locus-tag	class	description
DDD63_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DDD63_RS00010	COG0592	DNA-directed DNA polymerase activity
DDD63_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DDD63_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DDD63_RS00025	COG0187	DNA topoisomerase II activity
DDD63_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DDD63_RS00060	COG2814	Major facilitator Superfamily
DDD63_RS00080	COG1113	amino acid transport
DDD63_RS00090	COG2376	Dihydroxyacetone kinase
DDD63_RS00095	COG1063	alcohol dehydrogenase
DDD63_RS00120	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DDD63_RS00125	COG0604	alcohol dehydrogenase
DDD63_RS00150	COG3764	Sortase (surface protein transpeptidase)
DDD63_RS00165	COG0768	penicillin binding
DDD63_RS00180	COG1716	ATPase activity
DDD63_RS00185	COG0842	Transport permease protein
DDD63_RS00185	COG1131	(ABC) transporter
DDD63_RS00185	COG1716	ATPase activity
DDD63_RS00200	COG0626	cystathionine gamma-synthase activity
DDD63_RS00210	COG1132	(ABC) transporter
DDD63_RS00215	COG1132	(ABC) transporter
DDD63_RS00255	COG2801	Transposase and inactivated derivatives
DDD63_RS00300	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DDD63_RS00305	COG1854	S-ribosylhomocysteine lyase activity
DDD63_RS00335	COG1780	Probably involved in ribonucleotide reductase function
DDD63_RS00340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DDD63_RS00390	COG0471	metal ion transport
DDD63_RS00420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DDD63_RS00430	COG2095	MarC family integral membrane protein
DDD63_RS00515	COG1643	Atp-dependent helicase
DDD63_RS00520	COG0438	transferase activity, transferring glycosyl groups
DDD63_RS00525	COG0438	transferase activity, transferring glycosyl groups
DDD63_RS00530	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DDD63_RS00615	COG1454	alcohol dehydrogenase
DDD63_RS00650	COG2610	gluconate transmembrane transporter activity
DDD63_RS00655	COG4948	Mandelate Racemase Muconate Lactonizing
DDD63_RS00660	COG2084	Dehydrogenase
DDD63_RS00665	COG4948	Mandelate Racemase Muconate Lactonizing
DDD63_RS00670	COG1929	Belongs to the glycerate kinase type-1 family
DDD63_RS00735	COG1136	(ABC) transporter
DDD63_RS00770	COG1643	Atp-dependent helicase
DDD63_RS00775	COG0254	rRNA binding
DDD63_RS00780	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DDD63_RS00785	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DDD63_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DDD63_RS00810	COG1121	(ABC) transporter
DDD63_RS00815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DDD63_RS00840	COG1285	pathogenesis
DDD63_RS00875	COG0745	RESPONSE REGULATOR receiver
DDD63_RS00880	COG5002	protein histidine kinase activity
DDD63_RS00880	COG3850	Histidine kinase
DDD63_RS00895	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DDD63_RS00905	COG0463	Glycosyl transferase, family 2
DDD63_RS00920	COG0077	Prephenate dehydratase
DDD63_RS00930	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DDD63_RS00935	COG0561	phosphatase activity
DDD63_RS00960	COG0009	L-threonylcarbamoyladenylate synthase
DDD63_RS01010	COG0222	ribosome binding
DDD63_RS01045	COG1518	maintenance of DNA repeat elements
DDD63_RS01060	COG1857	crispr-associated protein
DDD63_RS01080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DDD63_RS01115	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DDD63_RS01120	COG3304	Inner membrane component domain
DDD63_RS01145	COG1131	(ABC) transporter
DDD63_RS01150	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DDD63_RS01160	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DDD63_RS01165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DDD63_RS01165	COG0519	Catalyzes the synthesis of GMP from XMP
DDD63_RS01170	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DDD63_RS01225	COG0596	Alpha beta hydrolase
DDD63_RS01275	COG1205	dead DEAH box helicase
DDD63_RS01275	COG1111	helicase
DDD63_RS01300	COG2264	protein methyltransferase activity
DDD63_RS01305	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DDD63_RS01315	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DDD63_RS01350	COG0588	phosphoglycerate mutase activity
DDD63_RS01360	COG1329	Transcriptional regulator
DDD63_RS01365	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DDD63_RS01370	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DDD63_RS01375	COG0215	cysteine-tRNA ligase activity
DDD63_RS01380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DDD63_RS01435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DDD63_RS01455	COG3842	ATPase activity
DDD63_RS01460	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DDD63_RS01460	COG0515	serine threonine protein kinase
DDD63_RS01500	COG1136	(ABC) transporter
DDD63_RS01500	COG0577	efflux transmembrane transporter activity
DDD63_RS01505	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DDD63_RS01520	COG0459	protein refolding
DDD63_RS01560	COG1028	Short-chain dehydrogenase reductase Sdr
DDD63_RS01570	COG2205	protein histidine kinase activity
DDD63_RS01575	COG0745	RESPONSE REGULATOR receiver
DDD63_RS01580	COG1842	Phage shock protein A
DDD63_RS01590	COG1278	Cold shock
DDD63_RS01605	COG2252	PERMEase
DDD63_RS01615	COG2814	Major facilitator Superfamily
DDD63_RS01625	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DDD63_RS01640	COG0791	NLP P60 protein
DDD63_RS01640	COG1388	LysM domain
DDD63_RS01675	COG1970	mechanosensitive ion channel activity
DDD63_RS01690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DDD63_RS01755	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DDD63_RS01825	COG1028	Short-chain dehydrogenase reductase Sdr
DDD63_RS01835	COG1131	(ABC) transporter
DDD63_RS01895	COG0789	Transcriptional regulator
DDD63_RS01900	COG1131	(ABC) transporter
DDD63_RS01935	COG1082	Xylose isomerase domain protein TIM barrel
