locus-tag	class	description
O3S82_RS00015	COG0586	Pfam SNARE associated Golgi protein
O3S82_RS00040	COG1132	(ABC) transporter
O3S82_RS00070	COG1937	Protein conserved in bacteria
O3S82_RS00080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O3S82_RS00100	COG0446	pyridine nucleotide-disulphide oxidoreductase
O3S82_RS00100	COG1902	pentaerythritol trinitrate reductase activity
O3S82_RS00125	COG0765	amino acid transport
O3S82_RS00135	COG2267	carboxylic ester hydrolase activity
O3S82_RS00140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O3S82_RS00155	COG2814	Major facilitator Superfamily
O3S82_RS00160	COG0444	Belongs to the ABC transporter superfamily
O3S82_RS00175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O3S82_RS00180	COG0747	negative chemotaxis
O3S82_RS00185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O3S82_RS00200	COG1028	Short-chain dehydrogenase reductase Sdr
O3S82_RS00205	COG2030	dehydratase
O3S82_RS00210	COG1309	transcriptional regulator
O3S82_RS00240	COG0438	transferase activity, transferring glycosyl groups
O3S82_RS00270	COG0183	Belongs to the thiolase family
O3S82_RS00275	COG1024	Enoyl-CoA hydratase
O3S82_RS00275	COG1250	3-hydroxyacyl-CoA dehydrogenase
O3S82_RS00295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O3S82_RS00300	COG0489	protein tyrosine kinase activity
O3S82_RS00310	COG0531	amino acid
O3S82_RS00320	COG3629	intracellular signal transduction
O3S82_RS00320	COG3903	Transcriptional regulator
O3S82_RS00325	COG2409	Drug exporters of the RND superfamily
O3S82_RS00330	COG0702	epimerase
O3S82_RS00335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O3S82_RS00345	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
O3S82_RS00345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O3S82_RS00345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O3S82_RS00370	COG1024	Enoyl-CoA hydratase
O3S82_RS00385	COG3321	synthase
O3S82_RS00385	COG1028	Short-chain dehydrogenase reductase Sdr
O3S82_RS00385	COG0604	alcohol dehydrogenase
O3S82_RS00405	COG0318	PFAM AMP-dependent synthetase and ligase
O3S82_RS00415	COG1879	ABC-type sugar transport system periplasmic component
O3S82_RS00420	COG1129	ABC transporter
O3S82_RS00425	COG1172	Belongs to the binding-protein-dependent transport system permease family
O3S82_RS00435	COG1028	Short-chain dehydrogenase reductase Sdr
O3S82_RS00465	COG2130	NADP-dependent
O3S82_RS00475	COG0513	Belongs to the DEAD box helicase family
O3S82_RS00480	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O3S82_RS00500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O3S82_RS00515	COG0657	acetylesterase activity
O3S82_RS00575	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS00580	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS00585	COG1024	Enoyl-CoA hydratase
O3S82_RS00590	COG1024	Enoyl-CoA hydratase
O3S82_RS00690	COG0183	Belongs to the thiolase family
O3S82_RS00700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O3S82_RS00705	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS00715	COG1024	Enoyl-CoA hydratase
O3S82_RS00720	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
O3S82_RS00735	COG0589	response to stress
O3S82_RS00745	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS00755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O3S82_RS00800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O3S82_RS00810	COG0745	RESPONSE REGULATOR receiver
O3S82_RS00815	COG3001	Fructosamine kinase
O3S82_RS00825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O3S82_RS00835	COG0697	spore germination
O3S82_RS00840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O3S82_RS00850	COG0022	dehydrogenase e1 component
O3S82_RS00855	COG0508	dehydrogenase complex catalyzes the overall conversion of
O3S82_RS00885	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS00890	COG0583	DNA-binding transcription factor activity
O3S82_RS00905	COG2233	PERMEase
O3S82_RS01310	COG0717	Belongs to the dCTP deaminase family
O3S82_RS01315	COG0561	phosphatase activity
O3S82_RS01345	COG2313	pseudouridylate synthase activity
O3S82_RS01355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O3S82_RS01400	COG0318	PFAM AMP-dependent synthetase and ligase
O3S82_RS01410	COG1028	Short-chain dehydrogenase reductase Sdr
O3S82_RS01415	COG1028	Short-chain dehydrogenase reductase Sdr
O3S82_RS01420	COG2181	nitrate reductase activity
O3S82_RS01420	COG0247	lactate metabolic process
O3S82_RS01425	COG2271	Major facilitator Superfamily
O3S82_RS01445	COG3845	ABC transporter
O3S82_RS01465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O3S82_RS01470	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O3S82_RS01515	COG3764	Sortase (surface protein transpeptidase)
O3S82_RS01530	COG1028	Short-chain dehydrogenase reductase Sdr
O3S82_RS01545	COG0154	amidase activity
O3S82_RS01565	COG2252	PERMEase
O3S82_RS01570	COG2409	Drug exporters of the RND superfamily
O3S82_RS01575	COG2072	flavoprotein involved in K transport
O3S82_RS01580	COG1309	transcriptional regulator
O3S82_RS01590	COG1136	(ABC) transporter
O3S82_RS01590	COG0577	efflux transmembrane transporter activity
O3S82_RS01595	COG2197	response regulator
O3S82_RS01600	COG4585	Histidine kinase
O3S82_RS01605	COG0443	Heat shock 70 kDa protein
O3S82_RS01610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
O3S82_RS01615	COG0484	heat shock protein binding
O3S82_RS01620	COG0789	Transcriptional regulator
O3S82_RS01645	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
O3S82_RS01650	COG0318	PFAM AMP-dependent synthetase and ligase
O3S82_RS01655	COG2040	homocysteine
O3S82_RS01675	COG0737	Belongs to the 5'-nucleotidase family
O3S82_RS01725	COG1017	nitric oxide dioxygenase activity
O3S82_RS01725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O3S82_RS01740	COG2226	methyltransferase
O3S82_RS01755	COG1063	alcohol dehydrogenase
O3S82_RS01790	COG0542	response to heat
O3S82_RS01800	COG1252	NADH dehydrogenase
O3S82_RS01820	COG1120	ATPase activity
O3S82_RS01825	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O3S82_RS01830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O3S82_RS01875	COG3845	ABC transporter
O3S82_RS01890	COG1940	carbohydrate kinase activity
O3S82_RS01895	COG1129	ABC transporter
O3S82_RS01900	COG1172	Belongs to the binding-protein-dependent transport system permease family
O3S82_RS01920	COG0673	inositol 2-dehydrogenase activity
O3S82_RS01935	COG2818	Glycosylase
O3S82_RS01940	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
O3S82_RS01960	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
O3S82_RS01980	COG0037	tRNA processing
O3S82_RS01995	COG0302	gtp cyclohydrolase
O3S82_RS02000	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
O3S82_RS02010	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
O3S82_RS02015	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
O3S82_RS02035	COG1216	Glycosyl transferase, family 2
O3S82_RS02045	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O3S82_RS02070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O3S82_RS02080	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
O3S82_RS02085	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
O3S82_RS02095	COG2409	Drug exporters of the RND superfamily
O3S82_RS02100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O3S82_RS02125	COG0438	transferase activity, transferring glycosyl groups
O3S82_RS02140	COG0588	phosphoglycerate mutase activity
O3S82_RS02145	COG0745	RESPONSE REGULATOR receiver
O3S82_RS02150	COG5002	protein histidine kinase activity
O3S82_RS02165	COG1329	Transcriptional regulator
O3S82_RS02170	COG1309	transcriptional regulator
O3S82_RS02180	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
O3S82_RS02190	COG0215	cysteine-tRNA ligase activity
O3S82_RS02245	COG0628	permease
O3S82_RS02250	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
O3S82_RS02255	COG2223	nitrite transmembrane transporter activity
O3S82_RS02270	COG0076	glutamate decarboxylase activity
O3S82_RS02280	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
O3S82_RS02305	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
O3S82_RS02310	COG1278	Cold shock
O3S82_RS02315	COG0459	protein refolding
O3S82_RS02325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O3S82_RS02340	COG0529	Catalyzes the synthesis of activated sulfate
O3S82_RS02350	COG1012	belongs to the aldehyde dehydrogenase family
O3S82_RS02360	COG0318	PFAM AMP-dependent synthetase and ligase
O3S82_RS02375	COG1278	Cold shock
O3S82_RS02405	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
O3S82_RS02430	COG1305	Transglutaminase-like
O3S82_RS02435	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
O3S82_RS02435	COG2755	lipolytic protein G-D-S-L family
O3S82_RS02460	COG0259	pyridoxamine-phosphate oxidase activity
O3S82_RS02490	COG0673	inositol 2-dehydrogenase activity
O3S82_RS02505	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
O3S82_RS02520	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O3S82_RS02525	COG2755	lipolytic protein G-D-S-L family
O3S82_RS02525	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
O3S82_RS02570	COG2197	response regulator
O3S82_RS02575	COG4585	Histidine kinase
O3S82_RS02640	COG0358	DNA primase activity
O3S82_RS02690	COG0519	Catalyzes the synthesis of GMP from XMP
O3S82_RS02690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O3S82_RS02705	COG4941	Belongs to the sigma-70 factor family
O3S82_RS02715	COG0039	L-malate dehydrogenase activity
O3S82_RS02725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O3S82_RS02740	COG0138	bifunctional purine biosynthesis protein purh
