locus-tag	class	description
AWM74_RS00030	COG0488	(ABC) transporter
AWM74_RS00040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AWM74_RS00045	COG0717	Belongs to the dCTP deaminase family
AWM74_RS00055	COG1063	alcohol dehydrogenase
AWM74_RS00060	COG1028	Short-chain dehydrogenase reductase Sdr
AWM74_RS00075	COG0484	heat shock protein binding
AWM74_RS00080	COG0443	Heat shock 70 kDa protein
AWM74_RS00085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AWM74_RS00090	COG1420	regulation of RNA biosynthetic process
AWM74_RS00095	COG1473	amidohydrolase
AWM74_RS00100	COG0196	riboflavin kinase activity
AWM74_RS00105	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AWM74_RS00110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AWM74_RS00115	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AWM74_RS00125	COG0009	L-threonylcarbamoyladenylate synthase
AWM74_RS00130	COG2890	protein-(glutamine-N5) methyltransferase activity
AWM74_RS00135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AWM74_RS00140	COG1435	thymidine kinase activity
AWM74_RS00145	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AWM74_RS00150	COG3442	glutamine amidotransferase
AWM74_RS00155	COG2135	peptidase activity
AWM74_RS00165	COG1132	(ABC) transporter
AWM74_RS00170	COG0628	permease
AWM74_RS00175	COG2706	6-phosphogluconolactonase activity
AWM74_RS00180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AWM74_RS00185	COG1079	Belongs to the binding-protein-dependent transport system permease family
AWM74_RS00190	COG4603	Belongs to the binding-protein-dependent transport system permease family
AWM74_RS00195	COG3845	ABC transporter
AWM74_RS00200	COG1744	ABC transporter substrate-binding protein PnrA-like
AWM74_RS00205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM74_RS00205	COG1263	PTS System
AWM74_RS00205	COG2190	(PTS) system
AWM74_RS00210	COG1968	undecaprenyl-diphosphatase activity
AWM74_RS00215	COG0527	aspartate kinase activity
AWM74_RS00220	COG0297	glycogen (starch) synthase activity
AWM74_RS00225	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AWM74_RS00230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AWM74_RS00245	COG0346	lactoylglutathione lyase activity
AWM74_RS00265	COG0517	IMP dehydrogenase activity
AWM74_RS00270	COG0683	leucine binding
AWM74_RS00275	COG2183	response to ionizing radiation
AWM74_RS00295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWM74_RS00315	COG0018	arginyl-trna synthetase
AWM74_RS00325	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AWM74_RS00335	COG0577	efflux transmembrane transporter activity
AWM74_RS00335	COG1136	(ABC) transporter
AWM74_RS00345	COG0509	glycine decarboxylation via glycine cleavage system
AWM74_RS00350	COG0772	Belongs to the SEDS family
AWM74_RS00355	COG1295	ribonuclease BN
AWM74_RS00405	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AWM74_RS00410	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AWM74_RS00415	COG0497	DNA recombination
AWM74_RS00420	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AWM74_RS00430	COG1722	exodeoxyribonuclease VII activity
AWM74_RS00435	COG1570	exodeoxyribonuclease VII activity
AWM74_RS00440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AWM74_RS00445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWM74_RS00455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AWM74_RS00460	COG0006	proline dipeptidase activity
AWM74_RS00485	COG4537	Required for transformation and DNA binding
AWM74_RS00490	COG1459	type II secretion system
AWM74_RS00495	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AWM74_RS00510	COG1269	ATP hydrolysis coupled proton transport
AWM74_RS00540	COG1394	ATPase activity, coupled to movement of substances
AWM74_RS00545	COG0217	transcriptional regulatory protein
AWM74_RS00550	COG1597	lipid kinase activity
AWM74_RS00555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWM74_RS00560	COG1063	alcohol dehydrogenase
AWM74_RS00565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWM74_RS00570	COG0656	L-ascorbic acid biosynthetic process
AWM74_RS00575	COG2848	UPF0210 protein
AWM74_RS00580	COG3830	Belongs to the UPF0237 family
AWM74_RS00585	COG2843	Capsule synthesis protein
AWM74_RS00605	COG0668	transmembrane transport
AWM74_RS00610	COG0622	Phosphoesterase
AWM74_RS00615	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AWM74_RS00630	COG3118	belongs to the thioredoxin family
AWM74_RS00635	COG1193	negative regulation of DNA recombination
AWM74_RS00650	COG0765	amino acid transport
AWM74_RS00670	COG2199	diguanylate cyclase activity
AWM74_RS00685	COG0179	Fumarylacetoacetate (FAA) hydrolase
AWM74_RS00690	COG1720	tRNA m6t6A37 methyltransferase activity
AWM74_RS00700	COG2176	DNA-directed DNA polymerase activity
AWM74_RS00705	COG1671	Belongs to the UPF0178 family
AWM74_RS00715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWM74_RS00720	COG0765	amino acid transport
AWM74_RS00725	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AWM74_RS00735	COG0561	phosphatase activity
AWM74_RS00750	COG1737	Transcriptional regulator
AWM74_RS00755	COG0673	inositol 2-dehydrogenase activity
AWM74_RS00760	COG0673	inositol 2-dehydrogenase activity
AWM74_RS00765	COG0584	glycerophosphoryl diester phosphodiesterase
AWM74_RS00770	COG3842	ATPase activity
AWM74_RS00780	COG1175	transmembrane transport
AWM74_RS00800	COG1764	response to oxidative stress
AWM74_RS00810	COG3158	transport of potassium into the cell
AWM74_RS00840	COG1304	FMN binding
AWM74_RS00845	COG0549	Belongs to the carbamate kinase family
AWM74_RS00855	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AWM74_RS00860	COG3257	ureidoglycine aminohydrolase activity
AWM74_RS00870	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AWM74_RS00875	COG1122	ATPase activity
AWM74_RS00880	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AWM74_RS00895	COG0802	atpase or kinase
AWM74_RS00900	COG0280	phosphate acetyltransferase
AWM74_RS00905	COG1070	Carbohydrate kinase
AWM74_RS00910	COG0072	phenylalanine-tRNA ligase activity
AWM74_RS00915	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AWM74_RS00920	COG1733	regulation of RNA biosynthetic process
AWM74_RS00930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWM74_RS00940	COG1187	pseudouridine synthase activity
AWM74_RS00945	COG2244	polysaccharide biosynthetic process
AWM74_RS00955	COG0495	leucyl-tRNA aminoacylation
AWM74_RS00960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AWM74_RS00970	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AWM74_RS00975	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM74_RS00975	COG1388	LysM domain
AWM74_RS00980	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AWM74_RS00990	COG1278	Cold shock
AWM74_RS00995	COG2003	Belongs to the UPF0758 family
AWM74_RS01000	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AWM74_RS01005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AWM74_RS01010	COG0285	dihydrofolate synthase activity
AWM74_RS01015	COG0525	valine-tRNA ligase activity
AWM74_RS01020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AWM74_RS01025	COG1940	carbohydrate kinase activity
AWM74_RS01030	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AWM74_RS01035	COG0457	Tetratricopeptide repeat
AWM74_RS01035	COG0705	Rhomboid family
AWM74_RS01040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AWM74_RS01045	COG0768	penicillin binding
AWM74_RS01055	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AWM74_RS01065	COG0513	Belongs to the DEAD box helicase family
AWM74_RS01070	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AWM74_RS01075	COG1744	ABC transporter substrate-binding protein PnrA-like
AWM74_RS01080	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AWM74_RS01085	COG4109	DRTGG domain
AWM74_RS01105	COG1862	Preprotein translocase
AWM74_RS01110	COG0343	queuine tRNA-ribosyltransferase activity
AWM74_RS01125	COG4864	UPF0365 protein
AWM74_RS01135	COG0542	response to heat
