locus-tag	class	description
Pan181_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Pan181_RS00020	COG0187	DNA topoisomerase II activity
Pan181_RS00045	COG4191	Histidine kinase
Pan181_RS00130	COG0165	Argininosuccinate lyase
Pan181_RS00140	COG2204	response regulator
Pan181_RS00150	COG0582	viral genome integration into host DNA
Pan181_RS00165	COG1252	NADH dehydrogenase
Pan181_RS00200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Pan181_RS00205	COG1309	transcriptional regulator
Pan181_RS00315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Pan181_RS00325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Pan181_RS00330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Pan181_RS00335	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Pan181_RS00465	COG3119	arylsulfatase activity
Pan181_RS00470	COG0052	Belongs to the universal ribosomal protein uS2 family
Pan181_RS00475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Pan181_RS00480	COG0528	UMP kinase activity
Pan181_RS00485	COG0233	cytoplasmic translational termination
Pan181_RS00495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Pan181_RS00540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Pan181_RS00580	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Pan181_RS00580	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Pan181_RS00590	COG3119	arylsulfatase activity
Pan181_RS00595	COG4636	protein conserved in cyanobacteria
Pan181_RS00605	COG3258	Cytochrome c
Pan181_RS00615	COG0673	inositol 2-dehydrogenase activity
Pan181_RS00635	COG3250	beta-galactosidase activity
Pan181_RS00645	COG0459	protein refolding
Pan181_RS00650	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Pan181_RS00690	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Pan181_RS00695	COG0666	response to abiotic stimulus
Pan181_RS00725	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Pan181_RS00730	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Pan181_RS00745	COG4864	UPF0365 protein
Pan181_RS00795	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Pan181_RS00800	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Pan181_RS00830	COG0437	4 iron, 4 sulfur cluster binding
Pan181_RS00840	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Pan181_RS00875	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_RS00875	COG3321	synthase
Pan181_RS00875	COG0604	alcohol dehydrogenase
Pan181_RS00880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Pan181_RS00900	COG0126	phosphoglycerate kinase activity
Pan181_RS00920	COG0515	serine threonine protein kinase
Pan181_RS00920	COG2815	serine threonine protein kinase
Pan181_RS00935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Pan181_RS00960	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Pan181_RS00975	COG3361	conserved protein (COG2071)
Pan181_RS00985	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Pan181_RS00990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Pan181_RS00995	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Pan181_RS01005	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Pan181_RS01015	COG0758	DNA mediated transformation
Pan181_RS01025	COG2755	lipolytic protein G-D-S-L family
Pan181_RS01025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Pan181_RS01030	COG1228	amidohydrolase
Pan181_RS01050	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Pan181_RS01060	COG0259	pyridoxamine-phosphate oxidase activity
Pan181_RS01065	COG3119	arylsulfatase activity
Pan181_RS01070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Pan181_RS01085	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_RS01110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan181_RS01160	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Pan181_RS01165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Pan181_RS01170	COG0588	phosphoglycerate mutase activity
Pan181_RS01175	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Pan181_RS01260	COG0406	alpha-ribazole phosphatase activity
Pan181_RS01315	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Pan181_RS01345	COG0069	glutamate synthase activity
Pan181_RS01375	COG4771	TonB-dependent receptor
Pan181_RS01405	COG0529	Catalyzes the synthesis of activated sulfate
Pan181_RS01405	COG2895	sulfate adenylyltransferase (ATP) activity
Pan181_RS01420	COG0175	sulfate reduction
Pan181_RS01440	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Pan181_RS01445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Pan181_RS01505	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Pan181_RS01510	COG1408	metallophosphoesterase
Pan181_RS01520	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Pan181_RS01525	COG0488	(ABC) transporter
Pan181_RS01550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Pan181_RS01595	COG5016	pyruvate
Pan181_RS01595	COG0511	ligase activity, forming carbon-carbon bonds
Pan181_RS01630	COG0745	RESPONSE REGULATOR receiver
Pan181_RS01635	COG2204	response regulator
Pan181_RS01645	COG3437	response regulator, receiver
Pan181_RS01660	COG0745	RESPONSE REGULATOR receiver
Pan181_RS01665	COG2201	protein-glutamate methylesterase activity
Pan181_RS01700	COG2258	MOSC domain
Pan181_RS01705	COG0512	Glutamine amidotransferase of anthranilate synthase
Pan181_RS01710	COG2195	Cleaves the N-terminal amino acid of tripeptides
Pan181_RS01715	COG3119	arylsulfatase activity
Pan181_RS01740	COG2801	Transposase and inactivated derivatives
Pan181_RS01805	COG2719	SpoVR family
Pan181_RS01815	COG2718	Belongs to the UPF0229 family
Pan181_RS01825	COG2766	serine protein kinase
Pan181_RS01845	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Pan181_RS01860	COG0539	negative regulation of cytoplasmic translation
Pan181_RS01865	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
Pan181_RS01895	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Pan181_RS01900	COG0799	negative regulation of ribosome biogenesis
Pan181_RS01905	COG0018	arginyl-trna synthetase
Pan181_RS01925	COG2223	nitrite transmembrane transporter activity
Pan181_RS02005	COG3264	Mechanosensitive ion channel
Pan181_RS02005	COG1511	domain protein
Pan181_RS02010	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Pan181_RS02020	COG1530	ribonuclease E activity
Pan181_RS02035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Pan181_RS02035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Pan181_RS02035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Pan181_RS02055	COG4968	Prepilin-type N-terminal cleavage methylation domain
Pan181_RS02080	COG1216	Glycosyl transferase, family 2
Pan181_RS02090	COG2183	response to ionizing radiation
Pan181_RS02110	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Pan181_RS02115	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Pan181_RS02115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Pan181_RS02120	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Pan181_RS02125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Pan181_RS02130	COG0793	Belongs to the peptidase S41A family
Pan181_RS02135	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Pan181_RS02140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Pan181_RS02145	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Pan181_RS02155	COG3842	ATPase activity
Pan181_RS02185	COG0616	signal peptide processing
Pan181_RS02220	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_RS02295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Pan181_RS02300	COG4172	Belongs to the ABC transporter superfamily
Pan181_RS02305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Pan181_RS02315	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
Pan181_RS02340	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Pan181_RS02465	COG0297	glycogen (starch) synthase activity
Pan181_RS02470	COG1448	Aminotransferase
Pan181_RS02500	COG0848	biopolymer transport protein
Pan181_RS02515	COG0159	tryptophan synthase activity
Pan181_RS02530	COG3779	Protein conserved in bacteria
Pan181_RS02535	COG0133	tryptophan synthase activity
Pan181_RS02540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Pan181_RS02545	COG0784	Response regulator, receiver
Pan181_RS02550	COG4251	negative regulation of phosphorylation
Pan181_RS02575	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Pan181_RS02660	COG2304	oxidoreductase activity
Pan181_RS02695	COG1595	DNA-templated transcription, initiation
Pan181_RS02710	COG3707	response regulator
Pan181_RS02715	COG3237	CsbD-like
Pan181_RS02725	COG5487	UPF0391 membrane protein
Pan181_RS02730	COG2815	serine threonine protein kinase
Pan181_RS02730	COG0515	serine threonine protein kinase
Pan181_RS02740	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Pan181_RS02765	COG0529	Catalyzes the synthesis of activated sulfate
Pan181_RS02785	COG1131	(ABC) transporter
Pan181_RS02790	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Pan181_RS02800	COG1663	tetraacyldisaccharide 4'-kinase activity
Pan181_RS02825	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Pan181_RS02865	COG0163	prenyltransferase activity
Pan181_RS02870	COG2226	methyltransferase
Pan181_RS02875	COG2045	Belongs to the ComB family
Pan181_RS02880	COG0423	glycine-tRNA ligase activity
Pan181_RS02895	COG2133	pyrroloquinoline quinone binding
Pan181_RS02910	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Pan181_RS02915	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Pan181_RS02920	COG0784	Response regulator, receiver
Pan181_RS02920	COG2205	protein histidine kinase activity
Pan181_RS02925	COG0328	RNA-DNA hybrid ribonuclease activity
Pan181_RS02930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Pan181_RS02955	COG1691	(AIR) carboxylase
Pan181_RS03015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Pan181_RS03055	COG4968	Prepilin-type N-terminal cleavage methylation domain
Pan181_RS03095	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Pan181_RS03100	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Pan181_RS03120	COG1449	Belongs to the glycosyl hydrolase 57 family
Pan181_RS03125	COG0840	transmembrane signaling receptor activity
Pan181_RS03130	COG1234	tRNA 3'-trailer cleavage
Pan181_RS03145	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
Pan181_RS03165	COG0457	Tetratricopeptide repeat
Pan181_RS03165	COG0515	serine threonine protein kinase
Pan181_RS03180	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Pan181_RS03215	COG2096	Adenosyltransferase
Pan181_RS03240	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Pan181_RS03245	COG1090	epimerase
Pan181_RS03280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Pan181_RS03290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Pan181_RS03300	COG0508	dehydrogenase complex catalyzes the overall conversion of
Pan181_RS03370	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Pan181_RS03390	COG0438	transferase activity, transferring glycosyl groups
Pan181_RS03395	COG0438	transferase activity, transferring glycosyl groups
Pan181_RS03415	COG1131	(ABC) transporter
Pan181_RS03445	COG0714	Associated with various cellular activities
Pan181_RS03485	COG0347	Belongs to the P(II) protein family
Pan181_RS03490	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Pan181_RS03505	COG0811	peptide transport
Pan181_RS03520	COG0242	peptide deformylase activity
Pan181_RS03530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Pan181_RS03540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Pan181_RS03560	COG0347	Belongs to the P(II) protein family
Pan181_RS03570	COG3119	arylsulfatase activity
Pan181_RS03585	COG1131	(ABC) transporter
Pan181_RS03605	COG0124	histidyl-tRNA synthetase
Pan181_RS03625	COG3119	arylsulfatase activity
