locus-tag	class	description
HRR28_RS00015	COG3437	response regulator, receiver
HRR28_RS00040	COG1053	succinate dehydrogenase
HRR28_RS00040	COG3976	FMN-binding domain protein
HRR28_RS00040	COG0431	NADPH-dependent FMN reductase
HRR28_RS00045	COG0745	RESPONSE REGULATOR receiver
HRR28_RS00050	COG2205	protein histidine kinase activity
HRR28_RS00055	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS00060	COG0243	molybdopterin cofactor binding
HRR28_RS00115	COG3976	FMN-binding domain protein
HRR28_RS00115	COG1053	succinate dehydrogenase
HRR28_RS00150	COG0765	amino acid transport
HRR28_RS00155	COG4598	ABC transporter
HRR28_RS00170	COG1842	Phage shock protein A
HRR28_RS00235	COG5002	protein histidine kinase activity
HRR28_RS00240	COG0745	RESPONSE REGULATOR receiver
HRR28_RS00245	COG1283	sodium-dependent phosphate transmembrane transporter activity
HRR28_RS00250	COG3976	FMN-binding domain protein
HRR28_RS00250	COG1053	succinate dehydrogenase
HRR28_RS00250	COG0431	NADPH-dependent FMN reductase
HRR28_RS00255	COG2197	response regulator
HRR28_RS00270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HRR28_RS00275	COG0581	inorganic phosphate transmembrane transporter activity
HRR28_RS00280	COG0573	inorganic phosphate transmembrane transporter activity
HRR28_RS00305	COG1131	(ABC) transporter
HRR28_RS00315	COG1328	CTP reductase activity
HRR28_RS00325	COG1122	ATPase activity
HRR28_RS00345	COG1511	domain protein
HRR28_RS00365	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HRR28_RS00375	COG0436	Aminotransferase
HRR28_RS00400	COG1979	alcohol dehydrogenase
HRR28_RS00420	COG1045	serine acetyltransferase
HRR28_RS00425	COG2814	Major facilitator Superfamily
HRR28_RS00430	COG1253	flavin adenine dinucleotide binding
HRR28_RS00435	COG2197	response regulator
HRR28_RS00460	COG1122	ATPase activity
HRR28_RS00465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRR28_RS00540	COG2801	Transposase and inactivated derivatives
HRR28_RS00590	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HRR28_RS00595	COG0187	DNA topoisomerase II activity
HRR28_RS00600	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HRR28_RS00615	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRR28_RS00620	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HRR28_RS00625	COG0594	ribonuclease P activity
HRR28_RS00635	COG0706	membrane insertase activity
HRR28_RS00640	COG1847	R3H domain protein
HRR28_RS00645	COG0357	Ribosomal RNA small subunit methyltransferase G
HRR28_RS00650	COG1192	Involved in chromosome partitioning
HRR28_RS00680	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HRR28_RS00685	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRR28_RS00695	COG1199	ATP-dependent helicase activity
HRR28_RS00695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRR28_RS00725	COG0629	single-stranded DNA binding
HRR28_RS00730	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HRR28_RS00735	COG0359	binds to the 23S rRNA
HRR28_RS00740	COG0305	Participates in initiation and elongation during chromosome replication
HRR28_RS00750	COG4717	serine-type aminopeptidase activity
HRR28_RS00760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HRR28_RS00795	COG0622	Phosphoesterase
HRR28_RS00800	COG3706	GGDEF domain
HRR28_RS00810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HRR28_RS00815	COG0531	amino acid
HRR28_RS00840	COG1396	sequence-specific DNA binding
HRR28_RS00845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRR28_RS00855	COG0778	Nitroreductase
HRR28_RS00870	COG1192	Involved in chromosome partitioning
HRR28_RS00875	COG1475	DNA binding
HRR28_RS00895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRR28_RS00910	COG0270	DNA (cytosine-5-)-methyltransferase activity
HRR28_RS00985	COG4166	transmembrane transport
HRR28_RS01015	COG3328	transposase activity
HRR28_RS01035	COG3433	isochorismatase activity
HRR28_RS01035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HRR28_RS01035	COG2226	methyltransferase
HRR28_RS01040	COG2226	methyltransferase
HRR28_RS01040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HRR28_RS01040	COG3433	isochorismatase activity
HRR28_RS01045	COG1021	2,3-dihydroxybenzoate-AMP ligase
HRR28_RS01060	COG1132	(ABC) transporter
HRR28_RS01070	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HRR28_RS01080	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HRR28_RS01090	COG3328	transposase activity
HRR28_RS01100	COG2337	Toxic component of a toxin-antitoxin (TA) module
HRR28_RS01140	COG1475	DNA binding
HRR28_RS01155	COG1484	DNA-dependent DNA replication
HRR28_RS01160	COG4584	PFAM Integrase catalytic
HRR28_RS01175	COG3328	transposase activity
HRR28_RS01205	COG1053	succinate dehydrogenase
HRR28_RS01225	COG5002	protein histidine kinase activity
HRR28_RS01255	COG1129	ABC transporter
HRR28_RS01270	COG1132	(ABC) transporter
HRR28_RS01290	COG1012	belongs to the aldehyde dehydrogenase family
HRR28_RS01310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRR28_RS01330	COG0864	Transcriptional regulator
HRR28_RS01360	COG0443	Heat shock 70 kDa protein
HRR28_RS01365	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRR28_RS01370	COG0484	heat shock protein binding
HRR28_RS01375	COG0789	Transcriptional regulator
HRR28_RS01380	COG0542	response to heat
HRR28_RS01390	COG3976	FMN-binding domain protein
HRR28_RS01390	COG0431	NADPH-dependent FMN reductase
HRR28_RS01390	COG1053	succinate dehydrogenase
HRR28_RS01400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRR28_RS01405	COG3279	Response regulator of the LytR AlgR family
HRR28_RS01410	COG0166	Belongs to the GPI family
HRR28_RS01415	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HRR28_RS01420	COG0298	carbon dioxide binding
HRR28_RS01430	COG2827	Endonuclease containing a URI domain
HRR28_RS01500	COG1610	YqeY-like protein
HRR28_RS01505	COG0577	efflux transmembrane transporter activity
HRR28_RS01510	COG1136	(ABC) transporter
HRR28_RS01515	COG2205	protein histidine kinase activity
HRR28_RS01540	COG3428	Bacterial PH domain
HRR28_RS01545	COG4535	Mg2 and Co2 transporter CorC
HRR28_RS01555	COG0569	domain protein
HRR28_RS01575	COG1115	amino acid carrier protein
HRR28_RS01580	COG1763	Mo-molybdopterin cofactor biosynthetic process
HRR28_RS01595	COG0765	amino acid transport
HRR28_RS01605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRR28_RS01610	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HRR28_RS01620	COG3655	Transcriptional regulator
HRR28_RS01670	COG0528	UMP kinase activity
HRR28_RS01675	COG0233	cytoplasmic translational termination
HRR28_RS01685	COG4589	Belongs to the CDS family
HRR28_RS01690	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HRR28_RS01700	COG0750	zinc metalloprotease
HRR28_RS01705	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HRR28_RS01710	COG0442	prolyl-tRNA aminoacylation
HRR28_RS01725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRR28_RS01735	COG3620	sequence-specific DNA binding
HRR28_RS01765	COG0644	oxidoreductase
HRR28_RS01770	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HRR28_RS01775	COG2814	Major facilitator Superfamily
HRR28_RS01780	COG0318	PFAM AMP-dependent synthetase and ligase
HRR28_RS01835	COG3328	transposase activity
HRR28_RS01840	COG2197	response regulator
HRR28_RS01865	COG0542	response to heat
HRR28_RS01895	COG0745	RESPONSE REGULATOR receiver
HRR28_RS01900	COG2205	protein histidine kinase activity
HRR28_RS01900	COG2198	Histidine kinase
HRR28_RS01900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRR28_RS01900	COG0784	Response regulator, receiver
HRR28_RS01905	COG0243	molybdopterin cofactor binding
HRR28_RS01910	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS01920	COG1136	(ABC) transporter
HRR28_RS01975	COG5012	cobalamin binding