DDD63_RS01950	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DDD63_RS01955	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DDD63_RS01960	COG1233	COG1233 Phytoene dehydrogenase and related
DDD63_RS01970	COG0113	porphobilinogen synthase activity
DDD63_RS01975	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DDD63_RS01990	COG1715	Restriction endonuclease
DDD63_RS02015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DDD63_RS02035	COG4989	oxidoreductase activity
DDD63_RS02040	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DDD63_RS02045	COG2390	Transcriptional regulator
DDD63_RS02050	COG1454	alcohol dehydrogenase
DDD63_RS02055	COG1070	Carbohydrate kinase
DDD63_RS02060	COG1070	Carbohydrate kinase
DDD63_RS02070	COG5564	TIM-barrel signal transduction protein
DDD63_RS02090	COG2188	Transcriptional regulator
DDD63_RS02095	COG1012	belongs to the aldehyde dehydrogenase family
DDD63_RS02105	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DDD63_RS02175	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DDD63_RS02180	COG1120	ATPase activity
DDD63_RS02185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DDD63_RS02190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDD63_RS02270	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DDD63_RS02290	COG1140	nitrate reductase beta subunit
DDD63_RS02325	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DDD63_RS02345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DDD63_RS02350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DDD63_RS02355	COG2197	response regulator
DDD63_RS02370	COG1131	(ABC) transporter
DDD63_RS02375	COG1012	belongs to the aldehyde dehydrogenase family
DDD63_RS02410	COG1335	isochorismatase
DDD63_RS02420	COG0084	hydrolase, TatD family'
DDD63_RS02435	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DDD63_RS02445	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DDD63_RS02450	COG0488	(ABC) transporter
DDD63_RS02455	COG2390	Transcriptional regulator
DDD63_RS02460	COG1070	Carbohydrate kinase
DDD63_RS02470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DDD63_RS02475	COG1668	transmembrane transport
DDD63_RS02480	COG4152	abc transporter atp-binding protein
DDD63_RS02525	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DDD63_RS02560	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DDD63_RS02565	COG0193	aminoacyl-tRNA hydrolase activity
DDD63_RS02605	COG0277	FAD linked oxidase domain protein
DDD63_RS02625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DDD63_RS02660	COG1131	(ABC) transporter
DDD63_RS02690	COG0545	Peptidyl-prolyl cis-trans isomerase
DDD63_RS02700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DDD63_RS02705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DDD63_RS02710	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DDD63_RS02715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DDD63_RS02725	COG0363	glucosamine-6-phosphate deaminase activity
DDD63_RS02730	COG2326	polyphosphate kinase activity
DDD63_RS02740	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DDD63_RS02775	COG1322	Protein conserved in bacteria
DDD63_RS02790	COG0012	GTP binding
DDD63_RS02815	COG1487	ribonuclease activity
DDD63_RS02825	COG2304	oxidoreductase activity
DDD63_RS02885	COG3311	Transcriptional regulator
DDD63_RS02905	COG1196	nuclear chromosome segregation
DDD63_RS02935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DDD63_RS02940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DDD63_RS02955	COG4989	oxidoreductase activity
DDD63_RS02980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DDD63_RS03000	COG1114	Component of the transport system for branched-chain amino acids
DDD63_RS03035	COG1113	amino acid transport
DDD63_RS03055	COG0733	neurotransmitter:sodium symporter activity
DDD63_RS03095	COG1966	Carbon starvation protein
DDD63_RS03100	COG1301	dicarboxylic acid transport
DDD63_RS03105	COG1113	amino acid transport
DDD63_RS03110	COG1022	Amp-dependent synthetase and ligase
DDD63_RS03140	COG1131	(ABC) transporter
DDD63_RS03165	COG1362	aminopeptidase activity
DDD63_RS03170	COG0318	PFAM AMP-dependent synthetase and ligase
DDD63_RS03180	COG0601	transmembrane transport
DDD63_RS03200	COG1217	gtp-binding protein TYPA
DDD63_RS03230	COG2171	N-acyltransferase activity
DDD63_RS03260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DDD63_RS03265	COG1316	TRANSCRIPTIONal
DDD63_RS03275	COG1316	TRANSCRIPTIONal
DDD63_RS03290	COG1088	dTDP-glucose 4,6-dehydratase activity
DDD63_RS03295	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DDD63_RS03315	COG0463	Glycosyl transferase, family 2
DDD63_RS03345	COG3754	Rhamnan synthesis protein F
DDD63_RS03355	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DDD63_RS03400	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DDD63_RS03440	COG0745	RESPONSE REGULATOR receiver
DDD63_RS03445	COG5002	protein histidine kinase activity
DDD63_RS03450	COG5002	protein histidine kinase activity
DDD63_RS03470	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DDD63_RS03480	COG1666	GTP binding
DDD63_RS03515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DDD63_RS03525	COG0436	Aminotransferase
DDD63_RS03535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DDD63_RS03540	COG0250	Participates in transcription elongation, termination and antitermination
DDD63_RS03545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DDD63_RS03550	COG0081	regulation of translation
DDD63_RS03565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DDD63_RS03575	COG0085	RNA polymerase activity
DDD63_RS03580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DDD63_RS03585	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DDD63_RS03590	COG0049	tRNA binding
DDD63_RS03595	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DDD63_RS03600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DDD63_RS03605	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DDD63_RS03625	COG0673	inositol 2-dehydrogenase activity
DDD63_RS03630	COG2188	Transcriptional regulator
