locus-tag	class	description
H2O74_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H2O74_RS00010	COG0592	DNA-directed DNA polymerase activity
H2O74_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H2O74_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H2O74_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
H2O74_RS00030	COG0187	DNA topoisomerase II activity
H2O74_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H2O74_RS00055	COG2890	protein-(glutamine-N5) methyltransferase activity
H2O74_RS00105	COG3764	Sortase (surface protein transpeptidase)
H2O74_RS00120	COG0515	serine threonine protein kinase
H2O74_RS00125	COG0515	serine threonine protein kinase
H2O74_RS00130	COG0768	penicillin binding
H2O74_RS00145	COG1716	ATPase activity
H2O74_RS00180	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
H2O74_RS00190	COG4786	Flagellar basal body rod
H2O74_RS00190	COG1256	bacterial-type flagellum assembly
H2O74_RS00200	COG1191	sigma factor activity
H2O74_RS00205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H2O74_RS00210	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H2O74_RS00225	COG1815	bacterial-type flagellum-dependent cell motility
H2O74_RS00230	COG1558	bacterial-type flagellum-dependent cell motility
H2O74_RS00235	COG1677	Flagellar hook-basal body complex protein FliE
H2O74_RS00245	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H2O74_RS00255	COG1157	protein secretion by the type III secretion system
H2O74_RS00285	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H2O74_RS00305	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H2O74_RS00305	COG1776	CheC inhibitor of MCP methylation
H2O74_RS00325	COG1684	flagellar biosynthetic protein fliR
H2O74_RS00330	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H2O74_RS00335	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H2O74_RS00345	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H2O74_RS00350	COG0643	Histidine kinase
H2O74_RS00350	COG0784	Response regulator, receiver
H2O74_RS00350	COG2198	Histidine kinase
H2O74_RS00365	COG2201	protein-glutamate methylesterase activity
H2O74_RS00375	COG0745	RESPONSE REGULATOR receiver
H2O74_RS00415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H2O74_RS00425	COG0436	Aminotransferase
H2O74_RS00430	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H2O74_RS00430	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H2O74_RS00435	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H2O74_RS00440	COG0509	glycine decarboxylation via glycine cleavage system
H2O74_RS00445	COG2197	response regulator
H2O74_RS00455	COG0494	nUDIX hydrolase
H2O74_RS00475	COG0300	oxidoreductase activity
H2O74_RS00490	COG2818	Glycosylase
H2O74_RS00500	COG1643	Atp-dependent helicase
H2O74_RS00505	COG2409	Drug exporters of the RND superfamily
H2O74_RS00515	COG3958	Transketolase
H2O74_RS00520	COG3959	Transketolase, thiamine diphosphate binding domain
H2O74_RS00545	COG0823	Involved in the tonB-independent uptake of proteins
H2O74_RS00545	COG1506	peptidase
H2O74_RS00560	COG2855	membrane
H2O74_RS00565	COG0420	3'-5' exonuclease activity
H2O74_RS00570	COG0419	ATPase involved in DNA repair
H2O74_RS00585	COG0813	purine-nucleoside phosphorylase activity
H2O74_RS00610	COG4221	oxidoreductase activity
H2O74_RS00620	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H2O74_RS00635	COG0477	Major facilitator Superfamily
H2O74_RS00650	COG1074	ATP-dependent DNA helicase activity
H2O74_RS00765	COG3177	Filamentation induced by cAMP protein fic
H2O74_RS00805	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
H2O74_RS00805	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
H2O74_RS00850	COG1695	Transcriptional regulator
H2O74_RS00875	COG3537	Alpha-1,2-mannosidase
H2O74_RS00935	COG0009	L-threonylcarbamoyladenylate synthase
H2O74_RS00945	COG2264	protein methyltransferase activity
H2O74_RS00955	COG4607	ABC-type enterochelin transport system periplasmic component
H2O74_RS00960	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2O74_RS00965	COG4605	iron ion homeostasis
H2O74_RS00970	COG4604	ABC transporter, ATP-binding protein
H2O74_RS01000	COG3459	Glycosyltransferase 36 associated
H2O74_RS01035	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H2O74_RS01045	COG1609	Transcriptional regulator
H2O74_RS01055	COG1175	transmembrane transport
H2O74_RS01060	COG0395	ABC-type sugar transport system, permease component
H2O74_RS01070	COG0545	Peptidyl-prolyl cis-trans isomerase
H2O74_RS01080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2O74_RS01090	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H2O74_RS01100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H2O74_RS01150	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H2O74_RS01165	COG1653	transport
H2O74_RS01170	COG1175	transmembrane transport
H2O74_RS01175	COG0395	ABC-type sugar transport system, permease component
H2O74_RS01180	COG5006	permease, DMT superfamily
H2O74_RS01195	COG1028	Short-chain dehydrogenase reductase Sdr
H2O74_RS01195	COG0604	alcohol dehydrogenase
H2O74_RS01195	COG3321	synthase
H2O74_RS01205	COG2018	Roadblock/LC7 domain
H2O74_RS01445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H2O74_RS01460	COG0589	response to stress
H2O74_RS01490	COG0300	oxidoreductase activity
H2O74_RS01495	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H2O74_RS01505	COG1704	LemA family
H2O74_RS01540	COG4152	abc transporter atp-binding protein
H2O74_RS01555	COG0191	fructose-bisphosphate aldolase activity
H2O74_RS01565	COG3920	Histidine kinase
H2O74_RS01580	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H2O74_RS01585	COG0151	Belongs to the GarS family
H2O74_RS01595	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H2O74_RS01610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2O74_RS01615	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2O74_RS01620	COG1120	ATPase activity
H2O74_RS01625	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H2O74_RS01630	COG1063	alcohol dehydrogenase
H2O74_RS01640	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H2O74_RS01645	COG0047	phosphoribosylformylglycinamidine synthase activity
H2O74_RS01655	COG2030	dehydratase
H2O74_RS01660	COG1028	Short-chain dehydrogenase reductase Sdr
H2O74_RS01665	COG0183	Belongs to the thiolase family
H2O74_RS01680	COG0596	Alpha beta hydrolase
H2O74_RS01705	COG1793	dna ligase
H2O74_RS01715	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H2O74_RS01720	COG3142	Participates in the control of copper homeostasis
H2O74_RS01725	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H2O74_RS01735	COG0737	Belongs to the 5'-nucleotidase family
H2O74_RS01750	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H2O74_RS01770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H2O74_RS01770	COG2169	Transcriptional regulator
H2O74_RS01815	COG2261	transglycosylase associated protein
H2O74_RS01860	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H2O74_RS02165	COG2205	protein histidine kinase activity
H2O74_RS02170	COG4251	negative regulation of phosphorylation
H2O74_RS02205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H2O74_RS02215	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H2O74_RS02255	COG1595	DNA-templated transcription, initiation
H2O74_RS02265	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H2O74_RS02280	COG0306	phosphate transporter
H2O74_RS02290	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H2O74_RS02295	COG0456	acetyltransferase
H2O74_RS02300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H2O74_RS02310	COG2116	formate transmembrane transporter activity
H2O74_RS02315	COG1902	pentaerythritol trinitrate reductase activity
H2O74_RS02370	COG1111	helicase
H2O74_RS02370	COG1205	dead DEAH box helicase
H2O74_RS02375	COG1366	Belongs to the anti-sigma-factor antagonist family
H2O74_RS02380	COG1028	Short-chain dehydrogenase reductase Sdr
H2O74_RS02385	COG0546	phosphoglycolate phosphatase activity
H2O74_RS02390	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H2O74_RS02420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H2O74_RS02420	COG1754	DNA topoisomerase type I activity
H2O74_RS02445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2O74_RS02450	COG0673	inositol 2-dehydrogenase activity
H2O74_RS02455	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H2O74_RS02460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H2O74_RS02510	COG1609	Transcriptional regulator
H2O74_RS02530	COG2197	response regulator
H2O74_RS02540	COG2197	response regulator
H2O74_RS02555	COG0673	inositol 2-dehydrogenase activity
H2O74_RS02610	COG1278	Cold shock
H2O74_RS02650	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H2O74_RS02655	COG0574	Belongs to the PEP-utilizing enzyme family
H2O74_RS02655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H2O74_RS02675	COG0247	lactate metabolic process
H2O74_RS02675	COG0277	FAD linked oxidase domain protein
H2O74_RS02690	COG0604	alcohol dehydrogenase
H2O74_RS02705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2O74_RS02715	COG0791	NLP P60 protein
H2O74_RS02715	COG3883	PFAM NLP P60 protein
H2O74_RS02720	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H2O74_RS02725	COG2027	D-alanyl-D-alanine carboxypeptidase
H2O74_RS02735	COG0037	tRNA processing
