locus-tag	class	description
I6G68_RS00005	COG0058	SHG alpha-glucan phosphorylase activity
I6G68_RS00010	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G68_RS00030	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G68_RS00035	COG3711	transcriptional antiterminator
I6G68_RS00040	COG2213	PTS system mannitol-specific
I6G68_RS00055	COG0765	amino acid transport
I6G68_RS00060	COG0165	Argininosuccinate lyase
I6G68_RS00065	COG0765	amino acid transport
I6G68_RS00070	COG1012	belongs to the aldehyde dehydrogenase family
I6G68_RS00075	COG1288	antiporter activity
I6G68_RS00080	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G68_RS00090	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G68_RS00095	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6G68_RS00100	COG0459	protein refolding
I6G68_RS00115	COG0488	(ABC) transporter
I6G68_RS00125	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6G68_RS00130	COG0456	acetyltransferase
I6G68_RS00140	COG1214	PFAM Peptidase M22, glycoprotease
I6G68_RS00145	COG4224	UPF0291 protein
I6G68_RS00155	COG1598	PFAM Uncharacterised protein family UPF0150
I6G68_RS00170	COG1518	maintenance of DNA repeat elements
I6G68_RS00185	COG1857	crispr-associated protein
I6G68_RS00205	COG0708	Exodeoxyribonuclease III
I6G68_RS00225	COG0435	Glutathione S-transferase
I6G68_RS00260	COG1051	belongs to the nudix hydrolase family
I6G68_RS00270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6G68_RS00270	COG0438	transferase activity, transferring glycosyl groups
I6G68_RS00285	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6G68_RS00290	COG1811	Na channel or pump
I6G68_RS00295	COG1114	Component of the transport system for branched-chain amino acids
I6G68_RS00305	COG1301	dicarboxylic acid transport
I6G68_RS00320	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G68_RS00325	COG1054	Belongs to the UPF0176 family
I6G68_RS00360	COG1304	FMN binding
I6G68_RS00370	COG1136	(ABC) transporter
I6G68_RS00380	COG0745	RESPONSE REGULATOR receiver
I6G68_RS00390	COG0134	indole-3-glycerol-phosphate synthase activity
I6G68_RS00400	COG0133	tryptophan synthase activity
I6G68_RS00405	COG0159	tryptophan synthase activity
I6G68_RS00410	COG0616	signal peptide processing
I6G68_RS00435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G68_RS00440	COG0519	Catalyzes the synthesis of GMP from XMP
I6G68_RS00475	COG1395	domain, Protein
I6G68_RS00485	COG1136	(ABC) transporter
I6G68_RS00490	COG5002	protein histidine kinase activity
I6G68_RS00495	COG0745	RESPONSE REGULATOR receiver
I6G68_RS00535	COG1131	(ABC) transporter
I6G68_RS00550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G68_RS00565	COG1131	(ABC) transporter
I6G68_RS00570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G68_RS00635	COG1122	ATPase activity
I6G68_RS00660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G68_RS00665	COG1073	alpha beta
I6G68_RS00670	COG0656	L-ascorbic acid biosynthetic process
I6G68_RS00680	COG1609	Transcriptional regulator
I6G68_RS00685	COG0737	Belongs to the 5'-nucleotidase family
I6G68_RS00690	COG3639	organic phosphonate transmembrane transporter activity
I6G68_RS00695	COG3639	organic phosphonate transmembrane transporter activity
I6G68_RS00700	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6G68_RS00720	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6G68_RS00725	COG0154	amidase activity
I6G68_RS00740	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6G68_RS00745	COG0210	DNA helicase
I6G68_RS00755	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6G68_RS00760	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6G68_RS00765	COG0517	IMP dehydrogenase activity
I6G68_RS00770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G68_RS00770	COG0574	Belongs to the PEP-utilizing enzyme family
I6G68_RS00780	COG0411	ABC transporter
I6G68_RS00815	COG0577	efflux transmembrane transporter activity
I6G68_RS00815	COG1136	(ABC) transporter
I6G68_RS00820	COG0561	phosphatase activity
I6G68_RS00825	COG4956	integral membrane protein (PIN domain superfamily)
I6G68_RS00830	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6G68_RS00835	COG0756	dUTP diphosphatase activity
I6G68_RS00855	COG1454	alcohol dehydrogenase
I6G68_RS00855	COG1012	belongs to the aldehyde dehydrogenase family
I6G68_RS00860	COG0352	thiamine-phosphate diphosphorylase activity
I6G68_RS00860	COG0351	phosphomethylpyrimidine kinase
I6G68_RS00865	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6G68_RS00875	COG0157	Belongs to the NadC ModD family
I6G68_RS00905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G68_RS00910	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6G68_RS00930	COG0626	cystathionine gamma-synthase activity
I6G68_RS00980	COG1473	amidohydrolase
I6G68_RS01010	COG1335	isochorismatase
I6G68_RS01020	COG1228	amidohydrolase
I6G68_RS01030	COG0133	tryptophan synthase activity
I6G68_RS01040	COG1620	l-lactate permease
I6G68_RS01050	COG1454	alcohol dehydrogenase
I6G68_RS01070	COG0305	Participates in initiation and elongation during chromosome replication
I6G68_RS01075	COG0359	binds to the 23S rRNA
I6G68_RS01080	COG0390	transport system, permease component
I6G68_RS01085	COG0390	transport system, permease component
I6G68_RS01090	COG4619	ABC transporter
I6G68_RS01110	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6G68_RS01115	COG0629	single-stranded DNA binding
I6G68_RS01120	COG0360	Binds together with S18 to 16S ribosomal RNA
I6G68_RS01125	COG1473	amidohydrolase
I6G68_RS01130	COG1288	antiporter activity
I6G68_RS01150	COG1668	transmembrane transport
I6G68_RS01155	COG4152	abc transporter atp-binding protein
I6G68_RS01160	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G68_RS01165	COG0187	DNA topoisomerase II activity
I6G68_RS01170	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6G68_RS01175	COG2501	S4 domain
I6G68_RS01180	COG0277	FAD linked oxidase domain protein
I6G68_RS01185	COG0592	DNA-directed DNA polymerase activity
I6G68_RS01200	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G68_RS01205	COG0022	dehydrogenase e1 component
I6G68_RS01210	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G68_RS01215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G68_RS01220	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6G68_RS01230	COG0706	membrane insertase activity
I6G68_RS01235	COG1847	R3H domain protein
I6G68_RS01240	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G68_RS01245	COG1960	acyl-CoA dehydrogenase activity
I6G68_RS01250	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6G68_RS01265	COG3715	PTS system
I6G68_RS01270	COG3716	PTS system mannose fructose sorbose family IID component
I6G68_RS01285	COG0393	Putative heavy-metal-binding
I6G68_RS01290	COG0628	permease
I6G68_RS01295	COG2217	Heavy metal translocating P-type atpase
I6G68_RS01300	COG4536	flavin adenine dinucleotide binding
I6G68_RS01305	COG0310	cobalt ion transport
I6G68_RS01320	COG1122	ATPase activity