HRR28_RS01995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRR28_RS02000	COG0402	S-adenosylhomocysteine deaminase activity
HRR28_RS02010	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRR28_RS02015	COG0085	RNA polymerase activity
HRR28_RS02020	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HRR28_RS02025	COG0583	DNA-binding transcription factor activity
HRR28_RS02085	COG0140	phosphoribosyl-ATP diphosphatase activity
HRR28_RS02090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRR28_RS02100	COG0733	neurotransmitter:sodium symporter activity
HRR28_RS02115	COG2076	Multidrug Resistance protein
HRR28_RS02135	COG2326	polyphosphate kinase activity
HRR28_RS02140	COG4509	Sortase family
HRR28_RS02145	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HRR28_RS02155	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HRR28_RS02170	COG0138	bifunctional purine biosynthesis protein purh
HRR28_RS02200	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HRR28_RS02210	COG1979	alcohol dehydrogenase
HRR28_RS02225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRR28_RS02230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRR28_RS02235	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HRR28_RS02250	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HRR28_RS02285	COG2357	RelA SpoT domain protein
HRR28_RS02300	COG0215	cysteine-tRNA ligase activity
HRR28_RS02320	COG0545	Peptidyl-prolyl cis-trans isomerase
HRR28_RS02325	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HRR28_RS02330	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HRR28_RS02335	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRR28_RS02340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRR28_RS02345	COG0137	argininosuccinate synthase activity
HRR28_RS02355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRR28_RS02365	COG0826	peptidase U32
HRR28_RS02385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HRR28_RS02440	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HRR28_RS02445	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HRR28_RS02470	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HRR28_RS02475	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HRR28_RS02480	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HRR28_RS02495	COG1288	antiporter activity
HRR28_RS02505	COG0024	Methionine aminopeptidase
HRR28_RS02525	COG0477	Major facilitator Superfamily
HRR28_RS02540	COG0484	heat shock protein binding
HRR28_RS02570	COG1924	4 iron, 4 sulfur cluster binding
HRR28_RS02575	COG3381	protein complex oligomerization
HRR28_RS02585	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS02590	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS02595	COG0243	molybdopterin cofactor binding
HRR28_RS02605	COG2814	Major facilitator Superfamily
HRR28_RS02620	COG0326	Molecular chaperone. Has ATPase activity
HRR28_RS02640	COG3956	TIGRFAM MazG family protein
HRR28_RS02650	COG3976	FMN-binding domain protein
HRR28_RS02650	COG1053	succinate dehydrogenase
HRR28_RS02655	COG3328	transposase activity
HRR28_RS02665	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HRR28_RS02675	COG0792	nuclease activity
HRR28_RS02685	COG1192	Involved in chromosome partitioning
HRR28_RS02755	COG1910	domain protein
HRR28_RS02800	COG0791	NLP P60 protein
HRR28_RS02835	COG1484	DNA-dependent DNA replication
HRR28_RS02860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRR28_RS02905	COG0640	Transcriptional regulator
HRR28_RS02950	COG1373	ATPase (AAA superfamily
HRR28_RS02955	COG1397	ADP-ribosylglycohydrolase
HRR28_RS02960	COG3177	Filamentation induced by cAMP protein fic
HRR28_RS03020	COG3328	transposase activity
HRR28_RS03085	COG1028	Short-chain dehydrogenase reductase Sdr
HRR28_RS03090	COG0659	secondary active sulfate transmembrane transporter activity
HRR28_RS03095	COG0363	glucosamine-6-phosphate deaminase activity
HRR28_RS03120	COG2832	Protein of unknown function (DUF454)
HRR28_RS03135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRR28_RS03140	COG0569	domain protein
HRR28_RS03155	COG0659	secondary active sulfate transmembrane transporter activity
HRR28_RS03165	COG1053	succinate dehydrogenase
HRR28_RS03165	COG0431	NADPH-dependent FMN reductase
HRR28_RS03165	COG3976	FMN-binding domain protein
HRR28_RS03180	COG2153	protein acetylation
HRR28_RS03190	COG0549	Belongs to the carbamate kinase family
HRR28_RS03210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HRR28_RS03220	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HRR28_RS03230	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HRR28_RS03245	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRR28_RS03265	COG1028	Short-chain dehydrogenase reductase Sdr
HRR28_RS03275	COG1053	succinate dehydrogenase
HRR28_RS03305	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HRR28_RS03325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HRR28_RS03325	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HRR28_RS03360	COG2205	protein histidine kinase activity
HRR28_RS03360	COG3850	Histidine kinase
HRR28_RS03360	COG4999	Histidine kinase
HRR28_RS03360	COG3437	response regulator, receiver
HRR28_RS03365	COG2205	protein histidine kinase activity
HRR28_RS03365	COG0784	Response regulator, receiver
HRR28_RS03370	COG0251	oxidation-reduction process
HRR28_RS03375	COG1234	tRNA 3'-trailer cleavage
HRR28_RS03390	COG3973	AAA domain
HRR28_RS03395	COG1132	(ABC) transporter
HRR28_RS03405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRR28_RS03410	COG3976	FMN-binding domain protein
HRR28_RS03410	COG1053	succinate dehydrogenase
HRR28_RS03410	COG0431	NADPH-dependent FMN reductase
HRR28_RS03420	COG1115	amino acid carrier protein
HRR28_RS03430	COG1053	succinate dehydrogenase
HRR28_RS03440	COG2949	membrane
HRR28_RS03455	COG1053	succinate dehydrogenase
HRR28_RS03465	COG1053	succinate dehydrogenase
HRR28_RS03480	COG1489	DNA binding
HRR28_RS03485	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HRR28_RS03490	COG1490	D-aminoacyl-tRNA deacylase activity
HRR28_RS03510	COG0243	molybdopterin cofactor binding
HRR28_RS03515	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS03540	COG1053	succinate dehydrogenase
HRR28_RS03560	COG3250	beta-galactosidase activity
HRR28_RS03570	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HRR28_RS03575	COG3885	ferrous iron binding
HRR28_RS03575	COG2078	PFAM AMMECR1 domain protein
HRR28_RS03580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRR28_RS03595	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HRR28_RS03600	COG1272	protein, Hemolysin III
HRR28_RS03605	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HRR28_RS03610	COG1528	Iron-storage protein
HRR28_RS03615	COG0577	efflux transmembrane transporter activity
HRR28_RS03615	COG1136	(ABC) transporter
HRR28_RS03620	COG1950	PFAM Membrane protein of
HRR28_RS03625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRR28_RS03630	COG0037	tRNA processing
HRR28_RS03645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRR28_RS03650	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HRR28_RS03665	COG1268	BioY protein
HRR28_RS03670	COG0745	RESPONSE REGULATOR receiver
HRR28_RS03675	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HRR28_RS03680	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HRR28_RS03685	COG3404	Formiminotransferase-cyclodeaminase
HRR28_RS03690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRR28_RS03695	COG2909	trisaccharide binding
HRR28_RS03700	COG3976	FMN-binding domain protein
HRR28_RS03700	COG1053	succinate dehydrogenase
HRR28_RS03705	COG2116	formate transmembrane transporter activity
HRR28_RS03710	COG0802	atpase or kinase
HRR28_RS03725	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HRR28_RS03740	COG2205	protein histidine kinase activity
