locus-tag	class	description
AWM71_RS00045	COG0551	DNA topoisomerase type I activity
AWM71_RS00045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AWM71_RS00060	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AWM71_RS00070	COG0583	DNA-binding transcription factor activity
AWM71_RS00075	COG0588	phosphoglycerate mutase activity
AWM71_RS00085	COG1490	D-aminoacyl-tRNA deacylase activity
AWM71_RS00090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AWM71_RS00095	COG2264	protein methyltransferase activity
AWM71_RS00105	COG3599	regulation of cell shape
AWM71_RS00115	COG0116	Belongs to the methyltransferase superfamily
AWM71_RS00125	COG4716	Myosin-crossreactive antigen
AWM71_RS00130	COG1309	transcriptional regulator
AWM71_RS00160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AWM71_RS00170	COG1114	Component of the transport system for branched-chain amino acids
AWM71_RS00185	COG0183	Belongs to the thiolase family
AWM71_RS00195	COG2610	gluconate transmembrane transporter activity
AWM71_RS00205	COG1024	Enoyl-CoA hydratase
AWM71_RS00210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AWM71_RS00250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AWM71_RS00255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AWM71_RS00260	COG0497	DNA recombination
AWM71_RS00265	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AWM71_RS00270	COG0142	geranyltranstransferase activity
AWM71_RS00275	COG1722	exodeoxyribonuclease VII activity
AWM71_RS00285	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AWM71_RS00290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWM71_RS00305	COG0006	proline dipeptidase activity
AWM71_RS00330	COG2165	general secretion pathway protein
AWM71_RS00335	COG1459	type II secretion system
AWM71_RS00340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AWM71_RS00375	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AWM71_RS00385	COG1394	ATPase activity, coupled to movement of substances
AWM71_RS00400	COG3623	hexulose-6-phosphate isomerase
AWM71_RS00410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWM71_RS00410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWM71_RS00415	COG1378	Sugar-specific transcriptional regulator TrmB
AWM71_RS00445	COG1309	transcriptional regulator
AWM71_RS00460	COG1131	(ABC) transporter
AWM71_RS00490	COG2197	response regulator
AWM71_RS00500	COG1464	Belongs to the NlpA lipoprotein family
AWM71_RS00505	COG0018	arginyl-trna synthetase
AWM71_RS00510	COG2022	thiamine diphosphate biosynthetic process
AWM71_RS00525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AWM71_RS00530	COG0157	Belongs to the NadC ModD family
AWM71_RS00540	COG0431	NADPH-dependent FMN reductase
AWM71_RS00545	COG0588	phosphoglycerate mutase activity
AWM71_RS00550	COG0588	phosphoglycerate mutase activity
AWM71_RS00555	COG1132	(ABC) transporter
AWM71_RS00560	COG1132	(ABC) transporter
AWM71_RS00575	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AWM71_RS00590	COG0204	Acyl-transferase
AWM71_RS00595	COG3763	UPF0154 protein
AWM71_RS00600	COG0564	pseudouridine synthase activity
AWM71_RS00605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AWM71_RS00620	COG1074	ATP-dependent DNA helicase activity
AWM71_RS00625	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AWM71_RS00630	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AWM71_RS00635	COG2384	SAM-dependent methyltransferase
AWM71_RS00665	COG1720	tRNA m6t6A37 methyltransferase activity
AWM71_RS00670	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AWM71_RS00690	COG3590	peptidase
AWM71_RS00695	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AWM71_RS00705	COG1393	Belongs to the ArsC family
AWM71_RS00710	COG0772	Belongs to the SEDS family
AWM71_RS00725	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AWM71_RS00735	COG0301	tRNA thio-modification
AWM71_RS00740	COG1104	cysteine desulfurase activity
AWM71_RS00745	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AWM71_RS00770	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AWM71_RS00785	COG0494	nUDIX hydrolase
AWM71_RS00790	COG1388	LysM domain
AWM71_RS00790	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM71_RS00805	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWM71_RS00815	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AWM71_RS00820	COG3599	regulation of cell shape
AWM71_RS00830	COG0762	integral membrane protein
AWM71_RS00835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AWM71_RS00840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AWM71_RS00850	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AWM71_RS00860	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AWM71_RS00865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AWM71_RS00870	COG0768	penicillin binding
AWM71_RS00880	COG0275	rRNA processing
AWM71_RS00890	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AWM71_RS00895	COG0151	Belongs to the GarS family
AWM71_RS00900	COG0138	bifunctional purine biosynthesis protein purh
AWM71_RS00905	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AWM71_RS00920	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AWM71_RS00925	COG0047	phosphoribosylformylglycinamidine synthase activity
AWM71_RS00930	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AWM71_RS00935	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AWM71_RS00940	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AWM71_RS00945	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AWM71_RS00950	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AWM71_RS00975	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AWM71_RS00980	COG0557	exoribonuclease II activity
AWM71_RS01000	COG0647	UMP catabolic process
AWM71_RS01005	COG4470	Protein conserved in bacteria
AWM71_RS01025	COG1473	amidohydrolase
AWM71_RS01030	COG0148	phosphopyruvate hydratase activity
AWM71_RS01040	COG0126	phosphoglycerate kinase activity
