locus-tag	class	description
HUW48_RS00020	ENOG4105C7H	Helicase, RecD TraA family
HUW48_RS00040	ENOG4105HDD	phospholipase
HUW48_RS00050	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HUW48_RS00090	ENOG4105ECQ	AraC Family Transcriptional Regulator
HUW48_RS00120	ENOG4105VEQ	Cold shock protein
HUW48_RS00145	ENOG41089UC	methyltransferase, type 11
HUW48_RS00155	ENOG4105D6J	arsenicaL-resistance protein
HUW48_RS00165	ENOG4105KK4	UPF0060 membrane protein
HUW48_RS00170	ENOG4105C59	p-type ATPase
HUW48_RS00180	ENOG41090R7	Ferric uptake
HUW48_RS00215	ENOG4108IJF	Heavy metal efflux pump, CzcA
HUW48_RS00295	ENOG4105C59	p-type ATPase
HUW48_RS00300	ENOG4108IMY	Transcriptional regulator
HUW48_RS00325	ENOG4105KT5	UmuD protein
HUW48_RS00355	ENOG4105E4C	Lytic transglycosylase catalytic
HUW48_RS00465	ENOG4107QJE	Chromosome Partitioning Protein
HUW48_RS00520	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
HUW48_RS00525	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
HUW48_RS00550	ENOG4105EKQ	RNA-directed DNA polymerase
HUW48_RS00560	ENOG4108C33	Resolvase
HUW48_RS00615	ENOG4107S2Z	UPF0761 membrane protein
HUW48_RS00620	ENOG4105EEQ	Na H antiporter
HUW48_RS00680	ENOG4108MCI	Transcriptional regulator, ARAC family
HUW48_RS00700	ENOG4105CHR	reductase
HUW48_RS00715	ENOG4105BZU	Histidine kinase
HUW48_RS00725	ENOG4105BZU	Histidine kinase
HUW48_RS00730	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HUW48_RS00735	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HUW48_RS00795	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
HUW48_RS00805	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
HUW48_RS00835	ENOG4105D4P	Coproporphyrinogen iii oxidase
HUW48_RS00865	ENOG4108M24	von Willebrand factor, type A
HUW48_RS00890	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HUW48_RS00915	ENOG4105ECQ	AraC Family Transcriptional Regulator
HUW48_RS00940	ENOG4107PMW	Arabinan endo-1,5-alpha-L-arabinosidase
HUW48_RS00945	ENOG41063V1	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HUW48_RS00955	ENOG4105IGJ	Zn-dependent Hydrolase of the beta-lactamase fold protein
HUW48_RS00980	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
HUW48_RS00985	ENOG4105ECQ	AraC Family Transcriptional Regulator
HUW48_RS01005	ENOG4105CHR	reductase
HUW48_RS01015	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
HUW48_RS01050	ENOG41082W1	Cupin 2, conserved barrel domain protein
HUW48_RS01075	ENOG4107RBB	ABC transporter, permease
HUW48_RS01080	ENOG4107RBB	ABC transporter, permease
HUW48_RS01085	ENOG4107RBB	ABC transporter, permease
HUW48_RS01090	ENOG4107RBB	ABC transporter, permease
HUW48_RS01100	ENOG4107RBB	ABC transporter, permease
HUW48_RS01120	ENOG4105WH1	Two component transcriptional regulator luxr family
HUW48_RS01135	ENOG4105KVH	Transcriptional regulator
HUW48_RS01150	ENOG4107RBB	ABC transporter, permease
HUW48_RS01155	ENOG4107RBB	ABC transporter, permease
HUW48_RS01160	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HUW48_RS01180	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HUW48_RS01185	ENOG4107RBB	ABC transporter, permease
HUW48_RS01190	ENOG4107RBB	ABC transporter, permease
HUW48_RS01200	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
HUW48_RS01205	ENOG4105BZP	glycoside hydrolase 15-related
HUW48_RS01225	ENOG4105TT1	Ragb susd domain-containing protein
HUW48_RS01235	ENOG4105E08	Glycoside hydrolase, family 9
HUW48_RS01280	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HUW48_RS01285	ENOG4105CPC	Aldo Keto reductase
HUW48_RS01315	ENOG4105CGD	Nad-dependent epimerase dehydratase
HUW48_RS01330	ENOG4108KF3	Electron transport protein SCO1 SenC
HUW48_RS01345	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HUW48_RS01350	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HUW48_RS01355	ENOG4105CUK	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
HUW48_RS01360	ENOG4107PMW	Arabinan endo-1,5-alpha-L-arabinosidase
HUW48_RS01370	ENOG4105W2Z	cytochrome C, class I
HUW48_RS01375	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HUW48_RS01380	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HUW48_RS01385	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
HUW48_RS01390	ENOG4105D9R	oxidoreductase
HUW48_RS01395	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HUW48_RS01450	ENOG4105DI5	UPF0365 protein
HUW48_RS01465	ENOG4106UW1	Major Facilitator superfamily
HUW48_RS01475	ENOG4105C2M	dna polymerase I
HUW48_RS01515	ENOG4108V0P	LemA family
HUW48_RS01535	ENOG4105WDY	DNA (cytosine-5-)-methyltransferase
HUW48_RS01560	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HUW48_RS01565	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HUW48_RS01580	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HUW48_RS01590	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HUW48_RS01595	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HUW48_RS01600	ENOG4107YAY	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HUW48_RS01605	ENOG4105K5M	30s ribosomal protein S16
HUW48_RS01615	ENOG4105CKK	Glycosyl transferase, family 2
HUW48_RS01620	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HUW48_RS01635	ENOG4105C34	Pseudouridine synthase
HUW48_RS01640	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HUW48_RS01650	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HUW48_RS01660	ENOG4107QX3	carboxylase
HUW48_RS01670	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HUW48_RS01675	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
HUW48_RS01680	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HUW48_RS01685	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HUW48_RS01705	ENOG41063TF	transcriptional regulator (AraC
HUW48_RS01715	ENOG4108W6C	Dehydrogenase
HUW48_RS01720	ENOG4108W6C	Dehydrogenase
HUW48_RS01730	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HUW48_RS01735	ENOG4108R99	pseudouridine synthase
HUW48_RS01740	ENOG4105CFG	Acts as a chaperone (By similarity)
HUW48_RS01745	ENOG4105ENE	Histidine kinase
HUW48_RS01755	ENOG4105WH1	Two component transcriptional regulator luxr family
HUW48_RS01770	ENOG4105BZU	Histidine kinase
HUW48_RS01800	ENOG4105D4Y	metalloprotease
HUW48_RS01820	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HUW48_RS01825	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
HUW48_RS01840	ENOG4105E9K	Isocitrate dehydrogenase
HUW48_RS01850	ENOG4105C2X	Arabinose 5-phosphate isomerase
HUW48_RS01855	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HUW48_RS01860	ENOG4105C12	Phosphoribosylglycinamide synthetase
HUW48_RS01865	ENOG4108Y6J	UPF0403 protein
HUW48_RS01870	ENOG4105CUJ	penicillin amidase
HUW48_RS01925	ENOG4105DA2	glyoxalase bleomycin resistance protein dioxygenase
HUW48_RS01930	ENOG4108YYC	ycei family
HUW48_RS01940	ENOG4105DFK	Polyphosphate glucokinase
HUW48_RS01945	ENOG4105D8V	Glucose sorbosone dehydrogenase
HUW48_RS01950	ENOG4105U5Y	Transcriptional regulator
HUW48_RS01980	ENOG4105CZQ	inner membrane transport protein YdhC
HUW48_RS02005	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HUW48_RS02020	ENOG41080R2	UPF0102 protein
HUW48_RS02025	ENOG4107QP8	phosphohexose isomerase
HUW48_RS02030	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HUW48_RS02060	ENOG4105E6M	Sulphatase-modifying factor protein
HUW48_RS02085	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HUW48_RS02110	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HUW48_RS02120	ENOG4107Z65	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
HUW48_RS02125	ENOG4107Z4P	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HUW48_RS02130	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HUW48_RS02135	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HUW48_RS02140	ENOG4105WMR	Protein CrcB homolog
HUW48_RS02145	ENOG4105F0N	pyrophosphate phospho-hydrolase
HUW48_RS02155	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HUW48_RS02175	ENOG4107UWA	esterase
HUW48_RS02180	ENOG4108YYH	Nadph-dependent fmn reductase
HUW48_RS02190	ENOG4105C5H	ABC transporter
HUW48_RS02195	ENOG4105JAB	phenazine biosynthesis protein, phzf family
HUW48_RS02210	ENOG4108UMS	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity)
HUW48_RS02220	ENOG4105E2D	ec 3.2.1.52
HUW48_RS02250	ENOG4107RAQ	aminopeptidase
HUW48_RS02255	ENOG4105C0H	protease
HUW48_RS02285	ENOG4105DZG	Dehydrogenase
HUW48_RS02305	ENOG4105D44	asparaginase
HUW48_RS02315	ENOG4105BZU	Histidine kinase
HUW48_RS02325	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HUW48_RS02335	ENOG4105W2Z	cytochrome C, class I
HUW48_RS02360	ENOG41089UC	methyltransferase, type 11
HUW48_RS02400	ENOG4105DA4	cytochrome c-type biogenesis protein
HUW48_RS02405	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HUW48_RS02415	ENOG4105VEQ	Cold shock protein
HUW48_RS02430	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HUW48_RS02435	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HUW48_RS02440	ENOG4105DFF	Rod shape-determining protein mreb
HUW48_RS02455	ENOG4105CJN	penicillin-binding protein
HUW48_RS02460	ENOG4105CNI	cell division protein FtsW
HUW48_RS02475	ENOG4105CE4	GlcNAc 6-P deacetylase
HUW48_RS02485	ENOG4105EPC	oxidoreductase
HUW48_RS02495	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HUW48_RS02580	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
HUW48_RS02585	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
HUW48_RS02590	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HUW48_RS02605	ENOG4105DDQ	anthranilate synthase
HUW48_RS02625	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HUW48_RS02640	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HUW48_RS02645	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUW48_RS02660	ENOG4105C34	Pseudouridine synthase
HUW48_RS02670	ENOG4105CVA	phosphate
HUW48_RS02685	ENOG4109015	Biopolymer transport protein exbD tolR
HUW48_RS02700	ENOG4105DXN	mazG family
HUW48_RS02705	ENOG4107QKV	phosphomannomutase
HUW48_RS02710	ENOG4107QI6	Cysteine desulfurase
HUW48_RS02715	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HUW48_RS02720	ENOG4108URH	decarboxylase
HUW48_RS02725	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HUW48_RS02730	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HUW48_RS02735	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HUW48_RS02755	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HUW48_RS02765	ENOG41088SP	formiminoglutamate hydrolase
HUW48_RS02770	ENOG4108IQE	Amp-dependent synthetase and ligase
HUW48_RS02785	ENOG4105CHU	acetyl-coa acetyltransferase
HUW48_RS02795	ENOG4105C1G	acyl-Coa dehydrogenase
HUW48_RS02815	ENOG4108JU5	Magnesium and cobalt efflux protein
HUW48_RS02820	ENOG4108UUM	single-stranded DNA-binding protein
HUW48_RS02825	ENOG4105CEN	a g-specific adenine glycosylase
HUW48_RS02830	ENOG4105K70	DNA-binding protein
HUW48_RS02840	ENOG4105C03	ribonuclease
HUW48_RS02865	ENOG4105D52	delta-aminolevulinic acid dehydratase
HUW48_RS02880	ENOG4106HB6	Alpha beta hydrolase
HUW48_RS02890	ENOG4105KME	endoribonuclease L-psp
HUW48_RS02895	ENOG4105C1Y	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity)
HUW48_RS02925	ENOG4107T8J	thymidine kinase
HUW48_RS02940	ENOG41060VI	Involved in DNA repair and RecF pathway recombination (By similarity)
HUW48_RS02950	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HUW48_RS02955	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HUW48_RS02960	ENOG4105SFS	phosphoesterase RecJ domain protein
HUW48_RS02965	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HUW48_RS02975	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
HUW48_RS02980	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HUW48_RS02985	ENOG4105CHV	Transcription elongation factor NusA
HUW48_RS03000	ENOG4105C8N	cysteinyl-tRNA synthetase
HUW48_RS03005	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
HUW48_RS03010	ENOG4105D6E	homoserine dehydrogenase
HUW48_RS03015	ENOG4105DWV	Homoserine O-trans-acetylase
HUW48_RS03020	ENOG4108IQK	o-acetylhomoserine
HUW48_RS03025	ENOG4105D9N	nucleoside
HUW48_RS03035	ENOG4108Z6B	deaminase
HUW48_RS03050	ENOG4105C9M	aspartyl-trna synthetase
HUW48_RS03055	ENOG4108VVK	transcriptional Regulator, AsnC
HUW48_RS03075	ENOG4105E4I	Glycoside hydrolase family 28
HUW48_RS03090	ENOG4107TDE	lipolytic protein G-D-S-L family
HUW48_RS03095	ENOG4107TDE	lipolytic protein G-D-S-L family
HUW48_RS03135	ENOG4105CHR	reductase
HUW48_RS03140	ENOG4105D50	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity)
HUW48_RS03145	ENOG4107XII	Glycosyl Hydrolase Family 88
HUW48_RS03150	ENOG4107QZW	Altronate oxidoreductase
