locus-tag	class	description
GWG10_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GWG10_RS00010	COG0592	DNA-directed DNA polymerase activity
GWG10_RS00020	COG0187	DNA topoisomerase II activity
GWG10_RS00030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GWG10_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
GWG10_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
GWG10_RS00045	COG3977	Valine--pyruvate aminotransferase
GWG10_RS00060	COG2814	Major facilitator Superfamily
GWG10_RS00065	COG0745	RESPONSE REGULATOR receiver
GWG10_RS00070	COG2205	protein histidine kinase activity
GWG10_RS00090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWG10_RS00095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG10_RS00095	COG4191	Histidine kinase
GWG10_RS00100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWG10_RS00105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG10_RS00110	COG1309	transcriptional regulator
GWG10_RS00140	COG0561	phosphatase activity
GWG10_RS00145	COG2267	carboxylic ester hydrolase activity
GWG10_RS00150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWG10_RS00155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWG10_RS00160	COG1758	RNA polymerase activity
GWG10_RS00170	COG0859	PFAM glycosyl transferase family 9
GWG10_RS00175	COG3642	lipopolysaccharide core region biosynthetic process
GWG10_RS00215	COG0589	response to stress
GWG10_RS00220	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GWG10_RS00225	COG3706	GGDEF domain
GWG10_RS00230	COG1528	Iron-storage protein
GWG10_RS00235	COG2081	HI0933 family
GWG10_RS00240	COG2223	nitrite transmembrane transporter activity
GWG10_RS00245	COG1280	lysine exporter protein (LysE YggA)
GWG10_RS00260	COG3188	usher protein
GWG10_RS00280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG10_RS00280	COG2205	protein histidine kinase activity
GWG10_RS00290	COG3275	phosphorelay sensor kinase activity
GWG10_RS00295	COG3279	Response regulator of the LytR AlgR family
GWG10_RS00300	COG2223	nitrite transmembrane transporter activity
GWG10_RS00305	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GWG10_RS00310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GWG10_RS00360	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GWG10_RS00365	COG2166	iron-sulfur cluster assembly
GWG10_RS00370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GWG10_RS00390	COG1063	alcohol dehydrogenase
GWG10_RS00405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWG10_RS00450	COG1609	Transcriptional regulator
GWG10_RS00465	COG1580	Controls the rotational direction of flagella during chemotaxis
GWG10_RS00470	COG3161	chorismate lyase activity
GWG10_RS00475	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GWG10_RS00480	COG2937	Belongs to the GPAT DAPAT family
GWG10_RS00485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWG10_RS00500	COG0534	Mate efflux family protein
GWG10_RS00505	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GWG10_RS00510	COG2205	protein histidine kinase activity
GWG10_RS00515	COG0745	RESPONSE REGULATOR receiver
GWG10_RS00525	COG1045	serine acetyltransferase
GWG10_RS00535	COG3074	FtsZ-dependent cytokinesis
GWG10_RS00540	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GWG10_RS00545	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWG10_RS00545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWG10_RS00550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GWG10_RS00585	COG1609	Transcriptional regulator
GWG10_RS00590	COG3250	beta-galactosidase activity
GWG10_RS00595	COG2731	YhcH YjgK YiaL family protein
GWG10_RS00600	COG0531	amino acid
GWG10_RS00605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWG10_RS00610	COG0531	amino acid
GWG10_RS00615	COG0385	Bile acid
GWG10_RS00620	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWG10_RS00645	COG0583	DNA-binding transcription factor activity
GWG10_RS00670	COG0210	DNA helicase
GWG10_RS00715	COG0583	DNA-binding transcription factor activity
GWG10_RS00760	COG1280	lysine exporter protein (LysE YggA)
GWG10_RS00770	COG2962	Rard protein
GWG10_RS00780	COG1012	belongs to the aldehyde dehydrogenase family
GWG10_RS00785	COG1396	sequence-specific DNA binding
GWG10_RS00800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWG10_RS00800	COG0519	Catalyzes the synthesis of GMP from XMP
GWG10_RS00810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWG10_RS00830	COG1322	Protein conserved in bacteria
GWG10_RS00835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWG10_RS00840	COG0569	domain protein
GWG10_RS00845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWG10_RS00845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWG10_RS00850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GWG10_RS00855	COG0242	peptide deformylase activity
GWG10_RS00865	COG0758	DNA mediated transformation
GWG10_RS00870	COG2922	Belongs to the Smg family
GWG10_RS00875	COG0551	DNA topoisomerase type I activity
GWG10_RS00880	COG0009	L-threonylcarbamoyladenylate synthase
GWG10_RS00885	COG0408	coproporphyrinogen oxidase activity
GWG10_RS00890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GWG10_RS00895	COG2801	Transposase and inactivated derivatives
GWG10_RS00900	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GWG10_RS00925	COG3078	GTPase activator activity
GWG10_RS00935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWG10_RS00940	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GWG10_RS00950	COG3852	Histidine kinase
GWG10_RS00960	COG0174	glutamine synthetase
GWG10_RS00970	COG1295	ribonuclease BN
GWG10_RS00975	COG1490	D-aminoacyl-tRNA deacylase activity
GWG10_RS00985	COG0456	acetyltransferase
GWG10_RS00995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWG10_RS01000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWG10_RS01005	COG2610	gluconate transmembrane transporter activity
GWG10_RS01010	COG3265	gluconokinase activity
GWG10_RS01015	COG0129	dihydroxy-acid dehydratase activity
GWG10_RS01020	COG0800	Aldolase
GWG10_RS01035	COG1609	Transcriptional regulator
GWG10_RS01045	COG4942	peptidase
GWG10_RS01050	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GWG10_RS01055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWG10_RS01060	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GWG10_RS01065	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GWG10_RS01070	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GWG10_RS01070	COG0316	Belongs to the HesB IscA family
GWG10_RS01075	COG1040	competence protein
GWG10_RS01080	COG0596	Alpha beta hydrolase
GWG10_RS01095	COG2183	response to ionizing radiation
GWG10_RS01100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWG10_RS01105	COG0745	RESPONSE REGULATOR receiver
GWG10_RS01110	COG2205	protein histidine kinase activity
GWG10_RS01120	COG0051	transcription antitermination factor activity, RNA binding
GWG10_RS01125	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GWG10_RS01130	COG0088	Forms part of the polypeptide exit tunnel
GWG10_RS01135	COG0089	rRNA binding
GWG10_RS01140	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GWG10_RS01145	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GWG10_RS01150	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GWG10_RS01155	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GWG10_RS01160	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GWG10_RS01165	COG0255	Belongs to the universal ribosomal protein uL29 family
GWG10_RS01170	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GWG10_RS01175	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GWG10_RS01180	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GWG10_RS01185	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GWG10_RS01190	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GWG10_RS01195	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GWG10_RS01200	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GWG10_RS01205	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GWG10_RS01210	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GWG10_RS01215	COG1841	ribosomal large subunit assembly
GWG10_RS01220	COG0200	Binds to the 23S rRNA
GWG10_RS01225	COG0201	protein transport
GWG10_RS01230	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWG10_RS01235	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GWG10_RS01240	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GWG10_RS01245	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GWG10_RS01250	COG0202	RNA polymerase activity
GWG10_RS01255	COG0203	ribosomal protein L17
GWG10_RS01265	COG3328	transposase activity
GWG10_RS01320	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWG10_RS01325	COG0583	DNA-binding transcription factor activity
GWG10_RS01330	COG4221	oxidoreductase activity
GWG10_RS01345	COG1770	oligopeptidase
GWG10_RS01350	COG2358	TRAP transporter, solute receptor (TAXI family
GWG10_RS01365	COG3714	YhhN family
GWG10_RS01380	COG0583	DNA-binding transcription factor activity
GWG10_RS01390	COG1301	dicarboxylic acid transport
GWG10_RS01400	COG2095	MarC family integral membrane protein
GWG10_RS01410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWG10_RS01420	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GWG10_RS01430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWG10_RS01455	COG0742	ribosomal rna small subunit methyltransferase
GWG10_RS01460	COG0552	protein localization to endoplasmic reticulum
GWG10_RS01465	COG2884	Cell division ATP-binding protein ftsE
GWG10_RS01470	COG2177	Part of the ABC transporter FtsEX involved in
GWG10_RS01480	COG0288	reversible hydration of carbon dioxide
GWG10_RS01485	COG2188	Transcriptional regulator
GWG10_RS01490	COG1228	amidohydrolase
GWG10_RS01495	COG0010	Belongs to the arginase family
GWG10_RS01500	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GWG10_RS01505	COG2986	histidine ammonia-lyase
GWG10_RS01510	COG3385	transposase activity
GWG10_RS01515	COG0387	Pfam Sodium calcium exchanger
GWG10_RS01520	COG2200	EAL domain
GWG10_RS01535	COG3385	transposase activity
GWG10_RS01590	COG1459	type II secretion system
GWG10_RS01635	COG1077	Cell shape determining protein MreB Mrl
GWG10_RS01640	COG1792	Involved in formation and maintenance of cell shape
GWG10_RS01645	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GWG10_RS01650	COG0424	maF-like protein
GWG10_RS01655	COG1530	ribonuclease E activity
GWG10_RS01660	COG3164	Protein of unknown function
GWG10_RS01665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWG10_RS01670	COG0312	modulator of DNA gyrase
GWG10_RS01685	COG0477	Major facilitator Superfamily
GWG10_RS01695	COG2321	neutral zinc metallopeptidase
GWG10_RS01730	COG0189	ligase activity
GWG10_RS01735	COG0642	Histidine kinase
GWG10_RS01740	COG0745	RESPONSE REGULATOR receiver
GWG10_RS01755	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GWG10_RS01760	COG0352	thiamine-phosphate diphosphorylase activity
GWG10_RS01765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWG10_RS01775	COG2022	thiamine diphosphate biosynthetic process
GWG10_RS01780	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GWG10_RS01785	COG2801	Transposase and inactivated derivatives
GWG10_RS01835	COG0110	maltose O-acetyltransferase activity
GWG10_RS01845	COG2199	diguanylate cyclase activity
GWG10_RS01845	COG2203	Gaf domain
GWG10_RS01850	COG3932	Exopolysaccharide synthesis, ExoD
GWG10_RS01870	COG1733	regulation of RNA biosynthetic process
GWG10_RS01900	COG2226	methyltransferase
GWG10_RS01910	COG1494	fructose-1,6-bisphosphatase
GWG10_RS01920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GWG10_RS01925	COG5007	Belongs to the BolA IbaG family
GWG10_RS01935	COG2854	intermembrane phospholipid transfer
GWG10_RS01940	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GWG10_RS01945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GWG10_RS01950	COG1127	ABC transporter
GWG10_RS01955	COG0517	IMP dehydrogenase activity
GWG10_RS01955	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GWG10_RS01960	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GWG10_RS01970	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GWG10_RS01975	COG1137	ATPase activity
GWG10_RS01980	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GWG10_RS01990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWG10_RS01995	COG1660	Displays ATPase and GTPase activities
GWG10_RS02000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWG10_RS02020	COG3964	amidohydrolase
GWG10_RS02050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWG10_RS02055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWG10_RS02065	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GWG10_RS02070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GWG10_RS02075	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GWG10_RS02080	COG0723	plastoquinol--plastocyanin reductase activity
GWG10_RS02085	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GWG10_RS02090	COG2857	Cytochrome c1
GWG10_RS02095	COG0625	glutathione transferase activity
GWG10_RS02100	COG2969	positive regulation of protein catabolic process
GWG10_RS02105	COG2823	Periplasmic or secreted lipoprotein
GWG10_RS02110	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GWG10_RS02115	COG0792	nuclease activity
GWG10_RS02120	COG3107	peptidoglycan biosynthetic process
GWG10_RS02125	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GWG10_RS02135	COG2001	Belongs to the MraZ family
GWG10_RS02140	COG0275	rRNA processing
GWG10_RS02145	COG3116	cell division
GWG10_RS02150	COG0768	penicillin binding
GWG10_RS02155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GWG10_RS02160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GWG10_RS02165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWG10_RS02170	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GWG10_RS02175	COG0772	Belongs to the SEDS family
GWG10_RS02180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWG10_RS02185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWG10_RS02190	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GWG10_RS02195	COG0849	cell division
GWG10_RS02200	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GWG10_RS02205	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GWG10_RS02215	COG0653	protein targeting
GWG10_RS02225	COG0494	nUDIX hydrolase
GWG10_RS02230	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GWG10_RS02235	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GWG10_RS02245	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GWG10_RS02250	COG1459	type II secretion system
GWG10_RS02255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWG10_RS02280	COG2186	Transcriptional regulator
GWG10_RS02285	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GWG10_RS02290	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWG10_RS02295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWG10_RS02305	COG0840	transmembrane signaling receptor activity
GWG10_RS02310	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWG10_RS02315	COG1049	propionate catabolic process, 2-methylcitrate cycle
GWG10_RS02320	COG2200	EAL domain
GWG10_RS02330	COG1280	lysine exporter protein (LysE YggA)
GWG10_RS02340	COG0523	cobalamin synthesis protein
GWG10_RS02345	COG0477	Major facilitator Superfamily
GWG10_RS02360	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GWG10_RS02365	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GWG10_RS02410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GWG10_RS02420	COG1546	Belongs to the CinA family
GWG10_RS02425	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GWG10_RS02430	COG2137	regulation of response to DNA damage stimulus
GWG10_RS02435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWG10_RS02440	COG0527	aspartate kinase activity
GWG10_RS02445	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GWG10_RS02480	COG1686	Belongs to the peptidase S11 family
GWG10_RS02485	COG0586	Pfam SNARE associated Golgi protein
GWG10_RS02490	COG1253	flavin adenine dinucleotide binding
GWG10_RS02495	COG0525	valine-tRNA ligase activity
GWG10_RS02500	COG2927	DNA polymerase III (CHI subunit)
GWG10_RS02505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GWG10_RS02510	COG0795	lipopolysaccharide-transporting ATPase activity
GWG10_RS02515	COG0795	lipopolysaccharide-transporting ATPase activity
GWG10_RS02530	COG4974	Belongs to the 'phage' integrase family
GWG10_RS02600	COG0789	Transcriptional regulator
GWG10_RS02610	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWG10_RS02630	COG2801	Transposase and inactivated derivatives
GWG10_RS02645	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GWG10_RS02655	COG3039	Transposase