AWM71_RS01055	COG0740	serine-type endopeptidase activity
AWM71_RS01060	COG1178	ABC-type Fe3 transport system permease component
AWM71_RS01065	COG3842	ATPase activity
AWM71_RS01070	COG1840	ABC-type Fe3 transport system, periplasmic component
AWM71_RS01095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWM71_RS01095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM71_RS01095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWM71_RS01100	COG1105	Belongs to the carbohydrate kinase PfkB family
AWM71_RS01105	COG1349	DNA-binding transcription factor activity
AWM71_RS01245	COG0166	Belongs to the GPI family
AWM71_RS01250	COG1098	S1 RNA binding domain
AWM71_RS01255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AWM71_RS01260	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AWM71_RS01265	COG0492	ferredoxin-NADP+ reductase activity
AWM71_RS01270	COG3935	DnaD domain protein
AWM71_RS01275	COG0436	Aminotransferase
AWM71_RS01290	COG0617	tRNA 3'-terminal CCA addition
AWM71_RS01295	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AWM71_RS01310	COG0516	GMP reductase activity
AWM71_RS01310	COG0517	IMP dehydrogenase activity
AWM71_RS01320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AWM71_RS01320	COG1116	anion transmembrane transporter activity
AWM71_RS01340	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AWM71_RS01345	COG1122	ATPase activity
AWM71_RS01350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AWM71_RS01365	COG0802	atpase or kinase
AWM71_RS01370	COG0776	regulation of translation
AWM71_RS01375	COG1160	GTP binding
AWM71_RS01380	COG0539	negative regulation of cytoplasmic translation
AWM71_RS01390	COG1388	LysM domain
AWM71_RS01390	COG3942	CHAP domain
AWM71_RS01395	COG0514	ATP-dependent DNA helicase (RecQ)
AWM71_RS01415	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AWM71_RS01420	COG1187	pseudouridine synthase activity
AWM71_RS01425	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AWM71_RS01430	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AWM71_RS01450	COG4974	Belongs to the 'phage' integrase family
AWM71_RS01455	COG2996	Protein conserved in bacteria
AWM71_RS01470	COG0765	amino acid transport
AWM71_RS01490	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AWM71_RS01495	COG0783	Belongs to the Dps family
AWM71_RS01500	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AWM71_RS01520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AWM71_RS01530	COG0552	protein localization to endoplasmic reticulum
AWM71_RS01535	COG0561	phosphatase activity
AWM71_RS01540	COG1196	nuclear chromosome segregation
AWM71_RS01545	COG0571	ribonuclease III activity
AWM71_RS01555	COG0416	fatty acid biosynthetic process
AWM71_RS01560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AWM71_RS01565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM71_RS01570	COG1461	Dihydroxyacetone kinase
AWM71_RS01575	COG1302	Protein conserved in bacteria
AWM71_RS01580	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AWM71_RS01590	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AWM71_RS01600	COG2815	serine threonine protein kinase
AWM71_RS01600	COG0515	serine threonine protein kinase
AWM71_RS01610	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AWM71_RS01610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWM71_RS01615	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AWM71_RS01620	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AWM71_RS01625	COG1758	RNA polymerase activity
AWM71_RS01630	COG0194	GDP metabolic process
AWM71_RS01640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AWM71_RS01655	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AWM71_RS01665	COG1185	polyribonucleotide nucleotidyltransferase activity
AWM71_RS01680	COG0268	Binds directly to 16S ribosomal RNA
AWM71_RS01700	COG1555	photosystem II stabilization
AWM71_RS01700	COG1596	polysaccharide export
AWM71_RS01705	COG0742	ribosomal rna small subunit methyltransferase
AWM71_RS01715	COG0772	Belongs to the SEDS family
AWM71_RS01720	COG1217	gtp-binding protein TYPA
AWM71_RS01725	COG0483	inositol monophosphate 1-phosphatase activity
AWM71_RS01730	COG4476	Belongs to the UPF0223 family
AWM71_RS01735	COG0765	amino acid transport
AWM71_RS01740	COG0765	amino acid transport
AWM71_RS01745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWM71_RS01775	COG0242	peptide deformylase activity
AWM71_RS01780	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AWM71_RS01785	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AWM71_RS01795	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AWM71_RS01805	COG3425	synthase
AWM71_RS01810	COG4608	Belongs to the ABC transporter superfamily
AWM71_RS01815	COG0444	Belongs to the ABC transporter superfamily
AWM71_RS01820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWM71_RS01825	COG0601	transmembrane transport
AWM71_RS01835	COG4166	transmembrane transport
AWM71_RS01840	COG4166	transmembrane transport
AWM71_RS01860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AWM71_RS01900	COG1876	peptidase activity
AWM71_RS01905	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AWM71_RS01910	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AWM71_RS01920	COG0489	protein tyrosine kinase activity
AWM71_RS01935	COG1051	belongs to the nudix hydrolase family
AWM71_RS01950	COG0516	GMP reductase activity
AWM71_RS01955	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AWM71_RS01965	COG0024	Methionine aminopeptidase
AWM71_RS01975	COG0716	FMN binding
AWM71_RS01985	COG4166	transmembrane transport
AWM71_RS01990	COG0726	polysaccharide deacetylase
AWM71_RS02005	COG1216	Glycosyl transferase, family 2
AWM71_RS02010	COG1216	Glycosyl transferase, family 2
AWM71_RS02020	COG2089	acid synthase
AWM71_RS02025	COG1083	cytidylyl-transferase
AWM71_RS02070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWM71_RS02075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWM71_RS02080	COG1121	(ABC) transporter
