locus-tag	class	description
L6426_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L6426_RS00010	COG0592	DNA-directed DNA polymerase activity
L6426_RS00020	COG0187	DNA topoisomerase II activity
L6426_RS00025	COG2207	Transcriptional regulator
L6426_RS00030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L6426_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
L6426_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
L6426_RS00045	COG3977	Valine--pyruvate aminotransferase
L6426_RS00060	COG2814	Major facilitator Superfamily
L6426_RS00065	COG0745	RESPONSE REGULATOR receiver
L6426_RS00070	COG2205	protein histidine kinase activity
L6426_RS00105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L6426_RS00110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6426_RS00110	COG4191	Histidine kinase
L6426_RS00115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6426_RS00120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6426_RS00125	COG1309	transcriptional regulator
L6426_RS00155	COG0561	phosphatase activity
L6426_RS00160	COG2267	carboxylic ester hydrolase activity
L6426_RS00165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L6426_RS00170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L6426_RS00175	COG1758	RNA polymerase activity
L6426_RS00185	COG0859	PFAM glycosyl transferase family 9
L6426_RS00190	COG3642	lipopolysaccharide core region biosynthetic process
L6426_RS00230	COG0589	response to stress
L6426_RS00235	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L6426_RS00240	COG3706	GGDEF domain
L6426_RS00245	COG1528	Iron-storage protein
L6426_RS00250	COG2081	HI0933 family
L6426_RS00305	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L6426_RS00325	COG4584	PFAM Integrase catalytic
L6426_RS00335	COG2223	nitrite transmembrane transporter activity
L6426_RS00340	COG1280	lysine exporter protein (LysE YggA)
L6426_RS00355	COG3188	usher protein
L6426_RS00375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6426_RS00375	COG2205	protein histidine kinase activity
L6426_RS00385	COG3275	phosphorelay sensor kinase activity
L6426_RS00390	COG3279	Response regulator of the LytR AlgR family
L6426_RS00395	COG2223	nitrite transmembrane transporter activity
L6426_RS00400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L6426_RS00405	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L6426_RS00450	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L6426_RS00455	COG2166	iron-sulfur cluster assembly
L6426_RS00460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L6426_RS00480	COG1063	alcohol dehydrogenase
L6426_RS00485	COG0156	8-amino-7-oxononanoate synthase activity
L6426_RS00495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6426_RS00540	COG1609	Transcriptional regulator
L6426_RS00555	COG1580	Controls the rotational direction of flagella during chemotaxis
L6426_RS00560	COG3161	chorismate lyase activity
L6426_RS00565	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L6426_RS00570	COG2937	Belongs to the GPAT DAPAT family
L6426_RS00575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L6426_RS00590	COG0534	Mate efflux family protein
L6426_RS00595	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L6426_RS00600	COG2205	protein histidine kinase activity
L6426_RS00605	COG0745	RESPONSE REGULATOR receiver
L6426_RS00615	COG1045	serine acetyltransferase
L6426_RS00625	COG3074	FtsZ-dependent cytokinesis
L6426_RS00630	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
L6426_RS00635	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6426_RS00635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6426_RS00640	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L6426_RS00680	COG1609	Transcriptional regulator
L6426_RS00685	COG3250	beta-galactosidase activity
L6426_RS00690	COG2731	YhcH YjgK YiaL family protein
L6426_RS00695	COG0531	amino acid
L6426_RS00700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6426_RS00705	COG0531	amino acid
L6426_RS00710	COG0385	Bile acid
L6426_RS00715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L6426_RS00740	COG0583	DNA-binding transcription factor activity
L6426_RS00745	COG1079	Belongs to the binding-protein-dependent transport system permease family
L6426_RS00750	COG4603	Belongs to the binding-protein-dependent transport system permease family
L6426_RS00755	COG3845	ABC transporter
