACPL_RS07285	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACPL_RS07290	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACPL_RS07290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACPL_RS07295	COG0174	glutamine synthetase
ACPL_RS07300	COG3766	membrane
ACPL_RS07310	COG2378	regulation of single-species biofilm formation
ACPL_RS07325	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ACPL_RS07330	COG1846	Transcriptional regulator
ACPL_RS07345	COG1051	belongs to the nudix hydrolase family
ACPL_RS07410	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS07480	COG1674	ftsk spoiiie
ACPL_RS07515	COG1672	PFAM Archaeal ATPase
ACPL_RS07515	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ACPL_RS07525	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACPL_RS07530	COG0017	Asparaginyl-tRNA synthetase
ACPL_RS07540	COG0321	lipoyl(octanoyl) transferase activity
ACPL_RS07560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACPL_RS07570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACPL_RS07575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACPL_RS07580	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ACPL_RS07585	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ACPL_RS07595	COG1994	Peptidase M50
ACPL_RS07600	COG0667	Aldo Keto reductase
ACPL_RS07625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACPL_RS07640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACPL_RS07645	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ACPL_RS07650	COG1929	Belongs to the glycerate kinase type-1 family
ACPL_RS07660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACPL_RS07670	COG0425	Belongs to the sulfur carrier protein TusA family
ACPL_RS07675	COG1104	cysteine desulfurase activity
ACPL_RS07680	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACPL_RS07695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACPL_RS07750	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACPL_RS07760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACPL_RS07780	COG0501	Belongs to the peptidase M48B family
ACPL_RS07785	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS07795	COG1132	(ABC) transporter
ACPL_RS07820	COG2197	response regulator
ACPL_RS07840	COG1940	carbohydrate kinase activity
ACPL_RS07870	COG0204	Acyl-transferase
ACPL_RS07900	COG0205	6-phosphofructokinase activity
ACPL_RS07950	COG0386	Belongs to the glutathione peroxidase family
ACPL_RS07960	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ACPL_RS07980	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ACPL_RS07985	COG2815	serine threonine protein kinase
ACPL_RS07985	COG0515	serine threonine protein kinase
ACPL_RS08010	COG0142	geranyltranstransferase activity
ACPL_RS08060	COG1309	transcriptional regulator
ACPL_RS08070	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACPL_RS08075	COG1053	succinate dehydrogenase
ACPL_RS08085	COG0583	DNA-binding transcription factor activity
ACPL_RS08160	COG0587	DNA-directed DNA polymerase activity
ACPL_RS08195	COG0714	Associated with various cellular activities
ACPL_RS08200	COG0495	leucyl-tRNA aminoacylation
ACPL_RS08210	COG3442	glutamine amidotransferase
ACPL_RS08215	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACPL_RS08225	COG2001	Belongs to the MraZ family
ACPL_RS08230	COG0275	rRNA processing
ACPL_RS08245	COG0768	penicillin binding
ACPL_RS08250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACPL_RS08260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACPL_RS08270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACPL_RS08275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACPL_RS08285	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACPL_RS08295	COG1799	cell septum assembly
ACPL_RS08305	COG3599	regulation of cell shape
ACPL_RS08325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACPL_RS08345	COG0587	DNA-directed DNA polymerase activity
ACPL_RS08355	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACPL_RS08360	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACPL_RS08365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACPL_RS08370	COG0131	Imidazoleglycerol-phosphate dehydratase
ACPL_RS08385	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACPL_RS08390	COG0107	imidazoleglycerol-phosphate synthase activity
ACPL_RS08410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACPL_RS08420	COG1022	Amp-dependent synthetase and ligase
ACPL_RS08425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACPL_RS08435	COG0531	amino acid
ACPL_RS08445	COG1132	(ABC) transporter
ACPL_RS08450	COG1132	(ABC) transporter
ACPL_RS08455	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACPL_RS08470	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACPL_RS08500	COG0159	tryptophan synthase activity
ACPL_RS08510	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACPL_RS08515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACPL_RS08525	COG0070	glutamate synthase
ACPL_RS08525	COG0069	glutamate synthase activity
ACPL_RS08525	COG0067	glutamate synthase
ACPL_RS08590	COG0765	amino acid transport
ACPL_RS08620	COG2226	methyltransferase
ACPL_RS08625	COG0539	negative regulation of cytoplasmic translation
ACPL_RS08630	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ACPL_RS08630	COG0237	dephospho-CoA kinase activity
ACPL_RS08645	COG2329	Antibiotic biosynthesis monooxygenase
ACPL_RS08655	COG1217	gtp-binding protein TYPA
ACPL_RS08665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACPL_RS08670	COG0740	serine-type endopeptidase activity
ACPL_RS08685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACPL_RS08695	COG1162	GTPase activity
ACPL_RS08705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACPL_RS08715	COG0322	excinuclease ABC activity
ACPL_RS08720	COG1660	Displays ATPase and GTPase activities
ACPL_RS08730	COG1481	regulation of sporulation
ACPL_RS08735	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACPL_RS08740	COG0126	phosphoglycerate kinase activity
ACPL_RS08745	COG0149	triose-phosphate isomerase activity
ACPL_RS08750	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACPL_RS08770	COG0363	glucosamine-6-phosphate deaminase activity
ACPL_RS08785	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACPL_RS08790	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ACPL_RS08795	COG0109	protoheme IX farnesyltransferase activity
ACPL_RS08835	COG0396	ATPase activity
ACPL_RS08840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACPL_RS08845	COG0822	iron-sulfur transferase activity
ACPL_RS08880	COG0588	phosphoglycerate mutase activity
ACPL_RS08900	COG2321	neutral zinc metallopeptidase
ACPL_RS08905	COG0488	(ABC) transporter
ACPL_RS08915	COG1024	Enoyl-CoA hydratase
ACPL_RS08920	COG1132	(ABC) transporter
ACPL_RS08925	COG3663	DNA glycosylase
ACPL_RS08945	COG1309	transcriptional regulator
ACPL_RS08955	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS08975	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACPL_RS08990	COG0006	proline dipeptidase activity
ACPL_RS09020	COG0714	Associated with various cellular activities
ACPL_RS09035	COG2197	response regulator
ACPL_RS09040	COG4585	Histidine kinase
ACPL_RS09050	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACPL_RS09055	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACPL_RS09130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACPL_RS09145	COG1365	unkown
ACPL_RS09150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACPL_RS09160	COG2182	Extracellular solute-binding protein
ACPL_RS09165	COG1175	transmembrane transport
ACPL_RS09170	COG0395	ABC-type sugar transport system, permease component
ACPL_RS09175	COG1653	transport
ACPL_RS09180	COG1175	transmembrane transport
ACPL_RS09185	COG0395	ABC-type sugar transport system, permease component
ACPL_RS09190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACPL_RS09190	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACPL_RS09200	COG3265	gluconokinase activity
ACPL_RS09225	COG4585	Histidine kinase
ACPL_RS09230	COG2197	response regulator
ACPL_RS09305	COG3304	Inner membrane component domain
ACPL_RS09335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACPL_RS09340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACPL_RS09350	COG1309	transcriptional regulator
ACPL_RS09365	COG1309	transcriptional regulator
ACPL_RS09370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACPL_RS09385	COG0318	PFAM AMP-dependent synthetase and ligase
ACPL_RS09395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACPL_RS09405	COG2815	serine threonine protein kinase
ACPL_RS09405	COG0515	serine threonine protein kinase
ACPL_RS09415	COG5634	Uncharacterized conserved protein (DUF2278)
ACPL_RS09440	COG1253	flavin adenine dinucleotide binding
ACPL_RS09445	COG0840	transmembrane signaling receptor activity
ACPL_RS09470	COG3706	GGDEF domain
ACPL_RS09510	COG1175	transmembrane transport
ACPL_RS09525	COG2205	protein histidine kinase activity
ACPL_RS09530	COG2205	protein histidine kinase activity
ACPL_RS09530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACPL_RS09530	COG0784	Response regulator, receiver
ACPL_RS09530	COG2198	Histidine kinase
ACPL_RS09545	COG2205	protein histidine kinase activity
ACPL_RS09565	COG3850	Histidine kinase
ACPL_RS09565	COG5002	protein histidine kinase activity
ACPL_RS09575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACPL_RS09585	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACPL_RS09590	COG3387	PFAM Glycoside hydrolase 15-related
ACPL_RS09595	COG1525	nuclease
ACPL_RS09600	COG0667	Aldo Keto reductase
ACPL_RS09635	COG2192	nodulation
ACPL_RS09650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACPL_RS09670	COG1129	ABC transporter
ACPL_RS09680	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACPL_RS09705	COG1316	TRANSCRIPTIONal
ACPL_RS09710	COG1216	Glycosyl transferase, family 2
ACPL_RS09710	COG0463	Glycosyl transferase, family 2
ACPL_RS09765	COG1378	Sugar-specific transcriptional regulator TrmB
ACPL_RS09805	COG2070	2-Nitropropane dioxygenase
ACPL_RS09835	COG0436	Aminotransferase
ACPL_RS09870	COG0667	Aldo Keto reductase
ACPL_RS09885	COG0657	acetylesterase activity
ACPL_RS10000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACPL_RS10025	COG1196	nuclear chromosome segregation
ACPL_RS10025	COG0741	lytic transglycosylase activity
ACPL_RS10025	COG0739	heme binding
ACPL_RS10030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACPL_RS10040	COG0789	Transcriptional regulator
ACPL_RS10065	COG0243	molybdopterin cofactor binding
ACPL_RS10070	COG1752	Esterase of the alpha-beta hydrolase superfamily
ACPL_RS10095	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS10115	COG0439	Biotin carboxylase
ACPL_RS10145	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ACPL_RS10150	COG1070	Carbohydrate kinase
ACPL_RS10155	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACPL_RS10185	COG2193	ferroxidase activity
ACPL_RS10195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACPL_RS10220	COG0395	ABC-type sugar transport system, permease component
ACPL_RS10225	COG1486	melibiose metabolic process
ACPL_RS10255	COG3537	Alpha-1,2-mannosidase
ACPL_RS10280	COG0604	alcohol dehydrogenase
ACPL_RS10280	COG3321	synthase
ACPL_RS10280	COG4221	oxidoreductase activity
ACPL_RS10280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPL_RS10325	COG1960	acyl-CoA dehydrogenase activity
ACPL_RS10330	COG1063	alcohol dehydrogenase
ACPL_RS10335	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ACPL_RS10340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACPL_RS10350	COG2814	Major facilitator Superfamily
ACPL_RS10385	COG2175	clavaminate synthase activity
ACPL_RS10425	COG0840	transmembrane signaling receptor activity
ACPL_RS10430	COG2814	Major facilitator Superfamily
ACPL_RS10445	COG2197	response regulator
ACPL_RS10450	COG4585	Histidine kinase
ACPL_RS10480	COG0745	RESPONSE REGULATOR receiver
ACPL_RS10580	COG0464	growth
ACPL_RS10595	COG0714	Associated with various cellular activities
ACPL_RS10675	COG0642	Histidine kinase
ACPL_RS10710	COG2201	protein-glutamate methylesterase activity
ACPL_RS10725	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPL_RS10725	COG2172	sigma factor antagonist activity
ACPL_RS10725	COG2208	phosphoserine phosphatase activity
ACPL_RS10775	COG0714	Associated with various cellular activities
ACPL_RS10815	COG2205	protein histidine kinase activity
ACPL_RS10820	COG5002	protein histidine kinase activity
ACPL_RS10820	COG2198	Histidine kinase
ACPL_RS10820	COG0784	Response regulator, receiver
ACPL_RS10830	COG2226	methyltransferase
ACPL_RS10835	COG2814	Major facilitator Superfamily
ACPL_RS10855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACPL_RS10860	COG3537	Alpha-1,2-mannosidase
ACPL_RS10880	COG0789	Transcriptional regulator
ACPL_RS10885	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS10980	COG1609	Transcriptional regulator
ACPL_RS10995	COG0477	Major facilitator Superfamily
ACPL_RS11005	COG3347	Dehydrogenase
ACPL_RS11005	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS11010	COG1070	Carbohydrate kinase
ACPL_RS11015	COG0247	lactate metabolic process
ACPL_RS11020	COG1139	Iron-sulfur cluster binding protein
ACPL_RS11025	COG1556	Lactate utilization protein
ACPL_RS11035	COG0745	RESPONSE REGULATOR receiver
ACPL_RS11040	COG3852	Histidine kinase
ACPL_RS11055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACPL_RS11060	COG1136	(ABC) transporter
ACPL_RS11060	COG0577	efflux transmembrane transporter activity
ACPL_RS11065	COG1136	(ABC) transporter
ACPL_RS11065	COG0577	efflux transmembrane transporter activity
ACPL_RS11085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACPL_RS11100	COG4948	Mandelate Racemase Muconate Lactonizing
ACPL_RS11115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACPL_RS11180	COG0596	Alpha beta hydrolase
ACPL_RS11185	COG1116	anion transmembrane transporter activity
ACPL_RS11190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACPL_RS11195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACPL_RS11205	COG1414	Transcriptional regulator
ACPL_RS11220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACPL_RS11225	COG3706	GGDEF domain
ACPL_RS11255	COG1414	Transcriptional regulator
ACPL_RS11260	COG3485	protocatechuate 3,4-dioxygenase
