locus-tag	class	description
AWM72_RS00015	COG0756	dUTP diphosphatase activity
AWM72_RS00110	COG1396	sequence-specific DNA binding
AWM72_RS00145	COG0582	viral genome integration into host DNA
AWM72_RS00160	COG1598	PFAM Uncharacterised protein family UPF0150
AWM72_RS00170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWM72_RS00200	COG0604	alcohol dehydrogenase
AWM72_RS00235	COG0366	Alpha amylase catalytic
AWM72_RS00250	COG0018	arginyl-trna synthetase
AWM72_RS00255	COG0549	Belongs to the carbamate kinase family
AWM72_RS00260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM72_RS00265	COG1288	antiporter activity
AWM72_RS00275	COG2235	arginine
AWM72_RS00285	COG1288	antiporter activity
AWM72_RS00305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AWM72_RS00310	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AWM72_RS00315	COG0009	L-threonylcarbamoyladenylate synthase
AWM72_RS00320	COG2890	protein-(glutamine-N5) methyltransferase activity
AWM72_RS00325	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AWM72_RS00330	COG1435	thymidine kinase activity
AWM72_RS00335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AWM72_RS00340	COG3442	glutamine amidotransferase
AWM72_RS00345	COG0628	permease
AWM72_RS00350	COG2706	6-phosphogluconolactonase activity
AWM72_RS00355	COG1968	undecaprenyl-diphosphatase activity
AWM72_RS00360	COG0527	aspartate kinase activity
AWM72_RS00365	COG1473	amidohydrolase
AWM72_RS00375	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AWM72_RS00380	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AWM72_RS00385	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AWM72_RS00390	COG0346	lactoylglutathione lyase activity
AWM72_RS00410	COG2183	response to ionizing radiation
AWM72_RS00430	COG0018	arginyl-trna synthetase
AWM72_RS00435	COG3590	peptidase
AWM72_RS00455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AWM72_RS00470	COG0719	Fe-S assembly protein
AWM72_RS00480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AWM72_RS00485	COG0719	Fe-S assembly protein
AWM72_RS00505	COG0183	Belongs to the thiolase family
AWM72_RS00520	COG0772	Belongs to the SEDS family
AWM72_RS00535	COG1464	Belongs to the NlpA lipoprotein family
AWM72_RS00540	COG1902	pentaerythritol trinitrate reductase activity
AWM72_RS00550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AWM72_RS00555	COG1307	EDD domain protein, DegV family
AWM72_RS00565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AWM72_RS00570	COG0358	DNA primase activity
AWM72_RS00575	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AWM72_RS00580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AWM72_RS00590	COG3331	DNA recombination
AWM72_RS00595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWM72_RS00615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AWM72_RS00620	COG0561	phosphatase activity
AWM72_RS00625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AWM72_RS00630	COG4475	Protein of unknown function (DUF436)
AWM72_RS00640	COG0584	glycerophosphoryl diester phosphodiesterase
AWM72_RS00650	COG0395	ABC-type sugar transport system, permease component
AWM72_RS00665	COG0248	Ppx GppA phosphatase
AWM72_RS00670	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AWM72_RS00675	COG0488	(ABC) transporter
AWM72_RS00690	COG1160	GTP binding
AWM72_RS00695	COG1272	protein, Hemolysin III
AWM72_RS00705	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AWM72_RS00710	COG2197	response regulator
AWM72_RS00715	COG4585	Histidine kinase
AWM72_RS00725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AWM72_RS00730	COG0572	uridine kinase
AWM72_RS00735	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AWM72_RS00745	COG3906	Belongs to the UPF0473 family
AWM72_RS00760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AWM72_RS00765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AWM72_RS00770	COG0482	sulfurtransferase activity
AWM72_RS00785	COG1104	cysteine desulfurase activity
AWM72_RS00795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AWM72_RS00810	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AWM72_RS00815	COG0827	DNA restriction-modification system
AWM72_RS00820	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AWM72_RS00825	COG2868	ribosomal protein
AWM72_RS00830	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AWM72_RS00870	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AWM72_RS00875	COG0511	ligase activity, forming carbon-carbon bonds
AWM72_RS00885	COG2851	Citrate transporter
AWM72_RS00890	COG2190	(PTS) system
AWM72_RS00890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM72_RS00890	COG1263	PTS System
AWM72_RS00895	COG1126	abc transporter atp-binding protein
AWM72_RS00900	COG0765	amino acid transport
AWM72_RS01045	COG0166	Belongs to the GPI family
AWM72_RS01050	COG1098	S1 RNA binding domain
AWM72_RS01055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AWM72_RS01060	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AWM72_RS01080	COG4470	Protein conserved in bacteria
AWM72_RS01100	COG5353	protein conserved in bacteria
AWM72_RS01115	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AWM72_RS01130	COG1160	GTP binding
AWM72_RS01135	COG0539	negative regulation of cytoplasmic translation
AWM72_RS01145	COG1388	LysM domain
AWM72_RS01145	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM72_RS01150	COG0514	ATP-dependent DNA helicase (RecQ)
AWM72_RS01165	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AWM72_RS01170	COG1187	pseudouridine synthase activity
AWM72_RS01175	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AWM72_RS01180	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AWM72_RS01190	COG1442	glycosyl transferase family 8
AWM72_RS01200	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AWM72_RS01215	COG0735	belongs to the Fur family
AWM72_RS01220	COG2996	Protein conserved in bacteria
AWM72_RS01230	COG0205	6-phosphofructokinase activity
AWM72_RS01235	COG0587	DNA-directed DNA polymerase activity
AWM72_RS01240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AWM72_RS01245	COG2255	four-way junction helicase activity
AWM72_RS01250	COG0632	four-way junction helicase activity
AWM72_RS01255	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AWM72_RS01265	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AWM72_RS01295	COG3527	Alpha-acetolactate decarboxylase
AWM72_RS01305	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AWM72_RS01310	COG1058	Belongs to the CinA family
AWM72_RS01310	COG1546	Belongs to the CinA family
AWM72_RS01315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AWM72_RS01320	COG4980	gas vesicle protein
AWM72_RS01320	COG1674	ftsk spoiiie
AWM72_RS01325	COG1254	Belongs to the acylphosphatase family
AWM72_RS01330	COG0706	membrane insertase activity
AWM72_RS01335	COG5002	protein histidine kinase activity