O3S82_RS02765	COG0045	succinate-CoA ligase (ADP-forming) activity
O3S82_RS02790	COG2197	response regulator
O3S82_RS02795	COG2205	protein histidine kinase activity
O3S82_RS02810	COG1983	PspC domain protein
O3S82_RS02815	COG0584	glycerophosphoryl diester phosphodiesterase
O3S82_RS02830	COG2814	Major facilitator Superfamily
O3S82_RS02835	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
O3S82_RS02840	COG4208	sulfate ABC transporter
O3S82_RS02850	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
O3S82_RS02855	COG2838	Isocitrate dehydrogenase
O3S82_RS02865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O3S82_RS02885	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
O3S82_RS02890	COG0180	Tryptophanyl-tRNA synthetase
O3S82_RS02900	COG0583	DNA-binding transcription factor activity
O3S82_RS02910	COG1053	succinate dehydrogenase
O3S82_RS02915	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
O3S82_RS02960	COG1846	Transcriptional regulator
O3S82_RS02965	COG2211	Major facilitator Superfamily
O3S82_RS02980	COG1473	amidohydrolase
O3S82_RS02980	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
O3S82_RS02990	COG1744	ABC transporter substrate-binding protein PnrA-like
O3S82_RS02995	COG3845	ABC transporter
O3S82_RS03000	COG4603	Belongs to the binding-protein-dependent transport system permease family
O3S82_RS03005	COG1079	Belongs to the binding-protein-dependent transport system permease family
O3S82_RS03030	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
O3S82_RS03040	COG1012	belongs to the aldehyde dehydrogenase family
O3S82_RS03045	COG1012	belongs to the aldehyde dehydrogenase family
O3S82_RS03060	COG1940	carbohydrate kinase activity
O3S82_RS03065	COG1846	Transcriptional regulator
O3S82_RS03065	COG1940	carbohydrate kinase activity
O3S82_RS03075	COG1172	Belongs to the binding-protein-dependent transport system permease family
O3S82_RS03090	COG1070	Carbohydrate kinase
O3S82_RS03095	COG0673	inositol 2-dehydrogenase activity
O3S82_RS03100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O3S82_RS03130	COG4558	Periplasmic binding protein
O3S82_RS03135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O3S82_RS03140	COG1120	ATPase activity
O3S82_RS03145	COG5398	heme oxygenase
O3S82_RS03155	COG2247	cell wall binding repeat
O3S82_RS03155	COG2385	sporulation resulting in formation of a cellular spore
O3S82_RS03165	COG1937	Protein conserved in bacteria
O3S82_RS03185	COG4770	biotin carboxylase activity
O3S82_RS03190	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS03210	COG0424	maF-like protein
O3S82_RS03225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O3S82_RS03240	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
O3S82_RS03260	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS03290	COG1316	TRANSCRIPTIONal
O3S82_RS03300	COG1316	TRANSCRIPTIONal
O3S82_RS03305	COG1134	teichoic acid transport
O3S82_RS03345	COG2835	tetraacyldisaccharide 4'-kinase activity
O3S82_RS03380	COG2353	YceI-like domain
O3S82_RS03395	COG0183	Belongs to the thiolase family
O3S82_RS03400	COG1028	Short-chain dehydrogenase reductase Sdr
O3S82_RS03405	COG2030	dehydratase
O3S82_RS03410	COG0736	holo-[acyl-carrier-protein] synthase activity
O3S82_RS03430	COG1028	Short-chain dehydrogenase reductase Sdr
O3S82_RS03435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O3S82_RS03440	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
O3S82_RS03455	COG0668	transmembrane transport
O3S82_RS03505	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
O3S82_RS03510	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
O3S82_RS03510	COG0778	Nitroreductase
O3S82_RS03515	COG0391	Required for morphogenesis under gluconeogenic growth conditions
O3S82_RS03530	COG1920	GTP binding
O3S82_RS03535	COG2072	flavoprotein involved in K transport
O3S82_RS03540	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
O3S82_RS03545	COG2884	Cell division ATP-binding protein ftsE
O3S82_RS03560	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
O3S82_RS03575	COG1902	pentaerythritol trinitrate reductase activity
O3S82_RS03590	COG1278	Cold shock
O3S82_RS03600	COG0475	glutathione-regulated potassium exporter activity
O3S82_RS03600	COG0569	domain protein
O3S82_RS03660	COG2072	flavoprotein involved in K transport
O3S82_RS03670	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O3S82_RS03675	COG1201	RNA secondary structure unwinding
O3S82_RS03690	COG1678	Uncharacterized ACR, COG1678
O3S82_RS03705	COG0657	acetylesterase activity
O3S82_RS03720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O3S82_RS03725	COG1335	isochorismatase
O3S82_RS03735	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
O3S82_RS03760	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
O3S82_RS03765	COG1846	Transcriptional regulator
O3S82_RS03770	COG1764	response to oxidative stress
O3S82_RS03775	COG2211	Major facilitator Superfamily
O3S82_RS03785	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
O3S82_RS03790	COG1234	tRNA 3'-trailer cleavage
O3S82_RS03800	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
O3S82_RS03805	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
O3S82_RS03840	COG4122	O-methyltransferase activity
O3S82_RS03850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O3S82_RS03865	COG2239	Acts as a magnesium transporter
O3S82_RS03875	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS03890	COG2030	dehydratase
O3S82_RS03895	COG0406	alpha-ribazole phosphatase activity
O3S82_RS03900	COG0613	PHP domain protein
O3S82_RS03940	COG3559	Exporter of polyketide antibiotics
O3S82_RS03945	COG1131	(ABC) transporter
O3S82_RS03975	COG1309	transcriptional regulator
O3S82_RS03990	COG0210	DNA helicase
O3S82_RS03995	COG0210	DNA helicase
O3S82_RS04000	COG2816	NAD+ diphosphatase activity
O3S82_RS04025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O3S82_RS04055	COG3480	Lon protease (S16) C-terminal proteolytic domain
O3S82_RS04065	COG1615	UPF0182 protein
O3S82_RS04070	COG0442	prolyl-tRNA aminoacylation
O3S82_RS04075	COG0028	Belongs to the TPP enzyme family
O3S82_RS04095	COG1012	belongs to the aldehyde dehydrogenase family
O3S82_RS04185	COG4942	peptidase
O3S82_RS04270	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
O3S82_RS04295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
O3S82_RS04315	COG1024	Enoyl-CoA hydratase
O3S82_RS04320	COG1024	Enoyl-CoA hydratase
O3S82_RS04340	COG0411	ABC transporter
O3S82_RS04345	COG0559	Belongs to the binding-protein-dependent transport system permease family
O3S82_RS04365	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS04375	COG0183	Belongs to the thiolase family
O3S82_RS04380	COG1028	Short-chain dehydrogenase reductase Sdr
O3S82_RS04395	COG1309	transcriptional regulator
O3S82_RS04415	COG1024	Enoyl-CoA hydratase
O3S82_RS04425	COG1028	Short-chain dehydrogenase reductase Sdr
O3S82_RS04525	COG1234	tRNA 3'-trailer cleavage
O3S82_RS04535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O3S82_RS04540	COG1414	Transcriptional regulator
O3S82_RS04550	COG0179	Fumarylacetoacetate (FAA) hydrolase
O3S82_RS04555	COG0346	lactoylglutathione lyase activity
O3S82_RS04560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O3S82_RS04570	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS04605	COG1129	ABC transporter
O3S82_RS04610	COG1172	Belongs to the binding-protein-dependent transport system permease family
O3S82_RS04625	COG1028	Short-chain dehydrogenase reductase Sdr
O3S82_RS04635	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
O3S82_RS04645	COG1984	allophanate hydrolase subunit 2
O3S82_RS04650	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O3S82_RS04675	COG0686	Belongs to the AlaDH PNT family
O3S82_RS04700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O3S82_RS04730	COG4176	ABC-type proline glycine betaine transport system permease component
O3S82_RS04745	COG2909	trisaccharide binding
O3S82_RS04830	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
O3S82_RS04835	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
O3S82_RS04840	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
O3S82_RS04850	COG1403	HNH endonuclease
O3S82_RS04895	COG2323	membrane
O3S82_RS04910	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
O3S82_RS04915	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
O3S82_RS04970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O3S82_RS04980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O3S82_RS04990	COG0318	PFAM AMP-dependent synthetase and ligase
O3S82_RS04995	COG1309	transcriptional regulator
O3S82_RS05020	COG0723	plastoquinol--plastocyanin reductase activity
O3S82_RS05020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O3S82_RS05040	COG1028	Short-chain dehydrogenase reductase Sdr
O3S82_RS05045	COG2890	protein-(glutamine-N5) methyltransferase activity
O3S82_RS05075	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS05085	COG0318	PFAM AMP-dependent synthetase and ligase
O3S82_RS05115	COG0419	ATPase involved in DNA repair
O3S82_RS05125	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O3S82_RS05125	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O3S82_RS05125	COG1703	isobutyryl-CoA mutase activity
O3S82_RS05160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
O3S82_RS05175	COG2860	membrane
O3S82_RS05180	COG1132	(ABC) transporter
O3S82_RS05195	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS05225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O3S82_RS05230	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
O3S82_RS05245	COG0483	inositol monophosphate 1-phosphatase activity