HRR28_RS03745	COG0745	RESPONSE REGULATOR receiver
HRR28_RS03765	COG0243	molybdopterin cofactor binding
HRR28_RS03770	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS03790	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
HRR28_RS03810	COG0402	S-adenosylhomocysteine deaminase activity
HRR28_RS03820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRR28_RS03825	COG0805	protein transport
HRR28_RS03830	COG0375	protein maturation
HRR28_RS03835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRR28_RS03835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HRR28_RS03840	COG4585	Histidine kinase
HRR28_RS03845	COG2197	response regulator
HRR28_RS03850	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRR28_RS03855	COG0459	protein refolding
HRR28_RS03880	COG1966	Carbon starvation protein
HRR28_RS03895	COG2814	Major facilitator Superfamily
HRR28_RS03910	COG2918	glutathione biosynthetic process
HRR28_RS03910	COG0189	ligase activity
HRR28_RS03920	COG2957	Belongs to the agmatine deiminase family
HRR28_RS03925	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRR28_RS03945	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HRR28_RS03960	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HRR28_RS03965	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HRR28_RS03970	COG0202	RNA polymerase activity
HRR28_RS03975	COG0203	ribosomal protein L17
HRR28_RS03985	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HRR28_RS03995	COG4716	Myosin-crossreactive antigen
HRR28_RS04015	COG1053	succinate dehydrogenase
HRR28_RS04015	COG3976	FMN-binding domain protein
HRR28_RS04025	COG1132	(ABC) transporter
HRR28_RS04030	COG0303	'Molybdopterin
HRR28_RS04035	COG0521	Mo-molybdopterin cofactor biosynthetic process
HRR28_RS04040	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HRR28_RS04045	COG1573	uracil-dna glycosylase
HRR28_RS04050	COG0598	Magnesium transport protein CorA
HRR28_RS04060	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HRR28_RS04075	COG1937	Protein conserved in bacteria
HRR28_RS04080	COG2217	Heavy metal translocating P-type atpase
HRR28_RS04090	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HRR28_RS04095	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HRR28_RS04100	COG0193	aminoacyl-tRNA hydrolase activity
HRR28_RS04105	COG2814	Major facilitator Superfamily
HRR28_RS04110	COG0488	(ABC) transporter
HRR28_RS04115	COG1739	Uncharacterized protein family UPF0029
HRR28_RS04120	COG0720	synthase
HRR28_RS04125	COG0602	queuosine metabolic process
HRR28_RS04130	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HRR28_RS04135	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HRR28_RS04140	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HRR28_RS04140	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HRR28_RS04145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRR28_RS04150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRR28_RS04155	COG0306	phosphate transporter
HRR28_RS04165	COG2860	membrane
HRR28_RS04180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HRR28_RS04225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRR28_RS04235	COG1760	l-serine dehydratase
HRR28_RS04240	COG1227	inorganic diphosphatase activity
HRR28_RS04245	COG2195	Cleaves the N-terminal amino acid of tripeptides
HRR28_RS04260	COG1053	succinate dehydrogenase
HRR28_RS04260	COG3976	FMN-binding domain protein
HRR28_RS04275	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HRR28_RS04280	COG0049	tRNA binding
HRR28_RS04285	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRR28_RS04290	COG0051	transcription antitermination factor activity, RNA binding
HRR28_RS04295	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HRR28_RS04300	COG0088	Forms part of the polypeptide exit tunnel
HRR28_RS04305	COG0089	rRNA binding
HRR28_RS04320	COG2197	response regulator
HRR28_RS04345	COG1136	(ABC) transporter
HRR28_RS04365	COG0544	peptidyl-prolyl cis-trans isomerase activity
HRR28_RS04380	COG1053	succinate dehydrogenase
HRR28_RS04385	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HRR28_RS04400	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HRR28_RS04425	COG1053	succinate dehydrogenase
HRR28_RS04425	COG3976	FMN-binding domain protein
HRR28_RS04430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HRR28_RS04435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HRR28_RS04445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HRR28_RS04450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HRR28_RS04460	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HRR28_RS04465	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HRR28_RS04470	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HRR28_RS04475	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HRR28_RS04480	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HRR28_RS04485	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HRR28_RS04490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HRR28_RS04495	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HRR28_RS04500	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HRR28_RS04505	COG1841	ribosomal large subunit assembly
HRR28_RS04510	COG0200	Binds to the 23S rRNA
HRR28_RS04520	COG0563	adenylate kinase activity
HRR28_RS04530	COG0747	negative chemotaxis
HRR28_RS04535	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRR28_RS04535	COG0674	pyruvate-flavodoxin oxidoreductase activity
HRR28_RS04535	COG1013	pyruvate-flavodoxin oxidoreductase activity
HRR28_RS04535	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HRR28_RS04540	COG0243	molybdopterin cofactor binding
HRR28_RS04550	COG2205	protein histidine kinase activity
HRR28_RS04555	COG0745	RESPONSE REGULATOR receiver
HRR28_RS04565	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HRR28_RS04565	COG3976	FMN-binding domain protein
HRR28_RS04570	COG0243	molybdopterin cofactor binding
HRR28_RS04575	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS04590	COG1725	Transcriptional regulator
HRR28_RS04615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRR28_RS04620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRR28_RS04625	COG0426	domain, Protein
HRR28_RS04650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRR28_RS04655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HRR28_RS04665	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HRR28_RS04670	COG0250	Participates in transcription elongation, termination and antitermination
HRR28_RS04675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HRR28_RS04680	COG0081	regulation of translation
HRR28_RS04685	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HRR28_RS04695	COG0024	Methionine aminopeptidase
HRR28_RS04700	COG0504	CTP synthase activity
HRR28_RS04735	COG2860	membrane
HRR28_RS04740	COG0252	asparaginase activity
HRR28_RS04745	COG4974	Belongs to the 'phage' integrase family
HRR28_RS04750	COG2001	Belongs to the MraZ family
HRR28_RS04755	COG0275	rRNA processing
HRR28_RS04765	COG0768	penicillin binding
HRR28_RS04770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HRR28_RS04785	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HRR28_RS04790	COG0772	Belongs to the SEDS family
HRR28_RS04795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRR28_RS04800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRR28_RS04805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HRR28_RS04810	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HRR28_RS04815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HRR28_RS04830	COG1799	cell septum assembly
HRR28_RS04835	COG0762	integral membrane protein
HRR28_RS04850	COG1053	succinate dehydrogenase
HRR28_RS04875	COG1564	THIamine pyrophosphokinase
