locus-tag	class	description
HG15A2_RS00010	COG0592	DNA-directed DNA polymerase activity
HG15A2_RS00020	COG0187	DNA topoisomerase II activity
HG15A2_RS00040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG15A2_RS00055	COG0443	Heat shock 70 kDa protein
HG15A2_RS00090	COG2706	6-phosphogluconolactonase activity
HG15A2_RS00145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HG15A2_RS00150	COG0440	acetolactate synthase activity
HG15A2_RS00155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HG15A2_RS00170	COG0183	Belongs to the thiolase family
HG15A2_RS00205	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HG15A2_RS00215	COG1774	PSP1 C-terminal conserved region
HG15A2_RS00225	COG0563	adenylate kinase activity
HG15A2_RS00235	COG2366	antibiotic biosynthetic process
HG15A2_RS00240	COG0604	alcohol dehydrogenase
HG15A2_RS00245	COG2154	pterin-4-alpha-carbinolamine dehydratase
HG15A2_RS00250	COG2900	Belongs to the SlyX family
HG15A2_RS00265	COG1335	isochorismatase
HG15A2_RS00270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_RS00270	COG5549	protein import
HG15A2_RS00285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG15A2_RS00295	COG3485	protocatechuate 3,4-dioxygenase
HG15A2_RS00330	COG0493	'glutamate synthase
HG15A2_RS00340	COG0067	glutamate synthase
HG15A2_RS00340	COG0069	glutamate synthase activity
HG15A2_RS00340	COG0070	glutamate synthase
HG15A2_RS00345	COG0583	DNA-binding transcription factor activity
HG15A2_RS00350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG15A2_RS00355	COG0742	ribosomal rna small subunit methyltransferase
HG15A2_RS00360	COG0657	acetylesterase activity
HG15A2_RS00360	COG2755	lipolytic protein G-D-S-L family
HG15A2_RS00365	COG0488	(ABC) transporter
HG15A2_RS00370	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HG15A2_RS00375	COG1408	metallophosphoesterase
HG15A2_RS00420	COG1132	(ABC) transporter
HG15A2_RS00430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG15A2_RS00440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HG15A2_RS00445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HG15A2_RS00450	COG0515	serine threonine protein kinase
HG15A2_RS00465	COG3119	arylsulfatase activity
HG15A2_RS00475	COG4662	Binding-protein-dependent transport system inner membrane component
HG15A2_RS00485	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
HG15A2_RS00490	COG1229	Formylmethanofuran dehydrogenase subunit A
HG15A2_RS00500	COG0746	molybdenum cofactor guanylyltransferase activity
HG15A2_RS00510	COG0303	'Molybdopterin
HG15A2_RS00595	COG0463	Glycosyl transferase, family 2
HG15A2_RS00595	COG1216	Glycosyl transferase, family 2
HG15A2_RS00620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG15A2_RS00630	COG2208	phosphoserine phosphatase activity
HG15A2_RS00645	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HG15A2_RS00655	COG2193	ferroxidase activity
HG15A2_RS00660	COG0702	epimerase
HG15A2_RS00680	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_RS00690	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HG15A2_RS00700	COG3046	protein related to deoxyribodipyrimidine photolyase
HG15A2_RS00710	COG2208	phosphoserine phosphatase activity
HG15A2_RS00725	COG2204	response regulator
HG15A2_RS00745	COG2304	oxidoreductase activity
HG15A2_RS00750	COG2304	oxidoreductase activity
HG15A2_RS00765	COG0714	Associated with various cellular activities
HG15A2_RS00800	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS00855	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS00940	COG3206	protein involved in exopolysaccharide biosynthesis
HG15A2_RS00940	COG0489	protein tyrosine kinase activity
HG15A2_RS00960	COG1086	Polysaccharide biosynthesis protein
HG15A2_RS00975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HG15A2_RS00980	COG0438	transferase activity, transferring glycosyl groups
HG15A2_RS00985	COG0438	transferase activity, transferring glycosyl groups
HG15A2_RS01005	COG0438	transferase activity, transferring glycosyl groups
HG15A2_RS01010	COG0726	polysaccharide deacetylase
HG15A2_RS01035	COG0318	PFAM AMP-dependent synthetase and ligase
HG15A2_RS01045	COG0110	maltose O-acetyltransferase activity
HG15A2_RS01095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HG15A2_RS01100	COG0724	RNA recognition motif
HG15A2_RS01105	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG15A2_RS01120	COG0114	fumarate hydratase activity
HG15A2_RS01190	COG1733	regulation of RNA biosynthetic process
HG15A2_RS01195	COG1335	isochorismatase
HG15A2_RS01220	COG4974	Belongs to the 'phage' integrase family
HG15A2_RS01345	COG2815	serine threonine protein kinase
HG15A2_RS01345	COG0515	serine threonine protein kinase
HG15A2_RS01365	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HG15A2_RS01365	COG2146	nitrite reductase [NAD(P)H] activity
HG15A2_RS01370	COG0243	molybdopterin cofactor binding
HG15A2_RS01375	COG0437	4 iron, 4 sulfur cluster binding
HG15A2_RS01380	COG2223	nitrite transmembrane transporter activity
HG15A2_RS01390	COG1119	ATPase activity
HG15A2_RS01425	COG1196	nuclear chromosome segregation
HG15A2_RS01490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG15A2_RS01495	COG1136	(ABC) transporter
HG15A2_RS01585	COG2815	serine threonine protein kinase
HG15A2_RS01585	COG0515	serine threonine protein kinase
HG15A2_RS01715	COG3119	arylsulfatase activity
HG15A2_RS01735	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HG15A2_RS01770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HG15A2_RS01775	COG3608	succinylglutamate desuccinylase aspartoacylase
HG15A2_RS01775	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HG15A2_RS01815	COG1053	succinate dehydrogenase
HG15A2_RS01820	COG2009	succinate dehydrogenase
HG15A2_RS01830	COG5433	transposase activity
HG15A2_RS01855	COG0793	Belongs to the peptidase S41A family
HG15A2_RS01860	COG0138	bifunctional purine biosynthesis protein purh
HG15A2_RS01885	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HG15A2_RS01890	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG15A2_RS01890	COG1776	CheC inhibitor of MCP methylation
HG15A2_RS01940	COG0590	tRNA wobble adenosine to inosine editing
HG15A2_RS01945	COG1088	dTDP-glucose 4,6-dehydratase activity
HG15A2_RS01955	COG0515	serine threonine protein kinase
HG15A2_RS01955	COG2815	serine threonine protein kinase
HG15A2_RS01990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG15A2_RS02075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HG15A2_RS02095	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS02230	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HG15A2_RS02255	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HG15A2_RS02255	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HG15A2_RS02260	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HG15A2_RS02280	COG0714	Associated with various cellular activities
HG15A2_RS02340	COG5002	protein histidine kinase activity
HG15A2_RS02345	COG0745	RESPONSE REGULATOR receiver
HG15A2_RS02365	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HG15A2_RS02375	COG1070	Carbohydrate kinase
HG15A2_RS02380	COG3347	Dehydrogenase
HG15A2_RS02380	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_RS02385	COG1349	DNA-binding transcription factor activity
HG15A2_RS02405	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HG15A2_RS02410	COG0750	zinc metalloprotease
HG15A2_RS02415	COG0303	'Molybdopterin
HG15A2_RS02420	COG0512	Glutamine amidotransferase of anthranilate synthase
HG15A2_RS02425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HG15A2_RS02445	COG1695	Transcriptional regulator
HG15A2_RS02460	COG0071	Belongs to the small heat shock protein (HSP20) family
HG15A2_RS02465	COG0456	acetyltransferase
HG15A2_RS02480	COG0545	Peptidyl-prolyl cis-trans isomerase
HG15A2_RS02490	COG2165	general secretion pathway protein
HG15A2_RS02500	COG0175	sulfate reduction
HG15A2_RS02505	COG2895	sulfate adenylyltransferase (ATP) activity
HG15A2_RS02505	COG0529	Catalyzes the synthesis of activated sulfate
HG15A2_RS02525	COG1959	2 iron, 2 sulfur cluster binding
HG15A2_RS02530	COG0175	sulfate reduction
HG15A2_RS02540	COG2855	membrane
HG15A2_RS02560	COG1017	nitric oxide dioxygenase activity
HG15A2_RS02560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HG15A2_RS02570	COG1331	Highly conserved protein containing a thioredoxin domain
HG15A2_RS02580	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HG15A2_RS02590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HG15A2_RS02605	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HG15A2_RS02625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG15A2_RS02675	COG0587	DNA-directed DNA polymerase activity
HG15A2_RS02680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG15A2_RS02705	COG2318	DinB family
HG15A2_RS02735	COG2081	HI0933 family
HG15A2_RS02745	COG1230	cation diffusion facilitator family transporter
HG15A2_RS02775	COG0463	Glycosyl transferase, family 2
HG15A2_RS02800	COG1013	pyruvate-flavodoxin oxidoreductase activity
HG15A2_RS02805	COG0674	pyruvate-flavodoxin oxidoreductase activity
HG15A2_RS02805	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HG15A2_RS02825	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG15A2_RS02825	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG15A2_RS02835	COG2084	Dehydrogenase
HG15A2_RS02855	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HG15A2_RS02860	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HG15A2_RS02865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HG15A2_RS02870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HG15A2_RS02900	COG1205	dead DEAH box helicase
HG15A2_RS02900	COG1111	helicase
HG15A2_RS02925	COG0205	6-phosphofructokinase activity
HG15A2_RS02930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG15A2_RS02940	COG0513	Belongs to the DEAD box helicase family
HG15A2_RS02970	COG2755	lipolytic protein G-D-S-L family
HG15A2_RS02980	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG15A2_RS02980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG15A2_RS03000	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HG15A2_RS03005	COG1216	Glycosyl transferase, family 2
HG15A2_RS03035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG15A2_RS03040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HG15A2_RS03070	COG4956	integral membrane protein (PIN domain superfamily)
HG15A2_RS03075	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HG15A2_RS03100	COG0738	Major facilitator superfamily
HG15A2_RS03105	COG0110	maltose O-acetyltransferase activity
HG15A2_RS03110	COG0300	oxidoreductase activity
HG15A2_RS03125	COG1137	ATPase activity
HG15A2_RS03130	COG0681	Belongs to the peptidase S26 family
HG15A2_RS03135	COG0681	Belongs to the peptidase S26 family
HG15A2_RS03160	COG0481	GTPase activity
HG15A2_RS03165	COG1940	carbohydrate kinase activity
HG15A2_RS03170	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HG15A2_RS03175	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HG15A2_RS03190	COG2274	protein secretion by the type I secretion system
HG15A2_RS03205	COG1131	(ABC) transporter
HG15A2_RS03210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG15A2_RS03215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG15A2_RS03225	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HG15A2_RS03230	COG0459	protein refolding
HG15A2_RS03235	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HG15A2_RS03240	COG0539	negative regulation of cytoplasmic translation
HG15A2_RS03240	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HG15A2_RS03260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG15A2_RS03265	COG0799	negative regulation of ribosome biogenesis
