locus-tag	class	description
GWG05_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GWG05_RS00010	COG0592	DNA-directed DNA polymerase activity
GWG05_RS00020	COG0187	DNA topoisomerase II activity
GWG05_RS00025	COG2207	Transcriptional regulator
GWG05_RS00030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GWG05_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
GWG05_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
GWG05_RS00045	COG3977	Valine--pyruvate aminotransferase
GWG05_RS00065	COG0745	RESPONSE REGULATOR receiver
GWG05_RS00070	COG2205	protein histidine kinase activity
GWG05_RS00090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWG05_RS00095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG05_RS00095	COG4191	Histidine kinase
GWG05_RS00100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWG05_RS00105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG05_RS00110	COG1309	transcriptional regulator
GWG05_RS00140	COG0561	phosphatase activity
GWG05_RS00145	COG2267	carboxylic ester hydrolase activity
GWG05_RS00150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWG05_RS00155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWG05_RS00160	COG1758	RNA polymerase activity
GWG05_RS00170	COG0859	PFAM glycosyl transferase family 9
GWG05_RS00175	COG3642	lipopolysaccharide core region biosynthetic process
GWG05_RS00215	COG0589	response to stress
GWG05_RS00220	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GWG05_RS00225	COG3706	GGDEF domain
GWG05_RS00230	COG1528	Iron-storage protein
GWG05_RS00235	COG2081	HI0933 family
GWG05_RS00240	COG2223	nitrite transmembrane transporter activity
GWG05_RS00260	COG3188	usher protein
GWG05_RS00285	COG5433	transposase activity
GWG05_RS00300	COG3275	phosphorelay sensor kinase activity
GWG05_RS00305	COG3279	Response regulator of the LytR AlgR family
GWG05_RS00310	COG2223	nitrite transmembrane transporter activity
GWG05_RS00315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GWG05_RS00320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GWG05_RS00370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GWG05_RS00375	COG2166	iron-sulfur cluster assembly
GWG05_RS00380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GWG05_RS00400	COG1063	alcohol dehydrogenase
GWG05_RS00415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWG05_RS00460	COG1609	Transcriptional regulator
GWG05_RS00475	COG1580	Controls the rotational direction of flagella during chemotaxis
GWG05_RS00480	COG3161	chorismate lyase activity
GWG05_RS00485	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GWG05_RS00490	COG2937	Belongs to the GPAT DAPAT family
GWG05_RS00495	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWG05_RS00515	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GWG05_RS00520	COG2205	protein histidine kinase activity
GWG05_RS00525	COG0745	RESPONSE REGULATOR receiver
GWG05_RS00535	COG1045	serine acetyltransferase
GWG05_RS00545	COG3074	FtsZ-dependent cytokinesis
GWG05_RS00550	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GWG05_RS00555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWG05_RS00555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWG05_RS00560	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GWG05_RS00595	COG1609	Transcriptional regulator
GWG05_RS00600	COG3250	beta-galactosidase activity
GWG05_RS00605	COG2731	YhcH YjgK YiaL family protein
GWG05_RS00610	COG0531	amino acid
GWG05_RS00615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWG05_RS00620	COG0531	amino acid
GWG05_RS00625	COG0385	Bile acid
GWG05_RS00630	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWG05_RS00655	COG0583	DNA-binding transcription factor activity
GWG05_RS00690	COG0210	DNA helicase
GWG05_RS00705	COG1943	Transposase
GWG05_RS00710	COG0583	DNA-binding transcription factor activity
GWG05_RS00750	COG1280	lysine exporter protein (LysE YggA)
GWG05_RS00760	COG2962	Rard protein
GWG05_RS00770	COG1012	belongs to the aldehyde dehydrogenase family
GWG05_RS00775	COG1396	sequence-specific DNA binding
GWG05_RS00790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWG05_RS00790	COG0519	Catalyzes the synthesis of GMP from XMP
GWG05_RS00800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWG05_RS00820	COG1322	Protein conserved in bacteria
GWG05_RS00825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWG05_RS00830	COG0569	domain protein
GWG05_RS00835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWG05_RS00835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWG05_RS00840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GWG05_RS00845	COG0242	peptide deformylase activity
GWG05_RS00855	COG0758	DNA mediated transformation
GWG05_RS00860	COG2922	Belongs to the Smg family
GWG05_RS00865	COG0551	DNA topoisomerase type I activity
GWG05_RS00870	COG0009	L-threonylcarbamoyladenylate synthase
GWG05_RS00875	COG0408	coproporphyrinogen oxidase activity
GWG05_RS00880	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GWG05_RS00885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GWG05_RS00895	COG3078	GTPase activator activity
GWG05_RS00910	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GWG05_RS00920	COG3852	Histidine kinase
GWG05_RS00930	COG0174	glutamine synthetase
GWG05_RS00940	COG1295	ribonuclease BN
GWG05_RS00945	COG1490	D-aminoacyl-tRNA deacylase activity
GWG05_RS00955	COG0456	acetyltransferase
GWG05_RS00965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWG05_RS00970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWG05_RS00975	COG2610	gluconate transmembrane transporter activity
GWG05_RS00980	COG3265	gluconokinase activity
GWG05_RS00985	COG0129	dihydroxy-acid dehydratase activity
GWG05_RS00990	COG0800	Aldolase
GWG05_RS01005	COG1609	Transcriptional regulator
GWG05_RS01015	COG4942	peptidase
GWG05_RS01020	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GWG05_RS01025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWG05_RS01030	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GWG05_RS01035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GWG05_RS01040	COG0316	Belongs to the HesB IscA family
GWG05_RS01040	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GWG05_RS01045	COG1040	competence protein
GWG05_RS01050	COG0596	Alpha beta hydrolase
GWG05_RS01065	COG2183	response to ionizing radiation
GWG05_RS01070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWG05_RS01075	COG0745	RESPONSE REGULATOR receiver
GWG05_RS01080	COG2205	protein histidine kinase activity
GWG05_RS01090	COG0051	transcription antitermination factor activity, RNA binding
GWG05_RS01095	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GWG05_RS01100	COG0088	Forms part of the polypeptide exit tunnel
GWG05_RS01105	COG0089	rRNA binding
GWG05_RS01110	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GWG05_RS01115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GWG05_RS01120	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GWG05_RS01125	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GWG05_RS01130	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GWG05_RS01135	COG0255	Belongs to the universal ribosomal protein uL29 family
GWG05_RS01140	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GWG05_RS01145	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GWG05_RS01150	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GWG05_RS01155	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GWG05_RS01160	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GWG05_RS01165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GWG05_RS01170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GWG05_RS01175	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GWG05_RS01180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GWG05_RS01185	COG1841	ribosomal large subunit assembly
GWG05_RS01190	COG0200	Binds to the 23S rRNA
GWG05_RS01195	COG0201	protein transport
GWG05_RS01200	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWG05_RS01205	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GWG05_RS01210	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GWG05_RS01215	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GWG05_RS01220	COG0202	RNA polymerase activity
GWG05_RS01225	COG0203	ribosomal protein L17
GWG05_RS01280	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWG05_RS01285	COG0583	DNA-binding transcription factor activity
GWG05_RS01290	COG4221	oxidoreductase activity
GWG05_RS01305	COG1770	oligopeptidase
GWG05_RS01310	COG2358	TRAP transporter, solute receptor (TAXI family
GWG05_RS01325	COG3714	YhhN family
GWG05_RS01340	COG0583	DNA-binding transcription factor activity
GWG05_RS01350	COG1301	dicarboxylic acid transport
GWG05_RS01360	COG2095	MarC family integral membrane protein
GWG05_RS01370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWG05_RS01380	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GWG05_RS01390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWG05_RS01415	COG0742	ribosomal rna small subunit methyltransferase
GWG05_RS01420	COG0552	protein localization to endoplasmic reticulum
GWG05_RS01425	COG2884	Cell division ATP-binding protein ftsE
GWG05_RS01430	COG2177	Part of the ABC transporter FtsEX involved in
GWG05_RS01440	COG0288	reversible hydration of carbon dioxide
GWG05_RS01445	COG2188	Transcriptional regulator
GWG05_RS01450	COG1228	amidohydrolase
GWG05_RS01455	COG0010	Belongs to the arginase family
GWG05_RS01460	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GWG05_RS01465	COG2986	histidine ammonia-lyase
GWG05_RS01470	COG0387	Pfam Sodium calcium exchanger
GWG05_RS01475	COG2200	EAL domain
GWG05_RS01530	COG1459	type II secretion system
GWG05_RS01545	COG4969	Belongs to the N-Me-Phe pilin family
GWG05_RS01550	COG4968	Prepilin-type N-terminal cleavage methylation domain
GWG05_RS01575	COG1077	Cell shape determining protein MreB Mrl
GWG05_RS01580	COG1792	Involved in formation and maintenance of cell shape
GWG05_RS01585	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GWG05_RS01590	COG0424	maF-like protein
GWG05_RS01595	COG1530	ribonuclease E activity
GWG05_RS01600	COG3164	Protein of unknown function
GWG05_RS01605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWG05_RS01610	COG0312	modulator of DNA gyrase
GWG05_RS01630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWG05_RS01630	COG1263	PTS System
GWG05_RS01635	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GWG05_RS01650	COG0477	Major facilitator Superfamily
GWG05_RS01660	COG2321	neutral zinc metallopeptidase
GWG05_RS01695	COG0189	ligase activity
GWG05_RS01700	COG0642	Histidine kinase
GWG05_RS01705	COG0745	RESPONSE REGULATOR receiver
GWG05_RS01720	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GWG05_RS01725	COG0352	thiamine-phosphate diphosphorylase activity
GWG05_RS01730	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWG05_RS01740	COG2022	thiamine diphosphate biosynthetic process
GWG05_RS01745	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GWG05_RS01760	COG0110	maltose O-acetyltransferase activity
GWG05_RS01770	COG2203	Gaf domain
GWG05_RS01770	COG2199	diguanylate cyclase activity
GWG05_RS01775	COG3932	Exopolysaccharide synthesis, ExoD
GWG05_RS01795	COG1733	regulation of RNA biosynthetic process
GWG05_RS01825	COG1494	fructose-1,6-bisphosphatase
GWG05_RS01835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GWG05_RS01840	COG5007	Belongs to the BolA IbaG family
GWG05_RS01850	COG2854	intermembrane phospholipid transfer
GWG05_RS01855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GWG05_RS01860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GWG05_RS01865	COG1127	ABC transporter
GWG05_RS01870	COG0517	IMP dehydrogenase activity
GWG05_RS01870	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GWG05_RS01875	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GWG05_RS01885	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GWG05_RS01890	COG1137	ATPase activity
GWG05_RS01895	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GWG05_RS01905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWG05_RS01910	COG1660	Displays ATPase and GTPase activities
GWG05_RS01915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWG05_RS01935	COG3964	amidohydrolase
GWG05_RS01965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWG05_RS01970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWG05_RS01980	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GWG05_RS01985	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GWG05_RS01990	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GWG05_RS01995	COG0723	plastoquinol--plastocyanin reductase activity
GWG05_RS02000	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GWG05_RS02005	COG2857	Cytochrome c1
GWG05_RS02010	COG0625	glutathione transferase activity
GWG05_RS02015	COG2969	positive regulation of protein catabolic process
GWG05_RS02020	COG2823	Periplasmic or secreted lipoprotein
GWG05_RS02025	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GWG05_RS02030	COG0792	nuclease activity
GWG05_RS02035	COG3107	peptidoglycan biosynthetic process
GWG05_RS02040	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GWG05_RS02050	COG2001	Belongs to the MraZ family
GWG05_RS02055	COG0275	rRNA processing
GWG05_RS02060	COG3116	cell division
GWG05_RS02065	COG0768	penicillin binding
GWG05_RS02070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GWG05_RS02075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GWG05_RS02080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWG05_RS02085	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GWG05_RS02090	COG0772	Belongs to the SEDS family
GWG05_RS02095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWG05_RS02100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWG05_RS02105	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GWG05_RS02110	COG0849	cell division
GWG05_RS02115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GWG05_RS02120	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GWG05_RS02130	COG0653	protein targeting
GWG05_RS02140	COG0494	nUDIX hydrolase
GWG05_RS02145	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GWG05_RS02150	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GWG05_RS02160	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GWG05_RS02165	COG1459	type II secretion system
GWG05_RS02170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWG05_RS02195	COG2186	Transcriptional regulator
GWG05_RS02200	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GWG05_RS02205	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWG05_RS02210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWG05_RS02220	COG0840	transmembrane signaling receptor activity
GWG05_RS02225	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWG05_RS02230	COG1049	propionate catabolic process, 2-methylcitrate cycle
GWG05_RS02245	COG1280	lysine exporter protein (LysE YggA)
GWG05_RS02255	COG0523	cobalamin synthesis protein
GWG05_RS02260	COG0477	Major facilitator Superfamily
GWG05_RS02275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GWG05_RS02280	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GWG05_RS02325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GWG05_RS02335	COG1546	Belongs to the CinA family
GWG05_RS02340	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GWG05_RS02345	COG2137	regulation of response to DNA damage stimulus
GWG05_RS02350	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWG05_RS02355	COG0527	aspartate kinase activity
GWG05_RS02360	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GWG05_RS02395	COG1686	Belongs to the peptidase S11 family
GWG05_RS02400	COG0586	Pfam SNARE associated Golgi protein
GWG05_RS02405	COG1253	flavin adenine dinucleotide binding
GWG05_RS02410	COG0525	valine-tRNA ligase activity
GWG05_RS02420	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GWG05_RS02425	COG0795	lipopolysaccharide-transporting ATPase activity
GWG05_RS02430	COG0795	lipopolysaccharide-transporting ATPase activity
GWG05_RS02450	COG0004	ammonium transporteR
GWG05_RS02455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWG05_RS02470	COG4968	Prepilin-type N-terminal cleavage methylation domain
GWG05_RS02475	COG0084	hydrolase, TatD family'
