locus-tag	class	description
HUW51_RS00055	COG0739	heme binding
HUW51_RS00055	COG0741	lytic transglycosylase activity
HUW51_RS00055	COG1196	nuclear chromosome segregation
HUW51_RS00110	COG0671	phosphoesterase, PA-phosphatase related
HUW51_RS00120	COG0148	phosphopyruvate hydratase activity
HUW51_RS00125	COG0038	chloride channel
HUW51_RS00135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUW51_RS00145	COG0671	phosphoesterase, PA-phosphatase related
HUW51_RS00150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUW51_RS00175	COG0745	RESPONSE REGULATOR receiver
HUW51_RS00180	COG0671	phosphoesterase, PA-phosphatase related
HUW51_RS00225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUW51_RS00320	COG1064	alcohol dehydrogenase
HUW51_RS00345	COG0300	oxidoreductase activity
HUW51_RS00370	COG4804	nuclease activity
HUW51_RS00460	COG0798	PFAM Bile acid sodium symporter
HUW51_RS00470	COG1742	UPF0060 membrane protein
HUW51_RS00475	COG0671	phosphoesterase, PA-phosphatase related
HUW51_RS00480	COG2217	Heavy metal translocating P-type atpase
HUW51_RS00520	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUW51_RS00550	COG2207	Transcriptional regulator
HUW51_RS00595	COG2217	Heavy metal translocating P-type atpase
HUW51_RS00625	COG1192	Involved in chromosome partitioning
HUW51_RS00630	COG4227	nucleotidyltransferase activity
HUW51_RS00690	COG1201	RNA secondary structure unwinding
HUW51_RS00720	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUW51_RS00790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUW51_RS00795	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUW51_RS00825	COG0587	DNA-directed DNA polymerase activity
HUW51_RS00830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUW51_RS00835	COG2135	peptidase activity
HUW51_RS00865	COG2003	Belongs to the UPF0758 family
HUW51_RS00975	COG1196	nuclear chromosome segregation
HUW51_RS00975	COG0739	heme binding
HUW51_RS00975	COG0741	lytic transglycosylase activity
HUW51_RS01035	COG3239	Fatty acid desaturase
HUW51_RS01040	COG1278	Cold shock
HUW51_RS01045	COG1595	DNA-templated transcription, initiation
HUW51_RS01130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUW51_RS01135	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUW51_RS01140	COG2080	2 iron, 2 sulfur cluster binding
HUW51_RS01155	COG0702	epimerase
HUW51_RS01160	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS01180	COG0110	maltose O-acetyltransferase activity
HUW51_RS01200	COG0028	Belongs to the TPP enzyme family
HUW51_RS01205	COG1733	regulation of RNA biosynthetic process
HUW51_RS01215	COG3547	Transposase (IS116 IS110 IS902 family)
HUW51_RS01225	COG0577	efflux transmembrane transporter activity
HUW51_RS01260	COG1388	LysM domain
HUW51_RS01260	COG4932	domain protein
HUW51_RS01275	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HUW51_RS01285	COG1597	lipid kinase activity
HUW51_RS01295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUW51_RS01330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUW51_RS01335	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUW51_RS01350	COG1053	succinate dehydrogenase
HUW51_RS01360	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUW51_RS01370	COG0791	NLP P60 protein
HUW51_RS01370	COG1388	LysM domain
HUW51_RS01370	COG3103	Sh3 type 3 domain protein
HUW51_RS01385	COG3851	Histidine kinase
HUW51_RS01400	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS01410	COG3118	belongs to the thioredoxin family
HUW51_RS01425	COG0302	gtp cyclohydrolase
HUW51_RS01430	COG1090	epimerase
HUW51_RS01440	COG0823	Involved in the tonB-independent uptake of proteins
HUW51_RS01490	COG4771	TonB-dependent receptor
HUW51_RS01525	COG1629	transport
HUW51_RS01530	COG1629	transport
HUW51_RS01540	COG1595	DNA-templated transcription, initiation
HUW51_RS01550	COG1760	l-serine dehydratase
HUW51_RS01585	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUW51_RS01600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUW51_RS01610	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUW51_RS01615	COG0740	serine-type endopeptidase activity
HUW51_RS01625	COG1401	restriction endodeoxyribonuclease activity
HUW51_RS01630	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUW51_RS01635	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUW51_RS01645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUW51_RS01650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUW51_RS01655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW51_RS01660	COG2814	Major facilitator Superfamily
HUW51_RS01680	COG0545	Peptidyl-prolyl cis-trans isomerase
HUW51_RS01695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUW51_RS01700	COG0513	Belongs to the DEAD box helicase family
HUW51_RS01745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW51_RS01805	COG0673	inositol 2-dehydrogenase activity
HUW51_RS01870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUW51_RS01910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUW51_RS01920	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUW51_RS01945	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HUW51_RS01955	COG3844	kynureninase activity
HUW51_RS01960	COG3757	hydrolase, family 25
HUW51_RS01980	COG2514	catechol 2,3-dioxygenase activity
HUW51_RS02020	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUW51_RS02045	COG0357	Ribosomal RNA small subunit methyltransferase G
HUW51_RS02060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUW51_RS02070	COG1253	flavin adenine dinucleotide binding
HUW51_RS02085	COG3046	protein related to deoxyribodipyrimidine photolyase
HUW51_RS02095	COG2223	nitrite transmembrane transporter activity
HUW51_RS02100	COG1943	Transposase
HUW51_RS02105	COG2318	DinB family
HUW51_RS02145	COG2259	Doxx family
HUW51_RS02150	COG0531	amino acid
HUW51_RS02170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW51_RS02195	COG3118	belongs to the thioredoxin family
HUW51_RS02200	COG4251	negative regulation of phosphorylation
HUW51_RS02205	COG3279	Response regulator of the LytR AlgR family
HUW51_RS02210	COG4191	Histidine kinase
HUW51_RS02215	COG2204	response regulator
HUW51_RS02275	COG0067	glutamate synthase
HUW51_RS02275	COG0070	glutamate synthase
HUW51_RS02275	COG0069	glutamate synthase activity
HUW51_RS02280	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HUW51_RS02285	COG0616	signal peptide processing
HUW51_RS02290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HUW51_RS02295	COG3876	Protein conserved in bacteria
HUW51_RS02305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW51_RS02320	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS02330	COG1136	(ABC) transporter
HUW51_RS02350	COG0700	Nucleoside recognition
HUW51_RS02355	COG2027	D-alanyl-D-alanine carboxypeptidase
HUW51_RS02360	COG0156	8-amino-7-oxononanoate synthase activity
HUW51_RS02365	COG0564	pseudouridine synthase activity
HUW51_RS02370	COG5002	protein histidine kinase activity
HUW51_RS02375	COG0745	RESPONSE REGULATOR receiver
HUW51_RS02385	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUW51_RS02410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUW51_RS02415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUW51_RS02420	COG1741	Belongs to the pirin family
HUW51_RS02425	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUW51_RS02430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HUW51_RS02435	COG0577	efflux transmembrane transporter activity
HUW51_RS02435	COG1136	(ABC) transporter
HUW51_RS02440	COG1611	Belongs to the LOG family
HUW51_RS02450	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUW51_RS02465	COG1024	Enoyl-CoA hydratase
HUW51_RS02475	COG0017	Asparaginyl-tRNA synthetase
HUW51_RS02495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUW51_RS02535	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HUW51_RS02560	COG1446	asparaginase
HUW51_RS02575	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS02580	COG4993	Dehydrogenase
HUW51_RS02615	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUW51_RS02625	COG0861	Integral membrane protein TerC family
HUW51_RS02630	COG1666	GTP binding
HUW51_RS02635	COG3040	lipid binding
HUW51_RS02650	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HUW51_RS02660	COG0436	Aminotransferase
HUW51_RS02665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUW51_RS02680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUW51_RS02695	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUW51_RS02705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUW51_RS02735	COG4636	protein conserved in cyanobacteria
HUW51_RS02745	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HUW51_RS02760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUW51_RS02770	COG1970	mechanosensitive ion channel activity
HUW51_RS02775	COG1024	Enoyl-CoA hydratase
HUW51_RS02785	COG0756	dUTP diphosphatase activity
HUW51_RS02810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUW51_RS02815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUW51_RS02820	COG0154	amidase activity
HUW51_RS02830	COG0281	malic enzyme
HUW51_RS02830	COG0280	phosphate acetyltransferase
HUW51_RS02835	COG0632	four-way junction helicase activity
HUW51_RS02845	COG0509	glycine decarboxylation via glycine cleavage system
HUW51_RS02855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUW51_RS02860	COG1561	YicC-like family, N-terminal region
HUW51_RS02870	COG0047	phosphoribosylformylglycinamidine synthase activity
HUW51_RS02885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW51_RS02890	COG1183	phosphatidylcholine synthase activity
HUW51_RS02935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUW51_RS02945	COG3118	belongs to the thioredoxin family
HUW51_RS02960	COG0022	dehydrogenase e1 component
HUW51_RS02965	COG4771	TonB-dependent receptor
HUW51_RS02970	COG0612	Peptidase, M16
HUW51_RS02980	COG0667	Aldo Keto reductase
HUW51_RS03030	COG0488	(ABC) transporter
HUW51_RS03045	COG1121	(ABC) transporter
HUW51_RS03050	COG0584	glycerophosphoryl diester phosphodiesterase
HUW51_RS03075	COG2814	Major facilitator Superfamily
HUW51_RS03090	COG0300	oxidoreductase activity
HUW51_RS03095	COG1012	belongs to the aldehyde dehydrogenase family
HUW51_RS03100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW51_RS03105	COG0071	Belongs to the small heat shock protein (HSP20) family
HUW51_RS03115	COG1473	amidohydrolase
HUW51_RS03125	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HUW51_RS03130	COG0653	protein targeting
HUW51_RS03140	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUW51_RS03140	COG0116	Belongs to the methyltransferase superfamily
HUW51_RS03145	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUW51_RS03185	COG0148	phosphopyruvate hydratase activity
HUW51_RS03190	COG0505	Belongs to the CarA family
HUW51_RS03195	COG0203	ribosomal protein L17
HUW51_RS03200	COG0202	RNA polymerase activity
HUW51_RS03205	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUW51_RS03210	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUW51_RS03215	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUW51_RS03220	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUW51_RS03225	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUW51_RS03230	COG0024	Methionine aminopeptidase
HUW51_RS03235	COG0201	protein transport
HUW51_RS03240	COG0200	Binds to the 23S rRNA
HUW51_RS03245	COG1841	ribosomal large subunit assembly
HUW51_RS03250	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUW51_RS03255	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUW51_RS03260	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUW51_RS03265	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUW51_RS03270	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUW51_RS03280	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUW51_RS03285	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUW51_RS03290	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUW51_RS03295	COG0255	Belongs to the universal ribosomal protein uL29 family
HUW51_RS03300	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUW51_RS03305	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUW51_RS03310	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUW51_RS03315	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUW51_RS03320	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUW51_RS03325	COG0089	rRNA binding
HUW51_RS03330	COG0088	Forms part of the polypeptide exit tunnel
HUW51_RS03335	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUW51_RS03340	COG0051	transcription antitermination factor activity, RNA binding
HUW51_RS03345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUW51_RS03350	COG0049	tRNA binding
HUW51_RS03355	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUW51_RS03365	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUW51_RS03370	COG0085	RNA polymerase activity
HUW51_RS03375	COG0222	ribosome binding
HUW51_RS03380	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUW51_RS03385	COG0081	regulation of translation