AWM72_RS01340	COG0745	RESPONSE REGULATOR receiver
AWM72_RS01345	COG0301	tRNA thio-modification
AWM72_RS01350	COG1104	cysteine desulfurase activity
AWM72_RS01355	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AWM72_RS01360	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AWM72_RS01385	COG3853	Toxic anion resistance protein (TelA)
AWM72_RS01400	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AWM72_RS01405	COG3599	regulation of cell shape
AWM72_RS01410	COG2302	S4 RNA-binding domain
AWM72_RS01420	COG1799	cell septum assembly
AWM72_RS01425	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AWM72_RS01430	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AWM72_RS01435	COG0849	cell division
AWM72_RS01440	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AWM72_RS01445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AWM72_RS01455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AWM72_RS01460	COG0768	penicillin binding
AWM72_RS01475	COG2001	Belongs to the MraZ family
AWM72_RS01490	COG1323	Belongs to the UPF0348 family
AWM72_RS01495	COG2226	methyltransferase
AWM72_RS01500	COG0799	negative regulation of ribosome biogenesis
AWM72_RS01505	COG1713	HD superfamily hydrolase involved in NAD metabolism
AWM72_RS01510	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AWM72_RS01515	COG1534	Rna-binding protein
AWM72_RS01520	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AWM72_RS01540	COG0542	response to heat
AWM72_RS01550	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AWM72_RS01565	COG0252	asparaginase activity
AWM72_RS01595	COG0066	3-isopropylmalate dehydratase activity
AWM72_RS01610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AWM72_RS01615	COG2084	Dehydrogenase
AWM72_RS01630	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AWM72_RS01645	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWM72_RS01655	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AWM72_RS01660	COG1461	Dihydroxyacetone kinase
AWM72_RS01665	COG2376	Dihydroxyacetone kinase
AWM72_RS01675	COG0335	large ribosomal subunit rRNA binding
AWM72_RS01680	COG1011	Hydrolase
AWM72_RS01685	COG0149	triose-phosphate isomerase activity
AWM72_RS01700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AWM72_RS01705	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AWM72_RS01735	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AWM72_RS01740	COG1837	Belongs to the UPF0109 family
AWM72_RS01745	COG0228	four-way junction DNA binding
AWM72_RS01750	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AWM72_RS01755	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AWM72_RS01760	COG0552	protein localization to endoplasmic reticulum
AWM72_RS01765	COG0561	phosphatase activity
AWM72_RS01770	COG1196	nuclear chromosome segregation
AWM72_RS01775	COG0571	ribonuclease III activity
AWM72_RS01780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AWM72_RS01790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AWM72_RS01795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM72_RS01805	COG1302	Protein conserved in bacteria
AWM72_RS01810	COG2217	Heavy metal translocating P-type atpase
AWM72_RS01815	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AWM72_RS01825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AWM72_RS01830	COG1162	GTPase activity
AWM72_RS01835	COG0515	serine threonine protein kinase
AWM72_RS01835	COG2815	serine threonine protein kinase
AWM72_RS01845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWM72_RS01845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AWM72_RS01850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AWM72_RS01855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AWM72_RS01860	COG1758	RNA polymerase activity
AWM72_RS01865	COG0194	GDP metabolic process
AWM72_RS01890	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AWM72_RS01905	COG1185	polyribonucleotide nucleotidyltransferase activity
AWM72_RS01910	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AWM72_RS01915	COG1307	EDD domain protein, DegV family
AWM72_RS01920	COG0671	phosphoesterase, PA-phosphatase related
AWM72_RS01925	COG0556	nucleotide-excision repair
AWM72_RS01940	COG1466	dna polymerase III delta subunit
AWM72_RS01950	COG1596	polysaccharide export
AWM72_RS01950	COG1555	photosystem II stabilization
AWM72_RS01955	COG0742	ribosomal rna small subunit methyltransferase
AWM72_RS01960	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AWM72_RS02040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWM72_RS02070	COG4471	UPF0298 protein
AWM72_RS02075	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AWM72_RS02080	COG0772	Belongs to the SEDS family
AWM72_RS02085	COG4838	Belongs to the UPF0358 family
AWM72_RS02090	COG1217	gtp-binding protein TYPA
AWM72_RS02095	COG0483	inositol monophosphate 1-phosphatase activity
AWM72_RS02115	COG0022	dehydrogenase e1 component
AWM72_RS02125	COG0242	peptide deformylase activity
AWM72_RS02130	COG1028	Short-chain dehydrogenase reductase Sdr
AWM72_RS02140	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AWM72_RS02150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AWM72_RS02160	COG0440	acetolactate synthase activity
AWM72_RS02165	COG0028	Belongs to the TPP enzyme family
AWM72_RS02170	COG1119	ATPase activity
AWM72_RS02175	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AWM72_RS02195	COG3425	synthase
AWM72_RS02210	COG1904	glucuronate isomerase
AWM72_RS02220	COG0800	Aldolase
AWM72_RS02230	COG1028	Short-chain dehydrogenase reductase Sdr
AWM72_RS02240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM72_RS02250	COG0006	proline dipeptidase activity
AWM72_RS02260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AWM72_RS02265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AWM72_RS02285	COG1028	Short-chain dehydrogenase reductase Sdr
AWM72_RS02305	COG1876	peptidase activity
AWM72_RS02310	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AWM72_RS02315	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AWM72_RS02320	COG0385	Bile acid
AWM72_RS02340	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AWM72_RS02340	COG0512	Glutamine amidotransferase of anthranilate synthase
AWM72_RS02370	COG1136	(ABC) transporter
AWM72_RS02375	COG1309	transcriptional regulator
AWM72_RS02385	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AWM72_RS02390	COG0583	DNA-binding transcription factor activity
AWM72_RS02415	COG1054	Belongs to the UPF0176 family
AWM72_RS02450	COG0745	RESPONSE REGULATOR receiver
AWM72_RS02495	COG1215	transferase activity, transferring glycosyl groups
AWM72_RS02505	COG3307	-O-antigen
AWM72_RS02510	COG0438	transferase activity, transferring glycosyl groups
AWM72_RS02520	COG0438	transferase activity, transferring glycosyl groups
AWM72_RS02545	COG1028	Short-chain dehydrogenase reductase Sdr
AWM72_RS02550	COG0583	DNA-binding transcription factor activity