GWG10_RS02715	COG2801	Transposase and inactivated derivatives
GWG10_RS02735	COG0004	ammonium transporteR
GWG10_RS02740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWG10_RS02755	COG4968	Prepilin-type N-terminal cleavage methylation domain
GWG10_RS02760	COG0084	hydrolase, TatD family'
GWG10_RS02765	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWG10_RS02775	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GWG10_RS02780	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GWG10_RS02785	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GWG10_RS02795	COG4520	surface antigen
GWG10_RS02800	COG5002	protein histidine kinase activity
GWG10_RS02800	COG5001	Diguanylate cyclase
GWG10_RS02800	COG3447	MASE1 domain protein
GWG10_RS02810	COG0560	Phosphoserine phosphatase
GWG10_RS02825	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GWG10_RS02835	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GWG10_RS02840	COG0776	regulation of translation
GWG10_RS02855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWG10_RS02860	COG0735	belongs to the Fur family
GWG10_RS02880	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GWG10_RS02885	COG0513	Belongs to the DEAD box helicase family
GWG10_RS02890	COG3022	response to hydroperoxide
GWG10_RS02895	COG2805	Type II/IV secretion system protein
GWG10_RS02905	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWG10_RS02910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GWG10_RS02915	COG0762	integral membrane protein
GWG10_RS02920	COG1872	DUF167
GWG10_RS02940	COG3112	Uncharacterised protein family (UPF0231)
GWG10_RS02945	COG3835	regulator
GWG10_RS02950	COG2610	gluconate transmembrane transporter activity
GWG10_RS02955	COG1929	Belongs to the glycerate kinase type-1 family
GWG10_RS02970	COG0583	DNA-binding transcription factor activity
GWG10_RS02975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWG10_RS02990	COG0347	Belongs to the P(II) protein family
GWG10_RS03005	COG3842	ATPase activity
GWG10_RS03010	COG2837	iron assimilation
GWG10_RS03015	COG1438	arginine binding
GWG10_RS03020	COG1126	abc transporter atp-binding protein
GWG10_RS03025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG10_RS03030	COG4215	(ABC) transporter
GWG10_RS03035	COG4160	amino acid transport
GWG10_RS03040	COG0039	L-malate dehydrogenase activity
GWG10_RS03045	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GWG10_RS03050	COG1017	nitric oxide dioxygenase activity
GWG10_RS03050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWG10_RS03060	COG4536	flavin adenine dinucleotide binding
GWG10_RS03065	COG4137	Cytochrome C assembly protein
GWG10_RS03070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWG10_RS03075	COG0228	four-way junction DNA binding
GWG10_RS03080	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GWG10_RS03085	COG0336	Belongs to the RNA methyltransferase TrmD family
GWG10_RS03090	COG0335	large ribosomal subunit rRNA binding
GWG10_RS03105	COG1051	belongs to the nudix hydrolase family
GWG10_RS03115	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GWG10_RS03120	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GWG10_RS03125	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GWG10_RS03135	COG0583	DNA-binding transcription factor activity
GWG10_RS03140	COG0640	Transcriptional regulator
GWG10_RS03145	COG0268	Binds directly to 16S ribosomal RNA
GWG10_RS03150	COG0728	peptidoglycan biosynthetic process
GWG10_RS03155	COG0196	riboflavin kinase activity
GWG10_RS03160	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GWG10_RS03165	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GWG10_RS03170	COG1047	Peptidyl-prolyl cis-trans
GWG10_RS03175	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GWG10_RS03180	COG4968	Prepilin-type N-terminal cleavage methylation domain
GWG10_RS03235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWG10_RS03235	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GWG10_RS03250	COG1854	S-ribosylhomocysteine lyase activity
GWG10_RS03255	COG3706	GGDEF domain
GWG10_RS03260	COG0557	exoribonuclease II activity
GWG10_RS03265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWG10_RS03275	COG2153	protein acetylation
GWG10_RS03285	COG1914	H( )-stimulated, divalent metal cation uptake system
GWG10_RS03290	COG0360	Binds together with S18 to 16S ribosomal RNA
GWG10_RS03295	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GWG10_RS03300	COG0359	binds to the 23S rRNA
GWG10_RS03340	COG1238	metal cluster binding
GWG10_RS03345	COG0612	Peptidase, M16
GWG10_RS03350	COG2918	glutathione biosynthetic process
GWG10_RS03355	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GWG10_RS03360	COG1027	Aspartate ammonia-lyase
GWG10_RS03365	COG3030	protein affecting phage T7 exclusion by the F plasmid
GWG10_RS03370	COG0534	Mate efflux family protein
GWG10_RS03375	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GWG10_RS03380	COG0459	protein refolding
GWG10_RS03400	COG0564	pseudouridine synthase activity
GWG10_RS03405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWG10_RS03435	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GWG10_RS03445	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GWG10_RS03450	COG4208	sulfate ABC transporter
GWG10_RS03455	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GWG10_RS03460	COG0583	DNA-binding transcription factor activity
GWG10_RS03465	COG3397	chitin binding
GWG10_RS03495	COG1328	CTP reductase activity
GWG10_RS03500	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GWG10_RS03515	COG1448	Aminotransferase
GWG10_RS03520	COG2194	sulfuric ester hydrolase activity
GWG10_RS03540	COG1215	transferase activity, transferring glycosyl groups
GWG10_RS03545	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GWG10_RS03550	COG3118	belongs to the thioredoxin family
GWG10_RS03550	COG0457	Tetratricopeptide repeat
GWG10_RS03585	COG0513	Belongs to the DEAD box helicase family
GWG10_RS03590	COG0840	transmembrane signaling receptor activity
GWG10_RS03600	COG4166	transmembrane transport
GWG10_RS03615	COG1024	Enoyl-CoA hydratase
GWG10_RS03630	COG4221	oxidoreductase activity
GWG10_RS03635	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWG10_RS03640	COG0442	prolyl-tRNA aminoacylation
GWG10_RS03645	COG0840	transmembrane signaling receptor activity
GWG10_RS03650	COG0632	four-way junction helicase activity
GWG10_RS03655	COG2255	four-way junction helicase activity
GWG10_RS03665	COG1271	oxidase subunit
GWG10_RS03670	COG1294	oxidase, subunit
GWG10_RS03675	COG4890	Cyd operon protein YbgT
GWG10_RS03680	COG3790	cyd operon protein YbgE
GWG10_RS03685	COG0824	Thioesterase
GWG10_RS03690	COG0811	peptide transport
GWG10_RS03705	COG0823	Involved in the tonB-independent uptake of proteins
GWG10_RS03710	COG2885	chlorophyll binding
GWG10_RS03715	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GWG10_RS03790	COG0840	transmembrane signaling receptor activity
GWG10_RS03795	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GWG10_RS03805	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWG10_RS03810	COG1640	4-alpha-glucanotransferase
GWG10_RS03815	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GWG10_RS03845	COG2130	NADP-dependent
GWG10_RS03850	COG1846	Transcriptional regulator
GWG10_RS03880	COG0561	phosphatase activity
GWG10_RS03895	COG0733	neurotransmitter:sodium symporter activity
GWG10_RS03900	COG0733	neurotransmitter:sodium symporter activity
GWG10_RS03915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWG10_RS03930	COG1794	racemase activity, acting on amino acids and derivatives
GWG10_RS03940	COG1022	Amp-dependent synthetase and ligase
GWG10_RS03950	COG0456	acetyltransferase
GWG10_RS03965	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GWG10_RS03970	COG5002	protein histidine kinase activity
GWG10_RS03970	COG5001	Diguanylate cyclase
GWG10_RS04000	COG1902	pentaerythritol trinitrate reductase activity
GWG10_RS04015	COG2957	Belongs to the agmatine deiminase family
GWG10_RS04020	COG0154	amidase activity
GWG10_RS04025	COG2801	Transposase and inactivated derivatives
GWG10_RS04035	COG3039	Transposase
GWG10_RS04070	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
GWG10_RS04080	COG0577	efflux transmembrane transporter activity
GWG10_RS04080	COG1136	(ABC) transporter
GWG10_RS04085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG10_RS04090	COG0745	RESPONSE REGULATOR receiver
GWG10_RS04095	COG2205	protein histidine kinase activity
GWG10_RS04145	COG1280	lysine exporter protein (LysE YggA)
GWG10_RS04150	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GWG10_RS04165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG10_RS04195	COG0745	RESPONSE REGULATOR receiver
GWG10_RS04200	COG3104	oligopeptide transport
GWG10_RS04205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWG10_RS04210	COG1555	photosystem II stabilization
GWG10_RS04220	COG2350	Protein conserved in bacteria
GWG10_RS04225	COG2917	probably involved in intracellular septation
GWG10_RS04230	COG0076	glutamate decarboxylase activity
GWG10_RS04235	COG1272	protein, Hemolysin III
GWG10_RS04240	COG0569	domain protein
GWG10_RS04240	COG2985	domain, Protein
GWG10_RS04250	COG0477	Major facilitator Superfamily
GWG10_RS04255	COG0583	DNA-binding transcription factor activity
GWG10_RS04260	COG3227	Zinc metalloprotease (Elastase)
GWG10_RS04265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWG10_RS04270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWG10_RS04280	COG2731	YhcH YjgK YiaL family protein
GWG10_RS04290	COG0668	transmembrane transport
GWG10_RS04300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWG10_RS04320	COG3039	Transposase
GWG10_RS04355	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GWG10_RS04365	COG0488	(ABC) transporter
GWG10_RS04370	COG0517	IMP dehydrogenase activity
GWG10_RS04370	COG0516	GMP reductase activity
GWG10_RS04380	COG0784	Response regulator, receiver
GWG10_RS04380	COG0835	chemotaxis
GWG10_RS04385	COG2755	lipolytic protein G-D-S-L family
GWG10_RS04390	COG4181	ATPase activity
GWG10_RS04395	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GWG10_RS04400	COG1090	epimerase
GWG10_RS04405	COG2200	EAL domain
GWG10_RS04410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWG10_RS04415	COG2234	aminopeptidase activity
GWG10_RS04415	COG4935	Belongs to the peptidase S8 family
GWG10_RS04420	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GWG10_RS04425	COG3171	Protein conserved in bacteria
GWG10_RS04430	COG2066	Belongs to the glutaminase family
GWG10_RS04435	COG2897	thiosulfate sulfurtransferase activity
GWG10_RS04445	COG1132	(ABC) transporter
GWG10_RS04470	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
GWG10_RS04475	COG3300	MHYT domain
GWG10_RS04475	COG5001	Diguanylate cyclase
GWG10_RS04495	COG4628	conserved protein (DUF2132)
GWG10_RS04500	COG0688	phosphatidylethanolamine metabolic process
GWG10_RS04505	COG1162	GTPase activity
GWG10_RS04510	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GWG10_RS04545	COG1278	Cold shock
GWG10_RS04555	COG0840	transmembrane signaling receptor activity
GWG10_RS04560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWG10_RS04610	COG0848	biopolymer transport protein
GWG10_RS04615	COG0811	peptide transport
GWG10_RS04620	COG0811	peptide transport
GWG10_RS04630	COG4206	TonB-dependent receptor
GWG10_RS04635	COG4174	ABC transporter (Permease)
GWG10_RS04640	COG4239	(ABC) transporter, permease
GWG10_RS04650	COG0444	Belongs to the ABC transporter superfamily
GWG10_RS04655	COG4608	Belongs to the ABC transporter superfamily
GWG10_RS04660	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWG10_RS04665	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GWG10_RS04685	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GWG10_RS04715	COG0243	molybdopterin cofactor binding
GWG10_RS04720	COG1648	precorrin-2 dehydrogenase activity
GWG10_RS04720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWG10_RS04730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GWG10_RS04730	COG1116	anion transmembrane transporter activity
GWG10_RS04735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWG10_RS04740	COG1116	anion transmembrane transporter activity
GWG10_RS04745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWG10_RS04745	COG2146	nitrite reductase [NAD(P)H] activity
GWG10_RS04750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWG10_RS04750	COG2146	nitrite reductase [NAD(P)H] activity
GWG10_RS04755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWG10_RS04760	COG2313	pseudouridylate synthase activity
GWG10_RS04780	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWG10_RS04790	COG2966	Psort location CytoplasmicMembrane, score
GWG10_RS04795	COG3610	response to peptide
GWG10_RS04805	COG4175	Glycine betaine
GWG10_RS04810	COG4176	ABC-type proline glycine betaine transport system permease component
GWG10_RS04815	COG2113	Glycine betaine
GWG10_RS04825	COG0175	sulfate reduction
GWG10_RS04830	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWG10_RS04840	COG0384	phenazine biosynthesis protein PhzF
GWG10_RS04845	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GWG10_RS04860	COG0786	glutamate:sodium symporter activity
GWG10_RS04865	COG0252	asparaginase activity
GWG10_RS04870	COG3139	Protein of unknown function (DUF1315)
GWG10_RS04890	COG0616	signal peptide processing
GWG10_RS04895	COG1902	pentaerythritol trinitrate reductase activity
GWG10_RS04895	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWG10_RS04900	COG0778	Nitroreductase
GWG10_RS04910	COG0110	maltose O-acetyltransferase activity
GWG10_RS04915	COG2264	protein methyltransferase activity
GWG10_RS04920	COG0604	alcohol dehydrogenase
GWG10_RS04925	COG0583	DNA-binding transcription factor activity
GWG10_RS04930	COG1263	PTS System
GWG10_RS04930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWG10_RS04930	COG2190	(PTS) system
GWG10_RS04935	COG4145	pantothenate transmembrane transporter activity
GWG10_RS04940	COG3924	membrane
GWG10_RS04945	COG0439	Biotin carboxylase
GWG10_RS04950	COG0511	ligase activity, forming carbon-carbon bonds
GWG10_RS04955	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GWG10_RS04960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWG10_RS04975	COG3381	protein complex oligomerization
GWG10_RS04985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GWG10_RS04995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GWG10_RS05000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWG10_RS05000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWG10_RS05015	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GWG10_RS05020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWG10_RS05025	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GWG10_RS05030	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GWG10_RS05035	COG4172	Belongs to the ABC transporter superfamily
GWG10_RS05055	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GWG10_RS05060	COG0142	geranyltranstransferase activity
GWG10_RS05065	COG1722	exodeoxyribonuclease VII activity
GWG10_RS05070	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWG10_RS05075	COG1360	Flagellar Motor Protein
GWG10_RS05090	COG1534	Rna-binding protein
GWG10_RS05095	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GWG10_RS05105	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GWG10_RS05110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWG10_RS05115	COG0149	triose-phosphate isomerase activity
GWG10_RS05120	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWG10_RS05135	COG0779	Required for maturation of 30S ribosomal subunits
GWG10_RS05140	COG0195	Participates in both transcription termination and antitermination
GWG10_RS05145	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GWG10_RS05150	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GWG10_RS05155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GWG10_RS05160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GWG10_RS05165	COG1185	polyribonucleotide nucleotidyltransferase activity
GWG10_RS05170	COG2211	Major facilitator Superfamily
GWG10_RS05175	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GWG10_RS05180	COG1422	Protein of unknown function (DUF1090)
GWG10_RS05185	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWG10_RS05205	COG0312	modulator of DNA gyrase
GWG10_RS05210	COG0312	modulator of DNA gyrase
GWG10_RS05220	COG4974	Belongs to the 'phage' integrase family
GWG10_RS05225	COG1970	mechanosensitive ion channel activity
GWG10_RS05235	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GWG10_RS05240	COG0789	Transcriptional regulator
