locus-tag	class	description
APASM_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APASM_RS00010	COG0592	DNA-directed DNA polymerase activity
APASM_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
APASM_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APASM_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
APASM_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APASM_RS00055	COG2259	Doxx family
APASM_RS00070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APASM_RS00075	COG0705	Rhomboid family
APASM_RS00090	COG3764	Sortase (surface protein transpeptidase)
APASM_RS00105	COG0515	serine threonine protein kinase
APASM_RS00105	COG2815	serine threonine protein kinase
APASM_RS00110	COG0515	serine threonine protein kinase
APASM_RS00115	COG0768	penicillin binding
APASM_RS00130	COG1716	ATPase activity
APASM_RS00135	COG1716	ATPase activity
APASM_RS00165	COG1309	transcriptional regulator
APASM_RS00175	COG2211	Major facilitator Superfamily
APASM_RS00180	COG0300	oxidoreductase activity
APASM_RS00200	COG3281	Trehalose synthase
APASM_RS00250	COG0405	Gamma-glutamyltransferase
APASM_RS00280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APASM_RS00295	COG2226	methyltransferase
APASM_RS00330	COG3275	phosphorelay sensor kinase activity
APASM_RS00340	COG3279	Response regulator of the LytR AlgR family
APASM_RS00350	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APASM_RS00360	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APASM_RS00385	COG0584	glycerophosphoryl diester phosphodiesterase
APASM_RS00400	COG0653	protein targeting
APASM_RS00415	COG1528	Iron-storage protein
APASM_RS00465	COG1271	oxidase subunit
APASM_RS00470	COG1294	oxidase, subunit
APASM_RS00480	COG4988	ABC transporter
APASM_RS00495	COG0454	-acetyltransferase
APASM_RS00555	COG1501	Belongs to the glycosyl hydrolase 31 family
APASM_RS00590	COG0754	glutathionylspermidine amidase activity
APASM_RS00595	COG3766	membrane
APASM_RS00605	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APASM_RS00620	COG0579	oxidoreductase
APASM_RS00630	COG0561	phosphatase activity
APASM_RS00640	COG0463	Glycosyl transferase, family 2
APASM_RS00660	COG1216	Glycosyl transferase, family 2
APASM_RS00690	COG1216	Glycosyl transferase, family 2
APASM_RS00735	COG2234	aminopeptidase activity
APASM_RS00745	COG1525	nuclease
APASM_RS00745	COG0737	Belongs to the 5'-nucleotidase family
APASM_RS00745	COG4085	toxin activity
APASM_RS00765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APASM_RS00790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APASM_RS00810	COG1686	Belongs to the peptidase S11 family
APASM_RS00815	COG5295	Hep Hag repeat protein
APASM_RS00815	COG4932	domain protein
APASM_RS00860	COG0183	Belongs to the thiolase family
APASM_RS00875	COG0287	Prephenate dehydrogenase
APASM_RS00880	COG1473	amidohydrolase
APASM_RS00945	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APASM_RS00950	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APASM_RS00975	COG3629	intracellular signal transduction
APASM_RS00975	COG3903	Transcriptional regulator
APASM_RS00980	COG0747	negative chemotaxis
APASM_RS00985	COG0601	transmembrane transport
APASM_RS00990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APASM_RS00995	COG0444	Belongs to the ABC transporter superfamily
APASM_RS01000	COG4608	Belongs to the ABC transporter superfamily
APASM_RS01005	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APASM_RS01050	COG1070	Carbohydrate kinase
APASM_RS01055	COG1278	Cold shock
APASM_RS01070	COG1764	response to oxidative stress
APASM_RS01080	COG0431	NADPH-dependent FMN reductase
APASM_RS01125	COG1408	metallophosphoesterase
APASM_RS01215	COG0592	DNA-directed DNA polymerase activity
APASM_RS01220	COG2814	Major facilitator Superfamily
APASM_RS01240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APASM_RS01255	COG0596	Alpha beta hydrolase
APASM_RS01265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APASM_RS01270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APASM_RS01285	COG3844	kynureninase activity
APASM_RS01295	COG1522	sequence-specific DNA binding
APASM_RS01300	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
APASM_RS01305	COG1737	Transcriptional regulator
APASM_RS01315	COG3876	Protein conserved in bacteria
APASM_RS01320	COG1472	Belongs to the glycosyl hydrolase 3 family
APASM_RS01375	COG1205	dead DEAH box helicase
APASM_RS01375	COG1111	helicase
APASM_RS01380	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
APASM_RS01415	COG1754	DNA topoisomerase type I activity
APASM_RS01415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APASM_RS01425	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APASM_RS01430	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APASM_RS01450	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
APASM_RS01455	COG1120	ATPase activity
APASM_RS01495	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APASM_RS01505	COG2027	D-alanyl-D-alanine carboxypeptidase
APASM_RS01515	COG0037	tRNA processing
APASM_RS01520	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
APASM_RS01530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APASM_RS01535	COG0302	gtp cyclohydrolase
APASM_RS01540	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APASM_RS01545	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APASM_RS01565	COG0649	NAD binding
APASM_RS01590	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
APASM_RS01595	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
APASM_RS01600	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
APASM_RS01610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APASM_RS01620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_RS01625	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_RS01630	COG1120	ATPase activity
APASM_RS01645	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
APASM_RS01655	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APASM_RS01685	COG1194	a g-specific adenine glycosylase
APASM_RS01700	COG1609	Transcriptional regulator
APASM_RS01710	COG1653	transport
APASM_RS01720	COG3833	ABC-type maltose transport systems, permease component
APASM_RS01725	COG3842	ATPase activity
APASM_RS01735	COG1121	(ABC) transporter
APASM_RS01740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APASM_RS01770	COG0215	cysteine-tRNA ligase activity
APASM_RS01780	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APASM_RS01785	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APASM_RS01790	COG1329	Transcriptional regulator
APASM_RS01810	COG4221	oxidoreductase activity
APASM_RS01830	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
APASM_RS01865	COG2205	protein histidine kinase activity
APASM_RS01870	COG0745	RESPONSE REGULATOR receiver
APASM_RS01900	COG3903	Transcriptional regulator
APASM_RS01900	COG3629	intracellular signal transduction
APASM_RS01920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_RS01925	COG0583	DNA-binding transcription factor activity
APASM_RS01940	COG0179	Fumarylacetoacetate (FAA) hydrolase
APASM_RS01945	COG4948	Mandelate Racemase Muconate Lactonizing
APASM_RS01950	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS01970	COG2186	Transcriptional regulator
APASM_RS01975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APASM_RS01980	COG0395	ABC-type sugar transport system, permease component
APASM_RS01985	COG1175	transmembrane transport
APASM_RS01990	COG2182	Extracellular solute-binding protein
APASM_RS01995	COG2188	Transcriptional regulator
APASM_RS02000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APASM_RS02005	COG3384	dioxygenase
APASM_RS02010	COG0352	thiamine-phosphate diphosphorylase activity
APASM_RS02015	COG2022	thiamine diphosphate biosynthetic process
APASM_RS02015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APASM_RS02025	COG2022	thiamine diphosphate biosynthetic process
APASM_RS02035	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
APASM_RS02060	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS02090	COG0351	phosphomethylpyrimidine kinase
APASM_RS02095	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
APASM_RS02120	COG1802	Transcriptional regulator
APASM_RS02130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APASM_RS02150	COG0688	phosphatidylethanolamine metabolic process
APASM_RS02170	COG1278	Cold shock
APASM_RS02180	COG0459	protein refolding
APASM_RS02195	COG3142	Participates in the control of copper homeostasis
APASM_RS02205	COG1175	transmembrane transport
APASM_RS02210	COG0395	ABC-type sugar transport system, permease component
APASM_RS02215	COG3525	Glycosyl hydrolase, family 20, catalytic domain
APASM_RS02235	COG4948	Mandelate Racemase Muconate Lactonizing
APASM_RS02270	COG2018	Roadblock/LC7 domain
APASM_RS02310	COG0315	cyclic pyranopterin monophosphate synthase activity
APASM_RS02310	COG0521	Mo-molybdopterin cofactor biosynthetic process
APASM_RS02320	COG1388	LysM domain
APASM_RS02330	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APASM_RS02335	COG1846	Transcriptional regulator
APASM_RS02360	COG3304	Inner membrane component domain
APASM_RS02380	COG1278	Cold shock
APASM_RS02390	COG2814	Major facilitator Superfamily
APASM_RS02420	COG2252	PERMEase
APASM_RS02430	COG2814	Major facilitator Superfamily
APASM_RS02445	COG0488	(ABC) transporter
APASM_RS02460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APASM_RS02480	COG5492	domain, Protein
APASM_RS02485	COG0259	pyridoxamine-phosphate oxidase activity
APASM_RS02490	COG0829	nickel cation binding
APASM_RS02500	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APASM_RS02510	COG0804	urea catabolic process
APASM_RS02515	COG0832	Belongs to the urease beta subunit family
APASM_RS02520	COG0831	urea catabolic process
APASM_RS02545	COG2197	response regulator
APASM_RS02575	COG1132	(ABC) transporter
APASM_RS02580	COG1132	(ABC) transporter
APASM_RS02595	COG1309	transcriptional regulator
APASM_RS02600	COG0531	amino acid
APASM_RS02605	COG2017	converts alpha-aldose to the beta-anomer
APASM_RS02610	COG1228	amidohydrolase
APASM_RS02615	COG1960	acyl-CoA dehydrogenase activity
APASM_RS02635	COG0415	Belongs to the DNA photolyase family
APASM_RS02640	COG2197	response regulator
APASM_RS02650	COG1668	transmembrane transport
APASM_RS02655	COG4152	abc transporter atp-binding protein
APASM_RS02680	COG0402	S-adenosylhomocysteine deaminase activity
APASM_RS02685	COG2130	NADP-dependent
APASM_RS02700	COG1674	ftsk spoiiie
APASM_RS02735	COG2267	carboxylic ester hydrolase activity
APASM_RS02740	COG0583	DNA-binding transcription factor activity
APASM_RS02745	COG0384	phenazine biosynthesis protein PhzF
APASM_RS02750	COG0583	DNA-binding transcription factor activity
APASM_RS02755	COG0702	epimerase
APASM_RS02760	COG1733	regulation of RNA biosynthetic process
APASM_RS02795	COG2197	response regulator
APASM_RS02860	COG3209	COG3209 Rhs family protein
APASM_RS02945	COG2197	response regulator
APASM_RS02955	COG0778	Nitroreductase
APASM_RS02960	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APASM_RS02965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APASM_RS02975	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APASM_RS02980	COG0588	phosphoglycerate mutase activity
APASM_RS03005	COG2205	protein histidine kinase activity
APASM_RS03010	COG0395	ABC-type sugar transport system, permease component
APASM_RS03015	COG1175	transmembrane transport
APASM_RS03020	COG1653	transport
APASM_RS03030	COG1349	DNA-binding transcription factor activity
APASM_RS03040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APASM_RS03050	COG0315	cyclic pyranopterin monophosphate synthase activity
APASM_RS03050	COG0521	Mo-molybdopterin cofactor biosynthetic process
APASM_RS03055	COG1970	mechanosensitive ion channel activity
APASM_RS03070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APASM_RS03075	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APASM_RS03085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APASM_RS03115	COG0515	serine threonine protein kinase
APASM_RS03150	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APASM_RS03155	COG0084	hydrolase, TatD family'
APASM_RS03160	COG3583	domain protein
APASM_RS03165	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APASM_RS03170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APASM_RS03175	COG2011	ABC-type metal ion transport system permease component
APASM_RS03185	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APASM_RS03190	COG0488	(ABC) transporter
APASM_RS03195	COG3599	regulation of cell shape
APASM_RS03205	COG0318	PFAM AMP-dependent synthetase and ligase
APASM_RS03210	COG0193	aminoacyl-tRNA hydrolase activity
APASM_RS03230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APASM_RS03265	COG2133	pyrroloquinoline quinone binding
APASM_RS03285	COG3956	TIGRFAM MazG family protein
APASM_RS03290	COG4946	Tricorn protease homolog
APASM_RS03290	COG0793	Belongs to the peptidase S41A family
APASM_RS03305	COG0148	phosphopyruvate hydratase activity
APASM_RS03330	COG4166	transmembrane transport
APASM_RS03335	COG0601	transmembrane transport
APASM_RS03340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APASM_RS03350	COG4608	Belongs to the ABC transporter superfamily
APASM_RS03380	COG0714	Associated with various cellular activities
APASM_RS03445	COG0183	Belongs to the thiolase family
APASM_RS03475	COG3185	4-Hydroxyphenylpyruvate dioxygenase
APASM_RS03485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APASM_RS03495	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
APASM_RS03510	COG1331	Highly conserved protein containing a thioredoxin domain
APASM_RS03520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APASM_RS03535	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
APASM_RS03545	COG1793	dna ligase
APASM_RS03550	COG0114	fumarate hydratase activity
APASM_RS03555	COG0492	ferredoxin-NADP+ reductase activity
APASM_RS03575	COG1722	exodeoxyribonuclease VII activity
APASM_RS03585	COG1570	exodeoxyribonuclease VII activity
APASM_RS03615	COG0419	ATPase involved in DNA repair
APASM_RS03630	COG0012	GTP binding
APASM_RS03660	COG1051	belongs to the nudix hydrolase family
APASM_RS03670	COG2154	pterin-4-alpha-carbinolamine dehydratase
APASM_RS03680	COG4149	molybdate abc transporter
APASM_RS03685	COG3842	ATPase activity
APASM_RS03715	COG1131	(ABC) transporter
APASM_RS03735	COG0494	nUDIX hydrolase
APASM_RS03745	COG0180	Tryptophanyl-tRNA synthetase
APASM_RS03755	COG1217	gtp-binding protein TYPA
APASM_RS03760	COG0747	negative chemotaxis
APASM_RS03765	COG4166	transmembrane transport
APASM_RS03785	COG4608	Belongs to the ABC transporter superfamily
APASM_RS03790	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
APASM_RS03825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APASM_RS03830	COG1611	Belongs to the LOG family
APASM_RS03835	COG1611	Belongs to the LOG family
APASM_RS03845	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APASM_RS03865	COG0519	Catalyzes the synthesis of GMP from XMP
APASM_RS03890	COG1024	Enoyl-CoA hydratase
APASM_RS03895	COG3327	negative regulation of DNA-templated transcription, initiation
APASM_RS03905	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APASM_RS03910	COG0583	DNA-binding transcription factor activity
APASM_RS03915	COG2814	Major facilitator Superfamily
APASM_RS03930	COG0297	glycogen (starch) synthase activity
APASM_RS03935	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APASM_RS03950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APASM_RS03955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APASM_RS03975	COG2239	Acts as a magnesium transporter
APASM_RS03980	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
APASM_RS04040	COG0598	Magnesium transport protein CorA
APASM_RS04075	COG0513	Belongs to the DEAD box helicase family
APASM_RS04110	COG2267	carboxylic ester hydrolase activity
APASM_RS04130	COG0243	molybdopterin cofactor binding
APASM_RS04135	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APASM_RS04140	COG2223	nitrite transmembrane transporter activity
APASM_RS04145	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APASM_RS04145	COG2146	nitrite reductase [NAD(P)H] activity
APASM_RS04150	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APASM_RS04150	COG2146	nitrite reductase [NAD(P)H] activity
APASM_RS04175	COG0745	RESPONSE REGULATOR receiver
APASM_RS04180	COG2205	protein histidine kinase activity
