locus-tag	class	description
H9L21_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H9L21_RS00010	COG0592	DNA-directed DNA polymerase activity
H9L21_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H9L21_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H9L21_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
H9L21_RS00045	COG4213	ABC transporter substrate-binding protein
H9L21_RS00050	COG1349	DNA-binding transcription factor activity
H9L21_RS00070	COG0406	alpha-ribazole phosphatase activity
H9L21_RS00075	COG0187	DNA topoisomerase II activity
H9L21_RS00080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H9L21_RS00110	COG1216	Glycosyl transferase, family 2
H9L21_RS00130	COG1233	COG1233 Phytoene dehydrogenase and related
H9L21_RS00140	COG0142	geranyltranstransferase activity
H9L21_RS00170	COG0589	response to stress
H9L21_RS00195	COG0601	transmembrane transport
H9L21_RS00200	COG4166	transmembrane transport
H9L21_RS00205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9L21_RS00220	COG1476	TRANSCRIPTIONal
H9L21_RS00235	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9L21_RS00240	COG0705	Rhomboid family
H9L21_RS00275	COG1716	ATPase activity
H9L21_RS00310	COG1024	Enoyl-CoA hydratase
H9L21_RS00320	COG1739	Uncharacterized protein family UPF0029
H9L21_RS00330	COG0477	Major facilitator Superfamily
H9L21_RS00345	COG0697	spore germination
H9L21_RS00355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9L21_RS00380	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H9L21_RS00385	COG0776	regulation of translation
H9L21_RS00395	COG2409	Drug exporters of the RND superfamily
H9L21_RS00400	COG1309	transcriptional regulator
H9L21_RS00430	COG1597	lipid kinase activity
H9L21_RS00435	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H9L21_RS00440	COG0561	phosphatase activity
H9L21_RS00445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9L21_RS00465	COG0494	nUDIX hydrolase
H9L21_RS00515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9L21_RS00530	COG1131	(ABC) transporter
H9L21_RS00535	COG4585	Histidine kinase
H9L21_RS00540	COG2197	response regulator
H9L21_RS00545	COG1408	metallophosphoesterase
H9L21_RS00555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9L21_RS00570	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H9L21_RS00575	COG2076	Multidrug Resistance protein
H9L21_RS00620	COG1960	acyl-CoA dehydrogenase activity
H9L21_RS00625	COG1960	acyl-CoA dehydrogenase activity
H9L21_RS00630	COG0095	Lipoate-protein ligase
H9L21_RS00645	COG2205	protein histidine kinase activity
H9L21_RS00650	COG0745	RESPONSE REGULATOR receiver
H9L21_RS00675	COG3263	regulation of cellular component size
H9L21_RS00690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9L21_RS00720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9L21_RS00725	COG0590	tRNA wobble adenosine to inosine editing
H9L21_RS00735	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H9L21_RS00740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H9L21_RS00745	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H9L21_RS00750	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H9L21_RS00770	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H9L21_RS00845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9L21_RS00850	COG1028	Short-chain dehydrogenase reductase Sdr
H9L21_RS00850	COG3321	synthase
H9L21_RS00850	COG0604	alcohol dehydrogenase
H9L21_RS00865	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9L21_RS00885	COG1122	ATPase activity
H9L21_RS00910	COG3275	phosphorelay sensor kinase activity
H9L21_RS00970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9L21_RS00975	COG1111	helicase
H9L21_RS00975	COG1205	dead DEAH box helicase
H9L21_RS00980	COG1366	Belongs to the anti-sigma-factor antagonist family
H9L21_RS00985	COG2890	protein-(glutamine-N5) methyltransferase activity
H9L21_RS00995	COG1754	DNA topoisomerase type I activity
H9L21_RS00995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H9L21_RS01005	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H9L21_RS01010	COG0470	DNA polymerase III
H9L21_RS01015	COG0596	Alpha beta hydrolase
H9L21_RS01020	COG1605	Chorismate mutase
H9L21_RS01020	COG0287	Prephenate dehydrogenase
H9L21_RS01070	COG1002	Type II restriction enzyme, methylase subunits
H9L21_RS01140	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H9L21_RS01175	COG0151	Belongs to the GarS family
H9L21_RS01185	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H9L21_RS01195	COG0463	Glycosyl transferase, family 2
H9L21_RS01205	COG0463	Glycosyl transferase, family 2
H9L21_RS01225	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H9L21_RS01230	COG0318	PFAM AMP-dependent synthetase and ligase
H9L21_RS01260	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H9L21_RS01285	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H9L21_RS01285	COG0047	phosphoribosylformylglycinamidine synthase activity
H9L21_RS01300	COG0306	phosphate transporter
H9L21_RS01305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H9L21_RS01330	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H9L21_RS01340	COG0657	acetylesterase activity
H9L21_RS01345	COG0456	acetyltransferase
H9L21_RS01375	COG0745	RESPONSE REGULATOR receiver
H9L21_RS01405	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H9L21_RS01410	COG1832	CoA-binding protein
H9L21_RS01420	COG1490	D-aminoacyl-tRNA deacylase activity
H9L21_RS01425	COG4044	May play a role in the intracellular transport of hydrophobic ligands
H9L21_RS01430	COG0354	folic acid binding
H9L21_RS01480	COG1217	gtp-binding protein TYPA
H9L21_RS01490	COG0477	Major facilitator Superfamily
H9L21_RS01495	COG1280	lysine exporter protein (LysE YggA)
H9L21_RS01520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9L21_RS01525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9L21_RS01550	COG1741	Belongs to the pirin family
H9L21_RS01560	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H9L21_RS01565	COG0708	Exodeoxyribonuclease III
H9L21_RS01570	COG1320	monovalent cation:proton antiporter activity
H9L21_RS01575	COG2212	antiporter activity
H9L21_RS01585	COG0651	ATP synthesis coupled electron transport
H9L21_RS01590	COG1006	Multisubunit Na H antiporter MnhC subunit
H9L21_RS01595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H9L21_RS01595	COG2111	Na H antiporter
H9L21_RS01615	COG0596	Alpha beta hydrolase
H9L21_RS01665	COG2130	NADP-dependent
H9L21_RS01670	COG0456	acetyltransferase
H9L21_RS01680	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H9L21_RS01690	COG1309	transcriptional regulator
H9L21_RS01710	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H9L21_RS01715	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H9L21_RS01720	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H9L21_RS01730	COG0477	Major facilitator Superfamily
H9L21_RS01745	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H9L21_RS01785	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H9L21_RS01800	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
H9L21_RS01805	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H9L21_RS01825	COG0248	Ppx GppA phosphatase
H9L21_RS01830	COG1082	Xylose isomerase domain protein TIM barrel
H9L21_RS01855	COG0123	including yeast histone deacetylase and acetoin utilization protein
H9L21_RS01895	COG2409	Drug exporters of the RND superfamily
H9L21_RS01910	COG0318	PFAM AMP-dependent synthetase and ligase
H9L21_RS01925	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H9L21_RS01925	COG2755	lipolytic protein G-D-S-L family
H9L21_RS01930	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
H9L21_RS01935	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H9L21_RS01945	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H9L21_RS01945	COG1648	precorrin-2 dehydrogenase activity
H9L21_RS01950	COG0113	porphobilinogen synthase activity
H9L21_RS01955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H9L21_RS01960	COG0406	alpha-ribazole phosphatase activity
H9L21_RS01965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L21_RS01970	COG0785	Cytochrome C biogenesis protein
H9L21_RS01980	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9L21_RS01995	COG0842	Transport permease protein
H9L21_RS02025	COG0702	epimerase
H9L21_RS02030	COG4948	Mandelate Racemase Muconate Lactonizing
H9L21_RS02035	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H9L21_RS02070	COG2226	methyltransferase
H9L21_RS02080	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9L21_RS02085	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9L21_RS02090	COG0649	NAD binding
H9L21_RS02100	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H9L21_RS02105	COG1034	ATP synthesis coupled electron transport
