locus-tag	class	description
C3E78_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C3E78_RS00010	COG0592	DNA-directed DNA polymerase activity
C3E78_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C3E78_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C3E78_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C3E78_RS00035	COG0187	DNA topoisomerase II activity
C3E78_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C3E78_RS00045	COG3266	domain, Protein
C3E78_RS00085	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C3E78_RS00105	COG0601	transmembrane transport
C3E78_RS00110	COG4166	transmembrane transport
C3E78_RS00125	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C3E78_RS00140	COG1024	Enoyl-CoA hydratase
C3E78_RS00145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C3E78_RS00150	COG0705	Rhomboid family
C3E78_RS00165	COG0515	serine threonine protein kinase
C3E78_RS00170	COG0768	penicillin binding
C3E78_RS00185	COG1716	ATPase activity
C3E78_RS00190	COG1716	ATPase activity
C3E78_RS00200	COG2814	Major facilitator Superfamily
C3E78_RS00220	COG0693	protein deglycase activity
C3E78_RS00230	COG1024	Enoyl-CoA hydratase
C3E78_RS00245	COG0584	glycerophosphoryl diester phosphodiesterase
C3E78_RS00255	COG0477	Major facilitator Superfamily
C3E78_RS00265	COG0697	spore germination
C3E78_RS00270	COG1309	transcriptional regulator
C3E78_RS00275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3E78_RS00295	COG4221	oxidoreductase activity
C3E78_RS00305	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C3E78_RS00310	COG0776	regulation of translation
C3E78_RS00320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C3E78_RS00355	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C3E78_RS00360	COG1597	lipid kinase activity
C3E78_RS00365	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C3E78_RS00370	COG0561	phosphatase activity
C3E78_RS00375	COG1733	regulation of RNA biosynthetic process
C3E78_RS00380	COG0667	Aldo Keto reductase
C3E78_RS00385	COG0432	Pfam Uncharacterised protein family UPF0047
C3E78_RS00405	COG3321	synthase
C3E78_RS00405	COG0604	alcohol dehydrogenase
C3E78_RS00405	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS00410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3E78_RS00470	COG0489	protein tyrosine kinase activity
C3E78_RS00490	COG2244	polysaccharide biosynthetic process
C3E78_RS00495	COG0438	transferase activity, transferring glycosyl groups
C3E78_RS00525	COG0477	Major facilitator Superfamily
C3E78_RS00550	COG1088	dTDP-glucose 4,6-dehydratase activity
C3E78_RS00565	COG0477	Major facilitator Superfamily
C3E78_RS00570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3E78_RS00585	COG0800	Aldolase
C3E78_RS00605	COG0444	Belongs to the ABC transporter superfamily
C3E78_RS00615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3E78_RS00620	COG0601	transmembrane transport
C3E78_RS00645	COG2827	Endonuclease containing a URI domain
C3E78_RS00650	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C3E78_RS00655	COG0604	alcohol dehydrogenase
C3E78_RS00655	COG3321	synthase
C3E78_RS00660	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C3E78_RS00680	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C3E78_RS00715	COG1045	serine acetyltransferase
C3E78_RS00725	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C3E78_RS00725	COG2755	lipolytic protein G-D-S-L family
C3E78_RS00745	COG1366	Belongs to the anti-sigma-factor antagonist family
C3E78_RS00750	COG4251	negative regulation of phosphorylation
C3E78_RS00755	COG0596	Alpha beta hydrolase
C3E78_RS00760	COG2208	phosphoserine phosphatase activity
C3E78_RS00760	COG2770	Histidine kinase
C3E78_RS00765	COG1793	dna ligase
C3E78_RS00800	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C3E78_RS00805	COG0110	maltose O-acetyltransferase activity
C3E78_RS00810	COG1012	belongs to the aldehyde dehydrogenase family
C3E78_RS00820	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C3E78_RS00825	COG0583	DNA-binding transcription factor activity
C3E78_RS00845	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS00860	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C3E78_RS00865	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C3E78_RS00870	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C3E78_RS00880	COG0037	tRNA processing
C3E78_RS00880	COG0590	tRNA wobble adenosine to inosine editing
C3E78_RS00885	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS00885	COG3321	synthase
C3E78_RS00885	COG0604	alcohol dehydrogenase
C3E78_RS00890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3E78_RS00900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3E78_RS00910	COG1072	(Pantothenic acid kinase))
C3E78_RS00925	COG1619	proteins homologs of microcin C7 resistance protein MccF
C3E78_RS00935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3E78_RS00970	COG4221	oxidoreductase activity
C3E78_RS00975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C3E78_RS00985	COG0022	dehydrogenase e1 component
C3E78_RS00990	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3E78_RS01010	COG0667	Aldo Keto reductase
C3E78_RS01055	COG3263	regulation of cellular component size
C3E78_RS01090	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C3E78_RS01145	COG0142	geranyltranstransferase activity
C3E78_RS01165	COG1024	Enoyl-CoA hydratase
C3E78_RS01175	COG0395	ABC-type sugar transport system, permease component
C3E78_RS01190	COG1024	Enoyl-CoA hydratase
C3E78_RS01195	COG0318	PFAM AMP-dependent synthetase and ligase
C3E78_RS01205	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS01215	COG1960	acyl-CoA dehydrogenase activity
C3E78_RS01220	COG1960	acyl-CoA dehydrogenase activity
C3E78_RS01225	COG0183	Belongs to the thiolase family
C3E78_RS01245	COG2076	Multidrug Resistance protein
C3E78_RS01270	COG1960	acyl-CoA dehydrogenase activity
C3E78_RS01290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C3E78_RS01310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C3E78_RS01325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3E78_RS01335	COG1408	metallophosphoesterase
C3E78_RS01345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3E78_RS01380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3E78_RS01395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3E78_RS01400	COG0494	nUDIX hydrolase
C3E78_RS01405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3E78_RS01420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3E78_RS01425	COG2197	response regulator
C3E78_RS01430	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3E78_RS01440	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3E78_RS01455	COG3275	phosphorelay sensor kinase activity
C3E78_RS01460	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C3E78_RS01465	COG1122	ATPase activity
C3E78_RS01470	COG1268	BioY protein
C3E78_RS01540	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C3E78_RS01540	COG2755	lipolytic protein G-D-S-L family
C3E78_RS01545	COG1205	dead DEAH box helicase
C3E78_RS01545	COG1111	helicase
C3E78_RS01550	COG1366	Belongs to the anti-sigma-factor antagonist family
C3E78_RS01555	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C3E78_RS01560	COG2890	protein-(glutamine-N5) methyltransferase activity
C3E78_RS01580	COG1754	DNA topoisomerase type I activity
C3E78_RS01580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C3E78_RS01585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C3E78_RS01590	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C3E78_RS01595	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C3E78_RS01605	COG0287	Prephenate dehydrogenase
C3E78_RS01605	COG1605	Chorismate mutase
C3E78_RS01625	COG1959	2 iron, 2 sulfur cluster binding
C3E78_RS01630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3E78_RS01660	COG2815	serine threonine protein kinase
C3E78_RS01660	COG0515	serine threonine protein kinase
C3E78_RS01665	COG0640	Transcriptional regulator
C3E78_RS01670	COG0798	PFAM Bile acid sodium symporter
C3E78_RS01675	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C3E78_RS01690	COG2223	nitrite transmembrane transporter activity
C3E78_RS01695	COG3764	Sortase (surface protein transpeptidase)
C3E78_RS01700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C3E78_RS01715	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3E78_RS01735	COG1597	lipid kinase activity
C3E78_RS01750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C3E78_RS01755	COG0151	Belongs to the GarS family
C3E78_RS01760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C3E78_RS01770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C3E78_RS01775	COG0318	PFAM AMP-dependent synthetase and ligase
C3E78_RS01780	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C3E78_RS01785	COG0047	phosphoribosylformylglycinamidine synthase activity
C3E78_RS01830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C3E78_RS01855	COG1902	pentaerythritol trinitrate reductase activity
C3E78_RS01860	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C3E78_RS01880	COG0318	PFAM AMP-dependent synthetase and ligase
C3E78_RS01895	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C3E78_RS01920	COG1846	Transcriptional regulator
C3E78_RS01925	COG1309	transcriptional regulator
C3E78_RS01945	COG0778	Nitroreductase
C3E78_RS01970	COG1125	glycine betaine transport
C3E78_RS01970	COG0517	IMP dehydrogenase activity
C3E78_RS01975	COG1174	glycine betaine transport
C3E78_RS01990	COG2409	Drug exporters of the RND superfamily
C3E78_RS02000	COG2197	response regulator
C3E78_RS02010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3E78_RS02015	COG0456	acetyltransferase
C3E78_RS02025	COG1366	Belongs to the anti-sigma-factor antagonist family
C3E78_RS02030	COG2124	cytochrome p450
C3E78_RS02045	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3E78_RS02065	COG1793	dna ligase
C3E78_RS02080	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C3E78_RS02100	COG1295	ribonuclease BN
C3E78_RS02115	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS02120	COG2890	protein-(glutamine-N5) methyltransferase activity
C3E78_RS02135	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C3E78_RS02135	COG2755	lipolytic protein G-D-S-L family
C3E78_RS02145	COG0667	Aldo Keto reductase
C3E78_RS02155	COG1309	transcriptional regulator