AWM71_RS02090	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AWM71_RS02095	COG4466	Protein conserved in bacteria
AWM71_RS02100	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AWM71_RS02105	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AWM71_RS02110	COG0084	hydrolase, TatD family'
AWM71_RS02115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM71_RS02115	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM71_RS02125	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AWM71_RS02140	COG2738	Putative neutral zinc metallopeptidase
AWM71_RS02150	COG0436	Aminotransferase
AWM71_RS02155	COG1522	sequence-specific DNA binding
AWM71_RS02165	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AWM71_RS02170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AWM71_RS02175	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AWM71_RS02200	COG0745	RESPONSE REGULATOR receiver
AWM71_RS02205	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM71_RS02205	COG1388	LysM domain
AWM71_RS02210	COG0697	spore germination
AWM71_RS02215	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AWM71_RS02215	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AWM71_RS02220	COG0561	phosphatase activity
AWM71_RS02230	COG3775	system Galactitol-specific IIC component
AWM71_RS02260	COG3711	transcriptional antiterminator
AWM71_RS02275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM71_RS02275	COG1263	PTS System
AWM71_RS02280	COG2855	membrane
AWM71_RS02295	COG1780	Probably involved in ribonucleotide reductase function
AWM71_RS02315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWM71_RS02320	COG0095	Lipoate-protein ligase
AWM71_RS02330	COG3443	Belongs to the bacterial solute-binding protein 9 family
AWM71_RS02330	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWM71_RS02340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AWM71_RS02345	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AWM71_RS02350	COG0581	inorganic phosphate transmembrane transporter activity
AWM71_RS02355	COG0573	inorganic phosphate transmembrane transporter activity
AWM71_RS02365	COG5002	protein histidine kinase activity
AWM71_RS02370	COG0745	RESPONSE REGULATOR receiver
AWM71_RS02375	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AWM71_RS02380	COG0653	protein targeting
AWM71_RS02390	COG1040	competence protein
AWM71_RS02395	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AWM71_RS02400	COG1739	Uncharacterized protein family UPF0029
AWM71_RS02405	COG0488	(ABC) transporter
AWM71_RS02410	COG0789	Transcriptional regulator
AWM71_RS02415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWM71_RS02435	COG2070	2-Nitropropane dioxygenase
AWM71_RS02440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AWM71_RS02465	COG3730	PTS system glucitol sorbitol-specific
AWM71_RS02470	COG3732	PTS system glucitol sorbitol-specific
AWM71_RS02480	COG2391	methyltransferase activity
AWM71_RS02485	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWM71_RS02495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWM71_RS02500	COG4521	taurine ABC transporter
AWM71_RS02505	COG1116	anion transmembrane transporter activity
AWM71_RS02515	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AWM71_RS02525	COG0708	Exodeoxyribonuclease III
AWM71_RS02535	COG1114	Component of the transport system for branched-chain amino acids
AWM71_RS02540	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AWM71_RS02550	COG3850	Histidine kinase
AWM71_RS02550	COG5002	protein histidine kinase activity
AWM71_RS02555	COG0745	RESPONSE REGULATOR receiver
AWM71_RS02560	COG0629	single-stranded DNA binding
AWM71_RS02565	COG1481	regulation of sporulation
AWM71_RS02570	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AWM71_RS02580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWM71_RS02585	COG0492	ferredoxin-NADP+ reductase activity
AWM71_RS02590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AWM71_RS02595	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AWM71_RS02600	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AWM71_RS02620	COG0419	ATPase involved in DNA repair
AWM71_RS02625	COG0420	3'-5' exonuclease activity
AWM71_RS02630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AWM71_RS02635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AWM71_RS02640	COG1263	PTS System
AWM71_RS02640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM71_RS02640	COG2190	(PTS) system
AWM71_RS02645	COG3394	polysaccharide catabolic process
AWM71_RS02650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM71_RS02650	COG2190	(PTS) system
AWM71_RS02650	COG1263	PTS System
AWM71_RS02655	COG3711	transcriptional antiterminator
AWM71_RS02660	COG2226	methyltransferase
AWM71_RS02665	COG2190	(PTS) system
AWM71_RS02680	COG1477	protein flavinylation
AWM71_RS02685	COG0142	geranyltranstransferase activity
AWM71_RS02690	COG1252	NADH dehydrogenase
AWM71_RS02700	COG1053	succinate dehydrogenase
AWM71_RS02705	COG0318	PFAM AMP-dependent synthetase and ligase
AWM71_RS02715	COG1114	Component of the transport system for branched-chain amino acids
AWM71_RS02740	COG2375	cellular response to nickel ion
AWM71_RS02740	COG1132	(ABC) transporter
AWM71_RS02820	COG2176	DNA-directed DNA polymerase activity
AWM71_RS02845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AWM71_RS02855	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AWM71_RS02860	COG0154	amidase activity
AWM71_RS02875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AWM71_RS02880	COG0210	DNA helicase
AWM71_RS02895	COG1464	Belongs to the NlpA lipoprotein family
AWM71_RS02900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AWM71_RS02930	COG0683	leucine binding
AWM71_RS02940	COG1136	(ABC) transporter
AWM71_RS02950	COG4956	integral membrane protein (PIN domain superfamily)