AWM72_RS02570	COG0488	(ABC) transporter
AWM72_RS02610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AWM72_RS02630	COG0656	L-ascorbic acid biosynthetic process
AWM72_RS02695	COG0765	amino acid transport
AWM72_RS02700	COG0653	protein targeting
AWM72_RS02715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWM72_RS02720	COG1121	(ABC) transporter
AWM72_RS02725	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWM72_RS02725	COG3443	Belongs to the bacterial solute-binding protein 9 family
AWM72_RS02730	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AWM72_RS02735	COG4466	Protein conserved in bacteria
AWM72_RS02740	COG1794	racemase activity, acting on amino acids and derivatives
AWM72_RS02750	COG0367	asparagine synthase
AWM72_RS02755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AWM72_RS02760	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AWM72_RS02765	COG0084	hydrolase, TatD family'
AWM72_RS02770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM72_RS02770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM72_RS02785	COG0436	Aminotransferase
AWM72_RS02800	COG0174	glutamine synthetase
AWM72_RS02810	COG2738	Putative neutral zinc metallopeptidase
AWM72_RS02830	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AWM72_RS02835	COG0509	glycine decarboxylation via glycine cleavage system
AWM72_RS02840	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AWM72_RS02845	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AWM72_RS02855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWM72_RS02860	COG1321	iron dependent repressor
AWM72_RS02860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWM72_RS02865	COG1121	(ABC) transporter
AWM72_RS02870	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWM72_RS02885	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AWM72_RS02890	COG0564	pseudouridine synthase activity
AWM72_RS02895	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AWM72_RS02905	COG4708	membrane
AWM72_RS02920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AWM72_RS02935	COG1473	amidohydrolase
AWM72_RS02945	COG1464	Belongs to the NlpA lipoprotein family
AWM72_RS02955	COG3949	Membrane
AWM72_RS02995	COG3119	arylsulfatase activity
AWM72_RS03010	COG1597	lipid kinase activity
AWM72_RS03015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AWM72_RS03020	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AWM72_RS03035	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWM72_RS03040	COG0101	tRNA pseudouridine synthase activity
AWM72_RS03050	COG1122	ATPase activity
AWM72_RS03055	COG1122	ATPase activity
AWM72_RS03060	COG2755	lipolytic protein G-D-S-L family
AWM72_RS03060	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AWM72_RS03065	COG0203	ribosomal protein L17
AWM72_RS03070	COG0202	RNA polymerase activity
AWM72_RS03075	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AWM72_RS03080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AWM72_RS03085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AWM72_RS03090	COG0563	adenylate kinase activity
AWM72_RS03110	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AWM72_RS03115	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AWM72_RS03120	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AWM72_RS03125	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AWM72_RS03130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AWM72_RS03135	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AWM72_RS03140	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AWM72_RS03145	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AWM72_RS03150	COG0255	Belongs to the universal ribosomal protein uL29 family
AWM72_RS03155	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AWM72_RS03160	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AWM72_RS03165	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AWM72_RS03170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AWM72_RS03175	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AWM72_RS03180	COG0089	rRNA binding
AWM72_RS03190	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AWM72_RS03195	COG0051	transcription antitermination factor activity, RNA binding
AWM72_RS03200	COG0431	NADPH-dependent FMN reductase
AWM72_RS03200	COG1053	succinate dehydrogenase
AWM72_RS03200	COG3976	FMN-binding domain protein
AWM72_RS03205	COG0431	NADPH-dependent FMN reductase
AWM72_RS03205	COG1053	succinate dehydrogenase
AWM72_RS03205	COG3976	FMN-binding domain protein
AWM72_RS03225	COG0588	phosphoglycerate mutase activity
AWM72_RS03235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AWM72_RS03240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AWM72_RS03245	COG0049	tRNA binding
AWM72_RS03250	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AWM72_RS03255	COG0860	N-Acetylmuramoyl-L-alanine amidase
AWM72_RS03270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AWM72_RS03275	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AWM72_RS03285	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AWM72_RS03290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AWM72_RS03295	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AWM72_RS03300	COG0037	tRNA processing
AWM72_RS03305	COG1098	S1 RNA binding domain
AWM72_RS03315	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AWM72_RS03320	COG2244	polysaccharide biosynthetic process
AWM72_RS03325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AWM72_RS03330	COG0193	aminoacyl-tRNA hydrolase activity
AWM72_RS03335	COG0039	L-malate dehydrogenase activity
AWM72_RS03345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AWM72_RS03350	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AWM72_RS03355	COG0513	Belongs to the DEAD box helicase family
AWM72_RS03405	COG0463	Glycosyl transferase, family 2
AWM72_RS03445	COG4122	O-methyltransferase activity
AWM72_RS03450	COG1253	flavin adenine dinucleotide binding
AWM72_RS03470	COG1126	abc transporter atp-binding protein
AWM72_RS03475	COG0765	amino acid transport
AWM72_RS03480	COG0765	amino acid transport
AWM72_RS03490	COG2151	metal-sulfur cluster biosynthetic enzyme
AWM72_RS03505	COG1482	cell wall glycoprotein biosynthetic process
AWM72_RS03515	COG3716	PTS system mannose fructose sorbose family IID component
AWM72_RS03520	COG3715	PTS system
AWM72_RS03545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM72_RS03570	COG2217	Heavy metal translocating P-type atpase
AWM72_RS03575	COG1028	Short-chain dehydrogenase reductase Sdr
AWM72_RS03590	COG0561	phosphatase activity
AWM72_RS03595	COG1362	aminopeptidase activity
AWM72_RS03620	COG1940	carbohydrate kinase activity
AWM72_RS03630	COG1131	(ABC) transporter
AWM72_RS03640	COG1464	Belongs to the NlpA lipoprotein family
AWM72_RS03645	COG2610	gluconate transmembrane transporter activity