H9L21_RS02110	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H9L21_RS02115	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9L21_RS02130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H9L21_RS02140	COG1007	ATP synthesis coupled electron transport
H9L21_RS02145	COG0142	geranyltranstransferase activity
H9L21_RS02150	COG3177	Filamentation induced by cAMP protein fic
H9L21_RS02165	COG1666	GTP binding
H9L21_RS02180	COG0463	Glycosyl transferase, family 2
H9L21_RS02185	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H9L21_RS02195	COG0167	dihydroorotate dehydrogenase activity
H9L21_RS02210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H9L21_RS02215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H9L21_RS02225	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H9L21_RS02235	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H9L21_RS02245	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H9L21_RS02250	COG0081	regulation of translation
H9L21_RS02265	COG0222	ribosome binding
H9L21_RS02275	COG0085	RNA polymerase activity
H9L21_RS02280	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H9L21_RS02285	COG3594	Acyltransferase
H9L21_RS02300	COG1802	Transcriptional regulator
H9L21_RS02305	COG0277	FAD linked oxidase domain protein
H9L21_RS02305	COG0247	lactate metabolic process
H9L21_RS02315	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H9L21_RS02320	COG0049	tRNA binding
H9L21_RS02325	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9L21_RS02330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H9L21_RS02340	COG0051	transcription antitermination factor activity, RNA binding
H9L21_RS02345	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H9L21_RS02350	COG0088	Forms part of the polypeptide exit tunnel
H9L21_RS02355	COG0089	rRNA binding
H9L21_RS02360	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H9L21_RS02365	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H9L21_RS02370	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H9L21_RS02375	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H9L21_RS02380	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H9L21_RS02385	COG0255	Belongs to the universal ribosomal protein uL29 family
H9L21_RS02390	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H9L21_RS02395	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H9L21_RS02400	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H9L21_RS02405	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H9L21_RS02410	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H9L21_RS02415	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H9L21_RS02420	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H9L21_RS02425	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H9L21_RS02430	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H9L21_RS02435	COG1841	ribosomal large subunit assembly
H9L21_RS02450	COG0563	adenylate kinase activity
H9L21_RS02465	COG1834	amidinotransferase
H9L21_RS02480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9L21_RS02490	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H9L21_RS02495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H9L21_RS02500	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H9L21_RS02505	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H9L21_RS02510	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H9L21_RS02515	COG0202	RNA polymerase activity
H9L21_RS02520	COG0203	ribosomal protein L17
H9L21_RS02525	COG1404	Belongs to the peptidase S8 family
H9L21_RS02530	COG1404	Belongs to the peptidase S8 family
H9L21_RS02545	COG0318	PFAM AMP-dependent synthetase and ligase
H9L21_RS02570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9L21_RS02575	COG0444	Belongs to the ABC transporter superfamily
H9L21_RS02585	COG0318	PFAM AMP-dependent synthetase and ligase
H9L21_RS02605	COG1024	Enoyl-CoA hydratase
H9L21_RS02625	COG0183	Belongs to the thiolase family
H9L21_RS02630	COG1024	Enoyl-CoA hydratase
H9L21_RS02640	COG1309	transcriptional regulator
H9L21_RS02650	COG1960	acyl-CoA dehydrogenase activity
H9L21_RS02655	COG1960	acyl-CoA dehydrogenase activity
H9L21_RS02670	COG1793	dna ligase
H9L21_RS02680	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H9L21_RS02685	COG1309	transcriptional regulator
H9L21_RS02695	COG0318	PFAM AMP-dependent synthetase and ligase
H9L21_RS02705	COG0511	ligase activity, forming carbon-carbon bonds
H9L21_RS02715	COG0318	PFAM AMP-dependent synthetase and ligase
H9L21_RS02720	COG0747	negative chemotaxis
H9L21_RS02740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9L21_RS02745	COG0439	Biotin carboxylase
H9L21_RS02750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9L21_RS02760	COG1051	belongs to the nudix hydrolase family
H9L21_RS02765	COG0101	tRNA pseudouridine synthase activity
H9L21_RS02780	COG0183	Belongs to the thiolase family
H9L21_RS02790	COG0183	Belongs to the thiolase family
H9L21_RS02800	COG2070	2-Nitropropane dioxygenase
H9L21_RS02820	COG1024	Enoyl-CoA hydratase
H9L21_RS02825	COG1619	proteins homologs of microcin C7 resistance protein MccF
H9L21_RS02860	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
H9L21_RS02870	COG0318	PFAM AMP-dependent synthetase and ligase
H9L21_RS02875	COG0300	oxidoreductase activity
H9L21_RS02910	COG1946	Acyl-CoA thioesterase
H9L21_RS02925	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H9L21_RS02930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H9L21_RS02935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9L21_RS02950	COG1072	(Pantothenic acid kinase))
H9L21_RS02955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H9L21_RS02960	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H9L21_RS02960	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H9L21_RS02965	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9L21_RS02975	COG0802	atpase or kinase
H9L21_RS02980	COG0456	acetyltransferase
H9L21_RS02980	COG1214	PFAM Peptidase M22, glycoprotease
H9L21_RS03005	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H9L21_RS03015	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H9L21_RS03020	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H9L21_RS03040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H9L21_RS03045	COG0459	protein refolding
H9L21_RS03075	COG0516	GMP reductase activity
H9L21_RS03080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9L21_RS03090	COG1012	belongs to the aldehyde dehydrogenase family
H9L21_RS03105	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H9L21_RS03135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H9L21_RS03140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H9L21_RS03155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9L21_RS03180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9L21_RS03185	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9L21_RS03190	COG0084	hydrolase, TatD family'
H9L21_RS03195	COG3583	domain protein
H9L21_RS03200	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H9L21_RS03205	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H9L21_RS03210	COG0488	(ABC) transporter
H9L21_RS03215	COG1846	Transcriptional regulator
H9L21_RS03225	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H9L21_RS03230	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H9L21_RS03240	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H9L21_RS03245	COG0193	aminoacyl-tRNA hydrolase activity
H9L21_RS03270	COG0489	protein tyrosine kinase activity
H9L21_RS03275	COG3420	alginic acid biosynthetic process
H9L21_RS03345	COG1316	TRANSCRIPTIONal
H9L21_RS03370	COG0148	phosphopyruvate hydratase activity
H9L21_RS03405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H9L21_RS03460	COG3663	DNA glycosylase
H9L21_RS03465	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9L21_RS03475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H9L21_RS03480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9L21_RS03490	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H9L21_RS03530	COG1331	Highly conserved protein containing a thioredoxin domain
H9L21_RS03540	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H9L21_RS03545	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H9L21_RS03555	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H9L21_RS03560	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H9L21_RS03605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H9L21_RS03620	COG0544	peptidyl-prolyl cis-trans isomerase activity
H9L21_RS03645	COG0740	serine-type endopeptidase activity
H9L21_RS03650	COG0740	serine-type endopeptidase activity
H9L21_RS03655	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H9L21_RS03660	COG3268	Saccharopine dehydrogenase
H9L21_RS03665	COG1349	DNA-binding transcription factor activity
H9L21_RS03670	COG0525	valine-tRNA ligase activity
H9L21_RS03675	COG0494	nUDIX hydrolase