HUW48_RS03155	ENOG4105CTX	dehydratase
HUW48_RS03160	ENOG4105D2H	Uronic isomerase
HUW48_RS03165	ENOG4105DPW	Major facilitator superfamily MFS_1
HUW48_RS03175	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HUW48_RS03180	ENOG4105ETE	Transcriptional regulator (LacI family
HUW48_RS03185	ENOG4107TDE	lipolytic protein G-D-S-L family
HUW48_RS03250	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
HUW48_RS03330	ENOG4105DYC	esterase
HUW48_RS03335	ENOG4105DYC	esterase
HUW48_RS03355	ENOG4107QP7	CoA-transferase subunit A
HUW48_RS03365	ENOG4105DYC	esterase
HUW48_RS03375	ENOG4105EBR	Carboxylesterase
HUW48_RS03380	ENOG4105D4T	Citrate transporter
HUW48_RS03400	ENOG4105DZG	Dehydrogenase
HUW48_RS03450	ENOG4105WH1	Two component transcriptional regulator luxr family
HUW48_RS03455	ENOG4105BZU	Histidine kinase
HUW48_RS03460	ENOG4107QZF	nitrite reductase NADPH large subunit
HUW48_RS03475	ENOG4107RNU	major facilitator superfamily MFS_1
HUW48_RS03515	ENOG4108ZAF	Molybdopterin
HUW48_RS03525	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HUW48_RS03530	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HUW48_RS03535	ENOG4105C8S	subunit m
HUW48_RS03540	ENOG4105D65	subunit l
HUW48_RS03545	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HUW48_RS03555	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HUW48_RS03560	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HUW48_RS03580	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HUW48_RS03585	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HUW48_RS03590	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HUW48_RS03595	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HUW48_RS03605	ENOG4105C26	Dehydrogenase
HUW48_RS03625	ENOG4105C28	cystathionine
HUW48_RS03635	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HUW48_RS03650	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HUW48_RS03655	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HUW48_RS03665	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
HUW48_RS03670	ENOG41081WG	50s ribosomal protein l31
HUW48_RS03675	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HUW48_RS03685	ENOG4107QRG	dna polymerase iii
HUW48_RS03690	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HUW48_RS03715	ENOG4105C25	Primosomal protein n'
HUW48_RS03720	ENOG4105C7Z	Conserved Protein
HUW48_RS03730	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HUW48_RS03735	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HUW48_RS03740	ENOG41080B9	Binds together with S18 to 16S ribosomal RNA (By similarity)
HUW48_RS03750	ENOG4107SFQ	iron-sulfur binding
HUW48_RS03780	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HUW48_RS03790	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HUW48_RS03795	ENOG4107R3R	Cytochrome o ubiquinol oxidase subunit III
HUW48_RS03800	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
HUW48_RS03810	ENOG4108KF3	Electron transport protein SCO1 SenC
HUW48_RS03815	ENOG4108SJC	Membrane
HUW48_RS03865	ENOG4108VHC	Short-chain dehydrogenase reductase Sdr
HUW48_RS03870	ENOG4105NBK	UPF0345 protein
HUW48_RS03885	ENOG4105CY0	Metallo-Beta-Lactamase
HUW48_RS03890	ENOG4105W2Z	cytochrome C, class I
HUW48_RS03905	ENOG4105C1V	Peptidase, M16
HUW48_RS03915	ENOG4107RAQ	aminopeptidase
HUW48_RS03920	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HUW48_RS03940	ENOG4105EYH	Exonuclease
HUW48_RS03960	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
HUW48_RS03980	ENOG4105IIU	Aminopeptidase
HUW48_RS03985	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HUW48_RS04000	ENOG4105DAP	Nicotinate phosphoribosyltransferase
HUW48_RS04010	ENOG4105DEN	Luciferase family
HUW48_RS04020	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HUW48_RS04045	ENOG4105E6M	Sulphatase-modifying factor protein
HUW48_RS04050	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HUW48_RS04055	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
HUW48_RS04075	ENOG4105DY9	regulatoR
HUW48_RS04080	ENOG4108HRK	Histidine kinase
HUW48_RS04090	ENOG4105C8Y	Acetylornithine aminotransferase
HUW48_RS04100	ENOG4105KDC	50s ribosomal protein l28
HUW48_RS04105	ENOG4107RAQ	aminopeptidase
HUW48_RS04110	ENOG4107QJZ	Glycosyl transferase, family 2
HUW48_RS04115	ENOG41083ND	50S ribosomal protein L33
HUW48_RS04125	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HUW48_RS04135	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HUW48_RS04140	ENOG41074B2	UPF0747 protein
HUW48_RS04145	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HUW48_RS04150	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HUW48_RS04175	ENOG4105EUB	pirin domain protein
HUW48_RS04185	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HUW48_RS04210	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HUW48_RS04220	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HUW48_RS04225	ENOG4105BZU	Histidine kinase
HUW48_RS04230	ENOG4105EI2	Pseudouridine synthase
HUW48_RS04240	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HUW48_RS04245	ENOG4108UJD	30S ribosomal protein S9
HUW48_RS04250	ENOG4105CE9	30S ribosomal protein S2
HUW48_RS04255	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HUW48_RS04275	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HUW48_RS04280	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
HUW48_RS04285	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
HUW48_RS04290	ENOG4108ZBE	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity)
HUW48_RS04305	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HUW48_RS04320	ENOG4105C37	(CBS) domain
HUW48_RS04330	ENOG4105CSM	endonuclease III
HUW48_RS04335	ENOG4107QJZ	Glycosyl transferase, family 2
HUW48_RS04340	ENOG4105EMN	RNA polymerase sigma factor
HUW48_RS04345	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HUW48_RS04355	ENOG4108FN7	Aldo keto reductase
HUW48_RS04380	ENOG4105W5Q	DNA repair protein (RadC
HUW48_RS04390	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HUW48_RS04405	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
HUW48_RS04420	ENOG4105ETE	Transcriptional regulator (LacI family
HUW48_RS04430	ENOG4105TT1	Ragb susd domain-containing protein
HUW48_RS04435	ENOG4105E2D	ec 3.2.1.52
HUW48_RS04440	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HUW48_RS04470	ENOG41066UZ	arginase EC 3.5.3.1
HUW48_RS04510	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HUW48_RS04525	ENOG4105D3Q	Sugar transferase
HUW48_RS04535	ENOG4105E2K	Glycosyl transferase (Group 1
HUW48_RS04545	ENOG4107TYR	Glycosyl Transferase
HUW48_RS04555	ENOG4105K64	Glycosyl transferase, family 2
HUW48_RS04570	ENOG4105D75	Capsular exopolysaccharide family
HUW48_RS04605	ENOG4105CHU	acetyl-coa acetyltransferase
HUW48_RS04610	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HUW48_RS04615	ENOG4105BZ1	(ABC) transporter
HUW48_RS04625	ENOG4105CSA	Coproporphyrinogen iii oxidase
HUW48_RS04680	ENOG4105EPC	oxidoreductase
HUW48_RS04695	ENOG4105D8V	Glucose sorbosone dehydrogenase
HUW48_RS04715	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HUW48_RS04725	ENOG4105E70	isomerase
HUW48_RS04735	ENOG4108PWI	heparinase ii
HUW48_RS04745	ENOG4105D2N	Aldolase
HUW48_RS04755	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
HUW48_RS04780	ENOG4105E98	transcriptional regulator DeoR family
HUW48_RS04790	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HUW48_RS04800	ENOG4107RH8	nuclease SbcCD subunit D
HUW48_RS04805	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HUW48_RS04810	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HUW48_RS04815	ENOG4107THF	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HUW48_RS04855	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HUW48_RS04860	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
HUW48_RS04865	ENOG4108Z2K	Cupin 2, conserved barrel domain protein
HUW48_RS04870	ENOG4105VDW	Csbd family
HUW48_RS04880	ENOG4105CRK	lysyL-tRNA synthetase
HUW48_RS04920	ENOG4105E4T	pyridine nucleotide-disulfide oxidoreductase
HUW48_RS04960	ENOG4108SHN	Glycosyl transferase, family 2
HUW48_RS05005	ENOG4108Z90	colanic acid biosynthesis acetyltransferase wcaF
HUW48_RS05010	ENOG4106WTF	Glycosyl transferase, family 2
HUW48_RS05025	ENOG4106CD9	glycosyl transferase group 1
HUW48_RS05065	ENOG4105EY8	ABC transporter
HUW48_RS05075	ENOG4105K64	Glycosyl transferase, family 2
HUW48_RS05080	ENOG4107BJW	polysaccharide deacetylase
HUW48_RS05090	ENOG4107S6X	Glycosyl transferase, family 2
HUW48_RS05110	ENOG4105C30	Nad-dependent epimerase dehydratase
HUW48_RS05115	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
HUW48_RS05120	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HUW48_RS05125	ENOG4105CMR	udp-glucose 4-epimerase
HUW48_RS05145	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HUW48_RS05150	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HUW48_RS05175	ENOG4105KQC	Competence protein
HUW48_RS05190	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HUW48_RS05200	ENOG4105DFH	Transport of potassium into the cell (By similarity)
HUW48_RS05215	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
HUW48_RS05225	ENOG4105C27	TonB-dependent Receptor Plug
HUW48_RS05240	ENOG4105CXK	mandelate racemase muconate lactonizing
HUW48_RS05245	ENOG4105CXK	mandelate racemase muconate lactonizing
HUW48_RS05250	ENOG4105C09	Bile acid
HUW48_RS05260	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HUW48_RS05270	ENOG4105CXK	mandelate racemase muconate lactonizing
HUW48_RS05275	ENOG4105C31	Tryptophanyl-tRNA synthetase
HUW48_RS05285	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
HUW48_RS05295	ENOG4107QWK	SAICAR synthetase
HUW48_RS05300	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HUW48_RS05305	ENOG4105CFH	Aspartokinase
HUW48_RS05315	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HUW48_RS05325	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HUW48_RS05330	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HUW48_RS05335	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HUW48_RS05340	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HUW48_RS05390	ENOG4105EWI	Short-chain dehydrogenase reductase Sdr
HUW48_RS05405	ENOG4105EBR	Carboxylesterase
HUW48_RS05465	ENOG4108MR6	WD40-like Beta Propeller Repeat
HUW48_RS05480	ENOG4108KPZ	tonB-dependent Receptor
HUW48_RS05530	ENOG4107SET	aldo keto reductase
HUW48_RS05560	ENOG4108Z0R	Transferase
HUW48_RS05645	ENOG4105QJH	Domain of unknown function (DUF718)
HUW48_RS05655	ENOG4105CPQ	Dehydrogenase
HUW48_RS05670	ENOG4105MFV	ABC-2 type transporter
HUW48_RS05675	ENOG4105EY8	ABC transporter
HUW48_RS05695	ENOG4105ECJ	Glycosyl Transferase
HUW48_RS05715	ENOG4107R51	Glycosyl transferase, family 2
HUW48_RS05765	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HUW48_RS05770	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HUW48_RS05775	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HUW48_RS05780	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUW48_RS05785	ENOG4107XPB	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUW48_RS05790	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HUW48_RS05795	ENOG4108IUX	(ABC) transporter
HUW48_RS05805	ENOG4105FFC	UPF0187 protein
HUW48_RS05810	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HUW48_RS05825	ENOG4108JQ1	Dehydrogenase
HUW48_RS05840	ENOG4105CPK	Glycosyl transferase (Group 1
HUW48_RS05845	ENOG4105D17	glycoside hydrolase, family 3 domain protein
HUW48_RS05850	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HUW48_RS05875	ENOG4105C11	sulfate adenylyltransferase), subunit 2
HUW48_RS05880	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
HUW48_RS05885	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
HUW48_RS05890	ENOG4105C6T	cysteine synthase
HUW48_RS05910	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
HUW48_RS05915	ENOG4108IAJ	Nad-dependent epimerase dehydratase
HUW48_RS05920	ENOG4105FDR	Membrane
HUW48_RS05930	ENOG4105CPN	adenine deaminase
HUW48_RS05940	ENOG4105CAT	Cytidine monophosphate kinase
HUW48_RS05945	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HUW48_RS05965	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HUW48_RS05970	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HUW48_RS05975	ENOG4105E5N	succinylglutamate desuccinylase aspartoacylase
HUW48_RS05995	ENOG4105K4T	epimerase
HUW48_RS06000	ENOG4105D74	hydrolase
HUW48_RS06025	ENOG4105BZU	Histidine kinase
HUW48_RS06030	ENOG4105ERH	Fumarylacetoacetate hydrolase