C3E78_RS02185	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C3E78_RS02195	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C3E78_RS02200	COG1216	Glycosyl transferase, family 2
C3E78_RS02210	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C3E78_RS02210	COG2755	lipolytic protein G-D-S-L family
C3E78_RS02225	COG1215	transferase activity, transferring glycosyl groups
C3E78_RS02250	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C3E78_RS02255	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS02265	COG2267	carboxylic ester hydrolase activity
C3E78_RS02280	COG0640	Transcriptional regulator
C3E78_RS02300	COG1316	TRANSCRIPTIONal
C3E78_RS02385	COG2176	DNA-directed DNA polymerase activity
C3E78_RS02410	COG0069	glutamate synthase activity
C3E78_RS02420	COG0745	RESPONSE REGULATOR receiver
C3E78_RS02455	COG0477	Major facilitator Superfamily
C3E78_RS02470	COG0306	phosphate transporter
C3E78_RS02475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C3E78_RS02490	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C3E78_RS02505	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C3E78_RS02510	COG0657	acetylesterase activity
C3E78_RS02515	COG0456	acetyltransferase
C3E78_RS02525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C3E78_RS02535	COG2186	Transcriptional regulator
C3E78_RS02540	COG0730	response to heat
C3E78_RS02545	COG0745	RESPONSE REGULATOR receiver
C3E78_RS02580	COG0438	transferase activity, transferring glycosyl groups
C3E78_RS02595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C3E78_RS02600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C3E78_RS02605	COG1086	Polysaccharide biosynthesis protein
C3E78_RS02610	COG0489	protein tyrosine kinase activity
C3E78_RS02640	COG1490	D-aminoacyl-tRNA deacylase activity
C3E78_RS02645	COG4044	May play a role in the intracellular transport of hydrophobic ligands
C3E78_RS02660	COG0489	protein tyrosine kinase activity
C3E78_RS02675	COG0662	Cupin 2, conserved barrel domain protein
C3E78_RS02675	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C3E78_RS02720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C3E78_RS02750	COG1217	gtp-binding protein TYPA
C3E78_RS02760	COG0477	Major facilitator Superfamily
C3E78_RS02765	COG0318	PFAM AMP-dependent synthetase and ligase
C3E78_RS02775	COG0438	transferase activity, transferring glycosyl groups
C3E78_RS02790	COG0588	phosphoglycerate mutase activity
C3E78_RS02815	COG1329	Transcriptional regulator
C3E78_RS02820	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C3E78_RS02835	COG0215	cysteine-tRNA ligase activity
C3E78_RS02845	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS02880	COG0318	PFAM AMP-dependent synthetase and ligase
C3E78_RS02885	COG1024	Enoyl-CoA hydratase
C3E78_RS02895	COG1960	acyl-CoA dehydrogenase activity
C3E78_RS02900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C3E78_RS02905	COG1064	alcohol dehydrogenase
C3E78_RS02930	COG0183	Belongs to the thiolase family
C3E78_RS02935	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS02945	COG1309	transcriptional regulator
C3E78_RS02985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3E78_RS02990	COG4603	Belongs to the binding-protein-dependent transport system permease family
C3E78_RS02995	COG1079	Belongs to the binding-protein-dependent transport system permease family
C3E78_RS03015	COG1414	Transcriptional regulator
C3E78_RS03055	COG1309	transcriptional regulator
C3E78_RS03060	COG0300	oxidoreductase activity
C3E78_RS03075	COG0076	glutamate decarboxylase activity
C3E78_RS03085	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS03090	COG1902	pentaerythritol trinitrate reductase activity
C3E78_RS03120	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C3E78_RS03125	COG3340	Belongs to the peptidase S51 family
C3E78_RS03135	COG0628	permease
C3E78_RS03140	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C3E78_RS03145	COG2223	nitrite transmembrane transporter activity
C3E78_RS03155	COG0686	Belongs to the AlaDH PNT family
C3E78_RS03180	COG0076	glutamate decarboxylase activity
C3E78_RS03190	COG0488	(ABC) transporter
C3E78_RS03195	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C3E78_RS03230	COG1278	Cold shock
C3E78_RS03265	COG0459	protein refolding
C3E78_RS03270	COG3483	tryptophan 2,3-dioxygenase activity
C3E78_RS03285	COG1045	serine acetyltransferase
C3E78_RS03345	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C3E78_RS03350	COG0318	PFAM AMP-dependent synthetase and ligase
C3E78_RS03360	COG1595	DNA-templated transcription, initiation
C3E78_RS03380	COG2814	Major facilitator Superfamily
C3E78_RS03405	COG2252	PERMEase
C3E78_RS03440	COG1305	Transglutaminase-like
C3E78_RS03450	COG1215	transferase activity, transferring glycosyl groups
C3E78_RS03460	COG0259	pyridoxamine-phosphate oxidase activity
C3E78_RS03500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3E78_RS03515	COG1404	Belongs to the peptidase S8 family
C3E78_RS03575	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C3E78_RS03590	COG0315	cyclic pyranopterin monophosphate synthase activity
C3E78_RS03595	COG0521	Mo-molybdopterin cofactor biosynthetic process
C3E78_RS03660	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C3E78_RS03670	COG1773	rubredoxin
C3E78_RS03700	COG5001	Diguanylate cyclase
C3E78_RS03720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3E78_RS03725	COG0084	hydrolase, TatD family'
C3E78_RS03735	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C3E78_RS03740	COG3619	membrane
C3E78_RS03750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C3E78_RS03760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C3E78_RS03770	COG0488	(ABC) transporter
C3E78_RS03785	COG4106	trans-aconitate 2-methyltransferase activity
C3E78_RS03795	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C3E78_RS03810	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C3E78_RS03815	COG0193	aminoacyl-tRNA hydrolase activity
C3E78_RS03820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C3E78_RS03865	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C3E78_RS03900	COG0438	transferase activity, transferring glycosyl groups
C3E78_RS03925	COG1215	transferase activity, transferring glycosyl groups
C3E78_RS03935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C3E78_RS03960	COG1316	TRANSCRIPTIONal
C3E78_RS03980	COG0531	amino acid
C3E78_RS03995	COG0148	phosphopyruvate hydratase activity
C3E78_RS04020	COG3250	beta-galactosidase activity
C3E78_RS04025	COG3250	beta-galactosidase activity
C3E78_RS04030	COG0246	Mannitol dehydrogenase
C3E78_RS04040	COG1609	Transcriptional regulator
C3E78_RS04045	COG1129	ABC transporter
C3E78_RS04050	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3E78_RS04075	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS04075	COG3347	Dehydrogenase
C3E78_RS04080	COG1070	Carbohydrate kinase
C3E78_RS04095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C3E78_RS04100	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C3E78_RS04105	COG2086	electron transfer activity
C3E78_RS04120	COG4176	ABC-type proline glycine betaine transport system permease component
C3E78_RS04125	COG4175	Glycine betaine
C3E78_RS04125	COG0517	IMP dehydrogenase activity
C3E78_RS04135	COG1012	belongs to the aldehyde dehydrogenase family
C3E78_RS04140	COG1414	Transcriptional regulator
C3E78_RS04150	COG5598	trimethylamine methyltransferase
C3E78_RS04160	COG5012	cobalamin binding
C3E78_RS04195	COG0667	Aldo Keto reductase
C3E78_RS04215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C3E78_RS04225	COG2755	lipolytic protein G-D-S-L family
C3E78_RS04250	COG0702	epimerase
C3E78_RS04255	COG1733	regulation of RNA biosynthetic process
C3E78_RS04265	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3E78_RS04275	COG2315	Protein conserved in bacteria
C3E78_RS04330	COG1846	Transcriptional regulator
C3E78_RS04335	COG2409	Drug exporters of the RND superfamily
C3E78_RS04355	COG0444	Belongs to the ABC transporter superfamily
C3E78_RS04380	COG4948	Mandelate Racemase Muconate Lactonizing
C3E78_RS04395	COG1136	(ABC) transporter
C3E78_RS04405	COG2197	response regulator
C3E78_RS04415	COG1522	sequence-specific DNA binding
C3E78_RS04430	COG1215	transferase activity, transferring glycosyl groups
C3E78_RS04450	COG1902	pentaerythritol trinitrate reductase activity
C3E78_RS04485	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C3E78_RS04490	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS04530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C3E78_RS04535	COG1309	transcriptional regulator
C3E78_RS04540	COG2814	Major facilitator Superfamily
C3E78_RS04555	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C3E78_RS04575	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C3E78_RS04580	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C3E78_RS04585	COG1695	Transcriptional regulator
C3E78_RS04590	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C3E78_RS04595	COG0483	inositol monophosphate 1-phosphatase activity
C3E78_RS04605	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C3E78_RS04615	COG2135	peptidase activity
C3E78_RS04620	COG1595	DNA-templated transcription, initiation
C3E78_RS04655	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C3E78_RS04670	COG0673	inositol 2-dehydrogenase activity
C3E78_RS04675	COG1879	ABC-type sugar transport system periplasmic component
C3E78_RS04680	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3E78_RS04685	COG1129	ABC transporter
C3E78_RS04690	COG1940	carbohydrate kinase activity
C3E78_RS04695	COG2884	Cell division ATP-binding protein ftsE
C3E78_RS04700	COG2177	Part of the ABC transporter FtsEX involved in
C3E78_RS04715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C3E78_RS04740	COG2154	pterin-4-alpha-carbinolamine dehydratase
C3E78_RS04750	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C3E78_RS04755	COG1201	RNA secondary structure unwinding
C3E78_RS04775	COG1470	cell adhesion involved in biofilm formation
C3E78_RS04780	COG1309	transcriptional regulator
C3E78_RS04795	COG1678	Uncharacterized ACR, COG1678
C3E78_RS04830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3E78_RS04840	COG4552	Acetyltransferase involved in intracellular survival and related
C3E78_RS04845	COG1335	isochorismatase
C3E78_RS04855	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C3E78_RS04885	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C3E78_RS04890	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C3E78_RS04895	COG1234	tRNA 3'-trailer cleavage