HG15A2_RS03270	COG0018	arginyl-trna synthetase
HG15A2_RS03285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HG15A2_RS03290	COG1271	oxidase subunit
HG15A2_RS03310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HG15A2_RS03315	COG2088	sporulation resulting in formation of a cellular spore
HG15A2_RS03320	COG4864	UPF0365 protein
HG15A2_RS03325	COG4864	UPF0365 protein
HG15A2_RS03330	COG0482	sulfurtransferase activity
HG15A2_RS03335	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HG15A2_RS03360	COG0515	serine threonine protein kinase
HG15A2_RS03360	COG2815	serine threonine protein kinase
HG15A2_RS03375	COG0668	transmembrane transport
HG15A2_RS03385	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HG15A2_RS03390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HG15A2_RS03395	COG0406	alpha-ribazole phosphatase activity
HG15A2_RS03400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HG15A2_RS03425	COG0463	Glycosyl transferase, family 2
HG15A2_RS03440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HG15A2_RS03445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HG15A2_RS03450	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HG15A2_RS03460	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
HG15A2_RS03475	COG0515	serine threonine protein kinase
HG15A2_RS03475	COG2815	serine threonine protein kinase
HG15A2_RS03500	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HG15A2_RS03525	COG0686	Belongs to the AlaDH PNT family
HG15A2_RS03535	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HG15A2_RS03540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HG15A2_RS03560	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HG15A2_RS03580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG15A2_RS03590	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS03605	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS03620	COG1301	dicarboxylic acid transport
HG15A2_RS03635	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HG15A2_RS03650	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HG15A2_RS03680	COG0740	serine-type endopeptidase activity
HG15A2_RS03685	COG0740	serine-type endopeptidase activity
HG15A2_RS03690	COG0544	peptidyl-prolyl cis-trans isomerase activity
HG15A2_RS03725	COG0859	PFAM glycosyl transferase family 9
HG15A2_RS03730	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HG15A2_RS03735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HG15A2_RS03740	COG0297	glycogen (starch) synthase activity
HG15A2_RS03750	COG0438	transferase activity, transferring glycosyl groups
HG15A2_RS03765	COG4221	oxidoreductase activity
HG15A2_RS03785	COG0473	3-isopropylmalate dehydrogenase activity
HG15A2_RS03790	COG1022	Amp-dependent synthetase and ligase
HG15A2_RS03795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HG15A2_RS03825	COG0577	efflux transmembrane transporter activity
HG15A2_RS03825	COG1136	(ABC) transporter
HG15A2_RS03850	COG1136	(ABC) transporter
HG15A2_RS03920	COG2095	MarC family integral membrane protein
HG15A2_RS03930	COG3119	arylsulfatase activity
HG15A2_RS03970	COG0285	dihydrofolate synthase activity
HG15A2_RS03990	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HG15A2_RS04015	COG1397	ADP-ribosylglycohydrolase
HG15A2_RS04025	COG1671	Belongs to the UPF0178 family
HG15A2_RS04045	COG0432	Pfam Uncharacterised protein family UPF0047
HG15A2_RS04055	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG15A2_RS04085	COG0012	GTP binding
HG15A2_RS04095	COG1324	tolerance protein
HG15A2_RS04100	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HG15A2_RS04125	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HG15A2_RS04190	COG0438	transferase activity, transferring glycosyl groups
HG15A2_RS04210	COG1030	water channel activity
HG15A2_RS04215	COG1030	water channel activity
HG15A2_RS04220	COG0515	serine threonine protein kinase
HG15A2_RS04220	COG0457	Tetratricopeptide repeat
HG15A2_RS04230	COG4864	UPF0365 protein
HG15A2_RS04260	COG1785	Belongs to the alkaline phosphatase family
HG15A2_RS04270	COG1793	dna ligase
HG15A2_RS04270	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HG15A2_RS04290	COG0072	phenylalanine-tRNA ligase activity
HG15A2_RS04295	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HG15A2_RS04300	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HG15A2_RS04305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HG15A2_RS04310	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HG15A2_RS04315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HG15A2_RS04345	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG15A2_RS04375	COG1162	GTPase activity
HG15A2_RS04420	COG0515	serine threonine protein kinase
HG15A2_RS04420	COG2815	serine threonine protein kinase
HG15A2_RS04485	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG15A2_RS04530	COG3328	transposase activity
HG15A2_RS04545	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HG15A2_RS04615	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
HG15A2_RS04620	COG0189	ligase activity
HG15A2_RS04625	COG0318	PFAM AMP-dependent synthetase and ligase
HG15A2_RS04630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG15A2_RS04635	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HG15A2_RS04645	COG1858	cytochrome C peroxidase
HG15A2_RS04655	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HG15A2_RS04660	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HG15A2_RS04680	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HG15A2_RS04685	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HG15A2_RS04690	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HG15A2_RS04700	COG0596	Alpha beta hydrolase
HG15A2_RS04715	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG15A2_RS04730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG15A2_RS04740	COG1573	uracil-dna glycosylase
HG15A2_RS04745	COG1160	GTP binding
HG15A2_RS04765	COG0395	ABC-type sugar transport system, permease component
HG15A2_RS04775	COG1175	transmembrane transport
HG15A2_RS04795	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HG15A2_RS04800	COG0463	Glycosyl transferase, family 2
HG15A2_RS04865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG15A2_RS04870	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HG15A2_RS04890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HG15A2_RS04900	COG0140	phosphoribosyl-ATP diphosphatase activity
HG15A2_RS04905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HG15A2_RS04910	COG0142	geranyltranstransferase activity
HG15A2_RS04945	COG1278	Cold shock
HG15A2_RS04950	COG2197	response regulator
HG15A2_RS04960	COG1196	nuclear chromosome segregation
HG15A2_RS04985	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HG15A2_RS04990	COG0594	ribonuclease P activity
HG15A2_RS05015	COG3119	arylsulfatase activity
HG15A2_RS05070	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HG15A2_RS05085	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HG15A2_RS05090	COG0495	leucyl-tRNA aminoacylation
HG15A2_RS05100	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
HG15A2_RS05105	COG0527	aspartate kinase activity
HG15A2_RS05120	COG2268	Band 7 protein
HG15A2_RS05135	COG0525	valine-tRNA ligase activity
HG15A2_RS05140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG15A2_RS05155	COG1012	belongs to the aldehyde dehydrogenase family
HG15A2_RS05175	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HG15A2_RS05180	COG0357	Ribosomal RNA small subunit methyltransferase G
HG15A2_RS05205	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG15A2_RS05210	COG0514	ATP-dependent DNA helicase (RecQ)
HG15A2_RS05215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HG15A2_RS05215	COG0574	Belongs to the PEP-utilizing enzyme family
HG15A2_RS05250	COG0483	inositol monophosphate 1-phosphatase activity
HG15A2_RS05255	COG0052	Belongs to the universal ribosomal protein uS2 family
HG15A2_RS05260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HG15A2_RS05265	COG0528	UMP kinase activity
HG15A2_RS05270	COG0233	cytoplasmic translational termination
HG15A2_RS05290	COG0436	Aminotransferase
HG15A2_RS05295	COG1725	Transcriptional regulator
HG15A2_RS05300	COG1131	(ABC) transporter
HG15A2_RS05310	COG0505	Belongs to the CarA family
HG15A2_RS05320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HG15A2_RS05325	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HG15A2_RS05330	COG0575	Belongs to the CDS family
HG15A2_RS05335	COG1702	phosphate starvation-inducible protein PhoH
HG15A2_RS05345	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HG15A2_RS05360	COG0443	Heat shock 70 kDa protein
HG15A2_RS05370	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HG15A2_RS05395	COG1966	Carbon starvation protein
HG15A2_RS05410	COG0017	Asparaginyl-tRNA synthetase
HG15A2_RS05495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HG15A2_RS05500	COG4166	transmembrane transport
HG15A2_RS05505	COG0601	transmembrane transport
HG15A2_RS05510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HG15A2_RS05520	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HG15A2_RS05535	COG0616	signal peptide processing
HG15A2_RS05540	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HG15A2_RS05545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HG15A2_RS05555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HG15A2_RS05565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG15A2_RS05570	COG1477	protein flavinylation
HG15A2_RS05575	COG0586	Pfam SNARE associated Golgi protein
HG15A2_RS05605	COG0126	phosphoglycerate kinase activity
HG15A2_RS05620	COG0354	folic acid binding
HG15A2_RS05665	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HG15A2_RS05670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HG15A2_RS05695	COG0205	6-phosphofructokinase activity
HG15A2_RS05705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HG15A2_RS05710	COG1295	ribonuclease BN
HG15A2_RS05715	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_RS05735	COG2259	Doxx family
HG15A2_RS05745	COG0179	Fumarylacetoacetate (FAA) hydrolase
HG15A2_RS05750	COG0069	glutamate synthase activity
HG15A2_RS05760	COG0326	Molecular chaperone. Has ATPase activity
HG15A2_RS05785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG15A2_RS05795	COG0135	phosphoribosylanthranilate isomerase activity
HG15A2_RS05800	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HG15A2_RS05805	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HG15A2_RS05825	COG1192	Involved in chromosome partitioning
HG15A2_RS05830	COG1475	DNA binding
HG15A2_RS05845	COG3119	arylsulfatase activity
HG15A2_RS05850	COG0714	Associated with various cellular activities
HG15A2_RS05865	COG2304	oxidoreductase activity
HG15A2_RS05870	COG2304	oxidoreductase activity
HG15A2_RS05885	COG3119	arylsulfatase activity
HG15A2_RS05910	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HG15A2_RS05910	COG0426	domain, Protein
HG15A2_RS05925	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HG15A2_RS05930	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HG15A2_RS05940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_RS05945	COG3273	potassium ion transport
HG15A2_RS05945	COG0471	metal ion transport
HG15A2_RS05955	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HG15A2_RS05960	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HG15A2_RS05965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HG15A2_RS05970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HG15A2_RS05975	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HG15A2_RS05980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG15A2_RS05985	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HG15A2_RS05990	COG0193	aminoacyl-tRNA hydrolase activity