GWG10_RS05255	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWG10_RS05265	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GWG10_RS05270	COG0321	lipoyl(octanoyl) transferase activity
GWG10_RS05275	COG2921	Belongs to the UPF0250 family
GWG10_RS05280	COG1686	Belongs to the peptidase S11 family
GWG10_RS05285	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GWG10_RS05290	COG2951	lytic endotransglycosylase activity
GWG10_RS05295	COG0772	Belongs to the SEDS family
GWG10_RS05300	COG0768	penicillin binding
GWG10_RS05305	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GWG10_RS05310	COG0799	negative regulation of ribosome biogenesis
GWG10_RS05315	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GWG10_RS05340	COG0495	leucyl-tRNA aminoacylation
GWG10_RS05345	COG2888	peptidyl-tyrosine sulfation
GWG10_RS05350	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GWG10_RS05355	COG4535	Mg2 and Co2 transporter CorC
GWG10_RS05360	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GWG10_RS05365	COG1702	phosphate starvation-inducible protein PhoH
GWG10_RS05370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWG10_RS05375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWG10_RS05380	COG1335	isochorismatase
GWG10_RS05385	COG1278	Cold shock
GWG10_RS05400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWG10_RS05405	COG2199	diguanylate cyclase activity
GWG10_RS05415	COG2199	diguanylate cyclase activity
GWG10_RS05425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWG10_RS05440	COG1464	Belongs to the NlpA lipoprotein family
GWG10_RS05445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWG10_RS05450	COG2011	ABC-type metal ion transport system permease component
GWG10_RS05455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GWG10_RS05465	COG0516	GMP reductase activity
GWG10_RS05470	COG4067	protein conserved in archaea
GWG10_RS05470	COG0189	ligase activity
GWG10_RS05490	COG0300	oxidoreductase activity
GWG10_RS05510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWG10_RS05515	COG3214	Protein conserved in bacteria
GWG10_RS05530	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GWG10_RS05535	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GWG10_RS05540	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GWG10_RS05545	COG1053	succinate dehydrogenase
GWG10_RS05555	COG0584	glycerophosphoryl diester phosphodiesterase
GWG10_RS05560	COG3264	Mechanosensitive ion channel
GWG10_RS05560	COG1511	domain protein
GWG10_RS05570	COG0739	heme binding
GWG10_RS05585	COG0583	DNA-binding transcription factor activity
GWG10_RS05600	COG0583	DNA-binding transcription factor activity
GWG10_RS05605	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GWG10_RS05635	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GWG10_RS05640	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GWG10_RS05650	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GWG10_RS05655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GWG10_RS05660	COG0546	phosphoglycolate phosphatase activity
GWG10_RS05665	COG0180	Tryptophanyl-tRNA synthetase
GWG10_RS05680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWG10_RS05690	COG1012	belongs to the aldehyde dehydrogenase family
GWG10_RS05705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWG10_RS05730	COG0471	metal ion transport
GWG10_RS05730	COG0490	domain, Protein
GWG10_RS05780	COG0012	GTP binding
GWG10_RS05785	COG0193	aminoacyl-tRNA hydrolase activity
GWG10_RS05790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWG10_RS05800	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GWG10_RS05805	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GWG10_RS05810	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GWG10_RS05815	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GWG10_RS05820	COG2890	protein-(glutamine-N5) methyltransferase activity
GWG10_RS05830	COG2912	Transglutaminase-like superfamily
GWG10_RS05835	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GWG10_RS05840	COG1301	dicarboxylic acid transport
GWG10_RS05850	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GWG10_RS05865	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GWG10_RS05870	COG1115	amino acid carrier protein
GWG10_RS05890	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GWG10_RS05900	COG0189	ligase activity
GWG10_RS05905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GWG10_RS05915	COG3091	SprT-like family
GWG10_RS05930	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GWG10_RS05945	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GWG10_RS05950	COG0739	heme binding
GWG10_RS05955	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWG10_RS05960	COG3385	transposase activity
GWG10_RS05975	COG1881	PFAM PEBP family protein
GWG10_RS05985	COG0583	DNA-binding transcription factor activity
GWG10_RS05995	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GWG10_RS06005	COG0583	DNA-binding transcription factor activity
GWG10_RS06010	COG1028	Short-chain dehydrogenase reductase Sdr
GWG10_RS06015	COG0616	signal peptide processing
GWG10_RS06020	COG3724	N-succinylarginine dihydrolase activity
GWG10_RS06040	COG0840	transmembrane signaling receptor activity
GWG10_RS06050	COG2971	BadF BadG BcrA BcrD
GWG10_RS06060	COG4608	Belongs to the ABC transporter superfamily
GWG10_RS06065	COG0444	Belongs to the ABC transporter superfamily
GWG10_RS06070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWG10_RS06085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWG10_RS06095	COG0640	Transcriptional regulator
GWG10_RS06100	COG0798	PFAM Bile acid sodium symporter
GWG10_RS06105	COG1393	Belongs to the ArsC family
GWG10_RS06120	COG1677	Flagellar hook-basal body complex protein FliE
GWG10_RS06130	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWG10_RS06185	COG1684	flagellar biosynthetic protein fliR
GWG10_RS06195	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWG10_RS06220	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GWG10_RS06225	COG2198	Histidine kinase
GWG10_RS06225	COG0643	Histidine kinase
GWG10_RS06225	COG0784	Response regulator, receiver
GWG10_RS06230	COG2201	protein-glutamate methylesterase activity
GWG10_RS06235	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWG10_RS06240	COG1360	Flagellar Motor Protein
GWG10_RS06245	COG1192	Involved in chromosome partitioning
GWG10_RS06255	COG0835	chemotaxis
GWG10_RS06270	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWG10_RS06275	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWG10_RS06280	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWG10_RS06285	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GWG10_RS06290	COG1138	Cytochrome C-type biogenesis protein
GWG10_RS06295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWG10_RS06305	COG0457	Tetratricopeptide repeat
GWG10_RS06320	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GWG10_RS06325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWG10_RS06325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWG10_RS06340	COG0259	pyridoxamine-phosphate oxidase activity
GWG10_RS06370	COG3153	acetyltransferase
GWG10_RS06385	COG0800	Aldolase
GWG10_RS06455	COG5642	Protein of unknown function (DUF2384)
GWG10_RS06460	COG2850	peptidyl-arginine hydroxylation
GWG10_RS06565	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GWG10_RS06570	COG2867	negative regulation of translational initiation
GWG10_RS06580	COG0702	epimerase
GWG10_RS06585	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWG10_RS06710	COG0640	Transcriptional regulator
GWG10_RS06725	COG4383	Mu-like prophage protein gp29
GWG10_RS06745	COG4388	Caudovirus prohead serine protease
GWG10_RS06750	COG4397	Mu-like prophage major head subunit gpT
GWG10_RS06835	COG0564	pseudouridine synthase activity
GWG10_RS06840	COG1957	nucleoside hydrolase
GWG10_RS06865	COG1280	lysine exporter protein (LysE YggA)
GWG10_RS06875	COG3263	regulation of cellular component size
GWG10_RS06885	COG1876	peptidase activity
GWG10_RS06890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWG10_RS06895	COG1393	Belongs to the ArsC family
GWG10_RS06900	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWG10_RS06915	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWG10_RS06930	COG3069	C4-dicarboxylate transmembrane transporter activity
GWG10_RS06935	COG1473	amidohydrolase
GWG10_RS06945	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GWG10_RS06950	COG0017	Asparaginyl-tRNA synthetase
GWG10_RS06970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GWG10_RS06975	COG0156	8-amino-7-oxononanoate synthase activity
GWG10_RS06980	COG2226	methyltransferase
GWG10_RS06980	COG1073	alpha beta
GWG10_RS06985	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GWG10_RS06990	COG0501	Belongs to the peptidase M48B family
GWG10_RS06995	COG3217	Mosc domain protein beta barrel domain protein
GWG10_RS06995	COG0633	Ferredoxin
GWG10_RS06995	COG3217	Mosc domain protein beta barrel domain protein
GWG10_RS06995	COG0633	Ferredoxin
GWG10_RS07005	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GWG10_RS07005	COG0674	pyruvate-flavodoxin oxidoreductase activity
GWG10_RS07005	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GWG10_RS07005	COG1013	pyruvate-flavodoxin oxidoreductase activity
GWG10_RS07010	COG2841	Protein conserved in bacteria
GWG10_RS07020	COG0534	Mate efflux family protein
GWG10_RS07055	COG1309	transcriptional regulator
GWG10_RS07070	COG0791	NLP P60 protein
GWG10_RS07075	COG0583	DNA-binding transcription factor activity
GWG10_RS07100	COG0500	methyltransferase
GWG10_RS07105	COG4106	trans-aconitate 2-methyltransferase activity
GWG10_RS07110	COG1801	Protein of unknown function DUF72
GWG10_RS07115	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GWG10_RS07120	COG0217	transcriptional regulatory protein
GWG10_RS07125	COG2194	sulfuric ester hydrolase activity
GWG10_RS07130	COG1940	carbohydrate kinase activity
GWG10_RS07130	COG1846	Transcriptional regulator
GWG10_RS07135	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWG10_RS07140	COG0363	glucosamine-6-phosphate deaminase activity
GWG10_RS07145	COG1263	PTS System
GWG10_RS07145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWG10_RS07145	COG2190	(PTS) system
GWG10_RS07155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWG10_RS07160	COG0735	belongs to the Fur family
GWG10_RS07170	COG0716	FMN binding
GWG10_RS07185	COG0596	Alpha beta hydrolase
GWG10_RS07190	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GWG10_RS07195	COG0033	Phosphoglucomutase
GWG10_RS07205	COG1846	Transcriptional regulator
GWG10_RS07210	COG2951	lytic endotransglycosylase activity
GWG10_RS07215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GWG10_RS07220	COG4136	ATPase activity
GWG10_RS07230	COG4134	Bacterial extracellular solute-binding protein
GWG10_RS07235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWG10_RS07240	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWG10_RS07250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWG10_RS07260	COG0729	surface antigen
GWG10_RS07265	COG2911	Protein conserved in bacteria
GWG10_RS07285	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GWG10_RS07295	COG0741	lytic transglycosylase activity
GWG10_RS07310	COG1607	acyl-coa hydrolase
GWG10_RS07325	COG1388	LysM domain
GWG10_RS07325	COG0741	lytic transglycosylase activity
GWG10_RS07330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWG10_RS07335	COG2226	methyltransferase
GWG10_RS07340	COG0328	RNA-DNA hybrid ribonuclease activity
GWG10_RS07345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWG10_RS07365	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GWG10_RS07370	COG0121	glutamine amidotransferase
GWG10_RS07380	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GWG10_RS07405	COG2197	response regulator
GWG10_RS07410	COG3850	Histidine kinase
GWG10_RS07415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GWG10_RS07420	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWG10_RS07420	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWG10_RS07430	COG0243	molybdopterin cofactor binding
GWG10_RS07435	COG0437	4 iron, 4 sulfur cluster binding
GWG10_RS07440	COG0348	domain, Protein
GWG10_RS07450	COG3005	denitrification pathway
GWG10_RS07455	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWG10_RS07460	COG0315	cyclic pyranopterin monophosphate synthase activity
GWG10_RS07465	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GWG10_RS07470	COG0314	molybdopterin synthase activity
GWG10_RS07485	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GWG10_RS07490	COG2267	carboxylic ester hydrolase activity
GWG10_RS07495	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWG10_RS07505	COG0302	gtp cyclohydrolase
GWG10_RS07515	COG0675	Transposase, IS605 OrfB family
GWG10_RS07575	COG4644	lycopene metabolic process
GWG10_RS07590	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GWG10_RS07600	COG0583	DNA-binding transcription factor activity
GWG10_RS07615	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GWG10_RS07630	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWG10_RS07635	COG1166	arginine decarboxylase activity
GWG10_RS07640	COG3385	transposase activity
GWG10_RS07685	COG0675	Transposase, IS605 OrfB family
GWG10_RS07695	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWG10_RS07700	COG1187	pseudouridine synthase activity
GWG10_RS07705	COG2807	transmembrane transport
GWG10_RS07715	COG0583	DNA-binding transcription factor activity
GWG10_RS07735	COG2979	Protein of unknown function (DUF533)
GWG10_RS07745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWG10_RS07750	COG1271	oxidase subunit
GWG10_RS07755	COG1294	oxidase, subunit
GWG10_RS07765	COG2814	Major facilitator Superfamily
GWG10_RS07770	COG0656	L-ascorbic acid biosynthetic process
GWG10_RS07790	COG0583	DNA-binding transcription factor activity
GWG10_RS07795	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GWG10_RS07800	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GWG10_RS07815	COG2271	Major facilitator Superfamily
GWG10_RS07820	COG1349	DNA-binding transcription factor activity
GWG10_RS07830	COG0584	glycerophosphoryl diester phosphodiesterase
GWG10_RS07835	COG3385	transposase activity
GWG10_RS07840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWG10_RS07845	COG1605	Chorismate mutase
GWG10_RS07845	COG0287	Prephenate dehydrogenase
GWG10_RS07855	COG3085	chromosome segregation
GWG10_RS07860	COG4574	serine-type endopeptidase inhibitor activity
GWG10_RS07880	COG1770	oligopeptidase
GWG10_RS07885	COG4771	TonB-dependent receptor
GWG10_RS07890	COG3083	sulfuric ester hydrolase activity
GWG10_RS07895	COG3082	Protein of unknown function (DUF1414)
GWG10_RS07900	COG3081	Nucleoid-associated protein
GWG10_RS07910	COG1175	transmembrane transport
GWG10_RS07915	COG3833	ABC-type maltose transport systems, permease component
GWG10_RS07920	COG3842	ATPase activity
GWG10_RS07930	COG0596	Alpha beta hydrolase
GWG10_RS07945	COG0425	Belongs to the sulfur carrier protein TusA family
GWG10_RS07950	COG4783	chaperone-mediated protein folding
GWG10_RS07960	COG1393	Belongs to the ArsC family
GWG10_RS07975	COG0675	Transposase, IS605 OrfB family
GWG10_RS07985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG10_RS07990	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWG10_RS07995	COG2431	L-lysine efflux transmembrane transporter activity
GWG10_RS08005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG10_RS08015	COG4160	amino acid transport
GWG10_RS08030	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GWG10_RS08040	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWG10_RS08045	COG0628	permease
GWG10_RS08050	COG2373	Large extracellular alpha-helical protein
GWG10_RS08055	COG4953	penicillin-binding protein 1C
GWG10_RS08065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWG10_RS08065	COG0301	tRNA thio-modification
GWG10_RS08080	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWG10_RS08085	COG1334	flagellar protein FlaG
GWG10_RS08115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWG10_RS08125	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GWG10_RS08140	COG0346	lactoylglutathione lyase activity
GWG10_RS08145	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GWG10_RS08150	COG4660	Part of a membrane complex involved in electron transport
GWG10_RS08155	COG4659	FMN binding
GWG10_RS08160	COG4658	electron transport chain
GWG10_RS08170	COG2878	Part of a membrane complex involved in electron transport
GWG10_RS08175	COG4657	Part of a membrane complex involved in electron transport
GWG10_RS08180	COG0675	Transposase, IS605 OrfB family
GWG10_RS08190	COG0697	spore germination
GWG10_RS08220	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GWG10_RS08235	COG0436	Aminotransferase
