locus-tag	class	description
GWC92_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GWC92_RS00010	COG0592	DNA-directed DNA polymerase activity
GWC92_RS00020	COG0187	DNA topoisomerase II activity
GWC92_RS00025	COG2207	Transcriptional regulator
GWC92_RS00030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GWC92_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
GWC92_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
GWC92_RS00045	COG3977	Valine--pyruvate aminotransferase
GWC92_RS00060	COG2814	Major facilitator Superfamily
GWC92_RS00065	COG0745	RESPONSE REGULATOR receiver
GWC92_RS00070	COG2205	protein histidine kinase activity
GWC92_RS00120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWC92_RS00125	COG4191	Histidine kinase
GWC92_RS00125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWC92_RS00130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWC92_RS00135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWC92_RS00140	COG1309	transcriptional regulator
GWC92_RS00170	COG0561	phosphatase activity
GWC92_RS00175	COG2267	carboxylic ester hydrolase activity
GWC92_RS00180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWC92_RS00185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWC92_RS00190	COG1758	RNA polymerase activity
GWC92_RS00200	COG0859	PFAM glycosyl transferase family 9
GWC92_RS00205	COG3642	lipopolysaccharide core region biosynthetic process
GWC92_RS00245	COG0589	response to stress
GWC92_RS00250	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GWC92_RS00255	COG3706	GGDEF domain
GWC92_RS00260	COG1528	Iron-storage protein
GWC92_RS00265	COG2081	HI0933 family
GWC92_RS00270	COG2223	nitrite transmembrane transporter activity
GWC92_RS00275	COG1280	lysine exporter protein (LysE YggA)
GWC92_RS00290	COG3188	usher protein
GWC92_RS00310	COG2205	protein histidine kinase activity
GWC92_RS00310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWC92_RS00320	COG3275	phosphorelay sensor kinase activity
GWC92_RS00325	COG3279	Response regulator of the LytR AlgR family
GWC92_RS00330	COG2223	nitrite transmembrane transporter activity
GWC92_RS00335	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GWC92_RS00340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GWC92_RS00385	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GWC92_RS00390	COG2166	iron-sulfur cluster assembly
GWC92_RS00395	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GWC92_RS00415	COG1063	alcohol dehydrogenase
GWC92_RS00420	COG0156	8-amino-7-oxononanoate synthase activity
GWC92_RS00430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWC92_RS00475	COG1609	Transcriptional regulator
GWC92_RS00490	COG1580	Controls the rotational direction of flagella during chemotaxis
GWC92_RS00495	COG3161	chorismate lyase activity
GWC92_RS00500	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GWC92_RS00505	COG2937	Belongs to the GPAT DAPAT family
GWC92_RS00510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWC92_RS00525	COG0534	Mate efflux family protein
GWC92_RS00530	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GWC92_RS00535	COG2205	protein histidine kinase activity
GWC92_RS00540	COG0745	RESPONSE REGULATOR receiver
GWC92_RS00550	COG1045	serine acetyltransferase
GWC92_RS00560	COG3074	FtsZ-dependent cytokinesis
GWC92_RS00565	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GWC92_RS00570	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWC92_RS00570	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWC92_RS00575	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GWC92_RS00615	COG1609	Transcriptional regulator
GWC92_RS00620	COG3250	beta-galactosidase activity
GWC92_RS00625	COG2731	YhcH YjgK YiaL family protein
GWC92_RS00630	COG0531	amino acid
GWC92_RS00635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWC92_RS00640	COG0531	amino acid
GWC92_RS00645	COG0385	Bile acid
GWC92_RS00650	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWC92_RS00675	COG0583	DNA-binding transcription factor activity
GWC92_RS00700	COG0210	DNA helicase
GWC92_RS00710	COG1943	Transposase
GWC92_RS00715	COG0583	DNA-binding transcription factor activity
GWC92_RS00750	COG0583	DNA-binding transcription factor activity
GWC92_RS00765	COG1280	lysine exporter protein (LysE YggA)
GWC92_RS00775	COG2962	Rard protein
GWC92_RS00785	COG1012	belongs to the aldehyde dehydrogenase family
GWC92_RS00790	COG1396	sequence-specific DNA binding
GWC92_RS00805	COG0519	Catalyzes the synthesis of GMP from XMP
GWC92_RS00805	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWC92_RS00815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWC92_RS00835	COG1322	Protein conserved in bacteria
GWC92_RS00840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWC92_RS00845	COG0569	domain protein
GWC92_RS00850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWC92_RS00850	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWC92_RS00855	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GWC92_RS00860	COG0242	peptide deformylase activity
GWC92_RS00870	COG0758	DNA mediated transformation
GWC92_RS00875	COG2922	Belongs to the Smg family
GWC92_RS00880	COG0551	DNA topoisomerase type I activity
GWC92_RS00885	COG0009	L-threonylcarbamoyladenylate synthase
GWC92_RS00890	COG0408	coproporphyrinogen oxidase activity
GWC92_RS00895	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GWC92_RS00900	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GWC92_RS00910	COG3078	GTPase activator activity
GWC92_RS00920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWC92_RS00925	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GWC92_RS00935	COG3852	Histidine kinase
GWC92_RS00945	COG0174	glutamine synthetase
GWC92_RS00955	COG1295	ribonuclease BN
GWC92_RS00960	COG1490	D-aminoacyl-tRNA deacylase activity
GWC92_RS00970	COG0456	acetyltransferase
GWC92_RS00980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWC92_RS00985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWC92_RS00990	COG2610	gluconate transmembrane transporter activity
GWC92_RS00995	COG3265	gluconokinase activity
GWC92_RS01000	COG0129	dihydroxy-acid dehydratase activity
GWC92_RS01005	COG0800	Aldolase
GWC92_RS01020	COG1609	Transcriptional regulator
GWC92_RS01030	COG4942	peptidase
GWC92_RS01035	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GWC92_RS01040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWC92_RS01045	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GWC92_RS01050	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GWC92_RS01055	COG0316	Belongs to the HesB IscA family
GWC92_RS01055	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GWC92_RS01060	COG1040	competence protein
GWC92_RS01065	COG0596	Alpha beta hydrolase
GWC92_RS01080	COG2183	response to ionizing radiation
GWC92_RS01085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWC92_RS01090	COG0745	RESPONSE REGULATOR receiver
GWC92_RS01095	COG2205	protein histidine kinase activity
GWC92_RS01105	COG0051	transcription antitermination factor activity, RNA binding
GWC92_RS01110	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GWC92_RS01115	COG0088	Forms part of the polypeptide exit tunnel
GWC92_RS01120	COG0089	rRNA binding
GWC92_RS01125	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GWC92_RS01130	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GWC92_RS01135	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GWC92_RS01140	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GWC92_RS01145	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GWC92_RS01150	COG0255	Belongs to the universal ribosomal protein uL29 family
GWC92_RS01155	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GWC92_RS01160	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GWC92_RS01165	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GWC92_RS01170	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GWC92_RS01175	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GWC92_RS01180	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GWC92_RS01185	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GWC92_RS01190	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GWC92_RS01195	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GWC92_RS01200	COG1841	ribosomal large subunit assembly
GWC92_RS01205	COG0200	Binds to the 23S rRNA
GWC92_RS01210	COG0201	protein transport
GWC92_RS01215	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWC92_RS01220	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GWC92_RS01225	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GWC92_RS01230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GWC92_RS01235	COG0202	RNA polymerase activity
GWC92_RS01240	COG0203	ribosomal protein L17
GWC92_RS01295	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWC92_RS01300	COG0583	DNA-binding transcription factor activity
GWC92_RS01305	COG4221	oxidoreductase activity
GWC92_RS01320	COG1770	oligopeptidase
GWC92_RS01325	COG2358	TRAP transporter, solute receptor (TAXI family
GWC92_RS01340	COG3714	YhhN family
GWC92_RS01355	COG0583	DNA-binding transcription factor activity
GWC92_RS01365	COG1301	dicarboxylic acid transport
GWC92_RS01375	COG2095	MarC family integral membrane protein
GWC92_RS01385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWC92_RS01395	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GWC92_RS01405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWC92_RS01430	COG0742	ribosomal rna small subunit methyltransferase
GWC92_RS01435	COG0552	protein localization to endoplasmic reticulum
GWC92_RS01440	COG2884	Cell division ATP-binding protein ftsE
GWC92_RS01445	COG2177	Part of the ABC transporter FtsEX involved in
GWC92_RS01455	COG0288	reversible hydration of carbon dioxide
GWC92_RS01460	COG2188	Transcriptional regulator
GWC92_RS01465	COG1228	amidohydrolase
GWC92_RS01470	COG0010	Belongs to the arginase family
GWC92_RS01475	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GWC92_RS01480	COG2986	histidine ammonia-lyase
GWC92_RS01485	COG0387	Pfam Sodium calcium exchanger
GWC92_RS01490	COG2200	EAL domain
GWC92_RS01545	COG1459	type II secretion system
GWC92_RS01590	COG1077	Cell shape determining protein MreB Mrl
GWC92_RS01595	COG1792	Involved in formation and maintenance of cell shape
GWC92_RS01600	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GWC92_RS01605	COG0424	maF-like protein
GWC92_RS01610	COG1530	ribonuclease E activity
GWC92_RS01615	COG3164	Protein of unknown function
GWC92_RS01620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWC92_RS01625	COG0312	modulator of DNA gyrase
GWC92_RS01640	COG0477	Major facilitator Superfamily
GWC92_RS01650	COG2321	neutral zinc metallopeptidase
GWC92_RS01685	COG0189	ligase activity
GWC92_RS01690	COG0642	Histidine kinase
GWC92_RS01695	COG0745	RESPONSE REGULATOR receiver
GWC92_RS01710	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GWC92_RS01715	COG0352	thiamine-phosphate diphosphorylase activity
GWC92_RS01720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWC92_RS01730	COG2022	thiamine diphosphate biosynthetic process
GWC92_RS01735	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GWC92_RS01755	COG0110	maltose O-acetyltransferase activity
GWC92_RS01765	COG2199	diguanylate cyclase activity
GWC92_RS01765	COG2203	Gaf domain
GWC92_RS01770	COG3932	Exopolysaccharide synthesis, ExoD
GWC92_RS01785	COG1733	regulation of RNA biosynthetic process
GWC92_RS01810	COG2226	methyltransferase
GWC92_RS01820	COG1494	fructose-1,6-bisphosphatase
GWC92_RS01830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GWC92_RS01835	COG5007	Belongs to the BolA IbaG family
GWC92_RS01845	COG2854	intermembrane phospholipid transfer
GWC92_RS01850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GWC92_RS01855	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GWC92_RS01860	COG1127	ABC transporter
GWC92_RS01865	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GWC92_RS01865	COG0517	IMP dehydrogenase activity
GWC92_RS01870	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GWC92_RS01880	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GWC92_RS01885	COG1137	ATPase activity
GWC92_RS01890	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GWC92_RS01900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWC92_RS01905	COG1660	Displays ATPase and GTPase activities
GWC92_RS01910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWC92_RS01930	COG3964	amidohydrolase
GWC92_RS01960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWC92_RS01965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWC92_RS01975	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GWC92_RS01980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GWC92_RS01985	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GWC92_RS01990	COG0723	plastoquinol--plastocyanin reductase activity
GWC92_RS01995	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GWC92_RS02000	COG2857	Cytochrome c1
GWC92_RS02005	COG0625	glutathione transferase activity
GWC92_RS02010	COG2969	positive regulation of protein catabolic process
GWC92_RS02015	COG2823	Periplasmic or secreted lipoprotein
GWC92_RS02020	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GWC92_RS02025	COG0792	nuclease activity
GWC92_RS02030	COG3107	peptidoglycan biosynthetic process
GWC92_RS02035	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GWC92_RS02045	COG2001	Belongs to the MraZ family
GWC92_RS02050	COG0275	rRNA processing
GWC92_RS02055	COG3116	cell division
GWC92_RS02060	COG0768	penicillin binding
GWC92_RS02065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GWC92_RS02070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GWC92_RS02075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWC92_RS02080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GWC92_RS02085	COG0772	Belongs to the SEDS family
GWC92_RS02090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWC92_RS02095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWC92_RS02100	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GWC92_RS02105	COG0849	cell division
GWC92_RS02110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GWC92_RS02115	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GWC92_RS02125	COG0653	protein targeting
GWC92_RS02135	COG0494	nUDIX hydrolase
GWC92_RS02140	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GWC92_RS02145	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GWC92_RS02160	COG1459	type II secretion system
GWC92_RS02165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWC92_RS02190	COG2186	Transcriptional regulator
GWC92_RS02195	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GWC92_RS02200	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWC92_RS02205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWC92_RS02215	COG0840	transmembrane signaling receptor activity
GWC92_RS02220	COG0840	transmembrane signaling receptor activity
GWC92_RS02225	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWC92_RS02230	COG1049	propionate catabolic process, 2-methylcitrate cycle
GWC92_RS02235	COG2200	EAL domain
GWC92_RS02245	COG1280	lysine exporter protein (LysE YggA)
GWC92_RS02255	COG0523	cobalamin synthesis protein
GWC92_RS02260	COG0477	Major facilitator Superfamily
GWC92_RS02275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GWC92_RS02280	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GWC92_RS02325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GWC92_RS02355	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GWC92_RS02360	COG0732	type I restriction modification DNA specificity domain
GWC92_RS02365	COG1401	restriction endodeoxyribonuclease activity
GWC92_RS02365	COG1401	restriction endodeoxyribonuclease activity
GWC92_RS02375	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GWC92_RS02415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWC92_RS02430	COG1546	Belongs to the CinA family
GWC92_RS02435	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GWC92_RS02440	COG2137	regulation of response to DNA damage stimulus
GWC92_RS02445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWC92_RS02450	COG0527	aspartate kinase activity
GWC92_RS02455	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GWC92_RS02490	COG1686	Belongs to the peptidase S11 family
GWC92_RS02495	COG0586	Pfam SNARE associated Golgi protein
GWC92_RS02500	COG1253	flavin adenine dinucleotide binding
GWC92_RS02505	COG0525	valine-tRNA ligase activity
GWC92_RS02510	COG2927	DNA polymerase III (CHI subunit)
GWC92_RS02515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GWC92_RS02520	COG0795	lipopolysaccharide-transporting ATPase activity