ACPL_RS11265	COG3485	protocatechuate 3,4-dioxygenase
ACPL_RS11275	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACPL_RS11305	COG2197	response regulator
ACPL_RS11335	COG0039	L-malate dehydrogenase activity
ACPL_RS11360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACPL_RS11475	COG1396	sequence-specific DNA binding
ACPL_RS11490	COG1072	(Pantothenic acid kinase))
ACPL_RS11525	COG1960	acyl-CoA dehydrogenase activity
ACPL_RS11535	COG1960	acyl-CoA dehydrogenase activity
ACPL_RS11550	COG0789	Transcriptional regulator
ACPL_RS11570	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACPL_RS11575	COG1472	Belongs to the glycosyl hydrolase 3 family
ACPL_RS11580	COG1609	Transcriptional regulator
ACPL_RS11590	COG1175	transmembrane transport
ACPL_RS11595	COG0395	ABC-type sugar transport system, permease component
ACPL_RS11600	COG1501	Belongs to the glycosyl hydrolase 31 family
ACPL_RS11620	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ACPL_RS11630	COG1122	ATPase activity
ACPL_RS11645	COG0310	cobalt ion transport
ACPL_RS11650	COG5002	protein histidine kinase activity
ACPL_RS11670	COG5002	protein histidine kinase activity
ACPL_RS11690	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACPL_RS11700	COG1129	ABC transporter
ACPL_RS11705	COG1879	ABC-type sugar transport system periplasmic component
ACPL_RS11720	COG0483	inositol monophosphate 1-phosphatase activity
ACPL_RS11725	COG0515	serine threonine protein kinase
ACPL_RS11725	COG2815	serine threonine protein kinase
ACPL_RS11745	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACPL_RS11750	COG1012	belongs to the aldehyde dehydrogenase family
ACPL_RS11755	COG3842	ATPase activity
ACPL_RS11760	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ACPL_RS11765	COG1176	ABC-type spermidine putrescine transport system, permease component I
ACPL_RS11770	COG1177	transmembrane transport
ACPL_RS11775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACPL_RS11780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACPL_RS11785	COG0789	Transcriptional regulator
ACPL_RS11795	COG0745	RESPONSE REGULATOR receiver
ACPL_RS11805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACPL_RS11820	COG1012	belongs to the aldehyde dehydrogenase family
ACPL_RS11825	COG2208	phosphoserine phosphatase activity
ACPL_RS11830	COG1472	Belongs to the glycosyl hydrolase 3 family
ACPL_RS11840	COG1175	transmembrane transport
ACPL_RS11850	COG1609	Transcriptional regulator
ACPL_RS11855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_RS11860	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACPL_RS11880	COG0840	transmembrane signaling receptor activity
ACPL_RS11885	COG3191	aminopeptidase activity
ACPL_RS11905	COG0702	epimerase
ACPL_RS11910	COG1733	regulation of RNA biosynthetic process
ACPL_RS11930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACPL_RS11935	COG1024	Enoyl-CoA hydratase
ACPL_RS11935	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACPL_RS11940	COG0183	Belongs to the thiolase family
ACPL_RS11945	COG1960	acyl-CoA dehydrogenase activity
ACPL_RS11965	COG1074	ATP-dependent DNA helicase activity
ACPL_RS11965	COG1074	ATP-dependent DNA helicase activity
ACPL_RS11995	COG2197	response regulator
ACPL_RS12000	COG4585	Histidine kinase
ACPL_RS12020	COG0601	transmembrane transport
ACPL_RS12025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACPL_RS12040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_RS12050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_RS12080	COG0656	L-ascorbic acid biosynthetic process
ACPL_RS12120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACPL_RS12125	COG1126	abc transporter atp-binding protein
ACPL_RS12130	COG0765	amino acid transport
ACPL_RS12135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACPL_RS12140	COG4521	taurine ABC transporter
ACPL_RS12155	COG0366	Alpha amylase catalytic
ACPL_RS12165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_RS12170	COG2409	Drug exporters of the RND superfamily
ACPL_RS12190	COG1132	(ABC) transporter
ACPL_RS12205	COG0372	Belongs to the citrate synthase family
ACPL_RS12220	COG0596	Alpha beta hydrolase
ACPL_RS12220	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACPL_RS12260	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACPL_RS12265	COG2146	nitrite reductase [NAD(P)H] activity
ACPL_RS12270	COG2223	nitrite transmembrane transporter activity
ACPL_RS12295	COG1136	(ABC) transporter
ACPL_RS12300	COG1136	(ABC) transporter
ACPL_RS12305	COG0395	ABC-type sugar transport system, permease component
ACPL_RS12310	COG1175	transmembrane transport
ACPL_RS12315	COG1653	transport
ACPL_RS12320	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ACPL_RS12330	COG5297	Belongs to the glycosyl hydrolase family 6
ACPL_RS12330	COG4733	cellulase activity
ACPL_RS12345	COG0009	L-threonylcarbamoyladenylate synthase
ACPL_RS12390	COG0583	DNA-binding transcription factor activity
ACPL_RS12415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_RS12440	COG0024	Methionine aminopeptidase
ACPL_RS12470	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACPL_RS12470	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ACPL_RS12475	COG0494	nUDIX hydrolase
ACPL_RS12500	COG0456	acetyltransferase
ACPL_RS12510	COG1742	UPF0060 membrane protein
ACPL_RS12635	COG0859	PFAM glycosyl transferase family 9
ACPL_RS12645	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACPL_RS12645	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACPL_RS12650	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS12660	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ACPL_RS12670	COG2192	nodulation
ACPL_RS12715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_RS12730	COG3293	Transposase
ACPL_RS12735	COG3415	Transposase
ACPL_RS12735	COG2801	Transposase and inactivated derivatives
ACPL_RS12755	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ACPL_RS12765	COG3973	AAA domain
ACPL_RS12775	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACPL_RS12800	COG0531	amino acid
ACPL_RS12840	COG0714	Associated with various cellular activities
ACPL_RS12865	COG0028	Belongs to the TPP enzyme family
ACPL_RS12890	COG0783	Belongs to the Dps family
ACPL_RS12895	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS12910	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ACPL_RS12915	COG0242	peptide deformylase activity
ACPL_RS12950	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACPL_RS12965	COG0436	Aminotransferase
ACPL_RS12995	COG3300	MHYT domain
ACPL_RS12995	COG5001	Diguanylate cyclase
ACPL_RS13010	COG1690	Belongs to the RtcB family
ACPL_RS13025	COG0701	Predicted permease
ACPL_RS13035	COG2201	protein-glutamate methylesterase activity
ACPL_RS13050	COG2201	protein-glutamate methylesterase activity
ACPL_RS13060	COG3250	beta-galactosidase activity
ACPL_RS13080	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ACPL_RS13085	COG1984	allophanate hydrolase subunit 2
ACPL_RS13125	COG0596	Alpha beta hydrolase
ACPL_RS13130	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS13140	COG0411	ABC transporter
ACPL_RS13160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_RS13165	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ACPL_RS13175	COG0183	Belongs to the thiolase family
ACPL_RS13180	COG0583	DNA-binding transcription factor activity
ACPL_RS13190	COG0488	(ABC) transporter
ACPL_RS13215	COG0693	protein deglycase activity
ACPL_RS13245	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS13270	COG2080	2 iron, 2 sulfur cluster binding
ACPL_RS13275	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ACPL_RS13280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACPL_RS13290	COG4213	ABC transporter substrate-binding protein
ACPL_RS13295	COG4214	carbohydrate transport
ACPL_RS13310	COG1136	(ABC) transporter
ACPL_RS13310	COG0577	efflux transmembrane transporter activity
ACPL_RS13325	COG0778	Nitroreductase
ACPL_RS13340	COG0640	Transcriptional regulator
ACPL_RS13385	COG0463	Glycosyl transferase, family 2
ACPL_RS13400	COG1607	acyl-coa hydrolase
ACPL_RS13405	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACPL_RS13410	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ACPL_RS13415	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ACPL_RS13420	COG0604	alcohol dehydrogenase
ACPL_RS13425	COG1509	lysine 2,3-aminomutase activity
ACPL_RS13465	COG1960	acyl-CoA dehydrogenase activity
ACPL_RS13470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACPL_RS13505	COG3511	phospholipase C
ACPL_RS13510	COG3300	MHYT domain
ACPL_RS13510	COG5001	Diguanylate cyclase
ACPL_RS13525	COG3706	GGDEF domain
ACPL_RS13560	COG1324	tolerance protein
ACPL_RS13570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACPL_RS13635	COG0667	Aldo Keto reductase
ACPL_RS13660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACPL_RS13700	COG2816	NAD+ diphosphatase activity
ACPL_RS13710	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ACPL_RS13730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACPL_RS13765	COG1476	TRANSCRIPTIONal
ACPL_RS13775	COG3022	response to hydroperoxide
ACPL_RS13805	COG4279	zinc finger
ACPL_RS13810	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACPL_RS13820	COG3300	MHYT domain
ACPL_RS13820	COG5001	Diguanylate cyclase
ACPL_RS13840	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACPL_RS13850	COG2124	cytochrome p450
ACPL_RS13865	COG0531	amino acid
ACPL_RS13870	COG0515	serine threonine protein kinase
ACPL_RS13895	COG1408	metallophosphoesterase
ACPL_RS13900	COG1132	(ABC) transporter
ACPL_RS13905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACPL_RS13920	COG2226	methyltransferase
ACPL_RS13925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACPL_RS13930	COG2151	metal-sulfur cluster biosynthetic enzyme
ACPL_RS13940	COG3396	Phenylacetate-CoA oxygenase
ACPL_RS13945	COG3460	Phenylacetate-CoA oxygenase
ACPL_RS13950	COG3396	Phenylacetate-CoA oxygenase
ACPL_RS13965	COG0673	inositol 2-dehydrogenase activity
ACPL_RS13985	COG1082	Xylose isomerase domain protein TIM barrel
ACPL_RS13990	COG3962	Belongs to the TPP enzyme family
ACPL_RS13995	COG3718	enzyme involved in inositol metabolism
ACPL_RS14010	COG3384	dioxygenase
ACPL_RS14035	COG1136	(ABC) transporter
ACPL_RS14035	COG0577	efflux transmembrane transporter activity
ACPL_RS14040	COG1136	(ABC) transporter
ACPL_RS14050	COG2205	protein histidine kinase activity
ACPL_RS14055	COG0745	RESPONSE REGULATOR receiver
ACPL_RS14090	COG0406	alpha-ribazole phosphatase activity
ACPL_RS14100	COG1609	Transcriptional regulator
ACPL_RS14125	COG1940	carbohydrate kinase activity
ACPL_RS14150	COG4608	Belongs to the ABC transporter superfamily
ACPL_RS14155	COG0444	Belongs to the ABC transporter superfamily
ACPL_RS14160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACPL_RS14165	COG0601	transmembrane transport
ACPL_RS14180	COG0745	RESPONSE REGULATOR receiver
ACPL_RS14185	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ACPL_RS14215	COG2076	Multidrug Resistance protein
ACPL_RS14225	COG1309	transcriptional regulator
ACPL_RS14260	COG0515	serine threonine protein kinase
ACPL_RS14280	COG0166	Belongs to the GPI family
ACPL_RS14285	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ACPL_RS14345	COG3328	transposase activity
ACPL_RS14355	COG1228	amidohydrolase
ACPL_RS14360	COG1620	l-lactate permease
ACPL_RS14405	COG3693	PFAM glycoside hydrolase, family 10
ACPL_RS14415	COG3693	PFAM glycoside hydrolase, family 10
ACPL_RS14430	COG3507	Belongs to the glycosyl hydrolase 43 family
ACPL_RS14435	COG3345	alpha-galactosidase
ACPL_RS14450	COG5297	Belongs to the glycosyl hydrolase family 6
ACPL_RS14485	COG2205	protein histidine kinase activity
ACPL_RS14490	COG0745	RESPONSE REGULATOR receiver
ACPL_RS14500	COG0133	tryptophan synthase activity
ACPL_RS14505	COG0159	tryptophan synthase activity
ACPL_RS14510	COG2188	Transcriptional regulator
ACPL_RS14535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACPL_RS14540	COG3883	PFAM NLP P60 protein
ACPL_RS14540	COG0791	NLP P60 protein
ACPL_RS14545	COG0501	Belongs to the peptidase M48B family
ACPL_RS14555	COG1271	oxidase subunit
ACPL_RS14560	COG1294	oxidase, subunit
ACPL_RS14580	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACPL_RS14585	COG0477	Major facilitator Superfamily
ACPL_RS14630	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ACPL_RS14645	COG1309	transcriptional regulator
ACPL_RS14670	COG0326	Molecular chaperone. Has ATPase activity
ACPL_RS14700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACPL_RS14720	COG0297	glycogen (starch) synthase activity
ACPL_RS14740	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACPL_RS14750	COG0514	ATP-dependent DNA helicase (RecQ)
ACPL_RS14765	COG0574	Belongs to the PEP-utilizing enzyme family
ACPL_RS14765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACPL_RS14775	COG0277	FAD linked oxidase domain protein
ACPL_RS14780	COG0277	FAD linked oxidase domain protein
ACPL_RS14785	COG0247	lactate metabolic process
ACPL_RS14790	COG2409	Drug exporters of the RND superfamily
ACPL_RS14800	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACPL_RS14805	COG4213	ABC transporter substrate-binding protein
ACPL_RS14845	COG0515	serine threonine protein kinase
ACPL_RS14845	COG2815	serine threonine protein kinase
ACPL_RS14890	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ACPL_RS14910	COG1522	sequence-specific DNA binding
ACPL_RS14985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPL_RS15000	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACPL_RS15005	COG0022	dehydrogenase e1 component
ACPL_RS15010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ACPL_RS15015	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACPL_RS15040	COG0673	inositol 2-dehydrogenase activity
ACPL_RS15045	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACPL_RS15050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACPL_RS15060	COG2226	methyltransferase
ACPL_RS15075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACPL_RS15090	COG0456	acetyltransferase
ACPL_RS15095	COG0247	lactate metabolic process
ACPL_RS15095	COG0277	FAD linked oxidase domain protein
ACPL_RS15120	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ACPL_RS15125	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ACPL_RS15130	COG2319	Wd-40 repeat