HUW48_RS06035	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
HUW48_RS06045	ENOG4105EPC	oxidoreductase
HUW48_RS06085	ENOG4108MR6	WD40-like Beta Propeller Repeat
HUW48_RS06105	ENOG4105EUJ	GTP cyclohydrolase i
HUW48_RS06115	ENOG4105K63	Thioredoxin
HUW48_RS06135	ENOG4105C0B	DNA polymerase III (alpha subunit)
HUW48_RS06155	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
HUW48_RS06180	ENOG4105CHP	RNA polymerase
HUW48_RS06215	ENOG4105CQP	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
HUW48_RS06225	ENOG4108IGT	Dipeptidase
HUW48_RS06255	ENOG4105CZK	Aspartate kinase
HUW48_RS06265	ENOG4108TY5	Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis
HUW48_RS06285	ENOG4107TTA	Xylose isomerase domain protein TIM barrel
HUW48_RS06300	ENOG4105FTV	AraC Family Transcriptional Regulator
HUW48_RS06325	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HUW48_RS06330	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
HUW48_RS06340	ENOG4105DF6	Fe-S oxidoreductase
HUW48_RS06345	ENOG4105DF6	Fe-S oxidoreductase
HUW48_RS06390	ENOG4105BZU	Histidine kinase
HUW48_RS06400	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HUW48_RS06440	ENOG4107R8N	Glycosyl transferase, family 2
HUW48_RS06445	ENOG4108UW5	maltose o-acetyltransferase
HUW48_RS06455	ENOG4105EXC	Acyl-transferase
HUW48_RS06465	ENOG4105K64	Glycosyl transferase, family 2
HUW48_RS06490	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HUW48_RS06495	ENOG4105BZU	Histidine kinase
HUW48_RS06500	ENOG4107QZ7	Cellulose synthase catalytic subunit
HUW48_RS06535	ENOG4105D64	Mechanosensitive ion channel
HUW48_RS06540	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
HUW48_RS06555	ENOG4105YB8	TM2 domain containing protein
HUW48_RS06560	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HUW48_RS06580	ENOG4105CUB	amino acid
HUW48_RS06585	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HUW48_RS06590	ENOG4105I7S	Abortive infection protein
HUW48_RS06595	ENOG4105KNE	Phosphatidate cytidylyltransferase
HUW48_RS06600	ENOG4105CN1	protease
HUW48_RS06605	ENOG4107ZNS	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HUW48_RS06615	ENOG4105C6E	dna polymerase iii
HUW48_RS06625	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HUW48_RS06650	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HUW48_RS06655	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HUW48_RS06660	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
HUW48_RS06705	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HUW48_RS06735	ENOG4105CNG	UPF0061 protein
HUW48_RS06755	ENOG4105EBR	Carboxylesterase
HUW48_RS06785	ENOG4108Z33	Thiol disulfide Interchange Protein
HUW48_RS06850	ENOG4106ZEE	Diacylglycerol kinase
HUW48_RS06905	ENOG4105C9K	Endothelin-converting enzyme 1
HUW48_RS06910	ENOG4105EHZ	conserved protein UCP016719
HUW48_RS06915	ENOG4105D1H	recombination factor protein RarA
HUW48_RS06980	ENOG4105C19	ABC transporter
HUW48_RS06990	ENOG4105BZU	Histidine kinase
HUW48_RS06995	ENOG4105DY9	regulatoR
HUW48_RS07000	ENOG4105BZU	Histidine kinase
HUW48_RS07015	ENOG4105K63	Thioredoxin
HUW48_RS07040	ENOG4105DEN	Luciferase family
HUW48_RS07060	ENOG4107R7I	amino acid
HUW48_RS07070	ENOG4105MGM	doxx family
HUW48_RS07080	ENOG4107P26	
HUW48_RS07110	ENOG4105BZU	Histidine kinase
HUW48_RS07120	ENOG4105KHC	sulfurtransferase
HUW48_RS07140	ENOG4108YYC	ycei family
HUW48_RS07200	ENOG4105N82	Endonuclease
HUW48_RS07225	ENOG4105F4R	Transcriptional regulator mode
HUW48_RS07280	ENOG4107S2Z	UPF0761 membrane protein
HUW48_RS07355	ENOG410836F	Transposase
HUW48_RS07430	ENOG4105DTN	riboflavin biosynthesis protein ribF
HUW48_RS07435	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HUW48_RS07440	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HUW48_RS07450	ENOG4107RJ9	Cell division protein FtsX
HUW48_RS07460	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HUW48_RS07475	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HUW48_RS07480	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HUW48_RS07485	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HUW48_RS07490	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HUW48_RS07495	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HUW48_RS07500	ENOG41084PD	50S ribosomal protein L32
HUW48_RS07510	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HUW48_RS07515	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HUW48_RS07520	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HUW48_RS07525	ENOG4105CJW	magnesium transporter
HUW48_RS07535	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HUW48_RS07570	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HUW48_RS07580	ENOG4107T8T	UPF0173 metal-dependent hydrolase
HUW48_RS07595	ENOG4108ZVT	methylmalonyl-coA epimerase
HUW48_RS07645	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HUW48_RS07655	ENOG4105BZU	Histidine kinase
HUW48_RS07660	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HUW48_RS07665	ENOG4108N5B	2-phosphosulfolactate phosphatase
HUW48_RS07670	ENOG4108ZPQ	MazG nucleotide pyrophosphohydrolase
HUW48_RS07675	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HUW48_RS07685	ENOG4105D7N	magnesium and cobalt transport protein CorA
HUW48_RS07695	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HUW48_RS07710	ENOG4105EGZ	biosynthesis protein
HUW48_RS07715	ENOG4105K64	Glycosyl transferase, family 2
HUW48_RS07755	ENOG4108ZCU	PPIases accelerate the folding of proteins
HUW48_RS07765	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HUW48_RS07770	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HUW48_RS07785	ENOG4105CFH	Aspartokinase
HUW48_RS07800	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HUW48_RS07815	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HUW48_RS07825	ENOG4105EMU	Dehydrogenase
HUW48_RS07840	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
HUW48_RS07845	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HUW48_RS07855	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
HUW48_RS07860	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HUW48_RS07865	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HUW48_RS07870	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HUW48_RS07895	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HUW48_RS07900	ENOG4105CNU	cell division protein FtsK
HUW48_RS07915	ENOG4105CQB	FAD linked oxidase domain protein
HUW48_RS07925	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HUW48_RS07930	ENOG4107SN7	NLP P60 protein
HUW48_RS07940	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HUW48_RS07950	ENOG4105WH1	Two component transcriptional regulator luxr family
HUW48_RS07975	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HUW48_RS07985	ENOG4105NWN	ApaG protein
HUW48_RS07990	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HUW48_RS07995	ENOG4105C3F	Signal peptidase i
HUW48_RS08000	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HUW48_RS08010	ENOG4105FA0	parb-like partition protein
HUW48_RS08015	ENOG4107QJE	Chromosome Partitioning Protein
HUW48_RS08020	ENOG4107W2A	UPF0173 metal-dependent hydrolase
HUW48_RS08025	ENOG4105DEF	Extracellular solute-binding protein, family 5
HUW48_RS08030	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HUW48_RS08035	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HUW48_RS08065	ENOG4105EMN	RNA polymerase sigma factor
HUW48_RS08075	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HUW48_RS08095	ENOG4105QVC	MOSC domain-containing protein
HUW48_RS08105	ENOG4105CJ1	ABC, transporter
HUW48_RS08110	ENOG4107QWP	ABC-2 type transporter
HUW48_RS08115	ENOG4105CJ1	ABC, transporter
HUW48_RS08120	ENOG4105CJ1	ABC, transporter
HUW48_RS08125	ENOG4105D0S	secretion protein (HlyD
HUW48_RS08145	ENOG4105VG1	fes assembly suf system protein
HUW48_RS08150	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HUW48_RS08165	ENOG4105C3K	feS assembly ATPase SufC
HUW48_RS08190	ENOG4105CAY	ferredoxin--nadp reductase
HUW48_RS08205	ENOG4105DR5	peptidase
HUW48_RS08305	ENOG4105C7W	Xanthine dehydrogenase
HUW48_RS08310	ENOG4105DIP	Molybdopterin dehydrogenase FAD-binding
HUW48_RS08315	ENOG4107XKX	isoquinoline 1-oxidoreductase, alpha subunit
HUW48_RS08345	ENOG4108CSZ	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HUW48_RS08355	ENOG4105VEQ	Cold shock protein
HUW48_RS08370	ENOG4105C0D	helicase
HUW48_RS08400	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
HUW48_RS08405	ENOG4105FE9	pseudouridine synthase
HUW48_RS08410	ENOG4105WH1	Two component transcriptional regulator luxr family
HUW48_RS08485	ENOG4105WEF	catalase
HUW48_RS08490	ENOG4107SET	aldo keto reductase
HUW48_RS08510	ENOG4105CIS	alcohol dehydrogenase
HUW48_RS08535	ENOG4105CPD	ethanolamine ammonia-lyase
HUW48_RS08540	ENOG4107FQ9	ethanolamine ammonia-lyase
HUW48_RS08580	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HUW48_RS08590	ENOG4105NAE	bifunctional deaminase-reductase domain protein
HUW48_RS08615	ENOG41062QD	Membrane
HUW48_RS08630	ENOG4105CHU	acetyl-coa acetyltransferase
HUW48_RS08640	ENOG4107QVM	von Willebrand factor, type A
HUW48_RS08655	ENOG4105DGW	oligopeptidase A
HUW48_RS08735	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HUW48_RS08770	ENOG4108NEV	two component transcriptional regulator, LytTR family
HUW48_RS08835	ENOG4107SYB	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HUW48_RS08880	ENOG410635A	Membrane
HUW48_RS08895	ENOG4107RGD	Major Facilitator superfamily
HUW48_RS08925	ENOG4108YYH	Nadph-dependent fmn reductase
HUW48_RS08950	ENOG4108YYC	ycei family
HUW48_RS08965	ENOG4105T58	Dithiol-disulfide isomerase
HUW48_RS08980	ENOG41076HS	cation diffusion facilitator family transporter
HUW48_RS09020	ENOG410612X	Catalyzes the decarbonylation of fatty aldehydes to alkanes. Requires the presence of ferredoxin, ferredoxin reductase and NADPH for in vitro decarbonylase activity (By similarity). Involved in the biosynthesis of alkanes, mainly heptadecane and pentadecane
HUW48_RS09035	ENOG410836F	Transposase
HUW48_RS09050	ENOG4105C4R	Atp-dependent dna helicase
HUW48_RS09095	ENOG4105FFC	UPF0187 protein
HUW48_RS09105	ENOG4105BZ1	(ABC) transporter
HUW48_RS09125	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
HUW48_RS09185	ENOG4105EMN	RNA polymerase sigma factor
HUW48_RS09195	ENOG4105EUJ	GTP cyclohydrolase i
HUW48_RS09200	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
HUW48_RS09230	ENOG41090HT	Inherit from COG: transposase
HUW48_RS09235	ENOG4105C6Z	Gluconate
HUW48_RS09250	ENOG4105E0C	molybdate abc transporter
HUW48_RS09255	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
HUW48_RS09275	ENOG4108IJF	Heavy metal efflux pump, CzcA
HUW48_RS09280	ENOG4108IJF	Heavy metal efflux pump, CzcA
HUW48_RS09295	ENOG4105C59	p-type ATPase
HUW48_RS09305	ENOG4105EUB	pirin domain protein
HUW48_RS09340	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HUW48_RS09345	ENOG4105F4R	Transcriptional regulator mode
HUW48_RS09375	ENOG4107RJ1	sodium solute
HUW48_RS09420	ENOG4105ETE	Transcriptional regulator (LacI family
HUW48_RS09430	ENOG4105EPC	oxidoreductase
HUW48_RS09440	ENOG4107RGD	Major Facilitator superfamily
HUW48_RS09445	ENOG4105CHR	reductase
HUW48_RS09475	ENOG4105DZG	Dehydrogenase
HUW48_RS09500	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
HUW48_RS09510	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
HUW48_RS09525	ENOG4105DZG	Dehydrogenase
HUW48_RS09550	ENOG4105CXK	mandelate racemase muconate lactonizing
HUW48_RS09560	ENOG4105C27	TonB-dependent Receptor Plug
HUW48_RS09570	ENOG4105CXK	mandelate racemase muconate lactonizing
HUW48_RS09575	ENOG4105ETE	Transcriptional regulator (LacI family
HUW48_RS09580	ENOG4105EI3	2-dehydro-3-deoxygalactonokinase EC 2.7.1.58
HUW48_RS09600	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HUW48_RS09615	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HUW48_RS09620	ENOG4105DUX	Transporter
HUW48_RS09630	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HUW48_RS09635	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HUW48_RS09655	ENOG4107WT5	transcriptional regulator (NifA
HUW48_RS09660	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HUW48_RS09675	ENOG4105EGD	dinuclear metal center protein, YbgI family
HUW48_RS09680	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HUW48_RS09710	ENOG4107RBB	ABC transporter, permease
HUW48_RS09730	ENOG4105DKW	ABC transporter
HUW48_RS09740	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HUW48_RS09745	ENOG4105E0M	Sulfatase
HUW48_RS09760	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HUW48_RS09770	ENOG4105MSB	protein, conserved in bacteria