O3S82_RS05250	COG1162	GTPase activity
O3S82_RS05255	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
O3S82_RS05275	COG2135	peptidase activity
O3S82_RS05280	COG1595	DNA-templated transcription, initiation
O3S82_RS05320	COG0604	alcohol dehydrogenase
O3S82_RS05330	COG0567	Dehydrogenase, E1 component
O3S82_RS05330	COG0508	dehydrogenase complex catalyzes the overall conversion of
O3S82_RS05335	COG1764	response to oxidative stress
O3S82_RS05340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O3S82_RS05365	COG1131	(ABC) transporter
O3S82_RS05385	COG2201	protein-glutamate methylesterase activity
O3S82_RS05390	COG0018	arginyl-trna synthetase
O3S82_RS05405	COG0460	homoserine dehydrogenase
O3S82_RS05410	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
O3S82_RS05415	COG0083	homoserine kinase activity
O3S82_RS05425	COG0386	Belongs to the glutathione peroxidase family
O3S82_RS05435	COG0254	rRNA binding
O3S82_RS05440	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
O3S82_RS05445	COG2890	protein-(glutamine-N5) methyltransferase activity
O3S82_RS05455	COG0009	L-threonylcarbamoyladenylate synthase
O3S82_RS05475	COG0356	it plays a direct role in the translocation of protons across the membrane
O3S82_RS05480	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O3S82_RS05485	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
O3S82_RS05490	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O3S82_RS05495	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
O3S82_RS05500	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
O3S82_RS05505	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O3S82_RS05510	COG0355	proton-transporting ATP synthase activity, rotational mechanism
O3S82_RS05530	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O3S82_RS05530	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O3S82_RS05540	COG1528	Iron-storage protein
O3S82_RS05550	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
O3S82_RS05560	COG1250	3-hydroxyacyl-CoA dehydrogenase
O3S82_RS05595	COG0183	Belongs to the thiolase family
O3S82_RS05635	COG2086	electron transfer activity
O3S82_RS05640	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
O3S82_RS05645	COG0747	negative chemotaxis
O3S82_RS05650	COG0601	transmembrane transport
O3S82_RS05655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O3S82_RS05670	COG1309	transcriptional regulator
O3S82_RS05685	COG0587	DNA-directed DNA polymerase activity
O3S82_RS05700	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
O3S82_RS05705	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
O3S82_RS05715	COG1104	cysteine desulfurase activity
O3S82_RS05755	COG1674	ftsk spoiiie
O3S82_RS05825	COG0482	sulfurtransferase activity
O3S82_RS05850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O3S82_RS05865	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O3S82_RS05870	COG0154	amidase activity
O3S82_RS05875	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O3S82_RS05900	COG2161	toxin-antitoxin pair type II binding
O3S82_RS05905	COG4115	mRNA cleavage
O3S82_RS05930	COG1643	Atp-dependent helicase
O3S82_RS05965	COG2197	response regulator
O3S82_RS05970	COG4585	Histidine kinase
O3S82_RS06005	COG0129	dihydroxy-acid dehydratase activity
O3S82_RS06025	COG0440	acetolactate synthase activity
O3S82_RS06030	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
O3S82_RS06040	COG0531	amino acid
O3S82_RS06045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O3S82_RS06055	COG2364	Membrane
O3S82_RS06075	COG0473	3-isopropylmalate dehydrogenase activity
O3S82_RS06080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O3S82_RS06085	COG1704	LemA family
O3S82_RS06095	COG0137	argininosuccinate synthase activity
O3S82_RS06100	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
O3S82_RS06105	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
O3S82_RS06110	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O3S82_RS06115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O3S82_RS06120	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
O3S82_RS06125	COG1438	arginine binding
O3S82_RS06130	COG0165	Argininosuccinate lyase
O3S82_RS06140	COG4565	transcriptional regulatory protein
O3S82_RS06145	COG3290	protein histidine kinase activity
O3S82_RS06165	COG0589	response to stress
O3S82_RS06190	COG0589	response to stress
O3S82_RS06200	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O3S82_RS06230	COG0647	UMP catabolic process
O3S82_RS06245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O3S82_RS06250	COG0497	DNA recombination
O3S82_RS06265	COG0504	CTP synthase activity
O3S82_RS06270	COG0494	nUDIX hydrolase
O3S82_RS06295	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
O3S82_RS06310	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
O3S82_RS06315	COG0228	four-way junction DNA binding
O3S82_RS06320	COG1837	Belongs to the UPF0109 family
O3S82_RS06325	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
O3S82_RS06330	COG0336	Belongs to the RNA methyltransferase TrmD family
O3S82_RS06340	COG0335	large ribosomal subunit rRNA binding
O3S82_RS06355	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O3S82_RS06370	COG0792	nuclease activity
O3S82_RS06390	COG0521	Mo-molybdopterin cofactor biosynthetic process
O3S82_RS06395	COG0315	cyclic pyranopterin monophosphate synthase activity
O3S82_RS06430	COG0741	lytic transglycosylase activity
O3S82_RS06430	COG0739	heme binding
O3S82_RS06430	COG1196	nuclear chromosome segregation
O3S82_RS06435	COG0052	Belongs to the universal ribosomal protein uS2 family
O3S82_RS06440	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
O3S82_RS06445	COG0528	UMP kinase activity
O3S82_RS06450	COG0233	cytoplasmic translational termination
O3S82_RS06460	COG2307	Protein conserved in bacteria
O3S82_RS06460	COG2308	Evidence 4 Homologs of previously reported genes of
O3S82_RS06475	COG0820	rRNA (adenine-C2-)-methyltransferase activity
O3S82_RS06495	COG2197	response regulator
O3S82_RS06505	COG1131	(ABC) transporter
O3S82_RS06530	COG0750	zinc metalloprotease
O3S82_RS06535	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
O3S82_RS06550	COG0442	prolyl-tRNA aminoacylation
O3S82_RS06570	COG0779	Required for maturation of 30S ribosomal subunits
O3S82_RS06585	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
O3S82_RS06590	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
O3S82_RS06595	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
O3S82_RS06610	COG0515	serine threonine protein kinase
O3S82_RS06610	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O3S82_RS06620	COG2205	protein histidine kinase activity
O3S82_RS06635	COG3185	4-Hydroxyphenylpyruvate dioxygenase
O3S82_RS06670	COG1185	polyribonucleotide nucleotidyltransferase activity
O3S82_RS06680	COG1175	transmembrane transport
O3S82_RS06700	COG3842	ATPase activity
O3S82_RS06705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
O3S82_RS06730	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
O3S82_RS06750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O3S82_RS06755	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
O3S82_RS06765	COG1674	ftsk spoiiie
O3S82_RS06785	COG1058	Belongs to the CinA family
O3S82_RS06785	COG1546	Belongs to the CinA family
O3S82_RS06790	COG1396	sequence-specific DNA binding
O3S82_RS06800	COG0693	protein deglycase activity
O3S82_RS06805	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
O3S82_RS06810	COG2137	regulation of response to DNA damage stimulus
O3S82_RS06825	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
O3S82_RS06830	COG0765	amino acid transport
O3S82_RS06835	COG0765	amino acid transport
O3S82_RS06840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O3S82_RS06845	COG1126	abc transporter atp-binding protein
O3S82_RS06865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O3S82_RS06870	COG0070	glutamate synthase
O3S82_RS06870	COG0069	glutamate synthase activity
O3S82_RS06870	COG0067	glutamate synthase
O3S82_RS06880	COG0469	pyruvate kinase activity
O3S82_RS06915	COG0559	Belongs to the binding-protein-dependent transport system permease family
O3S82_RS06945	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
O3S82_RS06950	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
O3S82_RS06950	COG2755	lipolytic protein G-D-S-L family
O3S82_RS06955	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
O3S82_RS06955	COG2755	lipolytic protein G-D-S-L family
O3S82_RS06975	COG1216	Glycosyl transferase, family 2
O3S82_RS06980	COG0438	transferase activity, transferring glycosyl groups
O3S82_RS06995	COG4981	capsule polysaccharide biosynthetic process
O3S82_RS07010	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
O3S82_RS07040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
O3S82_RS07045	COG1362	aminopeptidase activity
O3S82_RS07055	COG0539	negative regulation of cytoplasmic translation
O3S82_RS07080	COG0237	dephospho-CoA kinase activity
O3S82_RS07095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O3S82_RS07165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O3S82_RS07200	COG0477	Major facilitator Superfamily
O3S82_RS07210	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O3S82_RS07230	COG1435	thymidine kinase activity
O3S82_RS07245	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
O3S82_RS07270	COG0756	dUTP diphosphatase activity
O3S82_RS07295	COG0569	domain protein
O3S82_RS07300	COG0531	amino acid
O3S82_RS07305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O3S82_RS07315	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
