locus-tag	class	description
HUW48_RS00020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUW48_RS00050	COG1970	mechanosensitive ion channel activity
HUW48_RS00120	COG1278	Cold shock
HUW48_RS00145	COG2226	methyltransferase
HUW48_RS00155	COG0798	PFAM Bile acid sodium symporter
HUW48_RS00165	COG1742	UPF0060 membrane protein
HUW48_RS00170	COG2217	Heavy metal translocating P-type atpase
HUW48_RS00215	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUW48_RS00280	COG2217	Heavy metal translocating P-type atpase
HUW48_RS00295	COG2217	Heavy metal translocating P-type atpase
HUW48_RS00300	COG1396	sequence-specific DNA binding
HUW48_RS00325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUW48_RS00355	COG1196	nuclear chromosome segregation
HUW48_RS00355	COG0741	lytic transglycosylase activity
HUW48_RS00355	COG0739	heme binding
HUW48_RS00460	COG4227	nucleotidyltransferase activity
HUW48_RS00465	COG1192	Involved in chromosome partitioning
HUW48_RS00505	COG0643	Histidine kinase
HUW48_RS00505	COG2198	Histidine kinase
HUW48_RS00505	COG0784	Response regulator, receiver
HUW48_RS00510	COG5002	protein histidine kinase activity
HUW48_RS00520	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS00525	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUW48_RS00560	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUW48_RS00615	COG1295	ribonuclease BN
HUW48_RS00680	COG2207	Transcriptional regulator
HUW48_RS00680	COG1917	Cupin 2, conserved barrel domain protein
HUW48_RS00700	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS00715	COG4191	Histidine kinase
HUW48_RS00720	COG0784	Response regulator, receiver
HUW48_RS00725	COG0784	Response regulator, receiver
HUW48_RS00725	COG2198	Histidine kinase
HUW48_RS00725	COG2205	protein histidine kinase activity
HUW48_RS00730	COG0745	RESPONSE REGULATOR receiver
HUW48_RS00735	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUW48_RS00760	COG2217	Heavy metal translocating P-type atpase
HUW48_RS00795	COG3278	Belongs to the heme-copper respiratory oxidase family
HUW48_RS00805	COG2010	Cytochrome c
HUW48_RS00835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUW48_RS00865	COG4245	von Willebrand factor, type A
HUW48_RS00890	COG2084	Dehydrogenase
HUW48_RS00915	COG4977	sequence-specific DNA binding
HUW48_RS00940	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW48_RS00945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HUW48_RS00955	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW48_RS00980	COG1725	Transcriptional regulator
HUW48_RS00995	COG2814	Major facilitator Superfamily
HUW48_RS01005	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS01015	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS01030	COG1012	belongs to the aldehyde dehydrogenase family
HUW48_RS01050	COG0662	Cupin 2, conserved barrel domain protein
HUW48_RS01065	COG0745	RESPONSE REGULATOR receiver
HUW48_RS01065	COG3292	Two component regulator propeller
HUW48_RS01065	COG2205	protein histidine kinase activity
HUW48_RS01075	COG0577	efflux transmembrane transporter activity
HUW48_RS01080	COG0577	efflux transmembrane transporter activity
HUW48_RS01085	COG0577	efflux transmembrane transporter activity
HUW48_RS01090	COG0577	efflux transmembrane transporter activity
HUW48_RS01100	COG0577	efflux transmembrane transporter activity
HUW48_RS01120	COG2197	response regulator
HUW48_RS01135	COG1733	regulation of RNA biosynthetic process
HUW48_RS01150	COG0577	efflux transmembrane transporter activity
HUW48_RS01155	COG0577	efflux transmembrane transporter activity
HUW48_RS01160	COG0577	efflux transmembrane transporter activity
HUW48_RS01160	COG1136	(ABC) transporter
HUW48_RS01180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUW48_RS01185	COG0577	efflux transmembrane transporter activity
HUW48_RS01190	COG0577	efflux transmembrane transporter activity
HUW48_RS01200	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HUW48_RS01205	COG3387	PFAM Glycoside hydrolase 15-related
HUW48_RS01220	COG4771	TonB-dependent receptor
HUW48_RS01225	COG0561	phosphatase activity
HUW48_RS01235	COG3291	Pkd domain containing protein
HUW48_RS01255	COG0745	RESPONSE REGULATOR receiver
HUW48_RS01255	COG3292	Two component regulator propeller
HUW48_RS01255	COG2205	protein histidine kinase activity
HUW48_RS01280	COG1902	pentaerythritol trinitrate reductase activity
HUW48_RS01285	COG0667	Aldo Keto reductase
HUW48_RS01290	COG0300	oxidoreductase activity
HUW48_RS01315	COG0702	epimerase
HUW48_RS01330	COG1999	signal sequence binding
HUW48_RS01345	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUW48_RS01350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUW48_RS01355	COG3940	Belongs to the glycosyl hydrolase 43 family
HUW48_RS01360	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW48_RS01365	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HUW48_RS01370	COG4654	Cytochrome c, class I
HUW48_RS01380	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUW48_RS01385	COG1085	galactose-1-phosphate uridylyltransferase
HUW48_RS01390	COG0673	inositol 2-dehydrogenase activity
HUW48_RS01395	COG0442	prolyl-tRNA aminoacylation
HUW48_RS01430	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS01450	COG4864	UPF0365 protein
HUW48_RS01465	COG2223	nitrite transmembrane transporter activity
HUW48_RS01475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUW48_RS01475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUW48_RS01515	COG1704	LemA family
HUW48_RS01535	COG2852	Protein conserved in bacteria
HUW48_RS01560	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUW48_RS01565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUW48_RS01575	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUW48_RS01580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUW48_RS01590	COG0335	large ribosomal subunit rRNA binding
HUW48_RS01595	COG0336	Belongs to the RNA methyltransferase TrmD family
HUW48_RS01600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUW48_RS01605	COG0228	four-way junction DNA binding
HUW48_RS01615	COG0463	Glycosyl transferase, family 2
HUW48_RS01620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW48_RS01635	COG0564	pseudouridine synthase activity
HUW48_RS01640	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUW48_RS01650	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUW48_RS01660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUW48_RS01670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUW48_RS01675	COG2095	MarC family integral membrane protein
HUW48_RS01680	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HUW48_RS01685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUW48_RS01715	COG0300	oxidoreductase activity
HUW48_RS01720	COG0300	oxidoreductase activity
HUW48_RS01730	COG0542	response to heat
HUW48_RS01735	COG1187	pseudouridine synthase activity
HUW48_RS01740	COG0443	Heat shock 70 kDa protein
HUW48_RS01745	COG4585	Histidine kinase
HUW48_RS01755	COG2197	response regulator
HUW48_RS01770	COG3851	Histidine kinase
HUW48_RS01820	COG1902	pentaerythritol trinitrate reductase activity
HUW48_RS01825	COG1515	deoxyribonuclease V activity
HUW48_RS01850	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HUW48_RS01850	COG0517	IMP dehydrogenase activity
HUW48_RS01870	COG2366	antibiotic biosynthetic process
HUW48_RS01925	COG0346	lactoylglutathione lyase activity
HUW48_RS01930	COG2353	YceI-like domain
HUW48_RS01940	COG1940	carbohydrate kinase activity
HUW48_RS01945	COG2133	pyrroloquinoline quinone binding
HUW48_RS01950	COG1309	transcriptional regulator
HUW48_RS01980	COG2814	Major facilitator Superfamily
HUW48_RS01985	COG1505	serine-type exopeptidase activity
HUW48_RS02020	COG0792	nuclease activity
HUW48_RS02025	COG0166	Belongs to the GPI family
HUW48_RS02030	COG0321	lipoyl(octanoyl) transferase activity
HUW48_RS02060	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW48_RS02080	COG1289	transmembrane transporter activity
HUW48_RS02085	COG0322	excinuclease ABC activity
HUW48_RS02110	COG0356	it plays a direct role in the translocation of protons across the membrane
HUW48_RS02115	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUW48_RS02120	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUW48_RS02125	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUW48_RS02130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUW48_RS02135	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUW48_RS02140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUW48_RS02155	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUW48_RS02155	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HUW48_RS02180	COG0431	NADPH-dependent FMN reductase
HUW48_RS02190	COG0488	(ABC) transporter
HUW48_RS02210	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HUW48_RS02220	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HUW48_RS02250	COG0006	proline dipeptidase activity
HUW48_RS02255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW48_RS02285	COG4993	Dehydrogenase
HUW48_RS02305	COG1446	asparaginase
HUW48_RS02325	COG0714	Associated with various cellular activities
HUW48_RS02335	COG4654	Cytochrome c, class I
HUW48_RS02360	COG2226	methyltransferase
HUW48_RS02400	COG1138	Cytochrome C-type biogenesis protein
HUW48_RS02405	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUW48_RS02410	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HUW48_RS02415	COG1278	Cold shock
HUW48_RS02430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUW48_RS02435	COG0138	bifunctional purine biosynthesis protein purh
HUW48_RS02440	COG1077	Cell shape determining protein MreB Mrl
HUW48_RS02455	COG0768	penicillin binding
HUW48_RS02460	COG0772	Belongs to the SEDS family
HUW48_RS02485	COG0673	inositol 2-dehydrogenase activity
HUW48_RS02495	COG0363	glucosamine-6-phosphate deaminase activity
HUW48_RS02560	COG4771	TonB-dependent receptor
HUW48_RS02580	COG0709	Synthesizes selenophosphate from selenide and ATP
HUW48_RS02585	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HUW48_RS02590	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HUW48_RS02605	COG0512	Glutamine amidotransferase of anthranilate synthase
HUW48_RS02625	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUW48_RS02640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUW48_RS02660	COG0564	pseudouridine synthase activity
HUW48_RS02670	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HUW48_RS02685	COG0848	biopolymer transport protein
HUW48_RS02700	COG3956	TIGRFAM MazG family protein
HUW48_RS02705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUW48_RS02710	COG1104	cysteine desulfurase activity
HUW48_RS02715	COG0009	L-threonylcarbamoyladenylate synthase
HUW48_RS02720	COG1611	Belongs to the LOG family
HUW48_RS02725	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HUW48_RS02730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUW48_RS02735	COG1160	GTP binding
HUW48_RS02755	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HUW48_RS02770	COG1022	Amp-dependent synthetase and ligase
HUW48_RS02780	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUW48_RS02780	COG1024	Enoyl-CoA hydratase
HUW48_RS02785	COG0183	Belongs to the thiolase family
HUW48_RS02795	COG1960	acyl-CoA dehydrogenase activity
HUW48_RS02805	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HUW48_RS02815	COG4535	Mg2 and Co2 transporter CorC
HUW48_RS02820	COG0629	single-stranded DNA binding
HUW48_RS02825	COG1194	a g-specific adenine glycosylase
HUW48_RS02830	COG0776	regulation of translation
HUW48_RS02840	COG1530	ribonuclease E activity
HUW48_RS02865	COG0113	porphobilinogen synthase activity
HUW48_RS02875	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HUW48_RS02880	COG2267	carboxylic ester hydrolase activity
HUW48_RS02890	COG0251	oxidation-reduction process
HUW48_RS02895	COG1921	L-seryl-tRNASec selenium transferase activity
HUW48_RS02925	COG1435	thymidine kinase activity
HUW48_RS02940	COG1381	Involved in DNA repair and RecF pathway recombination
HUW48_RS02950	COG0545	Peptidyl-prolyl cis-trans isomerase
HUW48_RS02955	COG0545	Peptidyl-prolyl cis-trans isomerase
HUW48_RS02960	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUW48_RS02965	COG0105	UTP biosynthetic process
HUW48_RS02980	COG5180	pathogenesis
HUW48_RS02980	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUW48_RS02985	COG0195	Participates in both transcription termination and antitermination
HUW48_RS03000	COG0215	cysteine-tRNA ligase activity
HUW48_RS03005	COG1619	proteins homologs of microcin C7 resistance protein MccF
HUW48_RS03015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUW48_RS03020	COG2873	o-acetylhomoserine
HUW48_RS03025	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HUW48_RS03035	COG0590	tRNA wobble adenosine to inosine editing
HUW48_RS03050	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUW48_RS03055	COG1522	sequence-specific DNA binding
HUW48_RS03090	COG2755	lipolytic protein G-D-S-L family
HUW48_RS03095	COG2755	lipolytic protein G-D-S-L family
HUW48_RS03105	COG1629	transport
HUW48_RS03110	COG0702	epimerase
HUW48_RS03115	COG0745	RESPONSE REGULATOR receiver
HUW48_RS03115	COG3292	Two component regulator propeller
HUW48_RS03115	COG2205	protein histidine kinase activity
HUW48_RS03115	COG3292	Two component regulator propeller
HUW48_RS03115	COG0745	RESPONSE REGULATOR receiver
HUW48_RS03115	COG2205	protein histidine kinase activity
HUW48_RS03120	COG4771	TonB-dependent receptor
HUW48_RS03135	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS03140	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HUW48_RS03145	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HUW48_RS03150	COG0246	Mannitol dehydrogenase
HUW48_RS03155	COG2721	sulfolactate sulfo-lyase activity
