locus-tag	class	description
AP3564_RS00185	COG0606	chelatase, subunit chli
AP3564_RS00205	COG4720	Psort location CytoplasmicMembrane, score
AP3564_RS00220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AP3564_RS00230	COG2153	protein acetylation
AP3564_RS00250	COG0438	transferase activity, transferring glycosyl groups
AP3564_RS00255	COG2144	transferase activity, transferring acyl groups
AP3564_RS00265	COG0431	NADPH-dependent FMN reductase
AP3564_RS00310	COG0411	ABC transporter
AP3564_RS00325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AP3564_RS00330	COG2030	dehydratase
AP3564_RS00335	COG0318	PFAM AMP-dependent synthetase and ligase
AP3564_RS00360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AP3564_RS00370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AP3564_RS00375	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_RS00395	COG0508	dehydrogenase complex catalyzes the overall conversion of
AP3564_RS00400	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AP3564_RS00405	COG1595	DNA-templated transcription, initiation
AP3564_RS00415	COG1131	(ABC) transporter
AP3564_RS00465	COG0745	RESPONSE REGULATOR receiver
AP3564_RS00470	COG5002	protein histidine kinase activity
AP3564_RS00485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP3564_RS00485	COG3711	transcriptional antiterminator
AP3564_RS00495	COG3730	PTS system glucitol sorbitol-specific
AP3564_RS00500	COG3732	PTS system glucitol sorbitol-specific
AP3564_RS00510	COG0386	Belongs to the glutathione peroxidase family
AP3564_RS00515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AP3564_RS00520	COG2356	endonuclease I
AP3564_RS00540	COG2213	PTS system mannitol-specific
AP3564_RS00540	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP3564_RS00545	COG3414	Phosphotransferase system galactitol-specific IIB component
AP3564_RS00550	COG3775	system Galactitol-specific IIC component
AP3564_RS00555	COG1063	alcohol dehydrogenase
AP3564_RS00565	COG1063	alcohol dehydrogenase
AP3564_RS00585	COG0477	Major facilitator Superfamily
AP3564_RS00600	COG0583	DNA-binding transcription factor activity
AP3564_RS00615	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_RS00625	COG0196	riboflavin kinase activity
AP3564_RS00630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AP3564_RS00635	COG0179	Fumarylacetoacetate (FAA) hydrolase
AP3564_RS00650	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_RS00660	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_RS00680	COG0559	Belongs to the binding-protein-dependent transport system permease family
AP3564_RS00695	COG0410	ABC transporter
AP3564_RS00745	COG0714	Associated with various cellular activities
AP3564_RS00750	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AP3564_RS00755	COG1305	Transglutaminase-like
AP3564_RS00760	COG0519	Catalyzes the synthesis of GMP from XMP
AP3564_RS00760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AP3564_RS00765	COG2252	PERMEase
AP3564_RS00770	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AP3564_RS00775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AP3564_RS00780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AP3564_RS00785	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AP3564_RS00790	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AP3564_RS00795	COG0047	phosphoribosylformylglycinamidine synthase activity
AP3564_RS00800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AP3564_RS00805	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AP3564_RS00810	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AP3564_RS00815	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AP3564_RS00820	COG0138	bifunctional purine biosynthesis protein purh
AP3564_RS00835	COG0151	Belongs to the GarS family
AP3564_RS00840	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AP3564_RS00845	COG1470	cell adhesion involved in biofilm formation
AP3564_RS00850	COG4496	protein, YerC YecD
AP3564_RS00855	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AP3564_RS00860	COG0210	DNA helicase
AP3564_RS00865	COG0210	DNA helicase
AP3564_RS00870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AP3564_RS00875	COG4851	CamS sex pheromone cAM373 precursor
AP3564_RS00895	COG0154	amidase activity
AP3564_RS00905	COG1597	lipid kinase activity
AP3564_RS00915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AP3564_RS00945	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AP3564_RS00975	COG4372	Transposase
AP3564_RS00995	COG1201	RNA secondary structure unwinding
AP3564_RS01005	COG1192	Involved in chromosome partitioning
AP3564_RS01030	COG1192	Involved in chromosome partitioning
AP3564_RS01085	COG2031	fatty acid transporter
AP3564_RS01090	COG0583	DNA-binding transcription factor activity
AP3564_RS01095	COG0477	Major facilitator Superfamily
AP3564_RS01110	COG1309	transcriptional regulator
AP3564_RS01115	COG1131	(ABC) transporter
AP3564_RS01150	COG0579	oxidoreductase
AP3564_RS01155	COG2329	Antibiotic biosynthesis monooxygenase
AP3564_RS01160	COG0686	Belongs to the AlaDH PNT family
AP3564_RS01165	COG2508	Transcriptional regulator
AP3564_RS01165	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AP3564_RS01170	COG1126	abc transporter atp-binding protein
AP3564_RS01175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AP3564_RS01200	COG1126	abc transporter atp-binding protein
AP3564_RS01205	COG0765	amino acid transport
AP3564_RS01210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AP3564_RS01220	COG1309	transcriptional regulator
AP3564_RS01255	COG1518	maintenance of DNA repeat elements
AP3564_RS01260	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AP3564_RS01265	COG0840	transmembrane signaling receptor activity
AP3564_RS01275	COG0582	viral genome integration into host DNA
AP3564_RS01280	COG0490	domain, Protein
AP3564_RS01285	COG0475	glutathione-regulated potassium exporter activity
AP3564_RS01290	COG1473	amidohydrolase
AP3564_RS01295	COG0183	Belongs to the thiolase family
AP3564_RS01300	COG2814	Major facilitator Superfamily
AP3564_RS01305	COG1309	transcriptional regulator
AP3564_RS01310	COG2966	Psort location CytoplasmicMembrane, score
AP3564_RS01330	COG1609	Transcriptional regulator
AP3564_RS01335	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AP3564_RS01350	COG3842	ATPase activity
AP3564_RS01355	COG1176	ABC-type spermidine putrescine transport system, permease component I
AP3564_RS01360	COG1177	transmembrane transport
AP3564_RS01365	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AP3564_RS01375	COG2814	Major facilitator Superfamily
AP3564_RS01380	COG0753	catalase activity
AP3564_RS01385	COG1132	(ABC) transporter
AP3564_RS01395	COG0561	phosphatase activity
AP3564_RS01400	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AP3564_RS01405	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AP3564_RS01410	COG4605	iron ion homeostasis
AP3564_RS01415	COG4604	ABC transporter, ATP-binding protein
AP3564_RS01420	COG4607	ABC-type enterochelin transport system periplasmic component
AP3564_RS01445	COG1587	Uroporphyrinogen-III synthase
AP3564_RS01460	COG3842	ATPase activity
AP3564_RS01465	COG0395	ABC-type sugar transport system, permease component
AP3564_RS01470	COG1175	transmembrane transport
AP3564_RS01475	COG1653	transport
AP3564_RS01480	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AP3564_RS01485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AP3564_RS01500	COG1733	regulation of RNA biosynthetic process
AP3564_RS01515	COG1960	acyl-CoA dehydrogenase activity
AP3564_RS01525	COG2801	Transposase and inactivated derivatives
AP3564_RS01545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AP3564_RS01555	COG4948	Mandelate Racemase Muconate Lactonizing
AP3564_RS01565	COG2311	Membrane
AP3564_RS01585	COG4840	Belongs to the UPF0435 family
AP3564_RS01590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AP3564_RS01595	COG4980	gas vesicle protein
AP3564_RS01600	COG1295	ribonuclease BN
AP3564_RS01620	COG1511	domain protein
AP3564_RS01625	COG1309	transcriptional regulator
AP3564_RS01645	COG0387	Pfam Sodium calcium exchanger
AP3564_RS01655	COG0535	radical SAM domain protein
AP3564_RS01680	COG1850	ribulose-bisphosphate carboxylase activity
AP3564_RS01685	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
AP3564_RS01690	COG0235	Class ii aldolase
AP3564_RS01695	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AP3564_RS01705	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AP3564_RS01710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AP3564_RS01715	COG0436	Aminotransferase
AP3564_RS01730	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AP3564_RS01735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AP3564_RS01745	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AP3564_RS01850	COG4499	WXG100 protein secretion system (Wss), protein YukC
AP3564_RS01960	COG2190	(PTS) system
AP3564_RS01965	COG1737	Transcriptional regulator
AP3564_RS01970	COG1486	melibiose metabolic process
AP3564_RS01975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AP3564_RS01975	COG1263	PTS System
AP3564_RS02070	COG2721	sulfolactate sulfo-lyase activity
AP3564_RS02105	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_RS02115	COG1309	transcriptional regulator
AP3564_RS02120	COG1694	Mazg nucleotide pyrophosphohydrolase
AP3564_RS02140	COG1116	anion transmembrane transporter activity
AP3564_RS02145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AP3564_RS02150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AP3564_RS02180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AP3564_RS02185	COG1063	alcohol dehydrogenase
AP3564_RS02190	COG0235	Class ii aldolase
AP3564_RS02215	COG1742	UPF0060 membrane protein
AP3564_RS02220	COG0501	Belongs to the peptidase M48B family
AP3564_RS02225	COG2814	Major facilitator Superfamily
AP3564_RS02245	COG0789	Transcriptional regulator
AP3564_RS02260	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AP3564_RS02280	COG0626	cystathionine gamma-synthase activity
AP3564_RS02285	COG2329	Antibiotic biosynthesis monooxygenase
AP3564_RS02290	COG0385	Bile acid
AP3564_RS02305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AP3564_RS02325	COG0583	DNA-binding transcription factor activity
AP3564_RS02330	COG2814	Major facilitator Superfamily
AP3564_RS02335	COG2066	Belongs to the glutaminase family
AP3564_RS02345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AP3564_RS02350	COG2271	Major facilitator Superfamily
AP3564_RS02355	COG0028	Belongs to the TPP enzyme family
AP3564_RS02360	COG0583	DNA-binding transcription factor activity
AP3564_RS02365	COG0861	Integral membrane protein TerC family
AP3564_RS02395	COG2137	regulation of response to DNA damage stimulus
AP3564_RS02415	COG1988	membrane-bound metal-dependent
AP3564_RS02420	COG1194	a g-specific adenine glycosylase
AP3564_RS02430	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_RS02440	COG1968	undecaprenyl-diphosphatase activity
AP3564_RS02450	COG3557	Belongs to the UPF0374 family
AP3564_RS02455	COG1132	(ABC) transporter
AP3564_RS02465	COG4129	membrane
AP3564_RS02470	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AP3564_RS02475	COG4555	ABC transporter
AP3564_RS02495	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AP3564_RS02500	COG0735	belongs to the Fur family
AP3564_RS02605	COG4974	Belongs to the 'phage' integrase family
AP3564_RS02630	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AP3564_RS02635	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AP3564_RS02640	COG3290	protein histidine kinase activity
AP3564_RS02640	COG3829	transcription factor binding
AP3564_RS02645	COG2376	Dihydroxyacetone kinase
AP3564_RS02660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP3564_RS02670	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AP3564_RS02675	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AP3564_RS02700	COG1959	2 iron, 2 sulfur cluster binding
AP3564_RS02705	COG0482	sulfurtransferase activity
AP3564_RS02710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AP3564_RS02715	COG0702	epimerase
AP3564_RS02735	COG2837	iron assimilation
AP3564_RS02740	COG2822	iron ion transport
AP3564_RS02745	COG3284	Transcriptional regulator
AP3564_RS02750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AP3564_RS02755	COG0022	dehydrogenase e1 component
AP3564_RS02760	COG0508	dehydrogenase complex catalyzes the overall conversion of
AP3564_RS02780	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_RS02795	COG1063	alcohol dehydrogenase
AP3564_RS02800	COG2814	Major facilitator Superfamily
AP3564_RS02815	COG0431	NADPH-dependent FMN reductase
AP3564_RS02820	COG2226	methyltransferase
AP3564_RS02850	COG3382	B3 4 domain protein
AP3564_RS02875	COG2766	serine protein kinase
AP3564_RS02880	COG2718	Belongs to the UPF0229 family
AP3564_RS02895	COG1268	BioY protein
AP3564_RS02900	COG0318	PFAM AMP-dependent synthetase and ligase
AP3564_RS02905	COG0183	Belongs to the thiolase family
AP3564_RS02910	COG0586	Pfam SNARE associated Golgi protein
AP3564_RS02920	COG2249	NAD(P)H dehydrogenase (quinone) activity
AP3564_RS02925	COG0656	L-ascorbic acid biosynthetic process
AP3564_RS02940	COG0517	IMP dehydrogenase activity
AP3564_RS02945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AP3564_RS02955	COG1959	2 iron, 2 sulfur cluster binding
AP3564_RS02965	COG2719	SpoVR family
AP3564_RS02970	COG0861	Integral membrane protein TerC family
AP3564_RS02985	COG0628	permease
AP3564_RS02990	COG0628	permease
AP3564_RS03005	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AP3564_RS03015	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AP3564_RS03020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AP3564_RS03045	COG0411	ABC transporter
AP3564_RS03060	COG0840	transmembrane signaling receptor activity
AP3564_RS03085	COG0189	ligase activity
AP3564_RS03090	COG0189	ligase activity
AP3564_RS03095	COG0189	ligase activity
AP3564_RS03105	COG4399	Belongs to the UPF0754 family
AP3564_RS03110	COG0697	spore germination
AP3564_RS03130	COG3679	Belongs to the UPF0342 family
AP3564_RS03135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AP3564_RS03140	COG1940	carbohydrate kinase activity
AP3564_RS03145	COG0561	phosphatase activity
AP3564_RS03150	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AP3564_RS03165	COG0420	3'-5' exonuclease activity
AP3564_RS03170	COG4717	serine-type aminopeptidase activity
AP3564_RS03175	COG3481	metal-dependent phosphohydrolase, HD sub domain
AP3564_RS03185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AP3564_RS03205	COG1846	Transcriptional regulator
AP3564_RS03210	COG4980	gas vesicle protein
AP3564_RS03225	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AP3564_RS03230	COG0537	adenosine 5'-monophosphoramidase activity
AP3564_RS03235	COG4473	ABC transporter
AP3564_RS03240	COG1131	(ABC) transporter
AP3564_RS03245	COG2329	Antibiotic biosynthesis monooxygenase
AP3564_RS03250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AP3564_RS03255	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AP3564_RS03260	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AP3564_RS03265	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AP3564_RS03270	COG1609	Transcriptional regulator
AP3564_RS03280	COG1234	tRNA 3'-trailer cleavage
AP3564_RS03290	COG4120	Belongs to the binding-protein-dependent transport system permease family
AP3564_RS03295	COG1116	anion transmembrane transporter activity
AP3564_RS03295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AP3564_RS03300	COG1396	sequence-specific DNA binding
AP3564_RS03305	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AP3564_RS03315	COG0501	Belongs to the peptidase M48B family
AP3564_RS03320	COG1674	ftsk spoiiie
AP3564_RS03325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AP3564_RS03330	COG2309	aminopeptidase activity
AP3564_RS03335	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
AP3564_RS03350	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AP3564_RS03350	COG1605	Chorismate mutase
