locus-tag	class	description
MC60_RS00005	COG2373	Large extracellular alpha-helical protein
MC60_RS00010	COG4953	penicillin-binding protein 1C
MC60_RS00020	COG0301	tRNA thio-modification
MC60_RS00020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC60_RS00080	COG2089	acid synthase
MC60_RS00090	COG1083	cytidylyl-transferase
MC60_RS00105	COG1028	Short-chain dehydrogenase reductase Sdr
MC60_RS00110	COG0318	PFAM AMP-dependent synthetase and ligase
MC60_RS00125	COG1215	transferase activity, transferring glycosyl groups
MC60_RS00140	COG1216	Glycosyl transferase, family 2
MC60_RS00160	COG2226	methyltransferase
MC60_RS00165	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MC60_RS00170	COG1086	Polysaccharide biosynthesis protein
MC60_RS00175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MC60_RS00185	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MC60_RS00205	COG0346	lactoylglutathione lyase activity
MC60_RS00210	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MC60_RS00215	COG4660	Part of a membrane complex involved in electron transport
MC60_RS00220	COG4659	FMN binding
MC60_RS00225	COG4658	electron transport chain
MC60_RS00235	COG2878	Part of a membrane complex involved in electron transport
MC60_RS00240	COG4657	Part of a membrane complex involved in electron transport
MC60_RS00245	COG0697	spore germination
MC60_RS00265	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MC60_RS00270	COG1288	antiporter activity
MC60_RS00275	COG0436	Aminotransferase
MC60_RS00285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MC60_RS00290	COG2027	D-alanyl-D-alanine carboxypeptidase
MC60_RS00295	COG1061	Type III restriction enzyme res subunit
MC60_RS00300	COG1566	PFAM secretion protein HlyD family protein
MC60_RS00310	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MC60_RS00310	COG3264	Mechanosensitive ion channel
MC60_RS00315	COG1966	Carbon starvation protein
MC60_RS00320	COG3279	Response regulator of the LytR AlgR family
MC60_RS00325	COG3275	phosphorelay sensor kinase activity
MC60_RS00335	COG1012	belongs to the aldehyde dehydrogenase family
MC60_RS00335	COG1454	alcohol dehydrogenase
MC60_RS00340	COG2095	MarC family integral membrane protein
MC60_RS00350	COG0601	transmembrane transport
MC60_RS00355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MC60_RS00370	COG0861	Integral membrane protein TerC family
MC60_RS00375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MC60_RS00385	COG1301	dicarboxylic acid transport
MC60_RS00405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MC60_RS00420	COG0537	adenosine 5'-monophosphoramidase activity
MC60_RS00455	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MC60_RS00460	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MC60_RS00475	COG2354	Protein conserved in bacteria
MC60_RS00485	COG1164	Oligoendopeptidase f
MC60_RS00490	COG3150	esterase
MC60_RS00495	COG1252	NADH dehydrogenase
MC60_RS00505	COG0393	Putative heavy-metal-binding
MC60_RS00510	COG1368	sulfuric ester hydrolase activity
MC60_RS00520	COG0527	aspartate kinase activity
MC60_RS00525	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MC60_RS00525	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MC60_RS00530	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MC60_RS00555	COG0583	DNA-binding transcription factor activity
MC60_RS00560	COG1620	l-lactate permease
MC60_RS00565	COG0247	lactate metabolic process
MC60_RS00570	COG1139	Iron-sulfur cluster binding protein
MC60_RS00595	COG3039	Transposase
MC60_RS00610	COG0577	efflux transmembrane transporter activity
MC60_RS00615	COG1136	(ABC) transporter
MC60_RS00635	COG2814	Major facilitator Superfamily
MC60_RS00660	COG0672	)-iron permease
MC60_RS00695	COG2308	Evidence 4 Homologs of previously reported genes of
MC60_RS00715	COG0659	secondary active sulfate transmembrane transporter activity
MC60_RS00740	COG3501	Rhs element vgr protein
MC60_RS00750	COG3209	COG3209 Rhs family protein
MC60_RS00755	COG3415	Transposase
MC60_RS00755	COG2801	Transposase and inactivated derivatives
MC60_RS00815	COG3829	transcription factor binding
MC60_RS00855	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
MC60_RS00860	COG0437	4 iron, 4 sulfur cluster binding
MC60_RS00865	COG5557	Pfam Polysulphide reductase, NrfD
MC60_RS00870	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
MC60_RS00875	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MC60_RS00880	COG1773	rubredoxin
MC60_RS00895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MC60_RS00905	COG1124	(ABC) transporter
MC60_RS00910	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MC60_RS00915	COG0375	protein maturation
MC60_RS00920	COG0309	Hydrogenase expression formation protein (HypE)
MC60_RS00930	COG0298	carbon dioxide binding
MC60_RS00935	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
MC60_RS00940	COG3158	transport of potassium into the cell
MC60_RS00945	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MC60_RS00950	COG0326	Molecular chaperone. Has ATPase activity
MC60_RS00955	COG0563	adenylate kinase activity
MC60_RS00960	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MC60_RS00965	COG3788	relative of glutathione S-transferase, MAPEG superfamily
MC60_RS00970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MC60_RS00975	COG0840	transmembrane signaling receptor activity
MC60_RS00990	COG5001	Diguanylate cyclase
MC60_RS00990	COG3300	MHYT domain
MC60_RS01015	COG1021	2,3-dihydroxybenzoate-AMP ligase
MC60_RS01020	COG1535	isochorismatase
MC60_RS01020	COG3433	isochorismatase activity
MC60_RS01025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MC60_RS01030	COG1028	Short-chain dehydrogenase reductase Sdr
MC60_RS01040	COG0300	oxidoreductase activity
MC60_RS01040	COG3321	synthase
MC60_RS01040	COG1028	Short-chain dehydrogenase reductase Sdr
MC60_RS01040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MC60_RS01040	COG0318	PFAM AMP-dependent synthetase and ligase
MC60_RS01055	COG1120	ATPase activity
MC60_RS01060	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC60_RS01065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC60_RS01070	COG4771	TonB-dependent receptor
MC60_RS01110	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MC60_RS01115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MC60_RS01120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MC60_RS01125	COG0861	Integral membrane protein TerC family
MC60_RS01140	COG1022	Amp-dependent synthetase and ligase
MC60_RS01145	COG0295	cytidine deaminase activity
MC60_RS01150	COG1346	cytolysis
MC60_RS01155	COG1380	Effector of murein hydrolase LrgA
MC60_RS01160	COG3345	alpha-galactosidase
MC60_RS01170	COG2925	Exonuclease
MC60_RS01205	COG0300	oxidoreductase activity
MC60_RS01230	COG1085	galactose-1-phosphate uridylyltransferase
MC60_RS01235	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MC60_RS01240	COG1609	Transcriptional regulator
MC60_RS01245	COG4580	involved in the transport of maltose and maltodextrins
MC60_RS01270	COG2182	Extracellular solute-binding protein
MC60_RS01275	COG1175	transmembrane transport
MC60_RS01280	COG3833	ABC-type maltose transport systems, permease component
MC60_RS01285	COG3867	Arabinogalactan endo-beta-1,4-galactanase
MC60_RS01290	COG1874	Beta-galactosidase
MC60_RS01295	COG1263	PTS System
MC60_RS01295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC60_RS01370	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MC60_RS01370	COG0392	lysyltransferase activity
MC60_RS01385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MC60_RS01390	COG0436	Aminotransferase
MC60_RS01395	COG0583	DNA-binding transcription factor activity
MC60_RS01400	COG2160	L-arabinose isomerase activity
MC60_RS01410	COG1069	ribulokinase activity
MC60_RS01415	COG1879	ABC-type sugar transport system periplasmic component
MC60_RS01420	COG1129	ABC transporter
MC60_RS01425	COG1172	Belongs to the binding-protein-dependent transport system permease family
MC60_RS01435	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MC60_RS01440	COG0254	rRNA binding
MC60_RS01455	COG1451	nucleotide metabolic process
MC60_RS01470	COG3069	C4-dicarboxylate transmembrane transporter activity
MC60_RS01480	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MC60_RS01480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MC60_RS01485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MC60_RS01505	COG2009	succinate dehydrogenase
MC60_RS01510	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MC60_RS01525	COG0567	Dehydrogenase, E1 component
MC60_RS01530	COG0508	dehydrogenase complex catalyzes the overall conversion of
MC60_RS01535	COG0045	succinate-CoA ligase (ADP-forming) activity
MC60_RS01540	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MC60_RS01555	COG2983	Belongs to the UPF0260 family
MC60_RS01560	COG1882	Formate acetyltransferase
MC60_RS01565	COG2116	formate transmembrane transporter activity
MC60_RS01570	COG1944	ATP diphosphatase activity
MC60_RS01585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MC60_RS01590	COG1278	Cold shock
MC60_RS01595	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MC60_RS01600	COG0542	response to heat
MC60_RS01605	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MC60_RS01610	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MC60_RS01615	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MC60_RS01620	COG3134	Outer membrane lipoprotein
MC60_RS01625	COG3706	GGDEF domain
MC60_RS01630	COG0492	ferredoxin-NADP+ reductase activity
MC60_RS01635	COG0686	Belongs to the AlaDH PNT family
MC60_RS01645	COG0531	amino acid
MC60_RS01645	COG1674	ftsk spoiiie
MC60_RS01650	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MC60_RS01655	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MC60_RS01665	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MC60_RS01670	COG1286	toxin biosynthetic process
MC60_RS01675	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MC60_RS01680	COG2723	6-phospho-beta-galactosidase activity
MC60_RS01685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC60_RS01685	COG1263	PTS System
MC60_RS01690	COG1609	Transcriptional regulator
MC60_RS01700	COG4172	Belongs to the ABC transporter superfamily
MC60_RS01710	COG4171	peptide transport system, permease
MC60_RS01725	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MC60_RS01730	COG1842	Phage shock protein A
MC60_RS01745	COG3106	COG3106 Predicted ATPase
MC60_RS01750	COG3768	UPF0283 membrane protein
MC60_RS01760	COG2154	pterin-4-alpha-carbinolamine dehydratase
MC60_RS01780	COG2885	chlorophyll binding
MC60_RS01790	COG1570	exodeoxyribonuclease VII activity
MC60_RS01815	COG0366	Alpha amylase catalytic
MC60_RS01815	COG1874	Beta-galactosidase
MC60_RS01825	COG0516	GMP reductase activity
MC60_RS01825	COG0517	IMP dehydrogenase activity
MC60_RS01830	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MC60_RS01830	COG0519	Catalyzes the synthesis of GMP from XMP
MC60_RS01860	COG1846	Transcriptional regulator
MC60_RS01870	COG0500	methyltransferase
MC60_RS01880	COG2062	phosphohistidine phosphatase, SixA
MC60_RS01890	COG0697	spore germination
MC60_RS01900	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MC60_RS01905	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MC60_RS01915	COG4591	ABC-type transport system involved in lipoprotein release permease component
MC60_RS01920	COG1136	(ABC) transporter
MC60_RS01925	COG4591	ABC-type transport system involved in lipoprotein release permease component
MC60_RS01930	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
MC60_RS01945	COG0544	peptidyl-prolyl cis-trans isomerase activity
MC60_RS01950	COG0740	serine-type endopeptidase activity
MC60_RS01955	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MC60_RS01960	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MC60_RS01965	COG0776	regulation of translation
MC60_RS01970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MC60_RS01975	COG0488	(ABC) transporter
MC60_RS01980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MC60_RS01985	COG3162	membrane
MC60_RS02000	COG1024	Enoyl-CoA hydratase
MC60_RS02005	COG1115	amino acid carrier protein
MC60_RS02015	COG3228	Belongs to the MtfA family
MC60_RS02020	COG1584	GPR1 FUN34 yaaH family protein
MC60_RS02045	COG1024	Enoyl-CoA hydratase
MC60_RS02050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MC60_RS02055	COG1960	acyl-CoA dehydrogenase activity
MC60_RS02065	COG1960	acyl-CoA dehydrogenase activity
MC60_RS02070	COG1024	Enoyl-CoA hydratase
MC60_RS02075	COG1024	Enoyl-CoA hydratase
MC60_RS02085	COG1028	Short-chain dehydrogenase reductase Sdr
MC60_RS02095	COG0730	response to heat
MC60_RS02115	COG3039	Transposase
MC60_RS02125	COG1172	Belongs to the binding-protein-dependent transport system permease family
MC60_RS02130	COG1172	Belongs to the binding-protein-dependent transport system permease family
MC60_RS02135	COG1129	ABC transporter
MC60_RS02140	COG1879	ABC-type sugar transport system periplasmic component
MC60_RS02145	COG0583	DNA-binding transcription factor activity
MC60_RS02160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MC60_RS02165	COG0243	molybdopterin cofactor binding
MC60_RS02175	COG0583	DNA-binding transcription factor activity
MC60_RS02180	COG2723	6-phospho-beta-galactosidase activity
MC60_RS02190	COG0583	DNA-binding transcription factor activity
MC60_RS02205	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MC60_RS02210	COG0673	inositol 2-dehydrogenase activity
MC60_RS02215	COG0583	DNA-binding transcription factor activity
MC60_RS02225	COG1560	Kdo2-lipid A biosynthetic process
MC60_RS02230	COG1560	Kdo2-lipid A biosynthetic process
MC60_RS02245	COG0417	DNA replication proofreading
MC60_RS02275	COG0534	Mate efflux family protein
MC60_RS02285	COG0307	riboflavin synthase, alpha
MC60_RS02300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MC60_RS02305	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MC60_RS02310	COG0697	spore germination
MC60_RS02315	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MC60_RS02340	COG2996	Protein conserved in bacteria
MC60_RS02360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MC60_RS02365	COG3099	Belongs to the UPF0263 family
MC60_RS02370	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MC60_RS02375	COG2894	cell division
MC60_RS02380	COG0850	regulation of cytokinetic process
MC60_RS02385	COG3100	YcgL domain-containing protein
MC60_RS02390	COG2951	lytic endotransglycosylase activity
MC60_RS02395	COG1760	l-serine dehydratase
MC60_RS02405	COG1760	l-serine dehydratase
MC60_RS02410	COG3123	guanosine phosphorylase activity
MC60_RS02430	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MC60_RS02435	COG2067	long-chain fatty acid transport protein
MC60_RS02440	COG2067	long-chain fatty acid transport protein
MC60_RS02450	COG1595	DNA-templated transcription, initiation
MC60_RS02480	COG0714	Associated with various cellular activities
MC60_RS02485	COG0183	Belongs to the thiolase family
MC60_RS02490	COG1024	Enoyl-CoA hydratase
MC60_RS02490	COG1250	3-hydroxyacyl-CoA dehydrogenase
MC60_RS02500	COG4681	YaeQ
MC60_RS02520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC60_RS02535	COG3134	Outer membrane lipoprotein
MC60_RS02540	COG0318	PFAM AMP-dependent synthetase and ligase
MC60_RS02545	COG2378	regulation of single-species biofilm formation
MC60_RS02555	COG0140	phosphoribosyl-ATP diphosphatase activity
MC60_RS02555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MC60_RS02560	COG0107	imidazoleglycerol-phosphate synthase activity
MC60_RS02565	COG2205	protein histidine kinase activity
MC60_RS02565	COG0784	Response regulator, receiver
MC60_RS02565	COG2198	Histidine kinase
MC60_RS02570	COG2199	diguanylate cyclase activity
MC60_RS02575	COG3437	response regulator, receiver
MC60_RS02580	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MC60_RS02585	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MC60_RS02590	COG0131	Imidazoleglycerol-phosphate dehydratase
MC60_RS02590	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MC60_RS02595	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MC60_RS02600	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MC60_RS02605	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MC60_RS02615	COG1199	ATP-dependent helicase activity
MC60_RS02620	COG1214	PFAM Peptidase M22, glycoprotease
MC60_RS02630	COG0596	Alpha beta hydrolase
MC60_RS02635	COG0318	PFAM AMP-dependent synthetase and ligase
MC60_RS02650	COG0697	spore germination
MC60_RS02660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MC60_RS02665	COG2832	Protein of unknown function (DUF454)