HG15A2_RS05995	COG0360	Binds together with S18 to 16S ribosomal RNA
HG15A2_RS06000	COG0629	single-stranded DNA binding
HG15A2_RS06005	COG0359	binds to the 23S rRNA
HG15A2_RS06010	COG0305	Participates in initiation and elongation during chromosome replication
HG15A2_RS06020	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HG15A2_RS06025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG15A2_RS06030	COG2183	response to ionizing radiation
HG15A2_RS06030	COG0539	negative regulation of cytoplasmic translation
HG15A2_RS06040	COG1943	Transposase
HG15A2_RS06050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HG15A2_RS06080	COG2363	Small membrane protein
HG15A2_RS06085	COG2379	hydroxypyruvate reductase
HG15A2_RS06125	COG0438	transferase activity, transferring glycosyl groups
HG15A2_RS06145	COG1215	transferase activity, transferring glycosyl groups
HG15A2_RS06160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HG15A2_RS06180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HG15A2_RS06190	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HG15A2_RS06195	COG1459	type II secretion system
HG15A2_RS06230	COG3118	belongs to the thioredoxin family
HG15A2_RS06250	COG4974	Belongs to the 'phage' integrase family
HG15A2_RS06265	COG2204	response regulator
HG15A2_RS06270	COG1620	l-lactate permease
HG15A2_RS06310	COG1968	undecaprenyl-diphosphatase activity
HG15A2_RS06335	COG0784	Response regulator, receiver
HG15A2_RS06340	COG4251	negative regulation of phosphorylation
HG15A2_RS06455	COG2204	response regulator
HG15A2_RS06465	COG3693	PFAM glycoside hydrolase, family 10
HG15A2_RS06470	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HG15A2_RS06470	COG3264	Mechanosensitive ion channel
HG15A2_RS06475	COG3119	arylsulfatase activity
HG15A2_RS06480	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HG15A2_RS06490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HG15A2_RS06500	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HG15A2_RS06505	COG1595	DNA-templated transcription, initiation
HG15A2_RS06525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG15A2_RS06530	COG0322	excinuclease ABC activity
HG15A2_RS06540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG15A2_RS06555	COG0504	CTP synthase activity
HG15A2_RS06560	COG0792	nuclease activity
HG15A2_RS06565	COG0335	large ribosomal subunit rRNA binding
HG15A2_RS06570	COG0336	Belongs to the RNA methyltransferase TrmD family
HG15A2_RS06590	COG2852	Protein conserved in bacteria
HG15A2_RS06600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HG15A2_RS06640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HG15A2_RS06645	COG4591	ABC-type transport system involved in lipoprotein release permease component
HG15A2_RS06650	COG1136	(ABC) transporter
HG15A2_RS06665	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HG15A2_RS06665	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HG15A2_RS06670	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HG15A2_RS06710	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HG15A2_RS06715	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HG15A2_RS06775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG15A2_RS06850	COG3119	arylsulfatase activity
HG15A2_RS06855	COG3119	arylsulfatase activity
HG15A2_RS06900	COG3119	arylsulfatase activity
HG15A2_RS07060	COG1070	Carbohydrate kinase
HG15A2_RS07070	COG0363	glucosamine-6-phosphate deaminase activity
HG15A2_RS07080	COG1349	DNA-binding transcription factor activity
HG15A2_RS07085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG15A2_RS07095	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HG15A2_RS07110	COG2188	Transcriptional regulator
HG15A2_RS07130	COG1136	(ABC) transporter
HG15A2_RS07135	COG0577	efflux transmembrane transporter activity
HG15A2_RS07135	COG1136	(ABC) transporter
HG15A2_RS07145	COG0640	Transcriptional regulator
HG15A2_RS07150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HG15A2_RS07155	COG0798	PFAM Bile acid sodium symporter
HG15A2_RS07180	COG1297	OPT oligopeptide transporter protein
HG15A2_RS07280	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HG15A2_RS07285	COG1757	Na H antiporter
HG15A2_RS07290	COG1619	proteins homologs of microcin C7 resistance protein MccF
HG15A2_RS07295	COG0405	Gamma-glutamyltransferase
HG15A2_RS07305	COG1686	Belongs to the peptidase S11 family
HG15A2_RS07310	COG4948	Mandelate Racemase Muconate Lactonizing
HG15A2_RS07345	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HG15A2_RS07350	COG2971	BadF BadG BcrA BcrD
HG15A2_RS07355	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HG15A2_RS07415	COG3250	beta-galactosidase activity
HG15A2_RS07415	COG5297	Belongs to the glycosyl hydrolase family 6
HG15A2_RS07430	COG1649	PFAM Uncharacterised BCR, COG1649
HG15A2_RS07435	COG2807	transmembrane transport
HG15A2_RS07445	COG1472	Belongs to the glycosyl hydrolase 3 family
HG15A2_RS07515	COG1172	Belongs to the binding-protein-dependent transport system permease family
HG15A2_RS07535	COG2205	protein histidine kinase activity
HG15A2_RS07550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG15A2_RS07560	COG1040	competence protein
HG15A2_RS07570	COG0181	hydroxymethylbilane synthase activity
HG15A2_RS07575	COG4786	Flagellar basal body rod
HG15A2_RS07580	COG4786	Flagellar basal body rod
HG15A2_RS07590	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HG15A2_RS07595	COG1706	bacterial-type flagellum-dependent cell motility
HG15A2_RS07610	COG4786	Flagellar basal body rod
HG15A2_RS07610	COG1256	bacterial-type flagellum assembly
HG15A2_RS07615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HG15A2_RS07620	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HG15A2_RS07625	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG15A2_RS07655	COG1473	amidohydrolase
HG15A2_RS07660	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HG15A2_RS07670	COG3118	belongs to the thioredoxin family
HG15A2_RS07695	COG3842	ATPase activity
HG15A2_RS07705	COG2165	general secretion pathway protein
HG15A2_RS07745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG15A2_RS07760	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS07770	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HG15A2_RS07775	COG0470	DNA polymerase III
HG15A2_RS07785	COG2205	protein histidine kinase activity
HG15A2_RS07790	COG0047	phosphoribosylformylglycinamidine synthase activity
HG15A2_RS07800	COG0287	Prephenate dehydrogenase
HG15A2_RS07835	COG1217	gtp-binding protein TYPA
HG15A2_RS07845	COG1408	metallophosphoesterase
HG15A2_RS07865	COG0714	Associated with various cellular activities
HG15A2_RS07885	COG0698	ribose 5-phosphate isomerase
HG15A2_RS07890	COG0515	serine threonine protein kinase
HG15A2_RS07890	COG2815	serine threonine protein kinase
HG15A2_RS07905	COG1131	(ABC) transporter
HG15A2_RS07920	COG0569	domain protein
HG15A2_RS07945	COG1074	ATP-dependent DNA helicase activity
HG15A2_RS07950	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HG15A2_RS07975	COG4401	Chorismate mutase type I
HG15A2_RS07990	COG1760	l-serine dehydratase
HG15A2_RS08005	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HG15A2_RS08010	COG0598	Magnesium transport protein CorA
HG15A2_RS08015	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HG15A2_RS08020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG15A2_RS08050	COG0515	serine threonine protein kinase
HG15A2_RS08050	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HG15A2_RS08065	COG2723	6-phospho-beta-galactosidase activity
HG15A2_RS08165	COG0515	serine threonine protein kinase
HG15A2_RS08165	COG2815	serine threonine protein kinase
HG15A2_RS08170	COG0538	isocitrate dehydrogenase activity
HG15A2_RS08190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG15A2_RS08195	COG5002	protein histidine kinase activity
HG15A2_RS08205	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HG15A2_RS08210	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG15A2_RS08215	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HG15A2_RS08230	COG1254	Belongs to the acylphosphatase family
HG15A2_RS08250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HG15A2_RS08260	COG1253	flavin adenine dinucleotide binding
HG15A2_RS08270	COG1070	Carbohydrate kinase
HG15A2_RS08275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG15A2_RS08280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HG15A2_RS08285	COG1233	COG1233 Phytoene dehydrogenase and related
HG15A2_RS08290	COG2304	oxidoreductase activity
HG15A2_RS08315	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HG15A2_RS08375	COG0811	peptide transport
HG15A2_RS08410	COG3119	arylsulfatase activity
HG15A2_RS08440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG15A2_RS08445	COG3119	arylsulfatase activity
HG15A2_RS08455	COG2814	Major facilitator Superfamily
HG15A2_RS08470	COG3119	arylsulfatase activity
HG15A2_RS08475	COG3119	arylsulfatase activity
HG15A2_RS08485	COG0800	Aldolase
HG15A2_RS08495	COG4948	Mandelate Racemase Muconate Lactonizing
HG15A2_RS08500	COG1802	Transcriptional regulator
HG15A2_RS08515	COG3119	arylsulfatase activity
HG15A2_RS08520	COG3119	arylsulfatase activity
HG15A2_RS08545	COG2815	serine threonine protein kinase
HG15A2_RS08545	COG0515	serine threonine protein kinase
HG15A2_RS08560	COG0134	indole-3-glycerol-phosphate synthase activity
HG15A2_RS08580	COG2204	response regulator
HG15A2_RS08595	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG15A2_RS08625	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HG15A2_RS08630	COG0515	serine threonine protein kinase
HG15A2_RS08630	COG2815	serine threonine protein kinase
HG15A2_RS08640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HG15A2_RS08650	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HG15A2_RS08655	COG0693	protein deglycase activity
HG15A2_RS08660	COG0824	Thioesterase
HG15A2_RS08685	COG0328	RNA-DNA hybrid ribonuclease activity
HG15A2_RS08690	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HG15A2_RS08700	COG1754	DNA topoisomerase type I activity
HG15A2_RS08700	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HG15A2_RS08710	COG0736	holo-[acyl-carrier-protein] synthase activity
HG15A2_RS08715	COG0180	Tryptophanyl-tRNA synthetase
HG15A2_RS08740	COG0727	PFAM Uncharacterised protein family (UPF0153)
HG15A2_RS08745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HG15A2_RS08750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HG15A2_RS08755	COG0314	molybdopterin synthase activity
HG15A2_RS08760	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HG15A2_RS08765	COG0277	FAD linked oxidase domain protein
HG15A2_RS08780	COG0302	gtp cyclohydrolase
HG15A2_RS08795	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HG15A2_RS08800	COG0717	Belongs to the dCTP deaminase family
HG15A2_RS08805	COG0475	glutathione-regulated potassium exporter activity
HG15A2_RS08805	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HG15A2_RS08815	COG0788	formyltetrahydrofolate deformylase activity
HG15A2_RS08825	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HG15A2_RS08825	COG0116	Belongs to the methyltransferase superfamily
HG15A2_RS08835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG15A2_RS08835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HG15A2_RS08840	COG1058	Belongs to the CinA family
HG15A2_RS08840	COG1546	Belongs to the CinA family
HG15A2_RS08855	COG0626	cystathionine gamma-synthase activity
HG15A2_RS08870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_RS08875	COG0358	DNA primase activity