GWC92_RS02525	COG0795	lipopolysaccharide-transporting ATPase activity
GWC92_RS02545	COG0004	ammonium transporteR
GWC92_RS02550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWC92_RS02565	COG4968	Prepilin-type N-terminal cleavage methylation domain
GWC92_RS02570	COG0084	hydrolase, TatD family'
GWC92_RS02575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWC92_RS02585	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GWC92_RS02590	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GWC92_RS02595	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GWC92_RS02600	COG0813	purine-nucleoside phosphorylase activity
GWC92_RS02605	COG5002	protein histidine kinase activity
GWC92_RS02605	COG5001	Diguanylate cyclase
GWC92_RS02605	COG3447	MASE1 domain protein
GWC92_RS02615	COG0560	Phosphoserine phosphatase
GWC92_RS02630	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GWC92_RS02640	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GWC92_RS02645	COG0776	regulation of translation
GWC92_RS02660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWC92_RS02665	COG0735	belongs to the Fur family
GWC92_RS02685	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GWC92_RS02690	COG0513	Belongs to the DEAD box helicase family
GWC92_RS02695	COG3022	response to hydroperoxide
GWC92_RS02700	COG2805	Type II/IV secretion system protein
GWC92_RS02710	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWC92_RS02715	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GWC92_RS02720	COG0762	integral membrane protein
GWC92_RS02725	COG1872	DUF167
GWC92_RS02745	COG3112	Uncharacterised protein family (UPF0231)
GWC92_RS02750	COG3835	regulator
GWC92_RS02755	COG2610	gluconate transmembrane transporter activity
GWC92_RS02760	COG1929	Belongs to the glycerate kinase type-1 family
GWC92_RS02775	COG0583	DNA-binding transcription factor activity
GWC92_RS02780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWC92_RS02795	COG0347	Belongs to the P(II) protein family
GWC92_RS02800	COG1840	ABC-type Fe3 transport system, periplasmic component
GWC92_RS02810	COG3842	ATPase activity
GWC92_RS02815	COG2837	iron assimilation
GWC92_RS02820	COG1438	arginine binding
GWC92_RS02825	COG1126	abc transporter atp-binding protein
GWC92_RS02830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWC92_RS02835	COG4215	(ABC) transporter
GWC92_RS02840	COG4160	amino acid transport
GWC92_RS02845	COG0039	L-malate dehydrogenase activity
GWC92_RS02850	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GWC92_RS02855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWC92_RS02855	COG1017	nitric oxide dioxygenase activity
GWC92_RS02865	COG4536	flavin adenine dinucleotide binding
GWC92_RS02870	COG4137	Cytochrome C assembly protein
GWC92_RS02875	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWC92_RS02880	COG0228	four-way junction DNA binding
GWC92_RS02885	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GWC92_RS02890	COG0336	Belongs to the RNA methyltransferase TrmD family
GWC92_RS02895	COG0335	large ribosomal subunit rRNA binding
GWC92_RS02910	COG1051	belongs to the nudix hydrolase family
GWC92_RS02920	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GWC92_RS02925	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GWC92_RS02930	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GWC92_RS02940	COG0583	DNA-binding transcription factor activity
GWC92_RS02945	COG0640	Transcriptional regulator
GWC92_RS02950	COG0268	Binds directly to 16S ribosomal RNA
GWC92_RS02955	COG0728	peptidoglycan biosynthetic process
GWC92_RS02960	COG0196	riboflavin kinase activity
GWC92_RS02965	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GWC92_RS02970	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GWC92_RS02975	COG1047	Peptidyl-prolyl cis-trans
GWC92_RS02980	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GWC92_RS02985	COG4968	Prepilin-type N-terminal cleavage methylation domain
GWC92_RS03030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWC92_RS03030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GWC92_RS03045	COG1854	S-ribosylhomocysteine lyase activity
GWC92_RS03050	COG3706	GGDEF domain
GWC92_RS03055	COG0557	exoribonuclease II activity
GWC92_RS03060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWC92_RS03070	COG2153	protein acetylation
GWC92_RS03080	COG1914	H( )-stimulated, divalent metal cation uptake system
GWC92_RS03085	COG0360	Binds together with S18 to 16S ribosomal RNA
GWC92_RS03090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GWC92_RS03095	COG0359	binds to the 23S rRNA
GWC92_RS03135	COG1238	metal cluster binding
GWC92_RS03140	COG0612	Peptidase, M16
GWC92_RS03145	COG2918	glutathione biosynthetic process
GWC92_RS03150	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GWC92_RS03155	COG1027	Aspartate ammonia-lyase
GWC92_RS03160	COG3030	protein affecting phage T7 exclusion by the F plasmid
GWC92_RS03165	COG0534	Mate efflux family protein
GWC92_RS03170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GWC92_RS03175	COG0459	protein refolding
GWC92_RS03195	COG0564	pseudouridine synthase activity
GWC92_RS03200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWC92_RS03235	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GWC92_RS03250	COG4208	sulfate ABC transporter
GWC92_RS03255	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GWC92_RS03260	COG0583	DNA-binding transcription factor activity
GWC92_RS03265	COG3397	chitin binding
GWC92_RS03295	COG1328	CTP reductase activity
GWC92_RS03300	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GWC92_RS03315	COG1448	Aminotransferase
GWC92_RS03340	COG1215	transferase activity, transferring glycosyl groups
GWC92_RS03350	COG0457	Tetratricopeptide repeat
GWC92_RS03350	COG3118	belongs to the thioredoxin family
GWC92_RS03355	COG0457	Tetratricopeptide repeat
GWC92_RS03355	COG3118	belongs to the thioredoxin family
GWC92_RS03395	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GWC92_RS03400	COG0513	Belongs to the DEAD box helicase family
GWC92_RS03405	COG0840	transmembrane signaling receptor activity
GWC92_RS03415	COG4166	transmembrane transport
GWC92_RS03430	COG1024	Enoyl-CoA hydratase
GWC92_RS03445	COG4221	oxidoreductase activity
GWC92_RS03450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWC92_RS03455	COG0442	prolyl-tRNA aminoacylation
GWC92_RS03460	COG0840	transmembrane signaling receptor activity
GWC92_RS03465	COG0632	four-way junction helicase activity
GWC92_RS03470	COG2255	four-way junction helicase activity
GWC92_RS03480	COG1271	oxidase subunit
GWC92_RS03485	COG1294	oxidase, subunit
GWC92_RS03490	COG4890	Cyd operon protein YbgT
GWC92_RS03495	COG3790	cyd operon protein YbgE
GWC92_RS03500	COG0824	Thioesterase
GWC92_RS03505	COG0811	peptide transport
GWC92_RS03520	COG0823	Involved in the tonB-independent uptake of proteins
GWC92_RS03525	COG2885	chlorophyll binding
GWC92_RS03530	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GWC92_RS03605	COG0840	transmembrane signaling receptor activity
GWC92_RS03610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GWC92_RS03620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWC92_RS03625	COG1640	4-alpha-glucanotransferase
GWC92_RS03630	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GWC92_RS03660	COG2130	NADP-dependent
GWC92_RS03665	COG1846	Transcriptional regulator
GWC92_RS03695	COG0561	phosphatase activity
GWC92_RS03710	COG0733	neurotransmitter:sodium symporter activity
GWC92_RS03715	COG0733	neurotransmitter:sodium symporter activity
GWC92_RS03730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWC92_RS03745	COG1794	racemase activity, acting on amino acids and derivatives
GWC92_RS03755	COG1022	Amp-dependent synthetase and ligase
GWC92_RS03765	COG0456	acetyltransferase
GWC92_RS03815	COG2207	Transcriptional regulator
GWC92_RS03815	COG1917	Cupin 2, conserved barrel domain protein
GWC92_RS03825	COG0513	Belongs to the DEAD box helicase family
GWC92_RS03865	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
GWC92_RS03875	COG1136	(ABC) transporter
GWC92_RS03875	COG0577	efflux transmembrane transporter activity
GWC92_RS03880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWC92_RS03885	COG0745	RESPONSE REGULATOR receiver
GWC92_RS03890	COG2205	protein histidine kinase activity
GWC92_RS03945	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWC92_RS03955	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GWC92_RS03960	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GWC92_RS03965	COG1178	ABC-type Fe3 transport system permease component
GWC92_RS03970	COG4143	(ABC) transporter
GWC92_RS03985	COG0066	3-isopropylmalate dehydratase activity
GWC92_RS03990	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GWC92_RS03995	COG0473	3-isopropylmalate dehydrogenase activity
GWC92_RS04000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWC92_RS04010	COG0671	phosphoesterase, PA-phosphatase related
GWC92_RS04025	COG0028	Belongs to the TPP enzyme family
GWC92_RS04030	COG0440	acetolactate synthase activity
GWC92_RS04035	COG0857	belongs to the CobB CobQ family
GWC92_RS04035	COG0280	phosphate acetyltransferase
GWC92_RS04040	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GWC92_RS04045	COG3092	negative regulation of chromosome organization
GWC92_RS04050	COG3013	Belongs to the UPF0304 family
GWC92_RS04055	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWC92_RS04060	COG2716	regulation of RNA biosynthetic process
GWC92_RS04065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWC92_RS04070	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GWC92_RS04075	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GWC92_RS04090	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GWC92_RS04110	COG0784	Response regulator, receiver
GWC92_RS04110	COG2198	Histidine kinase
GWC92_RS04110	COG5002	protein histidine kinase activity
GWC92_RS04115	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GWC92_RS04145	COG1464	Belongs to the NlpA lipoprotein family
GWC92_RS04150	COG2011	ABC-type metal ion transport system permease component
GWC92_RS04155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWC92_RS04175	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GWC92_RS04175	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GWC92_RS04180	COG0802	atpase or kinase
GWC92_RS04190	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWC92_RS04195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GWC92_RS04200	COG1923	regulation of RNA biosynthetic process
GWC92_RS04205	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GWC92_RS04210	COG0330	HflC and HflK could
GWC92_RS04215	COG0330	HflC and HflK could
GWC92_RS04220	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GWC92_RS04225	COG0142	geranyltranstransferase activity
GWC92_RS04230	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GWC92_RS04235	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GWC92_RS04240	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GWC92_RS04250	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GWC92_RS04255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWC92_RS04265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWC92_RS04270	COG2967	ApaG domain
GWC92_RS04275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GWC92_RS04290	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GWC92_RS04295	COG3178	'Phosphotransferase
GWC92_RS04300	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GWC92_RS04305	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GWC92_RS04310	COG2252	PERMEase
GWC92_RS04320	COG0488	(ABC) transporter
GWC92_RS04325	COG0582	viral genome integration into host DNA
GWC92_RS04390	COG1846	Transcriptional regulator
GWC92_RS04475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWC92_RS04480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWC92_RS04485	COG2135	peptidase activity
GWC92_RS04535	COG1802	Transcriptional regulator
GWC92_RS04535	COG4626	Terminase
GWC92_RS04550	COG0616	signal peptide processing
GWC92_RS04660	COG0741	lytic transglycosylase activity
GWC92_RS04665	COG0463	Glycosyl transferase, family 2
GWC92_RS04675	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GWC92_RS04700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWC92_RS04710	COG3721	Heme iron utilization protein
GWC92_RS04715	COG0748	coenzyme F420 binding
GWC92_RS04740	COG2814	Major facilitator Superfamily
GWC92_RS04745	COG2205	protein histidine kinase activity
GWC92_RS04745	COG2202	Pas domain
GWC92_RS04755	COG2226	methyltransferase
GWC92_RS04765	COG1765	OsmC-like protein
GWC92_RS04780	COG3954	Phosphoribulokinase
GWC92_RS04785	COG3089	Belongs to the UPF0270 family
GWC92_RS04790	COG5001	Diguanylate cyclase
GWC92_RS04790	COG4251	negative regulation of phosphorylation
GWC92_RS04790	COG3706	GGDEF domain
GWC92_RS04790	COG2203	Gaf domain
GWC92_RS04795	COG0429	hydrolase of the alpha beta-hydrolase fold
GWC92_RS04800	COG0784	Response regulator, receiver
GWC92_RS04800	COG0835	chemotaxis
GWC92_RS04810	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GWC92_RS04815	COG1047	Peptidyl-prolyl cis-trans
GWC92_RS04820	COG2900	Belongs to the SlyX family
GWC92_RS04830	COG0545	Peptidyl-prolyl cis-trans isomerase
GWC92_RS04835	COG2204	response regulator
GWC92_RS04855	COG0737	Belongs to the 5'-nucleotidase family
GWC92_RS04870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWC92_RS04875	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GWC92_RS04875	COG0506	proline dehydrogenase activity
GWC92_RS04875	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GWC92_RS04885	COG0114	fumarate hydratase activity
GWC92_RS04895	COG1566	PFAM secretion protein HlyD family protein
GWC92_RS04975	COG1280	lysine exporter protein (LysE YggA)
GWC92_RS04980	COG0826	peptidase U32
GWC92_RS04990	COG3813	Protein conserved in bacteria
GWC92_RS05010	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GWC92_RS05035	COG0300	oxidoreductase activity
GWC92_RS05045	COG0840	transmembrane signaling receptor activity
GWC92_RS05055	COG2610	gluconate transmembrane transporter activity
GWC92_RS05060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWC92_RS05065	COG3622	Belongs to the hyi family
GWC92_RS05070	COG0235	Class ii aldolase
GWC92_RS05080	COG2084	Dehydrogenase
GWC92_RS05085	COG1349	DNA-binding transcription factor activity
GWC92_RS05095	COG2133	pyrroloquinoline quinone binding
GWC92_RS05135	COG4397	Mu-like prophage major head subunit gpT
GWC92_RS05170	COG1605	Chorismate mutase
GWC92_RS05170	COG0077	Prephenate dehydratase
GWC92_RS05195	COG3272	Protein of unknown function (DUF1722)
GWC92_RS05200	COG0789	Transcriptional regulator
GWC92_RS05205	COG0415	Belongs to the DNA photolyase family
GWC92_RS05215	COG4221	oxidoreductase activity
GWC92_RS05230	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GWC92_RS05255	COG0783	Belongs to the Dps family
GWC92_RS05260	COG1151	hydroxylamine reductase activity
GWC92_RS05265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWC92_RS05270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWC92_RS05285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWC92_RS05290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWC92_RS05300	COG5000	phosphorelay sensor kinase activity
GWC92_RS05300	COG5002	protein histidine kinase activity
GWC92_RS05310	COG0659	secondary active sulfate transmembrane transporter activity
GWC92_RS05320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GWC92_RS05325	COG1666	GTP binding
GWC92_RS05335	COG2211	Major facilitator Superfamily
GWC92_RS05345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GWC92_RS05355	COG2813	Specifically methylates the guanine in position
GWC92_RS05360	COG0271	Belongs to the BolA IbaG family
GWC92_RS05365	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWC92_RS05370	COG1805	sodium ion transport
GWC92_RS05375	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWC92_RS05380	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWC92_RS05385	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWC92_RS05390	COG2871	sodium ion transport
GWC92_RS05395	COG1477	protein flavinylation
GWC92_RS05410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWC92_RS05415	COG0840	transmembrane signaling receptor activity
GWC92_RS05420	COG0583	DNA-binding transcription factor activity
GWC92_RS05435	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GWC92_RS05445	COG0473	3-isopropylmalate dehydrogenase activity
GWC92_RS05450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWC92_RS05455	COG1611	Belongs to the LOG family
GWC92_RS05460	COG3706	GGDEF domain