AWM72_RS03650	COG3395	kinase activity
AWM72_RS03665	COG4536	flavin adenine dinucleotide binding
AWM72_RS03680	COG1132	(ABC) transporter
AWM72_RS03685	COG1132	(ABC) transporter
AWM72_RS03690	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AWM72_RS03695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AWM72_RS03695	COG0574	Belongs to the PEP-utilizing enzyme family
AWM72_RS03700	COG1187	pseudouridine synthase activity
AWM72_RS03705	COG1073	alpha beta
AWM72_RS03710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AWM72_RS03715	COG4956	integral membrane protein (PIN domain superfamily)
AWM72_RS03720	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AWM72_RS03725	COG0756	dUTP diphosphatase activity
AWM72_RS03730	COG0737	Belongs to the 5'-nucleotidase family
AWM72_RS03745	COG0157	Belongs to the NadC ModD family
AWM72_RS03765	COG0628	permease
AWM72_RS03775	COG0789	Transcriptional regulator
AWM72_RS03780	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AWM72_RS03785	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AWM72_RS03795	COG0438	transferase activity, transferring glycosyl groups
AWM72_RS03800	COG0129	dihydroxy-acid dehydratase activity
AWM72_RS03810	COG0366	Alpha amylase catalytic
AWM72_RS03815	COG1263	PTS System
AWM72_RS03815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM72_RS03840	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AWM72_RS03890	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AWM72_RS03895	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AWM72_RS03905	COG0138	bifunctional purine biosynthesis protein purh
AWM72_RS03910	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AWM72_RS03915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AWM72_RS03925	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AWM72_RS03935	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AWM72_RS03940	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AWM72_RS03945	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AWM72_RS03950	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AWM72_RS03960	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AWM72_RS03965	COG2239	Acts as a magnesium transporter
AWM72_RS03970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWM72_RS03995	COG1473	amidohydrolase
AWM72_RS04010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AWM72_RS04040	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AWM72_RS04045	COG0305	Participates in initiation and elongation during chromosome replication
AWM72_RS04050	COG0359	binds to the 23S rRNA
AWM72_RS04060	COG0629	single-stranded DNA binding
AWM72_RS04065	COG0360	Binds together with S18 to 16S ribosomal RNA
AWM72_RS04090	COG1304	FMN binding
AWM72_RS04095	COG4152	abc transporter atp-binding protein
AWM72_RS04100	COG1668	transmembrane transport
AWM72_RS04105	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWM72_RS04110	COG0187	DNA topoisomerase II activity
AWM72_RS04115	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AWM72_RS04120	COG2501	S4 domain
AWM72_RS04135	COG0592	DNA-directed DNA polymerase activity
AWM72_RS04150	COG0706	membrane insertase activity
AWM72_RS04155	COG1847	R3H domain protein
AWM72_RS04160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AWM72_RS04160	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AWM72_RS04180	COG3842	ATPase activity
AWM72_RS04185	COG1349	DNA-binding transcription factor activity
AWM72_RS04190	COG0561	phosphatase activity
AWM72_RS04195	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AWM72_RS04200	COG0445	tRNA wobble uridine modification
AWM72_RS04230	COG2514	catechol 2,3-dioxygenase activity
AWM72_RS04240	COG1192	Involved in chromosome partitioning
AWM72_RS04245	COG1475	DNA binding
AWM72_RS04250	COG4481	Protein conserved in bacteria
AWM72_RS04255	COG0012	GTP binding
AWM72_RS04270	COG0516	GMP reductase activity
AWM72_RS04270	COG0517	IMP dehydrogenase activity
AWM72_RS04275	COG0693	protein deglycase activity
AWM72_RS04295	COG1686	Belongs to the peptidase S11 family
AWM72_RS04300	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AWM72_RS04305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AWM72_RS04350	COG0626	cystathionine gamma-synthase activity
AWM72_RS04360	COG1131	(ABC) transporter
AWM72_RS04365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWM72_RS04390	COG0589	response to stress
AWM72_RS04410	COG1302	Protein conserved in bacteria
AWM72_RS04415	COG0693	protein deglycase activity
AWM72_RS04420	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AWM72_RS04425	COG1132	(ABC) transporter
AWM72_RS04430	COG1132	(ABC) transporter
AWM72_RS04435	COG0826	peptidase U32
AWM72_RS04440	COG0826	peptidase U32
AWM72_RS04450	COG2814	Major facilitator Superfamily
AWM72_RS04460	COG0284	orotidine-5'-phosphate decarboxylase activity
AWM72_RS04515	COG3279	Response regulator of the LytR AlgR family
AWM72_RS04535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWM72_RS04545	COG0393	Putative heavy-metal-binding
AWM72_RS04550	COG2226	methyltransferase
AWM72_RS04555	COG3189	MarR family transcriptional regulator
AWM72_RS04570	COG2252	PERMEase
AWM72_RS04585	COG0561	phosphatase activity
AWM72_RS04590	COG0494	nUDIX hydrolase
AWM72_RS04600	COG1607	acyl-coa hydrolase
AWM72_RS04605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AWM72_RS04630	COG0473	3-isopropylmalate dehydrogenase activity
AWM72_RS04635	COG0628	permease
AWM72_RS04640	COG3579	cysteine-type endopeptidase activity
AWM72_RS04670	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AWM72_RS04675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWM72_RS04710	COG1388	LysM domain
AWM72_RS04710	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM72_RS04715	COG1388	LysM domain
AWM72_RS04715	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM72_RS04720	COG1695	Transcriptional regulator
AWM72_RS04740	COG0250	Participates in transcription elongation, termination and antitermination
AWM72_RS04750	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWM72_RS04765	COG0081	regulation of translation
AWM72_RS04780	COG1811	Na channel or pump
AWM72_RS04785	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AWM72_RS04790	COG0222	ribosome binding
AWM72_RS04805	COG0133	tryptophan synthase activity
AWM72_RS04810	COG0135	phosphoribosylanthranilate isomerase activity
AWM72_RS04815	COG0134	indole-3-glycerol-phosphate synthase activity
AWM72_RS04820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AWM72_RS04835	COG1064	alcohol dehydrogenase
AWM72_RS04845	COG2813	Specifically methylates the guanine in position
AWM72_RS04850	COG0778	Nitroreductase
AWM72_RS04855	COG0085	RNA polymerase activity
AWM72_RS04860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AWM72_RS04870	COG4619	ABC transporter
AWM72_RS04875	COG0390	transport system, permease component