MC60_RS02670	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MC60_RS02680	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MC60_RS02685	COG0583	DNA-binding transcription factor activity
MC60_RS02695	COG3314	Sporulation integral membrane protein YlbJ
MC60_RS02700	COG2197	response regulator
MC60_RS02705	COG0617	tRNA 3'-terminal CCA addition
MC60_RS02705	COG0517	IMP dehydrogenase activity
MC60_RS02705	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MC60_RS02710	COG1643	Atp-dependent helicase
MC60_RS02720	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MC60_RS02730	COG3437	response regulator, receiver
MC60_RS02735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC60_RS02740	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
MC60_RS02745	COG0709	Synthesizes selenophosphate from selenide and ATP
MC60_RS02770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MC60_RS02775	COG0840	transmembrane signaling receptor activity
MC60_RS02780	COG1254	Belongs to the acylphosphatase family
MC60_RS02785	COG0625	glutathione transferase activity
MC60_RS02790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MC60_RS02790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MC60_RS02795	COG0489	protein tyrosine kinase activity
MC60_RS02800	COG0572	uridine kinase
MC60_RS02805	COG0717	Belongs to the dCTP deaminase family
MC60_RS02810	COG0306	phosphate transporter
MC60_RS02815	COG1530	ribonuclease E activity
MC60_RS02820	COG0564	pseudouridine synthase activity
MC60_RS02835	COG1399	metal-binding, possibly nucleic acid-binding protein
MC60_RS02840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MC60_RS02845	COG0416	fatty acid biosynthetic process
MC60_RS02850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MC60_RS02860	COG1028	Short-chain dehydrogenase reductase Sdr
MC60_RS02865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MC60_RS02870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MC60_RS02875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MC60_RS02880	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MC60_RS02885	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MC60_RS02890	COG0470	DNA polymerase III
MC60_RS02895	COG0084	hydrolase, TatD family'
MC60_RS02910	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MC60_RS02910	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MC60_RS02915	COG3008	intermembrane lipid transfer
MC60_RS02920	COG2995	paraquat-inducible protein a
MC60_RS02930	COG3141	response to X-ray
MC60_RS02940	COG1067	ATP-dependent peptidase activity
MC60_RS02945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MC60_RS02960	COG0488	(ABC) transporter
MC60_RS02970	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MC60_RS02970	COG0116	Belongs to the methyltransferase superfamily
MC60_RS02980	COG0167	dihydroorotate dehydrogenase activity
MC60_RS02985	COG2902	Dehydrogenase
MC60_RS02995	COG0308	aminopeptidase N
MC60_RS03005	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
MC60_RS03010	COG1956	GAF domain-containing protein
MC60_RS03020	COG3278	Belongs to the heme-copper respiratory oxidase family
MC60_RS03035	COG2010	Cytochrome c
MC60_RS03045	COG2217	Heavy metal translocating P-type atpase
MC60_RS03060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MC60_RS03065	COG0589	response to stress
MC60_RS03070	COG0037	tRNA processing
MC60_RS03085	COG0625	glutathione transferase activity
MC60_RS03090	COG1869	D-ribose catabolic process
MC60_RS03095	COG1129	ABC transporter
MC60_RS03100	COG1172	Belongs to the binding-protein-dependent transport system permease family
MC60_RS03105	COG1879	ABC-type sugar transport system periplasmic component
MC60_RS03110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MC60_RS03115	COG1609	Transcriptional regulator
MC60_RS03120	COG5001	Diguanylate cyclase
MC60_RS03120	COG3300	MHYT domain
MC60_RS03150	COG0776	regulation of translation
MC60_RS03155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MC60_RS03155	COG0072	phenylalanine-tRNA ligase activity
MC60_RS03160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MC60_RS03165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MC60_RS03170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MC60_RS03175	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MC60_RS03180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MC60_RS03205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MC60_RS03215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MC60_RS03220	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MC60_RS03225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MC60_RS03230	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
MC60_RS03235	COG3313	Fe-S protein
MC60_RS03240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MC60_RS03240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MC60_RS03240	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
MC60_RS03245	COG1105	Belongs to the carbohydrate kinase PfkB family
MC60_RS03250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MC60_RS03250	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MC60_RS03255	COG1609	Transcriptional regulator
MC60_RS03260	COG0814	amino acid
MC60_RS03270	COG5654	RES domain protein
MC60_RS03275	COG0513	Belongs to the DEAD box helicase family
MC60_RS03285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MC60_RS03290	COG2890	protein-(glutamine-N5) methyltransferase activity
MC60_RS03295	COG2840	Smr protein MutS2
MC60_RS03330	COG2824	Alkylphosphonate utilization operon protein PhnA
MC60_RS03340	COG1280	lysine exporter protein (LysE YggA)
MC60_RS03370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC60_RS03375	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MC60_RS03400	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MC60_RS03415	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MC60_RS03420	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
MC60_RS03430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MC60_RS03435	COG1434	Gram-negative-bacterium-type cell wall biogenesis
MC60_RS03445	COG0205	6-phosphofructokinase activity
MC60_RS03450	COG1473	amidohydrolase
MC60_RS03455	COG1011	Hydrolase
MC60_RS03460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MC60_RS03500	COG3593	DNA synthesis involved in DNA repair
MC60_RS03515	COG0583	DNA-binding transcription factor activity
MC60_RS03520	COG0730	response to heat
MC60_RS03530	COG3148	PFAM DTW domain containing protein
MC60_RS03535	COG1181	Belongs to the D-alanine--D-alanine ligase family
MC60_RS03545	COG0386	Belongs to the glutathione peroxidase family
MC60_RS03550	COG0513	Belongs to the DEAD box helicase family
MC60_RS03565	COG1742	UPF0060 membrane protein
MC60_RS03590	COG2329	Antibiotic biosynthesis monooxygenase
MC60_RS03595	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
MC60_RS03615	COG3243	poly(R)-hydroxyalkanoic acid synthase
MC60_RS03625	COG2501	S4 domain
MC60_RS03650	COG1132	(ABC) transporter
MC60_RS03655	COG1132	(ABC) transporter
MC60_RS03665	COG3118	belongs to the thioredoxin family
MC60_RS03670	COG0471	metal ion transport
MC60_RS03680	COG0058	SHG alpha-glucan phosphorylase activity
MC60_RS03710	COG0814	amino acid
MC60_RS03715	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
MC60_RS03720	COG0514	ATP-dependent DNA helicase (RecQ)
MC60_RS03725	COG2766	serine protein kinase
MC60_RS03730	COG2718	Belongs to the UPF0229 family
MC60_RS03735	COG2719	SpoVR family
MC60_RS03740	COG2186	Transcriptional regulator
MC60_RS03745	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MC60_RS03750	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MC60_RS03755	COG0586	Pfam SNARE associated Golgi protein
MC60_RS03765	COG0556	nucleotide-excision repair
MC60_RS03780	COG2985	domain, Protein
MC60_RS03780	COG0569	domain protein
MC60_RS03785	COG0739	heme binding
MC60_RS03785	COG0741	lytic transglycosylase activity
MC60_RS03785	COG1196	nuclear chromosome segregation
MC60_RS03805	COG4565	transcriptional regulatory protein
MC60_RS03810	COG3290	protein histidine kinase activity
MC60_RS03815	COG1940	carbohydrate kinase activity
MC60_RS03815	COG1846	Transcriptional regulator
MC60_RS03820	COG0840	transmembrane signaling receptor activity
MC60_RS03825	COG3012	SEC-C Motif Domain Protein
MC60_RS03830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MC60_RS03835	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
MC60_RS03840	COG0247	lactate metabolic process
MC60_RS03855	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
MC60_RS03860	COG0437	4 iron, 4 sulfur cluster binding
MC60_RS03865	COG3301	Polysulphide reductase, NrfD
MC60_RS03870	COG1138	Cytochrome C-type biogenesis protein
MC60_RS03875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MC60_RS03880	COG4235	cytochrome complex assembly
MC60_RS03880	COG3088	subunit of a heme lyase
MC60_RS03895	COG3046	protein related to deoxyribodipyrimidine photolyase
MC60_RS03900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MC60_RS03905	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MC60_RS03905	COG0617	tRNA 3'-terminal CCA addition
MC60_RS03905	COG0517	IMP dehydrogenase activity
MC60_RS03915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MC60_RS03920	COG0583	DNA-binding transcription factor activity
MC60_RS03930	COG4774	siderophore transport
MC60_RS03935	COG2199	diguanylate cyclase activity
MC60_RS03935	COG2203	Gaf domain
MC60_RS03940	COG2200	EAL domain
MC60_RS03945	COG4977	sequence-specific DNA binding
MC60_RS03945	COG1917	Cupin 2, conserved barrel domain protein
MC60_RS03950	COG0583	DNA-binding transcription factor activity
MC60_RS03955	COG2910	NAD(P)H-binding
MC60_RS03965	COG0626	cystathionine gamma-synthase activity
MC60_RS03970	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MC60_RS03990	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MC60_RS03995	COG1349	DNA-binding transcription factor activity
MC60_RS04010	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MC60_RS04030	COG1435	thymidine kinase activity
MC60_RS04035	COG1757	Na H antiporter
MC60_RS04040	COG2916	Histone family protein nucleoid-structuring protein H-NS
MC60_RS04045	COG2096	Adenosyltransferase
MC60_RS04050	COG3530	Putative quorum-sensing-regulated virulence factor
MC60_RS04055	COG0602	queuosine metabolic process
MC60_RS04060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MC60_RS04080	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MC60_RS04090	COG0776	regulation of translation
MC60_RS04095	COG0539	negative regulation of cytoplasmic translation
MC60_RS04100	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MC60_RS04105	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MC60_RS04135	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MC60_RS04140	COG5001	Diguanylate cyclase
MC60_RS04140	COG3300	MHYT domain
MC60_RS04150	COG0583	DNA-binding transcription factor activity
MC60_RS04155	COG0745	RESPONSE REGULATOR receiver
MC60_RS04180	COG4989	oxidoreductase activity
MC60_RS04185	COG0724	RNA recognition motif
MC60_RS04205	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MC60_RS04225	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MC60_RS04230	COG1360	Flagellar Motor Protein
MC60_RS04235	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MC60_RS04240	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MC60_RS04245	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MC60_RS04245	COG0649	NAD binding
MC60_RS04260	COG1034	ATP synthesis coupled electron transport
MC60_RS04265	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MC60_RS04270	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MC60_RS04275	COG0839	Belongs to the complex I subunit 6 family
MC60_RS04280	COG0713	ATP synthesis coupled electron transport
MC60_RS04290	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MC60_RS04295	COG1007	ATP synthesis coupled electron transport
MC60_RS04300	COG0047	phosphoribosylformylglycinamidine synthase activity
MC60_RS04300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MC60_RS04305	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MC60_RS04310	COG1645	bacterial-type flagellum-dependent swarming motility
MC60_RS04315	COG1160	GTP binding
MC60_RS04320	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MC60_RS04325	COG2976	Protein conserved in bacteria
MC60_RS04330	COG0124	histidyl-tRNA synthetase
MC60_RS04340	COG1426	Protein conserved in bacteria
MC60_RS04350	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MC60_RS04355	COG0105	UTP biosynthetic process
MC60_RS04360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MC60_RS04370	COG0633	Ferredoxin
MC60_RS04375	COG0443	Heat shock 70 kDa protein
MC60_RS04380	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MC60_RS04390	COG0822	iron-sulfur transferase activity
MC60_RS04395	COG1104	cysteine desulfurase activity
MC60_RS04410	COG3154	lipid carrier protein
MC60_RS04415	COG0826	peptidase U32
MC60_RS04420	COG0826	peptidase U32
MC60_RS04430	COG2897	thiosulfate sulfurtransferase activity
MC60_RS04435	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MC60_RS04440	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MC60_RS04445	COG1862	Preprotein translocase
MC60_RS04450	COG0343	queuine tRNA-ribosyltransferase activity
MC60_RS04455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MC60_RS04460	COG0517	IMP dehydrogenase activity
MC60_RS04465	COG0450	alkyl hydroperoxide reductase
MC60_RS04470	COG3634	alkyl hydroperoxide reductase activity
MC60_RS04515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MC60_RS04565	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MC60_RS04575	COG0714	Associated with various cellular activities
MC60_RS04580	COG3012	SEC-C Motif Domain Protein
MC60_RS04580	COG3318	Belongs to the UPF0149 family
MC60_RS04595	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MC60_RS04595	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MC60_RS04600	COG0509	glycine decarboxylation via glycine cleavage system
MC60_RS04605	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MC60_RS04610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MC60_RS04615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MC60_RS04635	COG2814	Major facilitator Superfamily
MC60_RS04640	COG0444	Belongs to the ABC transporter superfamily
MC60_RS04645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MC60_RS04650	COG0601	transmembrane transport
MC60_RS04660	COG0625	glutathione transferase activity
MC60_RS04665	COG0625	glutathione transferase activity
MC60_RS04675	COG0483	inositol monophosphate 1-phosphatase activity
MC60_RS04690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MC60_RS04695	COG2056	Na+-H+ antiporter family
MC60_RS04700	COG2814	Major facilitator Superfamily
MC60_RS04705	COG0583	DNA-binding transcription factor activity
MC60_RS04710	COG5001	Diguanylate cyclase
MC60_RS04725	COG2050	protein possibly involved in aromatic compounds catabolism
MC60_RS04735	COG0247	lactate metabolic process
MC60_RS04735	COG0277	FAD linked oxidase domain protein
MC60_RS04750	COG1253	flavin adenine dinucleotide binding
MC60_RS04755	COG1902	pentaerythritol trinitrate reductase activity
MC60_RS04765	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MC60_RS04770	COG0647	UMP catabolic process
MC60_RS04780	COG0367	asparagine synthase
MC60_RS04795	COG0625	glutathione transferase activity
MC60_RS04805	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
MC60_RS04820	COG0564	pseudouridine synthase activity
MC60_RS04825	COG5001	Diguanylate cyclase
MC60_RS04830	COG0840	transmembrane signaling receptor activity
MC60_RS04835	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MC60_RS04875	COG0670	Belongs to the BI1 family
MC60_RS04880	COG1289	transmembrane transporter activity
MC60_RS04885	COG2920	part of a sulfur-relay system
MC60_RS04890	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
MC60_RS04895	COG0285	dihydrofolate synthase activity
MC60_RS04900	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MC60_RS04905	COG0101	tRNA pseudouridine synthase activity
MC60_RS04915	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MC60_RS04920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MC60_RS04925	COG0671	phosphoesterase, PA-phosphatase related
MC60_RS04930	COG1464	Belongs to the NlpA lipoprotein family
MC60_RS04955	COG1119	ATPase activity
MC60_RS04970	COG0574	Belongs to the PEP-utilizing enzyme family
MC60_RS04970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MC60_RS04975	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MC60_RS04985	COG1113	amino acid transport
