locus-tag	class	description
ISU00_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ISU00_RS00010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISU00_RS00015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ISU00_RS00040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ISU00_RS00045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU00_RS00060	COG0336	Belongs to the RNA methyltransferase TrmD family
ISU00_RS00065	COG0335	large ribosomal subunit rRNA binding
ISU00_RS00085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ISU00_RS00110	COG3292	Two component regulator propeller
ISU00_RS00110	COG2205	protein histidine kinase activity
ISU00_RS00110	COG0745	RESPONSE REGULATOR receiver
ISU00_RS00110	COG2205	protein histidine kinase activity
ISU00_RS00110	COG0745	RESPONSE REGULATOR receiver
ISU00_RS00110	COG3292	Two component regulator propeller
ISU00_RS00120	COG0673	inositol 2-dehydrogenase activity
ISU00_RS00160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ISU00_RS00165	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ISU00_RS00170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ISU00_RS00175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ISU00_RS00220	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ISU00_RS00230	COG0628	permease
ISU00_RS00235	COG0305	Participates in initiation and elongation during chromosome replication
ISU00_RS00240	COG0825	malonyl-CoA metabolic process
ISU00_RS00255	COG0343	queuine tRNA-ribosyltransferase activity
ISU00_RS00265	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ISU00_RS00280	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISU00_RS00285	COG0500	methyltransferase
ISU00_RS00290	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ISU00_RS00295	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISU00_RS00310	COG0789	Transcriptional regulator
ISU00_RS00315	COG1233	COG1233 Phytoene dehydrogenase and related
ISU00_RS00335	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ISU00_RS00345	COG0714	Associated with various cellular activities
ISU00_RS00395	COG0366	Alpha amylase catalytic
ISU00_RS00405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU00_RS00405	COG3153	acetyltransferase
ISU00_RS00415	COG0516	GMP reductase activity
ISU00_RS00415	COG0517	IMP dehydrogenase activity
ISU00_RS00435	COG0167	dihydroorotate dehydrogenase activity
ISU00_RS00440	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISU00_RS00450	COG3258	Cytochrome c
ISU00_RS00465	COG1862	Preprotein translocase
ISU00_RS00475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISU00_RS00485	COG1132	(ABC) transporter
ISU00_RS00500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISU00_RS00545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISU00_RS00550	COG0339	signal peptide processing
ISU00_RS00560	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ISU00_RS00615	COG0714	Associated with various cellular activities
ISU00_RS00625	COG0783	Belongs to the Dps family
ISU00_RS00680	COG0492	ferredoxin-NADP+ reductase activity
ISU00_RS00700	COG4977	sequence-specific DNA binding
ISU00_RS00700	COG1917	Cupin 2, conserved barrel domain protein
ISU00_RS00755	COG1012	belongs to the aldehyde dehydrogenase family
ISU00_RS00790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISU00_RS00795	COG2217	Heavy metal translocating P-type atpase
ISU00_RS00835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISU00_RS00845	COG2115	Belongs to the xylose isomerase family
ISU00_RS00855	COG1609	Transcriptional regulator
ISU00_RS00860	COG3661	Belongs to the glycosyl hydrolase 67 family
ISU00_RS00865	COG1028	Short-chain dehydrogenase reductase Sdr
ISU00_RS00880	COG3693	PFAM glycoside hydrolase, family 10
ISU00_RS00880	COG3507	Belongs to the glycosyl hydrolase 43 family
ISU00_RS00880	COG2382	esterase
ISU00_RS00890	COG2133	pyrroloquinoline quinone binding
ISU00_RS00905	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISU00_RS00910	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISU00_RS00910	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISU00_RS00915	COG1192	Involved in chromosome partitioning
ISU00_RS00920	COG1475	DNA binding
ISU00_RS00930	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ISU00_RS00935	COG0681	Belongs to the peptidase S26 family
ISU00_RS00965	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ISU00_RS00980	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ISU00_RS00990	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISU00_RS01015	COG0105	UTP biosynthetic process
ISU00_RS01020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ISU00_RS01030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISU00_RS01035	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISU00_RS01055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU00_RS01060	COG0501	Belongs to the peptidase M48B family
ISU00_RS01065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ISU00_RS01070	COG0154	amidase activity
ISU00_RS01075	COG0552	protein localization to endoplasmic reticulum
ISU00_RS01085	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ISU00_RS01090	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ISU00_RS01095	COG1546	Belongs to the CinA family
ISU00_RS01095	COG1058	Belongs to the CinA family
ISU00_RS01105	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISU00_RS01110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISU00_RS01115	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU00_RS01120	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ISU00_RS01120	COG1215	transferase activity, transferring glycosyl groups
ISU00_RS01125	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ISU00_RS01145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU00_RS01150	COG1506	peptidase
ISU00_RS01155	COG0326	Molecular chaperone. Has ATPase activity
ISU00_RS01160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ISU00_RS01180	COG1595	DNA-templated transcription, initiation
ISU00_RS01200	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ISU00_RS01240	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ISU00_RS01285	COG0085	RNA polymerase activity
ISU00_RS01290	COG0222	ribosome binding
ISU00_RS01295	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ISU00_RS01300	COG0081	regulation of translation
ISU00_RS01305	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ISU00_RS01350	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISU00_RS01355	COG4974	Belongs to the 'phage' integrase family
ISU00_RS01360	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ISU00_RS01365	COG1960	acyl-CoA dehydrogenase activity
ISU00_RS01375	COG1115	amino acid carrier protein
ISU00_RS01415	COG3876	Protein conserved in bacteria
ISU00_RS01445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISU00_RS01465	COG2884	Cell division ATP-binding protein ftsE
ISU00_RS01505	COG2244	polysaccharide biosynthetic process
ISU00_RS01510	COG2244	polysaccharide biosynthetic process
ISU00_RS01525	COG1217	gtp-binding protein TYPA
ISU00_RS01530	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ISU00_RS01535	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISU00_RS01550	COG0187	DNA topoisomerase II activity
ISU00_RS01555	COG0367	asparagine synthase
ISU00_RS01565	COG0602	queuosine metabolic process
ISU00_RS01570	COG0433	COG0433 Predicted ATPase
ISU00_RS01580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ISU00_RS01585	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ISU00_RS01585	COG0662	Cupin 2, conserved barrel domain protein
ISU00_RS01590	COG0596	Alpha beta hydrolase
ISU00_RS01595	COG1187	pseudouridine synthase activity
ISU00_RS01615	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ISU00_RS01620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISU00_RS01630	COG0018	arginyl-trna synthetase
ISU00_RS01635	COG4251	negative regulation of phosphorylation
ISU00_RS01650	COG1051	belongs to the nudix hydrolase family
ISU00_RS01655	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ISU00_RS01665	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ISU00_RS01665	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ISU00_RS01670	COG0799	negative regulation of ribosome biogenesis
ISU00_RS01675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISU00_RS01685	COG4589	Belongs to the CDS family
ISU00_RS01690	COG0688	phosphatidylethanolamine metabolic process
ISU00_RS01700	COG1834	amidinotransferase
ISU00_RS01705	COG0372	Belongs to the citrate synthase family
ISU00_RS01710	COG0148	phosphopyruvate hydratase activity
ISU00_RS01715	COG0505	Belongs to the CarA family
ISU00_RS01720	COG0203	ribosomal protein L17
ISU00_RS01725	COG0202	RNA polymerase activity
ISU00_RS01730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ISU00_RS01735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ISU00_RS01740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ISU00_RS01745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISU00_RS01750	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ISU00_RS01755	COG0201	protein transport
ISU00_RS01760	COG0200	Binds to the 23S rRNA
ISU00_RS01765	COG1841	ribosomal large subunit assembly
ISU00_RS01770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ISU00_RS01775	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ISU00_RS01780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ISU00_RS01785	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ISU00_RS01790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ISU00_RS01795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ISU00_RS01800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ISU00_RS01805	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ISU00_RS01810	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISU00_RS01815	COG0255	Belongs to the universal ribosomal protein uL29 family
ISU00_RS01820	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ISU00_RS01825	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ISU00_RS01830	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ISU00_RS01835	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ISU00_RS01840	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ISU00_RS01845	COG0089	rRNA binding
ISU00_RS01850	COG0088	Forms part of the polypeptide exit tunnel
ISU00_RS01855	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ISU00_RS01860	COG0051	transcription antitermination factor activity, RNA binding
ISU00_RS01865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISU00_RS01870	COG0049	tRNA binding
