locus-tag	class	description
APT62_RS00015	COG4608	Belongs to the ABC transporter superfamily
APT62_RS00020	COG0601	transmembrane transport
APT62_RS00025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT62_RS00035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APT62_RS00040	COG0371	Dehydrogenase
APT62_RS00045	COG0346	lactoylglutathione lyase activity
APT62_RS00050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APT62_RS00055	COG0629	single-stranded DNA binding
APT62_RS00060	COG0360	Binds together with S18 to 16S ribosomal RNA
APT62_RS00065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APT62_RS00070	COG0187	DNA topoisomerase II activity
APT62_RS00075	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APT62_RS00080	COG2501	S4 domain
APT62_RS00085	COG0592	DNA-directed DNA polymerase activity
APT62_RS00105	COG0706	membrane insertase activity
APT62_RS00110	COG1847	R3H domain protein
APT62_RS00115	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
APT62_RS00120	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
APT62_RS00125	COG2213	PTS system mannitol-specific
APT62_RS00130	COG3711	transcriptional antiterminator
APT62_RS00135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT62_RS00140	COG0668	transmembrane transport
APT62_RS00150	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APT62_RS00155	COG0445	tRNA wobble uridine modification
APT62_RS00165	COG0357	Ribosomal RNA small subunit methyltransferase G
APT62_RS00170	COG1192	Involved in chromosome partitioning
APT62_RS00175	COG1475	DNA binding
APT62_RS00180	COG4481	Protein conserved in bacteria
APT62_RS00185	COG0012	GTP binding
APT62_RS00205	COG0516	GMP reductase activity
APT62_RS00205	COG0517	IMP dehydrogenase activity
APT62_RS00210	COG0745	RESPONSE REGULATOR receiver
APT62_RS00225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APT62_RS00230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APT62_RS00315	COG1363	Peptidase, m42
APT62_RS00325	COG0589	response to stress
APT62_RS00330	COG0039	L-malate dehydrogenase activity
APT62_RS00340	COG2514	catechol 2,3-dioxygenase activity
APT62_RS00345	COG0626	cystathionine gamma-synthase activity
APT62_RS00360	COG1737	Transcriptional regulator
APT62_RS00365	COG1486	melibiose metabolic process
APT62_RS00385	COG1302	Protein conserved in bacteria
APT62_RS00395	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
APT62_RS00400	COG0789	Transcriptional regulator
APT62_RS00405	COG1695	Transcriptional regulator
APT62_RS00465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APT62_RS00470	COG4856	YbbR-like protein
APT62_RS00480	COG1187	pseudouridine synthase activity
APT62_RS00500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APT62_RS00505	COG1028	Short-chain dehydrogenase reductase Sdr
APT62_RS00510	COG0363	glucosamine-6-phosphate deaminase activity
APT62_RS00515	COG2213	PTS system mannitol-specific
APT62_RS00520	COG3711	transcriptional antiterminator
APT62_RS00525	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT62_RS00530	COG0246	Mannitol dehydrogenase
APT62_RS00535	COG0436	Aminotransferase
APT62_RS00540	COG1464	Belongs to the NlpA lipoprotein family
APT62_RS00550	COG1028	Short-chain dehydrogenase reductase Sdr
APT62_RS00560	COG1028	Short-chain dehydrogenase reductase Sdr
APT62_RS00565	COG2226	methyltransferase
APT62_RS00575	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
APT62_RS00580	COG1304	FMN binding
APT62_RS00585	COG2252	PERMEase
APT62_RS00590	COG0366	Alpha amylase catalytic
APT62_RS00595	COG0561	phosphatase activity
APT62_RS00605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APT62_RS00625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APT62_RS00635	COG1119	ATPase activity
APT62_RS00640	COG0028	Belongs to the TPP enzyme family
APT62_RS00645	COG0440	acetolactate synthase activity
APT62_RS00655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APT62_RS00665	COG1263	PTS System
APT62_RS00665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APT62_RS00665	COG2190	(PTS) system
APT62_RS00670	COG2723	6-phospho-beta-galactosidase activity
APT62_RS00675	COG2272	Belongs to the type-B carboxylesterase lipase family
APT62_RS00680	COG4224	UPF0291 protein
APT62_RS00685	COG0400	carboxylic ester hydrolase activity
APT62_RS00690	COG0346	lactoylglutathione lyase activity
APT62_RS00695	COG2211	Major facilitator Superfamily
APT62_RS00700	COG1214	PFAM Peptidase M22, glycoprotease
APT62_RS00705	COG0456	acetyltransferase
APT62_RS00710	COG0456	acetyltransferase
APT62_RS00715	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APT62_RS00745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APT62_RS00755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APT62_RS00755	COG1263	PTS System
APT62_RS00760	COG1486	melibiose metabolic process
APT62_RS00765	COG1737	Transcriptional regulator
APT62_RS00780	COG2190	(PTS) system
APT62_RS00780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APT62_RS00780	COG1263	PTS System
APT62_RS00790	COG2182	Extracellular solute-binding protein
APT62_RS00795	COG1175	transmembrane transport
APT62_RS00800	COG3833	ABC-type maltose transport systems, permease component
APT62_RS00810	COG3842	ATPase activity
APT62_RS00815	COG0673	inositol 2-dehydrogenase activity
APT62_RS00830	COG0673	inositol 2-dehydrogenase activity
APT62_RS00835	COG1609	Transcriptional regulator
APT62_RS00840	COG1640	4-alpha-glucanotransferase
APT62_RS00845	COG0058	SHG alpha-glucan phosphorylase activity
APT62_RS00855	COG1940	carbohydrate kinase activity
APT62_RS00900	COG2851	Citrate transporter
APT62_RS00905	COG0473	3-isopropylmalate dehydrogenase activity
APT62_RS00910	COG4463	regulation of RNA biosynthetic process
APT62_RS00915	COG0542	response to heat
APT62_RS00935	COG2188	Transcriptional regulator
APT62_RS00940	COG0366	Alpha amylase catalytic
APT62_RS00945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APT62_RS00945	COG1263	PTS System
APT62_RS00950	COG0590	tRNA wobble adenosine to inosine editing
APT62_RS00960	COG1269	ATP hydrolysis coupled proton transport
APT62_RS00965	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APT62_RS00975	COG1527	subunit (C
APT62_RS00980	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
APT62_RS00985	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
APT62_RS00990	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
APT62_RS00995	COG1394	ATPase activity, coupled to movement of substances
APT62_RS01010	COG0513	Belongs to the DEAD box helicase family
APT62_RS01015	COG0494	nUDIX hydrolase
APT62_RS01030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APT62_RS01035	COG0183	Belongs to the thiolase family
APT62_RS01050	COG0488	(ABC) transporter
APT62_RS01070	COG0459	protein refolding
APT62_RS01080	COG0165	Argininosuccinate lyase
APT62_RS01085	COG0765	amino acid transport
APT62_RS01095	COG0431	NADPH-dependent FMN reductase
APT62_RS01100	COG0765	amino acid transport
APT62_RS01110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APT62_RS01115	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
APT62_RS01150	COG0277	FAD linked oxidase domain protein
APT62_RS01155	COG1739	Uncharacterized protein family UPF0029
APT62_RS01160	COG1307	EDD domain protein, DegV family
APT62_RS01165	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
APT62_RS01180	COG0653	protein targeting
APT62_RS01185	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APT62_RS01190	COG0745	RESPONSE REGULATOR receiver
APT62_RS01195	COG5002	protein histidine kinase activity
APT62_RS01200	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APT62_RS01205	COG0573	inorganic phosphate transmembrane transporter activity
APT62_RS01210	COG0581	inorganic phosphate transmembrane transporter activity
APT62_RS01215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APT62_RS01220	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APT62_RS01230	COG0419	ATPase involved in DNA repair
APT62_RS01245	COG1983	PspC domain protein
APT62_RS01260	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APT62_RS01265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APT62_RS01270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APT62_RS01275	COG0492	ferredoxin-NADP+ reductase activity