HUW48_RS03160	COG1904	glucuronate isomerase
HUW48_RS03165	COG2271	Major facilitator Superfamily
HUW48_RS03175	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HUW48_RS03185	COG2755	lipolytic protein G-D-S-L family
HUW48_RS03190	COG4677	pectinesterase activity
HUW48_RS03250	COG3263	regulation of cellular component size
HUW48_RS03275	COG2382	esterase
HUW48_RS03285	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW48_RS03290	COG1082	Xylose isomerase domain protein TIM barrel
HUW48_RS03315	COG0657	acetylesterase activity
HUW48_RS03315	COG2755	lipolytic protein G-D-S-L family
HUW48_RS03330	COG2382	esterase
HUW48_RS03335	COG2382	esterase
HUW48_RS03340	COG2382	esterase
HUW48_RS03340	COG3693	PFAM glycoside hydrolase, family 10
HUW48_RS03340	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW48_RS03345	COG3693	PFAM glycoside hydrolase, family 10
HUW48_RS03345	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW48_RS03345	COG2382	esterase
HUW48_RS03355	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HUW48_RS03365	COG2382	esterase
HUW48_RS03375	COG2272	Belongs to the type-B carboxylesterase lipase family
HUW48_RS03380	COG2851	Citrate transporter
HUW48_RS03410	COG3386	PFAM SMP-30 Gluconolaconase
HUW48_RS03450	COG2197	response regulator
HUW48_RS03455	COG4585	Histidine kinase
HUW48_RS03460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW48_RS03475	COG2223	nitrite transmembrane transporter activity
HUW48_RS03480	COG0243	molybdopterin cofactor binding
HUW48_RS03490	COG0303	'Molybdopterin
HUW48_RS03505	COG0746	molybdenum cofactor guanylyltransferase activity
HUW48_RS03505	COG0315	cyclic pyranopterin monophosphate synthase activity
HUW48_RS03515	COG0314	molybdopterin synthase activity
HUW48_RS03525	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUW48_RS03530	COG1007	ATP synthesis coupled electron transport
HUW48_RS03535	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_RS03545	COG0713	ATP synthesis coupled electron transport
HUW48_RS03550	COG0839	Belongs to the complex I subunit 6 family
HUW48_RS03555	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_RS03560	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUW48_RS03565	COG1034	ATP synthesis coupled electron transport
HUW48_RS03580	COG0649	NAD binding
HUW48_RS03585	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_RS03590	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_RS03595	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_RS03600	COG0657	acetylesterase activity
HUW48_RS03600	COG2755	lipolytic protein G-D-S-L family
HUW48_RS03605	COG1012	belongs to the aldehyde dehydrogenase family
HUW48_RS03610	COG1011	Hydrolase
HUW48_RS03625	COG0626	cystathionine gamma-synthase activity
HUW48_RS03635	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUW48_RS03650	COG0343	queuine tRNA-ribosyltransferase activity
HUW48_RS03655	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUW48_RS03665	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HUW48_RS03670	COG0254	rRNA binding
HUW48_RS03675	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUW48_RS03685	COG0470	DNA polymerase III
HUW48_RS03690	COG0181	hydroxymethylbilane synthase activity
HUW48_RS03715	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUW48_RS03720	COG1331	Highly conserved protein containing a thioredoxin domain
HUW48_RS03730	COG0359	binds to the 23S rRNA
HUW48_RS03735	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUW48_RS03740	COG0360	Binds together with S18 to 16S ribosomal RNA
HUW48_RS03750	COG0437	4 iron, 4 sulfur cluster binding
HUW48_RS03780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUW48_RS03790	COG0109	protoheme IX farnesyltransferase activity
HUW48_RS03795	COG1845	cytochrome c oxidase, subunit III
HUW48_RS03810	COG1999	signal sequence binding
HUW48_RS03815	COG2322	membrane
HUW48_RS03825	COG5000	phosphorelay sensor kinase activity
HUW48_RS03850	COG5001	Diguanylate cyclase
HUW48_RS03865	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HUW48_RS03870	COG3123	guanosine phosphorylase activity
HUW48_RS03885	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HUW48_RS03890	COG4654	Cytochrome c, class I
HUW48_RS03905	COG0612	Peptidase, M16
HUW48_RS03910	COG0438	transferase activity, transferring glycosyl groups
HUW48_RS03915	COG0006	proline dipeptidase activity
HUW48_RS03920	COG2885	chlorophyll binding
HUW48_RS03940	COG0419	ATPase involved in DNA repair
HUW48_RS03960	COG0584	glycerophosphoryl diester phosphodiesterase
HUW48_RS03965	COG1139	Iron-sulfur cluster binding protein
HUW48_RS03980	COG2234	aminopeptidase activity
HUW48_RS03985	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUW48_RS04000	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HUW48_RS04010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW48_RS04020	COG2201	protein-glutamate methylesterase activity
HUW48_RS04045	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW48_RS04050	COG0673	inositol 2-dehydrogenase activity
HUW48_RS04055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUW48_RS04075	COG3279	Response regulator of the LytR AlgR family
HUW48_RS04080	COG3275	phosphorelay sensor kinase activity
HUW48_RS04090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUW48_RS04100	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUW48_RS04105	COG0006	proline dipeptidase activity
HUW48_RS04115	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUW48_RS04125	COG0552	protein localization to endoplasmic reticulum
HUW48_RS04135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUW48_RS04140	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HUW48_RS04145	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUW48_RS04150	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUW48_RS04180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUW48_RS04185	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUW48_RS04210	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUW48_RS04220	COG0745	RESPONSE REGULATOR receiver
HUW48_RS04225	COG5002	protein histidine kinase activity
HUW48_RS04230	COG0564	pseudouridine synthase activity
HUW48_RS04240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUW48_RS04245	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUW48_RS04250	COG0052	Belongs to the universal ribosomal protein uS2 family
HUW48_RS04255	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUW48_RS04275	COG0714	Associated with various cellular activities
HUW48_RS04290	COG2172	sigma factor antagonist activity
HUW48_RS04305	COG0516	GMP reductase activity
HUW48_RS04305	COG0517	IMP dehydrogenase activity
HUW48_RS04320	COG1253	flavin adenine dinucleotide binding
HUW48_RS04330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUW48_RS04345	COG0357	Ribosomal RNA small subunit methyltransferase G
HUW48_RS04355	COG0667	Aldo Keto reductase
HUW48_RS04380	COG2003	Belongs to the UPF0758 family
HUW48_RS04390	COG0072	phenylalanine-tRNA ligase activity
HUW48_RS04390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW48_RS04405	COG1418	mRNA catabolic process
HUW48_RS04420	COG1609	Transcriptional regulator
HUW48_RS04425	COG4771	TonB-dependent receptor
HUW48_RS04430	COG0561	phosphatase activity
HUW48_RS04435	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HUW48_RS04440	COG0673	inositol 2-dehydrogenase activity
HUW48_RS04470	COG0010	Belongs to the arginase family
HUW48_RS04480	COG2267	carboxylic ester hydrolase activity
HUW48_RS04510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW48_RS04525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUW48_RS04535	COG0438	transferase activity, transferring glycosyl groups
HUW48_RS04545	COG0438	transferase activity, transferring glycosyl groups
HUW48_RS04555	COG1216	Glycosyl transferase, family 2
HUW48_RS04555	COG0463	Glycosyl transferase, family 2
HUW48_RS04605	COG0183	Belongs to the thiolase family
HUW48_RS04610	COG0101	tRNA pseudouridine synthase activity
HUW48_RS04615	COG1132	(ABC) transporter
HUW48_RS04625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUW48_RS04640	COG4771	TonB-dependent receptor
HUW48_RS04645	COG0702	epimerase
HUW48_RS04680	COG0673	inositol 2-dehydrogenase activity
HUW48_RS04715	COG0363	glucosamine-6-phosphate deaminase activity
HUW48_RS04725	COG2222	sugar isomerase
HUW48_RS04735	COG5652	VanZ like family
HUW48_RS04740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUW48_RS04755	COG0823	Involved in the tonB-independent uptake of proteins
HUW48_RS04755	COG4946	Tricorn protease homolog
HUW48_RS04755	COG1506	peptidase
HUW48_RS04760	COG1629	transport
HUW48_RS04765	COG0702	epimerase
HUW48_RS04780	COG1349	DNA-binding transcription factor activity
HUW48_RS04790	COG0363	glucosamine-6-phosphate deaminase activity
HUW48_RS04800	COG0420	3'-5' exonuclease activity
HUW48_RS04805	COG2201	protein-glutamate methylesterase activity
HUW48_RS04810	COG0039	L-malate dehydrogenase activity
HUW48_RS04815	COG0037	tRNA processing
HUW48_RS04855	COG0497	DNA recombination
HUW48_RS04860	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUW48_RS04865	COG0662	Cupin 2, conserved barrel domain protein
HUW48_RS04865	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUW48_RS04870	COG3237	CsbD-like
HUW48_RS04880	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUW48_RS04920	COG0492	ferredoxin-NADP+ reductase activity
HUW48_RS04945	COG3206	protein involved in exopolysaccharide biosynthesis
HUW48_RS04945	COG0489	protein tyrosine kinase activity
HUW48_RS04960	COG1215	transferase activity, transferring glycosyl groups
HUW48_RS05005	COG0110	maltose O-acetyltransferase activity
HUW48_RS05010	COG0463	Glycosyl transferase, family 2
HUW48_RS05025	COG0297	glycogen (starch) synthase activity
HUW48_RS05075	COG0463	Glycosyl transferase, family 2
HUW48_RS05075	COG1216	Glycosyl transferase, family 2
HUW48_RS05080	COG0726	polysaccharide deacetylase
HUW48_RS05085	COG1215	transferase activity, transferring glycosyl groups
HUW48_RS05090	COG1216	Glycosyl transferase, family 2
HUW48_RS05110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW48_RS05115	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HUW48_RS05120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW48_RS05125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUW48_RS05145	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW48_RS05150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUW48_RS05155	COG0673	inositol 2-dehydrogenase activity
HUW48_RS05175	COG1555	photosystem II stabilization
HUW48_RS05175	COG1596	polysaccharide export
HUW48_RS05190	COG0473	3-isopropylmalate dehydrogenase activity
HUW48_RS05200	COG3158	transport of potassium into the cell
HUW48_RS05210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUW48_RS05215	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HUW48_RS05225	COG1629	transport
HUW48_RS05225	COG4206	TonB-dependent receptor
HUW48_RS05240	COG4948	Mandelate Racemase Muconate Lactonizing
HUW48_RS05245	COG4948	Mandelate Racemase Muconate Lactonizing
HUW48_RS05260	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUW48_RS05260	COG0473	3-isopropylmalate dehydrogenase activity
HUW48_RS05270	COG4948	Mandelate Racemase Muconate Lactonizing
HUW48_RS05275	COG0180	Tryptophanyl-tRNA synthetase
HUW48_RS05285	COG1234	tRNA 3'-trailer cleavage
HUW48_RS05295	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUW48_RS05300	COG0019	diaminopimelate decarboxylase activity
HUW48_RS05305	COG0527	aspartate kinase activity
HUW48_RS05315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUW48_RS05325	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HUW48_RS05330	COG0156	8-amino-7-oxononanoate synthase activity
HUW48_RS05335	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HUW48_RS05340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUW48_RS05370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW48_RS05390	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS05405	COG2272	Belongs to the type-B carboxylesterase lipase family
HUW48_RS05465	COG0823	Involved in the tonB-independent uptake of proteins
HUW48_RS05530	COG0667	Aldo Keto reductase
HUW48_RS05550	COG0702	epimerase
HUW48_RS05555	COG4771	TonB-dependent receptor
HUW48_RS05560	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HUW48_RS05625	COG4771	TonB-dependent receptor
HUW48_RS05630	COG0702	epimerase
HUW48_RS05645	COG3254	rhamnose metabolic process
HUW48_RS05655	COG1063	alcohol dehydrogenase
HUW48_RS05695	COG1216	Glycosyl transferase, family 2
HUW48_RS05715	COG1216	Glycosyl transferase, family 2
HUW48_RS05735	COG0463	Glycosyl transferase, family 2
HUW48_RS05735	COG1216	Glycosyl transferase, family 2
HUW48_RS05765	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HUW48_RS05775	COG0563	adenylate kinase activity
HUW48_RS05780	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUW48_RS05785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUW48_RS05790	COG0484	heat shock protein binding
HUW48_RS05795	COG4152	abc transporter atp-binding protein
HUW48_RS05805	COG3781	membrane
HUW48_RS05810	COG0316	Belongs to the HesB IscA family
HUW48_RS05825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUW48_RS05840	COG0438	transferase activity, transferring glycosyl groups
HUW48_RS05845	COG1472	Belongs to the glycosyl hydrolase 3 family
HUW48_RS05850	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HUW48_RS05875	COG0175	sulfate reduction
HUW48_RS05880	COG0529	Catalyzes the synthesis of activated sulfate
HUW48_RS05890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUW48_RS05900	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HUW48_RS05910	COG0175	sulfate reduction
HUW48_RS05915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW48_RS05920	COG0697	spore germination
