locus-tag	class	description
H2O74_RS00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
H2O74_RS00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
H2O74_RS00015	ENOG4108J5G	6-phosphogluconate dehydrogenase
H2O74_RS00020	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
H2O74_RS00025	ENOG4105K7N	UPF0232 protein
H2O74_RS00030	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
H2O74_RS00035	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
H2O74_RS00105	ENOG4108U4N	(sortase) family
H2O74_RS00125	ENOG4107TPY	serine threonine protein kinase
H2O74_RS00130	ENOG4105CJN	penicillin-binding protein
H2O74_RS00145	ENOG4105HZM	Fha domain containing protein
H2O74_RS00180	ENOG4105W5T	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity)
H2O74_RS00190	ENOG4105E1Q	flagellar hook-associated protein
H2O74_RS00200	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
H2O74_RS00205	ENOG4105I03	Flagellin
H2O74_RS00210	ENOG410804A	Flagellar hook-associated 2 domain-containing protein
H2O74_RS00225	ENOG4105Q75	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
H2O74_RS00230	ENOG4108ZC9	flagellar basal-body rod protein flgc
H2O74_RS00235	ENOG41084Q6	flagellar hook-basal body complex protein fliE
H2O74_RS00240	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
H2O74_RS00245	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
H2O74_RS00275	ENOG4105BZE	flagellar hook protein, FlgE
H2O74_RS00285	ENOG4107R0U	MotA TolQ exbB proton channel
H2O74_RS00290	ENOG4106VK6	Flagellar motor protein
H2O74_RS00305	ENOG4105DD5	Flagellar motor switch protein
H2O74_RS00315	ENOG4105CN7	Flagellar biosynthetic protein FliP
H2O74_RS00320	ENOG4105VS8	Flagellar biosynthetic protein fliq
H2O74_RS00325	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
H2O74_RS00330	ENOG4105D00	flagellar biosynthetic protein flhB
H2O74_RS00335	ENOG4105D7B	Flagellar biosynthesis protein flha
H2O74_RS00345	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
H2O74_RS00365	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
H2O74_RS00370	ENOG4105BZU	Histidine kinase
H2O74_RS00385	ENOG4108VYJ	response regulator receiver protein
H2O74_RS00415	ENOG4105KJF	protein tyrosine phosphatase
H2O74_RS00425	ENOG4105CHM	Aminotransferase
H2O74_RS00430	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H2O74_RS00435	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
H2O74_RS00440	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
H2O74_RS00455	ENOG4105M6F	mutator MutT protein
H2O74_RS00475	ENOG4107FW0	short-chain dehydrogenase reductase
H2O74_RS00490	ENOG4108R3E	Dna-3-methyladenine glycosylase i
H2O74_RS00500	ENOG4105CQ7	ATP-dependent helicase
H2O74_RS00505	ENOG4105EYF	MMPL domain protein
H2O74_RS00510	ENOG4108Z4X	TRANSCRIPTIONal
H2O74_RS00545	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
H2O74_RS00560	ENOG4107ZR7	Membrane
H2O74_RS00570	ENOG4105EYH	Exonuclease
H2O74_RS00585	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
H2O74_RS00595	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
H2O74_RS00610	ENOG4105PDP	Short chain dehydrogenase
H2O74_RS00620	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
H2O74_RS00635	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
H2O74_RS00650	ENOG4107QKA	exodeoxyribonuclease V beta
H2O74_RS00765	ENOG4107R3N	Filamentation induced by cAMP protein fic
H2O74_RS00850	ENOG4105NTW	Transcriptional regulator
H2O74_RS00875	ENOG4105CWX	Alpha-1,2-mannosidase
H2O74_RS00935	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
H2O74_RS00945	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
H2O74_RS00960	ENOG4105DHS	permease protein
H2O74_RS00965	ENOG4105CM4	permease protein
H2O74_RS00970	ENOG4108IPW	abc transporter atp-binding protein
H2O74_RS01000	ENOG4105E2V	Glycosyltransferase 36
H2O74_RS01035	ENOG4105C87	Aminotransferase class I and II
H2O74_RS01045	ENOG4105ETE	Transcriptional regulator (LacI family
H2O74_RS01060	ENOG4105DRS	transport system, permease
H2O74_RS01070	ENOG4108V1T	peptidylprolyl cis-trans isomerase
H2O74_RS01080	ENOG41079Y2	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone
H2O74_RS01090	ENOG4105SYT	Methylenetetrahydrofolate reductase
H2O74_RS01100	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
H2O74_RS01110	ENOG4105BZU	Histidine kinase
H2O74_RS01150	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
H2O74_RS01160	ENOG4105ETE	Transcriptional regulator (LacI family
H2O74_RS01165	ENOG4105EPJ	extracellular solute-binding protein family 1
H2O74_RS01170	ENOG4105S9S	Binding-protein-dependent transport systems, inner membrane component
H2O74_RS01175	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
H2O74_RS01180	ENOG4107AQZ	Membrane
H2O74_RS01185	ENOG4108VC7	Protein of unknown function (DUF2587)
H2O74_RS01190	ENOG4107QKS	N-acylglucosamine 2-epimerase
H2O74_RS01205	ENOG4105GWZ	Roadblock lc7 family protein
H2O74_RS01445	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
H2O74_RS01460	ENOG4105SHT	UspA domain-containing protein
H2O74_RS01465	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
H2O74_RS01490	ENOG4107FW0	short-chain dehydrogenase reductase
H2O74_RS01495	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
H2O74_RS01505	ENOG4108V0P	LemA family
H2O74_RS01540	ENOG4108IUX	(ABC) transporter
H2O74_RS01555	ENOG4107RCW	fructose-bisphosphate aldolase
H2O74_RS01565	ENOG410903D	sensor protein
H2O74_RS01580	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
H2O74_RS01585	ENOG4105C12	Phosphoribosylglycinamide synthetase
H2O74_RS01595	ENOG4105C8V	SAICAR synthetase
H2O74_RS01610	ENOG4105DQ5	transport system permease protein
H2O74_RS01615	ENOG4105TVJ	transport system, permease
H2O74_RS01620	ENOG4105E0A	ABC, transporter
H2O74_RS01625	ENOG4105CD3	dihydroorotase
H2O74_RS01630	ENOG4105CPQ	Dehydrogenase
H2O74_RS01640	ENOG410839H	phosphoribosylformylglycinamidine synthase
H2O74_RS01645	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
H2O74_RS01660	ENOG4105CHR	reductase
H2O74_RS01665	ENOG4105CHU	acetyl-coa acetyltransferase
H2O74_RS01680	ENOG4105D74	hydrolase
H2O74_RS01715	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
H2O74_RS01720	ENOG4106N3A	copper homeostasis protein cutc
H2O74_RS01725	ENOG4105D82	Glutamate dehydrogenase
H2O74_RS01735	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
H2O74_RS01750	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
H2O74_RS01770	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
H2O74_RS01815	ENOG4105Y3U	Transglycosylase-associated protein
H2O74_RS01860	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
H2O74_RS02160	ENOG4107ZHV	Transcriptional regulator
H2O74_RS02165	ENOG41065SU	Two-component system sensor kinase
H2O74_RS02170	ENOG4105BZU	Histidine kinase
H2O74_RS02215	ENOG4105HFS	5'-3' exonuclease
H2O74_RS02230	ENOG4105BZU	Histidine kinase
H2O74_RS02235	ENOG4105BZU	Histidine kinase
H2O74_RS02240	ENOG4105C1J	atp-dependent rna helicase
H2O74_RS02250	ENOG4105RNG	membrane
H2O74_RS02255	ENOG4105K6V	RNA polymerase
H2O74_RS02265	ENOG4105E0X	reductase
H2O74_RS02280	ENOG4105CJ3	phosphate transporter
H2O74_RS02290	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
H2O74_RS02295	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
H2O74_RS02300	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
H2O74_RS02310	ENOG4107V9H	nitrite transporter
H2O74_RS02315	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
H2O74_RS02370	ENOG4108I5C	dEAD DEAH box helicase
H2O74_RS02375	ENOG4105WN5	stage II sporulation protein
H2O74_RS02380	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
H2O74_RS02385	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
H2O74_RS02390	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H2O74_RS02420	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
H2O74_RS02425	ENOG41062IR	nudix hydrolase
H2O74_RS02445	ENOG4108MGF	sugar kinase
H2O74_RS02450	ENOG4105EE0	oxidoreductase
H2O74_RS02455	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
H2O74_RS02460	ENOG4105C6E	dna polymerase iii
H2O74_RS02530	ENOG4105WH1	Two component transcriptional regulator luxr family
H2O74_RS02535	ENOG4105DQE	DNA ligase
H2O74_RS02540	ENOG4105WH1	Two component transcriptional regulator luxr family
H2O74_RS02610	ENOG4105VEQ	Cold shock protein
H2O74_RS02650	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H2O74_RS02655	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
H2O74_RS02675	ENOG4105CQB	FAD linked oxidase domain protein
H2O74_RS02690	ENOG4105CB2	alcohol dehydrogenase
H2O74_RS02705	ENOG4105DWV	Homoserine O-trans-acetylase
H2O74_RS02715	ENOG4105ZXU	NLP P60 protein
H2O74_RS02720	ENOG4105F0N	pyrophosphate phospho-hydrolase
H2O74_RS02725	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
H2O74_RS02735	ENOG4107RD1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
H2O74_RS02745	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
H2O74_RS02750	ENOG4105EUJ	GTP cyclohydrolase i
H2O74_RS02755	ENOG4105EEI	dihydropteroate synthase
H2O74_RS02785	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
H2O74_RS02790	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
H2O74_RS02795	ENOG4108IYU	L-aspartate oxidase
H2O74_RS02815	ENOG4105CRK	lysyL-tRNA synthetase
H2O74_RS02835	ENOG4105C93	Xylose Isomerase
H2O74_RS02845	ENOG4105DFW	ABC transporter