ISU00_RS01875	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ISU00_RS01885	COG4771	TonB-dependent receptor
ISU00_RS01900	COG4771	TonB-dependent receptor
ISU00_RS01915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU00_RS01925	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISU00_RS01945	COG2003	Belongs to the UPF0758 family
ISU00_RS01955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISU00_RS01965	COG4206	TonB-dependent receptor
ISU00_RS01965	COG1629	transport
ISU00_RS01970	COG0300	oxidoreductase activity
ISU00_RS01980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ISU00_RS01985	COG0563	adenylate kinase activity
ISU00_RS01990	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ISU00_RS01995	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ISU00_RS02015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISU00_RS02015	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISU00_RS02020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU00_RS02035	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
ISU00_RS02040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISU00_RS02045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISU00_RS02065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU00_RS02085	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU00_RS02090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ISU00_RS02095	COG0295	cytidine deaminase activity
ISU00_RS02110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ISU00_RS02115	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISU00_RS02160	COG0848	biopolymer transport protein
ISU00_RS02165	COG0811	peptide transport
ISU00_RS02175	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ISU00_RS02180	COG1960	acyl-CoA dehydrogenase activity
ISU00_RS02215	COG0702	epimerase
ISU00_RS02220	COG4771	TonB-dependent receptor
ISU00_RS02230	COG4771	TonB-dependent receptor
ISU00_RS02235	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ISU00_RS02245	COG0321	lipoyl(octanoyl) transferase activity
ISU00_RS02250	COG0401	homolog of Blt101
ISU00_RS02255	COG2197	response regulator
ISU00_RS02265	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ISU00_RS02290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ISU00_RS02295	COG1388	LysM domain
ISU00_RS02295	COG3103	Sh3 type 3 domain protein
ISU00_RS02295	COG0791	NLP P60 protein
ISU00_RS02320	COG0659	secondary active sulfate transmembrane transporter activity
ISU00_RS02325	COG0022	dehydrogenase e1 component
ISU00_RS02330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISU00_RS02335	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU00_RS02340	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISU00_RS02350	COG1012	belongs to the aldehyde dehydrogenase family
ISU00_RS02350	COG2030	dehydratase
ISU00_RS02355	COG0183	Belongs to the thiolase family
ISU00_RS02360	COG2050	protein possibly involved in aromatic compounds catabolism
ISU00_RS02365	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISU00_RS02370	COG1024	Enoyl-CoA hydratase
ISU00_RS02380	COG2151	metal-sulfur cluster biosynthetic enzyme
ISU00_RS02385	COG3396	Phenylacetate-CoA oxygenase
ISU00_RS02390	COG3460	Phenylacetate-CoA oxygenase
ISU00_RS02395	COG3396	Phenylacetate-CoA oxygenase
ISU00_RS02400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU00_RS02405	COG1309	transcriptional regulator
ISU00_RS02410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISU00_RS02430	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISU00_RS02435	COG2197	response regulator
ISU00_RS02440	COG0358	DNA primase activity
ISU00_RS02470	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ISU00_RS02475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ISU00_RS02480	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ISU00_RS02490	COG1490	D-aminoacyl-tRNA deacylase activity
ISU00_RS02495	COG1162	GTPase activity
ISU00_RS02500	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ISU00_RS02505	COG0287	Prephenate dehydrogenase
ISU00_RS02510	COG0436	Aminotransferase
ISU00_RS02515	COG0077	Prephenate dehydratase
ISU00_RS02535	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ISU00_RS02545	COG0646	methionine synthase
ISU00_RS02545	COG1410	methionine synthase
ISU00_RS02555	COG1045	serine acetyltransferase
ISU00_RS02560	COG0492	ferredoxin-NADP+ reductase activity
ISU00_RS02565	COG1648	precorrin-2 dehydrogenase activity
ISU00_RS02565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ISU00_RS02570	COG1648	precorrin-2 dehydrogenase activity
ISU00_RS02570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ISU00_RS02575	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISU00_RS02580	COG0175	sulfate reduction
ISU00_RS02585	COG1959	2 iron, 2 sulfur cluster binding
ISU00_RS02600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISU00_RS02605	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ISU00_RS02610	COG0066	3-isopropylmalate dehydratase activity
ISU00_RS02615	COG0473	3-isopropylmalate dehydrogenase activity
ISU00_RS02625	COG3279	Response regulator of the LytR AlgR family
ISU00_RS02645	COG0165	Argininosuccinate lyase
ISU00_RS02650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISU00_RS02655	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ISU00_RS02660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ISU00_RS02665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISU00_RS02670	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISU00_RS02675	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISU00_RS02680	COG0137	argininosuccinate synthase activity
ISU00_RS02700	COG1082	Xylose isomerase domain protein TIM barrel
ISU00_RS02705	COG0673	inositol 2-dehydrogenase activity
ISU00_RS02710	COG2211	Major facilitator Superfamily
ISU00_RS02745	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISU00_RS02750	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ISU00_RS02755	COG0440	acetolactate synthase activity
ISU00_RS02760	COG0028	Belongs to the TPP enzyme family
ISU00_RS02765	COG0129	dihydroxy-acid dehydratase activity
ISU00_RS02775	COG0070	glutamate synthase
ISU00_RS02775	COG0067	glutamate synthase
ISU00_RS02775	COG0069	glutamate synthase activity
ISU00_RS02785	COG0347	Belongs to the P(II) protein family
ISU00_RS02790	COG0004	ammonium transporteR
ISU00_RS02795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ISU00_RS02845	COG1428	Deoxynucleoside kinase
ISU00_RS02850	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISU00_RS02860	COG3174	membrane
ISU00_RS02865	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ISU00_RS02885	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU00_RS02885	COG0022	dehydrogenase e1 component
ISU00_RS02890	COG2086	electron transfer activity
ISU00_RS02895	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ISU00_RS02905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISU00_RS02910	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ISU00_RS02920	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ISU00_RS02925	COG0110	maltose O-acetyltransferase activity
ISU00_RS02945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ISU00_RS02955	COG1519	Transferase
ISU00_RS02970	COG4181	ATPase activity
ISU00_RS02985	COG1312	Catalyzes the dehydration of D-mannonate
ISU00_RS02990	COG1917	Cupin 2, conserved barrel domain protein
ISU00_RS03000	COG2755	lipolytic protein G-D-S-L family
ISU00_RS03005	COG0657	acetylesterase activity
ISU00_RS03005	COG2755	lipolytic protein G-D-S-L family
ISU00_RS03010	COG2755	lipolytic protein G-D-S-L family
ISU00_RS03020	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ISU00_RS03040	COG2721	sulfolactate sulfo-lyase activity
ISU00_RS03045	COG0246	Mannitol dehydrogenase
ISU00_RS03055	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ISU00_RS03065	COG0800	Aldolase
ISU00_RS03075	COG1904	glucuronate isomerase
ISU00_RS03080	COG1028	Short-chain dehydrogenase reductase Sdr
ISU00_RS03085	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ISU00_RS03095	COG0702	epimerase
ISU00_RS03100	COG4771	TonB-dependent receptor
ISU00_RS03110	COG2133	pyrroloquinoline quinone binding
ISU00_RS03125	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ISU00_RS03130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU00_RS03135	COG1428	Deoxynucleoside kinase
ISU00_RS03150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISU00_RS03155	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ISU00_RS03170	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ISU00_RS03180	COG0544	peptidyl-prolyl cis-trans isomerase activity
ISU00_RS03185	COG1950	PFAM Membrane protein of
ISU00_RS03190	COG0596	Alpha beta hydrolase
ISU00_RS03195	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISU00_RS03205	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ISU00_RS03215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ISU00_RS03235	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ISU00_RS03240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISU00_RS03250	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ISU00_RS03255	COG3360	Dodecin
ISU00_RS03260	COG0668	transmembrane transport
ISU00_RS03265	COG1214	PFAM Peptidase M22, glycoprotease
ISU00_RS03280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU00_RS03285	COG1136	(ABC) transporter
ISU00_RS03285	COG0577	efflux transmembrane transporter activity
ISU00_RS03290	COG0577	efflux transmembrane transporter activity
ISU00_RS03290	COG1136	(ABC) transporter
ISU00_RS03295	COG1136	(ABC) transporter
ISU00_RS03305	COG2322	membrane
ISU00_RS03310	COG1999	signal sequence binding
ISU00_RS03330	COG1845	cytochrome c oxidase, subunit III
ISU00_RS03335	COG0109	protoheme IX farnesyltransferase activity
ISU00_RS03355	COG0509	glycine decarboxylation via glycine cleavage system
ISU00_RS03365	COG0632	four-way junction helicase activity
ISU00_RS03380	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISU00_RS03395	COG2255	four-way junction helicase activity
ISU00_RS03400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISU00_RS03405	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISU00_RS03425	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ISU00_RS03425	COG3743	rRNA binding
ISU00_RS03430	COG0437	4 iron, 4 sulfur cluster binding
ISU00_RS03445	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ISU00_RS03450	COG0195	Participates in both transcription termination and antitermination
ISU00_RS03455	COG0779	Required for maturation of 30S ribosomal subunits