MC60_RS05035	COG1242	4 iron, 4 sulfur cluster binding
MC60_RS05040	COG0069	glutamate synthase activity
MC60_RS05040	COG0070	glutamate synthase
MC60_RS05040	COG0067	glutamate synthase
MC60_RS05045	COG0493	'glutamate synthase
MC60_RS05050	COG1126	abc transporter atp-binding protein
MC60_RS05055	COG0765	amino acid transport
MC60_RS05060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC60_RS05085	COG4104	PAAR repeat-containing protein
MC60_RS05095	COG0513	Belongs to the DEAD box helicase family
MC60_RS05120	COG3706	GGDEF domain
MC60_RS05125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MC60_RS05130	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MC60_RS05135	COG0505	Belongs to the CarA family
MC60_RS05140	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MC60_RS05150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MC60_RS05155	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MC60_RS05160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MC60_RS05165	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MC60_RS05170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MC60_RS05180	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
MC60_RS05185	COG4139	cobalamin transport
MC60_RS05210	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MC60_RS05220	COG0023	Translation Initiation Factor
MC60_RS05225	COG2119	membrane
MC60_RS05260	COG2203	Gaf domain
MC60_RS05260	COG2199	diguanylate cyclase activity
MC60_RS05285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MC60_RS05295	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MC60_RS05300	COG2261	transglycosylase associated protein
MC60_RS05305	COG1309	transcriptional regulator
MC60_RS05310	COG0604	alcohol dehydrogenase
MC60_RS05325	COG0582	viral genome integration into host DNA
MC60_RS05460	COG1328	CTP reductase activity
MC60_RS05465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MC60_RS05470	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
MC60_RS05570	COG0322	excinuclease ABC activity
MC60_RS05575	COG2197	response regulator
MC60_RS05580	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MC60_RS05585	COG2835	tetraacyldisaccharide 4'-kinase activity
MC60_RS05590	COG1663	tetraacyldisaccharide 4'-kinase activity
MC60_RS05595	COG1132	(ABC) transporter
MC60_RS05600	COG2333	competence protein COMEC
MC60_RS05600	COG0658	competence protein
MC60_RS05615	COG0433	COG0433 Predicted ATPase
MC60_RS05620	COG1448	Aminotransferase
MC60_RS05635	COG1199	ATP-dependent helicase activity
MC60_RS05645	COG0123	including yeast histone deacetylase and acetoin utilization protein
MC60_RS05650	COG0477	Major facilitator Superfamily
MC60_RS05655	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MC60_RS05660	COG1785	Belongs to the alkaline phosphatase family
MC60_RS05680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MC60_RS05685	COG3706	GGDEF domain
MC60_RS05690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC60_RS05695	COG0765	amino acid transport
MC60_RS05700	COG1126	abc transporter atp-binding protein
MC60_RS05710	COG0531	amino acid
MC60_RS05725	COG1253	flavin adenine dinucleotide binding
MC60_RS05730	COG0704	Plays a role in the regulation of phosphate uptake
MC60_RS05735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MC60_RS05740	COG0581	inorganic phosphate transmembrane transporter activity
MC60_RS05745	COG0573	inorganic phosphate transmembrane transporter activity
MC60_RS05750	COG0590	tRNA wobble adenosine to inosine editing
MC60_RS05765	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MC60_RS05785	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MC60_RS05790	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MC60_RS05795	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MC60_RS05800	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MC60_RS05825	COG2716	regulation of RNA biosynthetic process
MC60_RS05830	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MC60_RS05840	COG2239	Acts as a magnesium transporter
MC60_RS05855	COG1705	Flagellar rod assembly protein muramidase FlgJ
MC60_RS05855	COG3951	Flagellar rod assembly protein muramidase FlgJ
MC60_RS05860	COG1706	bacterial-type flagellum-dependent cell motility
MC60_RS05865	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MC60_RS05880	COG1749	Flagellar hook protein flgE
MC60_RS05895	COG1815	bacterial-type flagellum-dependent cell motility
MC60_RS05900	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MC60_RS05905	COG0784	Response regulator, receiver
MC60_RS05905	COG0835	chemotaxis
MC60_RS05910	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
MC60_RS05925	COG0622	Phosphoesterase
MC60_RS05930	COG4166	transmembrane transport
MC60_RS05945	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MC60_RS05955	COG0697	spore germination
MC60_RS05960	COG4166	transmembrane transport
MC60_RS05985	COG1278	Cold shock
MC60_RS06025	COG3132	Protein of unknown function, DUF480
MC60_RS06045	COG2801	Transposase and inactivated derivatives
MC60_RS06055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MC60_RS06080	COG1181	Belongs to the D-alanine--D-alanine ligase family
MC60_RS06110	COG1091	dTDP-4-dehydrorhamnose reductase activity
MC60_RS06140	COG1737	Transcriptional regulator
MC60_RS06145	COG0469	pyruvate kinase activity
MC60_RS06155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MC60_RS06160	COG1960	acyl-CoA dehydrogenase activity
MC60_RS06170	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MC60_RS06220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MC60_RS06225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MC60_RS06230	COG1309	transcriptional regulator
MC60_RS06245	COG1946	Acyl-CoA thioesterase
MC60_RS06255	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MC60_RS06265	COG0009	L-threonylcarbamoyladenylate synthase
MC60_RS06270	COG0613	PHP domain protein
MC60_RS06275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MC60_RS06280	COG0512	Glutamine amidotransferase of anthranilate synthase
MC60_RS06280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MC60_RS06285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MC60_RS06290	COG0134	indole-3-glycerol-phosphate synthase activity
MC60_RS06290	COG0135	phosphoribosylanthranilate isomerase activity
MC60_RS06295	COG0133	tryptophan synthase activity
MC60_RS06300	COG0159	tryptophan synthase activity
MC60_RS06315	COG2801	Transposase and inactivated derivatives
MC60_RS06320	COG1988	membrane-bound metal-dependent
MC60_RS06355	COG4521	taurine ABC transporter
MC60_RS06360	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MC60_RS06365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MC60_RS06370	COG2175	clavaminate synthase activity
MC60_RS06375	COG5507	3-demethylubiquinone-9 3-methyltransferase
MC60_RS06380	COG2814	Major facilitator Superfamily
MC60_RS06390	COG0109	protoheme IX farnesyltransferase activity
MC60_RS06395	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MC60_RS06400	COG1845	cytochrome c oxidase, subunit III
MC60_RS06405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MC60_RS06410	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MC60_RS06415	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MC60_RS06420	COG0583	DNA-binding transcription factor activity
MC60_RS06440	COG1846	Transcriptional regulator
MC60_RS06455	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
MC60_RS06470	COG0745	RESPONSE REGULATOR receiver
MC60_RS06480	COG0708	Exodeoxyribonuclease III
MC60_RS06490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MC60_RS06495	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MC60_RS06510	COG0095	Lipoate-protein ligase
MC60_RS06530	COG2391	methyltransferase activity
MC60_RS06550	COG0446	pyridine nucleotide-disulphide oxidoreductase
MC60_RS06560	COG1285	pathogenesis
MC60_RS06590	COG0484	heat shock protein binding
MC60_RS06595	COG0443	Heat shock 70 kDa protein
MC60_RS06600	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MC60_RS06605	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MC60_RS06610	COG3706	GGDEF domain
MC60_RS06615	COG0497	DNA recombination
MC60_RS06625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MC60_RS06630	COG0577	efflux transmembrane transporter activity
MC60_RS06630	COG1136	(ABC) transporter
MC60_RS06635	COG1538	Outer membrane efflux protein
MC60_RS06640	COG2375	cellular response to nickel ion
MC60_RS06645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MC60_RS06650	COG2916	Histone family protein nucleoid-structuring protein H-NS
MC60_RS06655	COG0583	DNA-binding transcription factor activity
MC60_RS06660	COG3048	D-serine ammonia-lyase activity
MC60_RS06670	COG0538	isocitrate dehydrogenase activity
MC60_RS06700	COG0456	acetyltransferase
MC60_RS06705	COG1187	pseudouridine synthase activity
MC60_RS06715	COG0482	sulfurtransferase activity
MC60_RS06720	COG2915	High frequency lysogenization protein hflD homolog
MC60_RS06725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MC60_RS06730	COG2850	peptidyl-arginine hydroxylation
MC60_RS06740	COG3264	Mechanosensitive ion channel
MC60_RS06740	COG1196	nuclear chromosome segregation
MC60_RS06770	COG0281	malic enzyme
MC60_RS06775	COG0746	molybdenum cofactor guanylyltransferase activity
MC60_RS06780	COG1763	Mo-molybdopterin cofactor biosynthetic process
MC60_RS06785	COG1289	transmembrane transporter activity
MC60_RS06790	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MC60_RS06820	COG3220	belongs to the UPF0276 family
MC60_RS06835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MC60_RS06850	COG2801	Transposase and inactivated derivatives
MC60_RS06865	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MC60_RS06870	COG0083	homoserine kinase activity
MC60_RS06885	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MC60_RS06890	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
MC60_RS06905	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MC60_RS06915	COG0745	RESPONSE REGULATOR receiver
MC60_RS06930	COG4988	ABC transporter
MC60_RS06935	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MC60_RS06955	COG1720	tRNA m6t6A37 methyltransferase activity
MC60_RS06970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MC60_RS06975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MC60_RS06980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MC60_RS06990	COG2190	(PTS) system
MC60_RS06995	COG3038	cytochrome b561
MC60_RS07005	COG0420	3'-5' exonuclease activity
MC60_RS07010	COG1247	-acetyltransferase
MC60_RS07015	COG2974	May be involved in recombination
MC60_RS07025	COG0405	Gamma-glutamyltransferase
MC60_RS07030	COG4651	solute:proton antiporter activity
MC60_RS07030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MC60_RS07065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MC60_RS07070	COG1917	Cupin 2, conserved barrel domain protein
MC60_RS07070	COG1396	sequence-specific DNA binding
MC60_RS07075	COG1012	belongs to the aldehyde dehydrogenase family
MC60_RS07085	COG0531	amino acid
MC60_RS07090	COG0531	amino acid
MC60_RS07100	COG1283	sodium-dependent phosphate transmembrane transporter activity
MC60_RS07110	COG3384	dioxygenase
MC60_RS07115	COG2205	protein histidine kinase activity
MC60_RS07115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC60_RS07140	COG0784	Response regulator, receiver
MC60_RS07140	COG2205	protein histidine kinase activity
MC60_RS07150	COG1376	ErfK ybiS ycfS ynhG family protein
MC60_RS07150	COG1388	LysM domain
MC60_RS07165	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
MC60_RS07170	COG0791	NLP P60 protein
MC60_RS07180	COG3118	belongs to the thioredoxin family
MC60_RS07190	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MC60_RS07195	COG0788	formyltetrahydrofolate deformylase activity
MC60_RS07220	COG0739	heme binding
MC60_RS07220	COG1196	nuclear chromosome segregation
MC60_RS07220	COG0741	lytic transglycosylase activity
MC60_RS07230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MC60_RS07235	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MC60_RS07240	COG0673	inositol 2-dehydrogenase activity
MC60_RS07265	COG1032	radical SAM domain protein
MC60_RS07270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MC60_RS07280	COG3706	GGDEF domain
MC60_RS07285	COG1752	Esterase of the alpha-beta hydrolase superfamily
MC60_RS07290	COG0733	neurotransmitter:sodium symporter activity
MC60_RS07320	COG0281	malic enzyme
MC60_RS07325	COG2207	Transcriptional regulator
MC60_RS07345	COG2233	PERMEase
MC60_RS07350	COG0095	Lipoate-protein ligase
MC60_RS07355	COG1115	amino acid carrier protein
MC60_RS07360	COG0019	diaminopimelate decarboxylase activity
MC60_RS07370	COG0678	peroxiredoxin activity
MC60_RS07375	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MC60_RS07385	COG1126	abc transporter atp-binding protein
MC60_RS07390	COG0765	amino acid transport
MC60_RS07395	COG4597	amino acid ABC transporter
MC60_RS07400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC60_RS07410	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MC60_RS07415	COG1131	(ABC) transporter
MC60_RS07420	COG0545	Peptidyl-prolyl cis-trans isomerase
MC60_RS07440	COG1940	carbohydrate kinase activity
MC60_RS07450	COG4783	chaperone-mediated protein folding
MC60_RS07460	COG5002	protein histidine kinase activity
MC60_RS07465	COG0745	RESPONSE REGULATOR receiver
MC60_RS07470	COG0346	lactoylglutathione lyase activity
MC60_RS07475	COG3706	GGDEF domain
MC60_RS07480	COG3284	Transcriptional regulator
MC60_RS07495	COG0697	spore germination
MC60_RS07505	COG3290	protein histidine kinase activity
MC60_RS07515	COG1566	PFAM secretion protein HlyD family protein
MC60_RS07540	COG0602	queuosine metabolic process
MC60_RS07545	COG1328	CTP reductase activity
MC60_RS07555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MC60_RS07560	COG3115	cell septum assembly
MC60_RS07565	COG1196	nuclear chromosome segregation
MC60_RS07575	COG2860	membrane
MC60_RS07585	COG3108	Peptidase M15
MC60_RS07590	COG2989	Protein conserved in bacteria
MC60_RS07605	COG0463	Glycosyl transferase, family 2
MC60_RS07620	COG0366	Alpha amylase catalytic
MC60_RS07630	COG0366	Alpha amylase catalytic
MC60_RS07675	COG3706	GGDEF domain
MC60_RS07680	COG0037	tRNA processing
MC60_RS07685	COG3590	peptidase
MC60_RS07695	COG0488	(ABC) transporter
MC60_RS07705	COG0531	amino acid
MC60_RS07710	COG0814	amino acid
MC60_RS07725	COG0825	malonyl-CoA metabolic process
MC60_RS07735	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MC60_RS07740	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MC60_RS07745	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MC60_RS07750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MC60_RS07755	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MC60_RS07770	COG0750	zinc metalloprotease
MC60_RS07775	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MC60_RS07780	COG0575	Belongs to the CDS family
MC60_RS07785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MC60_RS07790	COG0233	cytoplasmic translational termination
MC60_RS07795	COG0528	UMP kinase activity
MC60_RS07800	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MC60_RS07805	COG0052	Belongs to the universal ribosomal protein uS2 family
MC60_RS07810	COG0024	Methionine aminopeptidase
MC60_RS07815	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MC60_RS07820	COG2171	N-acyltransferase activity
MC60_RS07830	COG1263	PTS System
MC60_RS07830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC60_RS07840	COG4580	involved in the transport of maltose and maltodextrins
MC60_RS07850	COG0564	pseudouridine synthase activity
MC60_RS07855	COG3098	single-species biofilm formation
MC60_RS07880	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
MC60_RS07890	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MC60_RS07890	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MC60_RS07905	COG1611	Belongs to the LOG family
MC60_RS07910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MC60_RS07915	COG0473	3-isopropylmalate dehydrogenase activity
MC60_RS07925	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
MC60_RS07940	COG0583	DNA-binding transcription factor activity
MC60_RS07945	COG0840	transmembrane signaling receptor activity
MC60_RS07950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MC60_RS07965	COG1477	protein flavinylation
MC60_RS07970	COG2871	sodium ion transport
MC60_RS07975	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MC60_RS07980	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MC60_RS07985	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MC60_RS07990	COG1805	sodium ion transport