APT62_RS01280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APT62_RS01285	COG1660	Displays ATPase and GTPase activities
APT62_RS01295	COG1481	regulation of sporulation
APT62_RS01305	COG0629	single-stranded DNA binding
APT62_RS01310	COG0745	RESPONSE REGULATOR receiver
APT62_RS01315	COG3850	Histidine kinase
APT62_RS01315	COG5002	protein histidine kinase activity
APT62_RS01325	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
APT62_RS01335	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
APT62_RS01355	COG0737	Belongs to the 5'-nucleotidase family
APT62_RS01400	COG1705	Flagellar rod assembly protein muramidase FlgJ
APT62_RS01410	COG0210	DNA helicase
APT62_RS01415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APT62_RS01420	COG4851	CamS sex pheromone cAM373 precursor
APT62_RS01425	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APT62_RS01430	COG0154	amidase activity
APT62_RS01435	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APT62_RS01440	COG1940	carbohydrate kinase activity
APT62_RS01445	COG1609	Transcriptional regulator
APT62_RS01450	COG4209	transmembrane transport
APT62_RS01455	COG0395	ABC-type sugar transport system, permease component
APT62_RS01470	COG3842	ATPase activity
APT62_RS01480	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APT62_RS01485	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
APT62_RS01510	COG1304	FMN binding
APT62_RS01515	COG1346	cytolysis
APT62_RS01520	COG1380	Effector of murein hydrolase LrgA
APT62_RS01525	COG0583	DNA-binding transcription factor activity
APT62_RS01530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APT62_RS01535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT62_RS01545	COG2321	neutral zinc metallopeptidase
APT62_RS01560	COG1959	2 iron, 2 sulfur cluster binding
APT62_RS01565	COG2873	o-acetylhomoserine
APT62_RS01575	COG4895	conserved protein (DUF2196)
APT62_RS01660	COG0406	alpha-ribazole phosphatase activity
APT62_RS01670	COG2207	Transcriptional regulator
APT62_RS01690	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APT62_RS01690	COG0512	Glutamine amidotransferase of anthranilate synthase
APT62_RS01695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APT62_RS01700	COG0134	indole-3-glycerol-phosphate synthase activity
APT62_RS01710	COG0133	tryptophan synthase activity
APT62_RS01715	COG0159	tryptophan synthase activity
APT62_RS01740	COG1447	Phosphotransferase system cellobiose-specific component IIA
APT62_RS01745	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APT62_RS01750	COG4720	Psort location CytoplasmicMembrane, score
APT62_RS01755	COG2188	Transcriptional regulator
APT62_RS01765	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APT62_RS01770	COG2723	6-phospho-beta-galactosidase activity
APT62_RS01785	COG0564	pseudouridine synthase activity
APT62_RS01790	COG0583	DNA-binding transcription factor activity
APT62_RS01795	COG0110	maltose O-acetyltransferase activity
APT62_RS01800	COG1028	Short-chain dehydrogenase reductase Sdr
APT62_RS01815	COG0640	Transcriptional regulator
APT62_RS01820	COG1902	pentaerythritol trinitrate reductase activity
APT62_RS01825	COG0753	catalase activity
APT62_RS01845	COG3775	system Galactitol-specific IIC component
APT62_RS01850	COG1349	DNA-binding transcription factor activity
APT62_RS01855	COG1105	Belongs to the carbohydrate kinase PfkB family
APT62_RS01860	COG0698	ribose 5-phosphate isomerase
APT62_RS01870	COG3684	Belongs to the aldolase LacD family
APT62_RS01875	COG1447	Phosphotransferase system cellobiose-specific component IIA
APT62_RS01890	COG4807	Protein conserved in bacteria
APT62_RS01895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APT62_RS01920	COG0833	amino acid
APT62_RS01925	COG2040	homocysteine
APT62_RS01935	COG3527	Alpha-acetolactate decarboxylase
APT62_RS01955	COG0588	phosphoglycerate mutase activity
APT62_RS01960	COG0475	glutathione-regulated potassium exporter activity
APT62_RS01965	COG1028	Short-chain dehydrogenase reductase Sdr
APT62_RS01975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT62_RS02000	COG0628	permease
APT62_RS02005	COG0446	pyridine nucleotide-disulphide oxidoreductase
APT62_RS02010	COG1073	alpha beta
APT62_RS02015	COG1472	Belongs to the glycosyl hydrolase 3 family
APT62_RS02035	COG0745	RESPONSE REGULATOR receiver
APT62_RS02040	COG5002	protein histidine kinase activity
APT62_RS02050	COG4853	Protein conserved in bacteria
APT62_RS02060	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
APT62_RS02065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APT62_RS02070	COG0569	domain protein
APT62_RS02075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APT62_RS02080	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APT62_RS02085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APT62_RS02090	COG1966	Carbon starvation protein
APT62_RS02105	COG1522	sequence-specific DNA binding
APT62_RS02110	COG0436	Aminotransferase
APT62_RS02115	COG1335	isochorismatase
APT62_RS02135	COG2738	Putative neutral zinc metallopeptidase
APT62_RS02160	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
APT62_RS02165	COG2249	NAD(P)H dehydrogenase (quinone) activity
APT62_RS02175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APT62_RS02185	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APT62_RS02185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APT62_RS02190	COG0084	hydrolase, TatD family'
APT62_RS02200	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APT62_RS02205	COG4466	Protein conserved in bacteria
APT62_RS02210	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APT62_RS02215	COG0803	Belongs to the bacterial solute-binding protein 9 family
APT62_RS02215	COG3443	Belongs to the bacterial solute-binding protein 9 family
APT62_RS02220	COG1121	(ABC) transporter
APT62_RS02225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APT62_RS02230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APT62_RS02240	COG0297	glycogen (starch) synthase activity
APT62_RS02250	COG0297	glycogen (starch) synthase activity
APT62_RS02250	COG0438	transferase activity, transferring glycosyl groups
APT62_RS02265	COG1215	transferase activity, transferring glycosyl groups
APT62_RS02285	COG0463	Glycosyl transferase, family 2
APT62_RS02300	COG2309	aminopeptidase activity
APT62_RS02305	COG0716	FMN binding
APT62_RS02315	COG0024	Methionine aminopeptidase
APT62_RS02320	COG1316	TRANSCRIPTIONal
APT62_RS02325	COG1316	TRANSCRIPTIONal
APT62_RS02330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APT62_RS02355	COG1307	EDD domain protein, DegV family
APT62_RS02365	COG1051	belongs to the nudix hydrolase family
APT62_RS02370	COG4464	protein tyrosine phosphatase activity
APT62_RS02385	COG0489	protein tyrosine kinase activity
APT62_RS02395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT62_RS02400	COG0252	asparaginase activity
APT62_RS02405	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APT62_RS02410	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APT62_RS02415	COG1876	peptidase activity
APT62_RS02430	COG4120	Belongs to the binding-protein-dependent transport system permease family
APT62_RS02435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APT62_RS02440	COG1054	Belongs to the UPF0176 family
APT62_RS02455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
APT62_RS02475	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APT62_RS02520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT62_RS02525	COG0765	amino acid transport
APT62_RS02530	COG0765	amino acid transport
APT62_RS02540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APT62_RS02550	COG1312	Catalyzes the dehydration of D-mannonate
APT62_RS02555	COG1028	Short-chain dehydrogenase reductase Sdr
APT62_RS02565	COG0800	Aldolase
APT62_RS02575	COG1904	glucuronate isomerase
APT62_RS02580	COG3425	synthase
APT62_RS02610	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APT62_RS02615	COG0242	peptide deformylase activity
APT62_RS02625	COG0022	dehydrogenase e1 component
APT62_RS02640	COG0534	Mate efflux family protein
APT62_RS02650	COG0673	inositol 2-dehydrogenase activity
APT62_RS02675	COG1917	Cupin 2, conserved barrel domain protein
APT62_RS02675	COG2207	Transcriptional regulator
APT62_RS02680	COG1464	Belongs to the NlpA lipoprotein family