DDD63_RS03635	COG0051	transcription antitermination factor activity, RNA binding
DDD63_RS03640	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DDD63_RS03645	COG0088	Forms part of the polypeptide exit tunnel
DDD63_RS03650	COG0089	rRNA binding
DDD63_RS03660	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DDD63_RS03665	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DDD63_RS03670	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DDD63_RS03675	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DDD63_RS03680	COG0255	Belongs to the universal ribosomal protein uL29 family
DDD63_RS03685	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DDD63_RS03695	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DDD63_RS03700	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DDD63_RS03705	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DDD63_RS03710	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DDD63_RS03715	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DDD63_RS03725	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DDD63_RS03730	COG1841	ribosomal large subunit assembly
DDD63_RS03735	COG0200	Binds to the 23S rRNA
DDD63_RS03740	COG0201	protein transport
DDD63_RS03745	COG0563	adenylate kinase activity
DDD63_RS03750	COG0024	Methionine aminopeptidase
DDD63_RS03755	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DDD63_RS03760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DDD63_RS03765	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DDD63_RS03770	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DDD63_RS03775	COG0202	RNA polymerase activity
DDD63_RS03780	COG0203	ribosomal protein L17
DDD63_RS03790	COG0101	tRNA pseudouridine synthase activity
DDD63_RS03800	COG0371	Dehydrogenase
DDD63_RS03805	COG1069	ribulokinase activity
DDD63_RS03810	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DDD63_RS03815	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DDD63_RS03840	COG1072	(Pantothenic acid kinase))
DDD63_RS03850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DDD63_RS03855	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DDD63_RS03860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DDD63_RS03865	COG0802	atpase or kinase
DDD63_RS03890	COG1053	succinate dehydrogenase
DDD63_RS03895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DDD63_RS03900	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DDD63_RS03910	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DDD63_RS03925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DDD63_RS04015	COG1309	transcriptional regulator
DDD63_RS04020	COG1131	(ABC) transporter
DDD63_RS04025	COG3559	Exporter of polyketide antibiotics
DDD63_RS04060	COG0657	acetylesterase activity
DDD63_RS04085	COG2271	Major facilitator Superfamily
DDD63_RS04105	COG0644	oxidoreductase
DDD63_RS04115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DDD63_RS04120	COG0857	belongs to the CobB CobQ family
DDD63_RS04120	COG0280	phosphate acetyltransferase
DDD63_RS04135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DDD63_RS04180	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DDD63_RS04195	COG4974	Belongs to the 'phage' integrase family
DDD63_RS04200	COG0596	Alpha beta hydrolase
DDD63_RS04275	COG1028	Short-chain dehydrogenase reductase Sdr
DDD63_RS04300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DDD63_RS04360	COG1131	(ABC) transporter
DDD63_RS04370	COG2197	response regulator
DDD63_RS04385	COG0138	bifunctional purine biosynthesis protein purh
DDD63_RS04395	COG1253	flavin adenine dinucleotide binding
DDD63_RS04405	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DDD63_RS04410	COG0205	6-phosphofructokinase activity
DDD63_RS04420	COG0166	Belongs to the GPI family
DDD63_RS04425	COG0039	L-malate dehydrogenase activity
DDD63_RS04440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DDD63_RS04455	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DDD63_RS04460	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DDD63_RS04470	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DDD63_RS04470	COG0662	Cupin 2, conserved barrel domain protein
DDD63_RS04475	COG1744	ABC transporter substrate-binding protein PnrA-like
DDD63_RS04485	COG4603	Belongs to the binding-protein-dependent transport system permease family
DDD63_RS04490	COG1079	Belongs to the binding-protein-dependent transport system permease family
DDD63_RS04505	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DDD63_RS04515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DDD63_RS04525	COG1611	Belongs to the LOG family
DDD63_RS04550	COG2239	Acts as a magnesium transporter
DDD63_RS04560	COG4607	ABC-type enterochelin transport system periplasmic component
DDD63_RS04570	COG4605	iron ion homeostasis
DDD63_RS04575	COG4604	ABC transporter, ATP-binding protein
DDD63_RS04585	COG2095	MarC family integral membrane protein
DDD63_RS04590	COG0513	Belongs to the DEAD box helicase family
DDD63_RS04600	COG1215	transferase activity, transferring glycosyl groups
DDD63_RS04610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DDD63_RS04675	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DDD63_RS04680	COG2884	Cell division ATP-binding protein ftsE
DDD63_RS04695	COG0739	heme binding
DDD63_RS04700	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DDD63_RS04710	COG0456	acetyltransferase
DDD63_RS04750	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DDD63_RS04760	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DDD63_RS04765	COG1234	tRNA 3'-trailer cleavage
DDD63_RS04775	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DDD63_RS04790	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
DDD63_RS04805	COG0318	PFAM AMP-dependent synthetase and ligase
DDD63_RS04810	COG0477	Major facilitator Superfamily
DDD63_RS04815	COG1960	acyl-CoA dehydrogenase activity
DDD63_RS04820	COG1309	transcriptional regulator
DDD63_RS04830	COG1131	(ABC) transporter