MC60_RS07995	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MC60_RS08000	COG0271	Belongs to the BolA IbaG family
MC60_RS08005	COG2813	Specifically methylates the guanine in position
MC60_RS08015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MC60_RS08025	COG2211	Major facilitator Superfamily
MC60_RS08030	COG3248	Nucleoside-binding outer membrane protein
MC60_RS08035	COG1666	GTP binding
MC60_RS08090	COG4104	PAAR repeat-containing protein
MC60_RS08105	COG2771	luxR family
MC60_RS08110	COG0659	secondary active sulfate transmembrane transporter activity
MC60_RS08115	COG5002	protein histidine kinase activity
MC60_RS08115	COG5000	phosphorelay sensor kinase activity
MC60_RS08120	COG0745	RESPONSE REGULATOR receiver
MC60_RS08125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MC60_RS08130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MC60_RS08150	COG1609	Transcriptional regulator
MC60_RS08155	COG2182	Extracellular solute-binding protein
MC60_RS08165	COG1472	Belongs to the glycosyl hydrolase 3 family
MC60_RS08170	COG5297	Belongs to the glycosyl hydrolase family 6
MC60_RS08170	COG2273	Hydrolase Family 16
MC60_RS08175	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MC60_RS08185	COG2723	6-phospho-beta-galactosidase activity
MC60_RS08190	COG1447	Phosphotransferase system cellobiose-specific component IIA
MC60_RS08210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MC60_RS08220	COG1151	hydroxylamine reductase activity
MC60_RS08225	COG0783	Belongs to the Dps family
MC60_RS08250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MC60_RS08265	COG4221	oxidoreductase activity
MC60_RS08275	COG0415	Belongs to the DNA photolyase family
MC60_RS08280	COG0789	Transcriptional regulator
MC60_RS08285	COG3272	Protein of unknown function (DUF1722)
MC60_RS08310	COG0077	Prephenate dehydratase
MC60_RS08310	COG1605	Chorismate mutase
MC60_RS08335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MC60_RS08350	COG0457	Tetratricopeptide repeat
MC60_RS08365	COG2133	pyrroloquinoline quinone binding
MC60_RS08375	COG1349	DNA-binding transcription factor activity
MC60_RS08380	COG2084	Dehydrogenase
MC60_RS08385	COG3395	kinase activity
MC60_RS08390	COG0235	Class ii aldolase
MC60_RS08395	COG3622	Belongs to the hyi family
MC60_RS08400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MC60_RS08405	COG2610	gluconate transmembrane transporter activity
MC60_RS08415	COG0840	transmembrane signaling receptor activity
MC60_RS08425	COG0300	oxidoreductase activity
MC60_RS08450	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MC60_RS08470	COG3813	Protein conserved in bacteria
MC60_RS08480	COG0826	peptidase U32
MC60_RS08485	COG1280	lysine exporter protein (LysE YggA)
MC60_RS08495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MC60_RS08520	COG2199	diguanylate cyclase activity
MC60_RS08520	COG2200	EAL domain
MC60_RS08520	COG2203	Gaf domain
MC60_RS08565	COG1566	PFAM secretion protein HlyD family protein
MC60_RS08575	COG0114	fumarate hydratase activity
MC60_RS08585	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MC60_RS08585	COG0506	proline dehydrogenase activity
MC60_RS08585	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MC60_RS08590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MC60_RS08605	COG0737	Belongs to the 5'-nucleotidase family
MC60_RS08625	COG2204	response regulator
MC60_RS08630	COG0545	Peptidyl-prolyl cis-trans isomerase
MC60_RS08640	COG2900	Belongs to the SlyX family
MC60_RS08645	COG1047	Peptidyl-prolyl cis-trans
MC60_RS08650	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
MC60_RS08660	COG0835	chemotaxis
MC60_RS08660	COG0784	Response regulator, receiver
MC60_RS08665	COG0429	hydrolase of the alpha beta-hydrolase fold
MC60_RS08670	COG3706	GGDEF domain
MC60_RS08670	COG4251	negative regulation of phosphorylation
MC60_RS08670	COG5001	Diguanylate cyclase
MC60_RS08670	COG2203	Gaf domain
MC60_RS08675	COG3089	Belongs to the UPF0270 family
MC60_RS08680	COG3954	Phosphoribulokinase
MC60_RS08695	COG1765	OsmC-like protein
MC60_RS08705	COG2226	methyltransferase
MC60_RS08715	COG2205	protein histidine kinase activity
MC60_RS08715	COG2202	Pas domain
MC60_RS08720	COG2814	Major facilitator Superfamily
MC60_RS08745	COG0748	coenzyme F420 binding
MC60_RS08750	COG3721	Heme iron utilization protein
MC60_RS08760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC60_RS08785	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MC60_RS08795	COG0463	Glycosyl transferase, family 2
MC60_RS08805	COG0741	lytic transglycosylase activity
MC60_RS08810	COG0488	(ABC) transporter
MC60_RS08820	COG2252	PERMEase
MC60_RS08825	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MC60_RS08830	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MC60_RS08835	COG3178	'Phosphotransferase
MC60_RS08840	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MC60_RS08850	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MC60_RS08855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MC60_RS08860	COG2967	ApaG domain
MC60_RS08865	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MC60_RS08875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MC60_RS08880	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MC60_RS08885	COG3314	Sporulation integral membrane protein YlbJ
MC60_RS08890	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MC60_RS08895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MC60_RS08900	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MC60_RS08905	COG0142	geranyltranstransferase activity
MC60_RS08910	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
MC60_RS08915	COG0330	HflC and HflK could
MC60_RS08920	COG0330	HflC and HflK could
MC60_RS08925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MC60_RS08930	COG1923	regulation of RNA biosynthetic process
MC60_RS08935	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MC60_RS08940	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MC60_RS08950	COG0802	atpase or kinase
MC60_RS08955	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MC60_RS08955	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MC60_RS08975	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MC60_RS08980	COG2011	ABC-type metal ion transport system permease component
MC60_RS08985	COG1464	Belongs to the NlpA lipoprotein family
MC60_RS09005	COG2205	protein histidine kinase activity
MC60_RS09005	COG0784	Response regulator, receiver
MC60_RS09015	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MC60_RS09020	COG0784	Response regulator, receiver
MC60_RS09020	COG2198	Histidine kinase
MC60_RS09020	COG5002	protein histidine kinase activity
MC60_RS09040	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
MC60_RS09055	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MC60_RS09060	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
MC60_RS09065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MC60_RS09070	COG2716	regulation of RNA biosynthetic process
MC60_RS09075	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MC60_RS09080	COG3013	Belongs to the UPF0304 family
MC60_RS09090	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MC60_RS09095	COG0857	belongs to the CobB CobQ family
MC60_RS09095	COG0280	phosphate acetyltransferase
MC60_RS09100	COG0440	acetolactate synthase activity
MC60_RS09105	COG0028	Belongs to the TPP enzyme family
MC60_RS09120	COG0671	phosphoesterase, PA-phosphatase related
MC60_RS09130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MC60_RS09135	COG0473	3-isopropylmalate dehydrogenase activity
MC60_RS09140	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MC60_RS09145	COG0066	3-isopropylmalate dehydratase activity
MC60_RS09160	COG4143	(ABC) transporter
MC60_RS09165	COG1178	ABC-type Fe3 transport system permease component
MC60_RS09170	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
MC60_RS09175	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MC60_RS09185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MC60_RS09240	COG2205	protein histidine kinase activity
MC60_RS09245	COG0745	RESPONSE REGULATOR receiver
MC60_RS09250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MC60_RS09255	COG0577	efflux transmembrane transporter activity
MC60_RS09255	COG1136	(ABC) transporter
MC60_RS09265	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
MC60_RS09300	COG2203	Gaf domain
MC60_RS09300	COG2199	diguanylate cyclase activity
MC60_RS09305	COG0513	Belongs to the DEAD box helicase family
MC60_RS09315	COG1917	Cupin 2, conserved barrel domain protein
MC60_RS09315	COG2207	Transcriptional regulator
MC60_RS09345	COG0154	amidase activity
MC60_RS09350	COG2957	Belongs to the agmatine deiminase family
MC60_RS09365	COG1902	pentaerythritol trinitrate reductase activity
MC60_RS09370	COG0456	acetyltransferase
MC60_RS09395	COG5001	Diguanylate cyclase
MC60_RS09395	COG5002	protein histidine kinase activity
MC60_RS09400	COG2425	protein containing a von Willebrand factor type A (vWA) domain
MC60_RS09415	COG0456	acetyltransferase
MC60_RS09425	COG1022	Amp-dependent synthetase and ligase
MC60_RS09435	COG1794	racemase activity, acting on amino acids and derivatives
MC60_RS09450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC60_RS09465	COG0733	neurotransmitter:sodium symporter activity
MC60_RS09470	COG0733	neurotransmitter:sodium symporter activity
MC60_RS09485	COG0561	phosphatase activity
MC60_RS09515	COG1846	Transcriptional regulator
MC60_RS09520	COG2130	NADP-dependent
MC60_RS09550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MC60_RS09555	COG1640	4-alpha-glucanotransferase
MC60_RS09560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MC60_RS09570	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MC60_RS09575	COG0840	transmembrane signaling receptor activity
MC60_RS09650	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
MC60_RS09655	COG2885	chlorophyll binding
MC60_RS09660	COG0823	Involved in the tonB-independent uptake of proteins
MC60_RS09675	COG0811	peptide transport
MC60_RS09680	COG0824	Thioesterase
MC60_RS09685	COG3790	cyd operon protein YbgE
MC60_RS09690	COG4890	Cyd operon protein YbgT
MC60_RS09695	COG1294	oxidase, subunit
MC60_RS09700	COG1271	oxidase subunit
MC60_RS09705	COG2255	four-way junction helicase activity
MC60_RS09710	COG0632	four-way junction helicase activity
MC60_RS09715	COG0840	transmembrane signaling receptor activity
MC60_RS09720	COG0442	prolyl-tRNA aminoacylation
MC60_RS09725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MC60_RS09730	COG4221	oxidoreductase activity
MC60_RS09745	COG1024	Enoyl-CoA hydratase
MC60_RS09760	COG4166	transmembrane transport
MC60_RS09770	COG0840	transmembrane signaling receptor activity
MC60_RS09775	COG0513	Belongs to the DEAD box helicase family
MC60_RS09810	COG0457	Tetratricopeptide repeat
MC60_RS09810	COG3118	belongs to the thioredoxin family
MC60_RS09820	COG1215	transferase activity, transferring glycosyl groups
MC60_RS09840	COG2194	sulfuric ester hydrolase activity
MC60_RS09845	COG1448	Aminotransferase
MC60_RS09860	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MC60_RS09865	COG1328	CTP reductase activity
MC60_RS09895	COG3397	chitin binding
MC60_RS09900	COG0583	DNA-binding transcription factor activity
MC60_RS09905	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MC60_RS09910	COG4208	sulfate ABC transporter
MC60_RS09915	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MC60_RS09925	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MC60_RS09960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MC60_RS09965	COG0564	pseudouridine synthase activity
MC60_RS09985	COG0459	protein refolding
MC60_RS09990	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MC60_RS09995	COG0534	Mate efflux family protein
MC60_RS10000	COG3030	protein affecting phage T7 exclusion by the F plasmid
MC60_RS10005	COG1027	Aspartate ammonia-lyase
MC60_RS10010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MC60_RS10015	COG2918	glutathione biosynthetic process
MC60_RS10020	COG0612	Peptidase, M16
MC60_RS10025	COG1238	metal cluster binding
MC60_RS10065	COG0359	binds to the 23S rRNA
MC60_RS10070	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MC60_RS10075	COG0360	Binds together with S18 to 16S ribosomal RNA
MC60_RS10080	COG1914	H( )-stimulated, divalent metal cation uptake system
MC60_RS10090	COG2153	protein acetylation
MC60_RS10100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MC60_RS10105	COG0557	exoribonuclease II activity
MC60_RS10110	COG3706	GGDEF domain
MC60_RS10115	COG1854	S-ribosylhomocysteine lyase activity
MC60_RS10130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MC60_RS10130	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MC60_RS10170	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MC60_RS10175	COG1047	Peptidyl-prolyl cis-trans
MC60_RS10180	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MC60_RS10185	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MC60_RS10190	COG0196	riboflavin kinase activity
MC60_RS10195	COG0728	peptidoglycan biosynthetic process
MC60_RS10200	COG0268	Binds directly to 16S ribosomal RNA
MC60_RS10205	COG0640	Transcriptional regulator
MC60_RS10210	COG0583	DNA-binding transcription factor activity
MC60_RS10220	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MC60_RS10225	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MC60_RS10230	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MC60_RS10240	COG1051	belongs to the nudix hydrolase family
MC60_RS10255	COG0335	large ribosomal subunit rRNA binding
MC60_RS10260	COG0336	Belongs to the RNA methyltransferase TrmD family
MC60_RS10265	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MC60_RS10270	COG0228	four-way junction DNA binding
MC60_RS10275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MC60_RS10280	COG4137	Cytochrome C assembly protein
MC60_RS10285	COG4536	flavin adenine dinucleotide binding
MC60_RS10295	COG1017	nitric oxide dioxygenase activity
MC60_RS10295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MC60_RS10300	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
MC60_RS10305	COG0039	L-malate dehydrogenase activity
MC60_RS10310	COG4160	amino acid transport
MC60_RS10315	COG4215	(ABC) transporter
MC60_RS10320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC60_RS10325	COG1126	abc transporter atp-binding protein
MC60_RS10330	COG1438	arginine binding
MC60_RS10335	COG2837	iron assimilation
MC60_RS10340	COG3842	ATPase activity
MC60_RS10355	COG0347	Belongs to the P(II) protein family
MC60_RS10370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC60_RS10375	COG0583	DNA-binding transcription factor activity
MC60_RS10390	COG1929	Belongs to the glycerate kinase type-1 family
MC60_RS10395	COG2610	gluconate transmembrane transporter activity
MC60_RS10400	COG3835	regulator
MC60_RS10405	COG3112	Uncharacterised protein family (UPF0231)
MC60_RS10425	COG1872	DUF167
MC60_RS10430	COG0762	integral membrane protein
MC60_RS10435	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MC60_RS10440	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MC60_RS10455	COG3022	response to hydroperoxide
MC60_RS10460	COG0513	Belongs to the DEAD box helicase family
MC60_RS10465	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MC60_RS10485	COG0735	belongs to the Fur family
MC60_RS10490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MC60_RS10505	COG0776	regulation of translation
MC60_RS10510	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
MC60_RS10520	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MC60_RS10535	COG0560	Phosphoserine phosphatase
MC60_RS10545	COG3447	MASE1 domain protein
MC60_RS10545	COG5002	protein histidine kinase activity
MC60_RS10545	COG5001	Diguanylate cyclase
MC60_RS10550	COG4520	surface antigen
MC60_RS10560	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MC60_RS10565	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MC60_RS10570	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MC60_RS10580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC60_RS10585	COG0084	hydrolase, TatD family'
MC60_RS10590	COG2165	general secretion pathway protein
MC60_RS10600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MC60_RS10610	COG0004	ammonium transporteR
MC60_RS10630	COG0795	lipopolysaccharide-transporting ATPase activity
MC60_RS10635	COG0795	lipopolysaccharide-transporting ATPase activity
MC60_RS10640	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MC60_RS10645	COG2927	DNA polymerase III (CHI subunit)
MC60_RS10650	COG0525	valine-tRNA ligase activity