GWG05_RS02480	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWG05_RS02490	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GWG05_RS02495	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GWG05_RS02500	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GWG05_RS02505	COG0813	purine-nucleoside phosphorylase activity
GWG05_RS02510	COG3447	MASE1 domain protein
GWG05_RS02510	COG5002	protein histidine kinase activity
GWG05_RS02510	COG5001	Diguanylate cyclase
GWG05_RS02520	COG0560	Phosphoserine phosphatase
GWG05_RS02535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GWG05_RS02545	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GWG05_RS02550	COG0776	regulation of translation
GWG05_RS02565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWG05_RS02570	COG0735	belongs to the Fur family
GWG05_RS02590	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GWG05_RS02595	COG0513	Belongs to the DEAD box helicase family
GWG05_RS02600	COG3022	response to hydroperoxide
GWG05_RS02605	COG2805	Type II/IV secretion system protein
GWG05_RS02615	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWG05_RS02620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GWG05_RS02625	COG0762	integral membrane protein
GWG05_RS02630	COG1872	DUF167
GWG05_RS02650	COG3112	Uncharacterised protein family (UPF0231)
GWG05_RS02655	COG3835	regulator
GWG05_RS02660	COG2610	gluconate transmembrane transporter activity
GWG05_RS02665	COG1929	Belongs to the glycerate kinase type-1 family
GWG05_RS02680	COG0583	DNA-binding transcription factor activity
GWG05_RS02685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWG05_RS02700	COG0347	Belongs to the P(II) protein family
GWG05_RS02715	COG3842	ATPase activity
GWG05_RS02720	COG2837	iron assimilation
GWG05_RS02725	COG1438	arginine binding
GWG05_RS02730	COG1126	abc transporter atp-binding protein
GWG05_RS02735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG05_RS02740	COG4215	(ABC) transporter
GWG05_RS02745	COG4160	amino acid transport
GWG05_RS02750	COG0039	L-malate dehydrogenase activity
GWG05_RS02755	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GWG05_RS02760	COG1017	nitric oxide dioxygenase activity
GWG05_RS02760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWG05_RS02770	COG4536	flavin adenine dinucleotide binding
GWG05_RS02775	COG4137	Cytochrome C assembly protein
GWG05_RS02780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWG05_RS02785	COG0228	four-way junction DNA binding
GWG05_RS02790	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GWG05_RS02795	COG0336	Belongs to the RNA methyltransferase TrmD family
GWG05_RS02800	COG0335	large ribosomal subunit rRNA binding
GWG05_RS02815	COG1051	belongs to the nudix hydrolase family
GWG05_RS02825	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GWG05_RS02830	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GWG05_RS02835	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GWG05_RS02845	COG0583	DNA-binding transcription factor activity
GWG05_RS02850	COG0640	Transcriptional regulator
GWG05_RS02855	COG0268	Binds directly to 16S ribosomal RNA
GWG05_RS02860	COG0728	peptidoglycan biosynthetic process
GWG05_RS02865	COG0196	riboflavin kinase activity
GWG05_RS02870	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GWG05_RS02875	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GWG05_RS02880	COG1047	Peptidyl-prolyl cis-trans
GWG05_RS02885	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GWG05_RS02925	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GWG05_RS02925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWG05_RS02940	COG1854	S-ribosylhomocysteine lyase activity
GWG05_RS02945	COG3706	GGDEF domain
GWG05_RS02950	COG0557	exoribonuclease II activity
GWG05_RS02955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWG05_RS02965	COG2153	protein acetylation
GWG05_RS02975	COG1914	H( )-stimulated, divalent metal cation uptake system
GWG05_RS02980	COG0360	Binds together with S18 to 16S ribosomal RNA
GWG05_RS02985	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GWG05_RS02990	COG0359	binds to the 23S rRNA
GWG05_RS03025	COG1238	metal cluster binding
GWG05_RS03030	COG0612	Peptidase, M16
GWG05_RS03035	COG2918	glutathione biosynthetic process
GWG05_RS03040	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GWG05_RS03045	COG1027	Aspartate ammonia-lyase
GWG05_RS03050	COG3030	protein affecting phage T7 exclusion by the F plasmid
GWG05_RS03055	COG0534	Mate efflux family protein
GWG05_RS03060	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GWG05_RS03065	COG0459	protein refolding
GWG05_RS03085	COG0564	pseudouridine synthase activity
GWG05_RS03090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWG05_RS03120	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GWG05_RS03130	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GWG05_RS03135	COG4208	sulfate ABC transporter
GWG05_RS03140	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GWG05_RS03145	COG0583	DNA-binding transcription factor activity
GWG05_RS03150	COG3397	chitin binding
GWG05_RS03180	COG1328	CTP reductase activity
GWG05_RS03185	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GWG05_RS03200	COG1448	Aminotransferase
GWG05_RS03225	COG1215	transferase activity, transferring glycosyl groups
GWG05_RS03230	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GWG05_RS03235	COG3118	belongs to the thioredoxin family
GWG05_RS03235	COG0457	Tetratricopeptide repeat
GWG05_RS03270	COG0513	Belongs to the DEAD box helicase family
GWG05_RS03275	COG0840	transmembrane signaling receptor activity
GWG05_RS03285	COG4166	transmembrane transport
GWG05_RS03300	COG1024	Enoyl-CoA hydratase
GWG05_RS03315	COG4221	oxidoreductase activity
GWG05_RS03320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWG05_RS03325	COG0442	prolyl-tRNA aminoacylation
GWG05_RS03330	COG0840	transmembrane signaling receptor activity
GWG05_RS03335	COG0632	four-way junction helicase activity
GWG05_RS03340	COG2255	four-way junction helicase activity
GWG05_RS03350	COG1271	oxidase subunit
GWG05_RS03355	COG1294	oxidase, subunit
GWG05_RS03360	COG4890	Cyd operon protein YbgT
GWG05_RS03365	COG3790	cyd operon protein YbgE
GWG05_RS03370	COG0824	Thioesterase
GWG05_RS03375	COG0811	peptide transport
GWG05_RS03390	COG0823	Involved in the tonB-independent uptake of proteins
GWG05_RS03395	COG2885	chlorophyll binding
GWG05_RS03400	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GWG05_RS03475	COG0840	transmembrane signaling receptor activity
GWG05_RS03480	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GWG05_RS03490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWG05_RS03495	COG1640	4-alpha-glucanotransferase
GWG05_RS03500	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GWG05_RS03525	COG1051	belongs to the nudix hydrolase family
GWG05_RS03530	COG2130	NADP-dependent
GWG05_RS03535	COG1846	Transcriptional regulator
GWG05_RS03565	COG0561	phosphatase activity
GWG05_RS03580	COG0733	neurotransmitter:sodium symporter activity
GWG05_RS03585	COG0733	neurotransmitter:sodium symporter activity
GWG05_RS03600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWG05_RS03615	COG1794	racemase activity, acting on amino acids and derivatives
GWG05_RS03625	COG1022	Amp-dependent synthetase and ligase
GWG05_RS03635	COG0456	acetyltransferase
GWG05_RS03650	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GWG05_RS03655	COG5002	protein histidine kinase activity
GWG05_RS03655	COG5001	Diguanylate cyclase
GWG05_RS03675	COG0456	acetyltransferase
GWG05_RS03685	COG0456	acetyltransferase
GWG05_RS03690	COG1902	pentaerythritol trinitrate reductase activity
GWG05_RS03700	COG2852	Protein conserved in bacteria
GWG05_RS03710	COG2957	Belongs to the agmatine deiminase family
GWG05_RS03715	COG0154	amidase activity
GWG05_RS03750	COG2207	Transcriptional regulator
GWG05_RS03750	COG1917	Cupin 2, conserved barrel domain protein
GWG05_RS03760	COG0513	Belongs to the DEAD box helicase family
GWG05_RS03765	COG2199	diguanylate cyclase activity
GWG05_RS03765	COG2203	Gaf domain
GWG05_RS03800	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
GWG05_RS03810	COG0577	efflux transmembrane transporter activity
GWG05_RS03810	COG1136	(ABC) transporter
GWG05_RS03815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG05_RS03820	COG0745	RESPONSE REGULATOR receiver
GWG05_RS03825	COG2205	protein histidine kinase activity
GWG05_RS03875	COG1280	lysine exporter protein (LysE YggA)
GWG05_RS03880	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GWG05_RS03895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG05_RS03925	COG0745	RESPONSE REGULATOR receiver
GWG05_RS03930	COG3104	oligopeptide transport
GWG05_RS03935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWG05_RS03940	COG1555	photosystem II stabilization
GWG05_RS03950	COG2350	Protein conserved in bacteria
GWG05_RS03955	COG2917	probably involved in intracellular septation
GWG05_RS03960	COG0076	glutamate decarboxylase activity
GWG05_RS03965	COG1272	protein, Hemolysin III
GWG05_RS03970	COG2985	domain, Protein
GWG05_RS03970	COG0569	domain protein
GWG05_RS03980	COG0477	Major facilitator Superfamily
GWG05_RS03985	COG0583	DNA-binding transcription factor activity
GWG05_RS03990	COG3227	Zinc metalloprotease (Elastase)
GWG05_RS03995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWG05_RS04000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWG05_RS04010	COG2731	YhcH YjgK YiaL family protein
GWG05_RS04020	COG0668	transmembrane transport
GWG05_RS04030	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWG05_RS04040	COG0789	Transcriptional regulator
GWG05_RS04055	COG3039	Transposase
GWG05_RS04065	COG3039	Transposase
GWG05_RS04105	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GWG05_RS04115	COG0488	(ABC) transporter
GWG05_RS04120	COG0516	GMP reductase activity
GWG05_RS04120	COG0517	IMP dehydrogenase activity
GWG05_RS04130	COG0784	Response regulator, receiver
GWG05_RS04130	COG0835	chemotaxis
GWG05_RS04135	COG2755	lipolytic protein G-D-S-L family
GWG05_RS04140	COG4181	ATPase activity
GWG05_RS04145	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GWG05_RS04150	COG1090	epimerase
GWG05_RS04155	COG2200	EAL domain
GWG05_RS04160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWG05_RS04165	COG2234	aminopeptidase activity
GWG05_RS04165	COG4935	Belongs to the peptidase S8 family
GWG05_RS04170	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GWG05_RS04175	COG3171	Protein conserved in bacteria
GWG05_RS04180	COG2066	Belongs to the glutaminase family
GWG05_RS04185	COG2897	thiosulfate sulfurtransferase activity
GWG05_RS04195	COG1132	(ABC) transporter
GWG05_RS04220	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
GWG05_RS04225	COG5001	Diguanylate cyclase
GWG05_RS04225	COG3300	MHYT domain
GWG05_RS04245	COG4628	conserved protein (DUF2132)
GWG05_RS04250	COG0688	phosphatidylethanolamine metabolic process
GWG05_RS04255	COG1162	GTPase activity
GWG05_RS04260	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GWG05_RS04300	COG1278	Cold shock
GWG05_RS04310	COG0840	transmembrane signaling receptor activity
GWG05_RS04315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWG05_RS04365	COG0848	biopolymer transport protein
GWG05_RS04370	COG0811	peptide transport
GWG05_RS04375	COG0811	peptide transport
GWG05_RS04390	COG4174	ABC transporter (Permease)
GWG05_RS04395	COG4239	(ABC) transporter, permease
GWG05_RS04405	COG0444	Belongs to the ABC transporter superfamily
GWG05_RS04410	COG4608	Belongs to the ABC transporter superfamily
GWG05_RS04415	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWG05_RS04420	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GWG05_RS04440	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GWG05_RS04465	COG0243	molybdopterin cofactor binding
GWG05_RS04470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWG05_RS04470	COG1648	precorrin-2 dehydrogenase activity
GWG05_RS04480	COG1116	anion transmembrane transporter activity
GWG05_RS04480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GWG05_RS04485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWG05_RS04490	COG1116	anion transmembrane transporter activity
GWG05_RS04495	COG2146	nitrite reductase [NAD(P)H] activity
GWG05_RS04495	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWG05_RS04500	COG2146	nitrite reductase [NAD(P)H] activity
GWG05_RS04500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWG05_RS04505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWG05_RS04510	COG2313	pseudouridylate synthase activity
GWG05_RS04515	COG2313	pseudouridylate synthase activity
GWG05_RS04540	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWG05_RS04550	COG2966	Psort location CytoplasmicMembrane, score
GWG05_RS04565	COG4175	Glycine betaine
GWG05_RS04570	COG4176	ABC-type proline glycine betaine transport system permease component
GWG05_RS04575	COG2113	Glycine betaine
GWG05_RS04580	COG0175	sulfate reduction
GWG05_RS04585	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWG05_RS04590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GWG05_RS04600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GWG05_RS04615	COG0786	glutamate:sodium symporter activity
GWG05_RS04620	COG0252	asparaginase activity
GWG05_RS04625	COG3139	Protein of unknown function (DUF1315)
GWG05_RS04645	COG0616	signal peptide processing
GWG05_RS04650	COG1902	pentaerythritol trinitrate reductase activity
GWG05_RS04650	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWG05_RS04655	COG0778	Nitroreductase
GWG05_RS04665	COG0110	maltose O-acetyltransferase activity
GWG05_RS04670	COG2264	protein methyltransferase activity
GWG05_RS04675	COG0604	alcohol dehydrogenase
GWG05_RS04680	COG0583	DNA-binding transcription factor activity
GWG05_RS04685	COG2190	(PTS) system
GWG05_RS04685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWG05_RS04685	COG1263	PTS System
GWG05_RS04690	COG4145	pantothenate transmembrane transporter activity
GWG05_RS04695	COG3924	membrane
GWG05_RS04700	COG0439	Biotin carboxylase
GWG05_RS04705	COG0511	ligase activity, forming carbon-carbon bonds
GWG05_RS04710	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GWG05_RS04715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWG05_RS04730	COG3381	protein complex oligomerization
GWG05_RS04740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GWG05_RS04750	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GWG05_RS04755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWG05_RS04755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWG05_RS04770	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GWG05_RS04775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWG05_RS04780	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GWG05_RS04785	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GWG05_RS04790	COG4172	Belongs to the ABC transporter superfamily
GWG05_RS04810	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GWG05_RS04815	COG0142	geranyltranstransferase activity
GWG05_RS04820	COG1722	exodeoxyribonuclease VII activity
GWG05_RS04825	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWG05_RS04830	COG1360	Flagellar Motor Protein
GWG05_RS04845	COG1534	Rna-binding protein
GWG05_RS04850	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GWG05_RS04860	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GWG05_RS04865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWG05_RS04870	COG0149	triose-phosphate isomerase activity
GWG05_RS04875	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWG05_RS04890	COG0779	Required for maturation of 30S ribosomal subunits
GWG05_RS04895	COG0195	Participates in both transcription termination and antitermination
GWG05_RS04900	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GWG05_RS04905	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GWG05_RS04910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GWG05_RS04915	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GWG05_RS04920	COG1185	polyribonucleotide nucleotidyltransferase activity
GWG05_RS04925	COG2211	Major facilitator Superfamily
GWG05_RS04930	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GWG05_RS04935	COG1422	Protein of unknown function (DUF1090)
GWG05_RS04940	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWG05_RS04965	COG0312	modulator of DNA gyrase
GWG05_RS04975	COG0312	modulator of DNA gyrase
GWG05_RS04985	COG4974	Belongs to the 'phage' integrase family
GWG05_RS04990	COG1970	mechanosensitive ion channel activity
GWG05_RS05005	COG0789	Transcriptional regulator