Pan181_RS03645	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Pan181_RS03645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Pan181_RS03660	COG0196	riboflavin kinase activity
Pan181_RS03675	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Pan181_RS03685	COG1229	Formylmethanofuran dehydrogenase subunit A
Pan181_RS03710	COG0058	SHG alpha-glucan phosphorylase activity
Pan181_RS03720	COG1515	deoxyribonuclease V activity
Pan181_RS03725	COG0438	transferase activity, transferring glycosyl groups
Pan181_RS03750	COG1819	glycosyl
Pan181_RS03770	COG1595	DNA-templated transcription, initiation
Pan181_RS03780	COG4968	Prepilin-type N-terminal cleavage methylation domain
Pan181_RS03815	COG0095	Lipoate-protein ligase
Pan181_RS03825	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Pan181_RS03830	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Pan181_RS03835	COG0509	glycine decarboxylation via glycine cleavage system
Pan181_RS03840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Pan181_RS03845	COG0557	exoribonuclease II activity
Pan181_RS03855	COG1253	flavin adenine dinucleotide binding
Pan181_RS03860	COG3481	metal-dependent phosphohydrolase, HD sub domain
Pan181_RS03865	COG0442	prolyl-tRNA aminoacylation
Pan181_RS03870	COG1598	PFAM Uncharacterised protein family UPF0150
Pan181_RS03910	COG4372	Transposase
Pan181_RS03925	COG3119	arylsulfatase activity
Pan181_RS03935	COG0217	transcriptional regulatory protein
Pan181_RS03945	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Pan181_RS03950	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Pan181_RS03955	COG0195	Participates in both transcription termination and antitermination
Pan181_RS03965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Pan181_RS04015	COG2801	Transposase and inactivated derivatives
Pan181_RS04035	COG0445	tRNA wobble uridine modification
Pan181_RS04045	COG3240	lipase activity
Pan181_RS04055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Pan181_RS04060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Pan181_RS04065	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_RS04070	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Pan181_RS04075	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Pan181_RS04120	COG2255	four-way junction helicase activity
Pan181_RS04140	COG1073	alpha beta
Pan181_RS04145	COG1073	alpha beta
Pan181_RS04155	COG0632	four-way junction helicase activity
Pan181_RS04170	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Pan181_RS04175	COG0215	cysteine-tRNA ligase activity
Pan181_RS04180	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Pan181_RS04190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Pan181_RS04225	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Pan181_RS04240	COG4284	Utp--glucose-1-phosphate uridylyltransferase
Pan181_RS04245	COG1994	Peptidase M50
Pan181_RS04260	COG0489	protein tyrosine kinase activity
Pan181_RS04290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Pan181_RS04305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Pan181_RS04310	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Pan181_RS04325	COG0352	thiamine-phosphate diphosphorylase activity
Pan181_RS04335	COG0542	response to heat
Pan181_RS04345	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Pan181_RS04350	COG1127	ABC transporter
Pan181_RS04375	COG3852	Histidine kinase
Pan181_RS04385	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Pan181_RS04390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_RS04400	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Pan181_RS04405	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Pan181_RS04410	COG4651	solute:proton antiporter activity
Pan181_RS04410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Pan181_RS04420	COG4536	flavin adenine dinucleotide binding
Pan181_RS04460	COG1752	Esterase of the alpha-beta hydrolase superfamily
Pan181_RS04465	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Pan181_RS04470	COG0573	inorganic phosphate transmembrane transporter activity
Pan181_RS04475	COG0581	inorganic phosphate transmembrane transporter activity
Pan181_RS04480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Pan181_RS04485	COG0704	Plays a role in the regulation of phosphate uptake
Pan181_RS04490	COG0745	RESPONSE REGULATOR receiver
Pan181_RS04515	COG1201	RNA secondary structure unwinding
Pan181_RS04565	COG0135	phosphoribosylanthranilate isomerase activity
Pan181_RS04600	COG1459	type II secretion system
Pan181_RS04605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan181_RS04610	COG1366	Belongs to the anti-sigma-factor antagonist family
Pan181_RS04615	COG5002	protein histidine kinase activity
Pan181_RS04625	COG4969	Belongs to the N-Me-Phe pilin family
Pan181_RS04630	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Pan181_RS04640	COG0515	serine threonine protein kinase
Pan181_RS04640	COG2815	serine threonine protein kinase
Pan181_RS04650	COG2814	Major facilitator Superfamily
Pan181_RS04665	COG2204	response regulator
Pan181_RS04670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Pan181_RS04680	COG0514	ATP-dependent DNA helicase (RecQ)
Pan181_RS04700	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_RS04710	COG0800	Aldolase
Pan181_RS04715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Pan181_RS04740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Pan181_RS04745	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Pan181_RS04755	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Pan181_RS04755	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Pan181_RS04760	COG1070	Carbohydrate kinase
Pan181_RS04775	COG4806	L-rhamnose isomerase
Pan181_RS04780	COG4977	sequence-specific DNA binding
Pan181_RS04810	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Pan181_RS04845	COG0515	serine threonine protein kinase
Pan181_RS04930	COG3344	reverse transcriptase
Pan181_RS04935	COG2860	membrane
Pan181_RS04955	COG1704	LemA family
Pan181_RS04960	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Pan181_RS04965	COG1509	lysine 2,3-aminomutase activity
Pan181_RS04970	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Pan181_RS04985	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Pan181_RS05005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Pan181_RS05035	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Pan181_RS05050	COG2267	carboxylic ester hydrolase activity
Pan181_RS05065	COG1164	Oligoendopeptidase f
Pan181_RS05075	COG0534	Mate efflux family protein
Pan181_RS05135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Pan181_RS05190	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
Pan181_RS05265	COG0564	pseudouridine synthase activity
Pan181_RS05270	COG1970	mechanosensitive ion channel activity
Pan181_RS05275	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Pan181_RS05285	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Pan181_RS05290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Pan181_RS05315	COG2801	Transposase and inactivated derivatives
Pan181_RS05320	COG1741	Belongs to the pirin family
Pan181_RS05335	COG2373	Large extracellular alpha-helical protein
Pan181_RS05355	COG0284	orotidine-5'-phosphate decarboxylase activity
Pan181_RS05360	COG2153	protein acetylation
Pan181_RS05370	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Pan181_RS05385	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Pan181_RS05405	COG0129	dihydroxy-acid dehydratase activity
Pan181_RS05435	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Pan181_RS05440	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Pan181_RS05445	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Pan181_RS05450	COG1715	Restriction endonuclease
Pan181_RS05460	COG2081	HI0933 family
Pan181_RS05465	COG0571	ribonuclease III activity
Pan181_RS05470	COG1011	Hydrolase
Pan181_RS05475	COG0859	PFAM glycosyl transferase family 9
Pan181_RS05495	COG2738	Putative neutral zinc metallopeptidase
Pan181_RS05505	COG2104	thiamine diphosphate biosynthetic process
Pan181_RS05510	COG2022	thiamine diphosphate biosynthetic process
Pan181_RS05515	COG1199	ATP-dependent helicase activity
Pan181_RS05525	COG4912	Dna alkylation repair
Pan181_RS05530	COG0107	imidazoleglycerol-phosphate synthase activity
Pan181_RS05535	COG3507	Belongs to the glycosyl hydrolase 43 family
Pan181_RS05565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan181_RS05600	COG3132	Protein of unknown function, DUF480
Pan181_RS05610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Pan181_RS05620	COG0443	Heat shock 70 kDa protein
Pan181_RS05635	COG1902	pentaerythritol trinitrate reductase activity
Pan181_RS05645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Pan181_RS05650	COG0508	dehydrogenase complex catalyzes the overall conversion of
Pan181_RS05660	COG2207	Transcriptional regulator
Pan181_RS05660	COG0662	Cupin 2, conserved barrel domain protein
Pan181_RS05665	COG1064	alcohol dehydrogenase
Pan181_RS05670	COG0667	Aldo Keto reductase
Pan181_RS05680	COG3250	beta-galactosidase activity
Pan181_RS05765	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Pan181_RS05805	COG0137	argininosuccinate synthase activity
Pan181_RS05865	COG0110	maltose O-acetyltransferase activity
Pan181_RS05915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Pan181_RS05945	COG1045	serine acetyltransferase
Pan181_RS05955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Pan181_RS05995	COG0438	transferase activity, transferring glycosyl groups
Pan181_RS06080	COG3119	arylsulfatase activity
Pan181_RS06085	COG0673	inositol 2-dehydrogenase activity
Pan181_RS06130	COG2815	serine threonine protein kinase
Pan181_RS06130	COG0515	serine threonine protein kinase
Pan181_RS06150	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Pan181_RS06160	COG0318	PFAM AMP-dependent synthetase and ligase
Pan181_RS06170	COG0574	Belongs to the PEP-utilizing enzyme family
Pan181_RS06170	COG3848	Pyruvate phosphate dikinase
Pan181_RS06195	COG3693	PFAM glycoside hydrolase, family 10
Pan181_RS06195	COG3507	Belongs to the glycosyl hydrolase 43 family
Pan181_RS06195	COG2382	esterase
Pan181_RS06200	COG1063	alcohol dehydrogenase
Pan181_RS06205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Pan181_RS06260	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Pan181_RS06275	COG4191	Histidine kinase
Pan181_RS06285	COG2204	response regulator
Pan181_RS06300	COG0589	response to stress
Pan181_RS06315	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_RS06325	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Pan181_RS06345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Pan181_RS06350	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Pan181_RS06365	COG2239	Acts as a magnesium transporter
Pan181_RS06375	COG2322	membrane
Pan181_RS06390	COG0109	protoheme IX farnesyltransferase activity
Pan181_RS06405	COG0113	porphobilinogen synthase activity
Pan181_RS06410	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Pan181_RS06415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_RS06425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_RS06430	COG1796	DNA polymerase
Pan181_RS06430	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Pan181_RS06460	COG2010	Cytochrome c
Pan181_RS06465	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Pan181_RS06480	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Pan181_RS06490	COG0658	competence protein
Pan181_RS06515	COG0514	ATP-dependent DNA helicase (RecQ)
Pan181_RS06575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_RS06575	COG5549	protein import
Pan181_RS06580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Pan181_RS06595	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Pan181_RS06605	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Pan181_RS06620	COG1017	nitric oxide dioxygenase activity