AWM72_RS04915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AWM72_RS04925	COG4463	regulation of RNA biosynthetic process
AWM72_RS04940	COG0039	L-malate dehydrogenase activity
AWM72_RS04950	COG0590	tRNA wobble adenosine to inosine editing
AWM72_RS04960	COG1269	ATP hydrolysis coupled proton transport
AWM72_RS04965	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AWM72_RS04975	COG1527	subunit (C
AWM72_RS04980	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
AWM72_RS04985	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AWM72_RS04990	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
AWM72_RS04995	COG1394	ATPase activity, coupled to movement of substances
AWM72_RS05015	COG1191	sigma factor activity
AWM72_RS05030	COG2610	gluconate transmembrane transporter activity
AWM72_RS05035	COG1929	Belongs to the glycerate kinase type-1 family
AWM72_RS05045	COG0431	NADPH-dependent FMN reductase
AWM72_RS05045	COG3976	FMN-binding domain protein
AWM72_RS05045	COG1053	succinate dehydrogenase
AWM72_RS05050	COG2610	gluconate transmembrane transporter activity
AWM72_RS05075	COG2865	translation initiation factor activity
AWM72_RS05100	COG0747	negative chemotaxis
AWM72_RS05105	COG0601	transmembrane transport
AWM72_RS05110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWM72_RS05115	COG0444	Belongs to the ABC transporter superfamily
AWM72_RS05120	COG4608	Belongs to the ABC transporter superfamily
AWM72_RS05125	COG3443	Belongs to the bacterial solute-binding protein 9 family
AWM72_RS05125	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWM72_RS05130	COG1464	Belongs to the NlpA lipoprotein family
AWM72_RS05150	COG0392	lysyltransferase activity
AWM72_RS05150	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AWM72_RS05165	COG2873	o-acetylhomoserine
AWM72_RS05170	COG1028	Short-chain dehydrogenase reductase Sdr
AWM72_RS05175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWM72_RS05185	COG1328	CTP reductase activity
AWM72_RS05195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AWM72_RS05200	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AWM72_RS05205	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AWM72_RS05210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AWM72_RS05215	COG0470	DNA polymerase III
AWM72_RS05225	COG4467	Involved in initiation control of chromosome replication
AWM72_RS05230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AWM72_RS05235	COG2827	Endonuclease containing a URI domain
AWM72_RS05240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AWM72_RS05250	COG1970	mechanosensitive ion channel activity
AWM72_RS05255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWM72_RS05270	COG2211	Major facilitator Superfamily
AWM72_RS05275	COG0697	spore germination
AWM72_RS05280	COG1078	dGTPase activity
AWM72_RS05295	COG3343	RNA polymerase activity
AWM72_RS05300	COG0504	CTP synthase activity
AWM72_RS05305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AWM72_RS05310	COG0254	rRNA binding
AWM72_RS05315	COG0583	DNA-binding transcription factor activity
AWM72_RS05320	COG0583	DNA-binding transcription factor activity
AWM72_RS05325	COG3764	Sortase (surface protein transpeptidase)
AWM72_RS05340	COG1181	Belongs to the D-alanine--D-alanine ligase family
AWM72_RS05345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AWM72_RS05380	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AWM72_RS05395	COG2211	Major facilitator Superfamily
AWM72_RS05400	COG2211	Major facilitator Superfamily
AWM72_RS05405	COG4224	UPF0291 protein
AWM72_RS05415	COG0577	efflux transmembrane transporter activity
AWM72_RS05415	COG1136	(ABC) transporter
AWM72_RS05420	COG1136	(ABC) transporter
AWM72_RS05420	COG0577	efflux transmembrane transporter activity
AWM72_RS05425	COG1214	PFAM Peptidase M22, glycoprotease
AWM72_RS05440	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AWM72_RS05445	COG0488	(ABC) transporter
AWM72_RS05455	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AWM72_RS05470	COG0459	protein refolding
AWM72_RS05475	COG0431	NADPH-dependent FMN reductase
AWM72_RS05480	COG1012	belongs to the aldehyde dehydrogenase family
AWM72_RS05485	COG0165	Argininosuccinate lyase
AWM72_RS05495	COG0765	amino acid transport
AWM72_RS05505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AWM72_RS05510	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AWM72_RS05515	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AWM72_RS05525	COG3279	Response regulator of the LytR AlgR family
AWM72_RS05530	COG0058	SHG alpha-glucan phosphorylase activity
AWM72_RS05535	COG1640	4-alpha-glucanotransferase
AWM72_RS05540	COG1609	Transcriptional regulator
AWM72_RS05545	COG1263	PTS System
AWM72_RS05545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM72_RS05545	COG2190	(PTS) system
AWM72_RS05555	COG0698	ribose 5-phosphate isomerase
AWM72_RS05565	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWM72_RS05595	COG1857	crispr-associated protein
AWM72_RS05610	COG1518	maintenance of DNA repeat elements
AWM72_RS05615	COG2176	DNA-directed DNA polymerase activity
AWM72_RS05630	COG2309	aminopeptidase activity
AWM72_RS05635	COG0716	FMN binding
AWM72_RS05645	COG0024	Methionine aminopeptidase
AWM72_RS05655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWM72_RS05665	COG1263	PTS System
AWM72_RS05665	COG2190	(PTS) system
AWM72_RS05665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM72_RS05670	COG1739	Uncharacterized protein family UPF0029
AWM72_RS05675	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AWM72_RS05690	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AWM72_RS05695	COG0745	RESPONSE REGULATOR receiver
AWM72_RS05700	COG5002	protein histidine kinase activity
AWM72_RS05705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AWM72_RS05710	COG0573	inorganic phosphate transmembrane transporter activity
AWM72_RS05715	COG0581	inorganic phosphate transmembrane transporter activity
AWM72_RS05720	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AWM72_RS05730	COG0420	3'-5' exonuclease activity
AWM72_RS05750	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AWM72_RS05770	COG0492	ferredoxin-NADP+ reductase activity
AWM72_RS05780	COG1307	EDD domain protein, DegV family
AWM72_RS05785	COG1051	belongs to the nudix hydrolase family
AWM72_RS05795	COG3944	biosynthesis protein
AWM72_RS05800	COG0489	protein tyrosine kinase activity
AWM72_RS05805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWM72_RS05810	COG1660	Displays ATPase and GTPase activities
AWM72_RS05815	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AWM72_RS05820	COG1481	regulation of sporulation
AWM72_RS05830	COG4864	UPF0365 protein
AWM72_RS05840	COG0516	GMP reductase activity
AWM72_RS05850	COG0629	single-stranded DNA binding
AWM72_RS05855	COG0745	RESPONSE REGULATOR receiver
AWM72_RS05860	COG5002	protein histidine kinase activity
AWM72_RS05860	COG3850	Histidine kinase