I6G68_RS01325	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6G68_RS01335	COG0445	tRNA wobble uridine modification
I6G68_RS01345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G68_RS01380	COG1346	cytolysis
I6G68_RS01390	COG3279	Response regulator of the LytR AlgR family
I6G68_RS01395	COG3275	phosphorelay sensor kinase activity
I6G68_RS01400	COG0357	Ribosomal RNA small subunit methyltransferase G
I6G68_RS01405	COG1388	LysM domain
I6G68_RS01405	COG4932	domain protein
I6G68_RS01410	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G68_RS01430	COG2348	transferase activity, transferring amino-acyl groups
I6G68_RS01435	COG2244	polysaccharide biosynthetic process
I6G68_RS01445	COG1192	Involved in chromosome partitioning
I6G68_RS01450	COG1475	DNA binding
I6G68_RS01455	COG4481	Protein conserved in bacteria
I6G68_RS01460	COG0012	GTP binding
I6G68_RS01475	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6G68_RS01475	COG1388	LysM domain
I6G68_RS01485	COG0438	transferase activity, transferring glycosyl groups
I6G68_RS01500	COG5002	protein histidine kinase activity
I6G68_RS01515	COG3279	Response regulator of the LytR AlgR family
I6G68_RS01520	COG2391	methyltransferase activity
I6G68_RS01525	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G68_RS01530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G68_RS01545	COG1116	anion transmembrane transporter activity
I6G68_RS01550	COG0402	S-adenosylhomocysteine deaminase activity
I6G68_RS01555	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6G68_RS01560	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6G68_RS01570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G68_RS01585	COG2217	Heavy metal translocating P-type atpase
I6G68_RS01610	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6G68_RS01615	COG0789	Transcriptional regulator
I6G68_RS01620	COG0583	DNA-binding transcription factor activity
I6G68_RS01635	COG0471	metal ion transport
I6G68_RS01640	COG1053	succinate dehydrogenase
I6G68_RS01645	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G68_RS01650	COG3775	system Galactitol-specific IIC component
I6G68_RS01670	COG1349	DNA-binding transcription factor activity
I6G68_RS01675	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G68_RS01690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G68_RS01695	COG0778	Nitroreductase
I6G68_RS01700	COG0778	Nitroreductase
I6G68_RS01710	COG3118	belongs to the thioredoxin family
I6G68_RS01715	COG0483	inositol monophosphate 1-phosphatase activity
I6G68_RS01720	COG0583	DNA-binding transcription factor activity
I6G68_RS01725	COG1024	Enoyl-CoA hydratase
I6G68_RS01740	COG4115	mRNA cleavage
I6G68_RS01760	COG0456	acetyltransferase
I6G68_RS01775	COG1464	Belongs to the NlpA lipoprotein family
I6G68_RS01780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G68_RS01785	COG2011	ABC-type metal ion transport system permease component
I6G68_RS01895	COG3976	FMN-binding domain protein
I6G68_RS01895	COG1053	succinate dehydrogenase
I6G68_RS01900	COG1053	succinate dehydrogenase
I6G68_RS01900	COG3976	FMN-binding domain protein
I6G68_RS01900	COG0431	NADPH-dependent FMN reductase
I6G68_RS01905	COG1028	Short-chain dehydrogenase reductase Sdr
I6G68_RS01915	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6G68_RS01920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G68_RS01920	COG1263	PTS System
I6G68_RS01925	COG1737	Transcriptional regulator
I6G68_RS01930	COG3290	protein histidine kinase activity
I6G68_RS01935	COG4565	transcriptional regulatory protein
I6G68_RS01945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G68_RS01950	COG1053	succinate dehydrogenase
I6G68_RS01950	COG3976	FMN-binding domain protein
I6G68_RS01950	COG0431	NADPH-dependent FMN reductase
I6G68_RS01955	COG0583	DNA-binding transcription factor activity
I6G68_RS01960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6G68_RS01965	COG0738	Major facilitator superfamily
I6G68_RS01970	COG0710	3-dehydroquinate dehydratase activity
I6G68_RS01975	COG2851	Citrate transporter
I6G68_RS01980	COG0673	inositol 2-dehydrogenase activity
I6G68_RS01985	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G68_RS01990	COG3715	PTS system
I6G68_RS01995	COG3716	PTS system mannose fructose sorbose family IID component
I6G68_RS02005	COG1349	DNA-binding transcription factor activity
I6G68_RS02010	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G68_RS02015	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6G68_RS02020	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G68_RS02020	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G68_RS02025	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G68_RS02030	COG3715	PTS system
I6G68_RS02035	COG3716	PTS system mannose fructose sorbose family IID component
I6G68_RS02040	COG2390	Transcriptional regulator
I6G68_RS02050	COG2022	thiamine diphosphate biosynthetic process
I6G68_RS02060	COG1028	Short-chain dehydrogenase reductase Sdr
I6G68_RS02065	COG2390	Transcriptional regulator
I6G68_RS02070	COG4989	oxidoreductase activity
I6G68_RS02085	COG3414	Phosphotransferase system galactitol-specific IIB component
I6G68_RS02090	COG3775	system Galactitol-specific IIC component
I6G68_RS02095	COG1063	alcohol dehydrogenase
I6G68_RS02105	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G68_RS02115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G68_RS02130	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G68_RS02135	COG3730	PTS system glucitol sorbitol-specific
I6G68_RS02140	COG3732	PTS system glucitol sorbitol-specific
I6G68_RS02150	COG0693	protein deglycase activity
I6G68_RS02155	COG2070	2-Nitropropane dioxygenase
I6G68_RS02165	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6G68_RS02170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G68_RS02185	COG1942	4-Oxalocrotonate Tautomerase
I6G68_RS02230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6G68_RS02235	COG0420	3'-5' exonuclease activity
I6G68_RS02240	COG0419	ATPase involved in DNA repair
I6G68_RS02255	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6G68_RS02260	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6G68_RS02265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6G68_RS02275	COG0492	ferredoxin-NADP+ reductase activity
I6G68_RS02295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G68_RS02305	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6G68_RS02310	COG1481	regulation of sporulation
I6G68_RS02325	COG0745	RESPONSE REGULATOR receiver
I6G68_RS02330	COG3850	Histidine kinase
I6G68_RS02330	COG5002	protein histidine kinase activity
I6G68_RS02340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G68_RS02350	COG1028	Short-chain dehydrogenase reductase Sdr
I6G68_RS02365	COG3022	response to hydroperoxide
I6G68_RS02370	COG2190	(PTS) system
I6G68_RS02370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G68_RS02370	COG1263	PTS System