H2O74_RS02745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H2O74_RS02750	COG0302	gtp cyclohydrolase
H2O74_RS02755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H2O74_RS02760	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H2O74_RS02785	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H2O74_RS02790	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H2O74_RS02795	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H2O74_RS02815	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H2O74_RS02830	COG1070	Carbohydrate kinase
H2O74_RS02835	COG2115	Belongs to the xylose isomerase family
H2O74_RS02845	COG4213	ABC transporter substrate-binding protein
H2O74_RS02855	COG4214	carbohydrate transport
H2O74_RS02865	COG0297	glycogen (starch) synthase activity
H2O74_RS02870	COG0588	phosphoglycerate mutase activity
H2O74_RS02880	COG5002	protein histidine kinase activity
H2O74_RS02885	COG0745	RESPONSE REGULATOR receiver
H2O74_RS02900	COG0581	inorganic phosphate transmembrane transporter activity
H2O74_RS02905	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H2O74_RS02915	COG1329	Transcriptional regulator
H2O74_RS02920	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H2O74_RS02925	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H2O74_RS02930	COG0697	spore germination
H2O74_RS02955	COG0215	cysteine-tRNA ligase activity
H2O74_RS02960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H2O74_RS02970	COG3842	ATPase activity
H2O74_RS02985	COG0515	serine threonine protein kinase
H2O74_RS03055	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H2O74_RS03075	COG0459	protein refolding
H2O74_RS03095	COG2205	protein histidine kinase activity
H2O74_RS03100	COG0745	RESPONSE REGULATOR receiver
H2O74_RS03105	COG1842	Phage shock protein A
H2O74_RS03120	COG0505	Belongs to the CarA family
H2O74_RS03125	COG1061	Type III restriction enzyme res subunit
H2O74_RS03140	COG1278	Cold shock
H2O74_RS03165	COG2252	PERMEase
H2O74_RS03170	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H2O74_RS03180	COG2814	Major facilitator Superfamily
H2O74_RS03200	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H2O74_RS03235	COG1834	amidinotransferase
H2O74_RS03255	COG0667	Aldo Keto reductase
H2O74_RS03270	COG0492	ferredoxin-NADP+ reductase activity
H2O74_RS03290	COG2318	DinB family
H2O74_RS03340	COG1175	transmembrane transport
H2O74_RS03345	COG0395	ABC-type sugar transport system, permease component
H2O74_RS03350	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H2O74_RS03355	COG1082	Xylose isomerase domain protein TIM barrel
H2O74_RS03360	COG3959	Transketolase, thiamine diphosphate binding domain
H2O74_RS03365	COG3958	Transketolase
H2O74_RS03370	COG2390	Transcriptional regulator
H2O74_RS03375	COG1472	Belongs to the glycosyl hydrolase 3 family
H2O74_RS03465	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H2O74_RS03505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H2O74_RS03510	COG0010	Belongs to the arginase family
H2O74_RS03520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H2O74_RS03525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H2O74_RS03530	COG0318	PFAM AMP-dependent synthetase and ligase
H2O74_RS03535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2O74_RS03565	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H2O74_RS03585	COG3268	Saccharopine dehydrogenase
H2O74_RS03595	COG1940	carbohydrate kinase activity
H2O74_RS03600	COG0747	negative chemotaxis
H2O74_RS03605	COG0601	transmembrane transport
H2O74_RS03610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2O74_RS03620	COG4608	Belongs to the ABC transporter superfamily
H2O74_RS03630	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H2O74_RS03645	COG2197	response regulator
H2O74_RS03655	COG1053	succinate dehydrogenase
H2O74_RS03660	COG1902	pentaerythritol trinitrate reductase activity
H2O74_RS03670	COG0363	glucosamine-6-phosphate deaminase activity
H2O74_RS03680	COG3655	Transcriptional regulator
H2O74_RS03695	COG2235	arginine
H2O74_RS03735	COG3706	GGDEF domain
H2O74_RS03795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H2O74_RS03800	COG0805	protein transport
H2O74_RS03825	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H2O74_RS03840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2O74_RS03865	COG0395	ABC-type sugar transport system, permease component
H2O74_RS03870	COG0402	S-adenosylhomocysteine deaminase activity
H2O74_RS03880	COG1929	Belongs to the glycerate kinase type-1 family
H2O74_RS03885	COG4948	Mandelate Racemase Muconate Lactonizing
H2O74_RS03895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2O74_RS03925	COG3239	Fatty acid desaturase
H2O74_RS03940	COG1970	mechanosensitive ion channel activity
H2O74_RS03970	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H2O74_RS04020	COG1335	isochorismatase
H2O74_RS04030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2O74_RS04035	COG0084	hydrolase, TatD family'
H2O74_RS04040	COG3584	3D domain protein
H2O74_RS04040	COG3583	domain protein
H2O74_RS04050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H2O74_RS04055	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H2O74_RS04060	COG0488	(ABC) transporter
H2O74_RS04080	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H2O74_RS04090	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H2O74_RS04095	COG0193	aminoacyl-tRNA hydrolase activity
H2O74_RS04100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H2O74_RS04160	COG0489	protein tyrosine kinase activity
H2O74_RS04165	COG0463	Glycosyl transferase, family 2
H2O74_RS04190	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H2O74_RS04195	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H2O74_RS04200	COG0148	phosphopyruvate hydratase activity
H2O74_RS04225	COG1252	NADH dehydrogenase
H2O74_RS04255	COG3458	cephalosporin-C deacetylase activity
H2O74_RS04270	COG0277	FAD linked oxidase domain protein
H2O74_RS04275	COG2197	response regulator
H2O74_RS04290	COG4585	Histidine kinase
H2O74_RS04305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H2O74_RS04320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H2O74_RS04325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H2O74_RS04335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H2O74_RS04345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H2O74_RS04355	COG4721	ABC-type cobalt transport system, permease component
H2O74_RS04360	COG3845	ABC transporter
H2O74_RS04365	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H2O74_RS04375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H2O74_RS04380	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H2O74_RS04385	COG0114	fumarate hydratase activity
H2O74_RS04405	COG1722	exodeoxyribonuclease VII activity
H2O74_RS04410	COG1570	exodeoxyribonuclease VII activity
H2O74_RS04415	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H2O74_RS04420	COG1322	Protein conserved in bacteria
H2O74_RS04430	COG0012	GTP binding
H2O74_RS04470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2O74_RS04490	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H2O74_RS04535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H2O74_RS04540	COG1611	Belongs to the LOG family
H2O74_RS04545	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H2O74_RS04565	COG4122	O-methyltransferase activity
H2O74_RS04570	COG1595	DNA-templated transcription, initiation
H2O74_RS04580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2O74_RS04585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H2O74_RS04590	COG0180	Tryptophanyl-tRNA synthetase
H2O74_RS04605	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H2O74_RS04620	COG2009	succinate dehydrogenase
H2O74_RS04630	COG1473	amidohydrolase
H2O74_RS04630	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H2O74_RS04675	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H2O74_RS04680	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H2O74_RS04685	COG0584	glycerophosphoryl diester phosphodiesterase
H2O74_RS04700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H2O74_RS04720	COG4770	biotin carboxylase activity
H2O74_RS04725	COG0424	maF-like protein
H2O74_RS04735	COG3012	SEC-C Motif Domain Protein
H2O74_RS04745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H2O74_RS04750	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H2O74_RS04750	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H2O74_RS04760	COG2135	peptidase activity
H2O74_RS04765	COG2814	Major facilitator Superfamily
H2O74_RS04795	COG0166	Belongs to the GPI family
H2O74_RS04815	COG1802	Transcriptional regulator
H2O74_RS04825	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H2O74_RS04855	COG2814	Major facilitator Superfamily
H2O74_RS04860	COG1132	(ABC) transporter
H2O74_RS04870	COG0745	RESPONSE REGULATOR receiver
H2O74_RS04895	COG2890	protein-(glutamine-N5) methyltransferase activity
H2O74_RS04925	COG0477	Major facilitator Superfamily
H2O74_RS04935	COG0028	Belongs to the TPP enzyme family
H2O74_RS04965	COG0039	L-malate dehydrogenase activity
H2O74_RS04970	COG0598	Magnesium transport protein CorA
H2O74_RS04975	COG1473	amidohydrolase
H2O74_RS05015	COG0438	transferase activity, transferring glycosyl groups
H2O74_RS05020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2O74_RS05025	COG1742	UPF0060 membrane protein