HRR28_RS04880	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HRR28_RS04885	COG0352	thiamine-phosphate diphosphorylase activity
HRR28_RS04890	COG1335	isochorismatase
HRR28_RS04895	COG0351	phosphomethylpyrimidine kinase
HRR28_RS04920	COG0617	tRNA 3'-terminal CCA addition
HRR28_RS04955	COG4149	molybdate abc transporter
HRR28_RS04970	COG0243	molybdopterin cofactor binding
HRR28_RS04975	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS04985	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HRR28_RS04985	COG3976	FMN-binding domain protein
HRR28_RS04995	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HRR28_RS05005	COG3976	FMN-binding domain protein
HRR28_RS05005	COG0431	NADPH-dependent FMN reductase
HRR28_RS05005	COG1053	succinate dehydrogenase
HRR28_RS05010	COG2909	trisaccharide binding
HRR28_RS05025	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRR28_RS05025	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRR28_RS05040	COG0217	transcriptional regulatory protein
HRR28_RS05045	COG1028	Short-chain dehydrogenase reductase Sdr
HRR28_RS05055	COG0632	four-way junction helicase activity
HRR28_RS05060	COG2255	four-way junction helicase activity
HRR28_RS05070	COG1278	Cold shock
HRR28_RS05075	COG2226	methyltransferase
HRR28_RS05080	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HRR28_RS05085	COG3872	metal-dependent enzyme
HRR28_RS05090	COG1126	abc transporter atp-binding protein
HRR28_RS05095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRR28_RS05100	COG0765	amino acid transport
HRR28_RS05105	COG0765	amino acid transport
HRR28_RS05145	COG0551	DNA topoisomerase type I activity
HRR28_RS05145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRR28_RS05150	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HRR28_RS05150	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HRR28_RS05160	COG0281	malic enzyme
HRR28_RS05165	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HRR28_RS05175	COG1774	PSP1 C-terminal conserved region
HRR28_RS05180	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HRR28_RS05185	COG1307	EDD domain protein, DegV family
HRR28_RS05200	COG1307	EDD domain protein, DegV family
HRR28_RS05235	COG1363	Peptidase, m42
HRR28_RS05240	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HRR28_RS05265	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HRR28_RS05275	COG0789	Transcriptional regulator
HRR28_RS05280	COG1691	(AIR) carboxylase
HRR28_RS05285	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HRR28_RS05290	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HRR28_RS05295	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HRR28_RS05300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRR28_RS05305	COG0131	Imidazoleglycerol-phosphate dehydratase
HRR28_RS05310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HRR28_RS05315	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HRR28_RS05320	COG0107	imidazoleglycerol-phosphate synthase activity
HRR28_RS05345	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HRR28_RS05360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HRR28_RS05375	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRR28_RS05375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRR28_RS05380	COG0052	Belongs to the universal ribosomal protein uS2 family
HRR28_RS05385	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HRR28_RS05390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HRR28_RS05400	COG0316	Belongs to the HesB IscA family
HRR28_RS05400	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HRR28_RS05415	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HRR28_RS05420	COG2033	superoxide reductase activity
HRR28_RS05430	COG0174	glutamine synthetase
HRR28_RS05435	COG0745	RESPONSE REGULATOR receiver
HRR28_RS05440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRR28_RS05440	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRR28_RS05445	COG2197	response regulator
HRR28_RS05450	COG2235	arginine
HRR28_RS05455	COG1288	antiporter activity
HRR28_RS05480	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HRR28_RS05485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HRR28_RS05490	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HRR28_RS05495	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HRR28_RS05500	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HRR28_RS05505	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HRR28_RS05510	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HRR28_RS05510	COG1713	HD superfamily hydrolase involved in NAD metabolism
HRR28_RS05515	COG0799	negative regulation of ribosome biogenesis
HRR28_RS05525	COG1271	oxidase subunit
HRR28_RS05530	COG1294	oxidase, subunit
HRR28_RS05540	COG0653	protein targeting
HRR28_RS05545	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HRR28_RS05555	COG3958	Transketolase
HRR28_RS05560	COG2884	Cell division ATP-binding protein ftsE
HRR28_RS05565	COG2177	Part of the ABC transporter FtsEX involved in
HRR28_RS05575	COG0557	exoribonuclease II activity
HRR28_RS05600	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS05610	COG0733	neurotransmitter:sodium symporter activity
HRR28_RS05625	COG0747	negative chemotaxis
HRR28_RS05630	COG0601	transmembrane transport
HRR28_RS05635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRR28_RS05640	COG1136	(ABC) transporter
HRR28_RS05655	COG1837	Belongs to the UPF0109 family
HRR28_RS05665	COG0336	Belongs to the RNA methyltransferase TrmD family
HRR28_RS05670	COG0681	Belongs to the peptidase S26 family
HRR28_RS05680	COG0751	glycine-tRNA ligase activity
HRR28_RS05685	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HRR28_RS05695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRR28_RS05695	COG0574	Belongs to the PEP-utilizing enzyme family
HRR28_RS05700	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HRR28_RS05705	COG1192	Involved in chromosome partitioning
HRR28_RS05720	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HRR28_RS05735	COG1132	(ABC) transporter
HRR28_RS05750	COG1194	a g-specific adenine glycosylase
HRR28_RS05765	COG0077	Prephenate dehydratase
HRR28_RS05770	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HRR28_RS05815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HRR28_RS05845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRR28_RS05860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HRR28_RS05880	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HRR28_RS05885	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HRR28_RS05895	COG0515	serine threonine protein kinase
HRR28_RS05940	COG0243	molybdopterin cofactor binding
HRR28_RS05945	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS05960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRR28_RS05965	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HRR28_RS05965	COG0116	Belongs to the methyltransferase superfamily
HRR28_RS05980	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HRR28_RS06015	COG0544	peptidyl-prolyl cis-trans isomerase activity
HRR28_RS06020	COG0740	serine-type endopeptidase activity
HRR28_RS06025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HRR28_RS06030	COG0525	valine-tRNA ligase activity
HRR28_RS06040	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HRR28_RS06050	COG4145	pantothenate transmembrane transporter activity
HRR28_RS06055	COG0492	ferredoxin-NADP+ reductase activity
HRR28_RS06065	COG0475	glutathione-regulated potassium exporter activity
HRR28_RS06065	COG0569	domain protein
HRR28_RS06070	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HRR28_RS06075	COG2890	protein-(glutamine-N5) methyltransferase activity
HRR28_RS06095	COG0129	dihydroxy-acid dehydratase activity
HRR28_RS06100	COG0028	Belongs to the TPP enzyme family
