locus-tag	class	description
JN439_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JN439_RS00010	COG0592	DNA-directed DNA polymerase activity
JN439_RS00020	COG0187	DNA topoisomerase II activity
JN439_RS00025	COG2207	Transcriptional regulator
JN439_RS00030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JN439_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
JN439_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
JN439_RS00045	COG3977	Valine--pyruvate aminotransferase
JN439_RS00060	COG2814	Major facilitator Superfamily
JN439_RS00065	COG0745	RESPONSE REGULATOR receiver
JN439_RS00070	COG2205	protein histidine kinase activity
JN439_RS00090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JN439_RS00095	COG4191	Histidine kinase
JN439_RS00095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JN439_RS00100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JN439_RS00105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JN439_RS00110	COG1309	transcriptional regulator
JN439_RS00140	COG0561	phosphatase activity
JN439_RS00145	COG2267	carboxylic ester hydrolase activity
JN439_RS00150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JN439_RS00155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JN439_RS00160	COG1758	RNA polymerase activity
JN439_RS00170	COG0859	PFAM glycosyl transferase family 9
JN439_RS00175	COG3642	lipopolysaccharide core region biosynthetic process
JN439_RS00220	COG0589	response to stress
JN439_RS00225	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JN439_RS00230	COG3706	GGDEF domain
JN439_RS00235	COG1528	Iron-storage protein
JN439_RS00240	COG2081	HI0933 family
JN439_RS00245	COG2223	nitrite transmembrane transporter activity
JN439_RS00250	COG1280	lysine exporter protein (LysE YggA)
JN439_RS00265	COG3188	usher protein
JN439_RS00285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JN439_RS00285	COG2205	protein histidine kinase activity
JN439_RS00295	COG3275	phosphorelay sensor kinase activity
JN439_RS00300	COG3279	Response regulator of the LytR AlgR family
JN439_RS00305	COG2223	nitrite transmembrane transporter activity
JN439_RS00310	COG3385	transposase activity
JN439_RS00315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JN439_RS00320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JN439_RS00370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JN439_RS00375	COG2166	iron-sulfur cluster assembly
JN439_RS00380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JN439_RS00400	COG1063	alcohol dehydrogenase
JN439_RS00415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JN439_RS00460	COG1609	Transcriptional regulator
JN439_RS00475	COG1580	Controls the rotational direction of flagella during chemotaxis
JN439_RS00480	COG3161	chorismate lyase activity
JN439_RS00485	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JN439_RS00490	COG2937	Belongs to the GPAT DAPAT family
JN439_RS00495	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JN439_RS00510	COG0534	Mate efflux family protein
JN439_RS00515	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JN439_RS00520	COG2205	protein histidine kinase activity
JN439_RS00525	COG0745	RESPONSE REGULATOR receiver
JN439_RS00535	COG1045	serine acetyltransferase
JN439_RS00545	COG3074	FtsZ-dependent cytokinesis
JN439_RS00550	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
JN439_RS00555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JN439_RS00555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JN439_RS00560	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JN439_RS00595	COG1609	Transcriptional regulator
JN439_RS00600	COG3250	beta-galactosidase activity
JN439_RS00605	COG2731	YhcH YjgK YiaL family protein
JN439_RS00610	COG0531	amino acid
JN439_RS00615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JN439_RS00620	COG0531	amino acid
JN439_RS00625	COG0385	Bile acid
JN439_RS00630	COG1262	PFAM Formylglycine-generating sulfatase enzyme
JN439_RS00655	COG0583	DNA-binding transcription factor activity
JN439_RS00660	COG1079	Belongs to the binding-protein-dependent transport system permease family
JN439_RS00665	COG4603	Belongs to the binding-protein-dependent transport system permease family
JN439_RS00670	COG3845	ABC transporter
JN439_RS00675	COG1744	ABC transporter substrate-binding protein PnrA-like
JN439_RS00690	COG0210	DNA helicase
JN439_RS00705	COG1943	Transposase
JN439_RS00710	COG0583	DNA-binding transcription factor activity
JN439_RS00755	COG1280	lysine exporter protein (LysE YggA)
JN439_RS00765	COG2962	Rard protein
JN439_RS00775	COG1012	belongs to the aldehyde dehydrogenase family
JN439_RS00780	COG1396	sequence-specific DNA binding
JN439_RS00785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JN439_RS00795	COG0519	Catalyzes the synthesis of GMP from XMP
JN439_RS00795	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JN439_RS00805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JN439_RS00825	COG1322	Protein conserved in bacteria
JN439_RS00830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JN439_RS00835	COG0569	domain protein
JN439_RS00840	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JN439_RS00840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JN439_RS00845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JN439_RS00850	COG0242	peptide deformylase activity
JN439_RS00860	COG0758	DNA mediated transformation
JN439_RS00865	COG2922	Belongs to the Smg family
JN439_RS00870	COG0551	DNA topoisomerase type I activity
JN439_RS00875	COG0009	L-threonylcarbamoyladenylate synthase
JN439_RS00880	COG0408	coproporphyrinogen oxidase activity
JN439_RS00885	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JN439_RS00890	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JN439_RS00905	COG3078	GTPase activator activity
JN439_RS00915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JN439_RS00925	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JN439_RS00935	COG3852	Histidine kinase
JN439_RS00945	COG0174	glutamine synthetase
JN439_RS00950	COG1217	gtp-binding protein TYPA
JN439_RS00960	COG1295	ribonuclease BN
JN439_RS00965	COG1490	D-aminoacyl-tRNA deacylase activity
JN439_RS00975	COG0456	acetyltransferase
JN439_RS00985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JN439_RS00990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JN439_RS00995	COG2610	gluconate transmembrane transporter activity
JN439_RS01000	COG3265	gluconokinase activity
JN439_RS01005	COG0129	dihydroxy-acid dehydratase activity
JN439_RS01010	COG0800	Aldolase
JN439_RS01025	COG1609	Transcriptional regulator
JN439_RS01035	COG4942	peptidase
JN439_RS01040	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JN439_RS01045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JN439_RS01050	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
JN439_RS01055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JN439_RS01060	COG0316	Belongs to the HesB IscA family
JN439_RS01060	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JN439_RS01065	COG1040	competence protein
JN439_RS01070	COG0596	Alpha beta hydrolase
JN439_RS01085	COG2183	response to ionizing radiation
JN439_RS01090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JN439_RS01100	COG2205	protein histidine kinase activity
JN439_RS01110	COG0051	transcription antitermination factor activity, RNA binding
JN439_RS01115	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JN439_RS01120	COG0088	Forms part of the polypeptide exit tunnel
JN439_RS01125	COG0089	rRNA binding
JN439_RS01130	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JN439_RS01135	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JN439_RS01140	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JN439_RS01145	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JN439_RS01150	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JN439_RS01155	COG0255	Belongs to the universal ribosomal protein uL29 family
JN439_RS01160	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JN439_RS01165	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JN439_RS01170	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JN439_RS01175	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JN439_RS01180	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JN439_RS01185	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JN439_RS01190	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JN439_RS01195	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JN439_RS01200	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JN439_RS01205	COG1841	ribosomal large subunit assembly
JN439_RS01210	COG0200	Binds to the 23S rRNA
JN439_RS01215	COG0201	protein transport
JN439_RS01220	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JN439_RS01225	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JN439_RS01230	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JN439_RS01235	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JN439_RS01240	COG0202	RNA polymerase activity
JN439_RS01245	COG0203	ribosomal protein L17
JN439_RS01295	COG1484	DNA-dependent DNA replication
JN439_RS01300	COG4584	PFAM Integrase catalytic
JN439_RS01310	COG4584	PFAM Integrase catalytic
JN439_RS01335	COG2249	NAD(P)H dehydrogenase (quinone) activity
JN439_RS01340	COG0583	DNA-binding transcription factor activity
JN439_RS01350	COG0675	Transposase, IS605 OrfB family
JN439_RS01355	COG4221	oxidoreductase activity
JN439_RS01370	COG1770	oligopeptidase
JN439_RS01375	COG2358	TRAP transporter, solute receptor (TAXI family
JN439_RS01390	COG3714	YhhN family
JN439_RS01405	COG0583	DNA-binding transcription factor activity
JN439_RS01420	COG1301	dicarboxylic acid transport
JN439_RS01430	COG2095	MarC family integral membrane protein
JN439_RS01440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JN439_RS01450	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
JN439_RS01460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JN439_RS01490	COG0742	ribosomal rna small subunit methyltransferase
JN439_RS01495	COG0552	protein localization to endoplasmic reticulum
JN439_RS01500	COG2884	Cell division ATP-binding protein ftsE
JN439_RS01505	COG2177	Part of the ABC transporter FtsEX involved in
JN439_RS01515	COG0288	reversible hydration of carbon dioxide
JN439_RS01520	COG2188	Transcriptional regulator
JN439_RS01525	COG1228	amidohydrolase
JN439_RS01530	COG0010	Belongs to the arginase family
JN439_RS01535	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JN439_RS01540	COG2986	histidine ammonia-lyase
JN439_RS01545	COG0387	Pfam Sodium calcium exchanger
JN439_RS01550	COG2200	EAL domain
JN439_RS01605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JN439_RS01610	COG1459	type II secretion system
JN439_RS01625	COG2165	general secretion pathway protein
JN439_RS01655	COG1077	Cell shape determining protein MreB Mrl
JN439_RS01660	COG1792	Involved in formation and maintenance of cell shape
JN439_RS01665	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
JN439_RS01670	COG0424	maF-like protein
JN439_RS01675	COG1530	ribonuclease E activity
JN439_RS01680	COG3164	Protein of unknown function
JN439_RS01685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JN439_RS01690	COG0312	modulator of DNA gyrase
JN439_RS01705	COG0477	Major facilitator Superfamily
JN439_RS01715	COG2321	neutral zinc metallopeptidase
JN439_RS01725	COG0675	Transposase, IS605 OrfB family
JN439_RS01760	COG0189	ligase activity
JN439_RS01765	COG0642	Histidine kinase
JN439_RS01770	COG0745	RESPONSE REGULATOR receiver
JN439_RS01785	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JN439_RS01790	COG0352	thiamine-phosphate diphosphorylase activity
JN439_RS01795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JN439_RS01805	COG2022	thiamine diphosphate biosynthetic process
JN439_RS01810	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JN439_RS01825	COG3932	Exopolysaccharide synthesis, ExoD
JN439_RS01840	COG1733	regulation of RNA biosynthetic process
JN439_RS01845	COG0456	acetyltransferase
JN439_RS01875	COG2226	methyltransferase
JN439_RS01885	COG1494	fructose-1,6-bisphosphatase
JN439_RS01895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JN439_RS01900	COG5007	Belongs to the BolA IbaG family
JN439_RS01910	COG2854	intermembrane phospholipid transfer
JN439_RS01915	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JN439_RS01920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JN439_RS01925	COG1127	ABC transporter
JN439_RS01930	COG0517	IMP dehydrogenase activity
JN439_RS01930	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JN439_RS01935	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
JN439_RS01945	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
JN439_RS01950	COG1137	ATPase activity
JN439_RS01955	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
JN439_RS01965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JN439_RS01970	COG1660	Displays ATPase and GTPase activities
JN439_RS01975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JN439_RS01995	COG3964	amidohydrolase
JN439_RS02025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JN439_RS02030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JN439_RS02040	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
JN439_RS02045	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JN439_RS02050	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JN439_RS02055	COG0723	plastoquinol--plastocyanin reductase activity
JN439_RS02060	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JN439_RS02065	COG2857	Cytochrome c1
JN439_RS02070	COG0625	glutathione transferase activity
JN439_RS02075	COG2969	positive regulation of protein catabolic process
JN439_RS02085	COG2823	Periplasmic or secreted lipoprotein
JN439_RS02090	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JN439_RS02095	COG0792	nuclease activity
JN439_RS02100	COG3107	peptidoglycan biosynthetic process
JN439_RS02105	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JN439_RS02115	COG2001	Belongs to the MraZ family
JN439_RS02120	COG0275	rRNA processing
JN439_RS02125	COG3116	cell division
JN439_RS02130	COG0768	penicillin binding
JN439_RS02135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JN439_RS02140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JN439_RS02145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JN439_RS02150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JN439_RS02155	COG0772	Belongs to the SEDS family
JN439_RS02160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JN439_RS02165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JN439_RS02170	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JN439_RS02175	COG0849	cell division
JN439_RS02180	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JN439_RS02185	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
JN439_RS02195	COG0653	protein targeting
JN439_RS02205	COG0494	nUDIX hydrolase
JN439_RS02210	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
JN439_RS02215	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
JN439_RS02230	COG1459	type II secretion system
JN439_RS02235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JN439_RS02265	COG2186	Transcriptional regulator
JN439_RS02270	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JN439_RS02275	COG0508	dehydrogenase complex catalyzes the overall conversion of
JN439_RS02280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JN439_RS02290	COG0840	transmembrane signaling receptor activity
JN439_RS02295	COG1752	Esterase of the alpha-beta hydrolase superfamily
JN439_RS02300	COG1049	propionate catabolic process, 2-methylcitrate cycle
JN439_RS02320	COG1280	lysine exporter protein (LysE YggA)
JN439_RS02330	COG0523	cobalamin synthesis protein
JN439_RS02350	COG0477	Major facilitator Superfamily
JN439_RS02365	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JN439_RS02370	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JN439_RS02420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JN439_RS02430	COG1546	Belongs to the CinA family
JN439_RS02435	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JN439_RS02440	COG2137	regulation of response to DNA damage stimulus
JN439_RS02445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JN439_RS02450	COG0527	aspartate kinase activity
JN439_RS02455	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
JN439_RS02490	COG1686	Belongs to the peptidase S11 family
JN439_RS02495	COG0586	Pfam SNARE associated Golgi protein
JN439_RS02500	COG1253	flavin adenine dinucleotide binding
JN439_RS02505	COG0525	valine-tRNA ligase activity
JN439_RS02515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JN439_RS02520	COG0795	lipopolysaccharide-transporting ATPase activity
JN439_RS02525	COG0795	lipopolysaccharide-transporting ATPase activity
JN439_RS02540	COG0582	viral genome integration into host DNA
JN439_RS02605	COG1196	nuclear chromosome segregation
JN439_RS02655	COG0004	ammonium transporteR
JN439_RS02660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JN439_RS02675	COG2165	general secretion pathway protein
JN439_RS02680	COG0084	hydrolase, TatD family'
JN439_RS02685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JN439_RS02695	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JN439_RS02700	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
JN439_RS02705	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
JN439_RS02710	COG0813	purine-nucleoside phosphorylase activity
JN439_RS02715	COG5001	Diguanylate cyclase