GWG05_RS05020	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWG05_RS05030	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GWG05_RS05035	COG0321	lipoyl(octanoyl) transferase activity
GWG05_RS05040	COG2921	Belongs to the UPF0250 family
GWG05_RS05045	COG1686	Belongs to the peptidase S11 family
GWG05_RS05050	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GWG05_RS05055	COG2951	lytic endotransglycosylase activity
GWG05_RS05060	COG0772	Belongs to the SEDS family
GWG05_RS05065	COG0768	penicillin binding
GWG05_RS05070	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GWG05_RS05075	COG0799	negative regulation of ribosome biogenesis
GWG05_RS05080	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GWG05_RS05100	COG0495	leucyl-tRNA aminoacylation
GWG05_RS05105	COG2888	peptidyl-tyrosine sulfation
GWG05_RS05110	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GWG05_RS05115	COG4535	Mg2 and Co2 transporter CorC
GWG05_RS05120	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GWG05_RS05125	COG1702	phosphate starvation-inducible protein PhoH
GWG05_RS05130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWG05_RS05135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWG05_RS05140	COG1335	isochorismatase
GWG05_RS05145	COG1278	Cold shock
GWG05_RS05160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWG05_RS05165	COG2199	diguanylate cyclase activity
GWG05_RS05175	COG2199	diguanylate cyclase activity
GWG05_RS05185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWG05_RS05200	COG1464	Belongs to the NlpA lipoprotein family
GWG05_RS05205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWG05_RS05210	COG2011	ABC-type metal ion transport system permease component
GWG05_RS05215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GWG05_RS05225	COG0516	GMP reductase activity
GWG05_RS05230	COG0189	ligase activity
GWG05_RS05230	COG4067	protein conserved in archaea
GWG05_RS05250	COG0300	oxidoreductase activity
GWG05_RS05270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWG05_RS05275	COG3214	Protein conserved in bacteria
GWG05_RS05290	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GWG05_RS05295	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GWG05_RS05300	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GWG05_RS05305	COG1053	succinate dehydrogenase
GWG05_RS05315	COG0584	glycerophosphoryl diester phosphodiesterase
GWG05_RS05320	COG3264	Mechanosensitive ion channel
GWG05_RS05320	COG1511	domain protein
GWG05_RS05330	COG0739	heme binding
GWG05_RS05350	COG0583	DNA-binding transcription factor activity
GWG05_RS05365	COG0583	DNA-binding transcription factor activity
GWG05_RS05370	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GWG05_RS05400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GWG05_RS05405	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GWG05_RS05415	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GWG05_RS05420	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GWG05_RS05425	COG0546	phosphoglycolate phosphatase activity
GWG05_RS05430	COG0180	Tryptophanyl-tRNA synthetase
GWG05_RS05445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWG05_RS05455	COG1012	belongs to the aldehyde dehydrogenase family
GWG05_RS05485	COG2801	Transposase and inactivated derivatives
GWG05_RS05490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWG05_RS05515	COG0471	metal ion transport
GWG05_RS05515	COG0490	domain, Protein
GWG05_RS05560	COG0012	GTP binding
GWG05_RS05565	COG0193	aminoacyl-tRNA hydrolase activity
GWG05_RS05570	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWG05_RS05580	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GWG05_RS05585	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GWG05_RS05590	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GWG05_RS05595	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GWG05_RS05600	COG2890	protein-(glutamine-N5) methyltransferase activity
GWG05_RS05610	COG2912	Transglutaminase-like superfamily
GWG05_RS05615	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GWG05_RS05620	COG1301	dicarboxylic acid transport
GWG05_RS05630	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GWG05_RS05645	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GWG05_RS05650	COG1115	amino acid carrier protein
GWG05_RS05670	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GWG05_RS05680	COG0189	ligase activity
GWG05_RS05685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GWG05_RS05695	COG3091	SprT-like family
GWG05_RS05705	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GWG05_RS05715	COG2801	Transposase and inactivated derivatives
GWG05_RS05735	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GWG05_RS05740	COG0739	heme binding
GWG05_RS05745	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWG05_RS05750	COG3408	Glycogen debranching enzyme
GWG05_RS05750	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GWG05_RS05760	COG1881	PFAM PEBP family protein
GWG05_RS05770	COG0583	DNA-binding transcription factor activity
GWG05_RS05780	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GWG05_RS05790	COG0583	DNA-binding transcription factor activity
GWG05_RS05795	COG1028	Short-chain dehydrogenase reductase Sdr
GWG05_RS05800	COG0616	signal peptide processing
GWG05_RS05805	COG3724	N-succinylarginine dihydrolase activity
GWG05_RS05825	COG0840	transmembrane signaling receptor activity
GWG05_RS05835	COG2971	BadF BadG BcrA BcrD
GWG05_RS05845	COG4608	Belongs to the ABC transporter superfamily
GWG05_RS05850	COG0444	Belongs to the ABC transporter superfamily
GWG05_RS05855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWG05_RS05870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWG05_RS05880	COG0640	Transcriptional regulator
GWG05_RS05885	COG0798	PFAM Bile acid sodium symporter
GWG05_RS05890	COG1393	Belongs to the ArsC family
GWG05_RS05905	COG1677	Flagellar hook-basal body complex protein FliE
GWG05_RS05915	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWG05_RS05970	COG1684	flagellar biosynthetic protein fliR
GWG05_RS05980	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWG05_RS06005	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GWG05_RS06010	COG0643	Histidine kinase
GWG05_RS06010	COG0784	Response regulator, receiver
GWG05_RS06010	COG2198	Histidine kinase
GWG05_RS06020	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWG05_RS06025	COG1360	Flagellar Motor Protein
GWG05_RS06030	COG1192	Involved in chromosome partitioning
GWG05_RS06040	COG0835	chemotaxis
GWG05_RS06055	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWG05_RS06060	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWG05_RS06065	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWG05_RS06070	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GWG05_RS06075	COG1138	Cytochrome C-type biogenesis protein
GWG05_RS06080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWG05_RS06090	COG0457	Tetratricopeptide repeat
GWG05_RS06105	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GWG05_RS06110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWG05_RS06110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWG05_RS06125	COG0259	pyridoxamine-phosphate oxidase activity
GWG05_RS06155	COG3153	acetyltransferase
GWG05_RS06170	COG0800	Aldolase
GWG05_RS06175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWG05_RS06185	COG2721	sulfolactate sulfo-lyase activity
GWG05_RS06190	COG0246	Mannitol dehydrogenase
GWG05_RS06225	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GWG05_RS06230	COG2867	negative regulation of translational initiation
GWG05_RS06240	COG0702	epimerase
GWG05_RS06245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWG05_RS06255	COG2932	Transcriptional regulator
GWG05_RS06355	COG0640	Transcriptional regulator
GWG05_RS06365	COG4373	Mu-like prophage FluMu protein gp28
GWG05_RS06370	COG4383	Mu-like prophage protein gp29
GWG05_RS06395	COG4388	Caudovirus prohead serine protease
GWG05_RS06400	COG4397	Mu-like prophage major head subunit gpT
GWG05_RS06490	COG0564	pseudouridine synthase activity
GWG05_RS06495	COG1957	nucleoside hydrolase
GWG05_RS06520	COG1280	lysine exporter protein (LysE YggA)
GWG05_RS06530	COG3263	regulation of cellular component size
GWG05_RS06540	COG1876	peptidase activity
GWG05_RS06545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWG05_RS06550	COG1393	Belongs to the ArsC family
GWG05_RS06560	COG3069	C4-dicarboxylate transmembrane transporter activity
GWG05_RS06575	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GWG05_RS06580	COG0017	Asparaginyl-tRNA synthetase
GWG05_RS06600	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GWG05_RS06605	COG0156	8-amino-7-oxononanoate synthase activity
GWG05_RS06610	COG2226	methyltransferase
GWG05_RS06610	COG1073	alpha beta
GWG05_RS06615	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GWG05_RS06620	COG0501	Belongs to the peptidase M48B family
GWG05_RS06625	COG0633	Ferredoxin
GWG05_RS06625	COG3217	Mosc domain protein beta barrel domain protein
GWG05_RS06625	COG0633	Ferredoxin
GWG05_RS06625	COG3217	Mosc domain protein beta barrel domain protein
GWG05_RS06635	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GWG05_RS06635	COG0674	pyruvate-flavodoxin oxidoreductase activity
GWG05_RS06635	COG1013	pyruvate-flavodoxin oxidoreductase activity
GWG05_RS06635	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GWG05_RS06640	COG2841	Protein conserved in bacteria
GWG05_RS06650	COG0534	Mate efflux family protein
GWG05_RS06675	COG1454	alcohol dehydrogenase
GWG05_RS06685	COG1309	transcriptional regulator
GWG05_RS06700	COG0791	NLP P60 protein
GWG05_RS06705	COG0583	DNA-binding transcription factor activity
GWG05_RS06725	COG0500	methyltransferase
GWG05_RS06730	COG4106	trans-aconitate 2-methyltransferase activity
GWG05_RS06735	COG1801	Protein of unknown function DUF72
GWG05_RS06740	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GWG05_RS06745	COG0217	transcriptional regulatory protein
GWG05_RS06750	COG2194	sulfuric ester hydrolase activity
GWG05_RS06755	COG1940	carbohydrate kinase activity
GWG05_RS06755	COG1846	Transcriptional regulator
GWG05_RS06760	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWG05_RS06765	COG0363	glucosamine-6-phosphate deaminase activity
GWG05_RS06770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWG05_RS06770	COG2190	(PTS) system
GWG05_RS06770	COG1263	PTS System
GWG05_RS06780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWG05_RS06785	COG0735	belongs to the Fur family
GWG05_RS06795	COG0716	FMN binding
GWG05_RS06810	COG0596	Alpha beta hydrolase
GWG05_RS06815	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GWG05_RS06820	COG0033	Phosphoglucomutase
GWG05_RS06830	COG1846	Transcriptional regulator
GWG05_RS06835	COG2951	lytic endotransglycosylase activity
GWG05_RS06840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GWG05_RS06845	COG4136	ATPase activity
GWG05_RS06855	COG4134	Bacterial extracellular solute-binding protein
GWG05_RS06865	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWG05_RS06875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWG05_RS06885	COG0729	surface antigen
GWG05_RS06890	COG2911	Protein conserved in bacteria
GWG05_RS06905	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GWG05_RS06915	COG0741	lytic transglycosylase activity
GWG05_RS06930	COG1607	acyl-coa hydrolase
GWG05_RS06945	COG1388	LysM domain
GWG05_RS06945	COG0741	lytic transglycosylase activity
GWG05_RS06950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWG05_RS06955	COG2226	methyltransferase
GWG05_RS06960	COG0328	RNA-DNA hybrid ribonuclease activity
GWG05_RS06970	COG3039	Transposase
GWG05_RS07000	COG1484	DNA-dependent DNA replication
GWG05_RS07005	COG4584	PFAM Integrase catalytic
GWG05_RS07045	COG0659	secondary active sulfate transmembrane transporter activity
GWG05_RS07060	COG3039	Transposase
GWG05_RS07065	COG2850	peptidyl-arginine hydroxylation
GWG05_RS07090	COG1484	DNA-dependent DNA replication
GWG05_RS07175	COG4974	Belongs to the 'phage' integrase family
GWG05_RS07180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWG05_RS07195	COG1960	acyl-CoA dehydrogenase activity
GWG05_RS07200	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GWG05_RS07205	COG0121	glutamine amidotransferase
GWG05_RS07215	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GWG05_RS07240	COG2197	response regulator
GWG05_RS07245	COG3850	Histidine kinase
GWG05_RS07250	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GWG05_RS07255	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWG05_RS07255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWG05_RS07265	COG0243	molybdopterin cofactor binding
GWG05_RS07270	COG0437	4 iron, 4 sulfur cluster binding
GWG05_RS07275	COG0348	domain, Protein
GWG05_RS07285	COG3005	denitrification pathway
GWG05_RS07290	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWG05_RS07295	COG0315	cyclic pyranopterin monophosphate synthase activity
GWG05_RS07300	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GWG05_RS07305	COG0314	molybdopterin synthase activity
GWG05_RS07320	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GWG05_RS07325	COG2267	carboxylic ester hydrolase activity
GWG05_RS07330	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWG05_RS07340	COG0302	gtp cyclohydrolase
GWG05_RS07345	COG0840	transmembrane signaling receptor activity
GWG05_RS07360	COG0583	DNA-binding transcription factor activity
GWG05_RS07375	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GWG05_RS07390	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWG05_RS07395	COG1166	arginine decarboxylase activity
GWG05_RS07455	COG2801	Transposase and inactivated derivatives
GWG05_RS07465	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWG05_RS07470	COG1187	pseudouridine synthase activity
GWG05_RS07475	COG2807	transmembrane transport
GWG05_RS07485	COG0583	DNA-binding transcription factor activity
GWG05_RS07505	COG2979	Protein of unknown function (DUF533)
GWG05_RS07515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWG05_RS07520	COG1271	oxidase subunit
GWG05_RS07525	COG1294	oxidase, subunit
GWG05_RS07535	COG2814	Major facilitator Superfamily
GWG05_RS07540	COG0656	L-ascorbic acid biosynthetic process
GWG05_RS07560	COG0583	DNA-binding transcription factor activity
GWG05_RS07565	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GWG05_RS07570	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GWG05_RS07575	COG2271	Major facilitator Superfamily
GWG05_RS07580	COG1349	DNA-binding transcription factor activity
GWG05_RS07590	COG0584	glycerophosphoryl diester phosphodiesterase
GWG05_RS07595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWG05_RS07600	COG1605	Chorismate mutase
GWG05_RS07600	COG0287	Prephenate dehydrogenase
GWG05_RS07610	COG3085	chromosome segregation
GWG05_RS07615	COG4574	serine-type endopeptidase inhibitor activity
GWG05_RS07635	COG1770	oligopeptidase
GWG05_RS07640	COG4771	TonB-dependent receptor
GWG05_RS07645	COG3083	sulfuric ester hydrolase activity
GWG05_RS07650	COG3082	Protein of unknown function (DUF1414)
GWG05_RS07655	COG3081	Nucleoid-associated protein
GWG05_RS07665	COG1175	transmembrane transport
GWG05_RS07670	COG3833	ABC-type maltose transport systems, permease component
GWG05_RS07675	COG3842	ATPase activity
GWG05_RS07685	COG0596	Alpha beta hydrolase
GWG05_RS07700	COG0425	Belongs to the sulfur carrier protein TusA family
GWG05_RS07705	COG4783	chaperone-mediated protein folding
GWG05_RS07715	COG1393	Belongs to the ArsC family
GWG05_RS07740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG05_RS07745	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWG05_RS07750	COG2431	L-lysine efflux transmembrane transporter activity
GWG05_RS07760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG05_RS07770	COG4160	amino acid transport
GWG05_RS07780	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GWG05_RS07790	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWG05_RS07795	COG0628	permease
GWG05_RS07800	COG2373	Large extracellular alpha-helical protein
GWG05_RS07805	COG4953	penicillin-binding protein 1C
GWG05_RS07815	COG0301	tRNA thio-modification
GWG05_RS07815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWG05_RS07830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWG05_RS07840	COG1334	flagellar protein FlaG
GWG05_RS07875	COG2089	acid synthase