H2O74_RS02855	ENOG4108HWW	ABC transporter
H2O74_RS02865	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
H2O74_RS02870	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
H2O74_RS02880	ENOG4105BZU	Histidine kinase
H2O74_RS02885	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
H2O74_RS02890	ENOG4107QJG	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
H2O74_RS02900	ENOG4105E2Z	phosphate ABC transporter (Permease
H2O74_RS02905	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
H2O74_RS02915	ENOG4108VJ1	Transcriptional regulator (CarD family
H2O74_RS02920	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
H2O74_RS02925	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
H2O74_RS02930	ENOG4108594	Permease of the drug metabolite transporter
H2O74_RS02935	ENOG4105JQN	Transcriptional regulator
H2O74_RS02955	ENOG4105C8N	cysteinyl-tRNA synthetase
H2O74_RS02985	ENOG4107TPY	serine threonine protein kinase
H2O74_RS03055	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
H2O74_RS03075	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
H2O74_RS03095	ENOG4105BZU	Histidine kinase
H2O74_RS03100	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
H2O74_RS03120	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
H2O74_RS03125	ENOG4105CFI	type iii restriction protein res subunit
H2O74_RS03140	ENOG4105VEQ	Cold shock protein
H2O74_RS03165	ENOG4105C7N	Xanthine uracil vitamin C permease
H2O74_RS03170	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
H2O74_RS03180	ENOG4107SFI	Major Facilitator superfamily
H2O74_RS03200	ENOG4107R8H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
H2O74_RS03235	ENOG4105CIK	Amidinotransferase
H2O74_RS03255	ENOG4105CPC	Aldo Keto reductase
H2O74_RS03270	ENOG4105CAY	ferredoxin--nadp reductase
H2O74_RS03305	ENOG4105ETE	Transcriptional regulator (LacI family
H2O74_RS03340	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
H2O74_RS03350	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
H2O74_RS03355	ENOG4107Z96	xylose isomerase
H2O74_RS03360	ENOG4108HHA	Transketolase
H2O74_RS03365	ENOG4108IUS	Transketolase
H2O74_RS03370	ENOG4107RHR	regulatoR
H2O74_RS03465	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
H2O74_RS03505	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
H2O74_RS03510	ENOG4105CYW	agmatinase
H2O74_RS03525	ENOG4105E2T	synthase III
H2O74_RS03530	ENOG410680H	amp-dependent synthetase and ligase
H2O74_RS03535	ENOG4107VBM	3-beta hydroxysteroid dehydrogenase isomerase
H2O74_RS03565	ENOG4105E2D	ec 3.2.1.52
H2O74_RS03585	ENOG4105EG6	Saccharopine dehydrogenase
H2O74_RS03595	ENOG4105DKQ	ROK family
H2O74_RS03600	ENOG4107RNA	Nickel ABC transporter, periplasmic nickel-binding protein
H2O74_RS03610	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
H2O74_RS03615	ENOG4108JQ6	ABC transporter
H2O74_RS03620	ENOG4108JQ7	(ABC) transporter
H2O74_RS03625	ENOG4105E2D	ec 3.2.1.52
H2O74_RS03640	ENOG4105KME	endoribonuclease L-psp
H2O74_RS03645	ENOG4105WH1	Two component transcriptional regulator luxr family
H2O74_RS03655	ENOG4105DAB	fumarate reductase succinate dehydrogenase flavoprotein domain protein
H2O74_RS03660	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
H2O74_RS03670	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
H2O74_RS03680	ENOG4105VMP	Transcriptional regulator
H2O74_RS03695	ENOG4105CEU	Arginine dihydrolase
H2O74_RS03735	ENOG4105BZU	Histidine kinase
H2O74_RS03745	ENOG4107QQG	Dehydrogenase
H2O74_RS03795	ENOG4105UTW	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
H2O74_RS03800	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
H2O74_RS03825	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
H2O74_RS03840	ENOG41079Y2	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone
H2O74_RS03870	ENOG4107TTD	cytosine deaminase
H2O74_RS03880	ENOG4105BZW	Glycerate kinase
H2O74_RS03885	ENOG4105DIA	mandelate racemase muconate lactonizing
H2O74_RS03895	ENOG41079Y2	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone
H2O74_RS03940	ENOG41080FJ	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
H2O74_RS03955	ENOG4105CUJ	penicillin amidase
H2O74_RS03970	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
H2O74_RS03995	ENOG4105E2D	ec 3.2.1.52
H2O74_RS04015	ENOG4105CSW	GntR family transcriptional regulator
H2O74_RS04020	ENOG4108RWI	nicotinamidase
H2O74_RS04030	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
H2O74_RS04035	ENOG4105F8V	Hydrolase, tatD family
H2O74_RS04040	ENOG41069ER	domain protein
H2O74_RS04050	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
H2O74_RS04055	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
H2O74_RS04060	ENOG4105C5H	ABC transporter
H2O74_RS04065	ENOG4108T3F	Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes
H2O74_RS04080	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
H2O74_RS04085	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
H2O74_RS04090	ENOG4107XT7	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
H2O74_RS04095	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
H2O74_RS04100	ENOG4105D3Q	Sugar transferase
H2O74_RS04160	ENOG4107YJ4	chain length determinant protein
H2O74_RS04165	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
H2O74_RS04190	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
H2O74_RS04195	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
H2O74_RS04200	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
H2O74_RS04235	ENOG4105D9F	endo-1,4-beta-xylanase (EC 3.2.1.8)
H2O74_RS04255	ENOG4105I82	acetyl xylan esterase
H2O74_RS04270	ENOG4105QE3	oxidoreductase
H2O74_RS04275	ENOG4105WH1	Two component transcriptional regulator luxr family
H2O74_RS04290	ENOG4105BZU	Histidine kinase
H2O74_RS04305	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
H2O74_RS04320	ENOG4105C7B	Threonine dehydratase
H2O74_RS04325	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
H2O74_RS04335	ENOG4105T1M	mycothiol conjugate amidase mca
H2O74_RS04355	ENOG4105NSK	ABC superfamily ATP binding cassette transporter membrane protein
H2O74_RS04360	ENOG4105BZ1	(ABC) transporter
H2O74_RS04365	ENOG4108W7F	transporter, permease
H2O74_RS04375	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
H2O74_RS04380	ENOG4108IAB	Phoh family
H2O74_RS04385	ENOG4105C9Q	fumarate hydratase class II
H2O74_RS04400	ENOG4105D7K	pfkb domain protein
H2O74_RS04405	ENOG4105YX8	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
H2O74_RS04410	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
H2O74_RS04415	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
H2O74_RS04430	ENOG4105C3G	gtp-binding protein
H2O74_RS04470	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
H2O74_RS04485	ENOG4105CI3	gtp-binding protein typa
H2O74_RS04490	ENOG4108KZ5	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity)
H2O74_RS04510	ENOG4108Z4U	Ferredoxin
H2O74_RS04535	ENOG4107R4C	succinyl-diaminopimelate desuccinylase
H2O74_RS04540	ENOG4108URH	decarboxylase
H2O74_RS04545	ENOG4105EEI	dihydropteroate synthase
H2O74_RS04570	ENOG4105DU6	RNA polymerase
H2O74_RS04580	ENOG4105C0H	protease
H2O74_RS04585	ENOG410630M	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
H2O74_RS04590	ENOG4105C31	Tryptophanyl-tRNA synthetase
H2O74_RS04605	ENOG4105E33	succinate dehydrogenase
H2O74_RS04630	ENOG4107RM1	amidohydrolase
H2O74_RS04635	ENOG4105DIH	basic membrane
H2O74_RS04640	ENOG4108JQ9	ABC transporter
H2O74_RS04645	ENOG4105UIB	(ABC) transporter
H2O74_RS04675	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
H2O74_RS04680	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
H2O74_RS04685	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
H2O74_RS04700	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
H2O74_RS04715	ENOG4108JW7	Maf-like protein
H2O74_RS04720	ENOG4108JIK	carboxylase
H2O74_RS04725	ENOG4107WR6	Maf-like protein
H2O74_RS04735	ENOG4105K5B	UPF0225 protein
H2O74_RS04745	ENOG4105D8K	carboxyl transferase
H2O74_RS04750	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
H2O74_RS04760	ENOG4108RAV	Conserved protein
H2O74_RS04765	ENOG4105C2C	drug resistance transporter, Bcr CflA
H2O74_RS04780	ENOG4105CHR	reductase
H2O74_RS04795	ENOG4107QP8	phosphohexose isomerase
H2O74_RS04805	ENOG4105VEJ	Heat shock protein
H2O74_RS04815	ENOG4105DRR	Transcriptional regulator, GntR family
H2O74_RS04825	ENOG4105CR4	methylisocitrate lyase
H2O74_RS04865	ENOG41062D9	Histidine kinase
H2O74_RS04870	ENOG4105ETX	regulatoR
H2O74_RS04895	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
H2O74_RS04925	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
H2O74_RS04935	ENOG4105C7K	acetolactate synthase
H2O74_RS04965	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
H2O74_RS04970	ENOG4105D7N	magnesium and cobalt transport protein CorA
H2O74_RS04975	ENOG4105CH2	amidohydrolase
H2O74_RS05015	ENOG4105W2C	Glycosyl transferase
H2O74_RS05025	ENOG4105KK4	UPF0060 membrane protein
H2O74_RS05075	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
H2O74_RS05080	ENOG4105ETE	Transcriptional regulator (LacI family
H2O74_RS05090	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
H2O74_RS05105	ENOG4105ZXK	Dehydrogenase
H2O74_RS05110	ENOG4105CMT	Dihydroxyacetone kinase
H2O74_RS05115	ENOG4107YVI	ribose 5-phosphate isomerase
H2O74_RS05130	ENOG4105CUB	amino acid
H2O74_RS05135	ENOG4105DWF	phosphomethylpyrimidine kinase