HUW51_RS03390	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUW51_RS03430	COG0308	aminopeptidase N
HUW51_RS03435	COG0511	ligase activity, forming carbon-carbon bonds
HUW51_RS03440	COG0528	UMP kinase activity
HUW51_RS03445	COG0233	cytoplasmic translational termination
HUW51_RS03450	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUW51_RS03475	COG0191	fructose-bisphosphate aldolase activity
HUW51_RS03485	COG0004	ammonium transporteR
HUW51_RS03490	COG0788	formyltetrahydrofolate deformylase activity
HUW51_RS03505	COG3142	Participates in the control of copper homeostasis
HUW51_RS03520	COG1428	Deoxynucleoside kinase
HUW51_RS03535	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUW51_RS03540	COG0194	GDP metabolic process
HUW51_RS03550	COG1595	DNA-templated transcription, initiation
HUW51_RS03565	COG0463	Glycosyl transferase, family 2
HUW51_RS03570	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUW51_RS03610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUW51_RS03620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUW51_RS03640	COG1309	transcriptional regulator
HUW51_RS03645	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS03650	COG2353	YceI-like domain
HUW51_RS03670	COG4948	Mandelate Racemase Muconate Lactonizing
HUW51_RS03675	COG1301	dicarboxylic acid transport
HUW51_RS03685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUW51_RS03700	COG1546	Belongs to the CinA family
HUW51_RS03700	COG1058	Belongs to the CinA family
HUW51_RS03720	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW51_RS03725	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUW51_RS03730	COG1132	(ABC) transporter
HUW51_RS03740	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HUW51_RS03750	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUW51_RS03755	COG2885	chlorophyll binding
HUW51_RS03765	COG0750	zinc metalloprotease
HUW51_RS03770	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HUW51_RS03780	COG1764	response to oxidative stress
HUW51_RS03790	COG0730	response to heat
HUW51_RS03795	COG0450	alkyl hydroperoxide reductase
HUW51_RS03810	COG1959	2 iron, 2 sulfur cluster binding
HUW51_RS03815	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUW51_RS03820	COG0737	Belongs to the 5'-nucleotidase family
HUW51_RS03825	COG0737	Belongs to the 5'-nucleotidase family
HUW51_RS03840	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW51_RS03850	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW51_RS03850	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW51_RS03865	COG5642	Protein of unknown function (DUF2384)
HUW51_RS03870	COG5654	RES domain protein
HUW51_RS03895	COG0778	Nitroreductase
HUW51_RS03910	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUW51_RS03920	COG2319	Wd-40 repeat
HUW51_RS03925	COG2091	lysine biosynthetic process via aminoadipic acid
HUW51_RS03935	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUW51_RS03935	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUW51_RS03940	COG0436	Aminotransferase
HUW51_RS03950	COG2502	aspartate--ammonia ligase
HUW51_RS03955	COG0667	Aldo Keto reductase
HUW51_RS03970	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HUW51_RS03990	COG1215	transferase activity, transferring glycosyl groups
HUW51_RS04000	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUW51_RS04035	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HUW51_RS04040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUW51_RS04055	COG0525	valine-tRNA ligase activity
HUW51_RS04070	COG2204	response regulator
HUW51_RS04090	COG1136	(ABC) transporter
HUW51_RS04105	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUW51_RS04110	COG1546	Belongs to the CinA family
HUW51_RS04110	COG1058	Belongs to the CinA family
HUW51_RS04140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW51_RS04145	COG1217	gtp-binding protein TYPA
HUW51_RS04160	COG4773	Receptor
HUW51_RS04170	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HUW51_RS04185	COG2314	TM2 domain
HUW51_RS04190	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUW51_RS04195	COG5002	protein histidine kinase activity
HUW51_RS04210	COG0531	amino acid
HUW51_RS04225	COG2197	response regulator
HUW51_RS04230	COG1528	Iron-storage protein
HUW51_RS04250	COG2252	PERMEase
HUW51_RS04265	COG3250	beta-galactosidase activity
HUW51_RS04270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW51_RS04275	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW51_RS04295	COG2353	YceI-like domain
HUW51_RS04320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUW51_RS04330	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUW51_RS04350	COG0612	Peptidase, M16
HUW51_RS04355	COG0655	NAD(P)H dehydrogenase (quinone) activity
HUW51_RS04370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW51_RS04415	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUW51_RS04435	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HUW51_RS04460	COG0463	Glycosyl transferase, family 2
HUW51_RS04510	COG0149	triose-phosphate isomerase activity
HUW51_RS04520	COG2264	protein methyltransferase activity
HUW51_RS04530	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HUW51_RS04575	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUW51_RS04580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUW51_RS04610	COG0702	epimerase
HUW51_RS04650	COG0300	oxidoreductase activity
HUW51_RS04655	COG0667	Aldo Keto reductase
HUW51_RS04660	COG1902	pentaerythritol trinitrate reductase activity
HUW51_RS04665	COG1846	Transcriptional regulator
HUW51_RS04675	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUW51_RS04680	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HUW51_RS04685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUW51_RS04690	COG0552	protein localization to endoplasmic reticulum
HUW51_RS04700	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUW51_RS04705	COG1215	transferase activity, transferring glycosyl groups
HUW51_RS04710	COG0006	proline dipeptidase activity
HUW51_RS04715	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUW51_RS04725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUW51_RS04740	COG0113	porphobilinogen synthase activity
HUW51_RS04745	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUW51_RS04750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUW51_RS04750	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HUW51_RS04755	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUW51_RS04760	COG4133	protoheme IX ABC transporter activity
HUW51_RS04770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW51_RS04770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW51_RS04790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUW51_RS04800	COG0540	Belongs to the ATCase OTCase family
HUW51_RS04805	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HUW51_RS04825	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUW51_RS04825	COG1796	DNA polymerase
HUW51_RS04830	COG0859	PFAM glycosyl transferase family 9
HUW51_RS04850	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUW51_RS04855	COG0601	transmembrane transport
HUW51_RS04870	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUW51_RS04875	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HUW51_RS04900	COG0156	8-amino-7-oxononanoate synthase activity
HUW51_RS04910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW51_RS04925	COG4771	TonB-dependent receptor
HUW51_RS04950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW51_RS04955	COG3275	phosphorelay sensor kinase activity
HUW51_RS04960	COG3279	Response regulator of the LytR AlgR family
HUW51_RS04995	COG1312	Catalyzes the dehydration of D-mannonate
HUW51_RS05000	COG1312	Catalyzes the dehydration of D-mannonate
HUW51_RS05005	COG1312	Catalyzes the dehydration of D-mannonate
HUW51_RS05015	COG1629	transport
HUW51_RS05145	COG0363	glucosamine-6-phosphate deaminase activity
HUW51_RS05155	COG0159	tryptophan synthase activity
HUW51_RS05160	COG0133	tryptophan synthase activity
HUW51_RS05165	COG0135	phosphoribosylanthranilate isomerase activity
HUW51_RS05170	COG0134	indole-3-glycerol-phosphate synthase activity
HUW51_RS05175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUW51_RS05180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUW51_RS05180	COG0512	Glutamine amidotransferase of anthranilate synthase
HUW51_RS05190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUW51_RS05200	COG0366	Alpha amylase catalytic
HUW51_RS05245	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HUW51_RS05255	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HUW51_RS05275	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS05280	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUW51_RS05285	COG0784	Response regulator, receiver
HUW51_RS05285	COG2205	protein histidine kinase activity
HUW51_RS05295	COG3618	amidohydrolase
HUW51_RS05310	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUW51_RS05320	COG0596	Alpha beta hydrolase
HUW51_RS05325	COG0363	glucosamine-6-phosphate deaminase activity
HUW51_RS05330	COG1940	carbohydrate kinase activity
HUW51_RS05330	COG1846	Transcriptional regulator
HUW51_RS05335	COG2706	6-phosphogluconolactonase activity
HUW51_RS05340	COG2084	Dehydrogenase
HUW51_RS05375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUW51_RS05385	COG1629	transport
HUW51_RS05390	COG0702	epimerase
HUW51_RS05395	COG3119	arylsulfatase activity
HUW51_RS05400	COG3408	Glycogen debranching enzyme
HUW51_RS05400	COG3119	arylsulfatase activity
HUW51_RS05460	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HUW51_RS05465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUW51_RS05470	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW51_RS05500	COG1725	Transcriptional regulator
HUW51_RS05515	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS05525	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS05545	COG1012	belongs to the aldehyde dehydrogenase family
HUW51_RS05555	COG3059	membrane
HUW51_RS05560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUW51_RS05560	COG2207	Transcriptional regulator
HUW51_RS05570	COG4335	DNA alkylation repair
HUW51_RS05575	COG0697	spore germination
HUW51_RS05585	COG2197	response regulator
HUW51_RS05590	COG4771	TonB-dependent receptor
HUW51_RS05640	COG1629	transport
HUW51_RS05685	COG4251	negative regulation of phosphorylation
HUW51_RS05695	COG2172	sigma factor antagonist activity
HUW51_RS05700	COG1366	Belongs to the anti-sigma-factor antagonist family
HUW51_RS05705	COG1366	Belongs to the anti-sigma-factor antagonist family
HUW51_RS05710	COG4251	negative regulation of phosphorylation
HUW51_RS05730	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HUW51_RS05740	COG4804	nuclease activity
HUW51_RS05765	COG4677	pectinesterase activity
HUW51_RS05770	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS05775	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HUW51_RS05805	COG1629	transport
HUW51_RS05840	COG5564	TIM-barrel signal transduction protein
HUW51_RS05850	COG0584	glycerophosphoryl diester phosphodiesterase
HUW51_RS05860	COG1070	Carbohydrate kinase
HUW51_RS05865	COG1070	Carbohydrate kinase
HUW51_RS05870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUW51_RS05875	COG2814	Major facilitator Superfamily
HUW51_RS05880	COG0702	epimerase
HUW51_RS05885	COG1629	transport
HUW51_RS05890	COG1349	DNA-binding transcription factor activity
HUW51_RS05895	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HUW51_RS05905	COG0657	acetylesterase activity
HUW51_RS05905	COG2755	lipolytic protein G-D-S-L family
HUW51_RS05915	COG2271	Major facilitator Superfamily
HUW51_RS05925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUW51_RS05930	COG0702	epimerase
HUW51_RS05935	COG4771	TonB-dependent receptor
HUW51_RS05940	COG2186	Transcriptional regulator
HUW51_RS05955	COG1278	Cold shock
HUW51_RS05970	COG1774	PSP1 C-terminal conserved region
HUW51_RS05990	COG1556	Lactate utilization protein
HUW51_RS05995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUW51_RS06000	COG0799	negative regulation of ribosome biogenesis
HUW51_RS06025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUW51_RS06030	COG0612	Peptidase, M16
HUW51_RS06035	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUW51_RS06050	COG1555	photosystem II stabilization
HUW51_RS06050	COG1596	polysaccharide export
HUW51_RS06070	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HUW51_RS06075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW51_RS06080	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HUW51_RS06090	COG0297	glycogen (starch) synthase activity
HUW51_RS06110	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HUW51_RS06135	COG0438	transferase activity, transferring glycosyl groups
HUW51_RS06140	COG0438	transferase activity, transferring glycosyl groups
HUW51_RS06145	COG1216	Glycosyl transferase, family 2
HUW51_RS06185	COG0492	ferredoxin-NADP+ reductase activity