HUW48_RS05930	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HUW48_RS05940	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUW48_RS05945	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUW48_RS05965	COG0189	ligase activity
HUW48_RS05965	COG4067	protein conserved in archaea
HUW48_RS05970	COG0189	ligase activity
HUW48_RS05975	COG3608	succinylglutamate desuccinylase aspartoacylase
HUW48_RS05995	COG0702	epimerase
HUW48_RS06000	COG0596	Alpha beta hydrolase
HUW48_RS06015	COG3618	amidohydrolase
HUW48_RS06030	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUW48_RS06035	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS06045	COG0673	inositol 2-dehydrogenase activity
HUW48_RS06085	COG0823	Involved in the tonB-independent uptake of proteins
HUW48_RS06100	COG1090	epimerase
HUW48_RS06105	COG0302	gtp cyclohydrolase
HUW48_RS06115	COG3118	belongs to the thioredoxin family
HUW48_RS06145	COG1388	LysM domain
HUW48_RS06145	COG1705	Flagellar rod assembly protein muramidase FlgJ
HUW48_RS06165	COG1053	succinate dehydrogenase
HUW48_RS06180	COG4941	Belongs to the sigma-70 factor family
HUW48_RS06215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUW48_RS06255	COG0527	aspartate kinase activity
HUW48_RS06265	COG3386	PFAM SMP-30 Gluconolaconase
HUW48_RS06280	COG0673	inositol 2-dehydrogenase activity
HUW48_RS06300	COG2207	Transcriptional regulator
HUW48_RS06300	COG0662	Cupin 2, conserved barrel domain protein
HUW48_RS06325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUW48_RS06330	COG2885	chlorophyll binding
HUW48_RS06340	COG2181	nitrate reductase activity
HUW48_RS06340	COG0247	lactate metabolic process
HUW48_RS06345	COG2181	nitrate reductase activity
HUW48_RS06345	COG0247	lactate metabolic process
HUW48_RS06390	COG4191	Histidine kinase
HUW48_RS06400	COG4974	Belongs to the 'phage' integrase family
HUW48_RS06440	COG1215	transferase activity, transferring glycosyl groups
HUW48_RS06445	COG0110	maltose O-acetyltransferase activity
HUW48_RS06455	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUW48_RS06455	COG2755	lipolytic protein G-D-S-L family
HUW48_RS06465	COG0463	Glycosyl transferase, family 2
HUW48_RS06465	COG1216	Glycosyl transferase, family 2
HUW48_RS06485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUW48_RS06490	COG0745	RESPONSE REGULATOR receiver
HUW48_RS06495	COG2198	Histidine kinase
HUW48_RS06495	COG5002	protein histidine kinase activity
HUW48_RS06495	COG0784	Response regulator, receiver
HUW48_RS06500	COG1215	transferase activity, transferring glycosyl groups
HUW48_RS06535	COG0668	transmembrane transport
HUW48_RS06540	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HUW48_RS06555	COG2314	TM2 domain
HUW48_RS06560	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUW48_RS06580	COG0531	amino acid
HUW48_RS06590	COG1266	CAAX protease self-immunity
HUW48_RS06595	COG4589	Belongs to the CDS family
HUW48_RS06600	COG0793	Belongs to the peptidase S41A family
HUW48_RS06605	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUW48_RS06615	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUW48_RS06620	COG0612	Peptidase, M16
HUW48_RS06625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUW48_RS06650	COG0799	negative regulation of ribosome biogenesis
HUW48_RS06655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUW48_RS06660	COG1556	Lactate utilization protein
HUW48_RS06705	COG0154	amidase activity
HUW48_RS06735	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HUW48_RS06755	COG2272	Belongs to the type-B carboxylesterase lipase family
HUW48_RS06785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUW48_RS06850	COG1597	lipid kinase activity
HUW48_RS06905	COG3590	peptidase
HUW48_RS06910	COG3876	Protein conserved in bacteria
HUW48_RS06915	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HUW48_RS06920	COG0616	signal peptide processing
HUW48_RS06930	COG0067	glutamate synthase
HUW48_RS06930	COG0069	glutamate synthase activity
HUW48_RS06930	COG0070	glutamate synthase
HUW48_RS06980	COG1136	(ABC) transporter
HUW48_RS06990	COG4191	Histidine kinase
HUW48_RS06995	COG3279	Response regulator of the LytR AlgR family
HUW48_RS07000	COG4251	negative regulation of phosphorylation
HUW48_RS07010	COG0657	acetylesterase activity
HUW48_RS07010	COG2755	lipolytic protein G-D-S-L family
HUW48_RS07015	COG3118	belongs to the thioredoxin family
HUW48_RS07040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW48_RS07060	COG0531	amino acid
HUW48_RS07070	COG2259	Doxx family
HUW48_RS07140	COG2353	YceI-like domain
HUW48_RS07200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUW48_RS07240	COG5654	RES domain protein
HUW48_RS07280	COG1295	ribonuclease BN
HUW48_RS07315	COG1253	flavin adenine dinucleotide binding
HUW48_RS07320	COG1253	flavin adenine dinucleotide binding
HUW48_RS07355	COG3547	Transposase (IS116 IS110 IS902 family)
HUW48_RS07430	COG0196	riboflavin kinase activity
HUW48_RS07435	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUW48_RS07440	COG1968	undecaprenyl-diphosphatase activity
HUW48_RS07450	COG2177	Part of the ABC transporter FtsEX involved in
HUW48_RS07460	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUW48_RS07475	COG0439	Biotin carboxylase
HUW48_RS07485	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUW48_RS07490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUW48_RS07495	COG0416	fatty acid biosynthetic process
HUW48_RS07500	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUW48_RS07510	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HUW48_RS07515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUW48_RS07520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUW48_RS07525	COG2239	Acts as a magnesium transporter
HUW48_RS07530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUW48_RS07535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUW48_RS07570	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HUW48_RS07580	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW48_RS07595	COG0346	lactoylglutathione lyase activity
HUW48_RS07605	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUW48_RS07605	COG0617	tRNA 3'-terminal CCA addition
HUW48_RS07605	COG0517	IMP dehydrogenase activity
HUW48_RS07620	COG1695	Transcriptional regulator
HUW48_RS07645	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUW48_RS07650	COG0784	Response regulator, receiver
HUW48_RS07655	COG4251	negative regulation of phosphorylation
HUW48_RS07660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUW48_RS07665	COG2045	Belongs to the ComB family
HUW48_RS07670	COG1694	Mazg nucleotide pyrophosphohydrolase
HUW48_RS07675	COG1490	D-aminoacyl-tRNA deacylase activity
HUW48_RS07685	COG0598	Magnesium transport protein CorA
HUW48_RS07695	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW48_RS07710	COG2244	polysaccharide biosynthetic process
HUW48_RS07715	COG1215	transferase activity, transferring glycosyl groups
HUW48_RS07755	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUW48_RS07760	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HUW48_RS07765	COG1162	GTPase activity
HUW48_RS07785	COG0527	aspartate kinase activity
HUW48_RS07800	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HUW48_RS07815	COG2226	methyltransferase
HUW48_RS07825	COG4221	oxidoreductase activity
HUW48_RS07840	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HUW48_RS07845	COG0328	RNA-DNA hybrid ribonuclease activity
HUW48_RS07855	COG2095	MarC family integral membrane protein
HUW48_RS07865	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUW48_RS07870	COG4974	Belongs to the 'phage' integrase family
HUW48_RS07895	COG0167	dihydroorotate dehydrogenase activity
HUW48_RS07900	COG1674	ftsk spoiiie
HUW48_RS07915	COG0247	lactate metabolic process
HUW48_RS07915	COG0277	FAD linked oxidase domain protein
HUW48_RS07925	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUW48_RS07930	COG0791	NLP P60 protein
HUW48_RS07940	COG0539	negative regulation of cytoplasmic translation
HUW48_RS07950	COG2197	response regulator
HUW48_RS07965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUW48_RS07965	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUW48_RS07975	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HUW48_RS07990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUW48_RS07995	COG0681	Belongs to the peptidase S26 family
HUW48_RS08000	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUW48_RS08010	COG1475	DNA binding
HUW48_RS08015	COG1192	Involved in chromosome partitioning
HUW48_RS08020	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW48_RS08025	COG0747	negative chemotaxis
HUW48_RS08030	COG0706	membrane insertase activity
HUW48_RS08035	COG0504	CTP synthase activity
HUW48_RS08070	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HUW48_RS08075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUW48_RS08095	COG3217	Mosc domain protein beta barrel domain protein
HUW48_RS08095	COG0633	Ferredoxin
HUW48_RS08105	COG1129	ABC transporter
HUW48_RS08105	COG0842	Transport permease protein
HUW48_RS08110	COG0842	Transport permease protein
HUW48_RS08115	COG1131	(ABC) transporter
HUW48_RS08120	COG1131	(ABC) transporter
HUW48_RS08125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUW48_RS08145	COG2151	metal-sulfur cluster biosynthetic enzyme
HUW48_RS08150	COG2166	iron-sulfur cluster assembly
HUW48_RS08160	COG0719	Fe-S assembly protein
HUW48_RS08165	COG0396	ATPase activity
HUW48_RS08170	COG0719	Fe-S assembly protein
HUW48_RS08175	COG0316	Belongs to the HesB IscA family
HUW48_RS08190	COG0492	ferredoxin-NADP+ reductase activity
HUW48_RS08205	COG0739	heme binding
HUW48_RS08220	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HUW48_RS08285	COG2814	Major facilitator Superfamily
HUW48_RS08305	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUW48_RS08310	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUW48_RS08315	COG2080	2 iron, 2 sulfur cluster binding
HUW48_RS08325	COG0028	Belongs to the TPP enzyme family
HUW48_RS08345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUW48_RS08355	COG1278	Cold shock
HUW48_RS08370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUW48_RS08400	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS08405	COG1187	pseudouridine synthase activity
HUW48_RS08410	COG2197	response regulator
HUW48_RS08485	COG3546	catalase activity
HUW48_RS08490	COG0667	Aldo Keto reductase
HUW48_RS08510	COG0604	alcohol dehydrogenase
HUW48_RS08540	COG4302	ethanolamine ammonia-lyase activity
HUW48_RS08555	COG4771	TonB-dependent receptor
HUW48_RS08560	COG0702	epimerase
HUW48_RS08580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUW48_RS08590	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUW48_RS08615	COG3162	membrane
HUW48_RS08630	COG0183	Belongs to the thiolase family
HUW48_RS08640	COG2304	oxidoreductase activity
HUW48_RS08735	COG0039	L-malate dehydrogenase activity
HUW48_RS08835	COG0402	S-adenosylhomocysteine deaminase activity
HUW48_RS08855	COG3292	Two component regulator propeller
HUW48_RS08855	COG0745	RESPONSE REGULATOR receiver
HUW48_RS08855	COG2205	protein histidine kinase activity
HUW48_RS08880	COG0730	response to heat
HUW48_RS08895	COG2814	Major facilitator Superfamily
HUW48_RS08925	COG0431	NADPH-dependent FMN reductase
HUW48_RS08980	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HUW48_RS09020	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HUW48_RS09035	COG3547	Transposase (IS116 IS110 IS902 family)
HUW48_RS09050	COG0210	DNA helicase
HUW48_RS09080	COG3292	Two component regulator propeller
HUW48_RS09080	COG0745	RESPONSE REGULATOR receiver
HUW48_RS09080	COG2205	protein histidine kinase activity
HUW48_RS09095	COG3781	membrane
HUW48_RS09105	COG1132	(ABC) transporter
HUW48_RS09125	COG2514	catechol 2,3-dioxygenase activity
HUW48_RS09130	COG1473	amidohydrolase
HUW48_RS09180	COG3794	PFAM blue (type 1) copper domain protein
HUW48_RS09185	COG1595	DNA-templated transcription, initiation
HUW48_RS09195	COG0302	gtp cyclohydrolase
HUW48_RS09200	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS09230	COG1943	Transposase
HUW48_RS09235	COG2610	gluconate transmembrane transporter activity
HUW48_RS09245	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HUW48_RS09275	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUW48_RS09280	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUW48_RS09295	COG2217	Heavy metal translocating P-type atpase
HUW48_RS09305	COG1741	Belongs to the pirin family
HUW48_RS09340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUW48_RS09345	COG2005	Transcriptional regulator
HUW48_RS09345	COG3585	molybdate ion transport
HUW48_RS09375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUW48_RS09420	COG1609	Transcriptional regulator
HUW48_RS09430	COG0673	inositol 2-dehydrogenase activity
HUW48_RS09440	COG2814	Major facilitator Superfamily
HUW48_RS09445	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS09450	COG0673	inositol 2-dehydrogenase activity
HUW48_RS09460	COG1082	Xylose isomerase domain protein TIM barrel
HUW48_RS09475	COG4993	Dehydrogenase
HUW48_RS09490	COG1629	transport
HUW48_RS09500	COG1312	Catalyzes the dehydration of D-mannonate
HUW48_RS09510	COG1312	Catalyzes the dehydration of D-mannonate
HUW48_RS09545	COG4771	TonB-dependent receptor
HUW48_RS09550	COG4948	Mandelate Racemase Muconate Lactonizing
HUW48_RS09560	COG1629	transport
HUW48_RS09560	COG4206	TonB-dependent receptor
HUW48_RS09570	COG4948	Mandelate Racemase Muconate Lactonizing
HUW48_RS09575	COG1609	Transcriptional regulator
HUW48_RS09580	COG3734	2-keto-3-deoxy-galactonokinase
HUW48_RS09600	COG1196	nuclear chromosome segregation
HUW48_RS09615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUW48_RS09620	COG3104	oligopeptide transport
HUW48_RS09630	COG0459	protein refolding