GWC92_RS05470	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GWC92_RS05470	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GWC92_RS05480	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GWC92_RS05505	COG3098	single-species biofilm formation
GWC92_RS05510	COG0564	pseudouridine synthase activity
GWC92_RS05525	COG4580	involved in the transport of maltose and maltodextrins
GWC92_RS05535	COG1263	PTS System
GWC92_RS05535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWC92_RS05545	COG2171	N-acyltransferase activity
GWC92_RS05550	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GWC92_RS05555	COG0024	Methionine aminopeptidase
GWC92_RS05560	COG0052	Belongs to the universal ribosomal protein uS2 family
GWC92_RS05565	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GWC92_RS05570	COG0528	UMP kinase activity
GWC92_RS05575	COG0233	cytoplasmic translational termination
GWC92_RS05580	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GWC92_RS05585	COG0575	Belongs to the CDS family
GWC92_RS05590	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GWC92_RS05595	COG0750	zinc metalloprotease
GWC92_RS05610	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWC92_RS05615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWC92_RS05620	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWC92_RS05625	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWC92_RS05630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GWC92_RS05635	COG0587	DNA-directed DNA polymerase activity
GWC92_RS05640	COG0825	malonyl-CoA metabolic process
GWC92_RS05655	COG0814	amino acid
GWC92_RS05660	COG0531	amino acid
GWC92_RS05670	COG0488	(ABC) transporter
GWC92_RS05680	COG3590	peptidase
GWC92_RS05685	COG0037	tRNA processing
GWC92_RS05690	COG3706	GGDEF domain
GWC92_RS05725	COG0366	Alpha amylase catalytic
GWC92_RS05740	COG0463	Glycosyl transferase, family 2
GWC92_RS05755	COG2989	Protein conserved in bacteria
GWC92_RS05760	COG3108	Peptidase M15
GWC92_RS05770	COG2860	membrane
GWC92_RS05780	COG1196	nuclear chromosome segregation
GWC92_RS05785	COG3115	cell septum assembly
GWC92_RS05790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GWC92_RS05800	COG1328	CTP reductase activity
GWC92_RS05805	COG0602	queuosine metabolic process
GWC92_RS05830	COG1566	PFAM secretion protein HlyD family protein
GWC92_RS05840	COG3290	protein histidine kinase activity
GWC92_RS05855	COG0667	Aldo Keto reductase
GWC92_RS05865	COG0697	spore germination
GWC92_RS05875	COG1012	belongs to the aldehyde dehydrogenase family
GWC92_RS05880	COG3284	Transcriptional regulator
GWC92_RS05885	COG3706	GGDEF domain
GWC92_RS05890	COG0346	lactoylglutathione lyase activity
GWC92_RS05895	COG0745	RESPONSE REGULATOR receiver
GWC92_RS05900	COG5002	protein histidine kinase activity
GWC92_RS05910	COG4783	chaperone-mediated protein folding
GWC92_RS05930	COG0545	Peptidyl-prolyl cis-trans isomerase
GWC92_RS05935	COG1131	(ABC) transporter
GWC92_RS05940	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GWC92_RS05950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWC92_RS05955	COG4597	amino acid ABC transporter
GWC92_RS05960	COG0765	amino acid transport
GWC92_RS05965	COG1126	abc transporter atp-binding protein
GWC92_RS05975	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GWC92_RS05980	COG0678	peroxiredoxin activity
GWC92_RS05990	COG0019	diaminopimelate decarboxylase activity
GWC92_RS05995	COG1115	amino acid carrier protein
GWC92_RS06000	COG0095	Lipoate-protein ligase
GWC92_RS06005	COG2233	PERMEase
GWC92_RS06025	COG2207	Transcriptional regulator
GWC92_RS06030	COG0281	malic enzyme
GWC92_RS06060	COG0733	neurotransmitter:sodium symporter activity
GWC92_RS06065	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWC92_RS06070	COG3706	GGDEF domain
GWC92_RS06080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWC92_RS06085	COG1032	radical SAM domain protein
GWC92_RS06090	COG3903	Transcriptional regulator
GWC92_RS06090	COG2319	Wd-40 repeat
GWC92_RS06110	COG0673	inositol 2-dehydrogenase activity
GWC92_RS06115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GWC92_RS06120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GWC92_RS06150	COG0739	heme binding
GWC92_RS06150	COG1196	nuclear chromosome segregation
GWC92_RS06150	COG0741	lytic transglycosylase activity
GWC92_RS06175	COG0788	formyltetrahydrofolate deformylase activity
GWC92_RS06180	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWC92_RS06190	COG3118	belongs to the thioredoxin family
GWC92_RS06200	COG0791	NLP P60 protein
GWC92_RS06205	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GWC92_RS06220	COG1388	LysM domain
GWC92_RS06220	COG1376	ErfK ybiS ycfS ynhG family protein
GWC92_RS06245	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWC92_RS06290	COG1203	CRISPR-associated helicase, Cas3
GWC92_RS06295	COG1518	maintenance of DNA repeat elements
GWC92_RS06330	COG2003	Belongs to the UPF0758 family
GWC92_RS06375	COG3311	Transcriptional regulator
GWC92_RS06390	COG0582	viral genome integration into host DNA
GWC92_RS06395	COG2205	protein histidine kinase activity
GWC92_RS06395	COG0784	Response regulator, receiver
GWC92_RS06420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWC92_RS06420	COG2205	protein histidine kinase activity
GWC92_RS06425	COG3384	dioxygenase
GWC92_RS06435	COG1283	sodium-dependent phosphate transmembrane transporter activity
GWC92_RS06445	COG0531	amino acid
GWC92_RS06450	COG0531	amino acid
GWC92_RS06465	COG1012	belongs to the aldehyde dehydrogenase family
GWC92_RS06470	COG1396	sequence-specific DNA binding
GWC92_RS06470	COG1917	Cupin 2, conserved barrel domain protein
GWC92_RS06475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWC92_RS06520	COG4651	solute:proton antiporter activity
GWC92_RS06520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GWC92_RS06535	COG2974	May be involved in recombination
GWC92_RS06540	COG1247	-acetyltransferase
GWC92_RS06545	COG0420	3'-5' exonuclease activity
GWC92_RS06555	COG3038	cytochrome b561
GWC92_RS06560	COG2190	(PTS) system
GWC92_RS06570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWC92_RS06575	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GWC92_RS06580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWC92_RS06595	COG1720	tRNA m6t6A37 methyltransferase activity
GWC92_RS06615	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GWC92_RS06620	COG4988	ABC transporter
GWC92_RS06635	COG0745	RESPONSE REGULATOR receiver
GWC92_RS06645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GWC92_RS06660	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GWC92_RS06665	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GWC92_RS06675	COG0083	homoserine kinase activity
GWC92_RS06680	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWC92_RS06710	COG1943	Transposase
GWC92_RS06720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWC92_RS06730	COG3220	belongs to the UPF0276 family
GWC92_RS06760	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GWC92_RS06765	COG1289	transmembrane transporter activity
GWC92_RS06770	COG1763	Mo-molybdopterin cofactor biosynthetic process
GWC92_RS06775	COG0746	molybdenum cofactor guanylyltransferase activity
GWC92_RS06780	COG0281	malic enzyme
GWC92_RS06810	COG1196	nuclear chromosome segregation
GWC92_RS06810	COG3264	Mechanosensitive ion channel
GWC92_RS06820	COG2850	peptidyl-arginine hydroxylation
GWC92_RS06825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GWC92_RS06830	COG2915	High frequency lysogenization protein hflD homolog
GWC92_RS06835	COG0482	sulfurtransferase activity
GWC92_RS06845	COG1187	pseudouridine synthase activity
GWC92_RS06850	COG0456	acetyltransferase
GWC92_RS06885	COG0538	isocitrate dehydrogenase activity
GWC92_RS06895	COG3048	D-serine ammonia-lyase activity
GWC92_RS06900	COG0583	DNA-binding transcription factor activity
GWC92_RS06905	COG2916	Histone family protein nucleoid-structuring protein H-NS
GWC92_RS06910	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWC92_RS06915	COG2375	cellular response to nickel ion
GWC92_RS06920	COG1538	Outer membrane efflux protein
GWC92_RS06925	COG0577	efflux transmembrane transporter activity
GWC92_RS06925	COG1136	(ABC) transporter
GWC92_RS06930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWC92_RS06940	COG0497	DNA recombination
GWC92_RS06945	COG3706	GGDEF domain
GWC92_RS06950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GWC92_RS06955	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GWC92_RS06960	COG0443	Heat shock 70 kDa protein
GWC92_RS06965	COG0484	heat shock protein binding
GWC92_RS06995	COG1285	pathogenesis
GWC92_RS07005	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWC92_RS07015	COG0640	Transcriptional regulator
GWC92_RS07045	COG0095	Lipoate-protein ligase
GWC92_RS07060	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWC92_RS07065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWC92_RS07075	COG0708	Exodeoxyribonuclease III
GWC92_RS07085	COG0745	RESPONSE REGULATOR receiver
GWC92_RS07100	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GWC92_RS07115	COG1846	Transcriptional regulator
GWC92_RS07135	COG0583	DNA-binding transcription factor activity
GWC92_RS07140	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWC92_RS07145	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWC92_RS07150	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWC92_RS07155	COG1845	cytochrome c oxidase, subunit III
GWC92_RS07160	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GWC92_RS07165	COG0109	protoheme IX farnesyltransferase activity
GWC92_RS07175	COG2814	Major facilitator Superfamily
GWC92_RS07180	COG5507	3-demethylubiquinone-9 3-methyltransferase
GWC92_RS07190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWC92_RS07195	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GWC92_RS07200	COG4521	taurine ABC transporter
GWC92_RS07230	COG1988	membrane-bound metal-dependent
GWC92_RS07245	COG0159	tryptophan synthase activity
GWC92_RS07250	COG0133	tryptophan synthase activity
GWC92_RS07255	COG0135	phosphoribosylanthranilate isomerase activity
GWC92_RS07255	COG0134	indole-3-glycerol-phosphate synthase activity
GWC92_RS07260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWC92_RS07265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWC92_RS07265	COG0512	Glutamine amidotransferase of anthranilate synthase
GWC92_RS07270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GWC92_RS07275	COG0613	PHP domain protein
GWC92_RS07280	COG0009	L-threonylcarbamoyladenylate synthase
GWC92_RS07290	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GWC92_RS07300	COG1946	Acyl-CoA thioesterase
GWC92_RS07315	COG1309	transcriptional regulator
GWC92_RS07320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWC92_RS07325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWC92_RS07380	COG2003	Belongs to the UPF0758 family
GWC92_RS07395	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GWC92_RS07410	COG0583	DNA-binding transcription factor activity
GWC92_RS07430	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GWC92_RS07440	COG1960	acyl-CoA dehydrogenase activity
GWC92_RS07445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWC92_RS07455	COG0469	pyruvate kinase activity
GWC92_RS07460	COG1737	Transcriptional regulator
GWC92_RS07465	COG0837	glucose binding
GWC92_RS07475	COG0745	RESPONSE REGULATOR receiver
GWC92_RS07485	COG1091	dTDP-4-dehydrorhamnose reductase activity
GWC92_RS07500	COG2801	Transposase and inactivated derivatives
GWC92_RS07525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWC92_RS07605	COG1216	Glycosyl transferase, family 2
GWC92_RS07625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWC92_RS07630	COG0489	protein tyrosine kinase activity
GWC92_RS07630	COG3206	protein involved in exopolysaccharide biosynthesis
GWC92_RS07650	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWC92_RS07660	COG3132	Protein of unknown function, DUF480
GWC92_RS07685	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GWC92_RS07700	COG1278	Cold shock
GWC92_RS07725	COG4166	transmembrane transport
GWC92_RS07730	COG0697	spore germination
GWC92_RS07740	COG0675	Transposase, IS605 OrfB family
GWC92_RS07745	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GWC92_RS07760	COG4166	transmembrane transport
GWC92_RS07765	COG0622	Phosphoesterase
GWC92_RS07780	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
GWC92_RS07785	COG0835	chemotaxis
GWC92_RS07785	COG0784	Response regulator, receiver
GWC92_RS07790	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GWC92_RS07795	COG1815	bacterial-type flagellum-dependent cell motility
GWC92_RS07810	COG1749	Flagellar hook protein flgE
GWC92_RS07825	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GWC92_RS07830	COG1706	bacterial-type flagellum-dependent cell motility
GWC92_RS07835	COG1705	Flagellar rod assembly protein muramidase FlgJ
GWC92_RS07835	COG3951	Flagellar rod assembly protein muramidase FlgJ
GWC92_RS07850	COG2239	Acts as a magnesium transporter
GWC92_RS07860	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GWC92_RS07865	COG2716	regulation of RNA biosynthetic process
GWC92_RS07880	COG3852	Histidine kinase
GWC92_RS07890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GWC92_RS07895	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GWC92_RS07900	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GWC92_RS07905	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GWC92_RS07925	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GWC92_RS07940	COG0590	tRNA wobble adenosine to inosine editing
GWC92_RS07945	COG0573	inorganic phosphate transmembrane transporter activity
GWC92_RS07950	COG0581	inorganic phosphate transmembrane transporter activity
GWC92_RS07960	COG0704	Plays a role in the regulation of phosphate uptake
GWC92_RS07965	COG1253	flavin adenine dinucleotide binding
GWC92_RS07980	COG0531	amino acid
GWC92_RS07995	COG1126	abc transporter atp-binding protein
GWC92_RS08000	COG0765	amino acid transport
GWC92_RS08005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWC92_RS08010	COG3706	GGDEF domain
GWC92_RS08015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWC92_RS08035	COG1785	Belongs to the alkaline phosphatase family
GWC92_RS08040	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GWC92_RS08045	COG0477	Major facilitator Superfamily
GWC92_RS08050	COG0123	including yeast histone deacetylase and acetoin utilization protein
GWC92_RS08060	COG1199	ATP-dependent helicase activity
GWC92_RS08075	COG1448	Aminotransferase
GWC92_RS08080	COG0433	COG0433 Predicted ATPase
GWC92_RS08095	COG0658	competence protein
GWC92_RS08095	COG2333	competence protein COMEC
GWC92_RS08100	COG1132	(ABC) transporter
GWC92_RS08105	COG1663	tetraacyldisaccharide 4'-kinase activity
GWC92_RS08110	COG2835	tetraacyldisaccharide 4'-kinase activity
GWC92_RS08115	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GWC92_RS08120	COG2197	response regulator
GWC92_RS08125	COG0322	excinuclease ABC activity
GWC92_RS08150	COG0583	DNA-binding transcription factor activity
GWC92_RS08165	COG0604	alcohol dehydrogenase
GWC92_RS08170	COG1309	transcriptional regulator
GWC92_RS08175	COG2261	transglycosylase associated protein
GWC92_RS08180	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWC92_RS08190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GWC92_RS08195	COG0215	cysteine-tRNA ligase activity
GWC92_RS08215	COG2199	diguanylate cyclase activity
GWC92_RS08215	COG2203	Gaf domain
GWC92_RS08250	COG2119	membrane
GWC92_RS08255	COG0023	Translation Initiation Factor
GWC92_RS08265	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GWC92_RS08290	COG4139	cobalamin transport
GWC92_RS08295	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GWC92_RS08300	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWC92_RS08305	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GWC92_RS08310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWC92_RS08315	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GWC92_RS08320	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GWC92_RS08330	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GWC92_RS08335	COG0505	Belongs to the CarA family
GWC92_RS08340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GWC92_RS08345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWC92_RS08350	COG3706	GGDEF domain
GWC92_RS08380	COG0513	Belongs to the DEAD box helicase family
GWC92_RS08390	COG4104	PAAR repeat-containing protein
GWC92_RS08415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWC92_RS08420	COG0765	amino acid transport
GWC92_RS08430	COG0493	'glutamate synthase
GWC92_RS08435	COG0070	glutamate synthase
GWC92_RS08435	COG0069	glutamate synthase activity