GWG10_RS08245	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GWG10_RS08250	COG2027	D-alanyl-D-alanine carboxypeptidase
GWG10_RS08255	COG1061	Type III restriction enzyme res subunit
GWG10_RS08260	COG1566	PFAM secretion protein HlyD family protein
GWG10_RS08275	COG0675	Transposase, IS605 OrfB family
GWG10_RS08280	COG3264	Mechanosensitive ion channel
GWG10_RS08280	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GWG10_RS08285	COG1966	Carbon starvation protein
GWG10_RS08290	COG3279	Response regulator of the LytR AlgR family
GWG10_RS08295	COG3275	phosphorelay sensor kinase activity
GWG10_RS08305	COG1454	alcohol dehydrogenase
GWG10_RS08305	COG1012	belongs to the aldehyde dehydrogenase family
GWG10_RS08310	COG2095	MarC family integral membrane protein
GWG10_RS08320	COG0601	transmembrane transport
GWG10_RS08325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWG10_RS08330	COG0444	Belongs to the ABC transporter superfamily
GWG10_RS08340	COG0861	Integral membrane protein TerC family
GWG10_RS08345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWG10_RS08355	COG1301	dicarboxylic acid transport
GWG10_RS08375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GWG10_RS08380	COG0582	viral genome integration into host DNA
GWG10_RS08410	COG2974	May be involved in recombination
GWG10_RS08445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWG10_RS08735	COG0537	adenosine 5'-monophosphoramidase activity
GWG10_RS08770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWG10_RS08775	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWG10_RS08790	COG2354	Protein conserved in bacteria
GWG10_RS08795	COG1164	Oligoendopeptidase f
GWG10_RS08800	COG1164	Oligoendopeptidase f
GWG10_RS08805	COG3150	esterase
GWG10_RS08810	COG1252	NADH dehydrogenase
GWG10_RS08815	COG0393	Putative heavy-metal-binding
GWG10_RS08820	COG1368	sulfuric ester hydrolase activity
GWG10_RS08830	COG0527	aspartate kinase activity
GWG10_RS08835	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GWG10_RS08835	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWG10_RS08840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWG10_RS08865	COG0583	DNA-binding transcription factor activity
GWG10_RS08870	COG1620	l-lactate permease
GWG10_RS08875	COG0247	lactate metabolic process
GWG10_RS08880	COG1139	Iron-sulfur cluster binding protein
GWG10_RS08905	COG1136	(ABC) transporter
GWG10_RS08925	COG2814	Major facilitator Superfamily
GWG10_RS08950	COG0672	)-iron permease
GWG10_RS08985	COG2308	Evidence 4 Homologs of previously reported genes of
GWG10_RS09000	COG0659	secondary active sulfate transmembrane transporter activity
GWG10_RS09020	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GWG10_RS09025	COG0326	Molecular chaperone. Has ATPase activity
GWG10_RS09030	COG0563	adenylate kinase activity
GWG10_RS09035	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GWG10_RS09040	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GWG10_RS09045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWG10_RS09050	COG0840	transmembrane signaling receptor activity
GWG10_RS09065	COG3300	MHYT domain
GWG10_RS09065	COG5001	Diguanylate cyclase
GWG10_RS09090	COG1021	2,3-dihydroxybenzoate-AMP ligase
GWG10_RS09095	COG3433	isochorismatase activity
GWG10_RS09095	COG1535	isochorismatase
GWG10_RS09100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWG10_RS09105	COG1028	Short-chain dehydrogenase reductase Sdr
GWG10_RS09115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWG10_RS09130	COG1120	ATPase activity
GWG10_RS09135	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWG10_RS09140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWG10_RS09145	COG4771	TonB-dependent receptor
GWG10_RS09185	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GWG10_RS09190	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GWG10_RS09195	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWG10_RS09200	COG0861	Integral membrane protein TerC family
GWG10_RS09215	COG1022	Amp-dependent synthetase and ligase
GWG10_RS09220	COG0295	cytidine deaminase activity
GWG10_RS09225	COG1346	cytolysis
GWG10_RS09230	COG1380	Effector of murein hydrolase LrgA
GWG10_RS09235	COG3345	alpha-galactosidase
GWG10_RS09245	COG2925	Exonuclease
GWG10_RS09250	COG0582	viral genome integration into host DNA
GWG10_RS09340	COG1846	Transcriptional regulator
GWG10_RS09355	COG3646	Phage regulatory protein
GWG10_RS09405	COG4626	Terminase
GWG10_RS09405	COG1802	Transcriptional regulator
GWG10_RS09515	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWG10_RS09520	COG0392	lysyltransferase activity
GWG10_RS09520	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GWG10_RS09535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWG10_RS09540	COG0436	Aminotransferase
GWG10_RS09545	COG0583	DNA-binding transcription factor activity
GWG10_RS09550	COG2160	L-arabinose isomerase activity
GWG10_RS09560	COG1069	ribulokinase activity
GWG10_RS09565	COG1879	ABC-type sugar transport system periplasmic component
GWG10_RS09570	COG1129	ABC transporter
GWG10_RS09575	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWG10_RS09585	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWG10_RS09590	COG0254	rRNA binding
GWG10_RS09605	COG1451	nucleotide metabolic process
GWG10_RS09620	COG3069	C4-dicarboxylate transmembrane transporter activity
GWG10_RS09630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWG10_RS09630	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GWG10_RS09635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWG10_RS09655	COG2009	succinate dehydrogenase
GWG10_RS09660	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GWG10_RS09675	COG0567	Dehydrogenase, E1 component
GWG10_RS09680	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWG10_RS09685	COG0045	succinate-CoA ligase (ADP-forming) activity
GWG10_RS09690	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GWG10_RS09695	COG2801	Transposase and inactivated derivatives
GWG10_RS09710	COG2983	Belongs to the UPF0260 family
GWG10_RS09715	COG1882	Formate acetyltransferase
GWG10_RS09720	COG2116	formate transmembrane transporter activity
GWG10_RS09725	COG1944	ATP diphosphatase activity
GWG10_RS09735	COG2076	Multidrug Resistance protein
GWG10_RS09740	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GWG10_RS09745	COG1278	Cold shock
GWG10_RS09750	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GWG10_RS09755	COG0542	response to heat
GWG10_RS09760	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GWG10_RS09765	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GWG10_RS09770	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GWG10_RS09775	COG3134	Outer membrane lipoprotein
GWG10_RS09780	COG3706	GGDEF domain
GWG10_RS09785	COG0492	ferredoxin-NADP+ reductase activity
GWG10_RS09790	COG0686	Belongs to the AlaDH PNT family
GWG10_RS09800	COG1674	ftsk spoiiie
GWG10_RS09800	COG0531	amino acid
GWG10_RS09805	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWG10_RS09810	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GWG10_RS09815	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GWG10_RS09820	COG1286	toxin biosynthetic process
GWG10_RS09825	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GWG10_RS09830	COG2723	6-phospho-beta-galactosidase activity
GWG10_RS09835	COG1263	PTS System
GWG10_RS09835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWG10_RS09840	COG1609	Transcriptional regulator
GWG10_RS09850	COG4172	Belongs to the ABC transporter superfamily
GWG10_RS09860	COG4171	peptide transport system, permease
GWG10_RS09875	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GWG10_RS09880	COG1842	Phage shock protein A
GWG10_RS09895	COG3106	COG3106 Predicted ATPase
GWG10_RS09900	COG3768	UPF0283 membrane protein
GWG10_RS09910	COG2154	pterin-4-alpha-carbinolamine dehydratase
GWG10_RS09930	COG2885	chlorophyll binding
GWG10_RS09940	COG1570	exodeoxyribonuclease VII activity
GWG10_RS09950	COG1874	Beta-galactosidase
GWG10_RS09950	COG0366	Alpha amylase catalytic
GWG10_RS09960	COG0517	IMP dehydrogenase activity
GWG10_RS09960	COG0516	GMP reductase activity
GWG10_RS09965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWG10_RS09965	COG0519	Catalyzes the synthesis of GMP from XMP
GWG10_RS09970	COG3039	Transposase
GWG10_RS09995	COG1846	Transcriptional regulator
GWG10_RS10010	COG0500	methyltransferase
GWG10_RS10020	COG2062	phosphohistidine phosphatase, SixA
GWG10_RS10030	COG0697	spore germination
GWG10_RS10045	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GWG10_RS10050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GWG10_RS10060	COG4591	ABC-type transport system involved in lipoprotein release permease component
GWG10_RS10065	COG1136	(ABC) transporter
GWG10_RS10070	COG4591	ABC-type transport system involved in lipoprotein release permease component
GWG10_RS10075	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GWG10_RS10085	COG0544	peptidyl-prolyl cis-trans isomerase activity
GWG10_RS10090	COG0740	serine-type endopeptidase activity
GWG10_RS10095	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GWG10_RS10100	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GWG10_RS10105	COG0776	regulation of translation
GWG10_RS10110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWG10_RS10115	COG0488	(ABC) transporter
GWG10_RS10120	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWG10_RS10125	COG3162	membrane
GWG10_RS10140	COG1024	Enoyl-CoA hydratase
GWG10_RS10145	COG1115	amino acid carrier protein
GWG10_RS10155	COG3228	Belongs to the MtfA family
GWG10_RS10160	COG1584	GPR1 FUN34 yaaH family protein
GWG10_RS10185	COG1024	Enoyl-CoA hydratase
GWG10_RS10190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWG10_RS10195	COG1960	acyl-CoA dehydrogenase activity
GWG10_RS10205	COG1960	acyl-CoA dehydrogenase activity
GWG10_RS10210	COG1024	Enoyl-CoA hydratase
GWG10_RS10215	COG1024	Enoyl-CoA hydratase
GWG10_RS10225	COG1028	Short-chain dehydrogenase reductase Sdr
GWG10_RS10235	COG0730	response to heat
GWG10_RS10270	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWG10_RS10275	COG3328	transposase activity
GWG10_RS10285	COG3039	Transposase
GWG10_RS10315	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWG10_RS10320	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWG10_RS10325	COG1129	ABC transporter
GWG10_RS10330	COG1879	ABC-type sugar transport system periplasmic component
GWG10_RS10335	COG0583	DNA-binding transcription factor activity
GWG10_RS10350	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GWG10_RS10355	COG0243	molybdopterin cofactor binding
GWG10_RS10365	COG0583	DNA-binding transcription factor activity
GWG10_RS10370	COG2723	6-phospho-beta-galactosidase activity
GWG10_RS10380	COG0583	DNA-binding transcription factor activity
GWG10_RS10395	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GWG10_RS10400	COG0673	inositol 2-dehydrogenase activity
GWG10_RS10405	COG0583	DNA-binding transcription factor activity
GWG10_RS10415	COG1560	Kdo2-lipid A biosynthetic process
GWG10_RS10420	COG1560	Kdo2-lipid A biosynthetic process
GWG10_RS10435	COG0417	DNA replication proofreading
GWG10_RS10465	COG0534	Mate efflux family protein
GWG10_RS10475	COG0307	riboflavin synthase, alpha
GWG10_RS10490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWG10_RS10495	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GWG10_RS10500	COG0697	spore germination
GWG10_RS10505	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GWG10_RS10535	COG0675	Transposase, IS605 OrfB family
GWG10_RS10540	COG2996	Protein conserved in bacteria
GWG10_RS10555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWG10_RS10560	COG3099	Belongs to the UPF0263 family
GWG10_RS10565	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GWG10_RS10570	COG2894	cell division
GWG10_RS10575	COG0850	regulation of cytokinetic process
GWG10_RS10580	COG3100	YcgL domain-containing protein
GWG10_RS10585	COG2951	lytic endotransglycosylase activity
GWG10_RS10590	COG1760	l-serine dehydratase
GWG10_RS10595	COG1760	l-serine dehydratase
GWG10_RS10600	COG3123	guanosine phosphorylase activity
GWG10_RS10605	COG1301	dicarboxylic acid transport
GWG10_RS10620	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GWG10_RS10625	COG2067	long-chain fatty acid transport protein
GWG10_RS10630	COG2067	long-chain fatty acid transport protein
GWG10_RS10640	COG1595	DNA-templated transcription, initiation
GWG10_RS10670	COG0714	Associated with various cellular activities
GWG10_RS10675	COG0183	Belongs to the thiolase family
GWG10_RS10680	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWG10_RS10680	COG1024	Enoyl-CoA hydratase
GWG10_RS10690	COG4681	YaeQ
GWG10_RS10710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWG10_RS10725	COG3134	Outer membrane lipoprotein
GWG10_RS10730	COG0318	PFAM AMP-dependent synthetase and ligase
GWG10_RS10765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GWG10_RS10765	COG0140	phosphoribosyl-ATP diphosphatase activity
GWG10_RS10770	COG0107	imidazoleglycerol-phosphate synthase activity
GWG10_RS10775	COG0784	Response regulator, receiver
GWG10_RS10775	COG2205	protein histidine kinase activity
GWG10_RS10775	COG2198	Histidine kinase
GWG10_RS10785	COG3437	response regulator, receiver
GWG10_RS10790	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GWG10_RS10795	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GWG10_RS10800	COG0131	Imidazoleglycerol-phosphate dehydratase
GWG10_RS10800	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GWG10_RS10805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GWG10_RS10810	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GWG10_RS10815	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GWG10_RS10825	COG1199	ATP-dependent helicase activity
GWG10_RS10830	COG1214	PFAM Peptidase M22, glycoprotease
GWG10_RS10840	COG0596	Alpha beta hydrolase
GWG10_RS10845	COG0318	PFAM AMP-dependent synthetase and ligase
GWG10_RS10860	COG0697	spore germination
GWG10_RS10870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWG10_RS10875	COG2832	Protein of unknown function (DUF454)
GWG10_RS10880	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GWG10_RS10890	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GWG10_RS10895	COG0583	DNA-binding transcription factor activity
GWG10_RS10910	COG2197	response regulator
GWG10_RS10915	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GWG10_RS10915	COG0617	tRNA 3'-terminal CCA addition
GWG10_RS10915	COG0517	IMP dehydrogenase activity
GWG10_RS10920	COG1643	Atp-dependent helicase
GWG10_RS10930	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GWG10_RS10945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWG10_RS10950	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GWG10_RS10955	COG0709	Synthesizes selenophosphate from selenide and ATP
GWG10_RS10970	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GWG10_RS10975	COG0840	transmembrane signaling receptor activity
GWG10_RS10980	COG1254	Belongs to the acylphosphatase family
GWG10_RS10990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWG10_RS10990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWG10_RS10995	COG0489	protein tyrosine kinase activity
GWG10_RS11000	COG0572	uridine kinase
GWG10_RS11005	COG0717	Belongs to the dCTP deaminase family
GWG10_RS11010	COG0306	phosphate transporter
GWG10_RS11015	COG1530	ribonuclease E activity
GWG10_RS11020	COG0564	pseudouridine synthase activity
GWG10_RS11035	COG1399	metal-binding, possibly nucleic acid-binding protein
GWG10_RS11040	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GWG10_RS11045	COG0416	fatty acid biosynthetic process
GWG10_RS11050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWG10_RS11060	COG1028	Short-chain dehydrogenase reductase Sdr
GWG10_RS11065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWG10_RS11070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWG10_RS11075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GWG10_RS11080	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GWG10_RS11085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GWG10_RS11090	COG0470	DNA polymerase III
GWG10_RS11095	COG0084	hydrolase, TatD family'
GWG10_RS11115	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GWG10_RS11115	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWG10_RS11120	COG3008	intermembrane lipid transfer
GWG10_RS11125	COG2995	paraquat-inducible protein a
GWG10_RS11135	COG3141	response to X-ray
GWG10_RS11185	COG1074	ATP-dependent DNA helicase activity
GWG10_RS11190	COG3328	transposase activity
GWG10_RS11210	COG0583	DNA-binding transcription factor activity