I6G68_RS02375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G68_RS02380	COG3189	MarR family transcriptional regulator
I6G68_RS02395	COG0366	Alpha amylase catalytic
I6G68_RS02400	COG0561	phosphatase activity
I6G68_RS02410	COG4684	Psort location CytoplasmicMembrane, score
I6G68_RS02415	COG1187	pseudouridine synthase activity
I6G68_RS02430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G68_RS02435	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6G68_RS02445	COG0215	cysteine-tRNA ligase activity
I6G68_RS02450	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6G68_RS02455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G68_RS02460	COG3688	RNA-binding protein containing a PIN domain
I6G68_RS02475	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G68_RS02480	COG0250	Participates in transcription elongation, termination and antitermination
I6G68_RS02490	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6G68_RS02495	COG0081	regulation of translation
I6G68_RS02500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6G68_RS02510	COG1609	Transcriptional regulator
I6G68_RS02515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G68_RS02525	COG2813	Specifically methylates the guanine in position
I6G68_RS02530	COG4175	Glycine betaine
I6G68_RS02530	COG3448	diguanylate cyclase activity
I6G68_RS02555	COG2848	UPF0210 protein
I6G68_RS02560	COG0584	glycerophosphoryl diester phosphodiesterase
I6G68_RS02565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G68_RS02575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6G68_RS02585	COG2096	Adenosyltransferase
I6G68_RS02635	COG1131	(ABC) transporter
I6G68_RS02645	COG1230	cation diffusion facilitator family transporter
I6G68_RS02650	COG4463	regulation of RNA biosynthetic process
I6G68_RS02655	COG0542	response to heat
I6G68_RS02665	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6G68_RS02670	COG0590	tRNA wobble adenosine to inosine editing
I6G68_RS02680	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6G68_RS02690	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6G68_RS02700	COG0470	DNA polymerase III
I6G68_RS02710	COG4467	Involved in initiation control of chromosome replication
I6G68_RS02715	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6G68_RS02725	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6G68_RS02735	COG1970	mechanosensitive ion channel activity
I6G68_RS02740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G68_RS02750	COG0436	Aminotransferase
I6G68_RS02755	COG1078	dGTPase activity
I6G68_RS02760	COG0095	Lipoate-protein ligase
I6G68_RS02770	COG3343	RNA polymerase activity
I6G68_RS02775	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G68_RS02780	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6G68_RS02785	COG0254	rRNA binding
I6G68_RS02790	COG3764	Sortase (surface protein transpeptidase)
I6G68_RS02805	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G68_RS02810	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G68_RS02820	COG0736	holo-[acyl-carrier-protein] synthase activity
I6G68_RS02825	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I6G68_RS02840	COG0789	Transcriptional regulator
I6G68_RS02850	COG1131	(ABC) transporter
I6G68_RS02860	COG1253	flavin adenine dinucleotide binding
I6G68_RS02885	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
I6G68_RS02890	COG0463	Glycosyl transferase, family 2
I6G68_RS02920	COG0322	excinuclease ABC activity
I6G68_RS02940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G68_RS02945	COG0193	aminoacyl-tRNA hydrolase activity
I6G68_RS02950	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G68_RS02955	COG2244	polysaccharide biosynthetic process
I6G68_RS02960	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6G68_RS02970	COG1098	S1 RNA binding domain
I6G68_RS02975	COG0037	tRNA processing
I6G68_RS02980	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6G68_RS02985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G68_RS02990	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6G68_RS03000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G68_RS03005	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6G68_RS03015	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6G68_RS03020	COG0049	tRNA binding
I6G68_RS03025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6G68_RS03030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G68_RS03040	COG0051	transcription antitermination factor activity, RNA binding
I6G68_RS03045	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6G68_RS03055	COG0089	rRNA binding
I6G68_RS03060	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6G68_RS03065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6G68_RS03080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6G68_RS03085	COG0255	Belongs to the universal ribosomal protein uL29 family
I6G68_RS03090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6G68_RS03095	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6G68_RS03105	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6G68_RS03110	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6G68_RS03115	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6G68_RS03125	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6G68_RS03130	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6G68_RS03135	COG1841	ribosomal large subunit assembly
I6G68_RS03140	COG0200	Binds to the 23S rRNA
I6G68_RS03155	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6G68_RS03160	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G68_RS03170	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6G68_RS03175	COG0202	RNA polymerase activity
I6G68_RS03180	COG0203	ribosomal protein L17
I6G68_RS03190	COG1122	ATPase activity
I6G68_RS03195	COG1122	ATPase activity
I6G68_RS03205	COG0101	tRNA pseudouridine synthase activity
I6G68_RS03220	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6G68_RS03250	COG2814	Major facilitator Superfamily
I6G68_RS03255	COG1902	pentaerythritol trinitrate reductase activity
I6G68_RS03260	COG1597	lipid kinase activity
I6G68_RS03265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G68_RS03280	COG0517	IMP dehydrogenase activity
I6G68_RS03280	COG1125	glycine betaine transport
I6G68_RS03300	COG0564	pseudouridine synthase activity
I6G68_RS03310	COG0604	alcohol dehydrogenase
I6G68_RS03315	COG0402	S-adenosylhomocysteine deaminase activity
I6G68_RS03335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G68_RS03340	COG0668	transmembrane transport
I6G68_RS03380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G68_RS03405	COG2137	regulation of response to DNA damage stimulus
I6G68_RS03410	COG1194	a g-specific adenine glycosylase
I6G68_RS03425	COG1523	belongs to the glycosyl hydrolase 13 family
I6G68_RS03430	COG4129	membrane
I6G68_RS03435	COG0735	belongs to the Fur family
I6G68_RS03440	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G68_RS03535	COG2059	Chromate
I6G68_RS03565	COG1653	transport
I6G68_RS03570	COG1653	transport