HUW51_RS06195	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HUW51_RS06205	COG1215	transferase activity, transferring glycosyl groups
HUW51_RS06210	COG5002	protein histidine kinase activity
HUW51_RS06210	COG2198	Histidine kinase
HUW51_RS06210	COG0784	Response regulator, receiver
HUW51_RS06215	COG0745	RESPONSE REGULATOR receiver
HUW51_RS06220	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUW51_RS06240	COG1216	Glycosyl transferase, family 2
HUW51_RS06240	COG0463	Glycosyl transferase, family 2
HUW51_RS06250	COG2755	lipolytic protein G-D-S-L family
HUW51_RS06250	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUW51_RS06260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUW51_RS06295	COG3123	guanosine phosphorylase activity
HUW51_RS06310	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HUW51_RS06315	COG4654	Cytochrome c, class I
HUW51_RS06330	COG0612	Peptidase, M16
HUW51_RS06335	COG0438	transferase activity, transferring glycosyl groups
HUW51_RS06340	COG0006	proline dipeptidase activity
HUW51_RS06345	COG2885	chlorophyll binding
HUW51_RS06365	COG0419	ATPase involved in DNA repair
HUW51_RS06370	COG0420	3'-5' exonuclease activity
HUW51_RS06375	COG2201	protein-glutamate methylesterase activity
HUW51_RS06380	COG0039	L-malate dehydrogenase activity
HUW51_RS06385	COG0037	tRNA processing
HUW51_RS06420	COG0497	DNA recombination
HUW51_RS06425	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUW51_RS06430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUW51_RS06430	COG0662	Cupin 2, conserved barrel domain protein
HUW51_RS06450	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUW51_RS06540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUW51_RS06545	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW51_RS06550	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW51_RS06555	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW51_RS06560	COG0649	NAD binding
HUW51_RS06565	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HUW51_RS06565	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUW51_RS06580	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
HUW51_RS06585	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUW51_RS06590	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUW51_RS06595	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUW51_RS06600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUW51_RS06605	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUW51_RS06610	COG0356	it plays a direct role in the translocation of protons across the membrane
HUW51_RS06635	COG0322	excinuclease ABC activity
HUW51_RS06640	COG1289	transmembrane transporter activity
HUW51_RS06660	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW51_RS06680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUW51_RS06690	COG0321	lipoyl(octanoyl) transferase activity
HUW51_RS06695	COG0166	Belongs to the GPI family
HUW51_RS06700	COG0792	nuclease activity
HUW51_RS06735	COG1505	serine-type exopeptidase activity
HUW51_RS06760	COG2852	Protein conserved in bacteria
HUW51_RS06780	COG1704	LemA family
HUW51_RS06825	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUW51_RS06825	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUW51_RS06835	COG2223	nitrite transmembrane transporter activity
HUW51_RS06850	COG4864	UPF0365 protein
HUW51_RS06865	COG0662	Cupin 2, conserved barrel domain protein
HUW51_RS06875	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS06905	COG0442	prolyl-tRNA aminoacylation
HUW51_RS06910	COG0673	inositol 2-dehydrogenase activity
HUW51_RS06915	COG1085	galactose-1-phosphate uridylyltransferase
HUW51_RS06920	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUW51_RS06930	COG4654	Cytochrome c, class I
HUW51_RS06935	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HUW51_RS06940	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW51_RS06945	COG3940	Belongs to the glycosyl hydrolase 43 family
HUW51_RS06975	COG4771	TonB-dependent receptor
HUW51_RS07010	COG0793	Belongs to the peptidase S41A family
HUW51_RS07030	COG2885	chlorophyll binding
HUW51_RS07030	COG3047	cAMP biosynthetic process
HUW51_RS07045	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HUW51_RS07055	COG4181	ATPase activity
HUW51_RS07065	COG0745	RESPONSE REGULATOR receiver
HUW51_RS07075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUW51_RS07080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUW51_RS07085	COG0440	acetolactate synthase activity
HUW51_RS07090	COG0028	Belongs to the TPP enzyme family
HUW51_RS07100	COG0129	dihydroxy-acid dehydratase activity
HUW51_RS07105	COG0527	aspartate kinase activity
HUW51_RS07105	COG0460	homoserine dehydrogenase
HUW51_RS07110	COG0083	homoserine kinase activity
HUW51_RS07115	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUW51_RS07120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUW51_RS07125	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUW51_RS07130	COG0066	3-isopropylmalate dehydratase activity
HUW51_RS07170	COG0473	3-isopropylmalate dehydrogenase activity
HUW51_RS07180	COG3158	transport of potassium into the cell
HUW51_RS07200	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW51_RS07210	COG2205	protein histidine kinase activity
HUW51_RS07210	COG0784	Response regulator, receiver
HUW51_RS07225	COG0673	inositol 2-dehydrogenase activity
HUW51_RS07235	COG0657	acetylesterase activity
HUW51_RS07235	COG2755	lipolytic protein G-D-S-L family
HUW51_RS07295	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW51_RS07335	COG1607	acyl-coa hydrolase
HUW51_RS07345	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUW51_RS07350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUW51_RS07360	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUW51_RS07375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HUW51_RS07380	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUW51_RS07385	COG1187	pseudouridine synthase activity
HUW51_RS07390	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HUW51_RS07410	COG1253	flavin adenine dinucleotide binding
HUW51_RS07415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUW51_RS07425	COG5002	protein histidine kinase activity
HUW51_RS07430	COG0745	RESPONSE REGULATOR receiver
HUW51_RS07435	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HUW51_RS07435	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HUW51_RS07450	COG0346	lactoylglutathione lyase activity
HUW51_RS07460	COG1137	ATPase activity
HUW51_RS07480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUW51_RS07480	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HUW51_RS07485	COG1295	ribonuclease BN
HUW51_RS07490	COG0251	oxidation-reduction process
HUW51_RS07495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUW51_RS07505	COG0297	glycogen (starch) synthase activity
HUW51_RS07510	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUW51_RS07515	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HUW51_RS07525	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUW51_RS07525	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUW51_RS07535	COG1960	acyl-CoA dehydrogenase activity
HUW51_RS07545	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HUW51_RS07560	COG0484	heat shock protein binding
HUW51_RS07565	COG0753	catalase activity
HUW51_RS07580	COG3781	membrane
HUW51_RS07595	COG0247	lactate metabolic process
HUW51_RS07595	COG2181	nitrate reductase activity
HUW51_RS07600	COG2181	nitrate reductase activity
HUW51_RS07600	COG0247	lactate metabolic process
HUW51_RS07610	COG2885	chlorophyll binding
HUW51_RS07615	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUW51_RS07630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUW51_RS07635	COG0805	protein transport
HUW51_RS07650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUW51_RS07660	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUW51_RS07665	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUW51_RS07675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUW51_RS07695	COG1136	(ABC) transporter
HUW51_RS07695	COG0577	efflux transmembrane transporter activity
HUW51_RS07705	COG1136	(ABC) transporter
HUW51_RS07705	COG0577	efflux transmembrane transporter activity
HUW51_RS07735	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUW51_RS07760	COG0577	efflux transmembrane transporter activity
HUW51_RS07765	COG0577	efflux transmembrane transporter activity
HUW51_RS07775	COG1136	(ABC) transporter
HUW51_RS07775	COG0577	efflux transmembrane transporter activity
HUW51_RS07790	COG0477	Major facilitator Superfamily
HUW51_RS07805	COG2183	response to ionizing radiation
HUW51_RS07820	COG2204	response regulator
HUW51_RS07825	COG5002	protein histidine kinase activity
HUW51_RS07825	COG0784	Response regulator, receiver
HUW51_RS07855	COG1472	Belongs to the glycosyl hydrolase 3 family
HUW51_RS07860	COG0436	Aminotransferase
HUW51_RS07865	COG0823	Involved in the tonB-independent uptake of proteins
HUW51_RS07875	COG2234	aminopeptidase activity
HUW51_RS07880	COG1051	belongs to the nudix hydrolase family
HUW51_RS07885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUW51_RS07910	COG0586	Pfam SNARE associated Golgi protein
HUW51_RS07920	COG0217	transcriptional regulatory protein
HUW51_RS07930	COG3685	Protein conserved in bacteria
HUW51_RS07950	COG0705	Rhomboid family
HUW51_RS07955	COG0142	geranyltranstransferase activity
HUW51_RS07960	COG0557	exoribonuclease II activity
HUW51_RS07970	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUW51_RS07975	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUW51_RS07985	COG0423	glycine-tRNA ligase activity
HUW51_RS07990	COG0306	phosphate transporter
HUW51_RS08015	COG0445	tRNA wobble uridine modification
HUW51_RS08020	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUW51_RS08035	COG0708	Exodeoxyribonuclease III
HUW51_RS08050	COG1040	competence protein
HUW51_RS08055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW51_RS08095	COG1187	pseudouridine synthase activity
HUW51_RS08100	COG4989	oxidoreductase activity
HUW51_RS08105	COG1643	Atp-dependent helicase
HUW51_RS08125	COG4628	conserved protein (DUF2132)
HUW51_RS08130	COG2239	Acts as a magnesium transporter
HUW51_RS08145	COG3104	oligopeptide transport
HUW51_RS08155	COG5265	(ABC) transporter
HUW51_RS08205	COG2814	Major facilitator Superfamily
HUW51_RS08215	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HUW51_RS08230	COG0668	transmembrane transport
HUW51_RS08250	COG0483	inositol monophosphate 1-phosphatase activity
HUW51_RS08265	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HUW51_RS08270	COG2304	oxidoreductase activity
HUW51_RS08290	COG2255	four-way junction helicase activity
HUW51_RS08310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUW51_RS08315	COG0346	lactoylglutathione lyase activity
HUW51_RS08320	COG1473	amidohydrolase
HUW51_RS08330	COG0527	aspartate kinase activity
HUW51_RS08340	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HUW51_RS08340	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HUW51_RS08365	COG0673	inositol 2-dehydrogenase activity
HUW51_RS08410	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS08425	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUW51_RS08430	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUW51_RS08470	COG4895	conserved protein (DUF2196)
HUW51_RS08490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW51_RS08505	COG0590	tRNA wobble adenosine to inosine editing
HUW51_RS08510	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HUW51_RS08555	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HUW51_RS08575	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW51_RS08580	COG0730	response to heat
HUW51_RS08590	COG0384	phenazine biosynthesis protein PhzF
HUW51_RS08600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUW51_RS08625	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUW51_RS08645	COG1629	transport
HUW51_RS08645	COG4206	TonB-dependent receptor
HUW51_RS08655	COG1233	COG1233 Phytoene dehydrogenase and related
HUW51_RS08665	COG0577	efflux transmembrane transporter activity
HUW51_RS08670	COG0577	efflux transmembrane transporter activity
HUW51_RS08720	COG1629	transport
HUW51_RS08725	COG4948	Mandelate Racemase Muconate Lactonizing
HUW51_RS08735	COG4206	TonB-dependent receptor
HUW51_RS08735	COG1629	transport
HUW51_RS08745	COG4948	Mandelate Racemase Muconate Lactonizing
HUW51_RS08750	COG1609	Transcriptional regulator
HUW51_RS08755	COG3734	2-keto-3-deoxy-galactonokinase
HUW51_RS08760	COG0800	Aldolase
HUW51_RS08790	COG0702	epimerase
HUW51_RS08795	COG4771	TonB-dependent receptor
HUW51_RS08815	COG0352	thiamine-phosphate diphosphorylase activity
HUW51_RS08820	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HUW51_RS08825	COG2226	methyltransferase
HUW51_RS08840	COG1309	transcriptional regulator
HUW51_RS08855	COG4221	oxidoreductase activity
HUW51_RS08860	COG1794	racemase activity, acting on amino acids and derivatives
HUW51_RS08865	COG1733	regulation of RNA biosynthetic process