GWG05_RS07885	COG1083	cytidylyl-transferase
GWG05_RS07900	COG1028	Short-chain dehydrogenase reductase Sdr
GWG05_RS07905	COG0318	PFAM AMP-dependent synthetase and ligase
GWG05_RS07920	COG1216	Glycosyl transferase, family 2
GWG05_RS07985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GWG05_RS07990	COG1086	Polysaccharide biosynthesis protein
GWG05_RS07995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWG05_RS08005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GWG05_RS08020	COG0346	lactoylglutathione lyase activity
GWG05_RS08025	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GWG05_RS08030	COG4660	Part of a membrane complex involved in electron transport
GWG05_RS08035	COG4659	FMN binding
GWG05_RS08040	COG4658	electron transport chain
GWG05_RS08050	COG2878	Part of a membrane complex involved in electron transport
GWG05_RS08055	COG4657	Part of a membrane complex involved in electron transport
GWG05_RS08060	COG0675	Transposase, IS605 OrfB family
GWG05_RS08070	COG0697	spore germination
GWG05_RS08090	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GWG05_RS08095	COG1288	antiporter activity
GWG05_RS08100	COG0436	Aminotransferase
GWG05_RS08110	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GWG05_RS08115	COG2027	D-alanyl-D-alanine carboxypeptidase
GWG05_RS08120	COG1061	Type III restriction enzyme res subunit
GWG05_RS08125	COG1566	PFAM secretion protein HlyD family protein
GWG05_RS08135	COG1966	Carbon starvation protein
GWG05_RS08140	COG3279	Response regulator of the LytR AlgR family
GWG05_RS08145	COG3275	phosphorelay sensor kinase activity
GWG05_RS08155	COG1012	belongs to the aldehyde dehydrogenase family
GWG05_RS08155	COG1454	alcohol dehydrogenase
GWG05_RS08160	COG2095	MarC family integral membrane protein
GWG05_RS08170	COG0601	transmembrane transport
GWG05_RS08175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWG05_RS08180	COG0444	Belongs to the ABC transporter superfamily
GWG05_RS08190	COG0861	Integral membrane protein TerC family
GWG05_RS08195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWG05_RS08205	COG1301	dicarboxylic acid transport
GWG05_RS08225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GWG05_RS08240	COG0537	adenosine 5'-monophosphoramidase activity
GWG05_RS08275	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWG05_RS08280	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWG05_RS08295	COG2354	Protein conserved in bacteria
GWG05_RS08300	COG1164	Oligoendopeptidase f
GWG05_RS08305	COG1164	Oligoendopeptidase f
GWG05_RS08310	COG3150	esterase
GWG05_RS08315	COG1252	NADH dehydrogenase
GWG05_RS08320	COG0393	Putative heavy-metal-binding
GWG05_RS08325	COG1368	sulfuric ester hydrolase activity
GWG05_RS08335	COG0527	aspartate kinase activity
GWG05_RS08340	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GWG05_RS08340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWG05_RS08345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWG05_RS08370	COG0583	DNA-binding transcription factor activity
GWG05_RS08375	COG1620	l-lactate permease
GWG05_RS08380	COG0247	lactate metabolic process
GWG05_RS08385	COG1139	Iron-sulfur cluster binding protein
GWG05_RS08410	COG1136	(ABC) transporter
GWG05_RS08430	COG2814	Major facilitator Superfamily
GWG05_RS08455	COG0672	)-iron permease
GWG05_RS08490	COG2308	Evidence 4 Homologs of previously reported genes of
GWG05_RS08505	COG0659	secondary active sulfate transmembrane transporter activity
GWG05_RS08525	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GWG05_RS08530	COG0326	Molecular chaperone. Has ATPase activity
GWG05_RS08535	COG0563	adenylate kinase activity
GWG05_RS08540	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GWG05_RS08545	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GWG05_RS08550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWG05_RS08555	COG0840	transmembrane signaling receptor activity
GWG05_RS08570	COG3300	MHYT domain
GWG05_RS08570	COG5001	Diguanylate cyclase
GWG05_RS08595	COG1021	2,3-dihydroxybenzoate-AMP ligase
GWG05_RS08600	COG1535	isochorismatase
GWG05_RS08600	COG3433	isochorismatase activity
GWG05_RS08605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWG05_RS08610	COG1028	Short-chain dehydrogenase reductase Sdr
GWG05_RS08620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWG05_RS08635	COG1120	ATPase activity
GWG05_RS08640	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWG05_RS08645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWG05_RS08650	COG4771	TonB-dependent receptor
GWG05_RS08690	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GWG05_RS08695	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GWG05_RS08700	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWG05_RS08705	COG0861	Integral membrane protein TerC family
GWG05_RS08720	COG1022	Amp-dependent synthetase and ligase
GWG05_RS08725	COG0295	cytidine deaminase activity
GWG05_RS08730	COG1346	cytolysis
GWG05_RS08735	COG1380	Effector of murein hydrolase LrgA
GWG05_RS08740	COG3345	alpha-galactosidase
GWG05_RS08750	COG2925	Exonuclease
GWG05_RS08755	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWG05_RS08760	COG0392	lysyltransferase activity
GWG05_RS08760	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GWG05_RS08775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWG05_RS08780	COG0436	Aminotransferase
GWG05_RS08785	COG0583	DNA-binding transcription factor activity
GWG05_RS08790	COG2160	L-arabinose isomerase activity
GWG05_RS08800	COG1069	ribulokinase activity
GWG05_RS08805	COG1879	ABC-type sugar transport system periplasmic component
GWG05_RS08810	COG1129	ABC transporter
GWG05_RS08815	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWG05_RS08825	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWG05_RS08830	COG0254	rRNA binding
GWG05_RS08845	COG1451	nucleotide metabolic process
GWG05_RS08860	COG3069	C4-dicarboxylate transmembrane transporter activity
GWG05_RS08870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWG05_RS08870	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GWG05_RS08875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWG05_RS08895	COG2009	succinate dehydrogenase
GWG05_RS08900	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GWG05_RS08915	COG0567	Dehydrogenase, E1 component
GWG05_RS08920	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWG05_RS08925	COG0045	succinate-CoA ligase (ADP-forming) activity
GWG05_RS08930	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GWG05_RS08935	COG2801	Transposase and inactivated derivatives
GWG05_RS08950	COG2983	Belongs to the UPF0260 family
GWG05_RS08955	COG1882	Formate acetyltransferase
GWG05_RS08960	COG2116	formate transmembrane transporter activity
GWG05_RS08965	COG1944	ATP diphosphatase activity
GWG05_RS08975	COG2076	Multidrug Resistance protein
GWG05_RS08980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GWG05_RS08985	COG1278	Cold shock
GWG05_RS08990	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GWG05_RS08995	COG0542	response to heat
GWG05_RS09000	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GWG05_RS09005	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GWG05_RS09010	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GWG05_RS09015	COG3134	Outer membrane lipoprotein
GWG05_RS09020	COG3706	GGDEF domain
GWG05_RS09025	COG0492	ferredoxin-NADP+ reductase activity
GWG05_RS09030	COG0686	Belongs to the AlaDH PNT family
GWG05_RS09040	COG1674	ftsk spoiiie
GWG05_RS09040	COG0531	amino acid
GWG05_RS09045	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWG05_RS09050	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GWG05_RS09055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GWG05_RS09060	COG1286	toxin biosynthetic process
GWG05_RS09065	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GWG05_RS09070	COG2723	6-phospho-beta-galactosidase activity
GWG05_RS09075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWG05_RS09075	COG1263	PTS System
GWG05_RS09080	COG1609	Transcriptional regulator
GWG05_RS09090	COG4172	Belongs to the ABC transporter superfamily
GWG05_RS09100	COG4171	peptide transport system, permease
GWG05_RS09115	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GWG05_RS09120	COG1842	Phage shock protein A
GWG05_RS09135	COG3106	COG3106 Predicted ATPase
GWG05_RS09140	COG3768	UPF0283 membrane protein
GWG05_RS09150	COG2154	pterin-4-alpha-carbinolamine dehydratase
GWG05_RS09170	COG2885	chlorophyll binding
GWG05_RS09180	COG1570	exodeoxyribonuclease VII activity
GWG05_RS09190	COG1874	Beta-galactosidase
GWG05_RS09190	COG0366	Alpha amylase catalytic
GWG05_RS09200	COG0516	GMP reductase activity
GWG05_RS09200	COG0517	IMP dehydrogenase activity
GWG05_RS09205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWG05_RS09205	COG0519	Catalyzes the synthesis of GMP from XMP
GWG05_RS09210	COG3039	Transposase
GWG05_RS09235	COG1846	Transcriptional regulator
GWG05_RS09245	COG0500	methyltransferase
GWG05_RS09255	COG2062	phosphohistidine phosphatase, SixA
GWG05_RS09265	COG0697	spore germination
GWG05_RS09280	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GWG05_RS09285	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GWG05_RS09295	COG4591	ABC-type transport system involved in lipoprotein release permease component
GWG05_RS09300	COG1136	(ABC) transporter
GWG05_RS09305	COG4591	ABC-type transport system involved in lipoprotein release permease component
GWG05_RS09310	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GWG05_RS09320	COG0544	peptidyl-prolyl cis-trans isomerase activity
GWG05_RS09325	COG0740	serine-type endopeptidase activity
GWG05_RS09330	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GWG05_RS09335	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GWG05_RS09340	COG0776	regulation of translation
GWG05_RS09345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWG05_RS09350	COG0488	(ABC) transporter
GWG05_RS09355	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWG05_RS09360	COG3162	membrane
GWG05_RS09375	COG1024	Enoyl-CoA hydratase
GWG05_RS09380	COG1115	amino acid carrier protein
GWG05_RS09390	COG3228	Belongs to the MtfA family
GWG05_RS09395	COG1584	GPR1 FUN34 yaaH family protein
GWG05_RS09420	COG1024	Enoyl-CoA hydratase
GWG05_RS09425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWG05_RS09430	COG1960	acyl-CoA dehydrogenase activity
GWG05_RS09440	COG1960	acyl-CoA dehydrogenase activity
GWG05_RS09445	COG1024	Enoyl-CoA hydratase
GWG05_RS09450	COG1024	Enoyl-CoA hydratase
GWG05_RS09460	COG1028	Short-chain dehydrogenase reductase Sdr
GWG05_RS09470	COG0730	response to heat
GWG05_RS09500	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWG05_RS09550	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWG05_RS09555	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWG05_RS09560	COG1129	ABC transporter
GWG05_RS09565	COG1879	ABC-type sugar transport system periplasmic component
GWG05_RS09570	COG0583	DNA-binding transcription factor activity
GWG05_RS09585	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GWG05_RS09590	COG0243	molybdopterin cofactor binding
GWG05_RS09600	COG0583	DNA-binding transcription factor activity
GWG05_RS09605	COG2723	6-phospho-beta-galactosidase activity
GWG05_RS09615	COG0583	DNA-binding transcription factor activity
GWG05_RS09630	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GWG05_RS09635	COG0673	inositol 2-dehydrogenase activity
GWG05_RS09640	COG0583	DNA-binding transcription factor activity
GWG05_RS09650	COG1560	Kdo2-lipid A biosynthetic process
GWG05_RS09655	COG1560	Kdo2-lipid A biosynthetic process
GWG05_RS09670	COG0417	DNA replication proofreading
GWG05_RS09700	COG0534	Mate efflux family protein
GWG05_RS09710	COG0307	riboflavin synthase, alpha
GWG05_RS09725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWG05_RS09730	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GWG05_RS09765	COG0675	Transposase, IS605 OrfB family
GWG05_RS09770	COG2996	Protein conserved in bacteria
GWG05_RS09785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWG05_RS09790	COG3099	Belongs to the UPF0263 family
GWG05_RS09795	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GWG05_RS09800	COG2894	cell division
GWG05_RS09805	COG0850	regulation of cytokinetic process
GWG05_RS09810	COG3100	YcgL domain-containing protein
GWG05_RS09815	COG2951	lytic endotransglycosylase activity
GWG05_RS09820	COG1760	l-serine dehydratase
GWG05_RS09825	COG1760	l-serine dehydratase
GWG05_RS09830	COG3123	guanosine phosphorylase activity
GWG05_RS09835	COG1301	dicarboxylic acid transport
GWG05_RS09850	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GWG05_RS09855	COG2067	long-chain fatty acid transport protein
GWG05_RS09860	COG2067	long-chain fatty acid transport protein
GWG05_RS09870	COG1595	DNA-templated transcription, initiation
GWG05_RS09900	COG0714	Associated with various cellular activities
GWG05_RS09905	COG0183	Belongs to the thiolase family
GWG05_RS09910	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWG05_RS09910	COG1024	Enoyl-CoA hydratase
GWG05_RS09920	COG4681	YaeQ
GWG05_RS09940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWG05_RS09955	COG3134	Outer membrane lipoprotein
GWG05_RS09960	COG0318	PFAM AMP-dependent synthetase and ligase
GWG05_RS09980	COG0140	phosphoribosyl-ATP diphosphatase activity
GWG05_RS09980	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GWG05_RS09985	COG0107	imidazoleglycerol-phosphate synthase activity
GWG05_RS09990	COG2198	Histidine kinase
GWG05_RS09990	COG2205	protein histidine kinase activity
GWG05_RS09990	COG0784	Response regulator, receiver
GWG05_RS10000	COG3437	response regulator, receiver
GWG05_RS10005	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GWG05_RS10010	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GWG05_RS10015	COG0131	Imidazoleglycerol-phosphate dehydratase
GWG05_RS10015	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GWG05_RS10020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GWG05_RS10025	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GWG05_RS10030	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GWG05_RS10040	COG1199	ATP-dependent helicase activity
GWG05_RS10045	COG1214	PFAM Peptidase M22, glycoprotease
GWG05_RS10055	COG0596	Alpha beta hydrolase
GWG05_RS10060	COG0318	PFAM AMP-dependent synthetase and ligase
GWG05_RS10075	COG0697	spore germination
GWG05_RS10085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWG05_RS10090	COG2832	Protein of unknown function (DUF454)
GWG05_RS10095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GWG05_RS10105	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GWG05_RS10110	COG0583	DNA-binding transcription factor activity
GWG05_RS10175	COG2197	response regulator
GWG05_RS10180	COG0617	tRNA 3'-terminal CCA addition
GWG05_RS10180	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GWG05_RS10180	COG0517	IMP dehydrogenase activity
GWG05_RS10185	COG1643	Atp-dependent helicase
GWG05_RS10195	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GWG05_RS10210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWG05_RS10215	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GWG05_RS10220	COG0709	Synthesizes selenophosphate from selenide and ATP
GWG05_RS10235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GWG05_RS10240	COG0840	transmembrane signaling receptor activity
GWG05_RS10245	COG1254	Belongs to the acylphosphatase family
GWG05_RS10255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWG05_RS10255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWG05_RS10260	COG0489	protein tyrosine kinase activity
GWG05_RS10265	COG0572	uridine kinase
GWG05_RS10270	COG0717	Belongs to the dCTP deaminase family
GWG05_RS10275	COG0306	phosphate transporter
GWG05_RS10280	COG1530	ribonuclease E activity
GWG05_RS10285	COG0564	pseudouridine synthase activity
GWG05_RS10300	COG1399	metal-binding, possibly nucleic acid-binding protein
GWG05_RS10305	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GWG05_RS10310	COG0416	fatty acid biosynthetic process
GWG05_RS10315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWG05_RS10325	COG1028	Short-chain dehydrogenase reductase Sdr
GWG05_RS10330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWG05_RS10335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWG05_RS10340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GWG05_RS10345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GWG05_RS10350	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GWG05_RS10355	COG0470	DNA polymerase III