HUW48_RS09635	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUW48_RS09655	COG3604	Transcriptional regulator
HUW48_RS09660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUW48_RS09675	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUW48_RS09680	COG1663	tetraacyldisaccharide 4'-kinase activity
HUW48_RS09710	COG0577	efflux transmembrane transporter activity
HUW48_RS09730	COG1119	ATPase activity
HUW48_RS09740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUW48_RS09745	COG1368	sulfuric ester hydrolase activity
HUW48_RS09760	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUW48_RS09770	COG2315	Protein conserved in bacteria
HUW48_RS09785	COG0784	Response regulator, receiver
HUW48_RS09785	COG2205	protein histidine kinase activity
HUW48_RS09790	COG0495	leucyl-tRNA aminoacylation
HUW48_RS09800	COG3693	PFAM glycoside hydrolase, family 10
HUW48_RS09800	COG2382	esterase
HUW48_RS09815	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HUW48_RS09820	COG1047	Peptidyl-prolyl cis-trans
HUW48_RS09850	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HUW48_RS09855	COG2223	nitrite transmembrane transporter activity
HUW48_RS09860	COG2201	protein-glutamate methylesterase activity
HUW48_RS09900	COG4191	Histidine kinase
HUW48_RS09900	COG0784	Response regulator, receiver
HUW48_RS09935	COG2766	serine protein kinase
HUW48_RS09945	COG2719	SpoVR family
HUW48_RS09970	COG5002	protein histidine kinase activity
HUW48_RS10045	COG0247	lactate metabolic process
HUW48_RS10050	COG1139	Iron-sulfur cluster binding protein
HUW48_RS10055	COG1556	Lactate utilization protein
HUW48_RS10065	COG4095	Psort location CytoplasmicMembrane, score
HUW48_RS10100	COG3940	Belongs to the glycosyl hydrolase 43 family
HUW48_RS10105	COG5002	protein histidine kinase activity
HUW48_RS10110	COG1278	Cold shock
HUW48_RS10145	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HUW48_RS10175	COG2171	N-acyltransferase activity
HUW48_RS10180	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUW48_RS10200	COG0488	(ABC) transporter
HUW48_RS10265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUW48_RS10265	COG1199	ATP-dependent helicase activity
HUW48_RS10275	COG0628	permease
HUW48_RS10295	COG4771	TonB-dependent receptor
HUW48_RS10305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUW48_RS10310	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUW48_RS10315	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUW48_RS10320	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUW48_RS10340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUW48_RS10345	COG1185	polyribonucleotide nucleotidyltransferase activity
HUW48_RS10350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUW48_RS10355	COG0492	ferredoxin-NADP+ reductase activity
HUW48_RS10360	COG0739	heme binding
HUW48_RS10370	COG0439	Biotin carboxylase
HUW48_RS10375	COG0156	8-amino-7-oxononanoate synthase activity
HUW48_RS10385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUW48_RS10410	COG0811	peptide transport
HUW48_RS10415	COG0848	biopolymer transport protein
HUW48_RS10430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUW48_RS10435	COG0135	phosphoribosylanthranilate isomerase activity
HUW48_RS10440	COG0482	sulfurtransferase activity
HUW48_RS10455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUW48_RS10470	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUW48_RS10480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUW48_RS10485	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HUW48_RS10485	COG0131	Imidazoleglycerol-phosphate dehydratase
HUW48_RS10490	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUW48_RS10495	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUW48_RS10500	COG0107	imidazoleglycerol-phosphate synthase activity
HUW48_RS10505	COG0140	phosphoribosyl-ATP diphosphatase activity
HUW48_RS10505	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUW48_RS10510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW48_RS10520	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUW48_RS10560	COG3275	phosphorelay sensor kinase activity
HUW48_RS10565	COG3279	Response regulator of the LytR AlgR family
HUW48_RS10575	COG1722	exodeoxyribonuclease VII activity
HUW48_RS10580	COG1570	exodeoxyribonuclease VII activity
HUW48_RS10595	COG0793	Belongs to the peptidase S41A family
HUW48_RS10605	COG3685	Protein conserved in bacteria
HUW48_RS10635	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HUW48_RS10650	COG3339	Conserved Protein
HUW48_RS10655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW48_RS10660	COG2081	HI0933 family
HUW48_RS10670	COG0673	inositol 2-dehydrogenase activity
HUW48_RS10680	COG3239	Fatty acid desaturase
HUW48_RS10685	COG2076	Multidrug Resistance protein
HUW48_RS10690	COG0513	Belongs to the DEAD box helicase family
HUW48_RS10700	COG1074	ATP-dependent DNA helicase activity
HUW48_RS10710	COG2887	Belongs to the helicase family. UvrD subfamily
HUW48_RS10715	COG1652	LysM domain
HUW48_RS10740	COG1741	Belongs to the pirin family
HUW48_RS10750	COG0514	ATP-dependent DNA helicase (RecQ)
HUW48_RS10760	COG1950	PFAM Membrane protein of
HUW48_RS10765	COG0010	Belongs to the arginase family
HUW48_RS10770	COG1776	CheC inhibitor of MCP methylation
HUW48_RS10775	COG0643	Histidine kinase
HUW48_RS10775	COG2198	Histidine kinase
HUW48_RS10775	COG0643	Histidine kinase
HUW48_RS10775	COG2198	Histidine kinase
HUW48_RS10780	COG2201	protein-glutamate methylesterase activity
HUW48_RS10790	COG0840	transmembrane signaling receptor activity
HUW48_RS10795	COG1192	Involved in chromosome partitioning
HUW48_RS10800	COG0588	phosphoglycerate mutase activity
HUW48_RS10810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUW48_RS10815	COG4948	Mandelate Racemase Muconate Lactonizing
HUW48_RS10820	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW48_RS10825	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HUW48_RS10830	COG0436	Aminotransferase
HUW48_RS10835	COG0534	Mate efflux family protein
HUW48_RS10845	COG0723	plastoquinol--plastocyanin reductase activity
HUW48_RS10845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUW48_RS10850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW48_RS10875	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HUW48_RS10880	COG2363	Small membrane protein
HUW48_RS10890	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUW48_RS10900	COG0494	nUDIX hydrolase
HUW48_RS10910	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUW48_RS10920	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUW48_RS10945	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HUW48_RS10965	COG0012	GTP binding
HUW48_RS10980	COG0346	lactoylglutathione lyase activity
HUW48_RS11000	COG0488	(ABC) transporter
HUW48_RS11025	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HUW48_RS11045	COG0406	alpha-ribazole phosphatase activity
HUW48_RS11060	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HUW48_RS11075	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HUW48_RS11090	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS11105	COG1446	asparaginase
HUW48_RS11115	COG1940	carbohydrate kinase activity
HUW48_RS11125	COG1629	transport
HUW48_RS11125	COG4206	TonB-dependent receptor
HUW48_RS11135	COG1609	Transcriptional regulator
HUW48_RS11150	COG3347	Dehydrogenase
HUW48_RS11150	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS11155	COG4952	isomerase
HUW48_RS11165	COG4771	TonB-dependent receptor
HUW48_RS11170	COG0702	epimerase
HUW48_RS11190	COG0673	inositol 2-dehydrogenase activity
HUW48_RS11205	COG0745	RESPONSE REGULATOR receiver
HUW48_RS11240	COG1629	transport
HUW48_RS11245	COG0702	epimerase
HUW48_RS11280	COG3254	rhamnose metabolic process
HUW48_RS11295	COG1725	Transcriptional regulator
HUW48_RS11320	COG1105	Belongs to the carbohydrate kinase PfkB family
HUW48_RS11325	COG2814	Major facilitator Superfamily
HUW48_RS11345	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HUW48_RS11355	COG0463	Glycosyl transferase, family 2
HUW48_RS11405	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUW48_RS11425	COG0137	argininosuccinate synthase activity
HUW48_RS11430	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUW48_RS11435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUW48_RS11445	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUW48_RS11450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUW48_RS11460	COG0165	Argininosuccinate lyase
HUW48_RS11465	COG5002	protein histidine kinase activity
HUW48_RS11480	COG0673	inositol 2-dehydrogenase activity
HUW48_RS11485	COG0673	inositol 2-dehydrogenase activity
HUW48_RS11500	COG0024	Methionine aminopeptidase
HUW48_RS11505	COG0673	inositol 2-dehydrogenase activity
HUW48_RS11525	COG1063	alcohol dehydrogenase
HUW48_RS11560	COG0793	Belongs to the peptidase S41A family
HUW48_RS11585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUW48_RS11640	COG2217	Heavy metal translocating P-type atpase
HUW48_RS11665	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HUW48_RS11680	COG5297	Belongs to the glycosyl hydrolase family 6
HUW48_RS11680	COG3250	beta-galactosidase activity
HUW48_RS11710	COG4946	Tricorn protease homolog
HUW48_RS11710	COG0823	Involved in the tonB-independent uptake of proteins
HUW48_RS11710	COG1506	peptidase
HUW48_RS11715	COG0583	DNA-binding transcription factor activity
HUW48_RS11725	COG0667	Aldo Keto reductase
HUW48_RS11730	COG0667	Aldo Keto reductase
HUW48_RS11740	COG0596	Alpha beta hydrolase
HUW48_RS11770	COG1538	Outer membrane efflux protein
HUW48_RS11775	COG2502	aspartate--ammonia ligase
HUW48_RS11790	COG1678	Uncharacterized ACR, COG1678
HUW48_RS11805	COG0424	maF-like protein
HUW48_RS11810	COG0667	Aldo Keto reductase
HUW48_RS11825	COG3483	tryptophan 2,3-dioxygenase activity
HUW48_RS11830	COG1760	l-serine dehydratase
HUW48_RS11865	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUW48_RS11885	COG0517	IMP dehydrogenase activity
HUW48_RS11890	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_RS11895	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_RS11905	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_RS11905	COG0649	NAD binding
HUW48_RS11910	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HUW48_RS11915	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HUW48_RS11925	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUW48_RS11930	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_RS11935	COG0839	Belongs to the complex I subunit 6 family
HUW48_RS11940	COG0713	ATP synthesis coupled electron transport
HUW48_RS11945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUW48_RS11955	COG1007	ATP synthesis coupled electron transport
HUW48_RS11970	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HUW48_RS12010	COG0022	dehydrogenase e1 component
HUW48_RS12015	COG0408	coproporphyrinogen oxidase activity
HUW48_RS12035	COG0671	phosphoesterase, PA-phosphatase related
HUW48_RS12060	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUW48_RS12065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUW48_RS12080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUW48_RS12085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUW48_RS12090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUW48_RS12105	COG0758	DNA mediated transformation
HUW48_RS12115	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUW48_RS12150	COG2132	Multicopper oxidase
HUW48_RS12185	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HUW48_RS12210	COG1629	transport
HUW48_RS12210	COG4206	TonB-dependent receptor
HUW48_RS12225	COG3275	phosphorelay sensor kinase activity
HUW48_RS12245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUW48_RS12260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW48_RS12260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUW48_RS12265	COG0730	response to heat
HUW48_RS12280	COG3119	arylsulfatase activity
HUW48_RS12295	COG5002	protein histidine kinase activity
HUW48_RS12420	COG2003	Belongs to the UPF0758 family
HUW48_RS12445	COG1629	transport
HUW48_RS12445	COG4206	TonB-dependent receptor
HUW48_RS12460	COG0038	chloride channel
HUW48_RS12465	COG0577	efflux transmembrane transporter activity
HUW48_RS12500	COG3275	phosphorelay sensor kinase activity
HUW48_RS12505	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUW48_RS12525	COG0825	malonyl-CoA metabolic process
HUW48_RS12530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW48_RS12565	COG2267	carboxylic ester hydrolase activity
HUW48_RS12570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUW48_RS12580	COG1215	transferase activity, transferring glycosyl groups
HUW48_RS12600	COG5343	regulation of RNA biosynthetic process
HUW48_RS12610	COG1012	belongs to the aldehyde dehydrogenase family
HUW48_RS12650	COG1643	Atp-dependent helicase
HUW48_RS12660	COG2161	toxin-antitoxin pair type II binding
HUW48_RS12715	COG5002	protein histidine kinase activity
HUW48_RS12740	COG0668	transmembrane transport
HUW48_RS12745	COG2354	Protein conserved in bacteria
HUW48_RS12760	COG3023	N-Acetylmuramoyl-L-alanine amidase
HUW48_RS12770	COG0501	Belongs to the peptidase M48B family
HUW48_RS12785	COG3250	beta-galactosidase activity
HUW48_RS12790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW48_RS12805	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW48_RS12845	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUW48_RS12855	COG0730	response to heat
HUW48_RS12860	COG0450	alkyl hydroperoxide reductase
HUW48_RS12875	COG1959	2 iron, 2 sulfur cluster binding
HUW48_RS12880	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUW48_RS12885	COG0737	Belongs to the 5'-nucleotidase family
HUW48_RS12915	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW48_RS12920	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW48_RS12920	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW48_RS12925	COG0784	Response regulator, receiver