HG15A2_RS08880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG15A2_RS08890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HG15A2_RS08950	COG4970	Tfp pilus assembly protein FimT
HG15A2_RS08965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HG15A2_RS08970	COG0590	tRNA wobble adenosine to inosine editing
HG15A2_RS08990	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HG15A2_RS09000	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HG15A2_RS09005	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HG15A2_RS09015	COG2342	PFAM TM1410 hypothetical-related protein
HG15A2_RS09050	COG0514	ATP-dependent DNA helicase (RecQ)
HG15A2_RS09055	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HG15A2_RS09065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HG15A2_RS09095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HG15A2_RS09100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HG15A2_RS09110	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HG15A2_RS09120	COG1459	type II secretion system
HG15A2_RS09130	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HG15A2_RS09145	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HG15A2_RS09150	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HG15A2_RS09175	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HG15A2_RS09190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HG15A2_RS09195	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HG15A2_RS09200	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS09250	COG1560	Kdo2-lipid A biosynthetic process
HG15A2_RS09260	COG1012	belongs to the aldehyde dehydrogenase family
HG15A2_RS09265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_RS09280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_RS09290	COG2766	serine protein kinase
HG15A2_RS09295	COG2718	Belongs to the UPF0229 family
HG15A2_RS09300	COG2719	SpoVR family
HG15A2_RS09315	COG3253	May function as heme-dependent peroxidase
HG15A2_RS09320	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HG15A2_RS09325	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HG15A2_RS09335	COG0295	cytidine deaminase activity
HG15A2_RS09360	COG1090	epimerase
HG15A2_RS09390	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS09395	COG0745	RESPONSE REGULATOR receiver
HG15A2_RS09470	COG1242	4 iron, 4 sulfur cluster binding
HG15A2_RS09480	COG1162	GTPase activity
HG15A2_RS09485	COG3264	Mechanosensitive ion channel
HG15A2_RS09485	COG1196	nuclear chromosome segregation
HG15A2_RS09490	COG1363	Peptidase, m42
HG15A2_RS09500	COG0084	hydrolase, TatD family'
HG15A2_RS09510	COG1007	ATP synthesis coupled electron transport
HG15A2_RS09520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HG15A2_RS09525	COG0713	ATP synthesis coupled electron transport
HG15A2_RS09530	COG0839	Belongs to the complex I subunit 6 family
HG15A2_RS09535	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HG15A2_RS09540	COG0649	NAD binding
HG15A2_RS09545	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG15A2_RS09550	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG15A2_RS09560	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG15A2_RS09570	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HG15A2_RS09580	COG0667	Aldo Keto reductase
HG15A2_RS09585	COG1131	(ABC) transporter
HG15A2_RS09595	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HG15A2_RS09630	COG0517	IMP dehydrogenase activity
HG15A2_RS09630	COG0617	tRNA 3'-terminal CCA addition
HG15A2_RS09630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HG15A2_RS09645	COG1960	acyl-CoA dehydrogenase activity
HG15A2_RS09650	COG0667	Aldo Keto reductase
HG15A2_RS09660	COG0113	porphobilinogen synthase activity
HG15A2_RS09665	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HG15A2_RS09690	COG3344	reverse transcriptase
HG15A2_RS09700	COG0204	Acyl-transferase
HG15A2_RS09700	COG0318	PFAM AMP-dependent synthetase and ligase
HG15A2_RS09725	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HG15A2_RS09730	COG0791	NLP P60 protein
HG15A2_RS09730	COG1388	LysM domain
HG15A2_RS09745	COG0515	serine threonine protein kinase
HG15A2_RS09745	COG2815	serine threonine protein kinase
HG15A2_RS09750	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HG15A2_RS09755	COG1214	PFAM Peptidase M22, glycoprotease
HG15A2_RS09765	COG0706	membrane insertase activity
HG15A2_RS09765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_RS09770	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG15A2_RS09790	COG3119	arylsulfatase activity
HG15A2_RS09790	COG3408	Glycogen debranching enzyme
HG15A2_RS09800	COG2815	serine threonine protein kinase
HG15A2_RS09800	COG0515	serine threonine protein kinase
HG15A2_RS09905	COG0437	4 iron, 4 sulfur cluster binding
HG15A2_RS09985	COG3119	arylsulfatase activity
HG15A2_RS09990	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG15A2_RS09995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG15A2_RS10030	COG3119	arylsulfatase activity
HG15A2_RS10035	COG3119	arylsulfatase activity
HG15A2_RS10050	COG3119	arylsulfatase activity
HG15A2_RS10065	COG4948	Mandelate Racemase Muconate Lactonizing
HG15A2_RS10070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG15A2_RS10080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG15A2_RS10085	COG2124	cytochrome p450
HG15A2_RS10095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG15A2_RS10125	COG5433	transposase activity
HG15A2_RS10150	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HG15A2_RS10160	COG0670	Belongs to the BI1 family
HG15A2_RS10200	COG1609	Transcriptional regulator
HG15A2_RS10200	COG2207	Transcriptional regulator
HG15A2_RS10205	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS10235	COG4372	Transposase
HG15A2_RS10250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG15A2_RS10300	COG4106	trans-aconitate 2-methyltransferase activity
HG15A2_RS10380	COG0542	response to heat
HG15A2_RS10400	COG0443	Heat shock 70 kDa protein
HG15A2_RS10415	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HG15A2_RS10420	COG0149	triose-phosphate isomerase activity
HG15A2_RS10430	COG1561	YicC-like family, N-terminal region
HG15A2_RS10435	COG0194	GDP metabolic process
HG15A2_RS10440	COG1758	RNA polymerase activity
HG15A2_RS10445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HG15A2_RS10450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HG15A2_RS10460	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HG15A2_RS10465	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HG15A2_RS10485	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HG15A2_RS10490	COG4232	protein-disulfide reductase activity
HG15A2_RS10515	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HG15A2_RS10525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HG15A2_RS10530	COG0484	heat shock protein binding
HG15A2_RS10535	COG0459	protein refolding
HG15A2_RS10540	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HG15A2_RS10545	COG0459	protein refolding
HG15A2_RS10555	COG2770	Histidine kinase
HG15A2_RS10555	COG3437	response regulator, receiver
HG15A2_RS10575	COG4717	serine-type aminopeptidase activity
HG15A2_RS10585	COG0463	Glycosyl transferase, family 2
HG15A2_RS10595	COG0564	pseudouridine synthase activity
HG15A2_RS10600	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_RS10605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HG15A2_RS10630	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HG15A2_RS10645	COG5002	protein histidine kinase activity
HG15A2_RS10655	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HG15A2_RS10660	COG1459	type II secretion system
HG15A2_RS10700	COG0606	chelatase, subunit chli
HG15A2_RS10720	COG0564	pseudouridine synthase activity
HG15A2_RS10725	COG1970	mechanosensitive ion channel activity
HG15A2_RS10730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HG15A2_RS10735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HG15A2_RS10740	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HG15A2_RS10755	COG2211	Major facilitator Superfamily
HG15A2_RS10765	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
HG15A2_RS10780	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HG15A2_RS10795	COG4565	transcriptional regulatory protein
HG15A2_RS10830	COG0275	rRNA processing
HG15A2_RS10840	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HG15A2_RS10850	COG0316	Belongs to the HesB IscA family
HG15A2_RS10855	COG1104	cysteine desulfurase activity
HG15A2_RS10860	COG4112	unkown
HG15A2_RS10865	COG2373	Large extracellular alpha-helical protein
HG15A2_RS10870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HG15A2_RS10875	COG3706	GGDEF domain
HG15A2_RS10880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HG15A2_RS10910	COG1216	Glycosyl transferase, family 2
HG15A2_RS10915	COG0297	glycogen (starch) synthase activity
HG15A2_RS10920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG15A2_RS10925	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HG15A2_RS10930	COG1216	Glycosyl transferase, family 2
HG15A2_RS10930	COG1442	glycosyl transferase family 8
HG15A2_RS10935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HG15A2_RS10940	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS10975	COG1477	protein flavinylation
HG15A2_RS10985	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HG15A2_RS10990	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HG15A2_RS11000	COG1805	sodium ion transport
HG15A2_RS11005	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HG15A2_RS11010	COG0045	succinate-CoA ligase (ADP-forming) activity
HG15A2_RS11015	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HG15A2_RS11055	COG0202	RNA polymerase activity
HG15A2_RS11065	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HG15A2_RS11065	COG1796	DNA polymerase
HG15A2_RS11080	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HG15A2_RS11125	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HG15A2_RS11125	COG1918	ferrous iron import across plasma membrane
HG15A2_RS11200	COG4245	von Willebrand factor, type A
HG15A2_RS11210	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
HG15A2_RS11230	COG5433	transposase activity
HG15A2_RS11235	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HG15A2_RS11240	COG0363	glucosamine-6-phosphate deaminase activity
HG15A2_RS11250	COG1233	COG1233 Phytoene dehydrogenase and related
HG15A2_RS11255	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG15A2_RS11265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG15A2_RS11295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG15A2_RS11375	COG2755	lipolytic protein G-D-S-L family
HG15A2_RS11395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG15A2_RS11415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG15A2_RS11425	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS11440	COG1914	H( )-stimulated, divalent metal cation uptake system
HG15A2_RS11445	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS11455	COG3328	transposase activity
HG15A2_RS11480	COG3119	arylsulfatase activity
HG15A2_RS11485	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS11530	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG15A2_RS11535	COG2942	2-epimerase
HG15A2_RS11565	COG1914	H( )-stimulated, divalent metal cation uptake system
HG15A2_RS11570	COG0363	glucosamine-6-phosphate deaminase activity
HG15A2_RS11575	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HG15A2_RS11625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HG15A2_RS11650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG15A2_RS11655	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HG15A2_RS11665	COG2239	Acts as a magnesium transporter