APT62_RS02685	COG4476	Belongs to the UPF0223 family
APT62_RS02690	COG0483	inositol monophosphate 1-phosphatase activity
APT62_RS02695	COG1217	gtp-binding protein TYPA
APT62_RS02700	COG0772	Belongs to the SEDS family
APT62_RS02710	COG1263	PTS System
APT62_RS02710	COG2190	(PTS) system
APT62_RS02710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APT62_RS02715	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
APT62_RS02720	COG4471	UPF0298 protein
APT62_RS02740	COG0783	Belongs to the Dps family
APT62_RS02745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APT62_RS02765	COG0742	ribosomal rna small subunit methyltransferase
APT62_RS02770	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APT62_RS02775	COG1555	photosystem II stabilization
APT62_RS02775	COG1596	polysaccharide export
APT62_RS02785	COG1466	dna polymerase III delta subunit
APT62_RS02795	COG0556	nucleotide-excision repair
APT62_RS02800	COG0671	phosphoesterase, PA-phosphatase related
APT62_RS02805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APT62_RS02810	COG1185	polyribonucleotide nucleotidyltransferase activity
APT62_RS02815	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APT62_RS02830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APT62_RS02840	COG0194	GDP metabolic process
APT62_RS02845	COG1758	RNA polymerase activity
APT62_RS02850	COG0402	S-adenosylhomocysteine deaminase activity
APT62_RS02855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APT62_RS02860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APT62_RS02865	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APT62_RS02865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APT62_RS02870	COG0631	protein serine/threonine phosphatase activity
APT62_RS02875	COG2815	serine threonine protein kinase
APT62_RS02875	COG0515	serine threonine protein kinase
APT62_RS02880	COG1162	GTPase activity
APT62_RS02885	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APT62_RS02890	COG1564	THIamine pyrophosphokinase
APT62_RS02895	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APT62_RS02900	COG1302	Protein conserved in bacteria
APT62_RS02905	COG1461	Dihydroxyacetone kinase
APT62_RS02920	COG1562	ergosterol biosynthetic process
APT62_RS02935	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APT62_RS02945	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APT62_RS02950	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
APT62_RS02955	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APT62_RS02960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APT62_RS02965	COG2244	polysaccharide biosynthetic process
APT62_RS02970	COG1216	Glycosyl transferase, family 2
APT62_RS02975	COG1442	glycosyl transferase family 8
APT62_RS02975	COG1216	Glycosyl transferase, family 2
APT62_RS03025	COG0489	protein tyrosine kinase activity
APT62_RS03075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT62_RS03085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APT62_RS03090	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APT62_RS03100	COG2089	acid synthase
APT62_RS03105	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
APT62_RS03120	COG1083	cytidylyl-transferase
APT62_RS03155	COG2151	metal-sulfur cluster biosynthetic enzyme
APT62_RS03160	COG2151	metal-sulfur cluster biosynthetic enzyme
APT62_RS03165	COG1882	Formate acetyltransferase
APT62_RS03170	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APT62_RS03175	COG1454	alcohol dehydrogenase
APT62_RS03175	COG1012	belongs to the aldehyde dehydrogenase family
APT62_RS03190	COG0708	Exodeoxyribonuclease III
APT62_RS03215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT62_RS03220	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APT62_RS03225	COG0416	fatty acid biosynthetic process
APT62_RS03230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APT62_RS03235	COG0571	ribonuclease III activity
APT62_RS03240	COG1196	nuclear chromosome segregation
APT62_RS03245	COG0561	phosphatase activity
APT62_RS03250	COG0552	protein localization to endoplasmic reticulum
APT62_RS03255	COG4894	glucomannan catabolic process
APT62_RS03260	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APT62_RS03265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APT62_RS03270	COG1940	carbohydrate kinase activity
APT62_RS03275	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
APT62_RS03280	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
APT62_RS03285	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
APT62_RS03290	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APT62_RS03300	COG1837	Belongs to the UPF0109 family
APT62_RS03320	COG0469	pyruvate kinase activity
APT62_RS03330	COG0335	large ribosomal subunit rRNA binding
APT62_RS03335	COG0038	chloride channel
APT62_RS03355	COG1857	crispr-associated protein
APT62_RS03370	COG1518	maintenance of DNA repeat elements
APT62_RS03395	COG0673	inositol 2-dehydrogenase activity
APT62_RS03400	COG0667	Aldo Keto reductase
APT62_RS03405	COG0789	Transcriptional regulator
APT62_RS03410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APT62_RS03415	COG2723	6-phospho-beta-galactosidase activity
APT62_RS03425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT62_RS03425	COG3711	transcriptional antiterminator
APT62_RS03435	COG1447	Phosphotransferase system cellobiose-specific component IIA
APT62_RS03440	COG2723	6-phospho-beta-galactosidase activity
APT62_RS03445	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
APT62_RS03450	COG1070	Carbohydrate kinase
APT62_RS03480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APT62_RS03485	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APT62_RS03490	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APT62_RS03495	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APT62_RS03500	COG0138	bifunctional purine biosynthesis protein purh
APT62_RS03505	COG0151	Belongs to the GarS family
APT62_RS03520	COG1132	(ABC) transporter
APT62_RS03535	COG0446	pyridine nucleotide-disulphide oxidoreductase
APT62_RS03540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APT62_RS03545	COG1937	Protein conserved in bacteria
APT62_RS03550	COG1733	regulation of RNA biosynthetic process
APT62_RS03560	COG0789	Transcriptional regulator
APT62_RS03585	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APT62_RS03595	COG0542	response to heat
APT62_RS03605	COG4864	UPF0365 protein
APT62_RS03620	COG0343	queuine tRNA-ribosyltransferase activity
APT62_RS03625	COG1862	Preprotein translocase
APT62_RS03645	COG4109	DRTGG domain
APT62_RS03650	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
APT62_RS03655	COG1744	ABC transporter substrate-binding protein PnrA-like
APT62_RS03660	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APT62_RS03665	COG0513	Belongs to the DEAD box helicase family
APT62_RS03675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APT62_RS03685	COG0768	penicillin binding
APT62_RS03690	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APT62_RS03695	COG0457	Tetratricopeptide repeat
APT62_RS03695	COG0705	Rhomboid family
APT62_RS03700	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APT62_RS03705	COG1940	carbohydrate kinase activity
APT62_RS03710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APT62_RS03715	COG0525	valine-tRNA ligase activity
APT62_RS03725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APT62_RS03730	COG2759	Belongs to the formate--tetrahydrofolate ligase family
APT62_RS03735	COG2003	Belongs to the UPF0758 family
APT62_RS03740	COG1278	Cold shock
APT62_RS03750	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
APT62_RS03755	COG1388	LysM domain
APT62_RS03755	COG1705	Flagellar rod assembly protein muramidase FlgJ
APT62_RS03760	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
APT62_RS03770	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APT62_RS03775	COG0495	leucyl-tRNA aminoacylation
APT62_RS03785	COG2244	polysaccharide biosynthetic process
APT62_RS03790	COG1187	pseudouridine synthase activity
APT62_RS03800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APT62_RS03810	COG1733	regulation of RNA biosynthetic process
APT62_RS03815	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APT62_RS03820	COG0072	phenylalanine-tRNA ligase activity