O3S82_RS07325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O3S82_RS07335	COG1946	Acyl-CoA thioesterase
O3S82_RS07350	COG0183	Belongs to the thiolase family
O3S82_RS07375	COG0556	nucleotide-excision repair
O3S82_RS07385	COG0531	amino acid
O3S82_RS07390	COG2124	cytochrome p450
O3S82_RS07400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
O3S82_RS07405	COG0322	excinuclease ABC activity
O3S82_RS07410	COG1660	Displays ATPase and GTPase activities
O3S82_RS07420	COG1481	regulation of sporulation
O3S82_RS07425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O3S82_RS07430	COG0126	phosphoglycerate kinase activity
O3S82_RS07435	COG0149	triose-phosphate isomerase activity
O3S82_RS07440	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O3S82_RS07450	COG0363	glucosamine-6-phosphate deaminase activity
O3S82_RS07465	COG0166	Belongs to the GPI family
O3S82_RS07470	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
O3S82_RS07480	COG0109	protoheme IX farnesyltransferase activity
O3S82_RS07490	COG0456	acetyltransferase
O3S82_RS07490	COG0454	-acetyltransferase
O3S82_RS07495	COG1612	heme a metabolic process
O3S82_RS07510	COG1793	dna ligase
O3S82_RS07550	COG0396	ATPase activity
O3S82_RS07555	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O3S82_RS07560	COG0822	iron-sulfur transferase activity
O3S82_RS07565	COG2151	metal-sulfur cluster biosynthetic enzyme
O3S82_RS07575	COG0488	(ABC) transporter
O3S82_RS07590	COG3360	Dodecin
O3S82_RS07595	COG3830	Belongs to the UPF0237 family
O3S82_RS07595	COG0560	Phosphoserine phosphatase
O3S82_RS07600	COG1119	ATPase activity
O3S82_RS07620	COG1881	PFAM PEBP family protein
O3S82_RS07630	COG0242	peptide deformylase activity
O3S82_RS07640	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS07650	COG0545	Peptidyl-prolyl cis-trans isomerase
O3S82_RS07655	COG1643	Atp-dependent helicase
O3S82_RS07670	COG2733	membrane
O3S82_RS07725	COG0366	Alpha amylase catalytic
O3S82_RS07735	COG3281	Trehalose synthase
O3S82_RS07740	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
O3S82_RS07750	COG2226	methyltransferase
O3S82_RS07755	COG0798	PFAM Bile acid sodium symporter
O3S82_RS07780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O3S82_RS07805	COG1403	HNH endonuclease
O3S82_RS07845	COG1309	transcriptional regulator
O3S82_RS07860	COG0604	alcohol dehydrogenase
O3S82_RS07865	COG0791	NLP P60 protein
O3S82_RS07865	COG1388	LysM domain
O3S82_RS07900	COG0702	epimerase
O3S82_RS07910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O3S82_RS07915	COG0577	efflux transmembrane transporter activity
O3S82_RS07920	COG4585	Histidine kinase
O3S82_RS07925	COG2197	response regulator
O3S82_RS07945	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
O3S82_RS07950	COG0540	Belongs to the ATCase OTCase family
O3S82_RS07955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
O3S82_RS07960	COG0505	Belongs to the CarA family
O3S82_RS07965	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O3S82_RS07970	COG0284	orotidine-5'-phosphate decarboxylase activity
O3S82_RS08005	COG0194	GDP metabolic process
O3S82_RS08010	COG1758	RNA polymerase activity
O3S82_RS08020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
O3S82_RS08040	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
O3S82_RS08055	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O3S82_RS08055	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O3S82_RS08060	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
O3S82_RS08065	COG0140	phosphoribosyl-ATP diphosphatase activity
O3S82_RS08070	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
O3S82_RS08095	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
O3S82_RS08105	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
O3S82_RS08110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O3S82_RS08115	COG5002	protein histidine kinase activity
O3S82_RS08120	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
O3S82_RS08125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O3S82_RS08125	COG0072	phenylalanine-tRNA ligase activity
O3S82_RS08135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O3S82_RS08140	COG1403	HNH endonuclease
O3S82_RS08180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O3S82_RS08205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O3S82_RS08225	COG2153	protein acetylation
O3S82_RS08240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O3S82_RS08245	COG1121	(ABC) transporter
O3S82_RS08250	COG3443	Belongs to the bacterial solute-binding protein 9 family
O3S82_RS08250	COG0803	Belongs to the bacterial solute-binding protein 9 family
O3S82_RS08255	COG3842	ATPase activity
O3S82_RS08260	COG0363	glucosamine-6-phosphate deaminase activity
O3S82_RS08270	COG1472	Belongs to the glycosyl hydrolase 3 family
O3S82_RS08275	COG0395	ABC-type sugar transport system, permease component
O3S82_RS08280	COG1175	transmembrane transport
O3S82_RS08285	COG2182	Extracellular solute-binding protein
O3S82_RS08290	COG1940	carbohydrate kinase activity
O3S82_RS08295	COG0423	glycine-tRNA ligase activity
O3S82_RS08310	COG3402	PFAM membrane-flanked domain
O3S82_RS08320	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O3S82_RS08330	COG1196	nuclear chromosome segregation
O3S82_RS08335	COG0824	Thioesterase
O3S82_RS08340	COG1271	oxidase subunit
O3S82_RS08345	COG1294	oxidase, subunit
O3S82_RS08350	COG4988	ABC transporter
O3S82_RS08355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
O3S82_RS08375	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
O3S82_RS08385	COG3265	gluconokinase activity
O3S82_RS08405	COG1160	GTP binding
O3S82_RS08410	COG2066	Belongs to the glutaminase family
O3S82_RS08415	COG1403	HNH endonuclease
O3S82_RS08420	COG0039	L-malate dehydrogenase activity
O3S82_RS08450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
O3S82_RS08460	COG1131	(ABC) transporter
O3S82_RS08475	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
O3S82_RS08480	COG1492	cobalamin metabolic process
O3S82_RS08490	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
O3S82_RS08505	COG0406	alpha-ribazole phosphatase activity
O3S82_RS08510	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O3S82_RS08510	COG1648	precorrin-2 dehydrogenase activity
O3S82_RS08515	COG1797	cobyrinic acid a,c-diamide synthase activity
O3S82_RS08560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O3S82_RS08565	COG1120	ATPase activity
O3S82_RS08595	COG3467	pyridoxamine 5'-phosphate
O3S82_RS08600	COG0494	nUDIX hydrolase
O3S82_RS08615	COG0515	serine threonine protein kinase
O3S82_RS08620	COG0659	secondary active sulfate transmembrane transporter activity
O3S82_RS08640	COG0531	amino acid
O3S82_RS08650	COG0477	Major facilitator Superfamily
O3S82_RS08660	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
O3S82_RS08670	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
O3S82_RS08690	COG0628	permease
O3S82_RS08765	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
O3S82_RS08770	COG0697	spore germination
O3S82_RS08775	COG0739	heme binding
O3S82_RS08815	COG0509	glycine decarboxylation via glycine cleavage system
O3S82_RS08820	COG1716	ATPase activity
O3S82_RS08840	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O3S82_RS08840	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O3S82_RS08865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O3S82_RS08865	COG1648	precorrin-2 dehydrogenase activity
O3S82_RS08870	COG0175	sulfate reduction
O3S82_RS08880	COG0009	L-threonylcarbamoyladenylate synthase
O3S82_RS08905	COG1595	DNA-templated transcription, initiation
O3S82_RS08915	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
O3S82_RS08950	COG1028	Short-chain dehydrogenase reductase Sdr
O3S82_RS08950	COG0604	alcohol dehydrogenase
O3S82_RS08950	COG3321	synthase
O3S82_RS08970	COG2814	Major facilitator Superfamily
O3S82_RS08975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
O3S82_RS08980	COG3795	YCII-related domain
O3S82_RS08985	COG4941	Belongs to the sigma-70 factor family
O3S82_RS08990	COG2154	pterin-4-alpha-carbinolamine dehydratase
O3S82_RS08995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O3S82_RS09000	COG3655	Transcriptional regulator
O3S82_RS09010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O3S82_RS09040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O3S82_RS09060	COG0463	Glycosyl transferase, family 2
O3S82_RS09085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O3S82_RS09090	COG4581	dead DEAH box helicase
O3S82_RS09095	COG0805	protein transport
O3S82_RS09110	COG2378	regulation of single-species biofilm formation
O3S82_RS09120	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
O3S82_RS09130	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
O3S82_RS09135	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
O3S82_RS09145	COG4122	O-methyltransferase activity
O3S82_RS09155	COG1222	aaa ATPase
O3S82_RS09175	COG1994	Peptidase M50
O3S82_RS09175	COG0517	IMP dehydrogenase activity
O3S82_RS09180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O3S82_RS09185	COG0730	response to heat
O3S82_RS09190	COG2226	methyltransferase
O3S82_RS09200	COG0477	Major facilitator Superfamily
O3S82_RS09205	COG0646	methionine synthase
O3S82_RS09205	COG1410	methionine synthase
O3S82_RS09215	COG0215	cysteine-tRNA ligase activity
O3S82_RS09220	COG0598	Magnesium transport protein CorA
O3S82_RS09225	COG1968	undecaprenyl-diphosphatase activity
O3S82_RS09230	COG0667	Aldo Keto reductase
O3S82_RS09240	COG1295	ribonuclease BN
O3S82_RS09260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O3S82_RS09270	COG0542	response to heat