AWM74_RS01145	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AWM74_RS01155	COG0110	maltose O-acetyltransferase activity
AWM74_RS01170	COG0789	Transcriptional regulator
AWM74_RS01180	COG1733	regulation of RNA biosynthetic process
AWM74_RS01185	COG1937	Protein conserved in bacteria
AWM74_RS01190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AWM74_RS01195	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWM74_RS01210	COG1132	(ABC) transporter
AWM74_RS01225	COG0151	Belongs to the GarS family
AWM74_RS01230	COG0138	bifunctional purine biosynthesis protein purh
AWM74_RS01235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AWM74_RS01240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AWM74_RS01245	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AWM74_RS01250	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AWM74_RS01280	COG1070	Carbohydrate kinase
AWM74_RS01285	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AWM74_RS01290	COG2723	6-phospho-beta-galactosidase activity
AWM74_RS01295	COG1447	Phosphotransferase system cellobiose-specific component IIA
AWM74_RS01305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM74_RS01305	COG3711	transcriptional antiterminator
AWM74_RS01315	COG2723	6-phospho-beta-galactosidase activity
AWM74_RS01320	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AWM74_RS01325	COG0789	Transcriptional regulator
AWM74_RS01330	COG0667	Aldo Keto reductase
AWM74_RS01335	COG0673	inositol 2-dehydrogenase activity
AWM74_RS01345	COG0038	chloride channel
AWM74_RS01350	COG0335	large ribosomal subunit rRNA binding
AWM74_RS01355	COG0469	pyruvate kinase activity
AWM74_RS01365	COG0336	Belongs to the RNA methyltransferase TrmD family
AWM74_RS01375	COG1837	Belongs to the UPF0109 family
AWM74_RS01385	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AWM74_RS01390	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AWM74_RS01395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AWM74_RS01400	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
AWM74_RS01405	COG1940	carbohydrate kinase activity
AWM74_RS01410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWM74_RS01415	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AWM74_RS01420	COG4894	glucomannan catabolic process
AWM74_RS01430	COG0642	Histidine kinase
AWM74_RS01435	COG1136	(ABC) transporter
AWM74_RS01455	COG0552	protein localization to endoplasmic reticulum
AWM74_RS01460	COG0561	phosphatase activity
AWM74_RS01465	COG1196	nuclear chromosome segregation
AWM74_RS01470	COG0571	ribonuclease III activity
AWM74_RS01475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AWM74_RS01480	COG0416	fatty acid biosynthetic process
AWM74_RS01485	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AWM74_RS01490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM74_RS01515	COG0708	Exodeoxyribonuclease III
AWM74_RS01520	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AWM74_RS01525	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AWM74_RS01535	COG1263	PTS System
AWM74_RS01535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM74_RS01545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AWM74_RS01550	COG2723	6-phospho-beta-galactosidase activity
AWM74_RS01555	COG2188	Transcriptional regulator
AWM74_RS01575	COG1454	alcohol dehydrogenase
AWM74_RS01575	COG1012	belongs to the aldehyde dehydrogenase family
AWM74_RS01580	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AWM74_RS01585	COG1882	Formate acetyltransferase
AWM74_RS01590	COG2151	metal-sulfur cluster biosynthetic enzyme
AWM74_RS01655	COG1879	ABC-type sugar transport system periplasmic component
AWM74_RS01670	COG5039	Polysaccharide pyruvyl transferase
AWM74_RS01675	COG1216	Glycosyl transferase, family 2
AWM74_RS01680	COG0463	Glycosyl transferase, family 2
AWM74_RS01680	COG1216	Glycosyl transferase, family 2
AWM74_RS01695	COG0463	Glycosyl transferase, family 2
AWM74_RS01695	COG1216	Glycosyl transferase, family 2
AWM74_RS01710	COG1086	Polysaccharide biosynthesis protein
AWM74_RS01725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AWM74_RS01730	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AWM74_RS01735	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AWM74_RS01740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AWM74_RS01750	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AWM74_RS01765	COG1562	ergosterol biosynthetic process
AWM74_RS01780	COG1461	Dihydroxyacetone kinase
AWM74_RS01785	COG1302	Protein conserved in bacteria
AWM74_RS01790	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AWM74_RS01795	COG1564	THIamine pyrophosphokinase
AWM74_RS01800	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AWM74_RS01805	COG1162	GTPase activity
AWM74_RS01815	COG0631	protein serine/threonine phosphatase activity
AWM74_RS01820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWM74_RS01820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AWM74_RS01825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AWM74_RS01830	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AWM74_RS01835	COG0402	S-adenosylhomocysteine deaminase activity
AWM74_RS01840	COG1758	RNA polymerase activity
AWM74_RS01845	COG0194	GDP metabolic process
AWM74_RS01855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AWM74_RS01870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AWM74_RS01875	COG1185	polyribonucleotide nucleotidyltransferase activity
AWM74_RS01880	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AWM74_RS01885	COG0671	phosphoesterase, PA-phosphatase related
AWM74_RS01890	COG0556	nucleotide-excision repair
AWM74_RS01900	COG1466	dna polymerase III delta subunit
AWM74_RS01910	COG1555	photosystem II stabilization
AWM74_RS01910	COG1596	polysaccharide export
AWM74_RS01915	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AWM74_RS01920	COG0742	ribosomal rna small subunit methyltransferase
AWM74_RS01940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AWM74_RS01945	COG0783	Belongs to the Dps family
AWM74_RS01965	COG4471	UPF0298 protein
AWM74_RS01970	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AWM74_RS01975	COG1263	PTS System
AWM74_RS01975	COG2190	(PTS) system
AWM74_RS01975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM74_RS01985	COG0772	Belongs to the SEDS family
AWM74_RS01990	COG1217	gtp-binding protein TYPA
AWM74_RS01995	COG0483	inositol monophosphate 1-phosphatase activity
AWM74_RS02000	COG4476	Belongs to the UPF0223 family
AWM74_RS02005	COG1464	Belongs to the NlpA lipoprotein family
AWM74_RS02010	COG2207	Transcriptional regulator
AWM74_RS02010	COG1917	Cupin 2, conserved barrel domain protein
AWM74_RS02035	COG0673	inositol 2-dehydrogenase activity
AWM74_RS02045	COG0534	Mate efflux family protein
AWM74_RS02060	COG0022	dehydrogenase e1 component
AWM74_RS02070	COG0242	peptide deformylase activity
AWM74_RS02075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AWM74_RS02105	COG3425	synthase
AWM74_RS02110	COG1904	glucuronate isomerase
AWM74_RS02120	COG0800	Aldolase
AWM74_RS02130	COG1028	Short-chain dehydrogenase reductase Sdr
AWM74_RS02135	COG1312	Catalyzes the dehydration of D-mannonate
AWM74_RS02145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM74_RS02155	COG0765	amino acid transport
AWM74_RS02160	COG0765	amino acid transport
AWM74_RS02165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWM74_RS02210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AWM74_RS02230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AWM74_RS02245	COG1054	Belongs to the UPF0176 family
AWM74_RS02250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AWM74_RS02255	COG4120	Belongs to the binding-protein-dependent transport system permease family
AWM74_RS02270	COG1876	peptidase activity
AWM74_RS02275	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AWM74_RS02280	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AWM74_RS02285	COG0252	asparaginase activity