ACPL_RS15155	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACPL_RS15170	COG4677	pectinesterase activity
ACPL_RS15230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_RS15235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_RS15290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACPL_RS15300	COG4585	Histidine kinase
ACPL_RS15305	COG2197	response regulator
ACPL_RS15350	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ACPL_RS15355	COG1737	Transcriptional regulator
ACPL_RS15360	COG3876	Protein conserved in bacteria
ACPL_RS15365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ACPL_RS15370	COG1653	transport
ACPL_RS15375	COG1175	transmembrane transport
ACPL_RS15380	COG0395	ABC-type sugar transport system, permease component
ACPL_RS15405	COG2205	protein histidine kinase activity
ACPL_RS15410	COG0745	RESPONSE REGULATOR receiver
ACPL_RS15435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACPL_RS15440	COG1131	(ABC) transporter
ACPL_RS15475	COG2304	oxidoreductase activity
ACPL_RS15485	COG2197	response regulator
ACPL_RS15505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACPL_RS15510	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS15565	COG3287	FIST C domain
ACPL_RS15565	COG2200	EAL domain
ACPL_RS15565	COG2199	diguanylate cyclase activity
ACPL_RS15650	COG0431	NADPH-dependent FMN reductase
ACPL_RS15655	COG3795	YCII-related domain
ACPL_RS15660	COG4941	Belongs to the sigma-70 factor family
ACPL_RS15690	COG0387	Pfam Sodium calcium exchanger
ACPL_RS15705	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ACPL_RS15705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACPL_RS15730	COG0745	RESPONSE REGULATOR receiver
ACPL_RS15735	COG2205	protein histidine kinase activity
ACPL_RS15740	COG0667	Aldo Keto reductase
ACPL_RS15780	COG1131	(ABC) transporter
ACPL_RS15800	COG1968	undecaprenyl-diphosphatase activity
ACPL_RS15815	COG1011	Hydrolase
ACPL_RS15830	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ACPL_RS15835	COG0586	Pfam SNARE associated Golgi protein
ACPL_RS15940	COG2755	lipolytic protein G-D-S-L family
ACPL_RS15995	COG2201	protein-glutamate methylesterase activity
ACPL_RS16000	COG2205	protein histidine kinase activity
ACPL_RS16005	COG0745	RESPONSE REGULATOR receiver
ACPL_RS16070	COG2814	Major facilitator Superfamily
ACPL_RS16155	COG5002	protein histidine kinase activity
ACPL_RS16210	COG5001	Diguanylate cyclase
ACPL_RS16210	COG5002	protein histidine kinase activity
ACPL_RS16210	COG3447	MASE1 domain protein
ACPL_RS16255	COG3511	phospholipase C
ACPL_RS16285	COG1606	tRNA processing
ACPL_RS16380	COG4941	Belongs to the sigma-70 factor family
ACPL_RS16405	COG3409	Peptidoglycan-binding domain 1 protein
ACPL_RS16415	COG5001	Diguanylate cyclase
ACPL_RS16425	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ACPL_RS16455	COG0443	Heat shock 70 kDa protein
ACPL_RS16475	COG5002	protein histidine kinase activity
ACPL_RS16480	COG2203	Gaf domain
ACPL_RS16480	COG2199	diguanylate cyclase activity
ACPL_RS16485	COG0745	RESPONSE REGULATOR receiver
ACPL_RS16570	COG1215	transferase activity, transferring glycosyl groups
ACPL_RS16575	COG5002	protein histidine kinase activity
ACPL_RS16580	COG0300	oxidoreductase activity
ACPL_RS16595	COG0840	transmembrane signaling receptor activity
ACPL_RS16615	COG1295	ribonuclease BN
ACPL_RS16620	COG1309	transcriptional regulator
ACPL_RS16655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACPL_RS16660	COG2205	protein histidine kinase activity
ACPL_RS16665	COG5002	protein histidine kinase activity
ACPL_RS16690	COG2815	serine threonine protein kinase
ACPL_RS16690	COG0515	serine threonine protein kinase
ACPL_RS16820	COG1090	epimerase
ACPL_RS16900	COG3629	intracellular signal transduction
ACPL_RS16900	COG3903	Transcriptional regulator
ACPL_RS16915	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACPL_RS16920	COG4251	negative regulation of phosphorylation
ACPL_RS16960	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
ACPL_RS16965	COG5002	protein histidine kinase activity
ACPL_RS16980	COG1982	Orn Lys Arg decarboxylase major
ACPL_RS16985	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACPL_RS17025	COG2963	transposase activity
ACPL_RS17030	COG2801	Transposase and inactivated derivatives
ACPL_RS17095	COG0515	serine threonine protein kinase
ACPL_RS17140	COG2197	response regulator
ACPL_RS17185	COG1136	(ABC) transporter
ACPL_RS17185	COG0577	efflux transmembrane transporter activity
ACPL_RS17190	COG4585	Histidine kinase
ACPL_RS17215	COG0492	ferredoxin-NADP+ reductase activity
ACPL_RS17265	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACPL_RS17280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACPL_RS17280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACPL_RS17320	COG1335	isochorismatase
ACPL_RS17330	COG2267	carboxylic ester hydrolase activity
ACPL_RS17340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACPL_RS17390	COG2319	Wd-40 repeat
ACPL_RS17395	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACPL_RS17420	COG2815	serine threonine protein kinase
ACPL_RS17420	COG0515	serine threonine protein kinase
ACPL_RS17435	COG1609	Transcriptional regulator
ACPL_RS17535	COG0840	transmembrane signaling receptor activity
ACPL_RS17560	COG4124	Belongs to the glycosyl hydrolase 26 family
ACPL_RS17570	COG1940	carbohydrate kinase activity
ACPL_RS17585	COG1846	Transcriptional regulator
ACPL_RS17590	COG3387	PFAM Glycoside hydrolase 15-related
ACPL_RS17600	COG3940	Belongs to the glycosyl hydrolase 43 family
ACPL_RS17630	COG1131	(ABC) transporter
ACPL_RS17635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACPL_RS17650	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ACPL_RS17665	COG0561	phosphatase activity
ACPL_RS17675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACPL_RS17690	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS17700	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACPL_RS17705	COG1088	dTDP-glucose 4,6-dehydratase activity
ACPL_RS17710	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ACPL_RS17725	COG0395	ABC-type sugar transport system, permease component
ACPL_RS17730	COG1175	transmembrane transport
ACPL_RS17750	COG0702	epimerase
ACPL_RS17755	COG1733	regulation of RNA biosynthetic process
ACPL_RS17800	COG4251	negative regulation of phosphorylation
ACPL_RS17810	COG3321	synthase
ACPL_RS17810	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS17810	COG0604	alcohol dehydrogenase
ACPL_RS17835	COG2205	protein histidine kinase activity
ACPL_RS17835	COG3437	response regulator, receiver
ACPL_RS17835	COG3850	Histidine kinase
ACPL_RS17835	COG4999	Histidine kinase
ACPL_RS17845	COG0840	transmembrane signaling receptor activity
ACPL_RS17850	COG1744	ABC transporter substrate-binding protein PnrA-like
ACPL_RS17855	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACPL_RS17875	COG0640	Transcriptional regulator
ACPL_RS17950	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ACPL_RS17950	COG1918	ferrous iron import across plasma membrane
ACPL_RS17955	COG1278	Cold shock
ACPL_RS17970	COG3979	chitinase
ACPL_RS17975	COG3469	chitinase activity
ACPL_RS18000	COG0745	RESPONSE REGULATOR receiver
ACPL_RS18005	COG2205	protein histidine kinase activity
ACPL_RS18010	COG2409	Drug exporters of the RND superfamily
ACPL_RS18085	COG1597	lipid kinase activity
ACPL_RS18150	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ACPL_RS18165	COG2755	lipolytic protein G-D-S-L family
ACPL_RS18185	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPL_RS18185	COG2172	sigma factor antagonist activity
ACPL_RS18185	COG2208	phosphoserine phosphatase activity
ACPL_RS18200	COG0765	amino acid transport
ACPL_RS18250	COG2261	transglycosylase associated protein
ACPL_RS18290	COG4172	Belongs to the ABC transporter superfamily
ACPL_RS18310	COG1902	pentaerythritol trinitrate reductase activity
ACPL_RS18355	COG4585	Histidine kinase
ACPL_RS18375	COG1136	(ABC) transporter
ACPL_RS18475	COG3693	PFAM glycoside hydrolase, family 10
ACPL_RS18475	COG3507	Belongs to the glycosyl hydrolase 43 family
ACPL_RS18475	COG2382	esterase
ACPL_RS18495	COG0519	Catalyzes the synthesis of GMP from XMP
ACPL_RS18500	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ACPL_RS18505	COG0596	Alpha beta hydrolase
ACPL_RS18515	COG2197	response regulator
ACPL_RS18520	COG4585	Histidine kinase
ACPL_RS18610	COG1609	Transcriptional regulator
ACPL_RS18625	COG1175	transmembrane transport
ACPL_RS18630	COG0395	ABC-type sugar transport system, permease component
ACPL_RS18645	COG1132	(ABC) transporter
ACPL_RS18665	COG2259	Doxx family
ACPL_RS18715	COG0583	DNA-binding transcription factor activity
ACPL_RS18735	COG2226	methyltransferase
ACPL_RS18755	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS18805	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ACPL_RS18810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACPL_RS18815	COG1414	Transcriptional regulator
ACPL_RS18820	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACPL_RS18825	COG4941	Belongs to the sigma-70 factor family
ACPL_RS18830	COG3795	YCII-related domain
ACPL_RS18840	COG2072	flavoprotein involved in K transport
ACPL_RS18875	COG5001	Diguanylate cyclase
ACPL_RS18885	COG2816	NAD+ diphosphatase activity
ACPL_RS18995	COG0142	geranyltranstransferase activity
ACPL_RS19000	COG0477	Major facilitator Superfamily
ACPL_RS19010	COG0531	amino acid
ACPL_RS19020	COG0583	DNA-binding transcription factor activity
ACPL_RS19025	COG0483	inositol monophosphate 1-phosphatase activity
ACPL_RS19100	COG2124	cytochrome p450
ACPL_RS19110	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ACPL_RS19125	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACPL_RS19175	COG0628	permease
ACPL_RS19205	COG2909	trisaccharide binding
ACPL_RS19215	COG2909	trisaccharide binding
ACPL_RS19230	COG0531	amino acid
ACPL_RS19235	COG2235	arginine
ACPL_RS19240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACPL_RS19245	COG0549	Belongs to the carbamate kinase family
ACPL_RS19280	COG0477	Major facilitator Superfamily
ACPL_RS19305	COG1597	lipid kinase activity
ACPL_RS19360	COG0531	amino acid
ACPL_RS19375	COG0477	Major facilitator Superfamily
ACPL_RS19400	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACPL_RS19405	COG0406	alpha-ribazole phosphatase activity
ACPL_RS19430	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACPL_RS19445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACPL_RS19485	COG0640	Transcriptional regulator
ACPL_RS19495	COG0745	RESPONSE REGULATOR receiver
ACPL_RS19500	COG5002	protein histidine kinase activity
ACPL_RS19530	COG0789	Transcriptional regulator
ACPL_RS19605	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ACPL_RS19605	COG1672	PFAM Archaeal ATPase
ACPL_RS19615	COG3173	Aminoglycoside phosphotransferase
ACPL_RS19620	COG1309	transcriptional regulator
ACPL_RS19640	COG0515	serine threonine protein kinase
ACPL_RS19725	COG2770	Histidine kinase
ACPL_RS19725	COG2208	phosphoserine phosphatase activity
ACPL_RS19745	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ACPL_RS19840	COG2197	response regulator
ACPL_RS19855	COG4104	PAAR repeat-containing protein
ACPL_RS19865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACPL_RS19895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_RS19905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPL_RS19925	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACPL_RS19930	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACPL_RS19935	COG2197	response regulator
ACPL_RS19960	COG1595	DNA-templated transcription, initiation
ACPL_RS19980	COG0463	Glycosyl transferase, family 2
ACPL_RS20000	COG0076	glutamate decarboxylase activity
ACPL_RS20045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACPL_RS20050	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACPL_RS20060	COG2020	methyltransferase activity
ACPL_RS20065	COG1556	Lactate utilization protein
ACPL_RS20070	COG1139	Iron-sulfur cluster binding protein
ACPL_RS20075	COG0247	lactate metabolic process
ACPL_RS20080	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACPL_RS20090	COG1129	ABC transporter
ACPL_RS20095	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACPL_RS20110	COG2186	Transcriptional regulator
ACPL_RS20125	COG2186	Transcriptional regulator
ACPL_RS20130	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS20185	COG2186	Transcriptional regulator
ACPL_RS20195	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS20205	COG2186	Transcriptional regulator
ACPL_RS20210	COG2267	carboxylic ester hydrolase activity
ACPL_RS20215	COG5002	protein histidine kinase activity
ACPL_RS20220	COG0745	RESPONSE REGULATOR receiver
ACPL_RS20235	COG1136	(ABC) transporter
ACPL_RS20235	COG0577	efflux transmembrane transporter activity
ACPL_RS20240	COG1136	(ABC) transporter
ACPL_RS20240	COG0577	efflux transmembrane transporter activity
ACPL_RS20265	COG0640	Transcriptional regulator
ACPL_RS20305	COG2226	methyltransferase
ACPL_RS20320	COG1595	DNA-templated transcription, initiation
ACPL_RS20365	COG3795	YCII-related domain
ACPL_RS20370	COG4941	Belongs to the sigma-70 factor family
ACPL_RS20425	COG1309	transcriptional regulator
ACPL_RS20440	COG2197	response regulator
ACPL_RS20445	COG4585	Histidine kinase
ACPL_RS20460	COG2267	carboxylic ester hydrolase activity
ACPL_RS20470	COG3795	YCII-related domain
ACPL_RS20475	COG4941	Belongs to the sigma-70 factor family
ACPL_RS20500	COG0583	DNA-binding transcription factor activity
ACPL_RS20515	COG1942	4-Oxalocrotonate Tautomerase
ACPL_RS20540	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPL_RS20540	COG2208	phosphoserine phosphatase activity
ACPL_RS20540	COG2172	sigma factor antagonist activity
ACPL_RS20565	COG4221	oxidoreductase activity
ACPL_RS20630	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS20680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACPL_RS20710	COG1131	(ABC) transporter
ACPL_RS20715	COG0842	Transport permease protein
ACPL_RS20720	COG4585	Histidine kinase
ACPL_RS20725	COG2197	response regulator
ACPL_RS20730	COG1191	sigma factor activity
ACPL_RS20740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACPL_RS20745	COG0488	(ABC) transporter
ACPL_RS20750	COG4974	Belongs to the 'phage' integrase family