HUW51_RS08870	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUW51_RS08875	COG1733	regulation of RNA biosynthetic process
HUW51_RS08880	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS08925	COG0577	efflux transmembrane transporter activity
HUW51_RS08930	COG0577	efflux transmembrane transporter activity
HUW51_RS08960	COG1136	(ABC) transporter
HUW51_RS08960	COG0577	efflux transmembrane transporter activity
HUW51_RS08975	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS09015	COG1609	Transcriptional regulator
HUW51_RS09020	COG4771	TonB-dependent receptor
HUW51_RS09025	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HUW51_RS09030	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HUW51_RS09115	COG2323	membrane
HUW51_RS09125	COG2353	YceI-like domain
HUW51_RS09160	COG1595	DNA-templated transcription, initiation
HUW51_RS09165	COG2852	Protein conserved in bacteria
HUW51_RS09170	COG2723	6-phospho-beta-galactosidase activity
HUW51_RS09185	COG1629	transport
HUW51_RS09185	COG4206	TonB-dependent receptor
HUW51_RS09220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUW51_RS09245	COG0673	inositol 2-dehydrogenase activity
HUW51_RS09265	COG2211	Major facilitator Superfamily
HUW51_RS09290	COG0714	Associated with various cellular activities
HUW51_RS09305	COG2226	methyltransferase
HUW51_RS09310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUW51_RS09345	COG1138	Cytochrome C-type biogenesis protein
HUW51_RS09355	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HUW51_RS09360	COG1278	Cold shock
HUW51_RS09370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HUW51_RS09375	COG0138	bifunctional purine biosynthesis protein purh
HUW51_RS09380	COG1077	Cell shape determining protein MreB Mrl
HUW51_RS09395	COG0768	penicillin binding
HUW51_RS09400	COG0772	Belongs to the SEDS family
HUW51_RS09415	COG1435	thymidine kinase activity
HUW51_RS09430	COG1381	Involved in DNA repair and RecF pathway recombination
HUW51_RS09440	COG0545	Peptidyl-prolyl cis-trans isomerase
HUW51_RS09445	COG0545	Peptidyl-prolyl cis-trans isomerase
HUW51_RS09450	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUW51_RS09455	COG0105	UTP biosynthetic process
HUW51_RS09470	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUW51_RS09470	COG5180	pathogenesis
HUW51_RS09475	COG0195	Participates in both transcription termination and antitermination
HUW51_RS09490	COG0215	cysteine-tRNA ligase activity
HUW51_RS09495	COG1619	proteins homologs of microcin C7 resistance protein MccF
HUW51_RS09505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUW51_RS09510	COG2873	o-acetylhomoserine
HUW51_RS09515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HUW51_RS09540	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUW51_RS09545	COG1522	sequence-specific DNA binding
HUW51_RS09575	COG4771	TonB-dependent receptor
HUW51_RS09600	COG3254	rhamnose metabolic process
HUW51_RS09610	COG1063	alcohol dehydrogenase
HUW51_RS09615	COG0667	Aldo Keto reductase
HUW51_RS09620	COG1063	alcohol dehydrogenase
HUW51_RS09625	COG1082	Xylose isomerase domain protein TIM barrel
HUW51_RS09630	COG3254	rhamnose metabolic process
HUW51_RS09675	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HUW51_RS09700	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HUW51_RS09715	COG0612	Peptidase, M16
HUW51_RS09735	COG4948	Mandelate Racemase Muconate Lactonizing
HUW51_RS09790	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW51_RS09805	COG2197	response regulator
HUW51_RS09825	COG4124	Belongs to the glycosyl hydrolase 26 family
HUW51_RS09835	COG0004	ammonium transporteR
HUW51_RS09845	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUW51_RS09850	COG0248	Ppx GppA phosphatase
HUW51_RS09855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUW51_RS09860	COG0247	lactate metabolic process
HUW51_RS09865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUW51_RS09870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUW51_RS09905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW51_RS09925	COG2329	Antibiotic biosynthesis monooxygenase
HUW51_RS09940	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HUW51_RS09945	COG0594	ribonuclease P activity
HUW51_RS09950	COG0793	Belongs to the peptidase S41A family
HUW51_RS09995	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS10010	COG2271	Major facilitator Superfamily
HUW51_RS10030	COG1629	transport
HUW51_RS10060	COG1301	dicarboxylic acid transport
HUW51_RS10070	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUW51_RS10125	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUW51_RS10195	COG1858	cytochrome C peroxidase
HUW51_RS10215	COG0656	L-ascorbic acid biosynthetic process
HUW51_RS10220	COG0667	Aldo Keto reductase
HUW51_RS10260	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUW51_RS10260	COG2010	Cytochrome c
HUW51_RS10295	COG0464	growth
HUW51_RS10310	COG0626	cystathionine gamma-synthase activity
HUW51_RS10320	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUW51_RS10350	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HUW51_RS10370	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HUW51_RS10370	COG1605	Chorismate mutase
HUW51_RS10380	COG0077	Prephenate dehydratase
HUW51_RS10390	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HUW51_RS10405	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HUW51_RS10425	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HUW51_RS10430	COG4771	TonB-dependent receptor
HUW51_RS10435	COG0702	epimerase
HUW51_RS10450	COG0535	radical SAM domain protein
HUW51_RS10480	COG0596	Alpha beta hydrolase
HUW51_RS10565	COG2366	antibiotic biosynthetic process
HUW51_RS10595	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUW51_RS10605	COG4974	Belongs to the 'phage' integrase family
HUW51_RS10610	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HUW51_RS10615	COG1960	acyl-CoA dehydrogenase activity
HUW51_RS10625	COG0489	protein tyrosine kinase activity
HUW51_RS10625	COG3206	protein involved in exopolysaccharide biosynthesis
HUW51_RS10635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW51_RS10645	COG1809	phosphosulfolactate synthase activity
HUW51_RS10650	COG0586	Pfam SNARE associated Golgi protein
HUW51_RS10655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUW51_RS10685	COG0556	nucleotide-excision repair
HUW51_RS10695	COG0431	NADPH-dependent FMN reductase
HUW51_RS10720	COG0583	DNA-binding transcription factor activity
HUW51_RS10760	COG4206	TonB-dependent receptor
HUW51_RS10770	COG2094	Belongs to the DNA glycosylase MPG family
HUW51_RS10775	COG3220	belongs to the UPF0276 family
HUW51_RS10785	COG0300	oxidoreductase activity
HUW51_RS10790	COG0024	Methionine aminopeptidase
HUW51_RS10820	COG3173	Aminoglycoside phosphotransferase
HUW51_RS10855	COG1595	DNA-templated transcription, initiation
HUW51_RS10865	COG4771	TonB-dependent receptor
HUW51_RS10870	COG0702	epimerase
HUW51_RS10900	COG0488	(ABC) transporter
HUW51_RS10960	COG4771	TonB-dependent receptor
HUW51_RS10975	COG0702	epimerase
HUW51_RS10980	COG4771	TonB-dependent receptor
HUW51_RS10990	COG3279	Response regulator of the LytR AlgR family
HUW51_RS11000	COG0857	belongs to the CobB CobQ family
HUW51_RS11000	COG0280	phosphate acetyltransferase
HUW51_RS11005	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUW51_RS11025	COG0584	glycerophosphoryl diester phosphodiesterase
HUW51_RS11030	COG1139	Iron-sulfur cluster binding protein
HUW51_RS11035	COG4941	Belongs to the sigma-70 factor family
HUW51_RS11065	COG2234	aminopeptidase activity
HUW51_RS11070	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUW51_RS11075	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HUW51_RS11085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUW51_RS11110	COG0673	inositol 2-dehydrogenase activity
HUW51_RS11120	COG0488	(ABC) transporter
HUW51_RS11125	COG1477	protein flavinylation
HUW51_RS11130	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HUW51_RS11150	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HUW51_RS11155	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HUW51_RS11190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUW51_RS11205	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUW51_RS11225	COG0564	pseudouridine synthase activity
HUW51_RS11235	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HUW51_RS11250	COG0848	biopolymer transport protein
HUW51_RS11265	COG3956	TIGRFAM MazG family protein
HUW51_RS11270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUW51_RS11275	COG1104	cysteine desulfurase activity
HUW51_RS11280	COG0009	L-threonylcarbamoyladenylate synthase
HUW51_RS11290	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HUW51_RS11295	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUW51_RS11300	COG1160	GTP binding
HUW51_RS11320	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HUW51_RS11330	COG2814	Major facilitator Superfamily
HUW51_RS11355	COG0277	FAD linked oxidase domain protein
HUW51_RS11375	COG4682	membrane
HUW51_RS11405	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HUW51_RS11425	COG1022	Amp-dependent synthetase and ligase
HUW51_RS11435	COG1024	Enoyl-CoA hydratase
HUW51_RS11435	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUW51_RS11440	COG0183	Belongs to the thiolase family
HUW51_RS11450	COG1960	acyl-CoA dehydrogenase activity
HUW51_RS11460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HUW51_RS11470	COG4535	Mg2 and Co2 transporter CorC
HUW51_RS11475	COG0629	single-stranded DNA binding
HUW51_RS11480	COG1194	a g-specific adenine glycosylase
HUW51_RS11485	COG0776	regulation of translation
HUW51_RS11495	COG1530	ribonuclease E activity
HUW51_RS11515	COG1078	dGTPase activity
HUW51_RS11520	COG2204	response regulator
HUW51_RS11525	COG0802	atpase or kinase
HUW51_RS11550	COG4206	TonB-dependent receptor
HUW51_RS11555	COG3275	phosphorelay sensor kinase activity
HUW51_RS11560	COG3279	Response regulator of the LytR AlgR family
HUW51_RS11575	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS11600	COG1629	transport
HUW51_RS11605	COG0702	epimerase
HUW51_RS11625	COG2855	membrane
HUW51_RS11650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUW51_RS11665	COG0450	alkyl hydroperoxide reductase
HUW51_RS11670	COG1629	transport
HUW51_RS11675	COG0702	epimerase
HUW51_RS11690	COG1090	epimerase
HUW51_RS11735	COG1418	mRNA catabolic process
HUW51_RS11750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW51_RS11750	COG0072	phenylalanine-tRNA ligase activity
HUW51_RS11760	COG2003	Belongs to the UPF0758 family
HUW51_RS11785	COG0667	Aldo Keto reductase
HUW51_RS11790	COG4585	Histidine kinase
HUW51_RS11820	COG1609	Transcriptional regulator
HUW51_RS11825	COG4771	TonB-dependent receptor
HUW51_RS11835	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HUW51_RS11840	COG0673	inositol 2-dehydrogenase activity
HUW51_RS11860	COG0606	chelatase, subunit chli
HUW51_RS11870	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUW51_RS11880	COG1132	(ABC) transporter
HUW51_RS11890	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUW51_RS11900	COG4771	TonB-dependent receptor
HUW51_RS11935	COG0823	Involved in the tonB-independent uptake of proteins
HUW51_RS11940	COG2207	Transcriptional regulator
HUW51_RS11955	COG3292	Two component regulator propeller
HUW51_RS11955	COG2205	protein histidine kinase activity
HUW51_RS11955	COG0745	RESPONSE REGULATOR receiver
HUW51_RS11985	COG2197	response regulator
HUW51_RS11990	COG4585	Histidine kinase
HUW51_RS11995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUW51_RS12010	COG2223	nitrite transmembrane transporter activity
HUW51_RS12015	COG0243	molybdopterin cofactor binding
HUW51_RS12025	COG0303	'Molybdopterin
HUW51_RS12040	COG0315	cyclic pyranopterin monophosphate synthase activity
HUW51_RS12040	COG0746	molybdenum cofactor guanylyltransferase activity
HUW51_RS12050	COG0314	molybdopterin synthase activity
HUW51_RS12060	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUW51_RS12065	COG1007	ATP synthesis coupled electron transport
HUW51_RS12070	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW51_RS12080	COG0713	ATP synthesis coupled electron transport
HUW51_RS12085	COG0839	Belongs to the complex I subunit 6 family
HUW51_RS12090	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW51_RS12095	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUW51_RS12100	COG1034	ATP synthesis coupled electron transport
HUW51_RS12110	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HUW51_RS12115	COG0649	NAD binding
HUW51_RS12120	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW51_RS12125	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW51_RS12130	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUW51_RS12135	COG0657	acetylesterase activity
HUW51_RS12135	COG2755	lipolytic protein G-D-S-L family
HUW51_RS12140	COG1012	belongs to the aldehyde dehydrogenase family
HUW51_RS12175	COG0626	cystathionine gamma-synthase activity