MC60_RS10655	COG1253	flavin adenine dinucleotide binding
MC60_RS10660	COG0586	Pfam SNARE associated Golgi protein
MC60_RS10665	COG1686	Belongs to the peptidase S11 family
MC60_RS10700	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MC60_RS10705	COG0527	aspartate kinase activity
MC60_RS10710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MC60_RS10715	COG2137	regulation of response to DNA damage stimulus
MC60_RS10720	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MC60_RS10725	COG1546	Belongs to the CinA family
MC60_RS10735	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MC60_RS10755	COG3068	Protein conserved in bacteria
MC60_RS10765	COG0739	heme binding
MC60_RS10785	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
MC60_RS10790	COG1121	(ABC) transporter
MC60_RS10795	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MC60_RS10800	COG0583	DNA-binding transcription factor activity
MC60_RS10810	COG1573	uracil-dna glycosylase
MC60_RS10815	COG2962	Rard protein
MC60_RS10820	COG2827	Endonuclease containing a URI domain
MC60_RS10835	COG1842	Phage shock protein A
MC60_RS10840	COG0204	Acyl-transferase
MC60_RS10860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MC60_RS10870	COG0484	heat shock protein binding
MC60_RS10915	COG1289	transmembrane transporter activity
MC60_RS10920	COG1566	PFAM secretion protein HlyD family protein
MC60_RS10935	COG1051	belongs to the nudix hydrolase family
MC60_RS10940	COG3150	esterase
MC60_RS10950	COG3151	Protein conserved in bacteria
MC60_RS10955	COG0494	nUDIX hydrolase
MC60_RS10960	COG1538	Outer membrane efflux protein
MC60_RS10965	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MC60_RS10965	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MC60_RS10970	COG1560	Kdo2-lipid A biosynthetic process
MC60_RS10985	COG2771	luxR family
MC60_RS10990	COG3916	Acyl-homoserine-lactone synthase
MC60_RS11000	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
MC60_RS11005	COG2213	PTS system mannitol-specific
MC60_RS11005	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MC60_RS11010	COG0246	Mannitol dehydrogenase
MC60_RS11015	COG3722	fumarate hydratase activity
MC60_RS11020	COG3263	regulation of cellular component size
MC60_RS11040	COG1671	Belongs to the UPF0178 family
MC60_RS11055	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC60_RS11060	COG0513	Belongs to the DEAD box helicase family
MC60_RS11080	COG1575	Belongs to the MenA family. Type 1 subfamily
MC60_RS11085	COG1169	isochorismate synthase
MC60_RS11090	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MC60_RS11095	COG0596	Alpha beta hydrolase
MC60_RS11100	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MC60_RS11110	COG0318	PFAM AMP-dependent synthetase and ligase
MC60_RS11120	COG2949	membrane
MC60_RS11125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MC60_RS11135	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MC60_RS11165	COG2873	o-acetylhomoserine
MC60_RS11175	COG1979	alcohol dehydrogenase
MC60_RS11190	COG4221	oxidoreductase activity
MC60_RS11210	COG1285	pathogenesis
MC60_RS11225	COG1368	sulfuric ester hydrolase activity
MC60_RS11230	COG1522	sequence-specific DNA binding
MC60_RS11240	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
MC60_RS11250	COG1058	Belongs to the CinA family
MC60_RS11250	COG1546	Belongs to the CinA family
MC60_RS11255	COG1988	membrane-bound metal-dependent
MC60_RS11270	COG0561	phosphatase activity
MC60_RS11275	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MC60_RS11285	COG1011	Hydrolase
MC60_RS11300	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MC60_RS11305	COG0019	diaminopimelate decarboxylase activity
MC60_RS11315	COG1965	Belongs to the frataxin family
MC60_RS11320	COG0400	carboxylic ester hydrolase activity
MC60_RS11325	COG3072	Adenylate cyclase
MC60_RS11330	COG0181	hydroxymethylbilane synthase activity
MC60_RS11340	COG2959	enzyme of heme biosynthesis
MC60_RS11345	COG3071	HemY protein
MC60_RS11355	COG1494	fructose-1,6-bisphosphatase
MC60_RS11365	COG2226	methyltransferase
MC60_RS11390	COG1733	regulation of RNA biosynthetic process
MC60_RS11410	COG3932	Exopolysaccharide synthesis, ExoD
MC60_RS11425	COG0110	maltose O-acetyltransferase activity
MC60_RS11435	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MC60_RS11440	COG2022	thiamine diphosphate biosynthetic process
MC60_RS11450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MC60_RS11455	COG0352	thiamine-phosphate diphosphorylase activity
MC60_RS11460	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MC60_RS11475	COG0745	RESPONSE REGULATOR receiver
MC60_RS11480	COG0642	Histidine kinase
MC60_RS11485	COG0189	ligase activity
MC60_RS11520	COG2321	neutral zinc metallopeptidase
MC60_RS11530	COG0477	Major facilitator Superfamily
MC60_RS11545	COG0312	modulator of DNA gyrase
MC60_RS11550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MC60_RS11555	COG3164	Protein of unknown function
MC60_RS11560	COG1530	ribonuclease E activity
MC60_RS11565	COG0424	maF-like protein
MC60_RS11570	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MC60_RS11575	COG1792	Involved in formation and maintenance of cell shape
MC60_RS11580	COG1077	Cell shape determining protein MreB Mrl
MC60_RS11625	COG1459	type II secretion system
MC60_RS11630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MC60_RS11680	COG2200	EAL domain
MC60_RS11685	COG0387	Pfam Sodium calcium exchanger
MC60_RS11690	COG2986	histidine ammonia-lyase
MC60_RS11695	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MC60_RS11700	COG0010	Belongs to the arginase family
MC60_RS11705	COG1228	amidohydrolase
MC60_RS11710	COG2188	Transcriptional regulator
MC60_RS11715	COG0288	reversible hydration of carbon dioxide
MC60_RS11725	COG2177	Part of the ABC transporter FtsEX involved in
MC60_RS11730	COG2884	Cell division ATP-binding protein ftsE
MC60_RS11735	COG0552	protein localization to endoplasmic reticulum
MC60_RS11740	COG0742	ribosomal rna small subunit methyltransferase
MC60_RS11765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MC60_RS11770	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MC60_RS11780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MC60_RS11790	COG2095	MarC family integral membrane protein
MC60_RS11800	COG1301	dicarboxylic acid transport
MC60_RS11810	COG0583	DNA-binding transcription factor activity
MC60_RS11825	COG3714	YhhN family
MC60_RS11840	COG2358	TRAP transporter, solute receptor (TAXI family
MC60_RS11845	COG1770	oligopeptidase
MC60_RS11860	COG4221	oxidoreductase activity
MC60_RS11865	COG0583	DNA-binding transcription factor activity
MC60_RS11870	COG2249	NAD(P)H dehydrogenase (quinone) activity
MC60_RS11925	COG0203	ribosomal protein L17
MC60_RS11930	COG0202	RNA polymerase activity
MC60_RS11935	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MC60_RS11940	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MC60_RS11945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MC60_RS11950	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MC60_RS11955	COG0201	protein transport
MC60_RS11960	COG0200	Binds to the 23S rRNA
MC60_RS11965	COG1841	ribosomal large subunit assembly
MC60_RS11970	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MC60_RS11975	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MC60_RS11980	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MC60_RS11985	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MC60_RS11990	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MC60_RS11995	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MC60_RS12000	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MC60_RS12005	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MC60_RS12010	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MC60_RS12015	COG0255	Belongs to the universal ribosomal protein uL29 family
MC60_RS12020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MC60_RS12025	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MC60_RS12030	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MC60_RS12035	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MC60_RS12040	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MC60_RS12045	COG0089	rRNA binding
MC60_RS12050	COG0088	Forms part of the polypeptide exit tunnel
MC60_RS12055	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MC60_RS12060	COG0051	transcription antitermination factor activity, RNA binding
MC60_RS12070	COG2205	protein histidine kinase activity
MC60_RS12080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MC60_RS12085	COG2183	response to ionizing radiation
MC60_RS12100	COG0596	Alpha beta hydrolase
MC60_RS12105	COG1040	competence protein
MC60_RS12110	COG0316	Belongs to the HesB IscA family
MC60_RS12110	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MC60_RS12115	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MC60_RS12120	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MC60_RS12125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC60_RS12130	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MC60_RS12135	COG4942	peptidase
MC60_RS12145	COG1609	Transcriptional regulator
MC60_RS12160	COG0800	Aldolase
MC60_RS12165	COG0129	dihydroxy-acid dehydratase activity
MC60_RS12170	COG3265	gluconokinase activity
MC60_RS12175	COG2610	gluconate transmembrane transporter activity
MC60_RS12180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MC60_RS12185	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MC60_RS12195	COG0456	acetyltransferase
MC60_RS12205	COG1490	D-aminoacyl-tRNA deacylase activity
MC60_RS12210	COG1295	ribonuclease BN
MC60_RS12215	COG1217	gtp-binding protein TYPA
MC60_RS12220	COG0174	glutamine synthetase
MC60_RS12230	COG3852	Histidine kinase
MC60_RS12240	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MC60_RS12245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MC60_RS12255	COG3078	GTPase activator activity
MC60_RS12265	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MC60_RS12270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MC60_RS12275	COG0408	coproporphyrinogen oxidase activity
MC60_RS12280	COG0009	L-threonylcarbamoyladenylate synthase
MC60_RS12285	COG0551	DNA topoisomerase type I activity
MC60_RS12290	COG2922	Belongs to the Smg family
MC60_RS12295	COG0758	DNA mediated transformation
MC60_RS12305	COG0242	peptide deformylase activity
MC60_RS12310	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MC60_RS12315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MC60_RS12315	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MC60_RS12320	COG0569	domain protein
MC60_RS12325	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MC60_RS12330	COG1322	Protein conserved in bacteria
MC60_RS12350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MC60_RS12360	COG0519	Catalyzes the synthesis of GMP from XMP
MC60_RS12360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MC60_RS12370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MC60_RS12375	COG1396	sequence-specific DNA binding
MC60_RS12380	COG1012	belongs to the aldehyde dehydrogenase family
MC60_RS12385	COG2962	Rard protein
MC60_RS12395	COG1280	lysine exporter protein (LysE YggA)
MC60_RS12410	COG0583	DNA-binding transcription factor activity
MC60_RS12445	COG0583	DNA-binding transcription factor activity
MC60_RS12450	COG1943	Transposase
MC60_RS12460	COG0210	DNA helicase
MC60_RS12475	COG1744	ABC transporter substrate-binding protein PnrA-like
MC60_RS12480	COG3845	ABC transporter
MC60_RS12485	COG4603	Belongs to the binding-protein-dependent transport system permease family
MC60_RS12490	COG1079	Belongs to the binding-protein-dependent transport system permease family
MC60_RS12495	COG0583	DNA-binding transcription factor activity
MC60_RS12520	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MC60_RS12525	COG0385	Bile acid
MC60_RS12530	COG0531	amino acid
MC60_RS12535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MC60_RS12540	COG0531	amino acid
MC60_RS12545	COG2731	YhcH YjgK YiaL family protein
MC60_RS12550	COG3250	beta-galactosidase activity
MC60_RS12555	COG1609	Transcriptional regulator
MC60_RS12590	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MC60_RS12595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MC60_RS12595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MC60_RS12600	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
MC60_RS12605	COG3074	FtsZ-dependent cytokinesis
MC60_RS12615	COG1045	serine acetyltransferase
MC60_RS12625	COG0745	RESPONSE REGULATOR receiver
MC60_RS12630	COG2205	protein histidine kinase activity
MC60_RS12635	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MC60_RS12640	COG0534	Mate efflux family protein
MC60_RS12655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MC60_RS12660	COG2937	Belongs to the GPAT DAPAT family
MC60_RS12665	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MC60_RS12670	COG3161	chorismate lyase activity
MC60_RS12675	COG1580	Controls the rotational direction of flagella during chemotaxis
MC60_RS12695	COG1609	Transcriptional regulator
MC60_RS12740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MC60_RS12750	COG0156	8-amino-7-oxononanoate synthase activity
MC60_RS12755	COG1063	alcohol dehydrogenase
MC60_RS12775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MC60_RS12780	COG2166	iron-sulfur cluster assembly
MC60_RS12785	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MC60_RS12835	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MC60_RS12840	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MC60_RS12845	COG2223	nitrite transmembrane transporter activity
MC60_RS12850	COG3279	Response regulator of the LytR AlgR family
MC60_RS12855	COG3275	phosphorelay sensor kinase activity
MC60_RS12865	COG2205	protein histidine kinase activity
MC60_RS12865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC60_RS12885	COG3188	usher protein
MC60_RS12900	COG1280	lysine exporter protein (LysE YggA)
MC60_RS12905	COG2223	nitrite transmembrane transporter activity
MC60_RS12910	COG2081	HI0933 family
MC60_RS12915	COG1528	Iron-storage protein
MC60_RS12920	COG3706	GGDEF domain
MC60_RS12925	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MC60_RS12935	COG0589	response to stress
MC60_RS12975	COG3642	lipopolysaccharide core region biosynthetic process
MC60_RS12980	COG0859	PFAM glycosyl transferase family 9
MC60_RS12995	COG1758	RNA polymerase activity
MC60_RS13000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MC60_RS13005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MC60_RS13010	COG0110	maltose O-acetyltransferase activity
MC60_RS13015	COG2267	carboxylic ester hydrolase activity
MC60_RS13020	COG0561	phosphatase activity
MC60_RS13050	COG1309	transcriptional regulator
MC60_RS13055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MC60_RS13060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MC60_RS13065	COG4191	Histidine kinase
MC60_RS13065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC60_RS13070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MC60_RS13095	COG2205	protein histidine kinase activity
MC60_RS13100	COG0745	RESPONSE REGULATOR receiver
MC60_RS13105	COG2814	Major facilitator Superfamily
MC60_RS13120	COG3977	Valine--pyruvate aminotransferase
MC60_RS13125	COG0071	Belongs to the small heat shock protein (HSP20) family
MC60_RS13130	COG0071	Belongs to the small heat shock protein (HSP20) family
MC60_RS13135	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MC60_RS13140	COG2207	Transcriptional regulator
MC60_RS13155	COG0592	DNA-directed DNA polymerase activity
MC60_RS13160	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MC60_RS13175	COG1126	abc transporter atp-binding protein
MC60_RS13180	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MC60_RS13185	COG0594	ribonuclease P activity
MC60_RS13190	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MC60_RS13195	COG0706	membrane insertase activity
MC60_RS13200	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MC60_RS13205	COG4974	Belongs to the 'phage' integrase family
MC60_RS13260	COG3550	peptidyl-serine autophosphorylation
MC60_RS13270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MC60_RS13275	COG1120	ATPase activity
MC60_RS13280	COG4615	Cyclic peptide transporter
MC60_RS13285	COG4774	siderophore transport
MC60_RS13290	COG0716	FMN binding
MC60_RS13295	COG0445	tRNA wobble uridine modification
MC60_RS13300	COG0357	Ribosomal RNA small subunit methyltransferase G
MC60_RS13305	COG1192	Involved in chromosome partitioning
MC60_RS13310	COG1475	DNA binding
MC60_RS13320	COG0356	it plays a direct role in the translocation of protons across the membrane