DDD63_RS04855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DDD63_RS04880	COG0395	ABC-type sugar transport system, permease component
DDD63_RS04885	COG1175	transmembrane transport
DDD63_RS04890	COG1653	transport
DDD63_RS04920	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DDD63_RS04925	COG0066	3-isopropylmalate dehydratase activity
DDD63_RS04945	COG1181	Belongs to the D-alanine--D-alanine ligase family
DDD63_RS04975	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DDD63_RS04985	COG0742	ribosomal rna small subunit methyltransferase
DDD63_RS04990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DDD63_RS05005	COG0571	ribonuclease III activity
DDD63_RS05010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DDD63_RS05025	COG1132	(ABC) transporter
DDD63_RS05030	COG4988	ABC transporter
DDD63_RS05035	COG1294	oxidase, subunit
DDD63_RS05040	COG1271	oxidase subunit
DDD63_RS05045	COG1530	ribonuclease E activity
DDD63_RS05050	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DDD63_RS05055	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DDD63_RS05065	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DDD63_RS05090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DDD63_RS05095	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DDD63_RS05100	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DDD63_RS05110	COG0799	negative regulation of ribosome biogenesis
DDD63_RS05115	COG0406	alpha-ribazole phosphatase activity
DDD63_RS05125	COG0205	6-phosphofructokinase activity
DDD63_RS05140	COG0583	DNA-binding transcription factor activity
DDD63_RS05160	COG2814	Major facilitator Superfamily
DDD63_RS05190	COG0488	(ABC) transporter
DDD63_RS05225	COG2197	response regulator
DDD63_RS05235	COG4585	Histidine kinase
DDD63_RS05240	COG1131	(ABC) transporter
DDD63_RS05255	COG3848	Pyruvate phosphate dikinase
DDD63_RS05255	COG0574	Belongs to the PEP-utilizing enzyme family
DDD63_RS05275	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DDD63_RS05275	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DDD63_RS05280	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DDD63_RS05295	COG1735	metal-dependent hydrolase with the TIM-barrel fold
DDD63_RS05320	COG2814	Major facilitator Superfamily
DDD63_RS05365	COG1464	Belongs to the NlpA lipoprotein family
DDD63_RS05370	COG2011	ABC-type metal ion transport system permease component
DDD63_RS05375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DDD63_RS05385	COG0813	purine-nucleoside phosphorylase activity
DDD63_RS05405	COG1120	ATPase activity
DDD63_RS05410	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDD63_RS05415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDD63_RS05440	COG1596	polysaccharide export
DDD63_RS05440	COG1555	photosystem II stabilization
DDD63_RS05455	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DDD63_RS05460	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DDD63_RS05470	COG0268	Binds directly to 16S ribosomal RNA
DDD63_RS05490	COG0481	GTPase activity
DDD63_RS05495	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DDD63_RS05515	COG1420	regulation of RNA biosynthetic process
DDD63_RS05520	COG0484	heat shock protein binding
DDD63_RS05535	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DDD63_RS05545	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DDD63_RS05565	COG2815	serine threonine protein kinase
DDD63_RS05565	COG0515	serine threonine protein kinase
DDD63_RS05575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DDD63_RS05580	COG1381	Involved in DNA repair and RecF pathway recombination
DDD63_RS05585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DDD63_RS05590	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DDD63_RS05610	COG0131	Imidazoleglycerol-phosphate dehydratase
DDD63_RS05620	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DDD63_RS05625	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DDD63_RS05635	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DDD63_RS05640	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DDD63_RS05660	COG0674	pyruvate-flavodoxin oxidoreductase activity
DDD63_RS05665	COG1013	pyruvate-flavodoxin oxidoreductase activity
DDD63_RS05670	COG0493	'glutamate synthase
DDD63_RS05680	COG1902	pentaerythritol trinitrate reductase activity
DDD63_RS05715	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DDD63_RS05760	COG1404	Belongs to the peptidase S8 family
DDD63_RS05770	COG0667	Aldo Keto reductase
DDD63_RS05775	COG1968	undecaprenyl-diphosphatase activity
DDD63_RS05780	COG0215	cysteine-tRNA ligase activity
DDD63_RS05785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DDD63_RS05790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DDD63_RS05805	COG2390	Transcriptional regulator
DDD63_RS05815	COG1063	alcohol dehydrogenase
DDD63_RS05825	COG1222	aaa ATPase
DDD63_RS05830	COG4122	O-methyltransferase activity
DDD63_RS05840	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DDD63_RS05855	COG0107	imidazoleglycerol-phosphate synthase activity
DDD63_RS05870	COG0134	indole-3-glycerol-phosphate synthase activity
DDD63_RS05875	COG0133	tryptophan synthase activity
DDD63_RS05905	COG2050	protein possibly involved in aromatic compounds catabolism
DDD63_RS05915	COG0539	negative regulation of cytoplasmic translation
DDD63_RS05920	COG1473	amidohydrolase
DDD63_RS05935	COG1464	Belongs to the NlpA lipoprotein family
DDD63_RS05945	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DDD63_RS05960	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DDD63_RS05975	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DDD63_RS05985	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DDD63_RS06005	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DDD63_RS06010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DDD63_RS06015	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DDD63_RS06020	COG0540	Belongs to the ATCase OTCase family