HUW48_RS12925	COG4191	Histidine kinase
HUW48_RS12950	COG0778	Nitroreductase
HUW48_RS12970	COG2963	transposase activity
HUW48_RS12975	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUW48_RS12990	COG2091	lysine biosynthetic process via aminoadipic acid
HUW48_RS13000	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUW48_RS13000	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUW48_RS13005	COG0436	Aminotransferase
HUW48_RS13015	COG1215	transferase activity, transferring glycosyl groups
HUW48_RS13020	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUW48_RS13050	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HUW48_RS13055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUW48_RS13070	COG0492	ferredoxin-NADP+ reductase activity
HUW48_RS13075	COG3852	Histidine kinase
HUW48_RS13100	COG4251	negative regulation of phosphorylation
HUW48_RS13125	COG0339	signal peptide processing
HUW48_RS13140	COG3590	peptidase
HUW48_RS13150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUW48_RS13155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUW48_RS13185	COG3119	arylsulfatase activity
HUW48_RS13225	COG1904	glucuronate isomerase
HUW48_RS13230	COG0246	Mannitol dehydrogenase
HUW48_RS13235	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HUW48_RS13250	COG3153	acetyltransferase
HUW48_RS13250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUW48_RS13255	COG0124	histidyl-tRNA synthetase
HUW48_RS13260	COG2986	histidine ammonia-lyase
HUW48_RS13275	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUW48_RS13290	COG0022	dehydrogenase e1 component
HUW48_RS13290	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUW48_RS13340	COG2089	acid synthase
HUW48_RS13350	COG0028	Belongs to the TPP enzyme family
HUW48_RS13380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUW48_RS13395	COG0590	tRNA wobble adenosine to inosine editing
HUW48_RS13400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HUW48_RS13415	COG1086	Polysaccharide biosynthesis protein
HUW48_RS13425	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW48_RS13435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUW48_RS13455	COG2089	acid synthase
HUW48_RS13495	COG2884	Cell division ATP-binding protein ftsE
HUW48_RS13505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUW48_RS13520	COG3237	CsbD-like
HUW48_RS13525	COG0519	Catalyzes the synthesis of GMP from XMP
HUW48_RS13525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUW48_RS13535	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUW48_RS13570	COG1131	(ABC) transporter
HUW48_RS13575	COG0300	oxidoreductase activity
HUW48_RS13580	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUW48_RS13615	COG2169	Transcriptional regulator
HUW48_RS13645	COG0640	Transcriptional regulator
HUW48_RS13695	COG2271	Major facilitator Superfamily
HUW48_RS13710	COG4251	negative regulation of phosphorylation
HUW48_RS13715	COG1073	alpha beta
HUW48_RS13725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUW48_RS13745	COG0110	maltose O-acetyltransferase activity
HUW48_RS13765	COG4221	oxidoreductase activity
HUW48_RS13785	COG2272	Belongs to the type-B carboxylesterase lipase family
HUW48_RS13805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUW48_RS13820	COG1064	alcohol dehydrogenase
HUW48_RS13825	COG2080	2 iron, 2 sulfur cluster binding
HUW48_RS13830	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUW48_RS13835	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUW48_RS13840	COG2192	nodulation
HUW48_RS13855	COG0561	phosphatase activity
HUW48_RS13860	COG4771	TonB-dependent receptor
HUW48_RS13925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUW48_RS13945	COG4771	TonB-dependent receptor
HUW48_RS13950	COG0726	polysaccharide deacetylase
HUW48_RS13995	COG0745	RESPONSE REGULATOR receiver
HUW48_RS14000	COG5002	protein histidine kinase activity
HUW48_RS14000	COG3850	Histidine kinase
HUW48_RS14045	COG4585	Histidine kinase
HUW48_RS14050	COG2197	response regulator
HUW48_RS14065	COG0277	FAD linked oxidase domain protein
HUW48_RS14080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUW48_RS14095	COG0667	Aldo Keto reductase
HUW48_RS14110	COG0346	lactoylglutathione lyase activity
HUW48_RS14145	COG0288	reversible hydration of carbon dioxide
HUW48_RS14160	COG0745	RESPONSE REGULATOR receiver
HUW48_RS14170	COG1070	Carbohydrate kinase
HUW48_RS14175	COG2115	Belongs to the xylose isomerase family
HUW48_RS14185	COG2010	Cytochrome c
HUW48_RS14190	COG1999	signal sequence binding
HUW48_RS14220	COG1858	cytochrome C peroxidase
HUW48_RS14230	COG0673	inositol 2-dehydrogenase activity
HUW48_RS14245	COG2721	sulfolactate sulfo-lyase activity
HUW48_RS14290	COG2308	Evidence 4 Homologs of previously reported genes of
HUW48_RS14345	COG5002	protein histidine kinase activity
HUW48_RS14365	COG1252	NADH dehydrogenase
HUW48_RS14380	COG5002	protein histidine kinase activity
HUW48_RS14395	COG3275	phosphorelay sensor kinase activity
HUW48_RS14410	COG1017	nitric oxide dioxygenase activity
HUW48_RS14410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUW48_RS14425	COG4251	negative regulation of phosphorylation
HUW48_RS14435	COG2172	sigma factor antagonist activity
HUW48_RS14440	COG1366	Belongs to the anti-sigma-factor antagonist family
HUW48_RS14445	COG1366	Belongs to the anti-sigma-factor antagonist family
HUW48_RS14460	COG2963	transposase activity
HUW48_RS14485	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS14500	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUW48_RS14530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUW48_RS14545	COG2378	regulation of single-species biofilm formation
HUW48_RS14560	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HUW48_RS14570	COG3396	Phenylacetate-CoA oxygenase
HUW48_RS14585	COG2151	metal-sulfur cluster biosynthetic enzyme
HUW48_RS14615	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUW48_RS14620	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUW48_RS14625	COG0116	Belongs to the methyltransferase superfamily
HUW48_RS14630	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUW48_RS14645	COG1193	negative regulation of DNA recombination
HUW48_RS14690	COG0406	alpha-ribazole phosphatase activity
HUW48_RS14710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW48_RS14715	COG1064	alcohol dehydrogenase
HUW48_RS14720	COG0673	inositol 2-dehydrogenase activity
HUW48_RS14725	COG0438	transferase activity, transferring glycosyl groups
HUW48_RS14755	COG0022	dehydrogenase e1 component
HUW48_RS14785	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HUW48_RS14790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUW48_RS14795	COG2270	Major facilitator Superfamily
HUW48_RS14820	COG1690	Belongs to the RtcB family
HUW48_RS14825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW48_RS14845	COG3530	Putative quorum-sensing-regulated virulence factor
HUW48_RS14865	COG0628	permease
HUW48_RS14885	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUW48_RS14885	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUW48_RS14895	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HUW48_RS14900	COG0159	tryptophan synthase activity
HUW48_RS14905	COG0133	tryptophan synthase activity
HUW48_RS14910	COG0135	phosphoribosylanthranilate isomerase activity
HUW48_RS14915	COG0134	indole-3-glycerol-phosphate synthase activity
HUW48_RS14920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUW48_RS14925	COG0512	Glutamine amidotransferase of anthranilate synthase
HUW48_RS14925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUW48_RS14935	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUW48_RS14945	COG0366	Alpha amylase catalytic
HUW48_RS14985	COG1289	transmembrane transporter activity
HUW48_RS14995	COG0824	Thioesterase
HUW48_RS15000	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HUW48_RS15010	COG0009	L-threonylcarbamoyladenylate synthase
HUW48_RS15025	COG0542	response to heat
HUW48_RS15030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUW48_RS15035	COG1363	Peptidase, m42
HUW48_RS15040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUW48_RS15045	COG0789	Transcriptional regulator
HUW48_RS15055	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUW48_RS15140	COG3275	phosphorelay sensor kinase activity
HUW48_RS15160	COG4124	Belongs to the glycosyl hydrolase 26 family
HUW48_RS15170	COG4412	M6 family metalloprotease domain protein
HUW48_RS15170	COG1404	Belongs to the peptidase S8 family
HUW48_RS15190	COG3853	Toxic anion resistance protein (TelA)
HUW48_RS15200	COG2271	Major facilitator Superfamily
HUW48_RS15205	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS15215	COG0542	response to heat
HUW48_RS15250	COG0673	inositol 2-dehydrogenase activity
HUW48_RS15275	COG1472	Belongs to the glycosyl hydrolase 3 family
HUW48_RS15290	COG1309	transcriptional regulator
HUW48_RS15320	COG0628	permease
HUW48_RS15350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW48_RS15355	COG0673	inositol 2-dehydrogenase activity
HUW48_RS15465	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUW48_RS15490	COG1929	Belongs to the glycerate kinase type-1 family
HUW48_RS15495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUW48_RS15505	COG0579	oxidoreductase
HUW48_RS15510	COG2378	regulation of single-species biofilm formation
HUW48_RS15560	COG2885	chlorophyll binding
HUW48_RS15565	COG0602	queuosine metabolic process
HUW48_RS15570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUW48_RS15575	COG0481	GTPase activity
HUW48_RS15585	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW48_RS15585	COG1703	isobutyryl-CoA mutase activity
HUW48_RS15585	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW48_RS15595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUW48_RS15610	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUW48_RS15615	COG0126	phosphoglycerate kinase activity
HUW48_RS15630	COG0604	alcohol dehydrogenase
HUW48_RS15630	COG3321	synthase
HUW48_RS15635	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HUW48_RS15650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUW48_RS15650	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUW48_RS15665	COG0358	DNA primase activity
HUW48_RS15675	COG0489	protein tyrosine kinase activity
HUW48_RS15680	COG0316	Belongs to the HesB IscA family
HUW48_RS15680	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HUW48_RS15690	COG1335	isochorismatase
HUW48_RS15705	COG0514	ATP-dependent DNA helicase (RecQ)
HUW48_RS15720	COG1136	(ABC) transporter
HUW48_RS15730	COG0045	succinate-CoA ligase (ADP-forming) activity
HUW48_RS15735	COG1764	response to oxidative stress
HUW48_RS15745	COG0531	amino acid
HUW48_RS15755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUW48_RS15770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUW48_RS15775	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUW48_RS15780	COG0772	Belongs to the SEDS family
HUW48_RS15785	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUW48_RS15790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUW48_RS15795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUW48_RS15800	COG0768	penicillin binding
HUW48_RS15810	COG0275	rRNA processing
HUW48_RS15815	COG2001	Belongs to the MraZ family
HUW48_RS15830	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUW48_RS15855	COG1595	DNA-templated transcription, initiation
HUW48_RS15875	COG2333	competence protein COMEC
HUW48_RS15875	COG0658	competence protein
HUW48_RS15885	COG1702	phosphate starvation-inducible protein PhoH
HUW48_RS15905	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUW48_RS15925	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUW48_RS15950	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HUW48_RS15955	COG2255	four-way junction helicase activity
HUW48_RS15965	COG1960	acyl-CoA dehydrogenase activity
HUW48_RS15985	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUW48_RS16005	COG5632	N-Acetylmuramoyl-L-alanine amidase
HUW48_RS16005	COG3409	Peptidoglycan-binding domain 1 protein
HUW48_RS16015	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HUW48_RS16030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUW48_RS16035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUW48_RS16040	COG0247	lactate metabolic process
HUW48_RS16050	COG0248	Ppx GppA phosphatase
HUW48_RS16055	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUW48_RS16065	COG0004	ammonium transporteR
HUW48_RS16085	COG1621	beta-fructofuranosidase activity
HUW48_RS16090	COG1621	beta-fructofuranosidase activity
HUW48_RS16095	COG1621	beta-fructofuranosidase activity
HUW48_RS16105	COG4771	TonB-dependent receptor
HUW48_RS16115	COG2814	Major facilitator Superfamily
HUW48_RS16120	COG0745	RESPONSE REGULATOR receiver
HUW48_RS16120	COG2205	protein histidine kinase activity
HUW48_RS16120	COG3292	Two component regulator propeller
HUW48_RS16130	COG4124	Belongs to the glycosyl hydrolase 26 family
HUW48_RS16145	COG2197	response regulator
HUW48_RS16160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW48_RS16180	COG2814	Major facilitator Superfamily
HUW48_RS16195	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW48_RS16210	COG2610	gluconate transmembrane transporter activity
HUW48_RS16215	COG0129	dihydroxy-acid dehydratase activity
HUW48_RS16220	COG0800	Aldolase
HUW48_RS16245	COG1629	transport
HUW48_RS16255	COG2885	chlorophyll binding
HUW48_RS16325	COG1501	Belongs to the glycosyl hydrolase 31 family
HUW48_RS16340	COG3781	membrane
HUW48_RS16370	COG1132	(ABC) transporter
HUW48_RS16375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUW48_RS16385	COG0473	3-isopropylmalate dehydrogenase activity
HUW48_RS16395	COG1862	Preprotein translocase