APT62_RS03825	COG1070	Carbohydrate kinase
APT62_RS03830	COG0280	phosphate acetyltransferase
APT62_RS03835	COG0802	atpase or kinase
APT62_RS03850	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APT62_RS03855	COG1122	ATPase activity
APT62_RS03860	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
APT62_RS03870	COG3257	ureidoglycine aminohydrolase activity
APT62_RS03875	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APT62_RS03880	COG2508	Transcriptional regulator
APT62_RS03885	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
APT62_RS03890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APT62_RS03895	COG1953	Uracil, thiamine, allantoin
APT62_RS03900	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APT62_RS03905	COG1301	dicarboxylic acid transport
APT62_RS03910	COG1301	dicarboxylic acid transport
APT62_RS03925	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APT62_RS03935	COG0549	Belongs to the carbamate kinase family
APT62_RS03940	COG1304	FMN binding
APT62_RS03955	COG0083	homoserine kinase activity
APT62_RS03980	COG1175	transmembrane transport
APT62_RS03990	COG3842	ATPase activity
APT62_RS03995	COG0584	glycerophosphoryl diester phosphodiesterase
APT62_RS04000	COG0673	inositol 2-dehydrogenase activity
APT62_RS04005	COG0673	inositol 2-dehydrogenase activity
APT62_RS04010	COG1737	Transcriptional regulator
APT62_RS04025	COG0561	phosphatase activity
APT62_RS04035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APT62_RS04040	COG0765	amino acid transport
APT62_RS04045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APT62_RS04055	COG1671	Belongs to the UPF0178 family
APT62_RS04060	COG2176	DNA-directed DNA polymerase activity
APT62_RS04070	COG1720	tRNA m6t6A37 methyltransferase activity
APT62_RS04075	COG0179	Fumarylacetoacetate (FAA) hydrolase
APT62_RS04110	COG0765	amino acid transport
APT62_RS04125	COG1193	negative regulation of DNA recombination
APT62_RS04130	COG3118	belongs to the thioredoxin family
APT62_RS04145	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APT62_RS04150	COG0622	Phosphoesterase
APT62_RS04155	COG0668	transmembrane transport
APT62_RS04175	COG2843	Capsule synthesis protein
APT62_RS04180	COG3830	Belongs to the UPF0237 family
APT62_RS04185	COG2848	UPF0210 protein
APT62_RS04190	COG0656	L-ascorbic acid biosynthetic process
APT62_RS04195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APT62_RS04205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APT62_RS04210	COG1597	lipid kinase activity
APT62_RS04215	COG0217	transcriptional regulatory protein
APT62_RS04220	COG1394	ATPase activity, coupled to movement of substances
APT62_RS04250	COG1269	ATP hydrolysis coupled proton transport
APT62_RS04265	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APT62_RS04270	COG1459	type II secretion system
APT62_RS04275	COG4537	Required for transformation and DNA binding
APT62_RS04300	COG0006	proline dipeptidase activity
APT62_RS04305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APT62_RS04315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APT62_RS04320	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APT62_RS04325	COG1570	exodeoxyribonuclease VII activity
APT62_RS04330	COG1722	exodeoxyribonuclease VII activity
APT62_RS04335	COG0142	geranyltranstransferase activity
APT62_RS04340	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
APT62_RS04345	COG0497	DNA recombination
APT62_RS04350	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APT62_RS04355	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APT62_RS04370	COG1295	ribonuclease BN
APT62_RS04375	COG0772	Belongs to the SEDS family
APT62_RS04380	COG0509	glycine decarboxylation via glycine cleavage system
APT62_RS04390	COG0577	efflux transmembrane transporter activity
APT62_RS04390	COG1136	(ABC) transporter
APT62_RS04400	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
APT62_RS04410	COG0018	arginyl-trna synthetase
APT62_RS04430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APT62_RS04450	COG2183	response to ionizing radiation
APT62_RS04455	COG0683	leucine binding
APT62_RS04460	COG0517	IMP dehydrogenase activity
APT62_RS04480	COG0346	lactoylglutathione lyase activity
APT62_RS04495	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APT62_RS04500	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APT62_RS04505	COG0297	glycogen (starch) synthase activity
APT62_RS04510	COG0527	aspartate kinase activity
APT62_RS04515	COG1968	undecaprenyl-diphosphatase activity
APT62_RS04520	COG2190	(PTS) system
APT62_RS04520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APT62_RS04520	COG1263	PTS System
APT62_RS04525	COG1744	ABC transporter substrate-binding protein PnrA-like
APT62_RS04530	COG3845	ABC transporter
APT62_RS04535	COG4603	Belongs to the binding-protein-dependent transport system permease family
APT62_RS04540	COG1079	Belongs to the binding-protein-dependent transport system permease family
APT62_RS04545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APT62_RS04550	COG2706	6-phosphogluconolactonase activity
APT62_RS04555	COG0628	permease
APT62_RS04560	COG1132	(ABC) transporter
APT62_RS04570	COG2135	peptidase activity
APT62_RS04575	COG3442	glutamine amidotransferase
APT62_RS04580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APT62_RS04585	COG1435	thymidine kinase activity
APT62_RS04590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APT62_RS04595	COG2890	protein-(glutamine-N5) methyltransferase activity
APT62_RS04600	COG0009	L-threonylcarbamoyladenylate synthase
APT62_RS04610	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APT62_RS04615	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APT62_RS04620	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APT62_RS04625	COG0196	riboflavin kinase activity
APT62_RS04630	COG1473	amidohydrolase
APT62_RS04635	COG1420	regulation of RNA biosynthetic process
APT62_RS04640	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APT62_RS04645	COG0443	Heat shock 70 kDa protein
APT62_RS04650	COG0484	heat shock protein binding
APT62_RS04665	COG1028	Short-chain dehydrogenase reductase Sdr
APT62_RS04670	COG1063	alcohol dehydrogenase
APT62_RS04680	COG0717	Belongs to the dCTP deaminase family
APT62_RS04685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APT62_RS04695	COG0488	(ABC) transporter
APT62_RS04720	COG0793	Belongs to the peptidase S41A family
APT62_RS04720	COG3409	Peptidoglycan-binding domain 1 protein
APT62_RS04735	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APT62_RS04740	COG0758	DNA mediated transformation
APT62_RS04745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APT62_RS04760	COG0187	DNA topoisomerase II activity
APT62_RS04765	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APT62_RS04770	COG0183	Belongs to the thiolase family
APT62_RS04780	COG1227	inorganic diphosphatase activity
APT62_RS04785	COG0569	domain protein
APT62_RS04790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APT62_RS04795	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APT62_RS04800	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APT62_RS04805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APT62_RS04815	COG4974	Belongs to the 'phage' integrase family
APT62_RS04825	COG1301	dicarboxylic acid transport
APT62_RS04845	COG2211	Major facilitator Superfamily
APT62_RS04865	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
APT62_RS04870	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
APT62_RS04875	COG1609	Transcriptional regulator
APT62_RS04880	COG0366	Alpha amylase catalytic
APT62_RS04885	COG3842	ATPase activity
APT62_RS04890	COG0366	Alpha amylase catalytic
APT62_RS04895	COG0395	ABC-type sugar transport system, permease component
APT62_RS04900	COG1175	transmembrane transport
APT62_RS04905	COG1653	transport
APT62_RS04915	COG2207	Transcriptional regulator
APT62_RS04925	COG1126	abc transporter atp-binding protein
APT62_RS04930	COG0765	amino acid transport
APT62_RS04935	COG0456	acetyltransferase
APT62_RS04945	COG2079	MmgE PrpD family protein
APT62_RS04950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT62_RS04955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT62_RS04965	COG1132	(ABC) transporter