GWG10_RS11235	COG0633	Ferredoxin
GWG10_RS11240	COG0789	Transcriptional regulator
GWG10_RS11250	COG0640	Transcriptional regulator
GWG10_RS11270	COG1937	Protein conserved in bacteria
GWG10_RS11275	COG1230	cation diffusion facilitator family transporter
GWG10_RS11280	COG0640	Transcriptional regulator
GWG10_RS11415	COG1067	ATP-dependent peptidase activity
GWG10_RS11420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWG10_RS11445	COG0116	Belongs to the methyltransferase superfamily
GWG10_RS11445	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GWG10_RS11455	COG0167	dihydroorotate dehydrogenase activity
GWG10_RS11460	COG2902	Dehydrogenase
GWG10_RS11470	COG0308	aminopeptidase N
GWG10_RS11480	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GWG10_RS11485	COG1956	GAF domain-containing protein
GWG10_RS11500	COG3278	Belongs to the heme-copper respiratory oxidase family
GWG10_RS11515	COG2010	Cytochrome c
GWG10_RS11525	COG2217	Heavy metal translocating P-type atpase
GWG10_RS11540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWG10_RS11545	COG0589	response to stress
GWG10_RS11550	COG0037	tRNA processing
GWG10_RS11565	COG0625	glutathione transferase activity
GWG10_RS11570	COG1869	D-ribose catabolic process
GWG10_RS11575	COG1129	ABC transporter
GWG10_RS11580	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWG10_RS11585	COG1879	ABC-type sugar transport system periplasmic component
GWG10_RS11590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWG10_RS11595	COG1609	Transcriptional regulator
GWG10_RS11630	COG0776	regulation of translation
GWG10_RS11635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWG10_RS11635	COG0072	phenylalanine-tRNA ligase activity
GWG10_RS11640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GWG10_RS11645	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GWG10_RS11650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GWG10_RS11655	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GWG10_RS11660	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GWG10_RS11695	COG0675	Transposase, IS605 OrfB family
GWG10_RS11720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWG10_RS11730	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWG10_RS11735	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWG10_RS11740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWG10_RS11745	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GWG10_RS11750	COG3313	Fe-S protein
GWG10_RS11755	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWG10_RS11755	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWG10_RS11755	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GWG10_RS11760	COG1105	Belongs to the carbohydrate kinase PfkB family
GWG10_RS11765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWG10_RS11765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWG10_RS11770	COG1609	Transcriptional regulator
GWG10_RS11775	COG0814	amino acid
GWG10_RS11785	COG5654	RES domain protein
GWG10_RS11790	COG0513	Belongs to the DEAD box helicase family
GWG10_RS11800	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GWG10_RS11805	COG2890	protein-(glutamine-N5) methyltransferase activity
GWG10_RS11810	COG2840	Smr protein MutS2
GWG10_RS11845	COG2824	Alkylphosphonate utilization operon protein PhnA
GWG10_RS11855	COG1280	lysine exporter protein (LysE YggA)
GWG10_RS11910	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GWG10_RS11915	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GWG10_RS11925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWG10_RS11930	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GWG10_RS11940	COG0205	6-phosphofructokinase activity
GWG10_RS11950	COG1473	amidohydrolase
GWG10_RS11955	COG1011	Hydrolase
GWG10_RS11960	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GWG10_RS12005	COG3593	DNA synthesis involved in DNA repair
GWG10_RS12020	COG0583	DNA-binding transcription factor activity
GWG10_RS12025	COG0730	response to heat
GWG10_RS12035	COG1181	Belongs to the D-alanine--D-alanine ligase family
GWG10_RS12045	COG0386	Belongs to the glutathione peroxidase family
GWG10_RS12050	COG0513	Belongs to the DEAD box helicase family
GWG10_RS12085	COG2329	Antibiotic biosynthesis monooxygenase
GWG10_RS12090	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GWG10_RS12120	COG2501	S4 domain
GWG10_RS12140	COG3385	transposase activity
GWG10_RS12145	COG1132	(ABC) transporter
GWG10_RS12155	COG1132	(ABC) transporter
GWG10_RS12165	COG3118	belongs to the thioredoxin family
GWG10_RS12170	COG0471	metal ion transport
GWG10_RS12180	COG0058	SHG alpha-glucan phosphorylase activity
GWG10_RS12210	COG0814	amino acid
GWG10_RS12215	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GWG10_RS12220	COG0514	ATP-dependent DNA helicase (RecQ)
GWG10_RS12225	COG2766	serine protein kinase
GWG10_RS12230	COG2718	Belongs to the UPF0229 family
GWG10_RS12235	COG2719	SpoVR family
GWG10_RS12240	COG2186	Transcriptional regulator
GWG10_RS12245	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GWG10_RS12250	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GWG10_RS12255	COG0586	Pfam SNARE associated Golgi protein
GWG10_RS12265	COG0556	nucleotide-excision repair
GWG10_RS12275	COG0569	domain protein
GWG10_RS12275	COG2985	domain, Protein
GWG10_RS12280	COG1196	nuclear chromosome segregation
GWG10_RS12280	COG0741	lytic transglycosylase activity
GWG10_RS12280	COG0739	heme binding
GWG10_RS12285	COG3181	Tripartite tricarboxylate transporter family receptor
GWG10_RS12300	COG4565	transcriptional regulatory protein
GWG10_RS12305	COG3290	protein histidine kinase activity
GWG10_RS12310	COG1846	Transcriptional regulator
GWG10_RS12310	COG1940	carbohydrate kinase activity
GWG10_RS12315	COG0840	transmembrane signaling receptor activity
GWG10_RS12320	COG3012	SEC-C Motif Domain Protein
GWG10_RS12325	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GWG10_RS12330	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GWG10_RS12340	COG0247	lactate metabolic process
GWG10_RS12355	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GWG10_RS12360	COG0437	4 iron, 4 sulfur cluster binding
GWG10_RS12365	COG3301	Polysulphide reductase, NrfD
GWG10_RS12375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWG10_RS12380	COG3088	subunit of a heme lyase
GWG10_RS12380	COG4235	cytochrome complex assembly
GWG10_RS12395	COG3046	protein related to deoxyribodipyrimidine photolyase
GWG10_RS12400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWG10_RS12415	COG0617	tRNA 3'-terminal CCA addition
GWG10_RS12415	COG0517	IMP dehydrogenase activity
GWG10_RS12415	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GWG10_RS12425	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GWG10_RS12430	COG0583	DNA-binding transcription factor activity
GWG10_RS12440	COG4774	siderophore transport
GWG10_RS12445	COG3706	GGDEF domain
GWG10_RS12450	COG2200	EAL domain
GWG10_RS12455	COG4977	sequence-specific DNA binding
GWG10_RS12455	COG1917	Cupin 2, conserved barrel domain protein
GWG10_RS12460	COG0583	DNA-binding transcription factor activity
GWG10_RS12465	COG2910	NAD(P)H-binding
GWG10_RS12475	COG0626	cystathionine gamma-synthase activity
GWG10_RS12480	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GWG10_RS12525	COG3039	Transposase
GWG10_RS12535	COG3250	beta-galactosidase activity
GWG10_RS12550	COG2223	nitrite transmembrane transporter activity
GWG10_RS12570	COG1609	Transcriptional regulator
GWG10_RS12575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWG10_RS12580	COG1085	galactose-1-phosphate uridylyltransferase
GWG10_RS12585	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWG10_RS12590	COG0469	pyruvate kinase activity
GWG10_RS12665	COG0210	DNA helicase
GWG10_RS12670	COG1111	helicase
GWG10_RS12670	COG1205	dead DEAH box helicase
GWG10_RS12680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWG10_RS12690	COG3039	Transposase
GWG10_RS12775	COG3550	peptidyl-serine autophosphorylation
GWG10_RS12785	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GWG10_RS12800	COG2723	6-phospho-beta-galactosidase activity
GWG10_RS12815	COG1737	Transcriptional regulator
GWG10_RS12835	COG1435	thymidine kinase activity
GWG10_RS12840	COG1757	Na H antiporter
GWG10_RS12845	COG2916	Histone family protein nucleoid-structuring protein H-NS
GWG10_RS12850	COG2096	Adenosyltransferase
GWG10_RS12855	COG3530	Putative quorum-sensing-regulated virulence factor
GWG10_RS12860	COG0602	queuosine metabolic process
GWG10_RS12865	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GWG10_RS12885	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GWG10_RS12895	COG0776	regulation of translation
GWG10_RS12900	COG0539	negative regulation of cytoplasmic translation
GWG10_RS12905	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GWG10_RS12910	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWG10_RS12940	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GWG10_RS12945	COG3300	MHYT domain
GWG10_RS12945	COG5001	Diguanylate cyclase
GWG10_RS12955	COG0583	DNA-binding transcription factor activity
GWG10_RS12960	COG0745	RESPONSE REGULATOR receiver
GWG10_RS12985	COG4989	oxidoreductase activity
GWG10_RS12990	COG0724	RNA recognition motif
GWG10_RS13000	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
GWG10_RS13010	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GWG10_RS13030	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWG10_RS13035	COG1360	Flagellar Motor Protein
GWG10_RS13040	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWG10_RS13045	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWG10_RS13050	COG0649	NAD binding
GWG10_RS13050	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWG10_RS13065	COG1034	ATP synthesis coupled electron transport
GWG10_RS13070	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GWG10_RS13075	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWG10_RS13080	COG0839	Belongs to the complex I subunit 6 family
GWG10_RS13085	COG0713	ATP synthesis coupled electron transport
GWG10_RS13095	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWG10_RS13100	COG1007	ATP synthesis coupled electron transport
GWG10_RS13105	COG0047	phosphoribosylformylglycinamidine synthase activity
GWG10_RS13105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GWG10_RS13110	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GWG10_RS13120	COG1645	bacterial-type flagellum-dependent swarming motility
GWG10_RS13125	COG1160	GTP binding
GWG10_RS13130	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWG10_RS13135	COG2976	Protein conserved in bacteria
GWG10_RS13140	COG0124	histidyl-tRNA synthetase
GWG10_RS13150	COG1426	Protein conserved in bacteria
GWG10_RS13160	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GWG10_RS13165	COG0105	UTP biosynthetic process
GWG10_RS13170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GWG10_RS13180	COG0633	Ferredoxin
GWG10_RS13185	COG0443	Heat shock 70 kDa protein
GWG10_RS13190	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GWG10_RS13200	COG0822	iron-sulfur transferase activity
GWG10_RS13205	COG1104	cysteine desulfurase activity
GWG10_RS13220	COG3154	lipid carrier protein
GWG10_RS13225	COG0826	peptidase U32
GWG10_RS13230	COG0826	peptidase U32
GWG10_RS13240	COG2897	thiosulfate sulfurtransferase activity
GWG10_RS13245	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWG10_RS13250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWG10_RS13255	COG1862	Preprotein translocase
GWG10_RS13260	COG0343	queuine tRNA-ribosyltransferase activity
GWG10_RS13265	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GWG10_RS13270	COG0517	IMP dehydrogenase activity
GWG10_RS13275	COG0450	alkyl hydroperoxide reductase
GWG10_RS13280	COG3634	alkyl hydroperoxide reductase activity
GWG10_RS13305	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWG10_RS13305	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWG10_RS13310	COG0509	glycine decarboxylation via glycine cleavage system
GWG10_RS13315	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GWG10_RS13320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWG10_RS13325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWG10_RS13345	COG2814	Major facilitator Superfamily
GWG10_RS13350	COG0444	Belongs to the ABC transporter superfamily
GWG10_RS13355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWG10_RS13360	COG0601	transmembrane transport
GWG10_RS13370	COG0625	glutathione transferase activity
GWG10_RS13375	COG0625	glutathione transferase activity
GWG10_RS13385	COG0483	inositol monophosphate 1-phosphatase activity
GWG10_RS13400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWG10_RS13405	COG2056	Na+-H+ antiporter family
GWG10_RS13410	COG2814	Major facilitator Superfamily
GWG10_RS13415	COG0583	DNA-binding transcription factor activity
GWG10_RS13420	COG5001	Diguanylate cyclase
GWG10_RS13435	COG2050	protein possibly involved in aromatic compounds catabolism
GWG10_RS13445	COG0247	lactate metabolic process
GWG10_RS13445	COG0277	FAD linked oxidase domain protein
GWG10_RS13460	COG1253	flavin adenine dinucleotide binding
GWG10_RS13465	COG1902	pentaerythritol trinitrate reductase activity
GWG10_RS13475	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GWG10_RS13480	COG0647	UMP catabolic process
GWG10_RS13490	COG0367	asparagine synthase
GWG10_RS13505	COG0625	glutathione transferase activity
GWG10_RS13515	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GWG10_RS13530	COG0564	pseudouridine synthase activity
GWG10_RS13535	COG5001	Diguanylate cyclase
GWG10_RS13545	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GWG10_RS13580	COG0670	Belongs to the BI1 family
GWG10_RS13585	COG1289	transmembrane transporter activity
GWG10_RS13590	COG2920	part of a sulfur-relay system
GWG10_RS13595	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GWG10_RS13600	COG0285	dihydrofolate synthase activity
GWG10_RS13605	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GWG10_RS13610	COG0101	tRNA pseudouridine synthase activity
GWG10_RS13620	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GWG10_RS13625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWG10_RS13635	COG1464	Belongs to the NlpA lipoprotein family
GWG10_RS13655	COG1119	ATPase activity
GWG10_RS13660	COG0574	Belongs to the PEP-utilizing enzyme family
GWG10_RS13660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWG10_RS13665	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GWG10_RS13675	COG1113	amino acid transport
GWG10_RS13720	COG1242	4 iron, 4 sulfur cluster binding
GWG10_RS13725	COG0070	glutamate synthase
GWG10_RS13725	COG0069	glutamate synthase activity
GWG10_RS13725	COG0067	glutamate synthase
GWG10_RS13730	COG0493	'glutamate synthase
GWG10_RS13745	COG4104	PAAR repeat-containing protein
GWG10_RS13755	COG0513	Belongs to the DEAD box helicase family
GWG10_RS13785	COG3706	GGDEF domain
GWG10_RS13790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWG10_RS13795	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GWG10_RS13800	COG0505	Belongs to the CarA family
GWG10_RS13805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GWG10_RS13815	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GWG10_RS13820	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GWG10_RS13825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWG10_RS13830	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GWG10_RS13835	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWG10_RS13840	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GWG10_RS13845	COG4139	cobalamin transport
GWG10_RS13870	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GWG10_RS13880	COG0023	Translation Initiation Factor
GWG10_RS13885	COG2119	membrane
GWG10_RS13920	COG2203	Gaf domain
GWG10_RS13920	COG2199	diguanylate cyclase activity
GWG10_RS13925	COG0556	nucleotide-excision repair
GWG10_RS13950	COG0215	cysteine-tRNA ligase activity
GWG10_RS13955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GWG10_RS13965	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWG10_RS13970	COG2261	transglycosylase associated protein
GWG10_RS13975	COG1309	transcriptional regulator
GWG10_RS13980	COG0604	alcohol dehydrogenase
GWG10_RS14010	COG0322	excinuclease ABC activity
GWG10_RS14015	COG2197	response regulator
GWG10_RS14020	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GWG10_RS14025	COG2835	tetraacyldisaccharide 4'-kinase activity
GWG10_RS14030	COG1663	tetraacyldisaccharide 4'-kinase activity
GWG10_RS14035	COG1132	(ABC) transporter
GWG10_RS14040	COG0658	competence protein
GWG10_RS14040	COG2333	competence protein COMEC
GWG10_RS14055	COG0433	COG0433 Predicted ATPase
GWG10_RS14060	COG1448	Aminotransferase