GWG05_RS10360	COG0084	hydrolase, TatD family'
GWG05_RS10425	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GWG05_RS10425	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWG05_RS10430	COG3008	intermembrane lipid transfer
GWG05_RS10435	COG2995	paraquat-inducible protein a
GWG05_RS10445	COG3141	response to X-ray
GWG05_RS10470	COG1074	ATP-dependent DNA helicase activity
GWG05_RS10490	COG0583	DNA-binding transcription factor activity
GWG05_RS10515	COG0633	Ferredoxin
GWG05_RS10520	COG0789	Transcriptional regulator
GWG05_RS10530	COG0640	Transcriptional regulator
GWG05_RS10535	COG2814	Major facilitator Superfamily
GWG05_RS10540	COG1937	Protein conserved in bacteria
GWG05_RS10545	COG1230	cation diffusion facilitator family transporter
GWG05_RS10550	COG0640	Transcriptional regulator
GWG05_RS10560	COG1484	DNA-dependent DNA replication
GWG05_RS10565	COG4584	PFAM Integrase catalytic
GWG05_RS10620	COG5499	transcription regulator containing HTH domain
GWG05_RS10635	COG0789	Transcriptional regulator
GWG05_RS10660	COG1067	ATP-dependent peptidase activity
GWG05_RS10665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWG05_RS10690	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GWG05_RS10690	COG0116	Belongs to the methyltransferase superfamily
GWG05_RS10700	COG0167	dihydroorotate dehydrogenase activity
GWG05_RS10705	COG2902	Dehydrogenase
GWG05_RS10715	COG0308	aminopeptidase N
GWG05_RS10725	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GWG05_RS10730	COG1956	GAF domain-containing protein
GWG05_RS10745	COG3278	Belongs to the heme-copper respiratory oxidase family
GWG05_RS10760	COG2010	Cytochrome c
GWG05_RS10770	COG2217	Heavy metal translocating P-type atpase
GWG05_RS10785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWG05_RS10790	COG0589	response to stress
GWG05_RS10795	COG0037	tRNA processing
GWG05_RS10810	COG0625	glutathione transferase activity
GWG05_RS10815	COG1869	D-ribose catabolic process
GWG05_RS10820	COG1129	ABC transporter
GWG05_RS10825	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWG05_RS10830	COG1879	ABC-type sugar transport system periplasmic component
GWG05_RS10835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWG05_RS10840	COG1609	Transcriptional regulator
GWG05_RS10875	COG0776	regulation of translation
GWG05_RS10880	COG0072	phenylalanine-tRNA ligase activity
GWG05_RS10880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWG05_RS10885	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GWG05_RS10890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GWG05_RS10895	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GWG05_RS10900	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GWG05_RS10905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GWG05_RS10940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWG05_RS10950	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWG05_RS10955	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWG05_RS10960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWG05_RS10965	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GWG05_RS10970	COG3313	Fe-S protein
GWG05_RS10975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWG05_RS10975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWG05_RS10975	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GWG05_RS10980	COG1105	Belongs to the carbohydrate kinase PfkB family
GWG05_RS10985	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWG05_RS10985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWG05_RS10990	COG1609	Transcriptional regulator
GWG05_RS10995	COG0814	amino acid
GWG05_RS11005	COG5654	RES domain protein
GWG05_RS11010	COG0513	Belongs to the DEAD box helicase family
GWG05_RS11020	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GWG05_RS11025	COG2890	protein-(glutamine-N5) methyltransferase activity
GWG05_RS11030	COG2840	Smr protein MutS2
GWG05_RS11065	COG2824	Alkylphosphonate utilization operon protein PhnA
GWG05_RS11125	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GWG05_RS11130	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GWG05_RS11140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWG05_RS11145	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GWG05_RS11155	COG0205	6-phosphofructokinase activity
GWG05_RS11160	COG1473	amidohydrolase
GWG05_RS11165	COG1011	Hydrolase
GWG05_RS11170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GWG05_RS11215	COG3593	DNA synthesis involved in DNA repair
GWG05_RS11230	COG0583	DNA-binding transcription factor activity
GWG05_RS11235	COG0730	response to heat
GWG05_RS11250	COG1181	Belongs to the D-alanine--D-alanine ligase family
GWG05_RS11260	COG0386	Belongs to the glutathione peroxidase family
GWG05_RS11265	COG0513	Belongs to the DEAD box helicase family
GWG05_RS11300	COG2329	Antibiotic biosynthesis monooxygenase
GWG05_RS11305	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GWG05_RS11335	COG2501	S4 domain
GWG05_RS11355	COG1132	(ABC) transporter
GWG05_RS11360	COG1132	(ABC) transporter
GWG05_RS11370	COG3118	belongs to the thioredoxin family
GWG05_RS11375	COG0471	metal ion transport
GWG05_RS11385	COG0058	SHG alpha-glucan phosphorylase activity
GWG05_RS11415	COG0814	amino acid
GWG05_RS11420	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GWG05_RS11425	COG0514	ATP-dependent DNA helicase (RecQ)
GWG05_RS11430	COG2766	serine protein kinase
GWG05_RS11435	COG2718	Belongs to the UPF0229 family
GWG05_RS11440	COG2719	SpoVR family
GWG05_RS11445	COG2186	Transcriptional regulator
GWG05_RS11450	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GWG05_RS11455	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GWG05_RS11460	COG0586	Pfam SNARE associated Golgi protein
GWG05_RS11470	COG0556	nucleotide-excision repair
GWG05_RS11480	COG0569	domain protein
GWG05_RS11480	COG2985	domain, Protein
GWG05_RS11485	COG0739	heme binding
GWG05_RS11485	COG0741	lytic transglycosylase activity
GWG05_RS11485	COG1196	nuclear chromosome segregation
GWG05_RS11490	COG3181	Tripartite tricarboxylate transporter family receptor
GWG05_RS11505	COG4565	transcriptional regulatory protein
GWG05_RS11510	COG3290	protein histidine kinase activity
GWG05_RS11515	COG1940	carbohydrate kinase activity
GWG05_RS11515	COG1846	Transcriptional regulator
GWG05_RS11520	COG0840	transmembrane signaling receptor activity
GWG05_RS11525	COG3012	SEC-C Motif Domain Protein
GWG05_RS11530	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GWG05_RS11535	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GWG05_RS11540	COG0247	lactate metabolic process
GWG05_RS11560	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GWG05_RS11565	COG0437	4 iron, 4 sulfur cluster binding
GWG05_RS11570	COG3301	Polysulphide reductase, NrfD
GWG05_RS11580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWG05_RS11585	COG4235	cytochrome complex assembly
GWG05_RS11585	COG3088	subunit of a heme lyase
GWG05_RS11600	COG3046	protein related to deoxyribodipyrimidine photolyase
GWG05_RS11605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWG05_RS11620	COG0517	IMP dehydrogenase activity
GWG05_RS11620	COG0617	tRNA 3'-terminal CCA addition
GWG05_RS11620	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GWG05_RS11630	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GWG05_RS11635	COG0583	DNA-binding transcription factor activity
GWG05_RS11645	COG4774	siderophore transport
GWG05_RS11650	COG2203	Gaf domain
GWG05_RS11650	COG2199	diguanylate cyclase activity
GWG05_RS11655	COG2200	EAL domain
GWG05_RS11660	COG4977	sequence-specific DNA binding
GWG05_RS11660	COG1917	Cupin 2, conserved barrel domain protein
GWG05_RS11665	COG0583	DNA-binding transcription factor activity
GWG05_RS11670	COG2910	NAD(P)H-binding
GWG05_RS11680	COG0626	cystathionine gamma-synthase activity
GWG05_RS11685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GWG05_RS11720	COG0745	RESPONSE REGULATOR receiver
GWG05_RS11730	COG3039	Transposase
GWG05_RS11740	COG3250	beta-galactosidase activity
GWG05_RS11745	COG2223	nitrite transmembrane transporter activity
GWG05_RS11765	COG1609	Transcriptional regulator
GWG05_RS11770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWG05_RS11775	COG1085	galactose-1-phosphate uridylyltransferase
GWG05_RS11780	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWG05_RS11785	COG0469	pyruvate kinase activity
GWG05_RS11840	COG5433	transposase activity
GWG05_RS11845	COG3328	transposase activity
GWG05_RS11850	COG0210	DNA helicase
GWG05_RS11860	COG3039	Transposase
GWG05_RS11945	COG3550	peptidyl-serine autophosphorylation
GWG05_RS11955	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GWG05_RS11970	COG2723	6-phospho-beta-galactosidase activity
GWG05_RS11975	COG2190	(PTS) system
GWG05_RS11975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWG05_RS11975	COG1263	PTS System
GWG05_RS11980	COG1737	Transcriptional regulator
GWG05_RS12000	COG1435	thymidine kinase activity
GWG05_RS12005	COG1757	Na H antiporter
GWG05_RS12010	COG2916	Histone family protein nucleoid-structuring protein H-NS
GWG05_RS12015	COG2096	Adenosyltransferase
GWG05_RS12020	COG3530	Putative quorum-sensing-regulated virulence factor
GWG05_RS12025	COG0602	queuosine metabolic process
GWG05_RS12030	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GWG05_RS12050	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GWG05_RS12060	COG0776	regulation of translation
GWG05_RS12065	COG0539	negative regulation of cytoplasmic translation
GWG05_RS12070	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GWG05_RS12075	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWG05_RS12100	COG0778	Nitroreductase
GWG05_RS12105	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GWG05_RS12110	COG5001	Diguanylate cyclase
GWG05_RS12110	COG3300	MHYT domain
GWG05_RS12120	COG0583	DNA-binding transcription factor activity
GWG05_RS12125	COG0745	RESPONSE REGULATOR receiver
GWG05_RS12150	COG4989	oxidoreductase activity
GWG05_RS12155	COG0724	RNA recognition motif
GWG05_RS12165	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
GWG05_RS12175	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GWG05_RS12195	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWG05_RS12200	COG1360	Flagellar Motor Protein
GWG05_RS12205	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWG05_RS12210	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWG05_RS12215	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWG05_RS12215	COG0649	NAD binding
GWG05_RS12230	COG1034	ATP synthesis coupled electron transport
GWG05_RS12235	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GWG05_RS12240	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWG05_RS12245	COG0839	Belongs to the complex I subunit 6 family
GWG05_RS12250	COG0713	ATP synthesis coupled electron transport
GWG05_RS12260	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWG05_RS12265	COG1007	ATP synthesis coupled electron transport
GWG05_RS12270	COG0047	phosphoribosylformylglycinamidine synthase activity
GWG05_RS12270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GWG05_RS12275	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GWG05_RS12285	COG1645	bacterial-type flagellum-dependent swarming motility
GWG05_RS12290	COG1160	GTP binding
GWG05_RS12295	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWG05_RS12300	COG2976	Protein conserved in bacteria
GWG05_RS12305	COG0124	histidyl-tRNA synthetase
GWG05_RS12315	COG1426	Protein conserved in bacteria
GWG05_RS12325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GWG05_RS12330	COG0105	UTP biosynthetic process
GWG05_RS12345	COG0633	Ferredoxin
GWG05_RS12350	COG0443	Heat shock 70 kDa protein
GWG05_RS12355	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GWG05_RS12365	COG0822	iron-sulfur transferase activity
GWG05_RS12370	COG1104	cysteine desulfurase activity
GWG05_RS12385	COG3154	lipid carrier protein
GWG05_RS12390	COG0826	peptidase U32
GWG05_RS12395	COG0826	peptidase U32
GWG05_RS12405	COG2897	thiosulfate sulfurtransferase activity
GWG05_RS12410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWG05_RS12415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWG05_RS12420	COG1862	Preprotein translocase
GWG05_RS12425	COG0343	queuine tRNA-ribosyltransferase activity
GWG05_RS12430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GWG05_RS12435	COG0517	IMP dehydrogenase activity
GWG05_RS12440	COG0450	alkyl hydroperoxide reductase
GWG05_RS12445	COG3634	alkyl hydroperoxide reductase activity
GWG05_RS12480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWG05_RS12520	COG5642	Protein of unknown function (DUF2384)
GWG05_RS12545	COG5433	transposase activity
GWG05_RS12560	COG3039	Transposase
GWG05_RS12580	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GWG05_RS12585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GWG05_RS12605	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWG05_RS12605	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWG05_RS12610	COG0509	glycine decarboxylation via glycine cleavage system
GWG05_RS12615	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GWG05_RS12620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWG05_RS12625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWG05_RS12645	COG2814	Major facilitator Superfamily
GWG05_RS12650	COG0444	Belongs to the ABC transporter superfamily
GWG05_RS12655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWG05_RS12660	COG0601	transmembrane transport
GWG05_RS12670	COG0625	glutathione transferase activity
GWG05_RS12675	COG0625	glutathione transferase activity
GWG05_RS12685	COG0483	inositol monophosphate 1-phosphatase activity
GWG05_RS12700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWG05_RS12705	COG2056	Na+-H+ antiporter family
GWG05_RS12710	COG2814	Major facilitator Superfamily
GWG05_RS12715	COG0583	DNA-binding transcription factor activity
GWG05_RS12720	COG5001	Diguanylate cyclase
GWG05_RS12735	COG2050	protein possibly involved in aromatic compounds catabolism
GWG05_RS12745	COG0247	lactate metabolic process
GWG05_RS12745	COG0277	FAD linked oxidase domain protein
GWG05_RS12760	COG1253	flavin adenine dinucleotide binding
GWG05_RS12765	COG1902	pentaerythritol trinitrate reductase activity
GWG05_RS12775	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GWG05_RS12780	COG0647	UMP catabolic process
GWG05_RS12790	COG0367	asparagine synthase
GWG05_RS12805	COG0625	glutathione transferase activity
GWG05_RS12815	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GWG05_RS12830	COG0564	pseudouridine synthase activity
GWG05_RS12835	COG5001	Diguanylate cyclase
GWG05_RS12845	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GWG05_RS12880	COG0670	Belongs to the BI1 family
GWG05_RS12885	COG1289	transmembrane transporter activity
GWG05_RS12890	COG2920	part of a sulfur-relay system
GWG05_RS12895	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GWG05_RS12900	COG0285	dihydrofolate synthase activity
GWG05_RS12905	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GWG05_RS12910	COG0101	tRNA pseudouridine synthase activity
GWG05_RS12920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GWG05_RS12925	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWG05_RS12935	COG1464	Belongs to the NlpA lipoprotein family
GWG05_RS12965	COG1119	ATPase activity
GWG05_RS12970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWG05_RS12970	COG0574	Belongs to the PEP-utilizing enzyme family
GWG05_RS12975	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GWG05_RS12985	COG1113	amino acid transport
GWG05_RS13065	COG1242	4 iron, 4 sulfur cluster binding
GWG05_RS13070	COG0069	glutamate synthase activity
GWG05_RS13070	COG0067	glutamate synthase
GWG05_RS13070	COG0070	glutamate synthase
GWG05_RS13075	COG0493	'glutamate synthase
GWG05_RS13090	COG5433	transposase activity
GWG05_RS13095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG05_RS13120	COG4104	PAAR repeat-containing protein
GWG05_RS13130	COG0513	Belongs to the DEAD box helicase family
GWG05_RS13160	COG3706	GGDEF domain
GWG05_RS13165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWG05_RS13170	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GWG05_RS13175	COG0505	Belongs to the CarA family