AWM71_RS02955	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AWM71_RS02960	COG0756	dUTP diphosphatase activity
AWM71_RS02965	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AWM71_RS02975	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM71_RS02980	COG4166	transmembrane transport
AWM71_RS02985	COG1362	aminopeptidase activity
AWM71_RS02990	COG1053	succinate dehydrogenase
AWM71_RS02995	COG0471	metal ion transport
AWM71_RS03000	COG0114	fumarate hydratase activity
AWM71_RS03010	COG1115	amino acid carrier protein
AWM71_RS03015	COG1757	Na H antiporter
AWM71_RS03020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AWM71_RS03035	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AWM71_RS03055	COG0745	RESPONSE REGULATOR receiver
AWM71_RS03070	COG0012	GTP binding
AWM71_RS03075	COG4481	Protein conserved in bacteria
AWM71_RS03080	COG1475	DNA binding
AWM71_RS03085	COG1192	Involved in chromosome partitioning
AWM71_RS03090	COG0357	Ribosomal RNA small subunit methyltransferase G
AWM71_RS03095	COG3275	phosphorelay sensor kinase activity
AWM71_RS03100	COG3279	Response regulator of the LytR AlgR family
AWM71_RS03110	COG1346	cytolysis
AWM71_RS03120	COG0445	tRNA wobble uridine modification
AWM71_RS03125	COG4690	dipeptidase activity
AWM71_RS03130	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AWM71_RS03135	COG3942	CHAP domain
AWM71_RS03135	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM71_RS03140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AWM71_RS03150	COG1328	CTP reductase activity
AWM71_RS03155	COG0602	queuosine metabolic process
AWM71_RS03160	COG0719	Fe-S assembly protein
AWM71_RS03170	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AWM71_RS03175	COG0719	Fe-S assembly protein
AWM71_RS03185	COG2151	metal-sulfur cluster biosynthetic enzyme
AWM71_RS03195	COG0706	membrane insertase activity
AWM71_RS03205	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AWM71_RS03210	COG4166	transmembrane transport
AWM71_RS03225	COG0592	DNA-directed DNA polymerase activity
AWM71_RS03265	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AWM71_RS03270	COG0187	DNA topoisomerase II activity
AWM71_RS03275	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWM71_RS03300	COG0629	single-stranded DNA binding
AWM71_RS03305	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AWM71_RS03315	COG0359	binds to the 23S rRNA
AWM71_RS03320	COG0305	Participates in initiation and elongation during chromosome replication
AWM71_RS03355	COG0504	CTP synthase activity
AWM71_RS03360	COG1473	amidohydrolase
AWM71_RS03415	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AWM71_RS03420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWM71_RS03425	COG4856	YbbR-like protein
AWM71_RS03450	COG0505	Belongs to the CarA family
AWM71_RS03455	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AWM71_RS03465	COG1496	oxidoreductase activity
AWM71_RS03480	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AWM71_RS03485	COG0517	IMP dehydrogenase activity
AWM71_RS03490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AWM71_RS03490	COG0574	Belongs to the PEP-utilizing enzyme family
AWM71_RS03500	COG0583	DNA-binding transcription factor activity
AWM71_RS03505	COG0492	ferredoxin-NADP+ reductase activity
AWM71_RS03510	COG3118	belongs to the thioredoxin family
AWM71_RS03520	COG0483	inositol monophosphate 1-phosphatase activity
AWM71_RS03525	COG2390	Transcriptional regulator
AWM71_RS03530	COG1349	DNA-binding transcription factor activity
AWM71_RS03540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM71_RS03545	COG3037	sugar-specific permease SgaT UlaA
AWM71_RS03560	COG3623	hexulose-6-phosphate isomerase
AWM71_RS03595	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM71_RS03600	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM71_RS03605	COG3715	PTS system
AWM71_RS03610	COG3716	PTS system mannose fructose sorbose family IID component
AWM71_RS03625	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AWM71_RS03645	COG0561	phosphatase activity
AWM71_RS03655	COG1187	pseudouridine synthase activity
AWM71_RS03670	COG1607	acyl-coa hydrolase
AWM71_RS03675	COG1609	Transcriptional regulator
AWM71_RS03680	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AWM71_RS03685	COG1942	4-Oxalocrotonate Tautomerase
AWM71_RS03705	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AWM71_RS03725	COG2176	DNA-directed DNA polymerase activity
AWM71_RS03760	COG1349	DNA-binding transcription factor activity
AWM71_RS03770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM71_RS03790	COG3623	hexulose-6-phosphate isomerase
AWM71_RS03795	COG0235	Class ii aldolase
AWM71_RS03805	COG1735	metal-dependent hydrolase with the TIM-barrel fold
AWM71_RS03820	COG0235	Class ii aldolase
AWM71_RS03825	COG3037	sugar-specific permease SgaT UlaA
AWM71_RS03835	COG2390	Transcriptional regulator
AWM71_RS03840	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AWM71_RS03855	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AWM71_RS03860	COG4224	UPF0291 protein
AWM71_RS03865	COG1214	PFAM Peptidase M22, glycoprotease
AWM71_RS03875	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AWM71_RS03880	COG0488	(ABC) transporter
AWM71_RS03910	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AWM71_RS03925	COG1309	transcriptional regulator
AWM71_RS03955	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AWM71_RS03960	COG1288	antiporter activity
AWM71_RS03965	COG0765	amino acid transport
AWM71_RS03970	COG0165	Argininosuccinate lyase
AWM71_RS03975	COG0765	amino acid transport
AWM71_RS03995	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AWM71_RS04010	COG2801	Transposase and inactivated derivatives
AWM71_RS04020	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AWM71_RS04025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWM71_RS04030	COG3688	RNA-binding protein containing a PIN domain