JN439_RS02715	COG5002	protein histidine kinase activity
JN439_RS02715	COG3447	MASE1 domain protein
JN439_RS02725	COG0560	Phosphoserine phosphatase
JN439_RS02735	COG3385	transposase activity
JN439_RS02745	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JN439_RS02755	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
JN439_RS02760	COG0776	regulation of translation
JN439_RS02775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JN439_RS02780	COG0735	belongs to the Fur family
JN439_RS02800	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JN439_RS02805	COG0513	Belongs to the DEAD box helicase family
JN439_RS02810	COG3022	response to hydroperoxide
JN439_RS02825	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JN439_RS02830	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JN439_RS02835	COG0762	integral membrane protein
JN439_RS02840	COG1872	DUF167
JN439_RS02860	COG3112	Uncharacterised protein family (UPF0231)
JN439_RS02865	COG3835	regulator
JN439_RS02870	COG2610	gluconate transmembrane transporter activity
JN439_RS02875	COG1929	Belongs to the glycerate kinase type-1 family
JN439_RS02890	COG0583	DNA-binding transcription factor activity
JN439_RS02895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JN439_RS02910	COG0347	Belongs to the P(II) protein family
JN439_RS02925	COG3842	ATPase activity
JN439_RS02930	COG2837	iron assimilation
JN439_RS02935	COG1438	arginine binding
JN439_RS02940	COG1126	abc transporter atp-binding protein
JN439_RS02945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JN439_RS02950	COG4215	(ABC) transporter
JN439_RS02955	COG4160	amino acid transport
JN439_RS02960	COG0039	L-malate dehydrogenase activity
JN439_RS02965	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
JN439_RS02970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JN439_RS02970	COG1017	nitric oxide dioxygenase activity
JN439_RS02980	COG4536	flavin adenine dinucleotide binding
JN439_RS02985	COG4137	Cytochrome C assembly protein
JN439_RS02990	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JN439_RS02995	COG0228	four-way junction DNA binding
JN439_RS03000	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JN439_RS03005	COG0336	Belongs to the RNA methyltransferase TrmD family
JN439_RS03010	COG0335	large ribosomal subunit rRNA binding
JN439_RS03030	COG1051	belongs to the nudix hydrolase family
JN439_RS03040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JN439_RS03045	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JN439_RS03050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JN439_RS03060	COG0583	DNA-binding transcription factor activity
JN439_RS03065	COG0640	Transcriptional regulator
JN439_RS03070	COG0268	Binds directly to 16S ribosomal RNA
JN439_RS03075	COG0728	peptidoglycan biosynthetic process
JN439_RS03080	COG0196	riboflavin kinase activity
JN439_RS03085	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JN439_RS03090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JN439_RS03095	COG1047	Peptidyl-prolyl cis-trans
JN439_RS03100	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JN439_RS03130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JN439_RS03130	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JN439_RS03145	COG1854	S-ribosylhomocysteine lyase activity
JN439_RS03150	COG3706	GGDEF domain
JN439_RS03155	COG0557	exoribonuclease II activity
JN439_RS03160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JN439_RS03170	COG2153	protein acetylation
JN439_RS03180	COG1914	H( )-stimulated, divalent metal cation uptake system
JN439_RS03185	COG0360	Binds together with S18 to 16S ribosomal RNA
JN439_RS03190	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JN439_RS03195	COG0359	binds to the 23S rRNA
JN439_RS03235	COG1238	metal cluster binding
JN439_RS03240	COG0612	Peptidase, M16
JN439_RS03245	COG2918	glutathione biosynthetic process
JN439_RS03250	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JN439_RS03255	COG1027	Aspartate ammonia-lyase
JN439_RS03260	COG3030	protein affecting phage T7 exclusion by the F plasmid
JN439_RS03265	COG0534	Mate efflux family protein
JN439_RS03270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JN439_RS03275	COG0459	protein refolding
JN439_RS03295	COG0564	pseudouridine synthase activity
JN439_RS03300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JN439_RS03330	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
JN439_RS03345	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
JN439_RS03350	COG4208	sulfate ABC transporter
JN439_RS03355	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
JN439_RS03360	COG0583	DNA-binding transcription factor activity
JN439_RS03365	COG3397	chitin binding
JN439_RS03395	COG1328	CTP reductase activity
JN439_RS03400	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JN439_RS03415	COG1448	Aminotransferase
JN439_RS03420	COG2194	sulfuric ester hydrolase activity
JN439_RS03440	COG1215	transferase activity, transferring glycosyl groups
JN439_RS03445	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
JN439_RS03450	COG0457	Tetratricopeptide repeat
JN439_RS03450	COG3118	belongs to the thioredoxin family
JN439_RS03485	COG0513	Belongs to the DEAD box helicase family
JN439_RS03490	COG0840	transmembrane signaling receptor activity
JN439_RS03500	COG4166	transmembrane transport
JN439_RS03515	COG1024	Enoyl-CoA hydratase
JN439_RS03530	COG4221	oxidoreductase activity
JN439_RS03535	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JN439_RS03540	COG0442	prolyl-tRNA aminoacylation
JN439_RS03545	COG0840	transmembrane signaling receptor activity
JN439_RS03550	COG0632	four-way junction helicase activity
JN439_RS03555	COG2255	four-way junction helicase activity
JN439_RS03565	COG1271	oxidase subunit
JN439_RS03570	COG1294	oxidase, subunit
JN439_RS03575	COG4890	Cyd operon protein YbgT
JN439_RS03580	COG3790	cyd operon protein YbgE
JN439_RS03585	COG0824	Thioesterase
JN439_RS03590	COG0811	peptide transport
JN439_RS03605	COG0823	Involved in the tonB-independent uptake of proteins
JN439_RS03610	COG2885	chlorophyll binding
JN439_RS03615	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
JN439_RS03690	COG0840	transmembrane signaling receptor activity
JN439_RS03695	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JN439_RS03705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JN439_RS03710	COG1640	4-alpha-glucanotransferase
JN439_RS03715	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JN439_RS03745	COG2130	NADP-dependent
JN439_RS03750	COG1846	Transcriptional regulator
JN439_RS03780	COG0561	phosphatase activity
JN439_RS03795	COG0733	neurotransmitter:sodium symporter activity
JN439_RS03800	COG0733	neurotransmitter:sodium symporter activity
JN439_RS03815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JN439_RS03830	COG1794	racemase activity, acting on amino acids and derivatives
JN439_RS03840	COG1022	Amp-dependent synthetase and ligase
JN439_RS03850	COG0456	acetyltransferase
JN439_RS03865	COG2425	protein containing a von Willebrand factor type A (vWA) domain
JN439_RS03870	COG5002	protein histidine kinase activity
JN439_RS03870	COG5001	Diguanylate cyclase
JN439_RS03880	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JN439_RS03890	COG0456	acetyltransferase
JN439_RS03900	COG0456	acetyltransferase
JN439_RS03905	COG1902	pentaerythritol trinitrate reductase activity
JN439_RS03915	COG2852	Protein conserved in bacteria
JN439_RS03925	COG2957	Belongs to the agmatine deiminase family
JN439_RS03930	COG0154	amidase activity
JN439_RS03965	COG1917	Cupin 2, conserved barrel domain protein
JN439_RS03965	COG2207	Transcriptional regulator
JN439_RS03975	COG0513	Belongs to the DEAD box helicase family
JN439_RS03980	COG2199	diguanylate cyclase activity
JN439_RS03980	COG2203	Gaf domain
JN439_RS04015	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
JN439_RS04025	COG0577	efflux transmembrane transporter activity
JN439_RS04025	COG1136	(ABC) transporter
JN439_RS04030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JN439_RS04035	COG0745	RESPONSE REGULATOR receiver
JN439_RS04040	COG2205	protein histidine kinase activity
JN439_RS04090	COG1280	lysine exporter protein (LysE YggA)
JN439_RS04095	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
JN439_RS04110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JN439_RS04140	COG0745	RESPONSE REGULATOR receiver
JN439_RS04145	COG3104	oligopeptide transport
JN439_RS04150	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JN439_RS04155	COG1555	photosystem II stabilization
JN439_RS04165	COG3385	transposase activity
JN439_RS04170	COG2350	Protein conserved in bacteria
JN439_RS04175	COG2917	probably involved in intracellular septation
JN439_RS04180	COG0076	glutamate decarboxylase activity
JN439_RS04185	COG1272	protein, Hemolysin III
JN439_RS04190	COG0569	domain protein
JN439_RS04190	COG2985	domain, Protein
JN439_RS04200	COG0477	Major facilitator Superfamily
JN439_RS04205	COG0583	DNA-binding transcription factor activity
JN439_RS04210	COG3227	Zinc metalloprotease (Elastase)
JN439_RS04215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JN439_RS04220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JN439_RS04230	COG2731	YhcH YjgK YiaL family protein
JN439_RS04240	COG0668	transmembrane transport
JN439_RS04250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JN439_RS04260	COG0789	Transcriptional regulator
JN439_RS04310	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
JN439_RS04320	COG0488	(ABC) transporter
JN439_RS04325	COG0517	IMP dehydrogenase activity
JN439_RS04325	COG0516	GMP reductase activity
JN439_RS04335	COG0784	Response regulator, receiver
JN439_RS04335	COG0835	chemotaxis
JN439_RS04340	COG2755	lipolytic protein G-D-S-L family
JN439_RS04345	COG4181	ATPase activity
JN439_RS04350	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
JN439_RS04355	COG1090	epimerase
JN439_RS04360	COG2200	EAL domain
JN439_RS04365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JN439_RS04370	COG4935	Belongs to the peptidase S8 family
JN439_RS04370	COG2234	aminopeptidase activity
JN439_RS04375	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JN439_RS04380	COG3171	Protein conserved in bacteria
JN439_RS04385	COG2066	Belongs to the glutaminase family
JN439_RS04390	COG2897	thiosulfate sulfurtransferase activity
JN439_RS04400	COG1132	(ABC) transporter
JN439_RS04425	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
JN439_RS04430	COG3300	MHYT domain
JN439_RS04430	COG5001	Diguanylate cyclase
JN439_RS04450	COG4628	conserved protein (DUF2132)
JN439_RS04455	COG0688	phosphatidylethanolamine metabolic process
JN439_RS04460	COG1162	GTPase activity
JN439_RS04465	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JN439_RS04505	COG1278	Cold shock
JN439_RS04515	COG0840	transmembrane signaling receptor activity
JN439_RS04520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JN439_RS04570	COG0848	biopolymer transport protein
JN439_RS04575	COG0811	peptide transport
JN439_RS04580	COG0811	peptide transport
JN439_RS04590	COG4206	TonB-dependent receptor
JN439_RS04595	COG4174	ABC transporter (Permease)
JN439_RS04600	COG4239	(ABC) transporter, permease
JN439_RS04610	COG0444	Belongs to the ABC transporter superfamily
JN439_RS04615	COG4608	Belongs to the ABC transporter superfamily
JN439_RS04620	COG2195	Cleaves the N-terminal amino acid of tripeptides
JN439_RS04625	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
JN439_RS04630	COG1073	alpha beta
JN439_RS04645	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JN439_RS04675	COG0243	molybdopterin cofactor binding
JN439_RS04680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JN439_RS04680	COG1648	precorrin-2 dehydrogenase activity
JN439_RS04690	COG1116	anion transmembrane transporter activity
JN439_RS04690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JN439_RS04695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JN439_RS04700	COG1116	anion transmembrane transporter activity
JN439_RS04705	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JN439_RS04705	COG2146	nitrite reductase [NAD(P)H] activity
JN439_RS04710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JN439_RS04710	COG2146	nitrite reductase [NAD(P)H] activity
JN439_RS04715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JN439_RS04720	COG2313	pseudouridylate synthase activity
JN439_RS04725	COG2313	pseudouridylate synthase activity
JN439_RS04750	COG0521	Mo-molybdopterin cofactor biosynthetic process
JN439_RS04760	COG2966	Psort location CytoplasmicMembrane, score
JN439_RS04775	COG4175	Glycine betaine
JN439_RS04780	COG4176	ABC-type proline glycine betaine transport system permease component
JN439_RS04785	COG2113	Glycine betaine
JN439_RS04790	COG0175	sulfate reduction
JN439_RS04795	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JN439_RS04800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JN439_RS04810	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JN439_RS04825	COG0786	glutamate:sodium symporter activity
JN439_RS04830	COG0252	asparaginase activity
JN439_RS04835	COG3139	Protein of unknown function (DUF1315)
JN439_RS04855	COG0616	signal peptide processing
JN439_RS04860	COG0446	pyridine nucleotide-disulphide oxidoreductase
JN439_RS04860	COG1902	pentaerythritol trinitrate reductase activity
JN439_RS04865	COG0778	Nitroreductase
JN439_RS04875	COG0110	maltose O-acetyltransferase activity
JN439_RS04880	COG2264	protein methyltransferase activity
JN439_RS04885	COG0604	alcohol dehydrogenase
JN439_RS04890	COG0583	DNA-binding transcription factor activity
JN439_RS04895	COG1263	PTS System
JN439_RS04895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JN439_RS04895	COG2190	(PTS) system
JN439_RS04900	COG4145	pantothenate transmembrane transporter activity
JN439_RS04905	COG3924	membrane
JN439_RS04910	COG0439	Biotin carboxylase
JN439_RS04915	COG0511	ligase activity, forming carbon-carbon bonds
JN439_RS04920	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JN439_RS04925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JN439_RS04940	COG3381	protein complex oligomerization
JN439_RS04950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JN439_RS04960	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JN439_RS04965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JN439_RS04965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JN439_RS04980	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JN439_RS04985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JN439_RS04990	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JN439_RS04995	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JN439_RS05000	COG4172	Belongs to the ABC transporter superfamily
JN439_RS05010	COG0601	transmembrane transport
JN439_RS05015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JN439_RS05020	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JN439_RS05025	COG0142	geranyltranstransferase activity
JN439_RS05030	COG1722	exodeoxyribonuclease VII activity
JN439_RS05035	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JN439_RS05040	COG1360	Flagellar Motor Protein
JN439_RS05055	COG1534	Rna-binding protein
JN439_RS05060	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
JN439_RS05070	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JN439_RS05075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JN439_RS05080	COG0149	triose-phosphate isomerase activity
JN439_RS05085	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JN439_RS05100	COG0779	Required for maturation of 30S ribosomal subunits
JN439_RS05105	COG0195	Participates in both transcription termination and antitermination
JN439_RS05110	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JN439_RS05115	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JN439_RS05120	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JN439_RS05125	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JN439_RS05130	COG1185	polyribonucleotide nucleotidyltransferase activity
JN439_RS05135	COG2211	Major facilitator Superfamily
JN439_RS05140	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
JN439_RS05145	COG1422	Protein of unknown function (DUF1090)
JN439_RS05150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JN439_RS05155	COG0826	peptidase U32
JN439_RS05175	COG0312	modulator of DNA gyrase
JN439_RS05185	COG0312	modulator of DNA gyrase
JN439_RS05195	COG4974	Belongs to the 'phage' integrase family
JN439_RS05200	COG1970	mechanosensitive ion channel activity
JN439_RS05215	COG0789	Transcriptional regulator
JN439_RS05230	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JN439_RS05240	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JN439_RS05245	COG0321	lipoyl(octanoyl) transferase activity
JN439_RS05250	COG2921	Belongs to the UPF0250 family
JN439_RS05255	COG1686	Belongs to the peptidase S11 family
JN439_RS05260	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JN439_RS05265	COG2951	lytic endotransglycosylase activity
JN439_RS05270	COG0772	Belongs to the SEDS family
JN439_RS05275	COG0768	penicillin binding
JN439_RS05280	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JN439_RS05285	COG0799	negative regulation of ribosome biogenesis
JN439_RS05290	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JN439_RS05310	COG0495	leucyl-tRNA aminoacylation
JN439_RS05315	COG2888	peptidyl-tyrosine sulfation
JN439_RS05320	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JN439_RS05325	COG4535	Mg2 and Co2 transporter CorC
