locus-tag	class	description
VI35_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VI35_RS00010	COG0592	DNA-directed DNA polymerase activity
VI35_RS00020	COG0187	DNA topoisomerase II activity
VI35_RS00025	COG2207	Transcriptional regulator
VI35_RS00030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
VI35_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
VI35_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
VI35_RS00045	COG3977	Valine--pyruvate aminotransferase
VI35_RS00060	COG2814	Major facilitator Superfamily
VI35_RS00065	COG0745	RESPONSE REGULATOR receiver
VI35_RS00095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VI35_RS00110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VI35_RS00115	COG1309	transcriptional regulator
VI35_RS00145	COG0561	phosphatase activity
VI35_RS00150	COG2267	carboxylic ester hydrolase activity
VI35_RS00155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VI35_RS00160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VI35_RS00165	COG1758	RNA polymerase activity
VI35_RS00185	COG3642	lipopolysaccharide core region biosynthetic process
VI35_RS00225	COG0589	response to stress
VI35_RS00230	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VI35_RS00235	COG3706	GGDEF domain
VI35_RS00240	COG1528	Iron-storage protein
VI35_RS00245	COG2081	HI0933 family
VI35_RS00250	COG2223	nitrite transmembrane transporter activity
VI35_RS00255	COG1280	lysine exporter protein (LysE YggA)
VI35_RS00270	COG3188	usher protein
VI35_RS00290	COG2205	protein histidine kinase activity
VI35_RS00290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VI35_RS00300	COG3275	phosphorelay sensor kinase activity
VI35_RS00305	COG3279	Response regulator of the LytR AlgR family
VI35_RS00310	COG2223	nitrite transmembrane transporter activity
VI35_RS00315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VI35_RS00320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VI35_RS00360	COG0045	succinate-CoA ligase (ADP-forming) activity
VI35_RS00360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VI35_RS00360	COG1042	CoA-binding domain protein
VI35_RS00370	COG0583	DNA-binding transcription factor activity
VI35_RS00375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VI35_RS00380	COG0166	Belongs to the GPI family
VI35_RS00390	COG0668	transmembrane transport
VI35_RS00395	COG1309	transcriptional regulator
VI35_RS00400	COG0756	dUTP diphosphatase activity
VI35_RS00405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VI35_RS00410	COG2003	Belongs to the UPF0758 family
VI35_RS00415	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VI35_RS00420	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VI35_RS00430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VI35_RS00435	COG2990	Protein conserved in bacteria
VI35_RS00440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VI35_RS00445	COG0859	PFAM glycosyl transferase family 9
VI35_RS00450	COG0463	Glycosyl transferase, family 2
VI35_RS00455	COG0859	PFAM glycosyl transferase family 9
VI35_RS00460	COG1519	Transferase
VI35_RS00470	COG3171	Protein conserved in bacteria
VI35_RS00475	COG0732	type I restriction modification DNA specificity domain
VI35_RS00480	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VI35_RS00485	COG3177	Filamentation induced by cAMP protein fic
VI35_RS00495	COG1715	Restriction endonuclease
VI35_RS00500	COG1561	YicC-like family, N-terminal region
VI35_RS00505	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VI35_RS00510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VI35_RS00525	COG4251	negative regulation of phosphorylation
VI35_RS00525	COG2203	Gaf domain
VI35_RS00525	COG5001	Diguanylate cyclase
VI35_RS00525	COG3706	GGDEF domain
VI35_RS00530	COG3084	Protein conserved in bacteria
VI35_RS00540	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VI35_RS00545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VI35_RS00555	COG1335	isochorismatase
VI35_RS00565	COG1683	Conserved Protein
VI35_RS00570	COG0204	Acyl-transferase
VI35_RS00575	COG0204	Acyl-transferase
VI35_RS00595	COG3978	acetolactate synthase activity
VI35_RS00605	COG0129	dihydroxy-acid dehydratase activity
VI35_RS00625	COG1309	transcriptional regulator
VI35_RS00635	COG0254	rRNA binding
VI35_RS00645	COG0281	malic enzyme
VI35_RS00670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VI35_RS00705	COG4310	Domain of unknown function (DUF2172)
VI35_RS00715	COG0366	Alpha amylase catalytic
VI35_RS00735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VI35_RS00740	COG3045	CreA protein
VI35_RS00760	COG0174	glutamine synthetase
VI35_RS00780	COG3842	ATPase activity
VI35_RS00785	COG1176	ABC-type spermidine putrescine transport system, permease component I
VI35_RS00790	COG1177	transmembrane transport
VI35_RS00795	COG2258	MOSC domain
VI35_RS00810	COG2050	protein possibly involved in aromatic compounds catabolism
VI35_RS00815	COG0514	ATP-dependent DNA helicase (RecQ)
VI35_RS00825	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VI35_RS00835	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VI35_RS00840	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VI35_RS00850	COG1648	precorrin-2 dehydrogenase activity
VI35_RS00850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VI35_RS00855	COG2116	formate transmembrane transporter activity
VI35_RS00865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VI35_RS00870	COG0842	Transport permease protein
VI35_RS00885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VI35_RS00905	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VI35_RS00910	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VI35_RS00930	COG1595	DNA-templated transcription, initiation
VI35_RS00935	COG3806	Anti-sigma factor
VI35_RS00940	COG1968	undecaprenyl-diphosphatase activity
VI35_RS00950	COG2017	converts alpha-aldose to the beta-anomer
VI35_RS00965	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VI35_RS00970	COG1609	Transcriptional regulator
VI35_RS00975	COG3250	beta-galactosidase activity
VI35_RS01015	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VI35_RS01025	COG1438	arginine binding
VI35_RS01035	COG0540	Belongs to the ATCase OTCase family
VI35_RS01070	COG3040	lipid binding
VI35_RS01080	COG1979	alcohol dehydrogenase
VI35_RS01085	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VI35_RS01090	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VI35_RS01095	COG2964	Protein conserved in bacteria
VI35_RS01100	COG3681	Belongs to the UPF0597 family
VI35_RS01105	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VI35_RS01110	COG0564	pseudouridine synthase activity
VI35_RS01125	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
VI35_RS01130	COG2502	aspartate--ammonia ligase
VI35_RS01135	COG1522	sequence-specific DNA binding
VI35_RS01145	COG0516	GMP reductase activity
VI35_RS01145	COG0517	IMP dehydrogenase activity
VI35_RS01165	COG2205	protein histidine kinase activity
VI35_RS01175	COG2204	response regulator
VI35_RS01190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
VI35_RS01230	COG3005	denitrification pathway
VI35_RS01235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VI35_RS01245	COG0569	domain protein
VI35_RS01250	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VI35_RS01275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VI35_RS01290	COG0250	Participates in transcription elongation, termination and antitermination
VI35_RS01295	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VI35_RS01300	COG0081	regulation of translation
VI35_RS01305	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VI35_RS01310	COG0222	ribosome binding
VI35_RS01315	COG0085	RNA polymerase activity
VI35_RS01320	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VI35_RS01325	COG2964	Protein conserved in bacteria
VI35_RS01330	COG0251	oxidation-reduction process
VI35_RS01335	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VI35_RS01345	COG2168	tRNA wobble position uridine thiolation
VI35_RS01350	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VI35_RS01355	COG0049	tRNA binding
VI35_RS01360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VI35_RS01365	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VI35_RS01370	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VI35_RS01410	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
VI35_RS01415	COG2252	PERMEase
VI35_RS01420	COG2376	Dihydroxyacetone kinase
VI35_RS01425	COG1461	Dihydroxyacetone kinase
VI35_RS01440	COG0583	DNA-binding transcription factor activity
VI35_RS01445	COG2957	Belongs to the agmatine deiminase family
VI35_RS01460	COG2957	Belongs to the agmatine deiminase family
VI35_RS01470	COG0628	permease
VI35_RS01475	COG0494	nUDIX hydrolase
VI35_RS01495	COG0753	catalase activity
VI35_RS01500	COG0456	acetyltransferase
VI35_RS01530	COG3842	ATPase activity
VI35_RS01540	COG1175	transmembrane transport
VI35_RS01565	COG0583	DNA-binding transcription factor activity
VI35_RS01575	COG1741	Belongs to the pirin family
VI35_RS01580	COG2259	Doxx family
VI35_RS01595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VI35_RS01610	COG0346	lactoylglutathione lyase activity
VI35_RS01620	COG0004	ammonium transporteR
VI35_RS01625	COG0347	Belongs to the P(II) protein family
VI35_RS01660	COG1278	Cold shock
VI35_RS01685	COG2197	response regulator
VI35_RS01695	COG3047	cAMP biosynthetic process
VI35_RS01725	COG3135	benzoate transporter
VI35_RS01730	COG1396	sequence-specific DNA binding
VI35_RS01760	COG2926	Belongs to the UPF0265 family
VI35_RS01770	COG3028	Belongs to the UPF0307 family
VI35_RS01775	COG0312	modulator of DNA gyrase
VI35_RS01780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VI35_RS01785	COG5007	Belongs to the BolA IbaG family
VI35_RS01795	COG2854	intermembrane phospholipid transfer
VI35_RS01800	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VI35_RS01805	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VI35_RS01810	COG1127	ABC transporter
VI35_RS01815	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VI35_RS01815	COG0517	IMP dehydrogenase activity
VI35_RS01820	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VI35_RS01830	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VI35_RS01835	COG1137	ATPase activity
VI35_RS01840	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
VI35_RS01850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VI35_RS01855	COG1660	Displays ATPase and GTPase activities
VI35_RS01860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VI35_RS01880	COG3964	amidohydrolase
VI35_RS01910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VI35_RS01915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VI35_RS01930	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VI35_RS01935	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VI35_RS01940	COG0723	plastoquinol--plastocyanin reductase activity
VI35_RS01945	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VI35_RS01955	COG0625	glutathione transferase activity
VI35_RS01960	COG2969	positive regulation of protein catabolic process
VI35_RS01965	COG2823	Periplasmic or secreted lipoprotein
VI35_RS01970	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VI35_RS01975	COG0792	nuclease activity
VI35_RS01980	COG3107	peptidoglycan biosynthetic process
VI35_RS01985	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VI35_RS02010	COG1987	bacterial-type flagellum assembly
VI35_RS02045	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VI35_RS02075	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
VI35_RS02080	COG1815	bacterial-type flagellum-dependent cell motility
VI35_RS02095	COG1749	Flagellar hook protein flgE
VI35_RS02105	COG4786	Flagellar basal body rod
VI35_RS02110	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VI35_RS02115	COG1706	bacterial-type flagellum-dependent cell motility
VI35_RS02125	COG4786	Flagellar basal body rod
VI35_RS02125	COG1256	bacterial-type flagellum assembly
VI35_RS02150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VI35_RS02155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VI35_RS02160	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VI35_RS02185	COG1191	sigma factor activity
VI35_RS02190	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VI35_RS02195	COG1360	Flagellar Motor Protein
VI35_RS02205	COG1388	LysM domain
VI35_RS02205	COG0741	lytic transglycosylase activity
VI35_RS02215	COG2001	Belongs to the MraZ family
VI35_RS02225	COG3116	cell division
VI35_RS02230	COG0768	penicillin binding
VI35_RS02235	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VI35_RS02240	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VI35_RS02245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VI35_RS02255	COG0772	Belongs to the SEDS family
VI35_RS02260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VI35_RS02265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VI35_RS02275	COG0849	cell division
VI35_RS02280	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VI35_RS02285	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VI35_RS02295	COG0653	protein targeting
VI35_RS02305	COG0494	nUDIX hydrolase
VI35_RS02310	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VI35_RS02315	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VI35_RS02325	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
VI35_RS02330	COG1459	type II secretion system
VI35_RS02335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VI35_RS02365	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VI35_RS02370	COG0508	dehydrogenase complex catalyzes the overall conversion of
VI35_RS02375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VI35_RS02385	COG0840	transmembrane signaling receptor activity
VI35_RS02390	COG0840	transmembrane signaling receptor activity
VI35_RS02395	COG1752	Esterase of the alpha-beta hydrolase superfamily
VI35_RS02400	COG1049	propionate catabolic process, 2-methylcitrate cycle
VI35_RS02405	COG2200	EAL domain