AWM74_RS02290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM74_RS02300	COG0489	protein tyrosine kinase activity
AWM74_RS02315	COG4464	protein tyrosine phosphatase activity
AWM74_RS02320	COG1051	belongs to the nudix hydrolase family
AWM74_RS02330	COG1307	EDD domain protein, DegV family
AWM74_RS02355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWM74_RS02360	COG1316	TRANSCRIPTIONal
AWM74_RS02365	COG1316	TRANSCRIPTIONal
AWM74_RS02370	COG0024	Methionine aminopeptidase
AWM74_RS02380	COG0716	FMN binding
AWM74_RS02385	COG2309	aminopeptidase activity
AWM74_RS02400	COG0463	Glycosyl transferase, family 2
AWM74_RS02420	COG1215	transferase activity, transferring glycosyl groups
AWM74_RS02435	COG0438	transferase activity, transferring glycosyl groups
AWM74_RS02435	COG0297	glycogen (starch) synthase activity
AWM74_RS02445	COG0297	glycogen (starch) synthase activity
AWM74_RS02455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWM74_RS02460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWM74_RS02465	COG1121	(ABC) transporter
AWM74_RS02470	COG3443	Belongs to the bacterial solute-binding protein 9 family
AWM74_RS02470	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWM74_RS02475	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AWM74_RS02480	COG4466	Protein conserved in bacteria
AWM74_RS02485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AWM74_RS02495	COG0084	hydrolase, TatD family'
AWM74_RS02500	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM74_RS02500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM74_RS02510	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AWM74_RS02520	COG2249	NAD(P)H dehydrogenase (quinone) activity
AWM74_RS02525	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AWM74_RS02550	COG2738	Putative neutral zinc metallopeptidase
AWM74_RS02570	COG1335	isochorismatase
AWM74_RS02575	COG0436	Aminotransferase
AWM74_RS02580	COG1522	sequence-specific DNA binding
AWM74_RS02595	COG1966	Carbon starvation protein
AWM74_RS02600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWM74_RS02615	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AWM74_RS02625	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AWM74_RS02630	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AWM74_RS02635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AWM74_RS02640	COG0569	domain protein
AWM74_RS02645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AWM74_RS02650	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AWM74_RS02660	COG4853	Protein conserved in bacteria
AWM74_RS02670	COG5002	protein histidine kinase activity
AWM74_RS02675	COG0745	RESPONSE REGULATOR receiver
AWM74_RS02695	COG1472	Belongs to the glycosyl hydrolase 3 family
AWM74_RS02700	COG1073	alpha beta
AWM74_RS02705	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWM74_RS02710	COG0628	permease
AWM74_RS02735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM74_RS02745	COG1028	Short-chain dehydrogenase reductase Sdr
AWM74_RS02750	COG0475	glutathione-regulated potassium exporter activity
AWM74_RS02755	COG0588	phosphoglycerate mutase activity
AWM74_RS02775	COG3527	Alpha-acetolactate decarboxylase
AWM74_RS02785	COG2040	homocysteine
AWM74_RS02790	COG0833	amino acid
AWM74_RS02810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AWM74_RS02815	COG4807	Protein conserved in bacteria
AWM74_RS02835	COG3684	Belongs to the aldolase LacD family
AWM74_RS02845	COG0698	ribose 5-phosphate isomerase
AWM74_RS02850	COG1105	Belongs to the carbohydrate kinase PfkB family
AWM74_RS02855	COG1349	DNA-binding transcription factor activity
AWM74_RS02860	COG3775	system Galactitol-specific IIC component
AWM74_RS02880	COG0753	catalase activity
AWM74_RS02885	COG1902	pentaerythritol trinitrate reductase activity
AWM74_RS02890	COG0640	Transcriptional regulator
AWM74_RS02905	COG1028	Short-chain dehydrogenase reductase Sdr
AWM74_RS02910	COG0110	maltose O-acetyltransferase activity
AWM74_RS02915	COG0583	DNA-binding transcription factor activity
AWM74_RS02920	COG0564	pseudouridine synthase activity
AWM74_RS02935	COG2723	6-phospho-beta-galactosidase activity
AWM74_RS02940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AWM74_RS02950	COG2188	Transcriptional regulator
AWM74_RS02960	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AWM74_RS02965	COG1447	Phosphotransferase system cellobiose-specific component IIA
AWM74_RS02990	COG0159	tryptophan synthase activity
AWM74_RS02995	COG0133	tryptophan synthase activity
AWM74_RS03005	COG0134	indole-3-glycerol-phosphate synthase activity
AWM74_RS03010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AWM74_RS03015	COG0512	Glutamine amidotransferase of anthranilate synthase
AWM74_RS03015	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AWM74_RS03060	COG4895	conserved protein (DUF2196)
AWM74_RS03065	COG2873	o-acetylhomoserine
AWM74_RS03070	COG1959	2 iron, 2 sulfur cluster binding
AWM74_RS03085	COG2321	neutral zinc metallopeptidase
AWM74_RS03100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWM74_RS03105	COG2207	Transcriptional regulator
AWM74_RS03105	COG3708	Transcriptional regulator
AWM74_RS03135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AWM74_RS03140	COG0583	DNA-binding transcription factor activity
AWM74_RS03145	COG1380	Effector of murein hydrolase LrgA
AWM74_RS03150	COG1346	cytolysis
AWM74_RS03155	COG1304	FMN binding
AWM74_RS03180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AWM74_RS03185	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AWM74_RS03190	COG0154	amidase activity
AWM74_RS03195	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AWM74_RS03200	COG4851	CamS sex pheromone cAM373 precursor
AWM74_RS03205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AWM74_RS03210	COG0210	DNA helicase
AWM74_RS03220	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWM74_RS03265	COG0737	Belongs to the 5'-nucleotidase family
AWM74_RS03280	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AWM74_RS03285	COG1960	acyl-CoA dehydrogenase activity
AWM74_RS03295	COG2801	Transposase and inactivated derivatives
AWM74_RS03315	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AWM74_RS03325	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AWM74_RS03335	COG3850	Histidine kinase
AWM74_RS03335	COG5002	protein histidine kinase activity
AWM74_RS03340	COG0745	RESPONSE REGULATOR receiver
AWM74_RS03345	COG0629	single-stranded DNA binding
AWM74_RS03355	COG1481	regulation of sporulation
AWM74_RS03365	COG1660	Displays ATPase and GTPase activities
AWM74_RS03370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWM74_RS03375	COG0492	ferredoxin-NADP+ reductase activity
AWM74_RS03380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AWM74_RS03385	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AWM74_RS03390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AWM74_RS03405	COG1983	PspC domain protein
AWM74_RS03420	COG0419	ATPase involved in DNA repair
AWM74_RS03430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AWM74_RS03435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AWM74_RS03440	COG0581	inorganic phosphate transmembrane transporter activity
AWM74_RS03445	COG0573	inorganic phosphate transmembrane transporter activity
AWM74_RS03450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AWM74_RS03455	COG5002	protein histidine kinase activity
AWM74_RS03460	COG0745	RESPONSE REGULATOR receiver
AWM74_RS03465	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AWM74_RS03470	COG0653	protein targeting
AWM74_RS03485	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AWM74_RS03490	COG1307	EDD domain protein, DegV family
AWM74_RS03495	COG1739	Uncharacterized protein family UPF0029
AWM74_RS03500	COG0277	FAD linked oxidase domain protein
AWM74_RS03520	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AWM74_RS03525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AWM74_RS03535	COG0765	amino acid transport
AWM74_RS03540	COG0431	NADPH-dependent FMN reductase