H9L21_RS03680	COG2409	Drug exporters of the RND superfamily
H9L21_RS03685	COG0285	dihydrofolate synthase activity
H9L21_RS03725	COG0366	Alpha amylase catalytic
H9L21_RS03730	COG0105	UTP biosynthetic process
H9L21_RS03750	COG0114	fumarate hydratase activity
H9L21_RS03770	COG1722	exodeoxyribonuclease VII activity
H9L21_RS03775	COG1570	exodeoxyribonuclease VII activity
H9L21_RS03780	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H9L21_RS03785	COG0405	Gamma-glutamyltransferase
H9L21_RS03800	COG1322	Protein conserved in bacteria
H9L21_RS03815	COG2890	protein-(glutamine-N5) methyltransferase activity
H9L21_RS03825	COG0012	GTP binding
H9L21_RS03830	COG0488	(ABC) transporter
H9L21_RS03855	COG1487	ribonuclease activity
H9L21_RS03885	COG1309	transcriptional regulator
H9L21_RS03895	COG0596	Alpha beta hydrolase
H9L21_RS03915	COG2376	Dihydroxyacetone kinase
H9L21_RS03935	COG1309	transcriptional regulator
H9L21_RS03940	COG1742	UPF0060 membrane protein
H9L21_RS03945	COG3012	SEC-C Motif Domain Protein
H9L21_RS03975	COG0385	Bile acid
H9L21_RS03985	COG1309	transcriptional regulator
H9L21_RS04000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H9L21_RS04015	COG0456	acetyltransferase
H9L21_RS04035	COG4213	ABC transporter substrate-binding protein
H9L21_RS04045	COG4214	carbohydrate transport
H9L21_RS04065	COG2171	N-acyltransferase activity
H9L21_RS04070	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H9L21_RS04075	COG1464	Belongs to the NlpA lipoprotein family
H9L21_RS04080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H9L21_RS04085	COG2011	ABC-type metal ion transport system permease component
H9L21_RS04145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H9L21_RS04165	COG2301	Belongs to the HpcH HpaI aldolase family
H9L21_RS04175	COG0303	'Molybdopterin
H9L21_RS04185	COG0746	molybdenum cofactor guanylyltransferase activity
H9L21_RS04195	COG1140	nitrate reductase beta subunit
H9L21_RS04215	COG0471	metal ion transport
H9L21_RS04235	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9L21_RS04255	COG1254	Belongs to the acylphosphatase family
H9L21_RS04270	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H9L21_RS04275	COG0657	acetylesterase activity
H9L21_RS04280	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H9L21_RS04285	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H9L21_RS04300	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H9L21_RS04330	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H9L21_RS04335	COG0745	RESPONSE REGULATOR receiver
H9L21_RS04340	COG5000	phosphorelay sensor kinase activity
H9L21_RS04340	COG5002	protein histidine kinase activity
H9L21_RS04345	COG5401	PFAM Sporulation and spore germination
H9L21_RS04355	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H9L21_RS04360	COG2197	response regulator
H9L21_RS04365	COG3214	Protein conserved in bacteria
H9L21_RS04370	COG0653	protein targeting
H9L21_RS04385	COG0789	Transcriptional regulator
H9L21_RS04430	COG1842	Phage shock protein A
H9L21_RS04460	COG1530	ribonuclease E activity
H9L21_RS04465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H9L21_RS04470	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H9L21_RS04475	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H9L21_RS04480	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H9L21_RS04490	COG1289	transmembrane transporter activity
H9L21_RS04495	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H9L21_RS04505	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H9L21_RS04510	COG0799	negative regulation of ribosome biogenesis
H9L21_RS04515	COG0406	alpha-ribazole phosphatase activity
H9L21_RS04535	COG0577	efflux transmembrane transporter activity
H9L21_RS04540	COG1136	(ABC) transporter
H9L21_RS04540	COG0577	efflux transmembrane transporter activity
H9L21_RS04555	COG0477	Major facilitator Superfamily
H9L21_RS04560	COG3590	peptidase
H9L21_RS04575	COG0564	pseudouridine synthase activity
H9L21_RS04590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H9L21_RS04640	COG0778	Nitroreductase
H9L21_RS04660	COG1073	alpha beta
H9L21_RS04695	COG1595	DNA-templated transcription, initiation
H9L21_RS04705	COG3619	membrane
H9L21_RS04715	COG0154	amidase activity
H9L21_RS04725	COG2351	hydroxyisourate hydrolase activity
H9L21_RS04735	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H9L21_RS04740	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H9L21_RS04745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9L21_RS04760	COG2080	2 iron, 2 sulfur cluster binding
H9L21_RS04760	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H9L21_RS04770	COG0590	tRNA wobble adenosine to inosine editing
H9L21_RS04775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H9L21_RS04790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9L21_RS04805	COG0069	glutamate synthase activity
H9L21_RS04855	COG0477	Major facilitator Superfamily
H9L21_RS04870	COG1216	Glycosyl transferase, family 2
H9L21_RS04880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9L21_RS04885	COG0569	domain protein
H9L21_RS04890	COG0495	leucyl-tRNA aminoacylation
H9L21_RS04895	COG1307	EDD domain protein, DegV family
H9L21_RS04900	COG1555	photosystem II stabilization
H9L21_RS04900	COG1596	polysaccharide export
H9L21_RS04915	COG0268	Binds directly to 16S ribosomal RNA
H9L21_RS04925	COG0481	GTPase activity
H9L21_RS04935	COG0584	glycerophosphoryl diester phosphodiesterase
H9L21_RS04940	COG1022	Amp-dependent synthetase and ligase
H9L21_RS04955	COG2235	arginine
H9L21_RS04970	COG1420	regulation of RNA biosynthetic process
H9L21_RS04975	COG0484	heat shock protein binding
H9L21_RS04980	COG0537	adenosine 5'-monophosphoramidase activity
H9L21_RS04990	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H9L21_RS05005	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H9L21_RS05010	COG0583	DNA-binding transcription factor activity
H9L21_RS05030	COG0714	Associated with various cellular activities
H9L21_RS05045	COG0435	Glutathione S-transferase
H9L21_RS05050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H9L21_RS05070	COG1012	belongs to the aldehyde dehydrogenase family
H9L21_RS05075	COG1381	Involved in DNA repair and RecF pathway recombination
H9L21_RS05080	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H9L21_RS05090	COG0179	Fumarylacetoacetate (FAA) hydrolase
H9L21_RS05095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9L21_RS05120	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H9L21_RS05145	COG2814	Major facilitator Superfamily
H9L21_RS05165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9L21_RS05170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9L21_RS05175	COG0431	NADPH-dependent FMN reductase
H9L21_RS05185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9L21_RS05210	COG1414	Transcriptional regulator
H9L21_RS05215	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H9L21_RS05220	COG0066	3-isopropylmalate dehydratase activity
H9L21_RS05230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H9L21_RS05235	COG0626	cystathionine gamma-synthase activity
H9L21_RS05240	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9L21_RS05260	COG0154	amidase activity
H9L21_RS05265	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H9L21_RS05270	COG1461	Dihydroxyacetone kinase
H9L21_RS05280	COG0742	ribosomal rna small subunit methyltransferase
H9L21_RS05285	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H9L21_RS05290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9L21_RS05300	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H9L21_RS05305	COG0571	ribonuclease III activity
H9L21_RS05310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H9L21_RS05320	COG0358	DNA primase activity
H9L21_RS05350	COG0747	negative chemotaxis
H9L21_RS05375	COG0657	acetylesterase activity
H9L21_RS05400	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H9L21_RS05435	COG0739	heme binding
H9L21_RS05435	COG0741	lytic transglycosylase activity
H9L21_RS05435	COG1196	nuclear chromosome segregation
H9L21_RS05455	COG3022	response to hydroperoxide
H9L21_RS05460	COG2119	membrane
H9L21_RS05510	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H9L21_RS05520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H9L21_RS05520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9L21_RS05525	COG0174	glutamine synthetase
H9L21_RS05530	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H9L21_RS05565	COG2357	RelA SpoT domain protein
H9L21_RS05570	COG1960	acyl-CoA dehydrogenase activity
H9L21_RS05580	COG0318	PFAM AMP-dependent synthetase and ligase
H9L21_RS05595	COG0745	RESPONSE REGULATOR receiver
H9L21_RS05600	COG2205	protein histidine kinase activity
H9L21_RS05635	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H9L21_RS05650	COG0733	neurotransmitter:sodium symporter activity
H9L21_RS05675	COG0174	glutamine synthetase