HRR28_RS06105	COG0440	acetolactate synthase activity
HRR28_RS06110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HRR28_RS06115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRR28_RS06125	COG0328	RNA-DNA hybrid ribonuclease activity
HRR28_RS06140	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HRR28_RS06145	COG0358	DNA primase activity
HRR28_RS06150	COG0242	peptide deformylase activity
HRR28_RS06155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HRR28_RS06160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HRR28_RS06160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRR28_RS06170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRR28_RS06180	COG1144	Oxidoreductase
HRR28_RS06185	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HRR28_RS06185	COG0674	pyruvate-flavodoxin oxidoreductase activity
HRR28_RS06205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRR28_RS06215	COG1592	Rubrerythrin
HRR28_RS06220	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HRR28_RS06225	COG0540	Belongs to the ATCase OTCase family
HRR28_RS06230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HRR28_RS06235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRR28_RS06240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRR28_RS06245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRR28_RS06250	COG1120	ATPase activity
HRR28_RS06285	COG0505	Belongs to the CarA family
HRR28_RS06290	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HRR28_RS06295	COG0543	2 iron, 2 sulfur cluster binding
HRR28_RS06300	COG0167	dihydroorotate dehydrogenase activity
HRR28_RS06305	COG0284	orotidine-5'-phosphate decarboxylase activity
HRR28_RS06315	COG0194	GDP metabolic process
HRR28_RS06325	COG0301	tRNA thio-modification
HRR28_RS06330	COG1555	photosystem II stabilization
HRR28_RS06330	COG1596	polysaccharide export
HRR28_RS06335	COG0658	competence protein
HRR28_RS06335	COG2333	competence protein COMEC
HRR28_RS06345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRR28_RS06350	COG0268	Binds directly to 16S ribosomal RNA
HRR28_RS06355	COG0481	GTPase activity
HRR28_RS06370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRR28_RS06375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRR28_RS06380	COG1420	regulation of RNA biosynthetic process
HRR28_RS06385	COG0484	heat shock protein binding
HRR28_RS06390	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HRR28_RS06395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRR28_RS06410	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HRR28_RS06430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HRR28_RS06435	COG1185	polyribonucleotide nucleotidyltransferase activity
HRR28_RS06440	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HRR28_RS06445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRR28_RS06450	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HRR28_RS06465	COG1666	GTP binding
HRR28_RS06470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRR28_RS06475	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HRR28_RS06490	COG1418	mRNA catabolic process
HRR28_RS06500	COG2359	stage V sporulation protein S
HRR28_RS06505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRR28_RS06510	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HRR28_RS06520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HRR28_RS06525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRR28_RS06530	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HRR28_RS06535	COG0756	dUTP diphosphatase activity
HRR28_RS06630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRR28_RS06635	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HRR28_RS06660	COG1686	Belongs to the peptidase S11 family
HRR28_RS06675	COG2720	vancomycin resistance protein
HRR28_RS06685	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRR28_RS06700	COG3260	NADH ubiquinone oxidoreductase 20
HRR28_RS06725	COG1053	succinate dehydrogenase
HRR28_RS06725	COG3976	FMN-binding domain protein
HRR28_RS06725	COG0431	NADPH-dependent FMN reductase
HRR28_RS06730	COG4566	intracellular signal transduction
HRR28_RS06735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRR28_RS06750	COG1053	succinate dehydrogenase
HRR28_RS06755	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRR28_RS06760	COG0564	pseudouridine synthase activity
HRR28_RS06765	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HRR28_RS06770	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HRR28_RS06780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRR28_RS06785	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HRR28_RS06790	COG1215	transferase activity, transferring glycosyl groups
HRR28_RS06800	COG0280	phosphate acetyltransferase
HRR28_RS06815	COG1053	succinate dehydrogenase
HRR28_RS06815	COG3976	FMN-binding domain protein
HRR28_RS06820	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HRR28_RS06825	COG1722	exodeoxyribonuclease VII activity
HRR28_RS06830	COG1570	exodeoxyribonuclease VII activity
HRR28_RS06835	COG2738	Putative neutral zinc metallopeptidase
HRR28_RS06840	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HRR28_RS06845	COG1597	lipid kinase activity
HRR28_RS06915	COG0861	Integral membrane protein TerC family
HRR28_RS06935	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HRR28_RS06940	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HRR28_RS06960	COG1481	regulation of sporulation
HRR28_RS06965	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HRR28_RS06970	COG1660	Displays ATPase and GTPase activities
HRR28_RS06975	COG0322	excinuclease ABC activity
HRR28_RS06985	COG0196	riboflavin kinase activity
HRR28_RS06990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HRR28_RS06995	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HRR28_RS07000	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HRR28_RS07005	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HRR28_RS07005	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HRR28_RS07015	COG0195	Participates in both transcription termination and antitermination
HRR28_RS07020	COG0779	Required for maturation of 30S ribosomal subunits
HRR28_RS07025	COG0583	DNA-binding transcription factor activity
HRR28_RS07040	COG1960	acyl-CoA dehydrogenase activity
HRR28_RS07050	COG1053	succinate dehydrogenase
HRR28_RS07050	COG3976	FMN-binding domain protein
HRR28_RS07060	COG0318	PFAM AMP-dependent synthetase and ligase
HRR28_RS07065	COG0318	PFAM AMP-dependent synthetase and ligase
HRR28_RS07085	COG0247	lactate metabolic process
HRR28_RS07085	COG2181	nitrate reductase activity
HRR28_RS07090	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HRR28_RS07095	COG2086	electron transfer activity
HRR28_RS07100	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HRR28_RS07115	COG1960	acyl-CoA dehydrogenase activity
HRR28_RS07135	COG0318	PFAM AMP-dependent synthetase and ligase
HRR28_RS07145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRR28_RS07150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRR28_RS07155	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HRR28_RS07175	COG1074	ATP-dependent DNA helicase activity
HRR28_RS07215	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRR28_RS07225	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HRR28_RS07235	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HRR28_RS07250	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HRR28_RS07255	COG0758	DNA mediated transformation
HRR28_RS07260	COG0606	chelatase, subunit chli
HRR28_RS07265	COG0792	nuclease activity
HRR28_RS07275	COG0335	large ribosomal subunit rRNA binding
HRR28_RS07295	COG1151	hydroxylamine reductase activity
HRR28_RS07305	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HRR28_RS07320	COG0537	adenosine 5'-monophosphoramidase activity