HUW48_RS09790	ENOG4105C8T	Leucyl-tRNA synthetase
HUW48_RS09800	ENOG4105DYC	esterase
HUW48_RS09805	ENOG4108ZIP	spheroidene monooxygenase
HUW48_RS09815	ENOG4108ZYK	Acyl carrier protein phosphodiesterase
HUW48_RS09820	ENOG4108YZY	peptidylprolyl cis-trans isomerase
HUW48_RS09850	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HUW48_RS09855	ENOG4106UW1	Major Facilitator superfamily
HUW48_RS09860	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HUW48_RS09865	ENOG4105BZU	Histidine kinase
HUW48_RS09895	ENOG4108VYJ	response regulator receiver protein
HUW48_RS09900	ENOG4105BZU	Histidine kinase
HUW48_RS09935	ENOG4105CYN	Serine protein kinase
HUW48_RS09945	ENOG4105ED1	spovr family
HUW48_RS09970	ENOG4105BZU	Histidine kinase
HUW48_RS10045	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HUW48_RS10050	ENOG4107QR9	Iron-sulfur cluster binding protein
HUW48_RS10055	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
HUW48_RS10065	ENOG4105W3H	MtN3 and saliva related transmembrane protein
HUW48_RS10095	ENOG4108MX5	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity)
HUW48_RS10105	ENOG4105ES5	Histidine kinase
HUW48_RS10110	ENOG4105VEQ	Cold shock protein
HUW48_RS10145	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HUW48_RS10165	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HUW48_RS10175	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
HUW48_RS10180	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HUW48_RS10200	ENOG4105C5H	ABC transporter
HUW48_RS10240	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
HUW48_RS10265	ENOG4105DVT	helicase
HUW48_RS10275	ENOG4105C02	permease
HUW48_RS10280	ENOG4105DNX	Dna topoisomerase iv (Subunit b)
HUW48_RS10285	ENOG4105DF5	DNA topoisomerase IV, subunit A
HUW48_RS10305	ENOG4105C22	threonyL-tRNA synthetase
HUW48_RS10310	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HUW48_RS10315	ENOG4105VJV	50s ribosomal protein L35
HUW48_RS10320	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HUW48_RS10340	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HUW48_RS10345	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HUW48_RS10350	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HUW48_RS10355	ENOG4105C3M	thioredoxin reductase
HUW48_RS10360	ENOG4105DR5	peptidase
HUW48_RS10370	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HUW48_RS10375	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HUW48_RS10385	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HUW48_RS10415	ENOG4109015	Biopolymer transport protein exbD tolR
HUW48_RS10430	ENOG4107UGT	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HUW48_RS10435	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
HUW48_RS10440	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HUW48_RS10455	ENOG4105DJV	ribulose-phosphate 3-epimerase
HUW48_RS10470	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HUW48_RS10480	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HUW48_RS10485	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HUW48_RS10490	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HUW48_RS10495	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HUW48_RS10500	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HUW48_RS10505	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HUW48_RS10520	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HUW48_RS10560	ENOG4108HRK	Histidine kinase
HUW48_RS10565	ENOG4105DY9	regulatoR
HUW48_RS10575	ENOG41086K9	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HUW48_RS10580	ENOG4107SVC	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HUW48_RS10595	ENOG4105CN1	protease
HUW48_RS10605	ENOG4108Z9Z	response to DNA damage stimulus
HUW48_RS10615	ENOG4105D44	asparaginase
HUW48_RS10635	ENOG4108IAB	Phoh family
HUW48_RS10655	ENOG4107SRH	Nad-dependent epimerase dehydratase
HUW48_RS10660	ENOG4105CBX	hi0933 family
HUW48_RS10670	ENOG4105CIB	oxidoreductase Domain protein
HUW48_RS10685	ENOG41080TC	multidrug resistance protein
HUW48_RS10690	ENOG4105C1J	atp-dependent rna helicase
HUW48_RS10700	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
HUW48_RS10710	ENOG4107RMM	double-strand break repair protein Addb
HUW48_RS10715	ENOG4109066	lysm domain bon superfamily protein
HUW48_RS10725	ENOG4105CGY	Dna recombination protein
HUW48_RS10750	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HUW48_RS10760	ENOG41082T9	Membrane
HUW48_RS10770	ENOG4107PHP	CheC --inhibitor of MCP methylation
HUW48_RS10775	ENOG4105CBS	Chea signal transduction histidine kinase
HUW48_RS10775	ENOG4105CBS	Chea signal transduction histidine kinase
HUW48_RS10780	ENOG4107YTP	response regulator receiver protein
HUW48_RS10785	ENOG4108V3W	Chemotaxis protein, CheW
HUW48_RS10790	ENOG4105C8Q	Methyl-accepting chemotaxis
HUW48_RS10795	ENOG4107QJE	Chromosome Partitioning Protein
HUW48_RS10800	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HUW48_RS10810	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HUW48_RS10815	ENOG4105DTQ	mandelate racemase muconate lactonizing
HUW48_RS10820	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
HUW48_RS10825	ENOG41067HS	methyltransferase
HUW48_RS10835	ENOG4107QI1	Mate efflux family protein
HUW48_RS10850	ENOG4108Z7R	Chaperone CsaA
HUW48_RS10875	ENOG4105DFA	alanine racemase domain protein
HUW48_RS10880	ENOG4105M08	Membrane
HUW48_RS10890	ENOG4107SID	ATP-dependent exodnase (exonuclease v)
HUW48_RS10900	ENOG4105M6F	mutator MutT protein
HUW48_RS10910	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HUW48_RS10920	ENOG4107RIV	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HUW48_RS10965	ENOG4105C3G	gtp-binding protein
HUW48_RS10980	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HUW48_RS11000	ENOG4105C5H	ABC transporter
HUW48_RS11025	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HUW48_RS11045	ENOG4105CVJ	phosphoglycerate mutase
HUW48_RS11050	ENOG4105KA0	thioesterase Superfamily protein
HUW48_RS11060	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
HUW48_RS11075	ENOG4108IPT	Naphthoate synthase
HUW48_RS11090	ENOG4105CHR	reductase
HUW48_RS11100	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HUW48_RS11115	ENOG4105EZX	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity)
HUW48_RS11125	ENOG4105C27	TonB-dependent Receptor Plug
HUW48_RS11135	ENOG4105ETE	Transcriptional regulator (LacI family
HUW48_RS11155	ENOG4105C9F	isomerase
HUW48_RS11265	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
HUW48_RS11280	ENOG4105M10	Involved in the anomeric conversion of L-rhamnose (By similarity)
HUW48_RS11295	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
HUW48_RS11345	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
HUW48_RS11355	ENOG4105CKK	Glycosyl transferase, family 2
HUW48_RS11405	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HUW48_RS11425	ENOG4105CDH	Citrulline--aspartate ligase
HUW48_RS11430	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HUW48_RS11435	ENOG4105C8Y	Acetylornithine aminotransferase
HUW48_RS11445	ENOG4107T6X	nag kinase
HUW48_RS11450	ENOG4105II7	pyrroline-5-carboxylate reductase
HUW48_RS11460	ENOG4105CH7	arginosuccinase
HUW48_RS11485	ENOG4105EPC	oxidoreductase
HUW48_RS11500	ENOG4106A4F	Removes the N-terminal methionine from nascent proteins (By similarity)
HUW48_RS11505	ENOG4105D9R	oxidoreductase
HUW48_RS11525	ENOG4105CPQ	Dehydrogenase
HUW48_RS11535	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HUW48_RS11560	ENOG4105CN1	protease
HUW48_RS11585	ENOG4105FQP	Beta-lactamase
HUW48_RS11640	ENOG4105C59	p-type ATPase
HUW48_RS11665	ENOG4105F5H	Glycosyl Hydrolase Family 88
HUW48_RS11680	ENOG4105E08	Glycoside hydrolase, family 9
HUW48_RS11710	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
HUW48_RS11715	ENOG4107RSM	transcriptional regulator
HUW48_RS11725	ENOG4105CPC	Aldo Keto reductase
HUW48_RS11730	ENOG4107S5I	aldo keto reductase
HUW48_RS11740	ENOG4107R6F	Alpha Beta Hydrolase Fold protein
HUW48_RS11745	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HUW48_RS11770	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HUW48_RS11775	ENOG4105CU9	asparagine synthetase A
HUW48_RS11790	ENOG4108UJU	UPF0301 protein
HUW48_RS11805	ENOG4108Z03	MAF-like protein
HUW48_RS11810	ENOG4105CPC	Aldo Keto reductase
HUW48_RS11825	ENOG4105HJ8	Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity)
HUW48_RS11875	ENOG4105C72	UPF0176 protein
HUW48_RS11885	ENOG41080XP	Cbs domain
HUW48_RS11890	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HUW48_RS11895	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HUW48_RS11905	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HUW48_RS11910	ENOG4105GKE	subunit e
HUW48_RS11915	ENOG4107QIZ	NADH dehydrogenase
HUW48_RS11920	ENOG4108IEH	NADH dehydrogenase subunit g
HUW48_RS11925	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HUW48_RS11930	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HUW48_RS11935	ENOG4107UFS	subunit j
HUW48_RS11940	ENOG41080EA	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HUW48_RS11945	ENOG4105D65	subunit l
HUW48_RS11950	ENOG4105C8S	subunit m
HUW48_RS11955	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HUW48_RS11970	ENOG4105DZ0	fad dependent oxidoreductase
HUW48_RS12010	ENOG4105CPP	Dehydrogenase, E1 component
HUW48_RS12015	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HUW48_RS12055	ENOG4108R6K	riboflavin synthase, subunit alpha
HUW48_RS12065	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HUW48_RS12070	ENOG4108S4H	thioesterase Superfamily protein
HUW48_RS12080	ENOG4108IFH	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUW48_RS12085	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HUW48_RS12090	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HUW48_RS12105	ENOG4105C79	DNA protecting protein DprA
HUW48_RS12115	ENOG4105DR4	Methyltransferase
HUW48_RS12150	ENOG4107TZ2	Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity)
HUW48_RS12210	ENOG4105C27	TonB-dependent Receptor Plug
HUW48_RS12225	ENOG4108HRK	Histidine kinase
HUW48_RS12230	ENOG4108NEV	two component transcriptional regulator, LytTR family
HUW48_RS12245	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUW48_RS12260	ENOG4107TPS	domain protein
HUW48_RS12265	ENOG41087NI	Sulfite exporter TauE/SafE
HUW48_RS12285	ENOG4105DZG	Dehydrogenase
HUW48_RS12420	ENOG4105W5Q	DNA repair protein (RadC
HUW48_RS12445	ENOG4105C27	TonB-dependent Receptor Plug
HUW48_RS12465	ENOG4107RBB	ABC transporter, permease
HUW48_RS12495	ENOG4108VAC	response regulator
HUW48_RS12500	ENOG4108HRK	Histidine kinase
HUW48_RS12505	ENOG4108C33	Resolvase
HUW48_RS12525	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HUW48_RS12530	ENOG4105C8F	Beta-lactamase domain protein
HUW48_RS12565	ENOG41088PD	hydrolase
HUW48_RS12570	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUW48_RS12650	ENOG4105CQ7	ATP-dependent helicase
HUW48_RS12660	ENOG4105VTW	prevent-host-death family
HUW48_RS12715	ENOG4105BZU	Histidine kinase
HUW48_RS12740	ENOG4105D64	Mechanosensitive ion channel
HUW48_RS12745	ENOG4105CKW	Inner membrane protein yedI
HUW48_RS12760	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
HUW48_RS12770	ENOG4105D0M	Protease HtpX homolog
HUW48_RS12790	ENOG4105E0X	reductase
HUW48_RS12805	ENOG4107WCI	zn-dependent hydrolase of the beta-lactamase fold-like protein
HUW48_RS12855	ENOG410635A	Membrane
HUW48_RS12860	ENOG4105D3R	alkyl hydroperoxide reductase
HUW48_RS12875	ENOG4107YXA	Transcriptional regulator, BadM Rrf2 family
HUW48_RS12880	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HUW48_RS12885	ENOG4105CGH	5'-nucleotidase
HUW48_RS12915	ENOG4105CMN	Methylmalonyl-coA mutase
HUW48_RS12920	ENOG4105D5P	Methylmalonyl-coA mutase
HUW48_RS12935	ENOG4105KWG	Pfam:DUF1696
HUW48_RS12950	ENOG4108RCM	Nitroreductase
HUW48_RS12975	ENOG4105KRF	dihydroneopterin aldolase
HUW48_RS12990	ENOG4107YAK	holo-(acyl carrier protein) synthase 2
HUW48_RS13000	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HUW48_RS13010	ENOG4105UYK	outer membrane protein a
HUW48_RS13015	ENOG4107QJZ	Glycosyl transferase, family 2
HUW48_RS13020	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HUW48_RS13050	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HUW48_RS13055	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HUW48_RS13070	ENOG4105C3M	thioredoxin reductase
HUW48_RS13075	ENOG4105BZU	Histidine kinase
HUW48_RS13085	ENOG4108NQD	
HUW48_RS13100	ENOG4105BZU	Histidine kinase
HUW48_RS13105	ENOG4105BZU	Histidine kinase