GWG10_RS14075	COG1199	ATP-dependent helicase activity
GWG10_RS14090	COG0123	including yeast histone deacetylase and acetoin utilization protein
GWG10_RS14095	COG0477	Major facilitator Superfamily
GWG10_RS14100	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GWG10_RS14105	COG1785	Belongs to the alkaline phosphatase family
GWG10_RS14125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWG10_RS14130	COG3706	GGDEF domain
GWG10_RS14135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG10_RS14140	COG0765	amino acid transport
GWG10_RS14145	COG1126	abc transporter atp-binding protein
GWG10_RS14155	COG0531	amino acid
GWG10_RS14170	COG1253	flavin adenine dinucleotide binding
GWG10_RS14175	COG0704	Plays a role in the regulation of phosphate uptake
GWG10_RS14185	COG0581	inorganic phosphate transmembrane transporter activity
GWG10_RS14190	COG0573	inorganic phosphate transmembrane transporter activity
GWG10_RS14195	COG0590	tRNA wobble adenosine to inosine editing
GWG10_RS14210	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GWG10_RS14230	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GWG10_RS14235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GWG10_RS14240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GWG10_RS14245	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GWG10_RS14255	COG3852	Histidine kinase
GWG10_RS14270	COG2716	regulation of RNA biosynthetic process
GWG10_RS14275	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GWG10_RS14285	COG2239	Acts as a magnesium transporter
GWG10_RS14300	COG1705	Flagellar rod assembly protein muramidase FlgJ
GWG10_RS14300	COG3951	Flagellar rod assembly protein muramidase FlgJ
GWG10_RS14305	COG1706	bacterial-type flagellum-dependent cell motility
GWG10_RS14310	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GWG10_RS14325	COG1749	Flagellar hook protein flgE
GWG10_RS14340	COG1815	bacterial-type flagellum-dependent cell motility
GWG10_RS14345	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GWG10_RS14350	COG0784	Response regulator, receiver
GWG10_RS14350	COG0835	chemotaxis
GWG10_RS14355	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
GWG10_RS14370	COG0622	Phosphoesterase
GWG10_RS14375	COG4166	transmembrane transport
GWG10_RS14390	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GWG10_RS14395	COG0675	Transposase, IS605 OrfB family
GWG10_RS14405	COG0697	spore germination
GWG10_RS14410	COG4166	transmembrane transport
GWG10_RS14435	COG1278	Cold shock
GWG10_RS14475	COG0675	Transposase, IS605 OrfB family
GWG10_RS14485	COG3132	Protein of unknown function, DUF480
GWG10_RS14505	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWG10_RS14525	COG0489	protein tyrosine kinase activity
GWG10_RS14525	COG3206	protein involved in exopolysaccharide biosynthesis
GWG10_RS14530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWG10_RS14570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWG10_RS14620	COG1091	dTDP-4-dehydrorhamnose reductase activity
GWG10_RS14630	COG0745	RESPONSE REGULATOR receiver
GWG10_RS14645	COG1737	Transcriptional regulator
GWG10_RS14650	COG0469	pyruvate kinase activity
GWG10_RS14660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWG10_RS14665	COG1960	acyl-CoA dehydrogenase activity
GWG10_RS14675	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GWG10_RS14695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWG10_RS14700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG10_RS14705	COG1309	transcriptional regulator
GWG10_RS14720	COG1946	Acyl-CoA thioesterase
GWG10_RS14735	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GWG10_RS14745	COG0009	L-threonylcarbamoyladenylate synthase
GWG10_RS14750	COG0613	PHP domain protein
GWG10_RS14755	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GWG10_RS14760	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWG10_RS14760	COG0512	Glutamine amidotransferase of anthranilate synthase
GWG10_RS14765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWG10_RS14770	COG0134	indole-3-glycerol-phosphate synthase activity
GWG10_RS14770	COG0135	phosphoribosylanthranilate isomerase activity
GWG10_RS14775	COG0133	tryptophan synthase activity
GWG10_RS14780	COG0159	tryptophan synthase activity
GWG10_RS14815	COG1988	membrane-bound metal-dependent
GWG10_RS14820	COG1396	sequence-specific DNA binding
GWG10_RS14825	COG3550	peptidyl-serine autophosphorylation
GWG10_RS14845	COG0583	DNA-binding transcription factor activity
GWG10_RS14855	COG5507	3-demethylubiquinone-9 3-methyltransferase
GWG10_RS14860	COG2814	Major facilitator Superfamily
GWG10_RS14870	COG0109	protoheme IX farnesyltransferase activity
GWG10_RS14875	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GWG10_RS14880	COG1845	cytochrome c oxidase, subunit III
GWG10_RS14885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWG10_RS14890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWG10_RS14895	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWG10_RS14900	COG0583	DNA-binding transcription factor activity
GWG10_RS14920	COG1846	Transcriptional regulator
GWG10_RS14935	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GWG10_RS14950	COG0745	RESPONSE REGULATOR receiver
GWG10_RS14960	COG0708	Exodeoxyribonuclease III
GWG10_RS14970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG10_RS14975	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWG10_RS14990	COG0095	Lipoate-protein ligase
GWG10_RS15020	COG0640	Transcriptional regulator
GWG10_RS15030	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWG10_RS15040	COG1285	pathogenesis
GWG10_RS15070	COG0484	heat shock protein binding
GWG10_RS15075	COG0443	Heat shock 70 kDa protein
GWG10_RS15080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GWG10_RS15085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GWG10_RS15090	COG3706	GGDEF domain
GWG10_RS15095	COG0497	DNA recombination
GWG10_RS15105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG10_RS15110	COG1136	(ABC) transporter
GWG10_RS15110	COG0577	efflux transmembrane transporter activity
GWG10_RS15120	COG2375	cellular response to nickel ion
GWG10_RS15125	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWG10_RS15130	COG2916	Histone family protein nucleoid-structuring protein H-NS
GWG10_RS15135	COG0583	DNA-binding transcription factor activity
GWG10_RS15140	COG3048	D-serine ammonia-lyase activity
GWG10_RS15150	COG0538	isocitrate dehydrogenase activity
GWG10_RS15185	COG0456	acetyltransferase
GWG10_RS15190	COG1187	pseudouridine synthase activity
GWG10_RS15200	COG0482	sulfurtransferase activity
GWG10_RS15205	COG2915	High frequency lysogenization protein hflD homolog
GWG10_RS15210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GWG10_RS15215	COG2850	peptidyl-arginine hydroxylation
GWG10_RS15225	COG1196	nuclear chromosome segregation
GWG10_RS15225	COG3264	Mechanosensitive ion channel
GWG10_RS15255	COG0281	malic enzyme
GWG10_RS15260	COG0746	molybdenum cofactor guanylyltransferase activity
GWG10_RS15265	COG1763	Mo-molybdopterin cofactor biosynthetic process
GWG10_RS15270	COG1289	transmembrane transporter activity
GWG10_RS15275	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GWG10_RS15305	COG3220	belongs to the UPF0276 family
GWG10_RS15315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWG10_RS15345	COG4319	ketosteroid isomerase
GWG10_RS15350	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWG10_RS15355	COG0083	homoserine kinase activity
GWG10_RS15365	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GWG10_RS15370	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GWG10_RS15385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GWG10_RS15395	COG0745	RESPONSE REGULATOR receiver
GWG10_RS15410	COG4988	ABC transporter
GWG10_RS15415	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GWG10_RS15435	COG1720	tRNA m6t6A37 methyltransferase activity
GWG10_RS15450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWG10_RS15455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GWG10_RS15465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWG10_RS15475	COG2190	(PTS) system
GWG10_RS15480	COG3038	cytochrome b561
GWG10_RS15490	COG0420	3'-5' exonuclease activity
GWG10_RS15495	COG1247	-acetyltransferase
GWG10_RS15500	COG2974	May be involved in recombination
GWG10_RS15515	COG5433	transposase activity
GWG10_RS15525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GWG10_RS15525	COG4651	solute:proton antiporter activity
GWG10_RS15560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWG10_RS15565	COG1917	Cupin 2, conserved barrel domain protein
GWG10_RS15565	COG1396	sequence-specific DNA binding
GWG10_RS15570	COG1012	belongs to the aldehyde dehydrogenase family
GWG10_RS15585	COG0531	amino acid
GWG10_RS15590	COG0531	amino acid
GWG10_RS15600	COG1283	sodium-dependent phosphate transmembrane transporter activity
GWG10_RS15610	COG3384	dioxygenase
GWG10_RS15615	COG2205	protein histidine kinase activity
GWG10_RS15615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG10_RS15640	COG0784	Response regulator, receiver
GWG10_RS15640	COG2205	protein histidine kinase activity
GWG10_RS15650	COG1376	ErfK ybiS ycfS ynhG family protein
GWG10_RS15650	COG1388	LysM domain
GWG10_RS15665	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GWG10_RS15670	COG0791	NLP P60 protein
GWG10_RS15685	COG3118	belongs to the thioredoxin family
GWG10_RS15695	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWG10_RS15700	COG0788	formyltetrahydrofolate deformylase activity
GWG10_RS15725	COG0739	heme binding
GWG10_RS15725	COG0741	lytic transglycosylase activity
GWG10_RS15725	COG1196	nuclear chromosome segregation
GWG10_RS15735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GWG10_RS15740	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GWG10_RS15745	COG0673	inositol 2-dehydrogenase activity
GWG10_RS15775	COG1032	radical SAM domain protein
GWG10_RS15780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWG10_RS15790	COG3706	GGDEF domain
GWG10_RS15795	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWG10_RS15800	COG0733	neurotransmitter:sodium symporter activity
GWG10_RS15830	COG0281	malic enzyme
GWG10_RS15835	COG2207	Transcriptional regulator
GWG10_RS15855	COG2233	PERMEase
GWG10_RS15860	COG0095	Lipoate-protein ligase
GWG10_RS15865	COG1115	amino acid carrier protein
GWG10_RS15870	COG0019	diaminopimelate decarboxylase activity
GWG10_RS15880	COG0678	peroxiredoxin activity
GWG10_RS15885	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GWG10_RS15895	COG1126	abc transporter atp-binding protein
GWG10_RS15900	COG0765	amino acid transport
GWG10_RS15905	COG4597	amino acid ABC transporter
GWG10_RS15910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG10_RS15925	COG1131	(ABC) transporter
GWG10_RS15930	COG0545	Peptidyl-prolyl cis-trans isomerase
GWG10_RS15950	COG3142	Participates in the control of copper homeostasis
GWG10_RS15955	COG1940	carbohydrate kinase activity
GWG10_RS15965	COG4783	chaperone-mediated protein folding
GWG10_RS15975	COG5002	protein histidine kinase activity
GWG10_RS15980	COG0745	RESPONSE REGULATOR receiver
GWG10_RS15985	COG0346	lactoylglutathione lyase activity
GWG10_RS15990	COG3706	GGDEF domain
GWG10_RS15995	COG3284	Transcriptional regulator
GWG10_RS16000	COG1012	belongs to the aldehyde dehydrogenase family
GWG10_RS16010	COG0697	spore germination
GWG10_RS16020	COG0667	Aldo Keto reductase
GWG10_RS16035	COG3290	protein histidine kinase activity
GWG10_RS16045	COG1566	PFAM secretion protein HlyD family protein
GWG10_RS16070	COG0602	queuosine metabolic process
GWG10_RS16075	COG1328	CTP reductase activity
GWG10_RS16085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GWG10_RS16090	COG3115	cell septum assembly
GWG10_RS16095	COG1196	nuclear chromosome segregation
GWG10_RS16105	COG2860	membrane
GWG10_RS16115	COG3108	Peptidase M15
GWG10_RS16120	COG2989	Protein conserved in bacteria
GWG10_RS16135	COG0463	Glycosyl transferase, family 2
GWG10_RS16185	COG3706	GGDEF domain
GWG10_RS16190	COG0037	tRNA processing
GWG10_RS16205	COG0488	(ABC) transporter
GWG10_RS16215	COG0531	amino acid
GWG10_RS16220	COG0814	amino acid
GWG10_RS16235	COG0825	malonyl-CoA metabolic process
GWG10_RS16240	COG0587	DNA-directed DNA polymerase activity
GWG10_RS16245	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GWG10_RS16250	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWG10_RS16255	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWG10_RS16260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWG10_RS16265	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWG10_RS16280	COG0750	zinc metalloprotease
GWG10_RS16285	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GWG10_RS16290	COG0575	Belongs to the CDS family
GWG10_RS16295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GWG10_RS16300	COG0233	cytoplasmic translational termination
GWG10_RS16305	COG0528	UMP kinase activity
GWG10_RS16310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GWG10_RS16315	COG0052	Belongs to the universal ribosomal protein uS2 family
GWG10_RS16320	COG0024	Methionine aminopeptidase
GWG10_RS16325	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GWG10_RS16330	COG2171	N-acyltransferase activity
GWG10_RS16340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWG10_RS16340	COG1263	PTS System
GWG10_RS16365	COG0564	pseudouridine synthase activity
GWG10_RS16370	COG3098	single-species biofilm formation
GWG10_RS16395	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GWG10_RS16405	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GWG10_RS16405	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GWG10_RS16415	COG3706	GGDEF domain
GWG10_RS16420	COG1611	Belongs to the LOG family
GWG10_RS16425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWG10_RS16430	COG0473	3-isopropylmalate dehydrogenase activity
GWG10_RS16440	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GWG10_RS16455	COG0583	DNA-binding transcription factor activity
GWG10_RS16460	COG0840	transmembrane signaling receptor activity
GWG10_RS16465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWG10_RS16480	COG1477	protein flavinylation
GWG10_RS16485	COG2871	sodium ion transport
GWG10_RS16490	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWG10_RS16495	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWG10_RS16500	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWG10_RS16505	COG1805	sodium ion transport
GWG10_RS16510	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWG10_RS16515	COG0271	Belongs to the BolA IbaG family
GWG10_RS16520	COG2813	Specifically methylates the guanine in position
GWG10_RS16530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GWG10_RS16540	COG2211	Major facilitator Superfamily
GWG10_RS16545	COG3248	Nucleoside-binding outer membrane protein
GWG10_RS16550	COG1666	GTP binding
GWG10_RS16565	COG0659	secondary active sulfate transmembrane transporter activity
GWG10_RS16575	COG0745	RESPONSE REGULATOR receiver
GWG10_RS16580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG10_RS16585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWG10_RS16595	COG0582	viral genome integration into host DNA
GWG10_RS16605	COG2916	Histone family protein nucleoid-structuring protein H-NS
GWG10_RS16615	COG4983	Phage plasmid primase, P4 family domain protein
GWG10_RS16635	COG5377	YqaJ viral recombinase family
GWG10_RS16665	COG2003	Belongs to the UPF0758 family
GWG10_RS16715	COG0583	DNA-binding transcription factor activity
GWG10_RS16720	COG0549	Belongs to the carbamate kinase family
GWG10_RS16725	COG1304	FMN binding
GWG10_RS16730	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GWG10_RS16775	COG2003	Belongs to the UPF0758 family
GWG10_RS16800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWG10_RS16825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWG10_RS16835	COG3318	Belongs to the UPF0149 family
GWG10_RS16835	COG3012	SEC-C Motif Domain Protein
GWG10_RS16850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWG10_RS16860	COG1151	hydroxylamine reductase activity
GWG10_RS16865	COG0783	Belongs to the Dps family
GWG10_RS16890	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GWG10_RS16905	COG4221	oxidoreductase activity
GWG10_RS16915	COG0415	Belongs to the DNA photolyase family
GWG10_RS16920	COG0789	Transcriptional regulator
GWG10_RS16925	COG3272	Protein of unknown function (DUF1722)
GWG10_RS16950	COG1605	Chorismate mutase
GWG10_RS16950	COG0077	Prephenate dehydratase
GWG10_RS17025	COG2801	Transposase and inactivated derivatives
GWG10_RS17035	COG2203	Gaf domain
GWG10_RS17035	COG2199	diguanylate cyclase activity
GWG10_RS17055	COG5642	Protein of unknown function (DUF2384)
GWG10_RS17075	COG3328	transposase activity