O3S82_RS09285	COG0697	spore germination
O3S82_RS09290	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
O3S82_RS09305	COG1403	HNH endonuclease
O3S82_RS09320	COG2837	iron assimilation
O3S82_RS09325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O3S82_RS09330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O3S82_RS09340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
O3S82_RS09345	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
O3S82_RS09350	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
O3S82_RS09360	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O3S82_RS09370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
O3S82_RS09375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O3S82_RS09395	COG2318	DinB family
O3S82_RS09400	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
O3S82_RS09405	COG0124	histidyl-tRNA synthetase
O3S82_RS09415	COG1196	nuclear chromosome segregation
O3S82_RS09420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O3S82_RS09425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O3S82_RS09445	COG0515	serine threonine protein kinase
O3S82_RS09450	COG2255	four-way junction helicase activity
O3S82_RS09455	COG0632	four-way junction helicase activity
O3S82_RS09460	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
O3S82_RS09470	COG0217	transcriptional regulatory protein
O3S82_RS09475	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
O3S82_RS09510	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
O3S82_RS09515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
O3S82_RS09525	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O3S82_RS09535	COG3835	regulator
O3S82_RS09550	COG0318	PFAM AMP-dependent synthetase and ligase
O3S82_RS09590	COG1215	transferase activity, transferring glycosyl groups
O3S82_RS09595	COG1366	Belongs to the anti-sigma-factor antagonist family
O3S82_RS09620	COG0135	phosphoribosylanthranilate isomerase activity
O3S82_RS09665	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O3S82_RS09695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
O3S82_RS09725	COG2326	polyphosphate kinase activity
O3S82_RS09740	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O3S82_RS09755	COG3253	May function as heme-dependent peroxidase
O3S82_RS09760	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
O3S82_RS09765	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
O3S82_RS09785	COG0667	Aldo Keto reductase
O3S82_RS09795	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O3S82_RS09825	COG0343	queuine tRNA-ribosyltransferase activity
O3S82_RS09835	COG0644	oxidoreductase
O3S82_RS09850	COG2814	Major facilitator Superfamily
O3S82_RS09855	COG1278	Cold shock
O3S82_RS09865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O3S82_RS09885	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O3S82_RS09910	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O3S82_RS09925	COG1074	ATP-dependent DNA helicase activity
O3S82_RS09930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
O3S82_RS09950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O3S82_RS09960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O3S82_RS09965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
O3S82_RS09975	COG0783	Belongs to the Dps family
O3S82_RS09990	COG1295	ribonuclease BN
O3S82_RS10000	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
O3S82_RS10020	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
O3S82_RS10025	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
O3S82_RS10030	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
O3S82_RS10040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
O3S82_RS10045	COG0159	tryptophan synthase activity
O3S82_RS10050	COG0133	tryptophan synthase activity
O3S82_RS10055	COG0134	indole-3-glycerol-phosphate synthase activity
O3S82_RS10070	COG2271	Major facilitator Superfamily
O3S82_RS10090	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
O3S82_RS10095	COG1132	(ABC) transporter
O3S82_RS10100	COG1132	(ABC) transporter
O3S82_RS10105	COG0107	imidazoleglycerol-phosphate synthase activity
O3S82_RS10120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
O3S82_RS10130	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
O3S82_RS10135	COG0131	Imidazoleglycerol-phosphate dehydratase
O3S82_RS10140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O3S82_RS10145	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
O3S82_RS10150	COG3135	benzoate transporter
O3S82_RS10165	COG0587	DNA-directed DNA polymerase activity
O3S82_RS10205	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
O3S82_RS10215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
O3S82_RS10220	COG3599	regulation of cell shape
O3S82_RS10230	COG1799	cell septum assembly
O3S82_RS10240	COG1496	oxidoreductase activity
O3S82_RS10245	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
O3S82_RS10250	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
O3S82_RS10255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O3S82_RS10260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O3S82_RS10270	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
O3S82_RS10275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O3S82_RS10280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
O3S82_RS10285	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
O3S82_RS10290	COG0768	penicillin binding
O3S82_RS10300	COG0275	rRNA processing
O3S82_RS10305	COG2001	Belongs to the MraZ family
O3S82_RS10335	COG0142	geranyltranstransferase activity
O3S82_RS10340	COG2815	serine threonine protein kinase
O3S82_RS10340	COG0515	serine threonine protein kinase
O3S82_RS10345	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
O3S82_RS10365	COG1940	carbohydrate kinase activity
O3S82_RS10375	COG1022	Amp-dependent synthetase and ligase
O3S82_RS10380	COG0791	NLP P60 protein
O3S82_RS10405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O3S82_RS10415	COG1845	cytochrome c oxidase, subunit III
O3S82_RS10420	COG2010	Cytochrome c
O3S82_RS10425	COG0723	plastoquinol--plastocyanin reductase activity
O3S82_RS10430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O3S82_RS10450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O3S82_RS10500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O3S82_RS10505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O3S82_RS10510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O3S82_RS10525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O3S82_RS10555	COG0501	Belongs to the peptidase M48B family
O3S82_RS10575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
O3S82_RS10580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O3S82_RS10595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O3S82_RS10600	COG0508	dehydrogenase complex catalyzes the overall conversion of
O3S82_RS10605	COG1090	epimerase
O3S82_RS10620	COG0321	lipoyl(octanoyl) transferase activity
O3S82_RS10625	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
O3S82_RS10685	COG0174	glutamine synthetase
O3S82_RS10695	COG0384	phenazine biosynthesis protein PhzF
O3S82_RS10700	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
O3S82_RS10710	COG0733	neurotransmitter:sodium symporter activity
O3S82_RS10735	COG0494	nUDIX hydrolase
O3S82_RS10745	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O3S82_RS10750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O3S82_RS10765	COG0352	thiamine-phosphate diphosphorylase activity
O3S82_RS10765	COG0351	phosphomethylpyrimidine kinase
O3S82_RS10765	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
O3S82_RS10770	COG0352	thiamine-phosphate diphosphorylase activity
O3S82_RS10775	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
O3S82_RS10785	COG2197	response regulator
O3S82_RS10825	COG2897	thiosulfate sulfurtransferase activity
O3S82_RS10830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O3S82_RS10835	COG0318	PFAM AMP-dependent synthetase and ligase
O3S82_RS10905	COG1024	Enoyl-CoA hydratase
O3S82_RS10915	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS10935	COG1309	transcriptional regulator
O3S82_RS10950	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O3S82_RS10955	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS10960	COG2357	RelA SpoT domain protein
O3S82_RS10995	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
O3S82_RS11005	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
O3S82_RS11005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O3S82_RS11015	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
O3S82_RS11020	COG0656	L-ascorbic acid biosynthetic process
O3S82_RS11045	COG2119	membrane
O3S82_RS11050	COG3022	response to hydroperoxide
O3S82_RS11070	COG0739	heme binding
O3S82_RS11070	COG0741	lytic transglycosylase activity
O3S82_RS11070	COG1196	nuclear chromosome segregation
O3S82_RS11120	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
O3S82_RS11180	COG0358	DNA primase activity
O3S82_RS11190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O3S82_RS11195	COG0571	ribonuclease III activity
O3S82_RS11200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
O3S82_RS11210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O3S82_RS11215	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
O3S82_RS11220	COG0742	ribosomal rna small subunit methyltransferase
O3S82_RS11230	COG1461	Dihydroxyacetone kinase
O3S82_RS11235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
O3S82_RS11240	COG0154	amidase activity
O3S82_RS11260	COG1181	Belongs to the D-alanine--D-alanine ligase family
O3S82_RS11265	COG0626	cystathionine gamma-synthase activity