VI35_RS02415	COG1280	lysine exporter protein (LysE YggA)
VI35_RS02425	COG0523	cobalamin synthesis protein
VI35_RS02430	COG0477	Major facilitator Superfamily
VI35_RS02445	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VI35_RS02450	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VI35_RS02500	COG1522	sequence-specific DNA binding
VI35_RS02505	COG0110	maltose O-acetyltransferase activity
VI35_RS02515	COG1263	PTS System
VI35_RS02515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VI35_RS02535	COG0252	asparaginase activity
VI35_RS02550	COG1803	Methylglyoxal synthase
VI35_RS02570	COG1444	tRNA N-acetyltransferase activity
VI35_RS02575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VI35_RS02575	COG1565	acr, cog1565
VI35_RS02585	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
VI35_RS02615	COG0109	protoheme IX farnesyltransferase activity
VI35_RS02625	COG1177	transmembrane transport
VI35_RS02630	COG1176	ABC-type spermidine putrescine transport system, permease component I
VI35_RS02635	COG3842	ATPase activity
VI35_RS02645	COG0583	DNA-binding transcription factor activity
VI35_RS02690	COG0297	glycogen (starch) synthase activity
VI35_RS02695	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VI35_RS02705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VI35_RS02715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VI35_RS02725	COG2995	paraquat-inducible protein a
VI35_RS02730	COG3008	intermembrane lipid transfer
VI35_RS02730	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VI35_RS02735	COG3009	Protein conserved in bacteria
VI35_RS02745	COG3240	lipase activity
VI35_RS02760	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VI35_RS02765	COG1194	a g-specific adenine glycosylase
VI35_RS02775	COG3267	Type II secretory pathway component ExeA
VI35_RS02775	COG3409	Peptidoglycan-binding domain 1 protein
VI35_RS02780	COG0617	tRNA 3'-terminal CCA addition
VI35_RS02785	COG0306	phosphate transporter
VI35_RS02790	COG1392	Phosphate transport regulator
VI35_RS02800	COG3133	Outer membrane lipoprotein
VI35_RS02805	COG0456	acetyltransferase
VI35_RS02820	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VI35_RS02825	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VI35_RS02835	COG3031	protein transport across the cell outer membrane
VI35_RS02845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VI35_RS02850	COG1459	type II secretion system
VI35_RS02855	COG2165	general secretion pathway protein
VI35_RS02865	COG2165	general secretion pathway protein
VI35_RS02870	COG4795	General secretion pathway protein
VI35_RS02890	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VI35_RS02905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VI35_RS02915	COG1902	pentaerythritol trinitrate reductase activity
VI35_RS02920	COG1011	Hydrolase
VI35_RS02925	COG0494	nUDIX hydrolase
VI35_RS02930	COG1218	3'(2'),5'-bisphosphate nucleotidase
VI35_RS02940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VI35_RS02955	COG0626	cystathionine gamma-synthase activity
VI35_RS02960	COG0460	homoserine dehydrogenase
VI35_RS02960	COG0527	aspartate kinase activity
VI35_RS02965	COG1346	cytolysis
VI35_RS02970	COG1380	Effector of murein hydrolase LrgA
VI35_RS02975	COG0583	DNA-binding transcription factor activity
VI35_RS03020	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VI35_RS03030	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VI35_RS03035	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VI35_RS03045	COG0137	argininosuccinate synthase activity
VI35_RS03050	COG0165	Argininosuccinate lyase
VI35_RS03055	COG0583	DNA-binding transcription factor activity
VI35_RS03065	COG1942	4-Oxalocrotonate Tautomerase
VI35_RS03095	COG4932	domain protein
VI35_RS03095	COG5492	domain, Protein
VI35_RS03110	COG0110	maltose O-acetyltransferase activity
VI35_RS03115	COG3174	membrane
VI35_RS03120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VI35_RS03125	COG1126	abc transporter atp-binding protein
VI35_RS03130	COG0765	amino acid transport
VI35_RS03135	COG0765	amino acid transport
VI35_RS03140	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VI35_RS03160	COG1028	Short-chain dehydrogenase reductase Sdr
VI35_RS03180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VI35_RS03185	COG4991	sh3 domain protein
VI35_RS03190	COG2816	NAD+ diphosphatase activity
VI35_RS03195	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VI35_RS03200	COG1940	carbohydrate kinase activity
VI35_RS03210	COG0126	phosphoglycerate kinase activity
VI35_RS03220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VI35_RS03250	COG0583	DNA-binding transcription factor activity
VI35_RS03255	COG0354	folic acid binding
VI35_RS03260	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VI35_RS03270	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VI35_RS03275	COG1595	DNA-templated transcription, initiation
VI35_RS03280	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
VI35_RS03295	COG0481	GTPase activity
VI35_RS03300	COG0681	Belongs to the peptidase S26 family
VI35_RS03305	COG0571	ribonuclease III activity
VI35_RS03315	COG1381	Involved in DNA repair and RecF pathway recombination
VI35_RS03320	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VI35_RS03330	COG4807	Protein conserved in bacteria
VI35_RS03340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VI35_RS03345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VI35_RS03350	COG3956	TIGRFAM MazG family protein
VI35_RS03355	COG0504	CTP synthase activity
VI35_RS03360	COG0148	phosphopyruvate hydratase activity
VI35_RS03365	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VI35_RS03370	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VI35_RS03380	COG0585	pseudouridine synthase activity
VI35_RS03390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VI35_RS03395	COG1238	metal cluster binding
VI35_RS03400	COG4942	peptidase
VI35_RS03400	COG1388	LysM domain
VI35_RS03410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VI35_RS03415	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VI35_RS03420	COG1610	YqeY-like protein
VI35_RS03425	COG0358	DNA primase activity
VI35_RS03430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VI35_RS03465	COG0138	bifunctional purine biosynthesis protein purh
VI35_RS03480	COG3036	rescue of stalled ribosome
VI35_RS03490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VI35_RS03505	COG0673	inositol 2-dehydrogenase activity
VI35_RS03515	COG1585	Membrane protein implicated in regulation of membrane protease activity
VI35_RS03520	COG0330	HflC and HflK could
VI35_RS03525	COG1648	precorrin-2 dehydrogenase activity
VI35_RS03525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VI35_RS03530	COG0175	sulfate reduction
VI35_RS03535	COG2895	sulfate adenylyltransferase (ATP) activity
VI35_RS03540	COG3273	potassium ion transport
VI35_RS03540	COG0471	metal ion transport
VI35_RS03545	COG0529	Catalyzes the synthesis of activated sulfate
VI35_RS03580	COG1136	(ABC) transporter
VI35_RS03595	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VI35_RS03610	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VI35_RS03615	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VI35_RS03620	COG0163	prenyltransferase activity
VI35_RS03635	COG1131	(ABC) transporter
VI35_RS03640	COG0842	Transport permease protein
VI35_RS03655	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VI35_RS03675	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VI35_RS03680	COG1489	DNA binding
VI35_RS03690	COG1643	Atp-dependent helicase
VI35_RS03700	COG0346	lactoylglutathione lyase activity
VI35_RS03710	COG2076	Multidrug Resistance protein
VI35_RS03740	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VI35_RS03780	COG1280	lysine exporter protein (LysE YggA)
VI35_RS03785	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VI35_RS03800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VI35_RS03830	COG0745	RESPONSE REGULATOR receiver
VI35_RS03835	COG3104	oligopeptide transport
VI35_RS03840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
VI35_RS03845	COG1555	photosystem II stabilization
VI35_RS03855	COG2350	Protein conserved in bacteria
VI35_RS03860	COG2917	probably involved in intracellular septation
VI35_RS03865	COG0076	glutamate decarboxylase activity
VI35_RS03870	COG1272	protein, Hemolysin III
VI35_RS03875	COG0569	domain protein
VI35_RS03875	COG2985	domain, Protein
VI35_RS03965	COG0477	Major facilitator Superfamily
VI35_RS03970	COG0583	DNA-binding transcription factor activity
VI35_RS03975	COG3227	Zinc metalloprotease (Elastase)
VI35_RS03980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VI35_RS03985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VI35_RS03995	COG2731	YhcH YjgK YiaL family protein
VI35_RS04005	COG0668	transmembrane transport
VI35_RS04015	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VI35_RS04025	COG0789	Transcriptional regulator
VI35_RS04065	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VI35_RS04075	COG0488	(ABC) transporter
VI35_RS04080	COG0517	IMP dehydrogenase activity
VI35_RS04080	COG0516	GMP reductase activity
VI35_RS04090	COG0784	Response regulator, receiver
VI35_RS04090	COG0835	chemotaxis
VI35_RS04100	COG4181	ATPase activity
VI35_RS04120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VI35_RS04125	COG4935	Belongs to the peptidase S8 family
VI35_RS04125	COG2234	aminopeptidase activity
VI35_RS04130	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VI35_RS04135	COG3171	Protein conserved in bacteria
VI35_RS04140	COG2066	Belongs to the glutaminase family
VI35_RS04150	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VI35_RS04190	COG1132	(ABC) transporter
VI35_RS04220	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
VI35_RS04225	COG3300	MHYT domain
VI35_RS04225	COG5001	Diguanylate cyclase
VI35_RS04245	COG4628	conserved protein (DUF2132)
VI35_RS04255	COG1162	GTPase activity
VI35_RS04260	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VI35_RS04300	COG1278	Cold shock
VI35_RS04310	COG0840	transmembrane signaling receptor activity
VI35_RS04315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VI35_RS04320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VI35_RS04325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VI35_RS04375	COG0848	biopolymer transport protein
VI35_RS04380	COG0811	peptide transport
VI35_RS04385	COG0811	peptide transport
VI35_RS04400	COG4174	ABC transporter (Permease)
VI35_RS04405	COG4239	(ABC) transporter, permease
VI35_RS04415	COG0444	Belongs to the ABC transporter superfamily
VI35_RS04420	COG4608	Belongs to the ABC transporter superfamily
VI35_RS04430	COG2195	Cleaves the N-terminal amino acid of tripeptides
VI35_RS04440	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VI35_RS04445	COG1073	alpha beta
VI35_RS04460	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VI35_RS04485	COG0243	molybdopterin cofactor binding
VI35_RS04490	COG1648	precorrin-2 dehydrogenase activity
VI35_RS04490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VI35_RS04505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VI35_RS04520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VI35_RS04520	COG2146	nitrite reductase [NAD(P)H] activity
VI35_RS04525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VI35_RS04530	COG2313	pseudouridylate synthase activity
VI35_RS04550	COG0521	Mo-molybdopterin cofactor biosynthetic process
VI35_RS04560	COG2966	Psort location CytoplasmicMembrane, score
VI35_RS04565	COG3610	response to peptide
VI35_RS04575	COG4175	Glycine betaine
VI35_RS04580	COG4176	ABC-type proline glycine betaine transport system permease component
VI35_RS04585	COG2113	Glycine betaine
VI35_RS04590	COG0175	sulfate reduction
VI35_RS04600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VI35_RS04610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VI35_RS04625	COG0786	glutamate:sodium symporter activity
VI35_RS04630	COG0252	asparaginase activity
VI35_RS04635	COG3139	Protein of unknown function (DUF1315)
VI35_RS04655	COG0616	signal peptide processing
VI35_RS04660	COG0446	pyridine nucleotide-disulphide oxidoreductase
VI35_RS04660	COG1902	pentaerythritol trinitrate reductase activity
VI35_RS04665	COG0778	Nitroreductase
VI35_RS04680	COG2264	protein methyltransferase activity
VI35_RS04685	COG0604	alcohol dehydrogenase
VI35_RS04690	COG0583	DNA-binding transcription factor activity
VI35_RS04705	COG3924	membrane
VI35_RS04710	COG0439	Biotin carboxylase
VI35_RS04715	COG0511	ligase activity, forming carbon-carbon bonds
VI35_RS04720	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VI35_RS04725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VI35_RS04740	COG3381	protein complex oligomerization
VI35_RS04750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VI35_RS04760	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VI35_RS04765	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VI35_RS04765	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VI35_RS04780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VI35_RS04785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VI35_RS04795	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VI35_RS04800	COG4172	Belongs to the ABC transporter superfamily
VI35_RS04810	COG0601	transmembrane transport
VI35_RS04820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VI35_RS04825	COG0142	geranyltranstransferase activity
VI35_RS04835	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VI35_RS04855	COG1534	Rna-binding protein
VI35_RS04860	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VI35_RS04870	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VI35_RS04875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VI35_RS04880	COG0149	triose-phosphate isomerase activity
VI35_RS04885	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VI35_RS04900	COG0779	Required for maturation of 30S ribosomal subunits
VI35_RS04905	COG0195	Participates in both transcription termination and antitermination