HG15A2_RS11670	COG0571	ribonuclease III activity
HG15A2_RS11680	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG15A2_RS11685	COG2208	phosphoserine phosphatase activity
HG15A2_RS11735	COG3119	arylsulfatase activity
HG15A2_RS11790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG15A2_RS11795	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HG15A2_RS11800	COG1609	Transcriptional regulator
HG15A2_RS11845	COG3119	arylsulfatase activity
HG15A2_RS11915	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HG15A2_RS11925	COG0714	Associated with various cellular activities
HG15A2_RS11940	COG1690	Belongs to the RtcB family
HG15A2_RS11950	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HG15A2_RS11960	COG1051	belongs to the nudix hydrolase family
HG15A2_RS11960	COG1056	cytidyltransferase-related domain
HG15A2_RS11965	COG1397	ADP-ribosylglycohydrolase
HG15A2_RS11975	COG1335	isochorismatase
HG15A2_RS11995	COG0494	nUDIX hydrolase
HG15A2_RS12005	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HG15A2_RS12015	COG3541	Predicted nucleotidyltransferase
HG15A2_RS12125	COG0430	RNA-3'-phosphate cyclase activity
HG15A2_RS12145	COG4650	regulator
HG15A2_RS12185	COG2132	Multicopper oxidase
HG15A2_RS12195	COG1937	Protein conserved in bacteria
HG15A2_RS12215	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HG15A2_RS12285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG15A2_RS12305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG15A2_RS12310	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HG15A2_RS12315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_RS12340	COG5433	transposase activity
HG15A2_RS12385	COG2207	Transcriptional regulator
HG15A2_RS12385	COG1609	Transcriptional regulator
HG15A2_RS12410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG15A2_RS12435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG15A2_RS12445	COG3328	transposase activity
HG15A2_RS12455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HG15A2_RS12475	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HG15A2_RS12520	COG2815	serine threonine protein kinase
HG15A2_RS12520	COG0515	serine threonine protein kinase
HG15A2_RS12595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG15A2_RS12605	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_RS12620	COG0517	IMP dehydrogenase activity
HG15A2_RS12620	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HG15A2_RS12620	COG0617	tRNA 3'-terminal CCA addition
HG15A2_RS12665	COG2165	general secretion pathway protein
HG15A2_RS12670	COG2204	response regulator
HG15A2_RS12675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HG15A2_RS12680	COG1459	type II secretion system
HG15A2_RS12690	COG2165	general secretion pathway protein
HG15A2_RS12755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HG15A2_RS12770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HG15A2_RS12800	COG1131	(ABC) transporter
HG15A2_RS12820	COG0612	Peptidase, M16
HG15A2_RS12825	COG0612	Peptidase, M16
HG15A2_RS12845	COG0803	Belongs to the bacterial solute-binding protein 9 family
HG15A2_RS12850	COG1121	(ABC) transporter
HG15A2_RS12855	COG1321	iron dependent repressor
HG15A2_RS12855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HG15A2_RS12860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HG15A2_RS12870	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HG15A2_RS12875	COG0105	UTP biosynthetic process
HG15A2_RS12890	COG1278	Cold shock
HG15A2_RS12925	COG2151	metal-sulfur cluster biosynthetic enzyme
HG15A2_RS12935	COG0719	Fe-S assembly protein
HG15A2_RS12945	COG0719	Fe-S assembly protein
HG15A2_RS12950	COG0396	ATPase activity
HG15A2_RS12955	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG15A2_RS12965	COG1115	amino acid carrier protein
HG15A2_RS12980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG15A2_RS12995	COG0515	serine threonine protein kinase
HG15A2_RS12995	COG2815	serine threonine protein kinase
HG15A2_RS13000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG15A2_RS13010	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS13015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_RS13020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_RS13065	COG0714	Associated with various cellular activities
HG15A2_RS13080	COG0776	regulation of translation
HG15A2_RS13090	COG0515	serine threonine protein kinase
HG15A2_RS13090	COG2815	serine threonine protein kinase
HG15A2_RS13140	COG2801	Transposase and inactivated derivatives
HG15A2_RS13205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HG15A2_RS13215	COG2204	response regulator
HG15A2_RS13225	COG0628	permease
HG15A2_RS13230	COG3237	CsbD-like
HG15A2_RS13265	COG3685	Protein conserved in bacteria
HG15A2_RS13270	COG3237	CsbD-like
HG15A2_RS13280	COG0628	permease
HG15A2_RS13295	COG0693	protein deglycase activity
HG15A2_RS13310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG15A2_RS13310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HG15A2_RS13330	COG4999	Histidine kinase
HG15A2_RS13330	COG3437	response regulator, receiver
HG15A2_RS13330	COG2205	protein histidine kinase activity
HG15A2_RS13330	COG3850	Histidine kinase
HG15A2_RS13345	COG4372	Transposase
HG15A2_RS13375	COG0811	peptide transport
HG15A2_RS13380	COG0848	biopolymer transport protein
HG15A2_RS13385	COG0848	biopolymer transport protein
HG15A2_RS13405	COG0515	serine threonine protein kinase
HG15A2_RS13405	COG2815	serine threonine protein kinase
HG15A2_RS13415	COG0564	pseudouridine synthase activity
HG15A2_RS13425	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS13435	COG1272	protein, Hemolysin III
HG15A2_RS13445	COG0402	S-adenosylhomocysteine deaminase activity
HG15A2_RS13450	COG1668	transmembrane transport
HG15A2_RS13455	COG4555	ABC transporter
HG15A2_RS13460	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HG15A2_RS13475	COG4152	abc transporter atp-binding protein
HG15A2_RS13495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HG15A2_RS13510	COG0243	molybdopterin cofactor binding
HG15A2_RS13515	COG0653	protein targeting
HG15A2_RS13535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG15A2_RS13575	COG0438	transferase activity, transferring glycosyl groups
HG15A2_RS13585	COG4589	Belongs to the CDS family
HG15A2_RS13610	COG0475	glutathione-regulated potassium exporter activity
HG15A2_RS13610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HG15A2_RS13620	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HG15A2_RS13630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HG15A2_RS13650	COG4191	Histidine kinase
HG15A2_RS13655	COG2204	response regulator
HG15A2_RS13665	COG0247	lactate metabolic process
HG15A2_RS13670	COG0277	FAD linked oxidase domain protein
HG15A2_RS13675	COG0277	FAD linked oxidase domain protein
HG15A2_RS13690	COG3344	reverse transcriptase
HG15A2_RS13775	COG5433	transposase activity
HG15A2_RS13795	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG15A2_RS13805	COG3237	CsbD-like
HG15A2_RS13810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HG15A2_RS13825	COG0438	transferase activity, transferring glycosyl groups
HG15A2_RS13850	COG5433	transposase activity
HG15A2_RS13910	COG0515	serine threonine protein kinase
HG15A2_RS13910	COG2815	serine threonine protein kinase
HG15A2_RS13925	COG0714	Associated with various cellular activities
HG15A2_RS13965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG15A2_RS13970	COG0537	adenosine 5'-monophosphoramidase activity
HG15A2_RS14030	COG3119	arylsulfatase activity
HG15A2_RS14035	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HG15A2_RS14055	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HG15A2_RS14070	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HG15A2_RS14135	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HG15A2_RS14135	COG1333	cytochrome c biogenesis protein
HG15A2_RS14160	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HG15A2_RS14165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HG15A2_RS14170	COG0154	amidase activity
HG15A2_RS14175	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HG15A2_RS14185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HG15A2_RS14205	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HG15A2_RS14215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HG15A2_RS14220	COG0552	protein localization to endoplasmic reticulum
HG15A2_RS14225	COG0004	ammonium transporteR
HG15A2_RS14240	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HG15A2_RS14245	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HG15A2_RS14250	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HG15A2_RS14255	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HG15A2_RS14260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HG15A2_RS14265	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HG15A2_RS14275	COG0356	it plays a direct role in the translocation of protons across the membrane
HG15A2_RS14295	COG1606	tRNA processing
HG15A2_RS14350	COG2755	lipolytic protein G-D-S-L family
HG15A2_RS14360	COG0515	serine threonine protein kinase
HG15A2_RS14370	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HG15A2_RS14395	COG2203	Gaf domain
HG15A2_RS14395	COG5001	Diguanylate cyclase
HG15A2_RS14395	COG4251	negative regulation of phosphorylation
HG15A2_RS14395	COG3706	GGDEF domain
HG15A2_RS14415	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HG15A2_RS14425	COG3706	GGDEF domain
HG15A2_RS14430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG15A2_RS14445	COG0473	3-isopropylmalate dehydrogenase activity
HG15A2_RS14460	COG2326	polyphosphate kinase activity
HG15A2_RS14465	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HG15A2_RS14480	COG1678	Uncharacterized ACR, COG1678
HG15A2_RS14495	COG1904	glucuronate isomerase
HG15A2_RS14525	COG0534	Mate efflux family protein
HG15A2_RS14540	COG0556	nucleotide-excision repair
HG15A2_RS14565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HG15A2_RS14570	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HG15A2_RS14590	COG0471	metal ion transport
HG15A2_RS14635	COG1609	Transcriptional regulator
HG15A2_RS14670	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HG15A2_RS14720	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HG15A2_RS14740	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HG15A2_RS14760	COG0066	3-isopropylmalate dehydratase activity
HG15A2_RS14765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HG15A2_RS14770	COG0515	serine threonine protein kinase
HG15A2_RS14770	COG2815	serine threonine protein kinase
HG15A2_RS14780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG15A2_RS14785	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HG15A2_RS14790	COG0393	Putative heavy-metal-binding
HG15A2_RS14795	COG0393	Putative heavy-metal-binding
HG15A2_RS14810	COG1404	Belongs to the peptidase S8 family
HG15A2_RS14815	COG3958	Transketolase
HG15A2_RS14820	COG3959	Transketolase, thiamine diphosphate binding domain
HG15A2_RS14825	COG0667	Aldo Keto reductase
HG15A2_RS14830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HG15A2_RS14880	COG0489	protein tyrosine kinase activity
HG15A2_RS14880	COG3206	protein involved in exopolysaccharide biosynthesis
HG15A2_RS14890	COG1086	Polysaccharide biosynthesis protein
HG15A2_RS14900	COG0477	Major facilitator Superfamily
HG15A2_RS14900	COG2814	Major facilitator Superfamily
HG15A2_RS14925	COG4464	protein tyrosine phosphatase activity
HG15A2_RS14930	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG15A2_RS14940	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG15A2_RS14950	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG15A2_RS14980	COG2197	response regulator
HG15A2_RS14985	COG0464	growth