L6426_RS00760	COG1744	ABC transporter substrate-binding protein PnrA-like
L6426_RS00765	COG0210	DNA helicase
L6426_RS00775	COG1943	Transposase
L6426_RS00780	COG0583	DNA-binding transcription factor activity
L6426_RS00815	COG0583	DNA-binding transcription factor activity
L6426_RS00830	COG1280	lysine exporter protein (LysE YggA)
L6426_RS00840	COG2962	Rard protein
L6426_RS00850	COG1012	belongs to the aldehyde dehydrogenase family
L6426_RS00855	COG1396	sequence-specific DNA binding
L6426_RS00860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6426_RS00870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L6426_RS00870	COG0519	Catalyzes the synthesis of GMP from XMP
L6426_RS00880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6426_RS00900	COG1322	Protein conserved in bacteria
L6426_RS00905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6426_RS00910	COG0569	domain protein
L6426_RS00915	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L6426_RS00915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L6426_RS00920	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L6426_RS00925	COG0242	peptide deformylase activity
L6426_RS00935	COG0758	DNA mediated transformation
L6426_RS00940	COG2922	Belongs to the Smg family
L6426_RS00945	COG0551	DNA topoisomerase type I activity
L6426_RS00950	COG0009	L-threonylcarbamoyladenylate synthase
L6426_RS00955	COG0408	coproporphyrinogen oxidase activity
L6426_RS00960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L6426_RS00965	COG0218	Necessary for normal cell division and for the maintenance of normal septation
L6426_RS00975	COG3078	GTPase activator activity
L6426_RS00985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L6426_RS00990	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L6426_RS01000	COG3852	Histidine kinase
L6426_RS01010	COG0174	glutamine synthetase
L6426_RS01015	COG1217	gtp-binding protein TYPA
L6426_RS01020	COG1295	ribonuclease BN
L6426_RS01025	COG1490	D-aminoacyl-tRNA deacylase activity
L6426_RS01035	COG0456	acetyltransferase
L6426_RS01045	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L6426_RS01050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6426_RS01055	COG2610	gluconate transmembrane transporter activity
L6426_RS01060	COG3265	gluconokinase activity
L6426_RS01065	COG0129	dihydroxy-acid dehydratase activity
L6426_RS01070	COG0800	Aldolase
L6426_RS01085	COG1609	Transcriptional regulator
L6426_RS01095	COG4942	peptidase
L6426_RS01100	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L6426_RS01105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6426_RS01110	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
L6426_RS01115	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L6426_RS01120	COG0316	Belongs to the HesB IscA family
L6426_RS01120	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
L6426_RS01125	COG1040	competence protein
L6426_RS01130	COG0596	Alpha beta hydrolase
L6426_RS01145	COG2183	response to ionizing radiation
L6426_RS01150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L6426_RS01160	COG2205	protein histidine kinase activity
L6426_RS01170	COG0051	transcription antitermination factor activity, RNA binding
L6426_RS01175	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L6426_RS01180	COG0088	Forms part of the polypeptide exit tunnel
L6426_RS01185	COG0089	rRNA binding
L6426_RS01190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L6426_RS01195	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L6426_RS01200	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L6426_RS01205	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L6426_RS01210	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L6426_RS01215	COG0255	Belongs to the universal ribosomal protein uL29 family
L6426_RS01220	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L6426_RS01225	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L6426_RS01230	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L6426_RS01235	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L6426_RS01240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L6426_RS01245	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L6426_RS01250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L6426_RS01255	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
L6426_RS01260	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L6426_RS01265	COG1841	ribosomal large subunit assembly