AWM74_RS03550	COG0765	amino acid transport
AWM74_RS03555	COG0165	Argininosuccinate lyase
AWM74_RS03565	COG0459	protein refolding
AWM74_RS03585	COG0488	(ABC) transporter
AWM74_RS03600	COG0183	Belongs to the thiolase family
AWM74_RS03605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWM74_RS03675	COG1394	ATPase activity, coupled to movement of substances
AWM74_RS03680	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
AWM74_RS03685	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AWM74_RS03690	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
AWM74_RS03695	COG1527	subunit (C
AWM74_RS03705	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AWM74_RS03710	COG1269	ATP hydrolysis coupled proton transport
AWM74_RS03720	COG0590	tRNA wobble adenosine to inosine editing
AWM74_RS03725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM74_RS03725	COG1263	PTS System
AWM74_RS03730	COG0366	Alpha amylase catalytic
AWM74_RS03745	COG2188	Transcriptional regulator
AWM74_RS03755	COG0077	Prephenate dehydratase
AWM74_RS03765	COG0542	response to heat
AWM74_RS03770	COG4463	regulation of RNA biosynthetic process
AWM74_RS03775	COG0473	3-isopropylmalate dehydrogenase activity
AWM74_RS03780	COG2851	Citrate transporter
AWM74_RS03825	COG1131	(ABC) transporter
AWM74_RS03840	COG1940	carbohydrate kinase activity
AWM74_RS03850	COG0058	SHG alpha-glucan phosphorylase activity
AWM74_RS03855	COG1640	4-alpha-glucanotransferase
AWM74_RS03860	COG1609	Transcriptional regulator
AWM74_RS03865	COG0673	inositol 2-dehydrogenase activity
AWM74_RS03880	COG0673	inositol 2-dehydrogenase activity
AWM74_RS03885	COG3842	ATPase activity
AWM74_RS03895	COG3833	ABC-type maltose transport systems, permease component
AWM74_RS03900	COG1175	transmembrane transport
AWM74_RS03905	COG2182	Extracellular solute-binding protein
AWM74_RS03915	COG1263	PTS System
AWM74_RS03915	COG2190	(PTS) system
AWM74_RS03915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM74_RS03930	COG1737	Transcriptional regulator
AWM74_RS03935	COG1486	melibiose metabolic process
AWM74_RS03940	COG1263	PTS System
AWM74_RS03940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM74_RS03950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AWM74_RS03980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AWM74_RS03985	COG0456	acetyltransferase
AWM74_RS03990	COG0456	acetyltransferase
AWM74_RS03995	COG1214	PFAM Peptidase M22, glycoprotease
AWM74_RS04000	COG2211	Major facilitator Superfamily
AWM74_RS04005	COG0346	lactoylglutathione lyase activity
AWM74_RS04010	COG0400	carboxylic ester hydrolase activity
AWM74_RS04015	COG4224	UPF0291 protein
AWM74_RS04020	COG2723	6-phospho-beta-galactosidase activity
AWM74_RS04025	COG1263	PTS System
AWM74_RS04025	COG2190	(PTS) system
AWM74_RS04025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM74_RS04035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AWM74_RS04045	COG0440	acetolactate synthase activity
AWM74_RS04050	COG0028	Belongs to the TPP enzyme family
AWM74_RS04055	COG1119	ATPase activity
AWM74_RS04065	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AWM74_RS04085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AWM74_RS04095	COG0561	phosphatase activity
AWM74_RS04100	COG0366	Alpha amylase catalytic
AWM74_RS04105	COG2252	PERMEase
AWM74_RS04110	COG1304	FMN binding
AWM74_RS04115	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AWM74_RS04125	COG2226	methyltransferase
AWM74_RS04140	COG1028	Short-chain dehydrogenase reductase Sdr
AWM74_RS04150	COG1464	Belongs to the NlpA lipoprotein family
AWM74_RS04155	COG0436	Aminotransferase
AWM74_RS04160	COG0246	Mannitol dehydrogenase
AWM74_RS04165	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM74_RS04170	COG3711	transcriptional antiterminator
AWM74_RS04175	COG2213	PTS system mannitol-specific
AWM74_RS04180	COG0363	glucosamine-6-phosphate deaminase activity
AWM74_RS04185	COG1028	Short-chain dehydrogenase reductase Sdr
AWM74_RS04190	COG2323	membrane
AWM74_RS04195	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AWM74_RS04215	COG1187	pseudouridine synthase activity
AWM74_RS04230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWM74_RS04240	COG1695	Transcriptional regulator
AWM74_RS04245	COG0789	Transcriptional regulator
AWM74_RS04250	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AWM74_RS04260	COG1302	Protein conserved in bacteria
AWM74_RS04280	COG1486	melibiose metabolic process
AWM74_RS04285	COG1737	Transcriptional regulator
AWM74_RS04300	COG0626	cystathionine gamma-synthase activity
AWM74_RS04305	COG2514	catechol 2,3-dioxygenase activity
AWM74_RS04315	COG0039	L-malate dehydrogenase activity
AWM74_RS04320	COG0589	response to stress
AWM74_RS04330	COG1363	Peptidase, m42
AWM74_RS04400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AWM74_RS04405	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AWM74_RS04420	COG0745	RESPONSE REGULATOR receiver
AWM74_RS04425	COG0517	IMP dehydrogenase activity
AWM74_RS04425	COG0516	GMP reductase activity
AWM74_RS04445	COG0012	GTP binding
AWM74_RS04450	COG4481	Protein conserved in bacteria
AWM74_RS04455	COG1475	DNA binding
AWM74_RS04460	COG1192	Involved in chromosome partitioning
AWM74_RS04465	COG0357	Ribosomal RNA small subunit methyltransferase G
AWM74_RS04475	COG0445	tRNA wobble uridine modification
AWM74_RS04480	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AWM74_RS04490	COG0668	transmembrane transport
AWM74_RS04495	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM74_RS04500	COG3711	transcriptional antiterminator
AWM74_RS04505	COG2213	PTS system mannitol-specific
AWM74_RS04510	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AWM74_RS04515	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AWM74_RS04520	COG1847	R3H domain protein
AWM74_RS04525	COG0706	membrane insertase activity
AWM74_RS04545	COG0592	DNA-directed DNA polymerase activity
AWM74_RS04550	COG2501	S4 domain
AWM74_RS04555	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AWM74_RS04560	COG0187	DNA topoisomerase II activity
AWM74_RS04565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWM74_RS04570	COG0360	Binds together with S18 to 16S ribosomal RNA
AWM74_RS04575	COG0629	single-stranded DNA binding
AWM74_RS04580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AWM74_RS04585	COG0346	lactoylglutathione lyase activity
AWM74_RS04590	COG0371	Dehydrogenase
AWM74_RS04595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWM74_RS04605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWM74_RS04610	COG0601	transmembrane transport
AWM74_RS04615	COG4608	Belongs to the ABC transporter superfamily
AWM74_RS04630	COG0359	binds to the 23S rRNA
AWM74_RS04635	COG0305	Participates in initiation and elongation during chromosome replication
AWM74_RS04650	COG2217	Heavy metal translocating P-type atpase
AWM74_RS04665	COG1122	ATPase activity
AWM74_RS04675	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AWM74_RS04685	COG0693	protein deglycase activity
AWM74_RS04690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM74_RS04695	COG2190	(PTS) system
AWM74_RS04695	COG1263	PTS System
AWM74_RS04695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM74_RS04700	COG1428	Deoxynucleoside kinase
AWM74_RS04715	COG0596	Alpha beta hydrolase
AWM74_RS04730	COG1346	cytolysis
AWM74_RS04735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWM74_RS04745	COG1418	mRNA catabolic process
AWM74_RS04750	COG1428	Deoxynucleoside kinase
AWM74_RS04755	COG0602	queuosine metabolic process
AWM74_RS04775	COG2151	metal-sulfur cluster biosynthetic enzyme
AWM74_RS04780	COG2217	Heavy metal translocating P-type atpase
AWM74_RS04785	COG1461	Dihydroxyacetone kinase
AWM74_RS04790	COG2376	Dihydroxyacetone kinase
AWM74_RS04795	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AWM74_RS04800	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AWM74_RS04805	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AWM74_RS04810	COG0789	Transcriptional regulator