AP3564_RS03355	COG1609	Transcriptional regulator
AP3564_RS03360	COG0123	including yeast histone deacetylase and acetoin utilization protein
AP3564_RS03365	COG0517	IMP dehydrogenase activity
AP3564_RS03370	COG0454	-acetyltransferase
AP3564_RS03375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AP3564_RS03380	COG0456	acetyltransferase
AP3564_RS03395	COG3209	COG3209 Rhs family protein
AP3564_RS03435	COG3209	COG3209 Rhs family protein
AP3564_RS03620	COG1737	Transcriptional regulator
AP3564_RS03630	COG1063	alcohol dehydrogenase
AP3564_RS03635	COG1830	Aldolase
AP3564_RS03660	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AP3564_RS03665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AP3564_RS03680	COG0646	methionine synthase
AP3564_RS03680	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AP3564_RS03705	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AP3564_RS03710	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AP3564_RS03710	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AP3564_RS03715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AP3564_RS03725	COG1063	alcohol dehydrogenase
AP3564_RS03730	COG1830	Aldolase
AP3564_RS03745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AP3564_RS03755	COG1091	dTDP-4-dehydrorhamnose reductase activity
AP3564_RS03780	COG0463	Glycosyl transferase, family 2
AP3564_RS03780	COG1216	Glycosyl transferase, family 2
AP3564_RS03820	COG1064	alcohol dehydrogenase
AP3564_RS03835	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AP3564_RS03840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AP3564_RS03845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AP3564_RS03850	COG4464	protein tyrosine phosphatase activity
AP3564_RS03855	COG0489	protein tyrosine kinase activity
AP3564_RS03860	COG3944	biosynthesis protein
AP3564_RS03865	COG4715	Zinc finger, swim domain protein
AP3564_RS03870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AP3564_RS03875	COG0629	single-stranded DNA binding
AP3564_RS03885	COG1476	TRANSCRIPTIONal
AP3564_RS03910	COG4786	Flagellar basal body rod
AP3564_RS03915	COG4786	Flagellar basal body rod
AP3564_RS03925	COG1077	Cell shape determining protein MreB Mrl
AP3564_RS03930	COG1609	Transcriptional regulator
AP3564_RS03940	COG1984	allophanate hydrolase subunit 2
AP3564_RS03945	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AP3564_RS03950	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AP3564_RS03955	COG1247	-acetyltransferase
AP3564_RS03960	COG0739	heme binding
AP3564_RS03970	COG2385	sporulation resulting in formation of a cellular spore
AP3564_RS03975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AP3564_RS03985	COG4836	Membrane
AP3564_RS03990	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AP3564_RS03995	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AP3564_RS04000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AP3564_RS04005	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AP3564_RS04010	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AP3564_RS04015	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AP3564_RS04020	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AP3564_RS04025	COG0356	it plays a direct role in the translocation of protons across the membrane
AP3564_RS04040	COG1404	Belongs to the peptidase S8 family
AP3564_RS04050	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AP3564_RS04055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AP3564_RS04065	COG0698	ribose 5-phosphate isomerase
AP3564_RS04070	COG0840	transmembrane signaling receptor activity
AP3564_RS04075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AP3564_RS04080	COG1971	Probably functions as a manganese efflux pump
AP3564_RS04085	COG0009	L-threonylcarbamoyladenylate synthase
AP3564_RS04100	COG2890	protein-(glutamine-N5) methyltransferase activity
AP3564_RS04105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AP3564_RS04110	COG0789	Transcriptional regulator
AP3564_RS04120	COG1435	thymidine kinase activity
AP3564_RS04125	COG0254	rRNA binding
AP3564_RS04130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AP3564_RS04135	COG1494	fructose-1,6-bisphosphatase
AP3564_RS04140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AP3564_RS04145	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AP3564_RS04150	COG0191	fructose-bisphosphate aldolase activity
AP3564_RS04155	COG2204	response regulator
AP3564_RS04160	COG4821	SIS domain
AP3564_RS04165	COG0504	CTP synthase activity
AP3564_RS04170	COG3343	RNA polymerase activity
AP3564_RS04175	COG2181	nitrate reductase activity
AP3564_RS04175	COG0247	lactate metabolic process
AP3564_RS04180	COG1595	DNA-templated transcription, initiation
AP3564_RS04185	COG0018	arginyl-trna synthetase
AP3564_RS04190	COG4506	Protein conserved in bacteria
AP3564_RS04195	COG0010	Belongs to the arginase family
AP3564_RS04200	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AP3564_RS04205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AP3564_RS04225	COG4844	belongs to the
AP3564_RS04230	COG1078	dGTPase activity
AP3564_RS04235	COG3465	dGTPase activity
AP3564_RS04240	COG1994	Peptidase M50
AP3564_RS04250	COG0280	phosphate acetyltransferase
AP3564_RS04255	COG3253	May function as heme-dependent peroxidase
AP3564_RS04260	COG3773	Cell wall hydrolase
AP3564_RS04275	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AP3564_RS04280	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AP3564_RS04285	COG2363	Small membrane protein
AP3564_RS04295	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AP3564_RS04330	COG1309	transcriptional regulator
AP3564_RS04335	COG0351	phosphomethylpyrimidine kinase
AP3564_RS04340	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AP3564_RS04345	COG0584	glycerophosphoryl diester phosphodiesterase
AP3564_RS04355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AP3564_RS04360	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AP3564_RS04380	COG0778	Nitroreductase
AP3564_RS04385	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AP3564_RS04395	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AP3564_RS04405	COG0765	amino acid transport
AP3564_RS04420	COG0561	phosphatase activity
AP3564_RS04425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AP3564_RS04445	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AP3564_RS04455	COG0410	ABC transporter
AP3564_RS04475	COG0683	leucine binding
AP3564_RS04480	COG1082	Xylose isomerase domain protein TIM barrel
AP3564_RS04485	COG3764	Sortase (surface protein transpeptidase)
AP3564_RS04495	COG0022	dehydrogenase e1 component
AP3564_RS04500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AP3564_RS04545	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AP3564_RS04550	COG0737	Belongs to the 5'-nucleotidase family
AP3564_RS04570	COG0456	acetyltransferase
AP3564_RS04575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AP3564_RS04575	COG3153	acetyltransferase
AP3564_RS04580	COG0745	RESPONSE REGULATOR receiver
AP3564_RS04585	COG2205	protein histidine kinase activity
AP3564_RS04590	COG1136	(ABC) transporter
AP3564_RS04595	COG0577	efflux transmembrane transporter activity
AP3564_RS04600	COG2910	NAD(P)H-binding
AP3564_RS04605	COG1959	2 iron, 2 sulfur cluster binding
AP3564_RS04610	COG0784	Response regulator, receiver
AP3564_RS04615	COG4191	Histidine kinase
AP3564_RS04635	COG1131	(ABC) transporter
AP3564_RS04640	COG2072	flavoprotein involved in K transport
AP3564_RS04655	COG1607	acyl-coa hydrolase
AP3564_RS04660	COG0492	ferredoxin-NADP+ reductase activity
AP3564_RS04665	COG0583	DNA-binding transcription factor activity
AP3564_RS04690	COG3973	AAA domain
AP3564_RS04705	COG5002	protein histidine kinase activity
AP3564_RS04725	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AP3564_RS04730	COG0732	type I restriction modification DNA specificity domain
AP3564_RS04735	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AP3564_RS04750	COG1349	DNA-binding transcription factor activity
AP3564_RS04760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AP3564_RS04760	COG0446	pyridine nucleotide-disulphide oxidoreductase
AP3564_RS04775	COG3192	ethanolamine utilization protein
AP3564_RS04785	COG1349	DNA-binding transcription factor activity
AP3564_RS04815	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AP3564_RS04825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AP3564_RS04830	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AP3564_RS04835	COG4853	Protein conserved in bacteria
AP3564_RS04845	COG5002	protein histidine kinase activity
AP3564_RS04850	COG0745	RESPONSE REGULATOR receiver
AP3564_RS04865	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AP3564_RS04870	COG0305	Participates in initiation and elongation during chromosome replication
AP3564_RS04875	COG0359	binds to the 23S rRNA
AP3564_RS04880	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AP3564_RS04885	COG4241	membrane
AP3564_RS04890	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AP3564_RS04895	COG0629	single-stranded DNA binding
AP3564_RS04900	COG0360	Binds together with S18 to 16S ribosomal RNA
AP3564_RS04905	COG0012	GTP binding
AP3564_RS04910	COG4481	Protein conserved in bacteria
AP3564_RS04920	COG1475	DNA binding
AP3564_RS04925	COG1192	Involved in chromosome partitioning
AP3564_RS04935	COG1475	DNA binding
AP3564_RS04940	COG0357	Ribosomal RNA small subunit methyltransferase G
AP3564_RS04945	COG0445	tRNA wobble uridine modification
AP3564_RS04950	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AP3564_RS04955	COG1847	R3H domain protein
AP3564_RS04960	COG0706	membrane insertase activity
AP3564_RS04965	COG0594	ribonuclease P activity
AP3564_RS04970	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AP3564_RS04980	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AP3564_RS04985	COG0592	DNA-directed DNA polymerase activity
AP3564_RS04990	COG2501	S4 domain
AP3564_RS04995	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AP3564_RS05000	COG0187	DNA topoisomerase II activity
AP3564_RS05005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AP3564_RS05045	COG0516	GMP reductase activity
AP3564_RS05045	COG0517	IMP dehydrogenase activity
AP3564_RS05060	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AP3564_RS05065	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AP3564_RS05070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AP3564_RS05080	COG0579	oxidoreductase
AP3564_RS05100	COG1388	LysM domain
AP3564_RS05100	COG3858	chitin binding
AP3564_RS05105	COG0590	tRNA wobble adenosine to inosine editing
AP3564_RS05115	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AP3564_RS05120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AP3564_RS05160	COG1982	Orn Lys Arg decarboxylase major
AP3564_RS05165	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AP3564_RS05170	COG3870	Protein conserved in bacteria
AP3564_RS05175	COG1728	Protein conserved in bacteria
AP3564_RS05180	COG0470	DNA polymerase III
AP3564_RS05185	COG1774	PSP1 C-terminal conserved region
AP3564_RS05190	COG4467	Involved in initiation control of chromosome replication
AP3564_RS05195	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AP3564_RS05200	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AP3564_RS05205	COG2002	toxin-antitoxin pair type II binding
AP3564_RS05215	COG0084	hydrolase, TatD family'
AP3564_RS05220	COG3583	domain protein
AP3564_RS05220	COG3584	3D domain protein
AP3564_RS05225	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AP3564_RS05230	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AP3564_RS05240	COG4466	Protein conserved in bacteria
AP3564_RS05250	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AP3564_RS05255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AP3564_RS05260	COG0251	oxidation-reduction process
AP3564_RS05265	COG2088	sporulation resulting in formation of a cellular spore
AP3564_RS05270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AP3564_RS05275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AP3564_RS05280	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AP3564_RS05285	COG0193	aminoacyl-tRNA hydrolase activity
AP3564_RS05295	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AP3564_RS05300	COG2002	toxin-antitoxin pair type II binding
AP3564_RS05335	COG2244	polysaccharide biosynthetic process
AP3564_RS05340	COG3956	TIGRFAM MazG family protein
AP3564_RS05345	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AP3564_RS05360	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AP3564_RS05365	COG1098	S1 RNA binding domain
AP3564_RS05380	COG2208	phosphoserine phosphatase activity
AP3564_RS05385	COG2304	oxidoreductase activity
AP3564_RS05390	COG0515	serine threonine protein kinase
AP3564_RS05395	COG0037	tRNA processing
AP3564_RS05400	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AP3564_RS05405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AP3564_RS05410	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AP3564_RS05415	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AP3564_RS05420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AP3564_RS05425	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AP3564_RS05430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AP3564_RS05435	COG0512	Glutamine amidotransferase of anthranilate synthase
AP3564_RS05440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AP3564_RS05445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AP3564_RS05450	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AP3564_RS05455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AP3564_RS05460	COG1396	sequence-specific DNA binding
AP3564_RS05465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AP3564_RS05470	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AP3564_RS05575	COG1131	(ABC) transporter
AP3564_RS05595	COG4372	Transposase
AP3564_RS05630	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AP3564_RS05655	COG1459	type II secretion system
AP3564_RS05665	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AP3564_RS05690	COG1285	pathogenesis
AP3564_RS05700	COG3880	PFAM UvrB UvrC protein
AP3564_RS05705	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AP3564_RS05710	COG0542	response to heat
AP3564_RS05715	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AP3564_RS05720	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AP3564_RS05725	COG4956	integral membrane protein (PIN domain superfamily)
AP3564_RS05730	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AP3564_RS05735	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AP3564_RS05740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AP3564_RS05745	COG1045	serine acetyltransferase
AP3564_RS05750	COG0215	cysteine-tRNA ligase activity
AP3564_RS05755	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AP3564_RS05760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AP3564_RS05765	COG3688	RNA-binding protein containing a PIN domain
AP3564_RS05775	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AP3564_RS05780	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AP3564_RS05785	COG0250	Participates in transcription elongation, termination and antitermination
AP3564_RS05790	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AP3564_RS05795	COG0081	regulation of translation
AP3564_RS05800	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AP3564_RS05805	COG0222	ribosome binding
AP3564_RS05810	COG2813	Specifically methylates the guanine in position
AP3564_RS05815	COG0085	RNA polymerase activity
AP3564_RS05820	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AP3564_RS05825	COG1358	cellular component organization or biogenesis
AP3564_RS05830	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AP3564_RS05835	COG0049	tRNA binding
AP3564_RS05840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AP3564_RS05845	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AP3564_RS05850	COG0051	transcription antitermination factor activity, RNA binding