H9L21_RS05705	COG2814	Major facilitator Superfamily
H9L21_RS05710	COG0321	lipoyl(octanoyl) transferase activity
H9L21_RS05725	COG1090	epimerase
H9L21_RS05730	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9L21_RS05735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9L21_RS05750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9L21_RS05755	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H9L21_RS05775	COG0501	Belongs to the peptidase M48B family
H9L21_RS05805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9L21_RS05820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9L21_RS05825	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H9L21_RS05830	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H9L21_RS05860	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H9L21_RS05865	COG0723	plastoquinol--plastocyanin reductase activity
H9L21_RS05870	COG2010	Cytochrome c
H9L21_RS05875	COG1845	cytochrome c oxidase, subunit III
H9L21_RS05880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H9L21_RS05900	COG0791	NLP P60 protein
H9L21_RS05905	COG1022	Amp-dependent synthetase and ligase
H9L21_RS05915	COG1940	carbohydrate kinase activity
H9L21_RS05935	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H9L21_RS05940	COG2815	serine threonine protein kinase
H9L21_RS05940	COG0515	serine threonine protein kinase
H9L21_RS05945	COG0142	geranyltranstransferase activity
H9L21_RS05960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9L21_RS05970	COG2001	Belongs to the MraZ family
H9L21_RS05975	COG0275	rRNA processing
H9L21_RS05985	COG0768	penicillin binding
H9L21_RS05990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H9L21_RS05995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H9L21_RS06000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9L21_RS06005	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H9L21_RS06015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H9L21_RS06020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9L21_RS06025	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H9L21_RS06040	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H9L21_RS06045	COG1799	cell septum assembly
H9L21_RS06055	COG3599	regulation of cell shape
H9L21_RS06060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H9L21_RS06065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H9L21_RS06110	COG0587	DNA-directed DNA polymerase activity
H9L21_RS06120	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H9L21_RS06125	COG3135	benzoate transporter
H9L21_RS06130	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H9L21_RS06135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H9L21_RS06140	COG0131	Imidazoleglycerol-phosphate dehydratase
H9L21_RS06145	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H9L21_RS06170	COG0107	imidazoleglycerol-phosphate synthase activity
H9L21_RS06180	COG1132	(ABC) transporter
H9L21_RS06185	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H9L21_RS06215	COG0134	indole-3-glycerol-phosphate synthase activity
H9L21_RS06220	COG0133	tryptophan synthase activity
H9L21_RS06225	COG0159	tryptophan synthase activity
H9L21_RS06230	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H9L21_RS06235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H9L21_RS06240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H9L21_RS06245	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H9L21_RS06265	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H9L21_RS06290	COG0783	Belongs to the Dps family
H9L21_RS06300	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H9L21_RS06305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9L21_RS06335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H9L21_RS06340	COG1074	ATP-dependent DNA helicase activity
H9L21_RS06355	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9L21_RS06380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H9L21_RS06400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L21_RS06405	COG2133	pyrroloquinoline quinone binding
H9L21_RS06410	COG1278	Cold shock
H9L21_RS06420	COG0644	oxidoreductase
H9L21_RS06430	COG0343	queuine tRNA-ribosyltransferase activity
H9L21_RS06460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9L21_RS06470	COG0667	Aldo Keto reductase
H9L21_RS06490	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H9L21_RS06495	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H9L21_RS06500	COG3253	May function as heme-dependent peroxidase
H9L21_RS06515	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9L21_RS06530	COG2326	polyphosphate kinase activity
H9L21_RS06550	COG1960	acyl-CoA dehydrogenase activity
H9L21_RS06585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H9L21_RS06600	COG0488	(ABC) transporter
H9L21_RS06620	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H9L21_RS06625	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H9L21_RS06630	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H9L21_RS06640	COG0135	phosphoribosylanthranilate isomerase activity
H9L21_RS06645	COG0798	PFAM Bile acid sodium symporter
H9L21_RS06655	COG0596	Alpha beta hydrolase
H9L21_RS06680	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H9L21_RS06690	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H9L21_RS06695	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
H9L21_RS06705	COG0681	Belongs to the peptidase S26 family
H9L21_RS06725	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
H9L21_RS06730	COG0217	transcriptional regulatory protein
H9L21_RS06740	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H9L21_RS06745	COG0632	four-way junction helicase activity
H9L21_RS06750	COG2255	four-way junction helicase activity
H9L21_RS06760	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9L21_RS06765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9L21_RS06770	COG1196	nuclear chromosome segregation
H9L21_RS06780	COG0124	histidyl-tRNA synthetase
H9L21_RS06785	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H9L21_RS06790	COG2318	DinB family
H9L21_RS06815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H9L21_RS06820	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H9L21_RS06830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H9L21_RS06840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H9L21_RS06845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H9L21_RS06850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H9L21_RS06855	COG0006	proline dipeptidase activity
H9L21_RS06860	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9L21_RS06865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9L21_RS06875	COG2837	iron assimilation
H9L21_RS06910	COG0604	alcohol dehydrogenase
H9L21_RS06915	COG0456	acetyltransferase
H9L21_RS06940	COG1403	HNH endonuclease
H9L21_RS06980	COG4585	Histidine kinase
H9L21_RS06985	COG2197	response regulator
H9L21_RS06990	COG1131	(ABC) transporter
H9L21_RS07000	COG0121	glutamine amidotransferase
H9L21_RS07005	COG1720	tRNA m6t6A37 methyltransferase activity
H9L21_RS07030	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H9L21_RS07035	COG0540	Belongs to the ATCase OTCase family
H9L21_RS07040	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H9L21_RS07045	COG0505	Belongs to the CarA family
H9L21_RS07050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H9L21_RS07055	COG0284	orotidine-5'-phosphate decarboxylase activity
H9L21_RS07090	COG0194	GDP metabolic process
H9L21_RS07095	COG1758	RNA polymerase activity
H9L21_RS07105	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H9L21_RS07125	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H9L21_RS07140	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9L21_RS07140	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9L21_RS07145	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H9L21_RS07150	COG0140	phosphoribosyl-ATP diphosphatase activity
H9L21_RS07155	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H9L21_RS07190	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H9L21_RS07195	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H9L21_RS07200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9L21_RS07205	COG5002	protein histidine kinase activity
H9L21_RS07210	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H9L21_RS07215	COG0072	phenylalanine-tRNA ligase activity
H9L21_RS07215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9L21_RS07225	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H9L21_RS07235	COG1403	HNH endonuclease
H9L21_RS07265	COG3304	Inner membrane component domain
H9L21_RS07270	COG4604	ABC transporter, ATP-binding protein
H9L21_RS07275	COG4605	iron ion homeostasis
H9L21_RS07280	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9L21_RS07285	COG4607	ABC-type enterochelin transport system periplasmic component