HUW48_RS16405	COG0237	dephospho-CoA kinase activity
HUW48_RS16410	COG1312	Catalyzes the dehydration of D-mannonate
HUW48_RS16415	COG3661	Belongs to the glycosyl hydrolase 67 family
HUW48_RS16500	COG2252	PERMEase
HUW48_RS16510	COG1733	regulation of RNA biosynthetic process
HUW48_RS16565	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HUW48_RS16570	COG2086	electron transfer activity
HUW48_RS16600	COG5002	protein histidine kinase activity
HUW48_RS16605	COG0745	RESPONSE REGULATOR receiver
HUW48_RS16615	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS16620	COG0415	Belongs to the DNA photolyase family
HUW48_RS16675	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUW48_RS16680	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HUW48_RS16700	COG0829	nickel cation binding
HUW48_RS16710	COG0832	Belongs to the urease beta subunit family
HUW48_RS16750	COG0363	glucosamine-6-phosphate deaminase activity
HUW48_RS16755	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HUW48_RS16760	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUW48_RS16770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUW48_RS16775	COG0698	ribose 5-phosphate isomerase
HUW48_RS16795	COG2814	Major facilitator Superfamily
HUW48_RS16800	COG0667	Aldo Keto reductase
HUW48_RS16815	COG1796	DNA polymerase
HUW48_RS16815	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUW48_RS16835	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HUW48_RS16840	COG0540	Belongs to the ATCase OTCase family
HUW48_RS16845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUW48_RS16850	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUW48_RS16860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW48_RS16860	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW48_RS16880	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW48_RS16895	COG2814	Major facilitator Superfamily
HUW48_RS16905	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HUW48_RS16970	COG3279	Response regulator of the LytR AlgR family
HUW48_RS16975	COG0697	spore germination
HUW48_RS16985	COG3386	PFAM SMP-30 Gluconolaconase
HUW48_RS16995	COG2201	protein-glutamate methylesterase activity
HUW48_RS17010	COG1595	DNA-templated transcription, initiation
HUW48_RS17015	COG4206	TonB-dependent receptor
HUW48_RS17015	COG1629	transport
HUW48_RS17040	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUW48_RS17045	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUW48_RS17050	COG1252	NADH dehydrogenase
HUW48_RS17065	COG1640	4-alpha-glucanotransferase
HUW48_RS17085	COG5002	protein histidine kinase activity
HUW48_RS17090	COG1228	amidohydrolase
HUW48_RS17095	COG3458	cephalosporin-C deacetylase activity
HUW48_RS17100	COG5002	protein histidine kinase activity
HUW48_RS17170	COG4206	TonB-dependent receptor
HUW48_RS17170	COG1629	transport
HUW48_RS17180	COG1187	pseudouridine synthase activity
HUW48_RS17185	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HUW48_RS17190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUW48_RS17200	COG3844	kynureninase activity
HUW48_RS17205	COG3757	hydrolase, family 25
HUW48_RS17230	COG2514	catechol 2,3-dioxygenase activity
HUW48_RS17240	COG1695	Transcriptional regulator
HUW48_RS17275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUW48_RS17280	COG0387	Pfam Sodium calcium exchanger
HUW48_RS17300	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUW48_RS17305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUW48_RS17315	COG1538	Outer membrane efflux protein
HUW48_RS17350	COG1011	Hydrolase
HUW48_RS17385	COG1090	epimerase
HUW48_RS17400	COG0702	epimerase
HUW48_RS17405	COG1629	transport
HUW48_RS17410	COG0450	alkyl hydroperoxide reductase
HUW48_RS17440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUW48_RS17465	COG2855	membrane
HUW48_RS17485	COG0702	epimerase
HUW48_RS17490	COG1629	transport
HUW48_RS17515	COG1733	regulation of RNA biosynthetic process
HUW48_RS17565	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUW48_RS17570	COG0702	epimerase
HUW48_RS17575	COG4771	TonB-dependent receptor
HUW48_RS17580	COG0305	Participates in initiation and elongation during chromosome replication
HUW48_RS17585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUW48_RS17600	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUW48_RS17610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUW48_RS17615	COG2304	oxidoreductase activity
HUW48_RS17620	COG1595	DNA-templated transcription, initiation
HUW48_RS17640	COG0471	metal ion transport
HUW48_RS17640	COG3273	potassium ion transport
HUW48_RS17650	COG0205	6-phosphofructokinase activity
HUW48_RS17655	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUW48_RS17665	COG2198	Histidine kinase
HUW48_RS17665	COG5002	protein histidine kinase activity
HUW48_RS17665	COG0784	Response regulator, receiver
HUW48_RS17680	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HUW48_RS17680	COG0321	lipoyl(octanoyl) transferase activity
HUW48_RS17685	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HUW48_RS17705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW48_RS17730	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUW48_RS17750	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUW48_RS17785	COG1278	Cold shock
HUW48_RS17810	COG5654	RES domain protein
HUW48_RS17820	COG3604	Transcriptional regulator
HUW48_RS17830	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUW48_RS17925	COG0626	cystathionine gamma-synthase activity
HUW48_RS17930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUW48_RS17970	COG0077	Prephenate dehydratase
HUW48_RS17975	COG0436	Aminotransferase
HUW48_RS17980	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HUW48_RS17980	COG1605	Chorismate mutase
HUW48_RS18020	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HUW48_RS18040	COG0277	FAD linked oxidase domain protein
HUW48_RS18040	COG0247	lactate metabolic process
HUW48_RS18075	COG2223	nitrite transmembrane transporter activity
HUW48_RS18085	COG0612	Peptidase, M16
HUW48_RS18090	COG2318	DinB family
HUW48_RS18110	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS18115	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUW48_RS18135	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW48_RS18145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUW48_RS18150	COG1132	(ABC) transporter
HUW48_RS18160	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HUW48_RS18170	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUW48_RS18175	COG2885	chlorophyll binding
HUW48_RS18190	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HUW48_RS18200	COG1764	response to oxidative stress
HUW48_RS18220	COG0612	Peptidase, M16
HUW48_RS18230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW48_RS18265	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUW48_RS18270	COG0601	transmembrane transport
HUW48_RS18285	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUW48_RS18290	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HUW48_RS18310	COG2755	lipolytic protein G-D-S-L family
HUW48_RS18310	COG3401	FG-GAP repeat protein
HUW48_RS18335	COG4771	TonB-dependent receptor
HUW48_RS18355	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUW48_RS18360	COG0857	belongs to the CobB CobQ family
HUW48_RS18360	COG0280	phosphate acetyltransferase
HUW48_RS18385	COG0667	Aldo Keto reductase
HUW48_RS18390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUW48_RS18410	COG0574	Belongs to the PEP-utilizing enzyme family
HUW48_RS18410	COG3848	Pyruvate phosphate dikinase
HUW48_RS18420	COG0673	inositol 2-dehydrogenase activity
HUW48_RS18425	COG1404	Belongs to the peptidase S8 family
HUW48_RS18495	COG0363	glucosamine-6-phosphate deaminase activity
HUW48_RS18515	COG0745	RESPONSE REGULATOR receiver
HUW48_RS18515	COG3292	Two component regulator propeller
HUW48_RS18515	COG2205	protein histidine kinase activity
HUW48_RS18525	COG2267	carboxylic ester hydrolase activity
HUW48_RS18530	COG1012	belongs to the aldehyde dehydrogenase family
HUW48_RS18565	COG4771	TonB-dependent receptor
HUW48_RS18605	COG0640	Transcriptional regulator
HUW48_RS18630	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUW48_RS18650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUW48_RS18700	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUW48_RS18755	COG4134	Bacterial extracellular solute-binding protein
HUW48_RS18770	COG1115	amino acid carrier protein
HUW48_RS18785	COG4654	Cytochrome c, class I
HUW48_RS18795	COG1012	belongs to the aldehyde dehydrogenase family
HUW48_RS18835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUW48_RS18835	COG4651	solute:proton antiporter activity
HUW48_RS18880	COG1914	H( )-stimulated, divalent metal cation uptake system
HUW48_RS18885	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HUW48_RS18895	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HUW48_RS18900	COG1984	allophanate hydrolase subunit 2
HUW48_RS18915	COG0667	Aldo Keto reductase
HUW48_RS18925	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HUW48_RS18955	COG3321	synthase
HUW48_RS18955	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS18955	COG0604	alcohol dehydrogenase
HUW48_RS18960	COG2706	6-phosphogluconolactonase activity
HUW48_RS18965	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS18970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW48_RS19020	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS19035	COG1136	(ABC) transporter
HUW48_RS19045	COG0700	Nucleoside recognition
HUW48_RS19055	COG0156	8-amino-7-oxononanoate synthase activity
HUW48_RS19130	COG2205	protein histidine kinase activity
HUW48_RS19130	COG3292	Two component regulator propeller
HUW48_RS19130	COG0745	RESPONSE REGULATOR receiver
HUW48_RS19135	COG2996	Protein conserved in bacteria
HUW48_RS19155	COG0363	glucosamine-6-phosphate deaminase activity
HUW48_RS19160	COG1940	carbohydrate kinase activity
HUW48_RS19160	COG1846	Transcriptional regulator
HUW48_RS19180	COG0346	lactoylglutathione lyase activity
HUW48_RS19190	COG1125	glycine betaine transport
HUW48_RS19190	COG0517	IMP dehydrogenase activity
HUW48_RS19195	COG1174	glycine betaine transport
HUW48_RS19200	COG3279	Response regulator of the LytR AlgR family
HUW48_RS19205	COG3275	phosphorelay sensor kinase activity
HUW48_RS19215	COG2353	YceI-like domain
HUW48_RS19230	COG0802	atpase or kinase
HUW48_RS19235	COG2204	response regulator
HUW48_RS19240	COG1078	dGTPase activity
HUW48_RS19250	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUW48_RS19255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUW48_RS19255	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HUW48_RS19260	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUW48_RS19265	COG4133	protoheme IX ABC transporter activity
HUW48_RS19285	COG1546	Belongs to the CinA family
HUW48_RS19285	COG1058	Belongs to the CinA family
HUW48_RS19290	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUW48_RS19310	COG1136	(ABC) transporter
HUW48_RS19330	COG2204	response regulator
HUW48_RS19340	COG0277	FAD linked oxidase domain protein
HUW48_RS19355	COG4106	trans-aconitate 2-methyltransferase activity
HUW48_RS19365	COG0745	RESPONSE REGULATOR receiver
HUW48_RS19365	COG3292	Two component regulator propeller
HUW48_RS19365	COG2205	protein histidine kinase activity
HUW48_RS19370	COG0525	valine-tRNA ligase activity
HUW48_RS19380	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS19385	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUW48_RS19405	COG0813	purine-nucleoside phosphorylase activity
HUW48_RS19430	COG0284	orotidine-5'-phosphate decarboxylase activity
HUW48_RS19460	COG0513	Belongs to the DEAD box helicase family
HUW48_RS19475	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUW48_RS19480	COG1129	ABC transporter
HUW48_RS19500	COG0204	Acyl-transferase
HUW48_RS19500	COG0318	PFAM AMP-dependent synthetase and ligase
HUW48_RS19505	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUW48_RS19515	COG1136	(ABC) transporter
HUW48_RS19565	COG4771	TonB-dependent receptor
HUW48_RS19575	COG4771	TonB-dependent receptor
HUW48_RS19585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUW48_RS19605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUW48_RS19610	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HUW48_RS19615	COG0577	efflux transmembrane transporter activity
HUW48_RS19615	COG1136	(ABC) transporter
HUW48_RS19620	COG1611	Belongs to the LOG family
HUW48_RS19635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUW48_RS19650	COG1024	Enoyl-CoA hydratase
HUW48_RS19660	COG0017	Asparaginyl-tRNA synthetase
HUW48_RS19680	COG0193	aminoacyl-tRNA hydrolase activity
HUW48_RS19685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HUW48_RS19690	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUW48_RS19690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUW48_RS19695	COG0571	ribonuclease III activity
HUW48_RS19700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUW48_RS19705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUW48_RS19715	COG0469	pyruvate kinase activity
HUW48_RS19720	COG0268	Binds directly to 16S ribosomal RNA
HUW48_RS19725	COG0429	hydrolase of the alpha beta-hydrolase fold
HUW48_RS19740	COG0366	Alpha amylase catalytic
HUW48_RS19750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUW48_RS19765	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HUW48_RS19785	COG4974	Belongs to the 'phage' integrase family
HUW48_RS19835	COG5484	DNA packaging
HUW48_RS19835	COG3728	DNA packaging
HUW48_RS19895	COG2135	peptidase activity
HUW48_RS19955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HUW48_RS19970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUW48_RS19980	COG1970	mechanosensitive ion channel activity
HUW48_RS19985	COG1024	Enoyl-CoA hydratase