H2O74_RS05160	ENOG4105C85	amino acid
H2O74_RS05165	ENOG4105C0F	tryptophanase EC 4.1.99.1
H2O74_RS05170	ENOG4108SGR	YheO domain-containing protein
H2O74_RS05175	ENOG4105BZU	Histidine kinase
H2O74_RS05185	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
H2O74_RS05195	ENOG4107RYD	Part of the ABC transporter FtsEX involved in cellular division (By similarity)
H2O74_RS05200	ENOG4105CAK	Cell division ATP-binding protein ftsE
H2O74_RS05225	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
H2O74_RS05235	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
H2O74_RS05255	ENOG4105DRS	transport system, permease
H2O74_RS05330	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
H2O74_RS05340	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
H2O74_RS05345	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
H2O74_RS05350	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
H2O74_RS05355	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
H2O74_RS05370	ENOG4105K63	Thioredoxin
H2O74_RS05390	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
H2O74_RS05425	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
H2O74_RS05440	ENOG410841Q	phosphoesterase PA-phosphatase related protein
H2O74_RS05460	ENOG4105VHU	single-stranded DNA-binding protein
H2O74_RS05475	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
H2O74_RS05485	ENOG4105CGD	Nad-dependent epimerase dehydratase
H2O74_RS05500	ENOG4105C29	acyl-CoA thioesterase
H2O74_RS05510	ENOG410849S	phosphocarrier protein (HPr)
H2O74_RS05530	ENOG4105C5Y	PTS System
H2O74_RS05535	ENOG4107UW8	HAD-superfamily hydrolase subfamily IA variant 3
H2O74_RS05540	ENOG4105D8X	mechanosensitive ion channel
H2O74_RS05565	ENOG4105MC2	DSBA oxidoreductase
H2O74_RS05575	ENOG4105C9K	Endothelin-converting enzyme 1
H2O74_RS05600	ENOG4105K4P	CoA-binding domain protein
H2O74_RS05610	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
H2O74_RS05615	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
H2O74_RS05625	ENOG4105D7T	ABC transporter
H2O74_RS05630	ENOG4105DKK	Benzoate
H2O74_RS05640	ENOG4105FDP	GntR family transcriptional regulator
H2O74_RS05655	ENOG4105D7W	serine acetyltransferase
H2O74_RS05695	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
H2O74_RS05700	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
H2O74_RS05705	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
H2O74_RS05710	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
H2O74_RS05720	ENOG4108IQE	Amp-dependent synthetase and ligase
H2O74_RS05730	ENOG4105EAD	ABC transporter
H2O74_RS05735	ENOG4106PMH	Extracellular solute-binding protein family 3
H2O74_RS05745	ENOG4105C19	ABC transporter
H2O74_RS05755	ENOG41079Y2	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone
H2O74_RS05760	ENOG41088YA	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity)
H2O74_RS05770	ENOG4105E0A	ABC, transporter
H2O74_RS05775	ENOG4105EHG	Permease protein
H2O74_RS05805	ENOG41082VC	UPF0145 protein
H2O74_RS05810	ENOG4108UZX	fmn reductase
H2O74_RS05825	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
H2O74_RS05830	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
H2O74_RS05835	ENOG4105CMT	Dihydroxyacetone kinase
H2O74_RS05840	ENOG4108UTZ	Dihydroxyacetone kinase
H2O74_RS05845	ENOG4105VDH	Dihydroxyacetone kinase
H2O74_RS05885	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
H2O74_RS05900	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
H2O74_RS05915	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
H2O74_RS05930	ENOG41079KZ	Major Facilitator Superfamily
H2O74_RS05935	ENOG4105K5M	30s ribosomal protein S16
H2O74_RS05940	ENOG41082KU	UPF0109 protein
H2O74_RS05945	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
H2O74_RS05950	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
H2O74_RS05955	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
H2O74_RS05965	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
H2O74_RS05975	ENOG41080R2	UPF0102 protein
H2O74_RS05995	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
H2O74_RS06005	ENOG4105CE9	30S ribosomal protein S2
H2O74_RS06010	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
H2O74_RS06015	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
H2O74_RS06020	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
H2O74_RS06025	ENOG4105KNE	Phosphatidate cytidylyltransferase
H2O74_RS06030	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
H2O74_RS06040	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
H2O74_RS06055	ENOG4105WH1	Two component transcriptional regulator luxr family
H2O74_RS06060	ENOG4105C26	Dehydrogenase
H2O74_RS06075	ENOG4105DZP	Membrane-associated zinc metalloprotease
H2O74_RS06080	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
H2O74_RS06100	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
H2O74_RS06110	ENOG4107Z1I	Required for maturation of 30S ribosomal subunits (By similarity)
H2O74_RS06125	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
H2O74_RS06130	ENOG4107ZPY	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
H2O74_RS06135	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
H2O74_RS06145	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
H2O74_RS06150	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
H2O74_RS06155	ENOG4105C1V	Peptidase, M16
H2O74_RS06160	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
H2O74_RS06190	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
H2O74_RS06200	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
H2O74_RS06205	ENOG4105CN5	Metallo-Beta-Lactamase
H2O74_RS06225	ENOG4107QZI	cell division protein FtsK
H2O74_RS06240	ENOG4105CEV	competence damage-inducible protein
H2O74_RS06245	ENOG4105WBV	Transcriptional regulator
H2O74_RS06250	ENOG4108S0J	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity)
H2O74_RS06255	ENOG4107QRT	dEAD DEAH box helicase
H2O74_RS06265	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
H2O74_RS06275	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
H2O74_RS06280	ENOG4105DRP	amino acid AbC transporter
H2O74_RS06285	ENOG4108Q1T	ABC transporter
H2O74_RS06295	ENOG4105CDA	abc transporter atp-binding protein
H2O74_RS06300	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
H2O74_RS06320	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
H2O74_RS06325	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
H2O74_RS06330	ENOG4107Y49	methyltransferase
H2O74_RS06335	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
H2O74_RS06350	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
H2O74_RS06360	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
H2O74_RS06370	ENOG4105CEY	Amp-dependent synthetase and ligase
H2O74_RS06375	ENOG4105CPC	Aldo Keto reductase
H2O74_RS06385	ENOG4108JQ1	Dehydrogenase
H2O74_RS06400	ENOG4105CBS	Chea signal transduction histidine kinase
H2O74_RS06405	ENOG4105BZU	Histidine kinase
H2O74_RS06420	ENOG4108I5G	Major Facilitator superfamily
H2O74_RS06425	ENOG4105VEQ	Cold shock protein
H2O74_RS06440	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
H2O74_RS06460	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
H2O74_RS06465	ENOG4108V6E	Cell division protein mraZ
H2O74_RS06470	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
H2O74_RS06480	ENOG4105CJN	penicillin-binding protein
H2O74_RS06490	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
H2O74_RS06495	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
H2O74_RS06505	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
H2O74_RS06510	ENOG4105DFU	Cell wall formation (By similarity)
H2O74_RS06520	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
H2O74_RS06525	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
H2O74_RS06530	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
H2O74_RS06540	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
H2O74_RS06550	ENOG4107ZIW	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
H2O74_RS06560	ENOG4105C0B	DNA polymerase III (alpha subunit)
H2O74_RS06575	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
H2O74_RS06580	ENOG4105C9U	ATP-dependent DNA helicase RecQ
H2O74_RS06590	ENOG4105CIH	Imidazole acetol-phosphate transaminase
H2O74_RS06595	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
H2O74_RS06605	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
H2O74_RS06610	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
H2O74_RS06625	ENOG4105C0H	protease
H2O74_RS06640	ENOG4105CH6	catalase
H2O74_RS06650	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
H2O74_RS06655	ENOG41084BS	50S ribosomal protein L35
H2O74_RS06660	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
H2O74_RS06665	ENOG4108RWN	rrna methyltransferase
H2O74_RS06675	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
H2O74_RS06680	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
H2O74_RS06685	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
H2O74_RS06690	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
H2O74_RS06695	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
H2O74_RS06700	ENOG4105CAS	nag kinase
H2O74_RS06710	ENOG4105DBV	ornithine carbamoyltransferase
H2O74_RS06715	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
H2O74_RS06720	ENOG4105CDH	Citrulline--aspartate ligase
H2O74_RS06725	ENOG4105CH7	arginosuccinase