Pan181_RS06620	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Pan181_RS06665	COG0517	IMP dehydrogenase activity
Pan181_RS06665	COG0516	GMP reductase activity
Pan181_RS06690	COG0222	ribosome binding
Pan181_RS06705	COG0469	pyruvate kinase activity
Pan181_RS06715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Pan181_RS06720	COG2770	Histidine kinase
Pan181_RS06720	COG3437	response regulator, receiver
Pan181_RS06740	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Pan181_RS06745	COG0142	geranyltranstransferase activity
Pan181_RS06750	COG1722	exodeoxyribonuclease VII activity
Pan181_RS06755	COG1570	exodeoxyribonuclease VII activity
Pan181_RS06765	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Pan181_RS06800	COG0037	tRNA processing
Pan181_RS06805	COG1418	mRNA catabolic process
Pan181_RS06810	COG1692	metallophosphoesterase
Pan181_RS06860	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Pan181_RS06910	COG0343	queuine tRNA-ribosyltransferase activity
Pan181_RS06920	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Pan181_RS06920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Pan181_RS06935	COG0784	Response regulator, receiver
Pan181_RS06935	COG2205	protein histidine kinase activity
Pan181_RS06935	COG2198	Histidine kinase
Pan181_RS06950	COG0714	Associated with various cellular activities
Pan181_RS06960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Pan181_RS06975	COG3335	DDE superfamily endonuclease
Pan181_RS06995	COG4191	Histidine kinase
Pan181_RS07005	COG3119	arylsulfatase activity
Pan181_RS07045	COG3384	dioxygenase
Pan181_RS07060	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Pan181_RS07065	COG4974	Belongs to the 'phage' integrase family
Pan181_RS07145	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Pan181_RS07150	COG1684	flagellar biosynthetic protein fliR
Pan181_RS07160	COG1338	Plays a role in the flagellum-specific transport system
Pan181_RS07210	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Pan181_RS07230	COG1157	protein secretion by the type III secretion system
Pan181_RS07250	COG1677	Flagellar hook-basal body complex protein FliE
Pan181_RS07255	COG1558	bacterial-type flagellum-dependent cell motility
Pan181_RS07260	COG1815	bacterial-type flagellum-dependent cell motility
Pan181_RS07270	COG3852	Histidine kinase
Pan181_RS07290	COG0039	L-malate dehydrogenase activity
Pan181_RS07295	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Pan181_RS07300	COG1419	protein localization to endoplasmic reticulum
Pan181_RS07315	COG1191	sigma factor activity
Pan181_RS07320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Pan181_RS07325	COG1078	dGTPase activity
Pan181_RS07335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Pan181_RS07335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Pan181_RS07340	COG1404	Belongs to the peptidase S8 family
Pan181_RS07345	COG3958	Transketolase
Pan181_RS07350	COG3959	Transketolase, thiamine diphosphate binding domain
Pan181_RS07355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Pan181_RS07360	COG0438	transferase activity, transferring glycosyl groups
Pan181_RS07380	COG0667	Aldo Keto reductase
Pan181_RS07405	COG0489	protein tyrosine kinase activity
Pan181_RS07485	COG0235	Class ii aldolase
Pan181_RS07490	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Pan181_RS07495	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Pan181_RS07500	COG0556	nucleotide-excision repair
Pan181_RS07515	COG3977	Valine--pyruvate aminotransferase
Pan181_RS07530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Pan181_RS07555	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Pan181_RS07560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Pan181_RS07565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Pan181_RS07585	COG3119	arylsulfatase activity
Pan181_RS07615	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Pan181_RS07625	COG3119	arylsulfatase activity
Pan181_RS07640	COG3781	membrane
Pan181_RS07660	COG0519	Catalyzes the synthesis of GMP from XMP
Pan181_RS07660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Pan181_RS07665	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Pan181_RS07690	COG0488	(ABC) transporter
Pan181_RS07720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Pan181_RS07735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Pan181_RS07755	COG2211	Major facilitator Superfamily
Pan181_RS07785	COG0295	cytidine deaminase activity
Pan181_RS07790	COG0275	rRNA processing
Pan181_RS07800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Pan181_RS07815	COG1410	methionine synthase
Pan181_RS07815	COG0646	methionine synthase
Pan181_RS07860	COG2165	general secretion pathway protein
Pan181_RS07885	COG1459	type II secretion system
Pan181_RS07890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan181_RS07930	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Pan181_RS07940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Pan181_RS07955	COG1136	(ABC) transporter
Pan181_RS07965	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Pan181_RS07995	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Pan181_RS08020	COG4566	intracellular signal transduction
Pan181_RS08025	COG4566	intracellular signal transduction
Pan181_RS08030	COG4191	Histidine kinase
Pan181_RS08040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Pan181_RS08050	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Pan181_RS08080	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Pan181_RS08130	COG2197	response regulator
Pan181_RS08165	COG4537	Required for transformation and DNA binding
Pan181_RS08170	COG3401	FG-GAP repeat protein
Pan181_RS08175	COG3401	FG-GAP repeat protein
Pan181_RS08250	COG1442	glycosyl transferase family 8
Pan181_RS08260	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Pan181_RS08265	COG1185	polyribonucleotide nucleotidyltransferase activity
Pan181_RS08270	COG4191	Histidine kinase
Pan181_RS08285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Pan181_RS08290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Pan181_RS08335	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Pan181_RS08350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Pan181_RS08355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Pan181_RS08370	COG0148	phosphopyruvate hydratase activity
Pan181_RS08390	COG0318	PFAM AMP-dependent synthetase and ligase
Pan181_RS08415	COG1674	ftsk spoiiie
Pan181_RS08420	COG0045	succinate-CoA ligase (ADP-forming) activity
Pan181_RS08425	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Pan181_RS08475	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Pan181_RS08480	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Pan181_RS08510	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Pan181_RS08525	COG0202	RNA polymerase activity
Pan181_RS08540	COG1560	Kdo2-lipid A biosynthetic process
Pan181_RS08550	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Pan181_RS08555	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Pan181_RS08565	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Pan181_RS08585	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Pan181_RS08590	COG0802	atpase or kinase
Pan181_RS08630	COG0584	glycerophosphoryl diester phosphodiesterase
Pan181_RS08640	COG0363	glucosamine-6-phosphate deaminase activity
Pan181_RS08645	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Pan181_RS08650	COG0673	inositol 2-dehydrogenase activity
Pan181_RS08670	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Pan181_RS08685	COG0745	RESPONSE REGULATOR receiver
Pan181_RS08695	COG0745	RESPONSE REGULATOR receiver
Pan181_RS08735	COG1716	ATPase activity
Pan181_RS08740	COG3119	arylsulfatase activity
Pan181_RS08755	COG0793	Belongs to the peptidase S41A family
Pan181_RS08760	COG0321	lipoyl(octanoyl) transferase activity
Pan181_RS08760	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Pan181_RS08765	COG0653	protein targeting
Pan181_RS08770	COG1519	Transferase
Pan181_RS08785	COG1131	(ABC) transporter
Pan181_RS08795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Pan181_RS08810	COG0473	3-isopropylmalate dehydrogenase activity
Pan181_RS08815	COG2815	serine threonine protein kinase
Pan181_RS08815	COG0515	serine threonine protein kinase
Pan181_RS08820	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Pan181_RS08840	COG0590	tRNA wobble adenosine to inosine editing
Pan181_RS08865	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Pan181_RS08870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Pan181_RS08875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Pan181_RS08890	COG3253	May function as heme-dependent peroxidase
Pan181_RS08920	COG3119	arylsulfatase activity
Pan181_RS08935	COG2801	Transposase and inactivated derivatives
Pan181_RS08980	COG0726	polysaccharide deacetylase
Pan181_RS09005	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Pan181_RS09020	COG2843	Capsule synthesis protein
Pan181_RS09080	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Pan181_RS09115	COG3852	Histidine kinase
Pan181_RS09180	COG0714	Associated with various cellular activities
Pan181_RS09185	COG3552	Protein containing von Willebrand factor type A (VWA) domain
Pan181_RS09190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Pan181_RS09260	COG0363	glucosamine-6-phosphate deaminase activity
Pan181_RS09275	COG3485	protocatechuate 3,4-dioxygenase
Pan181_RS09280	COG0778	Nitroreductase
Pan181_RS09285	COG1459	type II secretion system
Pan181_RS09305	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Pan181_RS09315	COG2818	Glycosylase
Pan181_RS09320	COG0445	tRNA wobble uridine modification
Pan181_RS09355	COG2217	Heavy metal translocating P-type atpase
Pan181_RS09365	COG0348	domain, Protein
Pan181_RS09370	COG2010	Cytochrome c
Pan181_RS09380	COG3278	Belongs to the heme-copper respiratory oxidase family
Pan181_RS09395	COG2832	Protein of unknown function (DUF454)
Pan181_RS09400	COG2855	membrane
Pan181_RS09415	COG0738	Major facilitator superfamily
Pan181_RS09425	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Pan181_RS09430	COG3118	belongs to the thioredoxin family
Pan181_RS09445	COG0471	metal ion transport
Pan181_RS09445	COG3273	potassium ion transport
Pan181_RS09545	COG0393	Putative heavy-metal-binding
Pan181_RS09560	COG0464	growth
Pan181_RS09565	COG2197	response regulator
Pan181_RS09585	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Pan181_RS09595	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Pan181_RS09600	COG0006	proline dipeptidase activity
Pan181_RS09610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Pan181_RS09615	COG0066	3-isopropylmalate dehydratase activity
Pan181_RS09635	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Pan181_RS09665	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Pan181_RS09690	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Pan181_RS09715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_RS09720	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Pan181_RS09740	COG3335	DDE superfamily endonuclease
Pan181_RS09760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Pan181_RS09785	COG0101	tRNA pseudouridine synthase activity
Pan181_RS09795	COG3335	DDE superfamily endonuclease
Pan181_RS09810	COG2815	serine threonine protein kinase
Pan181_RS09810	COG0515	serine threonine protein kinase
Pan181_RS09815	COG0825	malonyl-CoA metabolic process
Pan181_RS09885	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Pan181_RS09920	COG0436	Aminotransferase
Pan181_RS09995	COG2207	Transcriptional regulator
Pan181_RS09995	COG1609	Transcriptional regulator
Pan181_RS10080	COG3250	beta-galactosidase activity