AWM74_RS04830	COG3715	PTS system
AWM74_RS04835	COG3716	PTS system mannose fructose sorbose family IID component
AWM74_RS04845	COG1482	cell wall glycoprotein biosynthetic process
AWM74_RS04850	COG2116	formate transmembrane transporter activity
AWM74_RS04865	COG1136	(ABC) transporter
AWM74_RS04895	COG1496	oxidoreductase activity
AWM74_RS04920	COG0756	dUTP diphosphatase activity
AWM74_RS04925	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AWM74_RS04930	COG4956	integral membrane protein (PIN domain superfamily)
AWM74_RS04935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AWM74_RS04950	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AWM74_RS04960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWM74_RS04965	COG2233	PERMEase
AWM74_RS04975	COG1174	glycine betaine transport
AWM74_RS04980	COG0517	IMP dehydrogenase activity
AWM74_RS04980	COG1125	glycine betaine transport
AWM74_RS04985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AWM74_RS04990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AWM74_RS04995	COG1464	Belongs to the NlpA lipoprotein family
AWM74_RS05000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM74_RS05010	COG3037	sugar-specific permease SgaT UlaA
AWM74_RS05015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AWM74_RS05025	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AWM74_RS05030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWM74_RS05045	COG2610	gluconate transmembrane transporter activity
AWM74_RS05055	COG0250	Participates in transcription elongation, termination and antitermination
AWM74_RS05065	COG0704	Plays a role in the regulation of phosphate uptake
AWM74_RS05075	COG0081	regulation of translation
AWM74_RS05085	COG0222	ribosome binding
AWM74_RS05090	COG1028	Short-chain dehydrogenase reductase Sdr
AWM74_RS05100	COG0765	amino acid transport
AWM74_RS05105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWM74_RS05115	COG1121	(ABC) transporter
AWM74_RS05120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWM74_RS05125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWM74_RS05135	COG2723	6-phospho-beta-galactosidase activity
AWM74_RS05145	COG2190	(PTS) system
AWM74_RS05145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM74_RS05145	COG1263	PTS System
AWM74_RS05150	COG2723	6-phospho-beta-galactosidase activity
AWM74_RS05155	COG2813	Specifically methylates the guanine in position
AWM74_RS05160	COG3448	diguanylate cyclase activity
AWM74_RS05160	COG4175	Glycine betaine
AWM74_RS05180	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWM74_RS05190	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AWM74_RS05225	COG1653	transport
AWM74_RS05235	COG0395	ABC-type sugar transport system, permease component
AWM74_RS05240	COG3842	ATPase activity
AWM74_RS05245	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AWM74_RS05250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AWM74_RS05255	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AWM74_RS05260	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AWM74_RS05265	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AWM74_RS05275	COG0470	DNA polymerase III
AWM74_RS05280	COG1396	sequence-specific DNA binding
AWM74_RS05300	COG1131	(ABC) transporter
AWM74_RS05335	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AWM74_RS05335	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AWM74_RS05345	COG4467	Involved in initiation control of chromosome replication
AWM74_RS05350	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AWM74_RS05355	COG2827	Endonuclease containing a URI domain
AWM74_RS05360	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AWM74_RS05370	COG1970	mechanosensitive ion channel activity
AWM74_RS05375	COG2079	MmgE PrpD family protein
AWM74_RS05385	COG0372	Belongs to the citrate synthase family
AWM74_RS05390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWM74_RS05400	COG0436	Aminotransferase
AWM74_RS05405	COG2814	Major facilitator Superfamily
AWM74_RS05410	COG1078	dGTPase activity
AWM74_RS05415	COG0095	Lipoate-protein ligase
AWM74_RS05425	COG3343	RNA polymerase activity
AWM74_RS05430	COG0504	CTP synthase activity
AWM74_RS05440	COG0284	orotidine-5'-phosphate decarboxylase activity
AWM74_RS05450	COG2814	Major facilitator Superfamily
AWM74_RS05455	COG2832	Protein of unknown function (DUF454)
AWM74_RS05480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AWM74_RS05485	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AWM74_RS05490	COG0254	rRNA binding
AWM74_RS05495	COG0251	oxidation-reduction process
AWM74_RS05500	COG0456	acetyltransferase
AWM74_RS05505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AWM74_RS05515	COG3764	Sortase (surface protein transpeptidase)
AWM74_RS05530	COG1181	Belongs to the D-alanine--D-alanine ligase family
AWM74_RS05535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AWM74_RS05555	COG1174	glycine betaine transport
AWM74_RS05570	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AWM74_RS05575	COG4708	membrane
AWM74_RS05580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWM74_RS05595	COG1253	flavin adenine dinucleotide binding
AWM74_RS05600	COG4122	O-methyltransferase activity
AWM74_RS05635	COG2326	polyphosphate kinase activity
AWM74_RS05640	COG0288	reversible hydration of carbon dioxide
AWM74_RS05645	COG4290	ribonuclease
AWM74_RS05650	COG2732	(Barnase) inhibitor
AWM74_RS05675	COG0322	excinuclease ABC activity
AWM74_RS05680	COG1408	metallophosphoesterase
AWM74_RS05685	COG0513	Belongs to the DEAD box helicase family
AWM74_RS05695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AWM74_RS05705	COG0039	L-malate dehydrogenase activity
AWM74_RS05710	COG0193	aminoacyl-tRNA hydrolase activity
AWM74_RS05715	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AWM74_RS05720	COG2244	polysaccharide biosynthetic process
AWM74_RS05725	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AWM74_RS05735	COG1098	S1 RNA binding domain
AWM74_RS05740	COG0037	tRNA processing
AWM74_RS05745	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AWM74_RS05750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AWM74_RS05755	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AWM74_RS05765	COG0640	Transcriptional regulator
AWM74_RS05770	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AWM74_RS05775	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AWM74_RS05780	COG0049	tRNA binding
AWM74_RS05785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AWM74_RS05790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AWM74_RS05800	COG1122	ATPase activity
AWM74_RS05820	COG0051	transcription antitermination factor activity, RNA binding
AWM74_RS05825	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AWM74_RS05830	COG0088	Forms part of the polypeptide exit tunnel
AWM74_RS05835	COG0089	rRNA binding
AWM74_RS05850	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AWM74_RS05855	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AWM74_RS05860	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AWM74_RS05865	COG0255	Belongs to the universal ribosomal protein uL29 family
AWM74_RS05870	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AWM74_RS05875	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AWM74_RS05880	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AWM74_RS05890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AWM74_RS05895	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AWM74_RS05900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AWM74_RS05905	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AWM74_RS05910	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AWM74_RS05915	COG1841	ribosomal large subunit assembly
AWM74_RS05930	COG0563	adenylate kinase activity
AWM74_RS05940	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AWM74_RS05945	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AWM74_RS05950	COG0202	RNA polymerase activity