HG15A2_RS15000	COG5487	UPF0391 membrane protein
HG15A2_RS15015	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HG15A2_RS15035	COG0515	serine threonine protein kinase
HG15A2_RS15035	COG0457	Tetratricopeptide repeat
HG15A2_RS15050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HG15A2_RS15060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HG15A2_RS15065	COG2010	Cytochrome c
HG15A2_RS15070	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HG15A2_RS15090	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HG15A2_RS15095	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HG15A2_RS15105	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HG15A2_RS15130	COG0006	proline dipeptidase activity
HG15A2_RS15135	COG0511	ligase activity, forming carbon-carbon bonds
HG15A2_RS15140	COG0439	Biotin carboxylase
HG15A2_RS15145	COG0205	6-phosphofructokinase activity
HG15A2_RS15150	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HG15A2_RS15155	COG0131	Imidazoleglycerol-phosphate dehydratase
HG15A2_RS15165	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HG15A2_RS15170	COG0307	riboflavin synthase, alpha
HG15A2_RS15180	COG0688	phosphatidylethanolamine metabolic process
HG15A2_RS15185	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HG15A2_RS15190	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_RS15195	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HG15A2_RS15210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HG15A2_RS15260	COG1132	(ABC) transporter
HG15A2_RS15265	COG3119	arylsulfatase activity
HG15A2_RS15310	COG2211	Major facilitator Superfamily
HG15A2_RS15330	COG0577	efflux transmembrane transporter activity
HG15A2_RS15330	COG1136	(ABC) transporter
HG15A2_RS15345	COG4191	Histidine kinase
HG15A2_RS15355	COG0577	efflux transmembrane transporter activity
HG15A2_RS15355	COG1136	(ABC) transporter
HG15A2_RS15365	COG0247	lactate metabolic process
HG15A2_RS15365	COG0277	FAD linked oxidase domain protein
HG15A2_RS15385	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_RS15400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HG15A2_RS15415	COG0811	peptide transport
HG15A2_RS15470	COG5433	transposase activity
HG15A2_RS15560	COG1609	Transcriptional regulator
HG15A2_RS15560	COG2207	Transcriptional regulator
HG15A2_RS15595	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS15640	COG2801	Transposase and inactivated derivatives
HG15A2_RS15675	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HG15A2_RS15690	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HG15A2_RS15695	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HG15A2_RS15700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HG15A2_RS15715	COG2244	polysaccharide biosynthetic process
HG15A2_RS15740	COG1216	Glycosyl transferase, family 2
HG15A2_RS15750	COG0493	'glutamate synthase
HG15A2_RS15755	COG0535	radical SAM domain protein
HG15A2_RS15760	COG1505	serine-type exopeptidase activity
HG15A2_RS15765	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HG15A2_RS15785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HG15A2_RS15790	COG1078	dGTPase activity
HG15A2_RS15840	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HG15A2_RS15860	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HG15A2_RS15865	COG0254	rRNA binding
HG15A2_RS15870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HG15A2_RS15875	COG2890	protein-(glutamine-N5) methyltransferase activity
HG15A2_RS15895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG15A2_RS15910	COG4974	Belongs to the 'phage' integrase family
HG15A2_RS15925	COG0811	peptide transport
HG15A2_RS15955	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG15A2_RS15960	COG1684	flagellar biosynthetic protein fliR
HG15A2_RS15965	COG1987	bacterial-type flagellum assembly
HG15A2_RS15970	COG1338	Plays a role in the flagellum-specific transport system
HG15A2_RS15995	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HG15A2_RS16000	COG1582	Flagellar protein (FlbD)
HG15A2_RS16010	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HG15A2_RS16030	COG1157	protein secretion by the type III secretion system
HG15A2_RS16040	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG15A2_RS16050	COG1677	Flagellar hook-basal body complex protein FliE
HG15A2_RS16060	COG1815	bacterial-type flagellum-dependent cell motility
HG15A2_RS16070	COG3852	Histidine kinase
HG15A2_RS16090	COG0039	L-malate dehydrogenase activity
HG15A2_RS16100	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG15A2_RS16105	COG1419	protein localization to endoplasmic reticulum
HG15A2_RS16120	COG1191	sigma factor activity
HG15A2_RS16140	COG0137	argininosuccinate synthase activity
HG15A2_RS16155	COG0540	Belongs to the ATCase OTCase family
HG15A2_RS16170	COG0745	RESPONSE REGULATOR receiver
HG15A2_RS16175	COG0445	tRNA wobble uridine modification
HG15A2_RS16195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HG15A2_RS16200	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HG15A2_RS16215	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HG15A2_RS16230	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HG15A2_RS16240	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS16250	COG0658	competence protein
HG15A2_RS16250	COG2333	competence protein COMEC
HG15A2_RS16260	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HG15A2_RS16265	COG1185	polyribonucleotide nucleotidyltransferase activity
HG15A2_RS16270	COG4191	Histidine kinase
HG15A2_RS16285	COG0640	Transcriptional regulator
HG15A2_RS16300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HG15A2_RS16305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HG15A2_RS16310	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HG15A2_RS16325	COG2885	chlorophyll binding
HG15A2_RS16330	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HG15A2_RS16335	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HG15A2_RS16370	COG1674	ftsk spoiiie
HG15A2_RS16375	COG0488	(ABC) transporter
HG15A2_RS16380	COG2226	methyltransferase
HG15A2_RS16385	COG0148	phosphopyruvate hydratase activity
HG15A2_RS16425	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HG15A2_RS16430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HG15A2_RS16430	COG0519	Catalyzes the synthesis of GMP from XMP
HG15A2_RS16440	COG0488	(ABC) transporter
HG15A2_RS16460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HG15A2_RS16475	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HG15A2_RS16500	COG0321	lipoyl(octanoyl) transferase activity
HG15A2_RS16500	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HG15A2_RS16505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HG15A2_RS16535	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HG15A2_RS16540	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HG15A2_RS16545	COG0602	queuosine metabolic process
HG15A2_RS16575	COG0151	Belongs to the GarS family
HG15A2_RS16585	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HG15A2_RS16620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HG15A2_RS16630	COG0109	protoheme IX farnesyltransferase activity
HG15A2_RS16635	COG1845	cytochrome c oxidase, subunit III
HG15A2_RS16635	COG1845	cytochrome c oxidase, subunit III
HG15A2_RS16645	COG1131	(ABC) transporter
HG15A2_RS16660	COG2322	membrane
HG15A2_RS16690	COG1519	Transferase
HG15A2_RS16705	COG1131	(ABC) transporter
HG15A2_RS16725	COG1045	serine acetyltransferase
HG15A2_RS16735	COG0805	protein transport
HG15A2_RS16740	COG1482	cell wall glycoprotein biosynthetic process
HG15A2_RS16750	COG1187	pseudouridine synthase activity
HG15A2_RS16755	COG0543	2 iron, 2 sulfur cluster binding
HG15A2_RS16760	COG0268	Binds directly to 16S ribosomal RNA
HG15A2_RS16785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_RS16790	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HG15A2_RS16825	COG0736	holo-[acyl-carrier-protein] synthase activity
HG15A2_RS16835	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HG15A2_RS16840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HG15A2_RS16875	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HG15A2_RS16915	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG15A2_RS16930	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HG15A2_RS16935	COG0589	response to stress
HG15A2_RS16945	COG3002	Belongs to the UPF0753 family
HG15A2_RS16950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HG15A2_RS16955	COG1007	ATP synthesis coupled electron transport
HG15A2_RS16965	COG0288	reversible hydration of carbon dioxide
HG15A2_RS16970	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HG15A2_RS16980	COG0589	response to stress
HG15A2_RS16995	COG0589	response to stress
HG15A2_RS17010	COG4191	Histidine kinase
HG15A2_RS17015	COG2201	protein-glutamate methylesterase activity
HG15A2_RS17035	COG2204	response regulator
HG15A2_RS17060	COG0730	response to heat
HG15A2_RS17065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG15A2_RS17070	COG0446	pyridine nucleotide-disulphide oxidoreductase
HG15A2_RS17080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG15A2_RS17090	COG1136	(ABC) transporter
HG15A2_RS17110	COG1305	Transglutaminase-like
HG15A2_RS17115	COG2308	Evidence 4 Homologs of previously reported genes of
HG15A2_RS17130	COG2308	Evidence 4 Homologs of previously reported genes of
HG15A2_RS17135	COG1253	flavin adenine dinucleotide binding
HG15A2_RS17150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG15A2_RS17155	COG0398	Pfam SNARE associated Golgi protein
HG15A2_RS17160	COG3842	ATPase activity
HG15A2_RS17170	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HG15A2_RS17195	COG0124	histidyl-tRNA synthetase
HG15A2_RS17210	COG0189	ligase activity
HG15A2_RS17210	COG4067	protein conserved in archaea
HG15A2_RS17215	COG0800	Aldolase
HG15A2_RS17220	COG0284	orotidine-5'-phosphate decarboxylase activity
HG15A2_RS17260	COG0667	Aldo Keto reductase
HG15A2_RS17275	COG1131	(ABC) transporter
HG15A2_RS17290	COG0159	tryptophan synthase activity
HG15A2_RS17295	COG0133	tryptophan synthase activity
HG15A2_RS17300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HG15A2_RS17305	COG0457	Tetratricopeptide repeat
HG15A2_RS17305	COG0515	serine threonine protein kinase
HG15A2_RS17310	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HG15A2_RS17315	COG0347	Belongs to the P(II) protein family
HG15A2_RS17320	COG0004	ammonium transporteR
HG15A2_RS17325	COG2096	Adenosyltransferase
HG15A2_RS17330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG15A2_RS17375	COG4191	Histidine kinase
HG15A2_RS17385	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HG15A2_RS17390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HG15A2_RS17395	COG0784	Response regulator, receiver
HG15A2_RS17395	COG2205	protein histidine kinase activity
HG15A2_RS17400	COG0328	RNA-DNA hybrid ribonuclease activity
HG15A2_RS17405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HG15A2_RS17415	COG0515	serine threonine protein kinase
HG15A2_RS17415	COG2815	serine threonine protein kinase
HG15A2_RS17420	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HG15A2_RS17425	COG1201	RNA secondary structure unwinding
HG15A2_RS17430	COG0415	Belongs to the DNA photolyase family
HG15A2_RS17445	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HG15A2_RS17460	COG1136	(ABC) transporter
HG15A2_RS17460	COG0577	efflux transmembrane transporter activity
HG15A2_RS17465	COG1136	(ABC) transporter
HG15A2_RS17485	COG3386	PFAM SMP-30 Gluconolaconase
HG15A2_RS17505	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HG15A2_RS17530	COG2188	Transcriptional regulator
HG15A2_RS17590	COG2207	Transcriptional regulator
HG15A2_RS17590	COG1609	Transcriptional regulator