Pan181_RS10165	COG0515	serine threonine protein kinase
Pan181_RS10180	COG3481	metal-dependent phosphohydrolase, HD sub domain
Pan181_RS10190	COG2890	protein-(glutamine-N5) methyltransferase activity
Pan181_RS10195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Pan181_RS10200	COG0254	rRNA binding
Pan181_RS10225	COG2801	Transposase and inactivated derivatives
Pan181_RS10245	COG0443	Heat shock 70 kDa protein
Pan181_RS10255	COG2267	carboxylic ester hydrolase activity
Pan181_RS10290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Pan181_RS10300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_RS10320	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Pan181_RS10325	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Pan181_RS10330	COG0602	queuosine metabolic process
Pan181_RS10345	COG0151	Belongs to the GarS family
Pan181_RS10365	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Pan181_RS10380	COG2226	methyltransferase
Pan181_RS10395	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Pan181_RS10395	COG0167	dihydroorotate dehydrogenase activity
Pan181_RS10410	COG1505	serine-type exopeptidase activity
Pan181_RS10420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Pan181_RS10450	COG0848	biopolymer transport protein
Pan181_RS10455	COG0811	peptide transport
Pan181_RS10480	COG0745	RESPONSE REGULATOR receiver
Pan181_RS10485	COG3852	Histidine kinase
Pan181_RS10525	COG0166	Belongs to the GPI family
Pan181_RS10530	COG1045	serine acetyltransferase
Pan181_RS10535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Pan181_RS10545	COG1678	Uncharacterized ACR, COG1678
Pan181_RS10560	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Pan181_RS10565	COG2326	polyphosphate kinase activity
Pan181_RS10580	COG1940	carbohydrate kinase activity
Pan181_RS10585	COG3119	arylsulfatase activity
Pan181_RS10625	COG3119	arylsulfatase activity
Pan181_RS10630	COG3119	arylsulfatase activity
Pan181_RS10635	COG3250	beta-galactosidase activity
Pan181_RS10655	COG4409	exo-alpha-(2->6)-sialidase activity
Pan181_RS10695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Pan181_RS10700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Pan181_RS10720	COG3250	beta-galactosidase activity
Pan181_RS10750	COG2160	L-arabinose isomerase activity
Pan181_RS10760	COG1069	ribulokinase activity
Pan181_RS10790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_RS10795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_RS10800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_RS10840	COG0714	Associated with various cellular activities
Pan181_RS10855	COG0776	regulation of translation
Pan181_RS10880	COG5001	Diguanylate cyclase
Pan181_RS10885	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Pan181_RS10915	COG1215	transferase activity, transferring glycosyl groups
Pan181_RS10930	COG1215	transferase activity, transferring glycosyl groups
Pan181_RS10935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Pan181_RS10950	COG1477	protein flavinylation
Pan181_RS10965	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Pan181_RS10970	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Pan181_RS10975	COG1805	sodium ion transport
Pan181_RS11005	COG3119	arylsulfatase activity
Pan181_RS11015	COG3119	arylsulfatase activity
Pan181_RS11045	COG0515	serine threonine protein kinase
Pan181_RS11045	COG2815	serine threonine protein kinase
Pan181_RS11055	COG2207	Transcriptional regulator
Pan181_RS11075	COG1595	DNA-templated transcription, initiation
Pan181_RS11080	COG2815	serine threonine protein kinase
Pan181_RS11080	COG0515	serine threonine protein kinase
Pan181_RS11135	COG3119	arylsulfatase activity
Pan181_RS11165	COG3005	denitrification pathway
Pan181_RS11170	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
Pan181_RS11175	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Pan181_RS11345	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Pan181_RS11370	COG1361	Conserved repeat domain
Pan181_RS11480	COG0811	peptide transport
Pan181_RS11485	COG0848	biopolymer transport protein
Pan181_RS11495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Pan181_RS11500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Pan181_RS11520	COG2207	Transcriptional regulator
Pan181_RS11520	COG1609	Transcriptional regulator
Pan181_RS11545	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Pan181_RS11605	COG3119	arylsulfatase activity
Pan181_RS11650	COG0784	Response regulator, receiver
Pan181_RS11650	COG4191	Histidine kinase
Pan181_RS11670	COG3401	FG-GAP repeat protein
Pan181_RS11715	COG0473	3-isopropylmalate dehydrogenase activity
Pan181_RS11735	COG0268	Binds directly to 16S ribosomal RNA
Pan181_RS11745	COG1187	pseudouridine synthase activity
Pan181_RS11760	COG2936	dipeptidyl-peptidase activity
Pan181_RS11790	COG0805	protein transport
Pan181_RS11795	COG1482	cell wall glycoprotein biosynthetic process
Pan181_RS11805	COG0584	glycerophosphoryl diester phosphodiesterase
Pan181_RS11835	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Pan181_RS11850	COG3706	GGDEF domain
Pan181_RS11920	COG1012	belongs to the aldehyde dehydrogenase family
Pan181_RS11935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Pan181_RS11970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Pan181_RS11980	COG0471	metal ion transport
Pan181_RS12010	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Pan181_RS12025	COG2340	Cysteine-rich secretory protein family
Pan181_RS12040	COG3537	Alpha-1,2-mannosidase
Pan181_RS12055	COG0038	chloride channel
Pan181_RS12060	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Pan181_RS12065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Pan181_RS12115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Pan181_RS12125	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Pan181_RS12135	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_RS12140	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Pan181_RS12170	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Pan181_RS12195	COG0131	Imidazoleglycerol-phosphate dehydratase
Pan181_RS12205	COG0205	6-phosphofructokinase activity
Pan181_RS12210	COG0439	Biotin carboxylase
Pan181_RS12215	COG0511	ligase activity, forming carbon-carbon bonds
Pan181_RS12220	COG0006	proline dipeptidase activity
Pan181_RS12250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Pan181_RS12255	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Pan181_RS12260	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Pan181_RS12265	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Pan181_RS12285	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Pan181_RS12290	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Pan181_RS12305	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Pan181_RS12330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Pan181_RS12330	COG3153	acetyltransferase
Pan181_RS12340	COG1606	tRNA processing
Pan181_RS12350	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Pan181_RS12350	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Pan181_RS12355	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Pan181_RS12360	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Pan181_RS12365	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Pan181_RS12370	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Pan181_RS12375	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Pan181_RS12380	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Pan181_RS12385	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Pan181_RS12390	COG0356	it plays a direct role in the translocation of protons across the membrane
Pan181_RS12410	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Pan181_RS12430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Pan181_RS12440	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Pan181_RS12445	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_RS12460	COG0004	ammonium transporteR
Pan181_RS12465	COG0552	protein localization to endoplasmic reticulum
Pan181_RS12470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Pan181_RS12480	COG2226	methyltransferase
Pan181_RS12520	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Pan181_RS12525	COG0237	dephospho-CoA kinase activity
Pan181_RS12530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Pan181_RS12530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Pan181_RS12575	COG1082	Xylose isomerase domain protein TIM barrel
Pan181_RS12595	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Pan181_RS12600	COG1333	cytochrome c biogenesis protein
Pan181_RS12600	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Pan181_RS12620	COG0483	inositol monophosphate 1-phosphatase activity
Pan181_RS12630	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Pan181_RS12635	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Pan181_RS12645	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Pan181_RS12660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Pan181_RS12670	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Pan181_RS12680	COG1012	belongs to the aldehyde dehydrogenase family
Pan181_RS12700	COG0575	Belongs to the CDS family
Pan181_RS12710	COG0438	transferase activity, transferring glycosyl groups
Pan181_RS12715	COG2244	polysaccharide biosynthetic process
Pan181_RS12755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Pan181_RS12775	COG0653	protein targeting
Pan181_RS12800	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Pan181_RS12815	COG1131	(ABC) transporter
Pan181_RS12830	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Pan181_RS12835	COG4555	ABC transporter
Pan181_RS12845	COG0402	S-adenosylhomocysteine deaminase activity
Pan181_RS12860	COG0659	secondary active sulfate transmembrane transporter activity
Pan181_RS12885	COG0673	inositol 2-dehydrogenase activity
Pan181_RS12895	COG0424	maF-like protein
Pan181_RS12900	COG0564	pseudouridine synthase activity
Pan181_RS12905	COG2815	serine threonine protein kinase
Pan181_RS12905	COG0515	serine threonine protein kinase
Pan181_RS12910	COG4106	trans-aconitate 2-methyltransferase activity
Pan181_RS12915	COG0596	Alpha beta hydrolase
Pan181_RS12920	COG0156	8-amino-7-oxononanoate synthase activity
Pan181_RS12935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Pan181_RS12940	COG1115	amino acid carrier protein
Pan181_RS12950	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Pan181_RS12955	COG0396	ATPase activity
Pan181_RS12960	COG0719	Fe-S assembly protein
Pan181_RS12965	COG0719	Fe-S assembly protein
Pan181_RS13015	COG0848	biopolymer transport protein
Pan181_RS13035	COG0544	peptidyl-prolyl cis-trans isomerase activity
Pan181_RS13055	COG4948	Mandelate Racemase Muconate Lactonizing
Pan181_RS13085	COG2207	Transcriptional regulator
Pan181_RS13085	COG1609	Transcriptional regulator
Pan181_RS13090	COG0509	glycine decarboxylation via glycine cleavage system
Pan181_RS13095	COG0523	cobalamin synthesis protein
Pan181_RS13110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Pan181_RS13115	COG0142	geranyltranstransferase activity
Pan181_RS13130	COG1104	cysteine desulfurase activity
Pan181_RS13135	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Pan181_RS13180	COG0714	Associated with various cellular activities
Pan181_RS13185	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
Pan181_RS13190	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
Pan181_RS13195	COG1335	isochorismatase
Pan181_RS13200	COG0494	nUDIX hydrolase
Pan181_RS13205	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Pan181_RS13215	COG0657	acetylesterase activity
Pan181_RS13295	COG4191	Histidine kinase
Pan181_RS13295	COG0784	Response regulator, receiver
Pan181_RS13355	COG2204	response regulator
Pan181_RS13360	COG3852	Histidine kinase