DDD63_RS06025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DDD63_RS06035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DDD63_RS06040	COG0284	orotidine-5'-phosphate decarboxylase activity
DDD63_RS06045	COG0194	GDP metabolic process
DDD63_RS06055	COG1758	RNA polymerase activity
DDD63_RS06065	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DDD63_RS06080	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DDD63_RS06085	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DDD63_RS06095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DDD63_RS06100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DDD63_RS06105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DDD63_RS06110	COG0140	phosphoribosyl-ATP diphosphatase activity
DDD63_RS06115	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DDD63_RS06145	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DDD63_RS06150	COG1216	Glycosyl transferase, family 2
DDD63_RS06175	COG0443	Heat shock 70 kDa protein
DDD63_RS06195	COG1716	ATPase activity
DDD63_RS06250	COG0587	DNA-directed DNA polymerase activity
DDD63_RS06260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DDD63_RS06275	COG0477	Major facilitator Superfamily
DDD63_RS06280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DDD63_RS06285	COG0800	Aldolase
DDD63_RS06290	COG1312	Catalyzes the dehydration of D-mannonate
DDD63_RS06295	COG0246	Mannitol dehydrogenase
DDD63_RS06305	COG1881	PFAM PEBP family protein
DDD63_RS06310	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DDD63_RS06335	COG1119	ATPase activity
DDD63_RS06370	COG0488	(ABC) transporter
DDD63_RS06380	COG2151	metal-sulfur cluster biosynthetic enzyme
DDD63_RS06395	COG0396	ATPase activity
DDD63_RS06405	COG0719	Fe-S assembly protein
DDD63_RS06430	COG0504	CTP synthase activity
DDD63_RS06435	COG0728	peptidoglycan biosynthetic process
DDD63_RS06455	COG0497	DNA recombination
DDD63_RS06460	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DDD63_RS06470	COG0647	UMP catabolic process
DDD63_RS06495	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DDD63_RS06505	COG2094	Belongs to the DNA glycosylase MPG family
DDD63_RS06510	COG0165	Argininosuccinate lyase
DDD63_RS06515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DDD63_RS06520	COG0778	Nitroreductase
DDD63_RS06525	COG0137	argininosuccinate synthase activity
DDD63_RS06535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DDD63_RS06540	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DDD63_RS06545	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DDD63_RS06550	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DDD63_RS06565	COG0124	histidyl-tRNA synthetase
DDD63_RS06575	COG1196	nuclear chromosome segregation
DDD63_RS06580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DDD63_RS06585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DDD63_RS06590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DDD63_RS06595	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DDD63_RS06605	COG2255	four-way junction helicase activity
DDD63_RS06610	COG0632	four-way junction helicase activity
DDD63_RS06615	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DDD63_RS06620	COG0217	transcriptional regulatory protein
DDD63_RS06640	COG0438	transferase activity, transferring glycosyl groups
DDD63_RS06645	COG1560	Kdo2-lipid A biosynthetic process
DDD63_RS06650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DDD63_RS06655	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DDD63_RS06705	COG1175	transmembrane transport
DDD63_RS06710	COG0395	ABC-type sugar transport system, permease component
DDD63_RS06720	COG1609	Transcriptional regulator
DDD63_RS06750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DDD63_RS06760	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DDD63_RS06765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DDD63_RS06780	COG0569	domain protein
DDD63_RS06815	COG1435	thymidine kinase activity
DDD63_RS06840	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DDD63_RS06845	COG0187	DNA topoisomerase II activity
DDD63_RS06855	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DDD63_RS06860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DDD63_RS06870	COG0142	geranyltranstransferase activity
DDD63_RS06880	COG3942	CHAP domain
DDD63_RS06880	COG1388	LysM domain
DDD63_RS06885	COG0515	serine threonine protein kinase
DDD63_RS06885	COG2815	serine threonine protein kinase
DDD63_RS06890	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DDD63_RS06940	COG3842	ATPase activity
DDD63_RS06950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DDD63_RS06960	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DDD63_RS06965	COG0545	Peptidyl-prolyl cis-trans isomerase
DDD63_RS06990	COG0167	dihydroorotate dehydrogenase activity
DDD63_RS07005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DDD63_RS07010	COG0508	dehydrogenase complex catalyzes the overall conversion of
DDD63_RS07025	COG0174	glutamine synthetase
DDD63_RS07030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DDD63_RS07045	COG0406	alpha-ribazole phosphatase activity
DDD63_RS07050	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DDD63_RS07055	COG0174	glutamine synthetase
DDD63_RS07065	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DDD63_RS07090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DDD63_RS07125	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DDD63_RS07150	COG0009	L-threonylcarbamoyladenylate synthase
DDD63_RS07220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DDD63_RS07260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DDD63_RS07265	COG0735	belongs to the Fur family
DDD63_RS07280	COG2153	protein acetylation
DDD63_RS07290	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DDD63_RS07305	COG1799	cell septum assembly
DDD63_RS07310	COG1496	oxidoreductase activity
DDD63_RS07325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DDD63_RS07330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DDD63_RS07335	COG0772	Belongs to the SEDS family