MC60_RS13330	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MC60_RS13335	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MC60_RS13340	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MC60_RS13345	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MC60_RS13350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MC60_RS13355	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MC60_RS13360	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MC60_RS13365	COG4452	Inner membrane protein CreD
MC60_RS13375	COG2205	protein histidine kinase activity
MC60_RS13380	COG0745	RESPONSE REGULATOR receiver
MC60_RS13385	COG1349	DNA-binding transcription factor activity
MC60_RS13390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MC60_RS13395	COG2771	luxR family
MC60_RS13405	COG0811	peptide transport
MC60_RS13410	COG0811	peptide transport
MC60_RS13415	COG0848	biopolymer transport protein
MC60_RS13420	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
MC60_RS13455	COG0402	S-adenosylhomocysteine deaminase activity
MC60_RS13460	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MC60_RS13470	COG3165	ubiquinone biosynthetic process from chorismate
MC60_RS13475	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MC60_RS13480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MC60_RS13485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MC60_RS13490	COG0805	protein transport
MC60_RS13495	COG0084	hydrolase, TatD family'
MC60_RS13505	COG0339	signal peptide processing
MC60_RS13515	COG0742	ribosomal rna small subunit methyltransferase
MC60_RS13525	COG0248	Ppx GppA phosphatase
MC60_RS13530	COG0513	Belongs to the DEAD box helicase family
MC60_RS13535	COG3118	belongs to the thioredoxin family
MC60_RS13550	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MC60_RS13560	COG2960	long-chain fatty acid transporting porin activity
MC60_RS13575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC60_RS13615	COG1609	Transcriptional regulator
MC60_RS13620	COG3604	Transcriptional regulator
MC60_RS13625	COG0426	domain, Protein
MC60_RS13625	COG1773	rubredoxin
MC60_RS13630	COG0446	pyridine nucleotide-disulphide oxidoreductase
MC60_RS13640	COG0348	domain, Protein
MC60_RS13650	COG3033	Beta-eliminating lyase
MC60_RS13655	COG0814	amino acid
MC60_RS13660	COG0814	amino acid
MC60_RS13675	COG3706	GGDEF domain
MC60_RS13675	COG4251	negative regulation of phosphorylation
MC60_RS13675	COG5001	Diguanylate cyclase
MC60_RS13675	COG2203	Gaf domain
MC60_RS13685	COG0751	glycine-tRNA ligase activity
MC60_RS13690	COG0752	glycyl-tRNA synthetase alpha subunit
MC60_RS13695	COG2818	Glycosylase
MC60_RS13700	COG1335	isochorismatase
MC60_RS13710	COG2885	chlorophyll binding
MC60_RS13730	COG0251	oxidation-reduction process
MC60_RS13735	COG0425	Belongs to the sulfur carrier protein TusA family
MC60_RS13760	COG0183	Belongs to the thiolase family
MC60_RS13765	COG1024	Enoyl-CoA hydratase
MC60_RS13765	COG1250	3-hydroxyacyl-CoA dehydrogenase
MC60_RS13770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MC60_RS13775	COG0006	proline dipeptidase activity
MC60_RS13780	COG1739	Uncharacterized protein family UPF0029
MC60_RS13785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MC60_RS13790	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
MC60_RS13820	COG1042	CoA-binding domain protein
MC60_RS13820	COG0045	succinate-CoA ligase (ADP-forming) activity
MC60_RS13820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC60_RS13830	COG0583	DNA-binding transcription factor activity
MC60_RS13835	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MC60_RS13840	COG0166	Belongs to the GPI family
MC60_RS13850	COG0668	transmembrane transport
MC60_RS13860	COG1309	transcriptional regulator
MC60_RS13865	COG0756	dUTP diphosphatase activity
MC60_RS13870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MC60_RS13875	COG2003	Belongs to the UPF0758 family
MC60_RS13880	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MC60_RS13885	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MC60_RS13895	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MC60_RS13900	COG2990	Protein conserved in bacteria
MC60_RS13905	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MC60_RS13910	COG0859	PFAM glycosyl transferase family 9
MC60_RS13915	COG0463	Glycosyl transferase, family 2
MC60_RS13920	COG0859	PFAM glycosyl transferase family 9
MC60_RS13925	COG1519	Transferase
MC60_RS13935	COG1561	YicC-like family, N-terminal region
MC60_RS13940	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MC60_RS13945	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MC60_RS13960	COG3706	GGDEF domain
MC60_RS13960	COG2203	Gaf domain
MC60_RS13960	COG4251	negative regulation of phosphorylation
MC60_RS13960	COG5001	Diguanylate cyclase
MC60_RS13965	COG3084	Protein conserved in bacteria
MC60_RS13975	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MC60_RS13980	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MC60_RS13990	COG1335	isochorismatase
MC60_RS14000	COG1683	Conserved Protein
MC60_RS14005	COG0204	Acyl-transferase
MC60_RS14010	COG0204	Acyl-transferase
MC60_RS14015	COG0606	chelatase, subunit chli
MC60_RS14030	COG3978	acetolactate synthase activity
MC60_RS14040	COG0129	dihydroxy-acid dehydratase activity
MC60_RS14060	COG1309	transcriptional regulator
MC60_RS14065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MC60_RS14070	COG0254	rRNA binding
MC60_RS14075	COG0702	epimerase
MC60_RS14080	COG0281	malic enzyme
MC60_RS14090	COG2205	protein histidine kinase activity
MC60_RS14095	COG0745	RESPONSE REGULATOR receiver
MC60_RS14100	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MC60_RS14115	COG0366	Alpha amylase catalytic
MC60_RS14130	COG0443	Heat shock 70 kDa protein
MC60_RS14135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MC60_RS14140	COG3045	CreA protein
MC60_RS14160	COG0174	glutamine synthetase
MC60_RS14180	COG3842	ATPase activity
MC60_RS14185	COG1176	ABC-type spermidine putrescine transport system, permease component I
MC60_RS14190	COG1177	transmembrane transport
MC60_RS14195	COG2258	MOSC domain
MC60_RS14210	COG2050	protein possibly involved in aromatic compounds catabolism
MC60_RS14215	COG0514	ATP-dependent DNA helicase (RecQ)
MC60_RS14225	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MC60_RS14235	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MC60_RS14240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MC60_RS14245	COG2239	Acts as a magnesium transporter
MC60_RS14250	COG1648	precorrin-2 dehydrogenase activity
MC60_RS14250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MC60_RS14255	COG2116	formate transmembrane transporter activity
MC60_RS14265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MC60_RS14270	COG0842	Transport permease protein
MC60_RS14275	COG0842	Transport permease protein
MC60_RS14280	COG1131	(ABC) transporter
MC60_RS14285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MC60_RS14300	COG0477	Major facilitator Superfamily
MC60_RS14305	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MC60_RS14310	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MC60_RS14330	COG1595	DNA-templated transcription, initiation
MC60_RS14335	COG3806	Anti-sigma factor
MC60_RS14340	COG1968	undecaprenyl-diphosphatase activity
MC60_RS14345	COG0667	Aldo Keto reductase
MC60_RS14350	COG2017	converts alpha-aldose to the beta-anomer
MC60_RS14355	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MC60_RS14365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MC60_RS14370	COG1609	Transcriptional regulator
MC60_RS14375	COG3250	beta-galactosidase activity
MC60_RS14415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MC60_RS14420	COG1288	antiporter activity
MC60_RS14425	COG1438	arginine binding
MC60_RS14430	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MC60_RS14435	COG0540	Belongs to the ATCase OTCase family
MC60_RS14460	COG0840	transmembrane signaling receptor activity
MC60_RS14470	COG3040	lipid binding
MC60_RS14475	COG2207	Transcriptional regulator
MC60_RS14480	COG1979	alcohol dehydrogenase
MC60_RS14485	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MC60_RS14490	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MC60_RS14495	COG2964	Protein conserved in bacteria
MC60_RS14500	COG3681	Belongs to the UPF0597 family
MC60_RS14505	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MC60_RS14510	COG0564	pseudouridine synthase activity
MC60_RS14520	COG0542	response to heat
MC60_RS14525	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MC60_RS14530	COG2502	aspartate--ammonia ligase
MC60_RS14535	COG1522	sequence-specific DNA binding
MC60_RS14545	COG0516	GMP reductase activity
MC60_RS14545	COG0517	IMP dehydrogenase activity
MC60_RS14565	COG2205	protein histidine kinase activity
MC60_RS14575	COG2204	response regulator
MC60_RS14590	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MC60_RS14625	COG0243	molybdopterin cofactor binding
MC60_RS14630	COG3005	denitrification pathway
MC60_RS14635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MC60_RS14640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MC60_RS14645	COG0569	domain protein
MC60_RS14650	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MC60_RS14675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MC60_RS14690	COG0250	Participates in transcription elongation, termination and antitermination
MC60_RS14695	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MC60_RS14700	COG0081	regulation of translation
MC60_RS14705	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MC60_RS14710	COG0222	ribosome binding
MC60_RS14715	COG0085	RNA polymerase activity
MC60_RS14720	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MC60_RS14725	COG2964	Protein conserved in bacteria
MC60_RS14730	COG0251	oxidation-reduction process
MC60_RS14735	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
MC60_RS14745	COG2168	tRNA wobble position uridine thiolation
MC60_RS14750	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MC60_RS14755	COG0049	tRNA binding
MC60_RS14760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MC60_RS14765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MC60_RS14770	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MC60_RS14805	COG2252	PERMEase
MC60_RS14810	COG2376	Dihydroxyacetone kinase
MC60_RS14815	COG1461	Dihydroxyacetone kinase
MC60_RS14830	COG0583	DNA-binding transcription factor activity
MC60_RS14835	COG2957	Belongs to the agmatine deiminase family
MC60_RS14850	COG2957	Belongs to the agmatine deiminase family
MC60_RS14860	COG0628	permease
MC60_RS14865	COG0494	nUDIX hydrolase
MC60_RS14890	COG0753	catalase activity
MC60_RS14895	COG0456	acetyltransferase
MC60_RS14925	COG3842	ATPase activity
MC60_RS14935	COG1175	transmembrane transport
MC60_RS14960	COG0583	DNA-binding transcription factor activity
MC60_RS14970	COG1741	Belongs to the pirin family
MC60_RS14975	COG2259	Doxx family
MC60_RS14980	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MC60_RS14985	COG1074	ATP-dependent DNA helicase activity
MC60_RS14990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MC60_RS15000	COG0346	lactoylglutathione lyase activity
MC60_RS15010	COG0004	ammonium transporteR
MC60_RS15015	COG0347	Belongs to the P(II) protein family
MC60_RS15020	COG3706	GGDEF domain
MC60_RS15050	COG1278	Cold shock
MC60_RS15075	COG2197	response regulator
MC60_RS15080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MC60_RS15085	COG3047	cAMP biosynthetic process
MC60_RS15115	COG3135	benzoate transporter
MC60_RS15120	COG1396	sequence-specific DNA binding
MC60_RS15150	COG2926	Belongs to the UPF0265 family
MC60_RS15160	COG3028	Belongs to the UPF0307 family
MC60_RS15165	COG0312	modulator of DNA gyrase
MC60_RS15170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MC60_RS15175	COG5007	Belongs to the BolA IbaG family
MC60_RS15185	COG2854	intermembrane phospholipid transfer
MC60_RS15190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MC60_RS15195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MC60_RS15200	COG1127	ABC transporter
MC60_RS15205	COG0517	IMP dehydrogenase activity
MC60_RS15205	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MC60_RS15210	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MC60_RS15220	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
MC60_RS15225	COG1137	ATPase activity
MC60_RS15230	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MC60_RS15240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MC60_RS15245	COG1660	Displays ATPase and GTPase activities
MC60_RS15250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MC60_RS15270	COG3964	amidohydrolase
MC60_RS15300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MC60_RS15305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MC60_RS15315	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MC60_RS15320	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MC60_RS15325	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MC60_RS15330	COG0723	plastoquinol--plastocyanin reductase activity
MC60_RS15335	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MC60_RS15340	COG2857	Cytochrome c1
MC60_RS15345	COG0625	glutathione transferase activity
MC60_RS15350	COG2969	positive regulation of protein catabolic process
MC60_RS15355	COG2823	Periplasmic or secreted lipoprotein
MC60_RS15360	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MC60_RS15365	COG0792	nuclease activity
MC60_RS15370	COG3107	peptidoglycan biosynthetic process
MC60_RS15375	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MC60_RS15400	COG1987	bacterial-type flagellum assembly
MC60_RS15425	COG1677	Flagellar hook-basal body complex protein FliE
MC60_RS15435	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MC60_RS15465	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
MC60_RS15470	COG1815	bacterial-type flagellum-dependent cell motility
MC60_RS15485	COG1749	Flagellar hook protein flgE
MC60_RS15495	COG4786	Flagellar basal body rod
MC60_RS15500	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MC60_RS15505	COG1706	bacterial-type flagellum-dependent cell motility
MC60_RS15515	COG4786	Flagellar basal body rod
MC60_RS15515	COG1256	bacterial-type flagellum assembly
MC60_RS15520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MC60_RS15535	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MC60_RS15540	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MC60_RS15565	COG1191	sigma factor activity
MC60_RS15570	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MC60_RS15575	COG1360	Flagellar Motor Protein
MC60_RS15585	COG1388	LysM domain
MC60_RS15585	COG0741	lytic transglycosylase activity
MC60_RS15595	COG2001	Belongs to the MraZ family
MC60_RS15600	COG0275	rRNA processing
MC60_RS15605	COG3116	cell division
MC60_RS15610	COG0768	penicillin binding
MC60_RS15615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MC60_RS15620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MC60_RS15625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MC60_RS15630	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MC60_RS15635	COG0772	Belongs to the SEDS family
MC60_RS15640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MC60_RS15645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MC60_RS15650	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MC60_RS15655	COG0849	cell division
MC60_RS15660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MC60_RS15665	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MC60_RS15675	COG0653	protein targeting
MC60_RS15685	COG0494	nUDIX hydrolase
MC60_RS15690	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MC60_RS15695	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
MC60_RS15710	COG1459	type II secretion system
MC60_RS15715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MC60_RS15745	COG2186	Transcriptional regulator
MC60_RS15750	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MC60_RS15755	COG0508	dehydrogenase complex catalyzes the overall conversion of
MC60_RS15760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MC60_RS15770	COG0840	transmembrane signaling receptor activity
MC60_RS15775	COG0840	transmembrane signaling receptor activity
MC60_RS15780	COG1752	Esterase of the alpha-beta hydrolase superfamily
MC60_RS15785	COG1049	propionate catabolic process, 2-methylcitrate cycle
MC60_RS15790	COG2200	EAL domain
MC60_RS15800	COG1280	lysine exporter protein (LysE YggA)
MC60_RS15810	COG0523	cobalamin synthesis protein
MC60_RS15815	COG0477	Major facilitator Superfamily