L6426_RS01270	COG0200	Binds to the 23S rRNA
L6426_RS01275	COG0201	protein transport
L6426_RS01280	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L6426_RS01285	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L6426_RS01290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L6426_RS01295	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L6426_RS01300	COG0202	RNA polymerase activity
L6426_RS01305	COG0203	ribosomal protein L17
L6426_RS01355	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6426_RS01360	COG0583	DNA-binding transcription factor activity
L6426_RS01365	COG4221	oxidoreductase activity
L6426_RS01380	COG1770	oligopeptidase
L6426_RS01385	COG2358	TRAP transporter, solute receptor (TAXI family
L6426_RS01400	COG3714	YhhN family
L6426_RS01415	COG0583	DNA-binding transcription factor activity
L6426_RS01425	COG1301	dicarboxylic acid transport
L6426_RS01435	COG2095	MarC family integral membrane protein
L6426_RS01445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L6426_RS01455	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
L6426_RS01465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6426_RS01490	COG0742	ribosomal rna small subunit methyltransferase
L6426_RS01495	COG0552	protein localization to endoplasmic reticulum
L6426_RS01500	COG2884	Cell division ATP-binding protein ftsE
L6426_RS01505	COG2177	Part of the ABC transporter FtsEX involved in
L6426_RS01515	COG0288	reversible hydration of carbon dioxide
L6426_RS01520	COG2188	Transcriptional regulator
L6426_RS01525	COG1228	amidohydrolase
L6426_RS01530	COG0010	Belongs to the arginase family
L6426_RS01535	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
L6426_RS01540	COG2986	histidine ammonia-lyase
L6426_RS01545	COG0387	Pfam Sodium calcium exchanger
L6426_RS01550	COG2200	EAL domain
L6426_RS01600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L6426_RS01605	COG1459	type II secretion system
L6426_RS01650	COG1077	Cell shape determining protein MreB Mrl
L6426_RS01655	COG1792	Involved in formation and maintenance of cell shape
L6426_RS01660	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L6426_RS01665	COG0424	maF-like protein
L6426_RS01670	COG1530	ribonuclease E activity
L6426_RS01675	COG3164	Protein of unknown function
L6426_RS01680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L6426_RS01685	COG0312	modulator of DNA gyrase
L6426_RS01700	COG0477	Major facilitator Superfamily
L6426_RS01710	COG2321	neutral zinc metallopeptidase
L6426_RS01745	COG0189	ligase activity
L6426_RS01750	COG0642	Histidine kinase
L6426_RS01755	COG0745	RESPONSE REGULATOR receiver
L6426_RS01770	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
L6426_RS01775	COG0352	thiamine-phosphate diphosphorylase activity
L6426_RS01780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6426_RS01790	COG2022	thiamine diphosphate biosynthetic process
L6426_RS01795	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L6426_RS01815	COG0110	maltose O-acetyltransferase activity
L6426_RS01830	COG3932	Exopolysaccharide synthesis, ExoD
L6426_RS01845	COG1733	regulation of RNA biosynthetic process
L6426_RS01870	COG2226	methyltransferase
L6426_RS01880	COG1494	fructose-1,6-bisphosphatase
L6426_RS01890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L6426_RS01895	COG5007	Belongs to the BolA IbaG family
L6426_RS01905	COG2854	intermembrane phospholipid transfer
L6426_RS01910	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L6426_RS01915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L6426_RS01920	COG1127	ABC transporter
L6426_RS01925	COG0517	IMP dehydrogenase activity
L6426_RS01925	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L6426_RS01930	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L6426_RS01940	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L6426_RS01945	COG1137	ATPase activity
L6426_RS01950	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
L6426_RS01960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6426_RS01965	COG1660	Displays ATPase and GTPase activities
L6426_RS01970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6426_RS01990	COG3964	amidohydrolase
L6426_RS02020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6426_RS02025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6426_RS02035	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L6426_RS02040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L6426_RS02045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L6426_RS02050	COG0723	plastoquinol--plastocyanin reductase activity