AWM72_RS05865	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AWM72_RS05870	COG2081	HI0933 family
AWM72_RS05910	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM72_RS05925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AWM72_RS05940	COG0154	amidase activity
AWM72_RS05945	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AWM72_RS05950	COG3949	Membrane
AWM72_RS05960	COG0708	Exodeoxyribonuclease III
AWM72_RS05970	COG0745	RESPONSE REGULATOR receiver
AWM72_RS05975	COG5002	protein histidine kinase activity
AWM72_RS05985	COG4853	Protein conserved in bacteria
AWM72_RS05995	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AWM72_RS06000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AWM72_RS06010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AWM72_RS06015	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AWM72_RS06025	COG0726	polysaccharide deacetylase
AWM72_RS06030	COG1522	sequence-specific DNA binding
AWM72_RS06035	COG0436	Aminotransferase
AWM72_RS06055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AWM72_RS06065	COG0616	signal peptide processing
AWM72_RS06070	COG1131	(ABC) transporter
AWM72_RS06105	COG1131	(ABC) transporter
AWM72_RS06120	COG0745	RESPONSE REGULATOR receiver
AWM72_RS06130	COG1136	(ABC) transporter
AWM72_RS06150	COG0656	L-ascorbic acid biosynthetic process
AWM72_RS06160	COG0191	fructose-bisphosphate aldolase activity
AWM72_RS06165	COG3485	protocatechuate 3,4-dioxygenase
AWM72_RS06170	COG3485	protocatechuate 3,4-dioxygenase
AWM72_RS06175	COG3022	response to hydroperoxide
AWM72_RS06190	COG1918	ferrous iron import across plasma membrane
AWM72_RS06190	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AWM72_RS06205	COG1114	Component of the transport system for branched-chain amino acids
AWM72_RS06210	COG0386	Belongs to the glutathione peroxidase family
AWM72_RS06215	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AWM72_RS06235	COG0471	metal ion transport
AWM72_RS06240	COG2326	polyphosphate kinase activity
AWM72_RS06245	COG3448	diguanylate cyclase activity
AWM72_RS06245	COG4175	Glycine betaine
AWM72_RS06285	COG2964	Protein conserved in bacteria
AWM72_RS06305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM72_RS06305	COG3711	transcriptional antiterminator
AWM72_RS06315	COG1902	pentaerythritol trinitrate reductase activity
AWM72_RS06320	COG0583	DNA-binding transcription factor activity
AWM72_RS06340	COG3041	Addiction module toxin RelE StbE family
AWM72_RS06345	COG0582	viral genome integration into host DNA
AWM72_RS06410	COG0402	S-adenosylhomocysteine deaminase activity
AWM72_RS06415	COG2814	Major facilitator Superfamily
AWM72_RS06420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AWM72_RS06435	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AWM72_RS06445	COG2062	phosphohistidine phosphatase, SixA
AWM72_RS06450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AWM72_RS06460	COG5012	cobalamin binding
AWM72_RS06470	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AWM72_RS06480	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AWM72_RS06485	COG2321	neutral zinc metallopeptidase
AWM72_RS06495	COG1760	l-serine dehydratase
AWM72_RS06500	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AWM72_RS06505	COG2040	homocysteine
AWM72_RS06515	COG0514	ATP-dependent DNA helicase (RecQ)
AWM72_RS06520	COG0435	Glutathione S-transferase
AWM72_RS06525	COG0765	amino acid transport
AWM72_RS06530	COG0765	amino acid transport
AWM72_RS06535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWM72_RS06540	COG1126	abc transporter atp-binding protein
AWM72_RS06560	COG2137	regulation of response to DNA damage stimulus
AWM72_RS06565	COG1194	a g-specific adenine glycosylase
AWM72_RS06580	COG1523	belongs to the glycosyl hydrolase 13 family
AWM72_RS06590	COG0735	belongs to the Fur family
AWM72_RS06595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AWM72_RS06690	COG0516	GMP reductase activity
AWM72_RS06705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWM72_RS06710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWM72_RS06715	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AWM72_RS06720	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AWM72_RS06725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWM72_RS06730	COG3679	Belongs to the UPF0342 family
AWM72_RS06735	COG0420	3'-5' exonuclease activity
AWM72_RS06740	COG4717	serine-type aminopeptidase activity
AWM72_RS06745	COG3481	metal-dependent phosphohydrolase, HD sub domain
AWM72_RS06755	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AWM72_RS06770	COG0537	adenosine 5'-monophosphoramidase activity
AWM72_RS06775	COG1131	(ABC) transporter
AWM72_RS06785	COG0510	thiamine kinase activity
AWM72_RS06800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM72_RS06810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AWM72_RS06840	COG0285	dihydrofolate synthase activity
AWM72_RS06850	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AWM72_RS06855	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AWM72_RS06870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWM72_RS06870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWM72_RS06875	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AWM72_RS06880	COG0237	dephospho-CoA kinase activity
AWM72_RS06885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AWM72_RS06895	COG1484	DNA-dependent DNA replication
AWM72_RS06905	COG1302	Protein conserved in bacteria
AWM72_RS06910	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AWM72_RS06930	COG1464	Belongs to the NlpA lipoprotein family
AWM72_RS06935	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AWM72_RS06955	COG1115	amino acid carrier protein
AWM72_RS06960	COG3944	biosynthesis protein
AWM72_RS06965	COG0489	protein tyrosine kinase activity
AWM72_RS06975	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AWM72_RS06990	COG1086	Polysaccharide biosynthesis protein
AWM72_RS07015	COG1216	Glycosyl transferase, family 2
AWM72_RS07015	COG1442	glycosyl transferase family 8
AWM72_RS07020	COG1216	Glycosyl transferase, family 2
AWM72_RS07030	COG2244	polysaccharide biosynthetic process
AWM72_RS07105	COG1263	PTS System
AWM72_RS07105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM72_RS07105	COG2190	(PTS) system
AWM72_RS07110	COG2972	Histidine kinase
AWM72_RS07115	COG4753	response regulator
AWM72_RS07115	COG2207	Transcriptional regulator
AWM72_RS07135	COG0307	riboflavin synthase, alpha
AWM72_RS07150	COG0431	NADPH-dependent FMN reductase
AWM72_RS07150	COG1053	succinate dehydrogenase
AWM72_RS07150	COG3976	FMN-binding domain protein
AWM72_RS07155	COG0786	glutamate:sodium symporter activity
AWM72_RS07165	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AWM72_RS07165	COG3264	Mechanosensitive ion channel
AWM72_RS07180	COG1028	Short-chain dehydrogenase reductase Sdr