HG15A2_RS17615	COG0658	competence protein
HG15A2_RS17615	COG2333	competence protein COMEC
HG15A2_RS17635	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HG15A2_RS17635	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HG15A2_RS17650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HG15A2_RS17655	COG0363	glucosamine-6-phosphate deaminase activity
HG15A2_RS17665	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS17670	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG15A2_RS17740	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HG15A2_RS17755	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS17775	COG1914	H( )-stimulated, divalent metal cation uptake system
HG15A2_RS17865	COG2115	Belongs to the xylose isomerase family
HG15A2_RS17870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG15A2_RS17875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG15A2_RS17895	COG0704	Plays a role in the regulation of phosphate uptake
HG15A2_RS17900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HG15A2_RS17905	COG0581	inorganic phosphate transmembrane transporter activity
HG15A2_RS17910	COG0573	inorganic phosphate transmembrane transporter activity
HG15A2_RS17915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HG15A2_RS17920	COG5002	protein histidine kinase activity
HG15A2_RS18020	COG0217	transcriptional regulatory protein
HG15A2_RS18030	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HG15A2_RS18035	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HG15A2_RS18040	COG2251	uridine kinase activity
HG15A2_RS18040	COG0195	Participates in both transcription termination and antitermination
HG15A2_RS18045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG15A2_RS18060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG15A2_RS18065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HG15A2_RS18070	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_RS18075	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HG15A2_RS18080	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HG15A2_RS18090	COG2255	four-way junction helicase activity
HG15A2_RS18105	COG0509	glycine decarboxylation via glycine cleavage system
HG15A2_RS18115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG15A2_RS18125	COG1454	alcohol dehydrogenase
HG15A2_RS18150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG15A2_RS18180	COG4536	flavin adenine dinucleotide binding
HG15A2_RS18205	COG0530	calcium, potassium:sodium antiporter activity
HG15A2_RS18215	COG0469	pyruvate kinase activity
HG15A2_RS18220	COG2382	esterase
HG15A2_RS18220	COG3693	PFAM glycoside hydrolase, family 10
HG15A2_RS18230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HG15A2_RS18235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HG15A2_RS18240	COG0142	geranyltranstransferase activity
HG15A2_RS18245	COG1722	exodeoxyribonuclease VII activity
HG15A2_RS18250	COG1570	exodeoxyribonuclease VII activity
HG15A2_RS18275	COG0037	tRNA processing
HG15A2_RS18280	COG1418	mRNA catabolic process
HG15A2_RS18285	COG1692	metallophosphoesterase
HG15A2_RS18315	COG1054	Belongs to the UPF0176 family
HG15A2_RS18320	COG0248	Ppx GppA phosphatase
HG15A2_RS18325	COG0196	riboflavin kinase activity
HG15A2_RS18330	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HG15A2_RS18340	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HG15A2_RS18345	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HG15A2_RS18370	COG0516	GMP reductase activity
HG15A2_RS18370	COG0517	IMP dehydrogenase activity
HG15A2_RS18380	COG3132	Protein of unknown function, DUF480
HG15A2_RS18395	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HG15A2_RS18400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_RS18405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG15A2_RS18415	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HG15A2_RS18425	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_RS18440	COG0825	malonyl-CoA metabolic process
HG15A2_RS18445	COG0515	serine threonine protein kinase
HG15A2_RS18445	COG2815	serine threonine protein kinase
HG15A2_RS18450	COG0668	transmembrane transport
HG15A2_RS18460	COG0101	tRNA pseudouridine synthase activity
HG15A2_RS18465	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HG15A2_RS18475	COG1490	D-aminoacyl-tRNA deacylase activity
HG15A2_RS18485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG15A2_RS18515	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HG15A2_RS18525	COG0406	alpha-ribazole phosphatase activity
HG15A2_RS18560	COG0436	Aminotransferase
HG15A2_RS18580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HG15A2_RS18625	COG0343	queuine tRNA-ribosyltransferase activity
HG15A2_RS18635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HG15A2_RS18720	COG3119	arylsulfatase activity
HG15A2_RS18730	COG3119	arylsulfatase activity
HG15A2_RS18730	COG3408	Glycogen debranching enzyme
HG15A2_RS18735	COG0702	epimerase
HG15A2_RS18760	COG0481	GTPase activity
HG15A2_RS18775	COG0697	spore germination
HG15A2_RS18855	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HG15A2_RS18865	COG1017	nitric oxide dioxygenase activity
HG15A2_RS18865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HG15A2_RS18880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HG15A2_RS18885	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HG15A2_RS18920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HG15A2_RS18925	COG5002	protein histidine kinase activity
HG15A2_RS18930	COG0745	RESPONSE REGULATOR receiver
HG15A2_RS18940	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HG15A2_RS18960	COG0259	pyridoxamine-phosphate oxidase activity
HG15A2_RS18970	COG0515	serine threonine protein kinase
HG15A2_RS18970	COG2815	serine threonine protein kinase
HG15A2_RS18975	COG0385	Bile acid
HG15A2_RS18985	COG2204	response regulator
HG15A2_RS18990	COG4191	Histidine kinase
HG15A2_RS19020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HG15A2_RS19075	COG0646	methionine synthase
HG15A2_RS19075	COG1410	methionine synthase
HG15A2_RS19080	COG0129	dihydroxy-acid dehydratase activity
HG15A2_RS19170	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HG15A2_RS19170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HG15A2_RS19175	COG1691	(AIR) carboxylase
HG15A2_RS19270	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS19275	COG0657	acetylesterase activity
HG15A2_RS19315	COG2130	NADP-dependent
HG15A2_RS19325	COG3237	CsbD-like
HG15A2_RS19345	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HG15A2_RS19350	COG3621	Patatin-like phospholipase
HG15A2_RS19360	COG0281	malic enzyme
HG15A2_RS19405	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG15A2_RS19415	COG0306	phosphate transporter
HG15A2_RS19425	COG2226	methyltransferase
HG15A2_RS19495	COG1960	acyl-CoA dehydrogenase activity
HG15A2_RS19500	COG0529	Catalyzes the synthesis of activated sulfate
HG15A2_RS19510	COG1663	tetraacyldisaccharide 4'-kinase activity
HG15A2_RS19520	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HG15A2_RS19525	COG1131	(ABC) transporter
HG15A2_RS19545	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HG15A2_RS19585	COG4941	Belongs to the sigma-70 factor family
HG15A2_RS19600	COG3795	YCII-related domain
HG15A2_RS19605	COG3795	YCII-related domain
HG15A2_RS19640	COG1459	type II secretion system
HG15A2_RS19700	COG1175	transmembrane transport
HG15A2_RS19705	COG0395	ABC-type sugar transport system, permease component
HG15A2_RS19710	COG3842	ATPase activity
HG15A2_RS19755	COG3119	arylsulfatase activity
HG15A2_RS19765	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HG15A2_RS19770	COG0584	glycerophosphoryl diester phosphodiesterase
HG15A2_RS19790	COG3119	arylsulfatase activity
HG15A2_RS19800	COG0584	glycerophosphoryl diester phosphodiesterase
HG15A2_RS19810	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HG15A2_RS19815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HG15A2_RS19835	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS19840	COG4251	negative regulation of phosphorylation
HG15A2_RS19865	COG0069	glutamate synthase activity
HG15A2_RS19905	COG0363	glucosamine-6-phosphate deaminase activity
HG15A2_RS19910	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HG15A2_RS19910	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HG15A2_RS19950	COG2211	Major facilitator Superfamily
HG15A2_RS19965	COG3328	transposase activity
HG15A2_RS19990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HG15A2_RS20050	COG0167	dihydroorotate dehydrogenase activity
HG15A2_RS20050	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HG15A2_RS20060	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HG15A2_RS20075	COG1012	belongs to the aldehyde dehydrogenase family
HG15A2_RS20095	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_RS20095	COG3347	Dehydrogenase
HG15A2_RS20110	COG3119	arylsulfatase activity
HG15A2_RS20125	COG3119	arylsulfatase activity
HG15A2_RS20130	COG3119	arylsulfatase activity
HG15A2_RS20135	COG3119	arylsulfatase activity
HG15A2_RS20185	COG1940	carbohydrate kinase activity
HG15A2_RS20240	COG3119	arylsulfatase activity
HG15A2_RS20250	COG1472	Belongs to the glycosyl hydrolase 3 family
HG15A2_RS20255	COG1595	DNA-templated transcription, initiation
HG15A2_RS20285	COG3119	arylsulfatase activity
HG15A2_RS20400	COG3119	arylsulfatase activity
HG15A2_RS20410	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG15A2_RS20430	COG3119	arylsulfatase activity
HG15A2_RS20440	COG3119	arylsulfatase activity
HG15A2_RS20440	COG3408	Glycogen debranching enzyme
HG15A2_RS20460	COG3119	arylsulfatase activity
HG15A2_RS20465	COG3119	arylsulfatase activity
HG15A2_RS20470	COG3119	arylsulfatase activity
HG15A2_RS20475	COG3119	arylsulfatase activity
HG15A2_RS20490	COG1082	Xylose isomerase domain protein TIM barrel
HG15A2_RS20495	COG4948	Mandelate Racemase Muconate Lactonizing
HG15A2_RS20505	COG3119	arylsulfatase activity
HG15A2_RS20515	COG3119	arylsulfatase activity
HG15A2_RS20555	COG3119	arylsulfatase activity
HG15A2_RS20560	COG1164	Oligoendopeptidase f
HG15A2_RS20565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HG15A2_RS20580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HG15A2_RS20590	COG0107	imidazoleglycerol-phosphate synthase activity
HG15A2_RS20600	COG4067	protein conserved in archaea
HG15A2_RS20600	COG0189	ligase activity
HG15A2_RS20605	COG0189	ligase activity
HG15A2_RS20630	COG2022	thiamine diphosphate biosynthetic process
HG15A2_RS20635	COG1199	ATP-dependent helicase activity
HG15A2_RS20670	COG2442	InterPro IPR007367
HG15A2_RS20675	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HG15A2_RS20685	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HG15A2_RS20690	COG0163	prenyltransferase activity
HG15A2_RS20700	COG2226	methyltransferase
HG15A2_RS20705	COG2045	Belongs to the ComB family
HG15A2_RS20710	COG0423	glycine-tRNA ligase activity
HG15A2_RS20735	COG2267	carboxylic ester hydrolase activity
HG15A2_RS20750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HG15A2_RS20785	COG3177	Filamentation induced by cAMP protein fic
HG15A2_RS20815	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HG15A2_RS20845	COG0189	ligase activity
HG15A2_RS20845	COG4067	protein conserved in archaea
HG15A2_RS20850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HG15A2_RS20860	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HG15A2_RS20865	COG1704	LemA family
HG15A2_RS20870	COG0501	Belongs to the peptidase M48B family
HG15A2_RS20875	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HG15A2_RS20880	COG0519	Catalyzes the synthesis of GMP from XMP