I6G68_RS03580	COG0395	ABC-type sugar transport system, permease component
I6G68_RS03585	COG3842	ATPase activity
I6G68_RS03590	COG1653	transport
I6G68_RS03650	COG0517	IMP dehydrogenase activity
I6G68_RS03650	COG0516	GMP reductase activity
I6G68_RS03655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G68_RS03660	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G68_RS03665	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6G68_RS03670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G68_RS03675	COG3679	Belongs to the UPF0342 family
I6G68_RS03680	COG0420	3'-5' exonuclease activity
I6G68_RS03685	COG4717	serine-type aminopeptidase activity
I6G68_RS03690	COG3481	metal-dependent phosphohydrolase, HD sub domain
I6G68_RS03695	COG1442	glycosyl transferase family 8
I6G68_RS03710	COG0537	adenosine 5'-monophosphoramidase activity
I6G68_RS03715	COG1131	(ABC) transporter
I6G68_RS03730	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6G68_RS03740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G68_RS03750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G68_RS03755	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G68_RS03775	COG0495	leucyl-tRNA aminoacylation
I6G68_RS03785	COG1126	abc transporter atp-binding protein
I6G68_RS03790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G68_RS03795	COG0765	amino acid transport
I6G68_RS03810	COG2244	polysaccharide biosynthetic process
I6G68_RS03815	COG1640	4-alpha-glucanotransferase
I6G68_RS03825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G68_RS03835	COG1733	regulation of RNA biosynthetic process
I6G68_RS03840	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6G68_RS03845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G68_RS03845	COG0072	phenylalanine-tRNA ligase activity
I6G68_RS03850	COG1115	amino acid carrier protein
I6G68_RS03855	COG0280	phosphate acetyltransferase
I6G68_RS03875	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6G68_RS03880	COG4475	Protein of unknown function (DUF436)
I6G68_RS03885	COG0802	atpase or kinase
I6G68_RS03900	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6G68_RS03905	COG1122	ATPase activity
I6G68_RS03910	COG0406	alpha-ribazole phosphatase activity
I6G68_RS03930	COG1116	anion transmembrane transporter activity
I6G68_RS03930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G68_RS03950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G68_RS03960	COG3579	cysteine-type endopeptidase activity
I6G68_RS03965	COG0577	efflux transmembrane transporter activity
I6G68_RS03970	COG1136	(ABC) transporter
I6G68_RS03975	COG3949	Membrane
I6G68_RS03995	COG1132	(ABC) transporter
I6G68_RS04005	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6G68_RS04015	COG1191	sigma factor activity
I6G68_RS04055	COG2190	(PTS) system
I6G68_RS04055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G68_RS04055	COG1263	PTS System
I6G68_RS04080	COG0588	phosphoglycerate mutase activity
I6G68_RS04085	COG0588	phosphoglycerate mutase activity
I6G68_RS04090	COG0431	NADPH-dependent FMN reductase
I6G68_RS04100	COG0028	Belongs to the TPP enzyme family
I6G68_RS04110	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G68_RS04110	COG2918	glutathione biosynthetic process
I6G68_RS04115	COG3842	ATPase activity
I6G68_RS04120	COG1175	transmembrane transport
I6G68_RS04125	COG0395	ABC-type sugar transport system, permease component
I6G68_RS04150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G68_RS04160	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6G68_RS04180	COG0431	NADPH-dependent FMN reductase
I6G68_RS04185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G68_RS04195	COG1464	Belongs to the NlpA lipoprotein family
I6G68_RS04235	COG1073	alpha beta
I6G68_RS04245	COG0653	protein targeting
I6G68_RS04255	COG1442	glycosyl transferase family 8
I6G68_RS04255	COG1216	Glycosyl transferase, family 2
I6G68_RS04270	COG1045	serine acetyltransferase
I6G68_RS04275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G68_RS04280	COG1304	FMN binding
I6G68_RS04295	COG0083	homoserine kinase activity
I6G68_RS04300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G68_RS04300	COG0519	Catalyzes the synthesis of GMP from XMP
I6G68_RS04325	COG1363	Peptidase, m42
I6G68_RS04335	COG0596	Alpha beta hydrolase
I6G68_RS04340	COG1720	tRNA m6t6A37 methyltransferase activity
I6G68_RS04360	COG1136	(ABC) transporter
I6G68_RS04360	COG0577	efflux transmembrane transporter activity
I6G68_RS04375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G68_RS04375	COG1263	PTS System
I6G68_RS04395	COG3118	belongs to the thioredoxin family
I6G68_RS04405	COG1803	Methylglyoxal synthase
I6G68_RS04410	COG0786	glutamate:sodium symporter activity
I6G68_RS04420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6G68_RS04425	COG0622	Phosphoesterase
I6G68_RS04430	COG0668	transmembrane transport
I6G68_RS04440	COG4980	gas vesicle protein
I6G68_RS04445	COG1394	ATPase activity, coupled to movement of substances
I6G68_RS04475	COG1269	ATP hydrolysis coupled proton transport
I6G68_RS04490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G68_RS04495	COG1459	type II secretion system
I6G68_RS04500	COG4537	Required for transformation and DNA binding
I6G68_RS04525	COG0006	proline dipeptidase activity
I6G68_RS04530	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6G68_RS04540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G68_RS04545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6G68_RS04550	COG1570	exodeoxyribonuclease VII activity
I6G68_RS04565	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6G68_RS04570	COG0497	DNA recombination
I6G68_RS04575	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6G68_RS04580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G68_RS04605	COG1053	succinate dehydrogenase
I6G68_RS04605	COG3976	FMN-binding domain protein
I6G68_RS04610	COG1316	TRANSCRIPTIONal
I6G68_RS04615	COG3944	biosynthesis protein
I6G68_RS04620	COG0489	protein tyrosine kinase activity
I6G68_RS04625	COG4464	protein tyrosine phosphatase activity
I6G68_RS04635	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G68_RS04650	COG1086	Polysaccharide biosynthesis protein
I6G68_RS04675	COG1216	Glycosyl transferase, family 2
I6G68_RS04675	COG1442	glycosyl transferase family 8
I6G68_RS04680	COG1215	transferase activity, transferring glycosyl groups
I6G68_RS04685	COG2244	polysaccharide biosynthetic process
I6G68_RS04775	COG2326	polyphosphate kinase activity
I6G68_RS04780	COG3620	sequence-specific DNA binding
I6G68_RS04790	COG0308	aminopeptidase N
I6G68_RS04805	COG0561	phosphatase activity
I6G68_RS04815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G68_RS04830	COG1295	ribonuclease BN
I6G68_RS04835	COG0772	Belongs to the SEDS family
I6G68_RS04840	COG1393	Belongs to the ArsC family
I6G68_RS04855	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6G68_RS04860	COG3590	peptidase
I6G68_RS04865	COG4166	transmembrane transport