JN439_RS05330	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JN439_RS05335	COG1702	phosphate starvation-inducible protein PhoH
JN439_RS05340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JN439_RS05345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JN439_RS05350	COG1335	isochorismatase
JN439_RS05355	COG1278	Cold shock
JN439_RS05370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JN439_RS05385	COG2199	diguanylate cyclase activity
JN439_RS05395	COG3385	transposase activity
JN439_RS05400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JN439_RS05415	COG1464	Belongs to the NlpA lipoprotein family
JN439_RS05420	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JN439_RS05425	COG2011	ABC-type metal ion transport system permease component
JN439_RS05430	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JN439_RS05440	COG0516	GMP reductase activity
JN439_RS05445	COG4067	protein conserved in archaea
JN439_RS05445	COG0189	ligase activity
JN439_RS05465	COG0300	oxidoreductase activity
JN439_RS05485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JN439_RS05490	COG3214	Protein conserved in bacteria
JN439_RS05505	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
JN439_RS05510	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
JN439_RS05515	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JN439_RS05520	COG1053	succinate dehydrogenase
JN439_RS05530	COG0584	glycerophosphoryl diester phosphodiesterase
JN439_RS05535	COG1511	domain protein
JN439_RS05535	COG3264	Mechanosensitive ion channel
JN439_RS05545	COG0739	heme binding
JN439_RS05560	COG0583	DNA-binding transcription factor activity
JN439_RS05575	COG0583	DNA-binding transcription factor activity
JN439_RS05580	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JN439_RS05615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JN439_RS05620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JN439_RS05630	COG0338	D12 class N6 adenine-specific DNA methyltransferase
JN439_RS05635	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JN439_RS05640	COG0546	phosphoglycolate phosphatase activity
JN439_RS05645	COG0180	Tryptophanyl-tRNA synthetase
JN439_RS05660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JN439_RS05670	COG1012	belongs to the aldehyde dehydrogenase family
JN439_RS05685	COG2801	Transposase and inactivated derivatives
JN439_RS05690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JN439_RS05705	COG0657	acetylesterase activity
JN439_RS05715	COG0490	domain, Protein
JN439_RS05715	COG0471	metal ion transport
JN439_RS05760	COG0012	GTP binding
JN439_RS05765	COG0193	aminoacyl-tRNA hydrolase activity
JN439_RS05770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JN439_RS05780	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JN439_RS05785	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
JN439_RS05790	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JN439_RS05795	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JN439_RS05800	COG2890	protein-(glutamine-N5) methyltransferase activity
JN439_RS05810	COG2912	Transglutaminase-like superfamily
JN439_RS05815	COG2877	3-deoxy-8-phosphooctulonate synthase activity
JN439_RS05820	COG1301	dicarboxylic acid transport
JN439_RS05830	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JN439_RS05845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JN439_RS05850	COG1115	amino acid carrier protein
JN439_RS05870	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JN439_RS05880	COG0189	ligase activity
JN439_RS05885	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JN439_RS05895	COG3091	SprT-like family
JN439_RS05905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JN439_RS05915	COG2801	Transposase and inactivated derivatives
JN439_RS05935	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
JN439_RS05940	COG0739	heme binding
JN439_RS05945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JN439_RS05950	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
JN439_RS05950	COG3408	Glycogen debranching enzyme
JN439_RS05960	COG1881	PFAM PEBP family protein
JN439_RS05965	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JN439_RS05970	COG0583	DNA-binding transcription factor activity
JN439_RS05980	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JN439_RS05990	COG0583	DNA-binding transcription factor activity
JN439_RS05995	COG1028	Short-chain dehydrogenase reductase Sdr
JN439_RS06000	COG0616	signal peptide processing
JN439_RS06005	COG3724	N-succinylarginine dihydrolase activity
JN439_RS06025	COG0840	transmembrane signaling receptor activity
JN439_RS06035	COG2971	BadF BadG BcrA BcrD
JN439_RS06045	COG4608	Belongs to the ABC transporter superfamily
JN439_RS06050	COG0444	Belongs to the ABC transporter superfamily
JN439_RS06055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JN439_RS06070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JN439_RS06075	COG3039	Transposase
JN439_RS06100	COG3328	transposase activity
JN439_RS06140	COG3039	Transposase
JN439_RS06170	COG0640	Transcriptional regulator
JN439_RS06175	COG0798	PFAM Bile acid sodium symporter
JN439_RS06180	COG1393	Belongs to the ArsC family
JN439_RS06190	COG1677	Flagellar hook-basal body complex protein FliE
JN439_RS06200	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JN439_RS06255	COG1684	flagellar biosynthetic protein fliR
JN439_RS06265	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JN439_RS06290	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
JN439_RS06295	COG2198	Histidine kinase
JN439_RS06295	COG0643	Histidine kinase
JN439_RS06295	COG0784	Response regulator, receiver
JN439_RS06305	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JN439_RS06310	COG1360	Flagellar Motor Protein
JN439_RS06315	COG1192	Involved in chromosome partitioning
JN439_RS06325	COG0835	chemotaxis
JN439_RS06340	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JN439_RS06345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JN439_RS06350	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JN439_RS06355	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
JN439_RS06360	COG1138	Cytochrome C-type biogenesis protein
JN439_RS06365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JN439_RS06375	COG0457	Tetratricopeptide repeat
JN439_RS06390	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JN439_RS06395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JN439_RS06395	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JN439_RS06410	COG0259	pyridoxamine-phosphate oxidase activity
JN439_RS06440	COG3153	acetyltransferase
JN439_RS06455	COG0800	Aldolase
JN439_RS06460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JN439_RS06470	COG2721	sulfolactate sulfo-lyase activity
JN439_RS06475	COG0246	Mannitol dehydrogenase
JN439_RS06505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JN439_RS06535	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JN439_RS06545	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JN439_RS06570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JN439_RS06595	COG3039	Transposase
JN439_RS06600	COG5642	Protein of unknown function (DUF2384)
JN439_RS06605	COG2850	peptidyl-arginine hydroxylation
JN439_RS06615	COG4122	O-methyltransferase activity
JN439_RS06635	COG0210	DNA helicase
JN439_RS06635	COG0210	DNA helicase
JN439_RS06675	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JN439_RS06680	COG2867	negative regulation of translational initiation
JN439_RS06685	COG2914	Belongs to the UPF0125 (RnfH) family
JN439_RS06690	COG0702	epimerase
JN439_RS06695	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JN439_RS06700	COG1454	alcohol dehydrogenase
JN439_RS06710	COG0564	pseudouridine synthase activity
JN439_RS06715	COG1957	nucleoside hydrolase
JN439_RS06740	COG1280	lysine exporter protein (LysE YggA)
JN439_RS06750	COG3263	regulation of cellular component size
JN439_RS06760	COG1876	peptidase activity
JN439_RS06765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JN439_RS06770	COG1393	Belongs to the ArsC family
JN439_RS06775	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JN439_RS06790	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JN439_RS06815	COG5433	transposase activity
JN439_RS06820	COG3069	C4-dicarboxylate transmembrane transporter activity
JN439_RS06825	COG1473	amidohydrolase
JN439_RS06835	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JN439_RS06840	COG0017	Asparaginyl-tRNA synthetase
JN439_RS06860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JN439_RS06865	COG0156	8-amino-7-oxononanoate synthase activity
JN439_RS06870	COG1073	alpha beta
JN439_RS06870	COG2226	methyltransferase
JN439_RS06875	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JN439_RS06880	COG0501	Belongs to the peptidase M48B family
JN439_RS06885	COG3217	Mosc domain protein beta barrel domain protein
JN439_RS06885	COG0633	Ferredoxin
JN439_RS06885	COG3217	Mosc domain protein beta barrel domain protein
JN439_RS06885	COG0633	Ferredoxin
JN439_RS06895	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JN439_RS06895	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JN439_RS06895	COG1013	pyruvate-flavodoxin oxidoreductase activity
JN439_RS06895	COG0674	pyruvate-flavodoxin oxidoreductase activity
JN439_RS06900	COG2841	Protein conserved in bacteria
JN439_RS06910	COG0534	Mate efflux family protein
JN439_RS06945	COG1309	transcriptional regulator
JN439_RS06960	COG0791	NLP P60 protein
JN439_RS06965	COG0583	DNA-binding transcription factor activity
JN439_RS06985	COG0500	methyltransferase
JN439_RS06990	COG4106	trans-aconitate 2-methyltransferase activity
JN439_RS06995	COG1801	Protein of unknown function DUF72
JN439_RS07000	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JN439_RS07005	COG0217	transcriptional regulatory protein
JN439_RS07010	COG2194	sulfuric ester hydrolase activity
JN439_RS07020	COG1846	Transcriptional regulator
JN439_RS07020	COG1940	carbohydrate kinase activity
JN439_RS07025	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JN439_RS07030	COG0363	glucosamine-6-phosphate deaminase activity
JN439_RS07035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JN439_RS07035	COG1263	PTS System
JN439_RS07035	COG2190	(PTS) system
JN439_RS07045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JN439_RS07050	COG0735	belongs to the Fur family
JN439_RS07060	COG0716	FMN binding
JN439_RS07075	COG0596	Alpha beta hydrolase
JN439_RS07080	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
JN439_RS07085	COG0033	Phosphoglucomutase
JN439_RS07095	COG1846	Transcriptional regulator
JN439_RS07100	COG2951	lytic endotransglycosylase activity
JN439_RS07105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JN439_RS07110	COG4136	ATPase activity
JN439_RS07120	COG4134	Bacterial extracellular solute-binding protein
JN439_RS07125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JN439_RS07130	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JN439_RS07140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JN439_RS07150	COG0729	surface antigen
JN439_RS07155	COG2911	Protein conserved in bacteria
JN439_RS07175	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JN439_RS07185	COG0741	lytic transglycosylase activity
JN439_RS07200	COG1607	acyl-coa hydrolase
JN439_RS07250	COG3451	type IV secretory pathway VirB4
JN439_RS07260	COG3838	Conjugal transfer protein Trbc
JN439_RS07265	COG4962	Type ii secretion system protein e
JN439_RS07285	COG0583	DNA-binding transcription factor activity
JN439_RS07310	COG2076	Multidrug Resistance protein
JN439_RS07330	COG4959	Type IV secretory pathway protease TraF
JN439_RS07345	COG1192	Involved in chromosome partitioning
JN439_RS07375	COG5489	Protein of unknown function (DUF736)
JN439_RS07400	COG2003	Belongs to the UPF0758 family
JN439_RS07405	COG4804	nuclease activity
JN439_RS07415	COG1388	LysM domain
JN439_RS07415	COG0741	lytic transglycosylase activity
JN439_RS07420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JN439_RS07425	COG2226	methyltransferase
JN439_RS07430	COG0328	RNA-DNA hybrid ribonuclease activity
JN439_RS07435	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JN439_RS07445	COG0784	Response regulator, receiver
JN439_RS07445	COG3437	response regulator, receiver
JN439_RS07450	COG1960	acyl-CoA dehydrogenase activity
JN439_RS07455	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JN439_RS07460	COG0121	glutamine amidotransferase
JN439_RS07470	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JN439_RS07495	COG2197	response regulator
JN439_RS07500	COG3850	Histidine kinase
JN439_RS07505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JN439_RS07510	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
JN439_RS07510	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JN439_RS07520	COG0243	molybdopterin cofactor binding
JN439_RS07525	COG0437	4 iron, 4 sulfur cluster binding
JN439_RS07530	COG0348	domain, Protein
JN439_RS07540	COG3005	denitrification pathway
JN439_RS07545	COG0521	Mo-molybdopterin cofactor biosynthetic process
JN439_RS07550	COG0315	cyclic pyranopterin monophosphate synthase activity
JN439_RS07555	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
JN439_RS07560	COG0314	molybdopterin synthase activity
JN439_RS07575	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
JN439_RS07600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JN439_RS07610	COG0302	gtp cyclohydrolase
JN439_RS07615	COG0840	transmembrane signaling receptor activity
JN439_RS07620	COG0840	transmembrane signaling receptor activity
JN439_RS07625	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JN439_RS07635	COG0583	DNA-binding transcription factor activity
JN439_RS07655	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
JN439_RS07670	COG2195	Cleaves the N-terminal amino acid of tripeptides
JN439_RS07675	COG1166	arginine decarboxylase activity
JN439_RS07700	COG1403	HNH endonuclease
JN439_RS07705	COG5433	transposase activity
JN439_RS07720	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JN439_RS07725	COG1187	pseudouridine synthase activity
JN439_RS07730	COG2807	transmembrane transport
JN439_RS07740	COG0583	DNA-binding transcription factor activity
JN439_RS07760	COG2979	Protein of unknown function (DUF533)
JN439_RS07770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JN439_RS07775	COG1271	oxidase subunit
JN439_RS07780	COG1294	oxidase, subunit
JN439_RS07790	COG2814	Major facilitator Superfamily
JN439_RS07795	COG0656	L-ascorbic acid biosynthetic process
JN439_RS07815	COG0583	DNA-binding transcription factor activity
JN439_RS07820	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JN439_RS07825	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JN439_RS07845	COG1349	DNA-binding transcription factor activity
JN439_RS07855	COG0584	glycerophosphoryl diester phosphodiesterase
JN439_RS07860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JN439_RS07865	COG1605	Chorismate mutase
JN439_RS07865	COG0287	Prephenate dehydrogenase
JN439_RS07875	COG3085	chromosome segregation
JN439_RS07880	COG4574	serine-type endopeptidase inhibitor activity
JN439_RS07895	COG0675	Transposase, IS605 OrfB family
JN439_RS07905	COG4771	TonB-dependent receptor
JN439_RS07910	COG3083	sulfuric ester hydrolase activity
JN439_RS07915	COG3082	Protein of unknown function (DUF1414)
JN439_RS07920	COG3081	Nucleoid-associated protein
JN439_RS07930	COG1175	transmembrane transport
JN439_RS07935	COG3833	ABC-type maltose transport systems, permease component
JN439_RS07940	COG3842	ATPase activity
JN439_RS07950	COG0596	Alpha beta hydrolase
JN439_RS07965	COG0425	Belongs to the sulfur carrier protein TusA family
JN439_RS07970	COG4783	chaperone-mediated protein folding
JN439_RS07980	COG1393	Belongs to the ArsC family
JN439_RS08005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JN439_RS08010	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JN439_RS08015	COG2431	L-lysine efflux transmembrane transporter activity
JN439_RS08025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JN439_RS08035	COG4160	amino acid transport
JN439_RS08045	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JN439_RS08055	COG0446	pyridine nucleotide-disulphide oxidoreductase
JN439_RS08080	COG0628	permease
JN439_RS08085	COG2373	Large extracellular alpha-helical protein
JN439_RS08090	COG4953	penicillin-binding protein 1C
JN439_RS08100	COG0301	tRNA thio-modification
JN439_RS08100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JN439_RS08160	COG2089	acid synthase
JN439_RS08170	COG1083	cytidylyl-transferase
JN439_RS08185	COG1028	Short-chain dehydrogenase reductase Sdr
JN439_RS08190	COG0318	PFAM AMP-dependent synthetase and ligase
JN439_RS08205	COG1215	transferase activity, transferring glycosyl groups
JN439_RS08210	COG0562	UDP-galactopyranose mutase
JN439_RS08220	COG1216	Glycosyl transferase, family 2
JN439_RS08250	COG2226	methyltransferase
JN439_RS08255	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JN439_RS08260	COG1086	Polysaccharide biosynthesis protein
JN439_RS08265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JN439_RS08275	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JN439_RS08290	COG0346	lactoylglutathione lyase activity
JN439_RS08295	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JN439_RS08300	COG4660	Part of a membrane complex involved in electron transport
JN439_RS08305	COG4659	FMN binding
JN439_RS08310	COG4658	electron transport chain
JN439_RS08320	COG2878	Part of a membrane complex involved in electron transport