L6426_RS02055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L6426_RS02060	COG2857	Cytochrome c1
L6426_RS02065	COG0625	glutathione transferase activity
L6426_RS02070	COG2969	positive regulation of protein catabolic process
L6426_RS02075	COG2823	Periplasmic or secreted lipoprotein
L6426_RS02080	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L6426_RS02085	COG0792	nuclease activity
L6426_RS02090	COG3107	peptidoglycan biosynthetic process
L6426_RS02095	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
L6426_RS02105	COG2001	Belongs to the MraZ family
L6426_RS02110	COG0275	rRNA processing
L6426_RS02115	COG3116	cell division
L6426_RS02120	COG0768	penicillin binding
L6426_RS02125	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L6426_RS02130	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L6426_RS02135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L6426_RS02140	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L6426_RS02145	COG0772	Belongs to the SEDS family
L6426_RS02150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L6426_RS02155	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L6426_RS02160	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L6426_RS02165	COG0849	cell division
L6426_RS02170	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L6426_RS02175	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
L6426_RS02185	COG0653	protein targeting
L6426_RS02195	COG0494	nUDIX hydrolase
L6426_RS02200	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L6426_RS02205	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
L6426_RS02220	COG1459	type II secretion system
L6426_RS02225	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L6426_RS02250	COG2186	Transcriptional regulator
L6426_RS02255	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
L6426_RS02260	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6426_RS02265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L6426_RS02275	COG0840	transmembrane signaling receptor activity
L6426_RS02280	COG0840	transmembrane signaling receptor activity
L6426_RS02285	COG1752	Esterase of the alpha-beta hydrolase superfamily
L6426_RS02290	COG1049	propionate catabolic process, 2-methylcitrate cycle
L6426_RS02305	COG1280	lysine exporter protein (LysE YggA)
L6426_RS02315	COG0523	cobalamin synthesis protein
L6426_RS02320	COG0477	Major facilitator Superfamily
L6426_RS02335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L6426_RS02340	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L6426_RS02390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L6426_RS02415	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L6426_RS02420	COG0732	type I restriction modification DNA specificity domain
L6426_RS02425	COG1401	restriction endodeoxyribonuclease activity
L6426_RS02425	COG1401	restriction endodeoxyribonuclease activity
L6426_RS02435	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L6426_RS02470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L6426_RS02485	COG1546	Belongs to the CinA family
L6426_RS02490	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L6426_RS02495	COG2137	regulation of response to DNA damage stimulus
L6426_RS02500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L6426_RS02505	COG0527	aspartate kinase activity
L6426_RS02510	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
L6426_RS02545	COG1686	Belongs to the peptidase S11 family
L6426_RS02550	COG0586	Pfam SNARE associated Golgi protein
L6426_RS02555	COG1253	flavin adenine dinucleotide binding
L6426_RS02560	COG0525	valine-tRNA ligase activity
L6426_RS02565	COG2927	DNA polymerase III (CHI subunit)
L6426_RS02570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L6426_RS02575	COG0795	lipopolysaccharide-transporting ATPase activity
L6426_RS02580	COG0795	lipopolysaccharide-transporting ATPase activity
L6426_RS02600	COG0004	ammonium transporteR
L6426_RS02605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L6426_RS02620	COG2165	general secretion pathway protein
L6426_RS02625	COG0084	hydrolase, TatD family'
L6426_RS02630	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6426_RS02640	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