H2O74_RS06730	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
H2O74_RS06735	ENOG4108VX5	3-methyladenine DNA glycosylase
H2O74_RS06740	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
H2O74_RS06765	ENOG4105DSU	hydrolase
H2O74_RS06780	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
H2O74_RS06785	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
H2O74_RS06815	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
H2O74_RS06820	ENOG4108YZ4	nudix hydrolase
H2O74_RS06855	ENOG4105JRK	feS assembly protein SufD
H2O74_RS06860	ENOG4105VQD	rieske 2fe-2S domain-containing protein
H2O74_RS06865	ENOG4105C3K	feS assembly ATPase SufC
H2O74_RS06875	ENOG4108UNV	SUF system FeS assembly protein, NifU family
H2O74_RS06880	ENOG4105VG1	fes assembly suf system protein
H2O74_RS06890	ENOG41060NJ	transcriptional regulator
H2O74_RS06925	ENOG4107QCX	Transporter
H2O74_RS06930	ENOG4108JJB	ABC transporter
H2O74_RS06935	ENOG4107ZYJ	bioY protein
H2O74_RS06940	ENOG4105C5H	ABC transporter
H2O74_RS06965	ENOG4105CHR	reductase
H2O74_RS06980	ENOG4105EAC	phosphoserine phosphatase
H2O74_RS06985	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
H2O74_RS06990	ENOG4107QPH	glycogen) synthase
H2O74_RS07000	ENOG4105DKW	ABC transporter
H2O74_RS07050	ENOG4108V1U	phospholipid-binding protein
H2O74_RS07065	ENOG4105C0B	DNA polymerase III (alpha subunit)
H2O74_RS07080	ENOG4107QHE	Choloylglycine hydrolase
H2O74_RS07105	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
H2O74_RS07125	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
H2O74_RS07130	ENOG4105C5H	ABC transporter
H2O74_RS07140	ENOG4105DCF	alanine dehydrogenase
H2O74_RS07150	ENOG4105DGW	oligopeptidase A
H2O74_RS07155	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
H2O74_RS07170	ENOG4105CPC	Aldo Keto reductase
H2O74_RS07175	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
H2O74_RS07180	ENOG4105C8N	cysteinyl-tRNA synthetase
H2O74_RS07215	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
H2O74_RS07220	ENOG4105E5F	proteasome
H2O74_RS07225	ENOG4105WFD	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity)
H2O74_RS07230	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
H2O74_RS07235	ENOG4105F7N	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
H2O74_RS07240	ENOG4105DVV	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity)
H2O74_RS07255	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
H2O74_RS07265	ENOG4105BZ1	(ABC) transporter
H2O74_RS07270	ENOG4105BZ1	(ABC) transporter
H2O74_RS07275	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
H2O74_RS07305	ENOG4105DK0	Indole-3-glycerol phosphate synthase
H2O74_RS07310	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
H2O74_RS07320	ENOG4107TBN	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
H2O74_RS07325	ENOG4105CBC	glutamate synthase
H2O74_RS07360	ENOG4105E7W	lamb ycsf family protein
H2O74_RS07365	ENOG4107R7A	Allophanate hydrolase subunit 2
H2O74_RS07380	ENOG4105NHS	Transcriptional regulator, TraR DksA family
H2O74_RS07400	ENOG4105BZU	Histidine kinase
H2O74_RS07405	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
H2O74_RS07430	ENOG4108IV0	ABC, transporter
H2O74_RS07435	ENOG4105C0Z	ABC transporter
H2O74_RS07440	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
H2O74_RS07445	ENOG4105C32	Amino acid ABC transporter (Permease)
H2O74_RS07470	ENOG4107QN1	sodium solute
H2O74_RS07490	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
H2O74_RS07495	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
H2O74_RS07500	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
H2O74_RS07510	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
H2O74_RS07520	ENOG4105D9P	serine threonine protein kinase
H2O74_RS07530	ENOG4108JMX	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
H2O74_RS07535	ENOG4105BZP	glycoside hydrolase 15-related
H2O74_RS07550	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
H2O74_RS07555	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
H2O74_RS07565	ENOG4105CIE	May be required for sporulation (By similarity)
H2O74_RS07570	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
H2O74_RS07575	ENOG4105BZA	Phosphoglycerate kinase
H2O74_RS07580	ENOG4105CP7	Triose-phosphate isomerase
H2O74_RS07595	ENOG4107XU2	6-phosphogluconolactonase (EC 3.1.1.31)
H2O74_RS07610	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
H2O74_RS07620	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
H2O74_RS07635	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
H2O74_RS07640	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
H2O74_RS07660	ENOG4105CAT	Cytidine monophosphate kinase
H2O74_RS07670	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
H2O74_RS07755	ENOG4106CY5	excisionase
H2O74_RS07815	ENOG41071MT	Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane
H2O74_RS07825	ENOG4105D4B	ABC, transporter
H2O74_RS07830	ENOG4105DKT	Transcriptional regulator
H2O74_RS07835	ENOG4108EMV	Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity)
H2O74_RS07845	ENOG41061GT	Aldolase
H2O74_RS07855	ENOG41067SE	Tetr family transcriptional regulator
H2O74_RS07870	ENOG4105BZU	Histidine kinase
H2O74_RS07920	ENOG4105EEM	helicase
H2O74_RS07925	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
H2O74_RS07930	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
H2O74_RS07940	ENOG4105CUB	amino acid
H2O74_RS07960	ENOG4105D7N	magnesium and cobalt transport protein CorA
H2O74_RS07975	ENOG4108UZE	carboxy-peptidase
H2O74_RS07985	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
H2O74_RS07995	ENOG4105BZ1	(ABC) transporter
H2O74_RS08065	ENOG41079Y2	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone
H2O74_RS08075	ENOG4105DYW	oxidoreductase
H2O74_RS08130	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
H2O74_RS08160	ENOG4107YCR	Transcriptional regulator, ARSR family
H2O74_RS08165	ENOG41089UC	methyltransferase, type 11
H2O74_RS08175	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
H2O74_RS08200	ENOG4105E8G	Major facilitator Superfamily
H2O74_RS08205	ENOG41090KN	UPF0303 protein
H2O74_RS08210	ENOG4105BZ1	(ABC) transporter
H2O74_RS08235	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
H2O74_RS08240	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
H2O74_RS08270	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
H2O74_RS08275	ENOG4105M0N	phosphoribosyl-ATP pyrophosphatase
H2O74_RS08285	ENOG4105DJV	ribulose-phosphate 3-epimerase
H2O74_RS08295	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
H2O74_RS08320	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
H2O74_RS08325	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
H2O74_RS08335	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
H2O74_RS08340	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
H2O74_RS08345	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
H2O74_RS08355	ENOG4105CD3	dihydroorotase
H2O74_RS08360	ENOG4105CXT	aspartate transcarbamylase
H2O74_RS08365	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
H2O74_RS08375	ENOG4105C26	Dehydrogenase
H2O74_RS08380	ENOG4105BZU	Histidine kinase
H2O74_RS08385	ENOG410803B	Involved in the transcription termination process (By similarity)
H2O74_RS08390	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
H2O74_RS08405	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
H2O74_RS08410	ENOG4105D49	3-dehydroquinate synthase
H2O74_RS08415	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
H2O74_RS08420	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
H2O74_RS08470	ENOG4105D7Q	type ii secretion system
H2O74_RS08475	ENOG4105CZX	twitching motility protein
H2O74_RS08480	ENOG4107QHF	type ii secretion system protein e
H2O74_RS08490	ENOG4105HHA	aminodeoxychorismate lyase
H2O74_RS08495	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
H2O74_RS08500	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
H2O74_RS08515	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
H2O74_RS08530	ENOG4107R13	MMPL domain protein
H2O74_RS08545	ENOG4105C9M	aspartyl-trna synthetase
H2O74_RS08550	ENOG410905P	Pyridoxamine 5-phosphate
H2O74_RS08565	ENOG4105CUT	histidyl-tRNA synthetase
H2O74_RS08580	ENOG4105C99	atpase involved in dna repair
H2O74_RS08585	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
H2O74_RS08590	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
H2O74_RS08595	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
H2O74_RS08600	ENOG4107RSV	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
H2O74_RS08610	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
H2O74_RS08615	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
H2O74_RS08620	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
H2O74_RS08625	ENOG4105CDY	transcriptional regulatory protein
H2O74_RS08630	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
H2O74_RS08665	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
H2O74_RS08680	ENOG4105E2K	Glycosyl transferase (Group 1
H2O74_RS08685	ENOG4107YQ3	lipid a biosynthesis lauroyl acyltransferase
H2O74_RS08700	ENOG4105C22	threonyL-tRNA synthetase
H2O74_RS08750	ENOG4105ETE	Transcriptional regulator (LacI family
H2O74_RS08765	ENOG4105CK5	oxidoreductase
H2O74_RS08775	ENOG4105CK5	oxidoreductase
H2O74_RS08785	ENOG4105DKQ	ROK family
H2O74_RS08810	ENOG4105E2D	ec 3.2.1.52
H2O74_RS08840	ENOG4105C8M	UPF0272 protein