JN439_RS08325	COG4657	Part of a membrane complex involved in electron transport
JN439_RS08330	COG0675	Transposase, IS605 OrfB family
JN439_RS08340	COG0697	spore germination
JN439_RS08355	COG3039	Transposase
JN439_RS08360	COG1484	DNA-dependent DNA replication
JN439_RS08365	COG4584	PFAM Integrase catalytic
JN439_RS08395	COG5433	transposase activity
JN439_RS08425	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JN439_RS08445	COG0436	Aminotransferase
JN439_RS08455	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JN439_RS08460	COG2027	D-alanyl-D-alanine carboxypeptidase
JN439_RS08465	COG1061	Type III restriction enzyme res subunit
JN439_RS08470	COG1566	PFAM secretion protein HlyD family protein
JN439_RS08485	COG0675	Transposase, IS605 OrfB family
JN439_RS08490	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JN439_RS08490	COG3264	Mechanosensitive ion channel
JN439_RS08495	COG1966	Carbon starvation protein
JN439_RS08500	COG3279	Response regulator of the LytR AlgR family
JN439_RS08505	COG3275	phosphorelay sensor kinase activity
JN439_RS08515	COG1454	alcohol dehydrogenase
JN439_RS08515	COG1012	belongs to the aldehyde dehydrogenase family
JN439_RS08520	COG2095	MarC family integral membrane protein
JN439_RS08530	COG0601	transmembrane transport
JN439_RS08535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JN439_RS08540	COG0444	Belongs to the ABC transporter superfamily
JN439_RS08550	COG0861	Integral membrane protein TerC family
JN439_RS08555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JN439_RS08565	COG1301	dicarboxylic acid transport
JN439_RS08585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JN439_RS08600	COG0537	adenosine 5'-monophosphoramidase activity
JN439_RS08635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JN439_RS08640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JN439_RS08655	COG2354	Protein conserved in bacteria
JN439_RS08660	COG1164	Oligoendopeptidase f
JN439_RS08665	COG1164	Oligoendopeptidase f
JN439_RS08670	COG3150	esterase
JN439_RS08675	COG1252	NADH dehydrogenase
JN439_RS08680	COG0393	Putative heavy-metal-binding
JN439_RS08685	COG1368	sulfuric ester hydrolase activity
JN439_RS08695	COG0527	aspartate kinase activity
JN439_RS08700	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JN439_RS08700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JN439_RS08705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JN439_RS08730	COG0583	DNA-binding transcription factor activity
JN439_RS08735	COG1620	l-lactate permease
JN439_RS08740	COG0247	lactate metabolic process
JN439_RS08745	COG1139	Iron-sulfur cluster binding protein
JN439_RS08765	COG0577	efflux transmembrane transporter activity
JN439_RS08770	COG1136	(ABC) transporter
JN439_RS08790	COG2814	Major facilitator Superfamily
JN439_RS08815	COG0672	)-iron permease
JN439_RS08850	COG2308	Evidence 4 Homologs of previously reported genes of
JN439_RS08860	COG0300	oxidoreductase activity
JN439_RS08880	COG0659	secondary active sulfate transmembrane transporter activity
JN439_RS08900	COG2003	Belongs to the UPF0758 family
JN439_RS08925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JN439_RS08930	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JN439_RS08935	COG0326	Molecular chaperone. Has ATPase activity
JN439_RS08940	COG0563	adenylate kinase activity
JN439_RS08945	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JN439_RS08950	COG3788	relative of glutathione S-transferase, MAPEG superfamily
JN439_RS08955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JN439_RS08970	COG0675	Transposase, IS605 OrfB family
JN439_RS08990	COG3300	MHYT domain
JN439_RS08990	COG5001	Diguanylate cyclase
JN439_RS09015	COG1021	2,3-dihydroxybenzoate-AMP ligase
JN439_RS09020	COG1535	isochorismatase
JN439_RS09020	COG3433	isochorismatase activity
JN439_RS09025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JN439_RS09030	COG1028	Short-chain dehydrogenase reductase Sdr
JN439_RS09040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JN439_RS09065	COG1120	ATPase activity
JN439_RS09070	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JN439_RS09075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JN439_RS09080	COG4771	TonB-dependent receptor
JN439_RS09120	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JN439_RS09125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JN439_RS09130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JN439_RS09135	COG0861	Integral membrane protein TerC family
JN439_RS09150	COG1022	Amp-dependent synthetase and ligase
JN439_RS09155	COG0295	cytidine deaminase activity
JN439_RS09160	COG1346	cytolysis
JN439_RS09165	COG1380	Effector of murein hydrolase LrgA
JN439_RS09170	COG3345	alpha-galactosidase
JN439_RS09180	COG2925	Exonuclease
JN439_RS09185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JN439_RS09190	COG0392	lysyltransferase activity
JN439_RS09190	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
JN439_RS09205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JN439_RS09210	COG0436	Aminotransferase
JN439_RS09215	COG0583	DNA-binding transcription factor activity
JN439_RS09220	COG2160	L-arabinose isomerase activity
JN439_RS09230	COG1069	ribulokinase activity
JN439_RS09235	COG1879	ABC-type sugar transport system periplasmic component
JN439_RS09240	COG1129	ABC transporter
JN439_RS09245	COG1172	Belongs to the binding-protein-dependent transport system permease family
JN439_RS09255	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JN439_RS09260	COG0254	rRNA binding
JN439_RS09275	COG1451	nucleotide metabolic process
JN439_RS09290	COG3069	C4-dicarboxylate transmembrane transporter activity
JN439_RS09300	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JN439_RS09300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JN439_RS09305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JN439_RS09325	COG2009	succinate dehydrogenase
JN439_RS09330	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
JN439_RS09345	COG0567	Dehydrogenase, E1 component
JN439_RS09350	COG0508	dehydrogenase complex catalyzes the overall conversion of
JN439_RS09355	COG0045	succinate-CoA ligase (ADP-forming) activity
JN439_RS09360	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JN439_RS09365	COG2801	Transposase and inactivated derivatives
JN439_RS09385	COG2983	Belongs to the UPF0260 family
JN439_RS09390	COG1882	Formate acetyltransferase
JN439_RS09395	COG2116	formate transmembrane transporter activity
JN439_RS09400	COG1944	ATP diphosphatase activity
JN439_RS09410	COG2076	Multidrug Resistance protein
JN439_RS09415	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JN439_RS09420	COG1278	Cold shock
JN439_RS09425	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JN439_RS09430	COG0542	response to heat
JN439_RS09435	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JN439_RS09440	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
JN439_RS09445	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
JN439_RS09450	COG3134	Outer membrane lipoprotein
JN439_RS09455	COG3706	GGDEF domain
JN439_RS09460	COG0492	ferredoxin-NADP+ reductase activity
JN439_RS09465	COG0686	Belongs to the AlaDH PNT family
JN439_RS09475	COG0531	amino acid
JN439_RS09475	COG1674	ftsk spoiiie
JN439_RS09480	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
JN439_RS09485	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JN439_RS09490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JN439_RS09495	COG1286	toxin biosynthetic process
JN439_RS09500	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JN439_RS09505	COG2723	6-phospho-beta-galactosidase activity
JN439_RS09510	COG1263	PTS System
JN439_RS09510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JN439_RS09515	COG1609	Transcriptional regulator
JN439_RS09525	COG4172	Belongs to the ABC transporter superfamily
JN439_RS09535	COG4171	peptide transport system, permease
JN439_RS09550	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JN439_RS09555	COG1842	Phage shock protein A
JN439_RS09570	COG3106	COG3106 Predicted ATPase
JN439_RS09575	COG3768	UPF0283 membrane protein
JN439_RS09585	COG2154	pterin-4-alpha-carbinolamine dehydratase
JN439_RS09605	COG2885	chlorophyll binding
JN439_RS09615	COG1570	exodeoxyribonuclease VII activity
JN439_RS09675	COG3220	belongs to the UPF0276 family
JN439_RS09695	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JN439_RS09700	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
JN439_RS09710	COG1595	DNA-templated transcription, initiation
JN439_RS09720	COG3039	Transposase
JN439_RS09735	COG0517	IMP dehydrogenase activity
JN439_RS09735	COG0516	GMP reductase activity
JN439_RS09740	COG0519	Catalyzes the synthesis of GMP from XMP
JN439_RS09740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JN439_RS09765	COG1846	Transcriptional regulator
JN439_RS09775	COG0500	methyltransferase
JN439_RS09785	COG2062	phosphohistidine phosphatase, SixA
JN439_RS09795	COG0697	spore germination
JN439_RS09810	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
JN439_RS09815	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JN439_RS09825	COG4591	ABC-type transport system involved in lipoprotein release permease component
JN439_RS09830	COG1136	(ABC) transporter
JN439_RS09835	COG4591	ABC-type transport system involved in lipoprotein release permease component
JN439_RS09840	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
JN439_RS09850	COG0544	peptidyl-prolyl cis-trans isomerase activity
JN439_RS09855	COG0740	serine-type endopeptidase activity
JN439_RS09860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JN439_RS09865	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JN439_RS09870	COG0776	regulation of translation
JN439_RS09875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JN439_RS09880	COG0488	(ABC) transporter
JN439_RS09885	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JN439_RS09890	COG3162	membrane
JN439_RS09905	COG1024	Enoyl-CoA hydratase
JN439_RS09910	COG1115	amino acid carrier protein
JN439_RS09920	COG3228	Belongs to the MtfA family
JN439_RS09925	COG1584	GPR1 FUN34 yaaH family protein
JN439_RS09950	COG1024	Enoyl-CoA hydratase
JN439_RS09955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JN439_RS09960	COG1960	acyl-CoA dehydrogenase activity
JN439_RS09970	COG1960	acyl-CoA dehydrogenase activity
JN439_RS09975	COG1024	Enoyl-CoA hydratase
JN439_RS09980	COG1024	Enoyl-CoA hydratase
JN439_RS09990	COG1028	Short-chain dehydrogenase reductase Sdr
JN439_RS10000	COG0730	response to heat
JN439_RS10015	COG1172	Belongs to the binding-protein-dependent transport system permease family
JN439_RS10020	COG1172	Belongs to the binding-protein-dependent transport system permease family
JN439_RS10025	COG1129	ABC transporter
JN439_RS10030	COG3385	transposase activity
JN439_RS10035	COG1879	ABC-type sugar transport system periplasmic component
JN439_RS10040	COG0583	DNA-binding transcription factor activity
JN439_RS10055	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JN439_RS10060	COG0243	molybdopterin cofactor binding
JN439_RS10075	COG0583	DNA-binding transcription factor activity
JN439_RS10080	COG2723	6-phospho-beta-galactosidase activity
JN439_RS10090	COG0583	DNA-binding transcription factor activity
JN439_RS10105	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JN439_RS10110	COG0673	inositol 2-dehydrogenase activity
JN439_RS10115	COG0583	DNA-binding transcription factor activity
JN439_RS10125	COG1560	Kdo2-lipid A biosynthetic process
JN439_RS10130	COG1560	Kdo2-lipid A biosynthetic process
JN439_RS10145	COG0417	DNA replication proofreading
JN439_RS10275	COG0625	glutathione transferase activity
JN439_RS10280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JN439_RS10290	COG0583	DNA-binding transcription factor activity
JN439_RS10300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JN439_RS10330	COG1846	Transcriptional regulator
JN439_RS10335	COG0583	DNA-binding transcription factor activity
JN439_RS10345	COG2948	multi-organism process
JN439_RS10440	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JN439_RS10460	COG3335	DDE superfamily endonuclease
JN439_RS10485	COG3284	Transcriptional regulator
JN439_RS10500	COG1461	Dihydroxyacetone kinase
JN439_RS10505	COG2376	Dihydroxyacetone kinase
JN439_RS10510	COG2252	PERMEase
JN439_RS10540	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JN439_RS10555	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
JN439_RS10565	COG5433	transposase activity
JN439_RS10610	COG0534	Mate efflux family protein
JN439_RS10620	COG0307	riboflavin synthase, alpha
JN439_RS10635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JN439_RS10640	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
JN439_RS10645	COG0697	spore germination
JN439_RS10650	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JN439_RS10680	COG0675	Transposase, IS605 OrfB family
JN439_RS10685	COG2996	Protein conserved in bacteria
JN439_RS10700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JN439_RS10705	COG3099	Belongs to the UPF0263 family
JN439_RS10710	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
JN439_RS10715	COG2894	cell division
JN439_RS10720	COG0850	regulation of cytokinetic process
JN439_RS10725	COG3100	YcgL domain-containing protein
JN439_RS10730	COG2951	lytic endotransglycosylase activity
JN439_RS10735	COG1760	l-serine dehydratase
JN439_RS10740	COG1760	l-serine dehydratase
JN439_RS10745	COG3123	guanosine phosphorylase activity
JN439_RS10750	COG1301	dicarboxylic acid transport
JN439_RS10765	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JN439_RS10770	COG2067	long-chain fatty acid transport protein
JN439_RS10780	COG2067	long-chain fatty acid transport protein
JN439_RS10790	COG1595	DNA-templated transcription, initiation
JN439_RS10820	COG0714	Associated with various cellular activities
JN439_RS10825	COG0183	Belongs to the thiolase family
JN439_RS10830	COG1250	3-hydroxyacyl-CoA dehydrogenase
JN439_RS10830	COG1024	Enoyl-CoA hydratase
JN439_RS10840	COG4681	YaeQ
JN439_RS10860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JN439_RS10875	COG3134	Outer membrane lipoprotein
JN439_RS10890	COG0675	Transposase, IS605 OrfB family
JN439_RS10900	COG2378	regulation of single-species biofilm formation
JN439_RS10910	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JN439_RS10910	COG0140	phosphoribosyl-ATP diphosphatase activity
JN439_RS10915	COG0107	imidazoleglycerol-phosphate synthase activity
JN439_RS10920	COG2205	protein histidine kinase activity
JN439_RS10920	COG2198	Histidine kinase
JN439_RS10920	COG0784	Response regulator, receiver
JN439_RS10925	COG2199	diguanylate cyclase activity
JN439_RS10930	COG3437	response regulator, receiver
JN439_RS10935	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JN439_RS10940	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JN439_RS10945	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JN439_RS10945	COG0131	Imidazoleglycerol-phosphate dehydratase
JN439_RS10950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JN439_RS10955	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JN439_RS10960	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JN439_RS10970	COG1199	ATP-dependent helicase activity
JN439_RS10975	COG3385	transposase activity
JN439_RS10980	COG1214	PFAM Peptidase M22, glycoprotease
JN439_RS10990	COG0596	Alpha beta hydrolase
JN439_RS10995	COG0318	PFAM AMP-dependent synthetase and ligase
JN439_RS11010	COG0697	spore germination
JN439_RS11020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JN439_RS11025	COG2832	Protein of unknown function (DUF454)
JN439_RS11030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JN439_RS11040	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JN439_RS11045	COG0583	DNA-binding transcription factor activity
JN439_RS11055	COG3314	Sporulation integral membrane protein YlbJ
JN439_RS11100	COG2197	response regulator
JN439_RS11105	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JN439_RS11105	COG0617	tRNA 3'-terminal CCA addition
JN439_RS11105	COG0517	IMP dehydrogenase activity
JN439_RS11110	COG1643	Atp-dependent helicase
JN439_RS11120	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JN439_RS11135	COG0675	Transposase, IS605 OrfB family
JN439_RS11150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JN439_RS11155	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
JN439_RS11160	COG0709	Synthesizes selenophosphate from selenide and ATP
JN439_RS11175	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JN439_RS11180	COG0840	transmembrane signaling receptor activity
JN439_RS11185	COG1254	Belongs to the acylphosphatase family
JN439_RS11195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JN439_RS11195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JN439_RS11200	COG0489	protein tyrosine kinase activity
JN439_RS11205	COG0572	uridine kinase
JN439_RS11210	COG0717	Belongs to the dCTP deaminase family
JN439_RS11215	COG0306	phosphate transporter
JN439_RS11220	COG1530	ribonuclease E activity
JN439_RS11225	COG0564	pseudouridine synthase activity
JN439_RS11240	COG1399	metal-binding, possibly nucleic acid-binding protein
JN439_RS11245	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JN439_RS11250	COG0416	fatty acid biosynthetic process
JN439_RS11255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JN439_RS11265	COG1028	Short-chain dehydrogenase reductase Sdr