Pan181_RS13375	COG1538	Outer membrane efflux protein
Pan181_RS13385	COG3119	arylsulfatase activity
Pan181_RS13450	COG4650	regulator
Pan181_RS13465	COG0430	RNA-3'-phosphate cyclase activity
Pan181_RS13505	COG1942	4-Oxalocrotonate Tautomerase
Pan181_RS13540	COG1064	alcohol dehydrogenase
Pan181_RS13545	COG4221	oxidoreductase activity
Pan181_RS13550	COG2207	Transcriptional regulator
Pan181_RS13565	COG3507	Belongs to the glycosyl hydrolase 43 family
Pan181_RS13610	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_RS13620	COG1802	Transcriptional regulator
Pan181_RS13665	COG4941	Belongs to the sigma-70 factor family
Pan181_RS13710	COG3458	cephalosporin-C deacetylase activity
Pan181_RS13715	COG4968	Prepilin-type N-terminal cleavage methylation domain
Pan181_RS13760	COG1012	belongs to the aldehyde dehydrogenase family
Pan181_RS13805	COG3119	arylsulfatase activity
Pan181_RS14055	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Pan181_RS14060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Pan181_RS14065	COG1111	helicase
Pan181_RS14065	COG1205	dead DEAH box helicase
Pan181_RS14105	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Pan181_RS14115	COG2801	Transposase and inactivated derivatives
Pan181_RS14165	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Pan181_RS14170	COG0583	DNA-binding transcription factor activity
Pan181_RS14175	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Pan181_RS14185	COG0123	including yeast histone deacetylase and acetoin utilization protein
Pan181_RS14210	COG4122	O-methyltransferase activity
Pan181_RS14215	COG2124	cytochrome p450
Pan181_RS14235	COG1397	ADP-ribosylglycohydrolase
Pan181_RS14255	COG0701	Predicted permease
Pan181_RS14265	COG2115	Belongs to the xylose isomerase family
Pan181_RS14295	COG1349	DNA-binding transcription factor activity
Pan181_RS14300	COG4869	propanediol catabolic process
Pan181_RS14305	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Pan181_RS14315	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Pan181_RS14345	COG0235	Class ii aldolase
Pan181_RS14350	COG0039	L-malate dehydrogenase activity
Pan181_RS14385	COG0105	UTP biosynthetic process
Pan181_RS14390	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Pan181_RS14395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Pan181_RS14405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Pan181_RS14410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Pan181_RS14410	COG1321	iron dependent repressor
Pan181_RS14415	COG1121	(ABC) transporter
Pan181_RS14420	COG0803	Belongs to the bacterial solute-binding protein 9 family
Pan181_RS14430	COG0612	Peptidase, M16
Pan181_RS14450	COG2217	Heavy metal translocating P-type atpase
Pan181_RS14475	COG4977	sequence-specific DNA binding
Pan181_RS14480	COG0543	2 iron, 2 sulfur cluster binding
Pan181_RS14485	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Pan181_RS14485	COG0493	'glutamate synthase
Pan181_RS14490	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_RS14505	COG0674	pyruvate-flavodoxin oxidoreductase activity
Pan181_RS14505	COG1013	pyruvate-flavodoxin oxidoreductase activity
Pan181_RS14505	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Pan181_RS14505	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Pan181_RS14520	COG3243	poly(R)-hydroxyalkanoic acid synthase
Pan181_RS14525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Pan181_RS14530	COG4770	biotin carboxylase activity
Pan181_RS14540	COG2755	lipolytic protein G-D-S-L family
Pan181_RS14550	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Pan181_RS14555	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Pan181_RS14560	COG4770	biotin carboxylase activity
Pan181_RS14575	COG1703	isobutyryl-CoA mutase activity
Pan181_RS14595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Pan181_RS14600	COG3243	poly(R)-hydroxyalkanoic acid synthase
Pan181_RS14615	COG0183	Belongs to the thiolase family
Pan181_RS14630	COG3119	arylsulfatase activity
Pan181_RS14690	COG3119	arylsulfatase activity
Pan181_RS14695	COG3119	arylsulfatase activity
Pan181_RS14705	COG4968	Prepilin-type N-terminal cleavage methylation domain
Pan181_RS14730	COG3119	arylsulfatase activity
Pan181_RS14735	COG2814	Major facilitator Superfamily
Pan181_RS14770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Pan181_RS14780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Pan181_RS14785	COG0673	inositol 2-dehydrogenase activity
Pan181_RS14790	COG1250	3-hydroxyacyl-CoA dehydrogenase
Pan181_RS14800	COG1609	Transcriptional regulator
Pan181_RS14835	COG2188	Transcriptional regulator
Pan181_RS14840	COG5285	phytanoyl-CoA dioxygenase
Pan181_RS14860	COG0006	proline dipeptidase activity
Pan181_RS14925	COG0438	transferase activity, transferring glycosyl groups
Pan181_RS14935	COG2204	response regulator
Pan181_RS14945	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Pan181_RS14950	COG1091	dTDP-4-dehydrorhamnose reductase activity
Pan181_RS14960	COG3119	arylsulfatase activity
Pan181_RS14965	COG2706	6-phosphogluconolactonase activity
Pan181_RS14995	COG2204	response regulator
Pan181_RS15000	COG2814	Major facilitator Superfamily
Pan181_RS15020	COG1846	Transcriptional regulator
Pan181_RS15045	COG2304	oxidoreductase activity
Pan181_RS15060	COG0714	Associated with various cellular activities
Pan181_RS15080	COG3408	Glycogen debranching enzyme
Pan181_RS15080	COG3119	arylsulfatase activity
Pan181_RS15095	COG2165	general secretion pathway protein
Pan181_RS15120	COG4948	Mandelate Racemase Muconate Lactonizing
Pan181_RS15140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Pan181_RS15145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Pan181_RS15210	COG2814	Major facilitator Superfamily
Pan181_RS15230	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_RS15235	COG4948	Mandelate Racemase Muconate Lactonizing
Pan181_RS15240	COG0738	Major facilitator superfamily
Pan181_RS15245	COG3618	amidohydrolase
Pan181_RS15250	COG1063	alcohol dehydrogenase
Pan181_RS15275	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Pan181_RS15275	COG0515	serine threonine protein kinase
Pan181_RS15280	COG2115	Belongs to the xylose isomerase family
Pan181_RS15290	COG2169	Transcriptional regulator
Pan181_RS15315	COG1609	Transcriptional regulator
Pan181_RS15315	COG2207	Transcriptional regulator
Pan181_RS15330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Pan181_RS15335	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Pan181_RS15365	COG3119	arylsulfatase activity
Pan181_RS15470	COG1518	maintenance of DNA repeat elements
Pan181_RS15475	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Pan181_RS15540	COG2815	serine threonine protein kinase
Pan181_RS15540	COG0515	serine threonine protein kinase
Pan181_RS15570	COG1396	sequence-specific DNA binding
Pan181_RS15575	COG2207	Transcriptional regulator
Pan181_RS15575	COG1609	Transcriptional regulator
Pan181_RS15580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Pan181_RS15585	COG0247	lactate metabolic process
Pan181_RS15585	COG2181	nitrate reductase activity
Pan181_RS15595	COG2086	electron transfer activity
Pan181_RS15635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Pan181_RS15640	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Pan181_RS15650	COG1872	DUF167
Pan181_RS15690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Pan181_RS15705	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Pan181_RS15720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_RS15730	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Pan181_RS15750	COG0626	cystathionine gamma-synthase activity
Pan181_RS15755	COG0180	Tryptophanyl-tRNA synthetase
Pan181_RS15760	COG0167	dihydroorotate dehydrogenase activity
Pan181_RS15775	COG0727	PFAM Uncharacterised protein family (UPF0153)
Pan181_RS15785	COG0314	molybdopterin synthase activity
Pan181_RS15825	COG0277	FAD linked oxidase domain protein
Pan181_RS15825	COG0247	lactate metabolic process
Pan181_RS15830	COG0302	gtp cyclohydrolase
Pan181_RS15845	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Pan181_RS15890	COG0788	formyltetrahydrofolate deformylase activity
Pan181_RS15910	COG0617	tRNA 3'-terminal CCA addition
Pan181_RS15910	COG0517	IMP dehydrogenase activity
Pan181_RS15910	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Pan181_RS15925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan181_RS15935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan181_RS15940	COG1459	type II secretion system
Pan181_RS15985	COG1450	Type ii and iii secretion system protein
Pan181_RS16000	COG1131	(ABC) transporter
Pan181_RS16035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Pan181_RS16065	COG3119	arylsulfatase activity
Pan181_RS16125	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Pan181_RS16130	COG0515	serine threonine protein kinase
Pan181_RS16130	COG2815	serine threonine protein kinase
Pan181_RS16135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Pan181_RS16150	COG0693	protein deglycase activity
Pan181_RS16155	COG0824	Thioesterase
Pan181_RS16170	COG1078	dGTPase activity
Pan181_RS16200	COG4191	Histidine kinase
Pan181_RS16230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Pan181_RS16235	COG3021	interspecies interaction between organisms
Pan181_RS16250	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Pan181_RS16250	COG0116	Belongs to the methyltransferase superfamily
Pan181_RS16260	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Pan181_RS16260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Pan181_RS16265	COG1546	Belongs to the CinA family
Pan181_RS16265	COG1058	Belongs to the CinA family
Pan181_RS16270	COG1233	COG1233 Phytoene dehydrogenase and related
Pan181_RS16275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Pan181_RS16280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Pan181_RS16285	COG1070	Carbohydrate kinase
Pan181_RS16315	COG1254	Belongs to the acylphosphatase family
Pan181_RS16340	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Pan181_RS16355	COG2207	Transcriptional regulator
Pan181_RS16355	COG1609	Transcriptional regulator
Pan181_RS16375	COG2207	Transcriptional regulator
Pan181_RS16375	COG1609	Transcriptional regulator
Pan181_RS16385	COG0156	8-amino-7-oxononanoate synthase activity
Pan181_RS16390	COG5505	Protein of unknown function (DUF819)
Pan181_RS16400	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Pan181_RS16450	COG0445	tRNA wobble uridine modification
Pan181_RS16460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Pan181_RS16495	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Pan181_RS16505	COG3335	DDE superfamily endonuclease
Pan181_RS16580	COG1321	iron dependent repressor
Pan181_RS16600	COG0463	Glycosyl transferase, family 2
Pan181_RS16635	COG0673	inositol 2-dehydrogenase activity
Pan181_RS16640	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Pan181_RS16655	COG2234	aminopeptidase activity
Pan181_RS16660	COG0784	Response regulator, receiver
Pan181_RS16665	COG3852	Histidine kinase
Pan181_RS16670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Pan181_RS16690	COG4717	serine-type aminopeptidase activity
Pan181_RS16695	COG0564	pseudouridine synthase activity
Pan181_RS16700	COG0300	oxidoreductase activity
Pan181_RS16705	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Pan181_RS16730	COG2815	serine threonine protein kinase
Pan181_RS16730	COG0515	serine threonine protein kinase
Pan181_RS16745	COG0673	inositol 2-dehydrogenase activity
Pan181_RS16750	COG0745	RESPONSE REGULATOR receiver
Pan181_RS16755	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Pan181_RS16765	COG2308	Evidence 4 Homologs of previously reported genes of
Pan181_RS16780	COG2307	Protein conserved in bacteria