VI35_RS04910	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VI35_RS04915	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VI35_RS04920	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VI35_RS04925	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VI35_RS04930	COG1185	polyribonucleotide nucleotidyltransferase activity
VI35_RS04935	COG2211	Major facilitator Superfamily
VI35_RS04940	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VI35_RS04945	COG1422	Protein of unknown function (DUF1090)
VI35_RS04955	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VI35_RS04960	COG0826	peptidase U32
VI35_RS04975	COG0312	modulator of DNA gyrase
VI35_RS04980	COG0312	modulator of DNA gyrase
VI35_RS04985	COG0312	modulator of DNA gyrase
VI35_RS04995	COG4974	Belongs to the 'phage' integrase family
VI35_RS05000	COG1970	mechanosensitive ion channel activity
VI35_RS05015	COG0789	Transcriptional regulator
VI35_RS05030	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VI35_RS05040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VI35_RS05050	COG0321	lipoyl(octanoyl) transferase activity
VI35_RS05055	COG2921	Belongs to the UPF0250 family
VI35_RS05060	COG1686	Belongs to the peptidase S11 family
VI35_RS05065	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VI35_RS05070	COG2951	lytic endotransglycosylase activity
VI35_RS05075	COG0772	Belongs to the SEDS family
VI35_RS05080	COG0768	penicillin binding
VI35_RS05085	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VI35_RS05090	COG0799	negative regulation of ribosome biogenesis
VI35_RS05095	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VI35_RS05115	COG0495	leucyl-tRNA aminoacylation
VI35_RS05120	COG2888	peptidyl-tyrosine sulfation
VI35_RS05125	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VI35_RS05130	COG4535	Mg2 and Co2 transporter CorC
VI35_RS05140	COG1702	phosphate starvation-inducible protein PhoH
VI35_RS05145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VI35_RS05150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VI35_RS05155	COG1335	isochorismatase
VI35_RS05195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VI35_RS05210	COG1464	Belongs to the NlpA lipoprotein family
VI35_RS05215	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VI35_RS05225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VI35_RS05235	COG0516	GMP reductase activity
VI35_RS05260	COG0300	oxidoreductase activity
VI35_RS05300	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VI35_RS05305	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VI35_RS05310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VI35_RS05315	COG1053	succinate dehydrogenase
VI35_RS05325	COG0584	glycerophosphoryl diester phosphodiesterase
VI35_RS05355	COG0583	DNA-binding transcription factor activity
VI35_RS05370	COG0583	DNA-binding transcription factor activity
VI35_RS05375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VI35_RS05405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VI35_RS05410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VI35_RS05420	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VI35_RS05425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VI35_RS05430	COG0546	phosphoglycolate phosphatase activity
VI35_RS05435	COG0180	Tryptophanyl-tRNA synthetase
VI35_RS05450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VI35_RS05460	COG1012	belongs to the aldehyde dehydrogenase family
VI35_RS05475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VI35_RS05485	COG1013	pyruvate-flavodoxin oxidoreductase activity
VI35_RS05485	COG0674	pyruvate-flavodoxin oxidoreductase activity
VI35_RS05485	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VI35_RS05485	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VI35_RS05510	COG0657	acetylesterase activity
VI35_RS05520	COG0471	metal ion transport
VI35_RS05520	COG0490	domain, Protein
VI35_RS05570	COG0012	GTP binding
VI35_RS05575	COG0193	aminoacyl-tRNA hydrolase activity
VI35_RS05580	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VI35_RS05590	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VI35_RS05595	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VI35_RS05600	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VI35_RS05605	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VI35_RS05610	COG2890	protein-(glutamine-N5) methyltransferase activity
VI35_RS05620	COG2912	Transglutaminase-like superfamily
VI35_RS05625	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VI35_RS05630	COG1301	dicarboxylic acid transport
VI35_RS05640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VI35_RS05655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VI35_RS05660	COG1115	amino acid carrier protein
VI35_RS05680	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VI35_RS05690	COG0189	ligase activity
VI35_RS05695	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VI35_RS05705	COG3091	SprT-like family
VI35_RS05715	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VI35_RS05725	COG2801	Transposase and inactivated derivatives
VI35_RS05745	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VI35_RS05750	COG0739	heme binding
VI35_RS05755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VI35_RS05765	COG1881	PFAM PEBP family protein
VI35_RS05770	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VI35_RS05775	COG0583	DNA-binding transcription factor activity
VI35_RS05785	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VI35_RS05795	COG0583	DNA-binding transcription factor activity
VI35_RS05800	COG1028	Short-chain dehydrogenase reductase Sdr
VI35_RS05805	COG0616	signal peptide processing
VI35_RS05810	COG3724	N-succinylarginine dihydrolase activity
VI35_RS05825	COG0840	transmembrane signaling receptor activity
VI35_RS05845	COG4608	Belongs to the ABC transporter superfamily
VI35_RS05850	COG0444	Belongs to the ABC transporter superfamily
VI35_RS05855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VI35_RS05885	COG0798	PFAM Bile acid sodium symporter
VI35_RS05890	COG1393	Belongs to the ArsC family
VI35_RS05900	COG1677	Flagellar hook-basal body complex protein FliE
VI35_RS05910	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VI35_RS05965	COG1684	flagellar biosynthetic protein fliR
VI35_RS05975	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VI35_RS06000	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VI35_RS06005	COG0784	Response regulator, receiver
VI35_RS06005	COG0643	Histidine kinase
VI35_RS06005	COG2198	Histidine kinase
VI35_RS06010	COG2201	protein-glutamate methylesterase activity
VI35_RS06015	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VI35_RS06020	COG1360	Flagellar Motor Protein
VI35_RS06025	COG1192	Involved in chromosome partitioning
VI35_RS06035	COG0835	chemotaxis
VI35_RS06055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VI35_RS06060	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VI35_RS06065	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VI35_RS06105	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VI35_RS06110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VI35_RS06110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VI35_RS06125	COG0259	pyridoxamine-phosphate oxidase activity
VI35_RS06155	COG3153	acetyltransferase
VI35_RS06170	COG0800	Aldolase
VI35_RS06175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VI35_RS06190	COG0246	Mannitol dehydrogenase
VI35_RS06225	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VI35_RS06230	COG2867	negative regulation of translational initiation
VI35_RS06235	COG2914	Belongs to the UPF0125 (RnfH) family
VI35_RS06240	COG0702	epimerase
VI35_RS06245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VI35_RS06250	COG1454	alcohol dehydrogenase
VI35_RS06260	COG0564	pseudouridine synthase activity
VI35_RS06265	COG1957	nucleoside hydrolase
VI35_RS06290	COG1280	lysine exporter protein (LysE YggA)
VI35_RS06310	COG1876	peptidase activity
VI35_RS06315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VI35_RS06320	COG1393	Belongs to the ArsC family
VI35_RS06345	COG3069	C4-dicarboxylate transmembrane transporter activity
VI35_RS06350	COG1473	amidohydrolase
VI35_RS06360	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VI35_RS06365	COG0017	Asparaginyl-tRNA synthetase
VI35_RS06385	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VI35_RS06395	COG1073	alpha beta
VI35_RS06395	COG2226	methyltransferase
VI35_RS06400	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VI35_RS06405	COG0501	Belongs to the peptidase M48B family
VI35_RS06425	COG2841	Protein conserved in bacteria
VI35_RS06435	COG0534	Mate efflux family protein
VI35_RS06460	COG1454	alcohol dehydrogenase
VI35_RS06470	COG1309	transcriptional regulator
VI35_RS06485	COG0791	NLP P60 protein
VI35_RS06490	COG0583	DNA-binding transcription factor activity
VI35_RS06510	COG0500	methyltransferase
VI35_RS06515	COG4106	trans-aconitate 2-methyltransferase activity
VI35_RS06520	COG1801	Protein of unknown function DUF72
VI35_RS06530	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VI35_RS06535	COG0217	transcriptional regulatory protein
VI35_RS06540	COG2194	sulfuric ester hydrolase activity
VI35_RS06545	COG1846	Transcriptional regulator
VI35_RS06545	COG1940	carbohydrate kinase activity
VI35_RS06550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VI35_RS06555	COG0363	glucosamine-6-phosphate deaminase activity
VI35_RS06560	COG1263	PTS System
VI35_RS06560	COG2190	(PTS) system
VI35_RS06560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VI35_RS06570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VI35_RS06575	COG0735	belongs to the Fur family
VI35_RS06585	COG0716	FMN binding
VI35_RS06605	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VI35_RS06610	COG0033	Phosphoglucomutase
VI35_RS06620	COG1846	Transcriptional regulator
VI35_RS06625	COG2951	lytic endotransglycosylase activity
VI35_RS06630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VI35_RS06655	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VI35_RS06665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VI35_RS06700	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VI35_RS06725	COG1607	acyl-coa hydrolase
VI35_RS06740	COG1388	LysM domain
VI35_RS06740	COG0741	lytic transglycosylase activity
VI35_RS06745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VI35_RS06750	COG2226	methyltransferase
VI35_RS06755	COG0328	RNA-DNA hybrid ribonuclease activity
VI35_RS06760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VI35_RS06770	COG3437	response regulator, receiver
VI35_RS06770	COG0784	Response regulator, receiver
VI35_RS06775	COG1960	acyl-CoA dehydrogenase activity
VI35_RS06780	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VI35_RS06785	COG0121	glutamine amidotransferase
VI35_RS06795	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VI35_RS06820	COG2197	response regulator
VI35_RS06825	COG3850	Histidine kinase
VI35_RS06835	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
VI35_RS06835	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VI35_RS06845	COG0243	molybdopterin cofactor binding
VI35_RS06850	COG0437	4 iron, 4 sulfur cluster binding
VI35_RS06865	COG3005	denitrification pathway
VI35_RS06870	COG0521	Mo-molybdopterin cofactor biosynthetic process
VI35_RS06875	COG0315	cyclic pyranopterin monophosphate synthase activity
VI35_RS06880	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VI35_RS06885	COG0314	molybdopterin synthase activity
VI35_RS06905	COG2267	carboxylic ester hydrolase activity
VI35_RS06920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VI35_RS06930	COG0302	gtp cyclohydrolase
VI35_RS06935	COG0840	transmembrane signaling receptor activity
VI35_RS06940	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VI35_RS06950	COG0583	DNA-binding transcription factor activity
VI35_RS06965	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
VI35_RS06980	COG2195	Cleaves the N-terminal amino acid of tripeptides
VI35_RS06995	COG1166	arginine decarboxylase activity
VI35_RS07025	COG4191	Histidine kinase
VI35_RS07045	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
VI35_RS07065	COG0583	DNA-binding transcription factor activity
VI35_RS07095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VI35_RS07105	COG1294	oxidase, subunit
VI35_RS07115	COG2814	Major facilitator Superfamily
VI35_RS07120	COG0656	L-ascorbic acid biosynthetic process
VI35_RS07140	COG0583	DNA-binding transcription factor activity
VI35_RS07145	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VI35_RS07150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VI35_RS07155	COG2271	Major facilitator Superfamily
VI35_RS07160	COG1349	DNA-binding transcription factor activity
VI35_RS07170	COG0584	glycerophosphoryl diester phosphodiesterase
VI35_RS07175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VI35_RS07180	COG0287	Prephenate dehydrogenase
VI35_RS07180	COG1605	Chorismate mutase
VI35_RS07190	COG3085	chromosome segregation
VI35_RS07195	COG4574	serine-type endopeptidase inhibitor activity
VI35_RS07220	COG4771	TonB-dependent receptor
VI35_RS07225	COG3083	sulfuric ester hydrolase activity
VI35_RS07230	COG3082	Protein of unknown function (DUF1414)
VI35_RS07245	COG1175	transmembrane transport
VI35_RS07250	COG3833	ABC-type maltose transport systems, permease component
VI35_RS07280	COG0425	Belongs to the sulfur carrier protein TusA family
VI35_RS07285	COG4783	chaperone-mediated protein folding
VI35_RS07295	COG1393	Belongs to the ArsC family
VI35_RS07320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VI35_RS07340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VI35_RS07350	COG4160	amino acid transport
VI35_RS07360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VI35_RS07385	COG1566	PFAM secretion protein HlyD family protein
VI35_RS07395	COG0628	permease
VI35_RS07405	COG4953	penicillin-binding protein 1C
VI35_RS07415	COG0301	tRNA thio-modification