JN439_RS11270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JN439_RS11275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JN439_RS11280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JN439_RS11285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JN439_RS11290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JN439_RS11295	COG0470	DNA polymerase III
JN439_RS11300	COG0084	hydrolase, TatD family'
JN439_RS11315	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JN439_RS11315	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
JN439_RS11320	COG3008	intermembrane lipid transfer
JN439_RS11325	COG2995	paraquat-inducible protein a
JN439_RS11335	COG3141	response to X-ray
JN439_RS11360	COG3039	Transposase
JN439_RS11410	COG5642	Protein of unknown function (DUF2384)
JN439_RS11420	COG3328	transposase activity
JN439_RS11425	COG3385	transposase activity
JN439_RS11460	COG3039	Transposase
JN439_RS11470	COG5499	transcription regulator containing HTH domain
JN439_RS11480	COG1067	ATP-dependent peptidase activity
JN439_RS11485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JN439_RS11500	COG0488	(ABC) transporter
JN439_RS11510	COG0116	Belongs to the methyltransferase superfamily
JN439_RS11510	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JN439_RS11520	COG0167	dihydroorotate dehydrogenase activity
JN439_RS11525	COG2902	Dehydrogenase
JN439_RS11535	COG0308	aminopeptidase N
JN439_RS11545	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
JN439_RS11550	COG1956	GAF domain-containing protein
JN439_RS11565	COG3278	Belongs to the heme-copper respiratory oxidase family
JN439_RS11580	COG2010	Cytochrome c
JN439_RS11590	COG2217	Heavy metal translocating P-type atpase
JN439_RS11605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JN439_RS11610	COG0589	response to stress
JN439_RS11615	COG0037	tRNA processing
JN439_RS11630	COG0625	glutathione transferase activity
JN439_RS11635	COG1869	D-ribose catabolic process
JN439_RS11640	COG1129	ABC transporter
JN439_RS11645	COG1172	Belongs to the binding-protein-dependent transport system permease family
JN439_RS11650	COG1879	ABC-type sugar transport system periplasmic component
JN439_RS11655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JN439_RS11660	COG1609	Transcriptional regulator
JN439_RS11695	COG0776	regulation of translation
JN439_RS11700	COG0072	phenylalanine-tRNA ligase activity
JN439_RS11700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JN439_RS11705	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JN439_RS11710	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JN439_RS11715	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JN439_RS11720	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JN439_RS11725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JN439_RS11765	COG0675	Transposase, IS605 OrfB family
JN439_RS11790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JN439_RS11800	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JN439_RS11805	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JN439_RS11810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JN439_RS11815	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
JN439_RS11820	COG3313	Fe-S protein
JN439_RS11825	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
JN439_RS11825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JN439_RS11825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JN439_RS11830	COG1105	Belongs to the carbohydrate kinase PfkB family
JN439_RS11835	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JN439_RS11835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JN439_RS11840	COG1609	Transcriptional regulator
JN439_RS11845	COG0814	amino acid
JN439_RS11860	COG0513	Belongs to the DEAD box helicase family
JN439_RS11870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JN439_RS11875	COG2890	protein-(glutamine-N5) methyltransferase activity
JN439_RS11880	COG2840	Smr protein MutS2
JN439_RS11915	COG2824	Alkylphosphonate utilization operon protein PhnA
JN439_RS11940	COG0675	Transposase, IS605 OrfB family
JN439_RS11950	COG0588	phosphoglycerate mutase activity
JN439_RS11975	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JN439_RS11980	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
JN439_RS11990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JN439_RS11995	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JN439_RS12005	COG0205	6-phosphofructokinase activity
JN439_RS12010	COG1473	amidohydrolase
JN439_RS12015	COG1011	Hydrolase
JN439_RS12020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JN439_RS12060	COG3593	DNA synthesis involved in DNA repair
JN439_RS12075	COG0583	DNA-binding transcription factor activity
JN439_RS12080	COG0730	response to heat
JN439_RS12090	COG3148	PFAM DTW domain containing protein
JN439_RS12095	COG1181	Belongs to the D-alanine--D-alanine ligase family
JN439_RS12105	COG0386	Belongs to the glutathione peroxidase family
JN439_RS12110	COG0513	Belongs to the DEAD box helicase family
JN439_RS12125	COG1742	UPF0060 membrane protein
JN439_RS12150	COG2329	Antibiotic biosynthesis monooxygenase
JN439_RS12155	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
JN439_RS12175	COG3243	poly(R)-hydroxyalkanoic acid synthase
JN439_RS12185	COG2501	S4 domain
JN439_RS12200	COG1132	(ABC) transporter
JN439_RS12205	COG1132	(ABC) transporter
JN439_RS12220	COG3118	belongs to the thioredoxin family
JN439_RS12225	COG0471	metal ion transport
JN439_RS12235	COG0058	SHG alpha-glucan phosphorylase activity
JN439_RS12270	COG0814	amino acid
JN439_RS12275	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
JN439_RS12280	COG0514	ATP-dependent DNA helicase (RecQ)
JN439_RS12285	COG2766	serine protein kinase
JN439_RS12290	COG2718	Belongs to the UPF0229 family
JN439_RS12295	COG2719	SpoVR family
JN439_RS12300	COG2186	Transcriptional regulator
JN439_RS12305	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JN439_RS12310	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
JN439_RS12315	COG0586	Pfam SNARE associated Golgi protein
JN439_RS12325	COG0556	nucleotide-excision repair
JN439_RS12335	COG0569	domain protein
JN439_RS12335	COG2985	domain, Protein
JN439_RS12345	COG0675	Transposase, IS605 OrfB family
JN439_RS12370	COG4565	transcriptional regulatory protein
JN439_RS12375	COG3290	protein histidine kinase activity
JN439_RS12380	COG1846	Transcriptional regulator
JN439_RS12380	COG1940	carbohydrate kinase activity
JN439_RS12390	COG3012	SEC-C Motif Domain Protein
JN439_RS12395	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JN439_RS12400	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
JN439_RS12405	COG0247	lactate metabolic process
JN439_RS12415	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
JN439_RS12420	COG0437	4 iron, 4 sulfur cluster binding
JN439_RS12425	COG3301	Polysulphide reductase, NrfD
JN439_RS12430	COG1138	Cytochrome C-type biogenesis protein
JN439_RS12435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JN439_RS12440	COG3088	subunit of a heme lyase
JN439_RS12440	COG4235	cytochrome complex assembly
JN439_RS12455	COG3046	protein related to deoxyribodipyrimidine photolyase
JN439_RS12460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JN439_RS12475	COG0617	tRNA 3'-terminal CCA addition
JN439_RS12475	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JN439_RS12475	COG0517	IMP dehydrogenase activity
JN439_RS12485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JN439_RS12490	COG0583	DNA-binding transcription factor activity
JN439_RS12500	COG4774	siderophore transport
JN439_RS12505	COG2203	Gaf domain
JN439_RS12505	COG2199	diguanylate cyclase activity
JN439_RS12510	COG2200	EAL domain
JN439_RS12515	COG1917	Cupin 2, conserved barrel domain protein
JN439_RS12515	COG4977	sequence-specific DNA binding
JN439_RS12520	COG0583	DNA-binding transcription factor activity
JN439_RS12525	COG2910	NAD(P)H-binding
JN439_RS12535	COG0626	cystathionine gamma-synthase activity
JN439_RS12540	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JN439_RS12625	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
JN439_RS12630	COG0830	nickel cation binding
JN439_RS12640	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
JN439_RS12645	COG0804	urea catabolic process
JN439_RS12650	COG0832	Belongs to the urease beta subunit family
JN439_RS12655	COG0831	urea catabolic process
JN439_RS12660	COG0829	nickel cation binding
JN439_RS12670	COG0411	ABC transporter
JN439_RS12700	COG0784	Response regulator, receiver
JN439_RS12700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JN439_RS12700	COG2198	Histidine kinase
JN439_RS12700	COG2205	protein histidine kinase activity
JN439_RS12705	COG0745	RESPONSE REGULATOR receiver
JN439_RS12725	COG3039	Transposase
JN439_RS12745	COG0675	Transposase, IS605 OrfB family
JN439_RS12820	COG3550	peptidyl-serine autophosphorylation
JN439_RS12845	COG3039	Transposase
JN439_RS12905	COG1435	thymidine kinase activity
JN439_RS12910	COG1757	Na H antiporter
JN439_RS12915	COG2916	Histone family protein nucleoid-structuring protein H-NS
JN439_RS12920	COG2096	Adenosyltransferase
JN439_RS12925	COG3530	Putative quorum-sensing-regulated virulence factor
JN439_RS12930	COG0602	queuosine metabolic process
JN439_RS12935	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JN439_RS12955	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
JN439_RS12965	COG0776	regulation of translation
JN439_RS12970	COG0539	negative regulation of cytoplasmic translation
JN439_RS12975	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JN439_RS12980	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JN439_RS13010	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JN439_RS13015	COG5001	Diguanylate cyclase
JN439_RS13015	COG3300	MHYT domain
JN439_RS13030	COG0745	RESPONSE REGULATOR receiver
JN439_RS13055	COG4989	oxidoreductase activity
JN439_RS13060	COG0724	RNA recognition motif
JN439_RS13070	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
JN439_RS13080	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
JN439_RS13100	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JN439_RS13105	COG1360	Flagellar Motor Protein
JN439_RS13110	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JN439_RS13115	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JN439_RS13120	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JN439_RS13120	COG0649	NAD binding
JN439_RS13135	COG1034	ATP synthesis coupled electron transport
JN439_RS13140	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JN439_RS13145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JN439_RS13150	COG0839	Belongs to the complex I subunit 6 family
JN439_RS13155	COG0713	ATP synthesis coupled electron transport
JN439_RS13165	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JN439_RS13170	COG1007	ATP synthesis coupled electron transport
JN439_RS13175	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JN439_RS13175	COG0047	phosphoribosylformylglycinamidine synthase activity
JN439_RS13180	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
JN439_RS13190	COG1645	bacterial-type flagellum-dependent swarming motility
JN439_RS13195	COG1160	GTP binding
JN439_RS13200	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JN439_RS13205	COG2976	Protein conserved in bacteria
JN439_RS13210	COG0124	histidyl-tRNA synthetase
JN439_RS13220	COG1426	Protein conserved in bacteria
JN439_RS13230	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JN439_RS13235	COG0105	UTP biosynthetic process
JN439_RS13250	COG0633	Ferredoxin
JN439_RS13255	COG0443	Heat shock 70 kDa protein
JN439_RS13260	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JN439_RS13270	COG0822	iron-sulfur transferase activity
JN439_RS13275	COG1104	cysteine desulfurase activity
JN439_RS13290	COG3154	lipid carrier protein
JN439_RS13295	COG0826	peptidase U32
JN439_RS13300	COG0826	peptidase U32
JN439_RS13315	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JN439_RS13320	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JN439_RS13325	COG1862	Preprotein translocase
JN439_RS13330	COG0343	queuine tRNA-ribosyltransferase activity
JN439_RS13335	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JN439_RS13340	COG0517	IMP dehydrogenase activity
JN439_RS13345	COG0450	alkyl hydroperoxide reductase
JN439_RS13350	COG3634	alkyl hydroperoxide reductase activity
JN439_RS13355	COG0477	Major facilitator Superfamily
JN439_RS13390	COG5642	Protein of unknown function (DUF2384)
JN439_RS13410	COG3385	transposase activity
JN439_RS13435	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JN439_RS13440	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JN439_RS13460	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JN439_RS13460	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JN439_RS13465	COG0509	glycine decarboxylation via glycine cleavage system
JN439_RS13470	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JN439_RS13475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JN439_RS13480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JN439_RS13500	COG2814	Major facilitator Superfamily
JN439_RS13510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JN439_RS13515	COG0601	transmembrane transport
JN439_RS13525	COG0625	glutathione transferase activity
JN439_RS13530	COG0625	glutathione transferase activity
JN439_RS13540	COG0483	inositol monophosphate 1-phosphatase activity
JN439_RS13555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JN439_RS13560	COG2056	Na+-H+ antiporter family
JN439_RS13565	COG2814	Major facilitator Superfamily
JN439_RS13570	COG0583	DNA-binding transcription factor activity
JN439_RS13575	COG5001	Diguanylate cyclase
JN439_RS13590	COG2050	protein possibly involved in aromatic compounds catabolism
JN439_RS13600	COG0247	lactate metabolic process
JN439_RS13600	COG0277	FAD linked oxidase domain protein
JN439_RS13615	COG3039	Transposase
JN439_RS13620	COG1253	flavin adenine dinucleotide binding
JN439_RS13625	COG1902	pentaerythritol trinitrate reductase activity
JN439_RS13635	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JN439_RS13640	COG0647	UMP catabolic process
JN439_RS13650	COG0367	asparagine synthase
JN439_RS13665	COG0625	glutathione transferase activity
JN439_RS13675	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
JN439_RS13690	COG0564	pseudouridine synthase activity
JN439_RS13695	COG5001	Diguanylate cyclase
JN439_RS13705	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
JN439_RS13740	COG0670	Belongs to the BI1 family
JN439_RS13745	COG1289	transmembrane transporter activity
JN439_RS13750	COG2920	part of a sulfur-relay system
JN439_RS13755	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
JN439_RS13760	COG0285	dihydrofolate synthase activity
JN439_RS13765	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JN439_RS13770	COG0101	tRNA pseudouridine synthase activity
JN439_RS13780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JN439_RS13785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JN439_RS13795	COG1464	Belongs to the NlpA lipoprotein family
JN439_RS13820	COG1119	ATPase activity
JN439_RS13825	COG0574	Belongs to the PEP-utilizing enzyme family
JN439_RS13825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JN439_RS13830	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JN439_RS13840	COG1113	amino acid transport
JN439_RS13885	COG5433	transposase activity
JN439_RS13910	COG1242	4 iron, 4 sulfur cluster binding
JN439_RS13915	COG0067	glutamate synthase
JN439_RS13915	COG0070	glutamate synthase
JN439_RS13915	COG0069	glutamate synthase activity
JN439_RS13920	COG0493	'glutamate synthase
JN439_RS13925	COG1126	abc transporter atp-binding protein
JN439_RS13930	COG0765	amino acid transport
JN439_RS13935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JN439_RS13960	COG4104	PAAR repeat-containing protein
JN439_RS13970	COG0513	Belongs to the DEAD box helicase family
JN439_RS13995	COG3039	Transposase
JN439_RS14010	COG3706	GGDEF domain
JN439_RS14015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JN439_RS14025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JN439_RS14030	COG0505	Belongs to the CarA family
JN439_RS14035	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JN439_RS14045	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JN439_RS14050	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JN439_RS14055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JN439_RS14060	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JN439_RS14065	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JN439_RS14070	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
JN439_RS14075	COG4139	cobalamin transport
JN439_RS14100	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
JN439_RS14110	COG0023	Translation Initiation Factor
JN439_RS14115	COG2119	membrane
JN439_RS14150	COG2203	Gaf domain
JN439_RS14150	COG2199	diguanylate cyclase activity
JN439_RS14155	COG3039	Transposase
JN439_RS14170	COG0215	cysteine-tRNA ligase activity
JN439_RS14175	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JN439_RS14185	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JN439_RS14190	COG2261	transglycosylase associated protein
JN439_RS14195	COG1309	transcriptional regulator
JN439_RS14200	COG0604	alcohol dehydrogenase
JN439_RS14215	COG0583	DNA-binding transcription factor activity
JN439_RS14240	COG0322	excinuclease ABC activity
JN439_RS14245	COG2197	response regulator
JN439_RS14250	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
JN439_RS14255	COG2835	tetraacyldisaccharide 4'-kinase activity
JN439_RS14260	COG1663	tetraacyldisaccharide 4'-kinase activity