C3E78_RS04900	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C3E78_RS04905	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C3E78_RS04920	COG3135	benzoate transporter
C3E78_RS04960	COG4129	membrane
C3E78_RS04965	COG1785	Belongs to the alkaline phosphatase family
C3E78_RS04975	COG2301	Belongs to the HpcH HpaI aldolase family
C3E78_RS04990	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C3E78_RS04995	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C3E78_RS05000	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C3E78_RS05025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C3E78_RS05055	COG0406	alpha-ribazole phosphatase activity
C3E78_RS05060	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C3E78_RS05065	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C3E78_RS05090	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3E78_RS05095	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3E78_RS05115	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C3E78_RS05135	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C3E78_RS05160	COG2353	YceI-like domain
C3E78_RS05170	COG1960	acyl-CoA dehydrogenase activity
C3E78_RS05175	COG0183	Belongs to the thiolase family
C3E78_RS05180	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS05185	COG2030	dehydratase
C3E78_RS05190	COG0736	holo-[acyl-carrier-protein] synthase activity
C3E78_RS05200	COG1472	Belongs to the glycosyl hydrolase 3 family
C3E78_RS05220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3E78_RS05225	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C3E78_RS05235	COG2346	COG2346, Truncated hemoglobins
C3E78_RS05240	COG0668	transmembrane transport
C3E78_RS05255	COG1960	acyl-CoA dehydrogenase activity
C3E78_RS05270	COG1215	transferase activity, transferring glycosyl groups
C3E78_RS05275	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C3E78_RS05285	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C3E78_RS05290	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C3E78_RS05335	COG0544	peptidyl-prolyl cis-trans isomerase activity
C3E78_RS05355	COG2188	Transcriptional regulator
C3E78_RS05365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3E78_RS05375	COG3718	enzyme involved in inositol metabolism
C3E78_RS05380	COG3962	Belongs to the TPP enzyme family
C3E78_RS05410	COG0673	inositol 2-dehydrogenase activity
C3E78_RS05420	COG0673	inositol 2-dehydrogenase activity
C3E78_RS05425	COG3622	Belongs to the hyi family
C3E78_RS05440	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS05445	COG0740	serine-type endopeptidase activity
C3E78_RS05450	COG0740	serine-type endopeptidase activity
C3E78_RS05455	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C3E78_RS05460	COG3268	Saccharopine dehydrogenase
C3E78_RS05465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3E78_RS05475	COG1349	DNA-binding transcription factor activity
C3E78_RS05480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C3E78_RS05485	COG1063	alcohol dehydrogenase
C3E78_RS05490	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3E78_RS05505	COG1271	oxidase subunit
C3E78_RS05515	COG0525	valine-tRNA ligase activity
C3E78_RS05520	COG2409	Drug exporters of the RND superfamily
C3E78_RS05525	COG0285	dihydrofolate synthase activity
C3E78_RS05565	COG0366	Alpha amylase catalytic
C3E78_RS05570	COG0105	UTP biosynthetic process
C3E78_RS05595	COG2226	methyltransferase
C3E78_RS05610	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C3E78_RS05615	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C3E78_RS05630	COG2807	transmembrane transport
C3E78_RS05640	COG1530	ribonuclease E activity
C3E78_RS05645	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C3E78_RS05650	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C3E78_RS05655	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C3E78_RS05660	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C3E78_RS05665	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C3E78_RS05670	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C3E78_RS05675	COG0799	negative regulation of ribosome biogenesis
C3E78_RS05680	COG0406	alpha-ribazole phosphatase activity
C3E78_RS05720	COG0477	Major facilitator Superfamily
C3E78_RS05725	COG3590	peptidase
C3E78_RS05765	COG1216	Glycosyl transferase, family 2
C3E78_RS05775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C3E78_RS05780	COG0569	domain protein
C3E78_RS05805	COG0495	leucyl-tRNA aminoacylation
C3E78_RS05810	COG1307	EDD domain protein, DegV family
C3E78_RS05815	COG1596	polysaccharide export
C3E78_RS05815	COG1555	photosystem II stabilization
C3E78_RS05820	COG2333	competence protein COMEC
C3E78_RS05820	COG0658	competence protein
C3E78_RS05825	COG0420	3'-5' exonuclease activity
C3E78_RS05830	COG0419	ATPase involved in DNA repair
C3E78_RS05845	COG0268	Binds directly to 16S ribosomal RNA
C3E78_RS05850	COG0481	GTPase activity
C3E78_RS05860	COG1022	Amp-dependent synthetase and ligase
C3E78_RS05885	COG1420	regulation of RNA biosynthetic process
C3E78_RS05890	COG0484	heat shock protein binding
C3E78_RS05895	COG0537	adenosine 5'-monophosphoramidase activity
C3E78_RS05905	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C3E78_RS05920	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C3E78_RS05935	COG1254	Belongs to the acylphosphatase family
C3E78_RS05945	COG0514	ATP-dependent DNA helicase (RecQ)
C3E78_RS05975	COG0714	Associated with various cellular activities
C3E78_RS05990	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C3E78_RS05995	COG0435	Glutathione S-transferase
C3E78_RS06005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3E78_RS06015	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C3E78_RS06030	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C3E78_RS06035	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C3E78_RS06045	COG1012	belongs to the aldehyde dehydrogenase family
C3E78_RS06065	COG1381	Involved in DNA repair and RecF pathway recombination
C3E78_RS06070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3E78_RS06080	COG3634	alkyl hydroperoxide reductase activity
C3E78_RS06105	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3E78_RS06110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3E78_RS06140	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C3E78_RS06155	COG1414	Transcriptional regulator
C3E78_RS06160	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C3E78_RS06165	COG0066	3-isopropylmalate dehydratase activity
C3E78_RS06180	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C3E78_RS06185	COG0626	cystathionine gamma-synthase activity
C3E78_RS06190	COG1181	Belongs to the D-alanine--D-alanine ligase family
C3E78_RS06215	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C3E78_RS06220	COG1461	Dihydroxyacetone kinase
C3E78_RS06230	COG0742	ribosomal rna small subunit methyltransferase
C3E78_RS06235	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C3E78_RS06240	COG1595	DNA-templated transcription, initiation
C3E78_RS06250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C3E78_RS06260	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C3E78_RS06265	COG0571	ribonuclease III activity
C3E78_RS06270	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C3E78_RS06280	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C3E78_RS06300	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C3E78_RS06305	COG0583	DNA-binding transcription factor activity
C3E78_RS06310	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS06325	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C3E78_RS06370	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C3E78_RS06415	COG4585	Histidine kinase
C3E78_RS06420	COG2197	response regulator
C3E78_RS06430	COG0028	Belongs to the TPP enzyme family
C3E78_RS06445	COG2890	protein-(glutamine-N5) methyltransferase activity
C3E78_RS06450	COG0514	ATP-dependent DNA helicase (RecQ)
C3E78_RS06455	COG0667	Aldo Keto reductase
C3E78_RS06460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C3E78_RS06475	COG3022	response to hydroperoxide
C3E78_RS06485	COG2119	membrane
C3E78_RS06515	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C3E78_RS06520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3E78_RS06520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C3E78_RS06535	COG4941	Belongs to the sigma-70 factor family
C3E78_RS06545	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C3E78_RS06590	COG1366	Belongs to the anti-sigma-factor antagonist family
C3E78_RS06615	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C3E78_RS06625	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C3E78_RS06630	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS06655	COG1414	Transcriptional regulator
C3E78_RS06670	COG0702	epimerase
C3E78_RS06710	COG0604	alcohol dehydrogenase
C3E78_RS06725	COG1742	UPF0060 membrane protein
C3E78_RS06735	COG2409	Drug exporters of the RND superfamily
C3E78_RS06750	COG2409	Drug exporters of the RND superfamily
C3E78_RS06755	COG4585	Histidine kinase
C3E78_RS06760	COG2197	response regulator
C3E78_RS06775	COG3177	Filamentation induced by cAMP protein fic
C3E78_RS06790	COG1937	Protein conserved in bacteria
C3E78_RS06795	COG0174	glutamine synthetase
C3E78_RS06815	COG4585	Histidine kinase
C3E78_RS06820	COG2197	response regulator
C3E78_RS06825	COG4152	abc transporter atp-binding protein
C3E78_RS06835	COG0321	lipoyl(octanoyl) transferase activity
C3E78_RS06860	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C3E78_RS06875	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3E78_RS06880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3E78_RS06895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C3E78_RS06900	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C3E78_RS06920	COG0501	Belongs to the peptidase M48B family
C3E78_RS06930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3E78_RS06945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3E78_RS06950	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C3E78_RS06955	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C3E78_RS06965	COG1376	ErfK ybiS ycfS ynhG family protein
C3E78_RS06970	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C3E78_RS06975	COG0723	plastoquinol--plastocyanin reductase activity