ACPL_RS20755	COG1968	undecaprenyl-diphosphatase activity
ACPL_RS20775	COG4974	Belongs to the 'phage' integrase family
ACPL_RS20780	COG0823	Involved in the tonB-independent uptake of proteins
ACPL_RS20780	COG1506	peptidase
ACPL_RS20790	COG2226	methyltransferase
ACPL_RS20850	COG1522	sequence-specific DNA binding
ACPL_RS20865	COG0667	Aldo Keto reductase
ACPL_RS20905	COG2197	response regulator
ACPL_RS20925	COG2270	Major facilitator Superfamily
ACPL_RS20980	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ACPL_RS20990	COG4702	Belongs to the UPF0303 family
ACPL_RS21010	COG1846	Transcriptional regulator
ACPL_RS21015	COG1764	response to oxidative stress
ACPL_RS21075	COG0019	diaminopimelate decarboxylase activity
ACPL_RS21125	COG0667	Aldo Keto reductase
ACPL_RS21150	COG0714	Associated with various cellular activities
ACPL_RS21180	COG4221	oxidoreductase activity
ACPL_RS21250	COG0242	peptide deformylase activity
ACPL_RS21265	COG1595	DNA-templated transcription, initiation
ACPL_RS21270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACPL_RS21280	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACPL_RS21280	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACPL_RS21285	COG0667	Aldo Keto reductase
ACPL_RS21300	COG2226	methyltransferase
ACPL_RS21360	COG0672	)-iron permease
ACPL_RS21365	COG2822	iron ion transport
ACPL_RS21370	COG2837	iron assimilation
ACPL_RS21460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACPL_RS21495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACPL_RS21525	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACPL_RS21550	COG1278	Cold shock
ACPL_RS21565	COG2197	response regulator
ACPL_RS21645	COG0346	lactoylglutathione lyase activity
ACPL_RS21655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACPL_RS21660	COG0840	transmembrane signaling receptor activity
ACPL_RS21725	COG1819	glycosyl
ACPL_RS21745	COG1024	Enoyl-CoA hydratase
ACPL_RS21760	COG1024	Enoyl-CoA hydratase
ACPL_RS21765	COG1902	pentaerythritol trinitrate reductase activity
ACPL_RS21765	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACPL_RS21775	COG2814	Major facilitator Superfamily
ACPL_RS21810	COG1760	l-serine dehydratase
ACPL_RS21815	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACPL_RS21850	COG1733	regulation of RNA biosynthetic process
ACPL_RS21860	COG1309	transcriptional regulator
ACPL_RS21885	COG1132	(ABC) transporter
ACPL_RS21890	COG1132	(ABC) transporter
ACPL_RS21900	COG0515	serine threonine protein kinase
ACPL_RS21945	COG3415	Transposase
ACPL_RS21945	COG2801	Transposase and inactivated derivatives
ACPL_RS21965	COG0318	PFAM AMP-dependent synthetase and ligase
ACPL_RS21975	COG5001	Diguanylate cyclase
ACPL_RS22030	COG2197	response regulator
ACPL_RS22055	COG1733	regulation of RNA biosynthetic process
ACPL_RS22060	COG2910	NAD(P)H-binding
ACPL_RS22095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_RS22165	COG1881	PFAM PEBP family protein
ACPL_RS22205	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACPL_RS22220	COG0640	Transcriptional regulator
ACPL_RS22260	COG0300	oxidoreductase activity
ACPL_RS22265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACPL_RS22265	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACPL_RS22290	COG5002	protein histidine kinase activity
ACPL_RS22300	COG2205	protein histidine kinase activity
ACPL_RS22300	COG2202	Pas domain
ACPL_RS22305	COG0395	ABC-type sugar transport system, permease component
ACPL_RS22310	COG1175	transmembrane transport
ACPL_RS22370	COG0596	Alpha beta hydrolase
ACPL_RS22405	COG3467	pyridoxamine 5'-phosphate
ACPL_RS22420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_RS22440	COG0640	Transcriptional regulator
ACPL_RS22450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACPL_RS22505	COG2721	sulfolactate sulfo-lyase activity
ACPL_RS22525	COG1609	Transcriptional regulator
ACPL_RS22540	COG0784	Response regulator, receiver
ACPL_RS22550	COG1278	Cold shock
ACPL_RS22560	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACPL_RS22575	COG1260	myo-inositol-1-phosphate synthase
ACPL_RS22590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACPL_RS22600	COG0583	DNA-binding transcription factor activity
ACPL_RS22655	COG5001	Diguanylate cyclase
ACPL_RS22685	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS22690	COG2890	protein-(glutamine-N5) methyltransferase activity
ACPL_RS22695	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACPL_RS22745	COG5002	protein histidine kinase activity
ACPL_RS22750	COG0745	RESPONSE REGULATOR receiver
ACPL_RS22780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACPL_RS22855	COG5001	Diguanylate cyclase
ACPL_RS22855	COG3300	MHYT domain
ACPL_RS22860	COG1404	Belongs to the peptidase S8 family
ACPL_RS22865	COG4251	negative regulation of phosphorylation
ACPL_RS22870	COG1982	Orn Lys Arg decarboxylase major
ACPL_RS22890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACPL_RS22900	COG0778	Nitroreductase
ACPL_RS22920	COG2267	carboxylic ester hydrolase activity
ACPL_RS22965	COG2814	Major facilitator Superfamily
ACPL_RS22970	COG2011	ABC-type metal ion transport system permease component
ACPL_RS22975	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACPL_RS23010	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACPL_RS23020	COG1695	Transcriptional regulator
ACPL_RS23045	COG1064	alcohol dehydrogenase
ACPL_RS23090	COG1476	TRANSCRIPTIONal
ACPL_RS23100	COG3903	Transcriptional regulator
ACPL_RS23100	COG3629	intracellular signal transduction
ACPL_RS23140	COG2357	RelA SpoT domain protein
ACPL_RS23170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_RS23190	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS23215	COG3850	Histidine kinase
ACPL_RS23215	COG3437	response regulator, receiver
ACPL_RS23215	COG2205	protein histidine kinase activity
ACPL_RS23215	COG4999	Histidine kinase
ACPL_RS23220	COG4251	negative regulation of phosphorylation
ACPL_RS23245	COG0745	RESPONSE REGULATOR receiver
ACPL_RS23260	COG2205	protein histidine kinase activity
ACPL_RS23260	COG0784	Response regulator, receiver
ACPL_RS23260	COG5002	protein histidine kinase activity
ACPL_RS23275	COG5001	Diguanylate cyclase
ACPL_RS23310	COG0300	oxidoreductase activity
ACPL_RS23320	COG0667	Aldo Keto reductase
ACPL_RS23385	COG1691	(AIR) carboxylase
ACPL_RS23390	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ACPL_RS23430	COG0477	Major facilitator Superfamily
ACPL_RS23450	COG2226	methyltransferase
ACPL_RS23470	COG5002	protein histidine kinase activity
ACPL_RS23580	COG4762	Protein conserved in bacteria
ACPL_RS23660	COG0477	Major facilitator Superfamily
ACPL_RS23725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACPL_RS23750	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACPL_RS23765	COG3239	Fatty acid desaturase
ACPL_RS23780	COG1376	ErfK ybiS ycfS ynhG family protein
ACPL_RS23795	COG1595	DNA-templated transcription, initiation
ACPL_RS23885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACPL_RS23915	COG3693	PFAM glycoside hydrolase, family 10
ACPL_RS23930	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACPL_RS23930	COG2755	lipolytic protein G-D-S-L family
ACPL_RS23950	COG0840	transmembrane signaling receptor activity
ACPL_RS23980	COG0583	DNA-binding transcription factor activity
ACPL_RS24080	COG0393	Putative heavy-metal-binding
ACPL_RS24085	COG0393	Putative heavy-metal-binding
ACPL_RS24195	COG2801	Transposase and inactivated derivatives
ACPL_RS24195	COG3415	Transposase
ACPL_RS24320	COG0515	serine threonine protein kinase
ACPL_RS24325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACPL_RS24330	COG0697	spore germination
ACPL_RS24335	COG1686	Belongs to the peptidase S11 family
ACPL_RS24375	COG1335	isochorismatase
ACPL_RS24405	COG0714	Associated with various cellular activities
ACPL_RS24445	COG0714	Associated with various cellular activities
ACPL_RS24450	COG3552	Protein containing von Willebrand factor type A (VWA) domain
ACPL_RS24500	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACPL_RS24520	COG0745	RESPONSE REGULATOR receiver
ACPL_RS24525	COG2205	protein histidine kinase activity
ACPL_RS24550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACPL_RS24570	COG1716	ATPase activity
ACPL_RS24575	COG0509	glycine decarboxylation via glycine cleavage system
ACPL_RS24620	COG0640	Transcriptional regulator
ACPL_RS24630	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
ACPL_RS24635	COG0384	phenazine biosynthesis protein PhzF
ACPL_RS24640	COG3447	MASE1 domain protein
ACPL_RS24640	COG5002	protein histidine kinase activity
ACPL_RS24640	COG5001	Diguanylate cyclase
ACPL_RS24645	COG0488	(ABC) transporter
ACPL_RS24665	COG1649	PFAM Uncharacterised BCR, COG1649
ACPL_RS24670	COG0297	glycogen (starch) synthase activity
ACPL_RS24675	COG5001	Diguanylate cyclase
ACPL_RS24680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ACPL_RS24705	COG2816	NAD+ diphosphatase activity
ACPL_RS24750	COG2501	S4 domain
ACPL_RS24765	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ACPL_RS24770	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPL_RS24775	COG1940	carbohydrate kinase activity
ACPL_RS24790	COG4214	carbohydrate transport
ACPL_RS24795	COG1129	ABC transporter
ACPL_RS24805	COG2160	L-arabinose isomerase activity
ACPL_RS24810	COG1609	Transcriptional regulator
ACPL_RS24845	COG3706	GGDEF domain
ACPL_RS24850	COG5006	permease, DMT superfamily
ACPL_RS24855	COG0577	efflux transmembrane transporter activity
ACPL_RS24855	COG1136	(ABC) transporter
ACPL_RS24860	COG0577	efflux transmembrane transporter activity
ACPL_RS24860	COG1136	(ABC) transporter
ACPL_RS24890	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACPL_RS24900	COG0840	transmembrane signaling receptor activity
ACPL_RS24905	COG2198	Histidine kinase
ACPL_RS24905	COG0643	Histidine kinase
ACPL_RS24910	COG2201	protein-glutamate methylesterase activity
ACPL_RS24920	COG0577	efflux transmembrane transporter activity
ACPL_RS24920	COG1136	(ABC) transporter
ACPL_RS24925	COG0577	efflux transmembrane transporter activity
ACPL_RS24925	COG1136	(ABC) transporter
ACPL_RS24935	COG2197	response regulator
ACPL_RS24965	COG1086	Polysaccharide biosynthesis protein
ACPL_RS24995	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ACPL_RS25005	COG2154	pterin-4-alpha-carbinolamine dehydratase
ACPL_RS25020	COG3119	arylsulfatase activity
ACPL_RS25030	COG0671	phosphoesterase, PA-phosphatase related
ACPL_RS25035	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ACPL_RS25050	COG1960	acyl-CoA dehydrogenase activity
ACPL_RS25055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACPL_RS25070	COG2226	methyltransferase
ACPL_RS25120	COG1309	transcriptional regulator
ACPL_RS25135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACPL_RS25140	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACPL_RS25145	COG1120	ATPase activity
ACPL_RS25155	COG0579	oxidoreductase
ACPL_RS25160	COG2205	protein histidine kinase activity
ACPL_RS25165	COG0745	RESPONSE REGULATOR receiver
ACPL_RS25170	COG1053	succinate dehydrogenase
ACPL_RS25170	COG3976	FMN-binding domain protein
ACPL_RS25170	COG0431	NADPH-dependent FMN reductase
ACPL_RS25175	COG1017	nitric oxide dioxygenase activity
ACPL_RS25175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACPL_RS25185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACPL_RS25215	COG2771	luxR family
ACPL_RS25215	COG2200	EAL domain
ACPL_RS25220	COG0318	PFAM AMP-dependent synthetase and ligase
ACPL_RS25230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACPL_RS25275	COG1022	Amp-dependent synthetase and ligase
ACPL_RS25290	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ACPL_RS25305	COG4581	dead DEAH box helicase
ACPL_RS25310	COG0546	phosphoglycolate phosphatase activity
ACPL_RS25330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACPL_RS25340	COG2378	regulation of single-species biofilm formation
ACPL_RS25350	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ACPL_RS25405	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ACPL_RS25410	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ACPL_RS25415	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ACPL_RS25425	COG4122	O-methyltransferase activity
ACPL_RS25435	COG1222	aaa ATPase
ACPL_RS25455	COG0517	IMP dehydrogenase activity
ACPL_RS25455	COG1994	Peptidase M50
ACPL_RS25465	COG2197	response regulator
ACPL_RS25470	COG0546	phosphoglycolate phosphatase activity
ACPL_RS25475	COG0577	efflux transmembrane transporter activity
ACPL_RS25475	COG1136	(ABC) transporter
ACPL_RS25480	COG1136	(ABC) transporter
ACPL_RS25480	COG0577	efflux transmembrane transporter activity
ACPL_RS25520	COG2197	response regulator
ACPL_RS25530	COG0215	cysteine-tRNA ligase activity
ACPL_RS25550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_RS25555	COG0667	Aldo Keto reductase
ACPL_RS25560	COG4585	Histidine kinase
ACPL_RS25580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACPL_RS25610	COG0542	response to heat
ACPL_RS25650	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ACPL_RS25660	COG0745	RESPONSE REGULATOR receiver
ACPL_RS25665	COG0653	protein targeting
ACPL_RS25695	COG1797	cobyrinic acid a,c-diamide synthase activity
ACPL_RS25720	COG0640	Transcriptional regulator
ACPL_RS25735	COG5001	Diguanylate cyclase
ACPL_RS25745	COG0708	Exodeoxyribonuclease III
ACPL_RS25775	COG1643	Atp-dependent helicase
ACPL_RS25785	COG0745	RESPONSE REGULATOR receiver
ACPL_RS25790	COG4251	negative regulation of phosphorylation
ACPL_RS25845	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ACPL_RS25855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACPL_RS25865	COG2183	response to ionizing radiation
ACPL_RS25915	COG5297	Belongs to the glycosyl hydrolase family 6
ACPL_RS25920	COG1595	DNA-templated transcription, initiation
ACPL_RS25930	COG5001	Diguanylate cyclase
ACPL_RS25940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACPL_RS25955	COG2197	response regulator
ACPL_RS25960	COG4585	Histidine kinase
ACPL_RS25965	COG0584	glycerophosphoryl diester phosphodiesterase
ACPL_RS26000	COG3447	MASE1 domain protein
ACPL_RS26000	COG5001	Diguanylate cyclase
ACPL_RS26000	COG5002	protein histidine kinase activity
ACPL_RS26030	COG1609	Transcriptional regulator
ACPL_RS26070	COG3866	Pectate lyase
ACPL_RS26080	COG0673	inositol 2-dehydrogenase activity