H2O74_RS05080	COG1609	Transcriptional regulator
H2O74_RS05090	COG1175	transmembrane transport
H2O74_RS05095	COG0395	ABC-type sugar transport system, permease component
H2O74_RS05105	COG2084	Dehydrogenase
H2O74_RS05110	COG2376	Dihydroxyacetone kinase
H2O74_RS05115	COG0698	ribose 5-phosphate isomerase
H2O74_RS05130	COG0531	amino acid
H2O74_RS05135	COG0351	phosphomethylpyrimidine kinase
H2O74_RS05160	COG1113	amino acid transport
H2O74_RS05175	COG3706	GGDEF domain
H2O74_RS05185	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H2O74_RS05195	COG2177	Part of the ABC transporter FtsEX involved in
H2O74_RS05200	COG2884	Cell division ATP-binding protein ftsE
H2O74_RS05225	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H2O74_RS05235	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H2O74_RS05250	COG1175	transmembrane transport
H2O74_RS05255	COG0395	ABC-type sugar transport system, permease component
H2O74_RS05330	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H2O74_RS05340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H2O74_RS05350	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H2O74_RS05355	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H2O74_RS05360	COG0488	(ABC) transporter
H2O74_RS05390	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H2O74_RS05440	COG0671	phosphoesterase, PA-phosphatase related
H2O74_RS05455	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H2O74_RS05460	COG0629	single-stranded DNA binding
H2O74_RS05475	COG1160	GTP binding
H2O74_RS05485	COG0702	epimerase
H2O74_RS05490	COG0477	Major facilitator Superfamily
H2O74_RS05500	COG1946	Acyl-CoA thioesterase
H2O74_RS05510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2O74_RS05515	COG1263	PTS System
H2O74_RS05520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2O74_RS05525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2O74_RS05530	COG2190	(PTS) system
H2O74_RS05535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H2O74_RS05540	COG0668	transmembrane transport
H2O74_RS05545	COG1505	serine-type exopeptidase activity
H2O74_RS05565	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H2O74_RS05575	COG3590	peptidase
H2O74_RS05585	COG4552	Acetyltransferase involved in intracellular survival and related
H2O74_RS05600	COG1832	CoA-binding protein
H2O74_RS05610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H2O74_RS05615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2O74_RS05625	COG1116	anion transmembrane transporter activity
H2O74_RS05630	COG3135	benzoate transporter
H2O74_RS05640	COG2188	Transcriptional regulator
H2O74_RS05655	COG1045	serine acetyltransferase
H2O74_RS05695	COG0544	peptidyl-prolyl cis-trans isomerase activity
H2O74_RS05705	COG0740	serine-type endopeptidase activity
H2O74_RS05710	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H2O74_RS05720	COG1022	Amp-dependent synthetase and ligase
H2O74_RS05730	COG0765	amino acid transport
H2O74_RS05745	COG1136	(ABC) transporter
H2O74_RS05755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2O74_RS05760	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
H2O74_RS05760	COG0778	Nitroreductase
H2O74_RS05770	COG1120	ATPase activity
H2O74_RS05775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2O74_RS05810	COG0431	NADPH-dependent FMN reductase
H2O74_RS05825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H2O74_RS05830	COG0285	dihydrofolate synthase activity
H2O74_RS05835	COG2376	Dihydroxyacetone kinase
H2O74_RS05840	COG1461	Dihydroxyacetone kinase
H2O74_RS05845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H2O74_RS05845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2O74_RS05845	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
H2O74_RS05885	COG0105	UTP biosynthetic process
H2O74_RS05915	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H2O74_RS05930	COG0477	Major facilitator Superfamily
H2O74_RS05935	COG0228	four-way junction DNA binding
H2O74_RS05940	COG1837	Belongs to the UPF0109 family
H2O74_RS05945	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H2O74_RS05950	COG0336	Belongs to the RNA methyltransferase TrmD family
H2O74_RS05955	COG0335	large ribosomal subunit rRNA binding
H2O74_RS05960	COG0681	Belongs to the peptidase S26 family
H2O74_RS05965	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H2O74_RS05975	COG0792	nuclease activity
H2O74_RS05995	COG1191	sigma factor activity
H2O74_RS06005	COG0052	Belongs to the universal ribosomal protein uS2 family
H2O74_RS06010	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H2O74_RS06020	COG0233	cytoplasmic translational termination
H2O74_RS06025	COG0575	Belongs to the CDS family
H2O74_RS06030	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H2O74_RS06040	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H2O74_RS06055	COG2197	response regulator
H2O74_RS06060	COG1012	belongs to the aldehyde dehydrogenase family
H2O74_RS06075	COG0750	zinc metalloprotease
H2O74_RS06080	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H2O74_RS06095	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H2O74_RS06100	COG0442	prolyl-tRNA aminoacylation
H2O74_RS06110	COG0779	Required for maturation of 30S ribosomal subunits
H2O74_RS06125	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H2O74_RS06130	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H2O74_RS06135	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H2O74_RS06145	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H2O74_RS06150	COG1185	polyribonucleotide nucleotidyltransferase activity
H2O74_RS06155	COG0612	Peptidase, M16
H2O74_RS06160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H2O74_RS06190	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H2O74_RS06200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2O74_RS06205	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H2O74_RS06225	COG1674	ftsk spoiiie
H2O74_RS06240	COG1058	Belongs to the CinA family
H2O74_RS06240	COG1546	Belongs to the CinA family
H2O74_RS06245	COG1396	sequence-specific DNA binding
H2O74_RS06250	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H2O74_RS06255	COG1201	RNA secondary structure unwinding
H2O74_RS06265	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H2O74_RS06275	COG1418	mRNA catabolic process
H2O74_RS06280	COG0765	amino acid transport
H2O74_RS06285	COG0765	amino acid transport
H2O74_RS06295	COG1126	abc transporter atp-binding protein
H2O74_RS06300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H2O74_RS06320	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H2O74_RS06325	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H2O74_RS06330	COG2813	Specifically methylates the guanine in position
H2O74_RS06335	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H2O74_RS06350	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H2O74_RS06360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H2O74_RS06370	COG0318	PFAM AMP-dependent synthetase and ligase
H2O74_RS06375	COG0667	Aldo Keto reductase
H2O74_RS06385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H2O74_RS06405	COG4251	negative regulation of phosphorylation
H2O74_RS06410	COG0784	Response regulator, receiver
H2O74_RS06420	COG2271	Major facilitator Superfamily
H2O74_RS06425	COG1278	Cold shock
H2O74_RS06440	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2O74_RS06460	COG0714	Associated with various cellular activities
H2O74_RS06465	COG2001	Belongs to the MraZ family
H2O74_RS06470	COG0275	rRNA processing
H2O74_RS06480	COG0768	penicillin binding
H2O74_RS06490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H2O74_RS06495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H2O74_RS06505	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H2O74_RS06510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H2O74_RS06520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H2O74_RS06530	COG1799	cell septum assembly
H2O74_RS06540	COG3599	regulation of cell shape
H2O74_RS06550	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H2O74_RS06560	COG0587	DNA-directed DNA polymerase activity
H2O74_RS06575	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H2O74_RS06590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H2O74_RS06595	COG0131	Imidazoleglycerol-phosphate dehydratase
H2O74_RS06605	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H2O74_RS06610	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H2O74_RS06625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2O74_RS06650	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H2O74_RS06655	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H2O74_RS06660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H2O74_RS06665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H2O74_RS06675	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H2O74_RS06690	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H2O74_RS06695	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H2O74_RS06700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H2O74_RS06710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H2O74_RS06715	COG1438	arginine binding
H2O74_RS06720	COG0137	argininosuccinate synthase activity
H2O74_RS06725	COG0165	Argininosuccinate lyase
H2O74_RS06730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H2O74_RS06735	COG2094	Belongs to the DNA glycosylase MPG family