C3E78_RS06980	COG2010	Cytochrome c
C3E78_RS06985	COG1845	cytochrome c oxidase, subunit III
C3E78_RS06995	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C3E78_RS07015	COG0791	NLP P60 protein
C3E78_RS07025	COG1022	Amp-dependent synthetase and ligase
C3E78_RS07040	COG1940	carbohydrate kinase activity
C3E78_RS07045	COG1940	carbohydrate kinase activity
C3E78_RS07060	COG0205	6-phosphofructokinase activity
C3E78_RS07070	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C3E78_RS07075	COG0515	serine threonine protein kinase
C3E78_RS07075	COG2815	serine threonine protein kinase
C3E78_RS07080	COG0142	geranyltranstransferase activity
C3E78_RS07090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3E78_RS07095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C3E78_RS07105	COG2001	Belongs to the MraZ family
C3E78_RS07110	COG0275	rRNA processing
C3E78_RS07120	COG0768	penicillin binding
C3E78_RS07125	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C3E78_RS07130	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C3E78_RS07135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3E78_RS07140	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C3E78_RS07150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3E78_RS07155	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C3E78_RS07160	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C3E78_RS07165	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C3E78_RS07180	COG1799	cell septum assembly
C3E78_RS07195	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C3E78_RS07200	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C3E78_RS07240	COG0587	DNA-directed DNA polymerase activity
C3E78_RS07250	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C3E78_RS07255	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C3E78_RS07260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3E78_RS07265	COG0131	Imidazoleglycerol-phosphate dehydratase
C3E78_RS07270	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C3E78_RS07290	COG0107	imidazoleglycerol-phosphate synthase activity
C3E78_RS07295	COG1132	(ABC) transporter
C3E78_RS07300	COG1132	(ABC) transporter
C3E78_RS07305	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C3E78_RS07320	COG1714	RDD family
C3E78_RS07330	COG0134	indole-3-glycerol-phosphate synthase activity
C3E78_RS07335	COG0133	tryptophan synthase activity
C3E78_RS07340	COG0159	tryptophan synthase activity
C3E78_RS07345	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C3E78_RS07365	COG0069	glutamate synthase activity
C3E78_RS07365	COG0070	glutamate synthase
C3E78_RS07365	COG0067	glutamate synthase
C3E78_RS07375	COG0469	pyruvate kinase activity
C3E78_RS07390	COG0683	leucine binding
C3E78_RS07420	COG1811	Na channel or pump
C3E78_RS07450	COG1362	aminopeptidase activity
C3E78_RS07455	COG0539	negative regulation of cytoplasmic translation
C3E78_RS07470	COG0237	dephospho-CoA kinase activity
C3E78_RS07475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C3E78_RS07485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C3E78_RS07505	COG0114	fumarate hydratase activity
C3E78_RS07535	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C3E78_RS07535	COG2755	lipolytic protein G-D-S-L family
C3E78_RS07545	COG0477	Major facilitator Superfamily
C3E78_RS07555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C3E78_RS07575	COG1435	thymidine kinase activity
C3E78_RS07585	COG2860	membrane
C3E78_RS07590	COG1012	belongs to the aldehyde dehydrogenase family
C3E78_RS07600	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C3E78_RS07625	COG0756	dUTP diphosphatase activity
C3E78_RS07650	COG0569	domain protein
C3E78_RS07655	COG0531	amino acid
C3E78_RS07660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C3E78_RS07680	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C3E78_RS07690	COG4213	ABC transporter substrate-binding protein
C3E78_RS07700	COG4214	carbohydrate transport
C3E78_RS07715	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C3E78_RS07775	COG3655	Transcriptional regulator
C3E78_RS07780	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C3E78_RS07795	COG3250	beta-galactosidase activity
C3E78_RS07805	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C3E78_RS07820	COG1309	transcriptional regulator
C3E78_RS07825	COG0667	Aldo Keto reductase
C3E78_RS07915	COG1755	Isoprenylcysteine carboxyl methyltransferase
C3E78_RS07935	COG0596	Alpha beta hydrolase
C3E78_RS07950	COG4585	Histidine kinase
C3E78_RS07955	COG2197	response regulator
C3E78_RS08055	COG1940	carbohydrate kinase activity
C3E78_RS08065	COG1070	Carbohydrate kinase
C3E78_RS08080	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C3E78_RS08090	COG1946	Acyl-CoA thioesterase
C3E78_RS08095	COG2030	dehydratase
C3E78_RS08115	COG0556	nucleotide-excision repair
C3E78_RS08135	COG0531	amino acid
C3E78_RS08140	COG2124	cytochrome p450
C3E78_RS08185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3E78_RS08190	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C3E78_RS08195	COG2354	Protein conserved in bacteria
C3E78_RS08200	COG0322	excinuclease ABC activity
C3E78_RS08205	COG1660	Displays ATPase and GTPase activities
C3E78_RS08215	COG1481	regulation of sporulation
C3E78_RS08220	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C3E78_RS08225	COG0126	phosphoglycerate kinase activity
C3E78_RS08230	COG0149	triose-phosphate isomerase activity
C3E78_RS08235	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C3E78_RS08245	COG0363	glucosamine-6-phosphate deaminase activity
C3E78_RS08260	COG0166	Belongs to the GPI family
C3E78_RS08265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C3E78_RS08275	COG0109	protoheme IX farnesyltransferase activity
C3E78_RS08305	COG2130	NADP-dependent
C3E78_RS08310	COG2508	Transcriptional regulator
C3E78_RS08355	COG1793	dna ligase
C3E78_RS08360	COG2357	RelA SpoT domain protein
C3E78_RS08395	COG0396	ATPase activity
C3E78_RS08400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C3E78_RS08405	COG0822	iron-sulfur transferase activity
C3E78_RS08410	COG2151	metal-sulfur cluster biosynthetic enzyme
C3E78_RS08415	COG0488	(ABC) transporter
C3E78_RS08425	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C3E78_RS08440	COG3360	Dodecin
C3E78_RS08450	COG0640	Transcriptional regulator
C3E78_RS08455	COG0560	Phosphoserine phosphatase
C3E78_RS08455	COG3830	Belongs to the UPF0237 family
C3E78_RS08460	COG1119	ATPase activity
C3E78_RS08480	COG1881	PFAM PEBP family protein
C3E78_RS08495	COG0242	peptide deformylase activity
C3E78_RS08500	COG1960	acyl-CoA dehydrogenase activity
C3E78_RS08505	COG1960	acyl-CoA dehydrogenase activity
C3E78_RS08510	COG1846	Transcriptional regulator
C3E78_RS08525	COG0545	Peptidyl-prolyl cis-trans isomerase
C3E78_RS08530	COG1643	Atp-dependent helicase
C3E78_RS08545	COG2733	membrane
C3E78_RS08575	COG1902	pentaerythritol trinitrate reductase activity
C3E78_RS08595	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS08600	COG1309	transcriptional regulator
C3E78_RS08620	COG1131	(ABC) transporter
C3E78_RS08630	COG2267	carboxylic ester hydrolase activity
C3E78_RS08645	COG2066	Belongs to the glutaminase family
C3E78_RS08655	COG1063	alcohol dehydrogenase
C3E78_RS08660	COG0604	alcohol dehydrogenase
C3E78_RS08670	COG1309	transcriptional regulator
C3E78_RS08675	COG2409	Drug exporters of the RND superfamily
C3E78_RS08680	COG2197	response regulator
C3E78_RS08705	COG1309	transcriptional regulator
C3E78_RS08715	COG1733	regulation of RNA biosynthetic process
C3E78_RS08730	COG0438	transferase activity, transferring glycosyl groups
C3E78_RS08735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C3E78_RS08740	COG3588	fructose-bisphosphate aldolase
C3E78_RS08750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3E78_RS08755	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C3E78_RS08800	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C3E78_RS08810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3E78_RS08820	COG2072	flavoprotein involved in K transport
C3E78_RS08825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3E78_RS08830	COG0438	transferase activity, transferring glycosyl groups
C3E78_RS08865	COG2409	Drug exporters of the RND superfamily
C3E78_RS08895	COG1120	ATPase activity
C3E78_RS08900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3E78_RS08910	COG0300	oxidoreductase activity
C3E78_RS08940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C3E78_RS08960	COG3842	ATPase activity
C3E78_RS08970	COG0135	phosphoribosylanthranilate isomerase activity
C3E78_RS08985	COG0831	urea catabolic process
C3E78_RS09000	COG0804	urea catabolic process
C3E78_RS09005	COG0830	nickel cation binding
C3E78_RS09010	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C3E78_RS09015	COG0829	nickel cation binding
C3E78_RS09020	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C3E78_RS09030	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3E78_RS09035	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3E78_RS09040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3E78_RS09055	COG0549	Belongs to the carbamate kinase family
C3E78_RS09060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C3E78_RS09065	COG2235	arginine
C3E78_RS09070	COG1288	antiporter activity
C3E78_RS09090	COG0071	Belongs to the small heat shock protein (HSP20) family
C3E78_RS09110	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
C3E78_RS09130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C3E78_RS09180	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C3E78_RS09190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3E78_RS09215	COG0667	Aldo Keto reductase
C3E78_RS09220	COG1968	undecaprenyl-diphosphatase activity
C3E78_RS09225	COG0598	Magnesium transport protein CorA
C3E78_RS09230	COG0215	cysteine-tRNA ligase activity
C3E78_RS09255	COG0646	methionine synthase
C3E78_RS09255	COG1410	methionine synthase
C3E78_RS09260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3E78_RS09265	COG0517	IMP dehydrogenase activity
C3E78_RS09265	COG1994	Peptidase M50
C3E78_RS09275	COG1222	aaa ATPase
C3E78_RS09295	COG4122	O-methyltransferase activity
C3E78_RS09300	COG1120	ATPase activity