GWC92_RS08435	COG0067	glutamate synthase
GWC92_RS08440	COG1242	4 iron, 4 sulfur cluster binding
GWC92_RS08485	COG1113	amino acid transport
GWC92_RS08495	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GWC92_RS08500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWC92_RS08500	COG0574	Belongs to the PEP-utilizing enzyme family
GWC92_RS08505	COG1119	ATPase activity
GWC92_RS08525	COG1464	Belongs to the NlpA lipoprotein family
GWC92_RS08535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWC92_RS08540	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GWC92_RS08550	COG0101	tRNA pseudouridine synthase activity
GWC92_RS08555	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GWC92_RS08560	COG0285	dihydrofolate synthase activity
GWC92_RS08565	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GWC92_RS08570	COG2920	part of a sulfur-relay system
GWC92_RS08575	COG1289	transmembrane transporter activity
GWC92_RS08580	COG0670	Belongs to the BI1 family
GWC92_RS08620	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GWC92_RS08625	COG0840	transmembrane signaling receptor activity
GWC92_RS08630	COG5001	Diguanylate cyclase
GWC92_RS08635	COG0564	pseudouridine synthase activity
GWC92_RS08650	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GWC92_RS08660	COG0625	glutathione transferase activity
GWC92_RS08675	COG0367	asparagine synthase
GWC92_RS08685	COG0647	UMP catabolic process
GWC92_RS08690	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GWC92_RS08695	COG0604	alcohol dehydrogenase
GWC92_RS08700	COG1902	pentaerythritol trinitrate reductase activity
GWC92_RS08705	COG1253	flavin adenine dinucleotide binding
GWC92_RS08715	COG0277	FAD linked oxidase domain protein
GWC92_RS08715	COG0247	lactate metabolic process
GWC92_RS08725	COG2050	protein possibly involved in aromatic compounds catabolism
GWC92_RS08740	COG5001	Diguanylate cyclase
GWC92_RS08745	COG0583	DNA-binding transcription factor activity
GWC92_RS08750	COG2814	Major facilitator Superfamily
GWC92_RS08755	COG2056	Na+-H+ antiporter family
GWC92_RS08760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWC92_RS08775	COG0483	inositol monophosphate 1-phosphatase activity
GWC92_RS08785	COG0625	glutathione transferase activity
GWC92_RS08790	COG0625	glutathione transferase activity
GWC92_RS08800	COG0601	transmembrane transport
GWC92_RS08805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWC92_RS08810	COG0444	Belongs to the ABC transporter superfamily
GWC92_RS08815	COG2814	Major facilitator Superfamily
GWC92_RS08835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWC92_RS08840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWC92_RS08845	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GWC92_RS08850	COG0509	glycine decarboxylation via glycine cleavage system
GWC92_RS08855	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWC92_RS08855	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWC92_RS08880	COG3634	alkyl hydroperoxide reductase activity
GWC92_RS08885	COG0450	alkyl hydroperoxide reductase
GWC92_RS08890	COG0517	IMP dehydrogenase activity
GWC92_RS08895	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GWC92_RS08900	COG0343	queuine tRNA-ribosyltransferase activity
GWC92_RS08905	COG1862	Preprotein translocase
GWC92_RS08910	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWC92_RS08915	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWC92_RS08920	COG2897	thiosulfate sulfurtransferase activity
GWC92_RS08930	COG0826	peptidase U32
GWC92_RS08935	COG0826	peptidase U32
GWC92_RS08940	COG3154	lipid carrier protein
GWC92_RS08955	COG1104	cysteine desulfurase activity
GWC92_RS08960	COG0822	iron-sulfur transferase activity
GWC92_RS08970	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GWC92_RS08975	COG0443	Heat shock 70 kDa protein
GWC92_RS08980	COG0633	Ferredoxin
GWC92_RS08990	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GWC92_RS08995	COG0105	UTP biosynthetic process
GWC92_RS09000	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GWC92_RS09010	COG1426	Protein conserved in bacteria
GWC92_RS09020	COG0124	histidyl-tRNA synthetase
GWC92_RS09025	COG2976	Protein conserved in bacteria
GWC92_RS09030	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWC92_RS09035	COG1160	GTP binding
GWC92_RS09040	COG1645	bacterial-type flagellum-dependent swarming motility
GWC92_RS09045	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GWC92_RS09050	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GWC92_RS09050	COG0047	phosphoribosylformylglycinamidine synthase activity
GWC92_RS09055	COG1007	ATP synthesis coupled electron transport
GWC92_RS09060	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWC92_RS09070	COG0713	ATP synthesis coupled electron transport
GWC92_RS09075	COG0839	Belongs to the complex I subunit 6 family
GWC92_RS09080	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWC92_RS09085	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GWC92_RS09090	COG1034	ATP synthesis coupled electron transport
GWC92_RS09105	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWC92_RS09105	COG0649	NAD binding
GWC92_RS09110	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWC92_RS09115	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWC92_RS09120	COG1360	Flagellar Motor Protein
GWC92_RS09125	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWC92_RS09140	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GWC92_RS09150	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
GWC92_RS09160	COG0724	RNA recognition motif
GWC92_RS09165	COG4989	oxidoreductase activity
GWC92_RS09190	COG0745	RESPONSE REGULATOR receiver
GWC92_RS09195	COG0583	DNA-binding transcription factor activity
GWC92_RS09205	COG3300	MHYT domain
GWC92_RS09205	COG5001	Diguanylate cyclase
GWC92_RS09210	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GWC92_RS09240	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWC92_RS09245	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GWC92_RS09250	COG0539	negative regulation of cytoplasmic translation
GWC92_RS09255	COG0776	regulation of translation
GWC92_RS09265	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GWC92_RS09285	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GWC92_RS09290	COG0602	queuosine metabolic process
GWC92_RS09295	COG3530	Putative quorum-sensing-regulated virulence factor
GWC92_RS09300	COG2096	Adenosyltransferase
GWC92_RS09305	COG2916	Histone family protein nucleoid-structuring protein H-NS
GWC92_RS09310	COG1757	Na H antiporter
GWC92_RS09315	COG1435	thymidine kinase activity
GWC92_RS09350	COG1349	DNA-binding transcription factor activity
GWC92_RS09355	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GWC92_RS09375	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GWC92_RS09380	COG0626	cystathionine gamma-synthase activity
GWC92_RS09390	COG2910	NAD(P)H-binding
GWC92_RS09395	COG0583	DNA-binding transcription factor activity
GWC92_RS09400	COG4977	sequence-specific DNA binding
GWC92_RS09400	COG1917	Cupin 2, conserved barrel domain protein
GWC92_RS09405	COG2200	EAL domain
GWC92_RS09410	COG3706	GGDEF domain
GWC92_RS09415	COG4774	siderophore transport
GWC92_RS09425	COG0583	DNA-binding transcription factor activity
GWC92_RS09430	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GWC92_RS09440	COG0517	IMP dehydrogenase activity
GWC92_RS09440	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GWC92_RS09440	COG0617	tRNA 3'-terminal CCA addition
GWC92_RS09445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWC92_RS09450	COG3046	protein related to deoxyribodipyrimidine photolyase
GWC92_RS09465	COG3088	subunit of a heme lyase
GWC92_RS09465	COG4235	cytochrome complex assembly
GWC92_RS09470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWC92_RS09475	COG1138	Cytochrome C-type biogenesis protein
GWC92_RS09480	COG3301	Polysulphide reductase, NrfD
GWC92_RS09485	COG0437	4 iron, 4 sulfur cluster binding
GWC92_RS09490	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GWC92_RS09510	COG0247	lactate metabolic process
GWC92_RS09520	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GWC92_RS09525	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GWC92_RS09530	COG3012	SEC-C Motif Domain Protein
GWC92_RS09535	COG0840	transmembrane signaling receptor activity
GWC92_RS09540	COG1846	Transcriptional regulator
GWC92_RS09540	COG1940	carbohydrate kinase activity
GWC92_RS09545	COG3290	protein histidine kinase activity
GWC92_RS09550	COG4565	transcriptional regulatory protein
GWC92_RS09565	COG3181	Tripartite tricarboxylate transporter family receptor
GWC92_RS09570	COG0739	heme binding
GWC92_RS09570	COG0741	lytic transglycosylase activity
GWC92_RS09570	COG1196	nuclear chromosome segregation
GWC92_RS09575	COG2985	domain, Protein
GWC92_RS09575	COG0569	domain protein
GWC92_RS09585	COG0556	nucleotide-excision repair
GWC92_RS09595	COG0586	Pfam SNARE associated Golgi protein
GWC92_RS09600	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GWC92_RS09605	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GWC92_RS09610	COG2186	Transcriptional regulator
GWC92_RS09615	COG2719	SpoVR family
GWC92_RS09620	COG2718	Belongs to the UPF0229 family
GWC92_RS09625	COG2766	serine protein kinase
GWC92_RS09630	COG0514	ATP-dependent DNA helicase (RecQ)
GWC92_RS09635	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GWC92_RS09640	COG0814	amino acid
GWC92_RS09670	COG0058	SHG alpha-glucan phosphorylase activity
GWC92_RS09680	COG0471	metal ion transport
GWC92_RS09685	COG3118	belongs to the thioredoxin family
GWC92_RS09695	COG1132	(ABC) transporter
GWC92_RS09700	COG1132	(ABC) transporter
GWC92_RS09715	COG2501	S4 domain
GWC92_RS09725	COG3243	poly(R)-hydroxyalkanoic acid synthase
GWC92_RS09745	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GWC92_RS09750	COG2329	Antibiotic biosynthesis monooxygenase
GWC92_RS09785	COG0513	Belongs to the DEAD box helicase family
GWC92_RS09790	COG0386	Belongs to the glutathione peroxidase family
GWC92_RS09800	COG1181	Belongs to the D-alanine--D-alanine ligase family
GWC92_RS09810	COG0730	response to heat
GWC92_RS09815	COG0583	DNA-binding transcription factor activity
GWC92_RS09830	COG3593	DNA synthesis involved in DNA repair
GWC92_RS09870	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GWC92_RS09875	COG1011	Hydrolase
GWC92_RS09880	COG1473	amidohydrolase
GWC92_RS09885	COG0205	6-phosphofructokinase activity
GWC92_RS09895	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GWC92_RS09900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWC92_RS09910	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GWC92_RS09915	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GWC92_RS09945	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GWC92_RS09950	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWC92_RS09965	COG0588	phosphoglycerate mutase activity
GWC92_RS09980	COG1280	lysine exporter protein (LysE YggA)
GWC92_RS09990	COG2824	Alkylphosphonate utilization operon protein PhnA
GWC92_RS10025	COG2840	Smr protein MutS2
GWC92_RS10030	COG2890	protein-(glutamine-N5) methyltransferase activity
GWC92_RS10035	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GWC92_RS10045	COG0513	Belongs to the DEAD box helicase family
GWC92_RS10050	COG5654	RES domain protein
GWC92_RS10060	COG0814	amino acid
GWC92_RS10065	COG1609	Transcriptional regulator
GWC92_RS10070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWC92_RS10070	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWC92_RS10075	COG1105	Belongs to the carbohydrate kinase PfkB family
GWC92_RS10080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWC92_RS10080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWC92_RS10080	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GWC92_RS10085	COG3313	Fe-S protein
GWC92_RS10090	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GWC92_RS10095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWC92_RS10100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWC92_RS10105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWC92_RS10115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWC92_RS10145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GWC92_RS10150	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GWC92_RS10155	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GWC92_RS10160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GWC92_RS10165	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GWC92_RS10170	COG0072	phenylalanine-tRNA ligase activity
GWC92_RS10170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWC92_RS10175	COG0776	regulation of translation
GWC92_RS10205	COG5001	Diguanylate cyclase
GWC92_RS10205	COG3300	MHYT domain
GWC92_RS10210	COG1609	Transcriptional regulator
GWC92_RS10215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWC92_RS10220	COG1879	ABC-type sugar transport system periplasmic component
GWC92_RS10225	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWC92_RS10230	COG1129	ABC transporter
GWC92_RS10235	COG1869	D-ribose catabolic process
GWC92_RS10240	COG0625	glutathione transferase activity
GWC92_RS10255	COG0037	tRNA processing
GWC92_RS10260	COG0589	response to stress
GWC92_RS10265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWC92_RS10280	COG2217	Heavy metal translocating P-type atpase
GWC92_RS10290	COG2010	Cytochrome c
GWC92_RS10305	COG3278	Belongs to the heme-copper respiratory oxidase family
GWC92_RS10315	COG1956	GAF domain-containing protein
GWC92_RS10320	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GWC92_RS10330	COG0308	aminopeptidase N
GWC92_RS10340	COG2902	Dehydrogenase
GWC92_RS10345	COG0167	dihydroorotate dehydrogenase activity
GWC92_RS10355	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GWC92_RS10355	COG0116	Belongs to the methyltransferase superfamily
GWC92_RS10380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWC92_RS10385	COG1067	ATP-dependent peptidase activity
GWC92_RS10395	COG3141	response to X-ray
GWC92_RS10405	COG2995	paraquat-inducible protein a
GWC92_RS10410	COG3008	intermembrane lipid transfer
GWC92_RS10415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWC92_RS10415	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GWC92_RS10450	COG0084	hydrolase, TatD family'
GWC92_RS10455	COG0470	DNA polymerase III
GWC92_RS10460	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GWC92_RS10465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GWC92_RS10470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GWC92_RS10475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWC92_RS10480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWC92_RS10485	COG1028	Short-chain dehydrogenase reductase Sdr
GWC92_RS10495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWC92_RS10500	COG0416	fatty acid biosynthetic process
GWC92_RS10505	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GWC92_RS10510	COG1399	metal-binding, possibly nucleic acid-binding protein
GWC92_RS10525	COG0564	pseudouridine synthase activity
GWC92_RS10530	COG1530	ribonuclease E activity
GWC92_RS10535	COG0306	phosphate transporter
GWC92_RS10540	COG0717	Belongs to the dCTP deaminase family
GWC92_RS10545	COG0572	uridine kinase
GWC92_RS10550	COG0489	protein tyrosine kinase activity
GWC92_RS10555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWC92_RS10555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWC92_RS10560	COG0625	glutathione transferase activity
GWC92_RS10565	COG1254	Belongs to the acylphosphatase family
GWC92_RS10570	COG0840	transmembrane signaling receptor activity
GWC92_RS10575	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GWC92_RS10590	COG0709	Synthesizes selenophosphate from selenide and ATP
GWC92_RS10595	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GWC92_RS10600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWC92_RS10605	COG3437	response regulator, receiver
GWC92_RS10615	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GWC92_RS10625	COG1643	Atp-dependent helicase
GWC92_RS10630	COG0617	tRNA 3'-terminal CCA addition
GWC92_RS10630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GWC92_RS10630	COG0517	IMP dehydrogenase activity
GWC92_RS10635	COG2197	response regulator
GWC92_RS10650	COG0583	DNA-binding transcription factor activity
GWC92_RS10655	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GWC92_RS10665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GWC92_RS10670	COG2832	Protein of unknown function (DUF454)
GWC92_RS10675	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWC92_RS10685	COG0697	spore germination
GWC92_RS10700	COG0318	PFAM AMP-dependent synthetase and ligase
GWC92_RS10705	COG0596	Alpha beta hydrolase