H9L21_RS07355	COG1643	Atp-dependent helicase
H9L21_RS07420	COG2153	protein acetylation
H9L21_RS07435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H9L21_RS07440	COG1121	(ABC) transporter
H9L21_RS07445	COG3443	Belongs to the bacterial solute-binding protein 9 family
H9L21_RS07445	COG0803	Belongs to the bacterial solute-binding protein 9 family
H9L21_RS07450	COG0423	glycine-tRNA ligase activity
H9L21_RS07485	COG0824	Thioesterase
H9L21_RS07495	COG1271	oxidase subunit
H9L21_RS07500	COG1294	oxidase, subunit
H9L21_RS07505	COG4988	ABC transporter
H9L21_RS07510	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H9L21_RS07530	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H9L21_RS07540	COG3265	gluconokinase activity
H9L21_RS07560	COG1160	GTP binding
H9L21_RS07565	COG2066	Belongs to the glutaminase family
H9L21_RS07570	COG1403	HNH endonuclease
H9L21_RS07575	COG0039	L-malate dehydrogenase activity
H9L21_RS07655	COG1053	succinate dehydrogenase
H9L21_RS07665	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H9L21_RS07680	COG0531	amino acid
H9L21_RS07685	COG0076	glutamate decarboxylase activity
H9L21_RS07695	COG3467	pyridoxamine 5'-phosphate
H9L21_RS07730	COG2197	response regulator
H9L21_RS07740	COG0515	serine threonine protein kinase
H9L21_RS07740	COG2815	serine threonine protein kinase
H9L21_RS07745	COG0659	secondary active sulfate transmembrane transporter activity
H9L21_RS07770	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H9L21_RS07775	COG0697	spore germination
H9L21_RS07780	COG0739	heme binding
H9L21_RS07820	COG0509	glycine decarboxylation via glycine cleavage system
H9L21_RS07825	COG1716	ATPase activity
H9L21_RS07845	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9L21_RS07845	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9L21_RS07865	COG1648	precorrin-2 dehydrogenase activity
H9L21_RS07865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H9L21_RS07870	COG0175	sulfate reduction
H9L21_RS07880	COG0009	L-threonylcarbamoyladenylate synthase
H9L21_RS07910	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H9L21_RS07940	COG0640	Transcriptional regulator
H9L21_RS07980	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H9L21_RS07995	COG2154	pterin-4-alpha-carbinolamine dehydratase
H9L21_RS08000	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H9L21_RS08005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9L21_RS08010	COG3655	Transcriptional regulator
H9L21_RS08020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9L21_RS08045	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H9L21_RS08050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H9L21_RS08070	COG0463	Glycosyl transferase, family 2
H9L21_RS08090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9L21_RS08095	COG4581	dead DEAH box helicase
H9L21_RS08100	COG0805	protein transport
H9L21_RS08125	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H9L21_RS08130	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H9L21_RS08135	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H9L21_RS08145	COG4122	O-methyltransferase activity
H9L21_RS08155	COG1222	aaa ATPase
H9L21_RS08175	COG1994	Peptidase M50
H9L21_RS08175	COG0517	IMP dehydrogenase activity
H9L21_RS08180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9L21_RS08185	COG0582	viral genome integration into host DNA
H9L21_RS08220	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H9L21_RS08225	COG0477	Major facilitator Superfamily
H9L21_RS08230	COG0646	methionine synthase
H9L21_RS08230	COG1410	methionine synthase
H9L21_RS08240	COG0215	cysteine-tRNA ligase activity
H9L21_RS08245	COG0598	Magnesium transport protein CorA
H9L21_RS08250	COG1968	undecaprenyl-diphosphatase activity
H9L21_RS08255	COG0667	Aldo Keto reductase
H9L21_RS08265	COG1295	ribonuclease BN
H9L21_RS08285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9L21_RS08325	COG1388	LysM domain
H9L21_RS08325	COG0791	NLP P60 protein
H9L21_RS08345	COG0559	Belongs to the binding-protein-dependent transport system permease family
H9L21_RS08355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H9L21_RS08365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H9L21_RS08395	COG2733	membrane
H9L21_RS08410	COG1643	Atp-dependent helicase
H9L21_RS08420	COG0545	Peptidyl-prolyl cis-trans isomerase
H9L21_RS08430	COG1960	acyl-CoA dehydrogenase activity
H9L21_RS08435	COG1960	acyl-CoA dehydrogenase activity
H9L21_RS08440	COG0242	peptide deformylase activity
H9L21_RS08450	COG1881	PFAM PEBP family protein
H9L21_RS08470	COG1119	ATPase activity
H9L21_RS08475	COG0560	Phosphoserine phosphatase
H9L21_RS08475	COG3830	Belongs to the UPF0237 family
H9L21_RS08480	COG3360	Dodecin
H9L21_RS08495	COG0488	(ABC) transporter
H9L21_RS08500	COG2151	metal-sulfur cluster biosynthetic enzyme
H9L21_RS08505	COG0822	iron-sulfur transferase activity
H9L21_RS08510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H9L21_RS08515	COG0396	ATPase activity
H9L21_RS08565	COG1793	dna ligase
H9L21_RS08580	COG1612	heme a metabolic process
H9L21_RS08595	COG0109	protoheme IX farnesyltransferase activity
H9L21_RS08605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H9L21_RS08610	COG0166	Belongs to the GPI family
H9L21_RS08625	COG0363	glucosamine-6-phosphate deaminase activity
H9L21_RS08635	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H9L21_RS08640	COG0149	triose-phosphate isomerase activity
H9L21_RS08645	COG0126	phosphoglycerate kinase activity
H9L21_RS08650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H9L21_RS08655	COG1481	regulation of sporulation
H9L21_RS08665	COG1660	Displays ATPase and GTPase activities
H9L21_RS08670	COG0322	excinuclease ABC activity
H9L21_RS08675	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H9L21_RS08685	COG2124	cytochrome p450
H9L21_RS08690	COG0531	amino acid
H9L21_RS08700	COG0556	nucleotide-excision repair
H9L21_RS08720	COG0183	Belongs to the thiolase family
H9L21_RS08735	COG1946	Acyl-CoA thioesterase
H9L21_RS08745	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H9L21_RS08755	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H9L21_RS08765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9L21_RS08770	COG0531	amino acid
H9L21_RS08775	COG0569	domain protein
H9L21_RS08800	COG0756	dUTP diphosphatase activity
H9L21_RS08825	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H9L21_RS08840	COG1435	thymidine kinase activity
H9L21_RS08860	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H9L21_RS08870	COG0477	Major facilitator Superfamily
H9L21_RS08900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H9L21_RS08970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9L21_RS08985	COG0237	dephospho-CoA kinase activity
H9L21_RS09010	COG0539	negative regulation of cytoplasmic translation
H9L21_RS09015	COG1362	aminopeptidase activity
H9L21_RS09020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9L21_RS09025	COG0500	methyltransferase
H9L21_RS09045	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H9L21_RS09050	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H9L21_RS09065	COG4981	capsule polysaccharide biosynthetic process
H9L21_RS09080	COG0438	transferase activity, transferring glycosyl groups
H9L21_RS09085	COG1215	transferase activity, transferring glycosyl groups
H9L21_RS09110	COG2755	lipolytic protein G-D-S-L family
H9L21_RS09110	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H9L21_RS09115	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H9L21_RS09145	COG0559	Belongs to the binding-protein-dependent transport system permease family
H9L21_RS09180	COG0469	pyruvate kinase activity
H9L21_RS09190	COG0067	glutamate synthase
H9L21_RS09190	COG0069	glutamate synthase activity
H9L21_RS09190	COG0070	glutamate synthase
H9L21_RS09195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9L21_RS09210	COG1126	abc transporter atp-binding protein
H9L21_RS09215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9L21_RS09220	COG0765	amino acid transport
H9L21_RS09225	COG0765	amino acid transport
H9L21_RS09230	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H9L21_RS09240	COG2137	regulation of response to DNA damage stimulus
H9L21_RS09245	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H9L21_RS09250	COG0693	protein deglycase activity
H9L21_RS09260	COG1396	sequence-specific DNA binding
H9L21_RS09265	COG1546	Belongs to the CinA family
H9L21_RS09265	COG1058	Belongs to the CinA family
H9L21_RS09280	COG1674	ftsk spoiiie
H9L21_RS09290	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H9L21_RS09295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9L21_RS09315	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H9L21_RS09355	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H9L21_RS09360	COG3842	ATPase activity