AWM74_RS05955	COG0203	ribosomal protein L17
AWM74_RS05960	COG2755	lipolytic protein G-D-S-L family
AWM74_RS05960	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AWM74_RS05970	COG1122	ATPase activity
AWM74_RS05975	COG1122	ATPase activity
AWM74_RS05995	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AWM74_RS06015	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AWM74_RS06020	COG0583	DNA-binding transcription factor activity
AWM74_RS06025	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AWM74_RS06030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AWM74_RS06045	COG0662	Cupin 2, conserved barrel domain protein
AWM74_RS06050	COG1942	4-Oxalocrotonate Tautomerase
AWM74_RS06075	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AWM74_RS06075	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AWM74_RS06090	COG1442	glycosyl transferase family 8
AWM74_RS06095	COG2188	Transcriptional regulator
AWM74_RS06105	COG2190	(PTS) system
AWM74_RS06105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM74_RS06105	COG1263	PTS System
AWM74_RS06120	COG1309	transcriptional regulator
AWM74_RS06140	COG2723	6-phospho-beta-galactosidase activity
AWM74_RS06150	COG1733	regulation of RNA biosynthetic process
AWM74_RS06160	COG3339	Conserved Protein
AWM74_RS06175	COG0352	thiamine-phosphate diphosphorylase activity
AWM74_RS06180	COG0351	phosphomethylpyrimidine kinase
AWM74_RS06190	COG2610	gluconate transmembrane transporter activity
AWM74_RS06195	COG1929	Belongs to the glycerate kinase type-1 family
AWM74_RS06200	COG3835	regulator
AWM74_RS06220	COG4608	Belongs to the ABC transporter superfamily
AWM74_RS06240	COG1725	Transcriptional regulator
AWM74_RS06245	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AWM74_RS06250	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AWM74_RS06255	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AWM74_RS06260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AWM74_RS06265	COG0131	Imidazoleglycerol-phosphate dehydratase
AWM74_RS06270	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AWM74_RS06275	COG0107	imidazoleglycerol-phosphate synthase activity
AWM74_RS06280	COG0140	phosphoribosyl-ATP diphosphatase activity
AWM74_RS06280	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AWM74_RS06285	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AWM74_RS06300	COG2188	Transcriptional regulator
AWM74_RS06305	COG0386	Belongs to the glutathione peroxidase family
AWM74_RS06310	COG3443	Belongs to the bacterial solute-binding protein 9 family
AWM74_RS06310	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWM74_RS06330	COG0656	L-ascorbic acid biosynthetic process
AWM74_RS06350	COG0702	epimerase
AWM74_RS06355	COG4708	membrane
AWM74_RS06370	COG2217	Heavy metal translocating P-type atpase
AWM74_RS06380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWM74_RS06390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM74_RS06395	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AWM74_RS06400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM74_RS06405	COG1126	abc transporter atp-binding protein
AWM74_RS06410	COG0765	amino acid transport
AWM74_RS06415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWM74_RS06420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM74_RS06425	COG4565	transcriptional regulatory protein
AWM74_RS06430	COG3290	protein histidine kinase activity
AWM74_RS06435	COG3493	citrate carrier protein
AWM74_RS06445	COG4166	transmembrane transport
AWM74_RS06460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AWM74_RS06485	COG2137	regulation of response to DNA damage stimulus
AWM74_RS06490	COG1194	a g-specific adenine glycosylase
AWM74_RS06495	COG3557	Belongs to the UPF0374 family
AWM74_RS06505	COG1523	belongs to the glycosyl hydrolase 13 family
AWM74_RS06510	COG4129	membrane
AWM74_RS06515	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AWM74_RS06525	COG4989	oxidoreductase activity
AWM74_RS06640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWM74_RS06645	COG1464	Belongs to the NlpA lipoprotein family
AWM74_RS06650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AWM74_RS06655	COG0406	alpha-ribazole phosphatase activity
AWM74_RS06660	COG2723	6-phospho-beta-galactosidase activity
AWM74_RS06665	COG2188	Transcriptional regulator
AWM74_RS06670	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AWM74_RS06685	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AWM74_RS06690	COG0667	Aldo Keto reductase
AWM74_RS06695	COG0561	phosphatase activity
AWM74_RS06705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWM74_RS06710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM74_RS06710	COG2190	(PTS) system
AWM74_RS06710	COG1263	PTS System
AWM74_RS06715	COG2723	6-phospho-beta-galactosidase activity
AWM74_RS06740	COG2011	ABC-type metal ion transport system permease component
AWM74_RS06745	COG1464	Belongs to the NlpA lipoprotein family
AWM74_RS06750	COG0431	NADPH-dependent FMN reductase
AWM74_RS06755	COG0454	-acetyltransferase
AWM74_RS06760	COG0765	amino acid transport
AWM74_RS06765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWM74_RS06770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWM74_RS06775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWM74_RS06780	COG0765	amino acid transport
AWM74_RS06785	COG1126	abc transporter atp-binding protein
AWM74_RS06790	COG0686	Belongs to the AlaDH PNT family
AWM74_RS06795	COG3949	Membrane
AWM74_RS06805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AWM74_RS06815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWM74_RS06820	COG3679	Belongs to the UPF0342 family
AWM74_RS06825	COG0420	3'-5' exonuclease activity
AWM74_RS06830	COG4717	serine-type aminopeptidase activity
AWM74_RS06835	COG3481	metal-dependent phosphohydrolase, HD sub domain
AWM74_RS06845	COG0737	Belongs to the 5'-nucleotidase family
AWM74_RS06850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AWM74_RS06860	COG0537	adenosine 5'-monophosphoramidase activity
AWM74_RS06865	COG1131	(ABC) transporter
AWM74_RS06870	COG4473	ABC transporter
AWM74_RS06880	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AWM74_RS06890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWM74_RS06900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AWM74_RS06915	COG1785	Belongs to the alkaline phosphatase family
AWM74_RS06935	COG1573	uracil-dna glycosylase
AWM74_RS06940	COG2270	Major facilitator Superfamily
AWM74_RS06945	COG0435	Glutathione S-transferase
AWM74_RS06955	COG0302	gtp cyclohydrolase
AWM74_RS06960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AWM74_RS06965	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AWM74_RS06970	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AWM74_RS06975	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AWM74_RS06980	COG0406	alpha-ribazole phosphatase activity
AWM74_RS06985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWM74_RS06995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWM74_RS06995	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWM74_RS07000	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AWM74_RS07010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AWM74_RS07020	COG1484	DNA-dependent DNA replication
AWM74_RS07035	COG1302	Protein conserved in bacteria
AWM74_RS07040	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AWM74_RS07050	COG2818	Glycosylase
AWM74_RS07055	COG1464	Belongs to the NlpA lipoprotein family
AWM74_RS07065	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AWM74_RS07075	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AWM74_RS07080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AWM74_RS07085	COG2011	ABC-type metal ion transport system permease component
AWM74_RS07090	COG1464	Belongs to the NlpA lipoprotein family
AWM74_RS07100	COG0095	Lipoate-protein ligase
AWM74_RS07105	COG4862	establishment of competence for transformation
AWM74_RS07110	COG1393	Belongs to the ArsC family