AP3564_RS05855	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AP3564_RS05860	COG0088	Forms part of the polypeptide exit tunnel
AP3564_RS05865	COG0089	rRNA binding
AP3564_RS05870	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AP3564_RS05875	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AP3564_RS05880	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AP3564_RS05885	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AP3564_RS05895	COG0255	Belongs to the universal ribosomal protein uL29 family
AP3564_RS05900	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AP3564_RS05905	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AP3564_RS05915	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AP3564_RS05920	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AP3564_RS05925	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AP3564_RS05935	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AP3564_RS05940	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AP3564_RS05950	COG0200	Binds to the 23S rRNA
AP3564_RS05955	COG0201	protein transport
AP3564_RS05960	COG0563	adenylate kinase activity
AP3564_RS05965	COG0024	Methionine aminopeptidase
AP3564_RS05975	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AP3564_RS05980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AP3564_RS05985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AP3564_RS05990	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AP3564_RS06000	COG0203	ribosomal protein L17
AP3564_RS06005	COG1122	ATPase activity
AP3564_RS06010	COG1122	ATPase activity
AP3564_RS06015	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AP3564_RS06020	COG0101	tRNA pseudouridine synthase activity
AP3564_RS06025	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AP3564_RS06030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AP3564_RS06060	COG0860	N-Acetylmuramoyl-L-alanine amidase
AP3564_RS06065	COG0489	protein tyrosine kinase activity
AP3564_RS06075	COG2194	sulfuric ester hydrolase activity
AP3564_RS06085	COG0726	polysaccharide deacetylase
AP3564_RS06170	COG1595	DNA-templated transcription, initiation
AP3564_RS06175	COG5662	AntiSigma factor
AP3564_RS06180	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AP3564_RS06185	COG4856	YbbR-like protein
AP3564_RS06190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AP3564_RS06195	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AP3564_RS06210	COG0789	Transcriptional regulator
AP3564_RS06215	COG1253	flavin adenine dinucleotide binding
AP3564_RS06240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AP3564_RS06245	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AP3564_RS06245	COG0446	pyridine nucleotide-disulphide oxidoreductase
AP3564_RS06265	COG1609	Transcriptional regulator
AP3564_RS06270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AP3564_RS06280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AP3564_RS06285	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AP3564_RS06290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AP3564_RS06300	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AP3564_RS06305	COG1063	alcohol dehydrogenase
AP3564_RS06310	COG0800	Aldolase
AP3564_RS06315	COG1312	Catalyzes the dehydration of D-mannonate
AP3564_RS06320	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_RS06365	COG1113	amino acid transport
AP3564_RS06375	COG0583	DNA-binding transcription factor activity
AP3564_RS06380	COG2070	2-Nitropropane dioxygenase
AP3564_RS06395	COG0277	FAD linked oxidase domain protein
AP3564_RS06400	COG0247	lactate metabolic process
AP3564_RS06405	COG0277	FAD linked oxidase domain protein
AP3564_RS06410	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AP3564_RS06420	COG1414	Transcriptional regulator
AP3564_RS06425	COG1620	l-lactate permease
AP3564_RS06430	COG1937	Protein conserved in bacteria
AP3564_RS06435	COG0534	Mate efflux family protein
AP3564_RS06440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AP3564_RS06445	COG0765	amino acid transport
AP3564_RS06450	COG1126	abc transporter atp-binding protein
AP3564_RS06475	COG2076	Multidrug Resistance protein
AP3564_RS06480	COG2076	Multidrug Resistance protein
AP3564_RS06490	COG4806	L-rhamnose isomerase
AP3564_RS06495	COG1070	Carbohydrate kinase
AP3564_RS06500	COG0588	phosphoglycerate mutase activity
AP3564_RS06510	COG2972	Histidine kinase
AP3564_RS06515	COG2207	Transcriptional regulator
AP3564_RS06520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AP3564_RS06525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AP3564_RS06530	COG1129	ABC transporter
AP3564_RS06535	COG1172	Belongs to the binding-protein-dependent transport system permease family
AP3564_RS06545	COG1879	ABC-type sugar transport system periplasmic component
AP3564_RS06560	COG1413	lyase activity
AP3564_RS06570	COG1131	(ABC) transporter
AP3564_RS06575	COG1266	CAAX protease self-immunity
AP3564_RS06580	COG0535	radical SAM domain protein
AP3564_RS06590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AP3564_RS06595	COG2814	Major facilitator Superfamily
AP3564_RS06610	COG3832	glyoxalase III activity
AP3564_RS06625	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AP3564_RS06645	COG1472	Belongs to the glycosyl hydrolase 3 family
AP3564_RS06660	COG1114	Component of the transport system for branched-chain amino acids
AP3564_RS06675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AP3564_RS06680	COG3885	ferrous iron binding
AP3564_RS06680	COG2078	PFAM AMMECR1 domain protein
AP3564_RS06695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AP3564_RS06715	COG1414	Transcriptional regulator
AP3564_RS06725	COG0483	inositol monophosphate 1-phosphatase activity
AP3564_RS06730	COG2186	Transcriptional regulator
AP3564_RS06735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AP3564_RS06745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AP3564_RS06750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AP3564_RS06775	COG0693	protein deglycase activity
AP3564_RS06785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AP3564_RS06790	COG0702	epimerase
AP3564_RS06795	COG2807	transmembrane transport
AP3564_RS06815	COG2807	transmembrane transport
AP3564_RS06820	COG3842	ATPase activity
AP3564_RS06825	COG1175	transmembrane transport
AP3564_RS06830	COG0395	ABC-type sugar transport system, permease component
AP3564_RS06835	COG1653	transport
AP3564_RS06840	COG0584	glycerophosphoryl diester phosphodiesterase
AP3564_RS06845	COG0745	RESPONSE REGULATOR receiver
AP3564_RS06850	COG3850	Histidine kinase
AP3564_RS06850	COG5002	protein histidine kinase activity
AP3564_RS06855	COG2514	catechol 2,3-dioxygenase activity
AP3564_RS06870	COG0069	glutamate synthase activity
AP3564_RS06875	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AP3564_RS06880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AP3564_RS06885	COG1011	Hydrolase
AP3564_RS06890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_RS06895	COG1181	Belongs to the D-alanine--D-alanine ligase family
AP3564_RS06900	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AP3564_RS06905	COG0513	Belongs to the DEAD box helicase family
AP3564_RS06910	COG3402	PFAM membrane-flanked domain
AP3564_RS06915	COG3428	Bacterial PH domain
AP3564_RS06920	COG0705	Rhomboid family
AP3564_RS06925	COG0736	holo-[acyl-carrier-protein] synthase activity
AP3564_RS06930	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AP3564_RS06940	COG0864	Transcriptional regulator
AP3564_RS06945	COG2337	Toxic component of a toxin-antitoxin (TA) module
AP3564_RS06955	COG1366	Belongs to the anti-sigma-factor antagonist family
AP3564_RS06960	COG1366	Belongs to the anti-sigma-factor antagonist family
AP3564_RS06965	COG2172	sigma factor antagonist activity
AP3564_RS06970	COG2208	phosphoserine phosphatase activity
AP3564_RS06975	COG1366	Belongs to the anti-sigma-factor antagonist family
AP3564_RS06985	COG1191	sigma factor activity
AP3564_RS06990	COG2208	phosphoserine phosphatase activity
AP3564_RS06995	COG2183	response to ionizing radiation
AP3564_RS07005	COG3091	SprT-like family
AP3564_RS07085	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AP3564_RS07090	COG0802	atpase or kinase
AP3564_RS07095	COG1214	PFAM Peptidase M22, glycoprotease
AP3564_RS07100	COG0456	acetyltransferase
AP3564_RS07105	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AP3564_RS07110	COG0488	(ABC) transporter
AP3564_RS07115	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AP3564_RS07120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AP3564_RS07125	COG0805	protein transport
AP3564_RS07135	COG1266	CAAX protease self-immunity
AP3564_RS07140	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AP3564_RS07145	COG0459	protein refolding
AP3564_RS07150	COG3739	integral membrane protein
AP3564_RS07185	COG1082	Xylose isomerase domain protein TIM barrel
AP3564_RS07200	COG0501	Belongs to the peptidase M48B family
AP3564_RS07225	COG1131	(ABC) transporter
AP3564_RS07250	COG1349	DNA-binding transcription factor activity
AP3564_RS07255	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_RS07260	COG3718	enzyme involved in inositol metabolism
AP3564_RS07265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AP3564_RS07270	COG3962	Belongs to the TPP enzyme family
AP3564_RS07275	COG1082	Xylose isomerase domain protein TIM barrel
AP3564_RS07285	COG0673	inositol 2-dehydrogenase activity
AP3564_RS07290	COG1129	ABC transporter
AP3564_RS07295	COG1172	Belongs to the binding-protein-dependent transport system permease family
AP3564_RS07300	COG1879	ABC-type sugar transport system periplasmic component
AP3564_RS07305	COG0673	inositol 2-dehydrogenase activity
AP3564_RS07310	COG0191	fructose-bisphosphate aldolase activity
AP3564_RS07325	COG0247	lactate metabolic process
AP3564_RS07330	COG0277	FAD linked oxidase domain protein
AP3564_RS07335	COG2186	Transcriptional regulator
AP3564_RS07345	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_RS07350	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AP3564_RS07355	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AP3564_RS07370	COG1914	H( )-stimulated, divalent metal cation uptake system
AP3564_RS07375	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AP3564_RS07380	COG1984	allophanate hydrolase subunit 2
AP3564_RS07385	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AP3564_RS07390	COG1414	Transcriptional regulator
AP3564_RS07410	COG4336	lyase activity
AP3564_RS07435	COG3711	transcriptional antiterminator
AP3564_RS07460	COG1131	(ABC) transporter
AP3564_RS07475	COG3842	ATPase activity
AP3564_RS07490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AP3564_RS07505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AP3564_RS07510	COG0303	'Molybdopterin
AP3564_RS07520	COG0803	Belongs to the bacterial solute-binding protein 9 family
AP3564_RS07525	COG1121	(ABC) transporter
AP3564_RS07530	COG1321	iron dependent repressor
AP3564_RS07530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AP3564_RS07535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AP3564_RS07540	COG1321	iron dependent repressor
AP3564_RS07550	COG3764	Sortase (surface protein transpeptidase)
AP3564_RS07555	COG1113	amino acid transport
AP3564_RS07560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AP3564_RS07560	COG4499	WXG100 protein secretion system (Wss), protein YukC
AP3564_RS07575	COG0681	Belongs to the peptidase S26 family
AP3564_RS07620	COG3730	PTS system glucitol sorbitol-specific
AP3564_RS07625	COG3732	PTS system glucitol sorbitol-specific
AP3564_RS07635	COG2390	Transcriptional regulator
AP3564_RS07640	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AP3564_RS07645	COG0508	dehydrogenase complex catalyzes the overall conversion of
AP3564_RS07645	COG0022	dehydrogenase e1 component
AP3564_RS07650	COG0508	dehydrogenase complex catalyzes the overall conversion of
AP3564_RS07655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AP3564_RS07660	COG2390	Transcriptional regulator
AP3564_RS07670	COG3290	protein histidine kinase activity
AP3564_RS07675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AP3564_RS07680	COG1301	dicarboxylic acid transport
AP3564_RS07685	COG1482	cell wall glycoprotein biosynthetic process
AP3564_RS07700	COG1316	TRANSCRIPTIONal
AP3564_RS07710	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AP3564_RS07720	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AP3564_RS07730	COG0463	Glycosyl transferase, family 2
AP3564_RS07740	COG2076	Multidrug Resistance protein
AP3564_RS07760	COG4193	domain, Protein
AP3564_RS07765	COG0728	peptidoglycan biosynthetic process
AP3564_RS07770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AP3564_RS07775	COG0438	transferase activity, transferring glycosyl groups
AP3564_RS07780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AP3564_RS07785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AP3564_RS07790	COG1316	TRANSCRIPTIONal
AP3564_RS07795	COG1739	Uncharacterized protein family UPF0029
AP3564_RS07800	COG4585	Histidine kinase
AP3564_RS07805	COG2197	response regulator
AP3564_RS07810	COG1307	EDD domain protein, DegV family
AP3564_RS07815	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AP3564_RS07825	COG1040	competence protein
AP3564_RS07845	COG1256	bacterial-type flagellum assembly
AP3564_RS07845	COG4786	Flagellar basal body rod
AP3564_RS07850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AP3564_RS07860	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AP3564_RS07865	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AP3564_RS07870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AP3564_RS07875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AP3564_RS07895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AP3564_RS07900	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AP3564_RS07905	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AP3564_RS07910	COG2089	acid synthase
AP3564_RS07920	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AP3564_RS07940	COG2337	Toxic component of a toxin-antitoxin (TA) module
AP3564_RS07960	COG0604	alcohol dehydrogenase
AP3564_RS07975	COG1309	transcriptional regulator
AP3564_RS07980	COG1388	LysM domain
AP3564_RS07980	COG3584	3D domain protein
AP3564_RS07990	COG0670	Belongs to the BI1 family
AP3564_RS07995	COG3829	transcription factor binding
AP3564_RS07995	COG3290	protein histidine kinase activity
AP3564_RS08000	COG1454	alcohol dehydrogenase
AP3564_RS08010	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_RS08015	COG2814	Major facilitator Superfamily
AP3564_RS08025	COG3711	transcriptional antiterminator
AP3564_RS08030	COG2723	6-phospho-beta-galactosidase activity
AP3564_RS08035	COG2723	6-phospho-beta-galactosidase activity
AP3564_RS08040	COG1263	PTS System
AP3564_RS08040	COG2190	(PTS) system
AP3564_RS08040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AP3564_RS08050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AP3564_RS08055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AP3564_RS08060	COG1116	anion transmembrane transporter activity
AP3564_RS08065	COG5278	phosphoserine phosphatase activity
AP3564_RS08065	COG0840	transmembrane signaling receptor activity
AP3564_RS08075	COG3665	Urea carboxylase-associated protein
AP3564_RS08080	COG0439	Biotin carboxylase
AP3564_RS08090	COG1172	Belongs to the binding-protein-dependent transport system permease family
AP3564_RS08095	COG1879	ABC-type sugar transport system periplasmic component
AP3564_RS08100	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AP3564_RS08110	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AP3564_RS08120	COG1454	alcohol dehydrogenase
AP3564_RS08135	COG2508	Transcriptional regulator
AP3564_RS08175	COG3344	reverse transcriptase
AP3564_RS08180	COG2723	6-phospho-beta-galactosidase activity
AP3564_RS08210	COG4152	abc transporter atp-binding protein
AP3564_RS08215	COG1668	transmembrane transport
AP3564_RS08220	COG0840	transmembrane signaling receptor activity