GWC92_RS10715	COG1214	PFAM Peptidase M22, glycoprotease
GWC92_RS10720	COG1199	ATP-dependent helicase activity
GWC92_RS10730	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GWC92_RS10735	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GWC92_RS10740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GWC92_RS10745	COG0131	Imidazoleglycerol-phosphate dehydratase
GWC92_RS10745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GWC92_RS10750	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GWC92_RS10755	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GWC92_RS10760	COG3437	response regulator, receiver
GWC92_RS10770	COG2205	protein histidine kinase activity
GWC92_RS10770	COG2198	Histidine kinase
GWC92_RS10770	COG0784	Response regulator, receiver
GWC92_RS10775	COG0107	imidazoleglycerol-phosphate synthase activity
GWC92_RS10780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GWC92_RS10780	COG0140	phosphoribosyl-ATP diphosphatase activity
GWC92_RS10790	COG2378	regulation of single-species biofilm formation
GWC92_RS10795	COG0318	PFAM AMP-dependent synthetase and ligase
GWC92_RS10800	COG3134	Outer membrane lipoprotein
GWC92_RS10815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWC92_RS10840	COG4681	YaeQ
GWC92_RS10850	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWC92_RS10850	COG1024	Enoyl-CoA hydratase
GWC92_RS10855	COG0183	Belongs to the thiolase family
GWC92_RS10860	COG0714	Associated with various cellular activities
GWC92_RS10890	COG1595	DNA-templated transcription, initiation
GWC92_RS10900	COG2067	long-chain fatty acid transport protein
GWC92_RS10905	COG2067	long-chain fatty acid transport protein
GWC92_RS10910	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GWC92_RS10925	COG1301	dicarboxylic acid transport
GWC92_RS10930	COG3123	guanosine phosphorylase activity
GWC92_RS10935	COG1760	l-serine dehydratase
GWC92_RS10940	COG1760	l-serine dehydratase
GWC92_RS10945	COG2951	lytic endotransglycosylase activity
GWC92_RS10950	COG3100	YcgL domain-containing protein
GWC92_RS10955	COG0850	regulation of cytokinetic process
GWC92_RS10960	COG2894	cell division
GWC92_RS10965	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GWC92_RS10970	COG3099	Belongs to the UPF0263 family
GWC92_RS10975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWC92_RS10990	COG2996	Protein conserved in bacteria
GWC92_RS11015	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GWC92_RS11020	COG0697	spore germination
GWC92_RS11025	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GWC92_RS11030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWC92_RS11045	COG0307	riboflavin synthase, alpha
GWC92_RS11055	COG0534	Mate efflux family protein
GWC92_RS11085	COG0417	DNA replication proofreading
GWC92_RS11100	COG1560	Kdo2-lipid A biosynthetic process
GWC92_RS11105	COG1560	Kdo2-lipid A biosynthetic process
GWC92_RS11115	COG0583	DNA-binding transcription factor activity
GWC92_RS11120	COG0673	inositol 2-dehydrogenase activity
GWC92_RS11125	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GWC92_RS11145	COG0583	DNA-binding transcription factor activity
GWC92_RS11155	COG2723	6-phospho-beta-galactosidase activity
GWC92_RS11160	COG0583	DNA-binding transcription factor activity
GWC92_RS11170	COG0243	molybdopterin cofactor binding
GWC92_RS11175	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GWC92_RS11190	COG0583	DNA-binding transcription factor activity
GWC92_RS11195	COG1879	ABC-type sugar transport system periplasmic component
GWC92_RS11200	COG1129	ABC transporter
GWC92_RS11205	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWC92_RS11210	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWC92_RS11225	COG0702	epimerase
GWC92_RS11230	COG1073	alpha beta
GWC92_RS11235	COG1073	alpha beta
GWC92_RS11285	COG0730	response to heat
GWC92_RS11295	COG1028	Short-chain dehydrogenase reductase Sdr
GWC92_RS11305	COG1024	Enoyl-CoA hydratase
GWC92_RS11310	COG1024	Enoyl-CoA hydratase
GWC92_RS11315	COG1960	acyl-CoA dehydrogenase activity
GWC92_RS11325	COG1960	acyl-CoA dehydrogenase activity
GWC92_RS11330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWC92_RS11335	COG1024	Enoyl-CoA hydratase
GWC92_RS11360	COG1584	GPR1 FUN34 yaaH family protein
GWC92_RS11365	COG3228	Belongs to the MtfA family
GWC92_RS11375	COG1115	amino acid carrier protein
GWC92_RS11380	COG1024	Enoyl-CoA hydratase
GWC92_RS11395	COG3162	membrane
GWC92_RS11400	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWC92_RS11405	COG0488	(ABC) transporter
GWC92_RS11410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWC92_RS11415	COG0776	regulation of translation
GWC92_RS11420	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GWC92_RS11425	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GWC92_RS11430	COG0740	serine-type endopeptidase activity
GWC92_RS11435	COG0544	peptidyl-prolyl cis-trans isomerase activity
GWC92_RS11445	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GWC92_RS11450	COG4591	ABC-type transport system involved in lipoprotein release permease component
GWC92_RS11455	COG1136	(ABC) transporter
GWC92_RS11460	COG4591	ABC-type transport system involved in lipoprotein release permease component
GWC92_RS11470	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GWC92_RS11475	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GWC92_RS11500	COG2062	phosphohistidine phosphatase, SixA
GWC92_RS11510	COG0500	methyltransferase
GWC92_RS11520	COG1846	Transcriptional regulator
GWC92_RS11585	COG0789	Transcriptional regulator
GWC92_RS11665	COG0582	viral genome integration into host DNA
GWC92_RS11670	COG0519	Catalyzes the synthesis of GMP from XMP
GWC92_RS11670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWC92_RS11675	COG0517	IMP dehydrogenase activity
GWC92_RS11675	COG0516	GMP reductase activity
GWC92_RS11685	COG1874	Beta-galactosidase
GWC92_RS11685	COG0366	Alpha amylase catalytic
GWC92_RS11695	COG1570	exodeoxyribonuclease VII activity
GWC92_RS11705	COG2885	chlorophyll binding
GWC92_RS11725	COG2154	pterin-4-alpha-carbinolamine dehydratase
GWC92_RS11735	COG3768	UPF0283 membrane protein
GWC92_RS11740	COG3106	COG3106 Predicted ATPase
GWC92_RS11755	COG1842	Phage shock protein A
GWC92_RS11760	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GWC92_RS11775	COG4171	peptide transport system, permease
GWC92_RS11785	COG4172	Belongs to the ABC transporter superfamily
GWC92_RS11795	COG1609	Transcriptional regulator
GWC92_RS11800	COG1263	PTS System
GWC92_RS11800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWC92_RS11805	COG2723	6-phospho-beta-galactosidase activity
GWC92_RS11810	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GWC92_RS11815	COG1286	toxin biosynthetic process
GWC92_RS11820	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GWC92_RS11825	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GWC92_RS11830	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWC92_RS11835	COG1674	ftsk spoiiie
GWC92_RS11835	COG0531	amino acid
GWC92_RS11845	COG0686	Belongs to the AlaDH PNT family
GWC92_RS11850	COG0492	ferredoxin-NADP+ reductase activity
GWC92_RS11855	COG3706	GGDEF domain
GWC92_RS11860	COG3134	Outer membrane lipoprotein
GWC92_RS11865	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GWC92_RS11870	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GWC92_RS11875	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GWC92_RS11880	COG0542	response to heat
GWC92_RS11885	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GWC92_RS11890	COG1278	Cold shock
GWC92_RS11895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GWC92_RS11910	COG1944	ATP diphosphatase activity
GWC92_RS11915	COG2116	formate transmembrane transporter activity
GWC92_RS11920	COG1882	Formate acetyltransferase
GWC92_RS11925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWC92_RS11935	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GWC92_RS11945	COG1840	ABC-type Fe3 transport system, periplasmic component
GWC92_RS11950	COG3842	ATPase activity
GWC92_RS11960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWC92_RS11965	COG2983	Belongs to the UPF0260 family
GWC92_RS11980	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GWC92_RS11985	COG0045	succinate-CoA ligase (ADP-forming) activity
GWC92_RS11990	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWC92_RS11995	COG0567	Dehydrogenase, E1 component
GWC92_RS12010	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GWC92_RS12015	COG2009	succinate dehydrogenase
GWC92_RS12035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWC92_RS12040	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GWC92_RS12040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWC92_RS12050	COG3069	C4-dicarboxylate transmembrane transporter activity
GWC92_RS12065	COG1451	nucleotide metabolic process
GWC92_RS12080	COG0254	rRNA binding
GWC92_RS12085	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWC92_RS12095	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWC92_RS12100	COG1129	ABC transporter
GWC92_RS12105	COG1879	ABC-type sugar transport system periplasmic component
GWC92_RS12110	COG1069	ribulokinase activity
GWC92_RS12120	COG2160	L-arabinose isomerase activity
GWC92_RS12125	COG0583	DNA-binding transcription factor activity
GWC92_RS12130	COG0436	Aminotransferase
GWC92_RS12135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWC92_RS12150	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GWC92_RS12150	COG0392	lysyltransferase activity
GWC92_RS12175	COG1263	PTS System
GWC92_RS12175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWC92_RS12180	COG1874	Beta-galactosidase
GWC92_RS12185	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GWC92_RS12190	COG3833	ABC-type maltose transport systems, permease component
GWC92_RS12195	COG1175	transmembrane transport
GWC92_RS12200	COG2182	Extracellular solute-binding protein
GWC92_RS12225	COG4580	involved in the transport of maltose and maltodextrins
GWC92_RS12230	COG1609	Transcriptional regulator
GWC92_RS12235	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWC92_RS12240	COG1085	galactose-1-phosphate uridylyltransferase
GWC92_RS12245	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWC92_RS12280	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GWC92_RS12295	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GWC92_RS12325	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GWC92_RS12345	COG2925	Exonuclease
GWC92_RS12355	COG3345	alpha-galactosidase
GWC92_RS12360	COG1380	Effector of murein hydrolase LrgA
GWC92_RS12365	COG1346	cytolysis
GWC92_RS12370	COG0295	cytidine deaminase activity
GWC92_RS12375	COG1022	Amp-dependent synthetase and ligase
GWC92_RS12390	COG0861	Integral membrane protein TerC family
GWC92_RS12395	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWC92_RS12400	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GWC92_RS12405	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GWC92_RS12445	COG4771	TonB-dependent receptor
GWC92_RS12450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWC92_RS12455	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWC92_RS12460	COG1120	ATPase activity
GWC92_RS12475	COG3321	synthase
GWC92_RS12475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWC92_RS12475	COG1028	Short-chain dehydrogenase reductase Sdr
GWC92_RS12475	COG0318	PFAM AMP-dependent synthetase and ligase
GWC92_RS12475	COG0300	oxidoreductase activity
GWC92_RS12485	COG1028	Short-chain dehydrogenase reductase Sdr
GWC92_RS12490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWC92_RS12495	COG1535	isochorismatase
GWC92_RS12495	COG3433	isochorismatase activity
GWC92_RS12500	COG1021	2,3-dihydroxybenzoate-AMP ligase
GWC92_RS12525	COG5001	Diguanylate cyclase
GWC92_RS12525	COG3300	MHYT domain
GWC92_RS12540	COG0840	transmembrane signaling receptor activity
GWC92_RS12545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWC92_RS12550	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GWC92_RS12555	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GWC92_RS12560	COG0563	adenylate kinase activity
GWC92_RS12565	COG0326	Molecular chaperone. Has ATPase activity
GWC92_RS12570	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GWC92_RS12575	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GWC92_RS12580	COG0298	carbon dioxide binding
GWC92_RS12590	COG0309	Hydrogenase expression formation protein (HypE)
GWC92_RS12595	COG0375	protein maturation
GWC92_RS12600	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GWC92_RS12605	COG1124	(ABC) transporter
GWC92_RS12610	COG0444	Belongs to the ABC transporter superfamily
GWC92_RS12615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWC92_RS12630	COG1773	rubredoxin
GWC92_RS12635	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GWC92_RS12640	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GWC92_RS12645	COG5557	Pfam Polysulphide reductase, NrfD
GWC92_RS12650	COG0437	4 iron, 4 sulfur cluster binding
GWC92_RS12655	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GWC92_RS12660	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWC92_RS12670	COG0659	secondary active sulfate transmembrane transporter activity
GWC92_RS12690	COG2308	Evidence 4 Homologs of previously reported genes of
GWC92_RS12725	COG0672	)-iron permease
GWC92_RS12750	COG2814	Major facilitator Superfamily
GWC92_RS12770	COG1136	(ABC) transporter
GWC92_RS12805	COG1139	Iron-sulfur cluster binding protein
GWC92_RS12810	COG0247	lactate metabolic process
GWC92_RS12815	COG1620	l-lactate permease
GWC92_RS12820	COG0583	DNA-binding transcription factor activity
GWC92_RS12845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWC92_RS12850	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GWC92_RS12850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWC92_RS12855	COG0527	aspartate kinase activity
GWC92_RS12865	COG1368	sulfuric ester hydrolase activity
GWC92_RS12870	COG0393	Putative heavy-metal-binding
GWC92_RS12880	COG1252	NADH dehydrogenase
GWC92_RS12885	COG3150	esterase
GWC92_RS12890	COG1164	Oligoendopeptidase f
GWC92_RS12895	COG1164	Oligoendopeptidase f
GWC92_RS12900	COG2354	Protein conserved in bacteria
GWC92_RS12915	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWC92_RS12920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWC92_RS12955	COG0537	adenosine 5'-monophosphoramidase activity
GWC92_RS12970	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GWC92_RS12990	COG1301	dicarboxylic acid transport
GWC92_RS13000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWC92_RS13005	COG0861	Integral membrane protein TerC family
GWC92_RS13015	COG0444	Belongs to the ABC transporter superfamily
GWC92_RS13020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWC92_RS13025	COG0601	transmembrane transport
GWC92_RS13035	COG2095	MarC family integral membrane protein
GWC92_RS13040	COG1012	belongs to the aldehyde dehydrogenase family
GWC92_RS13040	COG1454	alcohol dehydrogenase
GWC92_RS13050	COG3275	phosphorelay sensor kinase activity
GWC92_RS13055	COG3279	Response regulator of the LytR AlgR family
GWC92_RS13060	COG1966	Carbon starvation protein
GWC92_RS13065	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GWC92_RS13065	COG3264	Mechanosensitive ion channel
GWC92_RS13075	COG1566	PFAM secretion protein HlyD family protein
GWC92_RS13080	COG1061	Type III restriction enzyme res subunit
GWC92_RS13085	COG2027	D-alanyl-D-alanine carboxypeptidase
GWC92_RS13090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GWC92_RS13100	COG0436	Aminotransferase
GWC92_RS13105	COG1288	antiporter activity
GWC92_RS13110	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GWC92_RS13185	COG4397	Mu-like prophage major head subunit gpT
GWC92_RS13190	COG4388	Caudovirus prohead serine protease
GWC92_RS13210	COG4383	Mu-like prophage protein gp29
GWC92_RS13215	COG4373	Mu-like prophage FluMu protein gp28
GWC92_RS13225	COG0640	Transcriptional regulator
GWC92_RS13330	COG2932	Transcriptional regulator
GWC92_RS13350	COG0697	spore germination
GWC92_RS13355	COG4657	Part of a membrane complex involved in electron transport
GWC92_RS13360	COG2878	Part of a membrane complex involved in electron transport
GWC92_RS13370	COG4658	electron transport chain
GWC92_RS13375	COG4659	FMN binding
GWC92_RS13380	COG4660	Part of a membrane complex involved in electron transport
GWC92_RS13385	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GWC92_RS13390	COG0346	lactoylglutathione lyase activity
GWC92_RS13415	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GWC92_RS13425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWC92_RS13430	COG1086	Polysaccharide biosynthesis protein