H9L21_RS09380	COG1175	transmembrane transport
H9L21_RS09390	COG1185	polyribonucleotide nucleotidyltransferase activity
H9L21_RS09425	COG3185	4-Hydroxyphenylpyruvate dioxygenase
H9L21_RS09440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9L21_RS09445	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H9L21_RS09450	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H9L21_RS09455	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H9L21_RS09470	COG0779	Required for maturation of 30S ribosomal subunits
H9L21_RS09500	COG0442	prolyl-tRNA aminoacylation
H9L21_RS09515	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H9L21_RS09520	COG0750	zinc metalloprotease
H9L21_RS09550	COG4585	Histidine kinase
H9L21_RS09555	COG2197	response regulator
H9L21_RS09560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H9L21_RS09575	COG2308	Evidence 4 Homologs of previously reported genes of
H9L21_RS09575	COG2307	Protein conserved in bacteria
H9L21_RS09580	COG0575	Belongs to the CDS family
H9L21_RS09585	COG0233	cytoplasmic translational termination
H9L21_RS09590	COG0528	UMP kinase activity
H9L21_RS09595	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H9L21_RS09600	COG0052	Belongs to the universal ribosomal protein uS2 family
H9L21_RS09605	COG0739	heme binding
H9L21_RS09605	COG1196	nuclear chromosome segregation
H9L21_RS09605	COG0741	lytic transglycosylase activity
H9L21_RS09640	COG0315	cyclic pyranopterin monophosphate synthase activity
H9L21_RS09665	COG0792	nuclease activity
H9L21_RS09680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H9L21_RS09690	COG0681	Belongs to the peptidase S26 family
H9L21_RS09695	COG0335	large ribosomal subunit rRNA binding
H9L21_RS09705	COG0336	Belongs to the RNA methyltransferase TrmD family
H9L21_RS09710	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H9L21_RS09715	COG1837	Belongs to the UPF0109 family
H9L21_RS09725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H9L21_RS09740	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H9L21_RS09770	COG0504	CTP synthase activity
H9L21_RS09785	COG0497	DNA recombination
H9L21_RS09790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H9L21_RS09805	COG0647	UMP catabolic process
H9L21_RS09835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H9L21_RS09840	COG0589	response to stress
H9L21_RS09850	COG2094	Belongs to the DNA glycosylase MPG family
H9L21_RS09870	COG0165	Argininosuccinate lyase
H9L21_RS09875	COG1438	arginine binding
H9L21_RS09880	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H9L21_RS09885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H9L21_RS09890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H9L21_RS09895	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H9L21_RS09900	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H9L21_RS09905	COG0137	argininosuccinate synthase activity
H9L21_RS09915	COG1704	LemA family
H9L21_RS09920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H9L21_RS09925	COG0473	3-isopropylmalate dehydrogenase activity
H9L21_RS09945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9L21_RS09950	COG0531	amino acid
H9L21_RS09960	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H9L21_RS09965	COG0440	acetolactate synthase activity
H9L21_RS09985	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H9L21_RS09985	COG2755	lipolytic protein G-D-S-L family
H9L21_RS09990	COG0129	dihydroxy-acid dehydratase activity
H9L21_RS10005	COG1752	Esterase of the alpha-beta hydrolase superfamily
H9L21_RS10035	COG1403	HNH endonuclease
H9L21_RS10040	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H9L21_RS10045	COG0154	amidase activity
H9L21_RS10050	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H9L21_RS10060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H9L21_RS10085	COG0482	sulfurtransferase activity
H9L21_RS10160	COG1674	ftsk spoiiie
H9L21_RS10230	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H9L21_RS10235	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H9L21_RS10250	COG0587	DNA-directed DNA polymerase activity
H9L21_RS10275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9L21_RS10280	COG0601	transmembrane transport
H9L21_RS10290	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H9L21_RS10295	COG2086	electron transfer activity
H9L21_RS10335	COG0183	Belongs to the thiolase family
H9L21_RS10370	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9L21_RS10380	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
H9L21_RS10390	COG1528	Iron-storage protein
H9L21_RS10400	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9L21_RS10400	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9L21_RS10415	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H9L21_RS10420	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H9L21_RS10425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H9L21_RS10430	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H9L21_RS10435	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9L21_RS10440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H9L21_RS10445	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9L21_RS10450	COG0356	it plays a direct role in the translocation of protons across the membrane
H9L21_RS10460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9L21_RS10465	COG0009	L-threonylcarbamoyladenylate synthase
H9L21_RS10475	COG2890	protein-(glutamine-N5) methyltransferase activity
H9L21_RS10480	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H9L21_RS10485	COG0254	rRNA binding
H9L21_RS10495	COG0386	Belongs to the glutathione peroxidase family
H9L21_RS10505	COG0083	homoserine kinase activity
H9L21_RS10510	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H9L21_RS10515	COG0460	homoserine dehydrogenase
H9L21_RS10520	COG0569	domain protein
H9L21_RS10520	COG2985	domain, Protein
H9L21_RS10535	COG0018	arginyl-trna synthetase
H9L21_RS10580	COG0640	Transcriptional regulator
H9L21_RS10585	COG2226	methyltransferase
H9L21_RS10595	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H9L21_RS10600	COG1764	response to oxidative stress
H9L21_RS10605	COG0567	Dehydrogenase, E1 component
H9L21_RS10605	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9L21_RS10620	COG0604	alcohol dehydrogenase
H9L21_RS10660	COG1595	DNA-templated transcription, initiation
H9L21_RS10665	COG2135	peptidase activity
H9L21_RS10690	COG1162	GTPase activity
H9L21_RS10695	COG0483	inositol monophosphate 1-phosphatase activity
H9L21_RS10710	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H9L21_RS10715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9L21_RS10720	COG2340	Cysteine-rich secretory protein family
H9L21_RS10745	COG1960	acyl-CoA dehydrogenase activity
H9L21_RS10775	COG0829	nickel cation binding
H9L21_RS10780	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H9L21_RS10800	COG0831	urea catabolic process
H9L21_RS10835	COG0310	cobalt ion transport
H9L21_RS10840	COG1132	(ABC) transporter
H9L21_RS10845	COG2860	membrane
H9L21_RS10890	COG1703	isobutyryl-CoA mutase activity
H9L21_RS10890	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9L21_RS10890	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9L21_RS10900	COG0419	ATPase involved in DNA repair
H9L21_RS10930	COG0318	PFAM AMP-dependent synthetase and ligase
H9L21_RS10935	COG1028	Short-chain dehydrogenase reductase Sdr
H9L21_RS10940	COG1960	acyl-CoA dehydrogenase activity
H9L21_RS10960	COG2890	protein-(glutamine-N5) methyltransferase activity
H9L21_RS10965	COG1028	Short-chain dehydrogenase reductase Sdr
H9L21_RS10985	COG0723	plastoquinol--plastocyanin reductase activity
H9L21_RS10985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9L21_RS11005	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H9L21_RS11060	COG1937	Protein conserved in bacteria
H9L21_RS11075	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H9L21_RS11090	COG1136	(ABC) transporter
H9L21_RS11095	COG2197	response regulator
H9L21_RS11130	COG1063	alcohol dehydrogenase
H9L21_RS11140	COG0789	Transcriptional regulator
H9L21_RS11150	COG1403	HNH endonuclease
H9L21_RS11175	COG1595	DNA-templated transcription, initiation
H9L21_RS11240	COG1201	RNA secondary structure unwinding
H9L21_RS11250	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H9L21_RS11310	COG1525	nuclease
H9L21_RS11315	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H9L21_RS11340	COG0028	Belongs to the TPP enzyme family
H9L21_RS11380	COG2066	Belongs to the glutaminase family
H9L21_RS11385	COG2267	carboxylic ester hydrolase activity
H9L21_RS11390	COG0515	serine threonine protein kinase
H9L21_RS11400	COG1131	(ABC) transporter
H9L21_RS11405	COG1672	PFAM Archaeal ATPase
H9L21_RS11405	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H9L21_RS11410	COG0686	Belongs to the AlaDH PNT family
H9L21_RS11425	COG1012	belongs to the aldehyde dehydrogenase family