AWM71_RS04040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AWM71_RS04050	COG0250	Participates in transcription elongation, termination and antitermination
AWM71_RS04065	COG0081	regulation of translation
AWM71_RS04070	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AWM71_RS04075	COG0222	ribosome binding
AWM71_RS04080	COG2813	Specifically methylates the guanine in position
AWM71_RS04090	COG2848	UPF0210 protein
AWM71_RS04100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AWM71_RS04150	COG1230	cation diffusion facilitator family transporter
AWM71_RS04155	COG4463	regulation of RNA biosynthetic process
AWM71_RS04160	COG0542	response to heat
AWM71_RS04170	COG0590	tRNA wobble adenosine to inosine editing
AWM71_RS04180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AWM71_RS04185	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AWM71_RS04190	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AWM71_RS04200	COG0470	DNA polymerase III
AWM71_RS04210	COG4467	Involved in initiation control of chromosome replication
AWM71_RS04215	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AWM71_RS04220	COG2827	Endonuclease containing a URI domain
AWM71_RS04225	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AWM71_RS04230	COG1970	mechanosensitive ion channel activity
AWM71_RS04250	COG0436	Aminotransferase
AWM71_RS04255	COG1078	dGTPase activity
AWM71_RS04260	COG0095	Lipoate-protein ligase
AWM71_RS04270	COG3343	RNA polymerase activity
AWM71_RS04275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AWM71_RS04280	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AWM71_RS04285	COG1609	Transcriptional regulator
AWM71_RS04295	COG0254	rRNA binding
AWM71_RS04300	COG3764	Sortase (surface protein transpeptidase)
AWM71_RS04310	COG1181	Belongs to the D-alanine--D-alanine ligase family
AWM71_RS04315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AWM71_RS04320	COG0513	Belongs to the DEAD box helicase family
AWM71_RS04325	COG0736	holo-[acyl-carrier-protein] synthase activity
AWM71_RS04330	COG1253	flavin adenine dinucleotide binding
AWM71_RS04360	COG2801	Transposase and inactivated derivatives
AWM71_RS04365	COG0463	Glycosyl transferase, family 2
AWM71_RS04405	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AWM71_RS04410	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AWM71_RS04415	COG0193	aminoacyl-tRNA hydrolase activity
AWM71_RS04420	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AWM71_RS04425	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AWM71_RS04435	COG1098	S1 RNA binding domain
AWM71_RS04440	COG0037	tRNA processing
AWM71_RS04450	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AWM71_RS04455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AWM71_RS04460	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AWM71_RS04465	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AWM71_RS04470	COG0049	tRNA binding
AWM71_RS04475	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AWM71_RS04480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AWM71_RS04495	COG0051	transcription antitermination factor activity, RNA binding
AWM71_RS04500	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AWM71_RS04510	COG0089	rRNA binding
AWM71_RS04515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AWM71_RS04520	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AWM71_RS04525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AWM71_RS04535	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AWM71_RS04540	COG0255	Belongs to the universal ribosomal protein uL29 family
AWM71_RS04545	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AWM71_RS04550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AWM71_RS04555	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AWM71_RS04560	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AWM71_RS04565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AWM71_RS04580	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AWM71_RS04585	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AWM71_RS04605	COG0563	adenylate kinase activity
AWM71_RS04615	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AWM71_RS04620	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AWM71_RS04630	COG0202	RNA polymerase activity
AWM71_RS04635	COG0203	ribosomal protein L17
AWM71_RS04640	COG2755	lipolytic protein G-D-S-L family
AWM71_RS04640	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AWM71_RS04645	COG1122	ATPase activity
AWM71_RS04650	COG1122	ATPase activity
AWM71_RS04655	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AWM71_RS04660	COG0101	tRNA pseudouridine synthase activity
AWM71_RS04665	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AWM71_RS04700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AWM71_RS04710	COG3976	FMN-binding domain protein
AWM71_RS04710	COG1053	succinate dehydrogenase
AWM71_RS04710	COG0431	NADPH-dependent FMN reductase
AWM71_RS04725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM71_RS04750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AWM71_RS04765	COG2137	regulation of response to DNA damage stimulus
AWM71_RS04770	COG1194	a g-specific adenine glycosylase
AWM71_RS04775	COG1902	pentaerythritol trinitrate reductase activity
AWM71_RS04800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AWM71_RS04880	COG3104	oligopeptide transport
AWM71_RS04890	COG0517	IMP dehydrogenase activity
AWM71_RS04890	COG0516	GMP reductase activity
AWM71_RS04895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWM71_RS04900	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AWM71_RS04905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWM71_RS04910	COG3679	Belongs to the UPF0342 family
AWM71_RS04915	COG0420	3'-5' exonuclease activity
AWM71_RS04920	COG4717	serine-type aminopeptidase activity
AWM71_RS04925	COG3481	metal-dependent phosphohydrolase, HD sub domain
AWM71_RS04930	COG2003	Belongs to the UPF0758 family