GWC92_RS13435	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GWC92_RS13445	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
GWC92_RS13450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWC92_RS13465	COG2089	acid synthase
GWC92_RS13505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWC92_RS13525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWC92_RS13525	COG0301	tRNA thio-modification
GWC92_RS13535	COG4953	penicillin-binding protein 1C
GWC92_RS13540	COG2373	Large extracellular alpha-helical protein
GWC92_RS13545	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWC92_RS13555	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GWC92_RS13565	COG4160	amino acid transport
GWC92_RS13575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWC92_RS13585	COG2431	L-lysine efflux transmembrane transporter activity
GWC92_RS13590	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWC92_RS13595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWC92_RS13620	COG1393	Belongs to the ArsC family
GWC92_RS13630	COG4783	chaperone-mediated protein folding
GWC92_RS13635	COG0425	Belongs to the sulfur carrier protein TusA family
GWC92_RS13650	COG0596	Alpha beta hydrolase
GWC92_RS13660	COG3842	ATPase activity
GWC92_RS13665	COG3833	ABC-type maltose transport systems, permease component
GWC92_RS13670	COG1175	transmembrane transport
GWC92_RS13680	COG3081	Nucleoid-associated protein
GWC92_RS13685	COG3082	Protein of unknown function (DUF1414)
GWC92_RS13690	COG3083	sulfuric ester hydrolase activity
GWC92_RS13695	COG4771	TonB-dependent receptor
GWC92_RS13700	COG1770	oligopeptidase
GWC92_RS13720	COG4574	serine-type endopeptidase inhibitor activity
GWC92_RS13725	COG3085	chromosome segregation
GWC92_RS13735	COG1605	Chorismate mutase
GWC92_RS13735	COG0287	Prephenate dehydrogenase
GWC92_RS13740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWC92_RS13745	COG0584	glycerophosphoryl diester phosphodiesterase
GWC92_RS13755	COG1349	DNA-binding transcription factor activity
GWC92_RS13760	COG2271	Major facilitator Superfamily
GWC92_RS13765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GWC92_RS13770	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GWC92_RS13775	COG0583	DNA-binding transcription factor activity
GWC92_RS13795	COG0656	L-ascorbic acid biosynthetic process
GWC92_RS13800	COG2814	Major facilitator Superfamily
GWC92_RS13820	COG1294	oxidase, subunit
GWC92_RS13830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWC92_RS13840	COG2979	Protein of unknown function (DUF533)
GWC92_RS13860	COG0583	DNA-binding transcription factor activity
GWC92_RS13870	COG2807	transmembrane transport
GWC92_RS13875	COG1187	pseudouridine synthase activity
GWC92_RS13880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWC92_RS13905	COG1061	Type III restriction enzyme res subunit
GWC92_RS13930	COG1166	arginine decarboxylase activity
GWC92_RS13935	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWC92_RS13950	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GWC92_RS13965	COG0583	DNA-binding transcription factor activity
GWC92_RS13975	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GWC92_RS13980	COG0840	transmembrane signaling receptor activity
GWC92_RS13985	COG0302	gtp cyclohydrolase
GWC92_RS13995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWC92_RS14010	COG2267	carboxylic ester hydrolase activity
GWC92_RS14015	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GWC92_RS14030	COG0314	molybdopterin synthase activity
GWC92_RS14035	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GWC92_RS14040	COG0315	cyclic pyranopterin monophosphate synthase activity
GWC92_RS14045	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWC92_RS14050	COG3005	denitrification pathway
GWC92_RS14060	COG0348	domain, Protein
GWC92_RS14065	COG0437	4 iron, 4 sulfur cluster binding
GWC92_RS14070	COG0243	molybdopterin cofactor binding
GWC92_RS14080	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWC92_RS14080	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWC92_RS14085	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GWC92_RS14090	COG3850	Histidine kinase
GWC92_RS14095	COG2197	response regulator
GWC92_RS14120	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GWC92_RS14130	COG0121	glutamine amidotransferase
GWC92_RS14135	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GWC92_RS14140	COG1960	acyl-CoA dehydrogenase activity
GWC92_RS14145	COG0784	Response regulator, receiver
GWC92_RS14145	COG3437	response regulator, receiver
GWC92_RS14155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWC92_RS14160	COG0328	RNA-DNA hybrid ribonuclease activity
GWC92_RS14165	COG2226	methyltransferase
GWC92_RS14170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWC92_RS14175	COG1388	LysM domain
GWC92_RS14175	COG0741	lytic transglycosylase activity
GWC92_RS14190	COG1607	acyl-coa hydrolase
GWC92_RS14205	COG0741	lytic transglycosylase activity
GWC92_RS14215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GWC92_RS14240	COG2911	Protein conserved in bacteria
GWC92_RS14245	COG0729	surface antigen
GWC92_RS14255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWC92_RS14265	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWC92_RS14270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWC92_RS14275	COG4134	Bacterial extracellular solute-binding protein
GWC92_RS14285	COG4136	ATPase activity
GWC92_RS14290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GWC92_RS14295	COG2951	lytic endotransglycosylase activity
GWC92_RS14300	COG1846	Transcriptional regulator
GWC92_RS14310	COG0033	Phosphoglucomutase
GWC92_RS14315	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GWC92_RS14320	COG0596	Alpha beta hydrolase
GWC92_RS14335	COG0716	FMN binding
GWC92_RS14345	COG0735	belongs to the Fur family
GWC92_RS14350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWC92_RS14360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWC92_RS14360	COG1263	PTS System
GWC92_RS14360	COG2190	(PTS) system
GWC92_RS14365	COG0363	glucosamine-6-phosphate deaminase activity
GWC92_RS14370	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWC92_RS14375	COG1940	carbohydrate kinase activity
GWC92_RS14375	COG1846	Transcriptional regulator
GWC92_RS14380	COG2194	sulfuric ester hydrolase activity
GWC92_RS14385	COG0217	transcriptional regulatory protein
GWC92_RS14390	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GWC92_RS14395	COG1801	Protein of unknown function DUF72
GWC92_RS14400	COG4106	trans-aconitate 2-methyltransferase activity
GWC92_RS14405	COG0500	methyltransferase
GWC92_RS14425	COG0583	DNA-binding transcription factor activity
GWC92_RS14430	COG0791	NLP P60 protein
GWC92_RS14445	COG1309	transcriptional regulator
GWC92_RS14455	COG1454	alcohol dehydrogenase
GWC92_RS14480	COG0534	Mate efflux family protein
GWC92_RS14490	COG2841	Protein conserved in bacteria
GWC92_RS14510	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GWC92_RS14510	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GWC92_RS14510	COG0674	pyruvate-flavodoxin oxidoreductase activity
GWC92_RS14510	COG1013	pyruvate-flavodoxin oxidoreductase activity
GWC92_RS14520	COG0633	Ferredoxin
GWC92_RS14520	COG3217	Mosc domain protein beta barrel domain protein
GWC92_RS14520	COG0633	Ferredoxin
GWC92_RS14520	COG3217	Mosc domain protein beta barrel domain protein
GWC92_RS14525	COG0501	Belongs to the peptidase M48B family
GWC92_RS14530	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GWC92_RS14535	COG2226	methyltransferase
GWC92_RS14535	COG1073	alpha beta
GWC92_RS14540	COG0156	8-amino-7-oxononanoate synthase activity
GWC92_RS14545	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GWC92_RS14565	COG0017	Asparaginyl-tRNA synthetase
GWC92_RS14570	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GWC92_RS14580	COG1473	amidohydrolase
GWC92_RS14585	COG3069	C4-dicarboxylate transmembrane transporter activity
GWC92_RS14595	COG1393	Belongs to the ArsC family
GWC92_RS14600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWC92_RS14605	COG1876	peptidase activity
GWC92_RS14615	COG3263	regulation of cellular component size
GWC92_RS14625	COG1280	lysine exporter protein (LysE YggA)
GWC92_RS14655	COG1957	nucleoside hydrolase
GWC92_RS14660	COG0564	pseudouridine synthase activity
GWC92_RS14670	COG1454	alcohol dehydrogenase
GWC92_RS14675	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWC92_RS14680	COG0702	epimerase
GWC92_RS14690	COG2867	negative regulation of translational initiation
GWC92_RS14695	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GWC92_RS14710	COG0800	Aldolase
GWC92_RS14725	COG3153	acetyltransferase
GWC92_RS14755	COG0259	pyridoxamine-phosphate oxidase activity
GWC92_RS14770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWC92_RS14770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWC92_RS14775	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GWC92_RS14800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWC92_RS14805	COG1138	Cytochrome C-type biogenesis protein
GWC92_RS14810	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GWC92_RS14815	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWC92_RS14820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWC92_RS14825	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWC92_RS14840	COG0835	chemotaxis
GWC92_RS14850	COG1192	Involved in chromosome partitioning
GWC92_RS14855	COG1360	Flagellar Motor Protein
GWC92_RS14860	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWC92_RS14865	COG2201	protein-glutamate methylesterase activity
GWC92_RS14870	COG2198	Histidine kinase
GWC92_RS14870	COG0643	Histidine kinase
GWC92_RS14870	COG0784	Response regulator, receiver
GWC92_RS14875	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GWC92_RS14900	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWC92_RS14910	COG1684	flagellar biosynthetic protein fliR
GWC92_RS14965	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWC92_RS14975	COG1677	Flagellar hook-basal body complex protein FliE
GWC92_RS14990	COG1393	Belongs to the ArsC family
GWC92_RS14995	COG0798	PFAM Bile acid sodium symporter
GWC92_RS15000	COG0640	Transcriptional regulator
GWC92_RS15010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWC92_RS15025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWC92_RS15030	COG0444	Belongs to the ABC transporter superfamily
GWC92_RS15035	COG4608	Belongs to the ABC transporter superfamily
GWC92_RS15045	COG2971	BadF BadG BcrA BcrD
GWC92_RS15055	COG0840	transmembrane signaling receptor activity
GWC92_RS15075	COG3724	N-succinylarginine dihydrolase activity
GWC92_RS15080	COG0616	signal peptide processing
GWC92_RS15085	COG1028	Short-chain dehydrogenase reductase Sdr
GWC92_RS15090	COG0583	DNA-binding transcription factor activity
GWC92_RS15100	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GWC92_RS15110	COG0583	DNA-binding transcription factor activity
GWC92_RS15120	COG1881	PFAM PEBP family protein
GWC92_RS15130	COG3408	Glycogen debranching enzyme
GWC92_RS15130	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GWC92_RS15135	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWC92_RS15140	COG0739	heme binding
GWC92_RS15145	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GWC92_RS15170	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GWC92_RS15180	COG3091	SprT-like family
GWC92_RS15190	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GWC92_RS15195	COG0189	ligase activity
GWC92_RS15205	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GWC92_RS15225	COG1115	amino acid carrier protein
GWC92_RS15230	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GWC92_RS15245	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GWC92_RS15255	COG1301	dicarboxylic acid transport
GWC92_RS15260	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GWC92_RS15265	COG2912	Transglutaminase-like superfamily
GWC92_RS15275	COG2890	protein-(glutamine-N5) methyltransferase activity
GWC92_RS15280	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GWC92_RS15285	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GWC92_RS15290	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GWC92_RS15295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GWC92_RS15305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWC92_RS15310	COG0193	aminoacyl-tRNA hydrolase activity
GWC92_RS15315	COG0012	GTP binding
GWC92_RS15360	COG0490	domain, Protein
GWC92_RS15360	COG0471	metal ion transport
GWC92_RS15445	COG1012	belongs to the aldehyde dehydrogenase family
GWC92_RS15455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWC92_RS15470	COG0180	Tryptophanyl-tRNA synthetase
GWC92_RS15475	COG0546	phosphoglycolate phosphatase activity
GWC92_RS15480	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GWC92_RS15485	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GWC92_RS15495	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GWC92_RS15500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GWC92_RS15530	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GWC92_RS15535	COG0583	DNA-binding transcription factor activity
GWC92_RS15550	COG0583	DNA-binding transcription factor activity
GWC92_RS15560	COG0739	heme binding
GWC92_RS15570	COG3264	Mechanosensitive ion channel
GWC92_RS15570	COG1511	domain protein
GWC92_RS15575	COG0584	glycerophosphoryl diester phosphodiesterase
GWC92_RS15585	COG1053	succinate dehydrogenase
GWC92_RS15590	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GWC92_RS15595	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GWC92_RS15600	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GWC92_RS15615	COG3214	Protein conserved in bacteria
GWC92_RS15620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWC92_RS15640	COG0300	oxidoreductase activity
GWC92_RS15660	COG4067	protein conserved in archaea
GWC92_RS15660	COG0189	ligase activity
GWC92_RS15665	COG0516	GMP reductase activity
GWC92_RS15675	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GWC92_RS15680	COG2011	ABC-type metal ion transport system permease component
GWC92_RS15685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWC92_RS15690	COG1464	Belongs to the NlpA lipoprotein family
GWC92_RS15705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWC92_RS15715	COG2199	diguanylate cyclase activity
GWC92_RS15725	COG2199	diguanylate cyclase activity
GWC92_RS15730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWC92_RS15745	COG1335	isochorismatase
GWC92_RS15750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWC92_RS15755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWC92_RS15760	COG1702	phosphate starvation-inducible protein PhoH
GWC92_RS15765	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GWC92_RS15770	COG4535	Mg2 and Co2 transporter CorC
GWC92_RS15775	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GWC92_RS15780	COG2888	peptidyl-tyrosine sulfation
GWC92_RS15785	COG0495	leucyl-tRNA aminoacylation
GWC92_RS15800	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GWC92_RS15805	COG0799	negative regulation of ribosome biogenesis
GWC92_RS15810	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GWC92_RS15815	COG0768	penicillin binding
GWC92_RS15820	COG0772	Belongs to the SEDS family
GWC92_RS15825	COG2951	lytic endotransglycosylase activity
GWC92_RS15830	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GWC92_RS15835	COG1686	Belongs to the peptidase S11 family
GWC92_RS15840	COG2921	Belongs to the UPF0250 family
GWC92_RS15845	COG0321	lipoyl(octanoyl) transferase activity
GWC92_RS15850	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GWC92_RS15860	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWC92_RS15875	COG0789	Transcriptional regulator
GWC92_RS15880	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GWC92_RS15890	COG1970	mechanosensitive ion channel activity
GWC92_RS15895	COG4974	Belongs to the 'phage' integrase family
GWC92_RS15905	COG0312	modulator of DNA gyrase
GWC92_RS15910	COG0312	modulator of DNA gyrase
GWC92_RS15930	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWC92_RS15935	COG1422	Protein of unknown function (DUF1090)
GWC92_RS15940	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GWC92_RS15945	COG2211	Major facilitator Superfamily
GWC92_RS15950	COG1185	polyribonucleotide nucleotidyltransferase activity
GWC92_RS15955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GWC92_RS15960	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GWC92_RS15965	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GWC92_RS15970	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GWC92_RS15975	COG0195	Participates in both transcription termination and antitermination