AP3564_RS08225	COG3347	Dehydrogenase
AP3564_RS08225	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_RS08230	COG1349	DNA-binding transcription factor activity
AP3564_RS08235	COG4154	Belongs to the RbsD FucU family
AP3564_RS08240	COG1070	Carbohydrate kinase
AP3564_RS08245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AP3564_RS08250	COG1129	ABC transporter
AP3564_RS08265	COG1172	Belongs to the binding-protein-dependent transport system permease family
AP3564_RS08275	COG0235	Class ii aldolase
AP3564_RS08280	COG1070	Carbohydrate kinase
AP3564_RS08290	COG1069	ribulokinase activity
AP3564_RS08295	COG0183	Belongs to the thiolase family
AP3564_RS08300	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AP3564_RS08305	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AP3564_RS08310	COG0583	DNA-binding transcription factor activity
AP3564_RS08315	COG0145	ligase activity
AP3564_RS08320	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
AP3564_RS08325	COG4647	ligase activity
AP3564_RS08340	COG4585	Histidine kinase
AP3564_RS08345	COG2197	response regulator
AP3564_RS08350	COG1131	(ABC) transporter
AP3564_RS08365	COG1132	(ABC) transporter
AP3564_RS08390	COG1376	ErfK ybiS ycfS ynhG family protein
AP3564_RS08400	COG3842	ATPase activity
AP3564_RS08405	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AP3564_RS08420	COG1442	glycosyl transferase family 8
AP3564_RS08435	COG2508	Transcriptional regulator
AP3564_RS08440	COG1250	3-hydroxyacyl-CoA dehydrogenase
AP3564_RS08445	COG1024	Enoyl-CoA hydratase
AP3564_RS08450	COG0318	PFAM AMP-dependent synthetase and ligase
AP3564_RS08460	COG1960	acyl-CoA dehydrogenase activity
AP3564_RS08470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AP3564_RS08480	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AP3564_RS08495	COG0179	Fumarylacetoacetate (FAA) hydrolase
AP3564_RS08515	COG1334	flagellar protein FlaG
AP3564_RS08520	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AP3564_RS08525	COG1516	flagellar protein fliS
AP3564_RS08535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AP3564_RS08540	COG0653	protein targeting
AP3564_RS08550	COG2010	Cytochrome c
AP3564_RS08555	COG2884	Cell division ATP-binding protein ftsE
AP3564_RS08560	COG2177	Part of the ABC transporter FtsEX involved in
AP3564_RS08565	COG0739	heme binding
AP3564_RS08570	COG0793	Belongs to the peptidase S41A family
AP3564_RS08570	COG3409	Peptidoglycan-binding domain 1 protein
AP3564_RS08580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AP3564_RS08585	COG2072	flavoprotein involved in K transport
AP3564_RS08590	COG1230	cation diffusion facilitator family transporter
AP3564_RS08595	COG0640	Transcriptional regulator
AP3564_RS08625	COG1940	carbohydrate kinase activity
AP3564_RS08635	COG0556	nucleotide-excision repair
AP3564_RS08640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AP3564_RS08650	COG1960	acyl-CoA dehydrogenase activity
AP3564_RS08660	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AP3564_RS08665	COG0765	amino acid transport
AP3564_RS08670	COG0765	amino acid transport
AP3564_RS08685	COG1950	PFAM Membrane protein of
AP3564_RS08690	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AP3564_RS08695	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AP3564_RS08700	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AP3564_RS08705	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AP3564_RS08710	COG0546	phosphoglycolate phosphatase activity
AP3564_RS08715	COG0110	maltose O-acetyltransferase activity
AP3564_RS08720	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AP3564_RS08725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AP3564_RS08730	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AP3564_RS08735	COG0131	Imidazoleglycerol-phosphate dehydratase
AP3564_RS08740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AP3564_RS08745	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AP3564_RS08750	COG0107	imidazoleglycerol-phosphate synthase activity
AP3564_RS08755	COG0140	phosphoribosyl-ATP diphosphatase activity
AP3564_RS08755	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AP3564_RS08760	COG0457	Tetratricopeptide repeat
AP3564_RS08765	COG0492	ferredoxin-NADP+ reductase activity
AP3564_RS08770	COG1051	belongs to the nudix hydrolase family
AP3564_RS08775	COG1660	Displays ATPase and GTPase activities
AP3564_RS08780	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AP3564_RS08785	COG1481	regulation of sporulation
AP3564_RS08790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP3564_RS08795	COG0740	serine-type endopeptidase activity
AP3564_RS08810	COG3279	Response regulator of the LytR AlgR family
AP3564_RS08815	COG0427	acetyl-CoA hydrolase
AP3564_RS08820	COG1929	Belongs to the glycerate kinase type-1 family
AP3564_RS08830	COG1486	melibiose metabolic process
AP3564_RS08885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AP3564_RS08890	COG1609	Transcriptional regulator
AP3564_RS08895	COG0477	Major facilitator Superfamily
AP3564_RS08915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AP3564_RS08930	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AP3564_RS08950	COG0126	phosphoglycerate kinase activity
AP3564_RS08965	COG0148	phosphopyruvate hydratase activity
AP3564_RS08975	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AP3564_RS08980	COG1647	Serine aminopeptidase, S33
AP3564_RS08985	COG0557	exoribonuclease II activity
AP3564_RS08990	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AP3564_RS09005	COG0788	formyltetrahydrofolate deformylase activity
AP3564_RS09010	COG0789	Transcriptional regulator
AP3564_RS09015	COG0114	fumarate hydratase activity
AP3564_RS09025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AP3564_RS09030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AP3564_RS09035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AP3564_RS09040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AP3564_RS09045	COG1120	ATPase activity
AP3564_RS09060	COG5577	PFAM Coat F domain
AP3564_RS09070	COG1024	Enoyl-CoA hydratase
AP3564_RS09070	COG1250	3-hydroxyacyl-CoA dehydrogenase
AP3564_RS09075	COG0183	Belongs to the thiolase family
AP3564_RS09080	COG1960	acyl-CoA dehydrogenase activity
AP3564_RS09085	COG1393	Belongs to the ArsC family
AP3564_RS09090	COG0509	glycine decarboxylation via glycine cleavage system
AP3564_RS09095	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AP3564_RS09100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_RS09110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AP3564_RS09115	COG2011	ABC-type metal ion transport system permease component
AP3564_RS09120	COG1464	Belongs to the NlpA lipoprotein family
AP3564_RS09130	COG0396	ATPase activity
AP3564_RS09135	COG0719	Fe-S assembly protein
AP3564_RS09140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AP3564_RS09145	COG0822	iron-sulfur transferase activity
AP3564_RS09150	COG0719	Fe-S assembly protein
AP3564_RS09165	COG1801	Protein of unknown function DUF72
AP3564_RS09170	COG0737	Belongs to the 5'-nucleotidase family
AP3564_RS09175	COG3377	Domain of unknown function (DUF1805)
AP3564_RS09180	COG0739	heme binding
AP3564_RS09185	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AP3564_RS09195	COG4470	Protein conserved in bacteria
AP3564_RS09210	COG2445	Protein of unknown function DUF86
AP3564_RS09215	COG0647	UMP catabolic process
AP3564_RS09220	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AP3564_RS09225	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AP3564_RS09230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AP3564_RS09235	COG0460	homoserine dehydrogenase
AP3564_RS09240	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AP3564_RS09245	COG0083	homoserine kinase activity
AP3564_RS09250	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AP3564_RS09255	COG4837	Protein of unknown function (DUF1462)
AP3564_RS09260	COG1252	NADH dehydrogenase
AP3564_RS09270	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AP3564_RS09275	COG0316	Belongs to the HesB IscA family
AP3564_RS09280	COG0492	ferredoxin-NADP+ reductase activity
AP3564_RS09285	COG1252	NADH dehydrogenase
AP3564_RS09295	COG3584	3D domain protein
AP3564_RS09300	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AP3564_RS09310	COG0686	Belongs to the AlaDH PNT family
AP3564_RS09315	COG1418	mRNA catabolic process
AP3564_RS09340	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_RS09345	COG2610	gluconate transmembrane transporter activity
AP3564_RS09375	COG0142	geranyltranstransferase activity
AP3564_RS09385	COG4585	Histidine kinase
AP3564_RS09390	COG2197	response regulator
AP3564_RS09395	COG1320	monovalent cation:proton antiporter activity
AP3564_RS09400	COG2212	antiporter activity
AP3564_RS09405	COG1863	multisubunit Na H antiporter MnhE subunit
AP3564_RS09410	COG0651	ATP synthesis coupled electron transport
AP3564_RS09415	COG1006	Multisubunit Na H antiporter MnhC subunit
AP3564_RS09420	COG2111	Na H antiporter
AP3564_RS09425	COG2111	Na H antiporter
AP3564_RS09425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AP3564_RS09435	COG3011	Protein conserved in bacteria
AP3564_RS09440	COG5018	Exonuclease
AP3564_RS09455	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AP3564_RS09465	COG2267	carboxylic ester hydrolase activity
AP3564_RS09470	COG1522	sequence-specific DNA binding
AP3564_RS09475	COG0436	Aminotransferase
AP3564_RS09480	COG1098	S1 RNA binding domain
AP3564_RS09485	COG2155	Conserved Protein
AP3564_RS09490	COG0166	Belongs to the GPI family
AP3564_RS09500	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AP3564_RS09510	COG2738	Putative neutral zinc metallopeptidase
AP3564_RS09515	COG0432	Pfam Uncharacterised protein family UPF0047
AP3564_RS09640	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AP3564_RS09645	COG1575	Belongs to the MenA family. Type 1 subfamily
AP3564_RS09650	COG1169	isochorismate synthase
AP3564_RS09660	COG0596	Alpha beta hydrolase
AP3564_RS09665	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AP3564_RS09670	COG0318	PFAM AMP-dependent synthetase and ligase
AP3564_RS09680	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AP3564_RS09685	COG1854	S-ribosylhomocysteine lyase activity
AP3564_RS09690	COG0783	Belongs to the Dps family
AP3564_RS09700	COG0494	nUDIX hydrolase
AP3564_RS09705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AP3564_RS09710	COG1116	anion transmembrane transporter activity
AP3564_RS09715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AP3564_RS09720	COG1506	peptidase
AP3564_RS09735	COG2801	Transposase and inactivated derivatives
AP3564_RS09745	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AP3564_RS09750	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AP3564_RS09760	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AP3564_RS09775	COG2267	carboxylic ester hydrolase activity
AP3564_RS09785	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AP3564_RS09790	COG1242	4 iron, 4 sulfur cluster binding
AP3564_RS09800	COG1725	Transcriptional regulator
AP3564_RS09805	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AP3564_RS09810	COG0495	leucyl-tRNA aminoacylation
AP3564_RS09815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AP3564_RS09825	COG1648	precorrin-2 dehydrogenase activity
AP3564_RS09825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AP3564_RS09840	COG2801	Transposase and inactivated derivatives
AP3564_RS09845	COG2081	HI0933 family
AP3564_RS09850	COG2244	polysaccharide biosynthetic process
AP3564_RS09855	COG1187	pseudouridine synthase activity
AP3564_RS09860	COG1349	DNA-binding transcription factor activity
AP3564_RS09870	COG2252	PERMEase
AP3564_RS09875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AP3564_RS09880	COG2076	Multidrug Resistance protein
AP3564_RS09885	COG2076	Multidrug Resistance protein
AP3564_RS09890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AP3564_RS09900	COG1380	Effector of murein hydrolase LrgA
AP3564_RS09905	COG1346	cytolysis
AP3564_RS09915	COG0510	thiamine kinase activity
AP3564_RS09925	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AP3564_RS09930	COG0010	Belongs to the arginase family
AP3564_RS09935	COG5584	Small secreted protein
AP3564_RS09940	COG1363	Peptidase, m42
AP3564_RS09945	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AP3564_RS09950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_RS09955	COG4848	Belongs to the UPF0354 family
AP3564_RS09960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AP3564_RS09965	COG1288	antiporter activity
AP3564_RS09970	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AP3564_RS09975	COG2224	Isocitrate lyase
AP3564_RS09985	COG4903	ComK protein
AP3564_RS09995	COG0398	Pfam SNARE associated Golgi protein
AP3564_RS10000	COG0681	Belongs to the peptidase S26 family
AP3564_RS10005	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AP3564_RS10010	COG1074	ATP-dependent DNA helicase activity
AP3564_RS10015	COG1074	ATP-dependent DNA helicase activity
AP3564_RS10020	COG0420	3'-5' exonuclease activity
AP3564_RS10025	COG0419	ATPase involved in DNA repair
AP3564_RS10060	COG1959	2 iron, 2 sulfur cluster binding
AP3564_RS10065	COG5583	Uncharacterized small protein (DUF2292)
AP3564_RS10070	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AP3564_RS10075	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AP3564_RS10080	COG4208	sulfate ABC transporter
AP3564_RS10090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AP3564_RS10105	COG0084	hydrolase, TatD family'
AP3564_RS10110	COG0179	Fumarylacetoacetate (FAA) hydrolase
AP3564_RS10125	COG0367	asparagine synthase
AP3564_RS10145	COG2706	6-phosphogluconolactonase activity
AP3564_RS10150	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AP3564_RS10160	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_RS10165	COG1410	methionine synthase
AP3564_RS10165	COG0646	methionine synthase
AP3564_RS10170	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AP3564_RS10170	COG0646	methionine synthase
AP3564_RS10175	COG1666	GTP binding
AP3564_RS10200	COG1307	EDD domain protein, DegV family
AP3564_RS10210	COG0561	phosphatase activity
AP3564_RS10215	COG1073	alpha beta
AP3564_RS10220	COG2151	metal-sulfur cluster biosynthetic enzyme
AP3564_RS10225	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AP3564_RS10230	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AP3564_RS10245	COG0505	Belongs to the CarA family
AP3564_RS10250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AP3564_RS10255	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AP3564_RS10285	COG1744	ABC transporter substrate-binding protein PnrA-like
AP3564_RS10295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AP3564_RS10300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AP3564_RS10310	COG5504	Zn-dependent protease
AP3564_RS10325	COG0180	Tryptophanyl-tRNA synthetase
AP3564_RS10330	COG1393	Belongs to the ArsC family
AP3564_RS10335	COG0861	Integral membrane protein TerC family
AP3564_RS10340	COG4862	establishment of competence for transformation
AP3564_RS10345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AP3564_RS10350	COG4469	Competence protein
AP3564_RS10355	COG1164	Oligoendopeptidase f
AP3564_RS10370	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AP3564_RS10375	COG2346	COG2346, Truncated hemoglobins
AP3564_RS10380	COG0741	lytic transglycosylase activity
AP3564_RS10385	COG4116	CYTH
AP3564_RS10395	COG2357	RelA SpoT domain protein
AP3564_RS10405	COG0564	pseudouridine synthase activity
AP3564_RS10410	COG2239	Acts as a magnesium transporter
AP3564_RS10415	COG0569	domain protein
AP3564_RS10415	COG0475	glutathione-regulated potassium exporter activity
AP3564_RS10420	COG0352	thiamine-phosphate diphosphorylase activity
AP3564_RS10425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AP3564_RS10430	COG2104	thiamine diphosphate biosynthetic process
AP3564_RS10435	COG2022	thiamine diphosphate biosynthetic process