C3E78_RS09305	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3E78_RS09310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3E78_RS09325	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C3E78_RS09330	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C3E78_RS09335	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C3E78_RS09355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3E78_RS09360	COG0805	protein transport
C3E78_RS09375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3E78_RS09395	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C3E78_RS09400	COG0463	Glycosyl transferase, family 2
C3E78_RS09420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C3E78_RS09425	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C3E78_RS09475	COG1309	transcriptional regulator
C3E78_RS09480	COG0154	amidase activity
C3E78_RS09495	COG2084	Dehydrogenase
C3E78_RS09505	COG4221	oxidoreductase activity
C3E78_RS09510	COG2936	dipeptidyl-peptidase activity
C3E78_RS09520	COG0583	DNA-binding transcription factor activity
C3E78_RS09545	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3E78_RS09570	COG0009	L-threonylcarbamoyladenylate synthase
C3E78_RS09575	COG0175	sulfate reduction
C3E78_RS09590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C3E78_RS09590	COG1648	precorrin-2 dehydrogenase activity
C3E78_RS09625	COG1960	acyl-CoA dehydrogenase activity
C3E78_RS09630	COG1595	DNA-templated transcription, initiation
C3E78_RS09650	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3E78_RS09650	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3E78_RS09700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C3E78_RS09725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3E78_RS09750	COG1119	ATPase activity
C3E78_RS09760	COG2501	S4 domain
C3E78_RS09770	COG0494	nUDIX hydrolase
C3E78_RS09800	COG2249	NAD(P)H dehydrogenase (quinone) activity
C3E78_RS09845	COG1160	GTP binding
C3E78_RS09855	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C3E78_RS09870	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C3E78_RS09895	COG0494	nUDIX hydrolase
C3E78_RS09900	COG0504	CTP synthase activity
C3E78_RS09915	COG0497	DNA recombination
C3E78_RS09920	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C3E78_RS09935	COG0647	UMP catabolic process
C3E78_RS09965	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C3E78_RS09970	COG0589	response to stress
C3E78_RS09980	COG0589	response to stress
C3E78_RS10000	COG3290	protein histidine kinase activity
C3E78_RS10005	COG4565	transcriptional regulatory protein
C3E78_RS10010	COG2094	Belongs to the DNA glycosylase MPG family
C3E78_RS10015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C3E78_RS10020	COG0165	Argininosuccinate lyase
C3E78_RS10025	COG1438	arginine binding
C3E78_RS10030	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C3E78_RS10035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3E78_RS10040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C3E78_RS10045	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C3E78_RS10050	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C3E78_RS10055	COG0137	argininosuccinate synthase activity
C3E78_RS10065	COG0072	phenylalanine-tRNA ligase activity
C3E78_RS10065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3E78_RS10070	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C3E78_RS10075	COG5002	protein histidine kinase activity
C3E78_RS10080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3E78_RS10085	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C3E78_RS10090	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C3E78_RS10095	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C3E78_RS10120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C3E78_RS10125	COG0140	phosphoribosyl-ATP diphosphatase activity
C3E78_RS10130	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C3E78_RS10135	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3E78_RS10135	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3E78_RS10150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C3E78_RS10165	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C3E78_RS10175	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C3E78_RS10185	COG1758	RNA polymerase activity
C3E78_RS10190	COG0194	GDP metabolic process
C3E78_RS10205	COG0284	orotidine-5'-phosphate decarboxylase activity
C3E78_RS10210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C3E78_RS10215	COG0505	Belongs to the CarA family
C3E78_RS10220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3E78_RS10225	COG0540	Belongs to the ATCase OTCase family
C3E78_RS10235	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C3E78_RS10240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C3E78_RS10245	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C3E78_RS10250	COG0006	proline dipeptidase activity
C3E78_RS10255	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C3E78_RS10260	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C3E78_RS10265	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C3E78_RS10285	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C3E78_RS10290	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C3E78_RS10310	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C3E78_RS10315	COG0124	histidyl-tRNA synthetase
C3E78_RS10325	COG1196	nuclear chromosome segregation
C3E78_RS10335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C3E78_RS10340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C3E78_RS10345	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3E78_RS10350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3E78_RS10355	COG1862	Preprotein translocase
C3E78_RS10360	COG2255	four-way junction helicase activity
C3E78_RS10365	COG0632	four-way junction helicase activity
C3E78_RS10370	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C3E78_RS10375	COG0217	transcriptional regulatory protein
C3E78_RS10380	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C3E78_RS10385	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C3E78_RS10400	COG0659	secondary active sulfate transmembrane transporter activity
C3E78_RS10405	COG0789	Transcriptional regulator
C3E78_RS10410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C3E78_RS10420	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C3E78_RS10425	COG2197	response regulator
C3E78_RS10445	COG2072	flavoprotein involved in K transport
C3E78_RS10465	COG1131	(ABC) transporter
C3E78_RS10480	COG1902	pentaerythritol trinitrate reductase activity
C3E78_RS10510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3E78_RS10540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C3E78_RS10575	COG1960	acyl-CoA dehydrogenase activity
C3E78_RS10605	COG3180	Ammonia monooxygenase
C3E78_RS10610	COG2326	polyphosphate kinase activity
C3E78_RS10615	COG2197	response regulator
C3E78_RS10630	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3E78_RS10635	COG3253	May function as heme-dependent peroxidase
C3E78_RS10645	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C3E78_RS10670	COG0667	Aldo Keto reductase
C3E78_RS10680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3E78_RS10730	COG2249	NAD(P)H dehydrogenase (quinone) activity
C3E78_RS10745	COG0343	queuine tRNA-ribosyltransferase activity
C3E78_RS10755	COG0644	oxidoreductase
C3E78_RS10795	COG2814	Major facilitator Superfamily
C3E78_RS10810	COG1278	Cold shock
C3E78_RS10815	COG2133	pyrroloquinoline quinone binding
C3E78_RS10825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3E78_RS10865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C3E78_RS10910	COG2815	serine threonine protein kinase
C3E78_RS10910	COG0515	serine threonine protein kinase
C3E78_RS10930	COG0604	alcohol dehydrogenase
C3E78_RS10940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C3E78_RS10945	COG4221	oxidoreductase activity
C3E78_RS10955	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C3E78_RS10960	COG1074	ATP-dependent DNA helicase activity
C3E78_RS10965	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C3E78_RS10985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3E78_RS10995	COG1253	flavin adenine dinucleotide binding
C3E78_RS11000	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3E78_RS11005	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C3E78_RS11015	COG2261	transglycosylase associated protein
C3E78_RS11020	COG0783	Belongs to the Dps family
C3E78_RS11030	COG0519	Catalyzes the synthesis of GMP from XMP
C3E78_RS11030	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C3E78_RS11040	COG1295	ribonuclease BN
C3E78_RS11050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C3E78_RS11075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C3E78_RS11080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C3E78_RS11085	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C3E78_RS11105	COG1309	transcriptional regulator
C3E78_RS11110	COG2409	Drug exporters of the RND superfamily
C3E78_RS11125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3E78_RS11185	COG2137	regulation of response to DNA damage stimulus
C3E78_RS11190	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C3E78_RS11210	COG0395	ABC-type sugar transport system, permease component
C3E78_RS11215	COG1175	transmembrane transport
C3E78_RS11225	COG3842	ATPase activity
C3E78_RS11240	COG1546	Belongs to the CinA family
C3E78_RS11240	COG1058	Belongs to the CinA family
C3E78_RS11255	COG1674	ftsk spoiiie
C3E78_RS11265	COG0303	'Molybdopterin
C3E78_RS11280	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C3E78_RS11285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3E78_RS11315	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C3E78_RS11340	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C3E78_RS11380	COG5002	protein histidine kinase activity
C3E78_RS11400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C3E78_RS11405	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C3E78_RS11410	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C3E78_RS11415	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C3E78_RS11430	COG0779	Required for maturation of 30S ribosomal subunits
C3E78_RS11445	COG0442	prolyl-tRNA aminoacylation
C3E78_RS11465	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C3E78_RS11470	COG0750	zinc metalloprotease
C3E78_RS11485	COG1131	(ABC) transporter
C3E78_RS11490	COG4585	Histidine kinase
C3E78_RS11495	COG2197	response regulator
C3E78_RS11515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C3E78_RS11520	COG1177	transmembrane transport
C3E78_RS11525	COG1176	ABC-type spermidine putrescine transport system, permease component I
C3E78_RS11530	COG3842	ATPase activity
C3E78_RS11560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C3E78_RS11575	COG2308	Evidence 4 Homologs of previously reported genes of
C3E78_RS11575	COG2307	Protein conserved in bacteria
C3E78_RS11590	COG0233	cytoplasmic translational termination
C3E78_RS11595	COG0528	UMP kinase activity
C3E78_RS11600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C3E78_RS11605	COG0052	Belongs to the universal ribosomal protein uS2 family
C3E78_RS11610	COG0739	heme binding
C3E78_RS11610	COG0741	lytic transglycosylase activity
C3E78_RS11610	COG1196	nuclear chromosome segregation
C3E78_RS11615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C3E78_RS11635	COG0792	nuclease activity
C3E78_RS11640	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C3E78_RS11650	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C3E78_RS11655	COG0681	Belongs to the peptidase S26 family
C3E78_RS11660	COG0681	Belongs to the peptidase S26 family
C3E78_RS11665	COG0335	large ribosomal subunit rRNA binding
C3E78_RS11675	COG0336	Belongs to the RNA methyltransferase TrmD family
C3E78_RS11680	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C3E78_RS11685	COG1837	Belongs to the UPF0109 family
C3E78_RS11690	COG0228	four-way junction DNA binding
C3E78_RS11705	COG1393	Belongs to the ArsC family
C3E78_RS11725	COG3265	gluconokinase activity
C3E78_RS11735	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C3E78_RS11755	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C3E78_RS11760	COG4988	ABC transporter
C3E78_RS11765	COG1294	oxidase, subunit
C3E78_RS11770	COG1271	oxidase subunit
C3E78_RS11815	COG2233	PERMEase
C3E78_RS11830	COG0423	glycine-tRNA ligase activity
C3E78_RS11840	COG1121	(ABC) transporter
C3E78_RS11845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3E78_RS11905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3E78_RS11915	COG1027	Aspartate ammonia-lyase
C3E78_RS11920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C3E78_RS11925	COG0473	3-isopropylmalate dehydrogenase activity
C3E78_RS11955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C3E78_RS11960	COG0440	acetolactate synthase activity
C3E78_RS11990	COG0129	dihydroxy-acid dehydratase activity
C3E78_RS12020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C3E78_RS12035	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3E78_RS12040	COG0154	amidase activity
C3E78_RS12045	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3E78_RS12050	COG0596	Alpha beta hydrolase
C3E78_RS12065	COG0564	pseudouridine synthase activity
C3E78_RS12085	COG0482	sulfurtransferase activity
C3E78_RS12095	COG1104	cysteine desulfurase activity
C3E78_RS12105	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C3E78_RS12110	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C3E78_RS12120	COG1793	dna ligase
C3E78_RS12140	COG2197	response regulator
C3E78_RS12150	COG0587	DNA-directed DNA polymerase activity
C3E78_RS12170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3E78_RS12180	COG4166	transmembrane transport
C3E78_RS12190	COG2086	electron transfer activity
C3E78_RS12210	COG2226	methyltransferase
C3E78_RS12225	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C3E78_RS12230	COG3281	Trehalose synthase
C3E78_RS12235	COG0366	Alpha amylase catalytic
C3E78_RS12240	COG0366	Alpha amylase catalytic
C3E78_RS12355	COG0183	Belongs to the thiolase family
C3E78_RS12385	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3E78_RS12395	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C3E78_RS12400	COG1528	Iron-storage protein
C3E78_RS12405	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C3E78_RS12405	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C3E78_RS12425	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C3E78_RS12430	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C3E78_RS12435	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C3E78_RS12440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C3E78_RS12445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3E78_RS12450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C3E78_RS12455	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3E78_RS12460	COG0356	it plays a direct role in the translocation of protons across the membrane
C3E78_RS12470	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3E78_RS12485	COG2890	protein-(glutamine-N5) methyltransferase activity
C3E78_RS12490	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C3E78_RS12495	COG0254	rRNA binding
C3E78_RS12500	COG0386	Belongs to the glutathione peroxidase family
C3E78_RS12510	COG0083	homoserine kinase activity
C3E78_RS12515	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C3E78_RS12520	COG0460	homoserine dehydrogenase
C3E78_RS12555	COG0018	arginyl-trna synthetase
C3E78_RS12560	COG0784	Response regulator, receiver
C3E78_RS12560	COG0643	Histidine kinase
C3E78_RS12560	COG2198	Histidine kinase
C3E78_RS12595	COG3979	chitinase
C3E78_RS12605	COG0567	Dehydrogenase, E1 component
C3E78_RS12605	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3E78_RS12610	COG0604	alcohol dehydrogenase
C3E78_RS12710	COG2318	DinB family
C3E78_RS12720	COG0745	RESPONSE REGULATOR receiver
C3E78_RS12725	COG2205	protein histidine kinase activity
C3E78_RS12730	COG1842	Phage shock protein A
C3E78_RS12780	COG0653	protein targeting
C3E78_RS12785	COG3214	Protein conserved in bacteria
C3E78_RS12790	COG2197	response regulator
C3E78_RS12795	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C3E78_RS12800	COG1040	competence protein
C3E78_RS12810	COG5000	phosphorelay sensor kinase activity
C3E78_RS12810	COG5002	protein histidine kinase activity
C3E78_RS12815	COG0745	RESPONSE REGULATOR receiver
C3E78_RS12820	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C3E78_RS12845	COG2835	tetraacyldisaccharide 4'-kinase activity
C3E78_RS12880	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C3E78_RS12895	COG1388	LysM domain
C3E78_RS12895	COG1134	teichoic acid transport
C3E78_RS12900	COG1316	TRANSCRIPTIONal
C3E78_RS12910	COG1316	TRANSCRIPTIONal
C3E78_RS12915	COG2171	N-acyltransferase activity
C3E78_RS12925	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS12970	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C3E78_RS12990	COG0277	FAD linked oxidase domain protein
C3E78_RS12995	COG0385	Bile acid
C3E78_RS13030	COG0328	RNA-DNA hybrid ribonuclease activity
C3E78_RS13040	COG1309	transcriptional regulator
C3E78_RS13070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3E78_RS13090	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C3E78_RS13100	COG1063	alcohol dehydrogenase
C3E78_RS13115	COG4221	oxidoreductase activity
C3E78_RS13130	COG0012	GTP binding
C3E78_RS13145	COG1322	Protein conserved in bacteria
C3E78_RS13160	COG0405	Gamma-glutamyltransferase
C3E78_RS13165	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C3E78_RS13175	COG1570	exodeoxyribonuclease VII activity
C3E78_RS13180	COG1722	exodeoxyribonuclease VII activity
C3E78_RS13200	COG2808	Putative FMN-binding domain
C3E78_RS13235	COG0114	fumarate hydratase activity
C3E78_RS13265	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C3E78_RS13270	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3E78_RS13280	COG1331	Highly conserved protein containing a thioredoxin domain
C3E78_RS13305	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C3E78_RS13315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C3E78_RS13320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C3E78_RS13350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3E78_RS13365	COG1846	Transcriptional regulator
C3E78_RS13370	COG0577	efflux transmembrane transporter activity
C3E78_RS13375	COG1136	(ABC) transporter
C3E78_RS13400	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C3E78_RS13405	COG1140	nitrate reductase beta subunit
C3E78_RS13415	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS13420	COG0384	phenazine biosynthesis protein PhzF
C3E78_RS13425	COG1233	COG1233 Phytoene dehydrogenase and related
C3E78_RS13440	COG3631	Ketosteroid isomerase-related protein
C3E78_RS13470	COG2066	Belongs to the glutaminase family
C3E78_RS13480	COG0515	serine threonine protein kinase
C3E78_RS13490	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS13515	COG1615	UPF0182 protein
C3E78_RS13525	COG3480	Lon protease (S16) C-terminal proteolytic domain
C3E78_RS13530	COG0314	molybdopterin synthase activity
C3E78_RS13555	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C3E78_RS13575	COG0210	DNA helicase
C3E78_RS13595	COG1309	transcriptional regulator
C3E78_RS13620	COG1192	Involved in chromosome partitioning
C3E78_RS13625	COG4221	oxidoreductase activity
C3E78_RS13635	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C3E78_RS13655	COG3069	C4-dicarboxylate transmembrane transporter activity
C3E78_RS13660	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS13665	COG0477	Major facilitator Superfamily
C3E78_RS13680	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3E78_RS13710	COG2508	Transcriptional regulator
C3E78_RS13725	COG0406	alpha-ribazole phosphatase activity
C3E78_RS13730	COG2030	dehydratase
C3E78_RS13740	COG1960	acyl-CoA dehydrogenase activity
C3E78_RS13750	COG1090	epimerase
C3E78_RS13760	COG0657	acetylesterase activity
C3E78_RS13780	COG0154	amidase activity
C3E78_RS13790	COG1309	transcriptional regulator
C3E78_RS13795	COG1064	alcohol dehydrogenase
C3E78_RS13800	COG2239	Acts as a magnesium transporter
C3E78_RS13810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C3E78_RS13815	COG0488	(ABC) transporter
C3E78_RS13825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3E78_RS13855	COG1024	Enoyl-CoA hydratase
C3E78_RS13865	COG0519	Catalyzes the synthesis of GMP from XMP
C3E78_RS13870	COG1611	Belongs to the LOG family
C3E78_RS13875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3E78_RS13885	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
C3E78_RS13910	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C3E78_RS13925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3E78_RS13940	COG0424	maF-like protein
C3E78_RS13950	COG1960	acyl-CoA dehydrogenase activity
C3E78_RS13955	COG4770	biotin carboxylase activity
C3E78_RS13970	COG2385	sporulation resulting in formation of a cellular spore
C3E78_RS13995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3E78_RS14015	COG4085	toxin activity
C3E78_RS14015	COG1525	nuclease
C3E78_RS14015	COG0737	Belongs to the 5'-nucleotidase family
C3E78_RS14035	COG3321	synthase
C3E78_RS14035	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS14035	COG0604	alcohol dehydrogenase
C3E78_RS14040	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS14045	COG1024	Enoyl-CoA hydratase
C3E78_RS14060	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS14070	COG1024	Enoyl-CoA hydratase
C3E78_RS14075	COG1960	acyl-CoA dehydrogenase activity
C3E78_RS14080	COG1960	acyl-CoA dehydrogenase activity
C3E78_RS14085	COG0045	succinate-CoA ligase (ADP-forming) activity
C3E78_RS14085	COG1042	CoA-binding domain protein
C3E78_RS14085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3E78_RS14115	COG1942	4-Oxalocrotonate Tautomerase
C3E78_RS14120	COG2188	Transcriptional regulator
C3E78_RS14130	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C3E78_RS14145	COG2124	cytochrome p450
C3E78_RS14155	COG1079	Belongs to the binding-protein-dependent transport system permease family
C3E78_RS14160	COG4603	Belongs to the binding-protein-dependent transport system permease family
C3E78_RS14165	COG3845	ABC transporter
C3E78_RS14170	COG1744	ABC transporter substrate-binding protein PnrA-like
C3E78_RS14175	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C3E78_RS14175	COG1473	amidohydrolase
C3E78_RS14190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C3E78_RS14195	COG1053	succinate dehydrogenase
C3E78_RS14215	COG0180	Tryptophanyl-tRNA synthetase
C3E78_RS14220	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C3E78_RS14225	COG1605	Chorismate mutase
C3E78_RS14225	COG0077	Prephenate dehydratase
C3E78_RS14245	COG0788	formyltetrahydrofolate deformylase activity
C3E78_RS14250	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C3E78_RS14255	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C3E78_RS14260	COG4208	sulfate ABC transporter
C3E78_RS14265	COG3842	ATPase activity
C3E78_RS14270	COG2814	Major facilitator Superfamily
C3E78_RS14280	COG2838	Isocitrate dehydrogenase
C3E78_RS14285	COG0039	L-malate dehydrogenase activity
C3E78_RS14295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C3E78_RS14310	COG0138	bifunctional purine biosynthesis protein purh
C3E78_RS14335	COG0045	succinate-CoA ligase (ADP-forming) activity
C3E78_RS14360	COG1725	Transcriptional regulator
C3E78_RS14375	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C3E78_RS14400	COG2197	response regulator
C3E78_RS14425	COG0584	glycerophosphoryl diester phosphodiesterase
C3E78_RS14430	COG0405	Gamma-glutamyltransferase
C3E78_RS14435	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C3E78_RS14440	COG3387	PFAM Glycoside hydrolase 15-related
C3E78_RS14445	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C3E78_RS14470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C3E78_RS14470	COG0519	Catalyzes the synthesis of GMP from XMP
C3E78_RS14500	COG2837	iron assimilation
C3E78_RS14520	COG0516	GMP reductase activity
C3E78_RS14545	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C3E78_RS14550	COG0459	protein refolding
C3E78_RS14555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C3E78_RS14570	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C3E78_RS14575	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C3E78_RS14585	COG1472	Belongs to the glycosyl hydrolase 3 family
C3E78_RS14590	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C3E78_RS14605	COG2318	DinB family
C3E78_RS14630	COG0456	acetyltransferase
C3E78_RS14630	COG1214	PFAM Peptidase M22, glycoprotease
C3E78_RS14635	COG0802	atpase or kinase
C3E78_RS14645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C3E78_RS14655	COG0736	holo-[acyl-carrier-protein] synthase activity
C3E78_RS14660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C3E78_RS14665	COG1072	(Pantothenic acid kinase))
C3E78_RS14685	COG0515	serine threonine protein kinase
C3E78_RS14685	COG2815	serine threonine protein kinase
C3E78_RS14690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3E78_RS14695	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C3E78_RS14700	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C3E78_RS14710	COG0101	tRNA pseudouridine synthase activity
C3E78_RS14740	COG0203	ribosomal protein L17
C3E78_RS14745	COG0202	RNA polymerase activity
C3E78_RS14750	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C3E78_RS14755	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C3E78_RS14760	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C3E78_RS14765	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C3E78_RS14770	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C3E78_RS14775	COG1522	sequence-specific DNA binding
C3E78_RS14780	COG1834	amidinotransferase
C3E78_RS14800	COG0563	adenylate kinase activity
C3E78_RS14810	COG0200	Binds to the 23S rRNA
C3E78_RS14815	COG1841	ribosomal large subunit assembly
C3E78_RS14820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C3E78_RS14825	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C3E78_RS14830	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C3E78_RS14835	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C3E78_RS14840	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C3E78_RS14845	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C3E78_RS14850	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C3E78_RS14855	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C3E78_RS14860	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C3E78_RS14865	COG0255	Belongs to the universal ribosomal protein uL29 family
C3E78_RS14870	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C3E78_RS14875	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C3E78_RS14880	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C3E78_RS14885	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C3E78_RS14890	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C3E78_RS14895	COG0089	rRNA binding
C3E78_RS14900	COG0088	Forms part of the polypeptide exit tunnel
C3E78_RS14905	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C3E78_RS14910	COG0051	transcription antitermination factor activity, RNA binding
C3E78_RS14925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C3E78_RS14930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C3E78_RS14935	COG0049	tRNA binding
C3E78_RS14940	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C3E78_RS14945	COG0247	lactate metabolic process
C3E78_RS14945	COG0277	FAD linked oxidase domain protein
C3E78_RS14965	COG0494	nUDIX hydrolase
C3E78_RS14970	COG3594	Acyltransferase
C3E78_RS14990	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C3E78_RS14995	COG0085	RNA polymerase activity
C3E78_RS15040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C3E78_RS15045	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C3E78_RS15055	COG0222	ribosome binding
C3E78_RS15075	COG0081	regulation of translation
C3E78_RS15080	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C3E78_RS15090	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C3E78_RS15115	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C3E78_RS15120	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C3E78_RS15140	COG0167	dihydroorotate dehydrogenase activity
C3E78_RS15150	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C3E78_RS15150	COG2066	Belongs to the glutaminase family
C3E78_RS15195	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS15205	COG1073	alpha beta
C3E78_RS15230	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C3E78_RS15255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C3E78_RS15285	COG3546	catalase activity
C3E78_RS15310	COG2259	Doxx family
C3E78_RS15315	COG3485	protocatechuate 3,4-dioxygenase
C3E78_RS15335	COG1414	Transcriptional regulator
C3E78_RS15350	COG1063	alcohol dehydrogenase
C3E78_RS15375	COG1320	monovalent cation:proton antiporter activity
C3E78_RS15390	COG0651	ATP synthesis coupled electron transport
C3E78_RS15395	COG1006	Multisubunit Na H antiporter MnhC subunit
C3E78_RS15400	COG2111	Na H antiporter
C3E78_RS15400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C3E78_RS15435	COG0535	radical SAM domain protein
C3E78_RS15455	COG1666	GTP binding
C3E78_RS15460	COG1007	ATP synthesis coupled electron transport
C3E78_RS15475	COG0713	ATP synthesis coupled electron transport
C3E78_RS15480	COG0839	Belongs to the complex I subunit 6 family
C3E78_RS15485	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3E78_RS15500	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3E78_RS15505	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3E78_RS15510	COG4221	oxidoreductase activity
C3E78_RS15525	COG0142	geranyltranstransferase activity
C3E78_RS15530	COG1007	ATP synthesis coupled electron transport
C3E78_RS15540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C3E78_RS15545	COG0713	ATP synthesis coupled electron transport
C3E78_RS15555	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3E78_RS15560	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C3E78_RS15565	COG1034	ATP synthesis coupled electron transport
C3E78_RS15570	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C3E78_RS15580	COG0649	NAD binding
C3E78_RS15585	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3E78_RS15590	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3E78_RS15600	COG2226	methyltransferase
C3E78_RS15605	COG1169	isochorismate synthase
C3E78_RS15620	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C3E78_RS15620	COG1672	PFAM Archaeal ATPase
C3E78_RS15635	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C3E78_RS15640	COG4948	Mandelate Racemase Muconate Lactonizing
C3E78_RS15645	COG0702	epimerase
C3E78_RS15695	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C3E78_RS15705	COG1131	(ABC) transporter
C3E78_RS15720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C3E78_RS15730	COG0785	Cytochrome C biogenesis protein
C3E78_RS15740	COG0406	alpha-ribazole phosphatase activity
C3E78_RS15745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C3E78_RS15755	COG0113	porphobilinogen synthase activity
C3E78_RS15770	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C3E78_RS15775	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C3E78_RS15795	COG1595	DNA-templated transcription, initiation