O3S82_RS11270	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
O3S82_RS11280	COG0066	3-isopropylmalate dehydratase activity
O3S82_RS11285	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
O3S82_RS11290	COG1414	Transcriptional regulator
O3S82_RS11295	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O3S82_RS11315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O3S82_RS11330	COG0431	NADPH-dependent FMN reductase
O3S82_RS11335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O3S82_RS11340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O3S82_RS11345	COG1116	anion transmembrane transporter activity
O3S82_RS11370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O3S82_RS11375	COG1823	symporter activity
O3S82_RS11390	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
O3S82_RS11410	COG0318	PFAM AMP-dependent synthetase and ligase
O3S82_RS11420	COG0318	PFAM AMP-dependent synthetase and ligase
O3S82_RS11430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O3S82_RS11435	COG0179	Fumarylacetoacetate (FAA) hydrolase
O3S82_RS11450	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O3S82_RS11455	COG1381	Involved in DNA repair and RecF pathway recombination
O3S82_RS11465	COG1012	belongs to the aldehyde dehydrogenase family
O3S82_RS11480	COG0666	response to abiotic stimulus
O3S82_RS11490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O3S82_RS11495	COG0435	Glutathione S-transferase
O3S82_RS11510	COG0714	Associated with various cellular activities
O3S82_RS11520	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O3S82_RS11520	COG1796	DNA polymerase
O3S82_RS11530	COG0583	DNA-binding transcription factor activity
O3S82_RS11535	COG1403	HNH endonuclease
O3S82_RS11540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
O3S82_RS11555	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
O3S82_RS11565	COG0537	adenosine 5'-monophosphoramidase activity
O3S82_RS11570	COG0484	heat shock protein binding
O3S82_RS11575	COG1420	regulation of RNA biosynthetic process
O3S82_RS11595	COG2235	arginine
O3S82_RS11615	COG0481	GTPase activity
O3S82_RS11625	COG0268	Binds directly to 16S ribosomal RNA
O3S82_RS11635	COG0658	competence protein
O3S82_RS11635	COG2333	competence protein COMEC
O3S82_RS11640	COG1555	photosystem II stabilization
O3S82_RS11645	COG1307	EDD domain protein, DegV family
O3S82_RS11650	COG0243	molybdopterin cofactor binding
O3S82_RS11670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O3S82_RS11675	COG2223	nitrite transmembrane transporter activity
O3S82_RS11680	COG0495	leucyl-tRNA aminoacylation
O3S82_RS11685	COG0569	domain protein
O3S82_RS11690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O3S82_RS11705	COG1216	Glycosyl transferase, family 2
O3S82_RS11765	COG2197	response regulator
O3S82_RS11780	COG0069	glutamate synthase activity
O3S82_RS11825	COG1595	DNA-templated transcription, initiation
O3S82_RS11835	COG2273	Hydrolase Family 16
O3S82_RS11880	COG0778	Nitroreductase
O3S82_RS11890	COG2226	methyltransferase
O3S82_RS11905	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
O3S82_RS11910	COG0564	pseudouridine synthase activity
O3S82_RS11925	COG3590	peptidase
O3S82_RS11930	COG0477	Major facilitator Superfamily
O3S82_RS11935	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
O3S82_RS11950	COG1136	(ABC) transporter
O3S82_RS11950	COG0577	efflux transmembrane transporter activity
O3S82_RS11955	COG0577	efflux transmembrane transporter activity
O3S82_RS12000	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O3S82_RS12005	COG0254	rRNA binding
O3S82_RS12010	COG0227	Belongs to the bacterial ribosomal protein bL28 family
O3S82_RS12015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
O3S82_RS12020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
O3S82_RS12030	COG0406	alpha-ribazole phosphatase activity
O3S82_RS12035	COG0799	negative regulation of ribosome biogenesis
O3S82_RS12040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
O3S82_RS12050	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O3S82_RS12055	COG1289	transmembrane transporter activity
O3S82_RS12060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O3S82_RS12075	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
O3S82_RS12080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
O3S82_RS12085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
O3S82_RS12090	COG0261	This protein binds to 23S rRNA in the presence of protein L20
O3S82_RS12095	COG1530	ribonuclease E activity
O3S82_RS12110	COG2807	transmembrane transport
O3S82_RS12130	COG0745	RESPONSE REGULATOR receiver
O3S82_RS12135	COG2205	protein histidine kinase activity
O3S82_RS12140	COG1842	Phage shock protein A
O3S82_RS12190	COG0071	Belongs to the small heat shock protein (HSP20) family
O3S82_RS12195	COG0789	Transcriptional regulator
O3S82_RS12210	COG0653	protein targeting
O3S82_RS12215	COG3214	Protein conserved in bacteria
O3S82_RS12220	COG2197	response regulator
O3S82_RS12225	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
O3S82_RS12230	COG1040	competence protein
O3S82_RS12235	COG5401	PFAM Sporulation and spore germination
O3S82_RS12240	COG5002	protein histidine kinase activity
O3S82_RS12240	COG5000	phosphorelay sensor kinase activity
O3S82_RS12250	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
O3S82_RS12295	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
O3S82_RS12300	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
O3S82_RS12305	COG0657	acetylesterase activity
O3S82_RS12310	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
O3S82_RS12330	COG1254	Belongs to the acylphosphatase family
O3S82_RS12350	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O3S82_RS12370	COG0471	metal ion transport
O3S82_RS12390	COG1140	nitrate reductase beta subunit
O3S82_RS12400	COG0746	molybdenum cofactor guanylyltransferase activity
O3S82_RS12410	COG0303	'Molybdopterin
O3S82_RS12420	COG2301	Belongs to the HpcH HpaI aldolase family
O3S82_RS12435	COG4129	membrane
O3S82_RS12440	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
O3S82_RS12470	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
O3S82_RS12485	COG0277	FAD linked oxidase domain protein
O3S82_RS12490	COG2011	ABC-type metal ion transport system permease component
O3S82_RS12495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O3S82_RS12505	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
O3S82_RS12510	COG2171	N-acyltransferase activity
O3S82_RS12530	COG4214	carbohydrate transport
O3S82_RS12540	COG4213	ABC transporter substrate-binding protein
O3S82_RS12560	COG0456	acetyltransferase
O3S82_RS12565	COG2720	vancomycin resistance protein
O3S82_RS12575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O3S82_RS12590	COG1309	transcriptional regulator
O3S82_RS12600	COG0385	Bile acid
O3S82_RS12630	COG3012	SEC-C Motif Domain Protein
O3S82_RS12635	COG1742	UPF0060 membrane protein
O3S82_RS12640	COG1309	transcriptional regulator
O3S82_RS12700	COG0488	(ABC) transporter
O3S82_RS12730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
O3S82_RS12765	COG0012	GTP binding
O3S82_RS12775	COG2890	protein-(glutamine-N5) methyltransferase activity
O3S82_RS12790	COG1322	Protein conserved in bacteria
O3S82_RS12805	COG0405	Gamma-glutamyltransferase
O3S82_RS12810	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
O3S82_RS12815	COG1570	exodeoxyribonuclease VII activity
O3S82_RS12820	COG1722	exodeoxyribonuclease VII activity
O3S82_RS12840	COG0114	fumarate hydratase activity
O3S82_RS12860	COG0105	UTP biosynthetic process
O3S82_RS12865	COG0366	Alpha amylase catalytic
O3S82_RS12905	COG0285	dihydrofolate synthase activity
O3S82_RS12910	COG2409	Drug exporters of the RND superfamily
O3S82_RS12915	COG0494	nUDIX hydrolase
O3S82_RS12920	COG0525	valine-tRNA ligase activity
O3S82_RS12925	COG1349	DNA-binding transcription factor activity
O3S82_RS12930	COG3268	Saccharopine dehydrogenase
O3S82_RS12935	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
O3S82_RS12940	COG0740	serine-type endopeptidase activity
O3S82_RS12945	COG0740	serine-type endopeptidase activity
O3S82_RS12970	COG0544	peptidyl-prolyl cis-trans isomerase activity
O3S82_RS12985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O3S82_RS12995	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
O3S82_RS13030	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
O3S82_RS13035	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
O3S82_RS13045	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
O3S82_RS13050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O3S82_RS13060	COG1331	Highly conserved protein containing a thioredoxin domain
O3S82_RS13070	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
O3S82_RS13100	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O3S82_RS13110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O3S82_RS13115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
O3S82_RS13125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O3S82_RS13160	COG1674	ftsk spoiiie
O3S82_RS13265	COG0220	tRNA (guanine-N7-)-methyltransferase activity
O3S82_RS13300	COG0148	phosphopyruvate hydratase activity
O3S82_RS13325	COG1316	TRANSCRIPTIONal
O3S82_RS13335	COG0736	holo-[acyl-carrier-protein] synthase activity
O3S82_RS13350	COG0367	asparagine synthase
O3S82_RS13355	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
O3S82_RS13360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O3S82_RS13400	COG0438	transferase activity, transferring glycosyl groups
O3S82_RS13405	COG2244	polysaccharide biosynthetic process