ISU00_RS03460	COG1785	Belongs to the alkaline phosphatase family
ISU00_RS03475	COG0726	polysaccharide deacetylase
ISU00_RS03480	COG3118	belongs to the thioredoxin family
ISU00_RS03485	COG1408	metallophosphoesterase
ISU00_RS03490	COG3142	Participates in the control of copper homeostasis
ISU00_RS03495	COG1446	asparaginase
ISU00_RS03510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISU00_RS03510	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISU00_RS03525	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ISU00_RS03530	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ISU00_RS03535	COG0052	Belongs to the universal ribosomal protein uS2 family
ISU00_RS03540	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ISU00_RS03545	COG0528	UMP kinase activity
ISU00_RS03550	COG0233	cytoplasmic translational termination
ISU00_RS03565	COG0017	Asparaginyl-tRNA synthetase
ISU00_RS03600	COG0811	peptide transport
ISU00_RS03610	COG0252	asparaginase activity
ISU00_RS03615	COG0084	hydrolase, TatD family'
ISU00_RS03630	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU00_RS03635	COG0567	Dehydrogenase, E1 component
ISU00_RS03655	COG1309	transcriptional regulator
ISU00_RS03675	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ISU00_RS03690	COG1278	Cold shock
ISU00_RS03700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ISU00_RS03710	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ISU00_RS03715	COG4771	TonB-dependent receptor
ISU00_RS03745	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISU00_RS03745	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ISU00_RS03755	COG3279	Response regulator of the LytR AlgR family
ISU00_RS03760	COG3275	phosphorelay sensor kinase activity
ISU00_RS03770	COG2095	MarC family integral membrane protein
ISU00_RS03780	COG0492	ferredoxin-NADP+ reductase activity
ISU00_RS03800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ISU00_RS03810	COG1137	ATPase activity
ISU00_RS03820	COG0596	Alpha beta hydrolase
ISU00_RS03825	COG2226	methyltransferase
ISU00_RS03835	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISU00_RS03840	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ISU00_RS03845	COG0193	aminoacyl-tRNA hydrolase activity
ISU00_RS03855	COG0196	riboflavin kinase activity
ISU00_RS03865	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ISU00_RS03880	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISU00_RS03885	COG2239	Acts as a magnesium transporter
ISU00_RS03890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISU00_RS03910	COG0640	Transcriptional regulator
ISU00_RS03920	COG0045	succinate-CoA ligase (ADP-forming) activity
ISU00_RS03920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU00_RS03920	COG1042	CoA-binding domain protein
ISU00_RS03930	COG0527	aspartate kinase activity
ISU00_RS03940	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ISU00_RS03960	COG1652	LysM domain
ISU00_RS03980	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ISU00_RS03995	COG0659	secondary active sulfate transmembrane transporter activity
ISU00_RS04015	COG0659	secondary active sulfate transmembrane transporter activity
ISU00_RS04040	COG2304	oxidoreductase activity
ISU00_RS04045	COG0655	NAD(P)H dehydrogenase (quinone) activity
ISU00_RS04050	COG2304	oxidoreductase activity
ISU00_RS04065	COG0714	Associated with various cellular activities
ISU00_RS04080	COG4989	oxidoreductase activity
ISU00_RS04085	COG4221	oxidoreductase activity
ISU00_RS04095	COG1012	belongs to the aldehyde dehydrogenase family
ISU00_RS04100	COG1446	asparaginase
ISU00_RS04145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISU00_RS04165	COG2151	metal-sulfur cluster biosynthetic enzyme
ISU00_RS04170	COG2166	iron-sulfur cluster assembly
ISU00_RS04180	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISU00_RS04185	COG0719	Fe-S assembly protein
ISU00_RS04190	COG0396	ATPase activity
ISU00_RS04200	COG0719	Fe-S assembly protein
ISU00_RS04205	COG0316	Belongs to the HesB IscA family
ISU00_RS04210	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISU00_RS04220	COG2267	carboxylic ester hydrolase activity
ISU00_RS04225	COG0006	proline dipeptidase activity
ISU00_RS04245	COG1053	succinate dehydrogenase
ISU00_RS04250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISU00_RS04255	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ISU00_RS04260	COG4717	serine-type aminopeptidase activity
ISU00_RS04265	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ISU00_RS04270	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ISU00_RS04280	COG0612	Peptidase, M16
ISU00_RS04285	COG0612	Peptidase, M16
ISU00_RS04290	COG2217	Heavy metal translocating P-type atpase
ISU00_RS04300	COG2954	triphosphatase activity
ISU00_RS04305	COG0702	epimerase
ISU00_RS04310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ISU00_RS04315	COG0469	pyruvate kinase activity
ISU00_RS04325	COG0571	ribonuclease III activity
ISU00_RS04330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU00_RS04335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISU00_RS04345	COG0328	RNA-DNA hybrid ribonuclease activity
ISU00_RS04345	COG3341	Caulimovirus viroplasmin
ISU00_RS04365	COG1074	ATP-dependent DNA helicase activity
ISU00_RS04370	COG0156	8-amino-7-oxononanoate synthase activity
ISU00_RS04375	COG2885	chlorophyll binding
ISU00_RS04385	COG0644	oxidoreductase
ISU00_RS04395	COG1028	Short-chain dehydrogenase reductase Sdr
ISU00_RS04415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU00_RS04420	COG4106	trans-aconitate 2-methyltransferase activity
ISU00_RS04430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISU00_RS04435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU00_RS04445	COG0726	polysaccharide deacetylase
ISU00_RS04480	COG1215	transferase activity, transferring glycosyl groups
ISU00_RS04485	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ISU00_RS04495	COG0798	PFAM Bile acid sodium symporter
ISU00_RS04510	COG0393	Putative heavy-metal-binding
ISU00_RS04575	COG0720	synthase
ISU00_RS04580	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISU00_RS04585	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ISU00_RS04595	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ISU00_RS04595	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISU00_RS04605	COG4206	TonB-dependent receptor
ISU00_RS04605	COG1629	transport
ISU00_RS04615	COG0156	8-amino-7-oxononanoate synthase activity
ISU00_RS04620	COG4948	Mandelate Racemase Muconate Lactonizing
ISU00_RS04630	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ISU00_RS04640	COG1435	thymidine kinase activity
ISU00_RS04645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ISU00_RS04650	COG1970	mechanosensitive ion channel activity
ISU00_RS04655	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISU00_RS04670	COG1505	serine-type exopeptidase activity
ISU00_RS04675	COG3842	ATPase activity
ISU00_RS04685	COG0439	Biotin carboxylase
ISU00_RS04690	COG0511	ligase activity, forming carbon-carbon bonds
ISU00_RS04695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU00_RS04700	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ISU00_RS04710	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISU00_RS04715	COG0307	riboflavin synthase, alpha
ISU00_RS04730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISU00_RS04730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU00_RS04740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU00_RS04745	COG0469	pyruvate kinase activity
ISU00_RS04770	COG0738	Major facilitator superfamily
ISU00_RS04785	COG1063	alcohol dehydrogenase
ISU00_RS04790	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISU00_RS04800	COG1028	Short-chain dehydrogenase reductase Sdr
ISU00_RS04820	COG2274	protein secretion by the type I secretion system
ISU00_RS04860	COG0154	amidase activity
ISU00_RS04925	COG2755	lipolytic protein G-D-S-L family
ISU00_RS04925	COG0657	acetylesterase activity
ISU00_RS04935	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ISU00_RS04955	COG4771	TonB-dependent receptor
ISU00_RS04975	COG3254	rhamnose metabolic process
ISU00_RS04995	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ISU00_RS05005	COG2755	lipolytic protein G-D-S-L family
ISU00_RS05010	COG3250	beta-galactosidase activity
ISU00_RS05015	COG2755	lipolytic protein G-D-S-L family
ISU00_RS05020	COG4771	TonB-dependent receptor
ISU00_RS05030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISU00_RS05035	COG3347	Dehydrogenase
ISU00_RS05035	COG1028	Short-chain dehydrogenase reductase Sdr
ISU00_RS05040	COG4952	isomerase
ISU00_RS05050	COG1304	FMN binding
ISU00_RS05090	COG1994	Peptidase M50
ISU00_RS05105	COG0071	Belongs to the small heat shock protein (HSP20) family
ISU00_RS05110	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISU00_RS05125	COG0589	response to stress
ISU00_RS05135	COG0745	RESPONSE REGULATOR receiver
ISU00_RS05140	COG5002	protein histidine kinase activity
ISU00_RS05175	COG3408	Glycogen debranching enzyme
ISU00_RS05180	COG2205	protein histidine kinase activity
ISU00_RS05180	COG3292	Two component regulator propeller
ISU00_RS05180	COG0745	RESPONSE REGULATOR receiver
ISU00_RS05185	COG4771	TonB-dependent receptor
ISU00_RS05190	COG0702	epimerase
ISU00_RS05195	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU00_RS05200	COG3119	arylsulfatase activity
ISU00_RS05205	COG3119	arylsulfatase activity
ISU00_RS05210	COG3119	arylsulfatase activity
ISU00_RS05230	COG3119	arylsulfatase activity
ISU00_RS05240	COG3693	PFAM glycoside hydrolase, family 10
ISU00_RS05245	COG3119	arylsulfatase activity
ISU00_RS05250	COG3119	arylsulfatase activity
ISU00_RS05270	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISU00_RS05285	COG3940	Belongs to the glycosyl hydrolase 43 family
ISU00_RS05295	COG3250	beta-galactosidase activity
ISU00_RS05300	COG3345	alpha-galactosidase
ISU00_RS05320	COG3250	beta-galactosidase activity
ISU00_RS05345	COG0702	epimerase
ISU00_RS05350	COG4771	TonB-dependent receptor
ISU00_RS05355	COG2205	protein histidine kinase activity
ISU00_RS05355	COG3292	Two component regulator propeller
ISU00_RS05355	COG0745	RESPONSE REGULATOR receiver
ISU00_RS05360	COG4771	TonB-dependent receptor
ISU00_RS05400	COG2814	Major facilitator Superfamily
ISU00_RS05400	COG0477	Major facilitator Superfamily
ISU00_RS05405	COG3250	beta-galactosidase activity
ISU00_RS05410	COG0457	Tetratricopeptide repeat
ISU00_RS05420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ISU00_RS05430	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ISU00_RS05435	COG4263	nitrous-oxide reductase activity