GWG05_RS13180	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GWG05_RS13190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GWG05_RS13195	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GWG05_RS13200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWG05_RS13205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GWG05_RS13210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWG05_RS13215	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GWG05_RS13220	COG4139	cobalamin transport
GWG05_RS13245	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GWG05_RS13255	COG0023	Translation Initiation Factor
GWG05_RS13260	COG2119	membrane
GWG05_RS13295	COG2203	Gaf domain
GWG05_RS13295	COG2199	diguanylate cyclase activity
GWG05_RS13335	COG0215	cysteine-tRNA ligase activity
GWG05_RS13340	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GWG05_RS13350	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWG05_RS13355	COG2261	transglycosylase associated protein
GWG05_RS13360	COG1309	transcriptional regulator
GWG05_RS13365	COG0604	alcohol dehydrogenase
GWG05_RS13380	COG0583	DNA-binding transcription factor activity
GWG05_RS13405	COG0322	excinuclease ABC activity
GWG05_RS13410	COG2197	response regulator
GWG05_RS13415	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GWG05_RS13420	COG2835	tetraacyldisaccharide 4'-kinase activity
GWG05_RS13425	COG1663	tetraacyldisaccharide 4'-kinase activity
GWG05_RS13430	COG1132	(ABC) transporter
GWG05_RS13435	COG2333	competence protein COMEC
GWG05_RS13435	COG0658	competence protein
GWG05_RS13450	COG0433	COG0433 Predicted ATPase
GWG05_RS13455	COG1448	Aminotransferase
GWG05_RS13470	COG1199	ATP-dependent helicase activity
GWG05_RS13480	COG0123	including yeast histone deacetylase and acetoin utilization protein
GWG05_RS13485	COG0477	Major facilitator Superfamily
GWG05_RS13490	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GWG05_RS13495	COG1785	Belongs to the alkaline phosphatase family
GWG05_RS13515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWG05_RS13520	COG3706	GGDEF domain
GWG05_RS13525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG05_RS13530	COG0765	amino acid transport
GWG05_RS13535	COG1126	abc transporter atp-binding protein
GWG05_RS13545	COG0531	amino acid
GWG05_RS13560	COG1253	flavin adenine dinucleotide binding
GWG05_RS13565	COG0704	Plays a role in the regulation of phosphate uptake
GWG05_RS13575	COG0581	inorganic phosphate transmembrane transporter activity
GWG05_RS13580	COG0573	inorganic phosphate transmembrane transporter activity
GWG05_RS13585	COG0590	tRNA wobble adenosine to inosine editing
GWG05_RS13600	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GWG05_RS13620	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GWG05_RS13625	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GWG05_RS13630	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GWG05_RS13635	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GWG05_RS13645	COG3852	Histidine kinase
GWG05_RS13660	COG2716	regulation of RNA biosynthetic process
GWG05_RS13665	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GWG05_RS13675	COG2239	Acts as a magnesium transporter
GWG05_RS13690	COG3951	Flagellar rod assembly protein muramidase FlgJ
GWG05_RS13690	COG1705	Flagellar rod assembly protein muramidase FlgJ
GWG05_RS13695	COG1706	bacterial-type flagellum-dependent cell motility
GWG05_RS13700	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GWG05_RS13715	COG1749	Flagellar hook protein flgE
GWG05_RS13730	COG1815	bacterial-type flagellum-dependent cell motility
GWG05_RS13735	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GWG05_RS13740	COG0835	chemotaxis
GWG05_RS13740	COG0784	Response regulator, receiver
GWG05_RS13745	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
GWG05_RS13760	COG0622	Phosphoesterase
GWG05_RS13765	COG4166	transmembrane transport
GWG05_RS13780	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GWG05_RS13790	COG0697	spore germination
GWG05_RS13795	COG4166	transmembrane transport
GWG05_RS13820	COG1278	Cold shock
GWG05_RS13860	COG3132	Protein of unknown function, DUF480
GWG05_RS13875	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWG05_RS13895	COG3206	protein involved in exopolysaccharide biosynthesis
GWG05_RS13895	COG0489	protein tyrosine kinase activity
GWG05_RS13900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWG05_RS13905	COG1596	polysaccharide export
GWG05_RS13915	COG1215	transferase activity, transferring glycosyl groups
GWG05_RS13935	COG1215	transferase activity, transferring glycosyl groups
GWG05_RS13945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GWG05_RS13955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWG05_RS13970	COG2755	lipolytic protein G-D-S-L family
GWG05_RS13970	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GWG05_RS14000	COG1091	dTDP-4-dehydrorhamnose reductase activity
GWG05_RS14010	COG0745	RESPONSE REGULATOR receiver
GWG05_RS14025	COG1737	Transcriptional regulator
GWG05_RS14030	COG0469	pyruvate kinase activity
GWG05_RS14040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWG05_RS14045	COG1960	acyl-CoA dehydrogenase activity
GWG05_RS14055	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GWG05_RS14065	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GWG05_RS14075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWG05_RS14080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG05_RS14085	COG1309	transcriptional regulator
GWG05_RS14100	COG1946	Acyl-CoA thioesterase
GWG05_RS14115	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GWG05_RS14125	COG0009	L-threonylcarbamoyladenylate synthase
GWG05_RS14130	COG0613	PHP domain protein
GWG05_RS14135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GWG05_RS14140	COG0512	Glutamine amidotransferase of anthranilate synthase
GWG05_RS14140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWG05_RS14145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWG05_RS14150	COG0134	indole-3-glycerol-phosphate synthase activity
GWG05_RS14150	COG0135	phosphoribosylanthranilate isomerase activity
GWG05_RS14155	COG0133	tryptophan synthase activity
GWG05_RS14160	COG0159	tryptophan synthase activity
GWG05_RS14230	COG4521	taurine ABC transporter
GWG05_RS14235	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GWG05_RS14240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWG05_RS14245	COG2175	clavaminate synthase activity
GWG05_RS14250	COG5507	3-demethylubiquinone-9 3-methyltransferase
GWG05_RS14255	COG2814	Major facilitator Superfamily
GWG05_RS14260	COG0109	protoheme IX farnesyltransferase activity
GWG05_RS14265	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GWG05_RS14270	COG1845	cytochrome c oxidase, subunit III
GWG05_RS14275	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWG05_RS14280	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWG05_RS14285	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWG05_RS14290	COG0583	DNA-binding transcription factor activity
GWG05_RS14310	COG1846	Transcriptional regulator
GWG05_RS14325	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GWG05_RS14340	COG0745	RESPONSE REGULATOR receiver
GWG05_RS14350	COG0708	Exodeoxyribonuclease III
GWG05_RS14360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG05_RS14365	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWG05_RS14380	COG0095	Lipoate-protein ligase
GWG05_RS14410	COG0640	Transcriptional regulator
GWG05_RS14420	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWG05_RS14430	COG1285	pathogenesis
GWG05_RS14460	COG0484	heat shock protein binding
GWG05_RS14465	COG0443	Heat shock 70 kDa protein
GWG05_RS14470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GWG05_RS14475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GWG05_RS14480	COG3706	GGDEF domain
GWG05_RS14485	COG0497	DNA recombination
GWG05_RS14495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG05_RS14500	COG1136	(ABC) transporter
GWG05_RS14500	COG0577	efflux transmembrane transporter activity
GWG05_RS14510	COG2375	cellular response to nickel ion
GWG05_RS14515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWG05_RS14520	COG2916	Histone family protein nucleoid-structuring protein H-NS
GWG05_RS14525	COG0583	DNA-binding transcription factor activity
GWG05_RS14530	COG3048	D-serine ammonia-lyase activity
GWG05_RS14540	COG0538	isocitrate dehydrogenase activity
GWG05_RS14575	COG0456	acetyltransferase
GWG05_RS14580	COG1187	pseudouridine synthase activity
GWG05_RS14590	COG0482	sulfurtransferase activity
GWG05_RS14595	COG2915	High frequency lysogenization protein hflD homolog
GWG05_RS14600	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GWG05_RS14605	COG2850	peptidyl-arginine hydroxylation
GWG05_RS14615	COG1196	nuclear chromosome segregation
GWG05_RS14615	COG3264	Mechanosensitive ion channel
GWG05_RS14645	COG0281	malic enzyme
GWG05_RS14650	COG0746	molybdenum cofactor guanylyltransferase activity
GWG05_RS14655	COG1763	Mo-molybdopterin cofactor biosynthetic process
GWG05_RS14660	COG1289	transmembrane transporter activity
GWG05_RS14665	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GWG05_RS14695	COG3220	belongs to the UPF0276 family
GWG05_RS14705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWG05_RS14730	COG0454	-acetyltransferase
GWG05_RS14745	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWG05_RS14750	COG0083	homoserine kinase activity
GWG05_RS14760	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GWG05_RS14765	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GWG05_RS14780	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GWG05_RS14790	COG0745	RESPONSE REGULATOR receiver
GWG05_RS14805	COG4988	ABC transporter
GWG05_RS14810	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GWG05_RS14830	COG1720	tRNA m6t6A37 methyltransferase activity
GWG05_RS14845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWG05_RS14850	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GWG05_RS14855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWG05_RS14865	COG2190	(PTS) system
GWG05_RS14870	COG3038	cytochrome b561
GWG05_RS14880	COG0420	3'-5' exonuclease activity
GWG05_RS14885	COG1247	-acetyltransferase
GWG05_RS14890	COG2974	May be involved in recombination
GWG05_RS14900	COG0405	Gamma-glutamyltransferase
GWG05_RS14905	COG4651	solute:proton antiporter activity
GWG05_RS14905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GWG05_RS14940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWG05_RS14945	COG1396	sequence-specific DNA binding
GWG05_RS14945	COG1917	Cupin 2, conserved barrel domain protein
GWG05_RS14950	COG1012	belongs to the aldehyde dehydrogenase family
GWG05_RS14965	COG0531	amino acid
GWG05_RS14970	COG0531	amino acid
GWG05_RS14980	COG1283	sodium-dependent phosphate transmembrane transporter activity
GWG05_RS14990	COG3384	dioxygenase
GWG05_RS14995	COG2205	protein histidine kinase activity
GWG05_RS14995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG05_RS15020	COG2205	protein histidine kinase activity
GWG05_RS15020	COG0784	Response regulator, receiver
GWG05_RS15030	COG1376	ErfK ybiS ycfS ynhG family protein
GWG05_RS15030	COG1388	LysM domain
GWG05_RS15045	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GWG05_RS15050	COG0791	NLP P60 protein
GWG05_RS15065	COG3118	belongs to the thioredoxin family
GWG05_RS15075	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWG05_RS15080	COG0788	formyltetrahydrofolate deformylase activity
GWG05_RS15105	COG1196	nuclear chromosome segregation
GWG05_RS15105	COG0739	heme binding
GWG05_RS15105	COG0741	lytic transglycosylase activity
GWG05_RS15115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GWG05_RS15120	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GWG05_RS15125	COG0673	inositol 2-dehydrogenase activity
GWG05_RS15155	COG1032	radical SAM domain protein
GWG05_RS15160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWG05_RS15170	COG3706	GGDEF domain
GWG05_RS15175	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWG05_RS15180	COG0733	neurotransmitter:sodium symporter activity
GWG05_RS15210	COG0281	malic enzyme
GWG05_RS15215	COG2207	Transcriptional regulator
GWG05_RS15235	COG2233	PERMEase
GWG05_RS15240	COG0095	Lipoate-protein ligase
GWG05_RS15245	COG1115	amino acid carrier protein
GWG05_RS15250	COG0019	diaminopimelate decarboxylase activity
GWG05_RS15260	COG0678	peroxiredoxin activity
GWG05_RS15265	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GWG05_RS15275	COG1126	abc transporter atp-binding protein
GWG05_RS15280	COG0765	amino acid transport
GWG05_RS15285	COG4597	amino acid ABC transporter
GWG05_RS15290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG05_RS15305	COG1131	(ABC) transporter
GWG05_RS15310	COG0545	Peptidyl-prolyl cis-trans isomerase
GWG05_RS15330	COG3142	Participates in the control of copper homeostasis
GWG05_RS15335	COG1940	carbohydrate kinase activity
GWG05_RS15345	COG4783	chaperone-mediated protein folding
GWG05_RS15355	COG5002	protein histidine kinase activity
GWG05_RS15360	COG0745	RESPONSE REGULATOR receiver
GWG05_RS15365	COG0346	lactoylglutathione lyase activity
GWG05_RS15370	COG3706	GGDEF domain
GWG05_RS15375	COG3284	Transcriptional regulator
GWG05_RS15380	COG1012	belongs to the aldehyde dehydrogenase family
GWG05_RS15390	COG0697	spore germination
GWG05_RS15400	COG0667	Aldo Keto reductase
GWG05_RS15415	COG3290	protein histidine kinase activity
GWG05_RS15425	COG1566	PFAM secretion protein HlyD family protein
GWG05_RS15450	COG0602	queuosine metabolic process
GWG05_RS15455	COG1328	CTP reductase activity
GWG05_RS15465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GWG05_RS15470	COG3115	cell septum assembly
GWG05_RS15475	COG1196	nuclear chromosome segregation
GWG05_RS15485	COG2860	membrane
GWG05_RS15495	COG3108	Peptidase M15
GWG05_RS15500	COG2989	Protein conserved in bacteria
GWG05_RS15515	COG0463	Glycosyl transferase, family 2
GWG05_RS15530	COG0366	Alpha amylase catalytic
GWG05_RS15565	COG3706	GGDEF domain
GWG05_RS15570	COG0037	tRNA processing
GWG05_RS15585	COG0488	(ABC) transporter
GWG05_RS15595	COG0531	amino acid
GWG05_RS15600	COG0814	amino acid
GWG05_RS15615	COG0825	malonyl-CoA metabolic process
GWG05_RS15620	COG0587	DNA-directed DNA polymerase activity
GWG05_RS15625	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GWG05_RS15630	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWG05_RS15635	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWG05_RS15640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWG05_RS15645	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWG05_RS15660	COG0750	zinc metalloprotease
GWG05_RS15665	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GWG05_RS15670	COG0575	Belongs to the CDS family
GWG05_RS15675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GWG05_RS15680	COG0233	cytoplasmic translational termination
GWG05_RS15685	COG0528	UMP kinase activity
GWG05_RS15690	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GWG05_RS15695	COG0052	Belongs to the universal ribosomal protein uS2 family
GWG05_RS15700	COG0024	Methionine aminopeptidase
GWG05_RS15705	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GWG05_RS15710	COG2171	N-acyltransferase activity
GWG05_RS15720	COG1263	PTS System
GWG05_RS15720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWG05_RS15745	COG0564	pseudouridine synthase activity
GWG05_RS15750	COG3098	single-species biofilm formation
GWG05_RS15775	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GWG05_RS15785	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GWG05_RS15785	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GWG05_RS15795	COG3706	GGDEF domain
GWG05_RS15800	COG1611	Belongs to the LOG family
GWG05_RS15805	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWG05_RS15810	COG0473	3-isopropylmalate dehydrogenase activity
GWG05_RS15820	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GWG05_RS15835	COG0583	DNA-binding transcription factor activity
GWG05_RS15840	COG0840	transmembrane signaling receptor activity
GWG05_RS15845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWG05_RS15860	COG1477	protein flavinylation
GWG05_RS15865	COG2871	sodium ion transport
GWG05_RS15870	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWG05_RS15875	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWG05_RS15880	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWG05_RS15885	COG1805	sodium ion transport