APASM_RS04215	COG0210	DNA helicase
APASM_RS04230	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS04235	COG0583	DNA-binding transcription factor activity
APASM_RS04275	COG0612	Peptidase, M16
APASM_RS04285	COG1940	carbohydrate kinase activity
APASM_RS04285	COG1846	Transcriptional regulator
APASM_RS04315	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
APASM_RS04360	COG0431	NADPH-dependent FMN reductase
APASM_RS04400	COG0791	NLP P60 protein
APASM_RS04420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APASM_RS04450	COG3842	ATPase activity
APASM_RS04475	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
APASM_RS04495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
APASM_RS04495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APASM_RS04500	COG0174	glutamine synthetase
APASM_RS04530	COG1522	sequence-specific DNA binding
APASM_RS04540	COG0519	Catalyzes the synthesis of GMP from XMP
APASM_RS04540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APASM_RS04555	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
APASM_RS04620	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APASM_RS04650	COG1615	UPF0182 protein
APASM_RS04680	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APASM_RS04685	COG2884	Cell division ATP-binding protein ftsE
APASM_RS04690	COG2177	Part of the ABC transporter FtsEX involved in
APASM_RS04695	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APASM_RS04700	COG2197	response regulator
APASM_RS04705	COG4585	Histidine kinase
APASM_RS04720	COG1643	Atp-dependent helicase
APASM_RS04730	COG0456	acetyltransferase
APASM_RS04730	COG0454	-acetyltransferase
APASM_RS04735	COG2814	Major facilitator Superfamily
APASM_RS04745	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
APASM_RS04840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APASM_RS04850	COG1111	helicase
APASM_RS04850	COG1205	dead DEAH box helicase
APASM_RS04855	COG0210	DNA helicase
APASM_RS04860	COG3629	intracellular signal transduction
APASM_RS04860	COG3903	Transcriptional regulator
APASM_RS04895	COG1175	transmembrane transport
APASM_RS04900	COG0395	ABC-type sugar transport system, permease component
APASM_RS04910	COG3254	rhamnose metabolic process
APASM_RS04915	COG1609	Transcriptional regulator
APASM_RS04955	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
APASM_RS04960	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
APASM_RS04965	COG0235	Class ii aldolase
APASM_RS04970	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
APASM_RS04980	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APASM_RS04985	COG3830	Belongs to the UPF0237 family
APASM_RS04985	COG0560	Phosphoserine phosphatase
APASM_RS05045	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
APASM_RS05055	COG1335	isochorismatase
APASM_RS05060	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
APASM_RS05065	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
APASM_RS05100	COG1234	tRNA 3'-trailer cleavage
APASM_RS05105	COG3386	PFAM SMP-30 Gluconolaconase
APASM_RS05115	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
APASM_RS05120	COG1234	tRNA 3'-trailer cleavage
APASM_RS05140	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
APASM_RS05145	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APASM_RS05165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_RS05170	COG2072	flavoprotein involved in K transport
APASM_RS05175	COG0586	Pfam SNARE associated Golgi protein
APASM_RS05225	COG2949	membrane
APASM_RS05230	COG1316	TRANSCRIPTIONal
APASM_RS05235	COG0751	glycine-tRNA ligase activity
APASM_RS05235	COG0752	glycyl-tRNA synthetase alpha subunit
APASM_RS05245	COG4213	ABC transporter substrate-binding protein
APASM_RS05255	COG1278	Cold shock
APASM_RS05265	COG3345	alpha-galactosidase
APASM_RS05275	COG4279	zinc finger
APASM_RS05280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APASM_RS05325	COG1376	ErfK ybiS ycfS ynhG family protein
APASM_RS05330	COG0488	(ABC) transporter
APASM_RS05340	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
APASM_RS05370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APASM_RS05370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APASM_RS05395	COG1846	Transcriptional regulator
APASM_RS05400	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
APASM_RS05420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APASM_RS05420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APASM_RS05460	COG4106	trans-aconitate 2-methyltransferase activity
APASM_RS05465	COG0506	proline dehydrogenase activity
APASM_RS05470	COG1012	belongs to the aldehyde dehydrogenase family
APASM_RS05480	COG0706	membrane insertase activity
APASM_RS05505	COG1012	belongs to the aldehyde dehydrogenase family
APASM_RS05550	COG0740	serine-type endopeptidase activity
APASM_RS05555	COG0740	serine-type endopeptidase activity
APASM_RS05570	COG1609	Transcriptional regulator
APASM_RS05575	COG2223	nitrite transmembrane transporter activity
APASM_RS05585	COG3336	cytochrome c oxidase
APASM_RS05620	COG2902	Dehydrogenase
APASM_RS05645	COG0366	Alpha amylase catalytic
APASM_RS05655	COG0668	transmembrane transport
APASM_RS05660	COG1505	serine-type exopeptidase activity
APASM_RS05680	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
APASM_RS05690	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
APASM_RS05720	COG4552	Acetyltransferase involved in intracellular survival and related
APASM_RS05740	COG0583	DNA-binding transcription factor activity
APASM_RS05745	COG0544	peptidyl-prolyl cis-trans isomerase activity
APASM_RS05750	COG0740	serine-type endopeptidase activity
APASM_RS05755	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APASM_RS05770	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
APASM_RS05805	COG0525	valine-tRNA ligase activity
APASM_RS05810	COG0285	dihydrofolate synthase activity
APASM_RS05950	COG0105	UTP biosynthetic process
APASM_RS05955	COG1131	(ABC) transporter
APASM_RS05965	COG0842	Transport permease protein
APASM_RS06015	COG1530	ribonuclease E activity
APASM_RS06015	COG1530	ribonuclease E activity
APASM_RS06020	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APASM_RS06025	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APASM_RS06030	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APASM_RS06040	COG0477	Major facilitator Superfamily
APASM_RS06055	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APASM_RS06070	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APASM_RS06075	COG0799	negative regulation of ribosome biogenesis
APASM_RS06085	COG2755	lipolytic protein G-D-S-L family
APASM_RS06090	COG1307	EDD domain protein, DegV family
APASM_RS06095	COG1555	photosystem II stabilization
APASM_RS06095	COG1596	polysaccharide export
APASM_RS06105	COG0658	competence protein
APASM_RS06105	COG2333	competence protein COMEC
APASM_RS06125	COG0268	Binds directly to 16S ribosomal RNA
APASM_RS06155	COG2308	Evidence 4 Homologs of previously reported genes of
APASM_RS06165	COG1305	Transglutaminase-like
APASM_RS06170	COG0481	GTPase activity
APASM_RS06185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APASM_RS06205	COG0531	amino acid
APASM_RS06215	COG0604	alcohol dehydrogenase
APASM_RS06230	COG2732	(Barnase) inhibitor
APASM_RS06250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APASM_RS06255	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
APASM_RS06285	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APASM_RS06300	COG0484	heat shock protein binding
APASM_RS06320	COG0596	Alpha beta hydrolase
APASM_RS06325	COG0537	adenosine 5'-monophosphoramidase activity
APASM_RS06340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APASM_RS06360	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APASM_RS06365	COG1381	Involved in DNA repair and RecF pathway recombination
APASM_RS06370	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APASM_RS06385	COG0701	Predicted permease
APASM_RS06420	COG0423	glycine-tRNA ligase activity
APASM_RS06445	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APASM_RS06455	COG3340	Belongs to the peptidase S51 family
APASM_RS06460	COG1595	DNA-templated transcription, initiation
APASM_RS06465	COG0358	DNA primase activity
APASM_RS06505	COG1674	ftsk spoiiie
APASM_RS06555	COG4106	trans-aconitate 2-methyltransferase activity
APASM_RS06565	COG1316	TRANSCRIPTIONal
APASM_RS06580	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
APASM_RS06595	COG5001	Diguanylate cyclase
APASM_RS06610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APASM_RS06615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APASM_RS06635	COG2084	Dehydrogenase
APASM_RS06670	COG1132	(ABC) transporter
APASM_RS06675	COG1132	(ABC) transporter
APASM_RS06685	COG0515	serine threonine protein kinase
APASM_RS06700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APASM_RS06705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APASM_RS06725	COG3201	nicotinamide mononucleotide transporter
APASM_RS06730	COG1653	transport
APASM_RS06735	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
APASM_RS06770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APASM_RS06790	COG0321	lipoyl(octanoyl) transferase activity
APASM_RS06805	COG0702	epimerase
APASM_RS06820	COG0508	dehydrogenase complex catalyzes the overall conversion of
APASM_RS06825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APASM_RS06850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APASM_RS06855	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
APASM_RS06870	COG0667	Aldo Keto reductase
APASM_RS06905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APASM_RS06915	COG0318	PFAM AMP-dependent synthetase and ligase
APASM_RS06915	COG0204	Acyl-transferase
APASM_RS06920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APASM_RS06935	COG1845	cytochrome c oxidase, subunit III
APASM_RS06940	COG2010	Cytochrome c
APASM_RS06950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APASM_RS06980	COG0438	transferase activity, transferring glycosyl groups
APASM_RS07005	COG0003	Pfam Anion-transporting ATPase
APASM_RS07015	COG1940	carbohydrate kinase activity
APASM_RS07050	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
APASM_RS07075	COG0142	geranyltranstransferase activity
APASM_RS07085	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APASM_RS07110	COG0442	prolyl-tRNA aminoacylation
APASM_RS07145	COG1201	RNA secondary structure unwinding
APASM_RS07155	COG0443	Heat shock 70 kDa protein
APASM_RS07160	COG2814	Major facilitator Superfamily
APASM_RS07170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APASM_RS07175	COG2137	regulation of response to DNA damage stimulus
APASM_RS07185	COG0800	Aldolase
APASM_RS07225	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APASM_RS07230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APASM_RS07240	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APASM_RS07250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APASM_RS07265	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
APASM_RS07270	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APASM_RS07280	COG1196	nuclear chromosome segregation
APASM_RS07290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APASM_RS07295	COG2358	TRAP transporter, solute receptor (TAXI family
APASM_RS07300	COG0642	Histidine kinase
APASM_RS07305	COG0745	RESPONSE REGULATOR receiver
APASM_RS07310	COG1126	abc transporter atp-binding protein
APASM_RS07320	COG0765	amino acid transport
APASM_RS07325	COG0765	amino acid transport
APASM_RS07355	COG1515	deoxyribonuclease V activity
APASM_RS07360	COG1486	melibiose metabolic process
APASM_RS07365	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
APASM_RS07370	COG2936	dipeptidyl-peptidase activity
APASM_RS07380	COG4946	Tricorn protease homolog
APASM_RS07380	COG1506	peptidase
APASM_RS07380	COG0823	Involved in the tonB-independent uptake of proteins
APASM_RS07385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APASM_RS07390	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
APASM_RS07410	COG0123	including yeast histone deacetylase and acetoin utilization protein
APASM_RS07420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APASM_RS07425	COG2188	Transcriptional regulator
APASM_RS07445	COG1690	Belongs to the RtcB family
APASM_RS07495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APASM_RS07505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APASM_RS07510	COG4948	Mandelate Racemase Muconate Lactonizing
APASM_RS07540	COG1490	D-aminoacyl-tRNA deacylase activity
APASM_RS07545	COG2890	protein-(glutamine-N5) methyltransferase activity
APASM_RS07565	COG2313	pseudouridylate synthase activity
APASM_RS07580	COG1061	Type III restriction enzyme res subunit
APASM_RS07595	COG4214	carbohydrate transport
APASM_RS07645	COG0756	dUTP diphosphatase activity
APASM_RS07675	COG0569	domain protein
APASM_RS07680	COG0531	amino acid
APASM_RS07685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APASM_RS07690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APASM_RS07700	COG0745	RESPONSE REGULATOR receiver
APASM_RS07705	COG2205	protein histidine kinase activity
APASM_RS07790	COG1024	Enoyl-CoA hydratase
APASM_RS07790	COG1250	3-hydroxyacyl-CoA dehydrogenase
APASM_RS07795	COG0183	Belongs to the thiolase family
APASM_RS07815	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
APASM_RS07835	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APASM_RS07840	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
APASM_RS07845	COG3253	May function as heme-dependent peroxidase
APASM_RS07850	COG1404	Belongs to the peptidase S8 family
APASM_RS07870	COG3220	belongs to the UPF0276 family
APASM_RS07900	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APASM_RS07920	COG1960	acyl-CoA dehydrogenase activity
APASM_RS07925	COG1960	acyl-CoA dehydrogenase activity
APASM_RS07930	COG3285	dna ligase
APASM_RS07930	COG1793	dna ligase
APASM_RS07970	COG1793	dna ligase
APASM_RS07990	COG0488	(ABC) transporter
APASM_RS08000	COG2706	6-phosphogluconolactonase activity
APASM_RS08005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APASM_RS08030	COG1316	TRANSCRIPTIONal
APASM_RS08060	COG0653	protein targeting
APASM_RS08075	COG1960	acyl-CoA dehydrogenase activity
APASM_RS08100	COG1309	transcriptional regulator
APASM_RS08145	COG0475	glutathione-regulated potassium exporter activity
APASM_RS08165	COG1160	GTP binding
APASM_RS08170	COG2197	response regulator
APASM_RS08175	COG4585	Histidine kinase
APASM_RS08205	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APASM_RS08285	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APASM_RS08300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APASM_RS08365	COG1132	(ABC) transporter
APASM_RS08385	COG2963	transposase activity
APASM_RS08395	COG2826	transposase and inactivated derivatives, IS30 family
APASM_RS08420	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APASM_RS08435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APASM_RS08440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APASM_RS08450	COG0438	transferase activity, transferring glycosyl groups
APASM_RS08460	COG1215	transferase activity, transferring glycosyl groups
APASM_RS08495	COG1131	(ABC) transporter
APASM_RS08505	COG2197	response regulator
APASM_RS08580	COG2197	response regulator
APASM_RS08670	COG0328	RNA-DNA hybrid ribonuclease activity
APASM_RS08685	COG3345	alpha-galactosidase
APASM_RS08690	COG3629	intracellular signal transduction
APASM_RS08690	COG3903	Transcriptional regulator
APASM_RS08765	COG0601	transmembrane transport
APASM_RS08770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APASM_RS08775	COG0444	Belongs to the ABC transporter superfamily
APASM_RS08810	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
APASM_RS08815	COG2318	DinB family
APASM_RS08820	COG2255	four-way junction helicase activity
APASM_RS08825	COG0632	four-way junction helicase activity
APASM_RS08850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APASM_RS08855	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APASM_RS08860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APASM_RS08865	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APASM_RS08875	COG0124	histidyl-tRNA synthetase
APASM_RS08930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
APASM_RS08935	COG0439	Biotin carboxylase