ISU00_RS05475	COG1959	2 iron, 2 sulfur cluster binding
ISU00_RS05495	COG2217	Heavy metal translocating P-type atpase
ISU00_RS05510	COG2132	Multicopper oxidase
ISU00_RS05550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU00_RS05555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU00_RS05560	COG1538	Outer membrane efflux protein
ISU00_RS05610	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISU00_RS05610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISU00_RS05645	COG0346	lactoylglutathione lyase activity
ISU00_RS05650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ISU00_RS05665	COG2234	aminopeptidase activity
ISU00_RS05680	COG0481	GTPase activity
ISU00_RS05690	COG3263	regulation of cellular component size
ISU00_RS05695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU00_RS05710	COG2988	succinylglutamate desuccinylase activity
ISU00_RS05715	COG0517	IMP dehydrogenase activity
ISU00_RS05715	COG0617	tRNA 3'-terminal CCA addition
ISU00_RS05715	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ISU00_RS05720	COG0594	ribonuclease P activity
ISU00_RS05725	COG0793	Belongs to the peptidase S41A family
ISU00_RS05745	COG0557	exoribonuclease II activity
ISU00_RS05765	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISU00_RS05820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISU00_RS05830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ISU00_RS05835	COG0445	tRNA wobble uridine modification
ISU00_RS05850	COG0470	DNA polymerase III
ISU00_RS05855	COG0126	phosphoglycerate kinase activity
ISU00_RS05860	COG1388	LysM domain
ISU00_RS05860	COG1705	Flagellar rod assembly protein muramidase FlgJ
ISU00_RS05870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISU00_RS05905	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ISU00_RS05915	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
ISU00_RS05920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU00_RS05925	COG1218	3'(2'),5'-bisphosphate nucleotidase
ISU00_RS05935	COG0529	Catalyzes the synthesis of activated sulfate
ISU00_RS05940	COG0175	sulfate reduction
ISU00_RS05980	COG0110	maltose O-acetyltransferase activity
ISU00_RS06020	COG0151	Belongs to the GarS family
ISU00_RS06035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ISU00_RS06050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU00_RS06080	COG0356	it plays a direct role in the translocation of protons across the membrane
ISU00_RS06085	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ISU00_RS06090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ISU00_RS06095	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ISU00_RS06100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ISU00_RS06105	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ISU00_RS06115	COG0756	dUTP diphosphatase activity
ISU00_RS06120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISU00_RS06150	COG0758	DNA mediated transformation
ISU00_RS06155	COG0180	Tryptophanyl-tRNA synthetase
ISU00_RS06180	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ISU00_RS06190	COG0826	peptidase U32
ISU00_RS06205	COG1774	PSP1 C-terminal conserved region
ISU00_RS06215	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISU00_RS06220	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ISU00_RS06240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISU00_RS06245	COG1253	flavin adenine dinucleotide binding
ISU00_RS06250	COG0113	porphobilinogen synthase activity
ISU00_RS06255	COG0408	coproporphyrinogen oxidase activity
ISU00_RS06265	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ISU00_RS06270	COG0181	hydroxymethylbilane synthase activity
ISU00_RS06275	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ISU00_RS06285	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ISU00_RS06300	COG1981	membrane
ISU00_RS06310	COG1024	Enoyl-CoA hydratase
ISU00_RS06350	COG2169	Transcriptional regulator
ISU00_RS06355	COG1418	mRNA catabolic process
ISU00_RS06370	COG0484	heat shock protein binding
ISU00_RS06395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU00_RS06400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU00_RS06405	COG1121	(ABC) transporter
ISU00_RS06410	COG0803	Belongs to the bacterial solute-binding protein 9 family
ISU00_RS06425	COG0823	Involved in the tonB-independent uptake of proteins
ISU00_RS06445	COG1999	signal sequence binding
ISU00_RS06485	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISU00_RS06740	COG0494	nUDIX hydrolase
ISU00_RS06785	COG3852	Histidine kinase
ISU00_RS06805	COG1525	nuclease
ISU00_RS06815	COG2124	cytochrome p450
ISU00_RS06820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU00_RS06850	COG3239	Fatty acid desaturase
ISU00_RS06860	COG0596	Alpha beta hydrolase
ISU00_RS06865	COG0318	PFAM AMP-dependent synthetase and ligase
ISU00_RS06870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU00_RS06885	COG0673	inositol 2-dehydrogenase activity
ISU00_RS06910	COG3275	phosphorelay sensor kinase activity
ISU00_RS06915	COG3279	Response regulator of the LytR AlgR family
ISU00_RS06920	COG1629	transport
ISU00_RS06955	COG2068	MobA-Related Protein
ISU00_RS06960	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ISU00_RS06970	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU00_RS06975	COG1501	Belongs to the glycosyl hydrolase 31 family
ISU00_RS06980	COG3250	beta-galactosidase activity
ISU00_RS06985	COG3507	Belongs to the glycosyl hydrolase 43 family
ISU00_RS07020	COG1285	pathogenesis
ISU00_RS07025	COG2379	hydroxypyruvate reductase
ISU00_RS07030	COG0401	homolog of Blt101
ISU00_RS07045	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ISU00_RS07050	COG1960	acyl-CoA dehydrogenase activity
ISU00_RS07065	COG0671	phosphoesterase, PA-phosphatase related
ISU00_RS07100	COG0398	Pfam SNARE associated Golgi protein
ISU00_RS07110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISU00_RS07150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISU00_RS07160	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ISU00_RS07165	COG1595	DNA-templated transcription, initiation
ISU00_RS07190	COG0746	molybdenum cofactor guanylyltransferase activity
ISU00_RS07195	COG0303	'Molybdopterin
ISU00_RS07200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU00_RS07200	COG0730	response to heat
ISU00_RS07215	COG0315	cyclic pyranopterin monophosphate synthase activity
ISU00_RS07215	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISU00_RS07225	COG2382	esterase
ISU00_RS07230	COG3507	Belongs to the glycosyl hydrolase 43 family
ISU00_RS07245	COG0673	inositol 2-dehydrogenase activity
ISU00_RS07280	COG0460	homoserine dehydrogenase
ISU00_RS07280	COG0527	aspartate kinase activity
ISU00_RS07285	COG0673	inositol 2-dehydrogenase activity
ISU00_RS07290	COG3119	arylsulfatase activity
ISU00_RS07295	COG3119	arylsulfatase activity
ISU00_RS07300	COG3119	arylsulfatase activity
ISU00_RS07305	COG3119	arylsulfatase activity
ISU00_RS07320	COG3938	Belongs to the proline racemase family
ISU00_RS07335	COG4977	sequence-specific DNA binding
ISU00_RS07335	COG1917	Cupin 2, conserved barrel domain protein
ISU00_RS07350	COG0402	S-adenosylhomocysteine deaminase activity
ISU00_RS07360	COG1793	dna ligase
ISU00_RS07380	COG1609	Transcriptional regulator
ISU00_RS07405	COG1082	Xylose isomerase domain protein TIM barrel
ISU00_RS07440	COG1629	transport
ISU00_RS07440	COG4206	TonB-dependent receptor
ISU00_RS07445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU00_RS07455	COG3590	peptidase
ISU00_RS07465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU00_RS07470	COG0517	IMP dehydrogenase activity
ISU00_RS07470	COG0516	GMP reductase activity
ISU00_RS07520	COG1294	oxidase, subunit
ISU00_RS07525	COG1271	oxidase subunit
ISU00_RS07540	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ISU00_RS07545	COG1335	isochorismatase
ISU00_RS07550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ISU00_RS07625	COG2345	Transcriptional regulator
ISU00_RS07640	COG2382	esterase
ISU00_RS07645	COG1022	Amp-dependent synthetase and ligase
ISU00_RS07675	COG3384	dioxygenase
ISU00_RS07680	COG0702	epimerase
ISU00_RS07705	COG2819	hydrolase of the alpha beta superfamily
ISU00_RS07730	COG0823	Involved in the tonB-independent uptake of proteins
ISU00_RS07730	COG1506	peptidase
ISU00_RS07795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISU00_RS07825	COG2267	carboxylic ester hydrolase activity
ISU00_RS07885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISU00_RS07985	COG0154	amidase activity
ISU00_RS08015	COG0629	single-stranded DNA binding
ISU00_RS08085	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ISU00_RS08095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISU00_RS08095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISU00_RS08100	COG1619	proteins homologs of microcin C7 resistance protein MccF
ISU00_RS08105	COG0823	Involved in the tonB-independent uptake of proteins
ISU00_RS08105	COG1506	peptidase
ISU00_RS08110	COG0792	nuclease activity
ISU00_RS08120	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ISU00_RS08125	COG0194	GDP metabolic process
ISU00_RS08140	COG0697	spore germination
ISU00_RS08165	COG0626	cystathionine gamma-synthase activity
ISU00_RS08175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ISU00_RS08185	COG1381	Involved in DNA repair and RecF pathway recombination
ISU00_RS08200	COG2137	regulation of response to DNA damage stimulus
ISU00_RS08215	COG0298	carbon dioxide binding
ISU00_RS08220	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ISU00_RS08225	COG0375	protein maturation
ISU00_RS08235	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ISU00_RS08245	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ISU00_RS08250	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ISU00_RS08260	COG0309	Hydrogenase expression formation protein (HypE)
ISU00_RS08270	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISU00_RS08275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISU00_RS08285	COG1629	transport
ISU00_RS08290	COG0363	glucosamine-6-phosphate deaminase activity
ISU00_RS08295	COG3275	phosphorelay sensor kinase activity
ISU00_RS08300	COG3279	Response regulator of the LytR AlgR family
ISU00_RS08305	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISU00_RS08335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISU00_RS08345	COG0297	glycogen (starch) synthase activity