APT62_RS04970	COG1132	(ABC) transporter
APT62_RS04975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APT62_RS04975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APT62_RS04975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT62_RS04980	COG1105	Belongs to the carbohydrate kinase PfkB family
APT62_RS04985	COG1349	DNA-binding transcription factor activity
APT62_RS04995	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APT62_RS05000	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APT62_RS05005	COG4166	transmembrane transport
APT62_RS05015	COG1116	anion transmembrane transporter activity
APT62_RS05015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT62_RS05020	COG4120	Belongs to the binding-protein-dependent transport system permease family
APT62_RS05030	COG1293	RNA-binding protein homologous to eukaryotic snRNP
APT62_RS05040	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APT62_RS05045	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APT62_RS05050	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APT62_RS05050	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
APT62_RS05055	COG4221	oxidoreductase activity
APT62_RS05060	COG1234	tRNA 3'-trailer cleavage
APT62_RS05070	COG0751	glycine-tRNA ligase activity
APT62_RS05075	COG0752	glycyl-tRNA synthetase alpha subunit
APT62_RS05080	COG1381	Involved in DNA repair and RecF pathway recombination
APT62_RS05085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APT62_RS05095	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APT62_RS05100	COG1702	phosphate starvation-inducible protein PhoH
APT62_RS05115	COG1028	Short-chain dehydrogenase reductase Sdr
APT62_RS05120	COG1610	YqeY-like protein
APT62_RS05130	COG0735	belongs to the Fur family
APT62_RS05135	COG0346	lactoylglutathione lyase activity
APT62_RS05140	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
APT62_RS05145	COG0167	dihydroorotate dehydrogenase activity
APT62_RS05150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APT62_RS05160	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APT62_RS05175	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APT62_RS05180	COG0124	histidyl-tRNA synthetase
APT62_RS05190	COG1490	D-aminoacyl-tRNA deacylase activity
APT62_RS05195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APT62_RS05200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APT62_RS05205	COG2264	protein methyltransferase activity
APT62_RS05215	COG3599	regulation of cell shape
APT62_RS05225	COG0116	Belongs to the methyltransferase superfamily
APT62_RS05245	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APT62_RS05250	COG0439	Biotin carboxylase
APT62_RS05255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APT62_RS05265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APT62_RS05275	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APT62_RS05315	COG0402	S-adenosylhomocysteine deaminase activity
APT62_RS05335	COG0588	phosphoglycerate mutase activity
APT62_RS05340	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
APT62_RS05345	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APT62_RS05350	COG0557	exoribonuclease II activity
APT62_RS05365	COG4608	Belongs to the ABC transporter superfamily
APT62_RS05370	COG0444	Belongs to the ABC transporter superfamily
APT62_RS05375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT62_RS05380	COG0601	transmembrane transport
APT62_RS05390	COG4166	transmembrane transport
APT62_RS05395	COG4166	transmembrane transport
APT62_RS05400	COG0148	phosphopyruvate hydratase activity
APT62_RS05405	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APT62_RS05410	COG0149	triose-phosphate isomerase activity
APT62_RS05425	COG2390	Transcriptional regulator
APT62_RS05435	COG0740	serine-type endopeptidase activity
APT62_RS05445	COG3759	membrane
APT62_RS05455	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APT62_RS05470	COG2740	Nucleic-acid-binding protein implicated in transcription termination
APT62_RS05475	COG0195	Participates in both transcription termination and antitermination
APT62_RS05480	COG0779	Required for maturation of 30S ribosomal subunits
APT62_RS05495	COG2176	DNA-directed DNA polymerase activity
APT62_RS05500	COG0750	zinc metalloprotease
APT62_RS05505	COG4589	Belongs to the CDS family
APT62_RS05510	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APT62_RS05530	COG0745	RESPONSE REGULATOR receiver
APT62_RS05535	COG5002	protein histidine kinase activity
APT62_RS05540	COG0233	cytoplasmic translational termination
APT62_RS05545	COG0528	UMP kinase activity
APT62_RS05550	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APT62_RS05555	COG0052	Belongs to the universal ribosomal protein uS2 family
APT62_RS05565	COG0628	permease
APT62_RS05570	COG0204	Acyl-transferase
APT62_RS05575	COG1132	(ABC) transporter
APT62_RS05580	COG1132	(ABC) transporter
APT62_RS05585	COG3763	UPF0154 protein
APT62_RS05590	COG0564	pseudouridine synthase activity
APT62_RS05595	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APT62_RS05600	COG3341	Caulimovirus viroplasmin
APT62_RS05600	COG0328	RNA-DNA hybrid ribonuclease activity
APT62_RS05610	COG1074	ATP-dependent DNA helicase activity
APT62_RS05615	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
APT62_RS05620	COG2195	Cleaves the N-terminal amino acid of tripeptides
APT62_RS05625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APT62_RS05630	COG2384	SAM-dependent methyltransferase
APT62_RS05650	COG0488	(ABC) transporter
APT62_RS05655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APT62_RS05660	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APT62_RS05665	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APT62_RS05670	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APT62_RS05675	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APT62_RS05680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APT62_RS05695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APT62_RS05700	COG0358	DNA primase activity
APT62_RS05705	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APT62_RS05710	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APT62_RS05715	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APT62_RS05720	COG1957	nucleoside hydrolase
APT62_RS05725	COG0544	peptidyl-prolyl cis-trans isomerase activity
APT62_RS05730	COG3331	DNA recombination
APT62_RS05735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APT62_RS05740	COG2267	carboxylic ester hydrolase activity
APT62_RS05750	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APT62_RS05755	COG1780	Probably involved in ribonucleotide reductase function
APT62_RS05760	COG3682	Transcriptional regulator
APT62_RS05765	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APT62_RS05770	COG0561	phosphatase activity
APT62_RS05775	COG0248	Ppx GppA phosphatase
APT62_RS05780	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
APT62_RS05785	COG0488	(ABC) transporter
APT62_RS05790	COG1132	(ABC) transporter
APT62_RS05795	COG1132	(ABC) transporter
APT62_RS05800	COG0628	permease
APT62_RS05805	COG1072	(Pantothenic acid kinase))
APT62_RS05815	COG0390	transport system, permease component
APT62_RS05820	COG4619	ABC transporter
APT62_RS05840	COG1307	EDD domain protein, DegV family
APT62_RS05855	COG1272	protein, Hemolysin III
APT62_RS05860	COG4129	membrane
APT62_RS05865	COG5503	Protein of unknown function (DUF1447)
APT62_RS05870	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
APT62_RS05875	COG2197	response regulator
APT62_RS05890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APT62_RS05900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APT62_RS05905	COG1511	domain protein
APT62_RS05910	COG1959	2 iron, 2 sulfur cluster binding
APT62_RS05915	COG3906	Belongs to the UPF0473 family
APT62_RS05920	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APT62_RS05925	COG4472	Bacterial protein of unknown function (DUF965)
APT62_RS05930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APT62_RS05935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APT62_RS05940	COG0482	sulfurtransferase activity
APT62_RS05950	COG1104	cysteine desulfurase activity
APT62_RS05960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APT62_RS05975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APT62_RS05985	COG3732	PTS system glucitol sorbitol-specific