HUW48_RS19995	COG0756	dUTP diphosphatase activity
HUW48_RS20020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUW48_RS20025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUW48_RS20030	COG0154	amidase activity
HUW48_RS20035	COG0791	NLP P60 protein
HUW48_RS20035	COG1388	LysM domain
HUW48_RS20040	COG0281	malic enzyme
HUW48_RS20040	COG0280	phosphate acetyltransferase
HUW48_RS20045	COG0632	four-way junction helicase activity
HUW48_RS20055	COG0509	glycine decarboxylation via glycine cleavage system
HUW48_RS20065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUW48_RS20070	COG1561	YicC-like family, N-terminal region
HUW48_RS20075	COG0047	phosphoribosylformylglycinamidine synthase activity
HUW48_RS20095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW48_RS20100	COG1183	phosphatidylcholine synthase activity
HUW48_RS20130	COG2885	chlorophyll binding
HUW48_RS20145	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUW48_RS20160	COG3118	belongs to the thioredoxin family
HUW48_RS20175	COG0022	dehydrogenase e1 component
HUW48_RS20180	COG0612	Peptidase, M16
HUW48_RS20190	COG0667	Aldo Keto reductase
HUW48_RS20215	COG0492	ferredoxin-NADP+ reductase activity
HUW48_RS20235	COG0488	(ABC) transporter
HUW48_RS20250	COG1121	(ABC) transporter
HUW48_RS20290	COG2814	Major facilitator Superfamily
HUW48_RS20305	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS20310	COG1012	belongs to the aldehyde dehydrogenase family
HUW48_RS20315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW48_RS20320	COG0071	Belongs to the small heat shock protein (HSP20) family
HUW48_RS20330	COG1473	amidohydrolase
HUW48_RS20340	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HUW48_RS20345	COG0653	protein targeting
HUW48_RS20350	COG0248	Ppx GppA phosphatase
HUW48_RS20355	COG0116	Belongs to the methyltransferase superfamily
HUW48_RS20355	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUW48_RS20360	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUW48_RS20400	COG0148	phosphopyruvate hydratase activity
HUW48_RS20405	COG0505	Belongs to the CarA family
HUW48_RS20410	COG0203	ribosomal protein L17
HUW48_RS20415	COG0202	RNA polymerase activity
HUW48_RS20420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUW48_RS20425	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUW48_RS20430	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUW48_RS20435	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUW48_RS20440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUW48_RS20445	COG0024	Methionine aminopeptidase
HUW48_RS20450	COG0201	protein transport
HUW48_RS20455	COG0200	Binds to the 23S rRNA
HUW48_RS20460	COG1841	ribosomal large subunit assembly
HUW48_RS20465	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUW48_RS20470	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUW48_RS20475	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUW48_RS20480	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUW48_RS20485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUW48_RS20490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUW48_RS20495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUW48_RS20500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUW48_RS20505	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUW48_RS20510	COG0255	Belongs to the universal ribosomal protein uL29 family
HUW48_RS20515	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUW48_RS20520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUW48_RS20525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUW48_RS20530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUW48_RS20535	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUW48_RS20540	COG0089	rRNA binding
HUW48_RS20545	COG0088	Forms part of the polypeptide exit tunnel
HUW48_RS20550	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUW48_RS20555	COG0051	transcription antitermination factor activity, RNA binding
HUW48_RS20560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUW48_RS20565	COG0049	tRNA binding
HUW48_RS20570	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUW48_RS20585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUW48_RS20590	COG0085	RNA polymerase activity
HUW48_RS20595	COG0222	ribosome binding
HUW48_RS20600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUW48_RS20605	COG0081	regulation of translation
HUW48_RS20610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUW48_RS20650	COG0308	aminopeptidase N
HUW48_RS20660	COG0528	UMP kinase activity
HUW48_RS20665	COG0233	cytoplasmic translational termination
HUW48_RS20695	COG0191	fructose-bisphosphate aldolase activity
HUW48_RS20705	COG0004	ammonium transporteR
HUW48_RS20710	COG0788	formyltetrahydrofolate deformylase activity
HUW48_RS20720	COG3142	Participates in the control of copper homeostasis
HUW48_RS20735	COG1428	Deoxynucleoside kinase
HUW48_RS20745	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUW48_RS20750	COG0194	GDP metabolic process
HUW48_RS20760	COG1595	DNA-templated transcription, initiation
HUW48_RS20775	COG0463	Glycosyl transferase, family 2
HUW48_RS20780	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUW48_RS20790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUW48_RS20805	COG3220	belongs to the UPF0276 family
HUW48_RS20810	COG2094	Belongs to the DNA glycosylase MPG family
HUW48_RS20820	COG4206	TonB-dependent receptor
HUW48_RS20840	COG1007	ATP synthesis coupled electron transport
HUW48_RS20850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUW48_RS20855	COG0713	ATP synthesis coupled electron transport
HUW48_RS20860	COG0839	Belongs to the complex I subunit 6 family
HUW48_RS20870	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUW48_RS20875	COG0754	glutathionylspermidine amidase activity
HUW48_RS20885	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HUW48_RS20895	COG0488	(ABC) transporter
HUW48_RS20905	COG0217	transcriptional regulatory protein
HUW48_RS20910	COG0513	Belongs to the DEAD box helicase family
HUW48_RS20915	COG1575	Belongs to the MenA family. Type 1 subfamily
HUW48_RS20920	COG0386	Belongs to the glutathione peroxidase family
HUW48_RS20925	COG0018	arginyl-trna synthetase
HUW48_RS20940	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HUW48_RS20945	COG0463	Glycosyl transferase, family 2
HUW48_RS20970	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUW48_RS20985	COG0671	phosphoesterase, PA-phosphatase related
HUW48_RS20990	COG0671	phosphoesterase, PA-phosphatase related
HUW48_RS21000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUW48_RS21020	COG0463	Glycosyl transferase, family 2
HUW48_RS21035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUW48_RS21075	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUW48_RS21090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUW48_RS21100	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUW48_RS21105	COG0740	serine-type endopeptidase activity
HUW48_RS21110	COG4268	DNA restriction-modification system
HUW48_RS21115	COG1401	restriction endodeoxyribonuclease activity
HUW48_RS21120	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUW48_RS21125	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUW48_RS21135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUW48_RS21140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUW48_RS21145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW48_RS21150	COG2814	Major facilitator Superfamily
HUW48_RS21170	COG0545	Peptidyl-prolyl cis-trans isomerase
HUW48_RS21230	COG1464	Belongs to the NlpA lipoprotein family
HUW48_RS21235	COG2011	ABC-type metal ion transport system permease component
HUW48_RS21255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUW48_RS21275	COG1278	Cold shock
HUW48_RS21290	COG1774	PSP1 C-terminal conserved region
HUW48_RS21350	COG0326	Molecular chaperone. Has ATPase activity
HUW48_RS21375	COG0596	Alpha beta hydrolase
HUW48_RS21395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUW48_RS21420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW48_RS21430	COG0367	asparagine synthase
HUW48_RS21435	COG0791	NLP P60 protein
HUW48_RS21450	COG0673	inositol 2-dehydrogenase activity
HUW48_RS21470	COG3119	arylsulfatase activity
HUW48_RS21475	COG3119	arylsulfatase activity
HUW48_RS21495	COG0583	DNA-binding transcription factor activity
HUW48_RS21520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUW48_RS21525	COG2353	YceI-like domain
HUW48_RS21545	COG4948	Mandelate Racemase Muconate Lactonizing
HUW48_RS21560	COG2201	protein-glutamate methylesterase activity
HUW48_RS21570	COG1301	dicarboxylic acid transport
HUW48_RS21580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUW48_RS21595	COG1058	Belongs to the CinA family
HUW48_RS21595	COG1546	Belongs to the CinA family
HUW48_RS21615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUW48_RS21630	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HUW48_RS21635	COG0783	Belongs to the Dps family
HUW48_RS21685	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUW48_RS21690	COG3842	ATPase activity
HUW48_RS21700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUW48_RS21705	COG0681	Belongs to the peptidase S26 family
HUW48_RS21725	COG1609	Transcriptional regulator
HUW48_RS21760	COG0123	including yeast histone deacetylase and acetoin utilization protein
HUW48_RS21780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUW48_RS21785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUW48_RS21800	COG1309	transcriptional regulator
HUW48_RS21805	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUW48_RS21810	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUW48_RS21840	COG0305	Participates in initiation and elongation during chromosome replication
HUW48_RS21865	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HUW48_RS21870	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HUW48_RS21890	COG1401	restriction endodeoxyribonuclease activity
HUW48_RS21990	COG2197	response regulator
HUW48_RS21995	COG4585	Histidine kinase
HUW48_RS22035	COG0587	DNA-directed DNA polymerase activity
HUW48_RS22045	COG1396	sequence-specific DNA binding
HUW48_RS22080	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUW48_RS22080	COG2010	Cytochrome c
HUW48_RS22085	COG2080	2 iron, 2 sulfur cluster binding
HUW48_RS22105	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUW48_RS22130	COG0673	inositol 2-dehydrogenase activity
HUW48_RS22140	COG0598	Magnesium transport protein CorA
HUW48_RS22145	COG0531	amino acid
HUW48_RS22160	COG2226	methyltransferase
HUW48_RS22175	COG0318	PFAM AMP-dependent synthetase and ligase
HUW48_RS22190	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUW48_RS22295	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUW48_RS22305	COG0861	Integral membrane protein TerC family
HUW48_RS22310	COG1666	GTP binding
HUW48_RS22330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HUW48_RS22340	COG0436	Aminotransferase
HUW48_RS22365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUW48_RS22375	COG0438	transferase activity, transferring glycosyl groups
HUW48_RS22380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUW48_RS22435	COG2205	protein histidine kinase activity
HUW48_RS22435	COG0784	Response regulator, receiver
HUW48_RS22440	COG0243	molybdopterin cofactor binding
HUW48_RS22455	COG2323	membrane
HUW48_RS22480	COG0456	acetyltransferase
HUW48_RS22480	COG1214	PFAM Peptidase M22, glycoprotease
HUW48_RS22515	COG0531	amino acid
HUW48_RS22575	COG4771	TonB-dependent receptor
HUW48_RS22585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW48_RS22590	COG0601	transmembrane transport
HUW48_RS22605	COG0793	Belongs to the peptidase S41A family
HUW48_RS22655	COG4181	ATPase activity
HUW48_RS22665	COG2198	Histidine kinase
HUW48_RS22665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW48_RS22665	COG0784	Response regulator, receiver
HUW48_RS22665	COG2205	protein histidine kinase activity
HUW48_RS22675	COG1073	alpha beta
HUW48_RS22680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUW48_RS22685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUW48_RS22690	COG0440	acetolactate synthase activity
HUW48_RS22695	COG0028	Belongs to the TPP enzyme family
HUW48_RS22700	COG0129	dihydroxy-acid dehydratase activity
HUW48_RS22705	COG0460	homoserine dehydrogenase
HUW48_RS22705	COG0527	aspartate kinase activity
HUW48_RS22710	COG0083	homoserine kinase activity
HUW48_RS22715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUW48_RS22720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUW48_RS22725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUW48_RS22730	COG0066	3-isopropylmalate dehydratase activity
HUW48_RS22735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUW48_RS22740	COG4585	Histidine kinase
HUW48_RS22755	COG0667	Aldo Keto reductase
HUW48_RS22765	COG0242	peptide deformylase activity
HUW48_RS22780	COG1295	ribonuclease BN
HUW48_RS22795	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUW48_RS22815	COG3011	Protein conserved in bacteria
HUW48_RS22865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUW48_RS22870	COG0577	efflux transmembrane transporter activity
HUW48_RS22870	COG1136	(ABC) transporter
HUW48_RS22880	COG1136	(ABC) transporter
HUW48_RS22880	COG0577	efflux transmembrane transporter activity
HUW48_RS22885	COG1136	(ABC) transporter
HUW48_RS22885	COG0577	efflux transmembrane transporter activity
HUW48_RS22900	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUW48_RS22905	COG0567	Dehydrogenase, E1 component
HUW48_RS22920	COG2201	protein-glutamate methylesterase activity
HUW48_RS22925	COG2323	membrane
HUW48_RS22950	COG1027	Aspartate ammonia-lyase
HUW48_RS22995	COG1629	transport