APASM_RS08960	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APASM_RS08975	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
APASM_RS08980	COG2205	protein histidine kinase activity
APASM_RS08985	COG0745	RESPONSE REGULATOR receiver
APASM_RS08995	COG2372	response to copper ion
APASM_RS09020	COG0673	inositol 2-dehydrogenase activity
APASM_RS09035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APASM_RS09050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APASM_RS09085	COG2244	polysaccharide biosynthetic process
APASM_RS09175	COG0667	Aldo Keto reductase
APASM_RS09180	COG0596	Alpha beta hydrolase
APASM_RS09180	COG2226	methyltransferase
APASM_RS09180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APASM_RS09185	COG1024	Enoyl-CoA hydratase
APASM_RS09205	COG1295	ribonuclease BN
APASM_RS09220	COG1126	abc transporter atp-binding protein
APASM_RS09225	COG0765	amino acid transport
APASM_RS09235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APASM_RS09270	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APASM_RS09290	COG0395	ABC-type sugar transport system, permease component
APASM_RS09295	COG2723	6-phospho-beta-galactosidase activity
APASM_RS09315	COG5416	Lipopolysaccharide assembly protein A domain
APASM_RS09320	COG4249	Peptidase C14 caspase catalytic subunit p20
APASM_RS09320	COG2319	Wd-40 repeat
APASM_RS09325	COG1940	carbohydrate kinase activity
APASM_RS09335	COG2115	Belongs to the xylose isomerase family
APASM_RS09340	COG1070	Carbohydrate kinase
APASM_RS09365	COG2207	Transcriptional regulator
APASM_RS09365	COG3708	Transcriptional regulator
APASM_RS09415	COG0640	Transcriptional regulator
APASM_RS09455	COG0791	NLP P60 protein
APASM_RS09475	COG1609	Transcriptional regulator
APASM_RS09480	COG1609	Transcriptional regulator
APASM_RS09485	COG1472	Belongs to the glycosyl hydrolase 3 family
APASM_RS09495	COG3458	cephalosporin-C deacetylase activity
APASM_RS09520	COG4941	Belongs to the sigma-70 factor family
APASM_RS09550	COG0492	ferredoxin-NADP+ reductase activity
APASM_RS09555	COG1785	Belongs to the alkaline phosphatase family
APASM_RS09575	COG4677	pectinesterase activity
APASM_RS09585	COG0395	ABC-type sugar transport system, permease component
APASM_RS09595	COG4948	Mandelate Racemase Muconate Lactonizing
APASM_RS09620	COG1172	Belongs to the binding-protein-dependent transport system permease family
APASM_RS09625	COG1172	Belongs to the binding-protein-dependent transport system permease family
APASM_RS09635	COG1879	ABC-type sugar transport system periplasmic component
APASM_RS09650	COG3940	Belongs to the glycosyl hydrolase 43 family
APASM_RS09660	COG1609	Transcriptional regulator
APASM_RS09675	COG2160	L-arabinose isomerase activity
APASM_RS09680	COG4213	ABC transporter substrate-binding protein
APASM_RS09690	COG4214	carbohydrate transport
APASM_RS09700	COG3401	FG-GAP repeat protein
APASM_RS09715	COG1609	Transcriptional regulator
APASM_RS09745	COG2356	endonuclease I
APASM_RS09755	COG4585	Histidine kinase
APASM_RS09775	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APASM_RS09780	COG4715	Zinc finger, swim domain protein
APASM_RS09785	COG3552	Protein containing von Willebrand factor type A (VWA) domain
APASM_RS09790	COG2425	protein containing a von Willebrand factor type A (vWA) domain
APASM_RS09795	COG0714	Associated with various cellular activities
APASM_RS09805	COG3831	ATPase activity
APASM_RS09810	COG3831	ATPase activity
APASM_RS09815	COG0438	transferase activity, transferring glycosyl groups
APASM_RS09840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APASM_RS09855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APASM_RS09860	COG2326	polyphosphate kinase activity
APASM_RS09865	COG2261	transglycosylase associated protein
APASM_RS09945	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
APASM_RS09950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APASM_RS09955	COG0515	serine threonine protein kinase
APASM_RS09955	COG2815	serine threonine protein kinase
APASM_RS09965	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
APASM_RS09965	COG2755	lipolytic protein G-D-S-L family
APASM_RS09975	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
APASM_RS10000	COG0395	ABC-type sugar transport system, permease component
APASM_RS10010	COG0702	epimerase
APASM_RS10020	COG0745	RESPONSE REGULATOR receiver
APASM_RS10040	COG2197	response regulator
APASM_RS10045	COG4585	Histidine kinase
APASM_RS10055	COG1131	(ABC) transporter
APASM_RS10120	COG0477	Major facilitator Superfamily
APASM_RS10160	COG2124	cytochrome p450
APASM_RS10165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APASM_RS10185	COG1846	Transcriptional regulator
APASM_RS10220	COG2197	response regulator
APASM_RS10235	COG2264	protein methyltransferase activity
APASM_RS10265	COG0395	ABC-type sugar transport system, permease component
APASM_RS10270	COG4209	transmembrane transport
APASM_RS10280	COG1609	Transcriptional regulator
APASM_RS10325	COG1011	Hydrolase
APASM_RS10340	COG1295	ribonuclease BN
APASM_RS10350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APASM_RS10355	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
APASM_RS10370	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APASM_RS10380	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APASM_RS10395	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
APASM_RS10420	COG2197	response regulator
APASM_RS10435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APASM_RS10465	COG1595	DNA-templated transcription, initiation
APASM_RS10595	COG2188	Transcriptional regulator
APASM_RS10600	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APASM_RS10630	COG1834	amidinotransferase
APASM_RS10635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APASM_RS10645	COG3483	tryptophan 2,3-dioxygenase activity
APASM_RS10665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APASM_RS10710	COG2181	nitrate reductase activity
APASM_RS10715	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
APASM_RS10720	COG1140	nitrate reductase beta subunit
APASM_RS10755	COG3250	beta-galactosidase activity
APASM_RS10760	COG5297	Belongs to the glycosyl hydrolase family 6
APASM_RS10765	COG1732	Glycine betaine
APASM_RS10770	COG1174	glycine betaine transport
APASM_RS10780	COG1174	glycine betaine transport
APASM_RS10810	COG3842	ATPase activity
APASM_RS10830	COG0590	tRNA wobble adenosine to inosine editing
APASM_RS10850	COG3835	regulator
APASM_RS10880	COG0492	ferredoxin-NADP+ reductase activity
APASM_RS10890	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
APASM_RS10905	COG0531	amino acid
APASM_RS10915	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
APASM_RS10930	COG2186	Transcriptional regulator
APASM_RS10975	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APASM_RS10990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APASM_RS10995	COG1560	Kdo2-lipid A biosynthetic process
APASM_RS11000	COG0438	transferase activity, transferring glycosyl groups
APASM_RS11005	COG1051	belongs to the nudix hydrolase family
APASM_RS11025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APASM_RS11035	COG1953	Uracil, thiamine, allantoin
APASM_RS11080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
APASM_RS11085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
APASM_RS11090	COG0217	transcriptional regulatory protein
APASM_RS11105	COG1309	transcriptional regulator
APASM_RS11110	COG0477	Major facilitator Superfamily
APASM_RS11120	COG2124	cytochrome p450
APASM_RS11150	COG3572	ergothioneine biosynthetic process
APASM_RS11155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APASM_RS11165	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
APASM_RS11205	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APASM_RS11230	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APASM_RS11240	COG0318	PFAM AMP-dependent synthetase and ligase
APASM_RS11245	COG0791	NLP P60 protein
APASM_RS11245	COG3883	PFAM NLP P60 protein
APASM_RS11260	COG0746	molybdenum cofactor guanylyltransferase activity
APASM_RS11265	COG0500	methyltransferase
APASM_RS11270	COG0714	Associated with various cellular activities
APASM_RS11280	COG2304	oxidoreductase activity
APASM_RS11295	COG5002	protein histidine kinase activity
APASM_RS11350	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APASM_RS11370	COG3012	SEC-C Motif Domain Protein
APASM_RS11380	COG4733	cellulase activity
APASM_RS11380	COG5297	Belongs to the glycosyl hydrolase family 6
APASM_RS11385	COG1472	Belongs to the glycosyl hydrolase 3 family
APASM_RS11400	COG4209	transmembrane transport
APASM_RS11405	COG0395	ABC-type sugar transport system, permease component
APASM_RS11420	COG1324	tolerance protein
APASM_RS11425	COG0789	Transcriptional regulator
APASM_RS11440	COG0247	lactate metabolic process
APASM_RS11440	COG0277	FAD linked oxidase domain protein
APASM_RS11450	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APASM_RS11455	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APASM_RS11470	COG4221	oxidoreductase activity
APASM_RS11505	COG5297	Belongs to the glycosyl hydrolase family 6
APASM_RS11510	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
APASM_RS11545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APASM_RS11565	COG0215	cysteine-tRNA ligase activity
APASM_RS11595	COG0745	RESPONSE REGULATOR receiver
APASM_RS11600	COG0745	RESPONSE REGULATOR receiver
APASM_RS11605	COG5002	protein histidine kinase activity
APASM_RS11615	COG1410	methionine synthase
APASM_RS11615	COG0646	methionine synthase
APASM_RS11620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APASM_RS11635	COG1902	pentaerythritol trinitrate reductase activity
APASM_RS11635	COG0446	pyridine nucleotide-disulphide oxidoreductase
APASM_RS11650	COG0140	phosphoribosyl-ATP diphosphatase activity
APASM_RS11680	COG1994	Peptidase M50
APASM_RS11680	COG0517	IMP dehydrogenase activity
APASM_RS11685	COG0300	oxidoreductase activity
APASM_RS11690	COG2197	response regulator
APASM_RS11725	COG1222	aaa ATPase
APASM_RS11730	COG2197	response regulator
APASM_RS11735	COG4585	Histidine kinase
APASM_RS11775	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
APASM_RS11780	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
APASM_RS11785	COG4221	oxidoreductase activity
APASM_RS11800	COG1672	PFAM Archaeal ATPase
APASM_RS11800	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
APASM_RS11810	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
APASM_RS11825	COG2378	regulation of single-species biofilm formation
APASM_RS11835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APASM_RS11865	COG4552	Acetyltransferase involved in intracellular survival and related
APASM_RS11895	COG3706	GGDEF domain
APASM_RS11920	COG2357	RelA SpoT domain protein
APASM_RS11940	COG1846	Transcriptional regulator
APASM_RS11945	COG0714	Associated with various cellular activities
APASM_RS11955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APASM_RS11980	COG0187	DNA topoisomerase II activity
APASM_RS12010	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APASM_RS12015	COG5001	Diguanylate cyclase
APASM_RS12015	COG1716	ATPase activity
APASM_RS12035	COG3845	ABC transporter
APASM_RS12055	COG2226	methyltransferase
APASM_RS12065	COG1940	carbohydrate kinase activity
APASM_RS12070	COG0673	inositol 2-dehydrogenase activity
APASM_RS12080	COG0277	FAD linked oxidase domain protein
APASM_RS12120	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
APASM_RS12125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_RS12130	COG2205	protein histidine kinase activity
APASM_RS12145	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APASM_RS12155	COG0745	RESPONSE REGULATOR receiver
APASM_RS12165	COG0745	RESPONSE REGULATOR receiver
APASM_RS12175	COG2201	protein-glutamate methylesterase activity
APASM_RS12190	COG0835	chemotaxis
APASM_RS12195	COG2198	Histidine kinase
APASM_RS12195	COG0643	Histidine kinase
APASM_RS12195	COG0784	Response regulator, receiver
APASM_RS12215	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APASM_RS12225	COG1987	bacterial-type flagellum assembly
APASM_RS12230	COG1338	Plays a role in the flagellum-specific transport system
APASM_RS12255	COG1360	Flagellar Motor Protein
APASM_RS12260	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
APASM_RS12270	COG4786	Flagellar basal body rod
APASM_RS12290	COG0741	lytic transglycosylase activity
APASM_RS12300	COG1157	protein secretion by the type III secretion system
APASM_RS12310	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APASM_RS12315	COG1766	The M ring may be actively involved in energy transduction
APASM_RS12320	COG1677	Flagellar hook-basal body complex protein FliE
APASM_RS12340	COG1516	flagellar protein fliS
APASM_RS12365	COG1256	bacterial-type flagellum assembly
APASM_RS12365	COG4786	Flagellar basal body rod
APASM_RS12375	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
APASM_RS12380	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
APASM_RS12410	COG5002	protein histidine kinase activity
APASM_RS12420	COG0745	RESPONSE REGULATOR receiver
APASM_RS12420	COG2205	protein histidine kinase activity
APASM_RS12420	COG4191	Histidine kinase
APASM_RS12450	COG1846	Transcriptional regulator
APASM_RS12470	COG4251	negative regulation of phosphorylation
APASM_RS12495	COG1522	sequence-specific DNA binding
APASM_RS12500	COG2814	Major facilitator Superfamily
APASM_RS12530	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS12540	COG0326	Molecular chaperone. Has ATPase activity
APASM_RS12555	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS12590	COG1609	Transcriptional regulator
APASM_RS12600	COG1175	transmembrane transport
APASM_RS12605	COG0395	ABC-type sugar transport system, permease component
APASM_RS12620	COG2197	response regulator
APASM_RS12650	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APASM_RS12680	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS12705	COG0277	FAD linked oxidase domain protein
APASM_RS12750	COG1196	nuclear chromosome segregation
APASM_RS12755	COG0420	3'-5' exonuclease activity
APASM_RS12780	COG0604	alcohol dehydrogenase
APASM_RS12790	COG2124	cytochrome p450
APASM_RS12805	COG2119	membrane
APASM_RS12850	COG0747	negative chemotaxis
APASM_RS12860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APASM_RS12885	COG0745	RESPONSE REGULATOR receiver
APASM_RS12890	COG2205	protein histidine kinase activity
APASM_RS12915	COG1802	Transcriptional regulator
APASM_RS12955	COG1335	isochorismatase
APASM_RS13030	COG0477	Major facilitator Superfamily
APASM_RS13045	COG2124	cytochrome p450
APASM_RS13065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APASM_RS13075	COG1819	glycosyl
APASM_RS13080	COG1132	(ABC) transporter
APASM_RS13105	COG3795	YCII-related domain
APASM_RS13110	COG4941	Belongs to the sigma-70 factor family
APASM_RS13150	COG0714	Associated with various cellular activities
APASM_RS13155	COG3552	Protein containing von Willebrand factor type A (VWA) domain
APASM_RS13190	COG0384	phenazine biosynthesis protein PhzF
APASM_RS13205	COG3629	intracellular signal transduction
APASM_RS13205	COG3903	Transcriptional regulator
APASM_RS13250	COG0515	serine threonine protein kinase
APASM_RS13265	COG1653	transport
APASM_RS13270	COG2124	cytochrome p450
APASM_RS13280	COG2814	Major facilitator Superfamily
APASM_RS13290	COG4581	dead DEAH box helicase
APASM_RS13340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APASM_RS13355	COG0477	Major facilitator Superfamily
APASM_RS13365	COG1612	heme a metabolic process
APASM_RS13375	COG5001	Diguanylate cyclase
APASM_RS13475	COG0395	ABC-type sugar transport system, permease component
APASM_RS13495	COG1609	Transcriptional regulator
APASM_RS13505	COG1595	DNA-templated transcription, initiation
APASM_RS13565	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
APASM_RS13570	COG0477	Major facilitator Superfamily
APASM_RS13615	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS13620	COG1309	transcriptional regulator
APASM_RS13625	COG3384	dioxygenase
APASM_RS13630	COG0702	epimerase
APASM_RS13665	COG0488	(ABC) transporter
APASM_RS13680	COG0640	Transcriptional regulator
APASM_RS13685	COG0346	lactoylglutathione lyase activity
APASM_RS13710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_RS13720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APASM_RS13740	COG2205	protein histidine kinase activity
APASM_RS13750	COG1253	flavin adenine dinucleotide binding
APASM_RS13760	COG0604	alcohol dehydrogenase