HUW48_RS13125	ENOG4105DGW	oligopeptidase A
HUW48_RS13140	ENOG4105C9K	Endothelin-converting enzyme 1
HUW48_RS13150	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
HUW48_RS13155	ENOG4105BZS	acriflavin resistance protein
HUW48_RS13185	ENOG4105CBG	Sulfatase
HUW48_RS13225	ENOG4105D2H	Uronic isomerase
HUW48_RS13230	ENOG4107QZW	Altronate oxidoreductase
HUW48_RS13235	ENOG4107QP7	CoA-transferase subunit A
HUW48_RS13250	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
HUW48_RS13255	ENOG4105CUT	histidyl-tRNA synthetase
HUW48_RS13260	ENOG4105C84	Histidine ammonia-lyase
HUW48_RS13275	ENOG41080DW	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HUW48_RS13290	ENOG4105CPP	Dehydrogenase, E1 component
HUW48_RS13315	ENOG4108TJN	glycosyl transferase group 1
HUW48_RS13325	ENOG4108TJN	glycosyl transferase group 1
HUW48_RS13340	ENOG4105D2T	synthase
HUW48_RS13350	ENOG4105C7K	acetolactate synthase
HUW48_RS13370	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HUW48_RS13375	ENOG4105FAW	cDP-glucose 4,6-dehydratase
HUW48_RS13380	ENOG4105EJZ	Glucose-1-phosphate cytidylyltransferase
HUW48_RS13395	ENOG4107Y2X	deaminase
HUW48_RS13415	ENOG4105C5E	polysaccharide biosynthesis protein
HUW48_RS13425	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HUW48_RS13435	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HUW48_RS13455	ENOG4105D2T	synthase
HUW48_RS13495	ENOG4105CAK	Cell division ATP-binding protein ftsE
HUW48_RS13505	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HUW48_RS13520	ENOG4105VDW	Csbd family
HUW48_RS13525	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HUW48_RS13535	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HUW48_RS13555	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HUW48_RS13570	ENOG4105CJ1	ABC, transporter
HUW48_RS13645	ENOG4105MHT	Transcriptional regulator, ARSR family
HUW48_RS13695	ENOG4105DPW	Major facilitator superfamily MFS_1
HUW48_RS13710	ENOG4105BZU	Histidine kinase
HUW48_RS13715	ENOG4105NTD	Inherit from COG: Hydrolase
HUW48_RS13725	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HUW48_RS13745	ENOG4108UW5	maltose o-acetyltransferase
HUW48_RS13750	ENOG4105ENX	hydrolase
HUW48_RS13765	ENOG4105EMU	Dehydrogenase
HUW48_RS13785	ENOG4105EBR	Carboxylesterase
HUW48_RS13805	ENOG4105C6T	cysteine synthase
HUW48_RS13820	ENOG4105DQ4	alcohol dehydrogenase
HUW48_RS13825	ENOG4107XKX	isoquinoline 1-oxidoreductase, alpha subunit
HUW48_RS13830	ENOG4105DIP	Molybdopterin dehydrogenase FAD-binding
HUW48_RS13835	ENOG4105C7W	Xanthine dehydrogenase
HUW48_RS13855	ENOG4105TT1	Ragb susd domain-containing protein
HUW48_RS13925	ENOG4105C5I	Dehydrogenase
HUW48_RS13945	ENOG4105D05	Receptor
HUW48_RS13980	ENOG4105EXC	Acyl-transferase
HUW48_RS13995	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HUW48_RS14000	ENOG4105BZU	Histidine kinase
HUW48_RS14045	ENOG4105BZU	Histidine kinase
HUW48_RS14050	ENOG4105WH1	Two component transcriptional regulator luxr family
HUW48_RS14065	ENOG4105QE3	oxidoreductase
HUW48_RS14080	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HUW48_RS14095	ENOG4105CPC	Aldo Keto reductase
HUW48_RS14145	ENOG41077A9	carbonic anhydrase
HUW48_RS14160	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HUW48_RS14170	ENOG4105CMG	Carbohydrate kinase
HUW48_RS14175	ENOG4105C93	Xylose Isomerase
HUW48_RS14185	ENOG4107TJ9	Cytochrome
HUW48_RS14190	ENOG4108KF3	Electron transport protein SCO1 SenC
HUW48_RS14220	ENOG4105CA0	peroxidase
HUW48_RS14230	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HUW48_RS14245	ENOG4105CTX	dehydratase
HUW48_RS14330	ENOG4105CNM	Receptor
HUW48_RS14345	ENOG4105ES5	Histidine kinase
HUW48_RS14365	ENOG4105CEP	NADH dehydrogenase
HUW48_RS14380	ENOG4105BZU	Histidine kinase
HUW48_RS14390	ENOG4105HSS	phospholipase C
HUW48_RS14395	ENOG4108HRK	Histidine kinase
HUW48_RS14410	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HUW48_RS14425	ENOG4105BZU	Histidine kinase
HUW48_RS14435	ENOG4105QD0	anti-sigma regulatory factor serine threonine protein kinase
HUW48_RS14440	ENOG4105FUA	antagonist
HUW48_RS14445	ENOG4107MMM	Anti-sigma-factor antagonist
HUW48_RS14485	ENOG4105CBZ	Short-chain dehydrogenase reductase Sdr
HUW48_RS14500	ENOG4108Q35	Adenylate
HUW48_RS14525	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
HUW48_RS14530	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HUW48_RS14545	ENOG4105D29	Helix-turn-helix type 11 domain protein
HUW48_RS14560	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HUW48_RS14570	ENOG4105CRS	phenylacetate-CoA oxygenase PaaG subunit
HUW48_RS14585	ENOG4108ZA2	phenylacetate-CoA oxygenase PaaJ subunit
HUW48_RS14615	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HUW48_RS14620	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
HUW48_RS14630	ENOG4107R0I	Cell wall formation (By similarity)
HUW48_RS14645	ENOG4105C98	muts2 protein
HUW48_RS14690	ENOG4108RH7	phosphoglycerate mutase
HUW48_RS14710	ENOG4108IAJ	Nad-dependent epimerase dehydratase
HUW48_RS14715	ENOG4105DQ4	alcohol dehydrogenase
HUW48_RS14720	ENOG4105CK5	oxidoreductase
HUW48_RS14725	ENOG4107STW	synthase
HUW48_RS14745	ENOG4108MIC	Mg-protoporphyrin IX methyl transferase
HUW48_RS14755	ENOG4105CPP	Dehydrogenase, E1 component
HUW48_RS14785	ENOG4105EFZ	amidohydrolase
HUW48_RS14790	ENOG4105EYW	Ion transport protein
HUW48_RS14795	ENOG4105DEU	major facilitator superfamily
HUW48_RS14820	ENOG4105E0Y	RtcB Protein
HUW48_RS14825	ENOG4105C0H	protease
HUW48_RS14845	ENOG4105VRT	cytoplasmic protein
HUW48_RS14865	ENOG4105C02	permease
HUW48_RS14885	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUW48_RS14895	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
HUW48_RS14900	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HUW48_RS14905	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HUW48_RS14910	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
HUW48_RS14915	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HUW48_RS14920	ENOG4107RI6	Anthranilate phosphoribosyltransferase
HUW48_RS14925	ENOG4105DDQ	anthranilate synthase
HUW48_RS14935	ENOG4105CRQ	synthase (Component I)
HUW48_RS14945	ENOG4108IUK	alpha amylase, catalytic
HUW48_RS14985	ENOG4105ME7	Membrane
HUW48_RS15000	ENOG4105HHA	aminodeoxychorismate lyase
HUW48_RS15005	ENOG4105BZU	Histidine kinase
HUW48_RS15010	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HUW48_RS15030	ENOG4107QX3	carboxylase
HUW48_RS15035	ENOG4105CN9	Peptidase m42 family protein
HUW48_RS15040	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
HUW48_RS15045	ENOG4107TXC	Transcriptional regulator
HUW48_RS15055	ENOG4105D49	3-dehydroquinate synthase
HUW48_RS15100	ENOG4105CN1	protease
HUW48_RS15140	ENOG4108KHS	signal transduction Histidine kinase
HUW48_RS15145	ENOG4108NEV	two component transcriptional regulator, LytTR family
HUW48_RS15160	ENOG4105D3P	Mannan endo-1,4-beta-mannosidase
HUW48_RS15190	ENOG4105CDW	Resistance protein
HUW48_RS15200	ENOG4105DJB	Major Facilitator Superfamily
HUW48_RS15205	ENOG4105CHR	reductase
HUW48_RS15215	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HUW48_RS15275	ENOG4105D17	glycoside hydrolase, family 3 domain protein
HUW48_RS15290	ENOG4108RZE	Tetr family transcriptional regulator
HUW48_RS15320	ENOG4105C02	permease
HUW48_RS15350	ENOG4107QN2	dihydrolipoyl dehydrogenase
HUW48_RS15465	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HUW48_RS15490	ENOG4105BZW	Glycerate kinase
HUW48_RS15495	ENOG4105C5I	Dehydrogenase
HUW48_RS15505	ENOG4105DWT	malate dehydrogenase (quinone)
HUW48_RS15510	ENOG4105D29	Helix-turn-helix type 11 domain protein
HUW48_RS15530	ENOG4105K5X	acetyltransferase
HUW48_RS15560	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
HUW48_RS15565	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HUW48_RS15570	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HUW48_RS15575	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HUW48_RS15585	ENOG4105D5P	Methylmalonyl-coA mutase
HUW48_RS15595	ENOG41082J7	Rhodanese domain protein
HUW48_RS15610	ENOG4105CPF	Cell wall formation (By similarity)
HUW48_RS15615	ENOG4105BZA	Phosphoglycerate kinase
HUW48_RS15630	ENOG4108JA1	polyketide synthase
HUW48_RS15635	ENOG4105RHY	Pfam:UPF0157
HUW48_RS15650	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HUW48_RS15665	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HUW48_RS15680	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
HUW48_RS15690	ENOG4108RWI	nicotinamidase
HUW48_RS15705	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HUW48_RS15720	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HUW48_RS15730	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HUW48_RS15735	ENOG4108ZHJ	Organic hydroperoxide resistance protein
HUW48_RS15745	ENOG4105CUB	amino acid
HUW48_RS15755	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HUW48_RS15760	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HUW48_RS15770	ENOG4105DFU	Cell wall formation (By similarity)
HUW48_RS15775	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HUW48_RS15780	ENOG4105CNI	cell division protein FtsW
HUW48_RS15785	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HUW48_RS15790	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HUW48_RS15795	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HUW48_RS15800	ENOG4105CJN	penicillin-binding protein
HUW48_RS15810	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HUW48_RS15815	ENOG4107YM1	mraZ protein
HUW48_RS15830	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HUW48_RS15855	ENOG4105EMN	RNA polymerase sigma factor
HUW48_RS15875	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
HUW48_RS15885	ENOG4105C9A	Phoh family
HUW48_RS15905	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HUW48_RS15925	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HUW48_RS15950	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HUW48_RS15955	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HUW48_RS15965	ENOG4105C1G	acyl-Coa dehydrogenase
HUW48_RS15985	ENOG4105CAT	Cytidine monophosphate kinase
HUW48_RS16005	ENOG4108VPC	n-acetylmuramoyl-l-alanine amidase
HUW48_RS16015	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HUW48_RS16030	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HUW48_RS16035	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HUW48_RS16040	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HUW48_RS16050	ENOG4107R33	ppx gppa phosphatase
HUW48_RS16055	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HUW48_RS16060	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HUW48_RS16065	ENOG4105BZU	Histidine kinase
HUW48_RS16070	ENOG4105EN6	Membrane
HUW48_RS16085	ENOG4108HKT	sucrose-6-phosphate hydrolase
HUW48_RS16090	ENOG4108HKT	sucrose-6-phosphate hydrolase
HUW48_RS16095	ENOG4108HKT	sucrose-6-phosphate hydrolase
HUW48_RS16130	ENOG4105D3P	Mannan endo-1,4-beta-mannosidase
HUW48_RS16145	ENOG4105WH1	Two component transcriptional regulator luxr family
HUW48_RS16155	ENOG4105DT9	hydrolase family 43
HUW48_RS16160	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HUW48_RS16180	ENOG4105F27	Major Facilitator
HUW48_RS16190	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HUW48_RS16195	ENOG4105DSG	hydrolase family 43
HUW48_RS16210	ENOG4105C6Z	Gluconate
HUW48_RS16215	ENOG4105C01	Dihydroxy-acid dehydratase
HUW48_RS16220	ENOG4108UHU	Aldolase
HUW48_RS16255	ENOG4108ZG0	Ompa motb domain protein
HUW48_RS16340	ENOG4105FFC	UPF0187 protein
HUW48_RS16370	ENOG4105BZ1	(ABC) transporter
HUW48_RS16375	ENOG4107R6T	Involved in the transcription termination process (By similarity)
HUW48_RS16385	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HUW48_RS16395	ENOG4105VIE	preprotein translocase, subunit YajC
HUW48_RS16405	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HUW48_RS16410	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
HUW48_RS16415	ENOG4105D0H	Alpha-glucuronidase (EC 3.2.1.139)
HUW48_RS16420	ENOG4105D9F	endo-1,4-beta-xylanase (EC 3.2.1.8)
HUW48_RS16500	ENOG4105C7N	Xanthine uracil vitamin C permease
HUW48_RS16520	ENOG4107SMB	hydrolase Family 5
HUW48_RS16565	ENOG4105C10	Electron transfer flavoprotein
HUW48_RS16570	ENOG4105BZJ	Electron transfer flavoprotein
HUW48_RS16600	ENOG4105GR3	Histidine kinase
HUW48_RS16605	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HUW48_RS16615	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
HUW48_RS16620	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HUW48_RS16675	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HUW48_RS16680	ENOG4105Q2H	domain protein