I6G68_RS04870	COG4166	transmembrane transport
I6G68_RS04875	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G68_RS04880	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I6G68_RS04885	COG0018	arginyl-trna synthetase
I6G68_RS04915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G68_RS04930	COG2084	Dehydrogenase
I6G68_RS04955	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6G68_RS04960	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6G68_RS04965	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6G68_RS04970	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G68_RS04975	COG0047	phosphoribosylformylglycinamidine synthase activity
I6G68_RS04980	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G68_RS04985	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6G68_RS04990	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6G68_RS04995	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G68_RS05000	COG0138	bifunctional purine biosynthesis protein purh
I6G68_RS05005	COG0151	Belongs to the GarS family
I6G68_RS05010	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G68_RS05025	COG2321	neutral zinc metallopeptidase
I6G68_RS05030	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G68_RS05040	COG2183	response to ionizing radiation
I6G68_RS05050	COG0039	L-malate dehydrogenase activity
I6G68_RS05080	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G68_RS05085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G68_RS05100	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G68_RS05105	COG1104	cysteine desulfurase activity
I6G68_RS05115	COG0482	sulfurtransferase activity
I6G68_RS05120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G68_RS05130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G68_RS05135	COG4472	Bacterial protein of unknown function (DUF965)
I6G68_RS05145	COG3906	Belongs to the UPF0473 family
I6G68_RS05150	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G68_RS05155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G68_RS05160	COG1114	Component of the transport system for branched-chain amino acids
I6G68_RS05175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G68_RS05180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G68_RS05185	COG2070	2-Nitropropane dioxygenase
I6G68_RS05190	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6G68_RS05200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G68_RS05210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G68_RS05215	COG0439	Biotin carboxylase
I6G68_RS05220	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6G68_RS05225	COG0825	malonyl-CoA metabolic process
I6G68_RS05235	COG0328	RNA-DNA hybrid ribonuclease activity
I6G68_RS05240	COG3976	FMN-binding domain protein
I6G68_RS05240	COG1053	succinate dehydrogenase
I6G68_RS05255	COG1053	succinate dehydrogenase
I6G68_RS05255	COG3976	FMN-binding domain protein
I6G68_RS05260	COG3949	Membrane
I6G68_RS05270	COG0483	inositol monophosphate 1-phosphatase activity
I6G68_RS05280	COG0116	Belongs to the methyltransferase superfamily
I6G68_RS05290	COG3599	regulation of cell shape
I6G68_RS05300	COG2264	protein methyltransferase activity
I6G68_RS05305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G68_RS05310	COG1490	D-aminoacyl-tRNA deacylase activity
I6G68_RS05320	COG0124	histidyl-tRNA synthetase
I6G68_RS05325	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6G68_RS05340	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6G68_RS05345	COG0735	belongs to the Fur family
I6G68_RS05355	COG1744	ABC transporter substrate-binding protein PnrA-like
I6G68_RS05360	COG3845	ABC transporter
I6G68_RS05365	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6G68_RS05370	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6G68_RS05385	COG1610	YqeY-like protein
I6G68_RS05390	COG1702	phosphate starvation-inducible protein PhoH
I6G68_RS05395	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6G68_RS05405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6G68_RS05410	COG1381	Involved in DNA repair and RecF pathway recombination
I6G68_RS05415	COG0752	glycyl-tRNA synthetase alpha subunit
I6G68_RS05420	COG0751	glycine-tRNA ligase activity
I6G68_RS05435	COG4221	oxidoreductase activity
I6G68_RS05440	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6G68_RS05440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6G68_RS05445	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G68_RS05455	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6G68_RS05465	COG2131	deaminase
I6G68_RS05470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6G68_RS05475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6G68_RS05480	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G68_RS05485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G68_RS05490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G68_RS05510	COG1597	lipid kinase activity
I6G68_RS05515	COG0392	lysyltransferase activity
I6G68_RS05515	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6G68_RS05535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G68_RS05545	COG2832	Protein of unknown function (DUF454)
I6G68_RS05550	COG3001	Fructosamine kinase
I6G68_RS05555	COG0561	phosphatase activity
I6G68_RS05575	COG2032	superoxide dismutase activity
I6G68_RS05595	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6G68_RS05645	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6G68_RS05650	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G68_RS05655	COG2610	gluconate transmembrane transporter activity
I6G68_RS05665	COG1737	Transcriptional regulator
I6G68_RS05670	COG1116	anion transmembrane transporter activity
I6G68_RS05675	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6G68_RS05685	COG1227	inorganic diphosphatase activity
I6G68_RS05690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G68_RS05695	COG0187	DNA topoisomerase II activity
I6G68_RS05700	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6G68_RS05705	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6G68_RS05715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G68_RS05720	COG0758	DNA mediated transformation
I6G68_RS05725	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6G68_RS05740	COG0793	Belongs to the peptidase S41A family
I6G68_RS05740	COG3409	Peptidoglycan-binding domain 1 protein
I6G68_RS05745	COG4479	Belongs to the UPF0346 family
I6G68_RS05755	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6G68_RS05765	COG0488	(ABC) transporter
I6G68_RS05770	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6G68_RS05780	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6G68_RS05790	COG0481	GTPase activity
I6G68_RS05795	COG0484	heat shock protein binding
I6G68_RS05810	COG1420	regulation of RNA biosynthetic process
I6G68_RS05815	COG0196	riboflavin kinase activity
I6G68_RS05825	COG0514	ATP-dependent DNA helicase (RecQ)