APASM_RS13770	COG2080	2 iron, 2 sulfur cluster binding
APASM_RS13770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APASM_RS13810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APASM_RS13820	COG2376	Dihydroxyacetone kinase
APASM_RS13825	COG0698	ribose 5-phosphate isomerase
APASM_RS13830	COG0149	triose-phosphate isomerase activity
APASM_RS13835	COG1082	Xylose isomerase domain protein TIM barrel
APASM_RS13840	COG2084	Dehydrogenase
APASM_RS13890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APASM_RS13890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APASM_RS13900	COG1834	amidinotransferase
APASM_RS13915	COG0475	glutathione-regulated potassium exporter activity
APASM_RS13920	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APASM_RS13970	COG2197	response regulator
APASM_RS13975	COG1131	(ABC) transporter
APASM_RS13995	COG0477	Major facilitator Superfamily
APASM_RS14020	COG2267	carboxylic ester hydrolase activity
APASM_RS14030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APASM_RS14050	COG1509	lysine 2,3-aminomutase activity
APASM_RS14080	COG1136	(ABC) transporter
APASM_RS14115	COG4122	O-methyltransferase activity
APASM_RS14130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_RS14135	COG1120	ATPase activity
APASM_RS14190	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APASM_RS14205	COG1120	ATPase activity
APASM_RS14210	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_RS14215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_RS14220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APASM_RS14225	COG2375	cellular response to nickel ion
APASM_RS14230	COG3433	isochorismatase activity
APASM_RS14230	COG1535	isochorismatase
APASM_RS14235	COG3433	isochorismatase activity
APASM_RS14235	COG1535	isochorismatase
APASM_RS14240	COG1021	2,3-dihydroxybenzoate-AMP ligase
APASM_RS14245	COG1169	isochorismate synthase
APASM_RS14250	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS14260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_RS14265	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
APASM_RS14275	COG3655	Transcriptional regulator
APASM_RS14290	COG4585	Histidine kinase
APASM_RS14295	COG2197	response regulator
APASM_RS14310	COG0148	phosphopyruvate hydratase activity
APASM_RS14325	COG4152	abc transporter atp-binding protein
APASM_RS14330	COG1668	transmembrane transport
APASM_RS14380	COG0477	Major facilitator Superfamily
APASM_RS14390	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
APASM_RS14395	COG2197	response regulator
APASM_RS14405	COG1136	(ABC) transporter
APASM_RS14405	COG0577	efflux transmembrane transporter activity
APASM_RS14475	COG0456	acetyltransferase
APASM_RS14480	COG1309	transcriptional regulator
APASM_RS14485	COG1132	(ABC) transporter
APASM_RS14500	COG0738	Major facilitator superfamily
APASM_RS14510	COG0583	DNA-binding transcription factor activity
APASM_RS14515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APASM_RS14525	COG1012	belongs to the aldehyde dehydrogenase family
APASM_RS14550	COG2409	Drug exporters of the RND superfamily
APASM_RS14655	COG2197	response regulator
APASM_RS14720	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
APASM_RS14725	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APASM_RS14740	COG1131	(ABC) transporter
APASM_RS14750	COG0604	alcohol dehydrogenase
APASM_RS14750	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS14750	COG3321	synthase
APASM_RS14780	COG1653	transport
APASM_RS14790	COG3833	ABC-type maltose transport systems, permease component
APASM_RS14805	COG3507	Belongs to the glycosyl hydrolase 43 family
APASM_RS14815	COG0596	Alpha beta hydrolase
APASM_RS14830	COG2197	response regulator
APASM_RS14850	COG0028	Belongs to the TPP enzyme family
APASM_RS14855	COG1473	amidohydrolase
APASM_RS14860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_RS14875	COG1177	transmembrane transport
APASM_RS14880	COG1176	ABC-type spermidine putrescine transport system, permease component I
APASM_RS14885	COG3842	ATPase activity
APASM_RS14895	COG4221	oxidoreductase activity
APASM_RS14915	COG1309	transcriptional regulator
APASM_RS14965	COG3209	COG3209 Rhs family protein
APASM_RS14985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_RS14990	COG1120	ATPase activity
APASM_RS15025	COG0135	phosphoribosylanthranilate isomerase activity
APASM_RS15065	COG3629	intracellular signal transduction
APASM_RS15065	COG3903	Transcriptional regulator
APASM_RS15080	COG2076	Multidrug Resistance protein
APASM_RS15125	COG0642	Histidine kinase
APASM_RS15135	COG0402	S-adenosylhomocysteine deaminase activity
APASM_RS15140	COG1309	transcriptional regulator
APASM_RS15145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APASM_RS15190	COG3831	ATPase activity
APASM_RS15195	COG4251	negative regulation of phosphorylation
APASM_RS15205	COG0784	Response regulator, receiver
APASM_RS15220	COG1733	regulation of RNA biosynthetic process
APASM_RS15225	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS15235	COG0395	ABC-type sugar transport system, permease component
APASM_RS15255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APASM_RS15270	COG3903	Transcriptional regulator
APASM_RS15270	COG3629	intracellular signal transduction
APASM_RS15310	COG1222	aaa ATPase
APASM_RS15420	COG3629	intracellular signal transduction
APASM_RS15420	COG3903	Transcriptional regulator
APASM_RS15465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APASM_RS15480	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
APASM_RS15510	COG0673	inositol 2-dehydrogenase activity
APASM_RS15525	COG0494	nUDIX hydrolase
APASM_RS15530	COG1309	transcriptional regulator
APASM_RS15560	COG2182	Extracellular solute-binding protein
APASM_RS15565	COG1175	transmembrane transport
APASM_RS15570	COG0395	ABC-type sugar transport system, permease component
APASM_RS15575	COG1501	Belongs to the glycosyl hydrolase 31 family
APASM_RS15585	COG1609	Transcriptional regulator
APASM_RS15615	COG4106	trans-aconitate 2-methyltransferase activity
APASM_RS15635	COG2318	DinB family
APASM_RS15640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APASM_RS15655	COG1309	transcriptional regulator
APASM_RS15665	COG0789	Transcriptional regulator
APASM_RS15670	COG2197	response regulator
APASM_RS15680	COG0577	efflux transmembrane transporter activity
APASM_RS15680	COG1136	(ABC) transporter
APASM_RS15685	COG1136	(ABC) transporter
APASM_RS15685	COG0577	efflux transmembrane transporter activity
APASM_RS15695	COG0366	Alpha amylase catalytic
APASM_RS15730	COG2375	cellular response to nickel ion
APASM_RS15735	COG3903	Transcriptional regulator
APASM_RS15735	COG3629	intracellular signal transduction
APASM_RS15765	COG3831	ATPase activity
APASM_RS15800	COG0483	inositol monophosphate 1-phosphatase activity
APASM_RS15805	COG1132	(ABC) transporter
APASM_RS15810	COG1132	(ABC) transporter
APASM_RS15860	COG1556	Lactate utilization protein
APASM_RS15865	COG1139	Iron-sulfur cluster binding protein
APASM_RS15870	COG0247	lactate metabolic process
APASM_RS15875	COG2188	Transcriptional regulator
APASM_RS15890	COG1129	ABC transporter
APASM_RS15900	COG1172	Belongs to the binding-protein-dependent transport system permease family
APASM_RS15915	COG3347	Dehydrogenase
APASM_RS15915	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS15920	COG1070	Carbohydrate kinase
APASM_RS15930	COG0402	S-adenosylhomocysteine deaminase activity
APASM_RS15940	COG0583	DNA-binding transcription factor activity
APASM_RS15950	COG3851	Histidine kinase
APASM_RS15960	COG1595	DNA-templated transcription, initiation
APASM_RS15975	COG2124	cytochrome p450
APASM_RS16015	COG0601	transmembrane transport
APASM_RS16020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APASM_RS16025	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APASM_RS16035	COG0367	asparagine synthase
APASM_RS16055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APASM_RS16060	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APASM_RS16065	COG1012	belongs to the aldehyde dehydrogenase family
APASM_RS16070	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APASM_RS16140	COG2814	Major facilitator Superfamily
APASM_RS16185	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
APASM_RS16190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APASM_RS16205	COG3345	alpha-galactosidase
APASM_RS16220	COG0644	oxidoreductase
APASM_RS16225	COG0156	8-amino-7-oxononanoate synthase activity
APASM_RS16235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APASM_RS16245	COG3903	Transcriptional regulator
APASM_RS16245	COG3629	intracellular signal transduction
APASM_RS16255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APASM_RS16310	COG0656	L-ascorbic acid biosynthetic process
APASM_RS16315	COG0583	DNA-binding transcription factor activity
APASM_RS16330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APASM_RS16340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APASM_RS16345	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APASM_RS16380	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS16395	COG1063	alcohol dehydrogenase
APASM_RS16405	COG0659	secondary active sulfate transmembrane transporter activity
APASM_RS16445	COG1408	metallophosphoesterase
APASM_RS16465	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APASM_RS16465	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APASM_RS16470	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APASM_RS16480	COG2856	Zn peptidase
APASM_RS16490	COG2409	Drug exporters of the RND superfamily
APASM_RS16505	COG1024	Enoyl-CoA hydratase
APASM_RS16540	COG1309	transcriptional regulator
APASM_RS16550	COG1132	(ABC) transporter
APASM_RS16555	COG0475	glutathione-regulated potassium exporter activity
APASM_RS16580	COG3321	synthase
APASM_RS16580	COG0604	alcohol dehydrogenase
APASM_RS16590	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
APASM_RS16605	COG1250	3-hydroxyacyl-CoA dehydrogenase
APASM_RS16610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APASM_RS16640	COG3795	YCII-related domain
APASM_RS16660	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APASM_RS16670	COG3321	synthase
APASM_RS16670	COG0604	alcohol dehydrogenase
APASM_RS16710	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS16725	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
APASM_RS16725	COG2124	cytochrome p450
APASM_RS16730	COG2124	cytochrome p450
APASM_RS16730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
APASM_RS16780	COG3507	Belongs to the glycosyl hydrolase 43 family
APASM_RS16805	COG4585	Histidine kinase
APASM_RS16810	COG2197	response regulator
APASM_RS16840	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS16845	COG0667	Aldo Keto reductase
APASM_RS16865	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
APASM_RS16870	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
APASM_RS16960	COG1250	3-hydroxyacyl-CoA dehydrogenase
APASM_RS17000	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APASM_RS17015	COG0546	phosphoglycolate phosphatase activity
APASM_RS17020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APASM_RS17045	COG0604	alcohol dehydrogenase
APASM_RS17045	COG3321	synthase
APASM_RS17060	COG3321	synthase
APASM_RS17060	COG0604	alcohol dehydrogenase
APASM_RS17065	COG3321	synthase
APASM_RS17065	COG0604	alcohol dehydrogenase
APASM_RS17110	COG3509	depolymerase
APASM_RS17110	COG3693	PFAM glycoside hydrolase, family 10
APASM_RS17125	COG1609	Transcriptional regulator
APASM_RS17135	COG0454	-acetyltransferase
APASM_RS17135	COG0456	acetyltransferase
APASM_RS17145	COG1335	isochorismatase
APASM_RS17165	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS17185	COG4585	Histidine kinase
APASM_RS17200	COG1073	alpha beta
APASM_RS17215	COG0714	Associated with various cellular activities
APASM_RS17280	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS17305	COG1609	Transcriptional regulator
APASM_RS17315	COG1733	regulation of RNA biosynthetic process
APASM_RS17340	COG2267	carboxylic ester hydrolase activity
APASM_RS17370	COG2261	transglycosylase associated protein
APASM_RS17380	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
APASM_RS17400	COG2197	response regulator
APASM_RS17415	COG1064	alcohol dehydrogenase
APASM_RS17430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APASM_RS17440	COG0667	Aldo Keto reductase
APASM_RS17455	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
APASM_RS17460	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APASM_RS17495	COG0028	Belongs to the TPP enzyme family
APASM_RS17515	COG0583	DNA-binding transcription factor activity
APASM_RS17530	COG1233	COG1233 Phytoene dehydrogenase and related
APASM_RS17555	COG2249	NAD(P)H dehydrogenase (quinone) activity
APASM_RS17585	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
APASM_RS17590	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
APASM_RS17600	COG1228	amidohydrolase
APASM_RS17605	COG1607	acyl-coa hydrolase
APASM_RS17625	COG0463	Glycosyl transferase, family 2
APASM_RS17655	COG1435	thymidine kinase activity
APASM_RS17670	COG2270	Major facilitator Superfamily
APASM_RS17685	COG3706	GGDEF domain
APASM_RS17700	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
APASM_RS17730	COG0640	Transcriptional regulator
APASM_RS17735	COG0798	PFAM Bile acid sodium symporter
APASM_RS17740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APASM_RS17795	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS17815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APASM_RS17820	COG1349	DNA-binding transcription factor activity
APASM_RS17830	COG0494	nUDIX hydrolase
APASM_RS17840	COG2176	DNA-directed DNA polymerase activity
APASM_RS17840	COG5002	protein histidine kinase activity
APASM_RS17880	COG1619	proteins homologs of microcin C7 resistance protein MccF
APASM_RS17885	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS17910	COG1011	Hydrolase
APASM_RS17920	COG1960	acyl-CoA dehydrogenase activity
APASM_RS17930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APASM_RS17940	COG0747	negative chemotaxis
APASM_RS17945	COG2362	D-Aminopeptidase
APASM_RS17950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APASM_RS17960	COG1609	Transcriptional regulator
APASM_RS17980	COG0395	ABC-type sugar transport system, permease component
APASM_RS17985	COG4974	Belongs to the 'phage' integrase family
APASM_RS18045	COG0667	Aldo Keto reductase
APASM_RS18085	COG2755	lipolytic protein G-D-S-L family
APASM_RS18120	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APASM_RS18130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APASM_RS18140	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APASM_RS18150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APASM_RS18165	COG1846	Transcriptional regulator
APASM_RS18190	COG2130	NADP-dependent
APASM_RS18200	COG1643	Atp-dependent helicase
APASM_RS18220	COG1968	undecaprenyl-diphosphatase activity
APASM_RS18225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_RS18230	COG0667	Aldo Keto reductase
APASM_RS18270	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APASM_RS18280	COG2909	trisaccharide binding
APASM_RS18285	COG1414	Transcriptional regulator
APASM_RS18295	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
APASM_RS18355	COG2814	Major facilitator Superfamily
APASM_RS18385	COG1216	Glycosyl transferase, family 2
APASM_RS18385	COG0438	transferase activity, transferring glycosyl groups
APASM_RS18400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APASM_RS18425	COG1316	TRANSCRIPTIONal
APASM_RS18435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_RS18455	COG1404	Belongs to the peptidase S8 family
APASM_RS18460	COG1309	transcriptional regulator
APASM_RS18480	COG4552	Acetyltransferase involved in intracellular survival and related
APASM_RS18485	COG3507	Belongs to the glycosyl hydrolase 43 family
APASM_RS18495	COG3629	intracellular signal transduction
APASM_RS18495	COG3903	Transcriptional regulator
APASM_RS18510	COG2197	response regulator
APASM_RS18520	COG2124	cytochrome p450
APASM_RS18545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APASM_RS18550	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APASM_RS18555	COG3321	synthase
APASM_RS18555	COG0604	alcohol dehydrogenase
APASM_RS18555	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS18585	COG0310	cobalt ion transport
APASM_RS18620	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