ISU00_RS08350	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ISU00_RS08355	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ISU00_RS08375	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ISU00_RS08380	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ISU00_RS08390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ISU00_RS08395	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISU00_RS08405	COG0189	ligase activity
ISU00_RS08410	COG0189	ligase activity
ISU00_RS08410	COG4067	protein conserved in archaea
ISU00_RS08415	COG0322	excinuclease ABC activity
ISU00_RS08420	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISU00_RS08425	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ISU00_RS08430	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ISU00_RS08450	COG0166	Belongs to the GPI family
ISU00_RS08455	COG4771	TonB-dependent receptor
ISU00_RS08470	COG0629	single-stranded DNA binding
ISU00_RS08480	COG0776	regulation of translation
ISU00_RS08495	COG0667	Aldo Keto reductase
ISU00_RS08505	COG0708	Exodeoxyribonuclease III
ISU00_RS08520	COG0423	glycine-tRNA ligase activity
ISU00_RS08530	COG1040	competence protein
ISU00_RS08545	COG0436	Aminotransferase
ISU00_RS08565	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ISU00_RS08575	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ISU00_RS08600	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ISU00_RS08615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISU00_RS08625	COG3852	Histidine kinase
ISU00_RS08630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISU00_RS08640	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ISU00_RS08650	COG0519	Catalyzes the synthesis of GMP from XMP
ISU00_RS08660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ISU00_RS08665	COG1968	undecaprenyl-diphosphatase activity
ISU00_RS08675	COG2177	Part of the ABC transporter FtsEX involved in
ISU00_RS08685	COG0495	leucyl-tRNA aminoacylation
ISU00_RS08695	COG0686	Belongs to the AlaDH PNT family
ISU00_RS08705	COG1522	sequence-specific DNA binding
ISU00_RS08715	COG2363	Small membrane protein
ISU00_RS08720	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ISU00_RS08735	COG0463	Glycosyl transferase, family 2
ISU00_RS08740	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISU00_RS08750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ISU00_RS08755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ISU00_RS08770	COG0745	RESPONSE REGULATOR receiver
ISU00_RS08775	COG5002	protein histidine kinase activity
ISU00_RS08780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ISU00_RS08785	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ISU00_RS08800	COG0489	protein tyrosine kinase activity
ISU00_RS08810	COG0492	ferredoxin-NADP+ reductase activity
ISU00_RS08820	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ISU00_RS08820	COG1013	pyruvate-flavodoxin oxidoreductase activity
ISU00_RS08820	COG0674	pyruvate-flavodoxin oxidoreductase activity
ISU00_RS08820	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ISU00_RS08825	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU00_RS08830	COG0674	pyruvate-flavodoxin oxidoreductase activity
ISU00_RS08830	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ISU00_RS08835	COG1013	pyruvate-flavodoxin oxidoreductase activity
ISU00_RS08840	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU00_RS08845	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU00_RS08850	COG0649	NAD binding
ISU00_RS08855	COG0649	NAD binding
ISU00_RS08855	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU00_RS08860	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ISU00_RS08875	COG0713	ATP synthesis coupled electron transport
ISU00_RS08880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISU00_RS08885	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU00_RS08900	COG0633	Ferredoxin
ISU00_RS08925	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ISU00_RS08930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ISU00_RS08935	COG0228	four-way junction DNA binding
ISU00_RS08940	COG2706	6-phosphogluconolactonase activity
ISU00_RS08955	COG3118	belongs to the thioredoxin family
ISU00_RS08960	COG0740	serine-type endopeptidase activity
ISU00_RS09075	COG1216	Glycosyl transferase, family 2
ISU00_RS09080	COG1216	Glycosyl transferase, family 2
ISU00_RS09085	COG1215	transferase activity, transferring glycosyl groups
ISU00_RS09095	COG0463	Glycosyl transferase, family 2
ISU00_RS09100	COG0463	Glycosyl transferase, family 2
ISU00_RS09105	COG0110	maltose O-acetyltransferase activity
ISU00_RS09115	COG0463	Glycosyl transferase, family 2
ISU00_RS09165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISU00_RS09175	COG0489	protein tyrosine kinase activity
ISU00_RS09175	COG3206	protein involved in exopolysaccharide biosynthesis
ISU00_RS09185	COG4585	Histidine kinase
ISU00_RS09235	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ISU00_RS09240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISU00_RS09315	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ISU00_RS09345	COG3119	arylsulfatase activity
ISU00_RS09350	COG3119	arylsulfatase activity
ISU00_RS09360	COG3119	arylsulfatase activity
ISU00_RS09375	COG1538	Outer membrane efflux protein
ISU00_RS09380	COG1136	(ABC) transporter
ISU00_RS09385	COG0577	efflux transmembrane transporter activity
ISU00_RS09395	COG0577	efflux transmembrane transporter activity
ISU00_RS09405	COG0577	efflux transmembrane transporter activity
ISU00_RS09405	COG1136	(ABC) transporter
ISU00_RS09410	COG0577	efflux transmembrane transporter activity
ISU00_RS09415	COG0577	efflux transmembrane transporter activity
ISU00_RS09420	COG1136	(ABC) transporter
ISU00_RS09435	COG3852	Histidine kinase
ISU00_RS09440	COG1621	beta-fructofuranosidase activity
ISU00_RS09445	COG2814	Major facilitator Superfamily
ISU00_RS09455	COG3250	beta-galactosidase activity
ISU00_RS09460	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ISU00_RS09470	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ISU00_RS09475	COG1085	galactose-1-phosphate uridylyltransferase
ISU00_RS09505	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ISU00_RS09510	COG4206	TonB-dependent receptor
ISU00_RS09510	COG1629	transport
ISU00_RS09525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU00_RS09530	COG1554	hydrolase, family 65, central catalytic
ISU00_RS09535	COG0366	Alpha amylase catalytic
ISU00_RS09540	COG0366	Alpha amylase catalytic
ISU00_RS09545	COG0366	Alpha amylase catalytic
ISU00_RS09565	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ISU00_RS09570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ISU00_RS09575	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ISU00_RS09590	COG1252	NADH dehydrogenase
ISU00_RS09630	COG5658	integral membrane protein
ISU00_RS09635	COG0640	Transcriptional regulator
ISU00_RS09675	COG2031	fatty acid transporter
ISU00_RS09690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU00_RS09695	COG4771	TonB-dependent receptor
ISU00_RS09700	COG2267	carboxylic ester hydrolase activity
ISU00_RS09710	COG1028	Short-chain dehydrogenase reductase Sdr
ISU00_RS09725	COG2819	hydrolase of the alpha beta superfamily
ISU00_RS09765	COG3383	formate dehydrogenase (NAD+) activity
ISU00_RS09770	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ISU00_RS09775	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ISU00_RS09780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ISU00_RS09835	COG3279	Response regulator of the LytR AlgR family
ISU00_RS09840	COG2972	Histidine kinase
ISU00_RS09925	COG1946	Acyl-CoA thioesterase
ISU00_RS09930	COG2081	HI0933 family
ISU00_RS09955	COG1187	pseudouridine synthase activity
ISU00_RS09965	COG1166	arginine decarboxylase activity
ISU00_RS09970	COG0010	Belongs to the arginase family
ISU00_RS09995	COG1215	transferase activity, transferring glycosyl groups
ISU00_RS10010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISU00_RS10030	COG2226	methyltransferase
ISU00_RS10035	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ISU00_RS10055	COG1331	Highly conserved protein containing a thioredoxin domain
ISU00_RS10070	COG0656	L-ascorbic acid biosynthetic process
ISU00_RS10100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISU00_RS10110	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ISU00_RS10135	COG1253	flavin adenine dinucleotide binding
ISU00_RS10155	COG3104	oligopeptide transport
ISU00_RS10165	COG4232	protein-disulfide reductase activity
ISU00_RS10170	COG0658	competence protein
ISU00_RS10170	COG2333	competence protein COMEC
ISU00_RS10175	COG0791	NLP P60 protein
ISU00_RS10180	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISU00_RS10190	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ISU00_RS10200	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ISU00_RS10205	COG0596	Alpha beta hydrolase
ISU00_RS10210	COG2001	Belongs to the MraZ family
ISU00_RS10215	COG0275	rRNA processing
ISU00_RS10225	COG0768	penicillin binding
ISU00_RS10230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ISU00_RS10235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISU00_RS10240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ISU00_RS10245	COG0772	Belongs to the SEDS family
ISU00_RS10250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ISU00_RS10255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISU00_RS10270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISU00_RS10275	COG1610	YqeY-like protein
ISU00_RS10290	COG1028	Short-chain dehydrogenase reductase Sdr
ISU00_RS10310	COG0516	GMP reductase activity
ISU00_RS10310	COG0517	IMP dehydrogenase activity
ISU00_RS10315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISU00_RS10320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISU00_RS10330	COG3292	Two component regulator propeller
ISU00_RS10330	COG0745	RESPONSE REGULATOR receiver
ISU00_RS10330	COG2205	protein histidine kinase activity
ISU00_RS10365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISU00_RS10375	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU00_RS10385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ISU00_RS10390	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ISU00_RS10395	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISU00_RS10405	COG1185	polyribonucleotide nucleotidyltransferase activity
ISU00_RS10410	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ISU00_RS10420	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ISU00_RS10425	COG0191	fructose-bisphosphate aldolase activity
ISU00_RS10455	COG2226	methyltransferase
ISU00_RS10460	COG0569	domain protein
ISU00_RS10465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ISU00_RS10475	COG0436	Aminotransferase