APT62_RS05990	COG3730	PTS system glucitol sorbitol-specific
APT62_RS06000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT62_RS06000	COG3711	transcriptional antiterminator
APT62_RS06025	COG1737	Transcriptional regulator
APT62_RS06030	COG1263	PTS System
APT62_RS06030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APT62_RS06035	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
APT62_RS06045	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APT62_RS06060	COG2868	ribosomal protein
APT62_RS06070	COG1126	abc transporter atp-binding protein
APT62_RS06075	COG0765	amino acid transport
APT62_RS06085	COG1792	Involved in formation and maintenance of cell shape
APT62_RS06220	COG0166	Belongs to the GPI family
APT62_RS06225	COG1098	S1 RNA binding domain
APT62_RS06230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APT62_RS06235	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
APT62_RS06240	COG0492	ferredoxin-NADP+ reductase activity
APT62_RS06250	COG0647	UMP catabolic process
APT62_RS06255	COG4470	Protein conserved in bacteria
APT62_RS06260	COG0737	Belongs to the 5'-nucleotidase family
APT62_RS06265	COG1846	Transcriptional regulator
APT62_RS06270	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APT62_RS06290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APT62_RS06290	COG1199	ATP-dependent helicase activity
APT62_RS06295	COG0617	tRNA 3'-terminal CCA addition
APT62_RS06300	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APT62_RS06315	COG1609	Transcriptional regulator
APT62_RS06320	COG1621	beta-fructofuranosidase activity
APT62_RS06335	COG1160	GTP binding
APT62_RS06340	COG0539	negative regulation of cytoplasmic translation
APT62_RS06345	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
APT62_RS06355	COG0514	ATP-dependent DNA helicase (RecQ)
APT62_RS06365	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
APT62_RS06370	COG1187	pseudouridine synthase activity
APT62_RS06375	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APT62_RS06380	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
APT62_RS06385	COG0456	acetyltransferase
APT62_RS06390	COG1668	transmembrane transport
APT62_RS06395	COG4152	abc transporter atp-binding protein
APT62_RS06405	COG2996	Protein conserved in bacteria
APT62_RS06410	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APT62_RS06420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APT62_RS06430	COG0205	6-phosphofructokinase activity
APT62_RS06435	COG0587	DNA-directed DNA polymerase activity
APT62_RS06440	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APT62_RS06445	COG2255	four-way junction helicase activity
APT62_RS06460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APT62_RS06465	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APT62_RS06470	COG1914	H( )-stimulated, divalent metal cation uptake system
APT62_RS06485	COG2723	6-phospho-beta-galactosidase activity
APT62_RS06490	COG1263	PTS System
APT62_RS06490	COG2190	(PTS) system
APT62_RS06490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APT62_RS06520	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APT62_RS06530	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APT62_RS06535	COG1674	ftsk spoiiie
APT62_RS06535	COG1280	lysine exporter protein (LysE YggA)
APT62_RS06545	COG1254	Belongs to the acylphosphatase family
APT62_RS06550	COG0706	membrane insertase activity
APT62_RS06555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APT62_RS06560	COG0028	Belongs to the TPP enzyme family
APT62_RS06565	COG0110	maltose O-acetyltransferase activity
APT62_RS06575	COG0745	RESPONSE REGULATOR receiver
APT62_RS06580	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
APT62_RS06590	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APT62_RS06595	COG0301	tRNA thio-modification
APT62_RS06600	COG1104	cysteine desulfurase activity
APT62_RS06605	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
APT62_RS06610	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APT62_RS06625	COG0494	nUDIX hydrolase
APT62_RS06635	COG3853	Toxic anion resistance protein (TelA)
APT62_RS06640	COG2261	transglycosylase associated protein
APT62_RS06650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APT62_RS06655	COG3599	regulation of cell shape
APT62_RS06660	COG2302	S4 RNA-binding domain
APT62_RS06675	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APT62_RS06685	COG0849	cell division
APT62_RS06690	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
APT62_RS06695	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APT62_RS06700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APT62_RS06705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APT62_RS06710	COG0768	penicillin binding
APT62_RS06725	COG2001	Belongs to the MraZ family
APT62_RS06740	COG1399	metal-binding, possibly nucleic acid-binding protein
APT62_RS06745	COG1323	Belongs to the UPF0348 family
APT62_RS06750	COG2226	methyltransferase
APT62_RS06755	COG0799	negative regulation of ribosome biogenesis
APT62_RS06760	COG1713	HD superfamily hydrolase involved in NAD metabolism
APT62_RS06765	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APT62_RS06770	COG1534	Rna-binding protein
APT62_RS06775	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
APT62_RS06780	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
APT62_RS06785	COG0083	homoserine kinase activity
APT62_RS06790	COG0460	homoserine dehydrogenase
APT62_RS06795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APT62_RS06800	COG4703	Protein of unknown function (DUF1797)
APT62_RS06805	COG0438	transferase activity, transferring glycosyl groups
APT62_RS06815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT62_RS06820	COG0542	response to heat
APT62_RS06830	COG0583	DNA-binding transcription factor activity
APT62_RS06835	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
APT62_RS06850	COG0625	glutathione transferase activity
APT62_RS06855	COG0105	UTP biosynthetic process
APT62_RS06860	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APT62_RS06870	COG2239	Acts as a magnesium transporter
APT62_RS06880	COG0564	pseudouridine synthase activity
APT62_RS06890	COG2357	RelA SpoT domain protein
APT62_RS06915	COG0180	Tryptophanyl-tRNA synthetase
APT62_RS06920	COG1393	Belongs to the ArsC family
APT62_RS06925	COG4862	establishment of competence for transformation
APT62_RS06930	COG0095	Lipoate-protein ligase
APT62_RS06940	COG1464	Belongs to the NlpA lipoprotein family
APT62_RS06945	COG1464	Belongs to the NlpA lipoprotein family
APT62_RS06950	COG2011	ABC-type metal ion transport system permease component
APT62_RS06955	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APT62_RS06960	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APT62_RS06970	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APT62_RS06980	COG1464	Belongs to the NlpA lipoprotein family
APT62_RS06985	COG2818	Glycosylase
APT62_RS06995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APT62_RS07000	COG1302	Protein conserved in bacteria
APT62_RS07015	COG1484	DNA-dependent DNA replication
APT62_RS07025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APT62_RS07035	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APT62_RS07040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APT62_RS07040	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APT62_RS07050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APT62_RS07055	COG0406	alpha-ribazole phosphatase activity
APT62_RS07065	COG0191	fructose-bisphosphate aldolase activity
APT62_RS07070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APT62_RS07070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APT62_RS07075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APT62_RS07080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APT62_RS07080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT62_RS07080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APT62_RS07085	COG3711	transcriptional antiterminator
APT62_RS07090	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APT62_RS07095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APT62_RS07100	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APT62_RS07105	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APT62_RS07110	COG0302	gtp cyclohydrolase