AWM71_RS04940	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AWM71_RS04945	COG1388	LysM domain
AWM71_RS04945	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM71_RS04950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWM71_RS04950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWM71_RS04960	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AWM71_RS04965	COG3611	Membrane attachment protein
AWM71_RS04970	COG1484	DNA-dependent DNA replication
AWM71_RS04975	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AWM71_RS04980	COG2379	hydroxypyruvate reductase
AWM71_RS04985	COG2610	gluconate transmembrane transporter activity
AWM71_RS04995	COG0228	four-way junction DNA binding
AWM71_RS05000	COG1837	Belongs to the UPF0109 family
AWM71_RS05005	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AWM71_RS05025	COG1129	ABC transporter
AWM71_RS05040	COG4988	ABC transporter
AWM71_RS05045	COG1132	(ABC) transporter
AWM71_RS05050	COG0542	response to heat
AWM71_RS05060	COG0343	queuine tRNA-ribosyltransferase activity
AWM71_RS05075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AWM71_RS05080	COG4109	DRTGG domain
AWM71_RS05085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AWM71_RS05090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AWM71_RS05095	COG0513	Belongs to the DEAD box helicase family
AWM71_RS05105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AWM71_RS05115	COG0768	penicillin binding
AWM71_RS05120	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AWM71_RS05125	COG0705	Rhomboid family
AWM71_RS05125	COG0457	Tetratricopeptide repeat
AWM71_RS05130	COG1940	carbohydrate kinase activity
AWM71_RS05135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AWM71_RS05140	COG2094	Belongs to the DNA glycosylase MPG family
AWM71_RS05145	COG0525	valine-tRNA ligase activity
AWM71_RS05150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AWM71_RS05155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AWM71_RS05165	COG0537	adenosine 5'-monophosphoramidase activity
AWM71_RS05170	COG1131	(ABC) transporter
AWM71_RS05180	COG0510	thiamine kinase activity
AWM71_RS05185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AWM71_RS05195	COG0072	phenylalanine-tRNA ligase activity
AWM71_RS05195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM71_RS05205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AWM71_RS05210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AWM71_RS05230	COG1609	Transcriptional regulator
AWM71_RS05235	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AWM71_RS05240	COG0698	ribose 5-phosphate isomerase
AWM71_RS05245	COG2190	(PTS) system
AWM71_RS05245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM71_RS05245	COG1263	PTS System
AWM71_RS05255	COG2190	(PTS) system
AWM71_RS05255	COG1263	PTS System
AWM71_RS05255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM71_RS05260	COG0495	leucyl-tRNA aminoacylation
AWM71_RS05280	COG2244	polysaccharide biosynthetic process
AWM71_RS05285	COG0058	SHG alpha-glucan phosphorylase activity
AWM71_RS05290	COG1609	Transcriptional regulator
AWM71_RS05300	COG2182	Extracellular solute-binding protein
AWM71_RS05305	COG1175	transmembrane transport
AWM71_RS05310	COG3833	ABC-type maltose transport systems, permease component
AWM71_RS05320	COG1640	4-alpha-glucanotransferase
AWM71_RS05325	COG0366	Alpha amylase catalytic
AWM71_RS05330	COG3842	ATPase activity
AWM71_RS05340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM71_RS05345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWM71_RS05350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AWM71_RS05355	COG0072	phenylalanine-tRNA ligase activity
AWM71_RS05355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM71_RS05360	COG1115	amino acid carrier protein
AWM71_RS05365	COG0280	phosphate acetyltransferase
AWM71_RS05385	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AWM71_RS05390	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AWM71_RS05395	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AWM71_RS05400	COG0632	four-way junction helicase activity
AWM71_RS05405	COG2255	four-way junction helicase activity
AWM71_RS05410	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AWM71_RS05415	COG0587	DNA-directed DNA polymerase activity
AWM71_RS05420	COG0205	6-phosphofructokinase activity
AWM71_RS05435	COG0284	orotidine-5'-phosphate decarboxylase activity
AWM71_RS05460	COG0704	Plays a role in the regulation of phosphate uptake
AWM71_RS05470	COG1968	undecaprenyl-diphosphatase activity
AWM71_RS05475	COG2706	6-phosphogluconolactonase activity
AWM71_RS05480	COG0628	permease
AWM71_RS05485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AWM71_RS05490	COG3442	glutamine amidotransferase
AWM71_RS05495	COG1435	thymidine kinase activity
AWM71_RS05505	COG2890	protein-(glutamine-N5) methyltransferase activity
AWM71_RS05510	COG0009	L-threonylcarbamoyladenylate synthase
AWM71_RS05520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AWM71_RS05525	COG0706	membrane insertase activity
AWM71_RS05530	COG1254	Belongs to the acylphosphatase family
AWM71_RS05535	COG1674	ftsk spoiiie
AWM71_RS05540	COG1363	Peptidase, m42
AWM71_RS05545	COG4166	transmembrane transport
AWM71_RS05550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AWM71_RS05555	COG1546	Belongs to the CinA family
AWM71_RS05555	COG1058	Belongs to the CinA family
AWM71_RS05560	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AWM71_RS05570	COG4475	Protein of unknown function (DUF436)
AWM71_RS05585	COG4862	establishment of competence for transformation
AWM71_RS05590	COG1393	Belongs to the ArsC family
AWM71_RS05595	COG0180	Tryptophanyl-tRNA synthetase
AWM71_RS05620	COG0564	pseudouridine synthase activity
AWM71_RS05640	COG1269	ATP hydrolysis coupled proton transport
AWM71_RS05645	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AWM71_RS05655	COG1527	subunit (C
AWM71_RS05670	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