DDD63_RS07345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DDD63_RS07370	COG0275	rRNA processing
DDD63_RS07375	COG2001	Belongs to the MraZ family
DDD63_RS07385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DDD63_RS07405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DDD63_RS07455	COG0318	PFAM AMP-dependent synthetase and ligase
DDD63_RS07460	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DDD63_RS07470	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DDD63_RS07485	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DDD63_RS07490	COG2813	Specifically methylates the guanine in position
DDD63_RS07495	COG3739	integral membrane protein
DDD63_RS07505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DDD63_RS07510	COG2137	regulation of response to DNA damage stimulus
DDD63_RS07525	COG1396	sequence-specific DNA binding
DDD63_RS07530	COG1546	Belongs to the CinA family
DDD63_RS07530	COG1058	Belongs to the CinA family
DDD63_RS07555	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DDD63_RS07560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DDD63_RS07570	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DDD63_RS07575	COG0612	Peptidase, M16
DDD63_RS07580	COG1185	polyribonucleotide nucleotidyltransferase activity
DDD63_RS07600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DDD63_RS07605	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DDD63_RS07610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DDD63_RS07610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DDD63_RS07630	COG0779	Required for maturation of 30S ribosomal subunits
DDD63_RS07690	COG0442	prolyl-tRNA aminoacylation
DDD63_RS07705	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DDD63_RS07740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DDD63_RS07755	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DDD63_RS07765	COG0233	cytoplasmic translational termination
DDD63_RS07785	COG2818	Glycosylase
DDD63_RS07790	COG3830	Belongs to the UPF0237 family
DDD63_RS07795	COG2848	UPF0210 protein
DDD63_RS07815	COG0052	Belongs to the universal ribosomal protein uS2 family
DDD63_RS07825	COG4974	Belongs to the 'phage' integrase family
DDD63_RS07840	COG0792	nuclease activity
DDD63_RS07850	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DDD63_RS07855	COG0681	Belongs to the peptidase S26 family
DDD63_RS07860	COG0335	large ribosomal subunit rRNA binding
DDD63_RS07870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DDD63_RS07875	COG1837	Belongs to the UPF0109 family
DDD63_RS07880	COG0228	four-way junction DNA binding
DDD63_RS07885	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DDD63_RS07905	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DDD63_RS07940	COG1174	glycine betaine transport
DDD63_RS07950	COG0517	IMP dehydrogenase activity
DDD63_RS07950	COG1125	glycine betaine transport
DDD63_RS08010	COG1160	GTP binding
DDD63_RS08015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DDD63_RS08025	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DDD63_RS08050	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DDD63_RS08055	COG0149	triose-phosphate isomerase activity
DDD63_RS08060	COG0126	phosphoglycerate kinase activity
DDD63_RS08065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DDD63_RS08070	COG1481	regulation of sporulation
DDD63_RS08075	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DDD63_RS08105	COG0556	nucleotide-excision repair
DDD63_RS08110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DDD63_RS08115	COG0237	dephospho-CoA kinase activity
DDD63_RS08120	COG0656	L-ascorbic acid biosynthetic process
DDD63_RS08125	COG0698	ribose 5-phosphate isomerase
DDD63_RS08135	COG0730	response to heat
DDD63_RS08170	COG1461	Dihydroxyacetone kinase
DDD63_RS08175	COG2376	Dihydroxyacetone kinase
DDD63_RS08185	COG0285	dihydrofolate synthase activity
DDD63_RS08215	COG1022	Amp-dependent synthetase and ligase
DDD63_RS08220	COG0287	Prephenate dehydrogenase
DDD63_RS08220	COG1605	Chorismate mutase
DDD63_RS08225	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DDD63_RS08230	COG0740	serine-type endopeptidase activity
DDD63_RS08265	COG2885	chlorophyll binding
DDD63_RS08290	COG2409	Drug exporters of the RND superfamily
DDD63_RS08325	COG1739	Uncharacterized protein family UPF0029
DDD63_RS08335	COG1045	serine acetyltransferase
DDD63_RS08390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DDD63_RS08400	COG1946	Acyl-CoA thioesterase
DDD63_RS08405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DDD63_RS08415	COG1882	Formate acetyltransferase
DDD63_RS08425	COG1028	Short-chain dehydrogenase reductase Sdr
DDD63_RS08465	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DDD63_RS08480	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DDD63_RS08495	COG1136	(ABC) transporter
DDD63_RS08515	COG2814	Major facilitator Superfamily
DDD63_RS08520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DDD63_RS08525	COG2814	Major facilitator Superfamily
DDD63_RS08545	COG1764	response to oxidative stress
DDD63_RS08645	COG0577	efflux transmembrane transporter activity
DDD63_RS08645	COG1136	(ABC) transporter
DDD63_RS08650	COG1136	(ABC) transporter
DDD63_RS08650	COG0577	efflux transmembrane transporter activity
DDD63_RS08660	COG2197	response regulator
DDD63_RS08685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DDD63_RS08690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DDD63_RS08695	COG0473	3-isopropylmalate dehydrogenase activity
DDD63_RS08715	COG2949	membrane
DDD63_RS08720	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DDD63_RS08740	COG2985	domain, Protein
DDD63_RS08740	COG0569	domain protein
DDD63_RS08745	COG0129	dihydroxy-acid dehydratase activity
DDD63_RS08750	COG1132	(ABC) transporter
DDD63_RS08765	COG1120	ATPase activity
DDD63_RS08770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDD63_RS08810	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DDD63_RS08815	COG0154	amidase activity