HRR28_RS07340	COG0772	Belongs to the SEDS family
HRR28_RS07355	COG1792	Involved in formation and maintenance of cell shape
HRR28_RS07360	COG1077	Cell shape determining protein MreB Mrl
HRR28_RS07365	COG3976	FMN-binding domain protein
HRR28_RS07365	COG0431	NADPH-dependent FMN reductase
HRR28_RS07365	COG1053	succinate dehydrogenase
HRR28_RS07400	COG0105	UTP biosynthetic process
HRR28_RS07410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRR28_RS07415	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRR28_RS07425	COG1597	lipid kinase activity
HRR28_RS07445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRR28_RS07450	COG0513	Belongs to the DEAD box helicase family
HRR28_RS07460	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HRR28_RS07470	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HRR28_RS07490	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HRR28_RS07510	COG1215	transferase activity, transferring glycosyl groups
HRR28_RS07515	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HRR28_RS07525	COG2226	methyltransferase
HRR28_RS07565	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS07570	COG0243	molybdopterin cofactor binding
HRR28_RS07595	COG1196	nuclear chromosome segregation
HRR28_RS07600	COG0571	ribonuclease III activity
HRR28_RS07605	COG0416	fatty acid biosynthetic process
HRR28_RS07610	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HRR28_RS07615	COG0038	chloride channel
HRR28_RS07630	COG0742	ribosomal rna small subunit methyltransferase
HRR28_RS07635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HRR28_RS07640	COG1461	Dihydroxyacetone kinase
HRR28_RS07645	COG1302	Protein conserved in bacteria
HRR28_RS07650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HRR28_RS07670	COG1104	cysteine desulfurase activity
HRR28_RS07675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HRR28_RS07680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HRR28_RS07695	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HRR28_RS07700	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HRR28_RS07705	COG1160	GTP binding
HRR28_RS07715	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HRR28_RS07720	COG0204	Acyl-transferase
HRR28_RS07725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HRR28_RS07820	COG2205	protein histidine kinase activity
HRR28_RS07820	COG0784	Response regulator, receiver
HRR28_RS07835	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HRR28_RS07840	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HRR28_RS07845	COG1187	pseudouridine synthase activity
HRR28_RS07860	COG1994	Peptidase M50
HRR28_RS07865	COG0025	NhaP-type Na H and K H
HRR28_RS07875	COG0488	(ABC) transporter
HRR28_RS07880	COG0494	nUDIX hydrolase
HRR28_RS07895	COG0180	Tryptophanyl-tRNA synthetase
HRR28_RS07900	COG0025	NhaP-type Na H and K H
HRR28_RS07920	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HRR28_RS07935	COG0018	arginyl-trna synthetase
HRR28_RS07940	COG1288	antiporter activity
HRR28_RS07945	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRR28_RS07950	COG2235	arginine
HRR28_RS07980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRR28_RS08005	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HRR28_RS08010	COG2202	Pas domain
HRR28_RS08010	COG2205	protein histidine kinase activity
HRR28_RS08015	COG0745	RESPONSE REGULATOR receiver
HRR28_RS08020	COG1013	pyruvate-flavodoxin oxidoreductase activity
HRR28_RS08025	COG0674	pyruvate-flavodoxin oxidoreductase activity
HRR28_RS08035	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HRR28_RS08045	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HRR28_RS08055	COG0549	Belongs to the carbamate kinase family
HRR28_RS08070	COG2957	Belongs to the agmatine deiminase family
HRR28_RS08075	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRR28_RS08085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRR28_RS08090	COG0154	amidase activity
HRR28_RS08095	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRR28_RS08115	COG0012	GTP binding
HRR28_RS08120	COG0733	neurotransmitter:sodium symporter activity
HRR28_RS08125	COG4656	Part of a membrane complex involved in electron transport
HRR28_RS08130	COG0101	tRNA pseudouridine synthase activity
HRR28_RS08160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HRR28_RS08165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HRR28_RS08170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HRR28_RS08175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRR28_RS08180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRR28_RS08190	COG0356	it plays a direct role in the translocation of protons across the membrane
HRR28_RS08200	COG2131	deaminase
HRR28_RS08215	COG0698	ribose 5-phosphate isomerase
HRR28_RS08220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRR28_RS08225	COG1401	restriction endodeoxyribonuclease activity
HRR28_RS08240	COG2267	carboxylic ester hydrolase activity
HRR28_RS08250	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HRR28_RS08255	COG2081	HI0933 family
HRR28_RS08260	COG1115	amino acid carrier protein
HRR28_RS08265	COG1115	amino acid carrier protein
HRR28_RS08275	COG4566	intracellular signal transduction
HRR28_RS08290	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HRR28_RS08295	COG0644	oxidoreductase
HRR28_RS08305	COG2086	electron transfer activity
HRR28_RS08325	COG1024	Enoyl-CoA hydratase
HRR28_RS08330	COG1960	acyl-CoA dehydrogenase activity
HRR28_RS08340	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HRR28_RS08345	COG1122	ATPase activity
HRR28_RS08350	COG1122	ATPase activity
HRR28_RS08360	COG1120	ATPase activity
HRR28_RS08365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRR28_RS08375	COG0535	radical SAM domain protein
HRR28_RS08390	COG2197	response regulator
HRR28_RS08400	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRR28_RS08400	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRR28_RS08410	COG2197	response regulator
HRR28_RS08425	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HRR28_RS08430	COG0343	queuine tRNA-ribosyltransferase activity
HRR28_RS08440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRR28_RS08440	COG1773	rubredoxin
HRR28_RS08460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRR28_RS08470	COG1376	ErfK ybiS ycfS ynhG family protein
HRR28_RS08475	COG4193	domain, Protein
HRR28_RS08480	COG1088	dTDP-glucose 4,6-dehydratase activity
HRR28_RS08485	COG0151	Belongs to the GarS family
HRR28_RS08500	COG0463	Glycosyl transferase, family 2
HRR28_RS08505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRR28_RS08520	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HRR28_RS08550	COG1696	Membrane protein involved in D-alanine export
HRR28_RS08555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HRR28_RS08570	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HRR28_RS08570	COG1215	transferase activity, transferring glycosyl groups
HRR28_RS08580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRR28_RS08665	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HRR28_RS08670	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HRR28_RS08690	COG3328	transposase activity
HRR28_RS08745	COG3328	transposase activity
HRR28_RS08755	COG1216	Glycosyl transferase, family 2
HRR28_RS08770	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HRR28_RS08790	COG1396	sequence-specific DNA binding
HRR28_RS08790	COG3800	Transcriptional regulator
HRR28_RS08805	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HRR28_RS08810	COG1134	teichoic acid transport
HRR28_RS08815	COG1682	transport, permease protein
HRR28_RS08825	COG3657	addiction module killer protein
HRR28_RS08835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRR28_RS08840	COG1705	Flagellar rod assembly protein muramidase FlgJ