O3S82_RS13440	COG0463	Glycosyl transferase, family 2
O3S82_RS13445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O3S82_RS13470	COG0193	aminoacyl-tRNA hydrolase activity
O3S82_RS13475	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
O3S82_RS13485	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
O3S82_RS13490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
O3S82_RS13510	COG0488	(ABC) transporter
O3S82_RS13515	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
O3S82_RS13520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
O3S82_RS13525	COG3583	domain protein
O3S82_RS13530	COG0084	hydrolase, TatD family'
O3S82_RS13535	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O3S82_RS13540	COG1132	(ABC) transporter
O3S82_RS13550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O3S82_RS13575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O3S82_RS13580	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O3S82_RS13585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O3S82_RS13620	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
O3S82_RS13630	COG1012	belongs to the aldehyde dehydrogenase family
O3S82_RS13640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O3S82_RS13645	COG0516	GMP reductase activity
O3S82_RS13675	COG0459	protein refolding
O3S82_RS13680	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
O3S82_RS13690	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
O3S82_RS13695	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
O3S82_RS13700	COG1984	allophanate hydrolase subunit 2
O3S82_RS13705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
O3S82_RS13725	COG0456	acetyltransferase
O3S82_RS13725	COG0454	-acetyltransferase
O3S82_RS13730	COG0456	acetyltransferase
O3S82_RS13730	COG1214	PFAM Peptidase M22, glycoprotease
O3S82_RS13735	COG0802	atpase or kinase
O3S82_RS13745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O3S82_RS13750	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
O3S82_RS13750	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
O3S82_RS13755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O3S82_RS13760	COG1072	(Pantothenic acid kinase))
O3S82_RS13770	COG0454	-acetyltransferase
O3S82_RS13775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O3S82_RS13780	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O3S82_RS13785	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
O3S82_RS13800	COG1946	Acyl-CoA thioesterase
O3S82_RS13840	COG0318	PFAM AMP-dependent synthetase and ligase
O3S82_RS13850	COG1028	Short-chain dehydrogenase reductase Sdr
O3S82_RS13860	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS13900	COG1024	Enoyl-CoA hydratase
O3S82_RS13915	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
O3S82_RS13920	COG2070	2-Nitropropane dioxygenase
O3S82_RS13930	COG0183	Belongs to the thiolase family
O3S82_RS13940	COG0183	Belongs to the thiolase family
O3S82_RS13955	COG0318	PFAM AMP-dependent synthetase and ligase
O3S82_RS13975	COG0101	tRNA pseudouridine synthase activity
O3S82_RS13990	COG2813	Specifically methylates the guanine in position
O3S82_RS13995	COG0439	Biotin carboxylase
O3S82_RS14000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O3S82_RS14020	COG0747	negative chemotaxis
O3S82_RS14025	COG0318	PFAM AMP-dependent synthetase and ligase
O3S82_RS14035	COG0511	ligase activity, forming carbon-carbon bonds
O3S82_RS14045	COG0318	PFAM AMP-dependent synthetase and ligase
O3S82_RS14060	COG1309	transcriptional regulator
O3S82_RS14095	COG1793	dna ligase
O3S82_RS14110	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS14115	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS14125	COG1309	transcriptional regulator
O3S82_RS14135	COG1024	Enoyl-CoA hydratase
O3S82_RS14140	COG0183	Belongs to the thiolase family
O3S82_RS14160	COG1024	Enoyl-CoA hydratase
O3S82_RS14180	COG0318	PFAM AMP-dependent synthetase and ligase
O3S82_RS14190	COG0444	Belongs to the ABC transporter superfamily
O3S82_RS14195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O3S82_RS14220	COG0318	PFAM AMP-dependent synthetase and ligase
O3S82_RS14240	COG1404	Belongs to the peptidase S8 family
O3S82_RS14245	COG0203	ribosomal protein L17
O3S82_RS14250	COG0202	RNA polymerase activity
O3S82_RS14255	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
O3S82_RS14260	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
O3S82_RS14265	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
O3S82_RS14270	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O3S82_RS14275	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
O3S82_RS14285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O3S82_RS14300	COG1834	amidinotransferase
O3S82_RS14325	COG0563	adenylate kinase activity
O3S82_RS14340	COG1841	ribosomal large subunit assembly
O3S82_RS14345	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
O3S82_RS14350	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
O3S82_RS14355	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
O3S82_RS14360	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
O3S82_RS14365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
O3S82_RS14370	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
O3S82_RS14375	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
O3S82_RS14380	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
O3S82_RS14385	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
O3S82_RS14395	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
O3S82_RS14400	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
O3S82_RS14405	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
O3S82_RS14410	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
O3S82_RS14415	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
O3S82_RS14420	COG0089	rRNA binding
O3S82_RS14425	COG0088	Forms part of the polypeptide exit tunnel
O3S82_RS14430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
O3S82_RS14435	COG0051	transcription antitermination factor activity, RNA binding
O3S82_RS14445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O3S82_RS14450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O3S82_RS14455	COG0049	tRNA binding
O3S82_RS14460	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
O3S82_RS14470	COG0247	lactate metabolic process
O3S82_RS14470	COG0277	FAD linked oxidase domain protein
O3S82_RS14475	COG1802	Transcriptional regulator
O3S82_RS14485	COG3594	Acyltransferase
O3S82_RS14490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
O3S82_RS14495	COG0085	RNA polymerase activity
O3S82_RS14500	COG0222	ribosome binding
O3S82_RS14515	COG0081	regulation of translation
O3S82_RS14520	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
O3S82_RS14530	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O3S82_RS14540	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
O3S82_RS14550	COG0812	UDP-N-acetylmuramate dehydrogenase activity
O3S82_RS14555	COG0267	Belongs to the bacterial ribosomal protein bL33 family
O3S82_RS14570	COG0167	dihydroorotate dehydrogenase activity
O3S82_RS14585	COG0463	Glycosyl transferase, family 2
O3S82_RS14600	COG1666	GTP binding
O3S82_RS14615	COG0142	geranyltranstransferase activity
O3S82_RS14620	COG1007	ATP synthesis coupled electron transport
O3S82_RS14630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O3S82_RS14635	COG0713	ATP synthesis coupled electron transport
O3S82_RS14645	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O3S82_RS14650	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
O3S82_RS14655	COG1034	ATP synthesis coupled electron transport
O3S82_RS14660	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
O3S82_RS14670	COG0649	NAD binding
O3S82_RS14675	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O3S82_RS14680	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O3S82_RS14690	COG2226	methyltransferase
O3S82_RS14735	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
O3S82_RS14740	COG4948	Mandelate Racemase Muconate Lactonizing
O3S82_RS14745	COG0702	epimerase
O3S82_RS14780	COG1131	(ABC) transporter
O3S82_RS14785	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O3S82_RS14795	COG0785	Cytochrome C biogenesis protein
O3S82_RS14800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O3S82_RS14805	COG0406	alpha-ribazole phosphatase activity
O3S82_RS14810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O3S82_RS14820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O3S82_RS14820	COG1648	precorrin-2 dehydrogenase activity
O3S82_RS14825	COG0181	hydroxymethylbilane synthase activity
O3S82_RS14830	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
O3S82_RS14835	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
O3S82_RS14840	COG2755	lipolytic protein G-D-S-L family
O3S82_RS14840	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
O3S82_RS14855	COG0318	PFAM AMP-dependent synthetase and ligase
O3S82_RS14870	COG2409	Drug exporters of the RND superfamily
O3S82_RS14910	COG0123	including yeast histone deacetylase and acetoin utilization protein
O3S82_RS14915	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O3S82_RS14920	COG1611	Belongs to the LOG family
O3S82_RS14935	COG1082	Xylose isomerase domain protein TIM barrel
O3S82_RS14940	COG0248	Ppx GppA phosphatase
O3S82_RS14960	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
O3S82_RS14965	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
O3S82_RS14980	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
O3S82_RS15015	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
O3S82_RS15025	COG0584	glycerophosphoryl diester phosphodiesterase