AP3564_RS10440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AP3564_RS10445	COG0351	phosphomethylpyrimidine kinase
AP3564_RS10450	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AP3564_RS10510	COG2323	membrane
AP3564_RS10515	COG2153	protein acetylation
AP3564_RS10520	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AP3564_RS10525	COG2382	esterase
AP3564_RS10540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AP3564_RS10550	COG0626	cystathionine gamma-synthase activity
AP3564_RS10555	COG0626	cystathionine gamma-synthase activity
AP3564_RS10560	COG2358	TRAP transporter, solute receptor (TAXI family
AP3564_RS10580	COG0658	competence protein
AP3564_RS10580	COG2333	competence protein COMEC
AP3564_RS10590	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AP3564_RS10600	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AP3564_RS10630	COG1024	Enoyl-CoA hydratase
AP3564_RS10635	COG0477	Major facilitator Superfamily
AP3564_RS10675	COG4990	cell redox homeostasis
AP3564_RS10680	COG0367	asparagine synthase
AP3564_RS10710	COG2801	Transposase and inactivated derivatives
AP3564_RS10805	COG1263	PTS System
AP3564_RS10805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AP3564_RS10810	COG0366	Alpha amylase catalytic
AP3564_RS10815	COG2188	Transcriptional regulator
AP3564_RS10830	COG3344	reverse transcriptase
AP3564_RS10885	COG5002	protein histidine kinase activity
AP3564_RS10885	COG3850	Histidine kinase
AP3564_RS10890	COG0745	RESPONSE REGULATOR receiver
AP3564_RS10920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_RS10925	COG0785	Cytochrome C biogenesis protein
AP3564_RS10930	COG1937	Protein conserved in bacteria
AP3564_RS10935	COG2217	Heavy metal translocating P-type atpase
AP3564_RS10950	COG2132	Multicopper oxidase
AP3564_RS10965	COG4372	Transposase
AP3564_RS10970	COG1609	Transcriptional regulator
AP3564_RS10975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AP3564_RS10975	COG1263	PTS System
AP3564_RS10980	COG1621	beta-fructofuranosidase activity
AP3564_RS10985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AP3564_RS10990	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AP3564_RS10995	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AP3564_RS11010	COG0717	Belongs to the dCTP deaminase family
AP3564_RS11015	COG0523	cobalamin synthesis protein
AP3564_RS11035	COG0693	protein deglycase activity
AP3564_RS11040	COG3835	regulator
AP3564_RS11045	COG0277	FAD linked oxidase domain protein
AP3564_RS11050	COG0247	lactate metabolic process
AP3564_RS11055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_RS11100	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AP3564_RS11125	COG4372	Transposase
AP3564_RS11160	COG3344	reverse transcriptase
AP3564_RS11180	COG2358	TRAP transporter, solute receptor (TAXI family
AP3564_RS11195	COG0277	FAD linked oxidase domain protein
AP3564_RS11200	COG0247	lactate metabolic process
AP3564_RS11205	COG0579	oxidoreductase
AP3564_RS11245	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AP3564_RS11265	COG4988	ABC transporter
AP3564_RS11270	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AP3564_RS11275	COG1294	oxidase, subunit
AP3564_RS11280	COG1271	oxidase subunit
AP3564_RS11290	COG1131	(ABC) transporter
AP3564_RS11305	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AP3564_RS11310	COG3383	formate dehydrogenase (NAD+) activity
AP3564_RS11315	COG2427	Protein of unknown function (DUF1641)
AP3564_RS11320	COG0326	Molecular chaperone. Has ATPase activity
AP3564_RS11330	COG1408	metallophosphoesterase
AP3564_RS11340	COG2814	Major facilitator Superfamily
AP3564_RS11355	COG0179	Fumarylacetoacetate (FAA) hydrolase
AP3564_RS11365	COG0824	Thioesterase
AP3564_RS11370	COG1021	2,3-dihydroxybenzoate-AMP ligase
AP3564_RS11380	COG2884	Cell division ATP-binding protein ftsE
AP3564_RS11395	COG3328	transposase activity
AP3564_RS11410	COG0840	transmembrane signaling receptor activity
AP3564_RS11435	COG1476	TRANSCRIPTIONal
AP3564_RS11440	COG1414	Transcriptional regulator
AP3564_RS11445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AP3564_RS11485	COG1250	3-hydroxyacyl-CoA dehydrogenase
AP3564_RS11490	COG1250	3-hydroxyacyl-CoA dehydrogenase
AP3564_RS11495	COG0183	Belongs to the thiolase family
AP3564_RS11500	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_RS11505	COG1024	Enoyl-CoA hydratase
AP3564_RS11520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AP3564_RS11530	COG2151	metal-sulfur cluster biosynthetic enzyme
AP3564_RS11545	COG1024	Enoyl-CoA hydratase
AP3564_RS11550	COG1024	Enoyl-CoA hydratase
AP3564_RS11565	COG0318	PFAM AMP-dependent synthetase and ligase
AP3564_RS11570	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AP3564_RS11590	COG1725	Transcriptional regulator
AP3564_RS11595	COG1131	(ABC) transporter
AP3564_RS11605	COG1595	DNA-templated transcription, initiation
AP3564_RS11630	COG2322	membrane
AP3564_RS11635	COG0589	response to stress
AP3564_RS11665	COG2801	Transposase and inactivated derivatives
AP3564_RS11690	COG0726	polysaccharide deacetylase
AP3564_RS11700	COG0492	ferredoxin-NADP+ reductase activity
AP3564_RS11705	COG3773	Cell wall hydrolase
AP3564_RS11725	COG3344	reverse transcriptase
AP3564_RS11745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AP3564_RS11750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AP3564_RS11755	COG1120	ATPase activity
AP3564_RS11760	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AP3564_RS11765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AP3564_RS11780	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AP3564_RS11805	COG0789	Transcriptional regulator
AP3564_RS11810	COG1253	flavin adenine dinucleotide binding
AP3564_RS11815	COG3002	Belongs to the UPF0753 family
AP3564_RS11820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AP3564_RS11825	COG5609	conserved protein (DUF2294)
AP3564_RS11830	COG0527	aspartate kinase activity
AP3564_RS11835	COG0840	transmembrane signaling receptor activity
AP3564_RS11840	COG1846	Transcriptional regulator
AP3564_RS11845	COG5001	Diguanylate cyclase
AP3564_RS11845	COG3300	MHYT domain
AP3564_RS11855	COG1793	dna ligase
AP3564_RS11855	COG3285	dna ligase
AP3564_RS11860	COG0131	Imidazoleglycerol-phosphate dehydratase
AP3564_RS11860	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AP3564_RS11865	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AP3564_RS11870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AP3564_RS11880	COG4175	Glycine betaine
AP3564_RS11880	COG0517	IMP dehydrogenase activity
AP3564_RS11915	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AP3564_RS11920	COG0768	penicillin binding
AP3564_RS11930	COG1032	radical SAM domain protein
AP3564_RS11935	COG2186	Transcriptional regulator
AP3564_RS11940	COG0247	lactate metabolic process
AP3564_RS11945	COG1139	Iron-sulfur cluster binding protein
AP3564_RS11950	COG1556	Lactate utilization protein
AP3564_RS11955	COG3594	Acyltransferase
AP3564_RS11960	COG5002	protein histidine kinase activity
AP3564_RS11965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AP3564_RS11970	COG3853	Toxic anion resistance protein (TelA)
AP3564_RS11975	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
AP3564_RS11980	COG0393	Putative heavy-metal-binding
AP3564_RS12000	COG3852	Histidine kinase
AP3564_RS12005	COG1846	Transcriptional regulator
AP3564_RS12020	COG1360	Flagellar Motor Protein
AP3564_RS12025	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AP3564_RS12030	COG0542	response to heat
AP3564_RS12035	COG3949	Membrane
AP3564_RS12040	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AP3564_RS12045	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AP3564_RS12050	COG0720	synthase
AP3564_RS12060	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AP3564_RS12065	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AP3564_RS12070	COG4873	Protein conserved in bacteria
AP3564_RS12100	COG2244	polysaccharide biosynthetic process
AP3564_RS12105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_RS12110	COG2217	Heavy metal translocating P-type atpase
AP3564_RS12120	COG1525	nuclease
AP3564_RS12125	COG0205	6-phosphofructokinase activity
AP3564_RS12145	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AP3564_RS12150	COG3711	transcriptional antiterminator
AP3564_RS12155	COG2190	(PTS) system
AP3564_RS12155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AP3564_RS12155	COG1263	PTS System
AP3564_RS12160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP3564_RS12165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AP3564_RS12170	COG0840	transmembrane signaling receptor activity
AP3564_RS12175	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_RS12180	COG2084	Dehydrogenase
AP3564_RS12185	COG2340	Cysteine-rich secretory protein family
AP3564_RS12190	COG0768	penicillin binding
AP3564_RS12195	COG4191	Histidine kinase
AP3564_RS12200	COG0436	Aminotransferase
AP3564_RS12205	COG0598	Magnesium transport protein CorA
AP3564_RS12220	COG0784	Response regulator, receiver
AP3564_RS12220	COG0835	chemotaxis
AP3564_RS12230	COG0640	Transcriptional regulator
AP3564_RS12235	COG2814	Major facilitator Superfamily
AP3564_RS12240	COG1408	metallophosphoesterase
AP3564_RS12255	COG2200	EAL domain
AP3564_RS12265	COG1120	ATPase activity
AP3564_RS12275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AP3564_RS12280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AP3564_RS12285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AP3564_RS12295	COG0517	IMP dehydrogenase activity
AP3564_RS12300	COG0477	Major facilitator Superfamily
AP3564_RS12305	COG0583	DNA-binding transcription factor activity
AP3564_RS12310	COG2171	N-acyltransferase activity
AP3564_RS12315	COG1473	amidohydrolase
AP3564_RS12320	COG0668	transmembrane transport
AP3564_RS12325	COG0450	alkyl hydroperoxide reductase
AP3564_RS12330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_RS12340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AP3564_RS12345	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AP3564_RS12350	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AP3564_RS12360	COG1122	ATPase activity
AP3564_RS12395	COG0831	urea catabolic process
AP3564_RS12400	COG0832	Belongs to the urease beta subunit family
AP3564_RS12410	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AP3564_RS12450	COG1119	ATPase activity
AP3564_RS12455	COG0402	S-adenosylhomocysteine deaminase activity
AP3564_RS12490	COG0402	S-adenosylhomocysteine deaminase activity
AP3564_RS12495	COG0655	NAD(P)H dehydrogenase (quinone) activity
AP3564_RS12500	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AP3564_RS12510	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AP3564_RS12515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AP3564_RS12520	COG2080	2 iron, 2 sulfur cluster binding
AP3564_RS12535	COG2351	hydroxyisourate hydrolase activity
AP3564_RS12545	COG2233	PERMEase
AP3564_RS12550	COG2508	Transcriptional regulator
AP3564_RS12555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AP3564_RS12560	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AP3564_RS12565	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AP3564_RS12580	COG0673	inositol 2-dehydrogenase activity
AP3564_RS12590	COG1061	Type III restriction enzyme res subunit
AP3564_RS12635	COG2195	Cleaves the N-terminal amino acid of tripeptides
AP3564_RS12665	COG1349	DNA-binding transcription factor activity
AP3564_RS12670	COG1105	Belongs to the carbohydrate kinase PfkB family
AP3564_RS12675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AP3564_RS12675	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AP3564_RS12675	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AP3564_RS12695	COG1492	cobalamin metabolic process
AP3564_RS12705	COG3835	regulator
AP3564_RS12710	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AP3564_RS12715	COG2059	Chromate
AP3564_RS12720	COG2059	Chromate
AP3564_RS12725	COG1522	sequence-specific DNA binding
AP3564_RS12740	COG0405	Gamma-glutamyltransferase
AP3564_RS12760	COG4152	abc transporter atp-binding protein
AP3564_RS12765	COG1131	(ABC) transporter
AP3564_RS12770	COG2188	Transcriptional regulator
AP3564_RS12785	COG1331	Highly conserved protein containing a thioredoxin domain
AP3564_RS12805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AP3564_RS12825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AP3564_RS12830	COG1136	(ABC) transporter
AP3564_RS12835	COG0577	efflux transmembrane transporter activity
AP3564_RS12840	COG0772	Belongs to the SEDS family
AP3564_RS12865	COG2309	aminopeptidase activity
AP3564_RS12870	COG1960	acyl-CoA dehydrogenase activity
AP3564_RS12875	COG2223	nitrite transmembrane transporter activity
AP3564_RS12890	COG0583	DNA-binding transcription factor activity
AP3564_RS12895	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AP3564_RS12900	COG4637	Psort location Cytoplasmic, score
AP3564_RS12905	COG0569	domain protein
AP3564_RS12910	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AP3564_RS12915	COG5503	Protein of unknown function (DUF1447)
AP3564_RS12920	COG0561	phosphatase activity
AP3564_RS12925	COG0242	peptide deformylase activity
AP3564_RS12940	COG0022	dehydrogenase e1 component
AP3564_RS12945	COG0508	dehydrogenase complex catalyzes the overall conversion of
AP3564_RS12955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_RS12965	COG1476	TRANSCRIPTIONal
AP3564_RS12985	COG1131	(ABC) transporter
AP3564_RS13020	COG0697	spore germination
AP3564_RS13025	COG1982	Orn Lys Arg decarboxylase major
AP3564_RS13050	COG4493	Belongs to the UPF0637 family
AP3564_RS13055	COG0483	inositol monophosphate 1-phosphatase activity
AP3564_RS13065	COG1217	gtp-binding protein TYPA
AP3564_RS13075	COG4896	Protein conserved in bacteria
AP3564_RS13085	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AP3564_RS13090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AP3564_RS13095	COG4838	Belongs to the UPF0358 family
AP3564_RS13100	COG0772	Belongs to the SEDS family
AP3564_RS13105	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AP3564_RS13120	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AP3564_RS13130	COG0328	RNA-DNA hybrid ribonuclease activity
AP3564_RS13145	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AP3564_RS13150	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AP3564_RS13155	COG0386	Belongs to the glutathione peroxidase family
AP3564_RS13160	COG1413	lyase activity
AP3564_RS13175	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AP3564_RS13180	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AP3564_RS13185	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AP3564_RS13190	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AP3564_RS13200	COG1307	EDD domain protein, DegV family
AP3564_RS13205	COG1999	signal sequence binding
AP3564_RS13240	COG2755	lipolytic protein G-D-S-L family
AP3564_RS13245	COG4698	Protein conserved in bacteria
AP3564_RS13250	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AP3564_RS13250	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AP3564_RS13260	COG2814	Major facilitator Superfamily
AP3564_RS13265	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AP3564_RS13265	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AP3564_RS13280	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AP3564_RS13285	COG4479	Belongs to the UPF0346 family
AP3564_RS13300	COG0515	serine threonine protein kinase
AP3564_RS13305	COG4326	sporulation control protein
AP3564_RS13315	COG0671	phosphoesterase, PA-phosphatase related
AP3564_RS13330	COG1876	peptidase activity
AP3564_RS13335	COG0793	Belongs to the peptidase S41A family
AP3564_RS13335	COG3409	Peptidoglycan-binding domain 1 protein
AP3564_RS13355	COG2962	Rard protein
AP3564_RS13365	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AP3564_RS13370	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AP3564_RS13375	COG0791	NLP P60 protein
AP3564_RS13375	COG1388	LysM domain
AP3564_RS13400	COG0833	amino acid