ACPL_RS26085	COG0246	Mannitol dehydrogenase
ACPL_RS26090	COG1904	glucuronate isomerase
ACPL_RS26095	COG0673	inositol 2-dehydrogenase activity
ACPL_RS26100	COG1609	Transcriptional regulator
ACPL_RS26110	COG1175	transmembrane transport
ACPL_RS26115	COG0395	ABC-type sugar transport system, permease component
ACPL_RS26130	COG0686	Belongs to the AlaDH PNT family
ACPL_RS26150	COG2197	response regulator
ACPL_RS26185	COG0596	Alpha beta hydrolase
ACPL_RS26185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACPL_RS26205	COG1486	melibiose metabolic process
ACPL_RS26210	COG1653	transport
ACPL_RS26225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACPL_RS26270	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ACPL_RS26280	COG1595	DNA-templated transcription, initiation
ACPL_RS26320	COG1653	transport
ACPL_RS26325	COG0395	ABC-type sugar transport system, permease component
ACPL_RS26330	COG0395	ABC-type sugar transport system, permease component
ACPL_RS26360	COG2409	Drug exporters of the RND superfamily
ACPL_RS26400	COG2160	L-arabinose isomerase activity
ACPL_RS26405	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACPL_RS26410	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACPL_RS26420	COG1879	ABC-type sugar transport system periplasmic component
ACPL_RS26425	COG1609	Transcriptional regulator
ACPL_RS26435	COG0235	Class ii aldolase
ACPL_RS26455	COG2130	NADP-dependent
ACPL_RS26460	COG1309	transcriptional regulator
ACPL_RS26465	COG0569	domain protein
ACPL_RS26480	COG4251	negative regulation of phosphorylation
ACPL_RS26490	COG0840	transmembrane signaling receptor activity
ACPL_RS26505	COG1131	(ABC) transporter
ACPL_RS26565	COG0583	DNA-binding transcription factor activity
ACPL_RS26570	COG1012	belongs to the aldehyde dehydrogenase family
ACPL_RS26585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACPL_RS26590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACPL_RS26615	COG3458	cephalosporin-C deacetylase activity
ACPL_RS26620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACPL_RS26635	COG0840	transmembrane signaling receptor activity
ACPL_RS26640	COG1461	Dihydroxyacetone kinase
ACPL_RS26645	COG2376	Dihydroxyacetone kinase
ACPL_RS26650	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ACPL_RS26650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACPL_RS26650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACPL_RS26675	COG4682	membrane
ACPL_RS26685	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS26710	COG1309	transcriptional regulator
ACPL_RS26730	COG0318	PFAM AMP-dependent synthetase and ligase
ACPL_RS26735	COG1960	acyl-CoA dehydrogenase activity
ACPL_RS26755	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ACPL_RS26755	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ACPL_RS26765	COG1476	TRANSCRIPTIONal
ACPL_RS26770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACPL_RS26780	COG1024	Enoyl-CoA hydratase
ACPL_RS26790	COG3940	Belongs to the glycosyl hydrolase 43 family
ACPL_RS26795	COG2200	EAL domain
ACPL_RS26795	COG2199	diguanylate cyclase activity
ACPL_RS26795	COG2202	Pas domain
ACPL_RS26810	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACPL_RS26815	COG2072	flavoprotein involved in K transport
ACPL_RS26825	COG0596	Alpha beta hydrolase
ACPL_RS26840	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACPL_RS26855	COG0477	Major facilitator Superfamily
ACPL_RS26860	COG1309	transcriptional regulator
ACPL_RS26875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACPL_RS26890	COG3206	protein involved in exopolysaccharide biosynthesis
ACPL_RS26890	COG0489	protein tyrosine kinase activity
ACPL_RS26910	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACPL_RS26915	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACPL_RS26935	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACPL_RS26965	COG1252	NADH dehydrogenase
ACPL_RS26970	COG1435	thymidine kinase activity
ACPL_RS26980	COG1132	(ABC) transporter
ACPL_RS26985	COG1132	(ABC) transporter
ACPL_RS27005	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ACPL_RS27010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACPL_RS27030	COG3548	integral membrane protein
ACPL_RS27070	COG3706	GGDEF domain
ACPL_RS27100	COG0395	ABC-type sugar transport system, permease component
ACPL_RS27110	COG1609	Transcriptional regulator
ACPL_RS27125	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
ACPL_RS27155	COG0300	oxidoreductase activity
ACPL_RS27175	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACPL_RS27225	COG0601	transmembrane transport
ACPL_RS27230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACPL_RS27270	COG1053	succinate dehydrogenase
ACPL_RS27270	COG3976	FMN-binding domain protein
ACPL_RS27285	COG2755	lipolytic protein G-D-S-L family
ACPL_RS27295	COG2226	methyltransferase
ACPL_RS27305	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACPL_RS27315	COG1414	Transcriptional regulator
ACPL_RS27320	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACPL_RS27355	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACPL_RS27360	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS27365	COG0489	protein tyrosine kinase activity
ACPL_RS27365	COG3206	protein involved in exopolysaccharide biosynthesis
ACPL_RS27445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACPL_RS27455	COG1086	Polysaccharide biosynthesis protein
ACPL_RS27470	COG2197	response regulator
ACPL_RS27475	COG0477	Major facilitator Superfamily
ACPL_RS27485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACPL_RS27495	COG4585	Histidine kinase
ACPL_RS27500	COG2197	response regulator
ACPL_RS27605	COG3300	MHYT domain
ACPL_RS27605	COG5001	Diguanylate cyclase
ACPL_RS27630	COG3511	phospholipase C
ACPL_RS27665	COG1132	(ABC) transporter
ACPL_RS27670	COG1132	(ABC) transporter
ACPL_RS27685	COG0745	RESPONSE REGULATOR receiver
ACPL_RS27690	COG2205	protein histidine kinase activity
ACPL_RS27705	COG2197	response regulator
ACPL_RS27720	COG1132	(ABC) transporter
ACPL_RS27735	COG1309	transcriptional regulator
ACPL_RS27760	COG1506	peptidase
ACPL_RS27760	COG0823	Involved in the tonB-independent uptake of proteins
ACPL_RS27865	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS27875	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ACPL_RS27880	COG0318	PFAM AMP-dependent synthetase and ligase
ACPL_RS27925	COG1921	L-seryl-tRNASec selenium transferase activity
ACPL_RS27945	COG0709	Synthesizes selenophosphate from selenide and ATP
ACPL_RS27960	COG0437	4 iron, 4 sulfur cluster binding
ACPL_RS27965	COG3383	formate dehydrogenase (NAD+) activity
ACPL_RS27965	COG0243	molybdopterin cofactor binding
ACPL_RS27970	COG0243	molybdopterin cofactor binding
ACPL_RS28030	COG3104	oligopeptide transport
ACPL_RS28315	COG0305	Participates in initiation and elongation during chromosome replication
ACPL_RS28320	COG2801	Transposase and inactivated derivatives
ACPL_RS28320	COG3415	Transposase
ACPL_RS28325	COG0305	Participates in initiation and elongation during chromosome replication
ACPL_RS28375	COG2837	iron assimilation
ACPL_RS28810	COG0840	transmembrane signaling receptor activity
ACPL_RS28820	COG1902	pentaerythritol trinitrate reductase activity
ACPL_RS28955	COG0358	DNA primase activity
ACPL_RS29025	COG3293	Transposase
ACPL_RS29080	COG3328	transposase activity
ACPL_RS29300	COG2358	TRAP transporter, solute receptor (TAXI family
ACPL_RS29305	COG0642	Histidine kinase
ACPL_RS29310	COG0745	RESPONSE REGULATOR receiver
ACPL_RS29355	COG3547	Transposase (IS116 IS110 IS902 family)
ACPL_RS29360	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ACPL_RS29370	COG4974	Belongs to the 'phage' integrase family
ACPL_RS29375	COG3104	oligopeptide transport
ACPL_RS29405	COG3345	alpha-galactosidase
ACPL_RS29415	COG1609	Transcriptional regulator
ACPL_RS29425	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ACPL_RS29445	COG0535	radical SAM domain protein
ACPL_RS29470	COG3321	synthase
ACPL_RS29470	COG0604	alcohol dehydrogenase
ACPL_RS29475	COG0604	alcohol dehydrogenase
ACPL_RS29475	COG3321	synthase
ACPL_RS29480	COG3321	synthase
ACPL_RS29480	COG0604	alcohol dehydrogenase
ACPL_RS29490	COG3321	synthase
ACPL_RS29490	COG0604	alcohol dehydrogenase
ACPL_RS29510	COG0477	Major facilitator Superfamily
ACPL_RS29540	COG3328	transposase activity
ACPL_RS29570	COG3903	Transcriptional regulator
ACPL_RS29570	COG3629	intracellular signal transduction
ACPL_RS29590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACPL_RS29595	COG2267	carboxylic ester hydrolase activity
ACPL_RS29600	COG0604	alcohol dehydrogenase
ACPL_RS29600	COG3321	synthase
ACPL_RS29630	COG1509	lysine 2,3-aminomutase activity
ACPL_RS29660	COG3706	GGDEF domain
ACPL_RS29675	COG0395	ABC-type sugar transport system, permease component
ACPL_RS29680	COG1175	transmembrane transport
ACPL_RS29705	COG2814	Major facilitator Superfamily
ACPL_RS29710	COG1846	Transcriptional regulator
ACPL_RS29760	COG1309	transcriptional regulator
ACPL_RS29775	COG0463	Glycosyl transferase, family 2
ACPL_RS29830	COG0515	serine threonine protein kinase
ACPL_RS29865	COG0745	RESPONSE REGULATOR receiver
ACPL_RS29880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPL_RS29880	COG2226	methyltransferase
ACPL_RS29880	COG3433	isochorismatase activity
ACPL_RS29900	COG0596	Alpha beta hydrolase
ACPL_RS29940	COG0475	glutathione-regulated potassium exporter activity
ACPL_RS29955	COG3903	Transcriptional regulator
ACPL_RS29955	COG3629	intracellular signal transduction
ACPL_RS29965	COG1021	2,3-dihydroxybenzoate-AMP ligase
ACPL_RS29975	COG2226	methyltransferase
ACPL_RS29975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPL_RS29975	COG3433	isochorismatase activity
ACPL_RS29980	COG1132	(ABC) transporter
ACPL_RS29985	COG2375	cellular response to nickel ion
ACPL_RS29985	COG1132	(ABC) transporter
ACPL_RS30025	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS30030	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPL_RS30125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACPL_RS30140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPL_RS30145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPL_RS30150	COG4221	oxidoreductase activity
ACPL_RS30150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPL_RS30150	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS30150	COG3321	synthase
ACPL_RS30170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACPL_RS30185	COG1162	GTPase activity
ACPL_RS30190	COG0745	RESPONSE REGULATOR receiver
ACPL_RS30195	COG5001	Diguanylate cyclase
ACPL_RS30195	COG3300	MHYT domain
ACPL_RS30215	COG4585	Histidine kinase
ACPL_RS30220	COG2197	response regulator
ACPL_RS30360	COG0367	asparagine synthase
ACPL_RS30375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPL_RS30395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACPL_RS30400	COG0019	diaminopimelate decarboxylase activity
ACPL_RS30425	COG1940	carbohydrate kinase activity
ACPL_RS30575	COG2826	transposase and inactivated derivatives, IS30 family
ACPL_RS30580	COG2963	transposase activity
ACPL_RS30700	COG1160	GTP binding
ACPL_RS30705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ACPL_RS30715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACPL_RS30720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACPL_RS30730	COG0318	PFAM AMP-dependent synthetase and ligase
ACPL_RS30740	COG2267	carboxylic ester hydrolase activity
ACPL_RS30750	COG1187	pseudouridine synthase activity
ACPL_RS30755	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ACPL_RS30760	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ACPL_RS30800	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS30820	COG0686	Belongs to the AlaDH PNT family
ACPL_RS30840	COG0702	epimerase
ACPL_RS30845	COG1733	regulation of RNA biosynthetic process
ACPL_RS30870	COG0494	nUDIX hydrolase
ACPL_RS30875	COG0504	CTP synthase activity
ACPL_RS30915	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACPL_RS30950	COG0647	UMP catabolic process
ACPL_RS30980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACPL_RS30985	COG2326	polyphosphate kinase activity
ACPL_RS30995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACPL_RS31000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACPL_RS31005	COG1063	alcohol dehydrogenase
ACPL_RS31010	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACPL_RS31010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACPL_RS31015	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACPL_RS31015	COG2213	PTS system mannitol-specific
ACPL_RS31020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACPL_RS31020	COG2213	PTS system mannitol-specific
ACPL_RS31040	COG0477	Major facilitator Superfamily
ACPL_RS31045	COG0563	adenylate kinase activity
ACPL_RS31060	COG0010	Belongs to the arginase family
ACPL_RS31070	COG2340	Cysteine-rich secretory protein family
ACPL_RS31095	COG2094	Belongs to the DNA glycosylase MPG family
ACPL_RS31100	COG3973	AAA domain
ACPL_RS31105	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACPL_RS31140	COG0730	response to heat
ACPL_RS31155	COG3833	ABC-type maltose transport systems, permease component
ACPL_RS31170	COG1609	Transcriptional regulator
ACPL_RS31175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACPL_RS31180	COG0165	Argininosuccinate lyase
ACPL_RS31210	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACPL_RS31215	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ACPL_RS31220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACPL_RS31225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACPL_RS31270	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ACPL_RS31280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACPL_RS31290	COG1472	Belongs to the glycosyl hydrolase 3 family
ACPL_RS31310	COG2949	membrane
ACPL_RS31315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACPL_RS31350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACPL_RS31350	COG0072	phenylalanine-tRNA ligase activity
ACPL_RS31355	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACPL_RS31360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACPL_RS31365	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACPL_RS31370	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACPL_RS31375	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACPL_RS31385	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACPL_RS31390	COG0140	phosphoribosyl-ATP diphosphatase activity