VI35_RS07415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VI35_RS07430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VI35_RS07435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VI35_RS07470	COG2089	acid synthase
VI35_RS07495	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
VI35_RS07505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VI35_RS07510	COG1086	Polysaccharide biosynthesis protein
VI35_RS07515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VI35_RS07525	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VI35_RS07550	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VI35_RS07560	COG4659	FMN binding
VI35_RS07565	COG4658	electron transport chain
VI35_RS07575	COG2878	Part of a membrane complex involved in electron transport
VI35_RS07580	COG4657	Part of a membrane complex involved in electron transport
VI35_RS07585	COG0697	spore germination
VI35_RS07605	COG1288	antiporter activity
VI35_RS07610	COG0436	Aminotransferase
VI35_RS07620	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VI35_RS07625	COG2027	D-alanyl-D-alanine carboxypeptidase
VI35_RS07635	COG1566	PFAM secretion protein HlyD family protein
VI35_RS07650	COG1966	Carbon starvation protein
VI35_RS07655	COG3279	Response regulator of the LytR AlgR family
VI35_RS07660	COG3275	phosphorelay sensor kinase activity
VI35_RS07675	COG2095	MarC family integral membrane protein
VI35_RS07685	COG0601	transmembrane transport
VI35_RS07690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VI35_RS07695	COG0444	Belongs to the ABC transporter superfamily
VI35_RS07705	COG0861	Integral membrane protein TerC family
VI35_RS07710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VI35_RS07720	COG1301	dicarboxylic acid transport
VI35_RS07735	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
VI35_RS07740	COG0582	viral genome integration into host DNA
VI35_RS07790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VI35_RS07810	COG1396	sequence-specific DNA binding
VI35_RS07885	COG1403	HNH endonuclease
VI35_RS07935	COG2801	Transposase and inactivated derivatives
VI35_RS08025	COG2801	Transposase and inactivated derivatives
VI35_RS08045	COG0537	adenosine 5'-monophosphoramidase activity
VI35_RS08085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VI35_RS08110	COG1164	Oligoendopeptidase f
VI35_RS08115	COG3150	esterase
VI35_RS08120	COG1252	NADH dehydrogenase
VI35_RS08125	COG0393	Putative heavy-metal-binding
VI35_RS08130	COG1619	proteins homologs of microcin C7 resistance protein MccF
VI35_RS08145	COG0527	aspartate kinase activity
VI35_RS08150	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VI35_RS08150	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VI35_RS08155	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VI35_RS08190	COG0247	lactate metabolic process
VI35_RS08195	COG1139	Iron-sulfur cluster binding protein
VI35_RS08230	COG0577	efflux transmembrane transporter activity
VI35_RS08235	COG1136	(ABC) transporter
VI35_RS08280	COG0672	)-iron permease
VI35_RS08355	COG3501	Rhs element vgr protein
VI35_RS08365	COG3209	COG3209 Rhs family protein
VI35_RS08565	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
VI35_RS08570	COG0437	4 iron, 4 sulfur cluster binding
VI35_RS08575	COG5557	Pfam Polysulphide reductase, NrfD
VI35_RS08585	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
VI35_RS08590	COG1773	rubredoxin
VI35_RS08595	COG0747	negative chemotaxis
VI35_RS08600	COG0601	transmembrane transport
VI35_RS08615	COG1124	(ABC) transporter
VI35_RS08630	COG0375	protein maturation
VI35_RS08645	COG0298	carbon dioxide binding
VI35_RS08650	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
VI35_RS08655	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VI35_RS08660	COG0326	Molecular chaperone. Has ATPase activity
VI35_RS08665	COG0563	adenylate kinase activity
VI35_RS08670	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VI35_RS08675	COG3788	relative of glutathione S-transferase, MAPEG superfamily
VI35_RS08685	COG0840	transmembrane signaling receptor activity
VI35_RS08725	COG1021	2,3-dihydroxybenzoate-AMP ligase
VI35_RS08730	COG1535	isochorismatase
VI35_RS08730	COG3433	isochorismatase activity
VI35_RS08740	COG1028	Short-chain dehydrogenase reductase Sdr
VI35_RS08750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VI35_RS08765	COG1120	ATPase activity
VI35_RS08770	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VI35_RS08775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VI35_RS08780	COG4771	TonB-dependent receptor
VI35_RS08825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VI35_RS08835	COG0861	Integral membrane protein TerC family
VI35_RS08850	COG1022	Amp-dependent synthetase and ligase
VI35_RS08855	COG0295	cytidine deaminase activity
VI35_RS08860	COG1346	cytolysis
VI35_RS08865	COG1380	Effector of murein hydrolase LrgA
VI35_RS08880	COG2925	Exonuclease
VI35_RS08885	COG0582	viral genome integration into host DNA
VI35_RS08945	COG1846	Transcriptional regulator
VI35_RS08990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VI35_RS08995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VI35_RS09000	COG2135	peptidase activity
VI35_RS09030	COG4220	transposase activity
VI35_RS09050	COG0740	serine-type endopeptidase activity
VI35_RS09160	COG0667	Aldo Keto reductase
VI35_RS09170	COG4221	oxidoreductase activity
VI35_RS09175	COG1028	Short-chain dehydrogenase reductase Sdr
VI35_RS09180	COG3321	synthase
VI35_RS09180	COG0604	alcohol dehydrogenase
VI35_RS09185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VI35_RS09205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VI35_RS09210	COG1028	Short-chain dehydrogenase reductase Sdr
VI35_RS09240	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VI35_RS09245	COG1085	galactose-1-phosphate uridylyltransferase
VI35_RS09260	COG4580	involved in the transport of maltose and maltodextrins
VI35_RS09285	COG2182	Extracellular solute-binding protein
VI35_RS09290	COG1175	transmembrane transport
VI35_RS09295	COG3833	ABC-type maltose transport systems, permease component
VI35_RS09300	COG3867	Arabinogalactan endo-beta-1,4-galactanase
VI35_RS09305	COG1874	Beta-galactosidase
VI35_RS09310	COG1263	PTS System
VI35_RS09310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VI35_RS09340	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VI35_RS09360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VI35_RS09365	COG0436	Aminotransferase
VI35_RS09385	COG1069	ribulokinase activity
VI35_RS09390	COG1879	ABC-type sugar transport system periplasmic component
VI35_RS09395	COG1129	ABC transporter
VI35_RS09400	COG1172	Belongs to the binding-protein-dependent transport system permease family
VI35_RS09410	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VI35_RS09430	COG1451	nucleotide metabolic process
VI35_RS09445	COG3069	C4-dicarboxylate transmembrane transporter activity
VI35_RS09455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VI35_RS09455	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VI35_RS09460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VI35_RS09480	COG2009	succinate dehydrogenase
VI35_RS09485	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VI35_RS09500	COG0567	Dehydrogenase, E1 component
VI35_RS09505	COG0508	dehydrogenase complex catalyzes the overall conversion of
VI35_RS09515	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VI35_RS09530	COG2983	Belongs to the UPF0260 family
VI35_RS09535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VI35_RS09545	COG3842	ATPase activity
VI35_RS09550	COG1840	ABC-type Fe3 transport system, periplasmic component
VI35_RS09560	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VI35_RS09565	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VI35_RS09570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VI35_RS09575	COG1882	Formate acetyltransferase
VI35_RS09580	COG2116	formate transmembrane transporter activity
VI35_RS09600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VI35_RS09605	COG1278	Cold shock
VI35_RS09610	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VI35_RS09615	COG0542	response to heat
VI35_RS09620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VI35_RS09630	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VI35_RS09635	COG3134	Outer membrane lipoprotein
VI35_RS09640	COG3706	GGDEF domain
VI35_RS09645	COG0492	ferredoxin-NADP+ reductase activity
VI35_RS09650	COG0686	Belongs to the AlaDH PNT family
VI35_RS09665	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VI35_RS09675	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VI35_RS09680	COG1286	toxin biosynthetic process
VI35_RS09685	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VI35_RS09690	COG2723	6-phospho-beta-galactosidase activity
VI35_RS09695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VI35_RS09695	COG1263	PTS System
VI35_RS09700	COG1609	Transcriptional regulator
VI35_RS09710	COG4172	Belongs to the ABC transporter superfamily
VI35_RS09720	COG4171	peptide transport system, permease
VI35_RS09740	COG1842	Phage shock protein A
VI35_RS09755	COG3106	COG3106 Predicted ATPase
VI35_RS09760	COG3768	UPF0283 membrane protein
VI35_RS09770	COG2154	pterin-4-alpha-carbinolamine dehydratase
VI35_RS09790	COG2885	chlorophyll binding
VI35_RS09800	COG1570	exodeoxyribonuclease VII activity
VI35_RS09810	COG1874	Beta-galactosidase
VI35_RS09810	COG0366	Alpha amylase catalytic
VI35_RS09820	COG0516	GMP reductase activity
VI35_RS09820	COG0517	IMP dehydrogenase activity
VI35_RS09825	COG0519	Catalyzes the synthesis of GMP from XMP
VI35_RS09825	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VI35_RS09855	COG1846	Transcriptional regulator
VI35_RS09875	COG2062	phosphohistidine phosphatase, SixA
VI35_RS09885	COG0697	spore germination
VI35_RS09895	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VI35_RS09900	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VI35_RS09910	COG4591	ABC-type transport system involved in lipoprotein release permease component
VI35_RS09915	COG1136	(ABC) transporter
VI35_RS09920	COG4591	ABC-type transport system involved in lipoprotein release permease component
VI35_RS09925	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VI35_RS09940	COG0544	peptidyl-prolyl cis-trans isomerase activity
VI35_RS09945	COG0740	serine-type endopeptidase activity
VI35_RS09950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VI35_RS09955	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VI35_RS09960	COG0776	regulation of translation
VI35_RS09965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VI35_RS09970	COG0488	(ABC) transporter
VI35_RS09975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VI35_RS09980	COG3162	membrane
VI35_RS10000	COG1115	amino acid carrier protein
VI35_RS10010	COG3228	Belongs to the MtfA family
VI35_RS10015	COG1584	GPR1 FUN34 yaaH family protein
VI35_RS10040	COG1024	Enoyl-CoA hydratase
VI35_RS10050	COG1960	acyl-CoA dehydrogenase activity
VI35_RS10060	COG1960	acyl-CoA dehydrogenase activity
VI35_RS10070	COG1024	Enoyl-CoA hydratase
VI35_RS10090	COG0730	response to heat
VI35_RS10105	COG1172	Belongs to the binding-protein-dependent transport system permease family
VI35_RS10115	COG1129	ABC transporter
VI35_RS10120	COG1879	ABC-type sugar transport system periplasmic component
VI35_RS10125	COG0583	DNA-binding transcription factor activity
VI35_RS10140	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VI35_RS10145	COG0243	molybdopterin cofactor binding
VI35_RS10155	COG0583	DNA-binding transcription factor activity
VI35_RS10160	COG2723	6-phospho-beta-galactosidase activity
VI35_RS10170	COG0583	DNA-binding transcription factor activity
VI35_RS10185	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VI35_RS10205	COG1560	Kdo2-lipid A biosynthetic process
VI35_RS10210	COG1560	Kdo2-lipid A biosynthetic process
VI35_RS10225	COG0417	DNA replication proofreading
VI35_RS10255	COG0534	Mate efflux family protein
VI35_RS10265	COG0307	riboflavin synthase, alpha
VI35_RS10280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VI35_RS10290	COG0697	spore germination
VI35_RS10295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VI35_RS10340	COG3099	Belongs to the UPF0263 family
VI35_RS10350	COG2894	cell division
VI35_RS10360	COG3100	YcgL domain-containing protein
VI35_RS10365	COG2951	lytic endotransglycosylase activity
VI35_RS10370	COG1760	l-serine dehydratase
VI35_RS10380	COG1760	l-serine dehydratase
VI35_RS10385	COG3123	guanosine phosphorylase activity
VI35_RS10390	COG1301	dicarboxylic acid transport
VI35_RS10405	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VI35_RS10410	COG2067	long-chain fatty acid transport protein
VI35_RS10420	COG2067	long-chain fatty acid transport protein
VI35_RS10460	COG0714	Associated with various cellular activities
VI35_RS10465	COG0183	Belongs to the thiolase family
VI35_RS10480	COG4681	YaeQ
VI35_RS10505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VI35_RS10520	COG3134	Outer membrane lipoprotein
VI35_RS10530	COG0318	PFAM AMP-dependent synthetase and ligase
VI35_RS10535	COG2378	regulation of single-species biofilm formation
VI35_RS10545	COG0140	phosphoribosyl-ATP diphosphatase activity
VI35_RS10545	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VI35_RS10560	COG2199	diguanylate cyclase activity
VI35_RS10565	COG3437	response regulator, receiver
VI35_RS10570	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VI35_RS10575	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VI35_RS10580	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VI35_RS10580	COG0131	Imidazoleglycerol-phosphate dehydratase
VI35_RS10585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VI35_RS10590	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VI35_RS10610	COG1214	PFAM Peptidase M22, glycoprotease
VI35_RS10625	COG0318	PFAM AMP-dependent synthetase and ligase
VI35_RS10640	COG0697	spore germination
VI35_RS10650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VI35_RS10655	COG2832	Protein of unknown function (DUF454)