GWC92_RS15980	COG0779	Required for maturation of 30S ribosomal subunits
GWC92_RS15995	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWC92_RS16000	COG0149	triose-phosphate isomerase activity
GWC92_RS16005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWC92_RS16010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GWC92_RS16020	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GWC92_RS16025	COG1534	Rna-binding protein
GWC92_RS16040	COG1360	Flagellar Motor Protein
GWC92_RS16045	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWC92_RS16050	COG1722	exodeoxyribonuclease VII activity
GWC92_RS16055	COG0142	geranyltranstransferase activity
GWC92_RS16060	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GWC92_RS16080	COG4172	Belongs to the ABC transporter superfamily
GWC92_RS16085	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GWC92_RS16090	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GWC92_RS16095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWC92_RS16100	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GWC92_RS16115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWC92_RS16115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWC92_RS16120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GWC92_RS16150	COG3550	peptidyl-serine autophosphorylation
GWC92_RS16180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GWC92_RS16190	COG3381	protein complex oligomerization
GWC92_RS16210	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GWC92_RS16215	COG0511	ligase activity, forming carbon-carbon bonds
GWC92_RS16220	COG0439	Biotin carboxylase
GWC92_RS16225	COG3924	membrane
GWC92_RS16230	COG4145	pantothenate transmembrane transporter activity
GWC92_RS16235	COG1263	PTS System
GWC92_RS16235	COG2190	(PTS) system
GWC92_RS16235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWC92_RS16240	COG0583	DNA-binding transcription factor activity
GWC92_RS16245	COG0604	alcohol dehydrogenase
GWC92_RS16250	COG2264	protein methyltransferase activity
GWC92_RS16255	COG0110	maltose O-acetyltransferase activity
GWC92_RS16265	COG0778	Nitroreductase
GWC92_RS16270	COG1902	pentaerythritol trinitrate reductase activity
GWC92_RS16270	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWC92_RS16275	COG0616	signal peptide processing
GWC92_RS16295	COG3139	Protein of unknown function (DUF1315)
GWC92_RS16300	COG0252	asparaginase activity
GWC92_RS16305	COG0786	glutamate:sodium symporter activity
GWC92_RS16320	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GWC92_RS16325	COG0384	phenazine biosynthesis protein PhzF
GWC92_RS16330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GWC92_RS16335	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWC92_RS16340	COG0175	sulfate reduction
GWC92_RS16345	COG2113	Glycine betaine
GWC92_RS16350	COG4176	ABC-type proline glycine betaine transport system permease component
GWC92_RS16355	COG4175	Glycine betaine
GWC92_RS16365	COG3610	response to peptide
GWC92_RS16370	COG2966	Psort location CytoplasmicMembrane, score
GWC92_RS16380	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWC92_RS16405	COG2313	pseudouridylate synthase activity
GWC92_RS16410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWC92_RS16415	COG2146	nitrite reductase [NAD(P)H] activity
GWC92_RS16415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWC92_RS16420	COG2146	nitrite reductase [NAD(P)H] activity
GWC92_RS16420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWC92_RS16425	COG1116	anion transmembrane transporter activity
GWC92_RS16430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWC92_RS16435	COG1116	anion transmembrane transporter activity
GWC92_RS16435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GWC92_RS16445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWC92_RS16445	COG1648	precorrin-2 dehydrogenase activity
GWC92_RS16450	COG0243	molybdopterin cofactor binding
GWC92_RS16475	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GWC92_RS16495	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GWC92_RS16500	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWC92_RS16505	COG4608	Belongs to the ABC transporter superfamily
GWC92_RS16510	COG0444	Belongs to the ABC transporter superfamily
GWC92_RS16520	COG4239	(ABC) transporter, permease
GWC92_RS16525	COG4174	ABC transporter (Permease)
GWC92_RS16530	COG4206	TonB-dependent receptor
GWC92_RS16540	COG0811	peptide transport
GWC92_RS16545	COG0811	peptide transport
GWC92_RS16550	COG0848	biopolymer transport protein
GWC92_RS16600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWC92_RS16605	COG0840	transmembrane signaling receptor activity
GWC92_RS16615	COG1278	Cold shock
GWC92_RS16655	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GWC92_RS16660	COG1162	GTPase activity
GWC92_RS16665	COG0688	phosphatidylethanolamine metabolic process
GWC92_RS16670	COG4628	conserved protein (DUF2132)
GWC92_RS16690	COG5001	Diguanylate cyclase
GWC92_RS16690	COG3300	MHYT domain
GWC92_RS16695	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
GWC92_RS16720	COG1132	(ABC) transporter
GWC92_RS16730	COG2897	thiosulfate sulfurtransferase activity
GWC92_RS16735	COG2066	Belongs to the glutaminase family
GWC92_RS16740	COG3171	Protein conserved in bacteria
GWC92_RS16745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GWC92_RS16750	COG4935	Belongs to the peptidase S8 family
GWC92_RS16750	COG2234	aminopeptidase activity
GWC92_RS16755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWC92_RS16760	COG2200	EAL domain
GWC92_RS16765	COG1090	epimerase
GWC92_RS16770	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GWC92_RS16775	COG4181	ATPase activity
GWC92_RS16780	COG2755	lipolytic protein G-D-S-L family
GWC92_RS16785	COG0784	Response regulator, receiver
GWC92_RS16785	COG0835	chemotaxis
GWC92_RS16795	COG0516	GMP reductase activity
GWC92_RS16795	COG0517	IMP dehydrogenase activity
GWC92_RS16800	COG0488	(ABC) transporter
GWC92_RS16810	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GWC92_RS16855	COG0789	Transcriptional regulator
GWC92_RS16865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWC92_RS16875	COG0668	transmembrane transport
GWC92_RS16885	COG2731	YhcH YjgK YiaL family protein
GWC92_RS16895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWC92_RS16900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWC92_RS16905	COG3227	Zinc metalloprotease (Elastase)
GWC92_RS16910	COG0583	DNA-binding transcription factor activity
GWC92_RS16915	COG0477	Major facilitator Superfamily
GWC92_RS16945	COG2985	domain, Protein
GWC92_RS16945	COG0569	domain protein
GWC92_RS16950	COG1272	protein, Hemolysin III
GWC92_RS16955	COG0076	glutamate decarboxylase activity
GWC92_RS16960	COG2917	probably involved in intracellular septation
GWC92_RS16965	COG2350	Protein conserved in bacteria
GWC92_RS16975	COG1555	photosystem II stabilization
GWC92_RS16980	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWC92_RS16985	COG3104	oligopeptide transport
GWC92_RS16990	COG0745	RESPONSE REGULATOR receiver
GWC92_RS17020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWC92_RS17035	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GWC92_RS17040	COG1280	lysine exporter protein (LysE YggA)
GWC92_RS17065	COG0316	Belongs to the HesB IscA family
GWC92_RS17075	COG0038	chloride channel
GWC92_RS17080	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWC92_RS17095	COG0671	phosphoesterase, PA-phosphatase related
GWC92_RS17105	COG0583	DNA-binding transcription factor activity
GWC92_RS17110	COG2076	Multidrug Resistance protein
GWC92_RS17120	COG0346	lactoylglutathione lyase activity
GWC92_RS17125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWC92_RS17130	COG1643	Atp-dependent helicase
GWC92_RS17140	COG1489	DNA binding
GWC92_RS17145	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GWC92_RS17150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWC92_RS17160	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GWC92_RS17165	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GWC92_RS17170	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GWC92_RS17180	COG0842	Transport permease protein
GWC92_RS17185	COG1131	(ABC) transporter
GWC92_RS17200	COG0163	prenyltransferase activity
GWC92_RS17205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWC92_RS17210	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GWC92_RS17225	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GWC92_RS17240	COG1136	(ABC) transporter
GWC92_RS17310	COG0529	Catalyzes the synthesis of activated sulfate
GWC92_RS17315	COG0471	metal ion transport
GWC92_RS17315	COG3273	potassium ion transport
GWC92_RS17320	COG2895	sulfate adenylyltransferase (ATP) activity
GWC92_RS17325	COG0175	sulfate reduction
GWC92_RS17330	COG1648	precorrin-2 dehydrogenase activity
GWC92_RS17330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWC92_RS17335	COG0330	HflC and HflK could
GWC92_RS17340	COG1585	Membrane protein implicated in regulation of membrane protease activity
GWC92_RS17350	COG0673	inositol 2-dehydrogenase activity
GWC92_RS17360	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GWC92_RS17365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWC92_RS17370	COG3036	rescue of stalled ribosome
GWC92_RS17385	COG0138	bifunctional purine biosynthesis protein purh
GWC92_RS17420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GWC92_RS17425	COG0358	DNA primase activity
GWC92_RS17430	COG1610	YqeY-like protein
GWC92_RS17435	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GWC92_RS17440	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GWC92_RS17450	COG1388	LysM domain
GWC92_RS17450	COG4942	peptidase
GWC92_RS17455	COG1238	metal cluster binding
GWC92_RS17460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GWC92_RS17465	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GWC92_RS17470	COG0585	pseudouridine synthase activity
GWC92_RS17480	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GWC92_RS17485	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GWC92_RS17490	COG0148	phosphopyruvate hydratase activity
GWC92_RS17495	COG0504	CTP synthase activity
GWC92_RS17500	COG3956	TIGRFAM MazG family protein
GWC92_RS17505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWC92_RS17510	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWC92_RS17520	COG4807	Protein conserved in bacteria
GWC92_RS17525	COG3023	N-Acetylmuramoyl-L-alanine amidase
GWC92_RS17530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GWC92_RS17535	COG1381	Involved in DNA repair and RecF pathway recombination
GWC92_RS17545	COG0571	ribonuclease III activity
GWC92_RS17550	COG0681	Belongs to the peptidase S26 family
GWC92_RS17555	COG0481	GTPase activity
GWC92_RS17570	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GWC92_RS17575	COG1595	DNA-templated transcription, initiation
GWC92_RS17580	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GWC92_RS17590	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GWC92_RS17600	COG0583	DNA-binding transcription factor activity
GWC92_RS17635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWC92_RS17645	COG0126	phosphoglycerate kinase activity
GWC92_RS17650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWC92_RS17655	COG1940	carbohydrate kinase activity
GWC92_RS17660	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GWC92_RS17665	COG2816	NAD+ diphosphatase activity
GWC92_RS17670	COG4991	sh3 domain protein
GWC92_RS17675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWC92_RS17690	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GWC92_RS17695	COG1028	Short-chain dehydrogenase reductase Sdr
GWC92_RS17705	COG1505	serine-type exopeptidase activity
GWC92_RS17710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWC92_RS17715	COG0765	amino acid transport
GWC92_RS17720	COG0765	amino acid transport
GWC92_RS17725	COG1126	abc transporter atp-binding protein
GWC92_RS17730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWC92_RS17735	COG3174	membrane
GWC92_RS17740	COG0110	maltose O-acetyltransferase activity
GWC92_RS17780	COG0583	DNA-binding transcription factor activity
GWC92_RS17785	COG0165	Argininosuccinate lyase
GWC92_RS17790	COG0137	argininosuccinate synthase activity
GWC92_RS17800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWC92_RS17805	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GWC92_RS17815	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GWC92_RS17820	COG5001	Diguanylate cyclase
GWC92_RS17820	COG3447	MASE1 domain protein
GWC92_RS17820	COG5002	protein histidine kinase activity
GWC92_RS17825	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GWC92_RS17860	COG0583	DNA-binding transcription factor activity
GWC92_RS17865	COG1380	Effector of murein hydrolase LrgA
GWC92_RS17870	COG1346	cytolysis
GWC92_RS17875	COG0527	aspartate kinase activity
GWC92_RS17875	COG0460	homoserine dehydrogenase
GWC92_RS17880	COG0626	cystathionine gamma-synthase activity
GWC92_RS17895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWC92_RS17900	COG0814	amino acid
GWC92_RS17905	COG1218	3'(2'),5'-bisphosphate nucleotidase
GWC92_RS17910	COG0494	nUDIX hydrolase
GWC92_RS17915	COG1011	Hydrolase
GWC92_RS17930	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWC92_RS17945	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GWC92_RS17955	COG3156	type II secretion system protein K
GWC92_RS17960	COG4795	General secretion pathway protein
GWC92_RS17965	COG2165	general secretion pathway protein
GWC92_RS17975	COG2165	general secretion pathway protein
GWC92_RS17980	COG1459	type II secretion system
GWC92_RS17985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWC92_RS17995	COG3031	protein transport across the cell outer membrane
GWC92_RS18005	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GWC92_RS18010	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GWC92_RS18025	COG0456	acetyltransferase
GWC92_RS18030	COG3133	Outer membrane lipoprotein
GWC92_RS18035	COG3025	triphosphatase activity
GWC92_RS18040	COG1392	Phosphate transport regulator
GWC92_RS18045	COG0306	phosphate transporter
GWC92_RS18050	COG0617	tRNA 3'-terminal CCA addition
GWC92_RS18055	COG3267	Type II secretory pathway component ExeA
GWC92_RS18055	COG3409	Peptidoglycan-binding domain 1 protein
GWC92_RS18065	COG1194	a g-specific adenine glycosylase
GWC92_RS18070	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GWC92_RS18085	COG3240	lipase activity
GWC92_RS18095	COG3009	Protein conserved in bacteria
GWC92_RS18100	COG3008	intermembrane lipid transfer
GWC92_RS18100	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GWC92_RS18105	COG2995	paraquat-inducible protein a
GWC92_RS18115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWC92_RS18120	COG5001	Diguanylate cyclase
GWC92_RS18120	COG4251	negative regulation of phosphorylation
GWC92_RS18120	COG3706	GGDEF domain
GWC92_RS18120	COG2203	Gaf domain
GWC92_RS18125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWC92_RS18130	COG2813	Specifically methylates the guanine in position
GWC92_RS18135	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GWC92_RS18140	COG0297	glycogen (starch) synthase activity
GWC92_RS18180	COG1757	Na H antiporter
GWC92_RS18185	COG0583	DNA-binding transcription factor activity
GWC92_RS18190	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GWC92_RS18195	COG3842	ATPase activity
GWC92_RS18200	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWC92_RS18205	COG1177	transmembrane transport
GWC92_RS18210	COG1012	belongs to the aldehyde dehydrogenase family
GWC92_RS18215	COG0109	protoheme IX farnesyltransferase activity
GWC92_RS18245	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GWC92_RS18255	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWC92_RS18255	COG1565	acr, cog1565
GWC92_RS18260	COG1444	tRNA N-acetyltransferase activity
GWC92_RS18280	COG1803	Methylglyoxal synthase
GWC92_RS18295	COG0252	asparaginase activity
GWC92_RS18315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWC92_RS18315	COG1263	PTS System
GWC92_RS18320	COG0366	Alpha amylase catalytic
GWC92_RS18325	COG0110	maltose O-acetyltransferase activity
GWC92_RS18330	COG1522	sequence-specific DNA binding
GWC92_RS18360	COG3068	Protein conserved in bacteria
GWC92_RS18370	COG0739	heme binding
GWC92_RS18390	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GWC92_RS18395	COG1121	(ABC) transporter
GWC92_RS18400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWC92_RS18405	COG0583	DNA-binding transcription factor activity
GWC92_RS18415	COG1573	uracil-dna glycosylase
GWC92_RS18420	COG2962	Rard protein
GWC92_RS18425	COG2827	Endonuclease containing a URI domain