H2O74_RS08845	ENOG4105VG5	Membrane
H2O74_RS08870	ENOG4105BZU	Histidine kinase
H2O74_RS08900	ENOG4106PVI	ATP-dependent carboxylate-amine ligase (By similarity)
H2O74_RS08915	ENOG41067RQ	csbd family
H2O74_RS08920	ENOG4105C8M	UPF0272 protein
H2O74_RS08925	ENOG4105DTC	1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase
H2O74_RS08935	ENOG4105CT4	transporter
H2O74_RS08940	ENOG4105CNT	hydrolase family 2
H2O74_RS08945	ENOG4105ETE	Transcriptional regulator (LacI family
H2O74_RS08950	ENOG4105CMG	Carbohydrate kinase
H2O74_RS08955	ENOG4105DEI	Mannitol dehydrogenase
H2O74_RS08965	ENOG4105DSB	aldose 1-epimerase
H2O74_RS09005	ENOG4105P52	geranylgeranyl reductase
H2O74_RS09010	ENOG4107RY6	amino acid
H2O74_RS09065	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
H2O74_RS09075	ENOG4105WH1	Two component transcriptional regulator luxr family
H2O74_RS09085	ENOG4105CHU	acetyl-coa acetyltransferase
H2O74_RS09090	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
H2O74_RS09095	ENOG4105F1A	Pyruvate formate-lyase
H2O74_RS09100	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
H2O74_RS09105	ENOG4105C6N	Formate acetyltransferase
H2O74_RS09115	ENOG4105ERX	Dehydrogenase
H2O74_RS09125	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
H2O74_RS09140	ENOG4107QM5	aconitate hydratase
H2O74_RS09145	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
H2O74_RS09150	ENOG4105C0X	amino acid
H2O74_RS09155	ENOG4107VEG	TrkA-N domain protein
H2O74_RS09180	ENOG4107ZFB	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
H2O74_RS09205	ENOG4107W53	thymidine kinase
H2O74_RS09225	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
H2O74_RS09230	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
H2O74_RS09235	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
H2O74_RS09255	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
H2O74_RS09260	ENOG4105SHT	UspA domain-containing protein
H2O74_RS09290	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
H2O74_RS09310	ENOG4105DKQ	ROK family
H2O74_RS09335	ENOG4108I0Q	anthranilate phosphoribosyltransferase
H2O74_RS09345	ENOG4105CCU	oxidase (Subunit III)
H2O74_RS09355	ENOG4107EUI	c reductase, iron-sulfur
H2O74_RS09360	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
H2O74_RS09370	ENOG4108ZRS	Part of cytochrome c oxidase, its function is
H2O74_RS09375	ENOG4105BZ9	Cytochrome C oxidase, subunit I
H2O74_RS09380	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
H2O74_RS09385	ENOG4107QI6	Cysteine desulfurase
H2O74_RS09390	ENOG4105VFE	sira family
H2O74_RS09405	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
H2O74_RS09420	ENOG4108YZ9	Urea amidohydrolase subunit gamma
H2O74_RS09430	ENOG4108YZ9	Urea amidohydrolase subunit gamma
H2O74_RS09435	ENOG4105CQM	Urea amidohydrolase subunit alpha
H2O74_RS09445	ENOG4107S16	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
H2O74_RS09450	ENOG4105ICD	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
H2O74_RS09470	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
H2O74_RS09475	ENOG41083TI	Protein CrcB homolog
H2O74_RS09480	ENOG4107JBM	CrcB-like protein
H2O74_RS09485	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
H2O74_RS09495	ENOG4105CPC	Aldo Keto reductase
H2O74_RS09510	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
H2O74_RS09525	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
H2O74_RS09555	ENOG4105D9R	oxidoreductase
H2O74_RS09570	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
H2O74_RS09575	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
H2O74_RS09630	ENOG4105BZU	Histidine kinase
H2O74_RS09635	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
H2O74_RS09640	ENOG4105CPQ	Dehydrogenase
H2O74_RS09645	ENOG4105CMG	Carbohydrate kinase
H2O74_RS09655	ENOG4105G6Z	alkaline phosphatase
H2O74_RS09660	ENOG41079Y2	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone
H2O74_RS09680	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
H2O74_RS09690	ENOG4105CV7	Electron transfer flavoprotein
H2O74_RS09695	ENOG4105C1G	acyl-Coa dehydrogenase
H2O74_RS09700	ENOG4108IIG	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity)
H2O74_RS09715	ENOG4105DCG	PHP domain protein
H2O74_RS09720	ENOG4105FDF	Could be involved in DNA repair (By similarity)
H2O74_RS09730	ENOG4105DQE	DNA ligase
H2O74_RS09745	ENOG4105K4P	CoA-binding domain protein
H2O74_RS09750	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
H2O74_RS09755	ENOG4105C5F	glutamine synthetase
H2O74_RS09765	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
H2O74_RS09775	ENOG4105DDN	Pentapeptide repeat-containing protein
H2O74_RS09810	ENOG4105CZM	Major Facilitator
H2O74_RS09820	ENOG4107XFJ	UPF0246 protein
H2O74_RS09860	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
H2O74_RS09880	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
H2O74_RS09885	ENOG41082KT	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
H2O74_RS09890	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
H2O74_RS09900	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
H2O74_RS09940	ENOG4105DRS	transport system, permease
H2O74_RS09955	ENOG4105D4M	Lactamase_B
H2O74_RS09965	ENOG4105ETE	Transcriptional regulator (LacI family
H2O74_RS09975	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
H2O74_RS09995	ENOG4105D9G	High-affinity
H2O74_RS10000	ENOG4105I3K	Ferric uptake regulator, Fur family
H2O74_RS10005	ENOG4105C0A	alcohol dehydrogenase
H2O74_RS10010	ENOG4105CKW	Inner membrane protein yedI
H2O74_RS10020	ENOG4108J20	pectate lyase
H2O74_RS10030	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
H2O74_RS10085	ENOG4107VZS	Nicotinamide-nucleotide adenylyltransferase
H2O74_RS10090	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
H2O74_RS10095	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
H2O74_RS10100	ENOG4107R28	alpha amylase, catalytic region
H2O74_RS10105	ENOG4105EG2	ABC transporter, permease
H2O74_RS10120	ENOG4105ETE	Transcriptional regulator (LacI family
H2O74_RS10125	ENOG4105CG3	alpha amylase, catalytic region
H2O74_RS10140	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
H2O74_RS10145	ENOG4105DSE	periplasmic solute binding protein
H2O74_RS10150	ENOG4105DIK	(ABC) transporter
H2O74_RS10170	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
H2O74_RS10175	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
H2O74_RS10180	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
H2O74_RS10185	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
H2O74_RS10210	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
H2O74_RS10235	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
H2O74_RS10240	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
H2O74_RS10260	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
H2O74_RS10285	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
H2O74_RS10305	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
H2O74_RS10310	ENOG4105BZM	domain protein
H2O74_RS10315	ENOG4105EPR	degv family
H2O74_RS10320	ENOG4105C8T	Leucyl-tRNA synthetase
H2O74_RS10330	ENOG4107R5H	iron (metal) dependent repressor, dtxr family
H2O74_RS10335	ENOG4105CC5	ABC transporter
H2O74_RS10340	ENOG4105DIK	(ABC) transporter
H2O74_RS10350	ENOG4108YYC	ycei family
H2O74_RS10375	ENOG41080R8	Conserved Protein
H2O74_RS10380	ENOG4107QR9	Iron-sulfur cluster binding protein
H2O74_RS10385	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
H2O74_RS10400	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
H2O74_RS10410	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
H2O74_RS10420	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
H2O74_RS10435	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
H2O74_RS10440	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H2O74_RS10445	ENOG4105K46	50S ribosomal protein l27
H2O74_RS10450	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
H2O74_RS10460	ENOG4105C03	ribonuclease
H2O74_RS10465	ENOG4105C4M	(Ubiquinol oxidase) subunit I
H2O74_RS10470	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
H2O74_RS10475	ENOG4108JJ9	ABC, transporter
H2O74_RS10480	ENOG4108JJ8	(ABC) transporter
H2O74_RS10495	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
H2O74_RS10500	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
H2O74_RS10505	ENOG41084BZ	50S ribosomal protein L32
H2O74_RS10520	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
H2O74_RS10525	ENOG4106H78	methyltransferase
H2O74_RS10535	ENOG4105DP4	dak2 domain fusion protein ylov
H2O74_RS10540	ENOG4105VB9	50S ribosomal protein l28
H2O74_RS10560	ENOG4105CPF	Cell wall formation (By similarity)
H2O74_RS10565	ENOG4105CPF	Cell wall formation (By similarity)
H2O74_RS10570	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
H2O74_RS10575	ENOG4108YIQ	Alpha beta hydrolase
H2O74_RS10585	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
H2O74_RS10595	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
H2O74_RS10600	ENOG4105DYW	oxidoreductase
H2O74_RS10605	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
H2O74_RS10610	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
H2O74_RS10615	ENOG41069M3	Transcriptional regulator
H2O74_RS10645	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
H2O74_RS10670	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
H2O74_RS10675	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