MC60_RS15830	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MC60_RS15835	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MC60_RS15880	COG5006	permease, DMT superfamily
MC60_RS15885	COG1522	sequence-specific DNA binding
MC60_RS15890	COG0110	maltose O-acetyltransferase activity
MC60_RS15895	COG0366	Alpha amylase catalytic
MC60_RS15900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC60_RS15900	COG1263	PTS System
MC60_RS15920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MC60_RS15925	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MC60_RS15930	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MC60_RS15930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MC60_RS15935	COG2723	6-phospho-beta-galactosidase activity
MC60_RS15940	COG1447	Phosphotransferase system cellobiose-specific component IIA
MC60_RS15945	COG1940	carbohydrate kinase activity
MC60_RS15955	COG1609	Transcriptional regulator
MC60_RS15965	COG0252	asparaginase activity
MC60_RS15980	COG1803	Methylglyoxal synthase
MC60_RS16000	COG1444	tRNA N-acetyltransferase activity
MC60_RS16005	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MC60_RS16005	COG1565	acr, cog1565
MC60_RS16015	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
MC60_RS16045	COG0109	protoheme IX farnesyltransferase activity
MC60_RS16050	COG1012	belongs to the aldehyde dehydrogenase family
MC60_RS16055	COG1177	transmembrane transport
MC60_RS16060	COG1176	ABC-type spermidine putrescine transport system, permease component I
MC60_RS16065	COG3842	ATPase activity
MC60_RS16070	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MC60_RS16075	COG0583	DNA-binding transcription factor activity
MC60_RS16080	COG1757	Na H antiporter
MC60_RS16120	COG0297	glycogen (starch) synthase activity
MC60_RS16125	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MC60_RS16130	COG2813	Specifically methylates the guanine in position
MC60_RS16135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MC60_RS16140	COG5001	Diguanylate cyclase
MC60_RS16140	COG3706	GGDEF domain
MC60_RS16140	COG2203	Gaf domain
MC60_RS16140	COG4251	negative regulation of phosphorylation
MC60_RS16145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MC60_RS16155	COG2995	paraquat-inducible protein a
MC60_RS16160	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MC60_RS16160	COG3008	intermembrane lipid transfer
MC60_RS16165	COG3009	Protein conserved in bacteria
MC60_RS16175	COG3240	lipase activity
MC60_RS16190	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
MC60_RS16195	COG1194	a g-specific adenine glycosylase
MC60_RS16205	COG3409	Peptidoglycan-binding domain 1 protein
MC60_RS16205	COG3267	Type II secretory pathway component ExeA
MC60_RS16210	COG0617	tRNA 3'-terminal CCA addition
MC60_RS16215	COG0306	phosphate transporter
MC60_RS16220	COG1392	Phosphate transport regulator
MC60_RS16225	COG3025	triphosphatase activity
MC60_RS16230	COG3133	Outer membrane lipoprotein
MC60_RS16235	COG0456	acetyltransferase
MC60_RS16250	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MC60_RS16255	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MC60_RS16265	COG3031	protein transport across the cell outer membrane
MC60_RS16275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MC60_RS16280	COG1459	type II secretion system
MC60_RS16285	COG2165	general secretion pathway protein
MC60_RS16295	COG2165	general secretion pathway protein
MC60_RS16300	COG4795	General secretion pathway protein
MC60_RS16310	COG3156	type II secretion system protein K
MC60_RS16320	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
MC60_RS16335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MC60_RS16345	COG1902	pentaerythritol trinitrate reductase activity
MC60_RS16350	COG1011	Hydrolase
MC60_RS16355	COG0494	nUDIX hydrolase
MC60_RS16360	COG1218	3'(2'),5'-bisphosphate nucleotidase
MC60_RS16365	COG0814	amino acid
MC60_RS16370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MC60_RS16385	COG0626	cystathionine gamma-synthase activity
MC60_RS16390	COG0460	homoserine dehydrogenase
MC60_RS16390	COG0527	aspartate kinase activity
MC60_RS16395	COG1346	cytolysis
MC60_RS16400	COG1380	Effector of murein hydrolase LrgA
MC60_RS16405	COG0583	DNA-binding transcription factor activity
MC60_RS16440	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MC60_RS16450	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MC60_RS16460	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MC60_RS16465	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MC60_RS16475	COG0137	argininosuccinate synthase activity
MC60_RS16480	COG0165	Argininosuccinate lyase
MC60_RS16485	COG0583	DNA-binding transcription factor activity
MC60_RS16510	COG0110	maltose O-acetyltransferase activity
MC60_RS16515	COG3174	membrane
MC60_RS16520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC60_RS16525	COG1126	abc transporter atp-binding protein
MC60_RS16530	COG0765	amino acid transport
MC60_RS16535	COG0765	amino acid transport
MC60_RS16540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MC60_RS16545	COG1505	serine-type exopeptidase activity
MC60_RS16560	COG1028	Short-chain dehydrogenase reductase Sdr
MC60_RS16565	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MC60_RS16580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MC60_RS16585	COG4991	sh3 domain protein
MC60_RS16590	COG2816	NAD+ diphosphatase activity
MC60_RS16595	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MC60_RS16600	COG1940	carbohydrate kinase activity
MC60_RS16605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MC60_RS16610	COG0126	phosphoglycerate kinase activity
MC60_RS16620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MC60_RS16650	COG0583	DNA-binding transcription factor activity
MC60_RS16660	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MC60_RS16670	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MC60_RS16675	COG1595	DNA-templated transcription, initiation
MC60_RS16695	COG0481	GTPase activity
MC60_RS16700	COG0681	Belongs to the peptidase S26 family
MC60_RS16705	COG0571	ribonuclease III activity
MC60_RS16715	COG1381	Involved in DNA repair and RecF pathway recombination
MC60_RS16720	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MC60_RS16725	COG3023	N-Acetylmuramoyl-L-alanine amidase
MC60_RS16730	COG4807	Protein conserved in bacteria
MC60_RS16740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MC60_RS16745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MC60_RS16750	COG3956	TIGRFAM MazG family protein
MC60_RS16755	COG0504	CTP synthase activity
MC60_RS16760	COG0148	phosphopyruvate hydratase activity
MC60_RS16765	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MC60_RS16770	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MC60_RS16780	COG0585	pseudouridine synthase activity
MC60_RS16785	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MC60_RS16790	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MC60_RS16795	COG1238	metal cluster binding
MC60_RS16800	COG1388	LysM domain
MC60_RS16800	COG4942	peptidase
MC60_RS16810	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MC60_RS16815	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MC60_RS16820	COG1610	YqeY-like protein
MC60_RS16825	COG0358	DNA primase activity
MC60_RS16830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MC60_RS16930	COG0138	bifunctional purine biosynthesis protein purh
MC60_RS16945	COG3036	rescue of stalled ribosome
MC60_RS16950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MC60_RS16955	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MC60_RS16965	COG0673	inositol 2-dehydrogenase activity
MC60_RS16975	COG1585	Membrane protein implicated in regulation of membrane protease activity
MC60_RS16980	COG0330	HflC and HflK could
MC60_RS16985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MC60_RS16985	COG1648	precorrin-2 dehydrogenase activity
MC60_RS16990	COG0175	sulfate reduction
MC60_RS16995	COG2895	sulfate adenylyltransferase (ATP) activity
MC60_RS17000	COG0471	metal ion transport
MC60_RS17000	COG3273	potassium ion transport
MC60_RS17005	COG0529	Catalyzes the synthesis of activated sulfate
MC60_RS17025	COG0840	transmembrane signaling receptor activity
MC60_RS17045	COG1136	(ABC) transporter
MC60_RS17060	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
MC60_RS17075	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MC60_RS17080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MC60_RS17085	COG0163	prenyltransferase activity
MC60_RS17100	COG1131	(ABC) transporter
MC60_RS17105	COG0842	Transport permease protein
MC60_RS17115	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MC60_RS17120	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MC60_RS17125	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MC60_RS17135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MC60_RS17140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MC60_RS17145	COG1489	DNA binding
MC60_RS17155	COG1643	Atp-dependent helicase
MC60_RS17160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MC60_RS17165	COG0346	lactoylglutathione lyase activity
MC60_RS17175	COG2076	Multidrug Resistance protein
MC60_RS17180	COG0583	DNA-binding transcription factor activity
MC60_RS17190	COG0671	phosphoesterase, PA-phosphatase related
MC60_RS17205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MC60_RS17210	COG0038	chloride channel
MC60_RS17220	COG0316	Belongs to the HesB IscA family
MC60_RS17245	COG1280	lysine exporter protein (LysE YggA)
MC60_RS17250	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MC60_RS17265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MC60_RS17295	COG0745	RESPONSE REGULATOR receiver
MC60_RS17300	COG3104	oligopeptide transport
MC60_RS17305	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MC60_RS17310	COG1555	photosystem II stabilization
MC60_RS17320	COG2350	Protein conserved in bacteria
MC60_RS17325	COG2917	probably involved in intracellular septation
MC60_RS17330	COG0076	glutamate decarboxylase activity
MC60_RS17335	COG1272	protein, Hemolysin III
MC60_RS17340	COG2985	domain, Protein
MC60_RS17340	COG0569	domain protein
MC60_RS17370	COG0477	Major facilitator Superfamily
MC60_RS17375	COG0583	DNA-binding transcription factor activity
MC60_RS17380	COG3227	Zinc metalloprotease (Elastase)
MC60_RS17385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC60_RS17390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC60_RS17400	COG2731	YhcH YjgK YiaL family protein
MC60_RS17410	COG0668	transmembrane transport
MC60_RS17420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MC60_RS17430	COG0789	Transcriptional regulator
MC60_RS17435	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
MC60_RS17455	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MC60_RS17465	COG0488	(ABC) transporter
MC60_RS17470	COG0517	IMP dehydrogenase activity
MC60_RS17470	COG0516	GMP reductase activity
MC60_RS17480	COG0784	Response regulator, receiver
MC60_RS17480	COG0835	chemotaxis
MC60_RS17485	COG2755	lipolytic protein G-D-S-L family
MC60_RS17490	COG4181	ATPase activity
MC60_RS17495	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
MC60_RS17500	COG1090	epimerase
MC60_RS17505	COG2200	EAL domain
MC60_RS17510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC60_RS17515	COG4935	Belongs to the peptidase S8 family
MC60_RS17515	COG2234	aminopeptidase activity
MC60_RS17520	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MC60_RS17525	COG3171	Protein conserved in bacteria
MC60_RS17530	COG2066	Belongs to the glutaminase family
MC60_RS17535	COG2897	thiosulfate sulfurtransferase activity
MC60_RS17540	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MC60_RS17575	COG1132	(ABC) transporter
MC60_RS17600	COG0582	viral genome integration into host DNA
MC60_RS17620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MC60_RS17640	COG4974	Belongs to the 'phage' integrase family
MC60_RS17685	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
MC60_RS17690	COG5001	Diguanylate cyclase
MC60_RS17690	COG3300	MHYT domain
MC60_RS17710	COG4628	conserved protein (DUF2132)
MC60_RS17715	COG0688	phosphatidylethanolamine metabolic process
MC60_RS17720	COG1162	GTPase activity
MC60_RS17725	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MC60_RS17765	COG1278	Cold shock
MC60_RS17775	COG0840	transmembrane signaling receptor activity
MC60_RS17780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MC60_RS17785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MC60_RS17790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MC60_RS17840	COG0848	biopolymer transport protein
MC60_RS17845	COG0811	peptide transport
MC60_RS17850	COG0811	peptide transport
MC60_RS17860	COG4206	TonB-dependent receptor
MC60_RS17865	COG4174	ABC transporter (Permease)
MC60_RS17870	COG4239	(ABC) transporter, permease
MC60_RS17880	COG0444	Belongs to the ABC transporter superfamily
MC60_RS17885	COG4608	Belongs to the ABC transporter superfamily
MC60_RS17895	COG2195	Cleaves the N-terminal amino acid of tripeptides
MC60_RS17905	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MC60_RS17910	COG1073	alpha beta
MC60_RS17925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MC60_RS17950	COG0243	molybdopterin cofactor binding
MC60_RS17955	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MC60_RS17955	COG1648	precorrin-2 dehydrogenase activity
MC60_RS17965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MC60_RS17965	COG1116	anion transmembrane transporter activity
MC60_RS17970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MC60_RS17975	COG1116	anion transmembrane transporter activity
MC60_RS17980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MC60_RS17980	COG2146	nitrite reductase [NAD(P)H] activity
MC60_RS17985	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MC60_RS17985	COG2146	nitrite reductase [NAD(P)H] activity
MC60_RS17990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MC60_RS17995	COG2313	pseudouridylate synthase activity
MC60_RS18015	COG0521	Mo-molybdopterin cofactor biosynthetic process
MC60_RS18025	COG2966	Psort location CytoplasmicMembrane, score
MC60_RS18030	COG3610	response to peptide
MC60_RS18040	COG4175	Glycine betaine
MC60_RS18045	COG4176	ABC-type proline glycine betaine transport system permease component
MC60_RS18050	COG2113	Glycine betaine
MC60_RS18055	COG0175	sulfate reduction
MC60_RS18060	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MC60_RS18065	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MC60_RS18070	COG0384	phenazine biosynthesis protein PhzF
MC60_RS18075	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MC60_RS18090	COG0786	glutamate:sodium symporter activity
MC60_RS18095	COG0252	asparaginase activity
MC60_RS18100	COG3139	Protein of unknown function (DUF1315)
MC60_RS18120	COG0616	signal peptide processing
MC60_RS18125	COG1902	pentaerythritol trinitrate reductase activity
MC60_RS18125	COG0446	pyridine nucleotide-disulphide oxidoreductase
MC60_RS18130	COG0778	Nitroreductase
MC60_RS18140	COG0110	maltose O-acetyltransferase activity
MC60_RS18145	COG2264	protein methyltransferase activity
MC60_RS18150	COG0604	alcohol dehydrogenase
MC60_RS18155	COG0583	DNA-binding transcription factor activity
MC60_RS18160	COG2190	(PTS) system
MC60_RS18160	COG1263	PTS System
MC60_RS18160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC60_RS18165	COG4145	pantothenate transmembrane transporter activity
MC60_RS18170	COG3924	membrane
MC60_RS18175	COG0439	Biotin carboxylase
MC60_RS18180	COG0511	ligase activity, forming carbon-carbon bonds
MC60_RS18185	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MC60_RS18190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MC60_RS18205	COG3381	protein complex oligomerization
MC60_RS18220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MC60_RS18230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MC60_RS18235	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MC60_RS18235	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MC60_RS18250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MC60_RS18255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MC60_RS18260	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MC60_RS18265	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MC60_RS18270	COG4172	Belongs to the ABC transporter superfamily
MC60_RS18280	COG0601	transmembrane transport
MC60_RS18285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MC60_RS18290	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MC60_RS18295	COG0142	geranyltranstransferase activity
MC60_RS18300	COG1722	exodeoxyribonuclease VII activity