APT62_RS07120	COG0435	Glutathione S-transferase
APT62_RS07125	COG2270	Major facilitator Superfamily
APT62_RS07130	COG1573	uracil-dna glycosylase
APT62_RS07150	COG1785	Belongs to the alkaline phosphatase family
APT62_RS07165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APT62_RS07175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APT62_RS07185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APT62_RS07190	COG0510	thiamine kinase activity
APT62_RS07195	COG4473	ABC transporter
APT62_RS07200	COG1131	(ABC) transporter
APT62_RS07205	COG0537	adenosine 5'-monophosphoramidase activity
APT62_RS07215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APT62_RS07235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APT62_RS07240	COG0737	Belongs to the 5'-nucleotidase family
APT62_RS07250	COG3481	metal-dependent phosphohydrolase, HD sub domain
APT62_RS07255	COG4717	serine-type aminopeptidase activity
APT62_RS07260	COG0420	3'-5' exonuclease activity
APT62_RS07265	COG3679	Belongs to the UPF0342 family
APT62_RS07270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APT62_RS07280	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APT62_RS07290	COG3949	Membrane
APT62_RS07295	COG0686	Belongs to the AlaDH PNT family
APT62_RS07300	COG1126	abc transporter atp-binding protein
APT62_RS07305	COG0765	amino acid transport
APT62_RS07310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT62_RS07315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT62_RS07320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT62_RS07325	COG0765	amino acid transport
APT62_RS07330	COG0454	-acetyltransferase
APT62_RS07335	COG0431	NADPH-dependent FMN reductase
APT62_RS07340	COG1464	Belongs to the NlpA lipoprotein family
APT62_RS07345	COG2011	ABC-type metal ion transport system permease component
APT62_RS07370	COG2723	6-phospho-beta-galactosidase activity
APT62_RS07375	COG2190	(PTS) system
APT62_RS07375	COG1263	PTS System
APT62_RS07375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APT62_RS07390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT62_RS07400	COG0561	phosphatase activity
APT62_RS07405	COG0667	Aldo Keto reductase
APT62_RS07410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APT62_RS07425	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APT62_RS07430	COG2188	Transcriptional regulator
APT62_RS07435	COG2723	6-phospho-beta-galactosidase activity
APT62_RS07440	COG0406	alpha-ribazole phosphatase activity
APT62_RS07445	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APT62_RS07450	COG1464	Belongs to the NlpA lipoprotein family
APT62_RS07455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT62_RS07565	COG4989	oxidoreductase activity
APT62_RS07575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APT62_RS07580	COG4129	membrane
APT62_RS07585	COG1523	belongs to the glycosyl hydrolase 13 family
APT62_RS07595	COG3557	Belongs to the UPF0374 family
APT62_RS07600	COG1194	a g-specific adenine glycosylase
APT62_RS07605	COG2137	regulation of response to DNA damage stimulus
APT62_RS07630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APT62_RS07645	COG4166	transmembrane transport
APT62_RS07655	COG3493	citrate carrier protein
APT62_RS07660	COG3290	protein histidine kinase activity
APT62_RS07665	COG4565	transcriptional regulatory protein
APT62_RS07670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT62_RS07675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT62_RS07680	COG0765	amino acid transport
APT62_RS07685	COG1126	abc transporter atp-binding protein
APT62_RS07690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT62_RS07695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APT62_RS07700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT62_RS07710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APT62_RS07715	COG2423	ornithine cyclodeaminase activity
APT62_RS07720	COG2217	Heavy metal translocating P-type atpase
APT62_RS07735	COG4708	membrane
APT62_RS07740	COG0702	epimerase
APT62_RS07760	COG0656	L-ascorbic acid biosynthetic process
APT62_RS07780	COG0803	Belongs to the bacterial solute-binding protein 9 family
APT62_RS07780	COG3443	Belongs to the bacterial solute-binding protein 9 family
APT62_RS07785	COG0386	Belongs to the glutathione peroxidase family
APT62_RS07790	COG2188	Transcriptional regulator
APT62_RS07805	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
APT62_RS07810	COG0140	phosphoribosyl-ATP diphosphatase activity
APT62_RS07810	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APT62_RS07815	COG0107	imidazoleglycerol-phosphate synthase activity
APT62_RS07820	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APT62_RS07825	COG0131	Imidazoleglycerol-phosphate dehydratase
APT62_RS07830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APT62_RS07835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APT62_RS07840	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APT62_RS07845	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
APT62_RS07850	COG2211	Major facilitator Superfamily
APT62_RS07855	COG1725	Transcriptional regulator
APT62_RS07860	COG1131	(ABC) transporter
APT62_RS07875	COG4608	Belongs to the ABC transporter superfamily
APT62_RS07880	COG0444	Belongs to the ABC transporter superfamily
APT62_RS07895	COG0601	transmembrane transport
APT62_RS07900	COG1473	amidohydrolase
APT62_RS07905	COG1473	amidohydrolase
APT62_RS07925	COG3835	regulator
APT62_RS07930	COG1929	Belongs to the glycerate kinase type-1 family
APT62_RS07935	COG2610	gluconate transmembrane transporter activity
APT62_RS07945	COG0351	phosphomethylpyrimidine kinase
APT62_RS07950	COG0352	thiamine-phosphate diphosphorylase activity
APT62_RS07965	COG3339	Conserved Protein
APT62_RS07975	COG1733	regulation of RNA biosynthetic process
APT62_RS07985	COG2723	6-phospho-beta-galactosidase activity
APT62_RS08000	COG1309	transcriptional regulator
APT62_RS08015	COG1442	glycosyl transferase family 8
APT62_RS08030	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APT62_RS08030	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APT62_RS08055	COG1942	4-Oxalocrotonate Tautomerase
APT62_RS08060	COG0662	Cupin 2, conserved barrel domain protein
APT62_RS08075	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
APT62_RS08080	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APT62_RS08085	COG0583	DNA-binding transcription factor activity
APT62_RS08090	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APT62_RS08110	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APT62_RS08130	COG1122	ATPase activity
APT62_RS08135	COG1122	ATPase activity
APT62_RS08145	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
APT62_RS08145	COG2755	lipolytic protein G-D-S-L family
APT62_RS08150	COG0203	ribosomal protein L17
APT62_RS08155	COG0202	RNA polymerase activity
APT62_RS08160	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APT62_RS08165	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APT62_RS08175	COG0563	adenylate kinase activity
APT62_RS08190	COG1841	ribosomal large subunit assembly
APT62_RS08195	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APT62_RS08200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APT62_RS08205	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APT62_RS08210	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APT62_RS08215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APT62_RS08225	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APT62_RS08230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APT62_RS08235	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APT62_RS08240	COG0255	Belongs to the universal ribosomal protein uL29 family
APT62_RS08245	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APT62_RS08250	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APT62_RS08255	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APT62_RS08270	COG0089	rRNA binding
APT62_RS08275	COG0088	Forms part of the polypeptide exit tunnel
APT62_RS08280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APT62_RS08285	COG0051	transcription antitermination factor activity, RNA binding