H2O74_RS06740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H2O74_RS06765	COG0647	UMP catabolic process
H2O74_RS06780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H2O74_RS06785	COG0497	DNA recombination
H2O74_RS06815	COG0504	CTP synthase activity
H2O74_RS06820	COG0494	nUDIX hydrolase
H2O74_RS06855	COG0719	Fe-S assembly protein
H2O74_RS06860	COG2146	nitrite reductase [NAD(P)H] activity
H2O74_RS06865	COG0396	ATPase activity
H2O74_RS06875	COG0822	iron-sulfur transferase activity
H2O74_RS06880	COG2151	metal-sulfur cluster biosynthetic enzyme
H2O74_RS06890	COG1609	Transcriptional regulator
H2O74_RS06895	COG1653	transport
H2O74_RS06925	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H2O74_RS06930	COG1122	ATPase activity
H2O74_RS06935	COG1268	BioY protein
H2O74_RS06940	COG0488	(ABC) transporter
H2O74_RS06965	COG1028	Short-chain dehydrogenase reductase Sdr
H2O74_RS06980	COG0560	Phosphoserine phosphatase
H2O74_RS06980	COG3830	Belongs to the UPF0237 family
H2O74_RS06990	COG0297	glycogen (starch) synthase activity
H2O74_RS07000	COG1119	ATPase activity
H2O74_RS07050	COG1881	PFAM PEBP family protein
H2O74_RS07065	COG0587	DNA-directed DNA polymerase activity
H2O74_RS07080	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
H2O74_RS07105	COG1136	(ABC) transporter
H2O74_RS07125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H2O74_RS07130	COG0488	(ABC) transporter
H2O74_RS07140	COG0686	Belongs to the AlaDH PNT family
H2O74_RS07150	COG0339	signal peptide processing
H2O74_RS07155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H2O74_RS07170	COG0667	Aldo Keto reductase
H2O74_RS07175	COG1968	undecaprenyl-diphosphatase activity
H2O74_RS07180	COG0215	cysteine-tRNA ligase activity
H2O74_RS07215	COG1222	aaa ATPase
H2O74_RS07230	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H2O74_RS07235	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H2O74_RS07240	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H2O74_RS07255	COG0107	imidazoleglycerol-phosphate synthase activity
H2O74_RS07265	COG1132	(ABC) transporter
H2O74_RS07270	COG1132	(ABC) transporter
H2O74_RS07275	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H2O74_RS07305	COG0134	indole-3-glycerol-phosphate synthase activity
H2O74_RS07310	COG0133	tryptophan synthase activity
H2O74_RS07315	COG0159	tryptophan synthase activity
H2O74_RS07320	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H2O74_RS07325	COG0067	glutamate synthase
H2O74_RS07325	COG0069	glutamate synthase activity
H2O74_RS07325	COG0070	glutamate synthase
H2O74_RS07360	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H2O74_RS07365	COG1984	allophanate hydrolase subunit 2
H2O74_RS07380	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H2O74_RS07400	COG3706	GGDEF domain
H2O74_RS07405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H2O74_RS07470	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2O74_RS07490	COG0539	negative regulation of cytoplasmic translation
H2O74_RS07495	COG0237	dephospho-CoA kinase activity
H2O74_RS07500	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H2O74_RS07510	COG0556	nucleotide-excision repair
H2O74_RS07520	COG2815	serine threonine protein kinase
H2O74_RS07520	COG0515	serine threonine protein kinase
H2O74_RS07530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2O74_RS07535	COG3387	PFAM Glycoside hydrolase 15-related
H2O74_RS07550	COG0322	excinuclease ABC activity
H2O74_RS07555	COG1660	Displays ATPase and GTPase activities
H2O74_RS07565	COG1481	regulation of sporulation
H2O74_RS07570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H2O74_RS07575	COG0126	phosphoglycerate kinase activity
H2O74_RS07580	COG0149	triose-phosphate isomerase activity
H2O74_RS07585	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H2O74_RS07595	COG0363	glucosamine-6-phosphate deaminase activity
H2O74_RS07610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H2O74_RS07620	COG0109	protoheme IX farnesyltransferase activity
H2O74_RS07635	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H2O74_RS07640	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H2O74_RS07660	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H2O74_RS07670	COG1160	GTP binding
H2O74_RS07815	COG1172	Belongs to the binding-protein-dependent transport system permease family
H2O74_RS07825	COG1879	ABC-type sugar transport system periplasmic component
H2O74_RS07835	COG1070	Carbohydrate kinase
H2O74_RS07845	COG1830	Aldolase
H2O74_RS07855	COG1309	transcriptional regulator
H2O74_RS07870	COG3300	MHYT domain
H2O74_RS07870	COG5001	Diguanylate cyclase
H2O74_RS07880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2O74_RS07920	COG3973	AAA domain
H2O74_RS07925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2O74_RS07930	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H2O74_RS07930	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H2O74_RS07940	COG0531	amino acid
H2O74_RS07945	COG1472	Belongs to the glycosyl hydrolase 3 family
H2O74_RS07960	COG0598	Magnesium transport protein CorA
H2O74_RS07975	COG1876	peptidase activity
H2O74_RS07995	COG3845	ABC transporter
H2O74_RS08065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2O74_RS08075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2O74_RS08130	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H2O74_RS08160	COG0640	Transcriptional regulator
H2O74_RS08165	COG2226	methyltransferase
H2O74_RS08175	COG1028	Short-chain dehydrogenase reductase Sdr
H2O74_RS08205	COG4702	Belongs to the UPF0303 family
H2O74_RS08210	COG1132	(ABC) transporter
H2O74_RS08235	COG0805	protein transport
H2O74_RS08240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H2O74_RS08270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H2O74_RS08275	COG0140	phosphoribosyl-ATP diphosphatase activity
H2O74_RS08285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H2O74_RS08295	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H2O74_RS08310	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H2O74_RS08320	COG1758	RNA polymerase activity
H2O74_RS08325	COG0194	GDP metabolic process
H2O74_RS08335	COG0284	orotidine-5'-phosphate decarboxylase activity
H2O74_RS08340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H2O74_RS08345	COG0505	Belongs to the CarA family
H2O74_RS08355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H2O74_RS08360	COG0540	Belongs to the ATCase OTCase family
H2O74_RS08365	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H2O74_RS08375	COG1012	belongs to the aldehyde dehydrogenase family
H2O74_RS08380	COG5001	Diguanylate cyclase
H2O74_RS08380	COG3300	MHYT domain
H2O74_RS08385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H2O74_RS08390	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H2O74_RS08405	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H2O74_RS08410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H2O74_RS08415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H2O74_RS08420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H2O74_RS08440	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H2O74_RS08470	COG1459	type II secretion system
H2O74_RS08480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H2O74_RS08485	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H2O74_RS08490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H2O74_RS08495	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H2O74_RS08500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H2O74_RS08515	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H2O74_RS08530	COG2409	Drug exporters of the RND superfamily
H2O74_RS08545	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H2O74_RS08550	COG3467	pyridoxamine 5'-phosphate
H2O74_RS08565	COG0124	histidyl-tRNA synthetase
H2O74_RS08580	COG1196	nuclear chromosome segregation
H2O74_RS08585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H2O74_RS08590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H2O74_RS08595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H2O74_RS08600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H2O74_RS08610	COG2255	four-way junction helicase activity
H2O74_RS08615	COG0632	four-way junction helicase activity
H2O74_RS08620	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H2O74_RS08625	COG0217	transcriptional regulatory protein
H2O74_RS08630	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
H2O74_RS08660	COG0494	nUDIX hydrolase
H2O74_RS08665	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
H2O74_RS08680	COG0438	transferase activity, transferring glycosyl groups
H2O74_RS08685	COG1560	Kdo2-lipid A biosynthetic process
H2O74_RS08690	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H2O74_RS08700	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H2O74_RS08715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H2O74_RS08720	COG0512	Glutamine amidotransferase of anthranilate synthase
H2O74_RS08720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H2O74_RS08765	COG0673	inositol 2-dehydrogenase activity
H2O74_RS08775	COG0673	inositol 2-dehydrogenase activity
H2O74_RS08785	COG1940	carbohydrate kinase activity
H2O74_RS08790	COG1175	transmembrane transport
H2O74_RS08805	COG3408	Glycogen debranching enzyme