L6426_RS02645	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
L6426_RS02650	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
L6426_RS02655	COG0813	purine-nucleoside phosphorylase activity
L6426_RS02660	COG5002	protein histidine kinase activity
L6426_RS02660	COG3447	MASE1 domain protein
L6426_RS02660	COG5001	Diguanylate cyclase
L6426_RS02670	COG0560	Phosphoserine phosphatase
L6426_RS02685	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L6426_RS02695	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
L6426_RS02700	COG0776	regulation of translation
L6426_RS02715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L6426_RS02720	COG0735	belongs to the Fur family
L6426_RS02740	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
L6426_RS02745	COG0513	Belongs to the DEAD box helicase family
L6426_RS02750	COG3022	response to hydroperoxide
L6426_RS02765	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L6426_RS02770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6426_RS02775	COG0762	integral membrane protein
L6426_RS02780	COG1872	DUF167
L6426_RS02800	COG3112	Uncharacterised protein family (UPF0231)
L6426_RS02805	COG3835	regulator
L6426_RS02810	COG2610	gluconate transmembrane transporter activity
L6426_RS02815	COG1929	Belongs to the glycerate kinase type-1 family
L6426_RS02830	COG0583	DNA-binding transcription factor activity
L6426_RS02835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6426_RS02850	COG0347	Belongs to the P(II) protein family
L6426_RS02855	COG1840	ABC-type Fe3 transport system, periplasmic component
L6426_RS02865	COG3842	ATPase activity
L6426_RS02870	COG2837	iron assimilation
L6426_RS02875	COG1438	arginine binding
L6426_RS02880	COG1126	abc transporter atp-binding protein
L6426_RS02885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6426_RS02890	COG4215	(ABC) transporter
L6426_RS02895	COG4160	amino acid transport
L6426_RS02900	COG0039	L-malate dehydrogenase activity
L6426_RS02905	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
L6426_RS02910	COG1017	nitric oxide dioxygenase activity
L6426_RS02910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L6426_RS02920	COG4536	flavin adenine dinucleotide binding
L6426_RS02925	COG4137	Cytochrome C assembly protein
L6426_RS02930	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L6426_RS02935	COG0228	four-way junction DNA binding
L6426_RS02940	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L6426_RS02945	COG0336	Belongs to the RNA methyltransferase TrmD family
L6426_RS02950	COG0335	large ribosomal subunit rRNA binding
L6426_RS02965	COG1051	belongs to the nudix hydrolase family
L6426_RS02975	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L6426_RS02980	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
L6426_RS02985	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L6426_RS03035	COG5301	cellulose 1,4-beta-cellobiosidase activity
L6426_RS03135	COG4695	Portal protein
L6426_RS03255	COG4974	Belongs to the 'phage' integrase family
L6426_RS03260	COG0583	DNA-binding transcription factor activity
L6426_RS03265	COG0640	Transcriptional regulator
L6426_RS03270	COG0268	Binds directly to 16S ribosomal RNA
L6426_RS03275	COG0728	peptidoglycan biosynthetic process
L6426_RS03280	COG0196	riboflavin kinase activity
L6426_RS03285	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L6426_RS03290	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L6426_RS03295	COG1047	Peptidyl-prolyl cis-trans
L6426_RS03300	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L6426_RS03340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L6426_RS03340	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L6426_RS03355	COG1854	S-ribosylhomocysteine lyase activity
L6426_RS03360	COG3706	GGDEF domain
L6426_RS03365	COG0557	exoribonuclease II activity
L6426_RS03370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L6426_RS03380	COG2153	protein acetylation
L6426_RS03390	COG1914	H( )-stimulated, divalent metal cation uptake system
L6426_RS03395	COG0360	Binds together with S18 to 16S ribosomal RNA
L6426_RS03400	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L6426_RS03405	COG0359	binds to the 23S rRNA
L6426_RS03445	COG1238	metal cluster binding
L6426_RS03450	COG0612	Peptidase, M16
L6426_RS03455	COG2918	glutathione biosynthetic process
L6426_RS03460	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