DDD63_RS08820	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DDD63_RS08825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DDD63_RS08835	COG2135	peptidase activity
DDD63_RS08860	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DDD63_RS08865	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DDD63_RS08890	COG0114	fumarate hydratase activity
DDD63_RS08925	COG0326	Molecular chaperone. Has ATPase activity
DDD63_RS08940	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DDD63_RS08975	COG0741	lytic transglycosylase activity
DDD63_RS08975	COG0739	heme binding
DDD63_RS08975	COG1196	nuclear chromosome segregation
DDD63_RS09045	COG1615	UPF0182 protein
DDD63_RS09055	COG3480	Lon protease (S16) C-terminal proteolytic domain
DDD63_RS09080	COG0095	Lipoate-protein ligase
DDD63_RS09095	COG0180	Tryptophanyl-tRNA synthetase
DDD63_RS09115	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DDD63_RS09120	COG3833	ABC-type maltose transport systems, permease component
DDD63_RS09125	COG1175	transmembrane transport
DDD63_RS09175	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DDD63_RS09185	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DDD63_RS09190	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DDD63_RS09200	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DDD63_RS09205	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DDD63_RS09210	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DDD63_RS09215	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DDD63_RS09220	COG0356	it plays a direct role in the translocation of protons across the membrane
DDD63_RS09230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DDD63_RS09235	COG0009	L-threonylcarbamoyladenylate synthase
DDD63_RS09240	COG2890	protein-(glutamine-N5) methyltransferase activity
DDD63_RS09245	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DDD63_RS09260	COG0083	homoserine kinase activity
DDD63_RS09265	COG0460	homoserine dehydrogenase
DDD63_RS09280	COG0738	Major facilitator superfamily
DDD63_RS09295	COG0018	arginyl-trna synthetase
DDD63_RS09310	COG0741	lytic transglycosylase activity
DDD63_RS09310	COG1196	nuclear chromosome segregation
DDD63_RS09310	COG0739	heme binding
DDD63_RS09330	COG0577	efflux transmembrane transporter activity
DDD63_RS09330	COG1136	(ABC) transporter
DDD63_RS09355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DDD63_RS09370	COG0420	3'-5' exonuclease activity
DDD63_RS09375	COG0419	ATPase involved in DNA repair
DDD63_RS09380	COG0419	ATPase involved in DNA repair
DDD63_RS09385	COG0419	ATPase involved in DNA repair
DDD63_RS09425	COG0653	protein targeting
DDD63_RS09430	COG0737	Belongs to the 5'-nucleotidase family
DDD63_RS09440	COG1007	ATP synthesis coupled electron transport
DDD63_RS09450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DDD63_RS09455	COG0713	ATP synthesis coupled electron transport
DDD63_RS09470	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DDD63_RS09475	COG1034	ATP synthesis coupled electron transport
DDD63_RS09480	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DDD63_RS09490	COG0649	NAD binding
DDD63_RS09495	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDD63_RS09500	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDD63_RS09510	COG0644	oxidoreductase
DDD63_RS09515	COG2226	methyltransferase
DDD63_RS09550	COG1575	Belongs to the MenA family. Type 1 subfamily
DDD63_RS09580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DDD63_RS09590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DDD63_RS09600	COG1194	a g-specific adenine glycosylase
DDD63_RS09615	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DDD63_RS09625	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DDD63_RS09635	COG0247	lactate metabolic process
DDD63_RS09665	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DDD63_RS09670	COG1136	(ABC) transporter
DDD63_RS09670	COG0577	efflux transmembrane transporter activity
DDD63_RS09690	COG3550	peptidyl-serine autophosphorylation
DDD63_RS09700	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DDD63_RS09720	COG1070	Carbohydrate kinase
DDD63_RS09725	COG0647	UMP catabolic process
DDD63_RS09740	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DDD63_RS09745	COG1620	l-lactate permease
DDD63_RS09755	COG1139	Iron-sulfur cluster binding protein
DDD63_RS09760	COG1556	Lactate utilization protein
DDD63_RS09805	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DDD63_RS09810	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DDD63_RS09835	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DDD63_RS09840	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DDD63_RS09860	COG0037	tRNA processing
DDD63_RS09870	COG2027	D-alanyl-D-alanine carboxypeptidase
DDD63_RS09910	COG2873	o-acetylhomoserine
DDD63_RS09925	COG0247	lactate metabolic process
DDD63_RS09925	COG0277	FAD linked oxidase domain protein
DDD63_RS09945	COG1349	DNA-binding transcription factor activity
DDD63_RS09950	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DDD63_RS09955	COG3395	kinase activity
DDD63_RS09960	COG2610	gluconate transmembrane transporter activity
DDD63_RS09985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DDD63_RS09990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DDD63_RS10000	COG1129	ABC transporter
DDD63_RS10005	COG1172	Belongs to the binding-protein-dependent transport system permease family
DDD63_RS10010	COG1879	ABC-type sugar transport system periplasmic component
DDD63_RS10015	COG1082	Xylose isomerase domain protein TIM barrel
DDD63_RS10020	COG3959	Transketolase, thiamine diphosphate binding domain
DDD63_RS10040	COG4154	Belongs to the RbsD FucU family
DDD63_RS10060	COG2376	Dihydroxyacetone kinase
DDD63_RS10080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DDD63_RS10085	COG1414	Transcriptional regulator
DDD63_RS10105	COG1490	D-aminoacyl-tRNA deacylase activity