ACPL_RS31400	COG0765	amino acid transport
ACPL_RS31410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACPL_RS31415	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACPL_RS31415	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACPL_RS31445	COG0745	RESPONSE REGULATOR receiver
ACPL_RS31460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACPL_RS31465	COG0242	peptide deformylase activity
ACPL_RS31475	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACPL_RS31485	COG1758	RNA polymerase activity
ACPL_RS31490	COG0194	GDP metabolic process
ACPL_RS31500	COG0284	orotidine-5'-phosphate decarboxylase activity
ACPL_RS31505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACPL_RS31510	COG0167	dihydroorotate dehydrogenase activity
ACPL_RS31520	COG0505	Belongs to the CarA family
ACPL_RS31525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACPL_RS31530	COG0540	Belongs to the ATCase OTCase family
ACPL_RS31535	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ACPL_RS31545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACPL_RS31550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACPL_RS31555	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ACPL_RS31560	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACPL_RS31565	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACPL_RS31570	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACPL_RS31580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACPL_RS31590	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ACPL_RS31595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACPL_RS31640	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACPL_RS31695	COG3964	amidohydrolase
ACPL_RS31700	COG0251	oxidation-reduction process
ACPL_RS31705	COG0515	serine threonine protein kinase
ACPL_RS31710	COG0831	urea catabolic process
ACPL_RS31715	COG0832	Belongs to the urease beta subunit family
ACPL_RS31740	COG0515	serine threonine protein kinase
ACPL_RS31745	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACPL_RS31745	COG0189	ligase activity
ACPL_RS31750	COG4242	Belongs to the peptidase S51 family
ACPL_RS31765	COG0124	histidyl-tRNA synthetase
ACPL_RS31785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACPL_RS31790	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACPL_RS31805	COG1862	Preprotein translocase
ACPL_RS31810	COG2255	four-way junction helicase activity
ACPL_RS31815	COG0632	four-way junction helicase activity
ACPL_RS31820	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ACPL_RS31845	COG0217	transcriptional regulatory protein
ACPL_RS31850	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ACPL_RS31855	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ACPL_RS31865	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS31870	COG1560	Kdo2-lipid A biosynthetic process
ACPL_RS31900	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACPL_RS31915	COG2205	protein histidine kinase activity
ACPL_RS31925	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACPL_RS31930	COG4106	trans-aconitate 2-methyltransferase activity
ACPL_RS31935	COG0667	Aldo Keto reductase
ACPL_RS31945	COG1278	Cold shock
ACPL_RS31980	COG1472	Belongs to the glycosyl hydrolase 3 family
ACPL_RS31985	COG0514	ATP-dependent DNA helicase (RecQ)
ACPL_RS32025	COG4585	Histidine kinase
ACPL_RS32040	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS32115	COG0305	Participates in initiation and elongation during chromosome replication
ACPL_RS32125	COG0483	inositol monophosphate 1-phosphatase activity
ACPL_RS32135	COG0542	response to heat
ACPL_RS32145	COG2309	aminopeptidase activity
ACPL_RS32165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ACPL_RS32180	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ACPL_RS32185	COG2351	hydroxyisourate hydrolase activity
ACPL_RS32190	COG1643	Atp-dependent helicase
ACPL_RS32195	COG2226	methyltransferase
ACPL_RS32220	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACPL_RS32300	COG5002	protein histidine kinase activity
ACPL_RS32310	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ACPL_RS32315	COG0823	Involved in the tonB-independent uptake of proteins
ACPL_RS32320	COG0405	Gamma-glutamyltransferase
ACPL_RS32340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACPL_RS32355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACPL_RS32360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_RS32370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_RS32410	COG1686	Belongs to the peptidase S11 family
ACPL_RS32420	COG1191	sigma factor activity
ACPL_RS32425	COG2226	methyltransferase
ACPL_RS32430	COG3973	AAA domain
ACPL_RS32440	COG1191	sigma factor activity
ACPL_RS32445	COG0513	Belongs to the DEAD box helicase family
ACPL_RS32475	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACPL_RS32480	COG1609	Transcriptional regulator
ACPL_RS32490	COG4608	Belongs to the ABC transporter superfamily
ACPL_RS32495	COG0601	transmembrane transport
ACPL_RS32500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACPL_RS32505	COG0444	Belongs to the ABC transporter superfamily
ACPL_RS32540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ACPL_RS32545	COG0187	DNA topoisomerase II activity
ACPL_RS32555	COG2197	response regulator
ACPL_RS32565	COG2205	protein histidine kinase activity
ACPL_RS32570	COG0745	RESPONSE REGULATOR receiver
ACPL_RS32580	COG1846	Transcriptional regulator
ACPL_RS32585	COG0697	spore germination
ACPL_RS32595	COG0714	Associated with various cellular activities
ACPL_RS32605	COG3552	Protein containing von Willebrand factor type A (VWA) domain
ACPL_RS32680	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACPL_RS32710	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACPL_RS32715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACPL_RS32715	COG1017	nitric oxide dioxygenase activity
ACPL_RS32735	COG0395	ABC-type sugar transport system, permease component
ACPL_RS32755	COG2197	response regulator
ACPL_RS32770	COG0577	efflux transmembrane transporter activity
ACPL_RS32770	COG1136	(ABC) transporter
ACPL_RS32780	COG2755	lipolytic protein G-D-S-L family
ACPL_RS32810	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACPL_RS32815	COG1136	(ABC) transporter
ACPL_RS32830	COG0598	Magnesium transport protein CorA
ACPL_RS32835	COG3201	nicotinamide mononucleotide transporter
ACPL_RS32840	COG3135	benzoate transporter
ACPL_RS32865	COG0436	Aminotransferase
ACPL_RS32900	COG1673	EVE domain
ACPL_RS32930	COG3509	depolymerase
ACPL_RS32945	COG1136	(ABC) transporter
ACPL_RS32945	COG0577	efflux transmembrane transporter activity
ACPL_RS32955	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ACPL_RS33055	COG2318	DinB family
ACPL_RS33085	COG0671	phosphoesterase, PA-phosphatase related
ACPL_RS33095	COG1803	Methylglyoxal synthase
ACPL_RS33095	COG1597	lipid kinase activity
ACPL_RS33130	COG0745	RESPONSE REGULATOR receiver
ACPL_RS33170	COG2197	response regulator
ACPL_RS33175	COG4585	Histidine kinase
ACPL_RS33200	COG1335	isochorismatase
ACPL_RS33210	COG0789	Transcriptional regulator
ACPL_RS33225	COG0800	Aldolase
ACPL_RS33255	COG0366	Alpha amylase catalytic
ACPL_RS33260	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS33265	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS33290	COG0673	inositol 2-dehydrogenase activity
ACPL_RS33305	COG3483	tryptophan 2,3-dioxygenase activity
ACPL_RS33310	COG3012	SEC-C Motif Domain Protein
ACPL_RS33315	COG0840	transmembrane signaling receptor activity
ACPL_RS33335	COG0366	Alpha amylase catalytic
ACPL_RS33345	COG1175	transmembrane transport
ACPL_RS33350	COG1653	transport
ACPL_RS33360	COG0659	secondary active sulfate transmembrane transporter activity
ACPL_RS33370	COG2308	Evidence 4 Homologs of previously reported genes of
ACPL_RS33370	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACPL_RS33375	COG0367	asparagine synthase
ACPL_RS33410	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ACPL_RS33430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACPL_RS33485	COG2197	response regulator
ACPL_RS33490	COG4585	Histidine kinase
ACPL_RS33510	COG1131	(ABC) transporter
ACPL_RS33515	COG0328	RNA-DNA hybrid ribonuclease activity
ACPL_RS33560	COG1653	transport
ACPL_RS33565	COG3285	dna ligase
ACPL_RS33565	COG1793	dna ligase
ACPL_RS33575	COG4585	Histidine kinase
ACPL_RS33580	COG2197	response regulator
ACPL_RS33585	COG5001	Diguanylate cyclase
ACPL_RS33600	COG0071	Belongs to the small heat shock protein (HSP20) family
ACPL_RS33605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACPL_RS33610	COG1278	Cold shock
ACPL_RS33630	COG1595	DNA-templated transcription, initiation
ACPL_RS33645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACPL_RS33665	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS33670	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS33690	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS33695	COG1216	Glycosyl transferase, family 2
ACPL_RS33715	COG2807	transmembrane transport
ACPL_RS33730	COG4249	Peptidase C14 caspase catalytic subunit p20
ACPL_RS33730	COG2319	Wd-40 repeat
ACPL_RS33750	COG0058	SHG alpha-glucan phosphorylase activity
ACPL_RS33770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACPL_RS33795	COG1960	acyl-CoA dehydrogenase activity
ACPL_RS33895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACPL_RS33900	COG0714	Associated with various cellular activities
ACPL_RS33915	COG2304	oxidoreductase activity
ACPL_RS33960	COG1132	(ABC) transporter
ACPL_RS33985	COG4260	virion core protein, lumpy skin disease virus
ACPL_RS34030	COG2378	regulation of single-species biofilm formation
ACPL_RS34110	COG0543	2 iron, 2 sulfur cluster binding
ACPL_RS34110	COG0633	Ferredoxin
ACPL_RS34130	COG5001	Diguanylate cyclase
ACPL_RS34130	COG3300	MHYT domain
ACPL_RS34150	COG3486	L-lysine 6-monooxygenase (NADPH) activity
ACPL_RS34200	COG1470	cell adhesion involved in biofilm formation
ACPL_RS34200	COG0366	Alpha amylase catalytic
ACPL_RS34225	COG1609	Transcriptional regulator
ACPL_RS34240	COG1960	acyl-CoA dehydrogenase activity
ACPL_RS34245	COG5001	Diguanylate cyclase
ACPL_RS34260	COG2197	response regulator
ACPL_RS34285	COG2409	Drug exporters of the RND superfamily
ACPL_RS34325	COG2264	protein methyltransferase activity
ACPL_RS34340	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACPL_RS34345	COG0156	8-amino-7-oxononanoate synthase activity
ACPL_RS34350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACPL_RS34380	COG0420	3'-5' exonuclease activity
ACPL_RS34385	COG0419	ATPase involved in DNA repair
ACPL_RS34450	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ACPL_RS34490	COG1793	dna ligase
ACPL_RS34525	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACPL_RS34535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ACPL_RS34540	COG0655	NAD(P)H dehydrogenase (quinone) activity
ACPL_RS34555	COG3253	May function as heme-dependent peroxidase
ACPL_RS34560	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ACPL_RS34565	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACPL_RS34575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACPL_RS34580	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ACPL_RS34585	COG0183	Belongs to the thiolase family
ACPL_RS34590	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACPL_RS34590	COG1024	Enoyl-CoA hydratase
ACPL_RS34600	COG2205	protein histidine kinase activity
ACPL_RS34605	COG0745	RESPONSE REGULATOR receiver
ACPL_RS34620	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACPL_RS34625	COG1301	dicarboxylic acid transport
ACPL_RS34630	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACPL_RS34635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACPL_RS34640	COG0531	amino acid
ACPL_RS34645	COG0569	domain protein
ACPL_RS34670	COG0756	dUTP diphosphatase activity
ACPL_RS34710	COG5001	Diguanylate cyclase
ACPL_RS34710	COG3447	MASE1 domain protein
ACPL_RS34710	COG5002	protein histidine kinase activity
ACPL_RS34720	COG2860	membrane
ACPL_RS34730	COG2313	pseudouridylate synthase activity
ACPL_RS34765	COG0745	RESPONSE REGULATOR receiver
ACPL_RS34775	COG0643	Histidine kinase
ACPL_RS34775	COG2198	Histidine kinase
ACPL_RS34775	COG0784	Response regulator, receiver
ACPL_RS34775	COG2198	Histidine kinase
ACPL_RS34775	COG0643	Histidine kinase
ACPL_RS34775	COG0784	Response regulator, receiver
ACPL_RS34785	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACPL_RS34795	COG2201	protein-glutamate methylesterase activity
ACPL_RS34800	COG0835	chemotaxis
ACPL_RS34815	COG1490	D-aminoacyl-tRNA deacylase activity
ACPL_RS34835	COG0123	including yeast histone deacetylase and acetoin utilization protein
ACPL_RS34860	COG0738	Major facilitator superfamily
ACPL_RS34870	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACPL_RS34875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACPL_RS34880	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACPL_RS34890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ACPL_RS34900	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACPL_RS34905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACPL_RS34910	COG1196	nuclear chromosome segregation
ACPL_RS34925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACPL_RS34945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACPL_RS34955	COG1126	abc transporter atp-binding protein
ACPL_RS34960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACPL_RS34965	COG0765	amino acid transport
ACPL_RS34970	COG0765	amino acid transport
ACPL_RS34975	COG1418	mRNA catabolic process
ACPL_RS34980	COG2137	regulation of response to DNA damage stimulus
ACPL_RS34985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACPL_RS34995	COG1573	uracil-dna glycosylase
ACPL_RS35015	COG2815	serine threonine protein kinase
ACPL_RS35015	COG0515	serine threonine protein kinase
ACPL_RS35020	COG1201	RNA secondary structure unwinding
ACPL_RS35035	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACPL_RS35045	COG1842	Phage shock protein A
ACPL_RS35050	COG1396	sequence-specific DNA binding
ACPL_RS35055	COG1058	Belongs to the CinA family
ACPL_RS35055	COG1546	Belongs to the CinA family