JN439_RS14265	COG1132	(ABC) transporter
JN439_RS14285	COG0433	COG0433 Predicted ATPase
JN439_RS14290	COG1448	Aminotransferase
JN439_RS14305	COG1199	ATP-dependent helicase activity
JN439_RS14315	COG0123	including yeast histone deacetylase and acetoin utilization protein
JN439_RS14320	COG0477	Major facilitator Superfamily
JN439_RS14325	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JN439_RS14330	COG1785	Belongs to the alkaline phosphatase family
JN439_RS14350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JN439_RS14360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JN439_RS14365	COG0765	amino acid transport
JN439_RS14370	COG1126	abc transporter atp-binding protein
JN439_RS14380	COG0531	amino acid
JN439_RS14395	COG1253	flavin adenine dinucleotide binding
JN439_RS14400	COG0704	Plays a role in the regulation of phosphate uptake
JN439_RS14405	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JN439_RS14410	COG0581	inorganic phosphate transmembrane transporter activity
JN439_RS14415	COG0573	inorganic phosphate transmembrane transporter activity
JN439_RS14420	COG0590	tRNA wobble adenosine to inosine editing
JN439_RS14435	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
JN439_RS14445	COG0675	Transposase, IS605 OrfB family
JN439_RS14465	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JN439_RS14470	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JN439_RS14475	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JN439_RS14480	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JN439_RS14505	COG2716	regulation of RNA biosynthetic process
JN439_RS14510	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JN439_RS14520	COG2239	Acts as a magnesium transporter
JN439_RS14535	COG1705	Flagellar rod assembly protein muramidase FlgJ
JN439_RS14535	COG3951	Flagellar rod assembly protein muramidase FlgJ
JN439_RS14540	COG1706	bacterial-type flagellum-dependent cell motility
JN439_RS14545	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
JN439_RS14560	COG1749	Flagellar hook protein flgE
JN439_RS14575	COG1815	bacterial-type flagellum-dependent cell motility
JN439_RS14580	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JN439_RS14585	COG0835	chemotaxis
JN439_RS14585	COG0784	Response regulator, receiver
JN439_RS14590	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
JN439_RS14605	COG0622	Phosphoesterase
JN439_RS14610	COG0675	Transposase, IS605 OrfB family
JN439_RS14620	COG4166	transmembrane transport
JN439_RS14635	COG0675	Transposase, IS605 OrfB family
JN439_RS14645	COG0697	spore germination
JN439_RS14680	COG1278	Cold shock
JN439_RS14695	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JN439_RS14720	COG3132	Protein of unknown function, DUF480
JN439_RS14730	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JN439_RS14750	COG3206	protein involved in exopolysaccharide biosynthesis
JN439_RS14750	COG0489	protein tyrosine kinase activity
JN439_RS14755	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JN439_RS14835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JN439_RS14845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JN439_RS14900	COG1091	dTDP-4-dehydrorhamnose reductase activity
JN439_RS14910	COG3039	Transposase
JN439_RS14930	COG1737	Transcriptional regulator
JN439_RS14935	COG0469	pyruvate kinase activity
JN439_RS14945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JN439_RS14950	COG1960	acyl-CoA dehydrogenase activity
JN439_RS14960	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JN439_RS14985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JN439_RS14990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JN439_RS14995	COG1309	transcriptional regulator
JN439_RS15010	COG1946	Acyl-CoA thioesterase
JN439_RS15025	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JN439_RS15035	COG0009	L-threonylcarbamoyladenylate synthase
JN439_RS15040	COG0613	PHP domain protein
JN439_RS15045	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JN439_RS15055	COG0512	Glutamine amidotransferase of anthranilate synthase
JN439_RS15055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JN439_RS15060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JN439_RS15065	COG0135	phosphoribosylanthranilate isomerase activity
JN439_RS15065	COG0134	indole-3-glycerol-phosphate synthase activity
JN439_RS15070	COG0133	tryptophan synthase activity
JN439_RS15075	COG0159	tryptophan synthase activity
JN439_RS15085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JN439_RS15095	COG1396	sequence-specific DNA binding
JN439_RS15100	COG3550	peptidyl-serine autophosphorylation
JN439_RS15120	COG0583	DNA-binding transcription factor activity
JN439_RS15130	COG5507	3-demethylubiquinone-9 3-methyltransferase
JN439_RS15135	COG2814	Major facilitator Superfamily
JN439_RS15140	COG0109	protoheme IX farnesyltransferase activity
JN439_RS15145	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JN439_RS15150	COG1845	cytochrome c oxidase, subunit III
JN439_RS15155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JN439_RS15160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JN439_RS15165	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JN439_RS15170	COG0583	DNA-binding transcription factor activity
JN439_RS15190	COG1846	Transcriptional regulator
JN439_RS15205	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
JN439_RS15220	COG0745	RESPONSE REGULATOR receiver
JN439_RS15230	COG0708	Exodeoxyribonuclease III
JN439_RS15240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JN439_RS15245	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JN439_RS15260	COG0095	Lipoate-protein ligase
JN439_RS15290	COG0640	Transcriptional regulator
JN439_RS15300	COG0446	pyridine nucleotide-disulphide oxidoreductase
JN439_RS15310	COG1285	pathogenesis
JN439_RS15340	COG0484	heat shock protein binding
JN439_RS15345	COG0443	Heat shock 70 kDa protein
JN439_RS15350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JN439_RS15355	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JN439_RS15360	COG3706	GGDEF domain
JN439_RS15365	COG0497	DNA recombination
JN439_RS15375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JN439_RS15380	COG0577	efflux transmembrane transporter activity
JN439_RS15380	COG1136	(ABC) transporter
JN439_RS15385	COG1538	Outer membrane efflux protein
JN439_RS15390	COG2375	cellular response to nickel ion
JN439_RS15395	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JN439_RS15400	COG2916	Histone family protein nucleoid-structuring protein H-NS
JN439_RS15405	COG0583	DNA-binding transcription factor activity
JN439_RS15410	COG3048	D-serine ammonia-lyase activity
JN439_RS15420	COG0538	isocitrate dehydrogenase activity
JN439_RS15455	COG0456	acetyltransferase
JN439_RS15460	COG1187	pseudouridine synthase activity
JN439_RS15470	COG0482	sulfurtransferase activity
JN439_RS15475	COG2915	High frequency lysogenization protein hflD homolog
JN439_RS15480	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JN439_RS15485	COG2850	peptidyl-arginine hydroxylation
JN439_RS15495	COG3264	Mechanosensitive ion channel
JN439_RS15495	COG1196	nuclear chromosome segregation
JN439_RS15525	COG0281	malic enzyme
JN439_RS15530	COG0746	molybdenum cofactor guanylyltransferase activity
JN439_RS15535	COG1763	Mo-molybdopterin cofactor biosynthetic process
JN439_RS15540	COG1289	transmembrane transporter activity
JN439_RS15545	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JN439_RS15575	COG3220	belongs to the UPF0276 family
JN439_RS15590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JN439_RS15630	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JN439_RS15635	COG0083	homoserine kinase activity
JN439_RS15645	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
JN439_RS15650	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
JN439_RS15665	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JN439_RS15675	COG0745	RESPONSE REGULATOR receiver
JN439_RS15690	COG4988	ABC transporter
JN439_RS15695	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JN439_RS15720	COG1720	tRNA m6t6A37 methyltransferase activity
JN439_RS15735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JN439_RS15740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JN439_RS15745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JN439_RS15755	COG2190	(PTS) system
JN439_RS15760	COG3038	cytochrome b561
JN439_RS15770	COG0420	3'-5' exonuclease activity
JN439_RS15775	COG1247	-acetyltransferase
JN439_RS15780	COG2974	May be involved in recombination
JN439_RS15790	COG0405	Gamma-glutamyltransferase
JN439_RS15795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JN439_RS15795	COG4651	solute:proton antiporter activity
JN439_RS15840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JN439_RS15845	COG1396	sequence-specific DNA binding
JN439_RS15845	COG1917	Cupin 2, conserved barrel domain protein
JN439_RS15850	COG1012	belongs to the aldehyde dehydrogenase family
JN439_RS15865	COG0531	amino acid
JN439_RS15870	COG0531	amino acid
JN439_RS15880	COG1283	sodium-dependent phosphate transmembrane transporter activity
JN439_RS15890	COG3384	dioxygenase
JN439_RS15920	COG0784	Response regulator, receiver
JN439_RS15920	COG2205	protein histidine kinase activity
JN439_RS15925	COG0582	viral genome integration into host DNA
JN439_RS15955	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JN439_RS15990	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JN439_RS15995	COG3041	Addiction module toxin RelE StbE family
JN439_RS16045	COG5002	protein histidine kinase activity
JN439_RS16045	COG2176	DNA-directed DNA polymerase activity
JN439_RS16080	COG1192	Involved in chromosome partitioning
JN439_RS16095	COG0840	transmembrane signaling receptor activity
JN439_RS16115	COG1388	LysM domain
JN439_RS16115	COG1376	ErfK ybiS ycfS ynhG family protein
JN439_RS16130	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
JN439_RS16135	COG0791	NLP P60 protein
JN439_RS16145	COG3118	belongs to the thioredoxin family
JN439_RS16155	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JN439_RS16160	COG0788	formyltetrahydrofolate deformylase activity
JN439_RS16185	COG0739	heme binding
JN439_RS16185	COG0741	lytic transglycosylase activity
JN439_RS16185	COG1196	nuclear chromosome segregation
JN439_RS16195	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JN439_RS16200	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JN439_RS16205	COG0673	inositol 2-dehydrogenase activity
JN439_RS16230	COG1032	radical SAM domain protein
JN439_RS16235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JN439_RS16245	COG3706	GGDEF domain
JN439_RS16250	COG1752	Esterase of the alpha-beta hydrolase superfamily
JN439_RS16255	COG0733	neurotransmitter:sodium symporter activity
JN439_RS16285	COG0281	malic enzyme
JN439_RS16290	COG2207	Transcriptional regulator
JN439_RS16310	COG2233	PERMEase
JN439_RS16315	COG0095	Lipoate-protein ligase
JN439_RS16320	COG1115	amino acid carrier protein
JN439_RS16325	COG0019	diaminopimelate decarboxylase activity
JN439_RS16335	COG0678	peroxiredoxin activity
JN439_RS16340	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
JN439_RS16350	COG1126	abc transporter atp-binding protein
JN439_RS16355	COG0765	amino acid transport
JN439_RS16360	COG4597	amino acid ABC transporter
JN439_RS16365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JN439_RS16385	COG0545	Peptidyl-prolyl cis-trans isomerase
JN439_RS16420	COG4783	chaperone-mediated protein folding
JN439_RS16430	COG5002	protein histidine kinase activity
JN439_RS16435	COG0745	RESPONSE REGULATOR receiver
JN439_RS16440	COG0346	lactoylglutathione lyase activity
JN439_RS16445	COG3706	GGDEF domain
JN439_RS16450	COG3284	Transcriptional regulator
JN439_RS16465	COG0697	spore germination
JN439_RS16475	COG0667	Aldo Keto reductase
JN439_RS16490	COG3290	protein histidine kinase activity
JN439_RS16500	COG1566	PFAM secretion protein HlyD family protein
JN439_RS16525	COG0602	queuosine metabolic process
JN439_RS16530	COG1328	CTP reductase activity
JN439_RS16540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JN439_RS16545	COG3115	cell septum assembly
JN439_RS16550	COG1196	nuclear chromosome segregation
JN439_RS16560	COG2860	membrane
JN439_RS16570	COG3108	Peptidase M15
JN439_RS16575	COG2989	Protein conserved in bacteria
JN439_RS16590	COG0463	Glycosyl transferase, family 2
JN439_RS16605	COG0366	Alpha amylase catalytic
JN439_RS16640	COG3706	GGDEF domain
JN439_RS16645	COG0037	tRNA processing
JN439_RS16660	COG0488	(ABC) transporter
JN439_RS16670	COG0531	amino acid
JN439_RS16675	COG0814	amino acid
JN439_RS16690	COG0825	malonyl-CoA metabolic process
JN439_RS16695	COG0587	DNA-directed DNA polymerase activity
JN439_RS16700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JN439_RS16705	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JN439_RS16710	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JN439_RS16715	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JN439_RS16720	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JN439_RS16735	COG0750	zinc metalloprotease
JN439_RS16740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JN439_RS16745	COG0575	Belongs to the CDS family
JN439_RS16750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JN439_RS16755	COG0233	cytoplasmic translational termination
JN439_RS16760	COG0528	UMP kinase activity
JN439_RS16765	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JN439_RS16770	COG0052	Belongs to the universal ribosomal protein uS2 family
JN439_RS16775	COG0024	Methionine aminopeptidase
JN439_RS16780	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
JN439_RS16785	COG2171	N-acyltransferase activity
JN439_RS16795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JN439_RS16795	COG1263	PTS System
JN439_RS16805	COG4580	involved in the transport of maltose and maltodextrins
JN439_RS16815	COG0564	pseudouridine synthase activity
JN439_RS16820	COG3098	single-species biofilm formation
JN439_RS16845	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
JN439_RS16855	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JN439_RS16855	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JN439_RS16870	COG1611	Belongs to the LOG family
JN439_RS16875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JN439_RS16880	COG0473	3-isopropylmalate dehydrogenase activity
JN439_RS16890	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
JN439_RS16895	COG2363	Small membrane protein
JN439_RS16905	COG0583	DNA-binding transcription factor activity
JN439_RS16910	COG0840	transmembrane signaling receptor activity
JN439_RS16915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JN439_RS16930	COG1477	protein flavinylation
JN439_RS16935	COG2871	sodium ion transport
JN439_RS16940	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JN439_RS16945	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JN439_RS16950	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JN439_RS16955	COG1805	sodium ion transport
JN439_RS16960	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JN439_RS16965	COG0271	Belongs to the BolA IbaG family
JN439_RS16970	COG2813	Specifically methylates the guanine in position
JN439_RS16980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JN439_RS16990	COG2211	Major facilitator Superfamily
JN439_RS17000	COG1666	GTP binding
JN439_RS17005	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JN439_RS17015	COG1393	Belongs to the ArsC family
JN439_RS17020	COG0798	PFAM Bile acid sodium symporter
JN439_RS17030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JN439_RS17055	COG0582	viral genome integration into host DNA
JN439_RS17065	COG3335	DDE superfamily endonuclease
JN439_RS17080	COG3311	Transcriptional regulator
JN439_RS17090	COG1196	nuclear chromosome segregation
JN439_RS17200	COG2003	Belongs to the UPF0758 family
JN439_RS17250	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JN439_RS17265	COG2189	Belongs to the N(4) N(6)-methyltransferase family
JN439_RS17285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JN439_RS17290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JN439_RS17295	COG1151	hydroxylamine reductase activity
JN439_RS17300	COG0783	Belongs to the Dps family
JN439_RS17325	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JN439_RS17340	COG4221	oxidoreductase activity
JN439_RS17350	COG0415	Belongs to the DNA photolyase family
JN439_RS17355	COG0789	Transcriptional regulator
JN439_RS17360	COG3272	Protein of unknown function (DUF1722)
JN439_RS17385	COG0077	Prephenate dehydratase
JN439_RS17385	COG1605	Chorismate mutase
JN439_RS17420	COG3039	Transposase
JN439_RS17480	COG1484	DNA-dependent DNA replication
JN439_RS17485	COG4584	PFAM Integrase catalytic
JN439_RS17520	COG2916	Histone family protein nucleoid-structuring protein H-NS
JN439_RS17525	COG3039	Transposase
JN439_RS17550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JN439_RS17615	COG2133	pyrroloquinoline quinone binding
JN439_RS17625	COG1349	DNA-binding transcription factor activity
JN439_RS17630	COG2084	Dehydrogenase
JN439_RS17640	COG0235	Class ii aldolase
JN439_RS17645	COG3622	Belongs to the hyi family
JN439_RS17650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JN439_RS17655	COG2610	gluconate transmembrane transporter activity
JN439_RS17675	COG0300	oxidoreductase activity
JN439_RS17700	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
JN439_RS17710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JN439_RS17720	COG3813	Protein conserved in bacteria