APT62_RS08305	COG1122	ATPase activity
APT62_RS08315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APT62_RS08320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APT62_RS08325	COG0049	tRNA binding
APT62_RS08330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APT62_RS08335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APT62_RS08340	COG0640	Transcriptional regulator
APT62_RS08350	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
APT62_RS08355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APT62_RS08360	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
APT62_RS08365	COG0037	tRNA processing
APT62_RS08370	COG1098	S1 RNA binding domain
APT62_RS08380	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
APT62_RS08385	COG2244	polysaccharide biosynthetic process
APT62_RS08390	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APT62_RS08395	COG0193	aminoacyl-tRNA hydrolase activity
APT62_RS08400	COG0039	L-malate dehydrogenase activity
APT62_RS08410	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APT62_RS08420	COG0513	Belongs to the DEAD box helicase family
APT62_RS08425	COG1408	metallophosphoesterase
APT62_RS08430	COG0322	excinuclease ABC activity
APT62_RS08455	COG2732	(Barnase) inhibitor
APT62_RS08460	COG4290	ribonuclease
APT62_RS08465	COG0288	reversible hydration of carbon dioxide
APT62_RS08470	COG2326	polyphosphate kinase activity
APT62_RS08520	COG4122	O-methyltransferase activity
APT62_RS08525	COG1253	flavin adenine dinucleotide binding
APT62_RS08540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APT62_RS08545	COG4708	membrane
APT62_RS08550	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
APT62_RS08565	COG1174	glycine betaine transport
APT62_RS08585	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APT62_RS08590	COG1181	Belongs to the D-alanine--D-alanine ligase family
APT62_RS08605	COG3764	Sortase (surface protein transpeptidase)
APT62_RS08615	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APT62_RS08620	COG0456	acetyltransferase
APT62_RS08625	COG0251	oxidation-reduction process
APT62_RS08630	COG0254	rRNA binding
APT62_RS08635	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APT62_RS08640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APT62_RS08650	COG3976	FMN-binding domain protein
APT62_RS08650	COG0431	NADPH-dependent FMN reductase
APT62_RS08650	COG1053	succinate dehydrogenase
APT62_RS08665	COG2832	Protein of unknown function (DUF454)
APT62_RS08670	COG2814	Major facilitator Superfamily
APT62_RS08680	COG0284	orotidine-5'-phosphate decarboxylase activity
APT62_RS08690	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APT62_RS08695	COG1464	Belongs to the NlpA lipoprotein family
APT62_RS08705	COG1854	S-ribosylhomocysteine lyase activity
APT62_RS08710	COG0504	CTP synthase activity
APT62_RS08715	COG3343	RNA polymerase activity
APT62_RS08725	COG0095	Lipoate-protein ligase
APT62_RS08730	COG1078	dGTPase activity
APT62_RS08735	COG2814	Major facilitator Superfamily
APT62_RS08740	COG0436	Aminotransferase
APT62_RS08745	COG1132	(ABC) transporter
APT62_RS08755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT62_RS08760	COG0372	Belongs to the citrate synthase family
APT62_RS08770	COG2079	MmgE PrpD family protein
APT62_RS08775	COG1970	mechanosensitive ion channel activity
APT62_RS08785	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APT62_RS08790	COG2827	Endonuclease containing a URI domain
APT62_RS08795	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
APT62_RS08800	COG4467	Involved in initiation control of chromosome replication
APT62_RS08810	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
APT62_RS08810	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
APT62_RS08830	COG1122	ATPase activity
APT62_RS08845	COG1131	(ABC) transporter
APT62_RS08850	COG1396	sequence-specific DNA binding
APT62_RS08855	COG0470	DNA polymerase III
APT62_RS08865	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APT62_RS08870	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APT62_RS08875	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APT62_RS08880	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APT62_RS08885	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
APT62_RS08890	COG3842	ATPase activity
APT62_RS08895	COG0395	ABC-type sugar transport system, permease component
APT62_RS08905	COG1653	transport
APT62_RS08940	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APT62_RS08950	COG0446	pyridine nucleotide-disulphide oxidoreductase
APT62_RS08970	COG4175	Glycine betaine
APT62_RS08970	COG3448	diguanylate cyclase activity
APT62_RS08975	COG2813	Specifically methylates the guanine in position
APT62_RS08980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APT62_RS08985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APT62_RS08985	COG1321	iron dependent repressor
APT62_RS08990	COG1121	(ABC) transporter
APT62_RS09000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT62_RS09005	COG0765	amino acid transport
APT62_RS09015	COG1028	Short-chain dehydrogenase reductase Sdr
APT62_RS09020	COG0222	ribosome binding
APT62_RS09030	COG0081	regulation of translation
APT62_RS09040	COG0704	Plays a role in the regulation of phosphate uptake
APT62_RS09050	COG0250	Participates in transcription elongation, termination and antitermination
APT62_RS09060	COG2610	gluconate transmembrane transporter activity
APT62_RS09080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APT62_RS09085	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
APT62_RS09120	COG3173	Aminoglycoside phosphotransferase
APT62_RS09130	COG0546	phosphoglycolate phosphatase activity
APT62_RS09140	COG1464	Belongs to the NlpA lipoprotein family
APT62_RS09145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APT62_RS09150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APT62_RS09155	COG1125	glycine betaine transport
APT62_RS09155	COG0517	IMP dehydrogenase activity
APT62_RS09160	COG1174	glycine betaine transport
APT62_RS09170	COG2233	PERMEase
APT62_RS09175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APT62_RS09185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APT62_RS09190	COG1780	Probably involved in ribonucleotide reductase function
APT62_RS09200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APT62_RS09205	COG4956	integral membrane protein (PIN domain superfamily)
APT62_RS09210	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APT62_RS09215	COG0756	dUTP diphosphatase activity
APT62_RS09240	COG1496	oxidoreductase activity
APT62_RS09270	COG1136	(ABC) transporter
APT62_RS09285	COG2116	formate transmembrane transporter activity
APT62_RS09290	COG1482	cell wall glycoprotein biosynthetic process
APT62_RS09300	COG3716	PTS system mannose fructose sorbose family IID component
APT62_RS09305	COG3715	PTS system
APT62_RS09325	COG0789	Transcriptional regulator
APT62_RS09330	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
APT62_RS09335	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
APT62_RS09340	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
APT62_RS09345	COG2376	Dihydroxyacetone kinase
APT62_RS09350	COG1461	Dihydroxyacetone kinase
APT62_RS09355	COG2217	Heavy metal translocating P-type atpase
APT62_RS09360	COG2151	metal-sulfur cluster biosynthetic enzyme
APT62_RS09375	COG1328	CTP reductase activity
APT62_RS09380	COG0602	queuosine metabolic process
APT62_RS09385	COG1428	Deoxynucleoside kinase
APT62_RS09390	COG1418	mRNA catabolic process
APT62_RS09400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APT62_RS09405	COG1346	cytolysis
APT62_RS09420	COG0596	Alpha beta hydrolase
APT62_RS09435	COG1428	Deoxynucleoside kinase
APT62_RS09440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APT62_RS09440	COG1263	PTS System
APT62_RS09440	COG2190	(PTS) system
APT62_RS09445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APT62_RS09450	COG0693	protein deglycase activity
APT62_RS09460	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
APT62_RS09470	COG1122	ATPase activity
APT62_RS09485	COG2217	Heavy metal translocating P-type atpase
APT62_RS09500	COG0305	Participates in initiation and elongation during chromosome replication
APT62_RS09505	COG0359	binds to the 23S rRNA