APASM_RS18620	COG2508	Transcriptional regulator
APASM_RS18625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APASM_RS18630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APASM_RS18645	COG2124	cytochrome p450
APASM_RS18660	COG1132	(ABC) transporter
APASM_RS18710	COG1136	(ABC) transporter
APASM_RS18735	COG1012	belongs to the aldehyde dehydrogenase family
APASM_RS18775	COG0110	maltose O-acetyltransferase activity
APASM_RS18805	COG2226	methyltransferase
APASM_RS18825	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APASM_RS18865	COG1132	(ABC) transporter
APASM_RS18935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_RS18945	COG1309	transcriptional regulator
APASM_RS18965	COG3030	protein affecting phage T7 exclusion by the F plasmid
APASM_RS19010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APASM_RS19040	COG3395	kinase activity
APASM_RS19045	COG0235	Class ii aldolase
APASM_RS19050	COG1349	DNA-binding transcription factor activity
APASM_RS19065	COG0387	Pfam Sodium calcium exchanger
APASM_RS19070	COG1366	Belongs to the anti-sigma-factor antagonist family
APASM_RS19070	COG2172	sigma factor antagonist activity
APASM_RS19070	COG2208	phosphoserine phosphatase activity
APASM_RS19075	COG3629	intracellular signal transduction
APASM_RS19075	COG3903	Transcriptional regulator
APASM_RS19090	COG2205	protein histidine kinase activity
APASM_RS19090	COG2198	Histidine kinase
APASM_RS19090	COG0784	Response regulator, receiver
APASM_RS19090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APASM_RS19100	COG2172	sigma factor antagonist activity
APASM_RS19105	COG1366	Belongs to the anti-sigma-factor antagonist family
APASM_RS19110	COG1366	Belongs to the anti-sigma-factor antagonist family
APASM_RS19125	COG2072	flavoprotein involved in K transport
APASM_RS19215	COG0789	Transcriptional regulator
APASM_RS19240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APASM_RS19285	COG3210	domain, Protein
APASM_RS19340	COG4257	antibiotic catabolic process
APASM_RS19375	COG3345	alpha-galactosidase
APASM_RS19395	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APASM_RS19415	COG1959	2 iron, 2 sulfur cluster binding
APASM_RS19420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APASM_RS19420	COG1017	nitric oxide dioxygenase activity
APASM_RS19445	COG0142	geranyltranstransferase activity
APASM_RS19465	COG4106	trans-aconitate 2-methyltransferase activity
APASM_RS19490	COG0667	Aldo Keto reductase
APASM_RS19525	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APASM_RS19530	COG1021	2,3-dihydroxybenzoate-AMP ligase
APASM_RS19540	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
APASM_RS19545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APASM_RS19560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APASM_RS19585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APASM_RS19595	COG0673	inositol 2-dehydrogenase activity
APASM_RS19625	COG1309	transcriptional regulator
APASM_RS19640	COG3537	Alpha-1,2-mannosidase
APASM_RS19650	COG0596	Alpha beta hydrolase
APASM_RS19675	COG2814	Major facilitator Superfamily
APASM_RS19680	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APASM_RS19750	COG2755	lipolytic protein G-D-S-L family
APASM_RS19760	COG0745	RESPONSE REGULATOR receiver
APASM_RS19775	COG0582	viral genome integration into host DNA
APASM_RS19820	COG0602	queuosine metabolic process
APASM_RS19825	COG0720	synthase
APASM_RS19850	COG0438	transferase activity, transferring glycosyl groups
APASM_RS19860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APASM_RS19870	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APASM_RS19880	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APASM_RS19935	COG0134	indole-3-glycerol-phosphate synthase activity
APASM_RS19960	COG2319	Wd-40 repeat
APASM_RS19960	COG4249	Peptidase C14 caspase catalytic subunit p20
APASM_RS20135	COG2175	clavaminate synthase activity
APASM_RS20165	COG0702	epimerase
APASM_RS20170	COG0583	DNA-binding transcription factor activity
APASM_RS20185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APASM_RS20185	COG0604	alcohol dehydrogenase
APASM_RS20185	COG3321	synthase
APASM_RS20185	COG4221	oxidoreductase activity
APASM_RS20225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_RS20240	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
APASM_RS20245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_RS20290	COG2192	nodulation
APASM_RS20300	COG3940	Belongs to the glycosyl hydrolase 43 family
APASM_RS20330	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
APASM_RS20375	COG2197	response regulator
APASM_RS20385	COG1309	transcriptional regulator
APASM_RS20430	COG3509	depolymerase
APASM_RS20460	COG1064	alcohol dehydrogenase
APASM_RS20510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APASM_RS20515	COG1309	transcriptional regulator
APASM_RS20520	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS20535	COG3226	Transcriptional regulator
APASM_RS20540	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APASM_RS20555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APASM_RS20580	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS20595	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS20600	COG0435	Glutathione S-transferase
APASM_RS20630	COG0596	Alpha beta hydrolase
APASM_RS20635	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
APASM_RS20660	COG2197	response regulator
APASM_RS20715	COG0673	inositol 2-dehydrogenase activity
APASM_RS20730	COG4335	DNA alkylation repair
APASM_RS20735	COG0596	Alpha beta hydrolase
APASM_RS20740	COG0745	RESPONSE REGULATOR receiver
APASM_RS20745	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APASM_RS20775	COG0604	alcohol dehydrogenase
APASM_RS20775	COG3321	synthase
APASM_RS20790	COG1472	Belongs to the glycosyl hydrolase 3 family
APASM_RS20820	COG0515	serine threonine protein kinase
APASM_RS20845	COG0492	ferredoxin-NADP+ reductase activity
APASM_RS20860	COG0475	glutathione-regulated potassium exporter activity
APASM_RS20925	COG1136	(ABC) transporter
APASM_RS20935	COG2197	response regulator
APASM_RS20940	COG3851	Histidine kinase
APASM_RS20995	COG3284	Transcriptional regulator
APASM_RS21005	COG1309	transcriptional regulator
APASM_RS21020	COG5002	protein histidine kinase activity
APASM_RS21025	COG0745	RESPONSE REGULATOR receiver
APASM_RS21040	COG0577	efflux transmembrane transporter activity
APASM_RS21065	COG2345	Transcriptional regulator
APASM_RS21100	COG1960	acyl-CoA dehydrogenase activity
APASM_RS21110	COG2814	Major facilitator Superfamily
APASM_RS21140	COG0596	Alpha beta hydrolase
APASM_RS21165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APASM_RS21175	COG0300	oxidoreductase activity
APASM_RS21180	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
APASM_RS21190	COG2124	cytochrome p450
APASM_RS21200	COG2207	Transcriptional regulator
APASM_RS21255	COG0318	PFAM AMP-dependent synthetase and ligase
APASM_RS21260	COG1024	Enoyl-CoA hydratase
APASM_RS21275	COG1917	Cupin 2, conserved barrel domain protein
APASM_RS21275	COG4977	sequence-specific DNA binding
APASM_RS21315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APASM_RS21325	COG1609	Transcriptional regulator
APASM_RS21335	COG4948	Mandelate Racemase Muconate Lactonizing
APASM_RS21360	COG2205	protein histidine kinase activity
APASM_RS21365	COG0745	RESPONSE REGULATOR receiver
APASM_RS21415	COG2267	carboxylic ester hydrolase activity
APASM_RS21470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APASM_RS21480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APASM_RS21500	COG1414	Transcriptional regulator
APASM_RS21505	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APASM_RS21540	COG3340	Belongs to the peptidase S51 family
APASM_RS21565	COG0604	alcohol dehydrogenase
APASM_RS21565	COG3321	synthase
APASM_RS21590	COG3903	Transcriptional regulator
APASM_RS21590	COG3629	intracellular signal transduction
APASM_RS21595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
APASM_RS21605	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APASM_RS21615	COG4221	oxidoreductase activity
APASM_RS21650	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
APASM_RS21655	COG1404	Belongs to the peptidase S8 family
APASM_RS21660	COG1404	Belongs to the peptidase S8 family
APASM_RS21665	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
APASM_RS21665	COG4932	domain protein
APASM_RS21665	COG3266	domain, Protein
APASM_RS21700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APASM_RS21705	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APASM_RS21715	COG3486	L-lysine 6-monooxygenase (NADPH) activity
APASM_RS21725	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APASM_RS21725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APASM_RS21735	COG0697	spore germination
APASM_RS21740	COG0644	oxidoreductase
APASM_RS21750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APASM_RS21760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APASM_RS21810	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
APASM_RS21820	COG0659	secondary active sulfate transmembrane transporter activity
APASM_RS21835	COG2255	four-way junction helicase activity
APASM_RS21870	COG3467	pyridoxamine 5'-phosphate
APASM_RS21875	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
APASM_RS21880	COG2124	cytochrome p450
APASM_RS21890	COG0726	polysaccharide deacetylase
APASM_RS21895	COG0439	Biotin carboxylase
APASM_RS21900	COG0395	ABC-type sugar transport system, permease component
APASM_RS21905	COG1175	transmembrane transport
APASM_RS21910	COG2182	Extracellular solute-binding protein
APASM_RS21920	COG0667	Aldo Keto reductase
APASM_RS21940	COG0300	oxidoreductase activity
APASM_RS21990	COG0110	maltose O-acetyltransferase activity
APASM_RS22005	COG1181	Belongs to the D-alanine--D-alanine ligase family
APASM_RS22020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APASM_RS22025	COG2197	response regulator
APASM_RS22030	COG3850	Histidine kinase
APASM_RS22045	COG3831	ATPase activity
APASM_RS22120	COG0534	Mate efflux family protein
APASM_RS22135	COG0640	Transcriptional regulator
APASM_RS22150	COG0640	Transcriptional regulator
APASM_RS22155	COG0672	)-iron permease
APASM_RS22165	COG2837	iron assimilation
APASM_RS22180	COG0596	Alpha beta hydrolase
APASM_RS22185	COG1120	ATPase activity
APASM_RS22190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_RS22195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_RS22220	COG1982	Orn Lys Arg decarboxylase major
APASM_RS22255	COG0277	FAD linked oxidase domain protein
APASM_RS22275	COG0583	DNA-binding transcription factor activity
APASM_RS22280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_RS22285	COG1960	acyl-CoA dehydrogenase activity
APASM_RS22330	COG4172	Belongs to the ABC transporter superfamily
APASM_RS22375	COG0784	Response regulator, receiver
APASM_RS22395	COG1522	sequence-specific DNA binding
APASM_RS22405	COG0861	Integral membrane protein TerC family
APASM_RS22410	COG1309	transcriptional regulator
APASM_RS22420	COG2807	transmembrane transport
APASM_RS22430	COG0475	glutathione-regulated potassium exporter activity
APASM_RS22440	COG2814	Major facilitator Superfamily
APASM_RS22490	COG2986	histidine ammonia-lyase
APASM_RS22510	COG3321	synthase
APASM_RS22510	COG0604	alcohol dehydrogenase
APASM_RS22565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_RS22580	COG1960	acyl-CoA dehydrogenase activity
APASM_RS22595	COG0183	Belongs to the thiolase family
APASM_RS22600	COG1250	3-hydroxyacyl-CoA dehydrogenase
APASM_RS22600	COG1024	Enoyl-CoA hydratase
APASM_RS22620	COG2010	Cytochrome c
APASM_RS22620	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APASM_RS22625	COG2080	2 iron, 2 sulfur cluster binding
APASM_RS22635	COG1201	RNA secondary structure unwinding
APASM_RS22650	COG0556	nucleotide-excision repair
APASM_RS22655	COG0142	geranyltranstransferase activity
APASM_RS22660	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
APASM_RS22665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APASM_RS22675	COG2175	clavaminate synthase activity
APASM_RS22690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APASM_RS22720	COG2340	Cysteine-rich secretory protein family
APASM_RS22735	COG1309	transcriptional regulator
APASM_RS22750	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS22755	COG1309	transcriptional regulator
APASM_RS22760	COG0789	Transcriptional regulator
APASM_RS22780	COG3831	ATPase activity
APASM_RS22795	COG0438	transferase activity, transferring glycosyl groups
APASM_RS22835	COG0254	rRNA binding
APASM_RS22845	COG0753	catalase activity
APASM_RS22850	COG0519	Catalyzes the synthesis of GMP from XMP
APASM_RS22850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APASM_RS22855	COG2258	MOSC domain
APASM_RS22875	COG0604	alcohol dehydrogenase
APASM_RS22885	COG0604	alcohol dehydrogenase
APASM_RS22925	COG2197	response regulator
APASM_RS22930	COG4585	Histidine kinase
APASM_RS22950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APASM_RS22955	COG1121	(ABC) transporter
APASM_RS22960	COG0803	Belongs to the bacterial solute-binding protein 9 family
APASM_RS22970	COG0604	alcohol dehydrogenase
APASM_RS22970	COG3321	synthase
APASM_RS22970	COG3321	synthase
APASM_RS22970	COG0604	alcohol dehydrogenase
APASM_RS22980	COG0604	alcohol dehydrogenase
APASM_RS22980	COG3321	synthase
APASM_RS23005	COG0604	alcohol dehydrogenase
APASM_RS23005	COG0604	alcohol dehydrogenase
APASM_RS23005	COG3321	synthase
APASM_RS23005	COG3321	synthase
APASM_RS23020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APASM_RS23050	COG3629	intracellular signal transduction
APASM_RS23075	COG0730	response to heat
APASM_RS23090	COG4221	oxidoreductase activity
APASM_RS23135	COG1022	Amp-dependent synthetase and ligase
APASM_RS23150	COG1309	transcriptional regulator
APASM_RS23155	COG0778	Nitroreductase
APASM_RS23185	COG1063	alcohol dehydrogenase
APASM_RS23210	COG1509	lysine 2,3-aminomutase activity
APASM_RS23220	COG0644	oxidoreductase
APASM_RS23225	COG3486	L-lysine 6-monooxygenase (NADPH) activity
APASM_RS23230	COG2808	Putative FMN-binding domain
APASM_RS23285	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
APASM_RS23290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APASM_RS23295	COG0165	Argininosuccinate lyase
APASM_RS23315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APASM_RS23320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APASM_RS23330	COG3973	AAA domain
APASM_RS23335	COG2409	Drug exporters of the RND superfamily
APASM_RS23345	COG2197	response regulator
APASM_RS23355	COG2205	protein histidine kinase activity
APASM_RS23360	COG0745	RESPONSE REGULATOR receiver
APASM_RS23415	COG3209	COG3209 Rhs family protein
APASM_RS23465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APASM_RS23595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APASM_RS23595	COG3321	synthase
APASM_RS23595	COG0318	PFAM AMP-dependent synthetase and ligase
APASM_RS23595	COG0300	oxidoreductase activity
APASM_RS23595	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS23635	COG2124	cytochrome p450
APASM_RS23645	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
APASM_RS23680	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
APASM_RS23705	COG1278	Cold shock
APASM_RS23775	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APASM_RS23775	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APASM_RS23855	COG3903	Transcriptional regulator
APASM_RS23855	COG3629	intracellular signal transduction
APASM_RS23865	COG2124	cytochrome p450
APASM_RS23885	COG0300	oxidoreductase activity
APASM_RS23900	COG2272	Belongs to the type-B carboxylesterase lipase family
APASM_RS23910	COG1609	Transcriptional regulator
APASM_RS23920	COG1175	transmembrane transport
APASM_RS23925	COG0395	ABC-type sugar transport system, permease component
APASM_RS23930	COG1472	Belongs to the glycosyl hydrolase 3 family
APASM_RS23965	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS23980	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS24010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APASM_RS24025	COG0583	DNA-binding transcription factor activity
APASM_RS24030	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APASM_RS24035	COG3250	beta-galactosidase activity
APASM_RS24045	COG2909	trisaccharide binding
APASM_RS24050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APASM_RS24050	COG4221	oxidoreductase activity