JN439_RS17730	COG0826	peptidase U32
JN439_RS17740	COG1280	lysine exporter protein (LysE YggA)
JN439_RS17750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JN439_RS17785	COG3275	phosphorelay sensor kinase activity
JN439_RS17790	COG3279	Response regulator of the LytR AlgR family
JN439_RS17795	COG1966	Carbon starvation protein
JN439_RS17820	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
JN439_RS17835	COG4263	nitrous-oxide reductase activity
JN439_RS17840	COG0348	domain, Protein
JN439_RS17840	COG3901	Regulator of nitric oxide reductase transcription
JN439_RS17845	COG0114	fumarate hydratase activity
JN439_RS17855	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
JN439_RS17855	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
JN439_RS17855	COG0506	proline dehydrogenase activity
JN439_RS17860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JN439_RS17875	COG0737	Belongs to the 5'-nucleotidase family
JN439_RS17895	COG2204	response regulator
JN439_RS17900	COG0545	Peptidyl-prolyl cis-trans isomerase
JN439_RS17910	COG2900	Belongs to the SlyX family
JN439_RS17915	COG1047	Peptidyl-prolyl cis-trans
JN439_RS17920	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
JN439_RS17930	COG0835	chemotaxis
JN439_RS17930	COG0784	Response regulator, receiver
JN439_RS17935	COG0429	hydrolase of the alpha beta-hydrolase fold
JN439_RS17940	COG5001	Diguanylate cyclase
JN439_RS17940	COG4251	negative regulation of phosphorylation
JN439_RS17940	COG3706	GGDEF domain
JN439_RS17940	COG2203	Gaf domain
JN439_RS17945	COG3089	Belongs to the UPF0270 family
JN439_RS17950	COG3954	Phosphoribulokinase
JN439_RS17965	COG1765	OsmC-like protein
JN439_RS17975	COG2226	methyltransferase
JN439_RS17995	COG2205	protein histidine kinase activity
JN439_RS18000	COG2814	Major facilitator Superfamily
JN439_RS18025	COG0748	coenzyme F420 binding
JN439_RS18030	COG3721	Heme iron utilization protein
JN439_RS18040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JN439_RS18065	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JN439_RS18075	COG0463	Glycosyl transferase, family 2
JN439_RS18080	COG0741	lytic transglycosylase activity
JN439_RS18080	COG0739	heme binding
JN439_RS18080	COG1196	nuclear chromosome segregation
JN439_RS18085	COG0488	(ABC) transporter
JN439_RS18095	COG2252	PERMEase
JN439_RS18100	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JN439_RS18105	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JN439_RS18110	COG3178	'Phosphotransferase
JN439_RS18115	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
JN439_RS18125	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
JN439_RS18130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JN439_RS18135	COG2967	ApaG domain
JN439_RS18140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JN439_RS18150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN439_RS18160	COG3314	Sporulation integral membrane protein YlbJ
JN439_RS18165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JN439_RS18170	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JN439_RS18175	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JN439_RS18180	COG0142	geranyltranstransferase activity
JN439_RS18185	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
JN439_RS18190	COG0330	HflC and HflK could
JN439_RS18195	COG0330	HflC and HflK could
JN439_RS18200	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JN439_RS18205	COG1923	regulation of RNA biosynthetic process
JN439_RS18210	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JN439_RS18215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JN439_RS18225	COG0802	atpase or kinase
JN439_RS18230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JN439_RS18230	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JN439_RS18250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JN439_RS18255	COG2011	ABC-type metal ion transport system permease component
JN439_RS18260	COG1464	Belongs to the NlpA lipoprotein family
JN439_RS18295	COG0784	Response regulator, receiver
JN439_RS18295	COG2198	Histidine kinase
JN439_RS18295	COG5002	protein histidine kinase activity
JN439_RS18315	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
JN439_RS18330	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JN439_RS18335	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
JN439_RS18340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JN439_RS18345	COG2716	regulation of RNA biosynthetic process
JN439_RS18350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JN439_RS18355	COG3013	Belongs to the UPF0304 family
JN439_RS18365	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JN439_RS18370	COG0280	phosphate acetyltransferase
JN439_RS18370	COG0857	belongs to the CobB CobQ family
JN439_RS18400	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JN439_RS18410	COG3077	Addiction module antitoxin, RelB DinJ family
JN439_RS18415	COG3385	transposase activity
JN439_RS18430	COG5489	Protein of unknown function (DUF736)
JN439_RS18460	COG1192	Involved in chromosome partitioning
JN439_RS18475	COG4959	Type IV secretory pathway protease TraF
JN439_RS18495	COG1127	ABC transporter
JN439_RS18500	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JN439_RS18560	COG3846	protein secretion by the type IV secretion system
JN439_RS18575	COG3451	type IV secretory pathway VirB4
JN439_RS18585	COG3838	Conjugal transfer protein Trbc
JN439_RS18590	COG4962	Type ii secretion system protein e
JN439_RS18620	COG2076	Multidrug Resistance protein
JN439_RS18640	COG2003	Belongs to the UPF0758 family
JN439_RS18645	COG4804	nuclease activity
JN439_RS18675	COG4962	Type ii secretion system protein e
JN439_RS18680	COG3838	Conjugal transfer protein Trbc
JN439_RS18690	COG3451	type IV secretory pathway VirB4
JN439_RS18730	COG0440	acetolactate synthase activity
JN439_RS18735	COG0028	Belongs to the TPP enzyme family
JN439_RS18750	COG0671	phosphoesterase, PA-phosphatase related
JN439_RS18760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JN439_RS18765	COG0473	3-isopropylmalate dehydrogenase activity
JN439_RS18770	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JN439_RS18775	COG0066	3-isopropylmalate dehydratase activity
JN439_RS18790	COG4143	(ABC) transporter
JN439_RS18795	COG1178	ABC-type Fe3 transport system permease component
JN439_RS18800	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
JN439_RS18810	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JN439_RS18820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JN439_RS18850	COG0316	Belongs to the HesB IscA family
JN439_RS18860	COG0038	chloride channel
JN439_RS18865	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JN439_RS18880	COG0671	phosphoesterase, PA-phosphatase related
JN439_RS18890	COG0583	DNA-binding transcription factor activity
JN439_RS18895	COG2076	Multidrug Resistance protein
JN439_RS18905	COG0346	lactoylglutathione lyase activity
JN439_RS18910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JN439_RS18915	COG1643	Atp-dependent helicase
JN439_RS18925	COG1489	DNA binding
JN439_RS18930	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JN439_RS18935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JN439_RS18945	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JN439_RS18950	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JN439_RS18955	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JN439_RS18965	COG0842	Transport permease protein
JN439_RS18970	COG1131	(ABC) transporter
JN439_RS18985	COG0163	prenyltransferase activity
JN439_RS18990	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JN439_RS18995	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JN439_RS19010	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
JN439_RS19025	COG1136	(ABC) transporter
JN439_RS19080	COG2801	Transposase and inactivated derivatives
JN439_RS19085	COG0529	Catalyzes the synthesis of activated sulfate
JN439_RS19090	COG3273	potassium ion transport
JN439_RS19090	COG0471	metal ion transport
JN439_RS19095	COG2895	sulfate adenylyltransferase (ATP) activity
JN439_RS19100	COG0175	sulfate reduction
JN439_RS19105	COG1648	precorrin-2 dehydrogenase activity
JN439_RS19105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JN439_RS19110	COG0330	HflC and HflK could
JN439_RS19115	COG1585	Membrane protein implicated in regulation of membrane protease activity
JN439_RS19125	COG0673	inositol 2-dehydrogenase activity
JN439_RS19135	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JN439_RS19140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JN439_RS19145	COG3036	rescue of stalled ribosome
JN439_RS19160	COG0138	bifunctional purine biosynthesis protein purh
JN439_RS19200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JN439_RS19205	COG0358	DNA primase activity
JN439_RS19210	COG1610	YqeY-like protein
JN439_RS19215	COG0828	Belongs to the bacterial ribosomal protein bS21 family
JN439_RS19220	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JN439_RS19230	COG1388	LysM domain
JN439_RS19230	COG4942	peptidase
JN439_RS19235	COG1238	metal cluster binding
JN439_RS19240	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JN439_RS19245	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
JN439_RS19250	COG0585	pseudouridine synthase activity
JN439_RS19260	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JN439_RS19265	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
JN439_RS19270	COG0148	phosphopyruvate hydratase activity
JN439_RS19275	COG0504	CTP synthase activity
JN439_RS19280	COG3956	TIGRFAM MazG family protein
JN439_RS19285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JN439_RS19290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JN439_RS19300	COG4807	Protein conserved in bacteria
JN439_RS19305	COG3023	N-Acetylmuramoyl-L-alanine amidase
JN439_RS19310	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
JN439_RS19315	COG1381	Involved in DNA repair and RecF pathway recombination
JN439_RS19325	COG0571	ribonuclease III activity
JN439_RS19330	COG0681	Belongs to the peptidase S26 family
JN439_RS19335	COG0481	GTPase activity
JN439_RS19350	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
JN439_RS19355	COG1595	DNA-templated transcription, initiation
JN439_RS19360	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JN439_RS19370	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
JN439_RS19380	COG0583	DNA-binding transcription factor activity
JN439_RS19410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JN439_RS19420	COG0126	phosphoglycerate kinase activity
JN439_RS19425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JN439_RS19430	COG1940	carbohydrate kinase activity
JN439_RS19435	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JN439_RS19445	COG4991	sh3 domain protein
JN439_RS19450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JN439_RS19465	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JN439_RS19470	COG1028	Short-chain dehydrogenase reductase Sdr
JN439_RS19480	COG1505	serine-type exopeptidase activity
JN439_RS19485	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JN439_RS19490	COG0765	amino acid transport
JN439_RS19495	COG0765	amino acid transport
JN439_RS19500	COG1126	abc transporter atp-binding protein
JN439_RS19505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JN439_RS19510	COG3174	membrane
JN439_RS19515	COG0110	maltose O-acetyltransferase activity
JN439_RS19545	COG1942	4-Oxalocrotonate Tautomerase
JN439_RS19555	COG0583	DNA-binding transcription factor activity
JN439_RS19560	COG0165	Argininosuccinate lyase
JN439_RS19565	COG0137	argininosuccinate synthase activity
JN439_RS19575	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JN439_RS19580	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JN439_RS19590	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
JN439_RS19595	COG3447	MASE1 domain protein
JN439_RS19595	COG5002	protein histidine kinase activity
JN439_RS19595	COG5001	Diguanylate cyclase
JN439_RS19600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JN439_RS19635	COG0583	DNA-binding transcription factor activity
JN439_RS19640	COG1380	Effector of murein hydrolase LrgA
JN439_RS19645	COG1346	cytolysis
JN439_RS19650	COG0527	aspartate kinase activity
JN439_RS19650	COG0460	homoserine dehydrogenase
JN439_RS19655	COG0626	cystathionine gamma-synthase activity
JN439_RS19670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JN439_RS19675	COG0814	amino acid
JN439_RS19680	COG1218	3'(2'),5'-bisphosphate nucleotidase
JN439_RS19685	COG0494	nUDIX hydrolase
JN439_RS19690	COG1011	Hydrolase
JN439_RS19695	COG1902	pentaerythritol trinitrate reductase activity
JN439_RS19705	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JN439_RS19720	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
JN439_RS19730	COG3156	type II secretion system protein K
JN439_RS19740	COG4795	General secretion pathway protein
JN439_RS19745	COG2165	general secretion pathway protein
JN439_RS19755	COG2165	general secretion pathway protein
JN439_RS19760	COG1459	type II secretion system
JN439_RS19765	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JN439_RS19775	COG3031	protein transport across the cell outer membrane
JN439_RS19785	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JN439_RS19790	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JN439_RS19810	COG3133	Outer membrane lipoprotein
JN439_RS19815	COG3025	triphosphatase activity
JN439_RS19820	COG1392	Phosphate transport regulator
JN439_RS19825	COG0306	phosphate transporter
JN439_RS19830	COG0617	tRNA 3'-terminal CCA addition
JN439_RS19835	COG3409	Peptidoglycan-binding domain 1 protein
JN439_RS19835	COG3267	Type II secretory pathway component ExeA
JN439_RS19845	COG1194	a g-specific adenine glycosylase
JN439_RS19850	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
JN439_RS19865	COG3240	lipase activity
JN439_RS19875	COG3009	Protein conserved in bacteria
JN439_RS19880	COG3008	intermembrane lipid transfer
JN439_RS19880	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JN439_RS19885	COG2995	paraquat-inducible protein a
JN439_RS19895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JN439_RS19900	COG5001	Diguanylate cyclase
JN439_RS19900	COG4251	negative regulation of phosphorylation
JN439_RS19900	COG3706	GGDEF domain
JN439_RS19900	COG2203	Gaf domain
JN439_RS19905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JN439_RS19910	COG2813	Specifically methylates the guanine in position
JN439_RS19915	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JN439_RS19920	COG0297	glycogen (starch) synthase activity
JN439_RS19955	COG1757	Na H antiporter
JN439_RS19960	COG0583	DNA-binding transcription factor activity
JN439_RS19965	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JN439_RS19970	COG3842	ATPase activity
JN439_RS19975	COG1176	ABC-type spermidine putrescine transport system, permease component I
JN439_RS19980	COG1177	transmembrane transport
JN439_RS19985	COG1012	belongs to the aldehyde dehydrogenase family
JN439_RS19990	COG0109	protoheme IX farnesyltransferase activity
JN439_RS20020	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
JN439_RS20030	COG1565	acr, cog1565
JN439_RS20030	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JN439_RS20035	COG1444	tRNA N-acetyltransferase activity
JN439_RS20055	COG1803	Methylglyoxal synthase
JN439_RS20070	COG0252	asparaginase activity
JN439_RS20090	COG1263	PTS System
JN439_RS20090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JN439_RS20095	COG0366	Alpha amylase catalytic
JN439_RS20100	COG0110	maltose O-acetyltransferase activity
JN439_RS20105	COG1522	sequence-specific DNA binding
JN439_RS20135	COG3068	Protein conserved in bacteria
JN439_RS20145	COG0739	heme binding
JN439_RS20165	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
JN439_RS20170	COG1121	(ABC) transporter
JN439_RS20175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JN439_RS20180	COG0583	DNA-binding transcription factor activity
JN439_RS20190	COG1573	uracil-dna glycosylase
JN439_RS20195	COG2962	Rard protein
JN439_RS20200	COG2827	Endonuclease containing a URI domain
JN439_RS20215	COG1842	Phage shock protein A
JN439_RS20220	COG0204	Acyl-transferase
JN439_RS20240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JN439_RS20250	COG0484	heat shock protein binding
JN439_RS20290	COG5433	transposase activity
JN439_RS20300	COG3039	Transposase
JN439_RS20330	COG1289	transmembrane transporter activity
JN439_RS20335	COG1566	PFAM secretion protein HlyD family protein
JN439_RS20350	COG1051	belongs to the nudix hydrolase family
JN439_RS20355	COG3150	esterase
JN439_RS20365	COG3151	Protein conserved in bacteria
JN439_RS20370	COG0494	nUDIX hydrolase
JN439_RS20375	COG1538	Outer membrane efflux protein
JN439_RS20385	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
JN439_RS20385	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JN439_RS20390	COG1560	Kdo2-lipid A biosynthetic process
JN439_RS20405	COG2771	luxR family
JN439_RS20410	COG3916	Acyl-homoserine-lactone synthase
JN439_RS20420	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
JN439_RS20425	COG2213	PTS system mannitol-specific
JN439_RS20425	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JN439_RS20430	COG0246	Mannitol dehydrogenase
JN439_RS20435	COG3722	fumarate hydratase activity
JN439_RS20440	COG3263	regulation of cellular component size
JN439_RS20460	COG1671	Belongs to the UPF0178 family
JN439_RS20475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JN439_RS20480	COG0513	Belongs to the DEAD box helicase family