HUW48_RS16700	ENOG4105ICD	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
HUW48_RS16710	ENOG4105KI2	Urea amidohydrolase subunit beta
HUW48_RS16755	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HUW48_RS16760	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HUW48_RS16770	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HUW48_RS16775	ENOG4108YZG	isomerase
HUW48_RS16785	ENOG4105CHR	reductase
HUW48_RS16795	ENOG4105C2C	drug resistance transporter, Bcr CflA
HUW48_RS16800	ENOG4105CPC	Aldo Keto reductase
HUW48_RS16815	ENOG4105DCG	PHP domain protein
HUW48_RS16835	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
HUW48_RS16840	ENOG4105CXT	aspartate transcarbamylase
HUW48_RS16845	ENOG4105KT5	UmuD protein
HUW48_RS16850	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HUW48_RS16860	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HUW48_RS16880	ENOG4105E0X	reductase
HUW48_RS16885	ENOG4105CI3	gtp-binding protein typa
HUW48_RS16895	ENOG4105VCH	membrane
HUW48_RS16905	ENOG4105XRQ	Xanthine dehydrogenase accessory factor
HUW48_RS16920	ENOG4108ZIE	5 nucleotidase deoxy cytosolic type C
HUW48_RS16970	ENOG4105DY9	regulatoR
HUW48_RS16975	ENOG4106UX7	integral membrane protein
HUW48_RS16980	ENOG4105D8V	Glucose sorbosone dehydrogenase
HUW48_RS16995	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HUW48_RS17015	ENOG4105C27	TonB-dependent Receptor Plug
HUW48_RS17040	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUW48_RS17045	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HUW48_RS17065	ENOG4107SBB	4-alpha-glucanotransferase (EC 2.4.1.25)
HUW48_RS17085	ENOG4105BZU	Histidine kinase
HUW48_RS17090	ENOG4105CI2	imidazolone-5-propionate hydrolase
HUW48_RS17095	ENOG4105I82	acetyl xylan esterase
HUW48_RS17100	ENOG4105BZU	Histidine kinase
HUW48_RS17170	ENOG4105C27	TonB-dependent Receptor Plug
HUW48_RS17180	ENOG4108R99	pseudouridine synthase
HUW48_RS17190	ENOG4107RQD	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity)
HUW48_RS17200	ENOG4105CKY	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity)
HUW48_RS17205	ENOG4108UQ1	hydrolase, family 25
HUW48_RS17230	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
HUW48_RS17275	ENOG4105NXH	GreA GreB family elongation factor
HUW48_RS17290	ENOG4105DU1	integral membrane protein, terc
HUW48_RS17300	ENOG4105NXH	GreA GreB family elongation factor
HUW48_RS17305	ENOG4105NXH	GreA GreB family elongation factor
HUW48_RS17315	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HUW48_RS17350	ENOG4105EJU	HAD-superfamily hydrolase subfamily IA variant 3
HUW48_RS17360	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HUW48_RS17385	ENOG4105ECP	epimerase
HUW48_RS17410	ENOG4105D3R	alkyl hydroperoxide reductase
HUW48_RS17440	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HUW48_RS17465	ENOG4107QV8	Conserved hypothetical protein 698
HUW48_RS17515	ENOG4105KVH	Transcriptional regulator
HUW48_RS17565	ENOG4107SSZ	Phosphatase
HUW48_RS17580	ENOG4105CDU	Replicative dna helicase
HUW48_RS17585	ENOG4105DFU	Cell wall formation (By similarity)
HUW48_RS17600	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
HUW48_RS17610	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUW48_RS17650	ENOG4105CTQ	phosphohexokinase
HUW48_RS17655	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HUW48_RS17665	ENOG4105BZU	Histidine kinase
HUW48_RS17670	ENOG4108MGY	Histidine kinase
HUW48_RS17680	ENOG4108H5C	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HUW48_RS17730	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
HUW48_RS17750	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HUW48_RS17785	ENOG4105VEQ	Cold shock protein
HUW48_RS17820	ENOG4108JUA	Transcriptional regulator
HUW48_RS17830	ENOG4108C33	Resolvase
HUW48_RS17870	ENOG4108XW0	May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF
HUW48_RS17925	ENOG4105C28	cystathionine
HUW48_RS17930	ENOG4108IDZ	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HUW48_RS17970	ENOG4105CQC	Prephenate dehydratase
HUW48_RS17975	ENOG4105CHM	Aminotransferase
HUW48_RS17980	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HUW48_RS18005	ENOG4105CCN	Peptidase M56
HUW48_RS18020	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HUW48_RS18040	ENOG4105CQB	FAD linked oxidase domain protein
HUW48_RS18075	ENOG4105EU0	Major facilitator Superfamily
HUW48_RS18090	ENOG4108YYS	metal-dependent hydrolase (By similarity)
HUW48_RS18110	ENOG410904N	short-chain dehydrogenase reductase
HUW48_RS18115	ENOG4107RJ1	sodium solute
HUW48_RS18135	ENOG4105E8R	UPF0173 metal-dependent hydrolase
HUW48_RS18145	ENOG4107RJ1	sodium solute
HUW48_RS18150	ENOG4105BZ1	(ABC) transporter
HUW48_RS18160	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HUW48_RS18170	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HUW48_RS18175	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HUW48_RS18185	ENOG4105DZP	Membrane-associated zinc metalloprotease
HUW48_RS18190	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HUW48_RS18200	ENOG4108Z9K	Osmotically inducible protein
HUW48_RS18265	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HUW48_RS18270	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HUW48_RS18285	ENOG4105EEI	dihydropteroate synthase
HUW48_RS18290	ENOG4105C8B	TIGR00159 family
HUW48_RS18305	ENOG4108NEV	two component transcriptional regulator, LytTR family
HUW48_RS18310	ENOG4107TDE	lipolytic protein G-D-S-L family
HUW48_RS18355	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HUW48_RS18360	ENOG4105C6K	Malic enzyme
HUW48_RS18385	ENOG4107SET	aldo keto reductase
HUW48_RS18390	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HUW48_RS18410	ENOG4107R95	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HUW48_RS18495	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HUW48_RS18605	ENOG41082BM	Transcriptional regulator, arsr family
HUW48_RS18650	ENOG4105F9U	Dehydrogenase
HUW48_RS18700	ENOG4105F0N	pyrophosphate phospho-hydrolase
HUW48_RS18755	ENOG4105VNH	ABC transporter solute-binding protein
HUW48_RS18770	ENOG4105BZG	amino acid carrier protein
HUW48_RS18785	ENOG4105W2Z	cytochrome C, class I
HUW48_RS18795	ENOG4105C26	Dehydrogenase
HUW48_RS18805	ENOG4108I0Z	Aconitate hydratase
HUW48_RS18835	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HUW48_RS18880	ENOG4105C5A	transporter
HUW48_RS18885	ENOG4105E7W	lamb ycsf family protein
HUW48_RS18895	ENOG4105P4J	Allophanate hydrolase, subunit 1
HUW48_RS18915	ENOG4107SET	aldo keto reductase
HUW48_RS18925	ENOG4105DZR	Type I site-specific deoxyribonuclease
HUW48_RS18950	ENOG4105BZU	Histidine kinase
HUW48_RS18960	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
HUW48_RS18965	ENOG4105K6S	Short-chain dehydrogenase reductase Sdr
HUW48_RS19020	ENOG4105CHR	reductase
HUW48_RS19035	ENOG4105C19	ABC transporter
HUW48_RS19055	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HUW48_RS19085	ENOG4105EMN	RNA polymerase sigma factor
HUW48_RS19135	ENOG4105QNR	S1 RNA binding domain protein
HUW48_RS19155	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HUW48_RS19160	ENOG4105E2R	ROK family
HUW48_RS19180	ENOG4105KHA	Glyoxalase Bleomycin resistance protein (Dioxygenase
HUW48_RS19190	ENOG4108IJ8	ABC transporter
HUW48_RS19195	ENOG4105E90	ABC transporter
HUW48_RS19200	ENOG4105DY9	regulatoR
HUW48_RS19205	ENOG4108HRK	Histidine kinase
HUW48_RS19215	ENOG4108YYC	ycei family
HUW48_RS19230	ENOG4105K8N	protein family UPF0079, ATPase
HUW48_RS19235	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HUW48_RS19240	ENOG4105DCI	Phosphohydrolase
HUW48_RS19250	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HUW48_RS19255	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HUW48_RS19260	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HUW48_RS19265	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
HUW48_RS19285	ENOG4105CEV	competence damage-inducible protein
HUW48_RS19290	ENOG4105C7S	Dehydrogenase
HUW48_RS19310	ENOG4105C19	ABC transporter
HUW48_RS19320	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HUW48_RS19330	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HUW48_RS19335	ENOG4105BZU	Histidine kinase
HUW48_RS19340	ENOG4105DNP	FAD linked oxidase domain protein
HUW48_RS19355	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HUW48_RS19370	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HUW48_RS19380	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
HUW48_RS19385	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
HUW48_RS19405	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HUW48_RS19410	ENOG4105C72	UPF0176 protein
HUW48_RS19430	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
HUW48_RS19460	ENOG4105C1J	atp-dependent rna helicase
HUW48_RS19475	ENOG4105CNN	ABC, transporter
HUW48_RS19480	ENOG4105C2J	ABC transporter
HUW48_RS19500	ENOG4105CEY	Amp-dependent synthetase and ligase
HUW48_RS19505	ENOG410853W	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HUW48_RS19515	ENOG4105C19	ABC transporter
HUW48_RS19585	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HUW48_RS19605	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HUW48_RS19610	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HUW48_RS19615	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HUW48_RS19620	ENOG4108URH	decarboxylase
HUW48_RS19635	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HUW48_RS19650	ENOG4108UKI	Enoyl-CoA hydratase
HUW48_RS19660	ENOG4105C5S	asparaginyl-tRNA synthetase
HUW48_RS19665	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HUW48_RS19680	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HUW48_RS19685	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HUW48_RS19690	ENOG4105C4K	Nad synthetase
HUW48_RS19695	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HUW48_RS19700	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HUW48_RS19705	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HUW48_RS19720	ENOG4105RA3	Binds directly to 16S ribosomal RNA (By similarity)
HUW48_RS19725	ENOG4105DNZ	Alpha Beta Hydrolase
HUW48_RS19740	ENOG4105EP6	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
HUW48_RS19750	ENOG4107URF	beta-phospho-glucomutase
HUW48_RS19785	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HUW48_RS19835	ENOG4108TFU	terminase (Small subunit)
HUW48_RS19895	ENOG4108RAV	Conserved protein
HUW48_RS19955	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HUW48_RS19970	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HUW48_RS19980	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HUW48_RS19985	ENOG4105E39	Enoyl-CoA hydratase
HUW48_RS19995	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HUW48_RS20025	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HUW48_RS20030	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HUW48_RS20040	ENOG4105C6K	Malic enzyme
HUW48_RS20045	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HUW48_RS20055	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HUW48_RS20065	ENOG4105C5I	Dehydrogenase
HUW48_RS20070	ENOG4105DSJ	YicC domain protein
HUW48_RS20075	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
HUW48_RS20095	ENOG4105C5X	domain protein
HUW48_RS20100	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
HUW48_RS20125	ENOG4105E0K	tonB-dependent siderophore receptor
HUW48_RS20130	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HUW48_RS20145	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HUW48_RS20175	ENOG4105CPP	Dehydrogenase, E1 component
HUW48_RS20190	ENOG4108FN7	Aldo keto reductase
HUW48_RS20215	ENOG4105C3M	thioredoxin reductase
HUW48_RS20235	ENOG4105C5H	ABC transporter
HUW48_RS20250	ENOG4105FDK	ABC transporter
HUW48_RS20305	ENOG4105CHR	reductase
HUW48_RS20310	ENOG4105C26	Dehydrogenase
HUW48_RS20315	ENOG4105C0H	protease
HUW48_RS20320	ENOG4105VN1	Heat shock protein
HUW48_RS20340	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
HUW48_RS20345	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HUW48_RS20350	ENOG4107R33	ppx gppa phosphatase
HUW48_RS20355	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HUW48_RS20360	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HUW48_RS20400	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HUW48_RS20405	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HUW48_RS20410	ENOG4108ZT0	50S ribosomal protein l17