DDD63_RS10120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DDD63_RS10125	COG3485	protocatechuate 3,4-dioxygenase
DDD63_RS10140	COG0306	phosphate transporter
DDD63_RS10150	COG1051	belongs to the nudix hydrolase family
DDD63_RS10155	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DDD63_RS10175	COG0456	acetyltransferase
DDD63_RS10190	COG1902	pentaerythritol trinitrate reductase activity
DDD63_RS10190	COG0446	pyridine nucleotide-disulphide oxidoreductase
DDD63_RS10200	COG0783	Belongs to the Dps family
DDD63_RS10240	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DDD63_RS10265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DDD63_RS10300	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DDD63_RS10315	COG0737	Belongs to the 5'-nucleotidase family
DDD63_RS10320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DDD63_RS10330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DDD63_RS10335	COG0047	phosphoribosylformylglycinamidine synthase activity
DDD63_RS10345	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DDD63_RS10350	COG0151	Belongs to the GarS family
DDD63_RS10355	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DDD63_RS10380	COG0058	SHG alpha-glucan phosphorylase activity
DDD63_RS10415	COG0191	fructose-bisphosphate aldolase activity
DDD63_RS10435	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DDD63_RS10485	COG1122	ATPase activity
DDD63_RS10500	COG1960	acyl-CoA dehydrogenase activity
DDD63_RS10510	COG2223	nitrite transmembrane transporter activity
DDD63_RS10515	COG0318	PFAM AMP-dependent synthetase and ligase
DDD63_RS10540	COG1028	Short-chain dehydrogenase reductase Sdr
DDD63_RS10585	COG1674	ftsk spoiiie
DDD63_RS10605	COG1404	Belongs to the peptidase S8 family
DDD63_RS10610	COG1309	transcriptional regulator
DDD63_RS10695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DDD63_RS10710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DDD63_RS10715	COG3579	cysteine-type endopeptidase activity
DDD63_RS10795	COG1397	ADP-ribosylglycohydrolase
DDD63_RS10855	COG5002	protein histidine kinase activity
DDD63_RS10860	COG0745	RESPONSE REGULATOR receiver
DDD63_RS10870	COG0789	Transcriptional regulator
DDD63_RS10875	COG0484	heat shock protein binding
DDD63_RS10880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DDD63_RS10885	COG0443	Heat shock 70 kDa protein
DDD63_RS10910	COG1053	succinate dehydrogenase
DDD63_RS10910	COG3976	FMN-binding domain protein
DDD63_RS10910	COG3976	FMN-binding domain protein
DDD63_RS10910	COG1053	succinate dehydrogenase
DDD63_RS10920	COG1940	carbohydrate kinase activity
DDD63_RS10930	COG0477	Major facilitator Superfamily
DDD63_RS10970	COG1131	(ABC) transporter
DDD63_RS10980	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DDD63_RS10995	COG3842	ATPase activity
DDD63_RS11030	COG0582	viral genome integration into host DNA
DDD63_RS11050	COG3547	Transposase (IS116 IS110 IS902 family)
DDD63_RS11075	COG1136	(ABC) transporter
DDD63_RS11115	COG0714	Associated with various cellular activities
DDD63_RS11140	COG0789	Transcriptional regulator
DDD63_RS11150	COG1950	PFAM Membrane protein of
DDD63_RS11170	COG0586	Pfam SNARE associated Golgi protein
DDD63_RS11175	COG0577	efflux transmembrane transporter activity
DDD63_RS11175	COG1136	(ABC) transporter
DDD63_RS11215	COG1063	alcohol dehydrogenase
DDD63_RS11260	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DDD63_RS11265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DDD63_RS11270	COG0129	dihydroxy-acid dehydratase activity
DDD63_RS11275	COG2188	Transcriptional regulator
DDD63_RS11280	COG0246	Mannitol dehydrogenase
DDD63_RS11285	COG2610	gluconate transmembrane transporter activity
DDD63_RS11315	COG2197	response regulator
DDD63_RS11335	COG1115	amino acid carrier protein
DDD63_RS11340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DDD63_RS11365	COG2815	serine threonine protein kinase
DDD63_RS11365	COG0515	serine threonine protein kinase
DDD63_RS11405	COG0714	Associated with various cellular activities
DDD63_RS11440	COG0800	Aldolase
DDD63_RS11470	COG0343	queuine tRNA-ribosyltransferase activity
DDD63_RS11565	COG1355	regulation of microtubule-based process
DDD63_RS11570	COG0656	L-ascorbic acid biosynthetic process
DDD63_RS11580	COG0351	phosphomethylpyrimidine kinase
DDD63_RS11600	COG0305	Participates in initiation and elongation during chromosome replication
DDD63_RS11605	COG1953	Uracil, thiamine, allantoin
DDD63_RS11615	COG0252	asparaginase activity
DDD63_RS11620	COG3960	tartronate-semialdehyde synthase activity
DDD63_RS11630	COG3958	Transketolase
DDD63_RS11645	COG0540	Belongs to the ATCase OTCase family
DDD63_RS11650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DDD63_RS11655	COG1953	Uracil, thiamine, allantoin
DDD63_RS11670	COG1414	Transcriptional regulator
DDD63_RS11680	COG1609	Transcriptional regulator
DDD63_RS11685	COG2017	converts alpha-aldose to the beta-anomer
DDD63_RS11695	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DDD63_RS11710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DDD63_RS11720	COG2610	gluconate transmembrane transporter activity
DDD63_RS11725	COG2084	Dehydrogenase
DDD63_RS11735	COG2186	Transcriptional regulator
DDD63_RS11740	COG0359	binds to the 23S rRNA
DDD63_RS11745	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DDD63_RS11755	COG0360	Binds together with S18 to 16S ribosomal RNA
DDD63_RS11760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DDD63_RS11765	COG0628	permease
DDD63_RS11795	COG2801	Transposase and inactivated derivatives
DDD63_RS11830	COG0492	ferredoxin-NADP+ reductase activity
DDD63_RS11840	COG0492	ferredoxin-NADP+ reductase activity
DDD63_RS11865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DDD63_RS11885	COG0357	Ribosomal RNA small subunit methyltransferase G
DDD63_RS11900	COG0706	membrane insertase activity
DDD63_RS11905	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DDD63_RS11910	COG0594	ribonuclease P activity