L6426_RS03465	COG1027	Aspartate ammonia-lyase
L6426_RS03470	COG3030	protein affecting phage T7 exclusion by the F plasmid
L6426_RS03475	COG0534	Mate efflux family protein
L6426_RS03480	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L6426_RS03485	COG0459	protein refolding
L6426_RS03505	COG0564	pseudouridine synthase activity
L6426_RS03510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L6426_RS03545	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L6426_RS03555	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L6426_RS03560	COG4208	sulfate ABC transporter
L6426_RS03565	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L6426_RS03570	COG0583	DNA-binding transcription factor activity
L6426_RS03575	COG3397	chitin binding
L6426_RS03580	COG0840	transmembrane signaling receptor activity
L6426_RS03605	COG1328	CTP reductase activity
L6426_RS03610	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L6426_RS03625	COG1448	Aminotransferase
L6426_RS03630	COG2194	sulfuric ester hydrolase activity
L6426_RS03650	COG1215	transferase activity, transferring glycosyl groups
L6426_RS03655	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
L6426_RS03660	COG0457	Tetratricopeptide repeat
L6426_RS03660	COG3118	belongs to the thioredoxin family
L6426_RS03665	COG0457	Tetratricopeptide repeat
L6426_RS03665	COG3118	belongs to the thioredoxin family
L6426_RS03705	COG2015	COG2015, Alkyl sulfatase and related hydrolases
L6426_RS03710	COG0513	Belongs to the DEAD box helicase family
L6426_RS03715	COG0840	transmembrane signaling receptor activity
L6426_RS03725	COG4166	transmembrane transport
L6426_RS03740	COG1024	Enoyl-CoA hydratase
L6426_RS03755	COG4221	oxidoreductase activity
L6426_RS03760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L6426_RS03765	COG0442	prolyl-tRNA aminoacylation
L6426_RS03770	COG0840	transmembrane signaling receptor activity
L6426_RS03775	COG0632	four-way junction helicase activity
L6426_RS03780	COG2255	four-way junction helicase activity
L6426_RS03790	COG1271	oxidase subunit
L6426_RS03795	COG1294	oxidase, subunit
L6426_RS03800	COG4890	Cyd operon protein YbgT
L6426_RS03805	COG3790	cyd operon protein YbgE
L6426_RS03810	COG0824	Thioesterase
L6426_RS03815	COG0811	peptide transport
L6426_RS03830	COG0823	Involved in the tonB-independent uptake of proteins
L6426_RS03835	COG2885	chlorophyll binding
L6426_RS03840	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
L6426_RS03915	COG0840	transmembrane signaling receptor activity
L6426_RS03920	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L6426_RS03930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L6426_RS03935	COG1640	4-alpha-glucanotransferase
L6426_RS03940	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L6426_RS03970	COG2130	NADP-dependent
L6426_RS03975	COG1846	Transcriptional regulator
L6426_RS04005	COG0561	phosphatase activity
L6426_RS04020	COG0733	neurotransmitter:sodium symporter activity
L6426_RS04025	COG0733	neurotransmitter:sodium symporter activity
L6426_RS04040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6426_RS04055	COG1794	racemase activity, acting on amino acids and derivatives
L6426_RS04065	COG1022	Amp-dependent synthetase and ligase
L6426_RS04075	COG0456	acetyltransferase
L6426_RS04090	COG2425	protein containing a von Willebrand factor type A (vWA) domain
L6426_RS04095	COG5001	Diguanylate cyclase
L6426_RS04095	COG5002	protein histidine kinase activity
L6426_RS04125	COG0456	acetyltransferase
L6426_RS04130	COG1902	pentaerythritol trinitrate reductase activity
L6426_RS04145	COG2957	Belongs to the agmatine deiminase family
L6426_RS04150	COG0154	amidase activity
L6426_RS04185	COG1917	Cupin 2, conserved barrel domain protein
L6426_RS04185	COG2207	Transcriptional regulator
L6426_RS04195	COG0513	Belongs to the DEAD box helicase family
L6426_RS04200	COG2203	Gaf domain
L6426_RS04200	COG2199	diguanylate cyclase activity
L6426_RS04235	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
L6426_RS04245	COG0577	efflux transmembrane transporter activity
L6426_RS04245	COG1136	(ABC) transporter
L6426_RS04250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6426_RS04255	COG0745	RESPONSE REGULATOR receiver
L6426_RS04260	COG2205	protein histidine kinase activity
L6426_RS04315	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L6426_RS04325	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L6426_RS04330	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