Pan181_RS16780	COG2308	Evidence 4 Homologs of previously reported genes of
Pan181_RS16790	COG1115	amino acid carrier protein
Pan181_RS16810	COG0606	chelatase, subunit chli
Pan181_RS16830	COG2095	MarC family integral membrane protein
Pan181_RS16850	COG1858	cytochrome C peroxidase
Pan181_RS16865	COG2272	Belongs to the type-B carboxylesterase lipase family
Pan181_RS16880	COG4112	unkown
Pan181_RS16915	COG0275	rRNA processing
Pan181_RS16925	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Pan181_RS16930	COG0784	Response regulator, receiver
Pan181_RS16935	COG4251	negative regulation of phosphorylation
Pan181_RS16940	COG0745	RESPONSE REGULATOR receiver
Pan181_RS16945	COG0745	RESPONSE REGULATOR receiver
Pan181_RS16950	COG2205	protein histidine kinase activity
Pan181_RS16955	COG0745	RESPONSE REGULATOR receiver
Pan181_RS16965	COG0316	Belongs to the HesB IscA family
Pan181_RS16975	COG1104	cysteine desulfurase activity
Pan181_RS16980	COG3119	arylsulfatase activity
Pan181_RS17020	COG0538	isocitrate dehydrogenase activity
Pan181_RS17065	COG3119	arylsulfatase activity
Pan181_RS17115	COG4948	Mandelate Racemase Muconate Lactonizing
Pan181_RS17125	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Pan181_RS17130	COG3142	Participates in the control of copper homeostasis
Pan181_RS17255	COG3541	Predicted nucleotidyltransferase
Pan181_RS17280	COG1242	4 iron, 4 sulfur cluster binding
Pan181_RS17290	COG1162	GTPase activity
Pan181_RS17350	COG1090	epimerase
Pan181_RS17375	COG4464	protein tyrosine phosphatase activity
Pan181_RS17385	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Pan181_RS17390	COG0357	Ribosomal RNA small subunit methyltransferase G
Pan181_RS17405	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Pan181_RS17410	COG0315	cyclic pyranopterin monophosphate synthase activity
Pan181_RS17415	COG0142	geranyltranstransferase activity
Pan181_RS17425	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Pan181_RS17430	COG0140	phosphoribosyl-ATP diphosphatase activity
Pan181_RS17440	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Pan181_RS17455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Pan181_RS17455	COG0426	domain, Protein
Pan181_RS17460	COG0579	oxidoreductase
Pan181_RS17490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Pan181_RS17510	COG1706	bacterial-type flagellum-dependent cell motility
Pan181_RS17515	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Pan181_RS17525	COG4786	Flagellar basal body rod
Pan181_RS17530	COG4786	Flagellar basal body rod
Pan181_RS17535	COG0617	tRNA 3'-terminal CCA addition
Pan181_RS17545	COG2095	MarC family integral membrane protein
Pan181_RS17570	COG0569	domain protein
Pan181_RS17585	COG1131	(ABC) transporter
Pan181_RS17590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Pan181_RS17595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Pan181_RS17600	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Pan181_RS17605	COG0667	Aldo Keto reductase
Pan181_RS17610	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Pan181_RS17625	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Pan181_RS17635	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Pan181_RS17640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Pan181_RS17645	COG0649	NAD binding
Pan181_RS17650	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Pan181_RS17655	COG0839	Belongs to the complex I subunit 6 family
Pan181_RS17660	COG0713	ATP synthesis coupled electron transport
Pan181_RS17665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Pan181_RS17675	COG1007	ATP synthesis coupled electron transport
Pan181_RS17695	COG0084	hydrolase, TatD family'
Pan181_RS17720	COG3408	Glycogen debranching enzyme
Pan181_RS17730	COG3119	arylsulfatase activity
Pan181_RS17735	COG1063	alcohol dehydrogenase
Pan181_RS17760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Pan181_RS17765	COG0798	PFAM Bile acid sodium symporter
Pan181_RS17775	COG0640	Transcriptional regulator
Pan181_RS17780	COG0701	Predicted permease
Pan181_RS17860	COG0542	response to heat
Pan181_RS17950	COG3335	DDE superfamily endonuclease
Pan181_RS17985	COG2801	Transposase and inactivated derivatives
Pan181_RS18005	COG0653	protein targeting
Pan181_RS18105	COG0405	Gamma-glutamyltransferase
Pan181_RS18120	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Pan181_RS18125	COG2971	BadF BadG BcrA BcrD
Pan181_RS18130	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Pan181_RS18135	COG1609	Transcriptional regulator
Pan181_RS18135	COG2207	Transcriptional regulator
Pan181_RS18140	COG1649	PFAM Uncharacterised BCR, COG1649
Pan181_RS18145	COG2814	Major facilitator Superfamily
Pan181_RS18155	COG1472	Belongs to the glycosyl hydrolase 3 family
Pan181_RS18165	COG4948	Mandelate Racemase Muconate Lactonizing
Pan181_RS18185	COG2715	membrane protein required for spore maturation
Pan181_RS18190	COG0700	Nucleoside recognition
Pan181_RS18195	COG1619	proteins homologs of microcin C7 resistance protein MccF
Pan181_RS18200	COG1619	proteins homologs of microcin C7 resistance protein MccF
Pan181_RS18210	COG0745	RESPONSE REGULATOR receiver
Pan181_RS18355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Pan181_RS18360	COG0175	sulfate reduction
Pan181_RS18365	COG1959	2 iron, 2 sulfur cluster binding
Pan181_RS18380	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Pan181_RS18405	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Pan181_RS18475	COG0793	Belongs to the peptidase S41A family
Pan181_RS18515	COG3119	arylsulfatase activity
Pan181_RS18540	COG0835	chemotaxis
Pan181_RS18560	COG1053	succinate dehydrogenase
Pan181_RS18565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Pan181_RS18575	COG1196	nuclear chromosome segregation
Pan181_RS18585	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Pan181_RS18590	COG0594	ribonuclease P activity
Pan181_RS18605	COG0515	serine threonine protein kinase
Pan181_RS18620	COG0470	DNA polymerase III
Pan181_RS18625	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Pan181_RS18635	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Pan181_RS18680	COG1136	(ABC) transporter
Pan181_RS18685	COG1136	(ABC) transporter
Pan181_RS18685	COG0577	efflux transmembrane transporter activity
Pan181_RS18690	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Pan181_RS18695	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Pan181_RS18695	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Pan181_RS18715	COG0673	inositol 2-dehydrogenase activity
Pan181_RS18755	COG0714	Associated with various cellular activities
Pan181_RS18775	COG0009	L-threonylcarbamoyladenylate synthase
Pan181_RS18780	COG0698	ribose 5-phosphate isomerase
Pan181_RS18785	COG2379	hydroxypyruvate reductase
Pan181_RS18830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Pan181_RS18840	COG4591	ABC-type transport system involved in lipoprotein release permease component
Pan181_RS18845	COG1136	(ABC) transporter
Pan181_RS18885	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Pan181_RS18890	COG4589	Belongs to the CDS family
Pan181_RS18895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Pan181_RS18900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Pan181_RS18905	COG0616	signal peptide processing
Pan181_RS18920	COG1040	competence protein
Pan181_RS18930	COG0181	hydroxymethylbilane synthase activity
Pan181_RS18935	COG3507	Belongs to the glycosyl hydrolase 43 family
Pan181_RS18950	COG4948	Mandelate Racemase Muconate Lactonizing
Pan181_RS18965	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Pan181_RS18995	COG2183	response to ionizing radiation
Pan181_RS18995	COG0539	negative regulation of cytoplasmic translation
Pan181_RS19020	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Pan181_RS19025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Pan181_RS19030	COG0569	domain protein
Pan181_RS19035	COG0305	Participates in initiation and elongation during chromosome replication
Pan181_RS19040	COG0359	binds to the 23S rRNA
Pan181_RS19045	COG0629	single-stranded DNA binding
Pan181_RS19050	COG0360	Binds together with S18 to 16S ribosomal RNA
Pan181_RS19055	COG0193	aminoacyl-tRNA hydrolase activity
Pan181_RS19060	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Pan181_RS19065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Pan181_RS19070	COG0318	PFAM AMP-dependent synthetase and ligase
Pan181_RS19085	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Pan181_RS19120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Pan181_RS19130	COG0287	Prephenate dehydrogenase
Pan181_RS19135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Pan181_RS19140	COG0047	phosphoribosylformylglycinamidine synthase activity
Pan181_RS19150	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Pan181_RS19155	COG0706	membrane insertase activity
Pan181_RS19155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_RS19165	COG1214	PFAM Peptidase M22, glycoprotease
Pan181_RS19185	COG1917	Cupin 2, conserved barrel domain protein
Pan181_RS19185	COG2207	Transcriptional regulator
Pan181_RS19235	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Pan181_RS19240	COG1024	Enoyl-CoA hydratase
Pan181_RS19270	COG1217	gtp-binding protein TYPA
Pan181_RS19275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Pan181_RS19285	COG0484	heat shock protein binding
Pan181_RS19315	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Pan181_RS19325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Pan181_RS19335	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Pan181_RS19350	COG0495	leucyl-tRNA aminoacylation
Pan181_RS19365	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Pan181_RS19390	COG1032	radical SAM domain protein
Pan181_RS19395	COG0527	aspartate kinase activity
Pan181_RS19445	COG2204	response regulator
Pan181_RS19450	COG0205	6-phosphofructokinase activity
Pan181_RS19455	COG0667	Aldo Keto reductase
Pan181_RS19460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Pan181_RS19480	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Pan181_RS19485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Pan181_RS19490	COG1758	RNA polymerase activity
Pan181_RS19495	COG0194	GDP metabolic process
Pan181_RS19500	COG1561	YicC-like family, N-terminal region
Pan181_RS19510	COG0149	triose-phosphate isomerase activity
Pan181_RS19515	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Pan181_RS19525	COG0443	Heat shock 70 kDa protein
Pan181_RS19540	COG0542	response to heat
Pan181_RS19560	COG1012	belongs to the aldehyde dehydrogenase family
Pan181_RS19575	COG1556	Lactate utilization protein
Pan181_RS19580	COG1139	Iron-sulfur cluster binding protein
Pan181_RS19585	COG0247	lactate metabolic process
Pan181_RS19600	COG0493	'glutamate synthase
Pan181_RS19605	COG0069	glutamate synthase activity
Pan181_RS19605	COG0070	glutamate synthase
Pan181_RS19605	COG0067	glutamate synthase
Pan181_RS19610	COG0583	DNA-binding transcription factor activity
Pan181_RS19615	COG3250	beta-galactosidase activity
Pan181_RS19620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Pan181_RS19660	COG1477	protein flavinylation
Pan181_RS19665	COG0673	inositol 2-dehydrogenase activity
Pan181_RS19670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Pan181_RS19695	COG0348	domain, Protein
Pan181_RS19705	COG1034	ATP synthesis coupled electron transport
Pan181_RS19720	COG1032	radical SAM domain protein
Pan181_RS19730	COG0525	valine-tRNA ligase activity
Pan181_RS19745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Pan181_RS19760	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Pan181_RS19765	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Pan181_RS19770	COG1216	Glycosyl transferase, family 2
Pan181_RS19775	COG0523	cobalamin synthesis protein