APASM_RS24050	COG0604	alcohol dehydrogenase
APASM_RS24050	COG3321	synthase
APASM_RS24075	COG0438	transferase activity, transferring glycosyl groups
APASM_RS24115	COG1022	Amp-dependent synthetase and ligase
APASM_RS24125	COG0657	acetylesterase activity
APASM_RS24130	COG0022	dehydrogenase e1 component
APASM_RS24130	COG0508	dehydrogenase complex catalyzes the overall conversion of
APASM_RS24135	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APASM_RS24155	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS24185	COG4974	Belongs to the 'phage' integrase family
APASM_RS24410	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APASM_RS24445	COG2755	lipolytic protein G-D-S-L family
APASM_RS24480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_RS24495	COG2755	lipolytic protein G-D-S-L family
APASM_RS24530	COG1309	transcriptional regulator
APASM_RS24535	COG0318	PFAM AMP-dependent synthetase and ligase
APASM_RS24540	COG1012	belongs to the aldehyde dehydrogenase family
APASM_RS24650	COG0702	epimerase
APASM_RS24665	COG1733	regulation of RNA biosynthetic process
APASM_RS24700	COG0006	proline dipeptidase activity
APASM_RS24715	COG0444	Belongs to the ABC transporter superfamily
APASM_RS24730	COG0747	negative chemotaxis
APASM_RS24735	COG1802	Transcriptional regulator
APASM_RS24745	COG3938	Belongs to the proline racemase family
APASM_RS24750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APASM_RS24765	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APASM_RS24775	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
APASM_RS24780	COG1609	Transcriptional regulator
APASM_RS24790	COG0402	S-adenosylhomocysteine deaminase activity
APASM_RS24820	COG1131	(ABC) transporter
APASM_RS24830	COG1595	DNA-templated transcription, initiation
APASM_RS24930	COG0443	Heat shock 70 kDa protein
APASM_RS24950	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
APASM_RS24985	COG1121	(ABC) transporter
APASM_RS24990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APASM_RS25000	COG0523	cobalamin synthesis protein
APASM_RS25050	COG1120	ATPase activity
APASM_RS25055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_RS25075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APASM_RS25095	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS25105	COG1309	transcriptional regulator
APASM_RS25110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APASM_RS25115	COG2391	methyltransferase activity
APASM_RS25135	COG0477	Major facilitator Superfamily
APASM_RS25140	COG1309	transcriptional regulator
APASM_RS25190	COG2018	Roadblock/LC7 domain
APASM_RS25205	COG0673	inositol 2-dehydrogenase activity
APASM_RS25220	COG1929	Belongs to the glycerate kinase type-1 family
APASM_RS25240	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APASM_RS25280	COG2124	cytochrome p450
APASM_RS25290	COG1216	Glycosyl transferase, family 2
APASM_RS25300	COG0702	epimerase
APASM_RS25315	COG1819	glycosyl
APASM_RS25330	COG1819	glycosyl
APASM_RS25340	COG0515	serine threonine protein kinase
APASM_RS25355	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APASM_RS25360	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS25380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APASM_RS25385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APASM_RS25390	COG1012	belongs to the aldehyde dehydrogenase family
APASM_RS25400	COG0318	PFAM AMP-dependent synthetase and ligase
APASM_RS25405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APASM_RS25410	COG1132	(ABC) transporter
APASM_RS25415	COG1309	transcriptional regulator
APASM_RS25430	COG3386	PFAM SMP-30 Gluconolaconase
APASM_RS25435	COG2072	flavoprotein involved in K transport
APASM_RS25455	COG1472	Belongs to the glycosyl hydrolase 3 family
APASM_RS25485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APASM_RS25490	COG0494	nUDIX hydrolase
APASM_RS25500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APASM_RS25510	COG1414	Transcriptional regulator
APASM_RS25515	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
APASM_RS25525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APASM_RS25535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APASM_RS25545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APASM_RS25555	COG0583	DNA-binding transcription factor activity
APASM_RS25570	COG1902	pentaerythritol trinitrate reductase activity
APASM_RS25605	COG1802	Transcriptional regulator
APASM_RS25615	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_RS25620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_RS25640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_RS25685	COG2022	thiamine diphosphate biosynthetic process
APASM_RS25700	COG2770	Histidine kinase
APASM_RS25700	COG2208	phosphoserine phosphatase activity
APASM_RS25710	COG2365	Tyrosine phosphatase family
APASM_RS25720	COG2755	lipolytic protein G-D-S-L family
APASM_RS25725	COG3835	regulator
APASM_RS25755	COG1929	Belongs to the glycerate kinase type-1 family
APASM_RS25765	COG2205	protein histidine kinase activity
APASM_RS25770	COG0745	RESPONSE REGULATOR receiver
APASM_RS25785	COG0477	Major facilitator Superfamily
APASM_RS25795	COG0583	DNA-binding transcription factor activity
APASM_RS25810	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
APASM_RS25830	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
APASM_RS25880	COG0463	Glycosyl transferase, family 2
APASM_RS25895	COG0438	transferase activity, transferring glycosyl groups
APASM_RS25925	COG1472	Belongs to the glycosyl hydrolase 3 family
APASM_RS25935	COG2267	carboxylic ester hydrolase activity
APASM_RS25940	COG3693	PFAM glycoside hydrolase, family 10
APASM_RS25955	COG0500	methyltransferase
APASM_RS25975	COG2409	Drug exporters of the RND superfamily
APASM_RS25995	COG1253	flavin adenine dinucleotide binding
APASM_RS26025	COG0009	L-threonylcarbamoyladenylate synthase
APASM_RS26080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APASM_RS26085	COG0508	dehydrogenase complex catalyzes the overall conversion of
APASM_RS26100	COG1522	sequence-specific DNA binding
APASM_RS26105	COG2340	Cysteine-rich secretory protein family
APASM_RS26110	COG2205	protein histidine kinase activity
APASM_RS26165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APASM_RS26170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APASM_RS26175	COG0142	geranyltranstransferase activity
APASM_RS26185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APASM_RS26205	COG0463	Glycosyl transferase, family 2
APASM_RS26210	COG1064	alcohol dehydrogenase
APASM_RS26215	COG1309	transcriptional regulator
APASM_RS26225	COG2855	membrane
APASM_RS26240	COG4251	negative regulation of phosphorylation
APASM_RS26245	COG0784	Response regulator, receiver
APASM_RS26275	COG3973	AAA domain
APASM_RS26290	COG1309	transcriptional regulator
APASM_RS26295	COG0300	oxidoreductase activity
APASM_RS26305	COG0823	Involved in the tonB-independent uptake of proteins
APASM_RS26325	COG3973	AAA domain
APASM_RS26330	COG1120	ATPase activity
APASM_RS26335	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_RS26340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_RS26350	COG1063	alcohol dehydrogenase
APASM_RS26355	COG0477	Major facilitator Superfamily
APASM_RS26360	COG0246	Mannitol dehydrogenase
APASM_RS26395	COG4607	ABC-type enterochelin transport system periplasmic component
APASM_RS26400	COG3486	L-lysine 6-monooxygenase (NADPH) activity
APASM_RS26405	COG1132	(ABC) transporter
APASM_RS26410	COG1132	(ABC) transporter
APASM_RS26415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APASM_RS26465	COG1414	Transcriptional regulator
APASM_RS26470	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APASM_RS26480	COG2267	carboxylic ester hydrolase activity
APASM_RS26485	COG3485	protocatechuate 3,4-dioxygenase
APASM_RS26490	COG3485	protocatechuate 3,4-dioxygenase
APASM_RS26495	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
APASM_RS26500	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
APASM_RS26515	COG2208	phosphoserine phosphatase activity
APASM_RS26515	COG2770	Histidine kinase
APASM_RS26520	COG5002	protein histidine kinase activity
APASM_RS26520	COG0784	Response regulator, receiver
APASM_RS26535	COG0248	Ppx GppA phosphatase
APASM_RS26555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_RS26565	COG1609	Transcriptional regulator
APASM_RS26570	COG1619	proteins homologs of microcin C7 resistance protein MccF
APASM_RS26575	COG0300	oxidoreductase activity
APASM_RS26580	COG1309	transcriptional regulator
APASM_RS26640	COG1609	Transcriptional regulator
APASM_RS26655	COG0739	heme binding
APASM_RS26660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APASM_RS26665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APASM_RS26675	COG0596	Alpha beta hydrolase
APASM_RS26690	COG0583	DNA-binding transcription factor activity
APASM_RS26700	COG1349	DNA-binding transcription factor activity
APASM_RS26705	COG4821	SIS domain
APASM_RS26710	COG1132	(ABC) transporter
APASM_RS26715	COG1024	Enoyl-CoA hydratase
APASM_RS26725	COG0488	(ABC) transporter
APASM_RS26730	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS26765	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APASM_RS26795	COG3706	GGDEF domain
APASM_RS26810	COG2151	metal-sulfur cluster biosynthetic enzyme
APASM_RS26815	COG0822	iron-sulfur transferase activity
APASM_RS26825	COG0396	ATPase activity
APASM_RS26865	COG1752	Esterase of the alpha-beta hydrolase superfamily
APASM_RS26870	COG0438	transferase activity, transferring glycosyl groups
APASM_RS26880	COG1131	(ABC) transporter
APASM_RS26915	COG1510	regulation of RNA biosynthetic process
APASM_RS26925	COG2018	Roadblock/LC7 domain
APASM_RS26935	COG5002	protein histidine kinase activity
APASM_RS26945	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APASM_RS27005	COG0109	protoheme IX farnesyltransferase activity
APASM_RS27015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APASM_RS27020	COG0166	Belongs to the GPI family
APASM_RS27035	COG0363	glucosamine-6-phosphate deaminase activity
APASM_RS27040	COG4585	Histidine kinase
APASM_RS27060	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APASM_RS27065	COG0149	triose-phosphate isomerase activity
APASM_RS27070	COG0126	phosphoglycerate kinase activity
APASM_RS27075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APASM_RS27090	COG1481	regulation of sporulation
APASM_RS27100	COG1660	Displays ATPase and GTPase activities
APASM_RS27105	COG0322	excinuclease ABC activity
APASM_RS27160	COG2234	aminopeptidase activity
APASM_RS27170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
APASM_RS27175	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APASM_RS27175	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APASM_RS27205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APASM_RS27210	COG0242	peptide deformylase activity
APASM_RS27240	COG0405	Gamma-glutamyltransferase
APASM_RS27255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APASM_RS27265	COG1758	RNA polymerase activity
APASM_RS27270	COG0194	GDP metabolic process
APASM_RS27280	COG0284	orotidine-5'-phosphate decarboxylase activity
APASM_RS27290	COG0505	Belongs to the CarA family
APASM_RS27305	COG0540	Belongs to the ATCase OTCase family
APASM_RS27310	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APASM_RS27320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APASM_RS27325	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APASM_RS27330	COG0006	proline dipeptidase activity
APASM_RS27340	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APASM_RS27345	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APASM_RS27350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APASM_RS27355	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APASM_RS27365	COG2190	(PTS) system
APASM_RS27370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APASM_RS27375	COG2188	Transcriptional regulator
APASM_RS27380	COG1263	PTS System
APASM_RS27385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APASM_RS27390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APASM_RS27400	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APASM_RS27405	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APASM_RS27445	COG4581	dead DEAH box helicase
APASM_RS27455	COG1388	LysM domain
APASM_RS27465	COG3279	Response regulator of the LytR AlgR family
APASM_RS27475	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APASM_RS27480	COG3275	phosphorelay sensor kinase activity
APASM_RS27510	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APASM_RS27530	COG1733	regulation of RNA biosynthetic process
APASM_RS27550	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
APASM_RS27615	COG0395	ABC-type sugar transport system, permease component
APASM_RS27635	COG1024	Enoyl-CoA hydratase
APASM_RS27660	COG2258	MOSC domain
APASM_RS27665	COG0667	Aldo Keto reductase
APASM_RS27675	COG2030	dehydratase
APASM_RS27675	COG1012	belongs to the aldehyde dehydrogenase family
APASM_RS27690	COG3629	intracellular signal transduction
APASM_RS27690	COG3903	Transcriptional regulator
APASM_RS27695	COG2755	lipolytic protein G-D-S-L family
APASM_RS27695	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
APASM_RS27705	COG1132	(ABC) transporter
APASM_RS27730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APASM_RS27735	COG0564	pseudouridine synthase activity
APASM_RS27785	COG1609	Transcriptional regulator
APASM_RS27830	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APASM_RS27830	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APASM_RS27850	COG1716	ATPase activity
APASM_RS27905	COG0667	Aldo Keto reductase
APASM_RS27950	COG2197	response regulator
APASM_RS27955	COG2197	response regulator
APASM_RS28040	COG1222	aaa ATPase
APASM_RS28085	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
APASM_RS28090	COG1366	Belongs to the anti-sigma-factor antagonist family
APASM_RS28110	COG4977	sequence-specific DNA binding
APASM_RS28160	COG2018	Roadblock/LC7 domain
APASM_RS28170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APASM_RS28180	COG1116	anion transmembrane transporter activity
APASM_RS28180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APASM_RS28185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APASM_RS28190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APASM_RS28200	COG1187	pseudouridine synthase activity
APASM_RS28205	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APASM_RS28210	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
APASM_RS28225	COG0640	Transcriptional regulator
APASM_RS28245	COG0494	nUDIX hydrolase
APASM_RS28250	COG0504	CTP synthase activity
APASM_RS28275	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APASM_RS28285	COG0647	UMP catabolic process
APASM_RS28310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APASM_RS28325	COG2094	Belongs to the DNA glycosylase MPG family
APASM_RS28330	COG0165	Argininosuccinate lyase
APASM_RS28335	COG0137	argininosuccinate synthase activity
APASM_RS28345	COG1438	arginine binding
APASM_RS28360	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APASM_RS28365	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APASM_RS28370	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APASM_RS28375	COG0604	alcohol dehydrogenase
APASM_RS28385	COG1476	TRANSCRIPTIONal
APASM_RS28405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APASM_RS28405	COG0072	phenylalanine-tRNA ligase activity
APASM_RS28410	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APASM_RS28415	COG0326	Molecular chaperone. Has ATPase activity
APASM_RS28425	COG0745	RESPONSE REGULATOR receiver
APASM_RS28435	COG0642	Histidine kinase
APASM_RS28440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APASM_RS28445	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APASM_RS28450	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APASM_RS28455	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APASM_RS28470	COG3629	intracellular signal transduction
APASM_RS28470	COG3903	Transcriptional regulator
APASM_RS28495	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
APASM_RS28500	COG2610	gluconate transmembrane transporter activity
APASM_RS28520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APASM_RS28540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APASM_RS28545	COG0640	Transcriptional regulator
APASM_RS28615	COG5650	phosphatidylinositol metabolic process