O3S82_RS15030	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
O3S82_RS15035	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
O3S82_RS15040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
O3S82_RS15045	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
O3S82_RS15060	COG1309	transcriptional regulator
O3S82_RS15070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O3S82_RS15085	COG1132	(ABC) transporter
O3S82_RS15090	COG2130	NADP-dependent
O3S82_RS15135	COG0596	Alpha beta hydrolase
O3S82_RS15155	COG2111	Na H antiporter
O3S82_RS15155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O3S82_RS15160	COG1006	Multisubunit Na H antiporter MnhC subunit
O3S82_RS15165	COG0651	ATP synthesis coupled electron transport
O3S82_RS15175	COG2212	antiporter activity
O3S82_RS15180	COG1320	monovalent cation:proton antiporter activity
O3S82_RS15190	COG0708	Exodeoxyribonuclease III
O3S82_RS15195	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O3S82_RS15230	COG0604	alcohol dehydrogenase
O3S82_RS15240	COG0702	epimerase
O3S82_RS15260	COG1028	Short-chain dehydrogenase reductase Sdr
O3S82_RS15265	COG0251	oxidation-reduction process
O3S82_RS15270	COG1902	pentaerythritol trinitrate reductase activity
O3S82_RS15270	COG0446	pyridine nucleotide-disulphide oxidoreductase
O3S82_RS15310	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
O3S82_RS15315	COG2508	Transcriptional regulator
O3S82_RS15335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O3S82_RS15365	COG1280	lysine exporter protein (LysE YggA)
O3S82_RS15370	COG0477	Major facilitator Superfamily
O3S82_RS15380	COG1217	gtp-binding protein TYPA
O3S82_RS15430	COG0354	folic acid binding
O3S82_RS15435	COG4044	May play a role in the intracellular transport of hydrophobic ligands
O3S82_RS15440	COG1490	D-aminoacyl-tRNA deacylase activity
O3S82_RS15445	COG1316	TRANSCRIPTIONal
O3S82_RS15450	COG1832	CoA-binding protein
O3S82_RS15465	COG0745	RESPONSE REGULATOR receiver
O3S82_RS15510	COG0745	RESPONSE REGULATOR receiver
O3S82_RS15530	COG2149	membrane
O3S82_RS15545	COG0454	-acetyltransferase
O3S82_RS15545	COG0456	acetyltransferase
O3S82_RS15550	COG0657	acetylesterase activity
O3S82_RS15560	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
O3S82_RS15585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O3S82_RS15590	COG0306	phosphate transporter
O3S82_RS15605	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O3S82_RS15605	COG0047	phosphoribosylformylglycinamidine synthase activity
O3S82_RS15610	COG1131	(ABC) transporter
O3S82_RS15630	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O3S82_RS15645	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O3S82_RS15650	COG0318	PFAM AMP-dependent synthetase and ligase
O3S82_RS15665	COG0515	serine threonine protein kinase
O3S82_RS15665	COG2815	serine threonine protein kinase
O3S82_RS15670	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
O3S82_RS15685	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O3S82_RS15695	COG0151	Belongs to the GarS family
O3S82_RS15720	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
O3S82_RS15735	COG1597	lipid kinase activity
O3S82_RS15790	COG0287	Prephenate dehydrogenase
O3S82_RS15790	COG1605	Chorismate mutase
O3S82_RS15795	COG0596	Alpha beta hydrolase
O3S82_RS15800	COG0470	DNA polymerase III
O3S82_RS15805	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
O3S82_RS15820	COG1754	DNA topoisomerase type I activity
O3S82_RS15820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O3S82_RS15830	COG2890	protein-(glutamine-N5) methyltransferase activity
O3S82_RS15835	COG1366	Belongs to the anti-sigma-factor antagonist family
O3S82_RS15840	COG1111	helicase
O3S82_RS15840	COG1205	dead DEAH box helicase
O3S82_RS15845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O3S82_RS15905	COG3275	phosphorelay sensor kinase activity
O3S82_RS15935	COG1122	ATPase activity
O3S82_RS15940	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
O3S82_RS15955	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O3S82_RS15970	COG0604	alcohol dehydrogenase
O3S82_RS15975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O3S82_RS16040	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
O3S82_RS16060	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
O3S82_RS16065	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
O3S82_RS16075	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
O3S82_RS16080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
O3S82_RS16090	COG0590	tRNA wobble adenosine to inosine editing
O3S82_RS16140	COG1920	GTP binding
O3S82_RS16145	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
O3S82_RS16155	COG2072	flavoprotein involved in K transport
O3S82_RS16160	COG0318	PFAM AMP-dependent synthetase and ligase
O3S82_RS16165	COG1024	Enoyl-CoA hydratase
O3S82_RS16170	COG0183	Belongs to the thiolase family
O3S82_RS16180	COG1028	Short-chain dehydrogenase reductase Sdr
O3S82_RS16190	COG1028	Short-chain dehydrogenase reductase Sdr
O3S82_RS16195	COG1028	Short-chain dehydrogenase reductase Sdr
O3S82_RS16250	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS16255	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS16260	COG1024	Enoyl-CoA hydratase
O3S82_RS16275	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS16280	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS16300	COG2318	DinB family
O3S82_RS16305	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
O3S82_RS16310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O3S82_RS16350	COG0433	COG0433 Predicted ATPase
O3S82_RS16365	COG0745	RESPONSE REGULATOR receiver
O3S82_RS16370	COG2205	protein histidine kinase activity
O3S82_RS16390	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS16395	COG1960	acyl-CoA dehydrogenase activity
O3S82_RS16435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
O3S82_RS16450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O3S82_RS16460	COG1408	metallophosphoesterase
O3S82_RS16465	COG2197	response regulator
O3S82_RS16470	COG4585	Histidine kinase
O3S82_RS16475	COG1131	(ABC) transporter
O3S82_RS16490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O3S82_RS16565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O3S82_RS16570	COG0561	phosphatase activity
O3S82_RS16575	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
O3S82_RS16580	COG1597	lipid kinase activity
O3S82_RS16605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O3S82_RS16615	COG0776	regulation of translation
O3S82_RS16620	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
O3S82_RS16645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O3S82_RS16650	COG1309	transcriptional regulator
O3S82_RS16670	COG0477	Major facilitator Superfamily
O3S82_RS16680	COG1739	Uncharacterized protein family UPF0029
O3S82_RS16690	COG1024	Enoyl-CoA hydratase
O3S82_RS16720	COG1716	ATPase activity
O3S82_RS16740	COG0515	serine threonine protein kinase
O3S82_RS16755	COG0705	Rhomboid family
O3S82_RS16765	COG1024	Enoyl-CoA hydratase
O3S82_RS16780	COG1476	TRANSCRIPTIONal
O3S82_RS16795	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O3S82_RS16800	COG4166	transmembrane transport
O3S82_RS16805	COG0601	transmembrane transport
O3S82_RS16850	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
O3S82_RS16855	COG0142	geranyltranstransferase activity
O3S82_RS16885	COG1216	Glycosyl transferase, family 2
O3S82_RS16910	COG0494	nUDIX hydrolase
O3S82_RS16945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O3S82_RS16960	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
O3S82_RS16965	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
O3S82_RS16970	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
O3S82_RS16975	COG0592	DNA-directed DNA polymerase activity
O3S82_RS16980	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O3S82_RS16985	COG0230	Belongs to the bacterial ribosomal protein bL34 family
O3S82_RS16990	COG0594	ribonuclease P activity
O3S82_RS16995	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
O3S82_RS17000	COG0706	membrane insertase activity
O3S82_RS17010	COG0357	Ribosomal RNA small subunit methyltransferase G
O3S82_RS17015	COG1192	Involved in chromosome partitioning
O3S82_RS17025	COG3118	belongs to the thioredoxin family
O3S82_RS17030	COG0492	ferredoxin-NADP+ reductase activity
O3S82_RS17035	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O3S82_RS17035	COG0515	serine threonine protein kinase
O3S82_RS17055	COG0488	(ABC) transporter
O3S82_RS17075	COG1022	Amp-dependent synthetase and ligase
O3S82_RS17085	COG0410	ABC transporter
O3S82_RS17105	COG2354	Protein conserved in bacteria
O3S82_RS17110	COG1280	lysine exporter protein (LysE YggA)
O3S82_RS17115	COG1260	myo-inositol-1-phosphate synthase
O3S82_RS17120	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
O3S82_RS17125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O3S82_RS17175	COG0667	Aldo Keto reductase
O3S82_RS17180	COG0577	efflux transmembrane transporter activity
O3S82_RS17180	COG1136	(ABC) transporter
O3S82_RS17185	COG0577	efflux transmembrane transporter activity
O3S82_RS17185	COG1136	(ABC) transporter
O3S82_RS17190	COG0360	Binds together with S18 to 16S ribosomal RNA
O3S82_RS17200	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
O3S82_RS17205	COG0359	binds to the 23S rRNA
O3S82_RS17215	COG2375	cellular response to nickel ion
O3S82_RS17230	COG0305	Participates in initiation and elongation during chromosome replication
O3S82_RS17275	COG0483	inositol monophosphate 1-phosphatase activity
O3S82_RS17290	COG4585	Histidine kinase
O3S82_RS17300	COG0572	uridine kinase