HUW48_RS20415	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HUW48_RS20420	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HUW48_RS20425	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HUW48_RS20430	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUW48_RS20435	ENOG410864M	50S ribosomal protein L36
HUW48_RS20440	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HUW48_RS20445	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HUW48_RS20450	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HUW48_RS20455	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HUW48_RS20460	ENOG41084HK	50S ribosomal protein L30
HUW48_RS20465	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HUW48_RS20470	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HUW48_RS20475	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HUW48_RS20480	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HUW48_RS20485	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HUW48_RS20490	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUW48_RS20495	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HUW48_RS20500	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HUW48_RS20505	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HUW48_RS20510	ENOG4108628	50s ribosomal protein l29
HUW48_RS20515	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HUW48_RS20520	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HUW48_RS20525	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HUW48_RS20530	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HUW48_RS20535	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUW48_RS20540	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HUW48_RS20545	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HUW48_RS20550	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HUW48_RS20555	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HUW48_RS20560	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HUW48_RS20565	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HUW48_RS20570	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HUW48_RS20585	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HUW48_RS20590	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HUW48_RS20595	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HUW48_RS20600	ENOG4107VNI	ribosomal protein l10
HUW48_RS20605	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HUW48_RS20610	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HUW48_RS20650	ENOG4105CD8	aminopeptidase N
HUW48_RS20660	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HUW48_RS20665	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HUW48_RS20670	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HUW48_RS20695	ENOG4105D2N	Aldolase
HUW48_RS20705	ENOG4105BZU	Histidine kinase
HUW48_RS20710	ENOG4105CIY	formyltetrahydrofolate deformylase
HUW48_RS20720	ENOG4106N3A	copper homeostasis protein cutc
HUW48_RS20745	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HUW48_RS20750	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HUW48_RS20760	ENOG4105EMN	RNA polymerase sigma factor
HUW48_RS20775	ENOG4106WTF	Glycosyl transferase, family 2
HUW48_RS20780	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
HUW48_RS20790	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HUW48_RS20805	ENOG4105E18	UPF0276 protein
HUW48_RS20810	ENOG4108VX5	3-methyladenine DNA glycosylase
HUW48_RS20820	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HUW48_RS20835	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HUW48_RS20840	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HUW48_RS20845	ENOG4105C8S	subunit m
HUW48_RS20855	ENOG41082X4	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HUW48_RS20870	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HUW48_RS20875	ENOG4106032	Glutathionylspermidine synthase
HUW48_RS20885	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HUW48_RS20895	ENOG4105C5H	ABC transporter
HUW48_RS20905	ENOG4105CDY	transcriptional regulatory protein
HUW48_RS20910	ENOG4105C1J	atp-dependent rna helicase
HUW48_RS20915	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
HUW48_RS20920	ENOG4108V06	Glutathione peroxidase
HUW48_RS20925	ENOG4105C75	arginyL-tRNA synthetase
HUW48_RS20940	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
HUW48_RS20945	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
HUW48_RS20950	ENOG4105DU1	integral membrane protein, terc
HUW48_RS20970	ENOG4106KXD	ATP-dependent carboxylate-amine ligase (By similarity)
HUW48_RS20985	ENOG4106CKV	Pap2 superfamily protein
HUW48_RS20990	ENOG410841Q	phosphoesterase PA-phosphatase related protein
HUW48_RS21000	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
HUW48_RS21005	ENOG4107QTF	adenylosuccinate lyase
HUW48_RS21020	ENOG4105CKK	Glycosyl transferase, family 2
HUW48_RS21035	ENOG4105CD3	dihydroorotase
HUW48_RS21075	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HUW48_RS21080	ENOG41082AN	stage II sporulation protein
HUW48_RS21090	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HUW48_RS21100	ENOG4107V87	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity)
HUW48_RS21105	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HUW48_RS21110	ENOG4107SQC	5-methylcytosine-specific restriction enzyme subunit McrC
HUW48_RS21115	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
HUW48_RS21120	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HUW48_RS21125	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HUW48_RS21135	ENOG4105EHG	Permease protein
HUW48_RS21140	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
HUW48_RS21145	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
HUW48_RS21150	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HUW48_RS21170	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HUW48_RS21230	ENOG4105D01	(LipO)protein
HUW48_RS21235	ENOG4108UMI	ABC transporter, permease
HUW48_RS21255	ENOG4108RVA	ribokinase
HUW48_RS21275	ENOG4105VEQ	Cold shock protein
HUW48_RS21290	ENOG4105MA4	psp1 domain protein
HUW48_RS21320	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HUW48_RS21340	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
HUW48_RS21350	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HUW48_RS21375	ENOG4107R6F	Alpha Beta Hydrolase Fold protein
HUW48_RS21395	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HUW48_RS21420	ENOG4108IAJ	Nad-dependent epimerase dehydratase
HUW48_RS21425	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HUW48_RS21430	ENOG4105CAQ	asparagine synthetase
HUW48_RS21435	ENOG4108QBX	(LipO)protein
HUW48_RS21440	ENOG4108KPZ	tonB-dependent Receptor
HUW48_RS21470	ENOG41061MV	Arylsulfatase
HUW48_RS21475	ENOG4105CBG	Sulfatase
HUW48_RS21495	ENOG4106NZI	LysR family Transcriptional regulator
HUW48_RS21520	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HUW48_RS21525	ENOG4108YYC	ycei family
HUW48_RS21545	ENOG4105DTQ	mandelate racemase muconate lactonizing
HUW48_RS21560	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HUW48_RS21580	ENOG4105ED2	Beta-lactamase
HUW48_RS21595	ENOG4105CEV	competence damage-inducible protein
HUW48_RS21615	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
HUW48_RS21625	ENOG4108PBA	serine threonine protein kinase
HUW48_RS21630	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HUW48_RS21635	ENOG4108RMU	ferritin dps family protein
HUW48_RS21685	ENOG4105CY3	ABC transporter, permease
HUW48_RS21690	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HUW48_RS21700	ENOG4108JYZ	YitT family
HUW48_RS21705	ENOG4105C3F	Signal peptidase i
HUW48_RS21725	ENOG4107KJX	Transcriptional regulator
HUW48_RS21760	ENOG4105DGU	Histone deacetylase
HUW48_RS21780	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HUW48_RS21800	ENOG4105R8C	Transcriptional regulator
HUW48_RS21805	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HUW48_RS21810	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HUW48_RS21840	ENOG4105CDU	Replicative dna helicase
HUW48_RS21865	ENOG4107SCJ	type I restriction enzyme EcoKI subunit R
HUW48_RS21870	ENOG4105CVR	type I restriction-modification system
HUW48_RS21875	ENOG4107XZC	Restriction modification system DNA (Specificity
HUW48_RS21890	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
HUW48_RS21990	ENOG4105WH1	Two component transcriptional regulator luxr family
HUW48_RS21995	ENOG4105BZU	Histidine kinase
HUW48_RS22035	ENOG4105C0B	DNA polymerase III (alpha subunit)
HUW48_RS22040	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HUW48_RS22045	ENOG4108IMY	Transcriptional regulator
HUW48_RS22080	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
HUW48_RS22085	ENOG4108XHQ	(2Fe-2S)-binding domain protein
HUW48_RS22105	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HUW48_RS22130	ENOG4105EPC	oxidoreductase
HUW48_RS22140	ENOG4105D7N	magnesium and cobalt transport protein CorA
HUW48_RS22145	ENOG4107QHQ	amino acid
HUW48_RS22160	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
HUW48_RS22175	ENOG4105CEY	Amp-dependent synthetase and ligase
HUW48_RS22190	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUW48_RS22295	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HUW48_RS22300	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
HUW48_RS22305	ENOG4105EE5	Membrane protein terC
HUW48_RS22310	ENOG4108VPT	UPF0234 protein
HUW48_RS22330	ENOG4108JA2	transcriptioN-repair coupling factor
HUW48_RS22340	ENOG4105CHM	Aminotransferase
HUW48_RS22365	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
HUW48_RS22370	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
HUW48_RS22375	ENOG4107T8Q	Glycosyl transferase (Group 1
HUW48_RS22380	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HUW48_RS22435	ENOG4105BZU	Histidine kinase
HUW48_RS22440	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HUW48_RS22455	ENOG4107VMU	Membrane
HUW48_RS22515	ENOG4107QHQ	amino acid
HUW48_RS22535	ENOG4108JQC	penicillin-binding protein 1A
HUW48_RS22555	ENOG4105EPC	oxidoreductase
HUW48_RS22585	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HUW48_RS22590	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HUW48_RS22605	ENOG4105CN1	protease
HUW48_RS22650	ENOG4108UJV	acyl-CoA thioesterase i
HUW48_RS22655	ENOG4108I0Y	(ABC) transporter
HUW48_RS22665	ENOG4105BZU	Histidine kinase
HUW48_RS22675	ENOG4107XM9	(LipO)protein
HUW48_RS22680	ENOG4105C7B	Threonine dehydratase
HUW48_RS22685	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HUW48_RS22690	ENOG4108ZP8	Acetolactate synthase small subunit
HUW48_RS22695	ENOG4105C7K	acetolactate synthase
HUW48_RS22700	ENOG4105C01	Dihydroxy-acid dehydratase
HUW48_RS22705	ENOG4105CFH	Aspartokinase
HUW48_RS22710	ENOG4107RDY	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HUW48_RS22715	ENOG4105D98	threonine synthase
HUW48_RS22720	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HUW48_RS22725	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HUW48_RS22730	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HUW48_RS22735	ENOG4107UQD	Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity)
HUW48_RS22740	ENOG4105BZU	Histidine kinase
HUW48_RS22755	ENOG4108FN7	Aldo keto reductase
HUW48_RS22760	ENOG4105D8V	Glucose sorbosone dehydrogenase
HUW48_RS22765	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HUW48_RS22780	ENOG4107S2Z	UPF0761 membrane protein
HUW48_RS22795	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HUW48_RS22815	ENOG4105KIR	Thiol-disulfide oxidoreductase dcc
HUW48_RS22865	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
HUW48_RS22870	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HUW48_RS22880	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HUW48_RS22885	ENOG4107R39	(ABC) transporter
HUW48_RS22890	ENOG4107QN2	dihydrolipoyl dehydrogenase
HUW48_RS22900	ENOG4105C7S	Dehydrogenase
HUW48_RS22905	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HUW48_RS22920	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HUW48_RS22925	ENOG4108QG2	Membrane
HUW48_RS22950	ENOG4108IJ0	Aspartate ammonia-lyase
HUW48_RS23020	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUW48_RS23025	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HUW48_RS23030	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HUW48_RS23035	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HUW48_RS23040	ENOG4108HFV	
HUW48_RS23045	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HUW48_RS23100	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HUW48_RS23160	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HUW48_RS23170	ENOG4105WH1	Two component transcriptional regulator luxr family