HRR28_RS08840	COG3942	CHAP domain
HRR28_RS08865	COG2205	protein histidine kinase activity
HRR28_RS08865	COG0784	Response regulator, receiver
HRR28_RS08870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HRR28_RS08875	COG0736	holo-[acyl-carrier-protein] synthase activity
HRR28_RS08880	COG0072	phenylalanine-tRNA ligase activity
HRR28_RS08885	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HRR28_RS08905	COG0497	DNA recombination
HRR28_RS08915	COG0556	nucleotide-excision repair
HRR28_RS08930	COG1053	succinate dehydrogenase
HRR28_RS08950	COG0237	dephospho-CoA kinase activity
HRR28_RS08955	COG0539	negative regulation of cytoplasmic translation
HRR28_RS08975	COG0347	Belongs to the P(II) protein family
HRR28_RS08980	COG0004	ammonium transporteR
HRR28_RS09000	COG3301	Polysulphide reductase, NrfD
HRR28_RS09010	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS09015	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS09025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HRR28_RS09035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRR28_RS09045	COG0439	Biotin carboxylase
HRR28_RS09050	COG5016	pyruvate
HRR28_RS09050	COG0511	ligase activity, forming carbon-carbon bonds
HRR28_RS09090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRR28_RS09100	COG0243	molybdopterin cofactor binding
HRR28_RS09105	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS09110	COG3381	protein complex oligomerization
HRR28_RS09125	COG0006	proline dipeptidase activity
HRR28_RS09130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HRR28_RS09135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HRR28_RS09140	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRR28_RS09145	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HRR28_RS09155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRR28_RS09170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HRR28_RS09175	COG3853	Toxic anion resistance protein (TelA)
HRR28_RS09225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HRR28_RS09245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRR28_RS09265	COG3976	FMN-binding domain protein
HRR28_RS09265	COG1053	succinate dehydrogenase
HRR28_RS09285	COG1733	regulation of RNA biosynthetic process
HRR28_RS09320	COG4555	ABC transporter
HRR28_RS09340	COG0348	domain, Protein
HRR28_RS09355	COG0243	molybdopterin cofactor binding
HRR28_RS09360	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS09365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRR28_RS09370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HRR28_RS09395	COG0538	isocitrate dehydrogenase activity
HRR28_RS09400	COG0514	ATP-dependent DNA helicase (RecQ)
HRR28_RS09405	COG1247	-acetyltransferase
HRR28_RS09425	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HRR28_RS09435	COG0084	hydrolase, TatD family'
HRR28_RS09440	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRR28_RS09440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRR28_RS09445	COG2205	protein histidine kinase activity
HRR28_RS09445	COG0784	Response regulator, receiver
HRR28_RS09445	COG2198	Histidine kinase
HRR28_RS09450	COG1959	2 iron, 2 sulfur cluster binding
HRR28_RS09490	COG1316	TRANSCRIPTIONal
HRR28_RS09510	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS09515	COG0243	molybdopterin cofactor binding
HRR28_RS09525	COG1725	Transcriptional regulator
HRR28_RS09540	COG0288	reversible hydration of carbon dioxide
HRR28_RS09560	COG0542	response to heat
HRR28_RS09565	COG0515	serine threonine protein kinase
HRR28_RS09565	COG2815	serine threonine protein kinase
HRR28_RS09575	COG2848	UPF0210 protein
HRR28_RS09585	COG3254	rhamnose metabolic process
HRR28_RS09590	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS09595	COG0243	molybdopterin cofactor binding
HRR28_RS09615	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS09620	COG0243	molybdopterin cofactor binding
HRR28_RS09625	COG0824	Thioesterase
HRR28_RS09630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRR28_RS09635	COG2235	arginine
HRR28_RS09640	COG1288	antiporter activity
HRR28_RS09650	COG1396	sequence-specific DNA binding
HRR28_RS09655	COG3254	rhamnose metabolic process
HRR28_RS09660	COG0824	Thioesterase
HRR28_RS09685	COG2909	trisaccharide binding
HRR28_RS09690	COG0583	DNA-binding transcription factor activity
HRR28_RS09700	COG2909	trisaccharide binding
HRR28_RS09705	COG1201	RNA secondary structure unwinding
HRR28_RS09720	COG1053	succinate dehydrogenase
HRR28_RS09725	COG0789	Transcriptional regulator
HRR28_RS09750	COG3973	AAA domain
HRR28_RS09765	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HRR28_RS09770	COG1122	ATPase activity
HRR28_RS09775	COG3845	ABC transporter
HRR28_RS09790	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRR28_RS09795	COG0531	amino acid
HRR28_RS09800	COG2957	Belongs to the agmatine deiminase family
HRR28_RS09805	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HRR28_RS09830	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS09850	COG1725	Transcriptional regulator
HRR28_RS09860	COG1968	undecaprenyl-diphosphatase activity
HRR28_RS09880	COG0515	serine threonine protein kinase
HRR28_RS09880	COG2815	serine threonine protein kinase
HRR28_RS09900	COG1131	(ABC) transporter
HRR28_RS09920	COG1748	Saccharopine dehydrogenase
HRR28_RS09925	COG0825	malonyl-CoA metabolic process
HRR28_RS09925	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HRR28_RS09930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRR28_RS09945	COG1028	Short-chain dehydrogenase reductase Sdr
HRR28_RS09945	COG0604	alcohol dehydrogenase
HRR28_RS09945	COG3321	synthase
HRR28_RS09950	COG2070	2-Nitropropane dioxygenase
HRR28_RS09955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HRR28_RS09960	COG2843	Capsule synthesis protein
HRR28_RS09985	COG0560	Phosphoserine phosphatase
HRR28_RS10005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HRR28_RS10020	COG0542	response to heat
HRR28_RS10025	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS10060	COG0784	Response regulator, receiver
HRR28_RS10060	COG2205	protein histidine kinase activity
HRR28_RS10065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HRR28_RS10075	COG0482	sulfurtransferase activity
HRR28_RS10095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRR28_RS10105	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HRR28_RS10150	COG1876	peptidase activity
HRR28_RS10170	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS10175	COG2414	aldehyde ferredoxin oxidoreductase
HRR28_RS10200	COG0436	Aminotransferase
HRR28_RS10210	COG0477	Major facilitator Superfamily
HRR28_RS10215	COG1834	amidinotransferase
HRR28_RS10225	COG0477	Major facilitator Superfamily
HRR28_RS10240	COG1834	amidinotransferase
HRR28_RS10245	COG0549	Belongs to the carbamate kinase family
HRR28_RS10250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRR28_RS10255	COG2235	arginine
HRR28_RS10260	COG1228	amidohydrolase
HRR28_RS10270	COG3328	transposase activity
HRR28_RS10280	COG1401	restriction endodeoxyribonuclease activity
HRR28_RS10285	COG4268	DNA restriction-modification system
HRR28_RS10310	COG4974	Belongs to the 'phage' integrase family
HRR28_RS10340	COG0640	Transcriptional regulator
HRR28_RS10345	COG2217	Heavy metal translocating P-type atpase
HRR28_RS10350	COG2217	Heavy metal translocating P-type atpase
HRR28_RS10365	COG2197	response regulator
HRR28_RS10375	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS10380	COG0243	molybdopterin cofactor binding
HRR28_RS10390	COG0222	ribosome binding
HRR28_RS10395	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HRR28_RS10400	COG2197	response regulator
HRR28_RS10405	COG1053	succinate dehydrogenase
HRR28_RS10415	COG1487	ribonuclease activity