HUW51_RS12185	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUW51_RS12200	COG0343	queuine tRNA-ribosyltransferase activity
HUW51_RS12205	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUW51_RS12215	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HUW51_RS12220	COG0254	rRNA binding
HUW51_RS12225	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUW51_RS12235	COG0470	DNA polymerase III
HUW51_RS12240	COG0181	hydroxymethylbilane synthase activity
HUW51_RS12255	COG2226	methyltransferase
HUW51_RS12265	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUW51_RS12270	COG1331	Highly conserved protein containing a thioredoxin domain
HUW51_RS12280	COG0359	binds to the 23S rRNA
HUW51_RS12285	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUW51_RS12290	COG0360	Binds together with S18 to 16S ribosomal RNA
HUW51_RS12300	COG0437	4 iron, 4 sulfur cluster binding
HUW51_RS12330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUW51_RS12340	COG0109	protoheme IX farnesyltransferase activity
HUW51_RS12345	COG1845	cytochrome c oxidase, subunit III
HUW51_RS12350	COG1845	cytochrome c oxidase, subunit III
HUW51_RS12360	COG1999	signal sequence binding
HUW51_RS12365	COG2322	membrane
HUW51_RS12375	COG5000	phosphorelay sensor kinase activity
HUW51_RS12445	COG0101	tRNA pseudouridine synthase activity
HUW51_RS12450	COG1132	(ABC) transporter
HUW51_RS12485	COG4771	TonB-dependent receptor
HUW51_RS12490	COG0702	epimerase
HUW51_RS12520	COG0673	inositol 2-dehydrogenase activity
HUW51_RS12555	COG0363	glucosamine-6-phosphate deaminase activity
HUW51_RS12565	COG2222	sugar isomerase
HUW51_RS12575	COG5652	VanZ like family
HUW51_RS12580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUW51_RS12595	COG4946	Tricorn protease homolog
HUW51_RS12595	COG0823	Involved in the tonB-independent uptake of proteins
HUW51_RS12595	COG1506	peptidase
HUW51_RS12600	COG1629	transport
HUW51_RS12605	COG0702	epimerase
HUW51_RS12620	COG1349	DNA-binding transcription factor activity
HUW51_RS12640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUW51_RS12640	COG2207	Transcriptional regulator
HUW51_RS12655	COG0793	Belongs to the peptidase S41A family
HUW51_RS12660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUW51_RS12665	COG0242	peptide deformylase activity
HUW51_RS12675	COG2217	Heavy metal translocating P-type atpase
HUW51_RS12685	COG1295	ribonuclease BN
HUW51_RS12705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUW51_RS12725	COG3011	Protein conserved in bacteria
HUW51_RS12750	COG2323	membrane
HUW51_RS12780	COG4771	TonB-dependent receptor
HUW51_RS12795	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUW51_RS12800	COG0567	Dehydrogenase, E1 component
HUW51_RS12810	COG4999	Histidine kinase
HUW51_RS12810	COG3850	Histidine kinase
HUW51_RS12810	COG3437	response regulator, receiver
HUW51_RS12810	COG2205	protein histidine kinase activity
HUW51_RS12815	COG2198	Histidine kinase
HUW51_RS12815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW51_RS12815	COG0784	Response regulator, receiver
HUW51_RS12815	COG2205	protein histidine kinase activity
HUW51_RS12820	COG2323	membrane
HUW51_RS12845	COG1027	Aspartate ammonia-lyase
HUW51_RS12860	COG0367	asparagine synthase
HUW51_RS12885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUW51_RS12900	COG0589	response to stress
HUW51_RS12900	COG0475	glutathione-regulated potassium exporter activity
HUW51_RS12925	COG0673	inositol 2-dehydrogenase activity
HUW51_RS12930	COG1082	Xylose isomerase domain protein TIM barrel
HUW51_RS12960	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HUW51_RS12960	COG0321	lipoyl(octanoyl) transferase activity
HUW51_RS12970	COG5002	protein histidine kinase activity
HUW51_RS12970	COG2198	Histidine kinase
HUW51_RS12970	COG0784	Response regulator, receiver
HUW51_RS12980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUW51_RS12985	COG0205	6-phosphofructokinase activity
HUW51_RS12995	COG0471	metal ion transport
HUW51_RS12995	COG3273	potassium ion transport
HUW51_RS13015	COG1595	DNA-templated transcription, initiation
HUW51_RS13020	COG3958	Transketolase
HUW51_RS13025	COG2304	oxidoreductase activity
HUW51_RS13030	COG3959	Transketolase, thiamine diphosphate binding domain
HUW51_RS13035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUW51_RS13045	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUW51_RS13060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUW51_RS13065	COG0305	Participates in initiation and elongation during chromosome replication
HUW51_RS13070	COG4771	TonB-dependent receptor
HUW51_RS13075	COG0702	epimerase
HUW51_RS13105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW51_RS13120	COG0288	reversible hydration of carbon dioxide
HUW51_RS13130	COG1011	Hydrolase
HUW51_RS13150	COG0596	Alpha beta hydrolase
HUW51_RS13185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUW51_RS13200	COG0784	Response regulator, receiver
HUW51_RS13205	COG4191	Histidine kinase
HUW51_RS13215	COG1506	peptidase
HUW51_RS13215	COG0823	Involved in the tonB-independent uptake of proteins
HUW51_RS13235	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HUW51_RS13240	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS13255	COG3278	Belongs to the heme-copper respiratory oxidase family
HUW51_RS13290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUW51_RS13295	COG0246	Mannitol dehydrogenase
HUW51_RS13300	COG1904	glucuronate isomerase
HUW51_RS13335	COG1733	regulation of RNA biosynthetic process
HUW51_RS13340	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS13345	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS13385	COG3119	arylsulfatase activity
HUW51_RS13405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUW51_RS13410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUW51_RS13420	COG3590	peptidase
HUW51_RS13430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUW51_RS13470	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUW51_RS13475	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS13485	COG4771	TonB-dependent receptor
HUW51_RS13495	COG4771	TonB-dependent receptor
HUW51_RS13505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUW51_RS13515	COG1136	(ABC) transporter
HUW51_RS13525	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUW51_RS13530	COG0204	Acyl-transferase
HUW51_RS13530	COG0318	PFAM AMP-dependent synthetase and ligase
HUW51_RS13550	COG1129	ABC transporter
HUW51_RS13555	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUW51_RS13570	COG0513	Belongs to the DEAD box helicase family
HUW51_RS13625	COG1054	Belongs to the UPF0176 family
HUW51_RS13630	COG0813	purine-nucleoside phosphorylase activity
HUW51_RS13645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUW51_RS13655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUW51_RS13665	COG3853	Toxic anion resistance protein (TelA)
HUW51_RS13690	COG0667	Aldo Keto reductase
HUW51_RS13715	COG0667	Aldo Keto reductase
HUW51_RS13760	COG2814	Major facilitator Superfamily
HUW51_RS13820	COG4654	Cytochrome c, class I
HUW51_RS13825	COG1733	regulation of RNA biosynthetic process
HUW51_RS13860	COG2308	Evidence 4 Homologs of previously reported genes of
HUW51_RS13900	COG2200	EAL domain
HUW51_RS13950	COG2197	response regulator
HUW51_RS13955	COG2017	converts alpha-aldose to the beta-anomer
HUW51_RS13965	COG0477	Major facilitator Superfamily
HUW51_RS13965	COG2814	Major facilitator Superfamily
HUW51_RS13970	COG0457	Tetratricopeptide repeat
HUW51_RS13975	COG1064	alcohol dehydrogenase
HUW51_RS13985	COG3263	regulation of cellular component size
HUW51_RS13990	COG2201	protein-glutamate methylesterase activity
HUW51_RS14035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUW51_RS14040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUW51_RS14050	COG0387	Pfam Sodium calcium exchanger
HUW51_RS14055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUW51_RS14065	COG2204	response regulator
HUW51_RS14070	COG5002	protein histidine kinase activity
HUW51_RS14075	COG2205	protein histidine kinase activity
HUW51_RS14085	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HUW51_RS14090	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HUW51_RS14095	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HUW51_RS14115	COG0791	NLP P60 protein
HUW51_RS14120	COG0367	asparagine synthase
HUW51_RS14130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW51_RS14135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW51_RS14140	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW51_RS14150	COG2089	acid synthase
HUW51_RS14155	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUW51_RS14160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUW51_RS14160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW51_RS14170	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUW51_RS14175	COG1083	cytidylyl-transferase
HUW51_RS14210	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUW51_RS14250	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HUW51_RS14260	COG0563	adenylate kinase activity
HUW51_RS14265	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUW51_RS14270	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUW51_RS14275	COG0484	heat shock protein binding
HUW51_RS14280	COG4152	abc transporter atp-binding protein
HUW51_RS14290	COG3781	membrane
HUW51_RS14310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUW51_RS14325	COG0438	transferase activity, transferring glycosyl groups
HUW51_RS14330	COG1472	Belongs to the glycosyl hydrolase 3 family
HUW51_RS14335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HUW51_RS14360	COG0175	sulfate reduction
HUW51_RS14365	COG0529	Catalyzes the synthesis of activated sulfate
HUW51_RS14370	COG1218	3'(2'),5'-bisphosphate nucleotidase
HUW51_RS14380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUW51_RS14390	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HUW51_RS14400	COG0175	sulfate reduction
HUW51_RS14405	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUW51_RS14410	COG0697	spore germination
HUW51_RS14425	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HUW51_RS14430	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUW51_RS14435	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUW51_RS14460	COG0189	ligase activity
HUW51_RS14460	COG4067	protein conserved in archaea
HUW51_RS14475	COG4585	Histidine kinase
HUW51_RS14480	COG2197	response regulator
HUW51_RS14485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUW51_RS14520	COG3292	Two component regulator propeller
HUW51_RS14520	COG2205	protein histidine kinase activity
HUW51_RS14520	COG0745	RESPONSE REGULATOR receiver
HUW51_RS14525	COG2996	Protein conserved in bacteria
HUW51_RS14580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUW51_RS14585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUW51_RS14590	COG0052	Belongs to the universal ribosomal protein uS2 family
HUW51_RS14595	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUW51_RS14610	COG0714	Associated with various cellular activities
HUW51_RS14615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUW51_RS14620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUW51_RS14640	COG0516	GMP reductase activity
HUW51_RS14640	COG0517	IMP dehydrogenase activity
HUW51_RS14645	COG1472	Belongs to the glycosyl hydrolase 3 family
HUW51_RS14675	COG1725	Transcriptional regulator
HUW51_RS14685	COG1131	(ABC) transporter
HUW51_RS14690	COG0247	lactate metabolic process
HUW51_RS14690	COG0277	FAD linked oxidase domain protein
HUW51_RS14725	COG2814	Major facilitator Superfamily
HUW51_RS14740	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS14745	COG2706	6-phosphogluconolactonase activity
HUW51_RS14750	COG0604	alcohol dehydrogenase
HUW51_RS14750	COG3321	synthase
HUW51_RS14750	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS14780	COG3781	membrane
HUW51_RS14790	COG1204	response to ionizing radiation
HUW51_RS14800	COG0667	Aldo Keto reductase
HUW51_RS14805	COG0667	Aldo Keto reductase
HUW51_RS14815	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HUW51_RS14820	COG1984	allophanate hydrolase subunit 2
HUW51_RS14825	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HUW51_RS14830	COG1914	H( )-stimulated, divalent metal cation uptake system
HUW51_RS14845	COG0193	aminoacyl-tRNA hydrolase activity
HUW51_RS14850	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUW51_RS14855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUW51_RS14865	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUW51_RS14875	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUW51_RS14880	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUW51_RS14905	COG0628	permease
HUW51_RS14910	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW51_RS14915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW51_RS14930	COG1278	Cold shock
HUW51_RS14935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUW51_RS14955	COG1187	pseudouridine synthase activity
HUW51_RS15005	COG1733	regulation of RNA biosynthetic process
HUW51_RS15020	COG0405	Gamma-glutamyltransferase