GWG05_RS15890	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWG05_RS15895	COG0271	Belongs to the BolA IbaG family
GWG05_RS15900	COG2813	Specifically methylates the guanine in position
GWG05_RS15910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GWG05_RS15920	COG2211	Major facilitator Superfamily
GWG05_RS15925	COG3248	Nucleoside-binding outer membrane protein
GWG05_RS15930	COG1666	GTP binding
GWG05_RS15935	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GWG05_RS15945	COG0659	secondary active sulfate transmembrane transporter activity
GWG05_RS15950	COG5002	protein histidine kinase activity
GWG05_RS15955	COG0745	RESPONSE REGULATOR receiver
GWG05_RS15960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG05_RS15965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWG05_RS15980	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWG05_RS15990	COG1151	hydroxylamine reductase activity
GWG05_RS15995	COG0783	Belongs to the Dps family
GWG05_RS16020	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GWG05_RS16035	COG4221	oxidoreductase activity
GWG05_RS16045	COG0415	Belongs to the DNA photolyase family
GWG05_RS16050	COG0789	Transcriptional regulator
GWG05_RS16055	COG3272	Protein of unknown function (DUF1722)
GWG05_RS16080	COG0077	Prephenate dehydratase
GWG05_RS16080	COG1605	Chorismate mutase
GWG05_RS16110	COG2133	pyrroloquinoline quinone binding
GWG05_RS16120	COG1349	DNA-binding transcription factor activity
GWG05_RS16125	COG2084	Dehydrogenase
GWG05_RS16130	COG3395	kinase activity
GWG05_RS16135	COG0235	Class ii aldolase
GWG05_RS16140	COG3622	Belongs to the hyi family
GWG05_RS16145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWG05_RS16150	COG2610	gluconate transmembrane transporter activity
GWG05_RS16160	COG0840	transmembrane signaling receptor activity
GWG05_RS16170	COG0300	oxidoreductase activity
GWG05_RS16195	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GWG05_RS16215	COG3813	Protein conserved in bacteria
GWG05_RS16225	COG0826	peptidase U32
GWG05_RS16230	COG1280	lysine exporter protein (LysE YggA)
GWG05_RS16265	COG2199	diguanylate cyclase activity
GWG05_RS16265	COG2203	Gaf domain
GWG05_RS16265	COG2200	EAL domain
GWG05_RS16310	COG1566	PFAM secretion protein HlyD family protein
GWG05_RS16320	COG0114	fumarate hydratase activity
GWG05_RS16330	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GWG05_RS16330	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GWG05_RS16330	COG0506	proline dehydrogenase activity
GWG05_RS16335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWG05_RS16350	COG0737	Belongs to the 5'-nucleotidase family
GWG05_RS16370	COG2204	response regulator
GWG05_RS16375	COG0545	Peptidyl-prolyl cis-trans isomerase
GWG05_RS16385	COG2900	Belongs to the SlyX family
GWG05_RS16390	COG1047	Peptidyl-prolyl cis-trans
GWG05_RS16395	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GWG05_RS16405	COG0835	chemotaxis
GWG05_RS16405	COG0784	Response regulator, receiver
GWG05_RS16410	COG0429	hydrolase of the alpha beta-hydrolase fold
GWG05_RS16415	COG5001	Diguanylate cyclase
GWG05_RS16415	COG2203	Gaf domain
GWG05_RS16415	COG3706	GGDEF domain
GWG05_RS16415	COG4251	negative regulation of phosphorylation
GWG05_RS16420	COG3089	Belongs to the UPF0270 family
GWG05_RS16425	COG3954	Phosphoribulokinase
GWG05_RS16440	COG1765	OsmC-like protein
GWG05_RS16450	COG2226	methyltransferase
GWG05_RS16460	COG2202	Pas domain
GWG05_RS16460	COG2205	protein histidine kinase activity
GWG05_RS16465	COG2814	Major facilitator Superfamily
GWG05_RS16490	COG0748	coenzyme F420 binding
GWG05_RS16495	COG3721	Heme iron utilization protein
GWG05_RS16505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWG05_RS16530	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GWG05_RS16540	COG0463	Glycosyl transferase, family 2
GWG05_RS16545	COG0741	lytic transglycosylase activity
GWG05_RS16550	COG0488	(ABC) transporter
GWG05_RS16560	COG2252	PERMEase
GWG05_RS16565	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GWG05_RS16570	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GWG05_RS16575	COG3178	'Phosphotransferase
GWG05_RS16580	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GWG05_RS16595	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GWG05_RS16600	COG2967	ApaG domain
GWG05_RS16605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWG05_RS16615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWG05_RS16620	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GWG05_RS16630	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GWG05_RS16635	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GWG05_RS16640	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GWG05_RS16645	COG0142	geranyltranstransferase activity
GWG05_RS16650	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GWG05_RS16655	COG0330	HflC and HflK could
GWG05_RS16660	COG0330	HflC and HflK could
GWG05_RS16665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GWG05_RS16670	COG1923	regulation of RNA biosynthetic process
GWG05_RS16675	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GWG05_RS16680	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWG05_RS16690	COG0802	atpase or kinase
GWG05_RS16695	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GWG05_RS16695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GWG05_RS16715	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWG05_RS16720	COG2011	ABC-type metal ion transport system permease component
GWG05_RS16725	COG1464	Belongs to the NlpA lipoprotein family
GWG05_RS16760	COG5002	protein histidine kinase activity
GWG05_RS16760	COG0784	Response regulator, receiver
GWG05_RS16760	COG2198	Histidine kinase
GWG05_RS16780	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GWG05_RS16795	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GWG05_RS16800	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GWG05_RS16805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWG05_RS16810	COG2716	regulation of RNA biosynthetic process
GWG05_RS16815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWG05_RS16820	COG3013	Belongs to the UPF0304 family
GWG05_RS16830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GWG05_RS16835	COG0280	phosphate acetyltransferase
GWG05_RS16835	COG0857	belongs to the CobB CobQ family
GWG05_RS16840	COG0440	acetolactate synthase activity
GWG05_RS16845	COG0028	Belongs to the TPP enzyme family
GWG05_RS16860	COG0671	phosphoesterase, PA-phosphatase related
GWG05_RS16870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWG05_RS16875	COG0473	3-isopropylmalate dehydrogenase activity
GWG05_RS16880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GWG05_RS16885	COG0066	3-isopropylmalate dehydratase activity
GWG05_RS16900	COG4143	(ABC) transporter
GWG05_RS16905	COG1178	ABC-type Fe3 transport system permease component
GWG05_RS16910	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GWG05_RS16920	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GWG05_RS16930	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWG05_RS16960	COG0316	Belongs to the HesB IscA family
GWG05_RS16970	COG0038	chloride channel
GWG05_RS16975	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWG05_RS16990	COG0671	phosphoesterase, PA-phosphatase related
GWG05_RS17000	COG0583	DNA-binding transcription factor activity
GWG05_RS17005	COG2076	Multidrug Resistance protein
GWG05_RS17015	COG0346	lactoylglutathione lyase activity
GWG05_RS17020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWG05_RS17025	COG1643	Atp-dependent helicase
GWG05_RS17035	COG1489	DNA binding
GWG05_RS17040	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GWG05_RS17045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWG05_RS17055	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GWG05_RS17060	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GWG05_RS17065	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GWG05_RS17075	COG0842	Transport permease protein
GWG05_RS17080	COG1131	(ABC) transporter
GWG05_RS17095	COG0163	prenyltransferase activity
GWG05_RS17100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWG05_RS17105	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GWG05_RS17120	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GWG05_RS17135	COG1136	(ABC) transporter
GWG05_RS17185	COG0529	Catalyzes the synthesis of activated sulfate
GWG05_RS17190	COG0471	metal ion transport
GWG05_RS17190	COG3273	potassium ion transport
GWG05_RS17195	COG2895	sulfate adenylyltransferase (ATP) activity
GWG05_RS17200	COG0175	sulfate reduction
GWG05_RS17205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWG05_RS17205	COG1648	precorrin-2 dehydrogenase activity
GWG05_RS17210	COG0330	HflC and HflK could
GWG05_RS17215	COG1585	Membrane protein implicated in regulation of membrane protease activity
GWG05_RS17225	COG0673	inositol 2-dehydrogenase activity
GWG05_RS17235	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GWG05_RS17240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWG05_RS17245	COG3036	rescue of stalled ribosome
GWG05_RS17260	COG0138	bifunctional purine biosynthesis protein purh
GWG05_RS17310	COG3039	Transposase
GWG05_RS17340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GWG05_RS17345	COG0358	DNA primase activity
GWG05_RS17350	COG1610	YqeY-like protein
GWG05_RS17355	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GWG05_RS17360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GWG05_RS17370	COG4942	peptidase
GWG05_RS17370	COG1388	LysM domain
GWG05_RS17375	COG1238	metal cluster binding
GWG05_RS17380	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GWG05_RS17385	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GWG05_RS17390	COG0585	pseudouridine synthase activity
GWG05_RS17395	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GWG05_RS17400	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GWG05_RS17405	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GWG05_RS17410	COG0148	phosphopyruvate hydratase activity
GWG05_RS17415	COG0504	CTP synthase activity
GWG05_RS17420	COG3956	TIGRFAM MazG family protein
GWG05_RS17425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWG05_RS17430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWG05_RS17440	COG4807	Protein conserved in bacteria
GWG05_RS17445	COG3023	N-Acetylmuramoyl-L-alanine amidase
GWG05_RS17450	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GWG05_RS17455	COG1381	Involved in DNA repair and RecF pathway recombination
GWG05_RS17465	COG0571	ribonuclease III activity
GWG05_RS17470	COG0681	Belongs to the peptidase S26 family
GWG05_RS17475	COG0481	GTPase activity
GWG05_RS17490	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GWG05_RS17495	COG1595	DNA-templated transcription, initiation
GWG05_RS17500	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GWG05_RS17510	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GWG05_RS17520	COG0583	DNA-binding transcription factor activity
GWG05_RS17550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWG05_RS17560	COG0126	phosphoglycerate kinase activity
GWG05_RS17565	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWG05_RS17570	COG1940	carbohydrate kinase activity
GWG05_RS17575	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GWG05_RS17580	COG2816	NAD+ diphosphatase activity
GWG05_RS17585	COG4991	sh3 domain protein
GWG05_RS17590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWG05_RS17605	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GWG05_RS17610	COG1028	Short-chain dehydrogenase reductase Sdr
GWG05_RS17620	COG1505	serine-type exopeptidase activity
GWG05_RS17625	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWG05_RS17630	COG0765	amino acid transport
GWG05_RS17635	COG0765	amino acid transport
GWG05_RS17640	COG1126	abc transporter atp-binding protein
GWG05_RS17645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG05_RS17650	COG3174	membrane
GWG05_RS17655	COG0110	maltose O-acetyltransferase activity
GWG05_RS17685	COG1942	4-Oxalocrotonate Tautomerase
GWG05_RS17695	COG0583	DNA-binding transcription factor activity
GWG05_RS17700	COG0165	Argininosuccinate lyase
GWG05_RS17705	COG0137	argininosuccinate synthase activity
GWG05_RS17715	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWG05_RS17720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GWG05_RS17730	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GWG05_RS17735	COG3447	MASE1 domain protein
GWG05_RS17735	COG5001	Diguanylate cyclase
GWG05_RS17735	COG5002	protein histidine kinase activity
GWG05_RS17740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GWG05_RS17780	COG0583	DNA-binding transcription factor activity
GWG05_RS17785	COG1380	Effector of murein hydrolase LrgA
GWG05_RS17790	COG1346	cytolysis
GWG05_RS17795	COG0460	homoserine dehydrogenase
GWG05_RS17795	COG0527	aspartate kinase activity
GWG05_RS17800	COG0626	cystathionine gamma-synthase activity
GWG05_RS17815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWG05_RS17820	COG0814	amino acid
GWG05_RS17825	COG1218	3'(2'),5'-bisphosphate nucleotidase
GWG05_RS17830	COG0494	nUDIX hydrolase
GWG05_RS17835	COG1011	Hydrolase
GWG05_RS17850	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWG05_RS17865	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GWG05_RS17875	COG3156	type II secretion system protein K
GWG05_RS17880	COG4795	General secretion pathway protein
GWG05_RS17885	COG2165	general secretion pathway protein
GWG05_RS17895	COG2165	general secretion pathway protein
GWG05_RS17900	COG1459	type II secretion system
GWG05_RS17905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWG05_RS17915	COG3031	protein transport across the cell outer membrane
GWG05_RS17925	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GWG05_RS17930	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GWG05_RS17950	COG3133	Outer membrane lipoprotein
GWG05_RS17955	COG3025	triphosphatase activity
GWG05_RS17960	COG1392	Phosphate transport regulator
GWG05_RS17965	COG0306	phosphate transporter
GWG05_RS17970	COG0617	tRNA 3'-terminal CCA addition
GWG05_RS17975	COG3267	Type II secretory pathway component ExeA
GWG05_RS17975	COG3409	Peptidoglycan-binding domain 1 protein
GWG05_RS17985	COG1194	a g-specific adenine glycosylase
GWG05_RS17990	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GWG05_RS18005	COG3240	lipase activity
GWG05_RS18015	COG3009	Protein conserved in bacteria
GWG05_RS18020	COG3008	intermembrane lipid transfer
GWG05_RS18020	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GWG05_RS18025	COG2995	paraquat-inducible protein a
GWG05_RS18035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWG05_RS18040	COG2203	Gaf domain
GWG05_RS18040	COG3706	GGDEF domain
GWG05_RS18040	COG4251	negative regulation of phosphorylation
GWG05_RS18040	COG5001	Diguanylate cyclase
GWG05_RS18045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWG05_RS18050	COG2813	Specifically methylates the guanine in position
GWG05_RS18055	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GWG05_RS18060	COG0297	glycogen (starch) synthase activity
GWG05_RS18100	COG1757	Na H antiporter
GWG05_RS18115	COG3842	ATPase activity
GWG05_RS18120	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWG05_RS18125	COG1177	transmembrane transport
GWG05_RS18130	COG1012	belongs to the aldehyde dehydrogenase family
GWG05_RS18135	COG0109	protoheme IX farnesyltransferase activity
GWG05_RS18165	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GWG05_RS18175	COG1565	acr, cog1565
GWG05_RS18175	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWG05_RS18180	COG1444	tRNA N-acetyltransferase activity
GWG05_RS18200	COG1803	Methylglyoxal synthase
GWG05_RS18215	COG0252	asparaginase activity
GWG05_RS18235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWG05_RS18235	COG1263	PTS System
GWG05_RS18240	COG0366	Alpha amylase catalytic
GWG05_RS18245	COG0110	maltose O-acetyltransferase activity
GWG05_RS18250	COG1522	sequence-specific DNA binding
GWG05_RS18280	COG3068	Protein conserved in bacteria
GWG05_RS18290	COG0739	heme binding
GWG05_RS18310	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GWG05_RS18315	COG1121	(ABC) transporter
GWG05_RS18320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWG05_RS18325	COG0583	DNA-binding transcription factor activity
GWG05_RS18335	COG1573	uracil-dna glycosylase
GWG05_RS18340	COG2962	Rard protein
GWG05_RS18345	COG2827	Endonuclease containing a URI domain
GWG05_RS18360	COG1842	Phage shock protein A