Pan181_RS19895	COG2770	Histidine kinase
Pan181_RS19895	COG3437	response regulator, receiver
Pan181_RS19915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Pan181_RS19925	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Pan181_RS19930	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Pan181_RS19940	COG0179	Fumarylacetoacetate (FAA) hydrolase
Pan181_RS19960	COG0736	holo-[acyl-carrier-protein] synthase activity
Pan181_RS19965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Pan181_RS19965	COG1754	DNA topoisomerase type I activity
Pan181_RS19985	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Pan181_RS19990	COG0328	RNA-DNA hybrid ribonuclease activity
Pan181_RS20005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Pan181_RS20035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Pan181_RS20040	COG0488	(ABC) transporter
Pan181_RS20055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Pan181_RS20060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Pan181_RS20075	COG1968	undecaprenyl-diphosphatase activity
Pan181_RS20080	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Pan181_RS20080	COG1793	dna ligase
Pan181_RS20110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Pan181_RS20135	COG0204	Acyl-transferase
Pan181_RS20135	COG0318	PFAM AMP-dependent synthetase and ligase
Pan181_RS20140	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Pan181_RS20160	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Pan181_RS20170	COG0288	reversible hydration of carbon dioxide
Pan181_RS20175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Pan181_RS20215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Pan181_RS20225	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Pan181_RS20230	COG2201	protein-glutamate methylesterase activity
Pan181_RS20240	COG0835	chemotaxis
Pan181_RS20245	COG0643	Histidine kinase
Pan181_RS20245	COG0784	Response regulator, receiver
Pan181_RS20245	COG2198	Histidine kinase
Pan181_RS20250	COG0745	RESPONSE REGULATOR receiver
Pan181_RS20260	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_RS20265	COG0702	epimerase
Pan181_RS20270	COG3046	protein related to deoxyribodipyrimidine photolyase
Pan181_RS20315	COG0443	Heat shock 70 kDa protein
Pan181_RS20325	COG0443	Heat shock 70 kDa protein
Pan181_RS20360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Pan181_RS20370	COG1074	ATP-dependent DNA helicase activity
Pan181_RS20385	COG2197	response regulator
Pan181_RS20435	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Pan181_RS20445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Pan181_RS20450	COG0484	heat shock protein binding
Pan181_RS20455	COG0459	protein refolding
Pan181_RS20460	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Pan181_RS20465	COG0459	protein refolding
Pan181_RS20490	COG2165	general secretion pathway protein
Pan181_RS20500	COG0138	bifunctional purine biosynthesis protein purh
Pan181_RS20530	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Pan181_RS20535	COG0386	Belongs to the glutathione peroxidase family
Pan181_RS20545	COG0228	four-way junction DNA binding
Pan181_RS20550	COG0336	Belongs to the RNA methyltransferase TrmD family
Pan181_RS20555	COG0335	large ribosomal subunit rRNA binding
Pan181_RS20565	COG0792	nuclease activity
Pan181_RS20580	COG0504	CTP synthase activity
Pan181_RS20605	COG1487	ribonuclease activity
Pan181_RS20615	COG0322	excinuclease ABC activity
Pan181_RS20635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Pan181_RS20650	COG1595	DNA-templated transcription, initiation
Pan181_RS20670	COG0742	ribosomal rna small subunit methyltransferase
Pan181_RS20675	COG2755	lipolytic protein G-D-S-L family
Pan181_RS20675	COG0657	acetylesterase activity
Pan181_RS20680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Pan181_RS20690	COG0604	alcohol dehydrogenase
Pan181_RS20695	COG2154	pterin-4-alpha-carbinolamine dehydratase
Pan181_RS20700	COG2197	response regulator
Pan181_RS20705	COG1902	pentaerythritol trinitrate reductase activity
Pan181_RS20735	COG1028	Short-chain dehydrogenase reductase Sdr
Pan181_RS20745	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Pan181_RS20745	COG1918	ferrous iron import across plasma membrane
Pan181_RS20755	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Pan181_RS20770	COG4932	domain protein
Pan181_RS20770	COG5492	domain, Protein
Pan181_RS20785	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Pan181_RS20790	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Pan181_RS20795	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Pan181_RS20805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Pan181_RS20850	COG0427	acetyl-CoA hydrolase
Pan181_RS20865	COG0481	GTPase activity
Pan181_RS20875	COG1324	tolerance protein
Pan181_RS20880	COG0438	transferase activity, transferring glycosyl groups
Pan181_RS20895	COG0205	6-phosphofructokinase activity
Pan181_RS20910	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Pan181_RS20920	COG2095	MarC family integral membrane protein
Pan181_RS20925	COG0513	Belongs to the DEAD box helicase family
Pan181_RS20935	COG0724	RNA recognition motif
Pan181_RS20945	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Pan181_RS20960	COG0596	Alpha beta hydrolase
Pan181_RS20985	COG0039	L-malate dehydrogenase activity
Pan181_RS21010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Pan181_RS21030	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Pan181_RS21035	COG0081	regulation of translation
Pan181_RS21040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Pan181_RS21045	COG0222	ribosome binding
Pan181_RS21050	COG0085	RNA polymerase activity
Pan181_RS21055	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Pan181_RS21060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Pan181_RS21065	COG0049	tRNA binding
Pan181_RS21070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Pan181_RS21175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Pan181_RS21180	COG0730	response to heat
Pan181_RS21210	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
Pan181_RS21215	COG0189	ligase activity
Pan181_RS21230	COG2268	Band 7 protein
Pan181_RS21240	COG0673	inositol 2-dehydrogenase activity
Pan181_RS21245	COG0673	inositol 2-dehydrogenase activity
Pan181_RS21260	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Pan181_RS21265	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Pan181_RS21290	COG0191	fructose-bisphosphate aldolase activity
Pan181_RS21330	COG0051	transcription antitermination factor activity, RNA binding
Pan181_RS21335	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Pan181_RS21340	COG0088	Forms part of the polypeptide exit tunnel
Pan181_RS21345	COG0089	rRNA binding
Pan181_RS21350	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Pan181_RS21355	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Pan181_RS21360	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Pan181_RS21365	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Pan181_RS21370	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Pan181_RS21375	COG0255	Belongs to the universal ribosomal protein uL29 family
Pan181_RS21380	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Pan181_RS21385	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Pan181_RS21390	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Pan181_RS21395	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Pan181_RS21400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Pan181_RS21405	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Pan181_RS21410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Pan181_RS21415	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Pan181_RS21420	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Pan181_RS21425	COG0200	Binds to the 23S rRNA
Pan181_RS21430	COG0201	protein transport
Pan181_RS21465	COG0386	Belongs to the glutathione peroxidase family
Pan181_RS21475	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan181_RS21485	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Pan181_RS21490	COG1459	type II secretion system
Pan181_RS21525	COG0318	PFAM AMP-dependent synthetase and ligase
Pan181_RS21535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Pan181_RS21540	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Pan181_RS21555	COG4771	TonB-dependent receptor
Pan181_RS21565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Pan181_RS21600	COG3273	potassium ion transport
Pan181_RS21600	COG0471	metal ion transport
Pan181_RS21610	COG1192	Involved in chromosome partitioning
Pan181_RS21660	COG0673	inositol 2-dehydrogenase activity
Pan181_RS21685	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Pan181_RS21690	COG0135	phosphoribosylanthranilate isomerase activity
Pan181_RS21695	COG3267	Type II secretory pathway component ExeA
Pan181_RS21695	COG3409	Peptidoglycan-binding domain 1 protein
Pan181_RS21705	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Pan181_RS21710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Pan181_RS21725	COG4968	Prepilin-type N-terminal cleavage methylation domain
Pan181_RS21730	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
Pan181_RS21735	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Pan181_RS21760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Pan181_RS21845	COG3250	beta-galactosidase activity
Pan181_RS21850	COG1621	beta-fructofuranosidase activity
Pan181_RS22085	COG3119	arylsulfatase activity
Pan181_RS22095	COG0203	ribosomal protein L17
Pan181_RS22100	COG0202	RNA polymerase activity
Pan181_RS22105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Pan181_RS22110	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Pan181_RS22115	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Pan181_RS22120	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Pan181_RS22130	COG0590	tRNA wobble adenosine to inosine editing
Pan181_RS22140	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Pan181_RS22150	COG0483	inositol monophosphate 1-phosphatase activity
Pan181_RS22185	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Pan181_RS22190	COG0450	alkyl hydroperoxide reductase
Pan181_RS22210	COG1111	helicase
Pan181_RS22210	COG1205	dead DEAH box helicase
Pan181_RS22225	COG3359	exonuclease
Pan181_RS22265	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Pan181_RS22280	COG0443	Heat shock 70 kDa protein
Pan181_RS22295	COG0740	serine-type endopeptidase activity
Pan181_RS22300	COG0740	serine-type endopeptidase activity
Pan181_RS22305	COG0544	peptidyl-prolyl cis-trans isomerase activity
Pan181_RS22340	COG1215	transferase activity, transferring glycosyl groups
Pan181_RS22345	COG0366	Alpha amylase catalytic
Pan181_RS22350	COG0438	transferase activity, transferring glycosyl groups
Pan181_RS22360	COG0438	transferase activity, transferring glycosyl groups
Pan181_RS22375	COG1131	(ABC) transporter
Pan181_RS22390	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Pan181_RS22400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Pan181_RS22420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Pan181_RS22425	COG4166	transmembrane transport
Pan181_RS22430	COG0601	transmembrane transport
Pan181_RS22450	COG1774	PSP1 C-terminal conserved region
Pan181_RS22455	COG0537	adenosine 5'-monophosphoramidase activity
Pan181_RS22520	COG0840	transmembrane signaling receptor activity
Pan181_RS22530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Pan181_RS22545	COG1216	Glycosyl transferase, family 2
Pan181_RS22560	COG2244	polysaccharide biosynthetic process
Pan181_RS22570	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Pan181_RS22575	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Pan181_RS22580	COG2815	serine threonine protein kinase