VI35_RS10660	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VI35_RS10670	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VI35_RS10675	COG0583	DNA-binding transcription factor activity
VI35_RS10685	COG3314	Sporulation integral membrane protein YlbJ
VI35_RS10690	COG2197	response regulator
VI35_RS10695	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VI35_RS10695	COG0617	tRNA 3'-terminal CCA addition
VI35_RS10695	COG0517	IMP dehydrogenase activity
VI35_RS10700	COG1643	Atp-dependent helicase
VI35_RS10710	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VI35_RS10720	COG3437	response regulator, receiver
VI35_RS10730	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
VI35_RS10735	COG0709	Synthesizes selenophosphate from selenide and ATP
VI35_RS10750	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VI35_RS10755	COG0840	transmembrane signaling receptor activity
VI35_RS10760	COG1254	Belongs to the acylphosphatase family
VI35_RS10770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VI35_RS10770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VI35_RS10775	COG0489	protein tyrosine kinase activity
VI35_RS10780	COG0572	uridine kinase
VI35_RS10785	COG0717	Belongs to the dCTP deaminase family
VI35_RS10795	COG1530	ribonuclease E activity
VI35_RS10800	COG0564	pseudouridine synthase activity
VI35_RS10815	COG1399	metal-binding, possibly nucleic acid-binding protein
VI35_RS10820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VI35_RS10825	COG0416	fatty acid biosynthetic process
VI35_RS10830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VI35_RS10840	COG1028	Short-chain dehydrogenase reductase Sdr
VI35_RS10845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VI35_RS10855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VI35_RS10860	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VI35_RS10865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VI35_RS10870	COG0470	DNA polymerase III
VI35_RS10875	COG0084	hydrolase, TatD family'
VI35_RS10890	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VI35_RS10890	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VI35_RS10900	COG2995	paraquat-inducible protein a
VI35_RS10920	COG1067	ATP-dependent peptidase activity
VI35_RS10925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VI35_RS10940	COG0488	(ABC) transporter
VI35_RS10950	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VI35_RS10950	COG0116	Belongs to the methyltransferase superfamily
VI35_RS10960	COG0167	dihydroorotate dehydrogenase activity
VI35_RS10965	COG2902	Dehydrogenase
VI35_RS10975	COG0308	aminopeptidase N
VI35_RS10985	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VI35_RS10990	COG1956	GAF domain-containing protein
VI35_RS11005	COG3278	Belongs to the heme-copper respiratory oxidase family
VI35_RS11020	COG2010	Cytochrome c
VI35_RS11050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VI35_RS11055	COG0589	response to stress
VI35_RS11060	COG0037	tRNA processing
VI35_RS11075	COG0625	glutathione transferase activity
VI35_RS11080	COG1869	D-ribose catabolic process
VI35_RS11085	COG1129	ABC transporter
VI35_RS11090	COG1172	Belongs to the binding-protein-dependent transport system permease family
VI35_RS11095	COG1879	ABC-type sugar transport system periplasmic component
VI35_RS11100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VI35_RS11105	COG1609	Transcriptional regulator
VI35_RS11110	COG5001	Diguanylate cyclase
VI35_RS11110	COG3300	MHYT domain
VI35_RS11145	COG0072	phenylalanine-tRNA ligase activity
VI35_RS11145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VI35_RS11150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VI35_RS11155	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VI35_RS11160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VI35_RS11165	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
VI35_RS11170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VI35_RS11205	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VI35_RS11210	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VI35_RS11220	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VI35_RS11225	COG3313	Fe-S protein
VI35_RS11230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VI35_RS11230	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VI35_RS11230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VI35_RS11235	COG1105	Belongs to the carbohydrate kinase PfkB family
VI35_RS11245	COG1609	Transcriptional regulator
VI35_RS11250	COG0814	amino acid
VI35_RS11260	COG5654	RES domain protein
VI35_RS11265	COG0513	Belongs to the DEAD box helicase family
VI35_RS11275	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VI35_RS11280	COG2890	protein-(glutamine-N5) methyltransferase activity
VI35_RS11320	COG2824	Alkylphosphonate utilization operon protein PhnA
VI35_RS11330	COG1280	lysine exporter protein (LysE YggA)
VI35_RS11375	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VI35_RS11380	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VI35_RS11390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VI35_RS11395	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VI35_RS11405	COG0205	6-phosphofructokinase activity
VI35_RS11415	COG1011	Hydrolase
VI35_RS11475	COG0583	DNA-binding transcription factor activity
VI35_RS11480	COG0730	response to heat
VI35_RS11485	COG3148	PFAM DTW domain containing protein
VI35_RS11490	COG1181	Belongs to the D-alanine--D-alanine ligase family
VI35_RS11500	COG0386	Belongs to the glutathione peroxidase family
VI35_RS11505	COG0513	Belongs to the DEAD box helicase family
VI35_RS11545	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VI35_RS11570	COG3243	poly(R)-hydroxyalkanoic acid synthase
VI35_RS11580	COG2501	S4 domain
VI35_RS11635	COG0058	SHG alpha-glucan phosphorylase activity
VI35_RS11665	COG0814	amino acid
VI35_RS11670	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VI35_RS11675	COG0514	ATP-dependent DNA helicase (RecQ)
VI35_RS11680	COG2766	serine protein kinase
VI35_RS11685	COG2718	Belongs to the UPF0229 family
VI35_RS11690	COG2719	SpoVR family
VI35_RS11695	COG2186	Transcriptional regulator
VI35_RS11700	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VI35_RS11705	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VI35_RS11710	COG0586	Pfam SNARE associated Golgi protein
VI35_RS11735	COG2985	domain, Protein
VI35_RS11735	COG0569	domain protein
VI35_RS11740	COG1196	nuclear chromosome segregation
VI35_RS11740	COG0739	heme binding
VI35_RS11740	COG0741	lytic transglycosylase activity
VI35_RS11745	COG3181	Tripartite tricarboxylate transporter family receptor
VI35_RS11760	COG4565	transcriptional regulatory protein
VI35_RS11765	COG3290	protein histidine kinase activity
VI35_RS11775	COG0840	transmembrane signaling receptor activity
VI35_RS11780	COG3012	SEC-C Motif Domain Protein
VI35_RS11785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VI35_RS11790	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
VI35_RS11795	COG0247	lactate metabolic process
VI35_RS11820	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VI35_RS11825	COG0437	4 iron, 4 sulfur cluster binding
VI35_RS11830	COG3301	Polysulphide reductase, NrfD
VI35_RS11860	COG3046	protein related to deoxyribodipyrimidine photolyase
VI35_RS11865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VI35_RS11880	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VI35_RS11880	COG0617	tRNA 3'-terminal CCA addition
VI35_RS11880	COG0517	IMP dehydrogenase activity
VI35_RS11890	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VI35_RS11895	COG0583	DNA-binding transcription factor activity
VI35_RS11905	COG4774	siderophore transport
VI35_RS11915	COG3706	GGDEF domain
VI35_RS11920	COG4251	negative regulation of phosphorylation
VI35_RS11920	COG2203	Gaf domain
VI35_RS11920	COG5001	Diguanylate cyclase
VI35_RS11920	COG3706	GGDEF domain
VI35_RS11925	COG2200	EAL domain
VI35_RS11925	COG2771	luxR family
VI35_RS11940	COG2910	NAD(P)H-binding
VI35_RS11975	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VI35_RS11990	COG2723	6-phospho-beta-galactosidase activity
VI35_RS11995	COG2190	(PTS) system
VI35_RS11995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VI35_RS11995	COG1263	PTS System
VI35_RS12000	COG1737	Transcriptional regulator
VI35_RS12025	COG1435	thymidine kinase activity
VI35_RS12035	COG2916	Histone family protein nucleoid-structuring protein H-NS
VI35_RS12040	COG2096	Adenosyltransferase
VI35_RS12045	COG3530	Putative quorum-sensing-regulated virulence factor
VI35_RS12050	COG0602	queuosine metabolic process
VI35_RS12055	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VI35_RS12075	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VI35_RS12085	COG0776	regulation of translation
VI35_RS12090	COG0539	negative regulation of cytoplasmic translation
VI35_RS12095	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VI35_RS12100	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VI35_RS12125	COG0778	Nitroreductase
VI35_RS12130	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VI35_RS12135	COG5001	Diguanylate cyclase
VI35_RS12135	COG3300	MHYT domain
VI35_RS12145	COG0583	DNA-binding transcription factor activity
VI35_RS12150	COG0745	RESPONSE REGULATOR receiver
VI35_RS12175	COG4989	oxidoreductase activity
VI35_RS12180	COG0724	RNA recognition motif
VI35_RS12200	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
VI35_RS12215	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VI35_RS12220	COG1360	Flagellar Motor Protein
VI35_RS12225	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VI35_RS12230	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VI35_RS12235	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VI35_RS12235	COG0649	NAD binding
VI35_RS12255	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
VI35_RS12260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VI35_RS12265	COG0839	Belongs to the complex I subunit 6 family
VI35_RS12270	COG0713	ATP synthesis coupled electron transport
VI35_RS12280	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VI35_RS12285	COG1007	ATP synthesis coupled electron transport
VI35_RS12290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VI35_RS12290	COG0047	phosphoribosylformylglycinamidine synthase activity
VI35_RS12295	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VI35_RS12300	COG1645	bacterial-type flagellum-dependent swarming motility
VI35_RS12305	COG1160	GTP binding
VI35_RS12310	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VI35_RS12315	COG2976	Protein conserved in bacteria
VI35_RS12320	COG0124	histidyl-tRNA synthetase
VI35_RS12330	COG1426	Protein conserved in bacteria
VI35_RS12340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VI35_RS12345	COG0105	UTP biosynthetic process
VI35_RS12360	COG0633	Ferredoxin
VI35_RS12365	COG0443	Heat shock 70 kDa protein
VI35_RS12370	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VI35_RS12380	COG0822	iron-sulfur transferase activity
VI35_RS12385	COG1104	cysteine desulfurase activity
VI35_RS12400	COG3154	lipid carrier protein
VI35_RS12405	COG0826	peptidase U32
VI35_RS12410	COG0826	peptidase U32
VI35_RS12420	COG2897	thiosulfate sulfurtransferase activity
VI35_RS12425	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VI35_RS12430	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VI35_RS12435	COG1862	Preprotein translocase
VI35_RS12445	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VI35_RS12450	COG0517	IMP dehydrogenase activity
VI35_RS12455	COG0450	alkyl hydroperoxide reductase
VI35_RS12460	COG3634	alkyl hydroperoxide reductase activity
VI35_RS12495	COG0509	glycine decarboxylation via glycine cleavage system
VI35_RS12500	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VI35_RS12505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VI35_RS12510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VI35_RS12530	COG2814	Major facilitator Superfamily
VI35_RS12540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VI35_RS12545	COG0601	transmembrane transport
VI35_RS12555	COG0625	glutathione transferase activity
VI35_RS12560	COG0625	glutathione transferase activity
VI35_RS12580	COG3423	Transcriptional regulator
VI35_RS12610	COG0483	inositol monophosphate 1-phosphatase activity
VI35_RS12625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VI35_RS12630	COG2056	Na+-H+ antiporter family
VI35_RS12635	COG2814	Major facilitator Superfamily
VI35_RS12640	COG0583	DNA-binding transcription factor activity
VI35_RS12645	COG5001	Diguanylate cyclase
VI35_RS12660	COG2050	protein possibly involved in aromatic compounds catabolism
VI35_RS12685	COG1253	flavin adenine dinucleotide binding
VI35_RS12690	COG1902	pentaerythritol trinitrate reductase activity
VI35_RS12700	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VI35_RS12705	COG0647	UMP catabolic process
VI35_RS12715	COG0367	asparagine synthase
VI35_RS12725	COG0625	glutathione transferase activity
VI35_RS12735	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VI35_RS12750	COG0564	pseudouridine synthase activity
VI35_RS12755	COG5001	Diguanylate cyclase
VI35_RS12765	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VI35_RS12805	COG0670	Belongs to the BI1 family
VI35_RS12810	COG1289	transmembrane transporter activity
VI35_RS12815	COG2920	part of a sulfur-relay system
VI35_RS12820	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VI35_RS12835	COG0101	tRNA pseudouridine synthase activity
VI35_RS12845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VI35_RS12850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VI35_RS12860	COG1464	Belongs to the NlpA lipoprotein family
VI35_RS12895	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VI35_RS12905	COG1113	amino acid transport
VI35_RS12910	COG0582	viral genome integration into host DNA
VI35_RS12970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VI35_RS12980	COG0596	Alpha beta hydrolase
VI35_RS13065	COG1242	4 iron, 4 sulfur cluster binding