MC60_RS18305	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MC60_RS18310	COG1360	Flagellar Motor Protein
MC60_RS18325	COG1534	Rna-binding protein
MC60_RS18330	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MC60_RS18340	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MC60_RS18345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MC60_RS18350	COG0149	triose-phosphate isomerase activity
MC60_RS18355	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MC60_RS18370	COG0779	Required for maturation of 30S ribosomal subunits
MC60_RS18375	COG0195	Participates in both transcription termination and antitermination
MC60_RS18380	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MC60_RS18385	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MC60_RS18390	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MC60_RS18395	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MC60_RS18400	COG1185	polyribonucleotide nucleotidyltransferase activity
MC60_RS18405	COG2211	Major facilitator Superfamily
MC60_RS18410	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
MC60_RS18415	COG1422	Protein of unknown function (DUF1090)
MC60_RS18420	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MC60_RS18425	COG0826	peptidase U32
MC60_RS18440	COG0312	modulator of DNA gyrase
MC60_RS18445	COG0312	modulator of DNA gyrase
MC60_RS18455	COG4974	Belongs to the 'phage' integrase family
MC60_RS18460	COG1970	mechanosensitive ion channel activity
MC60_RS18490	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MC60_RS18525	COG0326	Molecular chaperone. Has ATPase activity
MC60_RS18545	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MC60_RS18550	COG0321	lipoyl(octanoyl) transferase activity
MC60_RS18555	COG2921	Belongs to the UPF0250 family
MC60_RS18560	COG1686	Belongs to the peptidase S11 family
MC60_RS18565	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MC60_RS18570	COG2951	lytic endotransglycosylase activity
MC60_RS18575	COG0772	Belongs to the SEDS family
MC60_RS18580	COG0768	penicillin binding
MC60_RS18585	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MC60_RS18590	COG0799	negative regulation of ribosome biogenesis
MC60_RS18595	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MC60_RS18610	COG0495	leucyl-tRNA aminoacylation
MC60_RS18615	COG2888	peptidyl-tyrosine sulfation
MC60_RS18620	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MC60_RS18625	COG4535	Mg2 and Co2 transporter CorC
MC60_RS18630	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MC60_RS18635	COG1702	phosphate starvation-inducible protein PhoH
MC60_RS18640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MC60_RS18645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MC60_RS18650	COG1335	isochorismatase
MC60_RS18665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MC60_RS18670	COG2199	diguanylate cyclase activity
MC60_RS18680	COG2199	diguanylate cyclase activity
MC60_RS18690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MC60_RS18710	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MC60_RS18715	COG2011	ABC-type metal ion transport system permease component
MC60_RS18720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MC60_RS18730	COG0516	GMP reductase activity
MC60_RS18735	COG4067	protein conserved in archaea
MC60_RS18735	COG0189	ligase activity
MC60_RS18755	COG0300	oxidoreductase activity
MC60_RS18775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MC60_RS18780	COG3214	Protein conserved in bacteria
MC60_RS18795	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
MC60_RS18800	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
MC60_RS18805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MC60_RS18810	COG1053	succinate dehydrogenase
MC60_RS18820	COG0584	glycerophosphoryl diester phosphodiesterase
MC60_RS18825	COG3264	Mechanosensitive ion channel
MC60_RS18825	COG1511	domain protein
MC60_RS18835	COG0739	heme binding
MC60_RS18850	COG0583	DNA-binding transcription factor activity
MC60_RS18865	COG0583	DNA-binding transcription factor activity
MC60_RS18870	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MC60_RS18900	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MC60_RS18905	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MC60_RS18915	COG0338	D12 class N6 adenine-specific DNA methyltransferase
MC60_RS18920	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MC60_RS18925	COG0546	phosphoglycolate phosphatase activity
MC60_RS18930	COG0180	Tryptophanyl-tRNA synthetase
MC60_RS18945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MC60_RS18955	COG1012	belongs to the aldehyde dehydrogenase family
MC60_RS18970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MC60_RS18985	COG0657	acetylesterase activity
MC60_RS18995	COG0471	metal ion transport
MC60_RS18995	COG0490	domain, Protein
MC60_RS19040	COG0012	GTP binding
MC60_RS19045	COG0193	aminoacyl-tRNA hydrolase activity
MC60_RS19050	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MC60_RS19060	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MC60_RS19065	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
MC60_RS19070	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MC60_RS19075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MC60_RS19080	COG2890	protein-(glutamine-N5) methyltransferase activity
MC60_RS19090	COG2912	Transglutaminase-like superfamily
MC60_RS19095	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MC60_RS19100	COG1301	dicarboxylic acid transport
MC60_RS19110	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MC60_RS19125	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MC60_RS19130	COG1115	amino acid carrier protein
MC60_RS19145	COG0583	DNA-binding transcription factor activity
MC60_RS19150	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MC60_RS19160	COG0189	ligase activity
MC60_RS19165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MC60_RS19175	COG3091	SprT-like family
MC60_RS19185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MC60_RS19195	COG0251	oxidation-reduction process
MC60_RS19210	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MC60_RS19215	COG0739	heme binding
MC60_RS19220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MC60_RS19225	COG3408	Glycogen debranching enzyme
MC60_RS19225	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
MC60_RS19235	COG1881	PFAM PEBP family protein
MC60_RS19240	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MC60_RS19245	COG0583	DNA-binding transcription factor activity
MC60_RS19255	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MC60_RS19265	COG0583	DNA-binding transcription factor activity
MC60_RS19270	COG1028	Short-chain dehydrogenase reductase Sdr
MC60_RS19275	COG0616	signal peptide processing
MC60_RS19280	COG3724	N-succinylarginine dihydrolase activity
MC60_RS19295	COG0840	transmembrane signaling receptor activity
MC60_RS19305	COG2971	BadF BadG BcrA BcrD
MC60_RS19315	COG4608	Belongs to the ABC transporter superfamily
MC60_RS19320	COG0444	Belongs to the ABC transporter superfamily
MC60_RS19325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MC60_RS19340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MC60_RS19350	COG0640	Transcriptional regulator
MC60_RS19355	COG0798	PFAM Bile acid sodium symporter
MC60_RS19360	COG1393	Belongs to the ArsC family
MC60_RS19375	COG1677	Flagellar hook-basal body complex protein FliE
MC60_RS19385	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MC60_RS19440	COG1684	flagellar biosynthetic protein fliR
MC60_RS19450	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MC60_RS19475	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
MC60_RS19480	COG2198	Histidine kinase
MC60_RS19480	COG0784	Response regulator, receiver
MC60_RS19480	COG0643	Histidine kinase
MC60_RS19485	COG2201	protein-glutamate methylesterase activity
MC60_RS19490	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MC60_RS19495	COG1360	Flagellar Motor Protein
MC60_RS19500	COG1192	Involved in chromosome partitioning
MC60_RS19510	COG0835	chemotaxis
MC60_RS19525	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MC60_RS19530	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MC60_RS19535	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MC60_RS19540	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MC60_RS19545	COG1138	Cytochrome C-type biogenesis protein
MC60_RS19550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MC60_RS19575	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MC60_RS19580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MC60_RS19580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MC60_RS19595	COG0259	pyridoxamine-phosphate oxidase activity
MC60_RS19625	COG3153	acetyltransferase
MC60_RS19645	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MC60_RS19650	COG2867	negative regulation of translational initiation
MC60_RS19655	COG2914	Belongs to the UPF0125 (RnfH) family
MC60_RS19660	COG0702	epimerase
MC60_RS19665	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MC60_RS19670	COG1454	alcohol dehydrogenase
MC60_RS19680	COG0564	pseudouridine synthase activity
MC60_RS19685	COG1957	nucleoside hydrolase
MC60_RS19710	COG1280	lysine exporter protein (LysE YggA)
MC60_RS19720	COG3263	regulation of cellular component size
MC60_RS19730	COG1876	peptidase activity
MC60_RS19735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MC60_RS19740	COG1393	Belongs to the ArsC family
MC60_RS19750	COG3069	C4-dicarboxylate transmembrane transporter activity
MC60_RS19755	COG1473	amidohydrolase
MC60_RS19765	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MC60_RS19770	COG0017	Asparaginyl-tRNA synthetase
MC60_RS19790	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MC60_RS19795	COG0156	8-amino-7-oxononanoate synthase activity
MC60_RS19800	COG1073	alpha beta
MC60_RS19800	COG2226	methyltransferase
MC60_RS19805	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MC60_RS19810	COG0501	Belongs to the peptidase M48B family
MC60_RS19815	COG0633	Ferredoxin
MC60_RS19815	COG3217	Mosc domain protein beta barrel domain protein
MC60_RS19815	COG3217	Mosc domain protein beta barrel domain protein
MC60_RS19815	COG0633	Ferredoxin
MC60_RS19825	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MC60_RS19825	COG0674	pyruvate-flavodoxin oxidoreductase activity
MC60_RS19825	COG1013	pyruvate-flavodoxin oxidoreductase activity
MC60_RS19825	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MC60_RS19830	COG2841	Protein conserved in bacteria
MC60_RS19840	COG0534	Mate efflux family protein
MC60_RS19875	COG1309	transcriptional regulator
MC60_RS19890	COG0791	NLP P60 protein
MC60_RS19895	COG0583	DNA-binding transcription factor activity
MC60_RS19915	COG0500	methyltransferase
MC60_RS19920	COG4106	trans-aconitate 2-methyltransferase activity
MC60_RS19925	COG1801	Protein of unknown function DUF72
MC60_RS19935	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MC60_RS19940	COG0217	transcriptional regulatory protein
MC60_RS19945	COG2194	sulfuric ester hydrolase activity
MC60_RS19950	COG1940	carbohydrate kinase activity
MC60_RS19950	COG1846	Transcriptional regulator
MC60_RS19955	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MC60_RS19960	COG0363	glucosamine-6-phosphate deaminase activity
MC60_RS19965	COG1263	PTS System
MC60_RS19965	COG2190	(PTS) system
MC60_RS19965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC60_RS19975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MC60_RS19980	COG0735	belongs to the Fur family
MC60_RS19990	COG0716	FMN binding
MC60_RS20005	COG0596	Alpha beta hydrolase
MC60_RS20010	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
MC60_RS20015	COG0033	Phosphoglucomutase
MC60_RS20025	COG1846	Transcriptional regulator
MC60_RS20030	COG2951	lytic endotransglycosylase activity
MC60_RS20035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MC60_RS20040	COG4136	ATPase activity
MC60_RS20050	COG4134	Bacterial extracellular solute-binding protein
MC60_RS20055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MC60_RS20060	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MC60_RS20070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MC60_RS20080	COG0729	surface antigen
MC60_RS20105	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MC60_RS20115	COG0741	lytic transglycosylase activity
MC60_RS20130	COG1607	acyl-coa hydrolase
MC60_RS20145	COG0741	lytic transglycosylase activity
MC60_RS20145	COG1388	LysM domain
MC60_RS20150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC60_RS20155	COG2226	methyltransferase
MC60_RS20160	COG0328	RNA-DNA hybrid ribonuclease activity
MC60_RS20165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MC60_RS20175	COG0784	Response regulator, receiver
MC60_RS20175	COG3437	response regulator, receiver
MC60_RS20180	COG1960	acyl-CoA dehydrogenase activity
MC60_RS20185	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MC60_RS20190	COG0121	glutamine amidotransferase
MC60_RS20200	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MC60_RS20225	COG2197	response regulator
MC60_RS20230	COG3850	Histidine kinase
MC60_RS20235	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MC60_RS20240	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MC60_RS20240	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
MC60_RS20250	COG0243	molybdopterin cofactor binding
MC60_RS20255	COG0437	4 iron, 4 sulfur cluster binding
MC60_RS20260	COG0348	domain, Protein
MC60_RS20270	COG3005	denitrification pathway
MC60_RS20275	COG0521	Mo-molybdopterin cofactor biosynthetic process
MC60_RS20280	COG0315	cyclic pyranopterin monophosphate synthase activity
MC60_RS20285	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MC60_RS20290	COG0314	molybdopterin synthase activity
MC60_RS20305	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MC60_RS20310	COG2267	carboxylic ester hydrolase activity
MC60_RS20325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MC60_RS20335	COG0302	gtp cyclohydrolase
MC60_RS20340	COG0840	transmembrane signaling receptor activity
MC60_RS20355	COG0583	DNA-binding transcription factor activity
MC60_RS20370	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MC60_RS20385	COG2195	Cleaves the N-terminal amino acid of tripeptides
MC60_RS20395	COG1166	arginine decarboxylase activity
MC60_RS20420	COG2801	Transposase and inactivated derivatives
MC60_RS20435	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MC60_RS20440	COG1187	pseudouridine synthase activity
MC60_RS20445	COG2807	transmembrane transport
MC60_RS20455	COG0583	DNA-binding transcription factor activity
MC60_RS20475	COG2979	Protein of unknown function (DUF533)
MC60_RS20485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC60_RS20490	COG1271	oxidase subunit
MC60_RS20495	COG1294	oxidase, subunit
MC60_RS20505	COG2814	Major facilitator Superfamily
MC60_RS20515	COG0656	L-ascorbic acid biosynthetic process
MC60_RS20535	COG0583	DNA-binding transcription factor activity
MC60_RS20540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MC60_RS20545	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MC60_RS20550	COG2271	Major facilitator Superfamily
MC60_RS20555	COG1349	DNA-binding transcription factor activity
MC60_RS20570	COG0584	glycerophosphoryl diester phosphodiesterase
MC60_RS20575	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MC60_RS20580	COG1605	Chorismate mutase
MC60_RS20580	COG0287	Prephenate dehydrogenase
MC60_RS20590	COG3085	chromosome segregation
MC60_RS20595	COG4574	serine-type endopeptidase inhibitor activity
MC60_RS20615	COG1770	oligopeptidase
MC60_RS20620	COG4771	TonB-dependent receptor
MC60_RS20625	COG3083	sulfuric ester hydrolase activity
MC60_RS20630	COG3082	Protein of unknown function (DUF1414)
MC60_RS20635	COG3081	Nucleoid-associated protein
MC60_RS20645	COG1175	transmembrane transport
MC60_RS20650	COG3833	ABC-type maltose transport systems, permease component
MC60_RS20655	COG3842	ATPase activity
MC60_RS20680	COG0425	Belongs to the sulfur carrier protein TusA family
MC60_RS20685	COG4783	chaperone-mediated protein folding
MC60_RS20695	COG1393	Belongs to the ArsC family
MC60_RS20720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC60_RS20725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MC60_RS20730	COG2431	L-lysine efflux transmembrane transporter activity
MC60_RS20740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC60_RS20750	COG4160	amino acid transport
MC60_RS20760	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MC60_RS20770	COG0446	pyridine nucleotide-disulphide oxidoreductase
MC60_RS20795	COG0628	permease