H2O74_RS08840	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
H2O74_RS08845	COG2149	membrane
H2O74_RS08900	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H2O74_RS08915	COG3237	CsbD-like
H2O74_RS08920	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
H2O74_RS08925	COG1691	(AIR) carboxylase
H2O74_RS08930	COG1606	tRNA processing
H2O74_RS08940	COG3250	beta-galactosidase activity
H2O74_RS08945	COG1609	Transcriptional regulator
H2O74_RS08950	COG1070	Carbohydrate kinase
H2O74_RS08955	COG0246	Mannitol dehydrogenase
H2O74_RS08965	COG0676	glucose-6-phosphate 1-epimerase activity
H2O74_RS09000	COG1755	Isoprenylcysteine carboxyl methyltransferase
H2O74_RS09005	COG0644	oxidoreductase
H2O74_RS09010	COG0531	amino acid
H2O74_RS09065	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H2O74_RS09075	COG2197	response regulator
H2O74_RS09085	COG0183	Belongs to the thiolase family
H2O74_RS09090	COG1024	Enoyl-CoA hydratase
H2O74_RS09090	COG1250	3-hydroxyacyl-CoA dehydrogenase
H2O74_RS09095	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H2O74_RS09100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2O74_RS09105	COG1882	Formate acetyltransferase
H2O74_RS09115	COG0516	GMP reductase activity
H2O74_RS09115	COG0517	IMP dehydrogenase activity
H2O74_RS09125	COG0519	Catalyzes the synthesis of GMP from XMP
H2O74_RS09125	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H2O74_RS09140	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H2O74_RS09145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H2O74_RS09150	COG0531	amino acid
H2O74_RS09155	COG0569	domain protein
H2O74_RS09180	COG0756	dUTP diphosphatase activity
H2O74_RS09205	COG1435	thymidine kinase activity
H2O74_RS09225	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H2O74_RS09230	COG0456	acetyltransferase
H2O74_RS09230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H2O74_RS09235	COG0187	DNA topoisomerase II activity
H2O74_RS09255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H2O74_RS09260	COG0589	response to stress
H2O74_RS09285	COG0515	serine threonine protein kinase
H2O74_RS09285	COG2815	serine threonine protein kinase
H2O74_RS09290	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H2O74_RS09310	COG1940	carbohydrate kinase activity
H2O74_RS09335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H2O74_RS09345	COG1845	cytochrome c oxidase, subunit III
H2O74_RS09355	COG0723	plastoquinol--plastocyanin reductase activity
H2O74_RS09360	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H2O74_RS09375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H2O74_RS09380	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H2O74_RS09385	COG1104	cysteine desulfurase activity
H2O74_RS09390	COG0425	Belongs to the sulfur carrier protein TusA family
H2O74_RS09405	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H2O74_RS09420	COG0831	urea catabolic process
H2O74_RS09430	COG0831	urea catabolic process
H2O74_RS09430	COG0832	Belongs to the urease beta subunit family
H2O74_RS09435	COG0804	urea catabolic process
H2O74_RS09440	COG0830	nickel cation binding
H2O74_RS09445	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H2O74_RS09450	COG0829	nickel cation binding
H2O74_RS09475	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H2O74_RS09480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H2O74_RS09485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H2O74_RS09495	COG0667	Aldo Keto reductase
H2O74_RS09510	COG0167	dihydroorotate dehydrogenase activity
H2O74_RS09525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H2O74_RS09535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2O74_RS09540	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2O74_RS09555	COG0673	inositol 2-dehydrogenase activity
H2O74_RS09560	COG2409	Drug exporters of the RND superfamily
H2O74_RS09570	COG0321	lipoyl(octanoyl) transferase activity
H2O74_RS09575	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H2O74_RS09630	COG4585	Histidine kinase
H2O74_RS09640	COG1063	alcohol dehydrogenase
H2O74_RS09645	COG1070	Carbohydrate kinase
H2O74_RS09655	COG1785	Belongs to the alkaline phosphatase family
H2O74_RS09660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2O74_RS09680	COG0644	oxidoreductase
H2O74_RS09690	COG2086	electron transfer activity
H2O74_RS09695	COG1960	acyl-CoA dehydrogenase activity
H2O74_RS09715	COG1796	DNA polymerase
H2O74_RS09715	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H2O74_RS09720	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H2O74_RS09730	COG3285	dna ligase
H2O74_RS09730	COG1793	dna ligase
H2O74_RS09745	COG1832	CoA-binding protein
H2O74_RS09750	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H2O74_RS09755	COG0174	glutamine synthetase
H2O74_RS09765	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H2O74_RS09775	COG1357	PFAM Pentapeptide repeats (8 copies)
H2O74_RS09805	COG0784	Response regulator, receiver
H2O74_RS09810	COG2814	Major facilitator Superfamily
H2O74_RS09820	COG3022	response to hydroperoxide
H2O74_RS09860	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H2O74_RS09880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H2O74_RS09885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2O74_RS09890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H2O74_RS09940	COG0395	ABC-type sugar transport system, permease component
H2O74_RS09945	COG1175	transmembrane transport
H2O74_RS09955	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H2O74_RS09965	COG1609	Transcriptional regulator
H2O74_RS09975	COG1175	transmembrane transport
H2O74_RS09995	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
H2O74_RS10000	COG0735	belongs to the Fur family
H2O74_RS10005	COG1454	alcohol dehydrogenase
H2O74_RS10010	COG2354	Protein conserved in bacteria
H2O74_RS10020	COG3866	Pectate lyase
H2O74_RS10030	COG0358	DNA primase activity
H2O74_RS10100	COG0366	Alpha amylase catalytic
H2O74_RS10105	COG3833	ABC-type maltose transport systems, permease component
H2O74_RS10110	COG1175	transmembrane transport
H2O74_RS10120	COG1609	Transcriptional regulator
H2O74_RS10125	COG0366	Alpha amylase catalytic
H2O74_RS10140	COG0423	glycine-tRNA ligase activity
H2O74_RS10145	COG3443	Belongs to the bacterial solute-binding protein 9 family
H2O74_RS10145	COG0803	Belongs to the bacterial solute-binding protein 9 family
H2O74_RS10150	COG1121	(ABC) transporter
H2O74_RS10155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H2O74_RS10170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H2O74_RS10175	COG1381	Involved in DNA repair and RecF pathway recombination
H2O74_RS10180	COG1162	GTPase activity
H2O74_RS10185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H2O74_RS10210	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H2O74_RS10220	COG0537	adenosine 5'-monophosphoramidase activity
H2O74_RS10235	COG0484	heat shock protein binding
H2O74_RS10240	COG1420	regulation of RNA biosynthetic process
H2O74_RS10260	COG0481	GTPase activity
H2O74_RS10265	COG1305	Transglutaminase-like
H2O74_RS10285	COG0268	Binds directly to 16S ribosomal RNA
H2O74_RS10305	COG2333	competence protein COMEC
H2O74_RS10305	COG0658	competence protein
H2O74_RS10310	COG2183	response to ionizing radiation
H2O74_RS10315	COG1307	EDD domain protein, DegV family
H2O74_RS10320	COG0495	leucyl-tRNA aminoacylation
H2O74_RS10330	COG1321	iron dependent repressor
H2O74_RS10335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H2O74_RS10340	COG1121	(ABC) transporter
H2O74_RS10375	COG1556	Lactate utilization protein
H2O74_RS10380	COG1139	Iron-sulfur cluster binding protein
H2O74_RS10385	COG0247	lactate metabolic process
H2O74_RS10400	COG0799	negative regulation of ribosome biogenesis
H2O74_RS10410	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H2O74_RS10420	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H2O74_RS10435	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H2O74_RS10440	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H2O74_RS10445	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H2O74_RS10450	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H2O74_RS10460	COG1530	ribonuclease E activity
H2O74_RS10465	COG1271	oxidase subunit
H2O74_RS10470	COG1294	oxidase, subunit
H2O74_RS10475	COG4988	ABC transporter
H2O74_RS10480	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H2O74_RS10495	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H2O74_RS10500	COG0571	ribonuclease III activity
H2O74_RS10505	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H2O74_RS10520	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H2O74_RS10525	COG0742	ribosomal rna small subunit methyltransferase
H2O74_RS10535	COG1461	Dihydroxyacetone kinase
H2O74_RS10540	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H2O74_RS10560	COG1181	Belongs to the D-alanine--D-alanine ligase family
H2O74_RS10565	COG1181	Belongs to the D-alanine--D-alanine ligase family
H2O74_RS10570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H2O74_RS10575	COG0596	Alpha beta hydrolase
H2O74_RS10585	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H2O74_RS10595	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H2O74_RS10600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2O74_RS10605	COG0066	3-isopropylmalate dehydratase activity