VI35_RS13070	COG0067	glutamate synthase
VI35_RS13070	COG0070	glutamate synthase
VI35_RS13070	COG0069	glutamate synthase activity
VI35_RS13075	COG0493	'glutamate synthase
VI35_RS13080	COG1126	abc transporter atp-binding protein
VI35_RS13085	COG0765	amino acid transport
VI35_RS13090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VI35_RS13115	COG4104	PAAR repeat-containing protein
VI35_RS13125	COG0513	Belongs to the DEAD box helicase family
VI35_RS13155	COG3706	GGDEF domain
VI35_RS13160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VI35_RS13170	COG0505	Belongs to the CarA family
VI35_RS13175	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VI35_RS13195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VI35_RS13200	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VI35_RS13205	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VI35_RS13240	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
VI35_RS13250	COG0023	Translation Initiation Factor
VI35_RS13255	COG2119	membrane
VI35_RS13315	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VI35_RS13325	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VI35_RS13330	COG2261	transglycosylase associated protein
VI35_RS13335	COG1309	transcriptional regulator
VI35_RS13355	COG0583	DNA-binding transcription factor activity
VI35_RS13380	COG0322	excinuclease ABC activity
VI35_RS13385	COG2197	response regulator
VI35_RS13390	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VI35_RS13395	COG2835	tetraacyldisaccharide 4'-kinase activity
VI35_RS13405	COG1132	(ABC) transporter
VI35_RS13425	COG0433	COG0433 Predicted ATPase
VI35_RS13430	COG1448	Aminotransferase
VI35_RS13445	COG1199	ATP-dependent helicase activity
VI35_RS13460	COG0477	Major facilitator Superfamily
VI35_RS13470	COG1785	Belongs to the alkaline phosphatase family
VI35_RS13490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VI35_RS13500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VI35_RS13505	COG0765	amino acid transport
VI35_RS13510	COG1126	abc transporter atp-binding protein
VI35_RS13520	COG0531	amino acid
VI35_RS13535	COG1253	flavin adenine dinucleotide binding
VI35_RS13540	COG0704	Plays a role in the regulation of phosphate uptake
VI35_RS13545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VI35_RS13550	COG0581	inorganic phosphate transmembrane transporter activity
VI35_RS13560	COG0590	tRNA wobble adenosine to inosine editing
VI35_RS13590	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VI35_RS13595	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VI35_RS13600	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VI35_RS13605	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VI35_RS13640	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VI35_RS13650	COG2239	Acts as a magnesium transporter
VI35_RS13665	COG3951	Flagellar rod assembly protein muramidase FlgJ
VI35_RS13665	COG1705	Flagellar rod assembly protein muramidase FlgJ
VI35_RS13675	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VI35_RS13690	COG1749	Flagellar hook protein flgE
VI35_RS13705	COG1815	bacterial-type flagellum-dependent cell motility
VI35_RS13710	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VI35_RS13715	COG0835	chemotaxis
VI35_RS13715	COG0784	Response regulator, receiver
VI35_RS13720	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
VI35_RS13735	COG0622	Phosphoesterase
VI35_RS13740	COG4166	transmembrane transport
VI35_RS13755	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VI35_RS13765	COG0697	spore germination
VI35_RS13770	COG4166	transmembrane transport
VI35_RS13795	COG1278	Cold shock
VI35_RS13810	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
VI35_RS13835	COG3132	Protein of unknown function, DUF480
VI35_RS13865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VI35_RS13890	COG2244	polysaccharide biosynthetic process
VI35_RS13900	COG1028	Short-chain dehydrogenase reductase Sdr
VI35_RS13905	COG1083	cytidylyl-transferase
VI35_RS13910	COG0673	inositol 2-dehydrogenase activity
VI35_RS13925	COG2089	acid synthase
VI35_RS13930	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VI35_RS13935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VI35_RS13945	COG1088	dTDP-glucose 4,6-dehydratase activity
VI35_RS13965	COG1737	Transcriptional regulator
VI35_RS13970	COG0469	pyruvate kinase activity
VI35_RS13980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VI35_RS13985	COG1960	acyl-CoA dehydrogenase activity
VI35_RS14020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VI35_RS14040	COG1946	Acyl-CoA thioesterase
VI35_RS14055	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
VI35_RS14065	COG0009	L-threonylcarbamoyladenylate synthase
VI35_RS14075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VI35_RS14080	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VI35_RS14080	COG0512	Glutamine amidotransferase of anthranilate synthase
VI35_RS14085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VI35_RS14090	COG0135	phosphoribosylanthranilate isomerase activity
VI35_RS14090	COG0134	indole-3-glycerol-phosphate synthase activity
VI35_RS14095	COG0133	tryptophan synthase activity
VI35_RS14100	COG0159	tryptophan synthase activity
VI35_RS14115	COG1396	sequence-specific DNA binding
VI35_RS14120	COG3550	peptidyl-serine autophosphorylation
VI35_RS14150	COG4521	taurine ABC transporter
VI35_RS14155	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
VI35_RS14160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VI35_RS14170	COG5507	3-demethylubiquinone-9 3-methyltransferase
VI35_RS14175	COG2814	Major facilitator Superfamily
VI35_RS14180	COG0109	protoheme IX farnesyltransferase activity
VI35_RS14185	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
VI35_RS14190	COG1845	cytochrome c oxidase, subunit III
VI35_RS14200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VI35_RS14205	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VI35_RS14210	COG0583	DNA-binding transcription factor activity
VI35_RS14230	COG1846	Transcriptional regulator
VI35_RS14245	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
VI35_RS14260	COG0745	RESPONSE REGULATOR receiver
VI35_RS14280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VI35_RS14285	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VI35_RS14320	COG2391	methyltransferase activity
VI35_RS14330	COG0640	Transcriptional regulator
VI35_RS14350	COG1285	pathogenesis
VI35_RS14380	COG0484	heat shock protein binding
VI35_RS14385	COG0443	Heat shock 70 kDa protein
VI35_RS14390	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VI35_RS14395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VI35_RS14415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VI35_RS14425	COG1538	Outer membrane efflux protein
VI35_RS14430	COG2375	cellular response to nickel ion
VI35_RS14435	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VI35_RS14440	COG2916	Histone family protein nucleoid-structuring protein H-NS
VI35_RS14445	COG0583	DNA-binding transcription factor activity
VI35_RS14495	COG0456	acetyltransferase
VI35_RS14500	COG1187	pseudouridine synthase activity
VI35_RS14510	COG0482	sulfurtransferase activity
VI35_RS14515	COG2915	High frequency lysogenization protein hflD homolog
VI35_RS14520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VI35_RS14535	COG1196	nuclear chromosome segregation
VI35_RS14535	COG3264	Mechanosensitive ion channel
VI35_RS14565	COG0281	malic enzyme
VI35_RS14570	COG0746	molybdenum cofactor guanylyltransferase activity
VI35_RS14575	COG1763	Mo-molybdopterin cofactor biosynthetic process
VI35_RS14580	COG1289	transmembrane transporter activity
VI35_RS14585	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VI35_RS14625	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VI35_RS14645	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VI35_RS14650	COG0083	homoserine kinase activity
VI35_RS14665	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VI35_RS14670	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
VI35_RS14695	COG0745	RESPONSE REGULATOR receiver
VI35_RS14715	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VI35_RS14735	COG1720	tRNA m6t6A37 methyltransferase activity
VI35_RS14750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VI35_RS14755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VI35_RS14760	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VI35_RS14770	COG2190	(PTS) system
VI35_RS14785	COG0420	3'-5' exonuclease activity
VI35_RS14805	COG0405	Gamma-glutamyltransferase
VI35_RS14810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VI35_RS14810	COG4651	solute:proton antiporter activity
VI35_RS14850	COG1396	sequence-specific DNA binding
VI35_RS14850	COG1917	Cupin 2, conserved barrel domain protein
VI35_RS14855	COG1012	belongs to the aldehyde dehydrogenase family
VI35_RS14865	COG0531	amino acid
VI35_RS14870	COG0531	amino acid
VI35_RS14880	COG1283	sodium-dependent phosphate transmembrane transporter activity
VI35_RS14890	COG3384	dioxygenase
VI35_RS14895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VI35_RS14895	COG2205	protein histidine kinase activity
VI35_RS14930	COG1388	LysM domain
VI35_RS14930	COG1376	ErfK ybiS ycfS ynhG family protein
VI35_RS14945	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
VI35_RS14950	COG0791	NLP P60 protein
VI35_RS14960	COG3118	belongs to the thioredoxin family
VI35_RS14970	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VI35_RS14975	COG0788	formyltetrahydrofolate deformylase activity
VI35_RS15000	COG1196	nuclear chromosome segregation
VI35_RS15000	COG0739	heme binding
VI35_RS15000	COG0741	lytic transglycosylase activity
VI35_RS15005	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VI35_RS15010	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VI35_RS15015	COG0673	inositol 2-dehydrogenase activity
VI35_RS15060	COG1032	radical SAM domain protein
VI35_RS15065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VI35_RS15115	COG0281	malic enzyme
VI35_RS15120	COG2207	Transcriptional regulator
VI35_RS15145	COG0095	Lipoate-protein ligase
VI35_RS15155	COG0019	diaminopimelate decarboxylase activity
VI35_RS15165	COG0678	peroxiredoxin activity
VI35_RS15170	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
VI35_RS15180	COG1126	abc transporter atp-binding protein
VI35_RS15190	COG4597	amino acid ABC transporter
VI35_RS15215	COG0545	Peptidyl-prolyl cis-trans isomerase
VI35_RS15250	COG1940	carbohydrate kinase activity
VI35_RS15275	COG0745	RESPONSE REGULATOR receiver
VI35_RS15280	COG0346	lactoylglutathione lyase activity
VI35_RS15290	COG3284	Transcriptional regulator
VI35_RS15315	COG0667	Aldo Keto reductase
VI35_RS15340	COG1566	PFAM secretion protein HlyD family protein
VI35_RS15365	COG0602	queuosine metabolic process
VI35_RS15370	COG1328	CTP reductase activity
VI35_RS15380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VI35_RS15385	COG3115	cell septum assembly
VI35_RS15410	COG3108	Peptidase M15
VI35_RS15415	COG2989	Protein conserved in bacteria
VI35_RS15430	COG0463	Glycosyl transferase, family 2
VI35_RS15445	COG0366	Alpha amylase catalytic
VI35_RS15480	COG3706	GGDEF domain
VI35_RS15485	COG0037	tRNA processing
VI35_RS15500	COG0488	(ABC) transporter
VI35_RS15510	COG0531	amino acid
VI35_RS15515	COG0814	amino acid
VI35_RS15530	COG0825	malonyl-CoA metabolic process
VI35_RS15550	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VI35_RS15555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VI35_RS15560	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VI35_RS15575	COG0750	zinc metalloprotease
VI35_RS15585	COG0575	Belongs to the CDS family
VI35_RS15595	COG0233	cytoplasmic translational termination
VI35_RS15600	COG0528	UMP kinase activity
VI35_RS15605	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VI35_RS15610	COG0052	Belongs to the universal ribosomal protein uS2 family
VI35_RS15615	COG0024	Methionine aminopeptidase
VI35_RS15620	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VI35_RS15625	COG2171	N-acyltransferase activity
VI35_RS15635	COG1263	PTS System
VI35_RS15635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VI35_RS15645	COG4580	involved in the transport of maltose and maltodextrins
VI35_RS15655	COG0564	pseudouridine synthase activity
VI35_RS15660	COG3098	single-species biofilm formation
VI35_RS15685	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VI35_RS15695	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VI35_RS15695	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VI35_RS15710	COG1611	Belongs to the LOG family
VI35_RS15720	COG0473	3-isopropylmalate dehydrogenase activity
VI35_RS15730	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VI35_RS15735	COG2363	Small membrane protein
VI35_RS15745	COG0583	DNA-binding transcription factor activity
VI35_RS15750	COG0840	transmembrane signaling receptor activity
VI35_RS15755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VI35_RS15770	COG1477	protein flavinylation
VI35_RS15775	COG2871	sodium ion transport
VI35_RS15780	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VI35_RS15785	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VI35_RS15790	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VI35_RS15795	COG1805	sodium ion transport
VI35_RS15800	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VI35_RS15805	COG0271	Belongs to the BolA IbaG family
VI35_RS15810	COG2813	Specifically methylates the guanine in position
VI35_RS15820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VI35_RS15830	COG2211	Major facilitator Superfamily
VI35_RS15840	COG1666	GTP binding
VI35_RS15845	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VI35_RS15895	COG4104	PAAR repeat-containing protein
VI35_RS15915	COG2771	luxR family
VI35_RS15920	COG0659	secondary active sulfate transmembrane transporter activity
VI35_RS15935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VI35_RS15945	COG1151	hydroxylamine reductase activity
VI35_RS15950	COG0783	Belongs to the Dps family