AWM72_RS07205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AWM72_RS07210	COG1028	Short-chain dehydrogenase reductase Sdr
AWM72_RS07215	COG4720	Psort location CytoplasmicMembrane, score
AWM72_RS07225	COG0110	maltose O-acetyltransferase activity
AWM72_RS07235	COG2151	metal-sulfur cluster biosynthetic enzyme
AWM72_RS07250	COG1316	TRANSCRIPTIONal
AWM72_RS07260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AWM72_RS07280	COG0095	Lipoate-protein ligase
AWM72_RS07285	COG4862	establishment of competence for transformation
AWM72_RS07290	COG1393	Belongs to the ArsC family
AWM72_RS07295	COG0180	Tryptophanyl-tRNA synthetase
AWM72_RS07310	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AWM72_RS07315	COG4116	CYTH
AWM72_RS07325	COG0564	pseudouridine synthase activity
AWM72_RS07330	COG2239	Acts as a magnesium transporter
AWM72_RS07335	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AWM72_RS07340	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AWM72_RS07345	COG0517	IMP dehydrogenase activity
AWM72_RS07350	COG0574	Belongs to the PEP-utilizing enzyme family
AWM72_RS07350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AWM72_RS07360	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AWM72_RS07365	COG0542	response to heat
AWM72_RS07370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM72_RS07375	COG4703	Protein of unknown function (DUF1797)
AWM72_RS07380	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AWM72_RS07385	COG0460	homoserine dehydrogenase
AWM72_RS07390	COG0083	homoserine kinase activity
AWM72_RS07395	COG0363	glucosamine-6-phosphate deaminase activity
AWM72_RS07410	COG1349	DNA-binding transcription factor activity
AWM72_RS07415	COG1105	Belongs to the carbohydrate kinase PfkB family
AWM72_RS07420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM72_RS07420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWM72_RS07420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWM72_RS07430	COG0343	queuine tRNA-ribosyltransferase activity
AWM72_RS07435	COG1862	Preprotein translocase
AWM72_RS07450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AWM72_RS07455	COG4109	DRTGG domain
AWM72_RS07460	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AWM72_RS07475	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AWM72_RS07490	COG0768	penicillin binding
AWM72_RS07495	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AWM72_RS07500	COG0705	Rhomboid family
AWM72_RS07500	COG0457	Tetratricopeptide repeat
AWM72_RS07505	COG1940	carbohydrate kinase activity
AWM72_RS07510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AWM72_RS07515	COG2094	Belongs to the DNA glycosylase MPG family
AWM72_RS07520	COG0525	valine-tRNA ligase activity
AWM72_RS07525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AWM72_RS07530	COG1278	Cold shock
AWM72_RS07535	COG2003	Belongs to the UPF0758 family
AWM72_RS07545	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AWM72_RS07550	COG1388	LysM domain
AWM72_RS07550	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM72_RS07555	COG0495	leucyl-tRNA aminoacylation
AWM72_RS07565	COG2244	polysaccharide biosynthetic process
AWM72_RS07570	COG1388	LysM domain
AWM72_RS07570	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM72_RS07575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM72_RS07580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWM72_RS07590	COG1733	regulation of RNA biosynthetic process
AWM72_RS07595	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AWM72_RS07600	COG0072	phenylalanine-tRNA ligase activity
AWM72_RS07600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM72_RS07605	COG0280	phosphate acetyltransferase
AWM72_RS07610	COG0802	atpase or kinase
AWM72_RS07625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AWM72_RS07630	COG1122	ATPase activity
AWM72_RS07645	COG1304	FMN binding
AWM72_RS07670	COG0668	transmembrane transport
AWM72_RS07680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AWM72_RS07685	COG1045	serine acetyltransferase
AWM72_RS07695	COG0019	diaminopimelate decarboxylase activity
AWM72_RS07710	COG1720	tRNA m6t6A37 methyltransferase activity
AWM72_RS07735	COG0765	amino acid transport
AWM72_RS07750	COG1193	negative regulation of DNA recombination
AWM72_RS07755	COG3118	belongs to the thioredoxin family
AWM72_RS07760	COG1803	Methylglyoxal synthase
AWM72_RS07765	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AWM72_RS07770	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AWM72_RS07775	COG0668	transmembrane transport
AWM72_RS07790	COG1609	Transcriptional regulator
AWM72_RS07810	COG1132	(ABC) transporter
AWM72_RS07815	COG1132	(ABC) transporter
AWM72_RS07820	COG0588	phosphoglycerate mutase activity
AWM72_RS07830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AWM72_RS07840	COG1394	ATPase activity, coupled to movement of substances
AWM72_RS07870	COG1269	ATP hydrolysis coupled proton transport
AWM72_RS07910	COG4537	Required for transformation and DNA binding
AWM72_RS07915	COG1459	type II secretion system
AWM72_RS07920	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AWM72_RS07925	COG0006	proline dipeptidase activity
AWM72_RS07930	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AWM72_RS07940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWM72_RS07945	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AWM72_RS07955	COG1722	exodeoxyribonuclease VII activity
AWM72_RS07965	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AWM72_RS07970	COG0497	DNA recombination
AWM72_RS07975	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AWM72_RS07980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AWM72_RS07995	COG1268	BioY protein
AWM72_RS08005	COG2384	SAM-dependent methyltransferase
AWM72_RS08010	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AWM72_RS08015	COG2195	Cleaves the N-terminal amino acid of tripeptides
AWM72_RS08020	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AWM72_RS08025	COG1074	ATP-dependent DNA helicase activity
AWM72_RS08040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AWM72_RS08045	COG0564	pseudouridine synthase activity
AWM72_RS08050	COG3763	UPF0154 protein
AWM72_RS08065	COG0052	Belongs to the universal ribosomal protein uS2 family
AWM72_RS08070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AWM72_RS08075	COG0528	UMP kinase activity
AWM72_RS08085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AWM72_RS08090	COG4589	Belongs to the CDS family
AWM72_RS08095	COG0750	zinc metalloprotease
AWM72_RS08100	COG2176	DNA-directed DNA polymerase activity
AWM72_RS08120	COG0779	Required for maturation of 30S ribosomal subunits
AWM72_RS08125	COG0195	Participates in both transcription termination and antitermination