H2O74_RS10700	ENOG4108Z66	YbaK ebsC protein
H2O74_RS10705	ENOG410901E	Membrane
H2O74_RS10710	ENOG4105DFA	alanine racemase domain protein
H2O74_RS10715	ENOG4105BZ1	(ABC) transporter
H2O74_RS10725	ENOG4105CHF	Glutathione S-transferase
H2O74_RS10735	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
H2O74_RS10740	ENOG4105CM2	brancheD-chain amino acid aminotransferase
H2O74_RS10745	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
H2O74_RS10750	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
H2O74_RS10755	ENOG4108ZP8	Acetolactate synthase small subunit
H2O74_RS10790	ENOG4107QRS	glycosyltransferase group 2 family protein
H2O74_RS10795	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
H2O74_RS10825	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
H2O74_RS10865	ENOG4105C01	Dihydroxy-acid dehydratase
H2O74_RS10870	ENOG4105KZX	Pterin carbinolamine dehydratase
H2O74_RS10885	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
H2O74_RS10900	ENOG4105ETE	Transcriptional regulator (LacI family
H2O74_RS10905	ENOG4105DUX	Transporter
H2O74_RS10925	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
H2O74_RS10930	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
H2O74_RS10935	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
H2O74_RS10945	ENOG4105WH1	Two component transcriptional regulator luxr family
H2O74_RS10950	ENOG4105DHF	Membrane
H2O74_RS10970	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
H2O74_RS10980	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
H2O74_RS11020	ENOG4105C10	Electron transfer flavoprotein
H2O74_RS11025	ENOG4105BZJ	Electron transfer flavoprotein
H2O74_RS11045	ENOG4105EP6	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
H2O74_RS11055	ENOG41070F3	Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity)
H2O74_RS11060	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
H2O74_RS11090	ENOG4105EBM	Alpha Beta Hydrolase Fold protein
H2O74_RS11100	ENOG4108K4B	hydrolase
H2O74_RS11115	ENOG4105CE4	GlcNAc 6-P deacetylase
H2O74_RS11120	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
H2O74_RS11125	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
H2O74_RS11135	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
H2O74_RS11140	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
H2O74_RS11145	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
H2O74_RS11150	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
H2O74_RS11155	ENOG4108T62	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
H2O74_RS11160	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
H2O74_RS11165	ENOG4105ZA1	atp synthase
H2O74_RS11170	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
H2O74_RS11180	ENOG4105ESV	Glycosyl transferase, family 4
H2O74_RS11190	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
H2O74_RS11195	ENOG4105VFB	Binds the 23S rRNA (By similarity)
H2O74_RS11205	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
H2O74_RS11210	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
H2O74_RS11215	ENOG4105D6E	homoserine dehydrogenase
H2O74_RS11225	ENOG4105C75	arginyL-tRNA synthetase
H2O74_RS11235	ENOG4105JXH	GntR family transcriptional regulator
H2O74_RS11320	ENOG4105C1J	atp-dependent rna helicase
H2O74_RS11325	ENOG4105D85	methylase
H2O74_RS11340	ENOG4105MP0	transposase
H2O74_RS11360	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
H2O74_RS11390	ENOG4105C0A	alcohol dehydrogenase
H2O74_RS11415	ENOG4105C37	(CBS) domain
H2O74_RS11420	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
H2O74_RS11425	ENOG4105EB3	Histidine kinase
H2O74_RS11440	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
H2O74_RS11460	ENOG4105CZX	twitching motility protein
H2O74_RS11470	ENOG4105EMN	RNA polymerase sigma factor
H2O74_RS11480	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
H2O74_RS11485	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
H2O74_RS11490	ENOG4107TK4	histidinol-phosphate phosphatase
H2O74_RS11535	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
H2O74_RS11540	ENOG4105T0Z	Conserved Protein
H2O74_RS11545	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
H2O74_RS11555	ENOG4108T3R	lipoprotein lpqB
H2O74_RS11560	ENOG4105BZU	Histidine kinase
H2O74_RS11565	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
H2O74_RS11580	ENOG4108WQ6	secreted protein
H2O74_RS11615	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
H2O74_RS11620	ENOG4108IJ7	Glycine betaine
H2O74_RS11635	ENOG4105W49	UPF0434 protein
H2O74_RS11640	ENOG4107QKV	phosphomannomutase
H2O74_RS11675	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
H2O74_RS11685	ENOG4105EIP	mannose-6-phosphate isomerase
H2O74_RS11690	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
H2O74_RS11695	ENOG4107QPT	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
H2O74_RS11710	ENOG4105CKK	Glycosyl transferase, family 2
H2O74_RS11725	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
H2O74_RS11735	ENOG4105CKK	Glycosyl transferase, family 2
H2O74_RS11750	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
H2O74_RS11755	ENOG4105C5E	polysaccharide biosynthesis protein
H2O74_RS11760	ENOG4107TY6	Acylneuraminate cytidylyltransferase
H2O74_RS11770	ENOG4105D2T	synthase
H2O74_RS11775	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
H2O74_RS11785	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
H2O74_RS11810	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
H2O74_RS11825	ENOG4105JFG	SpoIID LytB domain protein
H2O74_RS11850	ENOG4105EY8	ABC transporter
H2O74_RS11860	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
H2O74_RS11870	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
H2O74_RS11880	ENOG4108KGH	TRANSCRIPTIONal
H2O74_RS11885	ENOG4108KGH	TRANSCRIPTIONal
H2O74_RS11910	ENOG41065SU	Two-component system sensor kinase
H2O74_RS11915	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
H2O74_RS11920	ENOG4105BZU	Histidine kinase
H2O74_RS11930	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
H2O74_RS11965	ENOG4105ETE	Transcriptional regulator (LacI family
H2O74_RS11980	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
H2O74_RS11985	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
H2O74_RS12005	ENOG4105D82	Glutamate dehydrogenase
H2O74_RS12020	ENOG4105BZU	Histidine kinase
H2O74_RS12025	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
H2O74_RS12030	ENOG4105BZU	Histidine kinase
H2O74_RS12050	ENOG4108IUE	nitrate reductase beta subunit
H2O74_RS12070	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
H2O74_RS12080	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
H2O74_RS12095	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
H2O74_RS12130	ENOG4108UCS	ABC, transporter
H2O74_RS12145	ENOG4107U9T	Pfam:Ribonuclease_BN
H2O74_RS12165	ENOG4105DRS	transport system, permease
H2O74_RS12175	ENOG4105ETE	Transcriptional regulator (LacI family
H2O74_RS12195	ENOG4105BZU	Histidine kinase
H2O74_RS12200	ENOG4105K4I	Scp-like extracellular
H2O74_RS12205	ENOG4105PSV	Polysaccharide Biosynthesis Protein
H2O74_RS12225	ENOG4107EF8	Glycosyl transferase (Group 1
H2O74_RS12230	ENOG4105E2K	Glycosyl transferase (Group 1
H2O74_RS12235	ENOG4105D3Q	Sugar transferase
H2O74_RS12240	ENOG4107YJ4	chain length determinant protein
H2O74_RS12260	ENOG4105BZU	Histidine kinase
H2O74_RS12270	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
H2O74_RS12275	ENOG4105VPX	protein, conserved in bacteria
H2O74_RS12280	ENOG4105CVK	Glutamate decarboxylase
H2O74_RS12285	ENOG4105E5D	amino acid
H2O74_RS12290	ENOG4105C7Z	Conserved Protein
H2O74_RS12305	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
H2O74_RS12310	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
H2O74_RS12400	ENOG41089UC	methyltransferase, type 11
H2O74_RS12425	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
H2O74_RS12430	ENOG4108UXE	Protein tyrosine phosphatase
H2O74_RS12435	ENOG4107RYT	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
H2O74_RS12455	ENOG4107UNS	conserved inner membrane protein
H2O74_RS12465	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
H2O74_RS12475	ENOG4105EYF	MMPL domain protein
H2O74_RS12480	ENOG4105DNP	FAD linked oxidase domain protein
H2O74_RS12495	ENOG4108UJU	UPF0301 protein
H2O74_RS12500	ENOG4105WEF	catalase
H2O74_RS12515	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
H2O74_RS12520	ENOG4105WH1	Two component transcriptional regulator luxr family
H2O74_RS12545	ENOG41060NJ	transcriptional regulator
H2O74_RS12560	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
H2O74_RS12580	ENOG4105DJZ	UPF0182 protein
H2O74_RS12590	ENOG41063PX	domain protein
H2O74_RS12685	ENOG4105C1J	atp-dependent rna helicase
H2O74_RS12700	ENOG41081FY	multiple antibiotic resistance (MarC)-related
H2O74_RS12710	ENOG4107T6F	Xaa-Pro aminopeptidase
H2O74_RS12720	ENOG4105CJW	magnesium transporter
H2O74_RS12735	ENOG4105MVE	transcriptional regulator
H2O74_RS12745	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
H2O74_RS12760	ENOG4105C19	ABC transporter
H2O74_RS12765	ENOG4107RBB	ABC transporter, permease
H2O74_RS12785	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
H2O74_RS12790	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
H2O74_RS12815	ENOG4108HWW	ABC transporter
H2O74_RS12820	ENOG4105C2J	ABC transporter