I6G68_RS05835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G68_RS05840	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6G68_RS05850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6G68_RS05865	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6G68_RS05870	COG0195	Participates in both transcription termination and antitermination
I6G68_RS05895	COG2176	DNA-directed DNA polymerase activity
I6G68_RS05900	COG0750	zinc metalloprotease
I6G68_RS05905	COG4589	Belongs to the CDS family
I6G68_RS05910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G68_RS05920	COG0528	UMP kinase activity
I6G68_RS05925	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6G68_RS05930	COG0052	Belongs to the universal ribosomal protein uS2 family
I6G68_RS05945	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G68_RS05950	COG0183	Belongs to the thiolase family
I6G68_RS05960	COG2610	gluconate transmembrane transporter activity
I6G68_RS05965	COG1028	Short-chain dehydrogenase reductase Sdr
I6G68_RS05970	COG0583	DNA-binding transcription factor activity
I6G68_RS05975	COG1024	Enoyl-CoA hydratase
I6G68_RS05980	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6G68_RS05985	COG1687	branched-chain amino acid
I6G68_RS05990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6G68_RS05995	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6G68_RS06015	COG0204	Acyl-transferase
I6G68_RS06020	COG3763	UPF0154 protein
I6G68_RS06025	COG0564	pseudouridine synthase activity
I6G68_RS06030	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6G68_RS06045	COG1074	ATP-dependent DNA helicase activity
I6G68_RS06050	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6G68_RS06055	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G68_RS06075	COG0297	glycogen (starch) synthase activity
I6G68_RS06080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6G68_RS06095	COG0346	lactoylglutathione lyase activity
I6G68_RS06105	COG1307	EDD domain protein, DegV family
I6G68_RS06125	COG1132	(ABC) transporter
I6G68_RS06140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6G68_RS06150	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6G68_RS06155	COG0167	dihydroorotate dehydrogenase activity
I6G68_RS06165	COG0540	Belongs to the ATCase OTCase family
I6G68_RS06175	COG0505	Belongs to the CarA family
I6G68_RS06180	COG1126	abc transporter atp-binding protein
I6G68_RS06185	COG0765	amino acid transport
I6G68_RS06195	COG1792	Involved in formation and maintenance of cell shape
I6G68_RS06205	COG0527	aspartate kinase activity
I6G68_RS06210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G68_RS06215	COG0358	DNA primase activity
I6G68_RS06220	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6G68_RS06230	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6G68_RS06235	COG3331	DNA recombination
I6G68_RS06245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6G68_RS06255	COG3682	Transcriptional regulator
I6G68_RS06260	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6G68_RS06265	COG0561	phosphatase activity
I6G68_RS06270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G68_RS06280	COG0488	(ABC) transporter
I6G68_RS06285	COG1126	abc transporter atp-binding protein
I6G68_RS06290	COG0765	amino acid transport
I6G68_RS06295	COG0765	amino acid transport
I6G68_RS06300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G68_RS06315	COG1132	(ABC) transporter
I6G68_RS06320	COG0628	permease
I6G68_RS06325	COG1072	(Pantothenic acid kinase))
I6G68_RS06335	COG4841	protein insertion into membrane
I6G68_RS06355	COG1272	protein, Hemolysin III
I6G68_RS06360	COG5503	Protein of unknown function (DUF1447)
I6G68_RS06365	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6G68_RS06375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G68_RS06390	COG0009	L-threonylcarbamoyladenylate synthase
I6G68_RS06395	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G68_RS06400	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6G68_RS06410	COG3442	glutamine amidotransferase
I6G68_RS06415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G68_RS06420	COG0628	permease
I6G68_RS06425	COG2706	6-phosphogluconolactonase activity
I6G68_RS06430	COG1968	undecaprenyl-diphosphatase activity
I6G68_RS06435	COG0686	Belongs to the AlaDH PNT family
I6G68_RS06440	COG1748	Saccharopine dehydrogenase
I6G68_RS06445	COG0019	diaminopimelate decarboxylase activity
I6G68_RS06450	COG0704	Plays a role in the regulation of phosphate uptake
I6G68_RS06455	COG2814	Major facilitator Superfamily
I6G68_RS06460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6G68_RS06485	COG2207	Transcriptional regulator
I6G68_RS06485	COG1917	Cupin 2, conserved barrel domain protein
I6G68_RS06490	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6G68_RS06495	COG0557	exoribonuclease II activity
I6G68_RS06510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G68_RS06525	COG0647	UMP catabolic process
I6G68_RS06530	COG4470	Protein conserved in bacteria
I6G68_RS06535	COG0148	phosphopyruvate hydratase activity
I6G68_RS06550	COG2390	Transcriptional regulator
I6G68_RS06555	COG0740	serine-type endopeptidase activity
I6G68_RS06575	COG1464	Belongs to the NlpA lipoprotein family
I6G68_RS06580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G68_RS06580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G68_RS06580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G68_RS06585	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G68_RS06590	COG1349	DNA-binding transcription factor activity
I6G68_RS06730	COG0166	Belongs to the GPI family
I6G68_RS06735	COG1098	S1 RNA binding domain
I6G68_RS06740	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G68_RS06745	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I6G68_RS06755	COG3935	DnaD domain protein
I6G68_RS06780	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6G68_RS06795	COG1160	GTP binding
I6G68_RS06800	COG0539	negative regulation of cytoplasmic translation
I6G68_RS06815	COG0514	ATP-dependent DNA helicase (RecQ)
I6G68_RS06830	COG4372	Transposase
I6G68_RS06840	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6G68_RS06845	COG1187	pseudouridine synthase activity
I6G68_RS06850	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6G68_RS06855	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6G68_RS06875	COG3344	reverse transcriptase
I6G68_RS06885	COG2996	Protein conserved in bacteria
I6G68_RS06895	COG0205	6-phosphofructokinase activity
I6G68_RS06900	COG0587	DNA-directed DNA polymerase activity
I6G68_RS06905	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6G68_RS06910	COG2255	four-way junction helicase activity
I6G68_RS06925	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6G68_RS06930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6G68_RS07070	COG0582	viral genome integration into host DNA
I6G68_RS07080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6G68_RS07085	COG1546	Belongs to the CinA family
I6G68_RS07085	COG1058	Belongs to the CinA family