APASM_RS28645	COG4946	Tricorn protease homolog
APASM_RS28645	COG0823	Involved in the tonB-independent uptake of proteins
APASM_RS28645	COG1506	peptidase
APASM_RS28655	COG1131	(ABC) transporter
APASM_RS28685	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
APASM_RS28685	COG0237	dephospho-CoA kinase activity
APASM_RS28695	COG0539	negative regulation of cytoplasmic translation
APASM_RS28715	COG1511	domain protein
APASM_RS28720	COG1309	transcriptional regulator
APASM_RS28735	COG0673	inositol 2-dehydrogenase activity
APASM_RS28745	COG2050	protein possibly involved in aromatic compounds catabolism
APASM_RS28755	COG0410	ABC transporter
APASM_RS28800	COG1832	CoA-binding protein
APASM_RS28805	COG0251	oxidation-reduction process
APASM_RS28820	COG1357	PFAM Pentapeptide repeats (8 copies)
APASM_RS28825	COG0514	ATP-dependent DNA helicase (RecQ)
APASM_RS28850	COG1937	Protein conserved in bacteria
APASM_RS28870	COG1595	DNA-templated transcription, initiation
APASM_RS28875	COG1408	metallophosphoesterase
APASM_RS28885	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
APASM_RS28900	COG0778	Nitroreductase
APASM_RS28905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APASM_RS28910	COG0404	The glycine cleavage system catalyzes the degradation of glycine
APASM_RS28920	COG1566	PFAM secretion protein HlyD family protein
APASM_RS28930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APASM_RS28935	COG1960	acyl-CoA dehydrogenase activity
APASM_RS28945	COG0183	Belongs to the thiolase family
APASM_RS28950	COG1250	3-hydroxyacyl-CoA dehydrogenase
APASM_RS28950	COG1024	Enoyl-CoA hydratase
APASM_RS28975	COG1136	(ABC) transporter
APASM_RS28975	COG0577	efflux transmembrane transporter activity
APASM_RS28980	COG0577	efflux transmembrane transporter activity
APASM_RS28980	COG1136	(ABC) transporter
APASM_RS28990	COG3903	Transcriptional regulator
APASM_RS28990	COG3629	intracellular signal transduction
APASM_RS29020	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
APASM_RS29040	COG1946	Acyl-CoA thioesterase
APASM_RS29075	COG0067	glutamate synthase
APASM_RS29075	COG0069	glutamate synthase activity
APASM_RS29075	COG0070	glutamate synthase
APASM_RS29080	COG1301	dicarboxylic acid transport
APASM_RS29090	COG2205	protein histidine kinase activity
APASM_RS29100	COG0745	RESPONSE REGULATOR receiver
APASM_RS29105	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APASM_RS29110	COG0159	tryptophan synthase activity
APASM_RS29115	COG0133	tryptophan synthase activity
APASM_RS29120	COG0134	indole-3-glycerol-phosphate synthase activity
APASM_RS29130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APASM_RS29140	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APASM_RS29150	COG0107	imidazoleglycerol-phosphate synthase activity
APASM_RS29155	COG3654	unkown
APASM_RS29170	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APASM_RS29175	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APASM_RS29185	COG3958	Transketolase
APASM_RS29190	COG3959	Transketolase, thiamine diphosphate binding domain
APASM_RS29200	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
APASM_RS29205	COG0131	Imidazoleglycerol-phosphate dehydratase
APASM_RS29210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APASM_RS29215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APASM_RS29230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APASM_RS29255	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
APASM_RS29285	COG2814	Major facilitator Superfamily
APASM_RS29310	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APASM_RS29325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APASM_RS29340	COG2814	Major facilitator Superfamily
APASM_RS29350	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APASM_RS29360	COG3263	regulation of cellular component size
APASM_RS29380	COG1872	DUF167
APASM_RS29385	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APASM_RS29405	COG1799	cell septum assembly
APASM_RS29420	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APASM_RS29425	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
APASM_RS29430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APASM_RS29435	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APASM_RS29460	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APASM_RS29465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APASM_RS29480	COG0768	penicillin binding
APASM_RS29490	COG0275	rRNA processing
APASM_RS29495	COG2001	Belongs to the MraZ family
APASM_RS29500	COG0714	Associated with various cellular activities
APASM_RS29535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APASM_RS29540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APASM_RS29550	COG0174	glutamine synthetase
APASM_RS29565	COG1192	Involved in chromosome partitioning
APASM_RS29570	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APASM_RS29575	COG0167	dihydroorotate dehydrogenase activity
APASM_RS29585	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS29590	COG2233	PERMEase
APASM_RS29600	COG1842	Phage shock protein A
APASM_RS29605	COG1396	sequence-specific DNA binding
APASM_RS29610	COG1058	Belongs to the CinA family
APASM_RS29610	COG1546	Belongs to the CinA family
APASM_RS29620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APASM_RS29625	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
APASM_RS29650	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
APASM_RS29655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APASM_RS29665	COG0515	serine threonine protein kinase
APASM_RS29675	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
APASM_RS29690	COG1309	transcriptional regulator
APASM_RS29700	COG0667	Aldo Keto reductase
APASM_RS29705	COG3214	Protein conserved in bacteria
APASM_RS29725	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APASM_RS29735	COG1185	polyribonucleotide nucleotidyltransferase activity
APASM_RS29740	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APASM_RS29760	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APASM_RS29775	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
APASM_RS29805	COG0779	Required for maturation of 30S ribosomal subunits
APASM_RS29825	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS29850	COG0442	prolyl-tRNA aminoacylation
APASM_RS29860	COG3022	response to hydroperoxide
APASM_RS29865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APASM_RS29880	COG0513	Belongs to the DEAD box helicase family
APASM_RS29885	COG1648	precorrin-2 dehydrogenase activity
APASM_RS29885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APASM_RS29935	COG0156	8-amino-7-oxononanoate synthase activity
APASM_RS29950	COG1280	lysine exporter protein (LysE YggA)
APASM_RS29965	COG0501	Belongs to the peptidase M48B family
APASM_RS29975	COG0110	maltose O-acetyltransferase activity
APASM_RS29980	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APASM_RS29990	COG1752	Esterase of the alpha-beta hydrolase superfamily
APASM_RS29995	COG0726	polysaccharide deacetylase
APASM_RS30000	COG1881	PFAM PEBP family protein
APASM_RS30010	COG2807	transmembrane transport
APASM_RS30015	COG2186	Transcriptional regulator
APASM_RS30030	COG1492	cobalamin metabolic process
APASM_RS30055	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APASM_RS30060	COG0750	zinc metalloprotease
APASM_RS30065	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
APASM_RS30080	COG2197	response regulator
APASM_RS30085	COG4585	Histidine kinase
APASM_RS30090	COG1177	transmembrane transport
APASM_RS30095	COG1176	ABC-type spermidine putrescine transport system, permease component I
APASM_RS30105	COG3842	ATPase activity
APASM_RS30115	COG0515	serine threonine protein kinase
APASM_RS30125	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APASM_RS30135	COG0667	Aldo Keto reductase
APASM_RS30155	COG0233	cytoplasmic translational termination
APASM_RS30160	COG0528	UMP kinase activity
APASM_RS30165	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APASM_RS30170	COG0052	Belongs to the universal ribosomal protein uS2 family
APASM_RS30180	COG1191	sigma factor activity
APASM_RS30200	COG0792	nuclease activity
APASM_RS30210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APASM_RS30215	COG0681	Belongs to the peptidase S26 family
APASM_RS30220	COG0681	Belongs to the peptidase S26 family
APASM_RS30225	COG0335	large ribosomal subunit rRNA binding
APASM_RS30230	COG0336	Belongs to the RNA methyltransferase TrmD family
APASM_RS30245	COG0228	four-way junction DNA binding
APASM_RS30250	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
APASM_RS30275	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
APASM_RS30295	COG4266	Belongs to the allantoicase family
APASM_RS30300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APASM_RS30325	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
APASM_RS30330	COG1414	Transcriptional regulator
APASM_RS30350	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
APASM_RS30360	COG0454	-acetyltransferase
APASM_RS30360	COG0456	acetyltransferase
APASM_RS30395	COG1254	Belongs to the acylphosphatase family
APASM_RS30400	COG2340	Cysteine-rich secretory protein family
APASM_RS30415	COG1252	NADH dehydrogenase
APASM_RS30430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APASM_RS30440	COG0571	ribonuclease III activity
APASM_RS30445	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APASM_RS30460	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APASM_RS30465	COG0742	ribosomal rna small subunit methyltransferase
APASM_RS30505	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APASM_RS30510	COG1461	Dihydroxyacetone kinase
APASM_RS30515	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APASM_RS30530	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APASM_RS30535	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APASM_RS30560	COG1181	Belongs to the D-alanine--D-alanine ligase family
APASM_RS30610	COG0626	cystathionine gamma-synthase activity
APASM_RS30615	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APASM_RS30625	COG1920	GTP binding
APASM_RS30640	COG0406	alpha-ribazole phosphatase activity
APASM_RS30640	COG0494	nUDIX hydrolase
APASM_RS30650	COG0066	3-isopropylmalate dehydratase activity
APASM_RS30655	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APASM_RS30685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APASM_RS30695	COG0179	Fumarylacetoacetate (FAA) hydrolase
APASM_RS30705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APASM_RS30710	COG0473	3-isopropylmalate dehydrogenase activity
APASM_RS30715	COG1404	Belongs to the peptidase S8 family
APASM_RS30730	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APASM_RS30735	COG0440	acetolactate synthase activity
APASM_RS30755	COG0129	dihydroxy-acid dehydratase activity
APASM_RS30760	COG2259	Doxx family
APASM_RS30805	COG0154	amidase activity
APASM_RS30810	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APASM_RS30825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APASM_RS30840	COG2855	membrane
APASM_RS30860	COG0482	sulfurtransferase activity
APASM_RS30885	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
APASM_RS30895	COG1307	EDD domain protein, DegV family
APASM_RS30910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APASM_RS30935	COG0110	maltose O-acetyltransferase activity
APASM_RS30950	COG2226	methyltransferase
APASM_RS30960	COG1119	ATPase activity
APASM_RS30985	COG0058	SHG alpha-glucan phosphorylase activity
APASM_RS30990	COG0366	Alpha amylase catalytic
APASM_RS30995	COG0366	Alpha amylase catalytic
APASM_RS31005	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APASM_RS31010	COG2321	neutral zinc metallopeptidase
APASM_RS31040	COG1846	Transcriptional regulator
APASM_RS31050	COG2409	Drug exporters of the RND superfamily
APASM_RS31055	COG1131	(ABC) transporter
APASM_RS31070	COG1609	Transcriptional regulator
APASM_RS31085	COG1172	Belongs to the binding-protein-dependent transport system permease family
APASM_RS31090	COG1879	ABC-type sugar transport system periplasmic component
APASM_RS31100	COG0596	Alpha beta hydrolase
APASM_RS31140	COG0183	Belongs to the thiolase family
APASM_RS31145	COG0346	lactoylglutathione lyase activity
APASM_RS31195	COG2376	Dihydroxyacetone kinase
APASM_RS31245	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
APASM_RS31260	COG1024	Enoyl-CoA hydratase
APASM_RS31265	COG1335	isochorismatase
APASM_RS31300	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APASM_RS31305	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APASM_RS31310	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APASM_RS31315	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APASM_RS31320	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APASM_RS31325	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APASM_RS31330	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APASM_RS31335	COG0356	it plays a direct role in the translocation of protons across the membrane
APASM_RS31350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APASM_RS31360	COG2890	protein-(glutamine-N5) methyltransferase activity
APASM_RS31385	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APASM_RS31390	COG0254	rRNA binding
APASM_RS31400	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APASM_RS31405	COG0083	homoserine kinase activity
APASM_RS31410	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APASM_RS31415	COG0460	homoserine dehydrogenase
APASM_RS31420	COG0019	diaminopimelate decarboxylase activity
APASM_RS31425	COG0018	arginyl-trna synthetase
APASM_RS31440	COG3537	Alpha-1,2-mannosidase
APASM_RS31470	COG1056	cytidyltransferase-related domain
APASM_RS31470	COG1051	belongs to the nudix hydrolase family
APASM_RS31500	COG3903	Transcriptional regulator
APASM_RS31500	COG3629	intracellular signal transduction
APASM_RS31505	COG0596	Alpha beta hydrolase
APASM_RS31550	COG1162	GTPase activity
APASM_RS31560	COG0667	Aldo Keto reductase
APASM_RS31565	COG1609	Transcriptional regulator
APASM_RS31605	COG0444	Belongs to the ABC transporter superfamily
APASM_RS31610	COG0601	transmembrane transport
APASM_RS31615	COG4166	transmembrane transport
APASM_RS31630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_RS31640	COG2890	protein-(glutamine-N5) methyltransferase activity
APASM_RS31645	COG4941	Belongs to the sigma-70 factor family
APASM_RS31650	COG3795	YCII-related domain
APASM_RS31680	COG0640	Transcriptional regulator
APASM_RS31690	COG1940	carbohydrate kinase activity
APASM_RS31710	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APASM_RS31715	COG0745	RESPONSE REGULATOR receiver
APASM_RS31720	COG2205	protein histidine kinase activity
APASM_RS31740	COG1404	Belongs to the peptidase S8 family
APASM_RS31755	COG0583	DNA-binding transcription factor activity
APASM_RS31785	COG3629	intracellular signal transduction
APASM_RS31785	COG3903	Transcriptional regulator
APASM_RS31800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APASM_RS31805	COG1960	acyl-CoA dehydrogenase activity
APASM_RS31810	COG1024	Enoyl-CoA hydratase
APASM_RS31820	COG1960	acyl-CoA dehydrogenase activity
APASM_RS31830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
APASM_RS31865	COG3469	chitinase activity
APASM_RS31870	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APASM_RS31880	COG0673	inositol 2-dehydrogenase activity
APASM_RS31900	COG0386	Belongs to the glutathione peroxidase family
APASM_RS31905	COG1760	l-serine dehydratase
APASM_RS31910	COG0509	glycine decarboxylation via glycine cleavage system
APASM_RS31915	COG0686	Belongs to the AlaDH PNT family
APASM_RS31935	COG1132	(ABC) transporter
APASM_RS31940	COG0508	dehydrogenase complex catalyzes the overall conversion of
APASM_RS31940	COG0567	Dehydrogenase, E1 component
APASM_RS31955	COG0667	Aldo Keto reductase
APASM_RS31970	COG3629	intracellular signal transduction
APASM_RS31970	COG3903	Transcriptional regulator
APASM_RS31985	COG1228	amidohydrolase
APASM_RS32000	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
APASM_RS32005	COG2986	histidine ammonia-lyase
APASM_RS32025	COG1174	glycine betaine transport
APASM_RS32065	COG5001	Diguanylate cyclase
APASM_RS32075	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
APASM_RS32100	COG0406	alpha-ribazole phosphatase activity
APASM_RS32120	COG1597	lipid kinase activity
APASM_RS32140	COG5662	AntiSigma factor
APASM_RS32145	COG1595	DNA-templated transcription, initiation