HRR28_RS10425	COG0124	histidyl-tRNA synthetase
HRR28_RS10430	COG0473	3-isopropylmalate dehydrogenase activity
HRR28_RS10435	COG0066	3-isopropylmalate dehydratase activity
HRR28_RS10440	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HRR28_RS10450	COG0142	geranyltranstransferase activity
HRR28_RS10465	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HRR28_RS10465	COG3976	FMN-binding domain protein
HRR28_RS10475	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS10480	COG0243	molybdopterin cofactor binding
HRR28_RS10485	COG0745	RESPONSE REGULATOR receiver
HRR28_RS10490	COG2205	protein histidine kinase activity
HRR28_RS10525	COG1918	ferrous iron import across plasma membrane
HRR28_RS10525	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HRR28_RS10625	COG1131	(ABC) transporter
HRR28_RS10640	COG0697	spore germination
HRR28_RS10680	COG2197	response regulator
HRR28_RS10755	COG1136	(ABC) transporter
HRR28_RS10760	COG5002	protein histidine kinase activity
HRR28_RS10770	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HRR28_RS10780	COG1309	transcriptional regulator
HRR28_RS10800	COG2205	protein histidine kinase activity
HRR28_RS10800	COG0784	Response regulator, receiver
HRR28_RS10805	COG0495	leucyl-tRNA aminoacylation
HRR28_RS10815	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HRR28_RS10825	COG0583	DNA-binding transcription factor activity
HRR28_RS10845	COG1592	Rubrerythrin
HRR28_RS10850	COG1362	aminopeptidase activity
HRR28_RS10855	COG0549	Belongs to the carbamate kinase family
HRR28_RS10860	COG2235	arginine
HRR28_RS10865	COG2235	arginine
HRR28_RS10870	COG2235	arginine
HRR28_RS10885	COG2957	Belongs to the agmatine deiminase family
HRR28_RS10890	COG0531	amino acid
HRR28_RS10905	COG2197	response regulator
HRR28_RS10910	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HRR28_RS10935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRR28_RS10965	COG0477	Major facilitator Superfamily
HRR28_RS10990	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS11005	COG2197	response regulator
HRR28_RS11035	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS11050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRR28_RS11055	COG0477	Major facilitator Superfamily
HRR28_RS11060	COG2233	PERMEase
HRR28_RS11070	COG2197	response regulator
HRR28_RS11090	COG0745	RESPONSE REGULATOR receiver
HRR28_RS11100	COG3850	Histidine kinase
HRR28_RS11100	COG5002	protein histidine kinase activity
HRR28_RS11170	COG2205	protein histidine kinase activity
HRR28_RS11180	COG1131	(ABC) transporter
HRR28_RS11185	COG0745	RESPONSE REGULATOR receiver
HRR28_RS11200	COG2814	Major facilitator Superfamily
HRR28_RS11205	COG0235	Class ii aldolase
HRR28_RS11210	COG1070	Carbohydrate kinase
HRR28_RS11210	COG4806	L-rhamnose isomerase
HRR28_RS11215	COG1070	Carbohydrate kinase
HRR28_RS11240	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HRR28_RS11245	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HRR28_RS11270	COG0067	glutamate synthase
HRR28_RS11275	COG0069	glutamate synthase activity
HRR28_RS11285	COG1053	succinate dehydrogenase
HRR28_RS11300	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HRR28_RS11305	COG2873	o-acetylhomoserine
HRR28_RS11370	COG1396	sequence-specific DNA binding
HRR28_RS11380	COG0460	homoserine dehydrogenase
HRR28_RS11390	COG0019	diaminopimelate decarboxylase activity
HRR28_RS11405	COG0733	neurotransmitter:sodium symporter activity
HRR28_RS11430	COG0398	Pfam SNARE associated Golgi protein
HRR28_RS11445	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRR28_RS11450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRR28_RS11465	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HRR28_RS11475	COG0515	serine threonine protein kinase
HRR28_RS11475	COG2815	serine threonine protein kinase
HRR28_RS11480	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HRR28_RS11490	COG3275	phosphorelay sensor kinase activity
HRR28_RS11495	COG0730	response to heat
HRR28_RS11505	COG1162	GTPase activity
HRR28_RS11515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRR28_RS11520	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HRR28_RS11525	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HRR28_RS11535	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HRR28_RS11540	COG5002	protein histidine kinase activity
HRR28_RS11545	COG0745	RESPONSE REGULATOR receiver
HRR28_RS11555	COG1472	Belongs to the glycosyl hydrolase 3 family
HRR28_RS11560	COG0785	Cytochrome C biogenesis protein
HRR28_RS11570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRR28_RS11575	COG1053	succinate dehydrogenase
HRR28_RS11625	COG2239	Acts as a magnesium transporter
HRR28_RS11635	COG1959	2 iron, 2 sulfur cluster binding
HRR28_RS11640	COG1757	Na H antiporter
HRR28_RS11645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRR28_RS11660	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HRR28_RS11665	COG1169	isochorismate synthase
HRR28_RS11710	COG3830	Belongs to the UPF0237 family
HRR28_RS11715	COG0302	gtp cyclohydrolase
HRR28_RS11735	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS11740	COG0243	molybdopterin cofactor binding
HRR28_RS11750	COG0708	Exodeoxyribonuclease III
HRR28_RS11755	COG1316	TRANSCRIPTIONal
HRR28_RS11760	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HRR28_RS11770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HRR28_RS11790	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS11795	COG0243	molybdopterin cofactor binding
HRR28_RS11800	COG0583	DNA-binding transcription factor activity
HRR28_RS11810	COG1053	succinate dehydrogenase
HRR28_RS11835	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HRR28_RS11840	COG3189	MarR family transcriptional regulator
HRR28_RS11845	COG2233	PERMEase
HRR28_RS11850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRR28_RS11870	COG3447	MASE1 domain protein
HRR28_RS11870	COG5001	Diguanylate cyclase
HRR28_RS11870	COG5002	protein histidine kinase activity
HRR28_RS11890	COG0025	NhaP-type Na H and K H
HRR28_RS11895	COG0519	Catalyzes the synthesis of GMP from XMP
HRR28_RS11905	COG1396	sequence-specific DNA binding
HRR28_RS11945	COG0456	acetyltransferase
HRR28_RS11955	COG0477	Major facilitator Superfamily
HRR28_RS11965	COG2066	Belongs to the glutaminase family
HRR28_RS11970	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HRR28_RS11980	COG1715	Restriction endonuclease
HRR28_RS12020	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HRR28_RS12025	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HRR28_RS12040	COG1307	EDD domain protein, DegV family
HRR28_RS12045	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HRR28_RS12060	COG0437	4 iron, 4 sulfur cluster binding
HRR28_RS12065	COG0243	molybdopterin cofactor binding
HRR28_RS12080	COG1393	Belongs to the ArsC family
HRR28_RS12090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HRR28_RS12120	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HRR28_RS12140	COG0531	amino acid
HRR28_RS12160	COG2223	nitrite transmembrane transporter activity
HRR28_RS12190	COG0431	NADPH-dependent FMN reductase
HRR28_RS12190	COG1053	succinate dehydrogenase
HRR28_RS12190	COG3976	FMN-binding domain protein
HRR28_RS12195	COG3976	FMN-binding domain protein
HRR28_RS12195	COG1053	succinate dehydrogenase
HRR28_RS12195	COG0431	NADPH-dependent FMN reductase
HRR28_RS12215	COG1120	ATPase activity
HRR28_RS12230	COG0745	RESPONSE REGULATOR receiver
HRR28_RS12235	COG2205	protein histidine kinase activity
HRR28_RS12250	COG1733	regulation of RNA biosynthetic process
HRR28_RS12270	COG0433	COG0433 Predicted ATPase
HRR28_RS12275	COG0390	transport system, permease component
HRR28_RS12280	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRR28_RS12375	COG0318	PFAM AMP-dependent synthetase and ligase