L6426_RS04335	COG1178	ABC-type Fe3 transport system permease component
L6426_RS04340	COG4143	(ABC) transporter
L6426_RS04355	COG0066	3-isopropylmalate dehydratase activity
L6426_RS04360	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L6426_RS04365	COG0473	3-isopropylmalate dehydrogenase activity
L6426_RS04370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L6426_RS04380	COG0671	phosphoesterase, PA-phosphatase related
L6426_RS04395	COG0028	Belongs to the TPP enzyme family
L6426_RS04400	COG0440	acetolactate synthase activity
L6426_RS04405	COG0857	belongs to the CobB CobQ family
L6426_RS04405	COG0280	phosphate acetyltransferase
L6426_RS04410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L6426_RS04415	COG3092	negative regulation of chromosome organization
L6426_RS04420	COG3013	Belongs to the UPF0304 family
L6426_RS04425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L6426_RS04430	COG2716	regulation of RNA biosynthetic process
L6426_RS04435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L6426_RS04440	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
L6426_RS04445	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L6426_RS04460	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L6426_RS04480	COG0784	Response regulator, receiver
L6426_RS04480	COG2198	Histidine kinase
L6426_RS04480	COG5002	protein histidine kinase activity
L6426_RS04485	COG0232	Belongs to the dGTPase family. Type 2 subfamily
L6426_RS04500	COG0784	Response regulator, receiver
L6426_RS04500	COG2205	protein histidine kinase activity
L6426_RS04510	COG0840	transmembrane signaling receptor activity
L6426_RS04520	COG1464	Belongs to the NlpA lipoprotein family
L6426_RS04525	COG2011	ABC-type metal ion transport system permease component
L6426_RS04530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L6426_RS04550	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L6426_RS04550	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L6426_RS04555	COG0802	atpase or kinase
L6426_RS04565	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L6426_RS04570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L6426_RS04575	COG1923	regulation of RNA biosynthetic process
L6426_RS04580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L6426_RS04585	COG0330	HflC and HflK could
L6426_RS04590	COG0330	HflC and HflK could
L6426_RS04595	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
L6426_RS04600	COG0142	geranyltranstransferase activity
L6426_RS04605	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L6426_RS04610	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L6426_RS04615	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L6426_RS04620	COG3314	Sporulation integral membrane protein YlbJ
L6426_RS04625	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
L6426_RS04630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L6426_RS04640	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L6426_RS04645	COG2967	ApaG domain
L6426_RS04650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L6426_RS04655	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
L6426_RS04665	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
L6426_RS04670	COG3178	'Phosphotransferase
L6426_RS04675	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L6426_RS04680	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
L6426_RS04685	COG2252	PERMEase
L6426_RS04695	COG0488	(ABC) transporter
L6426_RS04700	COG0582	viral genome integration into host DNA
L6426_RS04785	COG1846	Transcriptional regulator
L6426_RS04800	COG3646	Phage regulatory protein
L6426_RS04850	COG4626	Terminase
L6426_RS04850	COG1802	Transcriptional regulator
L6426_RS04955	COG0741	lytic transglycosylase activity
L6426_RS04960	COG0463	Glycosyl transferase, family 2
L6426_RS04970	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
L6426_RS05000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6426_RS05010	COG3721	Heme iron utilization protein
L6426_RS05015	COG0748	coenzyme F420 binding
L6426_RS05040	COG2814	Major facilitator Superfamily
L6426_RS05045	COG2202	Pas domain
L6426_RS05045	COG2205	protein histidine kinase activity
L6426_RS05055	COG2226	methyltransferase
L6426_RS05065	COG1765	OsmC-like protein
L6426_RS05080	COG3954	Phosphoribulokinase