GWG10_RS17090	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GWG10_RS17115	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GWG10_RS17160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWG10_RS17165	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWG10_RS17230	COG4584	PFAM Integrase catalytic
GWG10_RS17255	COG2916	Histone family protein nucleoid-structuring protein H-NS
GWG10_RS17260	COG3039	Transposase
GWG10_RS17305	COG1484	DNA-dependent DNA replication
GWG10_RS17310	COG4584	PFAM Integrase catalytic
GWG10_RS17325	COG2133	pyrroloquinoline quinone binding
GWG10_RS17335	COG1349	DNA-binding transcription factor activity
GWG10_RS17340	COG2084	Dehydrogenase
GWG10_RS17345	COG3395	kinase activity
GWG10_RS17350	COG0235	Class ii aldolase
GWG10_RS17355	COG3622	Belongs to the hyi family
GWG10_RS17360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWG10_RS17365	COG2610	gluconate transmembrane transporter activity
GWG10_RS17385	COG0300	oxidoreductase activity
GWG10_RS17410	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GWG10_RS17430	COG3813	Protein conserved in bacteria
GWG10_RS17440	COG0826	peptidase U32
GWG10_RS17445	COG1280	lysine exporter protein (LysE YggA)
GWG10_RS17480	COG2199	diguanylate cyclase activity
GWG10_RS17480	COG2203	Gaf domain
GWG10_RS17480	COG2200	EAL domain
GWG10_RS17525	COG1566	PFAM secretion protein HlyD family protein
GWG10_RS17535	COG0114	fumarate hydratase activity
GWG10_RS17545	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GWG10_RS17545	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GWG10_RS17545	COG0506	proline dehydrogenase activity
GWG10_RS17550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWG10_RS17565	COG0737	Belongs to the 5'-nucleotidase family
GWG10_RS17585	COG2204	response regulator
GWG10_RS17590	COG0545	Peptidyl-prolyl cis-trans isomerase
GWG10_RS17600	COG2900	Belongs to the SlyX family
GWG10_RS17605	COG1047	Peptidyl-prolyl cis-trans
GWG10_RS17610	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GWG10_RS17620	COG0784	Response regulator, receiver
GWG10_RS17620	COG0835	chemotaxis
GWG10_RS17625	COG0429	hydrolase of the alpha beta-hydrolase fold
GWG10_RS17630	COG4251	negative regulation of phosphorylation
GWG10_RS17630	COG5001	Diguanylate cyclase
GWG10_RS17630	COG3706	GGDEF domain
GWG10_RS17630	COG2203	Gaf domain
GWG10_RS17635	COG3089	Belongs to the UPF0270 family
GWG10_RS17640	COG3954	Phosphoribulokinase
GWG10_RS17655	COG1765	OsmC-like protein
GWG10_RS17665	COG2226	methyltransferase
GWG10_RS17675	COG2205	protein histidine kinase activity
GWG10_RS17675	COG2202	Pas domain
GWG10_RS17680	COG2814	Major facilitator Superfamily
GWG10_RS17705	COG0748	coenzyme F420 binding
GWG10_RS17710	COG3721	Heme iron utilization protein
GWG10_RS17720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWG10_RS17745	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GWG10_RS17755	COG0463	Glycosyl transferase, family 2
GWG10_RS17760	COG0741	lytic transglycosylase activity
GWG10_RS17845	COG0616	signal peptide processing
GWG10_RS17860	COG1802	Transcriptional regulator
GWG10_RS17860	COG4626	Terminase
GWG10_RS17925	COG3328	transposase activity
GWG10_RS17935	COG4968	Prepilin-type N-terminal cleavage methylation domain
GWG10_RS17940	COG2135	peptidase activity
GWG10_RS17945	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWG10_RS17950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWG10_RS17970	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GWG10_RS18045	COG1846	Transcriptional regulator
GWG10_RS18105	COG0582	viral genome integration into host DNA
GWG10_RS18110	COG0488	(ABC) transporter
GWG10_RS18120	COG2252	PERMEase
GWG10_RS18125	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GWG10_RS18130	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GWG10_RS18135	COG3178	'Phosphotransferase
GWG10_RS18140	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GWG10_RS18155	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GWG10_RS18160	COG2967	ApaG domain
GWG10_RS18165	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWG10_RS18175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWG10_RS18180	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GWG10_RS18190	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GWG10_RS18195	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GWG10_RS18200	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GWG10_RS18205	COG0142	geranyltranstransferase activity
GWG10_RS18210	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GWG10_RS18215	COG0330	HflC and HflK could
GWG10_RS18220	COG0330	HflC and HflK could
GWG10_RS18225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GWG10_RS18230	COG1923	regulation of RNA biosynthetic process
GWG10_RS18235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GWG10_RS18240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWG10_RS18250	COG0802	atpase or kinase
GWG10_RS18255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GWG10_RS18255	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GWG10_RS18275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWG10_RS18280	COG2011	ABC-type metal ion transport system permease component
GWG10_RS18285	COG1464	Belongs to the NlpA lipoprotein family
GWG10_RS18305	COG2205	protein histidine kinase activity
GWG10_RS18305	COG0784	Response regulator, receiver
GWG10_RS18320	COG2198	Histidine kinase
GWG10_RS18320	COG0784	Response regulator, receiver
GWG10_RS18320	COG5002	protein histidine kinase activity
GWG10_RS18340	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GWG10_RS18355	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GWG10_RS18360	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GWG10_RS18365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWG10_RS18370	COG2716	regulation of RNA biosynthetic process
GWG10_RS18375	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWG10_RS18380	COG3013	Belongs to the UPF0304 family
GWG10_RS18390	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GWG10_RS18395	COG0857	belongs to the CobB CobQ family
GWG10_RS18395	COG0280	phosphate acetyltransferase
GWG10_RS18400	COG0440	acetolactate synthase activity
GWG10_RS18405	COG0028	Belongs to the TPP enzyme family
GWG10_RS18420	COG0671	phosphoesterase, PA-phosphatase related
GWG10_RS18430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWG10_RS18435	COG0473	3-isopropylmalate dehydrogenase activity
GWG10_RS18440	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GWG10_RS18445	COG0066	3-isopropylmalate dehydratase activity
GWG10_RS18460	COG4143	(ABC) transporter
GWG10_RS18465	COG1178	ABC-type Fe3 transport system permease component
GWG10_RS18470	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GWG10_RS18480	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GWG10_RS18490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWG10_RS18525	COG0316	Belongs to the HesB IscA family
GWG10_RS18535	COG0038	chloride channel
GWG10_RS18540	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWG10_RS18555	COG0671	phosphoesterase, PA-phosphatase related
GWG10_RS18565	COG0583	DNA-binding transcription factor activity
GWG10_RS18570	COG2076	Multidrug Resistance protein
GWG10_RS18580	COG0346	lactoylglutathione lyase activity
GWG10_RS18585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWG10_RS18590	COG1643	Atp-dependent helicase
GWG10_RS18600	COG1489	DNA binding
GWG10_RS18605	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GWG10_RS18610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWG10_RS18620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GWG10_RS18625	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GWG10_RS18630	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GWG10_RS18640	COG0842	Transport permease protein
GWG10_RS18645	COG1131	(ABC) transporter
GWG10_RS18660	COG0163	prenyltransferase activity
GWG10_RS18665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWG10_RS18670	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GWG10_RS18685	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GWG10_RS18700	COG1136	(ABC) transporter
GWG10_RS18760	COG2801	Transposase and inactivated derivatives
GWG10_RS18765	COG0529	Catalyzes the synthesis of activated sulfate
GWG10_RS18770	COG0471	metal ion transport
GWG10_RS18770	COG3273	potassium ion transport
GWG10_RS18775	COG2895	sulfate adenylyltransferase (ATP) activity
GWG10_RS18780	COG0175	sulfate reduction
GWG10_RS18785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWG10_RS18785	COG1648	precorrin-2 dehydrogenase activity
GWG10_RS18790	COG0330	HflC and HflK could
GWG10_RS18795	COG1585	Membrane protein implicated in regulation of membrane protease activity
GWG10_RS18805	COG0673	inositol 2-dehydrogenase activity
GWG10_RS18815	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GWG10_RS18820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWG10_RS18825	COG3036	rescue of stalled ribosome
GWG10_RS18840	COG0138	bifunctional purine biosynthesis protein purh
GWG10_RS18875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GWG10_RS18880	COG0358	DNA primase activity
GWG10_RS18885	COG1610	YqeY-like protein
GWG10_RS18890	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GWG10_RS18895	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GWG10_RS18905	COG4942	peptidase
GWG10_RS18905	COG1388	LysM domain
GWG10_RS18910	COG1238	metal cluster binding
GWG10_RS18915	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GWG10_RS18920	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GWG10_RS18925	COG0585	pseudouridine synthase activity
GWG10_RS18935	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GWG10_RS18940	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GWG10_RS18945	COG0148	phosphopyruvate hydratase activity
GWG10_RS18950	COG0504	CTP synthase activity
GWG10_RS18955	COG3956	TIGRFAM MazG family protein
GWG10_RS18960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWG10_RS18965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWG10_RS18975	COG4807	Protein conserved in bacteria
GWG10_RS18980	COG3023	N-Acetylmuramoyl-L-alanine amidase
GWG10_RS18985	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GWG10_RS18990	COG1381	Involved in DNA repair and RecF pathway recombination
GWG10_RS19000	COG0571	ribonuclease III activity
GWG10_RS19005	COG0681	Belongs to the peptidase S26 family
GWG10_RS19010	COG0481	GTPase activity
GWG10_RS19025	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GWG10_RS19030	COG1595	DNA-templated transcription, initiation
GWG10_RS19035	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GWG10_RS19045	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GWG10_RS19055	COG0583	DNA-binding transcription factor activity
GWG10_RS19085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWG10_RS19095	COG0126	phosphoglycerate kinase activity
GWG10_RS19100	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWG10_RS19105	COG1940	carbohydrate kinase activity
GWG10_RS19110	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GWG10_RS19115	COG2816	NAD+ diphosphatase activity
GWG10_RS19120	COG4991	sh3 domain protein
GWG10_RS19125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWG10_RS19140	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GWG10_RS19145	COG1028	Short-chain dehydrogenase reductase Sdr
GWG10_RS19155	COG1505	serine-type exopeptidase activity
GWG10_RS19160	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWG10_RS19165	COG0765	amino acid transport
GWG10_RS19170	COG0765	amino acid transport
GWG10_RS19175	COG1126	abc transporter atp-binding protein
GWG10_RS19180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWG10_RS19185	COG3174	membrane
GWG10_RS19190	COG0110	maltose O-acetyltransferase activity
GWG10_RS19220	COG1942	4-Oxalocrotonate Tautomerase
GWG10_RS19230	COG0583	DNA-binding transcription factor activity
GWG10_RS19240	COG0165	Argininosuccinate lyase
GWG10_RS19245	COG0137	argininosuccinate synthase activity
GWG10_RS19255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWG10_RS19260	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GWG10_RS19270	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GWG10_RS19275	COG5002	protein histidine kinase activity
GWG10_RS19275	COG5001	Diguanylate cyclase
GWG10_RS19275	COG3447	MASE1 domain protein
GWG10_RS19280	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GWG10_RS19315	COG0583	DNA-binding transcription factor activity
GWG10_RS19320	COG1380	Effector of murein hydrolase LrgA
GWG10_RS19325	COG1346	cytolysis
GWG10_RS19330	COG0460	homoserine dehydrogenase
GWG10_RS19330	COG0527	aspartate kinase activity
GWG10_RS19335	COG0626	cystathionine gamma-synthase activity
GWG10_RS19350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWG10_RS19355	COG0814	amino acid
GWG10_RS19360	COG1218	3'(2'),5'-bisphosphate nucleotidase
GWG10_RS19365	COG0494	nUDIX hydrolase
GWG10_RS19370	COG1011	Hydrolase
GWG10_RS19375	COG1902	pentaerythritol trinitrate reductase activity
GWG10_RS19385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWG10_RS19400	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GWG10_RS19410	COG3156	type II secretion system protein K
GWG10_RS19420	COG4795	General secretion pathway protein
GWG10_RS19425	COG2165	general secretion pathway protein
GWG10_RS19435	COG2165	general secretion pathway protein
GWG10_RS19440	COG1459	type II secretion system
GWG10_RS19445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWG10_RS19455	COG3031	protein transport across the cell outer membrane
GWG10_RS19465	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GWG10_RS19470	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GWG10_RS19490	COG3133	Outer membrane lipoprotein
GWG10_RS19495	COG3025	triphosphatase activity
GWG10_RS19500	COG1392	Phosphate transport regulator
GWG10_RS19505	COG0306	phosphate transporter
GWG10_RS19510	COG0617	tRNA 3'-terminal CCA addition
GWG10_RS19515	COG3409	Peptidoglycan-binding domain 1 protein
GWG10_RS19515	COG3267	Type II secretory pathway component ExeA
GWG10_RS19525	COG1194	a g-specific adenine glycosylase
GWG10_RS19530	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GWG10_RS19545	COG3240	lipase activity
GWG10_RS19555	COG3009	Protein conserved in bacteria
GWG10_RS19560	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GWG10_RS19560	COG3008	intermembrane lipid transfer
GWG10_RS19565	COG2995	paraquat-inducible protein a
GWG10_RS19575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWG10_RS19580	COG2203	Gaf domain
GWG10_RS19580	COG3706	GGDEF domain
GWG10_RS19580	COG4251	negative regulation of phosphorylation
GWG10_RS19580	COG5001	Diguanylate cyclase
GWG10_RS19585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWG10_RS19590	COG2813	Specifically methylates the guanine in position
GWG10_RS19595	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GWG10_RS19600	COG0297	glycogen (starch) synthase activity
GWG10_RS19635	COG1757	Na H antiporter
GWG10_RS19640	COG0583	DNA-binding transcription factor activity
GWG10_RS19645	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GWG10_RS19650	COG3842	ATPase activity
GWG10_RS19655	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWG10_RS19660	COG1177	transmembrane transport
GWG10_RS19665	COG1012	belongs to the aldehyde dehydrogenase family
GWG10_RS19670	COG0109	protoheme IX farnesyltransferase activity
GWG10_RS19700	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GWG10_RS19710	COG1565	acr, cog1565
GWG10_RS19710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWG10_RS19715	COG1444	tRNA N-acetyltransferase activity
GWG10_RS19735	COG1803	Methylglyoxal synthase
GWG10_RS19750	COG0252	asparaginase activity
GWG10_RS19770	COG1263	PTS System
GWG10_RS19770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWG10_RS19775	COG0366	Alpha amylase catalytic
GWG10_RS19780	COG0110	maltose O-acetyltransferase activity
GWG10_RS19785	COG1522	sequence-specific DNA binding
GWG10_RS19815	COG3068	Protein conserved in bacteria
GWG10_RS19825	COG0739	heme binding
GWG10_RS19845	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GWG10_RS19850	COG1121	(ABC) transporter
GWG10_RS19855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWG10_RS19860	COG0583	DNA-binding transcription factor activity
GWG10_RS19870	COG1573	uracil-dna glycosylase
GWG10_RS19875	COG2962	Rard protein
GWG10_RS19880	COG2827	Endonuclease containing a URI domain
GWG10_RS19895	COG1842	Phage shock protein A
GWG10_RS19900	COG0204	Acyl-transferase
GWG10_RS19920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWG10_RS19930	COG0484	heat shock protein binding
GWG10_RS19985	COG1289	transmembrane transporter activity