H2O74_RS10610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H2O74_RS10615	COG1414	Transcriptional regulator
H2O74_RS10645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H2O74_RS10670	COG2226	methyltransferase
H2O74_RS10675	COG0328	RNA-DNA hybrid ribonuclease activity
H2O74_RS10700	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H2O74_RS10705	COG3304	Inner membrane component domain
H2O74_RS10710	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H2O74_RS10715	COG1132	(ABC) transporter
H2O74_RS10725	COG0435	Glutathione S-transferase
H2O74_RS10735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H2O74_RS10740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H2O74_RS10745	COG0473	3-isopropylmalate dehydrogenase activity
H2O74_RS10750	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H2O74_RS10755	COG0440	acetolactate synthase activity
H2O74_RS10760	COG1794	racemase activity, acting on amino acids and derivatives
H2O74_RS10785	COG2124	cytochrome p450
H2O74_RS10790	COG1216	Glycosyl transferase, family 2
H2O74_RS10795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H2O74_RS10825	COG0714	Associated with various cellular activities
H2O74_RS10865	COG0129	dihydroxy-acid dehydratase activity
H2O74_RS10870	COG2154	pterin-4-alpha-carbinolamine dehydratase
H2O74_RS10880	COG1472	Belongs to the glycosyl hydrolase 3 family
H2O74_RS10885	COG0395	ABC-type sugar transport system, permease component
H2O74_RS10890	COG1175	transmembrane transport
H2O74_RS10905	COG3104	oligopeptide transport
H2O74_RS10925	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H2O74_RS10930	COG0154	amidase activity
H2O74_RS10935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H2O74_RS10945	COG2197	response regulator
H2O74_RS10950	COG2311	Membrane
H2O74_RS10970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H2O74_RS10980	COG0482	sulfurtransferase activity
H2O74_RS11020	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H2O74_RS11025	COG2086	electron transfer activity
H2O74_RS11045	COG0366	Alpha amylase catalytic
H2O74_RS11055	COG3281	Trehalose synthase
H2O74_RS11060	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H2O74_RS11090	COG0596	Alpha beta hydrolase
H2O74_RS11100	COG0561	phosphatase activity
H2O74_RS11120	COG0259	pyridoxamine-phosphate oxidase activity
H2O74_RS11125	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
H2O74_RS11135	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H2O74_RS11140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H2O74_RS11145	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H2O74_RS11150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H2O74_RS11155	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H2O74_RS11160	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H2O74_RS11165	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H2O74_RS11170	COG0356	it plays a direct role in the translocation of protons across the membrane
H2O74_RS11180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H2O74_RS11190	COG2890	protein-(glutamine-N5) methyltransferase activity
H2O74_RS11195	COG0254	rRNA binding
H2O74_RS11205	COG0083	homoserine kinase activity
H2O74_RS11210	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H2O74_RS11215	COG0460	homoserine dehydrogenase
H2O74_RS11225	COG0018	arginyl-trna synthetase
H2O74_RS11235	COG2186	Transcriptional regulator
H2O74_RS11320	COG0513	Belongs to the DEAD box helicase family
H2O74_RS11325	COG1002	Type II restriction enzyme, methylase subunits
H2O74_RS11340	COG2963	transposase activity
H2O74_RS11360	COG4591	ABC-type transport system involved in lipoprotein release permease component
H2O74_RS11360	COG1136	(ABC) transporter
H2O74_RS11390	COG1012	belongs to the aldehyde dehydrogenase family
H2O74_RS11390	COG1454	alcohol dehydrogenase
H2O74_RS11415	COG1253	flavin adenine dinucleotide binding
H2O74_RS11420	COG0745	RESPONSE REGULATOR receiver
H2O74_RS11425	COG2205	protein histidine kinase activity
H2O74_RS11440	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2O74_RS11440	COG0567	Dehydrogenase, E1 component
H2O74_RS11470	COG1595	DNA-templated transcription, initiation
H2O74_RS11480	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H2O74_RS11485	COG1162	GTPase activity
H2O74_RS11490	COG0483	inositol monophosphate 1-phosphatase activity
H2O74_RS11535	COG0653	protein targeting
H2O74_RS11540	COG3214	Protein conserved in bacteria
H2O74_RS11545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H2O74_RS11555	COG5401	PFAM Sporulation and spore germination
H2O74_RS11560	COG5002	protein histidine kinase activity
H2O74_RS11565	COG0745	RESPONSE REGULATOR receiver
H2O74_RS11615	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H2O74_RS11620	COG4175	Glycine betaine
H2O74_RS11620	COG3448	diguanylate cyclase activity
H2O74_RS11635	COG2835	tetraacyldisaccharide 4'-kinase activity
H2O74_RS11640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H2O74_RS11685	COG1482	cell wall glycoprotein biosynthetic process
H2O74_RS11690	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H2O74_RS11695	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H2O74_RS11710	COG0463	Glycosyl transferase, family 2
H2O74_RS11725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H2O74_RS11735	COG0463	Glycosyl transferase, family 2
H2O74_RS11750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H2O74_RS11755	COG1086	Polysaccharide biosynthesis protein
H2O74_RS11760	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
H2O74_RS11770	COG2089	acid synthase
H2O74_RS11785	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H2O74_RS11810	COG1216	Glycosyl transferase, family 2
H2O74_RS11825	COG2247	cell wall binding repeat
H2O74_RS11825	COG2385	sporulation resulting in formation of a cellular spore
H2O74_RS11840	COG0438	transferase activity, transferring glycosyl groups
H2O74_RS11840	COG1216	Glycosyl transferase, family 2
H2O74_RS11860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H2O74_RS11870	COG1088	dTDP-glucose 4,6-dehydratase activity
H2O74_RS11880	COG1316	TRANSCRIPTIONal
H2O74_RS11885	COG1316	TRANSCRIPTIONal
H2O74_RS11910	COG2205	protein histidine kinase activity
H2O74_RS11915	COG0745	RESPONSE REGULATOR receiver
H2O74_RS11920	COG4585	Histidine kinase
H2O74_RS11930	COG4591	ABC-type transport system involved in lipoprotein release permease component
H2O74_RS11930	COG1136	(ABC) transporter
H2O74_RS11980	COG0577	efflux transmembrane transporter activity
H2O74_RS11980	COG1136	(ABC) transporter
H2O74_RS11985	COG1136	(ABC) transporter
H2O74_RS12005	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H2O74_RS12020	COG3300	MHYT domain
H2O74_RS12020	COG5001	Diguanylate cyclase
H2O74_RS12025	COG2514	catechol 2,3-dioxygenase activity
H2O74_RS12050	COG1140	nitrate reductase beta subunit
H2O74_RS12070	COG0315	cyclic pyranopterin monophosphate synthase activity
H2O74_RS12070	COG0521	Mo-molybdopterin cofactor biosynthetic process
H2O74_RS12080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H2O74_RS12095	COG0315	cyclic pyranopterin monophosphate synthase activity
H2O74_RS12130	COG3842	ATPase activity
H2O74_RS12145	COG1295	ribonuclease BN
H2O74_RS12160	COG1175	transmembrane transport
H2O74_RS12165	COG0395	ABC-type sugar transport system, permease component
H2O74_RS12170	COG2723	6-phospho-beta-galactosidase activity
H2O74_RS12200	COG2340	Cysteine-rich secretory protein family
H2O74_RS12225	COG0438	transferase activity, transferring glycosyl groups
H2O74_RS12230	COG0438	transferase activity, transferring glycosyl groups
H2O74_RS12240	COG0489	protein tyrosine kinase activity
H2O74_RS12270	COG0446	pyridine nucleotide-disulphide oxidoreductase
H2O74_RS12275	COG1937	Protein conserved in bacteria
H2O74_RS12280	COG0076	glutamate decarboxylase activity
H2O74_RS12285	COG0531	amino acid
H2O74_RS12290	COG1331	Highly conserved protein containing a thioredoxin domain
H2O74_RS12305	COG0395	ABC-type sugar transport system, permease component
H2O74_RS12310	COG1175	transmembrane transport
H2O74_RS12400	COG2226	methyltransferase
H2O74_RS12425	COG1506	peptidase
H2O74_RS12425	COG0823	Involved in the tonB-independent uptake of proteins
H2O74_RS12425	COG4946	Tricorn protease homolog
H2O74_RS12430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H2O74_RS12435	COG1793	dna ligase
H2O74_RS12475	COG2409	Drug exporters of the RND superfamily
H2O74_RS12480	COG0277	FAD linked oxidase domain protein
H2O74_RS12495	COG1678	Uncharacterized ACR, COG1678
H2O74_RS12500	COG3546	catalase activity
H2O74_RS12515	COG0577	efflux transmembrane transporter activity
H2O74_RS12515	COG1136	(ABC) transporter
H2O74_RS12520	COG2197	response regulator
H2O74_RS12540	COG3507	Belongs to the glycosyl hydrolase 43 family
H2O74_RS12555	COG4209	transmembrane transport
H2O74_RS12560	COG0395	ABC-type sugar transport system, permease component
H2O74_RS12580	COG1615	UPF0182 protein
H2O74_RS12590	COG3480	Lon protease (S16) C-terminal proteolytic domain
H2O74_RS12685	COG0513	Belongs to the DEAD box helicase family
H2O74_RS12700	COG2095	MarC family integral membrane protein
H2O74_RS12710	COG0006	proline dipeptidase activity
H2O74_RS12720	COG2239	Acts as a magnesium transporter
H2O74_RS12735	COG1349	DNA-binding transcription factor activity