ISU00_RS10480	COG3239	Fatty acid desaturase
ISU00_RS10485	COG0357	Ribosomal RNA small subunit methyltransferase G
ISU00_RS10500	COG1012	belongs to the aldehyde dehydrogenase family
ISU00_RS10510	COG0076	glutamate decarboxylase activity
ISU00_RS10525	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISU00_RS10530	COG1805	sodium ion transport
ISU00_RS10535	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISU00_RS10540	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISU00_RS10545	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISU00_RS10560	COG1477	protein flavinylation
ISU00_RS10580	COG0427	acetyl-CoA hydrolase
ISU00_RS10590	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ISU00_RS10595	COG0501	Belongs to the peptidase M48B family
ISU00_RS10610	COG3340	Belongs to the peptidase S51 family
ISU00_RS10635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISU00_RS10650	COG0662	Cupin 2, conserved barrel domain protein
ISU00_RS10655	COG1028	Short-chain dehydrogenase reductase Sdr
ISU00_RS10670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU00_RS10675	COG3844	kynureninase activity
ISU00_RS10700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ISU00_RS10705	COG1663	tetraacyldisaccharide 4'-kinase activity
ISU00_RS10720	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ISU00_RS10750	COG1595	DNA-templated transcription, initiation
ISU00_RS10755	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISU00_RS10760	COG0436	Aminotransferase
ISU00_RS10765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU00_RS10775	COG0525	valine-tRNA ligase activity
ISU00_RS10780	COG0772	Belongs to the SEDS family
ISU00_RS10785	COG0768	penicillin binding
ISU00_RS10800	COG1077	Cell shape determining protein MreB Mrl
ISU00_RS10805	COG0138	bifunctional purine biosynthesis protein purh
ISU00_RS10810	COG1136	(ABC) transporter
ISU00_RS10810	COG0577	efflux transmembrane transporter activity
ISU00_RS10830	COG0459	protein refolding
ISU00_RS10835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ISU00_RS10860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ISU00_RS10885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ISU00_RS10905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISU00_RS10915	COG0488	(ABC) transporter
ISU00_RS10960	COG0612	Peptidase, M16
ISU00_RS10970	COG3275	phosphorelay sensor kinase activity
ISU00_RS10975	COG3279	Response regulator of the LytR AlgR family
ISU00_RS10990	COG3275	phosphorelay sensor kinase activity
ISU00_RS11045	COG1388	LysM domain
ISU00_RS11045	COG0791	NLP P60 protein
ISU00_RS11055	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ISU00_RS11090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU00_RS11090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISU00_RS11105	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ISU00_RS11120	COG1160	GTP binding
ISU00_RS11130	COG1476	TRANSCRIPTIONal
ISU00_RS11150	COG1704	LemA family
ISU00_RS11160	COG0739	heme binding
ISU00_RS11165	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ISU00_RS11175	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ISU00_RS11180	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISU00_RS11190	COG0564	pseudouridine synthase activity
ISU00_RS11200	COG3022	response to hydroperoxide
ISU00_RS11225	COG0159	tryptophan synthase activity
ISU00_RS11240	COG0133	tryptophan synthase activity
ISU00_RS11245	COG0135	phosphoribosylanthranilate isomerase activity
ISU00_RS11250	COG0134	indole-3-glycerol-phosphate synthase activity
ISU00_RS11255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISU00_RS11265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISU00_RS11270	COG1846	Transcriptional regulator
ISU00_RS11275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISU00_RS11285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISU00_RS11295	COG4232	protein-disulfide reductase activity
ISU00_RS11305	COG4771	TonB-dependent receptor
ISU00_RS11310	COG0702	epimerase
ISU00_RS11320	COG3534	alpha-L-arabinofuranosidase
ISU00_RS11325	COG3507	Belongs to the glycosyl hydrolase 43 family
ISU00_RS11330	COG3507	Belongs to the glycosyl hydrolase 43 family
ISU00_RS11335	COG3507	Belongs to the glycosyl hydrolase 43 family
ISU00_RS11340	COG2211	Major facilitator Superfamily
ISU00_RS11345	COG3940	Belongs to the glycosyl hydrolase 43 family
ISU00_RS11365	COG2160	L-arabinose isomerase activity
ISU00_RS11380	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISU00_RS11385	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ISU00_RS11400	COG3292	Two component regulator propeller
ISU00_RS11400	COG2205	protein histidine kinase activity
ISU00_RS11400	COG0745	RESPONSE REGULATOR receiver
ISU00_RS11405	COG1629	transport
ISU00_RS11455	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ISU00_RS11460	COG3586	endonuclease activity
ISU00_RS11530	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ISU00_RS11535	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ISU00_RS11540	COG0215	cysteine-tRNA ligase activity
ISU00_RS11545	COG0302	gtp cyclohydrolase
ISU00_RS11565	COG0442	prolyl-tRNA aminoacylation
ISU00_RS11575	COG0268	Binds directly to 16S ribosomal RNA
ISU00_RS11595	COG0101	tRNA pseudouridine synthase activity
ISU00_RS11600	COG1132	(ABC) transporter
ISU00_RS11610	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ISU00_RS11615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISU00_RS11630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISU00_RS11635	COG0149	triose-phosphate isomerase activity
ISU00_RS11640	COG2264	protein methyltransferase activity
ISU00_RS11660	COG0471	metal ion transport
ISU00_RS11660	COG0490	domain, Protein
ISU00_RS11665	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ISU00_RS11695	COG3118	belongs to the thioredoxin family
ISU00_RS11700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISU00_RS11715	COG0243	molybdopterin cofactor binding
ISU00_RS11770	COG0174	glutamine synthetase
ISU00_RS11790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ISU00_RS11795	COG0284	orotidine-5'-phosphate decarboxylase activity
ISU00_RS11825	COG0788	formyltetrahydrofolate deformylase activity
ISU00_RS11830	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISU00_RS11830	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISU00_RS11830	COG1703	isobutyryl-CoA mutase activity
ISU00_RS11855	COG1522	sequence-specific DNA binding
ISU00_RS11870	COG0492	ferredoxin-NADP+ reductase activity
ISU00_RS11875	COG2814	Major facilitator Superfamily
ISU00_RS11885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ISU00_RS11905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISU00_RS11915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISU00_RS11915	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ISU00_RS11920	COG1090	epimerase
ISU00_RS11930	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ISU00_RS11935	COG0484	heat shock protein binding
ISU00_RS11940	COG4152	abc transporter atp-binding protein
ISU00_RS11945	COG1668	transmembrane transport
ISU00_RS11950	COG3264	Mechanosensitive ion channel
ISU00_RS11950	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ISU00_RS11970	COG2326	polyphosphate kinase activity
ISU00_RS12005	COG0793	Belongs to the peptidase S41A family
ISU00_RS12005	COG4946	Tricorn protease homolog
ISU00_RS12060	COG0823	Involved in the tonB-independent uptake of proteins
ISU00_RS12060	COG1506	peptidase
ISU00_RS12080	COG4191	Histidine kinase
ISU00_RS12085	COG0784	Response regulator, receiver
ISU00_RS12085	COG4191	Histidine kinase
ISU00_RS12095	COG0784	Response regulator, receiver
ISU00_RS12095	COG4191	Histidine kinase
ISU00_RS12100	COG4191	Histidine kinase
ISU00_RS12360	COG0745	RESPONSE REGULATOR receiver
ISU00_RS12365	COG0784	Response regulator, receiver
ISU00_RS12365	COG2198	Histidine kinase
ISU00_RS12365	COG5002	protein histidine kinase activity
ISU00_RS12385	COG2311	Membrane
ISU00_RS12410	COG0019	diaminopimelate decarboxylase activity
ISU00_RS12415	COG0045	succinate-CoA ligase (ADP-forming) activity
ISU00_RS12435	COG3693	PFAM glycoside hydrolase, family 10
ISU00_RS12435	COG2382	esterase
ISU00_RS12435	COG3507	Belongs to the glycosyl hydrolase 43 family
ISU00_RS12445	COG0556	nucleotide-excision repair
ISU00_RS12460	COG1131	(ABC) transporter
ISU00_RS12475	COG1612	heme a metabolic process
ISU00_RS12480	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ISU00_RS12480	COG0617	tRNA 3'-terminal CCA addition
ISU00_RS12480	COG0517	IMP dehydrogenase activity
ISU00_RS12485	COG0009	L-threonylcarbamoyladenylate synthase
ISU00_RS12515	COG2171	N-acyltransferase activity
ISU00_RS12520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ISU00_RS12525	COG0242	peptide deformylase activity
ISU00_RS12535	COG3956	TIGRFAM MazG family protein
ISU00_RS12545	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISU00_RS12565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISU00_RS12575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ISU00_RS12600	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ISU00_RS12605	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISU00_RS12605	COG0519	Catalyzes the synthesis of GMP from XMP
ISU00_RS12620	COG0504	CTP synthase activity
ISU00_RS12625	COG0706	membrane insertase activity
ISU00_RS12630	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ISU00_RS12640	COG0482	sulfurtransferase activity
ISU00_RS12645	COG1404	Belongs to the peptidase S8 family
ISU00_RS12655	COG0534	Mate efflux family protein
ISU00_RS12665	COG0671	phosphoesterase, PA-phosphatase related
ISU00_RS12680	COG0463	Glycosyl transferase, family 2
ISU00_RS12690	COG1703	isobutyryl-CoA mutase activity
ISU00_RS12700	COG1595	DNA-templated transcription, initiation
ISU00_RS12725	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ISU00_RS12730	COG3265	gluconokinase activity
ISU00_RS12735	COG3386	PFAM SMP-30 Gluconolaconase
ISU00_RS12745	COG0653	protein targeting
ISU00_RS12760	COG1136	(ABC) transporter
ISU00_RS12770	COG0488	(ABC) transporter
ISU00_RS12780	COG0489	protein tyrosine kinase activity
ISU00_RS12785	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISU00_RS12795	COG2264	protein methyltransferase activity
ISU00_RS12830	COG0463	Glycosyl transferase, family 2
ISU00_RS12835	COG0438	transferase activity, transferring glycosyl groups
ISU00_RS12845	COG0463	Glycosyl transferase, family 2
ISU00_RS12880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISU00_RS12900	COG2226	methyltransferase