AWM74_RS07115	COG0180	Tryptophanyl-tRNA synthetase
AWM74_RS07140	COG2357	RelA SpoT domain protein
AWM74_RS07150	COG0564	pseudouridine synthase activity
AWM74_RS07155	COG2239	Acts as a magnesium transporter
AWM74_RS07165	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AWM74_RS07170	COG0105	UTP biosynthetic process
AWM74_RS07175	COG0625	glutathione transferase activity
AWM74_RS07190	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AWM74_RS07195	COG0583	DNA-binding transcription factor activity
AWM74_RS07205	COG0542	response to heat
AWM74_RS07210	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM74_RS07220	COG0438	transferase activity, transferring glycosyl groups
AWM74_RS07225	COG4703	Protein of unknown function (DUF1797)
AWM74_RS07230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AWM74_RS07235	COG0460	homoserine dehydrogenase
AWM74_RS07240	COG0083	homoserine kinase activity
AWM74_RS07245	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AWM74_RS07250	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AWM74_RS07255	COG1534	Rna-binding protein
AWM74_RS07260	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AWM74_RS07270	COG0799	negative regulation of ribosome biogenesis
AWM74_RS07275	COG2226	methyltransferase
AWM74_RS07280	COG1323	Belongs to the UPF0348 family
AWM74_RS07285	COG1399	metal-binding, possibly nucleic acid-binding protein
AWM74_RS07300	COG2001	Belongs to the MraZ family
AWM74_RS07315	COG0768	penicillin binding
AWM74_RS07320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AWM74_RS07325	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AWM74_RS07330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AWM74_RS07335	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AWM74_RS07340	COG0849	cell division
AWM74_RS07350	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AWM74_RS07365	COG2302	S4 RNA-binding domain
AWM74_RS07370	COG3599	regulation of cell shape
AWM74_RS07375	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AWM74_RS07385	COG2261	transglycosylase associated protein
AWM74_RS07390	COG3853	Toxic anion resistance protein (TelA)
AWM74_RS07400	COG0494	nUDIX hydrolase
AWM74_RS07415	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AWM74_RS07420	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AWM74_RS07430	COG1104	cysteine desulfurase activity
AWM74_RS07435	COG0301	tRNA thio-modification
AWM74_RS07440	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AWM74_RS07450	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AWM74_RS07455	COG0745	RESPONSE REGULATOR receiver
AWM74_RS07465	COG0110	maltose O-acetyltransferase activity
AWM74_RS07470	COG0028	Belongs to the TPP enzyme family
AWM74_RS07475	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AWM74_RS07480	COG0706	membrane insertase activity
AWM74_RS07485	COG1254	Belongs to the acylphosphatase family
AWM74_RS07495	COG1674	ftsk spoiiie
AWM74_RS07495	COG1280	lysine exporter protein (LysE YggA)
AWM74_RS07500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AWM74_RS07510	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AWM74_RS07540	COG2190	(PTS) system
AWM74_RS07540	COG1263	PTS System
AWM74_RS07540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM74_RS07545	COG2723	6-phospho-beta-galactosidase activity
AWM74_RS07560	COG1914	H( )-stimulated, divalent metal cation uptake system
AWM74_RS07565	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AWM74_RS07570	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AWM74_RS07585	COG2255	four-way junction helicase activity
AWM74_RS07590	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AWM74_RS07595	COG0587	DNA-directed DNA polymerase activity
AWM74_RS07600	COG0205	6-phosphofructokinase activity
AWM74_RS07610	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AWM74_RS07620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AWM74_RS07625	COG2996	Protein conserved in bacteria
AWM74_RS07635	COG4152	abc transporter atp-binding protein
AWM74_RS07640	COG1668	transmembrane transport
AWM74_RS07645	COG0456	acetyltransferase
AWM74_RS07650	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AWM74_RS07655	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AWM74_RS07660	COG1187	pseudouridine synthase activity
AWM74_RS07665	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AWM74_RS07675	COG0514	ATP-dependent DNA helicase (RecQ)
AWM74_RS07685	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AWM74_RS07690	COG0539	negative regulation of cytoplasmic translation
AWM74_RS07695	COG1160	GTP binding
AWM74_RS07710	COG1621	beta-fructofuranosidase activity
AWM74_RS07715	COG1609	Transcriptional regulator
AWM74_RS07730	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AWM74_RS07735	COG0617	tRNA 3'-terminal CCA addition
AWM74_RS07740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AWM74_RS07740	COG1199	ATP-dependent helicase activity
AWM74_RS07760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AWM74_RS07765	COG1846	Transcriptional regulator
AWM74_RS07770	COG0737	Belongs to the 5'-nucleotidase family
AWM74_RS07775	COG4470	Protein conserved in bacteria
AWM74_RS07780	COG0647	UMP catabolic process
AWM74_RS07790	COG0492	ferredoxin-NADP+ reductase activity
AWM74_RS07795	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AWM74_RS07800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AWM74_RS07805	COG1098	S1 RNA binding domain
AWM74_RS07810	COG0166	Belongs to the GPI family
AWM74_RS07945	COG1792	Involved in formation and maintenance of cell shape
AWM74_RS07955	COG0765	amino acid transport
AWM74_RS07960	COG1126	abc transporter atp-binding protein
AWM74_RS07970	COG2868	ribosomal protein
AWM74_RS07985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AWM74_RS07995	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AWM74_RS08000	COG1263	PTS System
AWM74_RS08000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWM74_RS08005	COG1737	Transcriptional regulator
AWM74_RS08030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AWM74_RS08040	COG1104	cysteine desulfurase activity
AWM74_RS08050	COG0482	sulfurtransferase activity
AWM74_RS08055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AWM74_RS08060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AWM74_RS08065	COG4472	Bacterial protein of unknown function (DUF965)
AWM74_RS08070	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AWM74_RS08075	COG3906	Belongs to the UPF0473 family
AWM74_RS08080	COG1959	2 iron, 2 sulfur cluster binding
AWM74_RS08085	COG1511	domain protein
AWM74_RS08090	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AWM74_RS08100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AWM74_RS08115	COG2197	response regulator
AWM74_RS08120	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AWM74_RS08125	COG5503	Protein of unknown function (DUF1447)
AWM74_RS08130	COG4129	membrane
AWM74_RS08135	COG1272	protein, Hemolysin III
AWM74_RS08150	COG1307	EDD domain protein, DegV family
AWM74_RS08170	COG4619	ABC transporter
AWM74_RS08175	COG0390	transport system, permease component
AWM74_RS08185	COG1072	(Pantothenic acid kinase))
AWM74_RS08190	COG0628	permease
AWM74_RS08195	COG1132	(ABC) transporter
AWM74_RS08200	COG1132	(ABC) transporter
AWM74_RS08205	COG0488	(ABC) transporter
AWM74_RS08210	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AWM74_RS08220	COG0561	phosphatase activity
AWM74_RS08225	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AWM74_RS08230	COG3682	Transcriptional regulator
AWM74_RS08235	COG1780	Probably involved in ribonucleotide reductase function
AWM74_RS08240	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AWM74_RS08250	COG2267	carboxylic ester hydrolase activity
AWM74_RS08255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWM74_RS08260	COG3331	DNA recombination
AWM74_RS08265	COG0544	peptidyl-prolyl cis-trans isomerase activity
AWM74_RS08270	COG1957	nucleoside hydrolase