AWM71_RS05675	COG1394	ATPase activity, coupled to movement of substances
AWM71_RS05725	COG0083	homoserine kinase activity
AWM71_RS05730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AWM71_RS05730	COG0519	Catalyzes the synthesis of GMP from XMP
AWM71_RS05740	COG3843	relaxase mobilization nuclease domain protein
AWM71_RS05750	COG3682	Transcriptional regulator
AWM71_RS05755	COG2217	Heavy metal translocating P-type atpase
AWM71_RS05785	COG3290	protein histidine kinase activity
AWM71_RS05790	COG4565	transcriptional regulatory protein
AWM71_RS05800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWM71_RS05815	COG0542	response to heat
AWM71_RS05820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM71_RS05840	COG0438	transferase activity, transferring glycosyl groups
AWM71_RS05855	COG0460	homoserine dehydrogenase
AWM71_RS05860	COG0083	homoserine kinase activity
AWM71_RS05865	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AWM71_RS05870	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AWM71_RS05875	COG1534	Rna-binding protein
AWM71_RS05880	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AWM71_RS05885	COG1713	HD superfamily hydrolase involved in NAD metabolism
AWM71_RS05890	COG0799	negative regulation of ribosome biogenesis
AWM71_RS05895	COG2226	methyltransferase
AWM71_RS05910	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AWM71_RS05920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AWM71_RS05925	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AWM71_RS05930	COG1216	Glycosyl transferase, family 2
AWM71_RS05945	COG1193	negative regulation of DNA recombination
AWM71_RS05950	COG3118	belongs to the thioredoxin family
AWM71_RS05960	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AWM71_RS05975	COG1131	(ABC) transporter
AWM71_RS05990	COG0668	transmembrane transport
AWM71_RS06000	COG4980	gas vesicle protein
AWM71_RS06020	COG3715	PTS system
AWM71_RS06035	COG0561	phosphatase activity
AWM71_RS06050	COG3579	cysteine-type endopeptidase activity
AWM71_RS06060	COG5503	Protein of unknown function (DUF1447)
AWM71_RS06065	COG4841	protein insertion into membrane
AWM71_RS06080	COG0628	permease
AWM71_RS06090	COG1132	(ABC) transporter
AWM71_RS06100	COG0488	(ABC) transporter
AWM71_RS06105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AWM71_RS06110	COG0352	thiamine-phosphate diphosphorylase activity
AWM71_RS06115	COG0546	phosphoglycolate phosphatase activity
AWM71_RS06120	COG0351	phosphomethylpyrimidine kinase
AWM71_RS06120	COG0352	thiamine-phosphate diphosphorylase activity
AWM71_RS06125	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AWM71_RS06130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM71_RS06140	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AWM71_RS06145	COG1122	ATPase activity
AWM71_RS06150	COG4721	ABC-type cobalt transport system, permease component
AWM71_RS06155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AWM71_RS06160	COG0561	phosphatase activity
AWM71_RS06165	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AWM71_RS06175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWM71_RS06180	COG3331	DNA recombination
AWM71_RS06185	COG0544	peptidyl-prolyl cis-trans isomerase activity
AWM71_RS06190	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AWM71_RS06200	COG0358	DNA primase activity
AWM71_RS06205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AWM71_RS06210	COG0527	aspartate kinase activity
AWM71_RS06235	COG1857	crispr-associated protein
AWM71_RS06250	COG1518	maintenance of DNA repeat elements
AWM71_RS06255	COG2176	DNA-directed DNA polymerase activity
AWM71_RS06290	COG1598	PFAM Uncharacterised protein family UPF0150
AWM71_RS06310	COG1028	Short-chain dehydrogenase reductase Sdr
AWM71_RS06320	COG2183	response to ionizing radiation
AWM71_RS06325	COG3091	SprT-like family
AWM71_RS06330	COG0583	DNA-binding transcription factor activity
AWM71_RS06335	COG0280	phosphate acetyltransferase
AWM71_RS06340	COG3426	butyrate kinase activity
AWM71_RS06345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWM71_RS06350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AWM71_RS06355	COG0022	dehydrogenase e1 component
AWM71_RS06360	COG0508	dehydrogenase complex catalyzes the overall conversion of
AWM71_RS06370	COG0765	amino acid transport
AWM71_RS06375	COG1126	abc transporter atp-binding protein
AWM71_RS06390	COG1792	Involved in formation and maintenance of cell shape
AWM71_RS06400	COG0765	amino acid transport
AWM71_RS06405	COG1126	abc transporter atp-binding protein
AWM71_RS06410	COG1028	Short-chain dehydrogenase reductase Sdr
AWM71_RS06425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AWM71_RS06430	COG0167	dihydroorotate dehydrogenase activity
AWM71_RS06435	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AWM71_RS06445	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AWM71_RS06470	COG2801	Transposase and inactivated derivatives
AWM71_RS06490	COG1132	(ABC) transporter
AWM71_RS06500	COG3842	ATPase activity
AWM71_RS06505	COG1176	ABC-type spermidine putrescine transport system, permease component I
AWM71_RS06510	COG1177	transmembrane transport
AWM71_RS06515	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AWM71_RS06520	COG1028	Short-chain dehydrogenase reductase Sdr
AWM71_RS06545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM71_RS06595	COG4152	abc transporter atp-binding protein
AWM71_RS06615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWM71_RS06620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM71_RS06625	COG1301	dicarboxylic acid transport
AWM71_RS06640	COG2022	thiamine diphosphate biosynthetic process
AWM71_RS06670	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AWM71_RS06675	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AWM71_RS06680	COG1447	Phosphotransferase system cellobiose-specific component IIA