HUW48_RS23175	ENOG41090A1	ferritin
HUW48_RS23235	ENOG4105D0M	Protease HtpX homolog
HUW48_RS23285	ENOG41076HS	cation diffusion facilitator family transporter
HUW48_RS23295	ENOG4105C3R	Methionine synthase
HUW48_RS23300	ENOG4105SYT	Methylenetetrahydrofolate reductase
HUW48_RS23335	ENOG4105QJH	Domain of unknown function (DUF718)
HUW48_RS23340	ENOG4107S8A	protein TIM barrel
HUW48_RS23345	ENOG4105CPQ	Dehydrogenase
HUW48_RS23350	ENOG4105CPC	Aldo Keto reductase
HUW48_RS23360	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HUW48_RS23370	ENOG4105BZ1	(ABC) transporter
HUW48_RS23385	ENOG4105C0P	Mg chelatase subunit ChlI
HUW48_RS23400	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HUW48_RS23405	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HUW48_RS23415	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HUW48_RS23425	ENOG4105CP7	Triose-phosphate isomerase
HUW48_RS23475	ENOG4105CKK	Glycosyl transferase, family 2
HUW48_RS23480	ENOG410902V	Modulates RecA activity (By similarity)
HUW48_RS23495	ENOG4105K6H	D-cysteine desulfhydrase
HUW48_RS23530	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HUW48_RS23560	ENOG4105VN1	Heat shock protein
HUW48_RS23565	ENOG4105VN1	Heat shock protein
HUW48_RS23585	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HUW48_RS23595	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HUW48_RS23600	ENOG4105K46	50S ribosomal protein l27
HUW48_RS23610	ENOG4105CP2	von willebrand factor, type a
HUW48_RS23660	ENOG4105E6M	Sulphatase-modifying factor protein
HUW48_RS23680	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HUW48_RS23685	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HUW48_RS23750	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
HUW48_RS23775	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HUW48_RS23780	ENOG4107PMW	Arabinan endo-1,5-alpha-L-arabinosidase
HUW48_RS23800	ENOG4105CZZ	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
HUW48_RS23845	ENOG4105C02	permease
HUW48_RS23860	ENOG4108NEV	two component transcriptional regulator, LytTR family
HUW48_RS23865	ENOG4108HRK	Histidine kinase
HUW48_RS23880	ENOG4105BZU	Histidine kinase
HUW48_RS23885	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HUW48_RS23900	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HUW48_RS23925	ENOG4105KME	endoribonuclease L-psp
HUW48_RS23930	ENOG4105CD3	dihydroorotase
HUW48_RS23975	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HUW48_RS23985	ENOG4108VHC	Short-chain dehydrogenase reductase Sdr
HUW48_RS23995	ENOG4108IG5	Transcriptional regulator
HUW48_RS24000	ENOG4105F1N	DNA alkylation repair
HUW48_RS24075	ENOG4105NAE	bifunctional deaminase-reductase domain protein
HUW48_RS24135	ENOG4105BZ1	(ABC) transporter
HUW48_RS24140	ENOG4105EBR	Carboxylesterase
HUW48_RS24150	ENOG4105BZP	glycoside hydrolase 15-related
HUW48_RS24200	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
HUW48_RS24205	ENOG4105KZX	Pterin carbinolamine dehydratase
HUW48_RS24210	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HUW48_RS24225	ENOG4105ECY	inositol monophosphatase
HUW48_RS24245	ENOG4105D8X	mechanosensitive ion channel
HUW48_RS24260	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HUW48_RS24270	ENOG4107RGD	Major Facilitator superfamily
HUW48_RS24285	ENOG4105C9Q	fumarate hydratase class II
HUW48_RS24290	ENOG4107R6F	Alpha Beta Hydrolase Fold protein
HUW48_RS24300	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HUW48_RS24305	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HUW48_RS24310	ENOG4108YZG	isomerase
HUW48_RS24320	ENOG4105H4N	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HUW48_RS24330	ENOG4105D60	lipoprotein releasing system transmembrane protein
HUW48_RS24335	ENOG4105C0D	helicase
HUW48_RS24360	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HUW48_RS24370	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
HUW48_RS24385	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HUW48_RS24405	ENOG4105C27	TonB-dependent Receptor Plug
HUW48_RS24415	ENOG4105C28	cystathionine
HUW48_RS24420	ENOG410635A	Membrane
HUW48_RS24425	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
HUW48_RS24445	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HUW48_RS24455	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HUW48_RS24475	ENOG4108D32	Methyltransferase
HUW48_RS24495	ENOG4105K6T	rare lipoprotein A
HUW48_RS24515	ENOG4107V8H	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HUW48_RS24540	ENOG4108IUZ	ABC transporter
HUW48_RS24565	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HUW48_RS24575	ENOG4105KME	endoribonuclease L-psp
HUW48_RS24585	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HUW48_RS24595	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HUW48_RS24600	ENOG4107RWD	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HUW48_RS24605	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
HUW48_RS24615	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HUW48_RS24625	ENOG4105C1G	acyl-Coa dehydrogenase
HUW48_RS24635	ENOG4108RCS	geranylgeranylglyceryl phosphate synthase
HUW48_RS24650	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HUW48_RS24655	ENOG4105CH6	catalase
HUW48_RS24710	ENOG4107QJT	sodium dicarboxylate symporter
HUW48_RS24740	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HUW48_RS24745	ENOG41088CQ	domain protein
HUW48_RS24810	ENOG4105WH1	Two component transcriptional regulator luxr family
HUW48_RS24835	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HUW48_RS24845	ENOG4105DUX	Transporter
HUW48_RS24855	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HUW48_RS24860	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
HUW48_RS24885	ENOG4105CQ7	ATP-dependent helicase
HUW48_RS24890	ENOG4107QM2	Aldo Keto reductase
HUW48_RS24895	ENOG4105FE9	pseudouridine synthase
HUW48_RS24945	ENOG4105E6M	Sulphatase-modifying factor protein
HUW48_RS24950	ENOG4105MJ2	Competence protein
HUW48_RS24965	ENOG4105CGK	Exodeoxyribonuclease III
HUW48_RS24980	ENOG41080AX	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HUW48_RS24985	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HUW48_RS25010	ENOG4105CJ3	phosphate transporter
HUW48_RS25015	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
HUW48_RS25025	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HUW48_RS25030	ENOG4107T7F	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HUW48_RS25035	ENOG4108JQ6	ABC transporter
HUW48_RS25040	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HUW48_RS25045	ENOG4105EAH	synthase
HUW48_RS25080	ENOG4108Z9Z	response to DNA damage stimulus
HUW48_RS25085	ENOG4105CK7	Sodium proline symporter
HUW48_RS25090	ENOG4105CDY	transcriptional regulatory protein
HUW48_RS25095	ENOG4107T5V	SNARE associated Golgi
HUW48_RS25110	ENOG4105EVE	HAD-superfamily hydrolase subfamily IA variant 3
HUW48_RS25125	ENOG4107VAM	peptidase, m28
HUW48_RS25145	ENOG4105CHM	Aminotransferase
HUW48_RS25150	ENOG4105D17	glycoside hydrolase, family 3 domain protein
HUW48_RS25175	ENOG4105BZU	Histidine kinase
HUW48_RS25180	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HUW48_RS25195	ENOG4105BZM	domain protein
HUW48_RS25210	ENOG4105CSH	Transporter
HUW48_RS25235	ENOG4105EP9	oxidoreductase
HUW48_RS25250	ENOG4105F1J	Homogentisate 1,2-dioxygenase
HUW48_RS25260	ENOG4105CAQ	asparagine synthetase
HUW48_RS25265	ENOG4105CSM	endonuclease III
HUW48_RS25275	ENOG4108AEY	RNA polymerase sigma factor
HUW48_RS25285	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HUW48_RS25325	ENOG4108IFG	nitrite reductase, (NAD(P)H)
HUW48_RS25360	ENOG4108S4H	thioesterase Superfamily protein
HUW48_RS25370	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HUW48_RS25375	ENOG4107R0V	Pyruvate dehydrogenase
HUW48_RS25385	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HUW48_RS25400	ENOG4105SCY	DNAK suppressor
HUW48_RS25405	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HUW48_RS25410	ENOG4105FE9	pseudouridine synthase
HUW48_RS25415	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
HUW48_RS25435	ENOG4105C37	(CBS) domain
HUW48_RS25440	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
HUW48_RS25450	ENOG4105CMG	Carbohydrate kinase
HUW48_RS25455	ENOG4105EAA	nucleoside
HUW48_RS25480	ENOG4105EMN	RNA polymerase sigma factor
HUW48_RS25490	ENOG4107XU6	Glycosyl transferase (Group 1
HUW48_RS25500	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HUW48_RS25510	ENOG4105KME	endoribonuclease L-psp
HUW48_RS25540	ENOG4105C27	TonB-dependent Receptor Plug
HUW48_RS25555	ENOG4105CS2	ec 3.2.1.21
HUW48_RS25560	ENOG4105EIK	Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity)
HUW48_RS25630	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
HUW48_RS25665	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HUW48_RS25670	ENOG4107RBB	ABC transporter, permease
HUW48_RS25690	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HUW48_RS25705	ENOG4107RBB	ABC transporter, permease
HUW48_RS25710	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HUW48_RS25725	ENOG4105CAY	ferredoxin--nadp reductase
HUW48_RS25735	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HUW48_RS25740	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
HUW48_RS25800	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
HUW48_RS25815	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HUW48_RS25820	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HUW48_RS25825	ENOG4105EB3	Histidine kinase
HUW48_RS25850	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
HUW48_RS25855	ENOG4108ZGC	gaf domain protein
HUW48_RS25860	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HUW48_RS25865	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HUW48_RS25870	ENOG4105J5G	Transferase hexapeptide repeat containing protein
HUW48_RS25875	ENOG4107QQG	Dehydrogenase
HUW48_RS25880	ENOG4105CMR	udp-glucose 4-epimerase
HUW48_RS25885	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HUW48_RS25890	ENOG4108IAJ	Nad-dependent epimerase dehydratase
HUW48_RS25895	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
HUW48_RS25900	ENOG4105CI2	imidazolone-5-propionate hydrolase
HUW48_RS25910	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HUW48_RS25930	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HUW48_RS25945	ENOG4107QJZ	Glycosyl transferase, family 2
HUW48_RS25955	ENOG4105BZ1	(ABC) transporter
HUW48_RS25990	ENOG4105CE1	Ferrous iron transport protein b
HUW48_RS26015	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
HUW48_RS26060	ENOG4105C1J	atp-dependent rna helicase
HUW48_RS26065	ENOG4105CD3	dihydroorotase
HUW48_RS26095	ENOG41061CK	Antibiotic biosynthesis monooxygenase
HUW48_RS26110	ENOG4105VG0	50S ribosomal protein l34
HUW48_RS26115	ENOG4105WG6	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HUW48_RS26120	ENOG4105CN1	protease
HUW48_RS26165	ENOG4105CHR	reductase
HUW48_RS26180	ENOG4105DJB	Major Facilitator Superfamily
HUW48_RS26185	ENOG4105C27	TonB-dependent Receptor Plug
HUW48_RS26255	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HUW48_RS26265	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HUW48_RS26270	ENOG41083X6	30S ribosomal protein S21
HUW48_RS26275	ENOG4105C1G	acyl-Coa dehydrogenase
HUW48_RS26305	ENOG41061P3	phosphosulfolactate synthase
HUW48_RS26310	ENOG4105DQR	SNARE associated Golgi
HUW48_RS26315	ENOG4105E2X	shikimate dehydrogenase
HUW48_RS26350	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HUW48_RS26380	ENOG4107RSM	transcriptional regulator
HUW48_RS26385	ENOG41082K6	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HUW48_RS26390	ENOG4105PGM	cation diffusion facilitator family transporter
HUW48_RS26410	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HUW48_RS26415	ENOG4105CK5	oxidoreductase
HUW48_RS26430	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HUW48_RS26475	ENOG4108ZJ4	polysaccharide deacetylase
HUW48_RS26480	ENOG4107R8N	Glycosyl transferase, family 2
HUW48_RS26485	ENOG4105F8V	Hydrolase, tatD family
HUW48_RS26490	ENOG4105HDK	L-asparaginase
HUW48_RS26510	ENOG4107QYX	exodeoxyribonuclease v alpha
HUW48_RS26515	ENOG4107QMH	DNA methylase
HUW48_RS26555	ENOG4108YZS	Had-superfamily hydrolase, subfamily ia, variant 1
HUW48_RS26585	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HUW48_RS26595	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HUW48_RS26600	ENOG41062D9	Histidine kinase
HUW48_RS26620	ENOG4108JQB	penicillin-binding protein 1C
HUW48_RS26630	ENOG4105C5H	ABC transporter
HUW48_RS26640	ENOG4107ZXU	DSBA oxidoreductase