I6G68_RS07090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G68_RS07095	COG1280	lysine exporter protein (LysE YggA)
I6G68_RS07095	COG1674	ftsk spoiiie
I6G68_RS07100	COG1254	Belongs to the acylphosphatase family
I6G68_RS07105	COG0706	membrane insertase activity
I6G68_RS07110	COG0745	RESPONSE REGULATOR receiver
I6G68_RS07115	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6G68_RS07130	COG1104	cysteine desulfurase activity
I6G68_RS07135	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I6G68_RS07140	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6G68_RS07145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G68_RS07155	COG0494	nUDIX hydrolase
I6G68_RS07165	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G68_RS07170	COG1278	Cold shock
I6G68_RS07175	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6G68_RS07180	COG3599	regulation of cell shape
I6G68_RS07185	COG2302	S4 RNA-binding domain
I6G68_RS07190	COG0762	integral membrane protein
I6G68_RS07195	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6G68_RS07205	COG0849	cell division
I6G68_RS07210	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6G68_RS07230	COG0768	penicillin binding
I6G68_RS07265	COG1323	Belongs to the UPF0348 family
I6G68_RS07270	COG2226	methyltransferase
I6G68_RS07275	COG0799	negative regulation of ribosome biogenesis
I6G68_RS07280	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6G68_RS07285	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6G68_RS07290	COG1534	Rna-binding protein
I6G68_RS07295	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6G68_RS07300	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6G68_RS07305	COG0083	homoserine kinase activity
I6G68_RS07310	COG0460	homoserine dehydrogenase
I6G68_RS07315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G68_RS07325	COG0438	transferase activity, transferring glycosyl groups
I6G68_RS07340	COG0542	response to heat
I6G68_RS07345	COG0517	IMP dehydrogenase activity
I6G68_RS07345	COG0516	GMP reductase activity
I6G68_RS07350	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6G68_RS07360	COG0765	amino acid transport
I6G68_RS07365	COG1394	ATPase activity, coupled to movement of substances
I6G68_RS07370	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
I6G68_RS07375	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
I6G68_RS07385	COG1527	subunit (C
I6G68_RS07395	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6G68_RS07400	COG1269	ATP hydrolysis coupled proton transport
I6G68_RS07415	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6G68_RS07420	COG2239	Acts as a magnesium transporter
I6G68_RS07425	COG0564	pseudouridine synthase activity
I6G68_RS07450	COG0180	Tryptophanyl-tRNA synthetase
I6G68_RS07455	COG1393	Belongs to the ArsC family
I6G68_RS07460	COG4862	establishment of competence for transformation
I6G68_RS07480	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G68_RS07485	COG0783	Belongs to the Dps family
I6G68_RS07490	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6G68_RS07500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6G68_RS07510	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6G68_RS07520	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G68_RS07525	COG1484	DNA-dependent DNA replication
I6G68_RS07530	COG3611	Membrane attachment protein
I6G68_RS07535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6G68_RS07545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6G68_RS07550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G68_RS07550	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G68_RS07560	COG1388	LysM domain
I6G68_RS07560	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6G68_RS07565	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6G68_RS07575	COG2003	Belongs to the UPF0758 family
I6G68_RS07580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6G68_RS07585	COG0525	valine-tRNA ligase activity
I6G68_RS07590	COG2094	Belongs to the DNA glycosylase MPG family
I6G68_RS07595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G68_RS07600	COG1940	carbohydrate kinase activity
I6G68_RS07605	COG0705	Rhomboid family
I6G68_RS07605	COG0457	Tetratricopeptide repeat
I6G68_RS07610	COG1028	Short-chain dehydrogenase reductase Sdr
I6G68_RS07625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G68_RS07630	COG0768	penicillin binding
I6G68_RS07640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G68_RS07650	COG0513	Belongs to the DEAD box helicase family
I6G68_RS07655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6G68_RS07660	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6G68_RS07665	COG4109	DRTGG domain
I6G68_RS07685	COG0343	queuine tRNA-ribosyltransferase activity
I6G68_RS07690	COG0542	response to heat
I6G68_RS07700	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G68_RS07705	COG0022	dehydrogenase e1 component
I6G68_RS07710	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G68_RS07715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G68_RS07725	COG2070	2-Nitropropane dioxygenase
I6G68_RS07730	COG0583	DNA-binding transcription factor activity
I6G68_RS07740	COG1024	Enoyl-CoA hydratase
I6G68_RS07745	COG3426	butyrate kinase activity
I6G68_RS07750	COG0280	phosphate acetyltransferase
I6G68_RS07755	COG1012	belongs to the aldehyde dehydrogenase family
I6G68_RS07760	COG4221	oxidoreductase activity
I6G68_RS07765	COG0583	DNA-binding transcription factor activity
I6G68_RS07785	COG0335	large ribosomal subunit rRNA binding
I6G68_RS07795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6G68_RS07800	COG1837	Belongs to the UPF0109 family
I6G68_RS07805	COG0228	four-way junction DNA binding
I6G68_RS07815	COG4864	UPF0365 protein
I6G68_RS07825	COG1132	(ABC) transporter
I6G68_RS07840	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G68_RS07850	COG0552	protein localization to endoplasmic reticulum
I6G68_RS07855	COG0561	phosphatase activity
I6G68_RS07860	COG1196	nuclear chromosome segregation
I6G68_RS07865	COG0571	ribonuclease III activity
I6G68_RS07870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G68_RS07875	COG0416	fatty acid biosynthetic process
I6G68_RS07880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6G68_RS07885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G68_RS07890	COG1461	Dihydroxyacetone kinase
I6G68_RS07895	COG1302	Protein conserved in bacteria
I6G68_RS07900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6G68_RS07910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G68_RS07915	COG1162	GTPase activity
I6G68_RS07920	COG2815	serine threonine protein kinase
I6G68_RS07920	COG0515	serine threonine protein kinase
I6G68_RS07930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G68_RS07930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G68_RS07935	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6G68_RS07940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G68_RS07945	COG1758	RNA polymerase activity