H9L21_RS11435	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9L21_RS11435	COG1902	pentaerythritol trinitrate reductase activity
H9L21_RS11445	COG0765	amino acid transport
H9L21_RS11450	COG0765	amino acid transport
H9L21_RS11455	COG1126	abc transporter atp-binding protein
H9L21_RS11470	COG0028	Belongs to the TPP enzyme family
H9L21_RS11475	COG0442	prolyl-tRNA aminoacylation
H9L21_RS11480	COG1615	UPF0182 protein
H9L21_RS11490	COG3480	Lon protease (S16) C-terminal proteolytic domain
H9L21_RS11520	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H9L21_RS11545	COG2816	NAD+ diphosphatase activity
H9L21_RS11550	COG0210	DNA helicase
H9L21_RS11570	COG1309	transcriptional regulator
H9L21_RS11585	COG0513	Belongs to the DEAD box helicase family
H9L21_RS11630	COG0613	PHP domain protein
H9L21_RS11635	COG0588	phosphoglycerate mutase activity
H9L21_RS11640	COG2030	dehydratase
H9L21_RS11660	COG1960	acyl-CoA dehydrogenase activity
H9L21_RS11700	COG1028	Short-chain dehydrogenase reductase Sdr
H9L21_RS11705	COG1028	Short-chain dehydrogenase reductase Sdr
H9L21_RS11710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H9L21_RS11715	COG0183	Belongs to the thiolase family
H9L21_RS11730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9L21_RS11740	COG2301	Belongs to the HpcH HpaI aldolase family
H9L21_RS11745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H9L21_RS11760	COG1028	Short-chain dehydrogenase reductase Sdr
H9L21_RS11770	COG3842	ATPase activity
H9L21_RS11795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H9L21_RS11810	COG1960	acyl-CoA dehydrogenase activity
H9L21_RS11820	COG2239	Acts as a magnesium transporter
H9L21_RS11835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9L21_RS11845	COG4122	O-methyltransferase activity
H9L21_RS11870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9L21_RS11880	COG1136	(ABC) transporter
H9L21_RS11880	COG0577	efflux transmembrane transporter activity
H9L21_RS11895	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H9L21_RS11900	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H9L21_RS11910	COG1234	tRNA 3'-trailer cleavage
H9L21_RS11915	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H9L21_RS11920	COG2723	6-phospho-beta-galactosidase activity
H9L21_RS11925	COG2211	Major facilitator Superfamily
H9L21_RS11930	COG1764	response to oxidative stress
H9L21_RS11935	COG1846	Transcriptional regulator
H9L21_RS11940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H9L21_RS11970	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H9L21_RS11980	COG1335	isochorismatase
H9L21_RS11985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9L21_RS12000	COG0657	acetylesterase activity
H9L21_RS12015	COG1678	Uncharacterized ACR, COG1678
H9L21_RS12030	COG1201	RNA secondary structure unwinding
H9L21_RS12035	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H9L21_RS12045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9L21_RS12050	COG2072	flavoprotein involved in K transport
H9L21_RS12115	COG1278	Cold shock
H9L21_RS12130	COG1902	pentaerythritol trinitrate reductase activity
H9L21_RS12150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H9L21_RS12165	COG2884	Cell division ATP-binding protein ftsE
H9L21_RS12170	COG2837	iron assimilation
H9L21_RS12180	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H9L21_RS12185	COG2072	flavoprotein involved in K transport
H9L21_RS12190	COG1920	GTP binding
H9L21_RS12200	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H9L21_RS12205	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
H9L21_RS12205	COG0778	Nitroreductase
H9L21_RS12295	COG0668	transmembrane transport
H9L21_RS12310	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H9L21_RS12315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9L21_RS12340	COG0736	holo-[acyl-carrier-protein] synthase activity
H9L21_RS12345	COG2030	dehydratase
H9L21_RS12350	COG1028	Short-chain dehydrogenase reductase Sdr
H9L21_RS12355	COG0183	Belongs to the thiolase family
H9L21_RS12360	COG1960	acyl-CoA dehydrogenase activity
H9L21_RS12370	COG2353	YceI-like domain
H9L21_RS12395	COG2835	tetraacyldisaccharide 4'-kinase activity
H9L21_RS12435	COG1134	teichoic acid transport
H9L21_RS12435	COG1388	LysM domain
H9L21_RS12440	COG1316	TRANSCRIPTIONal
H9L21_RS12450	COG1316	TRANSCRIPTIONal
H9L21_RS12485	COG1960	acyl-CoA dehydrogenase activity
H9L21_RS12510	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H9L21_RS12520	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H9L21_RS12520	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H9L21_RS12530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9L21_RS12545	COG0424	maF-like protein
H9L21_RS12565	COG1960	acyl-CoA dehydrogenase activity
H9L21_RS12575	COG4770	biotin carboxylase activity
H9L21_RS12585	COG2385	sporulation resulting in formation of a cellular spore
H9L21_RS12595	COG5398	heme oxygenase
H9L21_RS12600	COG1120	ATPase activity
H9L21_RS12605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9L21_RS12610	COG4558	Periplasmic binding protein
H9L21_RS12635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9L21_RS12650	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H9L21_RS12655	COG1012	belongs to the aldehyde dehydrogenase family
H9L21_RS12660	COG1012	belongs to the aldehyde dehydrogenase family
H9L21_RS12670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H9L21_RS12685	COG2124	cytochrome p450
H9L21_RS12695	COG1079	Belongs to the binding-protein-dependent transport system permease family
H9L21_RS12700	COG4603	Belongs to the binding-protein-dependent transport system permease family
H9L21_RS12705	COG3845	ABC transporter
H9L21_RS12710	COG1744	ABC transporter substrate-binding protein PnrA-like
H9L21_RS12720	COG1473	amidohydrolase
H9L21_RS12720	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H9L21_RS12745	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H9L21_RS12750	COG1053	succinate dehydrogenase
H9L21_RS12760	COG0583	DNA-binding transcription factor activity
H9L21_RS12770	COG0180	Tryptophanyl-tRNA synthetase
H9L21_RS12775	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H9L21_RS12780	COG3559	Exporter of polyketide antibiotics
H9L21_RS12785	COG1131	(ABC) transporter
H9L21_RS12790	COG0077	Prephenate dehydratase
H9L21_RS12795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9L21_RS12805	COG2838	Isocitrate dehydrogenase
H9L21_RS12810	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H9L21_RS12820	COG4208	sulfate ABC transporter
H9L21_RS12830	COG2814	Major facilitator Superfamily
H9L21_RS12840	COG0405	Gamma-glutamyltransferase
H9L21_RS12870	COG2197	response regulator
H9L21_RS12890	COG0045	succinate-CoA ligase (ADP-forming) activity
H9L21_RS12915	COG0138	bifunctional purine biosynthesis protein purh
H9L21_RS12925	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H9L21_RS12945	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H9L21_RS12945	COG0519	Catalyzes the synthesis of GMP from XMP
H9L21_RS12970	COG1970	mechanosensitive ion channel activity
H9L21_RS12995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9L21_RS13025	COG0259	pyridoxamine-phosphate oxidase activity
H9L21_RS13040	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H9L21_RS13045	COG2755	lipolytic protein G-D-S-L family
H9L21_RS13045	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H9L21_RS13050	COG1305	Transglutaminase-like
H9L21_RS13075	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H9L21_RS13105	COG1278	Cold shock
H9L21_RS13120	COG0318	PFAM AMP-dependent synthetase and ligase
H9L21_RS13125	COG0529	Catalyzes the synthesis of activated sulfate
H9L21_RS13130	COG0730	response to heat
H9L21_RS13135	COG0175	sulfate reduction
H9L21_RS13165	COG0577	efflux transmembrane transporter activity
H9L21_RS13165	COG1136	(ABC) transporter
H9L21_RS13175	COG0459	protein refolding
H9L21_RS13180	COG1278	Cold shock
H9L21_RS13185	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H9L21_RS13210	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H9L21_RS13220	COG0076	glutamate decarboxylase activity
H9L21_RS13235	COG2223	nitrite transmembrane transporter activity
H9L21_RS13240	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H9L21_RS13245	COG0628	permease
H9L21_RS13305	COG0215	cysteine-tRNA ligase activity
H9L21_RS13315	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H9L21_RS13330	COG1329	Transcriptional regulator
H9L21_RS13345	COG5002	protein histidine kinase activity
H9L21_RS13350	COG0745	RESPONSE REGULATOR receiver
H9L21_RS13355	COG0588	phosphoglycerate mutase activity
H9L21_RS13370	COG0438	transferase activity, transferring glycosyl groups
H9L21_RS13405	COG2211	Major facilitator Superfamily
H9L21_RS13410	COG0300	oxidoreductase activity
H9L21_RS13425	COG2409	Drug exporters of the RND superfamily