AWM74_RS08275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AWM74_RS08280	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AWM74_RS08285	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AWM74_RS08290	COG0358	DNA primase activity
AWM74_RS08295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AWM74_RS08310	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AWM74_RS08315	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AWM74_RS08320	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AWM74_RS08325	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AWM74_RS08330	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AWM74_RS08335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AWM74_RS08340	COG0488	(ABC) transporter
AWM74_RS08360	COG2384	SAM-dependent methyltransferase
AWM74_RS08365	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AWM74_RS08370	COG2195	Cleaves the N-terminal amino acid of tripeptides
AWM74_RS08375	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AWM74_RS08380	COG1074	ATP-dependent DNA helicase activity
AWM74_RS08390	COG3341	Caulimovirus viroplasmin
AWM74_RS08390	COG0328	RNA-DNA hybrid ribonuclease activity
AWM74_RS08395	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AWM74_RS08400	COG0564	pseudouridine synthase activity
AWM74_RS08405	COG3763	UPF0154 protein
AWM74_RS08410	COG1132	(ABC) transporter
AWM74_RS08415	COG1132	(ABC) transporter
AWM74_RS08420	COG0204	Acyl-transferase
AWM74_RS08425	COG0628	permease
AWM74_RS08435	COG0052	Belongs to the universal ribosomal protein uS2 family
AWM74_RS08440	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AWM74_RS08445	COG0528	UMP kinase activity
AWM74_RS08450	COG0233	cytoplasmic translational termination
AWM74_RS08455	COG5002	protein histidine kinase activity
AWM74_RS08460	COG0745	RESPONSE REGULATOR receiver
AWM74_RS08480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AWM74_RS08485	COG4589	Belongs to the CDS family
AWM74_RS08490	COG0750	zinc metalloprotease
AWM74_RS08495	COG2176	DNA-directed DNA polymerase activity
AWM74_RS08510	COG0779	Required for maturation of 30S ribosomal subunits
AWM74_RS08515	COG0195	Participates in both transcription termination and antitermination
AWM74_RS08520	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AWM74_RS08535	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AWM74_RS08545	COG3759	membrane
AWM74_RS08555	COG0740	serine-type endopeptidase activity
AWM74_RS08580	COG0149	triose-phosphate isomerase activity
AWM74_RS08585	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AWM74_RS08590	COG0148	phosphopyruvate hydratase activity
AWM74_RS08595	COG4166	transmembrane transport
AWM74_RS08600	COG4166	transmembrane transport
AWM74_RS08610	COG0601	transmembrane transport
AWM74_RS08615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWM74_RS08620	COG0444	Belongs to the ABC transporter superfamily
AWM74_RS08625	COG4608	Belongs to the ABC transporter superfamily
AWM74_RS08640	COG0557	exoribonuclease II activity
AWM74_RS08645	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AWM74_RS08650	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AWM74_RS08655	COG0588	phosphoglycerate mutase activity
AWM74_RS08675	COG0402	S-adenosylhomocysteine deaminase activity
AWM74_RS08715	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AWM74_RS08725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AWM74_RS08735	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AWM74_RS08740	COG0439	Biotin carboxylase
AWM74_RS08745	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AWM74_RS08765	COG0116	Belongs to the methyltransferase superfamily
AWM74_RS08775	COG3599	regulation of cell shape
AWM74_RS08785	COG2264	protein methyltransferase activity
AWM74_RS08790	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AWM74_RS08795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AWM74_RS08800	COG1490	D-aminoacyl-tRNA deacylase activity
AWM74_RS08810	COG0124	histidyl-tRNA synthetase
AWM74_RS08815	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AWM74_RS08830	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AWM74_RS08840	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AWM74_RS08845	COG0167	dihydroorotate dehydrogenase activity
AWM74_RS08850	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AWM74_RS08855	COG0346	lactoylglutathione lyase activity
AWM74_RS08860	COG0735	belongs to the Fur family
AWM74_RS08870	COG1610	YqeY-like protein
AWM74_RS08875	COG1028	Short-chain dehydrogenase reductase Sdr
AWM74_RS08890	COG1702	phosphate starvation-inducible protein PhoH
AWM74_RS08895	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AWM74_RS08905	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AWM74_RS08910	COG1381	Involved in DNA repair and RecF pathway recombination
AWM74_RS08915	COG0752	glycyl-tRNA synthetase alpha subunit
AWM74_RS08920	COG0751	glycine-tRNA ligase activity
AWM74_RS08930	COG1234	tRNA 3'-trailer cleavage
AWM74_RS08935	COG4221	oxidoreductase activity
AWM74_RS08940	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AWM74_RS08940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AWM74_RS08945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWM74_RS08950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AWM74_RS08960	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AWM74_RS08970	COG4120	Belongs to the binding-protein-dependent transport system permease family
AWM74_RS08975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AWM74_RS08975	COG1116	anion transmembrane transporter activity
AWM74_RS08985	COG4166	transmembrane transport
AWM74_RS08990	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AWM74_RS08995	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AWM74_RS09005	COG1349	DNA-binding transcription factor activity
AWM74_RS09010	COG1105	Belongs to the carbohydrate kinase PfkB family
AWM74_RS09015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWM74_RS09015	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWM74_RS09015	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWM74_RS09020	COG1132	(ABC) transporter
AWM74_RS09025	COG1132	(ABC) transporter
AWM74_RS09035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWM74_RS09040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWM74_RS09045	COG2079	MmgE PrpD family protein
AWM74_RS09055	COG0456	acetyltransferase
AWM74_RS09060	COG0765	amino acid transport
AWM74_RS09065	COG1126	abc transporter atp-binding protein
AWM74_RS09075	COG2207	Transcriptional regulator
AWM74_RS09085	COG1653	transport
AWM74_RS09090	COG1175	transmembrane transport
AWM74_RS09095	COG0395	ABC-type sugar transport system, permease component
AWM74_RS09100	COG0366	Alpha amylase catalytic
AWM74_RS09105	COG3842	ATPase activity
AWM74_RS09115	COG1609	Transcriptional regulator
AWM74_RS09120	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AWM74_RS09125	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
AWM74_RS09145	COG2211	Major facilitator Superfamily
AWM74_RS09160	COG2086	electron transfer activity
AWM74_RS09165	COG1960	acyl-CoA dehydrogenase activity
AWM74_RS09190	COG4974	Belongs to the 'phage' integrase family
AWM74_RS09200	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AWM74_RS09205	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AWM74_RS09210	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AWM74_RS09215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AWM74_RS09220	COG0569	domain protein
AWM74_RS09225	COG1227	inorganic diphosphatase activity
AWM74_RS09235	COG0183	Belongs to the thiolase family
AWM74_RS09240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWM74_RS09245	COG0187	DNA topoisomerase II activity
AWM74_RS09260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AWM74_RS09265	COG0758	DNA mediated transformation
AWM74_RS09270	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AWM74_RS09285	COG1447	Phosphotransferase system cellobiose-specific component IIA