H2O74_RS12745	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H2O74_RS12760	COG1136	(ABC) transporter
H2O74_RS12765	COG0577	efflux transmembrane transporter activity
H2O74_RS12785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H2O74_RS12790	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H2O74_RS12815	COG4214	carbohydrate transport
H2O74_RS12825	COG4213	ABC transporter substrate-binding protein
H2O74_RS12830	COG1940	carbohydrate kinase activity
H2O74_RS12830	COG1846	Transcriptional regulator
H2O74_RS12845	COG1802	Transcriptional regulator
H2O74_RS12860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2O74_RS12890	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H2O74_RS12895	COG1872	DUF167
H2O74_RS12905	COG0039	L-malate dehydrogenase activity
H2O74_RS12925	COG0138	bifunctional purine biosynthesis protein purh
H2O74_RS12950	COG0045	succinate-CoA ligase (ADP-forming) activity
H2O74_RS12980	COG2197	response regulator
H2O74_RS13005	COG0438	transferase activity, transferring glycosyl groups
H2O74_RS13015	COG0519	Catalyzes the synthesis of GMP from XMP
H2O74_RS13015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H2O74_RS13035	COG1132	(ABC) transporter
H2O74_RS13040	COG1132	(ABC) transporter
H2O74_RS13060	COG2318	DinB family
H2O74_RS13065	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H2O74_RS13075	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H2O74_RS13085	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H2O74_RS13090	COG1012	belongs to the aldehyde dehydrogenase family
H2O74_RS13095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H2O74_RS13100	COG1105	Belongs to the carbohydrate kinase PfkB family
H2O74_RS13105	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2O74_RS13110	COG2213	PTS system mannitol-specific
H2O74_RS13115	COG1063	alcohol dehydrogenase
H2O74_RS13120	COG1349	DNA-binding transcription factor activity
H2O74_RS13125	COG0516	GMP reductase activity
H2O74_RS13130	COG0693	protein deglycase activity
H2O74_RS13140	COG0483	inositol monophosphate 1-phosphatase activity
H2O74_RS13150	COG2197	response regulator
H2O74_RS13165	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H2O74_RS13175	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H2O74_RS13190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H2O74_RS13195	COG0456	acetyltransferase
H2O74_RS13200	COG1214	PFAM Peptidase M22, glycoprotease
H2O74_RS13200	COG0456	acetyltransferase
H2O74_RS13205	COG0802	atpase or kinase
H2O74_RS13210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H2O74_RS13230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2O74_RS13235	COG0736	holo-[acyl-carrier-protein] synthase activity
H2O74_RS13240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H2O74_RS13245	COG1072	(Pantothenic acid kinase))
H2O74_RS13255	COG0242	peptide deformylase activity
H2O74_RS13260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H2O74_RS13265	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H2O74_RS13270	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H2O74_RS13295	COG0488	(ABC) transporter
H2O74_RS13305	COG0101	tRNA pseudouridine synthase activity
H2O74_RS13315	COG0203	ribosomal protein L17
H2O74_RS13320	COG0202	RNA polymerase activity
H2O74_RS13325	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H2O74_RS13330	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H2O74_RS13335	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H2O74_RS13340	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H2O74_RS13350	COG0563	adenylate kinase activity
H2O74_RS13355	COG0201	protein transport
H2O74_RS13360	COG0200	Binds to the 23S rRNA
H2O74_RS13365	COG1841	ribosomal large subunit assembly
H2O74_RS13370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H2O74_RS13380	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H2O74_RS13385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H2O74_RS13390	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H2O74_RS13395	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H2O74_RS13400	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H2O74_RS13405	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H2O74_RS13410	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H2O74_RS13415	COG0255	Belongs to the universal ribosomal protein uL29 family
H2O74_RS13420	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H2O74_RS13425	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H2O74_RS13430	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H2O74_RS13435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H2O74_RS13440	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H2O74_RS13445	COG0089	rRNA binding
H2O74_RS13450	COG0088	Forms part of the polypeptide exit tunnel
H2O74_RS13455	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H2O74_RS13460	COG0051	transcription antitermination factor activity, RNA binding
H2O74_RS13465	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H2O74_RS13470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H2O74_RS13475	COG0049	tRNA binding
H2O74_RS13480	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H2O74_RS13485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H2O74_RS13490	COG0085	RNA polymerase activity
H2O74_RS13495	COG0222	ribosome binding
H2O74_RS13500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H2O74_RS13505	COG0081	regulation of translation
H2O74_RS13510	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H2O74_RS13530	COG0436	Aminotransferase
H2O74_RS13535	COG1131	(ABC) transporter
H2O74_RS13545	COG3851	Histidine kinase
H2O74_RS13555	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H2O74_RS13565	COG1725	Transcriptional regulator
H2O74_RS13575	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H2O74_RS13580	COG0738	Major facilitator superfamily
H2O74_RS13600	COG2030	dehydratase
H2O74_RS13605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H2O74_RS13620	COG1666	GTP binding
H2O74_RS13630	COG0501	Belongs to the peptidase M48B family
H2O74_RS13635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2O74_RS13640	COG0765	amino acid transport
H2O74_RS13715	COG1674	ftsk spoiiie
H2O74_RS13720	COG1131	(ABC) transporter
H2O74_RS13730	COG1305	Transglutaminase-like
H2O74_RS13740	COG0714	Associated with various cellular activities
H2O74_RS13770	COG1007	ATP synthesis coupled electron transport
H2O74_RS13780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H2O74_RS13785	COG0713	ATP synthesis coupled electron transport
H2O74_RS13790	COG0839	Belongs to the complex I subunit 6 family
H2O74_RS13795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2O74_RS13800	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H2O74_RS13805	COG1034	ATP synthesis coupled electron transport
H2O74_RS13820	COG0649	NAD binding
H2O74_RS13830	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2O74_RS13845	COG2226	methyltransferase
H2O74_RS13850	COG1169	isochorismate synthase
H2O74_RS13855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2O74_RS13860	COG0534	Mate efflux family protein
H2O74_RS13865	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H2O74_RS13870	COG4948	Mandelate Racemase Muconate Lactonizing
H2O74_RS13875	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H2O74_RS13885	COG1470	cell adhesion involved in biofilm formation
H2O74_RS13895	COG1575	Belongs to the MenA family. Type 1 subfamily
H2O74_RS13915	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H2O74_RS13920	COG1333	cytochrome c biogenesis protein
H2O74_RS13925	COG0785	Cytochrome C biogenesis protein
H2O74_RS13935	COG0406	alpha-ribazole phosphatase activity
H2O74_RS13945	COG2353	YceI-like domain
H2O74_RS13950	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
H2O74_RS13975	COG0123	including yeast histone deacetylase and acetoin utilization protein
H2O74_RS13980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H2O74_RS13985	COG0569	domain protein
H2O74_RS13990	COG1172	Belongs to the binding-protein-dependent transport system permease family
H2O74_RS13995	COG1172	Belongs to the binding-protein-dependent transport system permease family
H2O74_RS14000	COG1879	ABC-type sugar transport system periplasmic component
H2O74_RS14005	COG4214	carbohydrate transport
H2O74_RS14015	COG4213	ABC transporter substrate-binding protein
H2O74_RS14025	COG2160	L-arabinose isomerase activity
H2O74_RS14040	COG1609	Transcriptional regulator
H2O74_RS14045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H2O74_RS14055	COG0842	Transport permease protein
H2O74_RS14070	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H2O74_RS14075	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
H2O74_RS14090	COG1194	a g-specific adenine glycosylase
H2O74_RS14095	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
H2O74_RS14100	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H2O74_RS14140	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H2O74_RS14145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H2O74_RS14150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H2O74_RS14155	COG1846	Transcriptional regulator
H2O74_RS14160	COG0697	spore germination
H2O74_RS14165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2O74_RS14170	COG0395	ABC-type sugar transport system, permease component
H2O74_RS14180	COG3842	ATPase activity