HUW48_RS23020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUW48_RS23025	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_RS23030	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_RS23035	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW48_RS23040	COG3586	endonuclease activity
HUW48_RS23045	COG0649	NAD binding
HUW48_RS23065	COG0702	epimerase
HUW48_RS23070	COG4771	TonB-dependent receptor
HUW48_RS23100	COG0156	8-amino-7-oxononanoate synthase activity
HUW48_RS23130	COG4771	TonB-dependent receptor
HUW48_RS23160	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUW48_RS23170	COG2197	response regulator
HUW48_RS23175	COG1528	Iron-storage protein
HUW48_RS23235	COG0501	Belongs to the peptidase M48B family
HUW48_RS23245	COG4948	Mandelate Racemase Muconate Lactonizing
HUW48_RS23265	COG0612	Peptidase, M16
HUW48_RS23280	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HUW48_RS23285	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HUW48_RS23300	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HUW48_RS23335	COG3254	rhamnose metabolic process
HUW48_RS23340	COG1082	Xylose isomerase domain protein TIM barrel
HUW48_RS23345	COG1063	alcohol dehydrogenase
HUW48_RS23350	COG0667	Aldo Keto reductase
HUW48_RS23360	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUW48_RS23370	COG1132	(ABC) transporter
HUW48_RS23385	COG0606	chelatase, subunit chli
HUW48_RS23400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUW48_RS23405	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HUW48_RS23415	COG2264	protein methyltransferase activity
HUW48_RS23425	COG0149	triose-phosphate isomerase activity
HUW48_RS23475	COG0463	Glycosyl transferase, family 2
HUW48_RS23480	COG2137	regulation of response to DNA damage stimulus
HUW48_RS23495	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HUW48_RS23530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUW48_RS23545	COG4895	conserved protein (DUF2196)
HUW48_RS23560	COG0071	Belongs to the small heat shock protein (HSP20) family
HUW48_RS23565	COG0071	Belongs to the small heat shock protein (HSP20) family
HUW48_RS23585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUW48_RS23585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUW48_RS23595	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUW48_RS23600	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUW48_RS23610	COG2304	oxidoreductase activity
HUW48_RS23630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUW48_RS23660	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW48_RS23680	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUW48_RS23685	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUW48_RS23750	COG2160	L-arabinose isomerase activity
HUW48_RS23780	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW48_RS23830	COG0673	inositol 2-dehydrogenase activity
HUW48_RS23845	COG0628	permease
HUW48_RS23860	COG3279	Response regulator of the LytR AlgR family
HUW48_RS23865	COG3275	phosphorelay sensor kinase activity
HUW48_RS23880	COG4251	negative regulation of phosphorylation
HUW48_RS23885	COG2201	protein-glutamate methylesterase activity
HUW48_RS23900	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUW48_RS23915	COG4771	TonB-dependent receptor
HUW48_RS23925	COG0251	oxidation-reduction process
HUW48_RS23960	COG4771	TonB-dependent receptor
HUW48_RS23975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUW48_RS23985	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HUW48_RS23995	COG1309	transcriptional regulator
HUW48_RS24000	COG4335	DNA alkylation repair
HUW48_RS24075	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUW48_RS24135	COG1132	(ABC) transporter
HUW48_RS24150	COG3387	PFAM Glycoside hydrolase 15-related
HUW48_RS24175	COG0673	inositol 2-dehydrogenase activity
HUW48_RS24200	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS24205	COG2154	pterin-4-alpha-carbinolamine dehydratase
HUW48_RS24210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HUW48_RS24225	COG0483	inositol monophosphate 1-phosphatase activity
HUW48_RS24245	COG0668	transmembrane transport
HUW48_RS24260	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HUW48_RS24270	COG2814	Major facilitator Superfamily
HUW48_RS24290	COG0596	Alpha beta hydrolase
HUW48_RS24300	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUW48_RS24305	COG0805	protein transport
HUW48_RS24310	COG0698	ribose 5-phosphate isomerase
HUW48_RS24320	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUW48_RS24330	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUW48_RS24335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUW48_RS24345	COG1233	COG1233 Phytoene dehydrogenase and related
HUW48_RS24360	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUW48_RS24385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUW48_RS24405	COG4206	TonB-dependent receptor
HUW48_RS24405	COG1629	transport
HUW48_RS24410	COG0384	phenazine biosynthesis protein PhzF
HUW48_RS24420	COG0730	response to heat
HUW48_RS24425	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW48_RS24445	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HUW48_RS24475	COG2226	methyltransferase
HUW48_RS24515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW48_RS24540	COG1137	ATPase activity
HUW48_RS24565	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HUW48_RS24565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUW48_RS24585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUW48_RS24595	COG0297	glycogen (starch) synthase activity
HUW48_RS24600	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUW48_RS24605	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HUW48_RS24615	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUW48_RS24615	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUW48_RS24625	COG1960	acyl-CoA dehydrogenase activity
HUW48_RS24635	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HUW48_RS24650	COG0484	heat shock protein binding
HUW48_RS24655	COG0753	catalase activity
HUW48_RS24710	COG1301	dicarboxylic acid transport
HUW48_RS24740	COG0584	glycerophosphoryl diester phosphodiesterase
HUW48_RS24745	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HUW48_RS24810	COG2197	response regulator
HUW48_RS24835	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUW48_RS24845	COG3104	oligopeptide transport
HUW48_RS24855	COG0517	IMP dehydrogenase activity
HUW48_RS24855	COG0516	GMP reductase activity
HUW48_RS24860	COG4628	conserved protein (DUF2132)
HUW48_RS24885	COG1643	Atp-dependent helicase
HUW48_RS24890	COG4989	oxidoreductase activity
HUW48_RS24895	COG1187	pseudouridine synthase activity
HUW48_RS24945	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW48_RS24950	COG1040	competence protein
HUW48_RS24965	COG0708	Exodeoxyribonuclease III
HUW48_RS24980	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUW48_RS24985	COG0445	tRNA wobble uridine modification
HUW48_RS25010	COG0306	phosphate transporter
HUW48_RS25015	COG0423	glycine-tRNA ligase activity
HUW48_RS25025	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUW48_RS25030	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUW48_RS25035	COG4172	Belongs to the ABC transporter superfamily
HUW48_RS25040	COG0557	exoribonuclease II activity
HUW48_RS25045	COG0142	geranyltranstransferase activity
HUW48_RS25080	COG3685	Protein conserved in bacteria
HUW48_RS25085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUW48_RS25090	COG0217	transcriptional regulatory protein
HUW48_RS25095	COG0586	Pfam SNARE associated Golgi protein
HUW48_RS25110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUW48_RS25115	COG1051	belongs to the nudix hydrolase family
HUW48_RS25125	COG2234	aminopeptidase activity
HUW48_RS25145	COG0436	Aminotransferase
HUW48_RS25150	COG1472	Belongs to the glycosyl hydrolase 3 family
HUW48_RS25175	COG0784	Response regulator, receiver
HUW48_RS25175	COG5002	protein histidine kinase activity
HUW48_RS25180	COG2204	response regulator
HUW48_RS25195	COG2183	response to ionizing radiation
HUW48_RS25210	COG0477	Major facilitator Superfamily
HUW48_RS25225	COG2124	cytochrome p450
HUW48_RS25235	COG0673	inositol 2-dehydrogenase activity
HUW48_RS25245	COG2755	lipolytic protein G-D-S-L family
HUW48_RS25245	COG0657	acetylesterase activity
HUW48_RS25250	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HUW48_RS25260	COG0367	asparagine synthase
HUW48_RS25265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUW48_RS25275	COG1595	DNA-templated transcription, initiation
HUW48_RS25325	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW48_RS25360	COG1607	acyl-coa hydrolase
HUW48_RS25370	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUW48_RS25375	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUW48_RS25385	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUW48_RS25400	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HUW48_RS25405	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUW48_RS25410	COG1187	pseudouridine synthase activity
HUW48_RS25415	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HUW48_RS25440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUW48_RS25455	COG2211	Major facilitator Superfamily
HUW48_RS25470	COG0673	inositol 2-dehydrogenase activity
HUW48_RS25500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUW48_RS25540	COG4206	TonB-dependent receptor
HUW48_RS25540	COG1629	transport
HUW48_RS25555	COG2723	6-phospho-beta-galactosidase activity
HUW48_RS25570	COG1595	DNA-templated transcription, initiation
HUW48_RS25630	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUW48_RS25665	COG0577	efflux transmembrane transporter activity
HUW48_RS25665	COG1136	(ABC) transporter
HUW48_RS25670	COG0577	efflux transmembrane transporter activity
HUW48_RS25690	COG1136	(ABC) transporter
HUW48_RS25690	COG0577	efflux transmembrane transporter activity
HUW48_RS25705	COG0577	efflux transmembrane transporter activity
HUW48_RS25710	COG1136	(ABC) transporter
HUW48_RS25710	COG0577	efflux transmembrane transporter activity
HUW48_RS25725	COG0492	ferredoxin-NADP+ reductase activity
HUW48_RS25735	COG2226	methyltransferase
HUW48_RS25740	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUW48_RS25775	COG4771	TonB-dependent receptor
HUW48_RS25780	COG0702	epimerase
HUW48_RS25800	COG0346	lactoylglutathione lyase activity
HUW48_RS25815	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HUW48_RS25815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HUW48_RS25820	COG0745	RESPONSE REGULATOR receiver
HUW48_RS25825	COG2205	protein histidine kinase activity
HUW48_RS25845	COG0673	inositol 2-dehydrogenase activity
HUW48_RS25850	COG0688	phosphatidylethanolamine metabolic process
HUW48_RS25855	COG1956	GAF domain-containing protein
HUW48_RS25860	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUW48_RS25860	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUW48_RS25865	COG2890	protein-(glutamine-N5) methyltransferase activity
HUW48_RS25875	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HUW48_RS25880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUW48_RS25890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW48_RS25895	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HUW48_RS25900	COG1228	amidohydrolase
HUW48_RS25910	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUW48_RS25945	COG1215	transferase activity, transferring glycosyl groups
HUW48_RS25955	COG1132	(ABC) transporter
HUW48_RS25980	COG0475	glutathione-regulated potassium exporter activity
HUW48_RS25980	COG0589	response to stress
HUW48_RS26005	COG0673	inositol 2-dehydrogenase activity
HUW48_RS26015	COG1082	Xylose isomerase domain protein TIM barrel
HUW48_RS26060	COG0513	Belongs to the DEAD box helicase family
HUW48_RS26065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUW48_RS26095	COG2329	Antibiotic biosynthesis monooxygenase
HUW48_RS26110	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HUW48_RS26115	COG0594	ribonuclease P activity
HUW48_RS26165	COG1028	Short-chain dehydrogenase reductase Sdr
HUW48_RS26180	COG2271	Major facilitator Superfamily
HUW48_RS26185	COG4206	TonB-dependent receptor
HUW48_RS26185	COG1629	transport
HUW48_RS26255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUW48_RS26265	COG4974	Belongs to the 'phage' integrase family
HUW48_RS26270	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HUW48_RS26275	COG1960	acyl-CoA dehydrogenase activity
HUW48_RS26295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW48_RS26305	COG1809	phosphosulfolactate synthase activity
HUW48_RS26310	COG0586	Pfam SNARE associated Golgi protein
HUW48_RS26315	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUW48_RS26350	COG0556	nucleotide-excision repair
HUW48_RS26380	COG0583	DNA-binding transcription factor activity
HUW48_RS26385	COG4106	trans-aconitate 2-methyltransferase activity
HUW48_RS26410	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUW48_RS26410	COG1648	precorrin-2 dehydrogenase activity
HUW48_RS26415	COG0673	inositol 2-dehydrogenase activity
HUW48_RS26430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW48_RS26475	COG0726	polysaccharide deacetylase
HUW48_RS26480	COG1215	transferase activity, transferring glycosyl groups
HUW48_RS26485	COG0084	hydrolase, TatD family'
HUW48_RS26490	COG0252	asparaginase activity
HUW48_RS26510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUW48_RS26555	COG0546	phosphoglycolate phosphatase activity
HUW48_RS26585	COG0577	efflux transmembrane transporter activity
HUW48_RS26585	COG1136	(ABC) transporter
HUW48_RS26595	COG2204	response regulator
HUW48_RS26600	COG3850	Histidine kinase
HUW48_RS26600	COG5002	protein histidine kinase activity
HUW48_RS26620	COG4953	penicillin-binding protein 1C
HUW48_RS26630	COG0488	(ABC) transporter
HUW48_RS26640	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis