locus-tag	class	description
C6I20_RS00125	COG1902	pentaerythritol trinitrate reductase activity
C6I20_RS00150	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_RS00250	COG0542	response to heat
C6I20_RS00260	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6I20_RS00275	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6I20_RS00275	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6I20_RS00275	COG1703	isobutyryl-CoA mutase activity
C6I20_RS00305	COG3845	ABC transporter
C6I20_RS00320	COG1492	cobalamin metabolic process
C6I20_RS00330	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C6I20_RS00340	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C6I20_RS00345	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C6I20_RS00360	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
C6I20_RS00365	COG0310	cobalt ion transport
C6I20_RS00380	COG1797	cobyrinic acid a,c-diamide synthase activity
C6I20_RS00385	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C6I20_RS00490	COG2130	NADP-dependent
C6I20_RS00495	COG1643	Atp-dependent helicase
C6I20_RS00505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6I20_RS00510	COG1136	(ABC) transporter
C6I20_RS00515	COG0577	efflux transmembrane transporter activity
C6I20_RS00515	COG1136	(ABC) transporter
C6I20_RS00530	COG0789	Transcriptional regulator
C6I20_RS00535	COG0667	Aldo Keto reductase
C6I20_RS00565	COG2072	flavoprotein involved in K transport
C6I20_RS00575	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C6I20_RS00590	COG0037	tRNA processing
C6I20_RS00605	COG0302	gtp cyclohydrolase
C6I20_RS00610	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C6I20_RS00620	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C6I20_RS00640	COG0649	NAD binding
C6I20_RS00650	COG0463	Glycosyl transferase, family 2
C6I20_RS00660	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C6I20_RS00665	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C6I20_RS00670	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C6I20_RS00675	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C6I20_RS00710	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C6I20_RS00715	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C6I20_RS00735	COG0248	Ppx GppA phosphatase
C6I20_RS00740	COG1082	Xylose isomerase domain protein TIM barrel
C6I20_RS00745	COG1280	lysine exporter protein (LysE YggA)
C6I20_RS00760	COG0123	including yeast histone deacetylase and acetoin utilization protein
C6I20_RS00790	COG1595	DNA-templated transcription, initiation
C6I20_RS00800	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_RS00810	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C6I20_RS00815	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C6I20_RS00820	COG0181	hydroxymethylbilane synthase activity
C6I20_RS00830	COG0113	porphobilinogen synthase activity
C6I20_RS00840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C6I20_RS00845	COG0406	alpha-ribazole phosphatase activity
C6I20_RS00855	COG0785	Cytochrome C biogenesis protein
C6I20_RS00865	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C6I20_RS00870	COG1131	(ABC) transporter
C6I20_RS00890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C6I20_RS00920	COG4948	Mandelate Racemase Muconate Lactonizing
C6I20_RS00925	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C6I20_RS00945	COG1169	isochorismate synthase
C6I20_RS00950	COG2226	methyltransferase
C6I20_RS00955	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C6I20_RS00965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6I20_RS00970	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6I20_RS00975	COG0649	NAD binding
C6I20_RS00985	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C6I20_RS00990	COG1034	ATP synthesis coupled electron transport
C6I20_RS00995	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C6I20_RS01000	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6I20_RS01010	COG0713	ATP synthesis coupled electron transport
C6I20_RS01015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C6I20_RS01025	COG1007	ATP synthesis coupled electron transport
C6I20_RS01030	COG0142	geranyltranstransferase activity
C6I20_RS01045	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6I20_RS01050	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6I20_RS01055	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6I20_RS01065	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6I20_RS01070	COG0839	Belongs to the complex I subunit 6 family
C6I20_RS01075	COG0713	ATP synthesis coupled electron transport
C6I20_RS01090	COG1007	ATP synthesis coupled electron transport
C6I20_RS01095	COG1666	GTP binding
C6I20_RS01105	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C6I20_RS01130	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C6I20_RS01165	COG3177	Filamentation induced by cAMP protein fic
C6I20_RS01170	COG1012	belongs to the aldehyde dehydrogenase family
C6I20_RS01180	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C6I20_RS01185	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C6I20_RS01190	COG1942	4-Oxalocrotonate Tautomerase
C6I20_RS01195	COG2197	response regulator
C6I20_RS01210	COG0167	dihydroorotate dehydrogenase activity
C6I20_RS01225	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C6I20_RS01230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C6I20_RS01250	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C6I20_RS01265	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C6I20_RS01275	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C6I20_RS01280	COG0081	regulation of translation
C6I20_RS01300	COG0222	ribosome binding
C6I20_RS01310	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C6I20_RS01315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C6I20_RS01360	COG0085	RNA polymerase activity
C6I20_RS01365	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C6I20_RS01375	COG3594	Acyltransferase
C6I20_RS01380	COG1051	belongs to the nudix hydrolase family
C6I20_RS01400	COG0277	FAD linked oxidase domain protein
C6I20_RS01400	COG0247	lactate metabolic process
C6I20_RS01410	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C6I20_RS01415	COG0049	tRNA binding
C6I20_RS01420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C6I20_RS01425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C6I20_RS01475	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C6I20_RS01480	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C6I20_RS01495	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C6I20_RS01500	COG0088	Forms part of the polypeptide exit tunnel
C6I20_RS01505	COG0089	rRNA binding
C6I20_RS01510	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C6I20_RS01515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C6I20_RS01520	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C6I20_RS01525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C6I20_RS01530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C6I20_RS01535	COG0255	Belongs to the universal ribosomal protein uL29 family
C6I20_RS01540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C6I20_RS01545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C6I20_RS01550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C6I20_RS01555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C6I20_RS01560	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C6I20_RS01565	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C6I20_RS01570	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C6I20_RS01575	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C6I20_RS01580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C6I20_RS01585	COG1841	ribosomal large subunit assembly
C6I20_RS01590	COG0200	Binds to the 23S rRNA
C6I20_RS01600	COG0563	adenylate kinase activity
C6I20_RS01615	COG1834	amidinotransferase
C6I20_RS01620	COG1522	sequence-specific DNA binding
C6I20_RS01630	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C6I20_RS01635	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C6I20_RS01640	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C6I20_RS01645	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C6I20_RS01650	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C6I20_RS01655	COG0202	RNA polymerase activity
C6I20_RS01660	COG0203	ribosomal protein L17
C6I20_RS01670	COG0101	tRNA pseudouridine synthase activity
C6I20_RS01675	COG0372	Belongs to the citrate synthase family
C6I20_RS01680	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C6I20_RS01685	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C6I20_RS01690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6I20_RS01700	COG0456	acetyltransferase
C6I20_RS01705	COG1072	(Pantothenic acid kinase))
C6I20_RS01710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C6I20_RS01715	COG0736	holo-[acyl-carrier-protein] synthase activity
C6I20_RS01720	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C6I20_RS01720	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C6I20_RS01725	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C6I20_RS01735	COG0802	atpase or kinase
C6I20_RS01740	COG0456	acetyltransferase
C6I20_RS01740	COG1214	PFAM Peptidase M22, glycoprotease
C6I20_RS01765	COG2318	DinB family
C6I20_RS01770	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C6I20_RS01790	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C6I20_RS01800	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C6I20_RS01805	COG0459	protein refolding
C6I20_RS01810	COG0557	exoribonuclease II activity
C6I20_RS01830	COG0516	GMP reductase activity
C6I20_RS01850	COG2837	iron assimilation
C6I20_RS01860	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C6I20_RS01860	COG0519	Catalyzes the synthesis of GMP from XMP
C6I20_RS01875	COG0723	plastoquinol--plastocyanin reductase activity
C6I20_RS01875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6I20_RS01890	COG0405	Gamma-glutamyltransferase
C6I20_RS01895	COG0584	glycerophosphoryl diester phosphodiesterase
C6I20_RS01920	COG2197	response regulator
C6I20_RS01925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C6I20_RS01930	COG1725	Transcriptional regulator
C6I20_RS01965	COG0596	Alpha beta hydrolase
C6I20_RS01970	COG0045	succinate-CoA ligase (ADP-forming) activity
C6I20_RS01995	COG0138	bifunctional purine biosynthesis protein purh
C6I20_RS02005	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C6I20_RS02015	COG0039	L-malate dehydrogenase activity
C6I20_RS02035	COG2838	Isocitrate dehydrogenase
C6I20_RS02045	COG2814	Major facilitator Superfamily
C6I20_RS02050	COG3842	ATPase activity
C6I20_RS02055	COG4208	sulfate ABC transporter
C6I20_RS02095	COG0077	Prephenate dehydratase
C6I20_RS02095	COG1605	Chorismate mutase
C6I20_RS02100	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C6I20_RS02105	COG0180	Tryptophanyl-tRNA synthetase
C6I20_RS02125	COG1053	succinate dehydrogenase
C6I20_RS02130	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C6I20_RS02150	COG1473	amidohydrolase
C6I20_RS02150	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C6I20_RS02155	COG1744	ABC transporter substrate-binding protein PnrA-like
C6I20_RS02160	COG3845	ABC transporter
C6I20_RS02165	COG4603	Belongs to the binding-protein-dependent transport system permease family
C6I20_RS02170	COG1079	Belongs to the binding-protein-dependent transport system permease family
C6I20_RS02180	COG2124	cytochrome p450
C6I20_RS02195	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C6I20_RS02205	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C6I20_RS02215	COG1012	belongs to the aldehyde dehydrogenase family
C6I20_RS02220	COG1012	belongs to the aldehyde dehydrogenase family
C6I20_RS02225	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C6I20_RS02230	COG0737	Belongs to the 5'-nucleotidase family
C6I20_RS02235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6I20_RS02265	COG2385	sporulation resulting in formation of a cellular spore
C6I20_RS02275	COG4770	biotin carboxylase activity
C6I20_RS02280	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS02290	COG0424	maF-like protein
C6I20_RS02305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6I20_RS02320	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C6I20_RS02330	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C6I20_RS02345	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS02350	COG0697	spore germination
C6I20_RS02355	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_RS02360	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS02370	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS02385	COG1125	glycine betaine transport
C6I20_RS02385	COG0517	IMP dehydrogenase activity
C6I20_RS02390	COG1174	glycine betaine transport
C6I20_RS02420	COG0183	Belongs to the thiolase family
C6I20_RS02425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C6I20_RS02430	COG1063	alcohol dehydrogenase
C6I20_RS02440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6I20_RS02445	COG1611	Belongs to the LOG family
C6I20_RS02450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C6I20_RS02455	COG2818	Glycosylase
C6I20_RS02465	COG1024	Enoyl-CoA hydratase
C6I20_RS02500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C6I20_RS02510	COG0488	(ABC) transporter
C6I20_RS02520	COG2239	Acts as a magnesium transporter
C6I20_RS02540	COG0657	acetylesterase activity
C6I20_RS02555	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS02565	COG2030	dehydratase
C6I20_RS02590	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C6I20_RS02600	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_RS02605	COG1192	Involved in chromosome partitioning
C6I20_RS02615	COG0513	Belongs to the DEAD box helicase family
C6I20_RS02640	COG1309	transcriptional regulator
C6I20_RS02660	COG0210	DNA helicase
C6I20_RS02680	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C6I20_RS02710	COG3480	Lon protease (S16) C-terminal proteolytic domain
C6I20_RS02720	COG1615	UPF0182 protein
C6I20_RS02735	COG1024	Enoyl-CoA hydratase
C6I20_RS02740	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS02765	COG0640	Transcriptional regulator
C6I20_RS02880	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS02885	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_RS02910	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS02945	COG4221	oxidoreductase activity
C6I20_RS02950	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C6I20_RS02955	COG1609	Transcriptional regulator
C6I20_RS02970	COG1609	Transcriptional regulator
C6I20_RS03000	COG1129	ABC transporter
C6I20_RS03005	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6I20_RS03010	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6I20_RS03020	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C6I20_RS03055	COG0535	radical SAM domain protein
C6I20_RS03080	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C6I20_RS03085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6I20_RS03095	COG2197	response regulator
C6I20_RS03100	COG4585	Histidine kinase
C6I20_RS03150	COG0702	epimerase
C6I20_RS03190	COG1309	transcriptional regulator
C6I20_RS03195	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS03200	COG0657	acetylesterase activity
C6I20_RS03215	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS03230	COG2030	dehydratase
C6I20_RS03235	COG1053	succinate dehydrogenase
C6I20_RS03240	COG3971	2-oxopent-4-enoate hydratase activity
C6I20_RS03245	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C6I20_RS03250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6I20_RS03265	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS03270	COG2267	carboxylic ester hydrolase activity
C6I20_RS03305	COG1115	amino acid carrier protein
C6I20_RS03310	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS03315	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS03320	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS03330	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_RS03335	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS03345	COG1309	transcriptional regulator
C6I20_RS03350	COG0183	Belongs to the thiolase family
C6I20_RS03390	COG1024	Enoyl-CoA hydratase
C6I20_RS03400	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_RS03405	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_RS03420	COG3321	synthase
C6I20_RS03420	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_RS03420	COG0604	alcohol dehydrogenase
C6I20_RS03425	COG1012	belongs to the aldehyde dehydrogenase family
C6I20_RS03430	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C6I20_RS03435	COG0183	Belongs to the thiolase family
C6I20_RS03440	COG2124	cytochrome p450
C6I20_RS03465	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_RS03470	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_RS03485	COG2070	2-Nitropropane dioxygenase
C6I20_RS03490	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_RS03495	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS03500	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS03515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6I20_RS03520	COG1053	succinate dehydrogenase
C6I20_RS03530	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C6I20_RS03580	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_RS03630	COG1024	Enoyl-CoA hydratase
C6I20_RS03635	COG2267	carboxylic ester hydrolase activity
C6I20_RS03650	COG2130	NADP-dependent
C6I20_RS03655	COG2814	Major facilitator Superfamily
C6I20_RS03660	COG0183	Belongs to the thiolase family
C6I20_RS03665	COG1024	Enoyl-CoA hydratase
C6I20_RS03670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6I20_RS03680	COG2508	Transcriptional regulator
C6I20_RS03705	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_RS03715	COG1288	antiporter activity
C6I20_RS03725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C6I20_RS03745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6I20_RS03775	COG0406	alpha-ribazole phosphatase activity
C6I20_RS03780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C6I20_RS03785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C6I20_RS03810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C6I20_RS03815	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C6I20_RS03845	COG2837	iron assimilation
C6I20_RS03880	COG2353	YceI-like domain
C6I20_RS03885	COG1309	transcriptional regulator
C6I20_RS03890	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS03895	COG0183	Belongs to the thiolase family
C6I20_RS03900	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_RS03910	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C6I20_RS03910	COG3321	synthase
C6I20_RS03910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6I20_RS03915	COG0736	holo-[acyl-carrier-protein] synthase activity
C6I20_RS03925	COG3173	Aminoglycoside phosphotransferase
C6I20_RS03935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6I20_RS03940	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C6I20_RS03950	COG2346	COG2346, Truncated hemoglobins
C6I20_RS03955	COG0668	transmembrane transport
C6I20_RS03975	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C6I20_RS03980	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C6I20_RS03985	COG0657	acetylesterase activity
C6I20_RS04030	COG1024	Enoyl-CoA hydratase
C6I20_RS04040	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_RS04085	COG0544	peptidyl-prolyl cis-trans isomerase activity
C6I20_RS04105	COG2188	Transcriptional regulator
C6I20_RS04110	COG1082	Xylose isomerase domain protein TIM barrel
C6I20_RS04115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6I20_RS04125	COG3718	enzyme involved in inositol metabolism
C6I20_RS04130	COG3962	Belongs to the TPP enzyme family
C6I20_RS04155	COG0673	inositol 2-dehydrogenase activity
C6I20_RS04160	COG0673	inositol 2-dehydrogenase activity
C6I20_RS04165	COG0673	inositol 2-dehydrogenase activity
C6I20_RS04175	COG0740	serine-type endopeptidase activity
C6I20_RS04180	COG0740	serine-type endopeptidase activity
C6I20_RS04185	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C6I20_RS04190	COG3268	Saccharopine dehydrogenase
C6I20_RS04195	COG1271	oxidase subunit
C6I20_RS04205	COG1105	Belongs to the carbohydrate kinase PfkB family
C6I20_RS04210	COG1349	DNA-binding transcription factor activity
C6I20_RS04215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6I20_RS04220	COG1063	alcohol dehydrogenase
C6I20_RS04225	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6I20_RS04240	COG0525	valine-tRNA ligase activity
C6I20_RS04245	COG2409	Drug exporters of the RND superfamily
C6I20_RS04250	COG0285	dihydrofolate synthase activity
C6I20_RS04260	COG0105	UTP biosynthetic process
C6I20_RS04275	COG2807	transmembrane transport
C6I20_RS04285	COG1530	ribonuclease E activity
C6I20_RS04290	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C6I20_RS04295	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C6I20_RS04300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C6I20_RS04305	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C6I20_RS04310	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C6I20_RS04315	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C6I20_RS04325	COG0406	alpha-ribazole phosphatase activity
C6I20_RS04360	COG0477	Major facilitator Superfamily
C6I20_RS04365	COG3590	peptidase
C6I20_RS04395	COG1216	Glycosyl transferase, family 2
C6I20_RS04440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C6I20_RS04445	COG0569	domain protein
C6I20_RS04450	COG0495	leucyl-tRNA aminoacylation
C6I20_RS04455	COG1307	EDD domain protein, DegV family
C6I20_RS04460	COG1555	photosystem II stabilization
C6I20_RS04460	COG1596	polysaccharide export
C6I20_RS04480	COG0268	Binds directly to 16S ribosomal RNA
C6I20_RS04485	COG0481	GTPase activity
C6I20_RS04495	COG2258	MOSC domain
C6I20_RS04510	COG1022	Amp-dependent synthetase and ligase
C6I20_RS04530	COG1420	regulation of RNA biosynthetic process
C6I20_RS04535	COG0484	heat shock protein binding
C6I20_RS04540	COG0537	adenosine 5'-monophosphoramidase activity
C6I20_RS04550	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C6I20_RS04565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C6I20_RS04575	COG1254	Belongs to the acylphosphatase family
C6I20_RS04585	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C6I20_RS04585	COG1796	DNA polymerase
C6I20_RS04600	COG0714	Associated with various cellular activities
C6I20_RS04620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6I20_RS04630	COG1012	belongs to the aldehyde dehydrogenase family
C6I20_RS04640	COG1381	Involved in DNA repair and RecF pathway recombination
C6I20_RS04645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C6I20_RS04655	COG0179	Fumarylacetoacetate (FAA) hydrolase
C6I20_RS04660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6I20_RS04715	COG1414	Transcriptional regulator
C6I20_RS04720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C6I20_RS04725	COG0066	3-isopropylmalate dehydratase activity
C6I20_RS04740	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C6I20_RS04745	COG0626	cystathionine gamma-synthase activity
C6I20_RS04750	COG1181	Belongs to the D-alanine--D-alanine ligase family
C6I20_RS04775	COG0154	amidase activity
C6I20_RS04780	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C6I20_RS04785	COG1461	Dihydroxyacetone kinase
C6I20_RS04795	COG0742	ribosomal rna small subunit methyltransferase
C6I20_RS04800	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C6I20_RS04805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C6I20_RS04815	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C6I20_RS04820	COG0571	ribonuclease III activity
C6I20_RS04825	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C6I20_RS04830	COG0456	acetyltransferase
C6I20_RS04835	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C6I20_RS04865	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C6I20_RS04915	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C6I20_RS04970	COG1937	Protein conserved in bacteria
C6I20_RS04980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C6I20_RS04980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6I20_RS04990	COG2409	Drug exporters of the RND superfamily
C6I20_RS04995	COG2890	protein-(glutamine-N5) methyltransferase activity
C6I20_RS05000	COG0514	ATP-dependent DNA helicase (RecQ)
C6I20_RS05010	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_RS05025	COG3022	response to hydroperoxide
C6I20_RS05030	COG2119	membrane
C6I20_RS05070	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C6I20_RS05085	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C6I20_RS05085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C6I20_RS05095	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C6I20_RS05105	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6I20_RS05135	COG1309	transcriptional regulator
C6I20_RS05190	COG1937	Protein conserved in bacteria
C6I20_RS05195	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C6I20_RS05200	COG0596	Alpha beta hydrolase
C6I20_RS05205	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C6I20_RS05210	COG1216	Glycosyl transferase, family 2
C6I20_RS05215	COG0745	RESPONSE REGULATOR receiver
C6I20_RS05220	COG2205	protein histidine kinase activity
C6I20_RS05235	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C6I20_RS05240	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C6I20_RS05240	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C6I20_RS05275	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS05280	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS05320	COG1063	alcohol dehydrogenase
C6I20_RS05335	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
C6I20_RS05355	COG0174	glutamine synthetase
C6I20_RS05370	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C6I20_RS05390	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6I20_RS05395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6I20_RS05410	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C6I20_RS05415	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C6I20_RS05435	COG0501	Belongs to the peptidase M48B family
C6I20_RS05445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6I20_RS05460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6I20_RS05465	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C6I20_RS05470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C6I20_RS05485	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C6I20_RS05490	COG0723	plastoquinol--plastocyanin reductase activity
C6I20_RS05495	COG2010	Cytochrome c
C6I20_RS05500	COG1845	cytochrome c oxidase, subunit III
C6I20_RS05510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C6I20_RS05540	COG1022	Amp-dependent synthetase and ligase
C6I20_RS05555	COG1940	carbohydrate kinase activity
C6I20_RS05560	COG1940	carbohydrate kinase activity
C6I20_RS05580	COG0205	6-phosphofructokinase activity
C6I20_RS05590	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C6I20_RS05610	COG2815	serine threonine protein kinase
C6I20_RS05610	COG0515	serine threonine protein kinase
C6I20_RS05620	COG2732	(Barnase) inhibitor
C6I20_RS05625	COG0142	geranyltranstransferase activity
C6I20_RS05650	COG2001	Belongs to the MraZ family
C6I20_RS05655	COG0275	rRNA processing
C6I20_RS05665	COG0768	penicillin binding
C6I20_RS05670	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C6I20_RS05675	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C6I20_RS05680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C6I20_RS05685	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C6I20_RS05695	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C6I20_RS05700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C6I20_RS05715	COG1496	oxidoreductase activity
C6I20_RS05720	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C6I20_RS05725	COG1799	cell septum assembly
C6I20_RS05740	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C6I20_RS05750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C6I20_RS05780	COG0587	DNA-directed DNA polymerase activity
C6I20_RS05790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C6I20_RS05795	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C6I20_RS05800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C6I20_RS05805	COG0131	Imidazoleglycerol-phosphate dehydratase
C6I20_RS05810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C6I20_RS05815	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C6I20_RS05820	COG0107	imidazoleglycerol-phosphate synthase activity
C6I20_RS05825	COG1132	(ABC) transporter
C6I20_RS05830	COG1132	(ABC) transporter
C6I20_RS05835	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C6I20_RS05870	COG0134	indole-3-glycerol-phosphate synthase activity
C6I20_RS05875	COG0133	tryptophan synthase activity
C6I20_RS05880	COG0159	tryptophan synthase activity
C6I20_RS05885	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C6I20_RS05895	COG0069	glutamate synthase activity
C6I20_RS05895	COG0070	glutamate synthase
C6I20_RS05895	COG0067	glutamate synthase
C6I20_RS05905	COG0469	pyruvate kinase activity
C6I20_RS05925	COG0410	ABC transporter
C6I20_RS05940	COG0559	Belongs to the binding-protein-dependent transport system permease family
C6I20_RS05945	COG1811	Na channel or pump
C6I20_RS05970	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_RS05975	COG0277	FAD linked oxidase domain protein
C6I20_RS05980	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C6I20_RS05985	COG0438	transferase activity, transferring glycosyl groups
C6I20_RS05995	COG4981	capsule polysaccharide biosynthetic process
C6I20_RS06015	COG1362	aminopeptidase activity
C6I20_RS06020	COG0539	negative regulation of cytoplasmic translation
C6I20_RS06040	COG0237	dephospho-CoA kinase activity
C6I20_RS06045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C6I20_RS06055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C6I20_RS06070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C6I20_RS06095	COG0477	Major facilitator Superfamily
C6I20_RS06105	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C6I20_RS06130	COG1435	thymidine kinase activity
C6I20_RS06140	COG2860	membrane
C6I20_RS06145	COG1012	belongs to the aldehyde dehydrogenase family
C6I20_RS06155	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C6I20_RS06180	COG0756	dUTP diphosphatase activity
C6I20_RS06205	COG0569	domain protein
C6I20_RS06210	COG0531	amino acid
C6I20_RS06215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C6I20_RS06230	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C6I20_RS06235	COG4213	ABC transporter substrate-binding protein
C6I20_RS06245	COG4214	carbohydrate transport
C6I20_RS06250	COG1940	carbohydrate kinase activity
C6I20_RS06255	COG1940	carbohydrate kinase activity
C6I20_RS06265	COG1070	Carbohydrate kinase
C6I20_RS06275	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C6I20_RS06285	COG1946	Acyl-CoA thioesterase
C6I20_RS06295	COG2030	dehydratase
C6I20_RS06305	COG0183	Belongs to the thiolase family
C6I20_RS06325	COG0556	nucleotide-excision repair
C6I20_RS06340	COG0531	amino acid
C6I20_RS06345	COG2124	cytochrome p450
C6I20_RS06360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C6I20_RS06365	COG0322	excinuclease ABC activity
C6I20_RS06370	COG1660	Displays ATPase and GTPase activities
C6I20_RS06380	COG1481	regulation of sporulation
C6I20_RS06385	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C6I20_RS06390	COG0126	phosphoglycerate kinase activity
C6I20_RS06395	COG0149	triose-phosphate isomerase activity
C6I20_RS06400	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C6I20_RS06425	COG0166	Belongs to the GPI family
C6I20_RS06430	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C6I20_RS06440	COG0109	protoheme IX farnesyltransferase activity
C6I20_RS06465	COG1612	heme a metabolic process
C6I20_RS06480	COG1793	dna ligase
C6I20_RS06485	COG2357	RelA SpoT domain protein
C6I20_RS06520	COG0396	ATPase activity
C6I20_RS06525	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C6I20_RS06530	COG0822	iron-sulfur transferase activity
C6I20_RS06535	COG2151	metal-sulfur cluster biosynthetic enzyme
C6I20_RS06540	COG0488	(ABC) transporter
C6I20_RS06565	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C6I20_RS06580	COG3360	Dodecin
C6I20_RS06590	COG3830	Belongs to the UPF0237 family
C6I20_RS06590	COG0560	Phosphoserine phosphatase
C6I20_RS06595	COG1119	ATPase activity
C6I20_RS06615	COG1881	PFAM PEBP family protein
C6I20_RS06630	COG0242	peptide deformylase activity
C6I20_RS06635	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS06640	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS06660	COG0545	Peptidyl-prolyl cis-trans isomerase
C6I20_RS06665	COG1643	Atp-dependent helicase
C6I20_RS06675	COG2733	membrane
C6I20_RS06770	COG0328	RNA-DNA hybrid ribonuclease activity
C6I20_RS06780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6I20_RS06790	COG2208	phosphoserine phosphatase activity
C6I20_RS06795	COG0596	Alpha beta hydrolase
C6I20_RS06825	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C6I20_RS06835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6I20_RS06845	COG0667	Aldo Keto reductase
C6I20_RS06850	COG1968	undecaprenyl-diphosphatase activity
C6I20_RS06855	COG0598	Magnesium transport protein CorA
C6I20_RS06860	COG0215	cysteine-tRNA ligase activity
C6I20_RS06880	COG0646	methionine synthase
C6I20_RS06880	COG1410	methionine synthase
C6I20_RS06885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C6I20_RS06905	COG1222	aaa ATPase
C6I20_RS06915	COG4122	O-methyltransferase activity
C6I20_RS06925	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C6I20_RS06930	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C6I20_RS06935	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C6I20_RS06960	COG0805	protein transport
C6I20_RS06965	COG1597	lipid kinase activity
C6I20_RS06975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C6I20_RS06995	COG0463	Glycosyl transferase, family 2
C6I20_RS07005	COG0477	Major facilitator Superfamily
C6I20_RS07020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C6I20_RS07025	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C6I20_RS07060	COG2226	methyltransferase
C6I20_RS07090	COG0009	L-threonylcarbamoyladenylate synthase
C6I20_RS07095	COG0175	sulfate reduction
C6I20_RS07110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C6I20_RS07110	COG1648	precorrin-2 dehydrogenase activity
C6I20_RS07140	COG1595	DNA-templated transcription, initiation
C6I20_RS07155	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C6I20_RS07155	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C6I20_RS07180	COG0509	glycine decarboxylation via glycine cleavage system
C6I20_RS07205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C6I20_RS07230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C6I20_RS07245	COG2501	S4 domain
C6I20_RS07255	COG1051	belongs to the nudix hydrolase family
C6I20_RS07290	COG2066	Belongs to the glutaminase family
C6I20_RS07300	COG0659	secondary active sulfate transmembrane transporter activity
C6I20_RS07305	COG0475	glutathione-regulated potassium exporter activity
C6I20_RS07315	COG1131	(ABC) transporter
C6I20_RS07330	COG0668	transmembrane transport
C6I20_RS07375	COG2197	response regulator
C6I20_RS07390	COG1136	(ABC) transporter
C6I20_RS07395	COG1595	DNA-templated transcription, initiation
C6I20_RS07415	COG1309	transcriptional regulator
C6I20_RS07420	COG2409	Drug exporters of the RND superfamily
C6I20_RS07425	COG0662	Cupin 2, conserved barrel domain protein
C6I20_RS07450	COG1140	nitrate reductase beta subunit
C6I20_RS07465	COG0450	alkyl hydroperoxide reductase
C6I20_RS07470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C6I20_RS07475	COG2188	Transcriptional regulator
C6I20_RS07480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C6I20_RS07485	COG0730	response to heat
C6I20_RS07500	COG0745	RESPONSE REGULATOR receiver
C6I20_RS07505	COG2205	protein histidine kinase activity
C6I20_RS07510	COG2132	Multicopper oxidase
C6I20_RS07540	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_RS07555	COG1063	alcohol dehydrogenase
C6I20_RS07565	COG0515	serine threonine protein kinase
C6I20_RS07565	COG2815	serine threonine protein kinase
C6I20_RS07580	COG0798	PFAM Bile acid sodium symporter
C6I20_RS07585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6I20_RS07600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6I20_RS07635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6I20_RS07660	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
C6I20_RS07700	COG1160	GTP binding
C6I20_RS07705	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C6I20_RS07735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C6I20_RS07840	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
C6I20_RS07875	COG2197	response regulator
C6I20_RS07885	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS07895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6I20_RS07895	COG0574	Belongs to the PEP-utilizing enzyme family
C6I20_RS07900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6I20_RS07905	COG1074	ATP-dependent DNA helicase activity
C6I20_RS07910	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C6I20_RS07940	COG1396	sequence-specific DNA binding
C6I20_RS07965	COG1469	GTP cyclohydrolase I activity
C6I20_RS07970	COG0720	synthase
C6I20_RS07975	COG0602	queuosine metabolic process
C6I20_RS08035	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6I20_RS08045	COG2205	protein histidine kinase activity
C6I20_RS08070	COG0515	serine threonine protein kinase
C6I20_RS08070	COG2815	serine threonine protein kinase
C6I20_RS08085	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
C6I20_RS08105	COG0604	alcohol dehydrogenase
C6I20_RS08115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C6I20_RS08120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6I20_RS08125	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C6I20_RS08135	COG2261	transglycosylase associated protein
C6I20_RS08140	COG0783	Belongs to the Dps family
C6I20_RS08150	COG4941	Belongs to the sigma-70 factor family
C6I20_RS08170	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C6I20_RS08170	COG0519	Catalyzes the synthesis of GMP from XMP
C6I20_RS08200	COG1295	ribonuclease BN
C6I20_RS08215	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C6I20_RS08230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C6I20_RS08235	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C6I20_RS08240	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C6I20_RS08265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C6I20_RS08305	COG1126	abc transporter atp-binding protein
C6I20_RS08310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6I20_RS08315	COG0765	amino acid transport
C6I20_RS08320	COG0765	amino acid transport
C6I20_RS08345	COG2137	regulation of response to DNA damage stimulus
C6I20_RS08350	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C6I20_RS08360	COG1396	sequence-specific DNA binding
C6I20_RS08365	COG1058	Belongs to the CinA family
C6I20_RS08365	COG1546	Belongs to the CinA family
C6I20_RS08370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C6I20_RS08380	COG1674	ftsk spoiiie
C6I20_RS08390	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C6I20_RS08395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6I20_RS08415	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C6I20_RS08440	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C6I20_RS08445	COG3844	kynureninase activity
C6I20_RS08455	COG1185	polyribonucleotide nucleotidyltransferase activity
C6I20_RS08465	COG2755	lipolytic protein G-D-S-L family
C6I20_RS08475	COG0196	riboflavin kinase activity
C6I20_RS08480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C6I20_RS08485	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C6I20_RS08490	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C6I20_RS08495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C6I20_RS08510	COG0779	Required for maturation of 30S ribosomal subunits
C6I20_RS08525	COG0442	prolyl-tRNA aminoacylation
C6I20_RS08535	COG0726	polysaccharide deacetylase
C6I20_RS08585	COG0302	gtp cyclohydrolase
C6I20_RS08600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C6I20_RS08605	COG0750	zinc metalloprotease
C6I20_RS08620	COG1131	(ABC) transporter
C6I20_RS08625	COG4585	Histidine kinase
C6I20_RS08630	COG2197	response regulator
C6I20_RS08645	COG1012	belongs to the aldehyde dehydrogenase family
C6I20_RS08650	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C6I20_RS08655	COG1177	transmembrane transport
C6I20_RS08660	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6I20_RS08665	COG3842	ATPase activity
C6I20_RS08675	COG1522	sequence-specific DNA binding
C6I20_RS08695	COG1160	GTP binding
C6I20_RS08705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C6I20_RS08720	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C6I20_RS08750	COG0504	CTP synthase activity
C6I20_RS08765	COG0497	DNA recombination
C6I20_RS08770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C6I20_RS08785	COG0647	UMP catabolic process
C6I20_RS08815	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C6I20_RS08820	COG0589	response to stress
C6I20_RS08830	COG2824	Alkylphosphonate utilization operon protein PhnA
C6I20_RS08835	COG2094	Belongs to the DNA glycosylase MPG family
C6I20_RS08840	COG0165	Argininosuccinate lyase
C6I20_RS08845	COG1438	arginine binding
C6I20_RS08850	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C6I20_RS08855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C6I20_RS08860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C6I20_RS08865	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C6I20_RS08870	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C6I20_RS08885	COG1704	LemA family
C6I20_RS08890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6I20_RS08890	COG0072	phenylalanine-tRNA ligase activity
C6I20_RS08895	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C6I20_RS08900	COG5002	protein histidine kinase activity
C6I20_RS08905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6I20_RS08910	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C6I20_RS08915	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C6I20_RS08920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C6I20_RS08940	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C6I20_RS08945	COG0140	phosphoribosyl-ATP diphosphatase activity
C6I20_RS08950	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C6I20_RS08955	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C6I20_RS08955	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C6I20_RS08970	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C6I20_RS08985	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C6I20_RS08995	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C6I20_RS09005	COG1758	RNA polymerase activity
C6I20_RS09010	COG0194	GDP metabolic process
C6I20_RS09025	COG0284	orotidine-5'-phosphate decarboxylase activity
C6I20_RS09030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C6I20_RS09035	COG0505	Belongs to the CarA family
C6I20_RS09040	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C6I20_RS09045	COG0540	Belongs to the ATCase OTCase family
C6I20_RS09050	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C6I20_RS09065	COG1125	glycine betaine transport
C6I20_RS09065	COG0517	IMP dehydrogenase activity
C6I20_RS09070	COG1174	glycine betaine transport
C6I20_RS09080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C6I20_RS09085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C6I20_RS09095	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C6I20_RS09100	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C6I20_RS09105	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C6I20_RS09120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C6I20_RS09130	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C6I20_RS09135	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C6I20_RS09155	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C6I20_RS09160	COG0124	histidyl-tRNA synthetase
C6I20_RS09170	COG1196	nuclear chromosome segregation
C6I20_RS09180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C6I20_RS09185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C6I20_RS09195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C6I20_RS09200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C6I20_RS09210	COG2255	four-way junction helicase activity
C6I20_RS09215	COG0632	four-way junction helicase activity
C6I20_RS09220	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C6I20_RS09225	COG0217	transcriptional regulatory protein
C6I20_RS09230	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C6I20_RS09265	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C6I20_RS09280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C6I20_RS09290	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C6I20_RS09295	COG2201	protein-glutamate methylesterase activity
C6I20_RS09345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C6I20_RS09380	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS09405	COG2326	polyphosphate kinase activity
C6I20_RS09415	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6I20_RS09420	COG3253	May function as heme-dependent peroxidase
C6I20_RS09430	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C6I20_RS09445	COG0672	)-iron permease
C6I20_RS09455	COG0667	Aldo Keto reductase
C6I20_RS09465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C6I20_RS09510	COG2249	NAD(P)H dehydrogenase (quinone) activity
C6I20_RS09530	COG0343	queuine tRNA-ribosyltransferase activity
C6I20_RS09540	COG0644	oxidoreductase
C6I20_RS09560	COG5001	Diguanylate cyclase
C6I20_RS09560	COG3300	MHYT domain
C6I20_RS09585	COG2133	pyrroloquinoline quinone binding
C6I20_RS09590	COG2815	serine threonine protein kinase
C6I20_RS09590	COG0515	serine threonine protein kinase
C6I20_RS09600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C6I20_RS09615	COG3384	dioxygenase
C6I20_RS09630	COG2610	gluconate transmembrane transporter activity
C6I20_RS09640	COG3265	gluconokinase activity
C6I20_RS09645	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6I20_RS09665	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C6I20_RS09680	COG2308	Evidence 4 Homologs of previously reported genes of
C6I20_RS09680	COG2307	Protein conserved in bacteria
C6I20_RS09690	COG0233	cytoplasmic translational termination
C6I20_RS09695	COG0528	UMP kinase activity
C6I20_RS09700	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C6I20_RS09705	COG0052	Belongs to the universal ribosomal protein uS2 family
C6I20_RS09710	COG1196	nuclear chromosome segregation
C6I20_RS09710	COG0741	lytic transglycosylase activity
C6I20_RS09710	COG0739	heme binding
C6I20_RS09720	COG0758	DNA mediated transformation
C6I20_RS09730	COG0792	nuclease activity
C6I20_RS09740	COG1396	sequence-specific DNA binding
C6I20_RS09740	COG1917	Cupin 2, conserved barrel domain protein
C6I20_RS09750	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C6I20_RS09755	COG0335	large ribosomal subunit rRNA binding
C6I20_RS09760	COG0336	Belongs to the RNA methyltransferase TrmD family
C6I20_RS09765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C6I20_RS09770	COG1837	Belongs to the UPF0109 family
C6I20_RS09775	COG0228	four-way junction DNA binding
C6I20_RS09800	COG1393	Belongs to the ArsC family
C6I20_RS09815	COG3265	gluconokinase activity
C6I20_RS09825	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C6I20_RS09870	COG2233	PERMEase
C6I20_RS09885	COG0423	glycine-tRNA ligase activity
C6I20_RS09895	COG1121	(ABC) transporter
C6I20_RS09900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6I20_RS09920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6I20_RS09930	COG1027	Aspartate ammonia-lyase
C6I20_RS09935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C6I20_RS09940	COG0473	3-isopropylmalate dehydrogenase activity
C6I20_RS09950	COG0531	amino acid
C6I20_RS09970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C6I20_RS09975	COG0440	acetolactate synthase activity
C6I20_RS09990	COG0129	dihydroxy-acid dehydratase activity
C6I20_RS10025	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6I20_RS10035	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6I20_RS10040	COG0154	amidase activity
C6I20_RS10045	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6I20_RS10050	COG0596	Alpha beta hydrolase
C6I20_RS10060	COG0564	pseudouridine synthase activity
C6I20_RS10075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C6I20_RS10085	COG0482	sulfurtransferase activity
C6I20_RS10100	COG1104	cysteine desulfurase activity
C6I20_RS10110	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C6I20_RS10115	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C6I20_RS10125	COG0587	DNA-directed DNA polymerase activity
C6I20_RS10145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6I20_RS10150	COG0601	transmembrane transport
C6I20_RS10160	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C6I20_RS10165	COG2086	electron transfer activity
C6I20_RS10200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C6I20_RS10205	COG3281	Trehalose synthase
C6I20_RS10210	COG0366	Alpha amylase catalytic
C6I20_RS10215	COG0366	Alpha amylase catalytic
C6I20_RS10235	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C6I20_RS10245	COG0667	Aldo Keto reductase
C6I20_RS10300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6I20_RS10310	COG1278	Cold shock
C6I20_RS10345	COG0183	Belongs to the thiolase family
C6I20_RS10350	COG0346	lactoylglutathione lyase activity
C6I20_RS10380	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6I20_RS10390	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C6I20_RS10400	COG1528	Iron-storage protein
C6I20_RS10410	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6I20_RS10410	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6I20_RS10430	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C6I20_RS10435	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C6I20_RS10440	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C6I20_RS10445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C6I20_RS10450	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C6I20_RS10455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C6I20_RS10460	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C6I20_RS10465	COG0356	it plays a direct role in the translocation of protons across the membrane
C6I20_RS10475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C6I20_RS10490	COG2890	protein-(glutamine-N5) methyltransferase activity
C6I20_RS10495	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C6I20_RS10500	COG0254	rRNA binding
C6I20_RS10505	COG0386	Belongs to the glutathione peroxidase family
C6I20_RS10515	COG0083	homoserine kinase activity
C6I20_RS10520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C6I20_RS10525	COG0460	homoserine dehydrogenase
C6I20_RS10535	COG0019	diaminopimelate decarboxylase activity
C6I20_RS10540	COG0018	arginyl-trna synthetase
C6I20_RS10555	COG1764	response to oxidative stress
C6I20_RS10565	COG0567	Dehydrogenase, E1 component
C6I20_RS10565	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6I20_RS10570	COG0604	alcohol dehydrogenase
C6I20_RS10610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C6I20_RS10615	COG3842	ATPase activity
C6I20_RS10640	COG1595	DNA-templated transcription, initiation
C6I20_RS10645	COG2135	peptidase activity
C6I20_RS10665	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C6I20_RS10675	COG0483	inositol monophosphate 1-phosphatase activity
C6I20_RS10680	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C6I20_RS10690	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C6I20_RS10715	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS10730	COG1902	pentaerythritol trinitrate reductase activity
C6I20_RS10735	COG1252	NADH dehydrogenase
C6I20_RS10770	COG2301	Belongs to the HpcH HpaI aldolase family
C6I20_RS10785	COG4129	membrane
C6I20_RS10825	COG3135	benzoate transporter
C6I20_RS10840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C6I20_RS10845	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C6I20_RS10850	COG1234	tRNA 3'-trailer cleavage
C6I20_RS10855	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C6I20_RS10860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C6I20_RS10885	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C6I20_RS10895	COG1335	isochorismatase
C6I20_RS10900	COG4552	Acetyltransferase involved in intracellular survival and related
C6I20_RS10915	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
C6I20_RS10920	COG0145	ligase activity
C6I20_RS10925	COG4647	ligase activity
C6I20_RS10930	COG0145	ligase activity
C6I20_RS10935	COG3284	Transcriptional regulator
C6I20_RS10945	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C6I20_RS10950	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C6I20_RS10955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6I20_RS10985	COG1678	Uncharacterized ACR, COG1678
C6I20_RS11000	COG1309	transcriptional regulator
C6I20_RS11005	COG1470	cell adhesion involved in biofilm formation
C6I20_RS11010	COG1201	RNA secondary structure unwinding
C6I20_RS11030	COG2154	pterin-4-alpha-carbinolamine dehydratase
C6I20_RS11035	COG2226	methyltransferase
C6I20_RS11055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C6I20_RS11065	COG2177	Part of the ABC transporter FtsEX involved in
C6I20_RS11070	COG2884	Cell division ATP-binding protein ftsE
C6I20_RS11075	COG0673	inositol 2-dehydrogenase activity
C6I20_RS11080	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C6I20_RS11115	COG0515	serine threonine protein kinase
C6I20_RS11115	COG2815	serine threonine protein kinase
C6I20_RS11125	COG0475	glutathione-regulated potassium exporter activity
C6I20_RS11130	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C6I20_RS11130	COG0515	serine threonine protein kinase
C6I20_RS11200	COG2318	DinB family
C6I20_RS11225	COG0745	RESPONSE REGULATOR receiver
C6I20_RS11230	COG2205	protein histidine kinase activity
C6I20_RS11235	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C6I20_RS11245	COG1842	Phage shock protein A
C6I20_RS11295	COG0653	protein targeting
C6I20_RS11300	COG3214	Protein conserved in bacteria
C6I20_RS11305	COG2197	response regulator
C6I20_RS11310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C6I20_RS11315	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C6I20_RS11320	COG5401	PFAM Sporulation and spore germination
C6I20_RS11325	COG5002	protein histidine kinase activity
C6I20_RS11325	COG5000	phosphorelay sensor kinase activity
C6I20_RS11330	COG0745	RESPONSE REGULATOR receiver
C6I20_RS11335	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C6I20_RS11355	COG2835	tetraacyldisaccharide 4'-kinase activity
C6I20_RS11390	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C6I20_RS11405	COG1134	teichoic acid transport
C6I20_RS11405	COG1388	LysM domain
C6I20_RS11410	COG1316	TRANSCRIPTIONal
C6I20_RS11420	COG1316	TRANSCRIPTIONal
C6I20_RS11425	COG2171	N-acyltransferase activity
C6I20_RS11465	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C6I20_RS11480	COG0277	FAD linked oxidase domain protein
C6I20_RS11505	COG1335	isochorismatase
C6I20_RS11515	COG0604	alcohol dehydrogenase
C6I20_RS11515	COG3321	synthase
C6I20_RS11530	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_RS11560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6I20_RS11590	COG0604	alcohol dehydrogenase
C6I20_RS11590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C6I20_RS11590	COG3321	synthase
C6I20_RS11590	COG4221	oxidoreductase activity
C6I20_RS11610	COG4585	Histidine kinase
C6I20_RS11615	COG2197	response regulator
C6I20_RS11620	COG0012	GTP binding
C6I20_RS11635	COG1322	Protein conserved in bacteria
C6I20_RS11650	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C6I20_RS11655	COG1570	exodeoxyribonuclease VII activity
C6I20_RS11660	COG1722	exodeoxyribonuclease VII activity
C6I20_RS11700	COG0114	fumarate hydratase activity
C6I20_RS11730	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C6I20_RS11755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C6I20_RS11765	COG1331	Highly conserved protein containing a thioredoxin domain
C6I20_RS11770	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C6I20_RS11770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C6I20_RS11785	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C6I20_RS11790	COG4221	oxidoreductase activity
C6I20_RS11800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6I20_RS11805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6I20_RS11820	COG2315	Protein conserved in bacteria
C6I20_RS11830	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6I20_RS11835	COG3663	DNA glycosylase
C6I20_RS11845	COG1309	transcriptional regulator
C6I20_RS11855	COG1132	(ABC) transporter
C6I20_RS11870	COG2755	lipolytic protein G-D-S-L family
C6I20_RS11880	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C6I20_RS11890	COG0746	molybdenum cofactor guanylyltransferase activity
C6I20_RS11900	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C6I20_RS11935	COG0667	Aldo Keto reductase
C6I20_RS11950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6I20_RS11970	COG0148	phosphopyruvate hydratase activity
C6I20_RS12020	COG1316	TRANSCRIPTIONal
C6I20_RS12040	COG1088	dTDP-glucose 4,6-dehydratase activity
C6I20_RS12045	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C6I20_RS12050	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C6I20_RS12055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C6I20_RS12060	COG2244	polysaccharide biosynthetic process
C6I20_RS12065	COG0438	transferase activity, transferring glycosyl groups
C6I20_RS12075	COG1215	transferase activity, transferring glycosyl groups
C6I20_RS12145	COG0193	aminoacyl-tRNA hydrolase activity
C6I20_RS12150	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C6I20_RS12165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C6I20_RS12180	COG1846	Transcriptional regulator
C6I20_RS12185	COG0488	(ABC) transporter
C6I20_RS12190	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C6I20_RS12195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C6I20_RS12200	COG3583	domain protein
C6I20_RS12205	COG0084	hydrolase, TatD family'
C6I20_RS12210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6I20_RS12240	COG1773	rubredoxin
C6I20_RS12250	COG3239	Fatty acid desaturase
C6I20_RS12275	COG2894	cell division
C6I20_RS12330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6I20_RS12335	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C6I20_RS12345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6I20_RS12360	COG0745	RESPONSE REGULATOR receiver
C6I20_RS12365	COG5002	protein histidine kinase activity
C6I20_RS12375	COG0671	phosphoesterase, PA-phosphatase related
C6I20_RS12390	COG0586	Pfam SNARE associated Golgi protein
C6I20_RS12420	COG0521	Mo-molybdopterin cofactor biosynthetic process
C6I20_RS12420	COG0315	cyclic pyranopterin monophosphate synthase activity
C6I20_RS12425	COG0315	cyclic pyranopterin monophosphate synthase activity
C6I20_RS12440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C6I20_RS12475	COG1970	mechanosensitive ion channel activity
C6I20_RS12500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6I20_RS12520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6I20_RS12565	COG1088	dTDP-glucose 4,6-dehydratase activity
C6I20_RS12575	COG0259	pyridoxamine-phosphate oxidase activity
C6I20_RS12595	COG1305	Transglutaminase-like
C6I20_RS12620	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C6I20_RS12630	COG2252	PERMEase
C6I20_RS12645	COG2814	Major facilitator Superfamily
C6I20_RS12655	COG2814	Major facilitator Superfamily
C6I20_RS12660	COG1278	Cold shock
C6I20_RS12665	COG1295	ribonuclease BN
C6I20_RS12670	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_RS12675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C6I20_RS12680	COG1215	transferase activity, transferring glycosyl groups
C6I20_RS12725	COG1012	belongs to the aldehyde dehydrogenase family
C6I20_RS12750	COG1131	(ABC) transporter
C6I20_RS12755	COG3483	tryptophan 2,3-dioxygenase activity
C6I20_RS12770	COG0459	protein refolding
C6I20_RS12795	COG1278	Cold shock
C6I20_RS12800	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C6I20_RS12835	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C6I20_RS12845	COG0076	glutamate decarboxylase activity
C6I20_RS12865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6I20_RS12875	COG0686	Belongs to the AlaDH PNT family
C6I20_RS12890	COG0738	Major facilitator superfamily
C6I20_RS12910	COG0179	Fumarylacetoacetate (FAA) hydrolase
C6I20_RS12925	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS12930	COG1309	transcriptional regulator
C6I20_RS12935	COG2050	protein possibly involved in aromatic compounds catabolism
C6I20_RS12940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6I20_RS12945	COG2151	metal-sulfur cluster biosynthetic enzyme
C6I20_RS12950	COG3396	Phenylacetate-CoA oxygenase
C6I20_RS12955	COG3460	Phenylacetate-CoA oxygenase
C6I20_RS12960	COG3396	Phenylacetate-CoA oxygenase
C6I20_RS12965	COG2030	dehydratase
C6I20_RS12965	COG1012	belongs to the aldehyde dehydrogenase family
C6I20_RS12995	COG1522	sequence-specific DNA binding
C6I20_RS13015	COG0385	Bile acid
C6I20_RS13040	COG2894	cell division
C6I20_RS13065	COG3850	Histidine kinase
C6I20_RS13070	COG2197	response regulator
C6I20_RS13140	COG0215	cysteine-tRNA ligase activity
C6I20_RS13155	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C6I20_RS13160	COG1329	Transcriptional regulator
C6I20_RS13185	COG0588	phosphoglycerate mutase activity
C6I20_RS13195	COG2855	membrane
C6I20_RS13210	COG0438	transferase activity, transferring glycosyl groups
C6I20_RS13225	COG0477	Major facilitator Superfamily
C6I20_RS13230	COG1846	Transcriptional regulator
C6I20_RS13235	COG1217	gtp-binding protein TYPA
C6I20_RS13250	COG3559	Exporter of polyketide antibiotics
C6I20_RS13255	COG1131	(ABC) transporter
C6I20_RS13295	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C6I20_RS13305	COG0489	protein tyrosine kinase activity
C6I20_RS13310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6I20_RS13315	COG0354	folic acid binding
C6I20_RS13320	COG4044	May play a role in the intracellular transport of hydrophobic ligands
C6I20_RS13325	COG1490	D-aminoacyl-tRNA deacylase activity
C6I20_RS13375	COG0745	RESPONSE REGULATOR receiver
C6I20_RS13385	COG0456	acetyltransferase
C6I20_RS13390	COG0657	acetylesterase activity
C6I20_RS13395	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C6I20_RS13410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C6I20_RS13425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C6I20_RS13430	COG0306	phosphate transporter
C6I20_RS13465	COG0387	Pfam Sodium calcium exchanger
C6I20_RS13480	COG0596	Alpha beta hydrolase
C6I20_RS13525	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6I20_RS13535	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C6I20_RS13560	COG0390	transport system, permease component
C6I20_RS13570	COG0456	acetyltransferase
C6I20_RS13575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6I20_RS13590	COG2409	Drug exporters of the RND superfamily
C6I20_RS13605	COG1174	glycine betaine transport
C6I20_RS13630	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_RS13660	COG2267	carboxylic ester hydrolase activity
C6I20_RS13665	COG2267	carboxylic ester hydrolase activity
C6I20_RS13695	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_RS13705	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6I20_RS13710	COG1129	ABC transporter
C6I20_RS13725	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_RS13730	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_RS13745	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS13760	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C6I20_RS13775	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_RS13790	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C6I20_RS13795	COG1902	pentaerythritol trinitrate reductase activity
C6I20_RS13825	COG1309	transcriptional regulator
C6I20_RS13840	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C6I20_RS13865	COG0513	Belongs to the DEAD box helicase family
C6I20_RS13880	COG0047	phosphoribosylformylglycinamidine synthase activity
C6I20_RS13885	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C6I20_RS13890	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_RS13910	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C6I20_RS13920	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C6I20_RS13925	COG0151	Belongs to the GarS family
C6I20_RS13930	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C6I20_RS13975	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C6I20_RS13980	COG3764	Sortase (surface protein transpeptidase)
C6I20_RS14000	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C6I20_RS14030	COG1605	Chorismate mutase
C6I20_RS14030	COG0287	Prephenate dehydrogenase
C6I20_RS14045	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C6I20_RS14060	COG1754	DNA topoisomerase type I activity
C6I20_RS14060	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C6I20_RS14070	COG1247	-acetyltransferase
C6I20_RS14085	COG2890	protein-(glutamine-N5) methyltransferase activity
C6I20_RS14090	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C6I20_RS14095	COG1366	Belongs to the anti-sigma-factor antagonist family
C6I20_RS14100	COG1205	dead DEAH box helicase
C6I20_RS14100	COG1111	helicase
C6I20_RS14160	COG0110	maltose O-acetyltransferase activity
C6I20_RS14170	COG2226	methyltransferase
C6I20_RS14190	COG0489	protein tyrosine kinase activity
C6I20_RS14195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6I20_RS14210	COG2755	lipolytic protein G-D-S-L family
C6I20_RS14230	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_RS14265	COG1268	BioY protein
C6I20_RS14270	COG1122	ATPase activity
C6I20_RS14280	COG3275	phosphorelay sensor kinase activity
C6I20_RS14295	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6I20_RS14305	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6I20_RS14310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6I20_RS14330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6I20_RS14340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C6I20_RS14355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6I20_RS14390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6I20_RS14400	COG1408	metallophosphoesterase
C6I20_RS14435	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C6I20_RS14480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6I20_RS14500	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C6I20_RS14515	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C6I20_RS14535	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS14540	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS14565	COG1609	Transcriptional regulator
C6I20_RS14570	COG1653	transport
C6I20_RS14575	COG1175	transmembrane transport
C6I20_RS14580	COG0395	ABC-type sugar transport system, permease component
C6I20_RS14590	COG3842	ATPase activity
C6I20_RS14600	COG0596	Alpha beta hydrolase
C6I20_RS14605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C6I20_RS14610	COG4134	Bacterial extracellular solute-binding protein
C6I20_RS14625	COG3842	ATPase activity
C6I20_RS14655	COG2045	Belongs to the ComB family
C6I20_RS14665	COG0433	COG0433 Predicted ATPase
C6I20_RS14680	COG3263	regulation of cellular component size
C6I20_RS14695	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_RS14710	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C6I20_RS14750	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C6I20_RS14755	COG0659	secondary active sulfate transmembrane transporter activity
C6I20_RS14760	COG0789	Transcriptional regulator
C6I20_RS14795	COG1072	(Pantothenic acid kinase))
C6I20_RS14805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6I20_RS14815	COG0590	tRNA wobble adenosine to inosine editing
C6I20_RS14820	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C6I20_RS14825	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C6I20_RS14830	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C6I20_RS14835	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C6I20_RS14840	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_RS14855	COG0583	DNA-binding transcription factor activity
C6I20_RS14870	COG1012	belongs to the aldehyde dehydrogenase family
C6I20_RS14875	COG1177	transmembrane transport
C6I20_RS14880	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6I20_RS14885	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C6I20_RS14890	COG3842	ATPase activity
C6I20_RS14915	COG2890	protein-(glutamine-N5) methyltransferase activity
C6I20_RS14920	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C6I20_RS14955	COG0681	Belongs to the peptidase S26 family
C6I20_RS14965	COG0038	chloride channel
C6I20_RS14970	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C6I20_RS14975	COG0738	Major facilitator superfamily
C6I20_RS14990	COG1335	isochorismatase
C6I20_RS14995	COG1802	Transcriptional regulator
C6I20_RS15000	COG0277	FAD linked oxidase domain protein
C6I20_RS15030	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C6I20_RS15035	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C6I20_RS15090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C6I20_RS15105	COG0604	alcohol dehydrogenase
C6I20_RS15120	COG0561	phosphatase activity
C6I20_RS15125	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C6I20_RS15135	COG0596	Alpha beta hydrolase
C6I20_RS15140	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C6I20_RS15165	COG2235	arginine
C6I20_RS15190	COG0776	regulation of translation
C6I20_RS15195	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C6I20_RS15210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6I20_RS15220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6I20_RS15225	COG1309	transcriptional regulator
C6I20_RS15235	COG0583	DNA-binding transcription factor activity
C6I20_RS15240	COG0477	Major facilitator Superfamily
C6I20_RS15285	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C6I20_RS15305	COG1716	ATPase activity
C6I20_RS15310	COG1716	ATPase activity
C6I20_RS15325	COG0768	penicillin binding
C6I20_RS15330	COG0515	serine threonine protein kinase
C6I20_RS15345	COG0705	Rhomboid family
C6I20_RS15365	COG1024	Enoyl-CoA hydratase
C6I20_RS15380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C6I20_RS15385	COG4166	transmembrane transport
C6I20_RS15390	COG0601	transmembrane transport
C6I20_RS15400	COG2755	lipolytic protein G-D-S-L family
C6I20_RS15405	COG2318	DinB family
C6I20_RS15435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6I20_RS15460	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C6I20_RS15465	COG0187	DNA topoisomerase II activity
C6I20_RS15475	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C6I20_RS15480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C6I20_RS15485	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C6I20_RS15490	COG0592	DNA-directed DNA polymerase activity
C6I20_RS15495	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C6I20_RS15505	COG0594	ribonuclease P activity
C6I20_RS15510	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C6I20_RS15515	COG0706	membrane insertase activity
C6I20_RS15525	COG0357	Ribosomal RNA small subunit methyltransferase G
C6I20_RS15530	COG1192	Involved in chromosome partitioning
C6I20_RS15540	COG1879	ABC-type sugar transport system periplasmic component
C6I20_RS15545	COG1129	ABC transporter
C6I20_RS15550	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6I20_RS15555	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6I20_RS15565	COG0318	PFAM AMP-dependent synthetase and ligase
C6I20_RS15570	COG3118	belongs to the thioredoxin family
C6I20_RS15575	COG0492	ferredoxin-NADP+ reductase activity
C6I20_RS15580	COG2815	serine threonine protein kinase
C6I20_RS15580	COG0515	serine threonine protein kinase
C6I20_RS15595	COG0617	tRNA 3'-terminal CCA addition
C6I20_RS15615	COG1022	Amp-dependent synthetase and ligase
C6I20_RS15625	COG0410	ABC transporter
C6I20_RS15645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6I20_RS15655	COG2348	transferase activity, transferring amino-acyl groups
C6I20_RS15675	COG1305	Transglutaminase-like
C6I20_RS15685	COG0667	Aldo Keto reductase
C6I20_RS15695	COG0577	efflux transmembrane transporter activity
C6I20_RS15695	COG1136	(ABC) transporter
C6I20_RS15700	COG0577	efflux transmembrane transporter activity
C6I20_RS15705	COG0360	Binds together with S18 to 16S ribosomal RNA
C6I20_RS15710	COG0629	single-stranded DNA binding
C6I20_RS15715	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C6I20_RS15720	COG0359	binds to the 23S rRNA
C6I20_RS15740	COG0305	Participates in initiation and elongation during chromosome replication
C6I20_RS15750	COG0586	Pfam SNARE associated Golgi protein
C6I20_RS15765	COG1132	(ABC) transporter
C6I20_RS15770	COG3126	Type III secretion system lipoprotein chaperone (YscW)
C6I20_RS15780	COG1937	Protein conserved in bacteria
C6I20_RS15810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6I20_RS15830	COG1902	pentaerythritol trinitrate reductase activity
C6I20_RS15830	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6I20_RS15865	COG0640	Transcriptional regulator
C6I20_RS15885	COG2197	response regulator
C6I20_RS15905	COG0633	Ferredoxin
C6I20_RS15965	COG1119	ATPase activity
C6I20_RS15975	COG0596	Alpha beta hydrolase
C6I20_RS15980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6I20_RS15990	COG1116	anion transmembrane transporter activity
C6I20_RS16005	COG0183	Belongs to the thiolase family
C6I20_RS16010	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6I20_RS16010	COG1024	Enoyl-CoA hydratase
C6I20_RS16050	COG0702	epimerase
C6I20_RS16070	COG1028	Short-chain dehydrogenase reductase Sdr
C6I20_RS16090	COG1024	Enoyl-CoA hydratase
C6I20_RS16125	COG0300	oxidoreductase activity
C6I20_RS16155	COG2072	flavoprotein involved in K transport
C6I20_RS16160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C6I20_RS16165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6I20_RS16180	COG2072	flavoprotein involved in K transport
C6I20_RS16185	COG1131	(ABC) transporter
C6I20_RS16200	COG4585	Histidine kinase
C6I20_RS16205	COG2197	response regulator
C6I20_RS16215	COG0657	acetylesterase activity
C6I20_RS16240	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS16245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6I20_RS16265	COG0765	amino acid transport
C6I20_RS16270	COG1126	abc transporter atp-binding protein
C6I20_RS16285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6I20_RS16330	COG0697	spore germination
C6I20_RS16335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6I20_RS16340	COG2205	protein histidine kinase activity
C6I20_RS16345	COG0745	RESPONSE REGULATOR receiver
C6I20_RS16360	COG1950	PFAM Membrane protein of
C6I20_RS16365	COG0697	spore germination
C6I20_RS16370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C6I20_RS16380	COG0022	dehydrogenase e1 component
C6I20_RS16385	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6I20_RS16420	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C6I20_RS16425	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C6I20_RS16455	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C6I20_RS16460	COG4988	ABC transporter
C6I20_RS16465	COG1294	oxidase, subunit
C6I20_RS16470	COG1271	oxidase subunit
C6I20_RS16485	COG1846	Transcriptional regulator
C6I20_RS16490	COG1960	acyl-CoA dehydrogenase activity
C6I20_RS16510	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C6I20_RS16515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C6I20_RS16520	COG5002	protein histidine kinase activity
C6I20_RS16525	COG0745	RESPONSE REGULATOR receiver
C6I20_RS16570	COG1063	alcohol dehydrogenase
C6I20_RS16575	COG0579	oxidoreductase
C6I20_RS16585	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6I20_RS16585	COG1024	Enoyl-CoA hydratase
C6I20_RS16590	COG0717	Belongs to the dCTP deaminase family
C6I20_RS16595	COG2313	pseudouridylate synthase activity
C6I20_RS16600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6I20_RS16605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6I20_RS16610	COG2942	2-epimerase
C6I20_RS16640	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C6I20_RS16655	COG1228	amidohydrolase
C6I20_RS16660	COG3012	SEC-C Motif Domain Protein
C6I20_RS16665	COG2181	nitrate reductase activity
C6I20_RS16665	COG0247	lactate metabolic process
C6I20_RS16670	COG2271	Major facilitator Superfamily
C6I20_RS16685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6I20_RS16720	COG1122	ATPase activity
C6I20_RS16765	COG0154	amidase activity
C6I20_RS16770	COG1054	Belongs to the UPF0176 family
C6I20_RS16775	COG1309	transcriptional regulator
C6I20_RS16785	COG2271	Major facilitator Superfamily
C6I20_RS16795	COG2409	Drug exporters of the RND superfamily
C6I20_RS16810	COG0443	Heat shock 70 kDa protein
C6I20_RS16815	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C6I20_RS16820	COG0484	heat shock protein binding
C6I20_RS16825	COG0789	Transcriptional regulator
C6I20_RS16845	COG0463	Glycosyl transferase, family 2
C6I20_RS16855	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C6I20_RS16870	COG1902	pentaerythritol trinitrate reductase activity
C6I20_RS16895	COG0318	PFAM AMP-dependent synthetase and ligase