I6G68_RS07950	COG0194	GDP metabolic process
I6G68_RS07960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G68_RS07975	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G68_RS07980	COG3344	reverse transcriptase
I6G68_RS07985	COG1185	polyribonucleotide nucleotidyltransferase activity
I6G68_RS07990	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6G68_RS07995	COG0671	phosphoesterase, PA-phosphatase related
I6G68_RS08005	COG0268	Binds directly to 16S ribosomal RNA
I6G68_RS08015	COG2333	competence protein COMEC
I6G68_RS08015	COG0658	competence protein
I6G68_RS08020	COG1596	polysaccharide export
I6G68_RS08020	COG1555	photosystem II stabilization
I6G68_RS08025	COG0742	ribosomal rna small subunit methyltransferase
I6G68_RS08035	COG3344	reverse transcriptase
I6G68_RS08045	COG4471	UPF0298 protein
I6G68_RS08050	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6G68_RS08055	COG0772	Belongs to the SEDS family
I6G68_RS08060	COG1217	gtp-binding protein TYPA
I6G68_RS08065	COG0483	inositol monophosphate 1-phosphatase activity
I6G68_RS08070	COG4476	Belongs to the UPF0223 family
I6G68_RS08075	COG1187	pseudouridine synthase activity
I6G68_RS08080	COG0765	amino acid transport
I6G68_RS08085	COG0765	amino acid transport
I6G68_RS08090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G68_RS08125	COG0242	peptide deformylase activity
I6G68_RS08135	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6G68_RS08140	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6G68_RS08145	COG2855	membrane
I6G68_RS08155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G68_RS08195	COG3425	synthase
I6G68_RS08200	COG4608	Belongs to the ABC transporter superfamily
I6G68_RS08205	COG0444	Belongs to the ABC transporter superfamily
I6G68_RS08210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G68_RS08215	COG0601	transmembrane transport
I6G68_RS08225	COG4166	transmembrane transport
I6G68_RS08230	COG4166	transmembrane transport
I6G68_RS08235	COG4166	transmembrane transport
I6G68_RS08240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G68_RS08245	COG0006	proline dipeptidase activity
I6G68_RS08255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6G68_RS08260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G68_RS08300	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6G68_RS08305	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6G68_RS08320	COG0489	protein tyrosine kinase activity
I6G68_RS08335	COG1051	belongs to the nudix hydrolase family
I6G68_RS08340	COG1307	EDD domain protein, DegV family
I6G68_RS08350	COG0516	GMP reductase activity
I6G68_RS08355	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6G68_RS08360	COG1316	TRANSCRIPTIONal
I6G68_RS08365	COG0024	Methionine aminopeptidase
I6G68_RS08375	COG0716	FMN binding
I6G68_RS08395	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6G68_RS08395	COG0463	Glycosyl transferase, family 2
I6G68_RS08405	COG1216	Glycosyl transferase, family 2
I6G68_RS08410	COG1216	Glycosyl transferase, family 2
I6G68_RS08415	COG1216	Glycosyl transferase, family 2
I6G68_RS08425	COG2089	acid synthase
I6G68_RS08430	COG1083	cytidylyl-transferase
I6G68_RS08460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G68_RS08465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G68_RS08470	COG1121	(ABC) transporter
I6G68_RS08475	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6G68_RS08475	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6G68_RS08480	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6G68_RS08485	COG4466	Protein conserved in bacteria
I6G68_RS08500	COG4555	ABC transporter
I6G68_RS08505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6G68_RS08515	COG0084	hydrolase, TatD family'
I6G68_RS08520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G68_RS08520	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G68_RS08530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6G68_RS08545	COG2738	Putative neutral zinc metallopeptidase
I6G68_RS08565	COG0436	Aminotransferase
I6G68_RS08570	COG1522	sequence-specific DNA binding
I6G68_RS08580	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6G68_RS08585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G68_RS08590	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6G68_RS08610	COG5002	protein histidine kinase activity
I6G68_RS08615	COG0745	RESPONSE REGULATOR receiver
I6G68_RS08620	COG3942	CHAP domain
I6G68_RS08625	COG0038	chloride channel
I6G68_RS08640	COG1268	BioY protein
I6G68_RS08650	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6G68_RS08650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G68_RS08655	COG0561	phosphatase activity
I6G68_RS08675	COG1957	nucleoside hydrolase
I6G68_RS08695	COG0181	hydroxymethylbilane synthase activity
I6G68_RS08710	COG1492	cobalamin metabolic process
I6G68_RS08760	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I6G68_RS08770	COG1797	cobyrinic acid a,c-diamide synthase activity
I6G68_RS08780	COG4166	transmembrane transport
I6G68_RS08790	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6G68_RS08795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G68_RS08800	COG0406	alpha-ribazole phosphatase activity
I6G68_RS08805	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I6G68_RS08810	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
I6G68_RS08825	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6G68_RS08830	COG0549	Belongs to the carbamate kinase family
I6G68_RS08845	COG0542	response to heat
I6G68_RS08850	COG1115	amino acid carrier protein
I6G68_RS08855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6G68_RS08860	COG2207	Transcriptional regulator
I6G68_RS08870	COG1691	(AIR) carboxylase
I6G68_RS08875	COG1606	tRNA processing
I6G68_RS08880	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
I6G68_RS08885	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
I6G68_RS08900	COG0435	Glutathione S-transferase
I6G68_RS08915	COG2205	protein histidine kinase activity
I6G68_RS08925	COG1131	(ABC) transporter
I6G68_RS08930	COG0095	Lipoate-protein ligase
I6G68_RS08940	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6G68_RS08940	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6G68_RS08945	COG3250	beta-galactosidase activity
I6G68_RS08955	COG0569	domain protein
I6G68_RS08960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G68_RS08970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G68_RS08975	COG0581	inorganic phosphate transmembrane transporter activity
I6G68_RS08980	COG0573	inorganic phosphate transmembrane transporter activity
I6G68_RS08990	COG5002	protein histidine kinase activity
I6G68_RS08995	COG0745	RESPONSE REGULATOR receiver
I6G68_RS09005	COG0653	protein targeting
I6G68_RS09015	COG1040	competence protein
I6G68_RS09020	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6G68_RS09025	COG1739	Uncharacterized protein family UPF0029
I6G68_RS09030	COG0800	Aldolase
I6G68_RS09035	COG1428	Deoxynucleoside kinase