GWG05_RS18365	COG0204	Acyl-transferase
GWG05_RS18385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWG05_RS18395	COG0484	heat shock protein binding
GWG05_RS18445	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GWG05_RS18480	COG1289	transmembrane transporter activity
GWG05_RS18485	COG1566	PFAM secretion protein HlyD family protein
GWG05_RS18500	COG1051	belongs to the nudix hydrolase family
GWG05_RS18505	COG3150	esterase
GWG05_RS18515	COG3151	Protein conserved in bacteria
GWG05_RS18520	COG0494	nUDIX hydrolase
GWG05_RS18525	COG1538	Outer membrane efflux protein
GWG05_RS18530	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GWG05_RS18530	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GWG05_RS18535	COG1560	Kdo2-lipid A biosynthetic process
GWG05_RS18550	COG2771	luxR family
GWG05_RS18555	COG3916	Acyl-homoserine-lactone synthase
GWG05_RS18565	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GWG05_RS18570	COG2213	PTS system mannitol-specific
GWG05_RS18570	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWG05_RS18575	COG0246	Mannitol dehydrogenase
GWG05_RS18580	COG3722	fumarate hydratase activity
GWG05_RS18585	COG3263	regulation of cellular component size
GWG05_RS18605	COG1671	Belongs to the UPF0178 family
GWG05_RS18625	COG5433	transposase activity
GWG05_RS18645	COG0513	Belongs to the DEAD box helicase family
GWG05_RS18665	COG1575	Belongs to the MenA family. Type 1 subfamily
GWG05_RS18670	COG1169	isochorismate synthase
GWG05_RS18675	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GWG05_RS18680	COG0596	Alpha beta hydrolase
GWG05_RS18685	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GWG05_RS18695	COG0318	PFAM AMP-dependent synthetase and ligase
GWG05_RS18700	COG3291	Pkd domain containing protein
GWG05_RS18705	COG2949	membrane
GWG05_RS18710	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GWG05_RS18720	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GWG05_RS18750	COG2873	o-acetylhomoserine
GWG05_RS18760	COG1979	alcohol dehydrogenase
GWG05_RS18775	COG4221	oxidoreductase activity
GWG05_RS18795	COG1285	pathogenesis
GWG05_RS18810	COG1368	sulfuric ester hydrolase activity
GWG05_RS18815	COG1522	sequence-specific DNA binding
GWG05_RS18825	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GWG05_RS18835	COG1058	Belongs to the CinA family
GWG05_RS18835	COG1546	Belongs to the CinA family
GWG05_RS18840	COG1988	membrane-bound metal-dependent
GWG05_RS18855	COG0561	phosphatase activity
GWG05_RS18860	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GWG05_RS18870	COG1011	Hydrolase
GWG05_RS18885	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GWG05_RS18890	COG0019	diaminopimelate decarboxylase activity
GWG05_RS18900	COG1965	Belongs to the frataxin family
GWG05_RS18905	COG0400	carboxylic ester hydrolase activity
GWG05_RS18910	COG3072	Adenylate cyclase
GWG05_RS18915	COG0181	hydroxymethylbilane synthase activity
GWG05_RS18925	COG2959	enzyme of heme biosynthesis
GWG05_RS18930	COG3071	HemY protein
GWG05_RS18935	COG0312	modulator of DNA gyrase
GWG05_RS18940	COG3028	Belongs to the UPF0307 family
GWG05_RS18950	COG2926	Belongs to the UPF0265 family
GWG05_RS18985	COG1396	sequence-specific DNA binding
GWG05_RS18990	COG3135	benzoate transporter
GWG05_RS19020	COG3047	cAMP biosynthetic process
GWG05_RS19025	COG5433	transposase activity
GWG05_RS19030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWG05_RS19035	COG2197	response regulator
GWG05_RS19055	COG1278	Cold shock
GWG05_RS19060	COG2205	protein histidine kinase activity
GWG05_RS19065	COG0745	RESPONSE REGULATOR receiver
GWG05_RS19085	COG3706	GGDEF domain
GWG05_RS19090	COG0347	Belongs to the P(II) protein family
GWG05_RS19095	COG0004	ammonium transporteR
GWG05_RS19105	COG0346	lactoylglutathione lyase activity
GWG05_RS19120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWG05_RS19125	COG1074	ATP-dependent DNA helicase activity
GWG05_RS19130	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GWG05_RS19135	COG2259	Doxx family
GWG05_RS19140	COG1741	Belongs to the pirin family
GWG05_RS19150	COG0583	DNA-binding transcription factor activity
GWG05_RS19175	COG1175	transmembrane transport
GWG05_RS19185	COG3842	ATPase activity
GWG05_RS19215	COG0456	acetyltransferase
GWG05_RS19220	COG0753	catalase activity
GWG05_RS19240	COG0494	nUDIX hydrolase
GWG05_RS19245	COG0628	permease
GWG05_RS19255	COG2957	Belongs to the agmatine deiminase family
GWG05_RS19270	COG2957	Belongs to the agmatine deiminase family
GWG05_RS19275	COG0583	DNA-binding transcription factor activity
GWG05_RS19290	COG1461	Dihydroxyacetone kinase
GWG05_RS19295	COG2376	Dihydroxyacetone kinase
GWG05_RS19300	COG2252	PERMEase
GWG05_RS19305	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GWG05_RS19340	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GWG05_RS19345	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWG05_RS19350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWG05_RS19355	COG0049	tRNA binding
GWG05_RS19360	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GWG05_RS19365	COG2168	tRNA wobble position uridine thiolation
GWG05_RS19375	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GWG05_RS19380	COG0251	oxidation-reduction process
GWG05_RS19385	COG2964	Protein conserved in bacteria
GWG05_RS19390	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GWG05_RS19395	COG0085	RNA polymerase activity
GWG05_RS19400	COG0222	ribosome binding
GWG05_RS19405	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GWG05_RS19410	COG0081	regulation of translation
GWG05_RS19415	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GWG05_RS19420	COG0250	Participates in transcription elongation, termination and antitermination
GWG05_RS19435	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWG05_RS19460	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GWG05_RS19465	COG0569	domain protein
GWG05_RS19470	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWG05_RS19475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GWG05_RS19480	COG3005	denitrification pathway
GWG05_RS19485	COG0243	molybdopterin cofactor binding
GWG05_RS19500	COG0745	RESPONSE REGULATOR receiver
GWG05_RS19520	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GWG05_RS19530	COG2204	response regulator
GWG05_RS19540	COG2205	protein histidine kinase activity
GWG05_RS19560	COG0517	IMP dehydrogenase activity
GWG05_RS19560	COG0516	GMP reductase activity
GWG05_RS19570	COG1522	sequence-specific DNA binding
GWG05_RS19575	COG2502	aspartate--ammonia ligase
GWG05_RS19590	COG0583	DNA-binding transcription factor activity
GWG05_RS19595	COG0542	response to heat
GWG05_RS19605	COG0564	pseudouridine synthase activity
GWG05_RS19610	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWG05_RS19615	COG3681	Belongs to the UPF0597 family
GWG05_RS19625	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GWG05_RS19630	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GWG05_RS19635	COG1979	alcohol dehydrogenase
GWG05_RS19640	COG2207	Transcriptional regulator
GWG05_RS19645	COG3040	lipid binding
GWG05_RS19655	COG0840	transmembrane signaling receptor activity
GWG05_RS19665	COG0583	DNA-binding transcription factor activity
GWG05_RS19685	COG0540	Belongs to the ATCase OTCase family
GWG05_RS19690	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GWG05_RS19695	COG1438	arginine binding
GWG05_RS19700	COG1288	antiporter activity
GWG05_RS19705	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWG05_RS19745	COG3250	beta-galactosidase activity
GWG05_RS19750	COG1609	Transcriptional regulator
GWG05_RS19755	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWG05_RS19765	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWG05_RS19770	COG2017	converts alpha-aldose to the beta-anomer
GWG05_RS19775	COG0667	Aldo Keto reductase
GWG05_RS19780	COG1968	undecaprenyl-diphosphatase activity
GWG05_RS19785	COG3806	Anti-sigma factor
GWG05_RS19790	COG1595	DNA-templated transcription, initiation
GWG05_RS19810	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GWG05_RS19815	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GWG05_RS19820	COG0477	Major facilitator Superfamily
GWG05_RS19825	COG0583	DNA-binding transcription factor activity
GWG05_RS19835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG05_RS19840	COG1131	(ABC) transporter
GWG05_RS19845	COG0842	Transport permease protein
GWG05_RS19850	COG0842	Transport permease protein
GWG05_RS19855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWG05_RS19865	COG2116	formate transmembrane transporter activity
GWG05_RS19870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWG05_RS19870	COG1648	precorrin-2 dehydrogenase activity
GWG05_RS19875	COG2239	Acts as a magnesium transporter
GWG05_RS19880	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GWG05_RS19885	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GWG05_RS19895	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GWG05_RS19905	COG0514	ATP-dependent DNA helicase (RecQ)
GWG05_RS19910	COG2050	protein possibly involved in aromatic compounds catabolism
GWG05_RS19925	COG2258	MOSC domain
GWG05_RS19930	COG1177	transmembrane transport
GWG05_RS19935	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWG05_RS19940	COG3842	ATPase activity
GWG05_RS19960	COG0174	glutamine synthetase
GWG05_RS19980	COG3045	CreA protein
GWG05_RS19985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWG05_RS19990	COG0443	Heat shock 70 kDa protein
GWG05_RS20005	COG0366	Alpha amylase catalytic
GWG05_RS20020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWG05_RS20025	COG0745	RESPONSE REGULATOR receiver
GWG05_RS20035	COG2205	protein histidine kinase activity
GWG05_RS20045	COG0281	malic enzyme
GWG05_RS20050	COG0702	epimerase
GWG05_RS20055	COG0254	rRNA binding
GWG05_RS20060	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GWG05_RS20065	COG3039	Transposase
GWG05_RS20080	COG0129	dihydroxy-acid dehydratase activity
GWG05_RS20090	COG3978	acetolactate synthase activity
GWG05_RS20100	COG0606	chelatase, subunit chli
GWG05_RS20105	COG0204	Acyl-transferase
GWG05_RS20110	COG0204	Acyl-transferase
GWG05_RS20115	COG1683	Conserved Protein
GWG05_RS20125	COG1335	isochorismatase
GWG05_RS20135	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GWG05_RS20140	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GWG05_RS20150	COG3084	Protein conserved in bacteria
GWG05_RS20155	COG4251	negative regulation of phosphorylation
GWG05_RS20155	COG3706	GGDEF domain
GWG05_RS20155	COG2203	Gaf domain
GWG05_RS20155	COG5001	Diguanylate cyclase
GWG05_RS20170	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GWG05_RS20175	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GWG05_RS20180	COG1561	YicC-like family, N-terminal region
GWG05_RS20190	COG1519	Transferase
GWG05_RS20195	COG0859	PFAM glycosyl transferase family 9
GWG05_RS20200	COG0463	Glycosyl transferase, family 2
GWG05_RS20205	COG0859	PFAM glycosyl transferase family 9
GWG05_RS20210	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GWG05_RS20215	COG2990	Protein conserved in bacteria
GWG05_RS20220	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GWG05_RS20230	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GWG05_RS20235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GWG05_RS20240	COG2003	Belongs to the UPF0758 family
GWG05_RS20245	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GWG05_RS20250	COG0756	dUTP diphosphatase activity
GWG05_RS20255	COG1309	transcriptional regulator
GWG05_RS20265	COG0668	transmembrane transport
GWG05_RS20275	COG0166	Belongs to the GPI family
GWG05_RS20280	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GWG05_RS20285	COG0583	DNA-binding transcription factor activity
GWG05_RS20295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWG05_RS20295	COG1042	CoA-binding domain protein
GWG05_RS20295	COG0045	succinate-CoA ligase (ADP-forming) activity
GWG05_RS20320	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GWG05_RS20325	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWG05_RS20330	COG1739	Uncharacterized protein family UPF0029
GWG05_RS20335	COG0006	proline dipeptidase activity
GWG05_RS20340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWG05_RS20345	COG1024	Enoyl-CoA hydratase
GWG05_RS20345	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWG05_RS20350	COG0183	Belongs to the thiolase family
GWG05_RS20355	COG0745	RESPONSE REGULATOR receiver
GWG05_RS20390	COG0425	Belongs to the sulfur carrier protein TusA family
GWG05_RS20395	COG0251	oxidation-reduction process
GWG05_RS20415	COG2885	chlorophyll binding
GWG05_RS20425	COG1335	isochorismatase
GWG05_RS20430	COG2818	Glycosylase
GWG05_RS20435	COG0752	glycyl-tRNA synthetase alpha subunit
GWG05_RS20440	COG0751	glycine-tRNA ligase activity
GWG05_RS20455	COG5001	Diguanylate cyclase
GWG05_RS20455	COG4251	negative regulation of phosphorylation
GWG05_RS20455	COG3706	GGDEF domain
GWG05_RS20455	COG2203	Gaf domain
GWG05_RS20480	COG0814	amino acid
GWG05_RS20485	COG0814	amino acid
GWG05_RS20490	COG3033	Beta-eliminating lyase
GWG05_RS20500	COG0348	domain, Protein
GWG05_RS20510	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWG05_RS20515	COG1773	rubredoxin
GWG05_RS20515	COG0426	domain, Protein
GWG05_RS20520	COG3604	Transcriptional regulator
GWG05_RS20525	COG1609	Transcriptional regulator
GWG05_RS20565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWG05_RS20580	COG2960	long-chain fatty acid transporting porin activity
GWG05_RS20590	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GWG05_RS20605	COG3118	belongs to the thioredoxin family
GWG05_RS20610	COG0513	Belongs to the DEAD box helicase family
GWG05_RS20615	COG0248	Ppx GppA phosphatase
GWG05_RS20625	COG0742	ribosomal rna small subunit methyltransferase
GWG05_RS20645	COG0084	hydrolase, TatD family'
GWG05_RS20650	COG0805	protein transport
GWG05_RS20655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWG05_RS20660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWG05_RS20665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GWG05_RS20670	COG3165	ubiquinone biosynthetic process from chorismate
GWG05_RS20680	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GWG05_RS20685	COG0402	S-adenosylhomocysteine deaminase activity
GWG05_RS20725	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GWG05_RS20730	COG0848	biopolymer transport protein
GWG05_RS20735	COG0811	peptide transport
GWG05_RS20740	COG0811	peptide transport
GWG05_RS20750	COG2771	luxR family
GWG05_RS20765	COG1349	DNA-binding transcription factor activity
GWG05_RS20775	COG1028	Short-chain dehydrogenase reductase Sdr
GWG05_RS20810	COG0166	Belongs to the GPI family
GWG05_RS20815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWG05_RS20885	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GWG05_RS20890	COG1349	DNA-binding transcription factor activity
GWG05_RS20895	COG0745	RESPONSE REGULATOR receiver
GWG05_RS20900	COG2205	protein histidine kinase activity
GWG05_RS20910	COG4452	Inner membrane protein CreD
GWG05_RS20915	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GWG05_RS20920	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GWG05_RS20925	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GWG05_RS20930	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GWG05_RS20935	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GWG05_RS20940	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GWG05_RS20945	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GWG05_RS20955	COG0356	it plays a direct role in the translocation of protons across the membrane
GWG05_RS20965	COG1475	DNA binding
GWG05_RS20970	COG1192	Involved in chromosome partitioning
GWG05_RS20975	COG0357	Ribosomal RNA small subunit methyltransferase G
GWG05_RS20980	COG0445	tRNA wobble uridine modification
GWG05_RS20985	COG0716	FMN binding
GWG05_RS20990	COG4774	siderophore transport
GWG05_RS20995	COG4615	Cyclic peptide transporter
GWG05_RS21000	COG1120	ATPase activity
GWG05_RS21005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWG05_RS21015	COG3550	peptidyl-serine autophosphorylation
GWG05_RS21040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GWG05_RS21045	COG0706	membrane insertase activity
GWG05_RS21050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GWG05_RS21055	COG0594	ribonuclease P activity
GWG05_RS21060	COG0230	Belongs to the bacterial ribosomal protein bL34 family