GWG10_RS19990	COG1566	PFAM secretion protein HlyD family protein
GWG10_RS20005	COG1051	belongs to the nudix hydrolase family
GWG10_RS20010	COG3150	esterase
GWG10_RS20020	COG3151	Protein conserved in bacteria
GWG10_RS20025	COG0494	nUDIX hydrolase
GWG10_RS20030	COG1538	Outer membrane efflux protein
GWG10_RS20035	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GWG10_RS20035	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GWG10_RS20040	COG1560	Kdo2-lipid A biosynthetic process
GWG10_RS20055	COG2771	luxR family
GWG10_RS20060	COG3916	Acyl-homoserine-lactone synthase
GWG10_RS20070	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GWG10_RS20075	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWG10_RS20075	COG2213	PTS system mannitol-specific
GWG10_RS20080	COG0246	Mannitol dehydrogenase
GWG10_RS20085	COG3722	fumarate hydratase activity
GWG10_RS20090	COG3263	regulation of cellular component size
GWG10_RS20110	COG1671	Belongs to the UPF0178 family
GWG10_RS20125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWG10_RS20130	COG5433	transposase activity
GWG10_RS20135	COG0513	Belongs to the DEAD box helicase family
GWG10_RS20155	COG1575	Belongs to the MenA family. Type 1 subfamily
GWG10_RS20160	COG1169	isochorismate synthase
GWG10_RS20165	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GWG10_RS20170	COG0596	Alpha beta hydrolase
GWG10_RS20175	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GWG10_RS20185	COG0318	PFAM AMP-dependent synthetase and ligase
GWG10_RS20190	COG3291	Pkd domain containing protein
GWG10_RS20195	COG2949	membrane
GWG10_RS20200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GWG10_RS20210	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GWG10_RS20240	COG2873	o-acetylhomoserine
GWG10_RS20250	COG1979	alcohol dehydrogenase
GWG10_RS20265	COG4221	oxidoreductase activity
GWG10_RS20285	COG1285	pathogenesis
GWG10_RS20300	COG1368	sulfuric ester hydrolase activity
GWG10_RS20305	COG1522	sequence-specific DNA binding
GWG10_RS20315	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GWG10_RS20325	COG1546	Belongs to the CinA family
GWG10_RS20325	COG1058	Belongs to the CinA family
GWG10_RS20330	COG1988	membrane-bound metal-dependent
GWG10_RS20340	COG0561	phosphatase activity
GWG10_RS20345	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GWG10_RS20355	COG1011	Hydrolase
GWG10_RS20370	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GWG10_RS20375	COG0019	diaminopimelate decarboxylase activity
GWG10_RS20385	COG1965	Belongs to the frataxin family
GWG10_RS20390	COG0400	carboxylic ester hydrolase activity
GWG10_RS20395	COG3072	Adenylate cyclase
GWG10_RS20400	COG0181	hydroxymethylbilane synthase activity
GWG10_RS20410	COG2959	enzyme of heme biosynthesis
GWG10_RS20415	COG3071	HemY protein
GWG10_RS20435	COG3028	Belongs to the UPF0307 family
GWG10_RS20445	COG2926	Belongs to the UPF0265 family
GWG10_RS20480	COG1396	sequence-specific DNA binding
GWG10_RS20485	COG3135	benzoate transporter
GWG10_RS20515	COG3047	cAMP biosynthetic process
GWG10_RS20520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWG10_RS20525	COG2197	response regulator
GWG10_RS20535	COG4974	Belongs to the 'phage' integrase family
GWG10_RS20565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWG10_RS20620	COG0745	RESPONSE REGULATOR receiver
GWG10_RS20625	COG5002	protein histidine kinase activity
GWG10_RS20685	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GWG10_RS20690	COG1304	FMN binding
GWG10_RS20695	COG0549	Belongs to the carbamate kinase family
GWG10_RS20700	COG0583	DNA-binding transcription factor activity
GWG10_RS20730	COG2132	Multicopper oxidase
GWG10_RS20755	COG5642	Protein of unknown function (DUF2384)
GWG10_RS20760	COG0659	secondary active sulfate transmembrane transporter activity
GWG10_RS20765	COG0589	response to stress
GWG10_RS20780	COG1278	Cold shock
GWG10_RS20785	COG2205	protein histidine kinase activity
GWG10_RS20790	COG0745	RESPONSE REGULATOR receiver
GWG10_RS20810	COG3706	GGDEF domain
GWG10_RS20815	COG0347	Belongs to the P(II) protein family
GWG10_RS20820	COG0004	ammonium transporteR
GWG10_RS20830	COG0346	lactoylglutathione lyase activity
GWG10_RS20845	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWG10_RS20850	COG1074	ATP-dependent DNA helicase activity
GWG10_RS20855	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GWG10_RS20860	COG2259	Doxx family
GWG10_RS20865	COG1741	Belongs to the pirin family
GWG10_RS20875	COG0583	DNA-binding transcription factor activity
GWG10_RS20900	COG1175	transmembrane transport
GWG10_RS20910	COG3842	ATPase activity
GWG10_RS20940	COG0456	acetyltransferase
GWG10_RS20945	COG0753	catalase activity
GWG10_RS20965	COG0494	nUDIX hydrolase
GWG10_RS20970	COG0628	permease
GWG10_RS20980	COG2957	Belongs to the agmatine deiminase family
GWG10_RS20995	COG2957	Belongs to the agmatine deiminase family
GWG10_RS21000	COG0583	DNA-binding transcription factor activity
GWG10_RS21015	COG1461	Dihydroxyacetone kinase
GWG10_RS21020	COG2376	Dihydroxyacetone kinase
GWG10_RS21025	COG2252	PERMEase
GWG10_RS21030	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GWG10_RS21065	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GWG10_RS21070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWG10_RS21075	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWG10_RS21080	COG0049	tRNA binding
GWG10_RS21085	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GWG10_RS21090	COG2168	tRNA wobble position uridine thiolation
GWG10_RS21100	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GWG10_RS21105	COG0251	oxidation-reduction process
GWG10_RS21110	COG2964	Protein conserved in bacteria
GWG10_RS21115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GWG10_RS21120	COG0085	RNA polymerase activity
GWG10_RS21125	COG0222	ribosome binding
GWG10_RS21130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GWG10_RS21135	COG0081	regulation of translation
GWG10_RS21140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GWG10_RS21145	COG0250	Participates in transcription elongation, termination and antitermination
GWG10_RS21160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWG10_RS21185	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GWG10_RS21190	COG0569	domain protein
GWG10_RS21195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWG10_RS21200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GWG10_RS21205	COG3005	denitrification pathway
GWG10_RS21210	COG0243	molybdopterin cofactor binding
GWG10_RS21225	COG0745	RESPONSE REGULATOR receiver
GWG10_RS21245	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GWG10_RS21255	COG2204	response regulator
GWG10_RS21265	COG2205	protein histidine kinase activity
GWG10_RS21285	COG0517	IMP dehydrogenase activity
GWG10_RS21285	COG0516	GMP reductase activity
GWG10_RS21295	COG1522	sequence-specific DNA binding
GWG10_RS21300	COG2502	aspartate--ammonia ligase
GWG10_RS21315	COG0583	DNA-binding transcription factor activity
GWG10_RS21320	COG0542	response to heat
GWG10_RS21330	COG0564	pseudouridine synthase activity
GWG10_RS21335	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWG10_RS21340	COG3681	Belongs to the UPF0597 family
GWG10_RS21345	COG2964	Protein conserved in bacteria
GWG10_RS21350	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GWG10_RS21355	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GWG10_RS21360	COG1979	alcohol dehydrogenase
GWG10_RS21365	COG2207	Transcriptional regulator
GWG10_RS21370	COG3040	lipid binding
GWG10_RS21390	COG0583	DNA-binding transcription factor activity
GWG10_RS21410	COG0540	Belongs to the ATCase OTCase family
GWG10_RS21415	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GWG10_RS21420	COG1438	arginine binding
GWG10_RS21425	COG1288	antiporter activity
GWG10_RS21430	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWG10_RS21470	COG3250	beta-galactosidase activity
GWG10_RS21480	COG1609	Transcriptional regulator
GWG10_RS21485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWG10_RS21495	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWG10_RS21500	COG2017	converts alpha-aldose to the beta-anomer
GWG10_RS21505	COG0667	Aldo Keto reductase
GWG10_RS21510	COG1968	undecaprenyl-diphosphatase activity
GWG10_RS21515	COG3806	Anti-sigma factor
GWG10_RS21520	COG1595	DNA-templated transcription, initiation
GWG10_RS21540	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GWG10_RS21545	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GWG10_RS21565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWG10_RS21570	COG1131	(ABC) transporter
GWG10_RS21575	COG0842	Transport permease protein
GWG10_RS21580	COG0842	Transport permease protein
GWG10_RS21585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWG10_RS21595	COG2116	formate transmembrane transporter activity
GWG10_RS21600	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWG10_RS21600	COG1648	precorrin-2 dehydrogenase activity
GWG10_RS21605	COG2239	Acts as a magnesium transporter
GWG10_RS21610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GWG10_RS21620	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GWG10_RS21630	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GWG10_RS21640	COG0514	ATP-dependent DNA helicase (RecQ)
GWG10_RS21645	COG2050	protein possibly involved in aromatic compounds catabolism
GWG10_RS21660	COG2258	MOSC domain
GWG10_RS21665	COG1177	transmembrane transport
GWG10_RS21670	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWG10_RS21675	COG3842	ATPase activity
GWG10_RS21695	COG0174	glutamine synthetase
GWG10_RS21715	COG3045	CreA protein
GWG10_RS21720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWG10_RS21725	COG0443	Heat shock 70 kDa protein
GWG10_RS21740	COG0366	Alpha amylase catalytic
GWG10_RS21755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWG10_RS21760	COG0745	RESPONSE REGULATOR receiver
GWG10_RS21770	COG2205	protein histidine kinase activity
GWG10_RS21780	COG0281	malic enzyme
GWG10_RS21785	COG0702	epimerase
GWG10_RS21790	COG0254	rRNA binding
GWG10_RS21795	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GWG10_RS21800	COG1309	transcriptional regulator
GWG10_RS21820	COG0129	dihydroxy-acid dehydratase activity
GWG10_RS21830	COG3978	acetolactate synthase activity
GWG10_RS21840	COG0606	chelatase, subunit chli
GWG10_RS21845	COG0204	Acyl-transferase
GWG10_RS21850	COG0204	Acyl-transferase
GWG10_RS21855	COG1683	Conserved Protein
GWG10_RS21865	COG1335	isochorismatase
GWG10_RS21875	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GWG10_RS21880	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GWG10_RS21890	COG3084	Protein conserved in bacteria
GWG10_RS21895	COG4251	negative regulation of phosphorylation
GWG10_RS21895	COG3706	GGDEF domain
GWG10_RS21895	COG2203	Gaf domain
GWG10_RS21895	COG5001	Diguanylate cyclase
GWG10_RS21910	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GWG10_RS21920	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GWG10_RS21925	COG1561	YicC-like family, N-terminal region
GWG10_RS21935	COG1519	Transferase
GWG10_RS21940	COG0859	PFAM glycosyl transferase family 9
GWG10_RS21945	COG0463	Glycosyl transferase, family 2
GWG10_RS21950	COG0859	PFAM glycosyl transferase family 9
GWG10_RS21955	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GWG10_RS21960	COG2990	Protein conserved in bacteria
GWG10_RS21965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GWG10_RS21975	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GWG10_RS21980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GWG10_RS21985	COG2003	Belongs to the UPF0758 family
GWG10_RS21990	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GWG10_RS21995	COG0756	dUTP diphosphatase activity
GWG10_RS22000	COG1309	transcriptional regulator
GWG10_RS22010	COG0668	transmembrane transport
GWG10_RS22020	COG0166	Belongs to the GPI family
GWG10_RS22025	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GWG10_RS22030	COG0583	DNA-binding transcription factor activity
GWG10_RS22040	COG1042	CoA-binding domain protein
GWG10_RS22040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWG10_RS22040	COG0045	succinate-CoA ligase (ADP-forming) activity
GWG10_RS22065	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GWG10_RS22070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWG10_RS22075	COG1739	Uncharacterized protein family UPF0029
GWG10_RS22080	COG0006	proline dipeptidase activity
GWG10_RS22085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWG10_RS22090	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWG10_RS22090	COG1024	Enoyl-CoA hydratase
GWG10_RS22095	COG0183	Belongs to the thiolase family
GWG10_RS22100	COG0745	RESPONSE REGULATOR receiver
GWG10_RS22135	COG0425	Belongs to the sulfur carrier protein TusA family
GWG10_RS22140	COG0251	oxidation-reduction process
GWG10_RS22160	COG2885	chlorophyll binding
GWG10_RS22170	COG1335	isochorismatase
GWG10_RS22175	COG2818	Glycosylase
GWG10_RS22180	COG0752	glycyl-tRNA synthetase alpha subunit
GWG10_RS22185	COG0751	glycine-tRNA ligase activity
GWG10_RS22210	COG5001	Diguanylate cyclase
GWG10_RS22210	COG3706	GGDEF domain
GWG10_RS22210	COG4251	negative regulation of phosphorylation
GWG10_RS22210	COG2203	Gaf domain
GWG10_RS22230	COG0814	amino acid
GWG10_RS22235	COG0814	amino acid
GWG10_RS22240	COG3033	Beta-eliminating lyase
GWG10_RS22250	COG0348	domain, Protein
GWG10_RS22260	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWG10_RS22265	COG0426	domain, Protein
GWG10_RS22265	COG1773	rubredoxin
GWG10_RS22270	COG3604	Transcriptional regulator
GWG10_RS22275	COG1609	Transcriptional regulator
GWG10_RS22315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWG10_RS22330	COG2960	long-chain fatty acid transporting porin activity
GWG10_RS22340	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GWG10_RS22355	COG3118	belongs to the thioredoxin family
GWG10_RS22360	COG0513	Belongs to the DEAD box helicase family
GWG10_RS22365	COG0248	Ppx GppA phosphatase
GWG10_RS22375	COG0742	ribosomal rna small subunit methyltransferase
GWG10_RS22395	COG0084	hydrolase, TatD family'
GWG10_RS22400	COG0805	protein transport
GWG10_RS22405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWG10_RS22410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWG10_RS22415	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GWG10_RS22420	COG3165	ubiquinone biosynthetic process from chorismate
GWG10_RS22430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GWG10_RS22435	COG0402	S-adenosylhomocysteine deaminase activity
GWG10_RS22475	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GWG10_RS22480	COG0848	biopolymer transport protein
GWG10_RS22485	COG0811	peptide transport
GWG10_RS22490	COG0811	peptide transport
GWG10_RS22500	COG2771	luxR family
GWG10_RS22515	COG1349	DNA-binding transcription factor activity
GWG10_RS22525	COG1028	Short-chain dehydrogenase reductase Sdr
GWG10_RS22560	COG0166	Belongs to the GPI family
GWG10_RS22565	COG3039	Transposase
GWG10_RS22570	COG3039	Transposase
GWG10_RS22585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GWG10_RS22590	COG1349	DNA-binding transcription factor activity
GWG10_RS22595	COG0745	RESPONSE REGULATOR receiver
GWG10_RS22600	COG2205	protein histidine kinase activity
GWG10_RS22610	COG4452	Inner membrane protein CreD
GWG10_RS22615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GWG10_RS22620	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GWG10_RS22625	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GWG10_RS22630	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GWG10_RS22635	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GWG10_RS22640	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GWG10_RS22645	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GWG10_RS22655	COG0356	it plays a direct role in the translocation of protons across the membrane
GWG10_RS22665	COG1475	DNA binding
GWG10_RS22670	COG1192	Involved in chromosome partitioning
GWG10_RS22675	COG0357	Ribosomal RNA small subunit methyltransferase G
GWG10_RS22680	COG0445	tRNA wobble uridine modification
GWG10_RS22685	COG0716	FMN binding
GWG10_RS22690	COG4774	siderophore transport
GWG10_RS22695	COG4615	Cyclic peptide transporter
GWG10_RS22700	COG1120	ATPase activity
GWG10_RS22705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWG10_RS22715	COG3550	peptidyl-serine autophosphorylation
GWG10_RS22740	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GWG10_RS22745	COG0706	membrane insertase activity
GWG10_RS22750	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GWG10_RS22755	COG0594	ribonuclease P activity
GWG10_RS22760	COG0230	Belongs to the bacterial ribosomal protein bL34 family