AWM72_RS08130	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AWM72_RS08145	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AWM72_RS08150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM72_RS08155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AWM72_RS08160	COG0196	riboflavin kinase activity
AWM72_RS08165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AWM72_RS08170	COG1966	Carbon starvation protein
AWM72_RS08175	COG3279	Response regulator of the LytR AlgR family
AWM72_RS08180	COG3275	phosphorelay sensor kinase activity
AWM72_RS08195	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AWM72_RS08200	COG0443	Heat shock 70 kDa protein
AWM72_RS08205	COG0484	heat shock protein binding
AWM72_RS08210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWM72_RS08230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWM72_RS08255	COG0569	domain protein
AWM72_RS08265	COG0167	dihydroorotate dehydrogenase activity
AWM72_RS08270	COG3001	Fructosamine kinase
AWM72_RS08345	COG4120	Belongs to the binding-protein-dependent transport system permease family
AWM72_RS08350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AWM72_RS08360	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AWM72_RS08365	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AWM72_RS08365	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AWM72_RS08370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AWM72_RS08375	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AWM72_RS08380	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AWM72_RS08385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AWM72_RS08390	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AWM72_RS08395	COG1605	Chorismate mutase
AWM72_RS08395	COG0077	Prephenate dehydratase
AWM72_RS08420	COG0540	Belongs to the ATCase OTCase family
AWM72_RS08425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AWM72_RS08430	COG0505	Belongs to the CarA family
AWM72_RS08435	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AWM72_RS08440	COG0543	2 iron, 2 sulfur cluster binding
AWM72_RS08445	COG0167	dihydroorotate dehydrogenase activity
AWM72_RS08465	COG3588	fructose-bisphosphate aldolase
AWM72_RS08470	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AWM72_RS08475	COG0569	domain protein
AWM72_RS08480	COG1227	inorganic diphosphatase activity
AWM72_RS08490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWM72_RS08495	COG0187	DNA topoisomerase II activity
AWM72_RS08500	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AWM72_RS08505	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AWM72_RS08515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AWM72_RS08520	COG0758	DNA mediated transformation
AWM72_RS08525	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AWM72_RS08530	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AWM72_RS08535	COG0681	Belongs to the peptidase S26 family
AWM72_RS08540	COG3409	Peptidoglycan-binding domain 1 protein
AWM72_RS08540	COG0793	Belongs to the peptidase S41A family
AWM72_RS08545	COG4479	Belongs to the UPF0346 family
AWM72_RS08555	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AWM72_RS08560	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AWM72_RS08565	COG0488	(ABC) transporter
AWM72_RS08570	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AWM72_RS08575	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AWM72_RS08580	COG1780	Probably involved in ribonucleotide reductase function
AWM72_RS08585	COG0640	Transcriptional regulator
AWM72_RS08605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM72_RS08610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AWM72_RS08615	COG2131	deaminase
AWM72_RS08625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AWM72_RS08635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AWM72_RS08640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AWM72_RS08645	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AWM72_RS08650	COG1122	ATPase activity
AWM72_RS08665	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AWM72_RS08675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWM72_RS08680	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AWM72_RS08680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AWM72_RS08685	COG1234	tRNA 3'-trailer cleavage
AWM72_RS08695	COG0751	glycine-tRNA ligase activity
AWM72_RS08700	COG0752	glycyl-tRNA synthetase alpha subunit
AWM72_RS08705	COG1381	Involved in DNA repair and RecF pathway recombination
AWM72_RS08710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AWM72_RS08720	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AWM72_RS08725	COG1702	phosphate starvation-inducible protein PhoH
AWM72_RS08730	COG1610	YqeY-like protein
AWM72_RS08740	COG1472	Belongs to the glycosyl hydrolase 3 family
AWM72_RS08750	COG0735	belongs to the Fur family
AWM72_RS08755	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AWM72_RS08765	COG0616	signal peptide processing
AWM72_RS08770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AWM72_RS08775	COG0124	histidyl-tRNA synthetase
AWM72_RS08780	COG4991	sh3 domain protein
AWM72_RS08780	COG0860	N-Acetylmuramoyl-L-alanine amidase
AWM72_RS08780	COG3103	Sh3 type 3 domain protein
AWM72_RS08790	COG1187	pseudouridine synthase activity
AWM72_RS08795	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AWM72_RS08805	COG1335	isochorismatase
AWM72_RS08820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM72_RS08830	COG1490	D-aminoacyl-tRNA deacylase activity
AWM72_RS08835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AWM72_RS08840	COG2264	protein methyltransferase activity
AWM72_RS08850	COG3599	regulation of cell shape
AWM72_RS08860	COG0116	Belongs to the methyltransferase superfamily
AWM72_RS08885	COG0439	Biotin carboxylase
AWM72_RS08890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AWM72_RS08900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AWM72_RS08915	COG2070	2-Nitropropane dioxygenase
AWM72_RS08920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AWM72_RS08935	COG0588	phosphoglycerate mutase activity
AWM72_RS08940	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AWM72_RS08945	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AWM72_RS08950	COG0557	exoribonuclease II activity
AWM72_RS08965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AWM72_RS08970	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AWM72_RS08980	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AWM72_RS09000	COG0126	phosphoglycerate kinase activity
AWM72_RS09005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AWM72_RS09035	COG4753	response regulator
AWM72_RS09035	COG2207	Transcriptional regulator
AWM72_RS09040	COG0740	serine-type endopeptidase activity
AWM72_RS09070	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM72_RS09070	COG3942	CHAP domain
AWM72_RS09135	COG1802	Transcriptional regulator
AWM72_RS09135	COG4626	Terminase
AWM72_RS09140	COG1476	TRANSCRIPTIONal