VI35_RS15990	COG4221	oxidoreductase activity
VI35_RS16000	COG0415	Belongs to the DNA photolyase family
VI35_RS16005	COG0789	Transcriptional regulator
VI35_RS16010	COG3272	Protein of unknown function (DUF1722)
VI35_RS16035	COG1605	Chorismate mutase
VI35_RS16035	COG0077	Prephenate dehydratase
VI35_RS16060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VI35_RS16075	COG0457	Tetratricopeptide repeat
VI35_RS16090	COG2133	pyrroloquinoline quinone binding
VI35_RS16100	COG1349	DNA-binding transcription factor activity
VI35_RS16105	COG2084	Dehydrogenase
VI35_RS16115	COG0235	Class ii aldolase
VI35_RS16120	COG3622	Belongs to the hyi family
VI35_RS16125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VI35_RS16130	COG2610	gluconate transmembrane transporter activity
VI35_RS16150	COG0300	oxidoreductase activity
VI35_RS16195	COG3813	Protein conserved in bacteria
VI35_RS16210	COG1280	lysine exporter protein (LysE YggA)
VI35_RS16220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VI35_RS16290	COG1566	PFAM secretion protein HlyD family protein
VI35_RS16300	COG0114	fumarate hydratase activity
VI35_RS16310	COG0506	proline dehydrogenase activity
VI35_RS16310	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
VI35_RS16310	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
VI35_RS16315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VI35_RS16330	COG0737	Belongs to the 5'-nucleotidase family
VI35_RS16355	COG0545	Peptidyl-prolyl cis-trans isomerase
VI35_RS16365	COG2900	Belongs to the SlyX family
VI35_RS16370	COG1047	Peptidyl-prolyl cis-trans
VI35_RS16375	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
VI35_RS16385	COG0835	chemotaxis
VI35_RS16385	COG0784	Response regulator, receiver
VI35_RS16395	COG3706	GGDEF domain
VI35_RS16395	COG5001	Diguanylate cyclase
VI35_RS16395	COG2203	Gaf domain
VI35_RS16395	COG4251	negative regulation of phosphorylation
VI35_RS16400	COG3089	Belongs to the UPF0270 family
VI35_RS16405	COG3954	Phosphoribulokinase
VI35_RS16420	COG1765	OsmC-like protein
VI35_RS16430	COG2226	methyltransferase
VI35_RS16445	COG2814	Major facilitator Superfamily
VI35_RS16470	COG0748	coenzyme F420 binding
VI35_RS16475	COG3721	Heme iron utilization protein
VI35_RS16485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VI35_RS16510	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VI35_RS16520	COG0463	Glycosyl transferase, family 2
VI35_RS16525	COG0741	lytic transglycosylase activity
VI35_RS16530	COG0488	(ABC) transporter
VI35_RS16545	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VI35_RS16555	COG3178	'Phosphotransferase
VI35_RS16560	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VI35_RS16570	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VI35_RS16575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VI35_RS16585	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VI35_RS16605	COG3314	Sporulation integral membrane protein YlbJ
VI35_RS16610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VI35_RS16615	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VI35_RS16620	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VI35_RS16625	COG0142	geranyltranstransferase activity
VI35_RS16630	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VI35_RS16635	COG0330	HflC and HflK could
VI35_RS16640	COG0330	HflC and HflK could
VI35_RS16645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VI35_RS16650	COG1923	regulation of RNA biosynthetic process
VI35_RS16655	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VI35_RS16660	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VI35_RS16670	COG0802	atpase or kinase
VI35_RS16695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VI35_RS16700	COG2011	ABC-type metal ion transport system permease component
VI35_RS16705	COG1464	Belongs to the NlpA lipoprotein family
VI35_RS16740	COG0784	Response regulator, receiver
VI35_RS16740	COG2198	Histidine kinase
VI35_RS16740	COG5002	protein histidine kinase activity
VI35_RS16775	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VI35_RS16780	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VI35_RS16785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VI35_RS16790	COG2716	regulation of RNA biosynthetic process
VI35_RS16795	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VI35_RS16800	COG3013	Belongs to the UPF0304 family
VI35_RS16810	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VI35_RS16815	COG0280	phosphate acetyltransferase
VI35_RS16815	COG0857	belongs to the CobB CobQ family
VI35_RS16820	COG0440	acetolactate synthase activity
VI35_RS16830	COG0028	Belongs to the TPP enzyme family
VI35_RS16840	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VI35_RS16845	COG0671	phosphoesterase, PA-phosphatase related
VI35_RS16855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VI35_RS16860	COG0473	3-isopropylmalate dehydrogenase activity
VI35_RS16870	COG0066	3-isopropylmalate dehydratase activity
VI35_RS16895	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VI35_RS16910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VI35_RS16980	COG0577	efflux transmembrane transporter activity
VI35_RS16980	COG1136	(ABC) transporter
VI35_RS16990	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
VI35_RS17025	COG2203	Gaf domain
VI35_RS17025	COG2199	diguanylate cyclase activity
VI35_RS17030	COG0513	Belongs to the DEAD box helicase family
VI35_RS17040	COG2207	Transcriptional regulator
VI35_RS17040	COG1917	Cupin 2, conserved barrel domain protein
VI35_RS17075	COG0154	amidase activity
VI35_RS17090	COG2852	Protein conserved in bacteria
VI35_RS17100	COG1902	pentaerythritol trinitrate reductase activity
VI35_RS17110	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VI35_RS17115	COG0456	acetyltransferase
VI35_RS17135	COG5001	Diguanylate cyclase
VI35_RS17135	COG5002	protein histidine kinase activity
VI35_RS17155	COG0456	acetyltransferase
VI35_RS17165	COG1022	Amp-dependent synthetase and ligase
VI35_RS17175	COG1794	racemase activity, acting on amino acids and derivatives
VI35_RS17190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VI35_RS17210	COG0733	neurotransmitter:sodium symporter activity
VI35_RS17225	COG0561	phosphatase activity
VI35_RS17295	COG1640	4-alpha-glucanotransferase
VI35_RS17300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VI35_RS17310	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VI35_RS17315	COG0840	transmembrane signaling receptor activity
VI35_RS17390	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VI35_RS17395	COG2885	chlorophyll binding
VI35_RS17400	COG0823	Involved in the tonB-independent uptake of proteins
VI35_RS17415	COG0811	peptide transport
VI35_RS17420	COG0824	Thioesterase
VI35_RS17425	COG3790	cyd operon protein YbgE
VI35_RS17430	COG4890	Cyd operon protein YbgT
VI35_RS17435	COG1294	oxidase, subunit
VI35_RS17440	COG1271	oxidase subunit
VI35_RS17460	COG0632	four-way junction helicase activity
VI35_RS17470	COG0442	prolyl-tRNA aminoacylation
VI35_RS17475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VI35_RS17480	COG4221	oxidoreductase activity
VI35_RS17495	COG1024	Enoyl-CoA hydratase
VI35_RS17515	COG4166	transmembrane transport
VI35_RS17525	COG0840	transmembrane signaling receptor activity
VI35_RS17530	COG0513	Belongs to the DEAD box helicase family
VI35_RS17565	COG3118	belongs to the thioredoxin family
VI35_RS17565	COG0457	Tetratricopeptide repeat
VI35_RS17575	COG1215	transferase activity, transferring glycosyl groups
VI35_RS17595	COG2194	sulfuric ester hydrolase activity
VI35_RS17615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VI35_RS17620	COG1328	CTP reductase activity
VI35_RS17650	COG3397	chitin binding
VI35_RS17660	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VI35_RS17665	COG4208	sulfate ABC transporter
VI35_RS17680	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
VI35_RS17710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VI35_RS17715	COG0564	pseudouridine synthase activity
VI35_RS17735	COG0459	protein refolding
VI35_RS17740	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VI35_RS17750	COG3030	protein affecting phage T7 exclusion by the F plasmid
VI35_RS17755	COG1027	Aspartate ammonia-lyase
VI35_RS17765	COG2918	glutathione biosynthetic process
VI35_RS17775	COG1238	metal cluster binding
VI35_RS17815	COG0359	binds to the 23S rRNA
VI35_RS17820	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VI35_RS17825	COG0360	Binds together with S18 to 16S ribosomal RNA
VI35_RS17830	COG1914	H( )-stimulated, divalent metal cation uptake system
VI35_RS17840	COG2153	protein acetylation
VI35_RS17855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VI35_RS17860	COG0557	exoribonuclease II activity
VI35_RS17865	COG3706	GGDEF domain
VI35_RS17870	COG1854	S-ribosylhomocysteine lyase activity
VI35_RS17925	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VI35_RS17930	COG1047	Peptidyl-prolyl cis-trans
VI35_RS17935	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VI35_RS17940	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VI35_RS17945	COG0196	riboflavin kinase activity
VI35_RS17955	COG0268	Binds directly to 16S ribosomal RNA
VI35_RS17960	COG0640	Transcriptional regulator
VI35_RS17965	COG0583	DNA-binding transcription factor activity
VI35_RS17975	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VI35_RS17980	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VI35_RS17985	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VI35_RS18010	COG0335	large ribosomal subunit rRNA binding
VI35_RS18015	COG0336	Belongs to the RNA methyltransferase TrmD family
VI35_RS18020	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VI35_RS18025	COG0228	four-way junction DNA binding
VI35_RS18030	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VI35_RS18035	COG4137	Cytochrome C assembly protein
VI35_RS18040	COG4536	flavin adenine dinucleotide binding
VI35_RS18050	COG1017	nitric oxide dioxygenase activity
VI35_RS18050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VI35_RS18055	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VI35_RS18060	COG0039	L-malate dehydrogenase activity
VI35_RS18065	COG4160	amino acid transport
VI35_RS18070	COG4215	(ABC) transporter
VI35_RS18075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VI35_RS18080	COG1126	abc transporter atp-binding protein
VI35_RS18085	COG1438	arginine binding
VI35_RS18090	COG2837	iron assimilation
VI35_RS18095	COG3842	ATPase activity
VI35_RS18110	COG0347	Belongs to the P(II) protein family
VI35_RS18130	COG0583	DNA-binding transcription factor activity
VI35_RS18145	COG1929	Belongs to the glycerate kinase type-1 family
VI35_RS18150	COG2610	gluconate transmembrane transporter activity
VI35_RS18155	COG3835	regulator
VI35_RS18160	COG3112	Uncharacterised protein family (UPF0231)
VI35_RS18180	COG1872	DUF167
VI35_RS18185	COG0762	integral membrane protein
VI35_RS18190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VI35_RS18195	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VI35_RS18210	COG3022	response to hydroperoxide
VI35_RS18215	COG0513	Belongs to the DEAD box helicase family
VI35_RS18220	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VI35_RS18240	COG0735	belongs to the Fur family
VI35_RS18320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VI35_RS18335	COG0776	regulation of translation
VI35_RS18340	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VI35_RS18350	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VI35_RS18365	COG0560	Phosphoserine phosphatase
VI35_RS18375	COG5002	protein histidine kinase activity
VI35_RS18375	COG3447	MASE1 domain protein
VI35_RS18375	COG5001	Diguanylate cyclase
VI35_RS18380	COG0813	purine-nucleoside phosphorylase activity
VI35_RS18385	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VI35_RS18390	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VI35_RS18395	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VI35_RS18405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VI35_RS18415	COG2165	general secretion pathway protein
VI35_RS18425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VI35_RS18430	COG0004	ammonium transporteR
VI35_RS18455	COG0795	lipopolysaccharide-transporting ATPase activity
VI35_RS18460	COG0795	lipopolysaccharide-transporting ATPase activity
VI35_RS18465	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VI35_RS18470	COG2927	DNA polymerase III (CHI subunit)
VI35_RS18475	COG0525	valine-tRNA ligase activity
VI35_RS18480	COG1253	flavin adenine dinucleotide binding
VI35_RS18485	COG0586	Pfam SNARE associated Golgi protein
VI35_RS18490	COG1686	Belongs to the peptidase S11 family
VI35_RS18525	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VI35_RS18530	COG0527	aspartate kinase activity
VI35_RS18535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VI35_RS18545	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VI35_RS18550	COG1546	Belongs to the CinA family
VI35_RS18560	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VI35_RS18580	COG3068	Protein conserved in bacteria
VI35_RS18590	COG0739	heme binding
VI35_RS18610	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VI35_RS18615	COG1121	(ABC) transporter
VI35_RS18620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VI35_RS18635	COG1573	uracil-dna glycosylase
VI35_RS18640	COG2962	Rard protein
VI35_RS18645	COG2827	Endonuclease containing a URI domain
VI35_RS18660	COG1842	Phage shock protein A
VI35_RS18665	COG0204	Acyl-transferase
VI35_RS18690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VI35_RS18740	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VI35_RS18760	COG1289	transmembrane transporter activity
VI35_RS18765	COG1566	PFAM secretion protein HlyD family protein
VI35_RS18780	COG1051	belongs to the nudix hydrolase family
VI35_RS18785	COG3150	esterase
VI35_RS18795	COG3151	Protein conserved in bacteria
VI35_RS18800	COG0494	nUDIX hydrolase
VI35_RS18805	COG1538	Outer membrane efflux protein