H2O74_RS14190	COG1609	Transcriptional regulator
H2O74_RS14195	COG4948	Mandelate Racemase Muconate Lactonizing
H2O74_RS14210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2O74_RS14215	COG0800	Aldolase
H2O74_RS14220	COG1414	Transcriptional regulator
H2O74_RS14230	COG4948	Mandelate Racemase Muconate Lactonizing
H2O74_RS14235	COG2186	Transcriptional regulator
H2O74_RS14240	COG1028	Short-chain dehydrogenase reductase Sdr
H2O74_RS14255	COG1028	Short-chain dehydrogenase reductase Sdr
H2O74_RS14260	COG1414	Transcriptional regulator
H2O74_RS14265	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H2O74_RS14275	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H2O74_RS14290	COG2084	Dehydrogenase
H2O74_RS14295	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H2O74_RS14330	COG5278	phosphoserine phosphatase activity
H2O74_RS14330	COG0840	transmembrane signaling receptor activity
H2O74_RS14345	COG2223	nitrite transmembrane transporter activity
H2O74_RS14355	COG0110	maltose O-acetyltransferase activity
H2O74_RS14370	COG0673	inositol 2-dehydrogenase activity
H2O74_RS14380	COG0395	ABC-type sugar transport system, permease component
H2O74_RS14385	COG1175	transmembrane transport
H2O74_RS14390	COG0673	inositol 2-dehydrogenase activity
H2O74_RS14400	COG2721	sulfolactate sulfo-lyase activity
H2O74_RS14410	COG1904	glucuronate isomerase
H2O74_RS14415	COG1609	Transcriptional regulator
H2O74_RS14420	COG0246	Mannitol dehydrogenase
H2O74_RS14425	COG0673	inositol 2-dehydrogenase activity
H2O74_RS14475	COG0514	ATP-dependent DNA helicase (RecQ)
H2O74_RS14485	COG0673	inositol 2-dehydrogenase activity
H2O74_RS14505	COG4941	Belongs to the sigma-70 factor family
H2O74_RS14520	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H2O74_RS14520	COG4447	cellulose binding
H2O74_RS14525	COG1668	transmembrane transport
H2O74_RS14530	COG4152	abc transporter atp-binding protein
H2O74_RS14535	COG2197	response regulator
H2O74_RS14540	COG4585	Histidine kinase
H2O74_RS14540	COG2203	Gaf domain
H2O74_RS14550	COG1070	Carbohydrate kinase
H2O74_RS14555	COG3347	Dehydrogenase
H2O74_RS14555	COG1028	Short-chain dehydrogenase reductase Sdr
H2O74_RS14565	COG3254	rhamnose metabolic process
H2O74_RS14570	COG1609	Transcriptional regulator
H2O74_RS14595	COG0667	Aldo Keto reductase
H2O74_RS14600	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H2O74_RS14640	COG3458	cephalosporin-C deacetylase activity
H2O74_RS14645	COG0187	DNA topoisomerase II activity
H2O74_RS14660	COG2267	carboxylic ester hydrolase activity
H2O74_RS14675	COG1476	TRANSCRIPTIONal
H2O74_RS14690	COG0667	Aldo Keto reductase
H2O74_RS14695	COG1490	D-aminoacyl-tRNA deacylase activity
H2O74_RS14715	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H2O74_RS14720	COG3485	protocatechuate 3,4-dioxygenase
H2O74_RS14735	COG0745	RESPONSE REGULATOR receiver
H2O74_RS14740	COG2267	carboxylic ester hydrolase activity
H2O74_RS14770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H2O74_RS14775	COG1408	metallophosphoesterase
H2O74_RS14795	COG1131	(ABC) transporter
H2O74_RS14810	COG1131	(ABC) transporter
H2O74_RS14845	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H2O74_RS14860	COG1136	(ABC) transporter
H2O74_RS14870	COG0640	Transcriptional regulator
H2O74_RS14875	COG0346	lactoylglutathione lyase activity
H2O74_RS14935	COG2116	formate transmembrane transporter activity
H2O74_RS14945	COG1966	Carbon starvation protein
H2O74_RS14950	COG1131	(ABC) transporter
H2O74_RS14985	COG1120	ATPase activity
H2O74_RS14990	COG2610	gluconate transmembrane transporter activity
H2O74_RS14995	COG3265	gluconokinase activity
H2O74_RS15010	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H2O74_RS15015	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H2O74_RS15020	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H2O74_RS15035	COG0697	spore germination
H2O74_RS15050	COG0456	acetyltransferase
H2O74_RS15055	COG2233	PERMEase
H2O74_RS15085	COG1464	Belongs to the NlpA lipoprotein family
H2O74_RS15090	COG2011	ABC-type metal ion transport system permease component
H2O74_RS15095	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H2O74_RS15100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H2O74_RS15110	COG0659	secondary active sulfate transmembrane transporter activity
H2O74_RS15120	COG0778	Nitroreductase
H2O74_RS15135	COG1063	alcohol dehydrogenase
H2O74_RS15205	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H2O74_RS15210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H2O74_RS15210	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H2O74_RS15215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H2O74_RS15225	COG2011	ABC-type metal ion transport system permease component
H2O74_RS15230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H2O74_RS15250	COG1233	COG1233 Phytoene dehydrogenase and related
H2O74_RS15270	COG0463	Glycosyl transferase, family 2
H2O74_RS15280	COG0702	epimerase
H2O74_RS15295	COG0789	Transcriptional regulator
H2O74_RS15300	COG0484	heat shock protein binding
H2O74_RS15305	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H2O74_RS15310	COG0443	Heat shock 70 kDa protein
H2O74_RS15355	COG2267	carboxylic ester hydrolase activity
H2O74_RS15365	COG3250	beta-galactosidase activity
H2O74_RS15400	COG1278	Cold shock
H2O74_RS15410	COG1595	DNA-templated transcription, initiation
H2O74_RS15435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H2O74_RS15485	COG2200	EAL domain
H2O74_RS15485	COG2199	diguanylate cyclase activity
H2O74_RS15510	COG3795	YCII-related domain
H2O74_RS15515	COG4941	Belongs to the sigma-70 factor family
H2O74_RS15520	COG1309	transcriptional regulator
H2O74_RS15550	COG3842	ATPase activity
H2O74_RS15555	COG1178	ABC-type Fe3 transport system permease component
H2O74_RS15610	COG2111	Na H antiporter
H2O74_RS15610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H2O74_RS15615	COG0247	lactate metabolic process
H2O74_RS15615	COG2181	nitrate reductase activity
H2O74_RS15625	COG0717	Belongs to the dCTP deaminase family
H2O74_RS15655	COG1136	(ABC) transporter
H2O74_RS15660	COG2755	lipolytic protein G-D-S-L family
H2O74_RS15670	COG1609	Transcriptional regulator
H2O74_RS15680	COG0395	ABC-type sugar transport system, permease component
H2O74_RS15695	COG1653	transport
H2O74_RS15700	COG5578	integral membrane protein
H2O74_RS15705	COG4209	transmembrane transport
H2O74_RS15710	COG0657	acetylesterase activity
H2O74_RS15710	COG2755	lipolytic protein G-D-S-L family
H2O74_RS15755	COG1058	Belongs to the CinA family
H2O74_RS15755	COG1546	Belongs to the CinA family
H2O74_RS15785	COG2378	regulation of single-species biofilm formation
H2O74_RS15855	COG0714	Associated with various cellular activities
H2O74_RS15895	COG0464	growth
H2O74_RS15905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2O74_RS15915	COG0515	serine threonine protein kinase
H2O74_RS15930	COG1716	ATPase activity
H2O74_RS15935	COG2081	HI0933 family
H2O74_RS15950	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2O74_RS15955	COG0022	dehydrogenase e1 component
H2O74_RS15975	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H2O74_RS15980	COG1950	PFAM Membrane protein of
H2O74_RS16015	COG0714	Associated with various cellular activities
H2O74_RS16050	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H2O74_RS16060	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H2O74_RS16065	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H2O74_RS16085	COG0181	hydroxymethylbilane synthase activity
H2O74_RS16095	COG0113	porphobilinogen synthase activity
H2O74_RS16100	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H2O74_RS16115	COG0366	Alpha amylase catalytic
H2O74_RS16120	COG1937	Protein conserved in bacteria
H2O74_RS16140	COG1131	(ABC) transporter
H2O74_RS16170	COG2076	Multidrug Resistance protein
H2O74_RS16185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2O74_RS16190	COG0640	Transcriptional regulator
H2O74_RS16220	COG0640	Transcriptional regulator
H2O74_RS16240	COG4585	Histidine kinase
H2O74_RS16245	COG2197	response regulator
H2O74_RS16265	COG0789	Transcriptional regulator
H2O74_RS16265	COG4978	Transcriptional regulator
H2O74_RS16275	COG2267	carboxylic ester hydrolase activity
H2O74_RS16290	COG0305	Participates in initiation and elongation during chromosome replication
H2O74_RS16300	COG0359	binds to the 23S rRNA
H2O74_RS16305	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H2O74_RS16315	COG0360	Binds together with S18 to 16S ribosomal RNA
H2O74_RS16320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H2O74_RS16330	COG1260	myo-inositol-1-phosphate synthase
H2O74_RS16340	COG0702	epimerase
H2O74_RS16345	COG3706	GGDEF domain
H2O74_RS16355	COG0784	Response regulator, receiver
H2O74_RS16355	COG4191	Histidine kinase
H2O74_RS16365	COG0617	tRNA 3'-terminal CCA addition
H2O74_RS16390	COG3118	belongs to the thioredoxin family
H2O74_RS16395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2O74_RS16405	COG1192	Involved in chromosome partitioning
H2O74_RS16410	COG0357	Ribosomal RNA small subunit methyltransferase G
H2O74_RS16420	COG0706	membrane insertase activity
H2O74_RS16425	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H2O74_RS16430	COG0594	ribonuclease P activity
H2O74_RS16435	COG0230	Belongs to the bacterial ribosomal protein bL34 family