HUW51_RS15035	COG1073	alpha beta
HUW51_RS15050	COG2271	Major facilitator Superfamily
HUW51_RS15100	COG2169	Transcriptional regulator
HUW51_RS15105	COG0673	inositol 2-dehydrogenase activity
HUW51_RS15150	COG1733	regulation of RNA biosynthetic process
HUW51_RS15165	COG3023	N-Acetylmuramoyl-L-alanine amidase
HUW51_RS15170	COG2354	Protein conserved in bacteria
HUW51_RS15185	COG0668	transmembrane transport
HUW51_RS15195	COG1621	beta-fructofuranosidase activity
HUW51_RS15200	COG5002	protein histidine kinase activity
HUW51_RS15270	COG2010	Cytochrome c
HUW51_RS15270	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUW51_RS15275	COG2080	2 iron, 2 sulfur cluster binding
HUW51_RS15285	COG0038	chloride channel
HUW51_RS15310	COG1090	epimerase
HUW51_RS15335	COG3237	CsbD-like
HUW51_RS15340	COG1741	Belongs to the pirin family
HUW51_RS15350	COG1131	(ABC) transporter
HUW51_RS15370	COG2721	sulfolactate sulfo-lyase activity
HUW51_RS15390	COG0673	inositol 2-dehydrogenase activity
HUW51_RS15400	COG1858	cytochrome C peroxidase
HUW51_RS15415	COG1858	cytochrome C peroxidase
HUW51_RS15430	COG1999	signal sequence binding
HUW51_RS15455	COG1070	Carbohydrate kinase
HUW51_RS15465	COG0745	RESPONSE REGULATOR receiver
HUW51_RS15470	COG5002	protein histidine kinase activity
HUW51_RS15480	COG0288	reversible hydration of carbon dioxide
HUW51_RS15530	COG1012	belongs to the aldehyde dehydrogenase family
HUW51_RS15575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUW51_RS15585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUW51_RS15590	COG1363	Peptidase, m42
HUW51_RS15595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUW51_RS15600	COG0542	response to heat
HUW51_RS15615	COG0009	L-threonylcarbamoyladenylate synthase
HUW51_RS15620	COG0784	Response regulator, receiver
HUW51_RS15620	COG2205	protein histidine kinase activity
HUW51_RS15630	COG0824	Thioesterase
HUW51_RS15645	COG1464	Belongs to the NlpA lipoprotein family
HUW51_RS15650	COG2011	ABC-type metal ion transport system permease component
HUW51_RS15660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUW51_RS15680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUW51_RS15720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUW51_RS15725	COG1309	transcriptional regulator
HUW51_RS15745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUW51_RS15785	COG0693	protein deglycase activity
HUW51_RS15800	COG0673	inositol 2-dehydrogenase activity
HUW51_RS15820	COG0628	permease
HUW51_RS15830	COG0028	Belongs to the TPP enzyme family
HUW51_RS15845	COG0123	including yeast histone deacetylase and acetoin utilization protein
HUW51_RS15870	COG1609	Transcriptional regulator
HUW51_RS15895	COG0681	Belongs to the peptidase S26 family
HUW51_RS15900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUW51_RS15910	COG3842	ATPase activity
HUW51_RS15915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUW51_RS15945	COG2885	chlorophyll binding
HUW51_RS15960	COG1629	transport
HUW51_RS15985	COG0129	dihydroxy-acid dehydratase activity
HUW51_RS15990	COG2610	gluconate transmembrane transporter activity
HUW51_RS16000	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW51_RS16005	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW51_RS16040	COG0415	Belongs to the DNA photolyase family
HUW51_RS16045	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS16065	COG2086	electron transfer activity
HUW51_RS16070	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HUW51_RS16085	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUW51_RS16090	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS16095	COG1131	(ABC) transporter
HUW51_RS16130	COG0717	Belongs to the dCTP deaminase family
HUW51_RS16135	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUW51_RS16145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUW51_RS16145	COG0519	Catalyzes the synthesis of GMP from XMP
HUW51_RS16150	COG5002	protein histidine kinase activity
HUW51_RS16165	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUW51_RS16175	COG2884	Cell division ATP-binding protein ftsE
HUW51_RS16210	COG2089	acid synthase
HUW51_RS16220	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HUW51_RS16225	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW51_RS16230	COG1086	Polysaccharide biosynthesis protein
HUW51_RS16245	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HUW51_RS16250	COG0590	tRNA wobble adenosine to inosine editing
HUW51_RS16285	COG1309	transcriptional regulator
HUW51_RS16320	COG4771	TonB-dependent receptor
HUW51_RS16375	COG1253	flavin adenine dinucleotide binding
HUW51_RS16410	COG1132	(ABC) transporter
HUW51_RS16440	COG0784	Response regulator, receiver
HUW51_RS16440	COG2198	Histidine kinase
HUW51_RS16440	COG0643	Histidine kinase
HUW51_RS16465	COG2353	YceI-like domain
HUW51_RS16520	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUW51_RS16540	COG1960	acyl-CoA dehydrogenase activity
HUW51_RS16550	COG2255	four-way junction helicase activity
HUW51_RS16555	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HUW51_RS16600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUW51_RS16610	COG0572	uridine kinase
HUW51_RS16620	COG1702	phosphate starvation-inducible protein PhoH
HUW51_RS16630	COG0658	competence protein
HUW51_RS16630	COG2333	competence protein COMEC
HUW51_RS16650	COG1595	DNA-templated transcription, initiation
HUW51_RS16675	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUW51_RS16700	COG2001	Belongs to the MraZ family
HUW51_RS16705	COG0275	rRNA processing
HUW51_RS16715	COG0768	penicillin binding
HUW51_RS16720	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUW51_RS16725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUW51_RS16730	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUW51_RS16735	COG0772	Belongs to the SEDS family
HUW51_RS16740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUW51_RS16745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUW51_RS16760	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUW51_RS16770	COG0531	amino acid
HUW51_RS16780	COG1764	response to oxidative stress
HUW51_RS16785	COG0045	succinate-CoA ligase (ADP-forming) activity
HUW51_RS16795	COG1136	(ABC) transporter
HUW51_RS16825	COG4251	negative regulation of phosphorylation
HUW51_RS16855	COG3781	membrane
HUW51_RS16865	COG2610	gluconate transmembrane transporter activity
HUW51_RS16885	COG2255	four-way junction helicase activity
HUW51_RS16995	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HUW51_RS17070	COG0616	signal peptide processing
HUW51_RS17205	COG1132	(ABC) transporter
HUW51_RS17215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUW51_RS17225	COG0473	3-isopropylmalate dehydrogenase activity
HUW51_RS17235	COG1862	Preprotein translocase
HUW51_RS17245	COG0237	dephospho-CoA kinase activity
HUW51_RS17250	COG1312	Catalyzes the dehydration of D-mannonate
HUW51_RS17255	COG3661	Belongs to the glycosyl hydrolase 67 family
HUW51_RS17265	COG2814	Major facilitator Superfamily
HUW51_RS17290	COG1309	transcriptional regulator
HUW51_RS17295	COG2133	pyrroloquinoline quinone binding
HUW51_RS17300	COG1940	carbohydrate kinase activity
HUW51_RS17305	COG2353	YceI-like domain
HUW51_RS17310	COG0346	lactoylglutathione lyase activity
HUW51_RS17335	COG3279	Response regulator of the LytR AlgR family
HUW51_RS17340	COG3275	phosphorelay sensor kinase activity
HUW51_RS17395	COG3621	Patatin-like phospholipase
HUW51_RS17425	COG3547	Transposase (IS116 IS110 IS902 family)
HUW51_RS17435	COG4771	TonB-dependent receptor
HUW51_RS17530	COG0247	lactate metabolic process
HUW51_RS17535	COG1139	Iron-sulfur cluster binding protein
HUW51_RS17540	COG1556	Lactate utilization protein
HUW51_RS17595	COG0745	RESPONSE REGULATOR receiver
HUW51_RS17595	COG2205	protein histidine kinase activity
HUW51_RS17595	COG3292	Two component regulator propeller
HUW51_RS17605	COG0784	Response regulator, receiver
HUW51_RS17605	COG4191	Histidine kinase
HUW51_RS17615	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HUW51_RS17635	COG0431	NADPH-dependent FMN reductase
HUW51_RS17640	COG2151	metal-sulfur cluster biosynthetic enzyme
HUW51_RS17645	COG2166	iron-sulfur cluster assembly
HUW51_RS17655	COG0719	Fe-S assembly protein
HUW51_RS17660	COG0396	ATPase activity
HUW51_RS17665	COG0719	Fe-S assembly protein
HUW51_RS17670	COG0316	Belongs to the HesB IscA family
HUW51_RS17680	COG0633	Ferredoxin
HUW51_RS17685	COG0492	ferredoxin-NADP+ reductase activity
HUW51_RS17705	COG1131	(ABC) transporter
HUW51_RS17730	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUW51_RS17760	COG0346	lactoylglutathione lyase activity
HUW51_RS17765	COG2195	Cleaves the N-terminal amino acid of tripeptides
HUW51_RS17770	COG2267	carboxylic ester hydrolase activity
HUW51_RS17800	COG1733	regulation of RNA biosynthetic process
HUW51_RS17845	COG0673	inositol 2-dehydrogenase activity
HUW51_RS17865	COG0702	epimerase
HUW51_RS17870	COG4771	TonB-dependent receptor
HUW51_RS17880	COG4952	isomerase
HUW51_RS17885	COG3347	Dehydrogenase
HUW51_RS17885	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS17900	COG1609	Transcriptional regulator
HUW51_RS17905	COG4771	TonB-dependent receptor
HUW51_RS17920	COG4206	TonB-dependent receptor
HUW51_RS17920	COG1629	transport
HUW51_RS17940	COG1446	asparaginase
HUW51_RS17965	COG0318	PFAM AMP-dependent synthetase and ligase
HUW51_RS17970	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HUW51_RS17985	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HUW51_RS17990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUW51_RS18000	COG0406	alpha-ribazole phosphatase activity
HUW51_RS18020	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HUW51_RS18045	COG0488	(ABC) transporter
HUW51_RS18060	COG0346	lactoylglutathione lyase activity
HUW51_RS18070	COG0012	GTP binding
HUW51_RS18090	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HUW51_RS18110	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUW51_RS18120	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUW51_RS18130	COG2816	NAD+ diphosphatase activity
HUW51_RS18135	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUW51_RS18145	COG2363	Small membrane protein
HUW51_RS18150	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HUW51_RS18175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW51_RS18180	COG0723	plastoquinol--plastocyanin reductase activity
HUW51_RS18180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUW51_RS18190	COG0534	Mate efflux family protein
HUW51_RS18195	COG0436	Aminotransferase
HUW51_RS18200	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HUW51_RS18205	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUW51_RS18215	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUW51_RS18240	COG0835	chemotaxis
HUW51_RS18245	COG2201	protein-glutamate methylesterase activity
HUW51_RS18250	COG2198	Histidine kinase
HUW51_RS18250	COG0643	Histidine kinase
HUW51_RS18255	COG1776	CheC inhibitor of MCP methylation
HUW51_RS18260	COG0010	Belongs to the arginase family
HUW51_RS18275	COG0514	ATP-dependent DNA helicase (RecQ)
HUW51_RS18285	COG1741	Belongs to the pirin family
HUW51_RS18310	COG1652	LysM domain
HUW51_RS18315	COG2887	Belongs to the helicase family. UvrD subfamily
HUW51_RS18340	COG1074	ATP-dependent DNA helicase activity
HUW51_RS18345	COG0513	Belongs to the DEAD box helicase family
HUW51_RS18395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUW51_RS18410	COG0463	Glycosyl transferase, family 2
HUW51_RS18430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUW51_RS18440	COG0671	phosphoesterase, PA-phosphatase related
HUW51_RS18445	COG0671	phosphoesterase, PA-phosphatase related
HUW51_RS18460	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUW51_RS18495	COG0463	Glycosyl transferase, family 2
HUW51_RS18500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HUW51_RS18510	COG0010	Belongs to the arginase family
HUW51_RS18515	COG0018	arginyl-trna synthetase
HUW51_RS18520	COG0386	Belongs to the glutathione peroxidase family
HUW51_RS18525	COG1575	Belongs to the MenA family. Type 1 subfamily
HUW51_RS18530	COG0513	Belongs to the DEAD box helicase family
HUW51_RS18535	COG0217	transcriptional regulatory protein
HUW51_RS18545	COG0488	(ABC) transporter
HUW51_RS18555	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HUW51_RS18565	COG0754	glutathionylspermidine amidase activity
HUW51_RS18580	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUW51_RS18595	COG0713	ATP synthesis coupled electron transport
HUW51_RS18600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUW51_RS18610	COG1007	ATP synthesis coupled electron transport
HUW51_RS18615	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HUW51_RS18625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUW51_RS18625	COG1648	precorrin-2 dehydrogenase activity
HUW51_RS18630	COG0673	inositol 2-dehydrogenase activity
HUW51_RS18645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW51_RS18685	COG1215	transferase activity, transferring glycosyl groups