VI35_RS18810	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VI35_RS18810	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VI35_RS18815	COG1560	Kdo2-lipid A biosynthetic process
VI35_RS18830	COG2771	luxR family
VI35_RS18835	COG3916	Acyl-homoserine-lactone synthase
VI35_RS18845	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VI35_RS18850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VI35_RS18850	COG2213	PTS system mannitol-specific
VI35_RS18855	COG0246	Mannitol dehydrogenase
VI35_RS18860	COG3722	fumarate hydratase activity
VI35_RS18900	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VI35_RS18905	COG0513	Belongs to the DEAD box helicase family
VI35_RS18925	COG1575	Belongs to the MenA family. Type 1 subfamily
VI35_RS18940	COG0596	Alpha beta hydrolase
VI35_RS18945	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VI35_RS18960	COG3291	Pkd domain containing protein
VI35_RS18965	COG2949	membrane
VI35_RS18970	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
VI35_RS18980	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VI35_RS19020	COG1979	alcohol dehydrogenase
VI35_RS19035	COG4221	oxidoreductase activity
VI35_RS19055	COG1285	pathogenesis
VI35_RS19070	COG1368	sulfuric ester hydrolase activity
VI35_RS19075	COG1522	sequence-specific DNA binding
VI35_RS19085	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VI35_RS19095	COG1058	Belongs to the CinA family
VI35_RS19095	COG1546	Belongs to the CinA family
VI35_RS19100	COG1988	membrane-bound metal-dependent
VI35_RS19110	COG0561	phosphatase activity
VI35_RS19115	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
VI35_RS19140	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VI35_RS19145	COG0019	diaminopimelate decarboxylase activity
VI35_RS19155	COG1965	Belongs to the frataxin family
VI35_RS19160	COG0400	carboxylic ester hydrolase activity
VI35_RS19165	COG3072	Adenylate cyclase
VI35_RS19170	COG0181	hydroxymethylbilane synthase activity
VI35_RS19180	COG2959	enzyme of heme biosynthesis
VI35_RS19185	COG3071	HemY protein
VI35_RS19195	COG1494	fructose-1,6-bisphosphatase
VI35_RS19225	COG1733	regulation of RNA biosynthetic process
VI35_RS19245	COG3932	Exopolysaccharide synthesis, ExoD
VI35_RS19260	COG0110	maltose O-acetyltransferase activity
VI35_RS19300	COG2022	thiamine diphosphate biosynthetic process
VI35_RS19315	COG0352	thiamine-phosphate diphosphorylase activity
VI35_RS19320	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VI35_RS19335	COG0745	RESPONSE REGULATOR receiver
VI35_RS19345	COG0189	ligase activity
VI35_RS19380	COG2321	neutral zinc metallopeptidase
VI35_RS19395	COG1366	Belongs to the anti-sigma-factor antagonist family
VI35_RS19400	COG2172	sigma factor antagonist activity
VI35_RS19410	COG3437	response regulator, receiver
VI35_RS19440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VI35_RS19455	COG0424	maF-like protein
VI35_RS19460	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VI35_RS19465	COG1792	Involved in formation and maintenance of cell shape
VI35_RS19470	COG1077	Cell shape determining protein MreB Mrl
VI35_RS19515	COG1459	type II secretion system
VI35_RS19575	COG2200	EAL domain
VI35_RS19580	COG0387	Pfam Sodium calcium exchanger
VI35_RS19585	COG2986	histidine ammonia-lyase
VI35_RS19590	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VI35_RS19595	COG0010	Belongs to the arginase family
VI35_RS19600	COG1228	amidohydrolase
VI35_RS19605	COG2188	Transcriptional regulator
VI35_RS19610	COG0288	reversible hydration of carbon dioxide
VI35_RS19620	COG2177	Part of the ABC transporter FtsEX involved in
VI35_RS19625	COG2884	Cell division ATP-binding protein ftsE
VI35_RS19630	COG0552	protein localization to endoplasmic reticulum
VI35_RS19660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VI35_RS19665	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VI35_RS19675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VI35_RS19685	COG2095	MarC family integral membrane protein
VI35_RS19695	COG1301	dicarboxylic acid transport
VI35_RS19705	COG0583	DNA-binding transcription factor activity
VI35_RS19720	COG3714	YhhN family
VI35_RS19735	COG2358	TRAP transporter, solute receptor (TAXI family
VI35_RS19740	COG1770	oligopeptidase
VI35_RS19755	COG4221	oxidoreductase activity
VI35_RS19760	COG0583	DNA-binding transcription factor activity
VI35_RS19820	COG0203	ribosomal protein L17
VI35_RS19825	COG0202	RNA polymerase activity
VI35_RS19830	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VI35_RS19835	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VI35_RS19840	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VI35_RS19845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VI35_RS19850	COG0201	protein transport
VI35_RS19855	COG0200	Binds to the 23S rRNA
VI35_RS19860	COG1841	ribosomal large subunit assembly
VI35_RS19865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VI35_RS19870	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VI35_RS19875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VI35_RS19880	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VI35_RS19885	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VI35_RS19890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VI35_RS19895	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VI35_RS19900	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VI35_RS19905	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VI35_RS19910	COG0255	Belongs to the universal ribosomal protein uL29 family
VI35_RS19915	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VI35_RS19920	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VI35_RS19925	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VI35_RS19930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VI35_RS19935	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VI35_RS19940	COG0089	rRNA binding
VI35_RS19945	COG0088	Forms part of the polypeptide exit tunnel
VI35_RS19950	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VI35_RS19955	COG0051	transcription antitermination factor activity, RNA binding
VI35_RS19965	COG2205	protein histidine kinase activity
VI35_RS19975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VI35_RS19980	COG2183	response to ionizing radiation
VI35_RS19995	COG0596	Alpha beta hydrolase
VI35_RS20000	COG1040	competence protein
VI35_RS20005	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VI35_RS20005	COG0316	Belongs to the HesB IscA family
VI35_RS20010	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VI35_RS20015	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VI35_RS20020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VI35_RS20025	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VI35_RS20030	COG4942	peptidase
VI35_RS20055	COG0800	Aldolase
VI35_RS20060	COG0129	dihydroxy-acid dehydratase activity
VI35_RS20065	COG3265	gluconokinase activity
VI35_RS20070	COG2610	gluconate transmembrane transporter activity
VI35_RS20090	COG0456	acetyltransferase
VI35_RS20100	COG1490	D-aminoacyl-tRNA deacylase activity
VI35_RS20105	COG1295	ribonuclease BN
VI35_RS20110	COG1217	gtp-binding protein TYPA
VI35_RS20115	COG0174	glutamine synthetase
VI35_RS20125	COG3852	Histidine kinase
VI35_RS20135	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VI35_RS20140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VI35_RS20150	COG3078	GTPase activator activity
VI35_RS20160	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VI35_RS20170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VI35_RS20180	COG0009	L-threonylcarbamoyladenylate synthase
VI35_RS20185	COG0551	DNA topoisomerase type I activity
VI35_RS20190	COG2922	Belongs to the Smg family
VI35_RS20205	COG0242	peptide deformylase activity
VI35_RS20210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VI35_RS20215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VI35_RS20215	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VI35_RS20220	COG0569	domain protein
VI35_RS20230	COG1322	Protein conserved in bacteria
VI35_RS20260	COG0519	Catalyzes the synthesis of GMP from XMP
VI35_RS20260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VI35_RS20270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VI35_RS20275	COG1396	sequence-specific DNA binding
VI35_RS20280	COG1012	belongs to the aldehyde dehydrogenase family
VI35_RS20285	COG2962	Rard protein
VI35_RS20335	COG0583	DNA-binding transcription factor activity
VI35_RS20365	COG0210	DNA helicase
VI35_RS20370	COG1744	ABC transporter substrate-binding protein PnrA-like
VI35_RS20375	COG3845	ABC transporter
VI35_RS20380	COG4603	Belongs to the binding-protein-dependent transport system permease family
VI35_RS20385	COG1079	Belongs to the binding-protein-dependent transport system permease family
VI35_RS20390	COG0583	DNA-binding transcription factor activity
VI35_RS20415	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VI35_RS20420	COG0385	Bile acid
VI35_RS20425	COG0531	amino acid
VI35_RS20430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VI35_RS20435	COG0531	amino acid
VI35_RS20440	COG2731	YhcH YjgK YiaL family protein
VI35_RS20445	COG3250	beta-galactosidase activity
VI35_RS20450	COG1609	Transcriptional regulator
VI35_RS20490	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VI35_RS20495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VI35_RS20495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VI35_RS20500	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VI35_RS20505	COG3074	FtsZ-dependent cytokinesis
VI35_RS20525	COG0745	RESPONSE REGULATOR receiver
VI35_RS20530	COG2205	protein histidine kinase activity
VI35_RS20535	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VI35_RS20540	COG0534	Mate efflux family protein
VI35_RS20555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VI35_RS20560	COG2937	Belongs to the GPAT DAPAT family
VI35_RS20565	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VI35_RS20570	COG3161	chorismate lyase activity
VI35_RS20575	COG1580	Controls the rotational direction of flagella during chemotaxis
VI35_RS20645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VI35_RS20655	COG0156	8-amino-7-oxononanoate synthase activity
VI35_RS20660	COG1063	alcohol dehydrogenase
VI35_RS20685	COG2166	iron-sulfur cluster assembly
VI35_RS20690	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VI35_RS20720	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
VI35_RS20735	COG0006	proline dipeptidase activity
VI35_RS20740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VI35_RS20750	COG0183	Belongs to the thiolase family
VI35_RS20795	COG0425	Belongs to the sulfur carrier protein TusA family
VI35_RS20800	COG0251	oxidation-reduction process
VI35_RS20815	COG2885	chlorophyll binding
VI35_RS20825	COG1335	isochorismatase
VI35_RS20830	COG2818	Glycosylase
VI35_RS20835	COG0752	glycyl-tRNA synthetase alpha subunit
VI35_RS20840	COG0751	glycine-tRNA ligase activity
VI35_RS20850	COG5001	Diguanylate cyclase
VI35_RS20850	COG2203	Gaf domain
VI35_RS20850	COG3706	GGDEF domain
VI35_RS20850	COG4251	negative regulation of phosphorylation
VI35_RS20870	COG0814	amino acid
VI35_RS20875	COG3033	Beta-eliminating lyase
VI35_RS20885	COG0348	domain, Protein
VI35_RS20895	COG0446	pyridine nucleotide-disulphide oxidoreductase
VI35_RS20900	COG1773	rubredoxin
VI35_RS20900	COG0426	domain, Protein
VI35_RS20905	COG3604	Transcriptional regulator
VI35_RS20910	COG1609	Transcriptional regulator
VI35_RS20950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VI35_RS20980	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VI35_RS20995	COG3118	belongs to the thioredoxin family
VI35_RS21005	COG0248	Ppx GppA phosphatase
VI35_RS21015	COG0742	ribosomal rna small subunit methyltransferase
VI35_RS21035	COG0084	hydrolase, TatD family'
VI35_RS21040	COG0805	protein transport
VI35_RS21045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VI35_RS21050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VI35_RS21055	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VI35_RS21060	COG3165	ubiquinone biosynthetic process from chorismate
VI35_RS21075	COG0402	S-adenosylhomocysteine deaminase activity
VI35_RS21110	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VI35_RS21115	COG0848	biopolymer transport protein
VI35_RS21120	COG0811	peptide transport
VI35_RS21125	COG0811	peptide transport
VI35_RS21135	COG2771	luxR family
VI35_RS21140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VI35_RS21145	COG1349	DNA-binding transcription factor activity
VI35_RS21150	COG0745	RESPONSE REGULATOR receiver
VI35_RS21155	COG2205	protein histidine kinase activity
VI35_RS21165	COG4452	Inner membrane protein CreD
VI35_RS21170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VI35_RS21175	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VI35_RS21180	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VI35_RS21185	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VI35_RS21190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VI35_RS21195	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VI35_RS21200	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VI35_RS21210	COG0356	it plays a direct role in the translocation of protons across the membrane
VI35_RS21220	COG1475	DNA binding
VI35_RS21225	COG1192	Involved in chromosome partitioning
VI35_RS21230	COG0357	Ribosomal RNA small subunit methyltransferase G
VI35_RS21235	COG0445	tRNA wobble uridine modification
VI35_RS21245	COG4774	siderophore transport
VI35_RS21250	COG4615	Cyclic peptide transporter
VI35_RS21255	COG1120	ATPase activity
VI35_RS21260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VI35_RS21270	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VI35_RS21275	COG0706	membrane insertase activity
VI35_RS21280	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
VI35_RS21285	COG0594	ribonuclease P activity
VI35_RS21290	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VI35_RS21295	COG1126	abc transporter atp-binding protein