HG15A2_RS20890	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HG15A2_RS20905	COG0347	Belongs to the P(II) protein family
HG15A2_RS20915	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HG15A2_RS20925	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HG15A2_RS20945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG15A2_RS20950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HG15A2_RS20960	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HG15A2_RS20965	COG0242	peptide deformylase activity
HG15A2_RS20975	COG0811	peptide transport
HG15A2_RS21040	COG0714	Associated with various cellular activities
HG15A2_RS21065	COG1247	-acetyltransferase
HG15A2_RS21080	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG15A2_RS21085	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG15A2_RS21090	COG1321	iron dependent repressor
HG15A2_RS21140	COG3237	CsbD-like
HG15A2_RS21165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG15A2_RS21190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HG15A2_RS21200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HG15A2_RS21205	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HG15A2_RS21210	COG1449	Belongs to the glycosyl hydrolase 57 family
HG15A2_RS21220	COG0297	glycogen (starch) synthase activity
HG15A2_RS21240	COG0513	Belongs to the DEAD box helicase family
HG15A2_RS21250	COG1840	ABC-type Fe3 transport system, periplasmic component
HG15A2_RS21255	COG1234	tRNA 3'-trailer cleavage
HG15A2_RS21275	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HG15A2_RS21285	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
HG15A2_RS21305	COG0277	FAD linked oxidase domain protein
HG15A2_RS21315	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HG15A2_RS21335	COG0142	geranyltranstransferase activity
HG15A2_RS21360	COG0438	transferase activity, transferring glycosyl groups
HG15A2_RS21365	COG4191	Histidine kinase
HG15A2_RS21370	COG4566	intracellular signal transduction
HG15A2_RS21380	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HG15A2_RS21395	COG1136	(ABC) transporter
HG15A2_RS21445	COG0542	response to heat
HG15A2_RS21455	COG0352	thiamine-phosphate diphosphorylase activity
HG15A2_RS21470	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HG15A2_RS21490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HG15A2_RS21495	COG0489	protein tyrosine kinase activity
HG15A2_RS21510	COG1994	Peptidase M50
HG15A2_RS21515	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG15A2_RS21525	COG4284	Utp--glucose-1-phosphate uridylyltransferase
HG15A2_RS21530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HG15A2_RS21540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HG15A2_RS21545	COG0215	cysteine-tRNA ligase activity
HG15A2_RS21560	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HG15A2_RS21565	COG0632	four-way junction helicase activity
HG15A2_RS21570	COG1073	alpha beta
HG15A2_RS21595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HG15A2_RS21615	COG0442	prolyl-tRNA aminoacylation
HG15A2_RS21635	COG0557	exoribonuclease II activity
HG15A2_RS21640	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HG15A2_RS21645	COG0509	glycine decarboxylation via glycine cleavage system
HG15A2_RS21650	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG15A2_RS21660	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG15A2_RS21670	COG0515	serine threonine protein kinase
HG15A2_RS21670	COG0457	Tetratricopeptide repeat
HG15A2_RS21675	COG0457	Tetratricopeptide repeat
HG15A2_RS21675	COG0515	serine threonine protein kinase
HG15A2_RS21680	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG15A2_RS21685	COG0095	Lipoate-protein ligase
HG15A2_RS21725	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HG15A2_RS21730	COG3239	Fatty acid desaturase
HG15A2_RS21770	COG1819	glycosyl
HG15A2_RS21790	COG0671	phosphoesterase, PA-phosphatase related
HG15A2_RS21870	COG2815	serine threonine protein kinase
HG15A2_RS21870	COG0515	serine threonine protein kinase
HG15A2_RS21875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HG15A2_RS21890	COG0058	SHG alpha-glucan phosphorylase activity
HG15A2_RS22000	COG0521	Mo-molybdopterin cofactor biosynthetic process
HG15A2_RS22115	COG1943	Transposase
HG15A2_RS22120	COG2010	Cytochrome c
HG15A2_RS22130	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG15A2_RS22140	COG0745	RESPONSE REGULATOR receiver
HG15A2_RS22145	COG0745	RESPONSE REGULATOR receiver
HG15A2_RS22145	COG2205	protein histidine kinase activity
HG15A2_RS22145	COG3292	Two component regulator propeller
HG15A2_RS22150	COG1943	Transposase
HG15A2_RS22165	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HG15A2_RS22195	COG1595	DNA-templated transcription, initiation
HG15A2_RS22205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HG15A2_RS22210	COG1511	domain protein
HG15A2_RS22210	COG3264	Mechanosensitive ion channel
HG15A2_RS22275	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG15A2_RS22280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HG15A2_RS22285	COG0616	signal peptide processing
HG15A2_RS22300	COG0750	zinc metalloprotease
HG15A2_RS22305	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HG15A2_RS22310	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HG15A2_RS22320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HG15A2_RS22325	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HG15A2_RS22420	COG0601	transmembrane transport
HG15A2_RS22425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HG15A2_RS22465	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HG15A2_RS22470	COG1090	epimerase
HG15A2_RS22480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG15A2_RS22505	COG0187	DNA topoisomerase II activity
HG15A2_RS22545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HG15A2_RS22550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HG15A2_RS22555	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HG15A2_RS22565	COG1530	ribonuclease E activity
HG15A2_RS22590	COG0758	DNA mediated transformation
HG15A2_RS22595	COG1595	DNA-templated transcription, initiation
HG15A2_RS22630	COG4172	Belongs to the ABC transporter superfamily
HG15A2_RS22640	COG2062	phosphohistidine phosphatase, SixA
HG15A2_RS22660	COG5487	UPF0391 membrane protein
HG15A2_RS22670	COG0822	iron-sulfur transferase activity
HG15A2_RS22675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HG15A2_RS22690	COG1858	cytochrome C peroxidase
HG15A2_RS22695	COG0450	alkyl hydroperoxide reductase
HG15A2_RS22700	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HG15A2_RS22705	COG0673	inositol 2-dehydrogenase activity
HG15A2_RS22735	COG1192	Involved in chromosome partitioning
HG15A2_RS22750	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HG15A2_RS22780	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG15A2_RS22785	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HG15A2_RS22790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG15A2_RS22795	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HG15A2_RS22820	COG0659	secondary active sulfate transmembrane transporter activity
HG15A2_RS22860	COG0530	calcium, potassium:sodium antiporter activity
HG15A2_RS22965	COG0191	fructose-bisphosphate aldolase activity
HG15A2_RS22980	COG0203	ribosomal protein L17
HG15A2_RS22985	COG0202	RNA polymerase activity
HG15A2_RS22990	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HG15A2_RS22995	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HG15A2_RS23000	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HG15A2_RS23005	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HG15A2_RS23015	COG0563	adenylate kinase activity
HG15A2_RS23020	COG0201	protein transport
HG15A2_RS23025	COG0200	Binds to the 23S rRNA
HG15A2_RS23030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HG15A2_RS23035	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HG15A2_RS23040	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HG15A2_RS23045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HG15A2_RS23050	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HG15A2_RS23055	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG15A2_RS23060	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HG15A2_RS23065	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HG15A2_RS23075	COG0255	Belongs to the universal ribosomal protein uL29 family
HG15A2_RS23080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HG15A2_RS23085	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HG15A2_RS23090	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HG15A2_RS23095	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HG15A2_RS23100	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HG15A2_RS23105	COG0089	rRNA binding
HG15A2_RS23110	COG0088	Forms part of the polypeptide exit tunnel
HG15A2_RS23115	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HG15A2_RS23120	COG0051	transcription antitermination factor activity, RNA binding
HG15A2_RS23125	COG3707	response regulator
HG15A2_RS23130	COG3237	CsbD-like
HG15A2_RS23170	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG15A2_RS23175	COG0049	tRNA binding
HG15A2_RS23180	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HG15A2_RS23185	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HG15A2_RS23190	COG0085	RNA polymerase activity
HG15A2_RS23195	COG0222	ribosome binding
HG15A2_RS23200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HG15A2_RS23205	COG0081	regulation of translation
HG15A2_RS23210	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HG15A2_RS23215	COG0250	Participates in transcription elongation, termination and antitermination
HG15A2_RS23230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HG15A2_RS23280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG15A2_RS23290	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HG15A2_RS23305	COG1598	PFAM Uncharacterised protein family UPF0150
HG15A2_RS23470	COG1733	regulation of RNA biosynthetic process
HG15A2_RS23525	COG0438	transferase activity, transferring glycosyl groups
HG15A2_RS23535	COG3177	Filamentation induced by cAMP protein fic
HG15A2_RS23550	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HG15A2_RS23555	COG0517	IMP dehydrogenase activity
HG15A2_RS23555	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HG15A2_RS23570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HG15A2_RS23575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG15A2_RS23600	COG1012	belongs to the aldehyde dehydrogenase family
HG15A2_RS23620	COG1704	LemA family
HG15A2_RS23635	COG0165	Argininosuccinate lyase
HG15A2_RS23645	COG2204	response regulator
HG15A2_RS23655	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HG15A2_RS23665	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HG15A2_RS23715	COG4464	protein tyrosine phosphatase activity
HG15A2_RS23845	COG1757	Na H antiporter
HG15A2_RS24075	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HG15A2_RS24145	COG0318	PFAM AMP-dependent synthetase and ligase
HG15A2_RS24210	COG1862	Preprotein translocase
HG15A2_RS24220	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_RS24430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HG15A2_RS24505	COG3876	Protein conserved in bacteria
HG15A2_RS24580	COG1028	Short-chain dehydrogenase reductase Sdr
HG15A2_RS24595	COG2963	transposase activity
HG15A2_RS24655	COG0653	protein targeting
HG15A2_RS24675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG15A2_RS24675	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG15A2_RS24705	COG0657	acetylesterase activity
HG15A2_RS24780	COG0228	four-way junction DNA binding
HG15A2_RS24795	COG2165	general secretion pathway protein
HG15A2_RS24815	COG3328	transposase activity