H2O74_RS12825	ENOG4105DFW	ABC transporter
H2O74_RS12830	ENOG4105E2R	ROK family
H2O74_RS12845	ENOG4105DRR	Transcriptional regulator, GntR family
H2O74_RS12860	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
H2O74_RS12890	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
H2O74_RS12895	ENOG410856B	UPF0235 protein
H2O74_RS12905	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
H2O74_RS12925	ENOG4105DC1	bifunctional purine biosynthesis protein purh
H2O74_RS12950	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
H2O74_RS12965	ENOG4105UYK	outer membrane protein a
H2O74_RS12980	ENOG4105WH1	Two component transcriptional regulator luxr family
H2O74_RS13010	ENOG4105BZU	Histidine kinase
H2O74_RS13015	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
H2O74_RS13035	ENOG4105BZ1	(ABC) transporter
H2O74_RS13040	ENOG4105BZ1	(ABC) transporter
H2O74_RS13065	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
H2O74_RS13075	ENOG4107QRI	Phosphoketolase
H2O74_RS13085	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
H2O74_RS13090	ENOG4105C26	Dehydrogenase
H2O74_RS13095	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
H2O74_RS13100	ENOG4105DE4	1-phosphofructokinase
H2O74_RS13105	ENOG4105JF0	Phosphoenolpyruvate-dependent sugar phosphotransferase system, eiia 2
H2O74_RS13115	ENOG4105CPQ	Dehydrogenase
H2O74_RS13120	ENOG4105E98	transcriptional regulator DeoR family
H2O74_RS13125	ENOG4107QVP	Dehydrogenase
H2O74_RS13130	ENOG4107RKG	DJ-1/PfpI family
H2O74_RS13140	ENOG4105ECY	inositol monophosphatase
H2O74_RS13145	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
H2O74_RS13150	ENOG4105WH1	Two component transcriptional regulator luxr family
H2O74_RS13160	ENOG4105KIU	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
H2O74_RS13165	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
H2O74_RS13175	ENOG4106KXD	ATP-dependent carboxylate-amine ligase (By similarity)
H2O74_RS13190	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
H2O74_RS13195	ENOG41080E2	ribosomal-protein-alanine acetyltransferase
H2O74_RS13205	ENOG4108097	ATP-binding protein
H2O74_RS13210	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
H2O74_RS13215	ENOG4108JJ6	Type I secretion system ATPase
H2O74_RS13225	ENOG4105C3R	Methionine synthase
H2O74_RS13230	ENOG4105EQP	Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity)
H2O74_RS13235	ENOG41082KK	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
H2O74_RS13240	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
H2O74_RS13245	ENOG4105CS9	pantothenic acid kinase
H2O74_RS13255	ENOG4108RBJ	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
H2O74_RS13260	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
H2O74_RS13265	ENOG4108UJD	30S ribosomal protein S9
H2O74_RS13270	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
H2O74_RS13305	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
H2O74_RS13315	ENOG4108ZT0	50S ribosomal protein l17
H2O74_RS13320	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
H2O74_RS13325	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
H2O74_RS13330	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H2O74_RS13340	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
H2O74_RS13350	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
H2O74_RS13355	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
H2O74_RS13360	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
H2O74_RS13365	ENOG410849U	50S ribosomal protein L30
H2O74_RS13370	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
H2O74_RS13380	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
H2O74_RS13385	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
H2O74_RS13390	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
H2O74_RS13395	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H2O74_RS13400	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
H2O74_RS13405	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
H2O74_RS13410	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
H2O74_RS13415	ENOG41082SA	50s ribosomal protein l29
H2O74_RS13420	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
H2O74_RS13425	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
H2O74_RS13430	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
H2O74_RS13435	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
H2O74_RS13440	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H2O74_RS13445	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
H2O74_RS13450	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
H2O74_RS13455	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
H2O74_RS13460	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
H2O74_RS13465	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
H2O74_RS13470	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
H2O74_RS13475	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
H2O74_RS13480	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
H2O74_RS13485	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
H2O74_RS13490	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
H2O74_RS13495	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
H2O74_RS13500	ENOG4108VZM	50s ribosomal protein L10
H2O74_RS13505	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
H2O74_RS13510	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
H2O74_RS13520	ENOG410683Z	Preprotein translocase SecE subunit
H2O74_RS13535	ENOG4105CJ1	ABC, transporter
H2O74_RS13545	ENOG4105BZU	Histidine kinase
H2O74_RS13555	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
H2O74_RS13565	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
H2O74_RS13575	ENOG4107R4N	Cell wall formation (By similarity)
H2O74_RS13580	ENOG4106UW1	Major Facilitator superfamily
H2O74_RS13600	ENOG410900P	UPF0336 protein
H2O74_RS13605	ENOG4105WDJ	50S ribosomal protein L33
H2O74_RS13620	ENOG4108VPT	UPF0234 protein
H2O74_RS13630	ENOG4105D0M	Protease HtpX homolog
H2O74_RS13635	ENOG4105CT1	(ABC) transporter
H2O74_RS13640	ENOG4105EAD	ABC transporter
H2O74_RS13715	ENOG4105EC2	ftsk spoIIIe
H2O74_RS13720	ENOG4105CJ1	ABC, transporter
H2O74_RS13740	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
H2O74_RS13770	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
H2O74_RS13780	ENOG4105D65	subunit l
H2O74_RS13785	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
H2O74_RS13790	ENOG41087XN	oxidoreductase
H2O74_RS13795	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
H2O74_RS13800	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
H2O74_RS13805	ENOG4108IEH	NADH dehydrogenase subunit g
H2O74_RS13820	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
H2O74_RS13830	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
H2O74_RS13845	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
H2O74_RS13850	ENOG4105E4F	Isochorismate synthase
H2O74_RS13865	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
H2O74_RS13870	ENOG4107TCW	O-succinylbenzoate synthase
H2O74_RS13875	ENOG4107SIQ	Naphthoate synthase
H2O74_RS13885	ENOG4108R5T	secreted protein
H2O74_RS13895	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
H2O74_RS13915	ENOG4105CRE	cytochrome C
H2O74_RS13920	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
H2O74_RS13925	ENOG4107QIV	Cytochrome c biogenesis protein
H2O74_RS13935	ENOG4108RH7	phosphoglycerate mutase
H2O74_RS13950	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
H2O74_RS13975	ENOG4105DGU	Histone deacetylase
H2O74_RS13985	ENOG4107ZYR	domain protein
H2O74_RS13990	ENOG41062B0	ABC transporter, permease
H2O74_RS13995	ENOG4107R9N	ABC transporter
H2O74_RS14000	ENOG4107R5U	Periplasmic binding protein LacI transcriptional regulator
H2O74_RS14005	ENOG4108HWW	ABC transporter
H2O74_RS14015	ENOG4105DFW	ABC transporter
H2O74_RS14020	ENOG4105E98	transcriptional regulator DeoR family
H2O74_RS14025	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
H2O74_RS14040	ENOG4105ETE	Transcriptional regulator (LacI family
H2O74_RS14045	ENOG4105II7	pyrroline-5-carboxylate reductase
H2O74_RS14055	ENOG4107QWP	ABC-2 type transporter
H2O74_RS14060	ENOG4105CIG	ABC transporter
H2O74_RS14070	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
H2O74_RS14075	ENOG4105E59	Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity)
H2O74_RS14090	ENOG4105CEN	a g-specific adenine glycosylase
H2O74_RS14140	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
H2O74_RS14145	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
H2O74_RS14150	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
H2O74_RS14155	ENOG4108ZT1	Transcriptional regulator
H2O74_RS14160	ENOG4108KTG	Membrane protein, drug metabolite transporter
H2O74_RS14165	ENOG4105E9Z	Nad-dependent epimerase dehydratase
H2O74_RS14180	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
H2O74_RS14190	ENOG4105ETE	Transcriptional regulator (LacI family
H2O74_RS14195	ENOG4105CXK	mandelate racemase muconate lactonizing
H2O74_RS14200	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
H2O74_RS14205	ENOG4105CHR	reductase
H2O74_RS14210	ENOG4105D7K	pfkb domain protein
H2O74_RS14215	ENOG4108UHU	Aldolase
H2O74_RS14220	ENOG4107258	Transcriptional regulator
H2O74_RS14230	ENOG4105DIA	mandelate racemase muconate lactonizing
H2O74_RS14235	ENOG4105JXH	GntR family transcriptional regulator