AP3564_RS13405	COG0714	Associated with various cellular activities
AP3564_RS13410	COG4548	von Willebrand factor, type A
AP3564_RS13415	COG0567	Dehydrogenase, E1 component
AP3564_RS13420	COG0508	dehydrogenase complex catalyzes the overall conversion of
AP3564_RS13430	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AP3564_RS13435	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AP3564_RS13445	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_RS13465	COG3546	catalase activity
AP3564_RS13475	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AP3564_RS13530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AP3564_RS13545	COG2323	membrane
AP3564_RS13550	COG0492	ferredoxin-NADP+ reductase activity
AP3564_RS13565	COG0129	dihydroxy-acid dehydratase activity
AP3564_RS13570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AP3564_RS13580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AP3564_RS13600	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_RS13605	COG0534	Mate efflux family protein
AP3564_RS13615	COG0477	Major facilitator Superfamily
AP3564_RS13620	COG1309	transcriptional regulator
AP3564_RS13625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AP3564_RS13650	COG0840	transmembrane signaling receptor activity
AP3564_RS13675	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_RS13680	COG1937	Protein conserved in bacteria
AP3564_RS13685	COG2217	Heavy metal translocating P-type atpase
AP3564_RS13690	COG2608	mercury ion transmembrane transporter activity
AP3564_RS13725	COG2199	diguanylate cyclase activity
AP3564_RS13725	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AP3564_RS13750	COG1566	PFAM secretion protein HlyD family protein
AP3564_RS13755	COG2814	Major facilitator Superfamily
AP3564_RS13770	COG2258	MOSC domain
AP3564_RS13785	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AP3564_RS13790	COG2079	MmgE PrpD family protein
AP3564_RS13795	COG0372	Belongs to the citrate synthase family
AP3564_RS13810	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AP3564_RS13815	COG0667	Aldo Keto reductase
AP3564_RS13820	COG0723	plastoquinol--plastocyanin reductase activity
AP3564_RS13820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AP3564_RS13825	COG3275	phosphorelay sensor kinase activity
AP3564_RS13835	COG1966	Carbon starvation protein
AP3564_RS13840	COG1309	transcriptional regulator
AP3564_RS13845	COG0673	inositol 2-dehydrogenase activity
AP3564_RS13850	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AP3564_RS13870	COG3226	Transcriptional regulator
AP3564_RS13885	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AP3564_RS13900	COG1595	DNA-templated transcription, initiation
AP3564_RS13910	COG1846	Transcriptional regulator
AP3564_RS13915	COG2409	Drug exporters of the RND superfamily
AP3564_RS13915	COG1033	growth of symbiont in host cell
AP3564_RS13920	COG1388	LysM domain
AP3564_RS13920	COG3858	chitin binding
AP3564_RS13940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AP3564_RS13940	COG0551	DNA topoisomerase type I activity
AP3564_RS13945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AP3564_RS13965	COG2814	Major facilitator Superfamily
AP3564_RS13980	COG0561	phosphatase activity
AP3564_RS13990	COG1509	lysine 2,3-aminomutase activity
AP3564_RS13995	COG3239	Fatty acid desaturase
AP3564_RS14000	COG4585	Histidine kinase
AP3564_RS14005	COG2197	response regulator
AP3564_RS14015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AP3564_RS14015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AP3564_RS14025	COG1253	flavin adenine dinucleotide binding
AP3564_RS14035	COG0564	pseudouridine synthase activity
AP3564_RS14055	COG0366	Alpha amylase catalytic
AP3564_RS14060	COG0517	IMP dehydrogenase activity
AP3564_RS14070	COG4221	oxidoreductase activity
AP3564_RS14075	COG4585	Histidine kinase
AP3564_RS14075	COG2203	Gaf domain
AP3564_RS14080	COG2197	response regulator
AP3564_RS14085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AP3564_RS14090	COG0366	Alpha amylase catalytic
AP3564_RS14100	COG2879	small protein
AP3564_RS14110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AP3564_RS14115	COG2104	thiamine diphosphate biosynthetic process
AP3564_RS14120	COG2022	thiamine diphosphate biosynthetic process
AP3564_RS14135	COG3842	ATPase activity
AP3564_RS14140	COG2508	Transcriptional regulator
AP3564_RS14165	COG0367	asparagine synthase
AP3564_RS14170	COG0534	Mate efflux family protein
AP3564_RS14175	COG1917	Cupin 2, conserved barrel domain protein
AP3564_RS14175	COG2207	Transcriptional regulator
AP3564_RS14185	COG2182	Extracellular solute-binding protein
AP3564_RS14190	COG1175	transmembrane transport
AP3564_RS14195	COG3833	ABC-type maltose transport systems, permease component
AP3564_RS14200	COG0366	Alpha amylase catalytic
AP3564_RS14215	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AP3564_RS14225	COG2963	transposase activity
AP3564_RS14230	COG3153	acetyltransferase
AP3564_RS14230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AP3564_RS14250	COG1937	Protein conserved in bacteria
AP3564_RS14255	COG0425	Belongs to the sulfur carrier protein TusA family
AP3564_RS14260	COG2210	Belongs to the sulfur carrier protein TusA family
AP3564_RS14270	COG0589	response to stress
AP3564_RS14290	COG0785	Cytochrome C biogenesis protein
AP3564_RS14295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_RS14300	COG0745	RESPONSE REGULATOR receiver
AP3564_RS14305	COG2205	protein histidine kinase activity
AP3564_RS14310	COG3858	chitin binding
AP3564_RS14310	COG1388	LysM domain
AP3564_RS14315	COG2210	Belongs to the sulfur carrier protein TusA family
AP3564_RS14325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AP3564_RS14325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AP3564_RS14330	COG2226	methyltransferase
AP3564_RS14340	COG1937	Protein conserved in bacteria
AP3564_RS14345	COG0425	Belongs to the sulfur carrier protein TusA family
AP3564_RS14350	COG2210	Belongs to the sulfur carrier protein TusA family
AP3564_RS14360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AP3564_RS14365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AP3564_RS14365	COG0425	Belongs to the sulfur carrier protein TusA family
AP3564_RS14370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AP3564_RS14370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AP3564_RS14375	COG0425	Belongs to the sulfur carrier protein TusA family
AP3564_RS14380	COG0730	response to heat
AP3564_RS14405	COG0583	DNA-binding transcription factor activity
AP3564_RS14420	COG2217	Heavy metal translocating P-type atpase
AP3564_RS14465	COG0640	Transcriptional regulator
AP3564_RS14470	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_RS14470	COG1454	alcohol dehydrogenase
AP3564_RS14495	COG1683	Conserved Protein
AP3564_RS14505	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
AP3564_RS14515	COG0156	8-amino-7-oxononanoate synthase activity
AP3564_RS14520	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AP3564_RS14525	COG3290	protein histidine kinase activity
AP3564_RS14525	COG3829	transcription factor binding
AP3564_RS14535	COG1454	alcohol dehydrogenase
AP3564_RS14550	COG0640	Transcriptional regulator
AP3564_RS14560	COG3655	Transcriptional regulator
AP3564_RS14585	COG0385	Bile acid
AP3564_RS14600	COG0488	(ABC) transporter
AP3564_RS14605	COG0500	methyltransferase
AP3564_RS14620	COG1309	transcriptional regulator
AP3564_RS14625	COG1960	acyl-CoA dehydrogenase activity
AP3564_RS14630	COG0318	PFAM AMP-dependent synthetase and ligase
AP3564_RS14635	COG0439	Biotin carboxylase
AP3564_RS14640	COG0511	ligase activity, forming carbon-carbon bonds
AP3564_RS14645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AP3564_RS14650	COG1024	Enoyl-CoA hydratase
AP3564_RS14655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AP3564_RS14660	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AP3564_RS14665	COG4149	molybdate abc transporter
AP3564_RS14670	COG1910	domain protein
AP3564_RS14685	COG3344	reverse transcriptase
AP3564_RS14695	COG0725	ABC transporter, periplasmic molybdate-binding protein
AP3564_RS14705	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_RS14710	COG3586	endonuclease activity
AP3564_RS14720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AP3564_RS14730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AP3564_RS14735	COG2011	ABC-type metal ion transport system permease component
AP3564_RS14740	COG0640	Transcriptional regulator
AP3564_RS14745	COG0798	PFAM Bile acid sodium symporter
AP3564_RS14750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AP3564_RS14755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AP3564_RS14760	COG1279	arginine transmembrane transporter activity
AP3564_RS14765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AP3564_RS14770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AP3564_RS14775	COG2226	methyltransferase
AP3564_RS14815	COG4372	Transposase
AP3564_RS14830	COG0531	amino acid
AP3564_RS14835	COG1725	Transcriptional regulator
AP3564_RS14910	COG1131	(ABC) transporter
AP3564_RS14915	COG1064	alcohol dehydrogenase
AP3564_RS14925	COG1309	transcriptional regulator
AP3564_RS14930	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_RS14935	COG2207	Transcriptional regulator
AP3564_RS14940	COG0656	L-ascorbic acid biosynthetic process
AP3564_RS14980	COG0390	transport system, permease component
AP3564_RS15000	COG0315	cyclic pyranopterin monophosphate synthase activity
AP3564_RS15015	COG0314	molybdopterin synthase activity
AP3564_RS15020	COG1763	Mo-molybdopterin cofactor biosynthetic process
AP3564_RS15025	COG0303	'Molybdopterin
AP3564_RS15030	COG0746	molybdenum cofactor guanylyltransferase activity
AP3564_RS15065	COG2151	metal-sulfur cluster biosynthetic enzyme
AP3564_RS15075	COG0535	radical SAM domain protein
AP3564_RS15080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AP3564_RS15105	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AP3564_RS15110	COG0187	DNA topoisomerase II activity
AP3564_RS15115	COG1832	CoA-binding protein
AP3564_RS15120	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AP3564_RS15125	COG1199	ATP-dependent helicase activity
AP3564_RS15125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AP3564_RS15135	COG0004	ammonium transporteR
AP3564_RS15145	COG4841	protein insertion into membrane
AP3564_RS15155	COG0824	Thioesterase
AP3564_RS15175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_RS15180	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AP3564_RS15205	COG4846	Membrane protein involved in cytochrome C biogenesis
AP3564_RS15210	COG2201	protein-glutamate methylesterase activity
AP3564_RS15215	COG0785	Cytochrome C biogenesis protein
AP3564_RS15220	COG3763	UPF0154 protein
AP3564_RS15235	COG4224	UPF0291 protein
AP3564_RS15240	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AP3564_RS15250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AP3564_RS15255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AP3564_RS15260	COG0204	Acyl-transferase
AP3564_RS15265	COG1611	Belongs to the LOG family
AP3564_RS15270	COG0667	Aldo Keto reductase
AP3564_RS15275	COG0400	carboxylic ester hydrolase activity
AP3564_RS15280	COG0346	lactoylglutathione lyase activity
AP3564_RS15290	COG1609	Transcriptional regulator
AP3564_RS15315	COG4585	Histidine kinase
AP3564_RS15320	COG2197	response regulator
AP3564_RS15330	COG0840	transmembrane signaling receptor activity
AP3564_RS15340	COG2200	EAL domain
AP3564_RS15370	COG3180	Ammonia monooxygenase
AP3564_RS15375	COG0583	DNA-binding transcription factor activity
AP3564_RS15390	COG1012	belongs to the aldehyde dehydrogenase family
AP3564_RS15395	COG0745	RESPONSE REGULATOR receiver
AP3564_RS15400	COG5002	protein histidine kinase activity
AP3564_RS15400	COG3850	Histidine kinase
AP3564_RS15410	COG0310	cobalt ion transport
AP3564_RS15445	COG1136	(ABC) transporter
AP3564_RS15485	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_RS15500	COG3739	integral membrane protein
AP3564_RS15510	COG1970	mechanosensitive ion channel activity
AP3564_RS15620	COG0835	chemotaxis
AP3564_RS15620	COG0784	Response regulator, receiver
AP3564_RS15735	COG0405	Gamma-glutamyltransferase
AP3564_RS15745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AP3564_RS15770	COG0395	ABC-type sugar transport system, permease component
AP3564_RS15775	COG1175	transmembrane transport
AP3564_RS15780	COG1653	transport
AP3564_RS15795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AP3564_RS15800	COG2188	Transcriptional regulator
AP3564_RS15810	COG2222	sugar isomerase
AP3564_RS15825	COG0210	DNA helicase
AP3564_RS15835	COG1074	ATP-dependent DNA helicase activity
AP3564_RS15965	COG1070	Carbohydrate kinase
AP3564_RS15970	COG1609	Transcriptional regulator
AP3564_RS15975	COG0310	cobalt ion transport
AP3564_RS15985	COG1122	ATPase activity
AP3564_RS16015	COG4565	transcriptional regulatory protein
AP3564_RS16020	COG3290	protein histidine kinase activity
AP3564_RS16035	COG3181	Tripartite tricarboxylate transporter family receptor
AP3564_RS16045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AP3564_RS16060	COG0439	Biotin carboxylase
AP3564_RS16065	COG0511	ligase activity, forming carbon-carbon bonds
AP3564_RS16070	COG5016	pyruvate
AP3564_RS16070	COG0511	ligase activity, forming carbon-carbon bonds
AP3564_RS16080	COG1414	Transcriptional regulator
AP3564_RS16085	COG1414	Transcriptional regulator
AP3564_RS16125	COG2801	Transposase and inactivated derivatives
AP3564_RS16195	COG0174	glutamine synthetase
AP3564_RS16200	COG0789	Transcriptional regulator
AP3564_RS16210	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AP3564_RS16215	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AP3564_RS16220	COG0464	growth
AP3564_RS16225	COG1923	regulation of RNA biosynthetic process
AP3564_RS16230	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AP3564_RS16235	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AP3564_RS16240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AP3564_RS16250	COG4550	Control of competence regulator ComK, YlbF/YmcA
AP3564_RS16255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AP3564_RS16260	COG1013	pyruvate-flavodoxin oxidoreductase activity
AP3564_RS16270	COG2359	stage V sporulation protein S
AP3564_RS16275	COG1692	metallophosphoesterase
AP3564_RS16280	COG1418	mRNA catabolic process
AP3564_RS16290	COG1058	Belongs to the CinA family
AP3564_RS16290	COG1546	Belongs to the CinA family
AP3564_RS16295	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AP3564_RS16300	COG1426	Protein conserved in bacteria
AP3564_RS16315	COG0300	oxidoreductase activity
AP3564_RS16320	COG0612	Peptidase, M16
AP3564_RS16325	COG0612	Peptidase, M16
AP3564_RS16345	COG1674	ftsk spoiiie
AP3564_RS16345	COG4980	gas vesicle protein
AP3564_RS16355	COG0740	serine-type endopeptidase activity
AP3564_RS16360	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AP3564_RS16370	COG0527	aspartate kinase activity
AP3564_RS16375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AP3564_RS16380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AP3564_RS16385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AP3564_RS16390	COG1873	PFAM PRC-barrel domain
AP3564_RS16395	COG0612	Peptidase, M16
AP3564_RS16400	COG0726	polysaccharide deacetylase
AP3564_RS16405	COG1185	polyribonucleotide nucleotidyltransferase activity
AP3564_RS16410	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AP3564_RS16415	COG0196	riboflavin kinase activity
AP3564_RS16420	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AP3564_RS16425	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AP3564_RS16430	COG1550	Protein conserved in bacteria
AP3564_RS16435	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AP3564_RS16440	COG1358	cellular component organization or biogenesis
AP3564_RS16445	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AP3564_RS16450	COG0195	Participates in both transcription termination and antitermination
AP3564_RS16455	COG0779	Required for maturation of 30S ribosomal subunits