C3E78_RS15825	COG0123	including yeast histone deacetylase and acetoin utilization protein
C3E78_RS15840	COG1280	lysine exporter protein (LysE YggA)
C3E78_RS15845	COG1082	Xylose isomerase domain protein TIM barrel
C3E78_RS15850	COG0248	Ppx GppA phosphatase
C3E78_RS15875	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C3E78_RS15880	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C3E78_RS15890	COG1194	a g-specific adenine glycosylase
C3E78_RS15900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C3E78_RS15900	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C3E78_RS15905	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C3E78_RS15910	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C3E78_RS15915	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C3E78_RS15920	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C3E78_RS15930	COG1216	Glycosyl transferase, family 2
C3E78_RS15930	COG1442	glycosyl transferase family 8
C3E78_RS15945	COG0649	NAD binding
C3E78_RS15965	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C3E78_RS15980	COG0302	gtp cyclohydrolase
C3E78_RS15995	COG0037	tRNA processing
C3E78_RS16005	COG2027	D-alanyl-D-alanine carboxypeptidase
C3E78_RS16010	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C3E78_RS16020	COG2133	pyrroloquinoline quinone binding
C3E78_RS16085	COG1674	ftsk spoiiie
C3E78_RS16105	COG1404	Belongs to the peptidase S8 family
C3E78_RS16130	COG1404	Belongs to the peptidase S8 family
C3E78_RS16155	COG0667	Aldo Keto reductase
C3E78_RS16160	COG0789	Transcriptional regulator
C3E78_RS16165	COG0463	Glycosyl transferase, family 2
C3E78_RS16175	COG0477	Major facilitator Superfamily
C3E78_RS16190	COG0531	amino acid
C3E78_RS16215	COG2130	NADP-dependent
C3E78_RS16235	COG1764	response to oxidative stress
C3E78_RS16270	COG1797	cobyrinic acid a,c-diamide synthase activity
C3E78_RS16275	COG1587	Uroporphyrinogen-III synthase
C3E78_RS16275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C3E78_RS16280	COG0406	alpha-ribazole phosphatase activity
C3E78_RS16295	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C3E78_RS16310	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C3E78_RS16320	COG1492	cobalamin metabolic process
C3E78_RS16330	COG1278	Cold shock
C3E78_RS16340	COG3845	ABC transporter
C3E78_RS16380	COG1846	Transcriptional regulator
C3E78_RS16385	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C3E78_RS16385	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C3E78_RS16385	COG1703	isobutyryl-CoA mutase activity
C3E78_RS16390	COG2160	L-arabinose isomerase activity
C3E78_RS16405	COG1609	Transcriptional regulator
C3E78_RS16410	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3E78_RS16415	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3E78_RS16425	COG1879	ABC-type sugar transport system periplasmic component
C3E78_RS16440	COG1024	Enoyl-CoA hydratase
C3E78_RS16445	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3E78_RS16455	COG0542	response to heat
C3E78_RS16460	COG0543	2 iron, 2 sulfur cluster binding
C3E78_RS16460	COG0633	Ferredoxin
C3E78_RS16510	COG1960	acyl-CoA dehydrogenase activity
C3E78_RS16520	COG1012	belongs to the aldehyde dehydrogenase family
C3E78_RS16525	COG1414	Transcriptional regulator
C3E78_RS16530	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C3E78_RS16535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3E78_RS16540	COG0318	PFAM AMP-dependent synthetase and ligase
C3E78_RS16545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C3E78_RS16550	COG1024	Enoyl-CoA hydratase
C3E78_RS16570	COG1063	alcohol dehydrogenase
C3E78_RS16580	COG1073	alpha beta
C3E78_RS16595	COG0492	ferredoxin-NADP+ reductase activity
C3E78_RS16620	COG1012	belongs to the aldehyde dehydrogenase family
C3E78_RS16650	COG1414	Transcriptional regulator
C3E78_RS16655	COG1414	Transcriptional regulator
C3E78_RS16670	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3E78_RS16675	COG1129	ABC transporter
C3E78_RS16690	COG0604	alcohol dehydrogenase
C3E78_RS16695	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3E78_RS16700	COG1129	ABC transporter
C3E78_RS16705	COG1879	ABC-type sugar transport system periplasmic component
C3E78_RS16710	COG0154	amidase activity
C3E78_RS16715	COG3971	2-oxopent-4-enoate hydratase activity
C3E78_RS16740	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C3E78_RS16755	COG0531	amino acid
C3E78_RS16795	COG2050	protein possibly involved in aromatic compounds catabolism
C3E78_RS16800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C3E78_RS16805	COG2151	metal-sulfur cluster biosynthetic enzyme
C3E78_RS16810	COG3396	Phenylacetate-CoA oxygenase
C3E78_RS16815	COG3460	Phenylacetate-CoA oxygenase
C3E78_RS16820	COG3396	Phenylacetate-CoA oxygenase
C3E78_RS16850	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3E78_RS16890	COG0318	PFAM AMP-dependent synthetase and ligase
C3E78_RS16900	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C3E78_RS16920	COG0789	Transcriptional regulator
C3E78_RS16925	COG0484	heat shock protein binding
C3E78_RS16930	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C3E78_RS16935	COG0443	Heat shock 70 kDa protein
C3E78_RS16950	COG2409	Drug exporters of the RND superfamily
C3E78_RS16955	COG1309	transcriptional regulator
C3E78_RS16975	COG1054	Belongs to the UPF0176 family
C3E78_RS16985	COG0154	amidase activity
C3E78_RS17020	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS17040	COG1122	ATPase activity
C3E78_RS17045	COG4721	ABC-type cobalt transport system, permease component
C3E78_RS17050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3E78_RS17070	COG2271	Major facilitator Superfamily
C3E78_RS17075	COG2181	nitrate reductase activity
C3E78_RS17075	COG0247	lactate metabolic process
C3E78_RS17080	COG3012	SEC-C Motif Domain Protein
C3E78_RS17090	COG1131	(ABC) transporter
C3E78_RS17095	COG2942	2-epimerase
C3E78_RS17100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3E78_RS17110	COG2313	pseudouridylate synthase activity
C3E78_RS17120	COG0717	Belongs to the dCTP deaminase family
C3E78_RS17130	COG0454	-acetyltransferase
C3E78_RS17165	COG0745	RESPONSE REGULATOR receiver
C3E78_RS17175	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C3E78_RS17185	COG0667	Aldo Keto reductase
C3E78_RS17205	COG1739	Uncharacterized protein family UPF0029
C3E78_RS17220	COG1960	acyl-CoA dehydrogenase activity
C3E78_RS17240	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3E78_RS17245	COG0022	dehydrogenase e1 component
C3E78_RS17255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3E78_RS17260	COG0697	spore germination
C3E78_RS17265	COG1950	PFAM Membrane protein of
C3E78_RS17270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C3E78_RS17280	COG0745	RESPONSE REGULATOR receiver
C3E78_RS17285	COG2205	protein histidine kinase activity
C3E78_RS17290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3E78_RS17295	COG0697	spore germination
C3E78_RS17310	COG1053	succinate dehydrogenase
C3E78_RS17315	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS17320	COG1028	Short-chain dehydrogenase reductase Sdr
C3E78_RS17325	COG1902	pentaerythritol trinitrate reductase activity
C3E78_RS17335	COG1012	belongs to the aldehyde dehydrogenase family
C3E78_RS17350	COG1129	ABC transporter
C3E78_RS17375	COG1335	isochorismatase
C3E78_RS17395	COG1794	racemase activity, acting on amino acids and derivatives
C3E78_RS17410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3E78_RS17440	COG1126	abc transporter atp-binding protein
C3E78_RS17445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3E78_RS17450	COG1024	Enoyl-CoA hydratase
C3E78_RS17465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3E78_RS17470	COG1960	acyl-CoA dehydrogenase activity
C3E78_RS17505	COG0657	acetylesterase activity
C3E78_RS17540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C3E78_RS17560	COG0300	oxidoreductase activity
C3E78_RS17600	COG1024	Enoyl-CoA hydratase
C3E78_RS17620	COG0702	epimerase
C3E78_RS17630	COG0531	amino acid
C3E78_RS17635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3E78_RS17650	COG0300	oxidoreductase activity
C3E78_RS17660	COG1120	ATPase activity
C3E78_RS17665	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3E78_RS17670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3E78_RS17675	COG1024	Enoyl-CoA hydratase
C3E78_RS17675	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3E78_RS17680	COG0183	Belongs to the thiolase family
C3E78_RS17695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C3E78_RS17720	COG0765	amino acid transport
C3E78_RS17725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3E78_RS17735	COG1695	Transcriptional regulator
C3E78_RS17750	COG1902	pentaerythritol trinitrate reductase activity
C3E78_RS17750	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3E78_RS17770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C3E78_RS17780	COG1937	Protein conserved in bacteria
C3E78_RS17810	COG1132	(ABC) transporter
C3E78_RS17830	COG0586	Pfam SNARE associated Golgi protein
C3E78_RS17840	COG0305	Participates in initiation and elongation during chromosome replication
C3E78_RS17845	COG0534	Mate efflux family protein
C3E78_RS17855	COG0747	negative chemotaxis
C3E78_RS17860	COG0359	binds to the 23S rRNA
C3E78_RS17865	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C3E78_RS17875	COG0360	Binds together with S18 to 16S ribosomal RNA
C3E78_RS17890	COG1643	Atp-dependent helicase
C3E78_RS17895	COG0667	Aldo Keto reductase
C3E78_RS17905	COG1305	Transglutaminase-like
C3E78_RS17940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3E78_RS17950	COG1260	myo-inositol-1-phosphate synthase
C3E78_RS17965	COG0411	ABC transporter
C3E78_RS17980	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3E78_RS17990	COG0617	tRNA 3'-terminal CCA addition
C3E78_RS18010	COG2815	serine threonine protein kinase
C3E78_RS18010	COG0515	serine threonine protein kinase
C3E78_RS18015	COG0492	ferredoxin-NADP+ reductase activity
C3E78_RS18020	COG3118	belongs to the thioredoxin family
C3E78_RS18030	COG1192	Involved in chromosome partitioning
C3E78_RS18035	COG0357	Ribosomal RNA small subunit methyltransferase G
C3E78_RS18045	COG0706	membrane insertase activity
C3E78_RS18050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C3E78_RS18055	COG0594	ribonuclease P activity