Pan181_RS22580	COG0515	serine threonine protein kinase
Pan181_RS22585	COG0134	indole-3-glycerol-phosphate synthase activity
Pan181_RS22590	COG0668	transmembrane transport
Pan181_RS22630	COG1054	Belongs to the UPF0176 family
Pan181_RS22635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Pan181_RS22650	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Pan181_RS22660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Pan181_RS22665	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Pan181_RS22670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Pan181_RS22675	COG0110	maltose O-acetyltransferase activity
Pan181_RS22685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Pan181_RS22775	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Pan181_RS22805	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Pan181_RS22845	COG2801	Transposase and inactivated derivatives
Pan181_RS22895	COG2337	Toxic component of a toxin-antitoxin (TA) module
Pan181_RS22925	COG0506	proline dehydrogenase activity
Pan181_RS22925	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Pan181_RS22925	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Pan181_RS22955	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Pan181_RS22965	COG1331	Highly conserved protein containing a thioredoxin domain
Pan181_RS22980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Pan181_RS23010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Pan181_RS23020	COG1454	alcohol dehydrogenase
Pan181_RS23045	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Pan181_RS23060	COG0584	glycerophosphoryl diester phosphodiesterase
Pan181_RS23065	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Pan181_RS23105	COG3119	arylsulfatase activity
Pan181_RS23105	COG3408	Glycogen debranching enzyme
Pan181_RS23110	COG0686	Belongs to the AlaDH PNT family
Pan181_RS23120	COG4956	integral membrane protein (PIN domain superfamily)
Pan181_RS23130	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Pan181_RS23190	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
Pan181_RS23195	COG3119	arylsulfatase activity
Pan181_RS23195	COG3408	Glycogen debranching enzyme
Pan181_RS23200	COG1301	dicarboxylic acid transport
Pan181_RS23220	COG3123	guanosine phosphorylase activity
Pan181_RS23235	COG0574	Belongs to the PEP-utilizing enzyme family
Pan181_RS23235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Pan181_RS23245	COG4771	TonB-dependent receptor
Pan181_RS23290	COG2204	response regulator
Pan181_RS23315	COG2020	methyltransferase activity
Pan181_RS23340	COG0440	acetolactate synthase activity
Pan181_RS23345	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Pan181_RS23350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Pan181_RS23355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Pan181_RS23360	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Pan181_RS23365	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Pan181_RS23390	COG0482	sulfurtransferase activity
Pan181_RS23395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Pan181_RS23455	COG0436	Aminotransferase
Pan181_RS23465	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Pan181_RS23470	COG1776	CheC inhibitor of MCP methylation
Pan181_RS23470	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Pan181_RS23495	COG0006	proline dipeptidase activity
Pan181_RS23500	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Pan181_RS23500	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Pan181_RS23510	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Pan181_RS23510	COG0674	pyruvate-flavodoxin oxidoreductase activity
Pan181_RS23515	COG1013	pyruvate-flavodoxin oxidoreductase activity
Pan181_RS23525	COG0535	radical SAM domain protein
Pan181_RS23545	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Pan181_RS23595	COG3119	arylsulfatase activity
Pan181_RS23610	COG3119	arylsulfatase activity
Pan181_RS23690	COG2207	Transcriptional regulator
Pan181_RS23690	COG1609	Transcriptional regulator
Pan181_RS23695	COG0697	spore germination
Pan181_RS23700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Pan181_RS23700	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Pan181_RS23720	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Pan181_RS23725	COG1216	Glycosyl transferase, family 2
Pan181_RS23745	COG4974	Belongs to the 'phage' integrase family
Pan181_RS23750	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Pan181_RS23785	COG3335	DDE superfamily endonuclease
Pan181_RS23790	COG1446	asparaginase
Pan181_RS23795	COG0446	pyridine nucleotide-disulphide oxidoreductase
Pan181_RS23800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Pan181_RS23825	COG0840	transmembrane signaling receptor activity
Pan181_RS23830	COG2309	aminopeptidase activity
Pan181_RS23835	COG1960	acyl-CoA dehydrogenase activity
Pan181_RS23840	COG1137	ATPase activity
Pan181_RS23845	COG0681	Belongs to the peptidase S26 family
Pan181_RS23855	COG0438	transferase activity, transferring glycosyl groups
Pan181_RS23870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_RS23875	COG3437	response regulator, receiver
Pan181_RS23895	COG0017	Asparaginyl-tRNA synthetase
Pan181_RS23905	COG1966	Carbon starvation protein
Pan181_RS23910	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Pan181_RS23915	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Pan181_RS23920	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Pan181_RS23930	COG4303	Ethanolamine ammonia lyase large subunit
Pan181_RS23950	COG0183	Belongs to the thiolase family
Pan181_RS23985	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Pan181_RS23995	COG0505	Belongs to the CarA family
Pan181_RS24000	COG0436	Aminotransferase
Pan181_RS24050	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Pan181_RS24060	COG0517	IMP dehydrogenase activity
Pan181_RS24060	COG0617	tRNA 3'-terminal CCA addition
Pan181_RS24060	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Pan181_RS24105	COG3604	Transcriptional regulator
Pan181_RS24245	COG0515	serine threonine protein kinase
Pan181_RS24245	COG2815	serine threonine protein kinase
Pan181_RS24330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Pan181_RS24335	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Pan181_RS24360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Pan181_RS24365	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Pan181_RS24370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Pan181_RS24400	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Pan181_RS24430	COG1119	ATPase activity
Pan181_RS24435	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Pan181_RS24450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Pan181_RS24490	COG0577	efflux transmembrane transporter activity
Pan181_RS24490	COG1136	(ABC) transporter
Pan181_RS24500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Pan181_RS24550	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Pan181_RS24565	COG0822	iron-sulfur transferase activity
Pan181_RS24590	COG0515	serine threonine protein kinase
Pan181_RS24590	COG2815	serine threonine protein kinase
Pan181_RS24595	COG1272	protein, Hemolysin III
Pan181_RS24610	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Pan181_RS24735	COG3250	beta-galactosidase activity
Pan181_RS24755	COG3537	Alpha-1,2-mannosidase
Pan181_RS24810	COG0659	secondary active sulfate transmembrane transporter activity
Pan181_RS24830	COG1733	regulation of RNA biosynthetic process
Pan181_RS24855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Pan181_RS24860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Pan181_RS24865	COG1120	ATPase activity
Pan181_RS24870	COG2226	methyltransferase
Pan181_RS24885	COG3119	arylsulfatase activity
Pan181_RS24890	COG0288	reversible hydration of carbon dioxide
Pan181_RS24905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Pan181_RS24910	COG2088	sporulation resulting in formation of a cellular spore
Pan181_RS24920	COG0114	fumarate hydratase activity
Pan181_RS24930	COG0288	reversible hydration of carbon dioxide
Pan181_RS24935	COG0793	Belongs to the peptidase S41A family
Pan181_RS24955	COG3386	PFAM SMP-30 Gluconolaconase
Pan181_RS24960	COG2084	Dehydrogenase
Pan181_RS24970	COG1760	l-serine dehydratase
Pan181_RS24990	COG0463	Glycosyl transferase, family 2
Pan181_RS25025	COG0714	Associated with various cellular activities
Pan181_RS25070	COG0438	transferase activity, transferring glycosyl groups
Pan181_RS25080	COG0628	permease
Pan181_RS25085	COG1940	carbohydrate kinase activity
Pan181_RS25135	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Pan181_RS25150	COG0189	ligase activity
Pan181_RS25150	COG4067	protein conserved in archaea
Pan181_RS25155	COG0569	domain protein
Pan181_RS25155	COG0189	ligase activity
Pan181_RS25215	COG1136	(ABC) transporter
Pan181_RS25215	COG0577	efflux transmembrane transporter activity
Pan181_RS25220	COG1136	(ABC) transporter
Pan181_RS25230	COG1063	alcohol dehydrogenase
Pan181_RS25235	COG0156	8-amino-7-oxononanoate synthase activity
Pan181_RS25270	COG1595	DNA-templated transcription, initiation
Pan181_RS25280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Pan181_RS25300	COG3119	arylsulfatase activity
Pan181_RS25315	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Pan181_RS25325	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Pan181_RS25335	COG1132	(ABC) transporter
Pan181_RS25370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Pan181_RS25400	COG0072	phenylalanine-tRNA ligase activity
Pan181_RS25405	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Pan181_RS25410	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Pan181_RS25415	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Pan181_RS25425	COG4864	UPF0365 protein
Pan181_RS25450	COG1136	(ABC) transporter
Pan181_RS25485	COG1030	water channel activity
Pan181_RS25490	COG1192	Involved in chromosome partitioning
Pan181_RS25505	COG1595	DNA-templated transcription, initiation
Pan181_RS25585	COG1834	amidinotransferase
Pan181_RS25610	COG1216	Glycosyl transferase, family 2
Pan181_RS25620	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Pan181_RS25630	COG1301	dicarboxylic acid transport
Pan181_RS25640	COG1940	carbohydrate kinase activity
Pan181_RS25650	COG0517	IMP dehydrogenase activity
Pan181_RS25650	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Pan181_RS25675	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Pan181_RS25710	COG1283	sodium-dependent phosphate transmembrane transporter activity
Pan181_RS25715	COG0673	inositol 2-dehydrogenase activity
Pan181_RS25750	COG3534	alpha-L-arabinofuranosidase
Pan181_RS25755	COG0673	inositol 2-dehydrogenase activity
Pan181_RS25765	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Pan181_RS25780	COG0483	inositol monophosphate 1-phosphatase activity
Pan181_RS25800	COG1160	GTP binding
Pan181_RS25805	COG1573	uracil-dna glycosylase
Pan181_RS25810	COG0531	amino acid
Pan181_RS25825	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Pan181_RS25835	COG1104	cysteine desulfurase activity
Pan181_RS25900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Pan181_RS25910	COG3706	GGDEF domain
Pan181_RS25970	COG0840	transmembrane signaling receptor activity
Pan181_RS26050	COG2755	lipolytic protein G-D-S-L family
Pan181_RS26130	COG3852	Histidine kinase
Pan181_RS26155	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Pan181_RS26215	COG3876	Protein conserved in bacteria
Pan181_RS26250	COG0517	IMP dehydrogenase activity
Pan181_RS26250	COG0516	GMP reductase activity
Pan181_RS26285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Pan181_RS26290	COG0071	Belongs to the small heat shock protein (HSP20) family
Pan181_RS26315	COG0811	peptide transport
Pan181_RS26375	COG1285	pathogenesis