HUW51_RS18690	COG0084	hydrolase, TatD family'
HUW51_RS18695	COG0252	asparaginase activity
HUW51_RS18720	COG2814	Major facilitator Superfamily
HUW51_RS18750	COG0673	inositol 2-dehydrogenase activity
HUW51_RS18770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUW51_RS18790	COG4251	negative regulation of phosphorylation
HUW51_RS18795	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HUW51_RS18815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW51_RS18820	COG0673	inositol 2-dehydrogenase activity
HUW51_RS18850	COG3387	PFAM Glycoside hydrolase 15-related
HUW51_RS18865	COG0640	Transcriptional regulator
HUW51_RS18880	COG1187	pseudouridine synthase activity
HUW51_RS18885	COG0300	oxidoreductase activity
HUW51_RS18895	COG4771	TonB-dependent receptor
HUW51_RS18950	COG1222	aaa ATPase
HUW51_RS19125	COG5002	protein histidine kinase activity
HUW51_RS19130	COG3458	cephalosporin-C deacetylase activity
HUW51_RS19135	COG2205	protein histidine kinase activity
HUW51_RS19135	COG0784	Response regulator, receiver
HUW51_RS19135	COG5002	protein histidine kinase activity
HUW51_RS19140	COG1228	amidohydrolase
HUW51_RS19220	COG2076	Multidrug Resistance protein
HUW51_RS19230	COG2860	membrane
HUW51_RS19240	COG2755	lipolytic protein G-D-S-L family
HUW51_RS19240	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUW51_RS19255	COG2378	regulation of single-species biofilm formation
HUW51_RS19315	COG4771	TonB-dependent receptor
HUW51_RS19345	COG3546	catalase activity
HUW51_RS19355	COG0667	Aldo Keto reductase
HUW51_RS19390	COG0604	alcohol dehydrogenase
HUW51_RS19405	COG1278	Cold shock
HUW51_RS19450	COG0492	ferredoxin-NADP+ reductase activity
HUW51_RS19485	COG4771	TonB-dependent receptor
HUW51_RS19490	COG0702	epimerase
HUW51_RS19515	COG1609	Transcriptional regulator
HUW51_RS19530	COG0745	RESPONSE REGULATOR receiver
HUW51_RS19535	COG5002	protein histidine kinase activity
HUW51_RS19550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUW51_RS19565	COG2382	esterase
HUW51_RS19575	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW51_RS19600	COG0657	acetylesterase activity
HUW51_RS19600	COG2755	lipolytic protein G-D-S-L family
HUW51_RS19610	COG2382	esterase
HUW51_RS19615	COG2382	esterase
HUW51_RS19620	COG2382	esterase
HUW51_RS19625	COG2382	esterase
HUW51_RS19625	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW51_RS19625	COG3693	PFAM glycoside hydrolase, family 10
HUW51_RS19630	COG4993	Dehydrogenase
HUW51_RS19640	COG3386	PFAM SMP-30 Gluconolaconase
HUW51_RS19645	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HUW51_RS19665	COG3852	Histidine kinase
HUW51_RS19695	COG2217	Heavy metal translocating P-type atpase
HUW51_RS19720	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HUW51_RS19735	COG1321	iron dependent repressor
HUW51_RS19740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUW51_RS19750	COG2171	N-acyltransferase activity
HUW51_RS19755	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUW51_RS19775	COG0488	(ABC) transporter
HUW51_RS19800	COG1104	cysteine desulfurase activity
HUW51_RS19805	COG0346	lactoylglutathione lyase activity
HUW51_RS19820	COG0617	tRNA 3'-terminal CCA addition
HUW51_RS19835	COG1695	Transcriptional regulator
HUW51_RS19860	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUW51_RS19865	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUW51_RS19875	COG0668	transmembrane transport
HUW51_RS19885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUW51_RS19895	COG2197	response regulator
HUW51_RS19915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUW51_RS19930	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUW51_RS19955	COG3162	membrane
HUW51_RS19960	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUW51_RS19965	COG0784	Response regulator, receiver
HUW51_RS19970	COG4251	negative regulation of phosphorylation
HUW51_RS19975	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUW51_RS19980	COG2045	Belongs to the ComB family
HUW51_RS19985	COG1694	Mazg nucleotide pyrophosphohydrolase
HUW51_RS19990	COG1490	D-aminoacyl-tRNA deacylase activity
HUW51_RS20000	COG0598	Magnesium transport protein CorA
HUW51_RS20015	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUW51_RS20035	COG1216	Glycosyl transferase, family 2
HUW51_RS20075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUW51_RS20080	COG1162	GTPase activity
HUW51_RS20085	COG1519	Transferase
HUW51_RS20090	COG0527	aspartate kinase activity
HUW51_RS20105	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HUW51_RS20115	COG2226	methyltransferase
HUW51_RS20125	COG4221	oxidoreductase activity
HUW51_RS20140	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HUW51_RS20145	COG0328	RNA-DNA hybrid ribonuclease activity
HUW51_RS20150	COG2095	MarC family integral membrane protein
HUW51_RS20160	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUW51_RS20165	COG4974	Belongs to the 'phage' integrase family
HUW51_RS20190	COG0167	dihydroorotate dehydrogenase activity
HUW51_RS20195	COG1674	ftsk spoiiie
HUW51_RS20210	COG0277	FAD linked oxidase domain protein
HUW51_RS20210	COG0247	lactate metabolic process
HUW51_RS20220	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUW51_RS20225	COG0791	NLP P60 protein
HUW51_RS20235	COG0539	negative regulation of cytoplasmic translation
HUW51_RS20280	COG1063	alcohol dehydrogenase
HUW51_RS20285	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS20300	COG0673	inositol 2-dehydrogenase activity
HUW51_RS20310	COG0673	inositol 2-dehydrogenase activity
HUW51_RS20325	COG5002	protein histidine kinase activity
HUW51_RS20330	COG0165	Argininosuccinate lyase
HUW51_RS20345	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUW51_RS20350	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUW51_RS20355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUW51_RS20360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUW51_RS20365	COG0137	argininosuccinate synthase activity
HUW51_RS20375	COG0287	Prephenate dehydrogenase
HUW51_RS20385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUW51_RS20440	COG0463	Glycosyl transferase, family 2
HUW51_RS20450	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HUW51_RS20470	COG2814	Major facilitator Superfamily
HUW51_RS20480	COG3239	Fatty acid desaturase
HUW51_RS20485	COG0673	inositol 2-dehydrogenase activity
HUW51_RS20510	COG1216	Glycosyl transferase, family 2
HUW51_RS20525	COG0463	Glycosyl transferase, family 2
HUW51_RS20525	COG1216	Glycosyl transferase, family 2
HUW51_RS20555	COG0438	transferase activity, transferring glycosyl groups
HUW51_RS20565	COG0022	dehydrogenase e1 component
HUW51_RS20565	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUW51_RS20580	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUW51_RS20600	COG0124	histidyl-tRNA synthetase
HUW51_RS20605	COG3153	acetyltransferase
HUW51_RS20605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUW51_RS20620	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HUW51_RS20625	COG0196	riboflavin kinase activity
HUW51_RS20630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUW51_RS20635	COG1968	undecaprenyl-diphosphatase activity
HUW51_RS20645	COG2177	Part of the ABC transporter FtsEX involved in
HUW51_RS20655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUW51_RS20670	COG0439	Biotin carboxylase
HUW51_RS20680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUW51_RS20685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUW51_RS20690	COG0416	fatty acid biosynthetic process
HUW51_RS20695	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUW51_RS20705	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HUW51_RS20710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUW51_RS20715	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUW51_RS20720	COG2239	Acts as a magnesium transporter
HUW51_RS20725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUW51_RS20730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUW51_RS20735	COG0537	adenosine 5'-monophosphoramidase activity
HUW51_RS20740	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HUW51_RS20795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUW51_RS20795	COG1199	ATP-dependent helicase activity
HUW51_RS20800	COG0628	permease
HUW51_RS20825	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUW51_RS20830	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUW51_RS20835	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUW51_RS20840	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUW51_RS20860	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUW51_RS20865	COG1185	polyribonucleotide nucleotidyltransferase activity
HUW51_RS20870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUW51_RS20875	COG0492	ferredoxin-NADP+ reductase activity
HUW51_RS20880	COG0739	heme binding
HUW51_RS20890	COG0439	Biotin carboxylase
HUW51_RS20905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUW51_RS20930	COG0811	peptide transport
HUW51_RS20935	COG0848	biopolymer transport protein
HUW51_RS20950	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUW51_RS20955	COG0135	phosphoribosylanthranilate isomerase activity
HUW51_RS20960	COG0482	sulfurtransferase activity
HUW51_RS20975	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUW51_RS20990	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUW51_RS20995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUW51_RS21000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUW51_RS21005	COG0131	Imidazoleglycerol-phosphate dehydratase
HUW51_RS21005	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HUW51_RS21010	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUW51_RS21015	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUW51_RS21020	COG0107	imidazoleglycerol-phosphate synthase activity
HUW51_RS21025	COG0140	phosphoribosyl-ATP diphosphatase activity
HUW51_RS21025	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUW51_RS21030	COG1309	transcriptional regulator
HUW51_RS21035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW51_RS21040	COG4771	TonB-dependent receptor
HUW51_RS21050	COG2814	Major facilitator Superfamily
HUW51_RS21060	COG0673	inositol 2-dehydrogenase activity
HUW51_RS21090	COG2081	HI0933 family
HUW51_RS21100	COG3339	Conserved Protein
HUW51_RS21115	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HUW51_RS21145	COG1446	asparaginase
HUW51_RS21155	COG3685	Protein conserved in bacteria
HUW51_RS21180	COG1570	exodeoxyribonuclease VII activity
HUW51_RS21185	COG1722	exodeoxyribonuclease VII activity
HUW51_RS21195	COG3279	Response regulator of the LytR AlgR family
HUW51_RS21200	COG3275	phosphorelay sensor kinase activity
HUW51_RS21225	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUW51_RS21235	COG2197	response regulator
HUW51_RS21240	COG4585	Histidine kinase
HUW51_RS21265	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS21290	COG1678	Uncharacterized ACR, COG1678
HUW51_RS21305	COG0424	maF-like protein
HUW51_RS21310	COG0667	Aldo Keto reductase
HUW51_RS21320	COG3483	tryptophan 2,3-dioxygenase activity
HUW51_RS21325	COG1760	l-serine dehydratase
HUW51_RS21340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUW51_RS21370	COG1538	Outer membrane efflux protein
HUW51_RS21380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUW51_RS21400	COG0300	oxidoreductase activity
HUW51_RS21405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUW51_RS21425	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HUW51_RS21430	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HUW51_RS21465	COG0504	CTP synthase activity
HUW51_RS21470	COG0706	membrane insertase activity
HUW51_RS21475	COG0747	negative chemotaxis
HUW51_RS21480	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUW51_RS21485	COG1192	Involved in chromosome partitioning
HUW51_RS21490	COG1475	DNA binding
HUW51_RS21500	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUW51_RS21505	COG0681	Belongs to the peptidase S26 family
HUW51_RS21510	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUW51_RS21525	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HUW51_RS21535	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUW51_RS21535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUW51_RS21545	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HUW51_RS21570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUW51_RS21585	COG0408	coproporphyrinogen oxidase activity
HUW51_RS21600	COG0671	phosphoesterase, PA-phosphatase related
HUW51_RS21625	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUW51_RS21630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUW51_RS21635	COG1607	acyl-coa hydrolase
HUW51_RS21645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUW51_RS21650	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUW51_RS21655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUW51_RS21670	COG0758	DNA mediated transformation
HUW51_RS21680	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUW51_RS21705	COG2223	nitrite transmembrane transporter activity