ACPL_RS35065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACPL_RS35080	COG1674	ftsk spoiiie
ACPL_RS35095	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ACPL_RS35100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACPL_RS35110	COG3214	Protein conserved in bacteria
ACPL_RS35115	COG0456	acetyltransferase
ACPL_RS35125	COG1278	Cold shock
ACPL_RS35135	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ACPL_RS35140	COG0612	Peptidase, M16
ACPL_RS35145	COG1185	polyribonucleotide nucleotidyltransferase activity
ACPL_RS35150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACPL_RS35165	COG0745	RESPONSE REGULATOR receiver
ACPL_RS35170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACPL_RS35180	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ACPL_RS35185	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACPL_RS35200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACPL_RS35220	COG0779	Required for maturation of 30S ribosomal subunits
ACPL_RS35260	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ACPL_RS35265	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ACPL_RS35275	COG1012	belongs to the aldehyde dehydrogenase family
ACPL_RS35295	COG1668	transmembrane transport
ACPL_RS35300	COG4152	abc transporter atp-binding protein
ACPL_RS35305	COG2197	response regulator
ACPL_RS35310	COG4585	Histidine kinase
ACPL_RS35330	COG1511	domain protein
ACPL_RS35340	COG3845	ABC transporter
ACPL_RS35350	COG0640	Transcriptional regulator
ACPL_RS35365	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACPL_RS35370	COG0750	zinc metalloprotease
ACPL_RS35395	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACPL_RS35395	COG2146	nitrite reductase [NAD(P)H] activity
ACPL_RS35410	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACPL_RS35420	COG0233	cytoplasmic translational termination
ACPL_RS35425	COG0528	UMP kinase activity
ACPL_RS35430	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACPL_RS35435	COG0052	Belongs to the universal ribosomal protein uS2 family
ACPL_RS35440	COG0792	nuclease activity
ACPL_RS35470	COG2188	Transcriptional regulator
ACPL_RS35495	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACPL_RS35500	COG0494	nUDIX hydrolase
ACPL_RS35505	COG0681	Belongs to the peptidase S26 family
ACPL_RS35510	COG0681	Belongs to the peptidase S26 family
ACPL_RS35515	COG0335	large ribosomal subunit rRNA binding
ACPL_RS35520	COG0336	Belongs to the RNA methyltransferase TrmD family
ACPL_RS35525	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACPL_RS35530	COG1837	Belongs to the UPF0109 family
ACPL_RS35535	COG0228	four-way junction DNA binding
ACPL_RS35545	COG0442	prolyl-tRNA aminoacylation
ACPL_RS35580	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS35595	COG0463	Glycosyl transferase, family 2
ACPL_RS35605	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACPL_RS35605	COG2755	lipolytic protein G-D-S-L family
ACPL_RS35620	COG1215	transferase activity, transferring glycosyl groups
ACPL_RS35635	COG1216	Glycosyl transferase, family 2
ACPL_RS35640	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ACPL_RS35670	COG2318	DinB family
ACPL_RS35695	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS35710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACPL_RS35720	COG0571	ribonuclease III activity
ACPL_RS35730	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACPL_RS35745	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACPL_RS35750	COG0742	ribosomal rna small subunit methyltransferase
ACPL_RS35770	COG1461	Dihydroxyacetone kinase
ACPL_RS35775	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACPL_RS35780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACPL_RS35800	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACPL_RS35815	COG0626	cystathionine gamma-synthase activity
ACPL_RS35820	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACPL_RS35830	COG1920	GTP binding
ACPL_RS35840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ACPL_RS35855	COG0776	regulation of translation
ACPL_RS35860	COG0066	3-isopropylmalate dehydratase activity
ACPL_RS35890	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACPL_RS35895	COG1476	TRANSCRIPTIONal
ACPL_RS35905	COG1131	(ABC) transporter
ACPL_RS35925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACPL_RS35950	COG0612	Peptidase, M16
ACPL_RS35955	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACPL_RS35970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACPL_RS35975	COG0473	3-isopropylmalate dehydrogenase activity
ACPL_RS35995	COG0440	acetolactate synthase activity
ACPL_RS36005	COG5001	Diguanylate cyclase
ACPL_RS36005	COG3300	MHYT domain
ACPL_RS36010	COG0129	dihydroxy-acid dehydratase activity
ACPL_RS36030	COG2132	Multicopper oxidase
ACPL_RS36050	COG1609	Transcriptional regulator
ACPL_RS36055	COG5001	Diguanylate cyclase
ACPL_RS36065	COG2133	pyrroloquinoline quinone binding
ACPL_RS36075	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACPL_RS36085	COG0154	amidase activity
ACPL_RS36090	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACPL_RS36100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACPL_RS36110	COG0482	sulfurtransferase activity
ACPL_RS36120	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ACPL_RS36125	COG2086	electron transfer activity
ACPL_RS36130	COG2149	membrane
ACPL_RS36150	COG1595	DNA-templated transcription, initiation
ACPL_RS36160	COG0443	Heat shock 70 kDa protein
ACPL_RS36180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACPL_RS36185	COG1119	ATPase activity
ACPL_RS36195	COG1472	Belongs to the glycosyl hydrolase 3 family
ACPL_RS36200	COG2902	Dehydrogenase
ACPL_RS36210	COG0010	Belongs to the arginase family
ACPL_RS36220	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACPL_RS36220	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACPL_RS36225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACPL_RS36235	COG1703	isobutyryl-CoA mutase activity
ACPL_RS36240	COG0183	Belongs to the thiolase family
ACPL_RS36260	COG3046	protein related to deoxyribodipyrimidine photolyase
ACPL_RS36275	COG4133	protoheme IX ABC transporter activity
ACPL_RS36305	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
ACPL_RS36320	COG1674	ftsk spoiiie
ACPL_RS36330	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACPL_RS36365	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACPL_RS36375	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACPL_RS36380	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACPL_RS36385	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACPL_RS36390	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACPL_RS36395	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ACPL_RS36400	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACPL_RS36405	COG0356	it plays a direct role in the translocation of protons across the membrane
ACPL_RS36420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACPL_RS36425	COG0702	epimerase
ACPL_RS36430	COG0251	oxidation-reduction process
ACPL_RS36440	COG0009	L-threonylcarbamoyladenylate synthase
ACPL_RS36455	COG2890	protein-(glutamine-N5) methyltransferase activity
ACPL_RS36475	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACPL_RS36480	COG0254	rRNA binding
ACPL_RS36500	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ACPL_RS36510	COG0083	homoserine kinase activity
ACPL_RS36520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACPL_RS36525	COG1846	Transcriptional regulator
ACPL_RS36530	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACPL_RS36540	COG0460	homoserine dehydrogenase
ACPL_RS36550	COG0018	arginyl-trna synthetase
ACPL_RS36570	COG0655	NAD(P)H dehydrogenase (quinone) activity
ACPL_RS36590	COG4166	transmembrane transport
ACPL_RS36595	COG3958	Transketolase
ACPL_RS36600	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ACPL_RS36605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACPL_RS36610	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACPL_RS36625	COG0189	ligase activity
ACPL_RS36655	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ACPL_RS36665	COG2815	serine threonine protein kinase
ACPL_RS36665	COG0515	serine threonine protein kinase
ACPL_RS36685	COG1733	regulation of RNA biosynthetic process
ACPL_RS36710	COG0673	inositol 2-dehydrogenase activity
ACPL_RS36730	COG0754	glutathionylspermidine amidase activity
ACPL_RS36760	COG3469	chitinase activity
ACPL_RS36775	COG0706	membrane insertase activity
ACPL_RS36785	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACPL_RS36800	COG0740	serine-type endopeptidase activity
ACPL_RS36810	COG1834	amidinotransferase
ACPL_RS36815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACPL_RS36850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACPL_RS36855	COG2205	protein histidine kinase activity
ACPL_RS36860	COG0745	RESPONSE REGULATOR receiver
ACPL_RS36880	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACPL_RS36880	COG0567	Dehydrogenase, E1 component
ACPL_RS36885	COG0857	belongs to the CobB CobQ family
ACPL_RS36885	COG0280	phosphate acetyltransferase
ACPL_RS36890	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACPL_RS36915	COG2172	sigma factor antagonist activity
ACPL_RS36920	COG2188	Transcriptional regulator
ACPL_RS36930	COG1597	lipid kinase activity
ACPL_RS36945	COG0175	sulfate reduction
ACPL_RS36960	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACPL_RS36970	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ACPL_RS36980	COG1595	DNA-templated transcription, initiation
ACPL_RS36995	COG2135	peptidase activity
ACPL_RS37000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACPL_RS37005	COG1162	GTPase activity
ACPL_RS37010	COG0483	inositol monophosphate 1-phosphatase activity
ACPL_RS37085	COG1357	PFAM Pentapeptide repeats (8 copies)
ACPL_RS37125	COG0477	Major facilitator Superfamily
ACPL_RS37130	COG3800	Transcriptional regulator
ACPL_RS37130	COG1396	sequence-specific DNA binding
ACPL_RS37145	COG1615	UPF0182 protein
ACPL_RS37150	COG3480	Lon protease (S16) C-terminal proteolytic domain
ACPL_RS37175	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACPL_RS37210	COG2816	NAD+ diphosphatase activity
ACPL_RS37225	COG1959	2 iron, 2 sulfur cluster binding
ACPL_RS37235	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ACPL_RS37255	COG1278	Cold shock
ACPL_RS37270	COG0210	DNA helicase
ACPL_RS37270	COG0210	DNA helicase
ACPL_RS37275	COG1611	Belongs to the LOG family
ACPL_RS37280	COG1611	Belongs to the LOG family
ACPL_RS37295	COG2171	N-acyltransferase activity
ACPL_RS37345	COG4221	oxidoreductase activity
ACPL_RS37370	COG0456	acetyltransferase
ACPL_RS37385	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACPL_RS37390	COG0823	Involved in the tonB-independent uptake of proteins
ACPL_RS37390	COG1506	peptidase
ACPL_RS37400	COG0312	modulator of DNA gyrase
ACPL_RS37410	COG1053	succinate dehydrogenase
ACPL_RS37470	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS37480	COG1960	acyl-CoA dehydrogenase activity
ACPL_RS37495	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ACPL_RS37510	COG0318	PFAM AMP-dependent synthetase and ligase
ACPL_RS37580	COG0012	GTP binding
ACPL_RS37595	COG2169	Transcriptional regulator
ACPL_RS37595	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACPL_RS37615	COG0525	valine-tRNA ligase activity
ACPL_RS37635	COG1322	Protein conserved in bacteria
ACPL_RS37640	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACPL_RS37650	COG1570	exodeoxyribonuclease VII activity
ACPL_RS37655	COG1722	exodeoxyribonuclease VII activity
ACPL_RS37685	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ACPL_RS37690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACPL_RS37690	COG0561	phosphatase activity
ACPL_RS37695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACPL_RS37700	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ACPL_RS37705	COG1595	DNA-templated transcription, initiation
ACPL_RS37735	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACPL_RS37765	COG0424	maF-like protein
ACPL_RS37770	COG4770	biotin carboxylase activity
ACPL_RS37820	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACPL_RS37820	COG1473	amidohydrolase
ACPL_RS37825	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACPL_RS37825	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACPL_RS37830	COG0515	serine threonine protein kinase
ACPL_RS37830	COG2815	serine threonine protein kinase
ACPL_RS37835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACPL_RS37850	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ACPL_RS37900	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ACPL_RS37910	COG1012	belongs to the aldehyde dehydrogenase family
ACPL_RS37915	COG1012	belongs to the aldehyde dehydrogenase family
ACPL_RS37945	COG2018	Roadblock/LC7 domain
ACPL_RS37955	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACPL_RS37980	COG1079	Belongs to the binding-protein-dependent transport system permease family
ACPL_RS37985	COG4603	Belongs to the binding-protein-dependent transport system permease family
ACPL_RS37990	COG3845	ABC transporter
ACPL_RS37995	COG1744	ABC transporter substrate-binding protein PnrA-like
ACPL_RS38020	COG0180	Tryptophanyl-tRNA synthetase
ACPL_RS38025	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACPL_RS38030	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ACPL_RS38055	COG1218	3'(2'),5'-bisphosphate nucleotidase
ACPL_RS38060	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACPL_RS38065	COG0193	aminoacyl-tRNA hydrolase activity
ACPL_RS38080	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACPL_RS38095	COG1309	transcriptional regulator
ACPL_RS38105	COG0488	(ABC) transporter
ACPL_RS38110	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACPL_RS38115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACPL_RS38120	COG0084	hydrolase, TatD family'
ACPL_RS38130	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACPL_RS38175	COG4974	Belongs to the 'phage' integrase family
ACPL_RS38195	COG0303	'Molybdopterin
ACPL_RS38200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ACPL_RS38255	COG2095	MarC family integral membrane protein
ACPL_RS38260	COG0613	PHP domain protein
ACPL_RS38280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACPL_RS38320	COG0384	phenazine biosynthesis protein PhzF