H9L21_RS13435	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H9L21_RS13450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9L21_RS13470	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H9L21_RS13475	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H9L21_RS13485	COG1216	Glycosyl transferase, family 2
H9L21_RS13495	COG0438	transferase activity, transferring glycosyl groups
H9L21_RS13505	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H9L21_RS13510	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H9L21_RS13520	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H9L21_RS13525	COG0302	gtp cyclohydrolase
H9L21_RS13540	COG0037	tRNA processing
H9L21_RS13555	COG2027	D-alanyl-D-alanine carboxypeptidase
H9L21_RS13560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H9L21_RS13580	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H9L21_RS13585	COG2818	Glycosylase
H9L21_RS13605	COG3845	ABC transporter
H9L21_RS13640	COG1846	Transcriptional regulator
H9L21_RS13650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9L21_RS13655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9L21_RS13660	COG1120	ATPase activity
H9L21_RS13680	COG1252	NADH dehydrogenase
H9L21_RS13690	COG0542	response to heat
H9L21_RS13725	COG1063	alcohol dehydrogenase
H9L21_RS13735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9L21_RS13750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9L21_RS13750	COG1017	nitric oxide dioxygenase activity
H9L21_RS13820	COG2040	homocysteine
H9L21_RS13825	COG0318	PFAM AMP-dependent synthetase and ligase
H9L21_RS13840	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H9L21_RS13880	COG0789	Transcriptional regulator
H9L21_RS13885	COG0484	heat shock protein binding
H9L21_RS13890	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H9L21_RS13895	COG0443	Heat shock 70 kDa protein
H9L21_RS13900	COG4585	Histidine kinase
H9L21_RS13905	COG2197	response regulator
H9L21_RS13910	COG0577	efflux transmembrane transporter activity
H9L21_RS13910	COG1136	(ABC) transporter
H9L21_RS13930	COG2072	flavoprotein involved in K transport
H9L21_RS13945	COG2409	Drug exporters of the RND superfamily
H9L21_RS13970	COG2252	PERMEase
H9L21_RS13990	COG0154	amidase activity
H9L21_RS13995	COG0024	Methionine aminopeptidase
H9L21_RS14005	COG1028	Short-chain dehydrogenase reductase Sdr
H9L21_RS14020	COG3764	Sortase (surface protein transpeptidase)
H9L21_RS14065	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H9L21_RS14070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H9L21_RS14090	COG3845	ABC transporter
H9L21_RS14095	COG4721	ABC-type cobalt transport system, permease component
H9L21_RS14115	COG0247	lactate metabolic process
H9L21_RS14115	COG2181	nitrate reductase activity
H9L21_RS14125	COG1131	(ABC) transporter
H9L21_RS14130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9L21_RS14135	COG2313	pseudouridylate synthase activity
H9L21_RS14140	COG0561	phosphatase activity
H9L21_RS14145	COG0717	Belongs to the dCTP deaminase family
H9L21_RS14175	COG2267	carboxylic ester hydrolase activity
H9L21_RS14185	COG2233	PERMEase
H9L21_RS14195	COG0583	DNA-binding transcription factor activity
H9L21_RS14200	COG1960	acyl-CoA dehydrogenase activity
H9L21_RS14235	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9L21_RS14240	COG0022	dehydrogenase e1 component
H9L21_RS14250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H9L21_RS14255	COG0697	spore germination
H9L21_RS14265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9L21_RS14270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9L21_RS14275	COG3001	Fructosamine kinase
H9L21_RS14290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9L21_RS14305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9L21_RS14315	COG0805	protein transport
H9L21_RS14375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9L21_RS14385	COG1960	acyl-CoA dehydrogenase activity
H9L21_RS14435	COG0657	acetylesterase activity
H9L21_RS14450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H9L21_RS14460	COG0513	Belongs to the DEAD box helicase family
H9L21_RS14470	COG2130	NADP-dependent
H9L21_RS14510	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9L21_RS14515	COG1129	ABC transporter
H9L21_RS14525	COG1028	Short-chain dehydrogenase reductase Sdr
H9L21_RS14530	COG0318	PFAM AMP-dependent synthetase and ligase
H9L21_RS14535	COG1879	ABC-type sugar transport system periplasmic component
H9L21_RS14555	COG3321	synthase
H9L21_RS14555	COG0604	alcohol dehydrogenase
H9L21_RS14555	COG1028	Short-chain dehydrogenase reductase Sdr
H9L21_RS14570	COG1024	Enoyl-CoA hydratase
H9L21_RS14580	COG0778	Nitroreductase
H9L21_RS14595	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H9L21_RS14595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9L21_RS14595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9L21_RS14605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9L21_RS14615	COG0702	epimerase
H9L21_RS14620	COG0531	amino acid
H9L21_RS14640	COG0489	protein tyrosine kinase activity
H9L21_RS14645	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9L21_RS14665	COG1024	Enoyl-CoA hydratase
H9L21_RS14665	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9L21_RS14670	COG0183	Belongs to the thiolase family
H9L21_RS14690	COG0438	transferase activity, transferring glycosyl groups
H9L21_RS14710	COG0438	transferase activity, transferring glycosyl groups
H9L21_RS14725	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H9L21_RS14745	COG1960	acyl-CoA dehydrogenase activity
H9L21_RS14755	COG2030	dehydratase
H9L21_RS14760	COG1028	Short-chain dehydrogenase reductase Sdr
H9L21_RS14780	COG0747	negative chemotaxis
H9L21_RS14785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9L21_RS14790	COG0601	transmembrane transport
H9L21_RS14800	COG0444	Belongs to the ABC transporter superfamily
H9L21_RS14805	COG2814	Major facilitator Superfamily
H9L21_RS14810	COG1960	acyl-CoA dehydrogenase activity
H9L21_RS14815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H9L21_RS14820	COG2267	carboxylic ester hydrolase activity
H9L21_RS14835	COG0765	amino acid transport
H9L21_RS14840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9L21_RS14860	COG1902	pentaerythritol trinitrate reductase activity
H9L21_RS14860	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9L21_RS14875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9L21_RS14885	COG1937	Protein conserved in bacteria
H9L21_RS14910	COG1132	(ABC) transporter
H9L21_RS14930	COG0586	Pfam SNARE associated Golgi protein
H9L21_RS14940	COG0436	Aminotransferase
H9L21_RS14950	COG0572	uridine kinase
H9L21_RS14965	COG4585	Histidine kinase
H9L21_RS14980	COG0483	inositol monophosphate 1-phosphatase activity
H9L21_RS14985	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H9L21_RS14990	COG0352	thiamine-phosphate diphosphorylase activity
H9L21_RS14995	COG0352	thiamine-phosphate diphosphorylase activity
H9L21_RS14995	COG0351	phosphomethylpyrimidine kinase
H9L21_RS14995	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H9L21_RS15030	COG2936	dipeptidyl-peptidase activity
H9L21_RS15085	COG0305	Participates in initiation and elongation during chromosome replication
H9L21_RS15090	COG0534	Mate efflux family protein
H9L21_RS15095	COG2375	cellular response to nickel ion
H9L21_RS15105	COG0359	binds to the 23S rRNA
H9L21_RS15110	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H9L21_RS15120	COG0360	Binds together with S18 to 16S ribosomal RNA
H9L21_RS15125	COG1136	(ABC) transporter
H9L21_RS15125	COG0577	efflux transmembrane transporter activity
H9L21_RS15130	COG1136	(ABC) transporter
H9L21_RS15130	COG0577	efflux transmembrane transporter activity
H9L21_RS15135	COG0667	Aldo Keto reductase
H9L21_RS15180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9L21_RS15185	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H9L21_RS15190	COG1260	myo-inositol-1-phosphate synthase
H9L21_RS15195	COG2318	DinB family
H9L21_RS15200	COG2354	Protein conserved in bacteria
H9L21_RS15215	COG0410	ABC transporter
H9L21_RS15225	COG1022	Amp-dependent synthetase and ligase
H9L21_RS15245	COG0488	(ABC) transporter
H9L21_RS15255	COG0617	tRNA 3'-terminal CCA addition
H9L21_RS15270	COG0515	serine threonine protein kinase
H9L21_RS15270	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9L21_RS15275	COG0492	ferredoxin-NADP+ reductase activity
H9L21_RS15280	COG3118	belongs to the thioredoxin family
H9L21_RS15290	COG1192	Involved in chromosome partitioning
H9L21_RS15295	COG0357	Ribosomal RNA small subunit methyltransferase G
H9L21_RS15305	COG0706	membrane insertase activity
H9L21_RS15310	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H9L21_RS15315	COG0594	ribonuclease P activity
H9L21_RS15320	COG0230	Belongs to the bacterial ribosomal protein bL34 family