ISU00_RS12920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISU00_RS12925	COG0438	transferase activity, transferring glycosyl groups
ISU00_RS12975	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ISU00_RS12980	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ISU00_RS12995	COG2354	Protein conserved in bacteria
ISU00_RS13000	COG1137	ATPase activity
ISU00_RS13005	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU00_RS13010	COG0805	protein transport
ISU00_RS13015	COG0517	IMP dehydrogenase activity
ISU00_RS13015	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ISU00_RS13020	COG0514	ATP-dependent DNA helicase (RecQ)
ISU00_RS13025	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISU00_RS13045	COG2972	Histidine kinase
ISU00_RS13100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ISU00_RS13105	COG0297	glycogen (starch) synthase activity
ISU00_RS13110	COG2234	aminopeptidase activity
ISU00_RS13115	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ISU00_RS13120	COG3387	PFAM Glycoside hydrolase 15-related
ISU00_RS13135	COG1960	acyl-CoA dehydrogenase activity
ISU00_RS13140	COG0183	Belongs to the thiolase family
ISU00_RS13145	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISU00_RS13145	COG1024	Enoyl-CoA hydratase
ISU00_RS13150	COG1846	Transcriptional regulator
ISU00_RS13155	COG1022	Amp-dependent synthetase and ligase
ISU00_RS13160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISU00_RS13160	COG0047	phosphoribosylformylglycinamidine synthase activity
ISU00_RS13165	COG3001	Fructosamine kinase
ISU00_RS13170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISU00_RS13170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ISU00_RS13190	COG1595	DNA-templated transcription, initiation
ISU00_RS13195	COG1132	(ABC) transporter
ISU00_RS13200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISU00_RS13215	COG0254	rRNA binding
ISU00_RS13225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ISU00_RS13250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISU00_RS13270	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ISU00_RS13275	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISU00_RS13285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISU00_RS13300	COG1322	Protein conserved in bacteria
ISU00_RS13305	COG1120	ATPase activity
ISU00_RS13310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU00_RS13320	COG4206	TonB-dependent receptor
ISU00_RS13375	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ISU00_RS13400	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISU00_RS13410	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ISU00_RS13425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISU00_RS13430	COG3279	Response regulator of the LytR AlgR family
ISU00_RS13435	COG0360	Binds together with S18 to 16S ribosomal RNA
ISU00_RS13440	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ISU00_RS13445	COG0359	binds to the 23S rRNA
ISU00_RS13460	COG0577	efflux transmembrane transporter activity
ISU00_RS13465	COG0124	histidyl-tRNA synthetase
ISU00_RS13490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISU00_RS13515	COG1678	Uncharacterized ACR, COG1678
ISU00_RS13525	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ISU00_RS13530	COG0514	ATP-dependent DNA helicase (RecQ)
ISU00_RS13550	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ISU00_RS13565	COG1473	amidohydrolase
ISU00_RS13570	COG0415	Belongs to the DNA photolyase family
ISU00_RS13585	COG0386	Belongs to the glutathione peroxidase family
ISU00_RS13590	COG1028	Short-chain dehydrogenase reductase Sdr
ISU00_RS13605	COG3046	protein related to deoxyribodipyrimidine photolyase
ISU00_RS13610	COG0702	epimerase
ISU00_RS13635	COG1696	Membrane protein involved in D-alanine export
ISU00_RS13685	COG0424	maF-like protein
ISU00_RS13705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU00_RS13705	COG1333	cytochrome c biogenesis protein
ISU00_RS13710	COG1970	mechanosensitive ion channel activity
ISU00_RS13725	COG0626	cystathionine gamma-synthase activity
ISU00_RS13730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ISU00_RS13740	COG2234	aminopeptidase activity
ISU00_RS13765	COG0484	heat shock protein binding
ISU00_RS13770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU00_RS13785	COG2217	Heavy metal translocating P-type atpase
ISU00_RS13800	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU00_RS13830	COG2003	Belongs to the UPF0758 family
ISU00_RS13875	COG4974	Belongs to the 'phage' integrase family
ISU00_RS13880	COG1760	l-serine dehydratase
ISU00_RS13885	COG0667	Aldo Keto reductase
ISU00_RS13890	COG0673	inositol 2-dehydrogenase activity
ISU00_RS13900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISU00_RS13915	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISU00_RS13915	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISU00_RS13930	COG1674	ftsk spoiiie
ISU00_RS13940	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ISU00_RS13950	COG0072	phenylalanine-tRNA ligase activity
ISU00_RS13950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISU00_RS13970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISU00_RS13985	COG0069	glutamate synthase activity
ISU00_RS13990	COG1473	amidohydrolase
ISU00_RS14010	COG0009	L-threonylcarbamoyladenylate synthase
ISU00_RS14035	COG0693	protein deglycase activity
ISU00_RS14065	COG0022	dehydrogenase e1 component
ISU00_RS14075	COG1611	Belongs to the LOG family
ISU00_RS14085	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISU00_RS14100	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ISU00_RS14125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISU00_RS14140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ISU00_RS14145	COG0823	Involved in the tonB-independent uptake of proteins
ISU00_RS14150	COG1629	transport
ISU00_RS14150	COG4206	TonB-dependent receptor
ISU00_RS14165	COG5337	Spore coat protein CotH
ISU00_RS14170	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISU00_RS14180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISU00_RS14205	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ISU00_RS14215	COG4771	TonB-dependent receptor
ISU00_RS14220	COG0702	epimerase
ISU00_RS14245	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU00_RS14255	COG3119	arylsulfatase activity
ISU00_RS14270	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISU00_RS14295	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ISU00_RS14295	COG1013	pyruvate-flavodoxin oxidoreductase activity
ISU00_RS14295	COG0674	pyruvate-flavodoxin oxidoreductase activity
ISU00_RS14295	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ISU00_RS14305	COG3604	Transcriptional regulator
ISU00_RS14320	COG0592	DNA-directed DNA polymerase activity
ISU00_RS14340	COG1702	phosphate starvation-inducible protein PhoH
ISU00_RS14345	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ISU00_RS14350	COG2808	Putative FMN-binding domain
ISU00_RS14355	COG2318	DinB family
ISU00_RS14360	COG1115	amino acid carrier protein
ISU00_RS14370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISU00_RS14375	COG2207	Transcriptional regulator
ISU00_RS14380	COG1012	belongs to the aldehyde dehydrogenase family
ISU00_RS14390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ISU00_RS14415	COG3258	Cytochrome c
ISU00_RS14430	COG2610	gluconate transmembrane transporter activity
ISU00_RS14435	COG0129	dihydroxy-acid dehydratase activity
ISU00_RS14445	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ISU00_RS14450	COG0857	belongs to the CobB CobQ family
ISU00_RS14450	COG0280	phosphate acetyltransferase
ISU00_RS14455	COG0217	transcriptional regulatory protein
ISU00_RS14460	COG2154	pterin-4-alpha-carbinolamine dehydratase
ISU00_RS14470	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ISU00_RS14475	COG0006	proline dipeptidase activity
ISU00_RS14480	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ISU00_RS14485	COG0083	homoserine kinase activity
ISU00_RS14495	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISU00_RS14500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISU00_RS14510	COG0542	response to heat
ISU00_RS14530	COG0183	Belongs to the thiolase family
ISU00_RS14575	COG3279	Response regulator of the LytR AlgR family
ISU00_RS14640	COG5520	Belongs to the glycosyl hydrolase 30 family
ISU00_RS14650	COG2192	nodulation
ISU00_RS14670	COG0702	epimerase
ISU00_RS14675	COG4771	TonB-dependent receptor
ISU00_RS14685	COG2211	Major facilitator Superfamily
ISU00_RS14695	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU00_RS14705	COG1609	Transcriptional regulator
ISU00_RS14720	COG1482	cell wall glycoprotein biosynthetic process
ISU00_RS14725	COG5002	protein histidine kinase activity
ISU00_RS14730	COG0745	RESPONSE REGULATOR receiver
ISU00_RS14740	COG0076	glutamate decarboxylase activity
ISU00_RS14745	COG0450	alkyl hydroperoxide reductase
ISU00_RS14760	COG1252	NADH dehydrogenase
ISU00_RS14815	COG0515	serine threonine protein kinase
ISU00_RS14815	COG2815	serine threonine protein kinase
ISU00_RS14910	COG2176	DNA-directed DNA polymerase activity
ISU00_RS14925	COG0628	permease
ISU00_RS14935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU00_RS14945	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISU00_RS14955	COG0251	oxidation-reduction process
ISU00_RS14965	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISU00_RS14975	COG0247	lactate metabolic process
ISU00_RS14975	COG2181	nitrate reductase activity
ISU00_RS14990	COG0247	lactate metabolic process
ISU00_RS14990	COG2181	nitrate reductase activity
ISU00_RS15000	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU00_RS15005	COG0438	transferase activity, transferring glycosyl groups
ISU00_RS15015	COG0247	lactate metabolic process
ISU00_RS15015	COG0277	FAD linked oxidase domain protein
ISU00_RS15020	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISU00_RS15025	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ISU00_RS15030	COG1301	dicarboxylic acid transport
ISU00_RS15035	COG0189	ligase activity
ISU00_RS15050	COG0189	ligase activity
ISU00_RS15055	COG3011	Protein conserved in bacteria
ISU00_RS15060	COG1193	negative regulation of DNA recombination
ISU00_RS15065	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ISU00_RS15075	COG0813	purine-nucleoside phosphorylase activity
ISU00_RS15095	COG0022	dehydrogenase e1 component
ISU00_RS15130	COG2130	NADP-dependent
ISU00_RS15165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISU00_RS15275	COG4974	Belongs to the 'phage' integrase family
ISU00_RS15370	COG3250	beta-galactosidase activity