AP3564_RS16460	COG2176	DNA-directed DNA polymerase activity
AP3564_RS16465	COG0442	prolyl-tRNA aminoacylation
AP3564_RS16470	COG0750	zinc metalloprotease
AP3564_RS16475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AP3564_RS16480	COG4589	Belongs to the CDS family
AP3564_RS16485	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AP3564_RS16490	COG0233	cytoplasmic translational termination
AP3564_RS16495	COG0528	UMP kinase activity
AP3564_RS16500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AP3564_RS16505	COG0052	Belongs to the universal ribosomal protein uS2 family
AP3564_RS16515	COG1191	sigma factor activity
AP3564_RS16520	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AP3564_RS16525	COG1776	CheC inhibitor of MCP methylation
AP3564_RS16530	COG0835	chemotaxis
AP3564_RS16535	COG2198	Histidine kinase
AP3564_RS16535	COG0643	Histidine kinase
AP3564_RS16540	COG2201	protein-glutamate methylesterase activity
AP3564_RS16545	COG0455	bacterial-type flagellum organization
AP3564_RS16550	COG1419	protein localization to endoplasmic reticulum
AP3564_RS16555	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AP3564_RS16560	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AP3564_RS16565	COG1684	flagellar biosynthetic protein fliR
AP3564_RS16570	COG1987	bacterial-type flagellum assembly
AP3564_RS16575	COG1338	Plays a role in the flagellum-specific transport system
AP3564_RS16580	COG3190	flagellar
AP3564_RS16585	COG2201	protein-glutamate methylesterase activity
AP3564_RS16590	COG1776	CheC inhibitor of MCP methylation
AP3564_RS16590	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AP3564_RS16595	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AP3564_RS16600	COG1580	Controls the rotational direction of flagella during chemotaxis
AP3564_RS16605	COG1582	Flagellar protein (FlbD)
AP3564_RS16610	COG4786	Flagellar basal body rod
AP3564_RS16615	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AP3564_RS16620	COG3144	bacterial-type flagellum assembly
AP3564_RS16630	COG2882	bacterial-type flagellum organization
AP3564_RS16635	COG1157	protein secretion by the type III secretion system
AP3564_RS16640	COG1317	bacterial-type flagellum organization
AP3564_RS16645	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AP3564_RS16650	COG1766	The M ring may be actively involved in energy transduction
AP3564_RS16655	COG1677	Flagellar hook-basal body complex protein FliE
AP3564_RS16660	COG1558	bacterial-type flagellum-dependent cell motility
AP3564_RS16665	COG1815	bacterial-type flagellum-dependent cell motility
AP3564_RS16670	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AP3564_RS16675	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AP3564_RS16680	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AP3564_RS16685	COG4974	Belongs to the 'phage' integrase family
AP3564_RS16690	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AP3564_RS16695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AP3564_RS16700	COG0758	DNA mediated transformation
AP3564_RS16705	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AP3564_RS16710	COG0045	succinate-CoA ligase (ADP-forming) activity
AP3564_RS16715	COG2257	FlhB HrpN YscU SpaS Family
AP3564_RS16725	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AP3564_RS16740	COG0335	large ribosomal subunit rRNA binding
AP3564_RS16750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AP3564_RS16765	COG1837	Belongs to the UPF0109 family
AP3564_RS16770	COG0228	four-way junction DNA binding
AP3564_RS16775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AP3564_RS16780	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AP3564_RS16785	COG0552	protein localization to endoplasmic reticulum
AP3564_RS16790	COG1196	nuclear chromosome segregation
AP3564_RS16795	COG0571	ribonuclease III activity
AP3564_RS16800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AP3564_RS16805	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_RS16810	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AP3564_RS16815	COG0416	fatty acid biosynthetic process
AP3564_RS16820	COG1349	DNA-binding transcription factor activity
AP3564_RS16825	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AP3564_RS16830	COG1461	Dihydroxyacetone kinase
AP3564_RS16835	COG1302	Protein conserved in bacteria
AP3564_RS16840	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AP3564_RS16850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AP3564_RS16860	COG0515	serine threonine protein kinase
AP3564_RS16860	COG2815	serine threonine protein kinase
AP3564_RS16865	COG0631	protein serine/threonine phosphatase activity
AP3564_RS16875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AP3564_RS16875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AP3564_RS16880	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AP3564_RS16885	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AP3564_RS16890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AP3564_RS16895	COG1758	RNA polymerase activity
AP3564_RS16900	COG0194	GDP metabolic process
AP3564_RS16905	COG2052	Domain of unknown function (DUF370)
AP3564_RS16910	COG1561	YicC-like family, N-terminal region
AP3564_RS16915	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AP3564_RS16925	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
AP3564_RS16930	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AP3564_RS16940	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AP3564_RS16945	COG0529	Catalyzes the synthesis of activated sulfate
AP3564_RS16950	COG2046	Belongs to the sulfate adenylyltransferase family
AP3564_RS16955	COG0175	sulfate reduction
AP3564_RS16960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AP3564_RS16965	COG0284	orotidine-5'-phosphate decarboxylase activity
AP3564_RS16970	COG0167	dihydroorotate dehydrogenase activity
AP3564_RS16975	COG0543	2 iron, 2 sulfur cluster binding
AP3564_RS16980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AP3564_RS16995	COG0540	Belongs to the ATCase OTCase family
AP3564_RS17005	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AP3564_RS17010	COG0564	pseudouridine synthase activity
AP3564_RS17015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AP3564_RS17020	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AP3564_RS17025	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AP3564_RS17030	COG3599	regulation of cell shape
AP3564_RS17035	COG2302	S4 RNA-binding domain
AP3564_RS17040	COG0762	integral membrane protein
AP3564_RS17045	COG1799	cell septum assembly
AP3564_RS17050	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AP3564_RS17055	COG1496	oxidoreductase activity
AP3564_RS17060	COG1873	PFAM PRC-barrel domain
AP3564_RS17065	COG1191	sigma factor activity
AP3564_RS17070	COG1191	sigma factor activity
AP3564_RS17080	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AP3564_RS17085	COG0849	cell division
AP3564_RS17090	COG3856	small basic protein
AP3564_RS17095	COG3879	Bacterial protein of unknown function (DUF881)
AP3564_RS17100	COG3879	Bacterial protein of unknown function (DUF881)
AP3564_RS17105	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AP3564_RS17110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AP3564_RS17115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AP3564_RS17120	COG0772	Belongs to the SEDS family
AP3564_RS17125	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AP3564_RS17130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AP3564_RS17135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AP3564_RS17140	COG0768	penicillin binding
AP3564_RS17145	COG0768	penicillin binding
AP3564_RS17150	COG4839	cell division protein FtsL
AP3564_RS17155	COG0275	rRNA processing
AP3564_RS17160	COG2001	Belongs to the MraZ family
AP3564_RS17165	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AP3564_RS17175	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AP3564_RS17180	COG0454	-acetyltransferase
AP3564_RS17195	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AP3564_RS17200	COG1399	metal-binding, possibly nucleic acid-binding protein
AP3564_RS17205	COG1323	Belongs to the UPF0348 family
AP3564_RS17210	COG3480	Lon protease (S16) C-terminal proteolytic domain
AP3564_RS17215	COG1752	Esterase of the alpha-beta hydrolase superfamily
AP3564_RS17220	COG3314	Sporulation integral membrane protein YlbJ
AP3564_RS17225	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AP3564_RS17230	COG0742	ribosomal rna small subunit methyltransferase
AP3564_RS17245	COG4471	UPF0298 protein
AP3564_RS17250	COG3679	Belongs to the UPF0342 family
AP3564_RS17275	COG2340	Cysteine-rich secretory protein family
AP3564_RS17280	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AP3564_RS17290	COG3336	cytochrome c oxidase
AP3564_RS17300	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AP3564_RS17305	COG1845	cytochrome c oxidase, subunit III
AP3564_RS17310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AP3564_RS17315	COG2010	Cytochrome c
AP3564_RS17315	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AP3564_RS17320	COG0109	protoheme IX farnesyltransferase activity
AP3564_RS17325	COG1612	heme a metabolic process
AP3564_RS17330	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AP3564_RS17335	COG1199	ATP-dependent helicase activity
AP3564_RS17340	COG0116	Belongs to the methyltransferase superfamily
AP3564_RS17360	COG3359	exonuclease
AP3564_RS17365	COG1205	dead DEAH box helicase
AP3564_RS17365	COG1111	helicase
AP3564_RS17400	COG3331	DNA recombination
AP3564_RS17405	COG4499	WXG100 protein secretion system (Wss), protein YukC
AP3564_RS17405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AP3564_RS17415	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AP3564_RS17420	COG3935	DnaD domain protein
AP3564_RS17425	COG0017	Asparaginyl-tRNA synthetase
AP3564_RS17430	COG0436	Aminotransferase
AP3564_RS17450	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AP3564_RS17455	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AP3564_RS17470	COG0617	tRNA 3'-terminal CCA addition
AP3564_RS17475	COG0438	transferase activity, transferring glycosyl groups
AP3564_RS17480	COG1803	Methylglyoxal synthase
AP3564_RS17485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AP3564_RS17490	COG1694	Mazg nucleotide pyrophosphohydrolase
AP3564_RS17495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AP3564_RS17505	COG4347	Protein of unknown function (DUF1405)
AP3564_RS17520	COG1115	amino acid carrier protein
AP3564_RS17525	COG2010	Cytochrome c
AP3564_RS17525	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AP3564_RS17530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AP3564_RS17555	COG5582	Belongs to the UPF0302 family
AP3564_RS17560	COG0457	Tetratricopeptide repeat
AP3564_RS17575	COG0287	Prephenate dehydrogenase
AP3564_RS17585	COG0159	tryptophan synthase activity
AP3564_RS17595	COG0135	phosphoribosylanthranilate isomerase activity
AP3564_RS17600	COG0134	indole-3-glycerol-phosphate synthase activity
AP3564_RS17605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AP3564_RS17615	COG4401	Chorismate mutase type I
AP3564_RS17620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AP3564_RS17630	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AP3564_RS17635	COG0105	UTP biosynthetic process
AP3564_RS17640	COG0142	geranyltranstransferase activity
AP3564_RS17645	COG2226	methyltransferase
AP3564_RS17650	COG0142	geranyltranstransferase activity
AP3564_RS17660	COG0302	gtp cyclohydrolase
AP3564_RS17665	COG0776	regulation of translation
AP3564_RS17675	COG5337	Spore coat protein CotH
AP3564_RS17680	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AP3564_RS17700	COG1160	GTP binding
AP3564_RS17720	COG0539	negative regulation of cytoplasmic translation
AP3564_RS17725	COG0204	Acyl-transferase
AP3564_RS17730	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AP3564_RS17740	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AP3564_RS17745	COG2959	enzyme of heme biosynthesis
AP3564_RS17750	COG3409	Peptidoglycan-binding domain 1 protein
AP3564_RS17750	COG3773	Cell wall hydrolase
AP3564_RS17755	COG2339	peptidase activity
AP3564_RS17765	COG0492	ferredoxin-NADP+ reductase activity
AP3564_RS17770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AP3564_RS17775	COG4862	establishment of competence for transformation
AP3564_RS17785	COG1388	LysM domain
AP3564_RS17790	COG1266	CAAX protease self-immunity
AP3564_RS17795	COG0514	ATP-dependent DNA helicase (RecQ)
AP3564_RS17800	COG4955	Helix-turn-helix domain
AP3564_RS17810	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AP3564_RS17820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AP3564_RS17830	COG1595	DNA-templated transcription, initiation
AP3564_RS17835	COG2096	Adenosyltransferase
AP3564_RS17840	COG5002	protein histidine kinase activity
AP3564_RS17845	COG0745	RESPONSE REGULATOR receiver
AP3564_RS17850	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AP3564_RS17855	COG1333	cytochrome c biogenesis protein
AP3564_RS17860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AP3564_RS17865	COG1187	pseudouridine synthase activity
AP3564_RS17870	COG0700	Nucleoside recognition
AP3564_RS17875	COG2715	membrane protein required for spore maturation
AP3564_RS17880	COG1686	Belongs to the peptidase S11 family
AP3564_RS17885	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AP3564_RS17890	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AP3564_RS17895	COG1547	Domain of unknown function (DUF309)
AP3564_RS17900	COG0456	acetyltransferase
AP3564_RS17905	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AP3564_RS17910	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AP3564_RS17910	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AP3564_RS17915	COG0307	riboflavin synthase, alpha
AP3564_RS17920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AP3564_RS17920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AP3564_RS17930	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AP3564_RS17935	COG4086	secreted protein
AP3564_RS17940	COG0019	diaminopimelate decarboxylase activity
AP3564_RS17945	COG0697	spore germination
AP3564_RS17950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AP3564_RS17980	COG1366	Belongs to the anti-sigma-factor antagonist family
AP3564_RS17985	COG1686	Belongs to the peptidase S11 family
AP3564_RS18005	COG4974	Belongs to the 'phage' integrase family
AP3564_RS18015	COG0735	belongs to the Fur family
AP3564_RS18020	COG1300	Membrane
AP3564_RS18025	COG1379	DNA repair
AP3564_RS18030	COG0494	nUDIX hydrolase
AP3564_RS18040	COG0667	Aldo Keto reductase
AP3564_RS18050	COG0109	protoheme IX farnesyltransferase activity
AP3564_RS18070	COG0316	Belongs to the HesB IscA family
AP3564_RS18075	COG2226	methyltransferase
AP3564_RS18090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AP3564_RS18100	COG0300	oxidoreductase activity
AP3564_RS18105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AP3564_RS18110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AP3564_RS18115	COG1902	pentaerythritol trinitrate reductase activity
AP3564_RS18130	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AP3564_RS18135	COG1254	Belongs to the acylphosphatase family
AP3564_RS18140	COG4214	carbohydrate transport
AP3564_RS18145	COG1129	ABC transporter
AP3564_RS18185	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AP3564_RS18190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AP3564_RS18195	COG0493	'glutamate synthase
AP3564_RS18200	COG0067	glutamate synthase
AP3564_RS18200	COG0069	glutamate synthase activity
AP3564_RS18200	COG0070	glutamate synthase
AP3564_RS18205	COG0583	DNA-binding transcription factor activity
AP3564_RS18210	COG2195	Cleaves the N-terminal amino acid of tripeptides
AP3564_RS18215	COG4129	membrane
AP3564_RS18225	COG0508	dehydrogenase complex catalyzes the overall conversion of
AP3564_RS18230	COG0022	dehydrogenase e1 component