AWM71_RS06700	COG0582	viral genome integration into host DNA
AWM71_RS06820	COG1349	DNA-binding transcription factor activity
AWM71_RS06835	COG0039	L-malate dehydrogenase activity
AWM71_RS06840	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AWM71_RS06845	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWM71_RS06855	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AWM71_RS06860	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AWM71_RS06865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AWM71_RS06880	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AWM71_RS06885	COG1104	cysteine desulfurase activity
AWM71_RS06900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AWM71_RS06910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AWM71_RS06920	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AWM71_RS06950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AWM71_RS06955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AWM71_RS06960	COG0052	Belongs to the universal ribosomal protein uS2 family
AWM71_RS06970	COG0528	UMP kinase activity
AWM71_RS06975	COG0233	cytoplasmic translational termination
AWM71_RS06980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AWM71_RS06985	COG4589	Belongs to the CDS family
AWM71_RS06990	COG0750	zinc metalloprotease
AWM71_RS07000	COG0779	Required for maturation of 30S ribosomal subunits
AWM71_RS07005	COG0195	Participates in both transcription termination and antitermination
AWM71_RS07010	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AWM71_RS07020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AWM71_RS07025	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AWM71_RS07050	COG3022	response to hydroperoxide
AWM71_RS07055	COG1028	Short-chain dehydrogenase reductase Sdr
AWM71_RS07075	COG1674	ftsk spoiiie
AWM71_RS07080	COG2946	Replication initiation factor
AWM71_RS07110	COG0741	lytic transglycosylase activity
AWM71_RS07110	COG0791	NLP P60 protein
AWM71_RS07150	COG4708	membrane
AWM71_RS07155	COG0514	ATP-dependent DNA helicase (RecQ)
AWM71_RS07160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AWM71_RS07165	COG0196	riboflavin kinase activity
AWM71_RS07190	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AWM71_RS07200	COG0484	heat shock protein binding
AWM71_RS07215	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AWM71_RS07220	COG0488	(ABC) transporter
AWM71_RS07225	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AWM71_RS07240	COG4479	Belongs to the UPF0346 family
AWM71_RS07245	COG3409	Peptidoglycan-binding domain 1 protein
AWM71_RS07245	COG0793	Belongs to the peptidase S41A family
AWM71_RS07255	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AWM71_RS07260	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AWM71_RS07265	COG0758	DNA mediated transformation
AWM71_RS07270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AWM71_RS07280	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AWM71_RS07285	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AWM71_RS07290	COG0187	DNA topoisomerase II activity
AWM71_RS07295	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWM71_RS07310	COG2205	protein histidine kinase activity
AWM71_RS07315	COG1136	(ABC) transporter
AWM71_RS07335	COG2610	gluconate transmembrane transporter activity
AWM71_RS07355	COG1754	DNA topoisomerase type I activity
AWM71_RS07355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AWM71_RS07385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWM71_RS07425	COG1028	Short-chain dehydrogenase reductase Sdr
AWM71_RS07430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AWM71_RS07435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWM71_RS07470	COG1136	(ABC) transporter
AWM71_RS07480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWM71_RS07485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AWM71_RS07485	COG1116	anion transmembrane transporter activity
AWM71_RS07505	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AWM71_RS07535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWM71_RS07560	COG0589	response to stress
AWM71_RS07565	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AWM71_RS07570	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AWM71_RS07575	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AWM71_RS07580	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AWM71_RS07585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AWM71_RS07590	COG2131	deaminase
AWM71_RS07600	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AWM71_RS07610	COG1668	transmembrane transport
AWM71_RS07615	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AWM71_RS07630	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AWM71_RS07630	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AWM71_RS07635	COG1234	tRNA 3'-trailer cleavage
AWM71_RS07645	COG0751	glycine-tRNA ligase activity
AWM71_RS07650	COG0752	glycyl-tRNA synthetase alpha subunit
AWM71_RS07655	COG1381	Involved in DNA repair and RecF pathway recombination
AWM71_RS07660	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AWM71_RS07670	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AWM71_RS07675	COG1702	phosphate starvation-inducible protein PhoH
AWM71_RS07680	COG1610	YqeY-like protein
AWM71_RS07685	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AWM71_RS07700	COG0735	belongs to the Fur family
AWM71_RS07705	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AWM71_RS07725	COG0616	signal peptide processing
AWM71_RS07730	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AWM71_RS07735	COG0124	histidyl-tRNA synthetase
AWM71_RS07745	COG1196	nuclear chromosome segregation
AWM71_RS07745	COG4372	Transposase
AWM71_RS07745	COG1511	domain protein
AWM71_RS07780	COG0157	Belongs to the NadC ModD family
AWM71_RS07805	COG0431	NADPH-dependent FMN reductase
AWM71_RS07805	COG1053	succinate dehydrogenase
AWM71_RS07805	COG3976	FMN-binding domain protein