ISU00_RS15380	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ISU00_RS15400	COG1278	Cold shock
ISU00_RS15410	COG2353	YceI-like domain
ISU00_RS15420	COG0668	transmembrane transport
ISU00_RS15435	COG2824	Alkylphosphonate utilization operon protein PhnA
ISU00_RS15465	COG0778	Nitroreductase
ISU00_RS15470	COG0612	Peptidase, M16
ISU00_RS15475	COG1764	response to oxidative stress
ISU00_RS15490	COG2957	Belongs to the agmatine deiminase family
ISU00_RS15495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISU00_RS15495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU00_RS15500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISU00_RS15500	COG0574	Belongs to the PEP-utilizing enzyme family
ISU00_RS15535	COG0628	permease
ISU00_RS15545	COG2814	Major facilitator Superfamily
ISU00_RS15550	COG0668	transmembrane transport
ISU00_RS15555	COG2885	chlorophyll binding
ISU00_RS15565	COG1607	acyl-coa hydrolase
ISU00_RS15585	COG0668	transmembrane transport
ISU00_RS15590	COG0598	Magnesium transport protein CorA
ISU00_RS15605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISU00_RS15610	COG0205	6-phosphofructokinase activity
ISU00_RS15620	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ISU00_RS15630	COG0140	phosphoribosyl-ATP diphosphatase activity
ISU00_RS15630	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISU00_RS15635	COG0107	imidazoleglycerol-phosphate synthase activity
ISU00_RS15640	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ISU00_RS15650	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISU00_RS15650	COG0131	Imidazoleglycerol-phosphate dehydratase
ISU00_RS15655	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISU00_RS15660	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISU00_RS15665	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ISU00_RS15680	COG1028	Short-chain dehydrogenase reductase Sdr
ISU00_RS15685	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ISU00_RS15695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ISU00_RS15700	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISU00_RS15705	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ISU00_RS15705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISU00_RS15710	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISU00_RS15715	COG1078	dGTPase activity
ISU00_RS15735	COG0686	Belongs to the AlaDH PNT family
ISU00_RS15745	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ISU00_RS15750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISU00_RS15765	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ISU00_RS15770	COG1522	sequence-specific DNA binding
ISU00_RS15810	COG0366	Alpha amylase catalytic
ISU00_RS15820	COG1104	cysteine desulfurase activity
ISU00_RS15845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISU00_RS15850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ISU00_RS15875	COG0116	Belongs to the methyltransferase superfamily
ISU00_RS15890	COG1272	protein, Hemolysin III
ISU00_RS15900	COG1363	Peptidase, m42
ISU00_RS15905	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ISU00_RS15910	COG2339	peptidase activity
ISU00_RS15925	COG0511	ligase activity, forming carbon-carbon bonds
ISU00_RS15930	COG0439	Biotin carboxylase
ISU00_RS15935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ISU00_RS15955	COG4771	TonB-dependent receptor
ISU00_RS15980	COG2814	Major facilitator Superfamily
ISU00_RS15990	COG0667	Aldo Keto reductase
ISU00_RS16000	COG2217	Heavy metal translocating P-type atpase
ISU00_RS16005	COG0012	GTP binding
ISU00_RS16010	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISU00_RS16020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU00_RS16030	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ISU00_RS16035	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISU00_RS16055	COG4771	TonB-dependent receptor
ISU00_RS16070	COG2986	histidine ammonia-lyase
ISU00_RS16075	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ISU00_RS16085	COG0302	gtp cyclohydrolase
ISU00_RS16090	COG1136	(ABC) transporter
ISU00_RS16110	COG1216	Glycosyl transferase, family 2
ISU00_RS16120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISU00_RS16155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISU00_RS16160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISU00_RS16170	COG1595	DNA-templated transcription, initiation
ISU00_RS16175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISU00_RS16235	COG0156	8-amino-7-oxononanoate synthase activity
ISU00_RS16250	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ISU00_RS16270	COG2308	Evidence 4 Homologs of previously reported genes of
ISU00_RS16295	COG1393	Belongs to the ArsC family
ISU00_RS16325	COG2169	Transcriptional regulator
ISU00_RS16340	COG0405	Gamma-glutamyltransferase
ISU00_RS16400	COG1288	antiporter activity
ISU00_RS16425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU00_RS16470	COG3458	cephalosporin-C deacetylase activity
ISU00_RS16510	COG2205	protein histidine kinase activity
ISU00_RS16510	COG3292	Two component regulator propeller
ISU00_RS16510	COG0745	RESPONSE REGULATOR receiver
ISU00_RS16530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISU00_RS16540	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ISU00_RS16570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISU00_RS16575	COG3655	Transcriptional regulator
ISU00_RS16630	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ISU00_RS16635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISU00_RS16650	COG1047	Peptidyl-prolyl cis-trans
ISU00_RS16665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ISU00_RS16675	COG1309	transcriptional regulator
ISU00_RS16695	COG0450	alkyl hydroperoxide reductase
ISU00_RS16710	COG1228	amidohydrolase
ISU00_RS16745	COG0494	nUDIX hydrolase
ISU00_RS16765	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISU00_RS16780	COG0488	(ABC) transporter
ISU00_RS16790	COG1741	Belongs to the pirin family
ISU00_RS16795	COG1846	Transcriptional regulator
ISU00_RS16805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ISU00_RS16825	COG1266	CAAX protease self-immunity
ISU00_RS16840	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISU00_RS16845	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISU00_RS16850	COG1575	Belongs to the MenA family. Type 1 subfamily
ISU00_RS16865	COG2996	Protein conserved in bacteria
ISU00_RS16875	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ISU00_RS16910	COG1454	alcohol dehydrogenase
ISU00_RS16920	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ISU00_RS16930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISU00_RS16945	COG0742	ribosomal rna small subunit methyltransferase
ISU00_RS16960	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ISU00_RS16985	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISU00_RS17010	COG2885	chlorophyll binding
ISU00_RS17020	COG0259	pyridoxamine-phosphate oxidase activity
ISU00_RS17025	COG1234	tRNA 3'-trailer cleavage
ISU00_RS17035	COG0540	Belongs to the ATCase OTCase family
ISU00_RS17040	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ISU00_RS17050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ISU00_RS17060	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ISU00_RS17065	COG1595	DNA-templated transcription, initiation
ISU00_RS17100	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ISU00_RS17110	COG0366	Alpha amylase catalytic
ISU00_RS17115	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ISU00_RS17125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU00_RS17155	COG4974	Belongs to the 'phage' integrase family
ISU00_RS17160	COG1418	mRNA catabolic process
ISU00_RS17180	COG0739	heme binding
ISU00_RS17190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISU00_RS17210	COG0107	imidazoleglycerol-phosphate synthase activity
ISU00_RS17225	COG0443	Heat shock 70 kDa protein
ISU00_RS17230	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ISU00_RS17240	COG0564	pseudouridine synthase activity
ISU00_RS17250	COG4585	Histidine kinase
ISU00_RS17265	COG1984	allophanate hydrolase subunit 2
ISU00_RS17270	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ISU00_RS17275	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ISU00_RS17280	COG1914	H( )-stimulated, divalent metal cation uptake system
ISU00_RS17290	COG0606	chelatase, subunit chli
ISU00_RS17295	COG0471	metal ion transport
ISU00_RS17305	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ISU00_RS17310	COG0037	tRNA processing
ISU00_RS17315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISU00_RS17325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU00_RS17335	COG1522	sequence-specific DNA binding
ISU00_RS17340	COG0626	cystathionine gamma-synthase activity
ISU00_RS17345	COG1757	Na H antiporter
ISU00_RS17360	COG0488	(ABC) transporter
ISU00_RS17370	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISU00_RS17375	COG0300	oxidoreductase activity
ISU00_RS17410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ISU00_RS17435	COG0542	response to heat
ISU00_RS17455	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ISU00_RS17465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ISU00_RS17470	COG0673	inositol 2-dehydrogenase activity
ISU00_RS17475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISU00_RS17480	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISU00_RS17485	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISU00_RS17495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISU00_RS17500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISU00_RS17520	COG0237	dephospho-CoA kinase activity
ISU00_RS17530	COG0463	Glycosyl transferase, family 2
ISU00_RS17530	COG1216	Glycosyl transferase, family 2
ISU00_RS17535	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ISU00_RS17540	COG0497	DNA recombination
ISU00_RS17565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISU00_RS17575	COG0737	Belongs to the 5'-nucleotidase family
ISU00_RS17575	COG1525	nuclease
ISU00_RS17575	COG4085	toxin activity
ISU00_RS17580	COG0737	Belongs to the 5'-nucleotidase family
ISU00_RS17600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU00_RS17610	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ISU00_RS17615	COG1611	Belongs to the LOG family
ISU00_RS17620	COG2890	protein-(glutamine-N5) methyltransferase activity
ISU00_RS17630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISU00_RS17630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISU00_RS17635	COG1011	Hydrolase
ISU00_RS17670	COG1288	antiporter activity