APASM_RS32150	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APASM_RS32160	COG2135	peptidase activity
APASM_RS32165	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APASM_RS32170	COG1162	GTPase activity
APASM_RS32195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APASM_RS32200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APASM_RS32210	COG0653	protein targeting
APASM_RS32215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APASM_RS32220	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APASM_RS32225	COG5401	PFAM Sporulation and spore germination
APASM_RS32230	COG5002	protein histidine kinase activity
APASM_RS32235	COG0745	RESPONSE REGULATOR receiver
APASM_RS32250	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
APASM_RS32255	COG0531	amino acid
APASM_RS32265	COG1482	cell wall glycoprotein biosynthetic process
APASM_RS32305	COG1994	Peptidase M50
APASM_RS32310	COG0391	Required for morphogenesis under gluconeogenic growth conditions
APASM_RS32315	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
APASM_RS32315	COG0778	Nitroreductase
APASM_RS32330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APASM_RS32350	COG0438	transferase activity, transferring glycosyl groups
APASM_RS32370	COG0297	glycogen (starch) synthase activity
APASM_RS32385	COG1316	TRANSCRIPTIONal
APASM_RS32390	COG1316	TRANSCRIPTIONal
APASM_RS32400	COG2259	Doxx family
APASM_RS32430	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
APASM_RS32455	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APASM_RS32460	COG2186	Transcriptional regulator
APASM_RS32500	COG0483	inositol monophosphate 1-phosphatase activity
APASM_RS32505	COG0745	RESPONSE REGULATOR receiver
APASM_RS32510	COG2205	protein histidine kinase activity
APASM_RS32535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APASM_RS32555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
APASM_RS32575	COG0424	maF-like protein
APASM_RS32580	COG1301	dicarboxylic acid transport
APASM_RS32590	COG4770	biotin carboxylase activity
APASM_RS32645	COG2197	response regulator
APASM_RS32650	COG4585	Histidine kinase
APASM_RS32665	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APASM_RS32670	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APASM_RS32675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APASM_RS32690	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
APASM_RS32690	COG1473	amidohydrolase
APASM_RS32720	COG0515	serine threonine protein kinase
APASM_RS32720	COG2815	serine threonine protein kinase
APASM_RS32730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APASM_RS32750	COG3654	unkown
APASM_RS32770	COG5635	Nacht domain
APASM_RS32770	COG2319	Wd-40 repeat
APASM_RS32805	COG3629	intracellular signal transduction
APASM_RS32805	COG3903	Transcriptional regulator
APASM_RS32850	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
APASM_RS32875	COG1079	Belongs to the binding-protein-dependent transport system permease family
APASM_RS32880	COG4603	Belongs to the binding-protein-dependent transport system permease family
APASM_RS32885	COG3845	ABC transporter
APASM_RS32890	COG1744	ABC transporter substrate-binding protein PnrA-like
APASM_RS32955	COG2009	succinate dehydrogenase
APASM_RS32970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APASM_RS32990	COG1295	ribonuclease BN
APASM_RS32995	COG0180	Tryptophanyl-tRNA synthetase
APASM_RS33005	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
APASM_RS33020	COG0708	Exodeoxyribonuclease III
APASM_RS33055	COG0484	heat shock protein binding
APASM_RS33085	COG4555	ABC transporter
APASM_RS33110	COG0039	L-malate dehydrogenase activity
APASM_RS33140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APASM_RS33160	COG0138	bifunctional purine biosynthesis protein purh
APASM_RS33185	COG0045	succinate-CoA ligase (ADP-forming) activity
APASM_RS33245	COG0515	serine threonine protein kinase
APASM_RS33245	COG2815	serine threonine protein kinase
APASM_RS33250	COG0515	serine threonine protein kinase
APASM_RS33255	COG0583	DNA-binding transcription factor activity
APASM_RS33260	COG0697	spore germination
APASM_RS33290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APASM_RS33290	COG0519	Catalyzes the synthesis of GMP from XMP
APASM_RS33300	COG1012	belongs to the aldehyde dehydrogenase family
APASM_RS33315	COG0516	GMP reductase activity
APASM_RS33370	COG0459	protein refolding
APASM_RS33375	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APASM_RS33385	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APASM_RS33390	COG0456	acetyltransferase
APASM_RS33405	COG3118	belongs to the thioredoxin family
APASM_RS33410	COG0318	PFAM AMP-dependent synthetase and ligase
APASM_RS33430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APASM_RS33440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APASM_RS33465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APASM_RS33470	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
APASM_RS33475	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APASM_RS33495	COG0443	Heat shock 70 kDa protein
APASM_RS33505	COG1674	ftsk spoiiie
APASM_RS33515	COG1404	Belongs to the peptidase S8 family
APASM_RS33545	COG1404	Belongs to the peptidase S8 family
APASM_RS33550	COG0101	tRNA pseudouridine synthase activity
APASM_RS33555	COG0203	ribosomal protein L17
APASM_RS33560	COG0202	RNA polymerase activity
APASM_RS33565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APASM_RS33570	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APASM_RS33580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APASM_RS33585	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APASM_RS33605	COG0563	adenylate kinase activity
APASM_RS33625	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APASM_RS33630	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APASM_RS33640	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APASM_RS33645	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APASM_RS33650	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APASM_RS33655	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APASM_RS33660	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APASM_RS33665	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APASM_RS33680	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APASM_RS33685	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APASM_RS33690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APASM_RS33695	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APASM_RS33700	COG0089	rRNA binding
APASM_RS33705	COG0088	Forms part of the polypeptide exit tunnel
APASM_RS33710	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APASM_RS33715	COG0051	transcription antitermination factor activity, RNA binding
APASM_RS33720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APASM_RS33725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APASM_RS33730	COG0049	tRNA binding
APASM_RS33735	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APASM_RS33780	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APASM_RS33785	COG0085	RNA polymerase activity
APASM_RS33810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APASM_RS33840	COG0081	regulation of translation
APASM_RS33845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APASM_RS33855	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APASM_RS33865	COG0436	Aminotransferase
APASM_RS33880	COG2030	dehydratase
APASM_RS33885	COG2030	dehydratase
APASM_RS33890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APASM_RS33935	COG1666	GTP binding
APASM_RS33940	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
APASM_RS33950	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APASM_RS33955	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APASM_RS33960	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APASM_RS33970	COG1834	amidinotransferase
APASM_RS33975	COG1522	sequence-specific DNA binding
APASM_RS33985	COG0674	pyruvate-flavodoxin oxidoreductase activity
APASM_RS33985	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
APASM_RS33990	COG1013	pyruvate-flavodoxin oxidoreductase activity
APASM_RS34010	COG0142	geranyltranstransferase activity
APASM_RS34015	COG1007	ATP synthesis coupled electron transport
APASM_RS34030	COG0713	ATP synthesis coupled electron transport
APASM_RS34040	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APASM_RS34045	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
APASM_RS34050	COG1034	ATP synthesis coupled electron transport
APASM_RS34055	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
APASM_RS34065	COG0649	NAD binding
APASM_RS34070	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APASM_RS34075	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APASM_RS34095	COG2226	methyltransferase
APASM_RS34100	COG0483	inositol monophosphate 1-phosphatase activity
APASM_RS34110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APASM_RS34115	COG2151	metal-sulfur cluster biosynthetic enzyme
APASM_RS34120	COG3396	Phenylacetate-CoA oxygenase
APASM_RS34125	COG3460	Phenylacetate-CoA oxygenase
APASM_RS34130	COG3396	Phenylacetate-CoA oxygenase
APASM_RS34180	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
APASM_RS34230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APASM_RS34240	COG0785	Cytochrome C biogenesis protein
APASM_RS34260	COG0406	alpha-ribazole phosphatase activity
APASM_RS34265	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APASM_RS34305	COG0113	porphobilinogen synthase activity
APASM_RS34315	COG0181	hydroxymethylbilane synthase activity
APASM_RS34320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
APASM_RS34325	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
APASM_RS34345	COG0318	PFAM AMP-dependent synthetase and ligase
APASM_RS34385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APASM_RS34425	COG5002	protein histidine kinase activity
APASM_RS34430	COG0667	Aldo Keto reductase
APASM_RS34440	COG0588	phosphoglycerate mutase activity
APASM_RS34445	COG0318	PFAM AMP-dependent synthetase and ligase
APASM_RS34460	COG0438	transferase activity, transferring glycosyl groups
APASM_RS34480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APASM_RS34510	COG3226	Transcriptional regulator
APASM_RS34525	COG0693	protein deglycase activity
APASM_RS34550	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APASM_RS34555	COG2733	membrane
APASM_RS34585	COG1136	(ABC) transporter
APASM_RS34625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APASM_RS34630	COG2364	Membrane
APASM_RS34690	COG1278	Cold shock
APASM_RS34710	COG2255	four-way junction helicase activity
APASM_RS34775	COG1316	TRANSCRIPTIONal
APASM_RS34795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APASM_RS34815	COG0456	acetyltransferase
APASM_RS34855	COG4044	May play a role in the intracellular transport of hydrophobic ligands
APASM_RS34860	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
APASM_RS34875	COG0735	belongs to the Fur family
APASM_RS34920	COG3718	enzyme involved in inositol metabolism
APASM_RS34930	COG1129	ABC transporter
APASM_RS34935	COG1172	Belongs to the binding-protein-dependent transport system permease family
APASM_RS34945	COG1082	Xylose isomerase domain protein TIM barrel
APASM_RS34960	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APASM_RS34975	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APASM_RS35040	COG1063	alcohol dehydrogenase
APASM_RS35045	COG5001	Diguanylate cyclase
APASM_RS35045	COG3300	MHYT domain
APASM_RS35070	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APASM_RS35075	COG0047	phosphoribosylformylglycinamidine synthase activity
APASM_RS35080	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APASM_RS35105	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
APASM_RS35115	COG0765	amino acid transport
APASM_RS35130	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APASM_RS35140	COG1595	DNA-templated transcription, initiation
APASM_RS35155	COG1595	DNA-templated transcription, initiation
APASM_RS35165	COG1011	Hydrolase
APASM_RS35170	COG0436	Aminotransferase
APASM_RS35215	COG0584	glycerophosphoryl diester phosphodiesterase
APASM_RS35230	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APASM_RS35260	COG4129	membrane
APASM_RS35280	COG0667	Aldo Keto reductase
APASM_RS35285	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS35295	COG1595	DNA-templated transcription, initiation
APASM_RS35320	COG0277	FAD linked oxidase domain protein
APASM_RS35325	COG0586	Pfam SNARE associated Golgi protein
APASM_RS35330	COG1072	(Pantothenic acid kinase))
APASM_RS35335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APASM_RS35365	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APASM_RS35390	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS35400	COG0542	response to heat
APASM_RS35410	COG2871	sodium ion transport
APASM_RS35415	COG0789	Transcriptional regulator
APASM_RS35420	COG0484	heat shock protein binding
APASM_RS35425	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APASM_RS35430	COG0443	Heat shock 70 kDa protein
APASM_RS35450	COG2181	nitrate reductase activity
APASM_RS35450	COG0247	lactate metabolic process
APASM_RS35455	COG1950	PFAM Membrane protein of
APASM_RS35480	COG0717	Belongs to the dCTP deaminase family
APASM_RS35500	COG2197	response regulator
APASM_RS35505	COG1960	acyl-CoA dehydrogenase activity
APASM_RS35520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APASM_RS35550	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS35575	COG1960	acyl-CoA dehydrogenase activity
APASM_RS35585	COG1309	transcriptional regulator
APASM_RS35600	COG0508	dehydrogenase complex catalyzes the overall conversion of
APASM_RS35605	COG0022	dehydrogenase e1 component
APASM_RS35615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APASM_RS35625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APASM_RS35630	COG0765	amino acid transport
APASM_RS35665	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
APASM_RS35695	COG1940	carbohydrate kinase activity
APASM_RS35720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APASM_RS35735	COG4585	Histidine kinase
APASM_RS35740	COG2197	response regulator
APASM_RS35745	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS35755	COG0561	phosphatase activity
APASM_RS35775	COG4585	Histidine kinase
APASM_RS35780	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APASM_RS35800	COG1131	(ABC) transporter
APASM_RS35815	COG0402	S-adenosylhomocysteine deaminase activity
APASM_RS35820	COG4221	oxidoreductase activity
APASM_RS35835	COG2814	Major facilitator Superfamily
APASM_RS35840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APASM_RS35845	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_RS35865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APASM_RS35890	COG0360	Binds together with S18 to 16S ribosomal RNA
APASM_RS35895	COG0629	single-stranded DNA binding
APASM_RS35900	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APASM_RS35905	COG0359	binds to the 23S rRNA
APASM_RS35910	COG0305	Participates in initiation and elongation during chromosome replication
APASM_RS36000	COG0702	epimerase
APASM_RS36005	COG1063	alcohol dehydrogenase
APASM_RS36015	COG0583	DNA-binding transcription factor activity
APASM_RS36035	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APASM_RS36040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APASM_RS36060	COG0495	leucyl-tRNA aminoacylation
APASM_RS36080	COG2197	response regulator
APASM_RS36085	COG0617	tRNA 3'-terminal CCA addition
APASM_RS36105	COG0515	serine threonine protein kinase
APASM_RS36110	COG1595	DNA-templated transcription, initiation
APASM_RS36135	COG0492	ferredoxin-NADP+ reductase activity
APASM_RS36135	COG3118	belongs to the thioredoxin family
APASM_RS36140	COG0860	N-Acetylmuramoyl-L-alanine amidase
APASM_RS36140	COG3409	Peptidoglycan-binding domain 1 protein
APASM_RS36150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APASM_RS36155	COG1181	Belongs to the D-alanine--D-alanine ligase family
APASM_RS36165	COG1192	Involved in chromosome partitioning
APASM_RS36170	COG0357	Ribosomal RNA small subunit methyltransferase G
APASM_RS36185	COG0706	membrane insertase activity
APASM_RS36190	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
APASM_RS36195	COG0594	ribonuclease P activity
APASM_RS36200	COG0230	Belongs to the bacterial ribosomal protein bL34 family