ACPL_RS38325	COG2239	Acts as a magnesium transporter
ACPL_RS38340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACPL_RS38345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACPL_RS38355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACPL_RS38365	COG1024	Enoyl-CoA hydratase
ACPL_RS38375	COG0519	Catalyzes the synthesis of GMP from XMP
ACPL_RS38390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPL_RS38395	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACPL_RS38395	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACPL_RS38400	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACPL_RS38405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACPL_RS38435	COG0113	porphobilinogen synthase activity
ACPL_RS38440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACPL_RS38440	COG1587	Uroporphyrinogen-III synthase
ACPL_RS38445	COG0181	hydroxymethylbilane synthase activity
ACPL_RS38450	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACPL_RS38455	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ACPL_RS38470	COG0318	PFAM AMP-dependent synthetase and ligase
ACPL_RS38475	COG1595	DNA-templated transcription, initiation
ACPL_RS38500	COG0506	proline dehydrogenase activity
ACPL_RS38510	COG1082	Xylose isomerase domain protein TIM barrel
ACPL_RS38535	COG0588	phosphoglycerate mutase activity
ACPL_RS38555	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS38570	COG0745	RESPONSE REGULATOR receiver
ACPL_RS38585	COG5002	protein histidine kinase activity
ACPL_RS38600	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ACPL_RS38605	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ACPL_RS38615	COG4786	Flagellar basal body rod
ACPL_RS38615	COG1256	bacterial-type flagellum assembly
ACPL_RS38635	COG1516	flagellar protein fliS
ACPL_RS38645	COG1815	bacterial-type flagellum-dependent cell motility
ACPL_RS38655	COG1677	Flagellar hook-basal body complex protein FliE
ACPL_RS38665	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACPL_RS38675	COG1157	protein secretion by the type III secretion system
ACPL_RS38685	COG1196	nuclear chromosome segregation
ACPL_RS38685	COG0739	heme binding
ACPL_RS38685	COG0741	lytic transglycosylase activity
ACPL_RS38705	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACPL_RS38710	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACPL_RS38720	COG1338	Plays a role in the flagellum-specific transport system
ACPL_RS38730	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACPL_RS38730	COG1776	CheC inhibitor of MCP methylation
ACPL_RS38735	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACPL_RS38745	COG1360	Flagellar Motor Protein
ACPL_RS38750	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ACPL_RS38775	COG0745	RESPONSE REGULATOR receiver
ACPL_RS38785	COG0745	RESPONSE REGULATOR receiver
ACPL_RS38795	COG2201	protein-glutamate methylesterase activity
ACPL_RS38810	COG2198	Histidine kinase
ACPL_RS38810	COG0784	Response regulator, receiver
ACPL_RS38810	COG0643	Histidine kinase
ACPL_RS38815	COG0745	RESPONSE REGULATOR receiver
ACPL_RS38820	COG2340	Cysteine-rich secretory protein family
ACPL_RS38825	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ACPL_RS38885	COG3246	L-lysine catabolic process to acetate
ACPL_RS38890	COG0354	folic acid binding
ACPL_RS38910	COG4044	May play a role in the intracellular transport of hydrophobic ligands
ACPL_RS38945	COG1595	DNA-templated transcription, initiation
ACPL_RS38975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACPL_RS38980	COG0581	inorganic phosphate transmembrane transporter activity
ACPL_RS38995	COG0456	acetyltransferase
ACPL_RS39000	COG0745	RESPONSE REGULATOR receiver
ACPL_RS39035	COG2339	peptidase activity
ACPL_RS39065	COG0459	protein refolding
ACPL_RS39080	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACPL_RS39090	COG1131	(ABC) transporter
ACPL_RS39095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACPL_RS39110	COG1131	(ABC) transporter
ACPL_RS39115	COG1349	DNA-binding transcription factor activity
ACPL_RS39125	COG1940	carbohydrate kinase activity
ACPL_RS39135	COG1131	(ABC) transporter
ACPL_RS39150	COG2197	response regulator
ACPL_RS39205	COG3842	ATPase activity
ACPL_RS39235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACPL_RS39240	COG0215	cysteine-tRNA ligase activity
ACPL_RS39245	COG1404	Belongs to the peptidase S8 family
ACPL_RS39250	COG0114	fumarate hydratase activity
ACPL_RS39255	COG3903	Transcriptional regulator
ACPL_RS39255	COG3629	intracellular signal transduction
ACPL_RS39265	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ACPL_RS39265	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ACPL_RS39280	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ACPL_RS39290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACPL_RS39300	COG1940	carbohydrate kinase activity
ACPL_RS39320	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACPL_RS39325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACPL_RS39350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACPL_RS39365	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ACPL_RS39370	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ACPL_RS39395	COG1194	a g-specific adenine glycosylase
ACPL_RS39430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACPL_RS39435	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ACPL_RS39445	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ACPL_RS39455	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ACPL_RS39460	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACPL_RS39475	COG0649	NAD binding
ACPL_RS39490	COG1174	glycine betaine transport
ACPL_RS39495	COG1174	glycine betaine transport
ACPL_RS39530	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ACPL_RS39555	COG1196	nuclear chromosome segregation
ACPL_RS39555	COG0741	lytic transglycosylase activity
ACPL_RS39555	COG0739	heme binding
ACPL_RS39565	COG1674	ftsk spoiiie
ACPL_RS39580	COG0302	gtp cyclohydrolase
ACPL_RS39585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACPL_RS39590	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ACPL_RS39595	COG0037	tRNA processing
ACPL_RS39605	COG2027	D-alanyl-D-alanine carboxypeptidase
ACPL_RS39610	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ACPL_RS39620	COG1674	ftsk spoiiie
ACPL_RS39640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACPL_RS39650	COG2843	Capsule synthesis protein
ACPL_RS39665	COG4770	biotin carboxylase activity
ACPL_RS39700	COG0003	Pfam Anion-transporting ATPase
ACPL_RS39710	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ACPL_RS39715	COG1610	YqeY-like protein
ACPL_RS39720	COG1408	metallophosphoesterase
ACPL_RS39735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACPL_RS39755	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACPL_RS39770	COG4608	Belongs to the ABC transporter superfamily
ACPL_RS39785	COG0747	negative chemotaxis
ACPL_RS39795	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACPL_RS39800	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACPL_RS39835	COG0813	purine-nucleoside phosphorylase activity
ACPL_RS39840	COG0590	tRNA wobble adenosine to inosine editing
ACPL_RS39865	COG0287	Prephenate dehydrogenase
ACPL_RS39870	COG2318	DinB family
ACPL_RS39875	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ACPL_RS39875	COG0235	Class ii aldolase
ACPL_RS39880	COG0501	Belongs to the peptidase M48B family
ACPL_RS39885	COG1796	DNA polymerase
ACPL_RS39885	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ACPL_RS39900	COG0642	Histidine kinase
ACPL_RS39905	COG2018	Roadblock/LC7 domain
ACPL_RS39955	COG3979	chitinase
ACPL_RS40015	COG0778	Nitroreductase
ACPL_RS40025	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ACPL_RS40045	COG2205	protein histidine kinase activity
ACPL_RS40065	COG1268	BioY protein
ACPL_RS40090	COG0667	Aldo Keto reductase
ACPL_RS40105	COG1131	(ABC) transporter
ACPL_RS40115	COG1595	DNA-templated transcription, initiation
ACPL_RS40135	COG0673	inositol 2-dehydrogenase activity
ACPL_RS40140	COG0243	molybdopterin cofactor binding
ACPL_RS40150	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ACPL_RS40160	COG1435	thymidine kinase activity
ACPL_RS40170	COG0443	Heat shock 70 kDa protein
ACPL_RS40200	COG2268	Band 7 protein
ACPL_RS40220	COG3979	chitinase
ACPL_RS40225	COG2199	diguanylate cyclase activity
ACPL_RS40225	COG2200	EAL domain
ACPL_RS40245	COG0148	phosphopyruvate hydratase activity
ACPL_RS40250	COG0789	Transcriptional regulator
ACPL_RS40290	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPL_RS40300	COG2801	Transposase and inactivated derivatives
ACPL_RS40305	COG3415	Transposase
ACPL_RS40305	COG2801	Transposase and inactivated derivatives
ACPL_RS40310	COG2801	Transposase and inactivated derivatives
ACPL_RS40415	COG1881	PFAM PEBP family protein
ACPL_RS40450	COG0789	Transcriptional regulator
ACPL_RS40455	COG3959	Transketolase, thiamine diphosphate binding domain
ACPL_RS40460	COG3958	Transketolase
ACPL_RS40490	COG0598	Magnesium transport protein CorA
ACPL_RS40495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACPL_RS40505	COG0371	Dehydrogenase
ACPL_RS40520	COG0438	transferase activity, transferring glycosyl groups
ACPL_RS40525	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACPL_RS40540	COG3275	phosphorelay sensor kinase activity
ACPL_RS40550	COG0745	RESPONSE REGULATOR receiver
ACPL_RS40555	COG2205	protein histidine kinase activity
ACPL_RS40570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACPL_RS40605	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACPL_RS40670	COG1764	response to oxidative stress
ACPL_RS40680	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACPL_RS40685	COG0561	phosphatase activity
ACPL_RS40690	COG0561	phosphatase activity
ACPL_RS40700	COG1834	amidinotransferase
ACPL_RS40705	COG1522	sequence-specific DNA binding
ACPL_RS40725	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ACPL_RS40745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACPL_RS40755	COG1408	metallophosphoesterase
ACPL_RS40800	COG0315	cyclic pyranopterin monophosphate synthase activity
ACPL_RS40800	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACPL_RS40805	COG0315	cyclic pyranopterin monophosphate synthase activity
ACPL_RS40810	COG5001	Diguanylate cyclase
ACPL_RS40850	COG0359	binds to the 23S rRNA
ACPL_RS40855	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACPL_RS40860	COG0629	single-stranded DNA binding
ACPL_RS40865	COG0360	Binds together with S18 to 16S ribosomal RNA
ACPL_RS40895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACPL_RS40905	COG1695	Transcriptional regulator
ACPL_RS40910	COG1260	myo-inositol-1-phosphate synthase
ACPL_RS40970	COG0617	tRNA 3'-terminal CCA addition
ACPL_RS40985	COG0515	serine threonine protein kinase
ACPL_RS40985	COG2815	serine threonine protein kinase
ACPL_RS40990	COG1595	DNA-templated transcription, initiation
ACPL_RS41005	COG3118	belongs to the thioredoxin family
ACPL_RS41010	COG3409	Peptidoglycan-binding domain 1 protein
ACPL_RS41010	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACPL_RS41020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACPL_RS41025	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACPL_RS41045	COG1192	Involved in chromosome partitioning
ACPL_RS41050	COG0357	Ribosomal RNA small subunit methyltransferase G
ACPL_RS41060	COG0706	membrane insertase activity
ACPL_RS41065	COG0594	ribonuclease P activity
ACPL_RS41070	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ACPL_RS41115	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACPL_RS41165	COG0515	serine threonine protein kinase
ACPL_RS41165	COG2815	serine threonine protein kinase
ACPL_RS41180	COG0604	alcohol dehydrogenase
ACPL_RS41185	COG3321	synthase
ACPL_RS41185	COG0604	alcohol dehydrogenase
ACPL_RS41185	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS41190	COG5001	Diguanylate cyclase
ACPL_RS41215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_RS41245	COG5001	Diguanylate cyclase
ACPL_RS41245	COG5002	protein histidine kinase activity
ACPL_RS41260	COG1797	cobyrinic acid a,c-diamide synthase activity
ACPL_RS41370	COG2203	Gaf domain
ACPL_RS41370	COG2199	diguanylate cyclase activity
ACPL_RS41375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACPL_RS41440	COG1051	belongs to the nudix hydrolase family
ACPL_RS41455	COG5001	Diguanylate cyclase
ACPL_RS41455	COG3300	MHYT domain
ACPL_RS41515	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_RS41550	COG4988	ABC transporter
ACPL_RS41560	COG3903	Transcriptional regulator
ACPL_RS41560	COG3629	intracellular signal transduction
ACPL_RS41620	COG2205	protein histidine kinase activity
ACPL_RS41620	COG5002	protein histidine kinase activity
ACPL_RS41620	COG0784	Response regulator, receiver
ACPL_RS41625	COG5001	Diguanylate cyclase
ACPL_RS41625	COG3300	MHYT domain
ACPL_RS41635	COG0784	Response regulator, receiver
ACPL_RS41635	COG4191	Histidine kinase
ACPL_RS41645	COG3706	GGDEF domain
ACPL_RS41670	COG5001	Diguanylate cyclase
ACPL_RS41705	COG5001	Diguanylate cyclase
ACPL_RS41705	COG3300	MHYT domain
ACPL_RS41715	COG3209	COG3209 Rhs family protein
ACPL_RS41730	COG1940	carbohydrate kinase activity
ACPL_RS41735	COG1082	Xylose isomerase domain protein TIM barrel
ACPL_RS41755	COG3706	GGDEF domain
ACPL_RS41860	COG0681	Belongs to the peptidase S26 family
ACPL_RS41905	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACPL_RS41935	COG3447	MASE1 domain protein
ACPL_RS41935	COG5002	protein histidine kinase activity
ACPL_RS41935	COG5001	Diguanylate cyclase
ACPL_RS41940	COG0789	Transcriptional regulator
ACPL_RS42060	COG1674	ftsk spoiiie
ACPL_RS42150	COG5479	isomerase activity
ACPL_RS42150	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ACPL_RS42155	COG0515	serine threonine protein kinase
ACPL_RS42205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ACPL_RS42250	COG1196	nuclear chromosome segregation
ACPL_RS42250	COG0741	lytic transglycosylase activity
ACPL_RS42250	COG0739	heme binding
ACPL_RS42265	COG1674	ftsk spoiiie
ACPL_RS42365	COG1216	Glycosyl transferase, family 2
ACPL_RS42375	COG0515	serine threonine protein kinase
ACPL_RS42430	COG5002	protein histidine kinase activity
ACPL_RS42510	COG0438	transferase activity, transferring glycosyl groups