HUW51_RS21710	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HUW51_RS21730	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HUW51_RS21735	COG1047	Peptidyl-prolyl cis-trans
HUW51_RS21740	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HUW51_RS21785	COG0495	leucyl-tRNA aminoacylation
HUW51_RS21795	COG0156	8-amino-7-oxononanoate synthase activity
HUW51_RS21805	COG2315	Protein conserved in bacteria
HUW51_RS21810	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUW51_RS21830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUW51_RS21840	COG1119	ATPase activity
HUW51_RS21860	COG0577	efflux transmembrane transporter activity
HUW51_RS21860	COG1136	(ABC) transporter
HUW51_RS21880	COG1663	tetraacyldisaccharide 4'-kinase activity
HUW51_RS21885	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUW51_RS21900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUW51_RS21905	COG3604	Transcriptional regulator
HUW51_RS21925	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUW51_RS21930	COG0459	protein refolding
HUW51_RS21940	COG3104	oligopeptide transport
HUW51_RS21945	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUW51_RS21960	COG1196	nuclear chromosome segregation
HUW51_RS21975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUW51_RS21980	COG0825	malonyl-CoA metabolic process
HUW51_RS22010	COG1115	amino acid carrier protein
HUW51_RS22025	COG4134	Bacterial extracellular solute-binding protein
HUW51_RS22040	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HUW51_RS22050	COG0659	secondary active sulfate transmembrane transporter activity
HUW51_RS22060	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUW51_RS22060	COG4651	solute:proton antiporter activity
HUW51_RS22065	COG4585	Histidine kinase
HUW51_RS22120	COG4302	ethanolamine ammonia-lyase activity
HUW51_RS22125	COG4303	Ethanolamine ammonia lyase large subunit
HUW51_RS22130	COG0531	amino acid
HUW51_RS22150	COG0517	IMP dehydrogenase activity
HUW51_RS22150	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HUW51_RS22155	COG0662	Cupin 2, conserved barrel domain protein
HUW51_RS22155	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HUW51_RS22170	COG1981	membrane
HUW51_RS22185	COG1515	deoxyribonuclease V activity
HUW51_RS22195	COG0300	oxidoreductase activity
HUW51_RS22200	COG0300	oxidoreductase activity
HUW51_RS22210	COG0542	response to heat
HUW51_RS22215	COG1187	pseudouridine synthase activity
HUW51_RS22220	COG0443	Heat shock 70 kDa protein
HUW51_RS22230	COG2197	response regulator
HUW51_RS22245	COG4585	Histidine kinase
HUW51_RS22310	COG1214	PFAM Peptidase M22, glycoprotease
HUW51_RS22315	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HUW51_RS22330	COG0829	nickel cation binding
HUW51_RS22335	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HUW51_RS22340	COG0830	nickel cation binding
HUW51_RS22345	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HUW51_RS22350	COG0804	urea catabolic process
HUW51_RS22355	COG0832	Belongs to the urease beta subunit family
HUW51_RS22360	COG0831	urea catabolic process
HUW51_RS22375	COG2176	DNA-directed DNA polymerase activity
HUW51_RS22400	COG0363	glucosamine-6-phosphate deaminase activity
HUW51_RS22405	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HUW51_RS22410	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUW51_RS22420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUW51_RS22425	COG0698	ribose 5-phosphate isomerase
HUW51_RS22435	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS22445	COG2814	Major facilitator Superfamily
HUW51_RS22450	COG0667	Aldo Keto reductase
HUW51_RS22470	COG4251	negative regulation of phosphorylation
HUW51_RS22495	COG0339	signal peptide processing
HUW51_RS22530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUW51_RS22540	COG1215	transferase activity, transferring glycosyl groups
HUW51_RS22580	COG3781	membrane
HUW51_RS22585	COG2080	2 iron, 2 sulfur cluster binding
HUW51_RS22590	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUW51_RS22595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUW51_RS22610	COG4771	TonB-dependent receptor
HUW51_RS22620	COG0251	oxidation-reduction process
HUW51_RS22650	COG1629	transport
HUW51_RS22665	COG0402	S-adenosylhomocysteine deaminase activity
HUW51_RS22675	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUW51_RS22695	COG3254	rhamnose metabolic process
HUW51_RS22700	COG1725	Transcriptional regulator
HUW51_RS22725	COG5002	protein histidine kinase activity
HUW51_RS22730	COG0745	RESPONSE REGULATOR receiver
HUW51_RS22735	COG0673	inositol 2-dehydrogenase activity
HUW51_RS22745	COG1266	CAAX protease self-immunity
HUW51_RS22750	COG4589	Belongs to the CDS family
HUW51_RS22755	COG0688	phosphatidylethanolamine metabolic process
HUW51_RS22760	COG1956	GAF domain-containing protein
HUW51_RS22765	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUW51_RS22765	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUW51_RS22770	COG2890	protein-(glutamine-N5) methyltransferase activity
HUW51_RS22785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUW51_RS22795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUW51_RS22800	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HUW51_RS22805	COG1228	amidohydrolase
HUW51_RS22815	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUW51_RS22820	COG0656	L-ascorbic acid biosynthetic process
HUW51_RS22845	COG2226	methyltransferase
HUW51_RS22855	COG5002	protein histidine kinase activity
HUW51_RS22910	COG2304	oxidoreductase activity
HUW51_RS22920	COG0183	Belongs to the thiolase family
HUW51_RS22930	COG0116	Belongs to the methyltransferase superfamily
HUW51_RS22935	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUW51_RS22940	COG1193	negative regulation of DNA recombination
HUW51_RS22980	COG0673	inositol 2-dehydrogenase activity
HUW51_RS22985	COG0438	transferase activity, transferring glycosyl groups
HUW51_RS23005	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUW51_RS23015	COG0022	dehydrogenase e1 component
HUW51_RS23045	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HUW51_RS23050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUW51_RS23055	COG2270	Major facilitator Superfamily
HUW51_RS23075	COG1690	Belongs to the RtcB family
HUW51_RS23115	COG2160	L-arabinose isomerase activity
HUW51_RS23175	COG1929	Belongs to the glycerate kinase type-1 family
HUW51_RS23180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUW51_RS23190	COG0579	oxidoreductase
HUW51_RS23240	COG0602	queuosine metabolic process
HUW51_RS23245	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUW51_RS23250	COG0481	GTPase activity
HUW51_RS23255	COG5002	protein histidine kinase activity
HUW51_RS23260	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW51_RS23260	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUW51_RS23260	COG1703	isobutyryl-CoA mutase activity
HUW51_RS23270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUW51_RS23290	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUW51_RS23295	COG0126	phosphoglycerate kinase activity
HUW51_RS23330	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUW51_RS23330	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUW51_RS23345	COG0358	DNA primase activity
HUW51_RS23375	COG0489	protein tyrosine kinase activity
HUW51_RS23380	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HUW51_RS23380	COG0316	Belongs to the HesB IscA family
HUW51_RS23390	COG1335	isochorismatase
HUW51_RS23400	COG0514	ATP-dependent DNA helicase (RecQ)
HUW51_RS23405	COG0154	amidase activity
HUW51_RS23420	COG0730	response to heat
HUW51_RS23440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUW51_RS23455	COG1028	Short-chain dehydrogenase reductase Sdr
HUW51_RS23465	COG2271	Major facilitator Superfamily
HUW51_RS23485	COG0673	inositol 2-dehydrogenase activity
HUW51_RS23505	COG0739	heme binding
HUW51_RS23540	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUW51_RS23545	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HUW51_RS23550	COG2095	MarC family integral membrane protein
HUW51_RS23555	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUW51_RS23560	COG2912	Transglutaminase-like superfamily
HUW51_RS23565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUW51_RS23575	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUW51_RS23585	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUW51_RS23590	COG0564	pseudouridine synthase activity
HUW51_RS23605	COG0228	four-way junction DNA binding
HUW51_RS23610	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUW51_RS23615	COG0336	Belongs to the RNA methyltransferase TrmD family
HUW51_RS23620	COG0335	large ribosomal subunit rRNA binding
HUW51_RS23645	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUW51_RS23650	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HUW51_RS23655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUW51_RS23655	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUW51_RS23660	COG0571	ribonuclease III activity
HUW51_RS23665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUW51_RS23670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUW51_RS23680	COG0469	pyruvate kinase activity
HUW51_RS23685	COG0268	Binds directly to 16S ribosomal RNA
HUW51_RS23690	COG0429	hydrolase of the alpha beta-hydrolase fold
HUW51_RS23700	COG0366	Alpha amylase catalytic
HUW51_RS23710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUW51_RS23725	COG1289	transmembrane transporter activity
HUW51_RS23740	COG0697	spore germination
HUW51_RS23760	COG3386	PFAM SMP-30 Gluconolaconase
HUW51_RS23770	COG0745	RESPONSE REGULATOR receiver
HUW51_RS23780	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HUW51_RS23785	COG0783	Belongs to the Dps family
HUW51_RS23810	COG0598	Magnesium transport protein CorA
HUW51_RS23815	COG0531	amino acid
HUW51_RS23830	COG2226	methyltransferase
HUW51_RS23845	COG3546	catalase activity
HUW51_RS23855	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUW51_RS23860	COG0673	inositol 2-dehydrogenase activity
HUW51_RS23890	COG0667	Aldo Keto reductase
HUW51_RS23905	COG1643	Atp-dependent helicase
HUW51_RS23930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUW51_RS23935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HUW51_RS23940	COG0156	8-amino-7-oxononanoate synthase activity
HUW51_RS23945	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HUW51_RS23950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUW51_RS23955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUW51_RS23965	COG0527	aspartate kinase activity
HUW51_RS23970	COG0019	diaminopimelate decarboxylase activity
HUW51_RS23990	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUW51_RS24000	COG1234	tRNA 3'-trailer cleavage
HUW51_RS24010	COG0180	Tryptophanyl-tRNA synthetase
HUW51_RS24015	COG4948	Mandelate Racemase Muconate Lactonizing
HUW51_RS24025	COG0473	3-isopropylmalate dehydrogenase activity
HUW51_RS24025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUW51_RS24040	COG4948	Mandelate Racemase Muconate Lactonizing
HUW51_RS24045	COG4948	Mandelate Racemase Muconate Lactonizing
HUW51_RS24060	COG1629	transport
HUW51_RS24060	COG4206	TonB-dependent receptor
HUW51_RS24070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUW51_RS24075	COG2226	methyltransferase
HUW51_RS24090	COG0587	DNA-directed DNA polymerase activity
HUW51_RS24100	COG1396	sequence-specific DNA binding
HUW51_RS24105	COG2135	peptidase activity
HUW51_RS24130	COG5002	protein histidine kinase activity
HUW51_RS24155	COG2936	dipeptidyl-peptidase activity
HUW51_RS24170	COG3119	arylsulfatase activity
HUW51_RS24175	COG3119	arylsulfatase activity
HUW51_RS24190	COG1629	transport
HUW51_RS24195	COG0702	epimerase
HUW51_RS24205	COG2211	Major facilitator Superfamily
HUW51_RS24215	COG0673	inositol 2-dehydrogenase activity
HUW51_RS24250	COG0745	RESPONSE REGULATOR receiver
HUW51_RS24250	COG2205	protein histidine kinase activity
HUW51_RS24250	COG3292	Two component regulator propeller
HUW51_RS24270	COG3291	Pkd domain containing protein
HUW51_RS24280	COG0561	phosphatase activity
HUW51_RS24285	COG4771	TonB-dependent receptor
HUW51_RS24295	COG3387	PFAM Glycoside hydrolase 15-related
HUW51_RS24300	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HUW51_RS24305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUW51_RS24310	COG0405	Gamma-glutamyltransferase
HUW51_RS24315	COG4953	penicillin-binding protein 1C
HUW51_RS24330	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUW51_RS24335	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUW51_RS24370	COG3530	Putative quorum-sensing-regulated virulence factor
HUW51_RS24385	COG0628	permease
HUW51_RS24390	COG0484	heat shock protein binding
HUW51_RS24405	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUW51_RS24405	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUW51_RS24420	COG1309	transcriptional regulator
HUW51_RS24430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family