AP3564_RS18235	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AP3564_RS18240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AP3564_RS18250	COG0745	RESPONSE REGULATOR receiver
AP3564_RS18255	COG0750	zinc metalloprotease
AP3564_RS18260	COG0497	DNA recombination
AP3564_RS18265	COG1438	arginine binding
AP3564_RS18270	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AP3564_RS18275	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AP3564_RS18285	COG0142	geranyltranstransferase activity
AP3564_RS18290	COG1722	exodeoxyribonuclease VII activity
AP3564_RS18295	COG1570	exodeoxyribonuclease VII activity
AP3564_RS18300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AP3564_RS18310	COG1302	Protein conserved in bacteria
AP3564_RS18315	COG0439	Biotin carboxylase
AP3564_RS18320	COG0511	ligase activity, forming carbon-carbon bonds
AP3564_RS18360	COG3854	ATPases associated with a variety of cellular activities
AP3564_RS18365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AP3564_RS18370	COG0006	proline dipeptidase activity
AP3564_RS18375	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AP3564_RS18385	COG3872	metal-dependent enzyme
AP3564_RS18395	COG1752	Esterase of the alpha-beta hydrolase superfamily
AP3564_RS18420	COG0662	Cupin 2, conserved barrel domain protein
AP3564_RS18460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AP3564_RS18465	COG0095	Lipoate-protein ligase
AP3564_RS18470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AP3564_RS18480	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AP3564_RS18485	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AP3564_RS18490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AP3564_RS18525	COG4537	Required for transformation and DNA binding
AP3564_RS18530	COG1459	type II secretion system
AP3564_RS18535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AP3564_RS18555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AP3564_RS18575	COG1368	sulfuric ester hydrolase activity
AP3564_RS18580	COG1940	carbohydrate kinase activity
AP3564_RS18585	COG4483	Protein conserved in bacteria
AP3564_RS18590	COG0457	Tetratricopeptide repeat
AP3564_RS18590	COG0705	Rhomboid family
AP3564_RS18600	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AP3564_RS18605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AP3564_RS18615	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AP3564_RS18620	COG0704	Plays a role in the regulation of phosphate uptake
AP3564_RS18625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AP3564_RS18630	COG0581	inorganic phosphate transmembrane transporter activity
AP3564_RS18635	COG0573	inorganic phosphate transmembrane transporter activity
AP3564_RS18640	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AP3564_RS18645	COG0477	Major facilitator Superfamily
AP3564_RS18660	COG2839	Protein conserved in bacteria
AP3564_RS18665	COG1283	sodium-dependent phosphate transmembrane transporter activity
AP3564_RS18670	COG5521	maltodextrose utilization protein MalA
AP3564_RS18675	COG0840	transmembrane signaling receptor activity
AP3564_RS18680	COG2814	Major facilitator Superfamily
AP3564_RS18685	COG1388	LysM domain
AP3564_RS18690	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AP3564_RS18700	COG4709	membrane
AP3564_RS18705	COG0735	belongs to the Fur family
AP3564_RS18710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AP3564_RS18715	COG1121	(ABC) transporter
AP3564_RS18720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AP3564_RS18730	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AP3564_RS18735	COG0513	Belongs to the DEAD box helicase family
AP3564_RS18745	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AP3564_RS18750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AP3564_RS18755	COG2384	SAM-dependent methyltransferase
AP3564_RS18760	COG2010	Cytochrome c
AP3564_RS18765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AP3564_RS18770	COG0358	DNA primase activity
AP3564_RS18775	COG1671	Belongs to the UPF0178 family
AP3564_RS18780	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AP3564_RS18785	COG0517	IMP dehydrogenase activity
AP3564_RS18790	COG0751	glycine-tRNA ligase activity
AP3564_RS18795	COG0752	glycyl-tRNA synthetase alpha subunit
AP3564_RS18800	COG1381	Involved in DNA repair and RecF pathway recombination
AP3564_RS18810	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AP3564_RS18815	COG0295	cytidine deaminase activity
AP3564_RS18820	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AP3564_RS18830	COG1480	7TM receptor with intracellular HD hydrolase
AP3564_RS18835	COG1702	phosphate starvation-inducible protein PhoH
AP3564_RS18855	COG4864	UPF0365 protein
AP3564_RS18860	COG1030	water channel activity
AP3564_RS18865	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AP3564_RS18870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AP3564_RS18875	COG0726	polysaccharide deacetylase
AP3564_RS18880	COG1610	YqeY-like protein
AP3564_RS18885	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AP3564_RS18890	COG1283	sodium-dependent phosphate transmembrane transporter activity
AP3564_RS18895	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AP3564_RS18900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AP3564_RS18905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AP3564_RS18910	COG2264	protein methyltransferase activity
AP3564_RS18915	COG0484	heat shock protein binding
AP3564_RS18920	COG0443	Heat shock 70 kDa protein
AP3564_RS18925	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AP3564_RS18930	COG1420	regulation of RNA biosynthetic process
AP3564_RS18935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AP3564_RS18940	COG0481	GTPase activity
AP3564_RS18950	COG0860	N-Acetylmuramoyl-L-alanine amidase
AP3564_RS18960	COG0268	Binds directly to 16S ribosomal RNA
AP3564_RS18965	COG1466	dna polymerase III delta subunit
AP3564_RS18975	COG0658	competence protein
AP3564_RS18975	COG2333	competence protein COMEC
AP3564_RS18980	COG2131	deaminase
AP3564_RS18985	COG1596	polysaccharide export
AP3564_RS18985	COG1555	photosystem II stabilization
AP3564_RS18990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AP3564_RS18995	COG2226	methyltransferase
AP3564_RS19000	COG0799	negative regulation of ribosome biogenesis
AP3564_RS19005	COG1713	HD superfamily hydrolase involved in NAD metabolism
AP3564_RS19010	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AP3564_RS19015	COG1534	Rna-binding protein
AP3564_RS19025	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AP3564_RS19030	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AP3564_RS19050	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AP3564_RS19060	COG0768	penicillin binding
AP3564_RS19065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AP3564_RS19070	COG0826	peptidase U32
AP3564_RS19075	COG0826	peptidase U32
AP3564_RS19080	COG4122	O-methyltransferase activity
AP3564_RS19085	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AP3564_RS19090	COG3906	Belongs to the UPF0473 family
AP3564_RS19095	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AP3564_RS19105	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AP3564_RS19110	COG0628	permease
AP3564_RS19120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AP3564_RS19130	COG0482	sulfurtransferase activity
AP3564_RS19135	COG1104	cysteine desulfurase activity
AP3564_RS19140	COG1959	2 iron, 2 sulfur cluster binding
AP3564_RS19145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AP3564_RS19150	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AP3564_RS19160	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AP3564_RS19165	COG0124	histidyl-tRNA synthetase
AP3564_RS19170	COG0860	N-Acetylmuramoyl-L-alanine amidase
AP3564_RS19170	COG4991	sh3 domain protein
AP3564_RS19170	COG3103	Sh3 type 3 domain protein
AP3564_RS19175	COG1490	D-aminoacyl-tRNA deacylase activity
AP3564_RS19180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AP3564_RS19185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AP3564_RS19190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AP3564_RS19190	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AP3564_RS19195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AP3564_RS19195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AP3564_RS19205	COG2244	polysaccharide biosynthetic process
AP3564_RS19215	COG1862	Preprotein translocase
AP3564_RS19220	COG0343	queuine tRNA-ribosyltransferase activity
AP3564_RS19225	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AP3564_RS19235	COG2255	four-way junction helicase activity
AP3564_RS19240	COG0632	four-way junction helicase activity
AP3564_RS19250	COG0217	transcriptional regulatory protein
AP3564_RS19260	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AP3564_RS19265	COG3344	reverse transcriptase
AP3564_RS19270	COG1388	LysM domain
AP3564_RS19275	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AP3564_RS19280	COG0157	Belongs to the NadC ModD family
AP3564_RS19290	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AP3564_RS19295	COG1104	cysteine desulfurase activity
AP3564_RS19300	COG1827	regulation of RNA biosynthetic process
AP3564_RS19305	COG0077	Prephenate dehydratase
AP3564_RS19310	COG4492	Belongs to the UPF0735 family
AP3564_RS19315	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AP3564_RS19320	COG3290	protein histidine kinase activity
AP3564_RS19325	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AP3564_RS19330	COG2868	ribosomal protein
AP3564_RS19335	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AP3564_RS19340	COG1530	ribonuclease E activity
AP3564_RS19345	COG1994	Peptidase M50
AP3564_RS19350	COG0739	heme binding
AP3564_RS19355	COG1914	H( )-stimulated, divalent metal cation uptake system
AP3564_RS19360	COG0778	Nitroreductase
AP3564_RS19370	COG2894	cell division
AP3564_RS19375	COG0850	regulation of cytokinetic process
AP3564_RS19380	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AP3564_RS19390	COG1077	Cell shape determining protein MreB Mrl
AP3564_RS19395	COG2003	Belongs to the UPF0758 family
AP3564_RS19410	COG0285	dihydrofolate synthase activity
AP3564_RS19430	COG1388	LysM domain
AP3564_RS19435	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AP3564_RS19440	COG0113	porphobilinogen synthase activity
AP3564_RS19445	COG1587	Uroporphyrinogen-III synthase
AP3564_RS19450	COG0181	hydroxymethylbilane synthase activity
AP3564_RS19455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AP3564_RS19470	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AP3564_RS19475	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AP3564_RS19480	COG1067	ATP-dependent peptidase activity
AP3564_RS19480	COG0470	DNA polymerase III
AP3564_RS19485	COG3344	reverse transcriptase
AP3564_RS19500	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AP3564_RS19505	COG0544	peptidyl-prolyl cis-trans isomerase activity
AP3564_RS19510	COG1477	protein flavinylation
AP3564_RS19510	COG0457	Tetratricopeptide repeat
AP3564_RS19515	COG0066	3-isopropylmalate dehydratase activity
AP3564_RS19520	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AP3564_RS19525	COG0473	3-isopropylmalate dehydrogenase activity
AP3564_RS19530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AP3564_RS19535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AP3564_RS19540	COG0440	acetolactate synthase activity
AP3564_RS19545	COG0028	Belongs to the TPP enzyme family
AP3564_RS19550	COG2315	Protein conserved in bacteria
AP3564_RS19560	COG0622	Phosphoesterase
AP3564_RS19565	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AP3564_RS19570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AP3564_RS19575	COG5401	PFAM Sporulation and spore germination
AP3564_RS19580	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AP3564_RS19585	COG1846	Transcriptional regulator
AP3564_RS19590	COG2197	response regulator
AP3564_RS19595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AP3564_RS19600	COG1053	succinate dehydrogenase
AP3564_RS19605	COG2009	succinate dehydrogenase
AP3564_RS19610	COG1719	4-vinyl reductase, 4VR
AP3564_RS19615	COG0322	excinuclease ABC activity
AP3564_RS19620	COG3118	belongs to the thioredoxin family
AP3564_RS19625	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AP3564_RS19630	COG2086	electron transfer activity
AP3564_RS19635	COG1309	transcriptional regulator
AP3564_RS19640	COG0318	PFAM AMP-dependent synthetase and ligase
AP3564_RS19650	COG3766	membrane
AP3564_RS19655	COG1193	negative regulation of DNA recombination
AP3564_RS19670	COG1286	toxin biosynthetic process
AP3564_RS19675	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AP3564_RS19685	COG0072	phenylalanine-tRNA ligase activity
AP3564_RS19685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AP3564_RS19690	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AP3564_RS19700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AP3564_RS19710	COG1363	Peptidase, m42
AP3564_RS19725	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AP3564_RS19730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AP3564_RS19735	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AP3564_RS19745	COG5146	pantothenate kinase activity
AP3564_RS19750	COG3344	reverse transcriptase
AP3564_RS19765	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AP3564_RS19780	COG1484	DNA-dependent DNA replication
AP3564_RS19785	COG3611	Membrane attachment protein
AP3564_RS19790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AP3564_RS19795	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AP3564_RS19800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AP3564_RS19810	COG1971	Probably functions as a manganese efflux pump
AP3564_RS19815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AP3564_RS19820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AP3564_RS19820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AP3564_RS19825	COG0330	HflC and HflK could
AP3564_RS19830	COG0330	HflC and HflK could
AP3564_RS19835	COG5002	protein histidine kinase activity
AP3564_RS19840	COG0745	RESPONSE REGULATOR receiver
AP3564_RS19850	COG0538	isocitrate dehydrogenase activity
AP3564_RS19855	COG0372	Belongs to the citrate synthase family
AP3564_RS19860	COG3030	protein affecting phage T7 exclusion by the F plasmid
AP3564_RS19870	COG0205	6-phosphofructokinase activity
AP3564_RS19880	COG0825	malonyl-CoA metabolic process
AP3564_RS19885	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AP3564_RS19890	COG0281	malic enzyme
AP3564_RS19895	COG0587	DNA-directed DNA polymerase activity
AP3564_RS19910	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AP3564_RS19920	COG4109	DRTGG domain
AP3564_RS19925	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AP3564_RS19930	COG1028	Short-chain dehydrogenase reductase Sdr
AP3564_RS19935	COG0165	Argininosuccinate lyase
AP3564_RS19940	COG0137	argininosuccinate synthase activity
AP3564_RS19960	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AP3564_RS19965	COG0827	DNA restriction-modification system
AP3564_RS19970	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AP3564_RS19975	COG3874	Sporulation protein YtfJ
AP3564_RS19985	COG1714	RDD family
AP3564_RS19990	COG0616	signal peptide processing
AP3564_RS19995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AP3564_RS20005	COG0301	tRNA thio-modification
AP3564_RS20010	COG1104	cysteine desulfurase activity
AP3564_RS20015	COG3842	ATPase activity
AP3564_RS20020	COG0656	L-ascorbic acid biosynthetic process
AP3564_RS20025	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AP3564_RS20030	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AP3564_RS20035	COG1309	transcriptional regulator
AP3564_RS20040	COG1956	GAF domain-containing protein
AP3564_RS20045	COG2199	diguanylate cyclase activity
AP3564_RS20045	COG2203	Gaf domain
AP3564_RS20055	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AP3564_RS20135	COG1830	Aldolase
AP3564_RS20140	COG1063	alcohol dehydrogenase
AP3564_RS20150	COG1737	Transcriptional regulator