JN439_RS20500	COG1575	Belongs to the MenA family. Type 1 subfamily
JN439_RS20505	COG1169	isochorismate synthase
JN439_RS20510	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JN439_RS20515	COG0596	Alpha beta hydrolase
JN439_RS20520	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JN439_RS20530	COG0318	PFAM AMP-dependent synthetase and ligase
JN439_RS20535	COG3291	Pkd domain containing protein
JN439_RS20540	COG2949	membrane
JN439_RS20545	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JN439_RS20555	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JN439_RS20585	COG2873	o-acetylhomoserine
JN439_RS20595	COG1979	alcohol dehydrogenase
JN439_RS20610	COG4221	oxidoreductase activity
JN439_RS20630	COG1285	pathogenesis
JN439_RS20645	COG1368	sulfuric ester hydrolase activity
JN439_RS20650	COG1522	sequence-specific DNA binding
JN439_RS20660	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
JN439_RS20670	COG1058	Belongs to the CinA family
JN439_RS20670	COG1546	Belongs to the CinA family
JN439_RS20675	COG1988	membrane-bound metal-dependent
JN439_RS20685	COG0561	phosphatase activity
JN439_RS20690	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JN439_RS20700	COG1011	Hydrolase
JN439_RS20715	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JN439_RS20720	COG0019	diaminopimelate decarboxylase activity
JN439_RS20730	COG1965	Belongs to the frataxin family
JN439_RS20735	COG0400	carboxylic ester hydrolase activity
JN439_RS20740	COG3072	Adenylate cyclase
JN439_RS20745	COG0181	hydroxymethylbilane synthase activity
JN439_RS20755	COG2959	enzyme of heme biosynthesis
JN439_RS20760	COG3071	HemY protein
JN439_RS20765	COG0312	modulator of DNA gyrase
JN439_RS20770	COG3028	Belongs to the UPF0307 family
JN439_RS20780	COG2926	Belongs to the UPF0265 family
JN439_RS20815	COG1396	sequence-specific DNA binding
JN439_RS20820	COG3135	benzoate transporter
JN439_RS20850	COG3047	cAMP biosynthetic process
JN439_RS20855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JN439_RS20860	COG2197	response regulator
JN439_RS20890	COG5642	Protein of unknown function (DUF2384)
JN439_RS20910	COG3328	transposase activity
JN439_RS20915	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JN439_RS20965	COG0457	Tetratricopeptide repeat
JN439_RS20970	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
JN439_RS20975	COG1215	transferase activity, transferring glycosyl groups
JN439_RS21005	COG5499	transcription regulator containing HTH domain
JN439_RS21010	COG2916	Histone family protein nucleoid-structuring protein H-NS
JN439_RS21020	COG3039	Transposase
JN439_RS21080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JN439_RS21085	COG5642	Protein of unknown function (DUF2384)
JN439_RS21100	COG1484	DNA-dependent DNA replication
JN439_RS21105	COG4584	PFAM Integrase catalytic
JN439_RS21115	COG5499	transcription regulator containing HTH domain
JN439_RS21185	COG2850	peptidyl-arginine hydroxylation
JN439_RS21190	COG5642	Protein of unknown function (DUF2384)
JN439_RS21210	COG2916	Histone family protein nucleoid-structuring protein H-NS
JN439_RS21290	COG1396	sequence-specific DNA binding
JN439_RS21310	COG1278	Cold shock
JN439_RS21340	COG3706	GGDEF domain
JN439_RS21345	COG0347	Belongs to the P(II) protein family
JN439_RS21350	COG0004	ammonium transporteR
JN439_RS21385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JN439_RS21390	COG1074	ATP-dependent DNA helicase activity
JN439_RS21395	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
JN439_RS21400	COG2259	Doxx family
JN439_RS21405	COG1741	Belongs to the pirin family
JN439_RS21415	COG0583	DNA-binding transcription factor activity
JN439_RS21440	COG1175	transmembrane transport
JN439_RS21450	COG3842	ATPase activity
JN439_RS21480	COG0456	acetyltransferase
JN439_RS21485	COG0753	catalase activity
JN439_RS21505	COG0494	nUDIX hydrolase
JN439_RS21510	COG0628	permease
JN439_RS21520	COG2957	Belongs to the agmatine deiminase family
JN439_RS21535	COG2957	Belongs to the agmatine deiminase family
JN439_RS21540	COG0583	DNA-binding transcription factor activity
JN439_RS21555	COG1461	Dihydroxyacetone kinase
JN439_RS21560	COG2376	Dihydroxyacetone kinase
JN439_RS21565	COG2252	PERMEase
JN439_RS21570	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
JN439_RS21605	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JN439_RS21610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JN439_RS21615	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JN439_RS21620	COG0049	tRNA binding
JN439_RS21625	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JN439_RS21630	COG2168	tRNA wobble position uridine thiolation
JN439_RS21640	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
JN439_RS21645	COG0251	oxidation-reduction process
JN439_RS21650	COG2964	Protein conserved in bacteria
JN439_RS21655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JN439_RS21660	COG0085	RNA polymerase activity
JN439_RS21665	COG0222	ribosome binding
JN439_RS21670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JN439_RS21675	COG0081	regulation of translation
JN439_RS21680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JN439_RS21685	COG0250	Participates in transcription elongation, termination and antitermination
JN439_RS21700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JN439_RS21725	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JN439_RS21730	COG0569	domain protein
JN439_RS21735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JN439_RS21740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JN439_RS21745	COG3005	denitrification pathway
JN439_RS21750	COG0243	molybdopterin cofactor binding
JN439_RS21785	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JN439_RS21795	COG2204	response regulator
JN439_RS21805	COG2205	protein histidine kinase activity
JN439_RS21825	COG0517	IMP dehydrogenase activity
JN439_RS21825	COG0516	GMP reductase activity
JN439_RS21835	COG1522	sequence-specific DNA binding
JN439_RS21840	COG2502	aspartate--ammonia ligase
JN439_RS21855	COG0583	DNA-binding transcription factor activity
JN439_RS21860	COG0542	response to heat
JN439_RS21870	COG0564	pseudouridine synthase activity
JN439_RS21875	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JN439_RS21880	COG3681	Belongs to the UPF0597 family
JN439_RS21885	COG2964	Protein conserved in bacteria
JN439_RS21890	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
JN439_RS21895	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
JN439_RS21900	COG1979	alcohol dehydrogenase
JN439_RS21905	COG2207	Transcriptional regulator
JN439_RS21910	COG3040	lipid binding
JN439_RS21930	COG0583	DNA-binding transcription factor activity
JN439_RS21950	COG0540	Belongs to the ATCase OTCase family
JN439_RS21955	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
JN439_RS21960	COG1438	arginine binding
JN439_RS21965	COG1288	antiporter activity
JN439_RS21970	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JN439_RS22010	COG3250	beta-galactosidase activity
JN439_RS22015	COG1609	Transcriptional regulator
JN439_RS22020	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JN439_RS22030	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JN439_RS22035	COG2017	converts alpha-aldose to the beta-anomer
JN439_RS22040	COG0667	Aldo Keto reductase
JN439_RS22045	COG1968	undecaprenyl-diphosphatase activity
JN439_RS22050	COG3806	Anti-sigma factor
JN439_RS22055	COG1595	DNA-templated transcription, initiation
JN439_RS22075	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JN439_RS22080	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JN439_RS22085	COG0477	Major facilitator Superfamily
JN439_RS22100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JN439_RS22105	COG1131	(ABC) transporter
JN439_RS22110	COG0842	Transport permease protein
JN439_RS22115	COG0842	Transport permease protein
JN439_RS22120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JN439_RS22130	COG2116	formate transmembrane transporter activity
JN439_RS22135	COG1648	precorrin-2 dehydrogenase activity
JN439_RS22135	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JN439_RS22140	COG2239	Acts as a magnesium transporter
JN439_RS22145	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JN439_RS22155	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JN439_RS22165	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
JN439_RS22175	COG0514	ATP-dependent DNA helicase (RecQ)
JN439_RS22180	COG2050	protein possibly involved in aromatic compounds catabolism
JN439_RS22195	COG2258	MOSC domain
JN439_RS22200	COG1177	transmembrane transport
JN439_RS22205	COG1176	ABC-type spermidine putrescine transport system, permease component I
JN439_RS22210	COG3842	ATPase activity
JN439_RS22230	COG0174	glutamine synthetase
JN439_RS22250	COG3045	CreA protein
JN439_RS22255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JN439_RS22260	COG0443	Heat shock 70 kDa protein
JN439_RS22275	COG0366	Alpha amylase catalytic
JN439_RS22290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JN439_RS22295	COG0745	RESPONSE REGULATOR receiver
JN439_RS22305	COG2205	protein histidine kinase activity
JN439_RS22315	COG0281	malic enzyme
JN439_RS22320	COG0702	epimerase
JN439_RS22325	COG0254	rRNA binding
JN439_RS22330	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JN439_RS22355	COG0129	dihydroxy-acid dehydratase activity
JN439_RS22365	COG3978	acetolactate synthase activity
JN439_RS22375	COG0606	chelatase, subunit chli
JN439_RS22380	COG0204	Acyl-transferase
JN439_RS22385	COG0204	Acyl-transferase
JN439_RS22390	COG1683	Conserved Protein
JN439_RS22400	COG1335	isochorismatase
JN439_RS22410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JN439_RS22415	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JN439_RS22425	COG3084	Protein conserved in bacteria
JN439_RS22430	COG5001	Diguanylate cyclase
JN439_RS22430	COG2203	Gaf domain
JN439_RS22430	COG4251	negative regulation of phosphorylation
JN439_RS22430	COG3706	GGDEF domain
JN439_RS22445	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JN439_RS22450	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JN439_RS22455	COG1561	YicC-like family, N-terminal region
JN439_RS22465	COG1519	Transferase
JN439_RS22470	COG0859	PFAM glycosyl transferase family 9
JN439_RS22475	COG0463	Glycosyl transferase, family 2
JN439_RS22480	COG0859	PFAM glycosyl transferase family 9
JN439_RS22485	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JN439_RS22490	COG2990	Protein conserved in bacteria
JN439_RS22495	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JN439_RS22505	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JN439_RS22510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JN439_RS22515	COG2003	Belongs to the UPF0758 family
JN439_RS22520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JN439_RS22525	COG0756	dUTP diphosphatase activity
JN439_RS22530	COG1309	transcriptional regulator
JN439_RS22540	COG0668	transmembrane transport
JN439_RS22550	COG0166	Belongs to the GPI family
JN439_RS22555	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JN439_RS22560	COG0583	DNA-binding transcription factor activity
JN439_RS22570	COG1042	CoA-binding domain protein
JN439_RS22570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JN439_RS22570	COG0045	succinate-CoA ligase (ADP-forming) activity
JN439_RS22595	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
JN439_RS22600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JN439_RS22605	COG1739	Uncharacterized protein family UPF0029
JN439_RS22610	COG0006	proline dipeptidase activity
JN439_RS22615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JN439_RS22620	COG1250	3-hydroxyacyl-CoA dehydrogenase
JN439_RS22620	COG1024	Enoyl-CoA hydratase
JN439_RS22625	COG0183	Belongs to the thiolase family
JN439_RS22660	COG0425	Belongs to the sulfur carrier protein TusA family
JN439_RS22665	COG0251	oxidation-reduction process
JN439_RS22685	COG2885	chlorophyll binding
JN439_RS22695	COG1335	isochorismatase
JN439_RS22700	COG2818	Glycosylase
JN439_RS22705	COG0752	glycyl-tRNA synthetase alpha subunit
JN439_RS22710	COG0751	glycine-tRNA ligase activity
JN439_RS22725	COG4251	negative regulation of phosphorylation
JN439_RS22725	COG2203	Gaf domain
JN439_RS22725	COG5001	Diguanylate cyclase
JN439_RS22725	COG3706	GGDEF domain
JN439_RS22745	COG0814	amino acid
JN439_RS22750	COG0814	amino acid
JN439_RS22755	COG3033	Beta-eliminating lyase
JN439_RS22765	COG0348	domain, Protein
JN439_RS22775	COG0446	pyridine nucleotide-disulphide oxidoreductase
JN439_RS22780	COG0426	domain, Protein
JN439_RS22780	COG1773	rubredoxin
JN439_RS22785	COG3604	Transcriptional regulator
JN439_RS22790	COG1609	Transcriptional regulator
JN439_RS22830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JN439_RS22850	COG2960	long-chain fatty acid transporting porin activity
JN439_RS22860	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JN439_RS22875	COG3118	belongs to the thioredoxin family
JN439_RS22880	COG0513	Belongs to the DEAD box helicase family
JN439_RS22885	COG0248	Ppx GppA phosphatase
JN439_RS22895	COG0742	ribosomal rna small subunit methyltransferase
JN439_RS22915	COG0084	hydrolase, TatD family'
JN439_RS22920	COG0805	protein transport
JN439_RS22925	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JN439_RS22930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JN439_RS22935	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JN439_RS22940	COG3165	ubiquinone biosynthetic process from chorismate
JN439_RS22950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JN439_RS22955	COG0402	S-adenosylhomocysteine deaminase activity
JN439_RS22995	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
JN439_RS23000	COG0848	biopolymer transport protein
JN439_RS23005	COG0811	peptide transport
JN439_RS23010	COG0811	peptide transport
JN439_RS23020	COG2771	luxR family
JN439_RS23070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JN439_RS23075	COG0443	Heat shock 70 kDa protein
JN439_RS23115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JN439_RS23120	COG1349	DNA-binding transcription factor activity
JN439_RS23125	COG0745	RESPONSE REGULATOR receiver
JN439_RS23130	COG2205	protein histidine kinase activity
JN439_RS23140	COG4452	Inner membrane protein CreD
JN439_RS23145	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JN439_RS23150	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JN439_RS23155	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JN439_RS23160	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JN439_RS23165	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JN439_RS23170	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JN439_RS23175	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JN439_RS23185	COG0356	it plays a direct role in the translocation of protons across the membrane
JN439_RS23195	COG1475	DNA binding
JN439_RS23200	COG1192	Involved in chromosome partitioning
JN439_RS23205	COG0357	Ribosomal RNA small subunit methyltransferase G
JN439_RS23210	COG0445	tRNA wobble uridine modification
JN439_RS23215	COG0716	FMN binding
JN439_RS23220	COG4774	siderophore transport
JN439_RS23225	COG4615	Cyclic peptide transporter
JN439_RS23230	COG1120	ATPase activity
JN439_RS23235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JN439_RS23245	COG3550	peptidyl-serine autophosphorylation
JN439_RS23270	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JN439_RS23275	COG0706	membrane insertase activity
JN439_RS23280	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JN439_RS23285	COG0594	ribonuclease P activity
JN439_RS23290	COG0230	Belongs to the bacterial ribosomal protein bL34 family
JN439_RS23295	COG1126	abc transporter atp-binding protein
JN439_RS23325	COG1192	Involved in chromosome partitioning
JN439_RS23365	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JN439_RS23405	COG0419	ATPase involved in DNA repair
JN439_RS23430	COG3550	peptidyl-serine autophosphorylation
JN439_RS23520	COG0776	regulation of translation
JN439_RS23540	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JN439_RS23620	COG1192	Involved in chromosome partitioning
JN439_RS23650	COG0358	DNA primase activity
JN439_RS23670	COG1923	regulation of RNA biosynthetic process
JN439_RS23695	COG5301	cellulose 1,4-beta-cellobiosidase activity
JN439_RS23845	COG0556	nucleotide-excision repair
JN439_RS23880	COG3039	Transposase
JN439_RS23900	COG4974	Belongs to the 'phage' integrase family
JN439_RS24070	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JN439_RS24085	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JN439_RS24125	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JN439_RS24180	COG2948	multi-organism process
JN439_RS24190	COG3504	Conjugal transfer protein
JN439_RS24200	COG3451	type IV secretory pathway VirB4
JN439_RS24210	COG3838	Conjugal transfer protein Trbc
JN439_RS24215	COG4962	Type ii secretion system protein e
JN439_RS24230	COG3041	Addiction module toxin RelE StbE family
JN439_RS24235	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JN439_RS24250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JN439_RS24280	COG1192	Involved in chromosome partitioning
JN439_RS24290	COG0840	transmembrane signaling receptor activity
JN439_RS24305	COG1192	Involved in chromosome partitioning
JN439_RS24340	COG2176	DNA-directed DNA polymerase activity
JN439_RS24340	COG5002	protein histidine kinase activity
JN439_RS24385	COG0840	transmembrane signaling receptor activity