H2O74_RS14240	ENOG4105CHR	reductase
H2O74_RS14255	ENOG4105CHR	reductase
H2O74_RS14260	ENOG4107HP6	Transcriptional regulator
H2O74_RS14265	ENOG4105D50	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity)
H2O74_RS14270	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
H2O74_RS14275	ENOG41069H7	transport system small permease component
H2O74_RS14280	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
H2O74_RS14290	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
H2O74_RS14295	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
H2O74_RS14330	ENOG4105EC8	Methyl-accepting chemotaxis
H2O74_RS14345	ENOG4106UW1	Major Facilitator superfamily
H2O74_RS14355	ENOG4108UW5	maltose o-acetyltransferase
H2O74_RS14370	ENOG4105DDC	Oxidoreductase domain protein
H2O74_RS14380	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
H2O74_RS14385	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
H2O74_RS14400	ENOG4105CTX	dehydratase
H2O74_RS14410	ENOG4105D2H	Uronic isomerase
H2O74_RS14415	ENOG41060NJ	transcriptional regulator
H2O74_RS14420	ENOG4105DEI	Mannitol dehydrogenase
H2O74_RS14475	ENOG4105C9U	ATP-dependent DNA helicase RecQ
H2O74_RS14485	ENOG4105DDC	Oxidoreductase domain protein
H2O74_RS14505	ENOG4105CHP	RNA polymerase
H2O74_RS14525	ENOG4105RHA	ABC transporter, permease
H2O74_RS14530	ENOG4108IUX	(ABC) transporter
H2O74_RS14535	ENOG4105WH1	Two component transcriptional regulator luxr family
H2O74_RS14540	ENOG4105BZU	Histidine kinase
H2O74_RS14550	ENOG4105DET	Rhamnulokinase
H2O74_RS14565	ENOG4105M10	Involved in the anomeric conversion of L-rhamnose (By similarity)
H2O74_RS14570	ENOG4105ETE	Transcriptional regulator (LacI family
H2O74_RS14595	ENOG4105CPC	Aldo Keto reductase
H2O74_RS14600	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
H2O74_RS14605	ENOG4105UYK	outer membrane protein a
H2O74_RS14640	ENOG4105I82	acetyl xylan esterase
H2O74_RS14645	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
H2O74_RS14670	ENOG4108AZI	Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity)
H2O74_RS14675	ENOG4105VZ8	Transcriptional regulator
H2O74_RS14690	ENOG4108FN7	Aldo keto reductase
H2O74_RS14695	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
H2O74_RS14715	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
H2O74_RS14720	ENOG4108X6U	May play a role in the intracellular transport of hydrophobic ligands
H2O74_RS14735	ENOG4107NHD	transcriptional regulator
H2O74_RS14740	ENOG4105D74	hydrolase
H2O74_RS14770	ENOG4105BZ4	penicillin-binding protein
H2O74_RS14775	ENOG4105DIN	metallophosphoesterase
H2O74_RS14795	ENOG4105CJ1	ABC, transporter
H2O74_RS14810	ENOG4105CZV	ABC transporter
H2O74_RS14830	ENOG4105CFH	Aspartokinase
H2O74_RS14845	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
H2O74_RS14860	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
H2O74_RS14870	ENOG4105NPE	arsR family transcriptional regulator
H2O74_RS14875	ENOG41090KQ	Glyoxalase Bleomycin resistance protein (Dioxygenase
H2O74_RS14910	ENOG4105BZU	Histidine kinase
H2O74_RS14935	ENOG4105TMB	Formate nitrite transporter
H2O74_RS14945	ENOG4105D22	carbon starvation protein
H2O74_RS14950	ENOG4105CJ1	ABC, transporter
H2O74_RS14975	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
H2O74_RS14980	ENOG4105J76	Periplasmic binding protein
H2O74_RS14985	ENOG4105E0A	ABC, transporter
H2O74_RS14990	ENOG4105C6Z	Gluconate
H2O74_RS14995	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
H2O74_RS15010	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
H2O74_RS15015	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
H2O74_RS15020	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
H2O74_RS15035	ENOG410631K	Membrane
H2O74_RS15050	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
H2O74_RS15055	ENOG4105C2W	permease
H2O74_RS15085	ENOG4105D01	(LipO)protein
H2O74_RS15090	ENOG4108UMI	ABC transporter, permease
H2O74_RS15095	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
H2O74_RS15100	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
H2O74_RS15110	ENOG4105CHH	sulfate transporter
H2O74_RS15120	ENOG4108RDT	NADH dehydrogenase NAD(P)H nitroreductase)
H2O74_RS15135	ENOG4105E2A	Dehydrogenase
H2O74_RS15200	ENOG4108Z6B	deaminase
H2O74_RS15205	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
H2O74_RS15210	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
H2O74_RS15215	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
H2O74_RS15220	ENOG4105D01	(LipO)protein
H2O74_RS15225	ENOG4108UMI	ABC transporter, permease
H2O74_RS15230	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
H2O74_RS15250	ENOG4105EWK	phytoene
H2O74_RS15270	ENOG4105CKK	Glycosyl transferase, family 2
H2O74_RS15295	ENOG4105KNI	merR family transcriptional Regulator
H2O74_RS15300	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
H2O74_RS15305	ENOG4108093	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H2O74_RS15310	ENOG4105CFG	Acts as a chaperone (By similarity)
H2O74_RS15355	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
H2O74_RS15365	ENOG4105CNT	hydrolase family 2
H2O74_RS15385	ENOG4105ETE	Transcriptional regulator (LacI family
H2O74_RS15400	ENOG4105VEQ	Cold shock protein
H2O74_RS15410	ENOG4108KPJ	rna polymerase sigma factor
H2O74_RS15435	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
H2O74_RS15485	ENOG4105BZU	Histidine kinase
H2O74_RS15510	ENOG4105GRZ	Ycii-related protein
H2O74_RS15515	ENOG4105CHP	RNA polymerase
H2O74_RS15520	ENOG4108IG5	Transcriptional regulator
H2O74_RS15550	ENOG4108UCS	ABC, transporter
H2O74_RS15555	ENOG4106SMU	thiamine transporter membrane protein
H2O74_RS15600	ENOG4108JPZ	Monovalent cation H antiporter subunit D
H2O74_RS15605	ENOG4105MKQ	Monovalent cation H antiporter subunit C
H2O74_RS15610	ENOG4105D65	subunit l
H2O74_RS15615	ENOG4105DF6	Fe-S oxidoreductase
H2O74_RS15625	ENOG4105DHP	deoxycytidine triphosphate deaminase
H2O74_RS15655	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
H2O74_RS15660	ENOG4107TDE	lipolytic protein G-D-S-L family
H2O74_RS15665	ENOG4105E4I	Glycoside hydrolase family 28
H2O74_RS15670	ENOG4105ETE	Transcriptional regulator (LacI family
H2O74_RS15680	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
H2O74_RS15735	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
H2O74_RS15755	ENOG4105CEV	competence damage-inducible protein
H2O74_RS15785	ENOG4108FFZ	Transcriptional regulator
H2O74_RS15855	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
H2O74_RS15895	ENOG4106F1P	AAA ATPase, central domain protein
H2O74_RS15905	ENOG4105CT1	(ABC) transporter
H2O74_RS15915	ENOG4107Q25	Serine Threonine protein kinase
H2O74_RS15930	ENOG4105Q36	FHA domain containing protein
H2O74_RS15935	ENOG4105CBX	hi0933 family
H2O74_RS15950	ENOG4107RN0	branched-chain alpha-keto acid dehydrogenase subunit E2
H2O74_RS15955	ENOG4105CPP	Dehydrogenase, E1 component
H2O74_RS15965	ENOG4105IW1	AmiS UreI transporter
H2O74_RS15975	ENOG4105CIH	Imidazole acetol-phosphate transaminase
H2O74_RS15980	ENOG41082T9	Membrane
H2O74_RS16000	ENOG4105NGS	secreted protein
H2O74_RS16015	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
H2O74_RS16050	ENOG4107QTF	adenylosuccinate lyase
H2O74_RS16060	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
H2O74_RS16065	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
H2O74_RS16080	ENOG4107QME	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
H2O74_RS16085	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
H2O74_RS16095	ENOG4105D52	delta-aminolevulinic acid dehydratase
H2O74_RS16100	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
H2O74_RS16115	ENOG4107R28	alpha amylase, catalytic region
H2O74_RS16120	ENOG4105VPX	protein, conserved in bacteria
H2O74_RS16140	ENOG4108M15	ABC transporter
H2O74_RS16170	ENOG4105KPY	Small multidrug resistance protein
H2O74_RS16185	ENOG4105DEN	Luciferase family
H2O74_RS16190	ENOG4105MHT	Transcriptional regulator, ARSR family
H2O74_RS16220	ENOG4105MHT	Transcriptional regulator, ARSR family
H2O74_RS16240	ENOG4105BZU	Histidine kinase
H2O74_RS16245	ENOG4105WH1	Two component transcriptional regulator luxr family
H2O74_RS16265	ENOG4108Z5V	transcriptional regulator, merr family
H2O74_RS16275	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
H2O74_RS16290	ENOG4105CDU	Replicative dna helicase
H2O74_RS16300	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
H2O74_RS16305	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
H2O74_RS16315	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
H2O74_RS16320	ENOG4105BZ4	penicillin-binding protein
H2O74_RS16330	ENOG4105CZA	synthase
H2O74_RS16340	ENOG4105ECR	NmrA family
H2O74_RS16345	ENOG4106TD9	Diguanylate cyclase
H2O74_RS16355	ENOG4105BZU	Histidine kinase
H2O74_RS16365	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
H2O74_RS16385	ENOG4105C3M	thioredoxin reductase
H2O74_RS16390	ENOG4105K63	Thioredoxin
H2O74_RS16395	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
H2O74_RS16405	ENOG4107QJE	Chromosome Partitioning Protein
H2O74_RS16410	ENOG4107XUG	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
H2O74_RS16420	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
H2O74_RS16425	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
H2O74_RS16430	ENOG4105XH8	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
H2O74_RS16435	ENOG41084CH	50S ribosomal protein l34