GWC92_RS18440	COG1842	Phage shock protein A
GWC92_RS18445	COG0204	Acyl-transferase
GWC92_RS18465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWC92_RS18475	COG0484	heat shock protein binding
GWC92_RS18510	COG2801	Transposase and inactivated derivatives
GWC92_RS18525	COG1289	transmembrane transporter activity
GWC92_RS18530	COG1566	PFAM secretion protein HlyD family protein
GWC92_RS18545	COG1051	belongs to the nudix hydrolase family
GWC92_RS18550	COG3150	esterase
GWC92_RS18560	COG3151	Protein conserved in bacteria
GWC92_RS18565	COG0494	nUDIX hydrolase
GWC92_RS18570	COG1538	Outer membrane efflux protein
GWC92_RS18575	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GWC92_RS18575	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GWC92_RS18580	COG1560	Kdo2-lipid A biosynthetic process
GWC92_RS18595	COG2771	luxR family
GWC92_RS18600	COG3916	Acyl-homoserine-lactone synthase
GWC92_RS18610	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GWC92_RS18615	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWC92_RS18615	COG2213	PTS system mannitol-specific
GWC92_RS18620	COG0246	Mannitol dehydrogenase
GWC92_RS18625	COG3722	fumarate hydratase activity
GWC92_RS18630	COG3263	regulation of cellular component size
GWC92_RS18650	COG1671	Belongs to the UPF0178 family
GWC92_RS18665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWC92_RS18670	COG0513	Belongs to the DEAD box helicase family
GWC92_RS18690	COG1575	Belongs to the MenA family. Type 1 subfamily
GWC92_RS18695	COG1169	isochorismate synthase
GWC92_RS18700	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GWC92_RS18705	COG0596	Alpha beta hydrolase
GWC92_RS18710	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GWC92_RS18720	COG0318	PFAM AMP-dependent synthetase and ligase
GWC92_RS18725	COG3291	Pkd domain containing protein
GWC92_RS18730	COG2949	membrane
GWC92_RS18735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GWC92_RS18745	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GWC92_RS18775	COG2873	o-acetylhomoserine
GWC92_RS18785	COG1979	alcohol dehydrogenase
GWC92_RS18800	COG4221	oxidoreductase activity
GWC92_RS18820	COG1285	pathogenesis
GWC92_RS18835	COG1368	sulfuric ester hydrolase activity
GWC92_RS18840	COG1522	sequence-specific DNA binding
GWC92_RS18850	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GWC92_RS18860	COG1546	Belongs to the CinA family
GWC92_RS18860	COG1058	Belongs to the CinA family
GWC92_RS18865	COG1988	membrane-bound metal-dependent
GWC92_RS18880	COG0561	phosphatase activity
GWC92_RS18885	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GWC92_RS18895	COG1011	Hydrolase
GWC92_RS18910	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GWC92_RS18915	COG0019	diaminopimelate decarboxylase activity
GWC92_RS18925	COG1965	Belongs to the frataxin family
GWC92_RS18930	COG0400	carboxylic ester hydrolase activity
GWC92_RS18935	COG3072	Adenylate cyclase
GWC92_RS18940	COG0181	hydroxymethylbilane synthase activity
GWC92_RS18945	COG1587	Uroporphyrinogen-III synthase
GWC92_RS18950	COG2959	enzyme of heme biosynthesis
GWC92_RS18955	COG3071	HemY protein
GWC92_RS18960	COG0312	modulator of DNA gyrase
GWC92_RS18965	COG3028	Belongs to the UPF0307 family
GWC92_RS18975	COG2926	Belongs to the UPF0265 family
GWC92_RS19005	COG1396	sequence-specific DNA binding
GWC92_RS19010	COG3135	benzoate transporter
GWC92_RS19035	COG0840	transmembrane signaling receptor activity
GWC92_RS19040	COG3047	cAMP biosynthetic process
GWC92_RS19045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWC92_RS19050	COG2197	response regulator
GWC92_RS19095	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWC92_RS19125	COG2801	Transposase and inactivated derivatives
GWC92_RS19135	COG1396	sequence-specific DNA binding
GWC92_RS19155	COG1278	Cold shock
GWC92_RS19160	COG2205	protein histidine kinase activity
GWC92_RS19165	COG0745	RESPONSE REGULATOR receiver
GWC92_RS19185	COG3706	GGDEF domain
GWC92_RS19190	COG0347	Belongs to the P(II) protein family
GWC92_RS19195	COG0004	ammonium transporteR
GWC92_RS19220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWC92_RS19225	COG1074	ATP-dependent DNA helicase activity
GWC92_RS19230	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GWC92_RS19235	COG2259	Doxx family
GWC92_RS19240	COG1741	Belongs to the pirin family
GWC92_RS19250	COG0583	DNA-binding transcription factor activity
GWC92_RS19275	COG1175	transmembrane transport
GWC92_RS19285	COG3842	ATPase activity
GWC92_RS19315	COG0456	acetyltransferase
GWC92_RS19320	COG0753	catalase activity
GWC92_RS19340	COG0494	nUDIX hydrolase
GWC92_RS19345	COG0628	permease
GWC92_RS19355	COG2957	Belongs to the agmatine deiminase family
GWC92_RS19370	COG2957	Belongs to the agmatine deiminase family
GWC92_RS19375	COG0583	DNA-binding transcription factor activity
GWC92_RS19390	COG1461	Dihydroxyacetone kinase
GWC92_RS19395	COG2376	Dihydroxyacetone kinase
GWC92_RS19400	COG2252	PERMEase
GWC92_RS19405	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GWC92_RS19435	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GWC92_RS19440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWC92_RS19445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWC92_RS19450	COG0049	tRNA binding
GWC92_RS19455	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GWC92_RS19460	COG2168	tRNA wobble position uridine thiolation
GWC92_RS19470	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GWC92_RS19475	COG0251	oxidation-reduction process
GWC92_RS19480	COG2964	Protein conserved in bacteria
GWC92_RS19485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GWC92_RS19490	COG0085	RNA polymerase activity
GWC92_RS19495	COG0222	ribosome binding
GWC92_RS19500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GWC92_RS19505	COG0081	regulation of translation
GWC92_RS19510	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GWC92_RS19515	COG0250	Participates in transcription elongation, termination and antitermination
GWC92_RS19530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWC92_RS19555	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GWC92_RS19560	COG0569	domain protein
GWC92_RS19565	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWC92_RS19570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GWC92_RS19575	COG3005	denitrification pathway
GWC92_RS19580	COG0243	molybdopterin cofactor binding
GWC92_RS19595	COG0745	RESPONSE REGULATOR receiver
GWC92_RS19615	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GWC92_RS19625	COG2204	response regulator
GWC92_RS19635	COG2205	protein histidine kinase activity
GWC92_RS19655	COG0516	GMP reductase activity
GWC92_RS19655	COG0517	IMP dehydrogenase activity
GWC92_RS19665	COG1522	sequence-specific DNA binding
GWC92_RS19670	COG2502	aspartate--ammonia ligase
GWC92_RS19685	COG0583	DNA-binding transcription factor activity
GWC92_RS19695	COG5001	Diguanylate cyclase
GWC92_RS19695	COG2203	Gaf domain
GWC92_RS19695	COG3706	GGDEF domain
GWC92_RS19695	COG4251	negative regulation of phosphorylation
GWC92_RS19715	COG0814	amino acid
GWC92_RS19720	COG0814	amino acid
GWC92_RS19725	COG3033	Beta-eliminating lyase
GWC92_RS19735	COG0348	domain, Protein
GWC92_RS19745	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWC92_RS19750	COG1773	rubredoxin
GWC92_RS19750	COG0426	domain, Protein
GWC92_RS19755	COG3604	Transcriptional regulator
GWC92_RS19785	COG0751	glycine-tRNA ligase activity
GWC92_RS19790	COG0752	glycyl-tRNA synthetase alpha subunit
GWC92_RS19795	COG2818	Glycosylase
GWC92_RS19800	COG1335	isochorismatase
GWC92_RS19810	COG2885	chlorophyll binding
GWC92_RS19815	COG0251	oxidation-reduction process
GWC92_RS19820	COG0425	Belongs to the sulfur carrier protein TusA family
GWC92_RS19845	COG0745	RESPONSE REGULATOR receiver
GWC92_RS19850	COG0183	Belongs to the thiolase family
GWC92_RS19855	COG1024	Enoyl-CoA hydratase
GWC92_RS19855	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWC92_RS19860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWC92_RS19865	COG0006	proline dipeptidase activity
GWC92_RS19870	COG1739	Uncharacterized protein family UPF0029
GWC92_RS19875	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWC92_RS19880	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GWC92_RS19915	COG0045	succinate-CoA ligase (ADP-forming) activity
GWC92_RS19915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWC92_RS19915	COG1042	CoA-binding domain protein
GWC92_RS19925	COG0583	DNA-binding transcription factor activity
GWC92_RS19930	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GWC92_RS19935	COG0166	Belongs to the GPI family
GWC92_RS19945	COG0668	transmembrane transport
GWC92_RS19960	COG1309	transcriptional regulator
GWC92_RS19965	COG0756	dUTP diphosphatase activity
GWC92_RS19970	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GWC92_RS19975	COG2003	Belongs to the UPF0758 family
GWC92_RS19980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GWC92_RS19985	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GWC92_RS19995	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GWC92_RS20000	COG2990	Protein conserved in bacteria
GWC92_RS20005	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GWC92_RS20010	COG0859	PFAM glycosyl transferase family 9
GWC92_RS20015	COG0463	Glycosyl transferase, family 2
GWC92_RS20020	COG0859	PFAM glycosyl transferase family 9
GWC92_RS20025	COG1519	Transferase
GWC92_RS20035	COG1561	YicC-like family, N-terminal region
GWC92_RS20040	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GWC92_RS20045	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GWC92_RS20060	COG2203	Gaf domain
GWC92_RS20060	COG5001	Diguanylate cyclase
GWC92_RS20060	COG3706	GGDEF domain
GWC92_RS20060	COG4251	negative regulation of phosphorylation
GWC92_RS20065	COG3084	Protein conserved in bacteria
GWC92_RS20075	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GWC92_RS20080	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GWC92_RS20090	COG1335	isochorismatase
GWC92_RS20100	COG1683	Conserved Protein
GWC92_RS20105	COG0204	Acyl-transferase
GWC92_RS20110	COG0204	Acyl-transferase
GWC92_RS20115	COG0606	chelatase, subunit chli
GWC92_RS20125	COG3978	acetolactate synthase activity
GWC92_RS20135	COG0129	dihydroxy-acid dehydratase activity
GWC92_RS20155	COG1309	transcriptional regulator
GWC92_RS20160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GWC92_RS20165	COG0254	rRNA binding
GWC92_RS20170	COG0702	epimerase
GWC92_RS20175	COG0281	malic enzyme
GWC92_RS20185	COG2205	protein histidine kinase activity
GWC92_RS20190	COG0745	RESPONSE REGULATOR receiver
GWC92_RS20195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWC92_RS20230	COG4310	Domain of unknown function (DUF2172)
GWC92_RS20240	COG0366	Alpha amylase catalytic
GWC92_RS20255	COG0443	Heat shock 70 kDa protein
GWC92_RS20260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWC92_RS20265	COG3045	CreA protein
GWC92_RS20285	COG0174	glutamine synthetase
GWC92_RS20305	COG3842	ATPase activity
GWC92_RS20310	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWC92_RS20315	COG1177	transmembrane transport
GWC92_RS20320	COG2258	MOSC domain
GWC92_RS20335	COG2050	protein possibly involved in aromatic compounds catabolism
GWC92_RS20340	COG0514	ATP-dependent DNA helicase (RecQ)
GWC92_RS20345	COG0514	ATP-dependent DNA helicase (RecQ)
GWC92_RS20355	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GWC92_RS20365	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GWC92_RS20370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GWC92_RS20375	COG2239	Acts as a magnesium transporter
GWC92_RS20380	COG1648	precorrin-2 dehydrogenase activity
GWC92_RS20380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWC92_RS20385	COG2116	formate transmembrane transporter activity
GWC92_RS20395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWC92_RS20400	COG0842	Transport permease protein
GWC92_RS20405	COG0842	Transport permease protein
GWC92_RS20410	COG1131	(ABC) transporter
GWC92_RS20415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWC92_RS20430	COG0477	Major facilitator Superfamily
GWC92_RS20435	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GWC92_RS20440	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GWC92_RS20460	COG1595	DNA-templated transcription, initiation
GWC92_RS20465	COG3806	Anti-sigma factor
GWC92_RS20470	COG1968	undecaprenyl-diphosphatase activity
GWC92_RS20475	COG0667	Aldo Keto reductase
GWC92_RS20480	COG2017	converts alpha-aldose to the beta-anomer
GWC92_RS20485	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWC92_RS20495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWC92_RS20500	COG1609	Transcriptional regulator
GWC92_RS20505	COG3250	beta-galactosidase activity
GWC92_RS20545	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWC92_RS20550	COG1288	antiporter activity
GWC92_RS20555	COG1438	arginine binding
GWC92_RS20560	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GWC92_RS20565	COG0540	Belongs to the ATCase OTCase family
GWC92_RS20585	COG0583	DNA-binding transcription factor activity
GWC92_RS20595	COG0840	transmembrane signaling receptor activity
GWC92_RS20605	COG3040	lipid binding
GWC92_RS20610	COG2207	Transcriptional regulator
GWC92_RS20615	COG1979	alcohol dehydrogenase
GWC92_RS20620	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GWC92_RS20625	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GWC92_RS20630	COG2964	Protein conserved in bacteria
GWC92_RS20635	COG3681	Belongs to the UPF0597 family
GWC92_RS20640	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWC92_RS20645	COG0564	pseudouridine synthase activity
GWC92_RS20655	COG0542	response to heat
GWC92_RS20665	COG1609	Transcriptional regulator
GWC92_RS20705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWC92_RS20720	COG2960	long-chain fatty acid transporting porin activity
GWC92_RS20730	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GWC92_RS20745	COG3118	belongs to the thioredoxin family
GWC92_RS20750	COG0513	Belongs to the DEAD box helicase family
GWC92_RS20755	COG0248	Ppx GppA phosphatase
GWC92_RS20765	COG0742	ribosomal rna small subunit methyltransferase
GWC92_RS20785	COG0084	hydrolase, TatD family'
GWC92_RS20790	COG0805	protein transport
GWC92_RS20795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWC92_RS20800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWC92_RS20805	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GWC92_RS20810	COG3165	ubiquinone biosynthetic process from chorismate
GWC92_RS20820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GWC92_RS20825	COG0402	S-adenosylhomocysteine deaminase activity
GWC92_RS20860	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GWC92_RS20865	COG0848	biopolymer transport protein
GWC92_RS20870	COG0811	peptide transport
GWC92_RS20875	COG0811	peptide transport
GWC92_RS20885	COG2771	luxR family
GWC92_RS20890	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GWC92_RS20895	COG1349	DNA-binding transcription factor activity
GWC92_RS20900	COG0745	RESPONSE REGULATOR receiver
GWC92_RS20905	COG2205	protein histidine kinase activity
GWC92_RS20915	COG4452	Inner membrane protein CreD
GWC92_RS20920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GWC92_RS20925	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GWC92_RS20930	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GWC92_RS20935	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GWC92_RS20940	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GWC92_RS20945	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GWC92_RS20950	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GWC92_RS20960	COG0356	it plays a direct role in the translocation of protons across the membrane
GWC92_RS20970	COG1475	DNA binding
GWC92_RS20975	COG1192	Involved in chromosome partitioning
GWC92_RS20980	COG0357	Ribosomal RNA small subunit methyltransferase G
GWC92_RS20985	COG0445	tRNA wobble uridine modification
GWC92_RS20990	COG0716	FMN binding
GWC92_RS21000	COG4615	Cyclic peptide transporter
GWC92_RS21005	COG1120	ATPase activity
GWC92_RS21010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWC92_RS21020	COG3550	peptidyl-serine autophosphorylation
GWC92_RS21070	COG1695	Transcriptional regulator
GWC92_RS21095	COG3173	Aminoglycoside phosphotransferase
GWC92_RS21185	COG4974	Belongs to the 'phage' integrase family
GWC92_RS21190	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GWC92_RS21195	COG0706	membrane insertase activity
GWC92_RS21200	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GWC92_RS21205	COG0594	ribonuclease P activity
GWC92_RS21210	COG0230	Belongs to the bacterial ribosomal protein bL34 family