L6426_RS05085	COG3089	Belongs to the UPF0270 family
L6426_RS05090	COG5001	Diguanylate cyclase
L6426_RS05090	COG4251	negative regulation of phosphorylation
L6426_RS05090	COG3706	GGDEF domain
L6426_RS05090	COG2203	Gaf domain
L6426_RS05095	COG0429	hydrolase of the alpha beta-hydrolase fold
L6426_RS05100	COG0835	chemotaxis
L6426_RS05100	COG0784	Response regulator, receiver
L6426_RS05110	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L6426_RS05115	COG1047	Peptidyl-prolyl cis-trans
L6426_RS05120	COG2900	Belongs to the SlyX family
L6426_RS05130	COG0545	Peptidyl-prolyl cis-trans isomerase
L6426_RS05135	COG2204	response regulator
L6426_RS05155	COG0737	Belongs to the 5'-nucleotidase family
L6426_RS05170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L6426_RS05175	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L6426_RS05175	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L6426_RS05175	COG0506	proline dehydrogenase activity
L6426_RS05185	COG0114	fumarate hydratase activity
L6426_RS05195	COG1566	PFAM secretion protein HlyD family protein
L6426_RS05265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6426_RS05275	COG1280	lysine exporter protein (LysE YggA)
L6426_RS05285	COG0826	peptidase U32
L6426_RS05295	COG3813	Protein conserved in bacteria
L6426_RS05315	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
L6426_RS05340	COG0300	oxidoreductase activity
L6426_RS05360	COG2610	gluconate transmembrane transporter activity
L6426_RS05365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6426_RS05370	COG3622	Belongs to the hyi family
L6426_RS05375	COG0235	Class ii aldolase
L6426_RS05385	COG2084	Dehydrogenase
L6426_RS05390	COG1349	DNA-binding transcription factor activity
L6426_RS05435	COG4397	Mu-like prophage major head subunit gpT
L6426_RS05470	COG2020	methyltransferase activity
L6426_RS05480	COG2916	Histone family protein nucleoid-structuring protein H-NS
L6426_RS05520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6426_RS05525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6426_RS05570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L6426_RS05575	COG4584	PFAM Integrase catalytic
L6426_RS05580	COG1484	DNA-dependent DNA replication
L6426_RS05590	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L6426_RS05630	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L6426_RS05660	COG0210	DNA helicase
L6426_RS05675	COG2801	Transposase and inactivated derivatives
L6426_RS05715	COG0077	Prephenate dehydratase
L6426_RS05715	COG1605	Chorismate mutase
L6426_RS05740	COG3272	Protein of unknown function (DUF1722)
L6426_RS05745	COG0789	Transcriptional regulator
L6426_RS05750	COG0415	Belongs to the DNA photolyase family
L6426_RS05760	COG4221	oxidoreductase activity
L6426_RS05775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L6426_RS05800	COG0783	Belongs to the Dps family
L6426_RS05805	COG1151	hydroxylamine reductase activity
L6426_RS05810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L6426_RS05815	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L6426_RS05830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6426_RS05835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6426_RS05845	COG5000	phosphorelay sensor kinase activity
L6426_RS05845	COG5002	protein histidine kinase activity
L6426_RS05855	COG0659	secondary active sulfate transmembrane transporter activity
L6426_RS05865	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L6426_RS05870	COG1666	GTP binding
L6426_RS05880	COG2211	Major facilitator Superfamily
L6426_RS05890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L6426_RS05900	COG2813	Specifically methylates the guanine in position
L6426_RS05905	COG0271	Belongs to the BolA IbaG family
L6426_RS05910	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L6426_RS05915	COG1805	sodium ion transport
L6426_RS05920	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L6426_RS05925	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L6426_RS05930	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L6426_RS05935	COG2871	sodium ion transport
L6426_RS05940	COG1477	protein flavinylation
L6426_RS05955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L6426_RS05960	COG0840	transmembrane signaling receptor activity
L6426_RS05965	COG0583	DNA-binding transcription factor activity
L6426_RS05980	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
L6426_RS05990	COG0473	3-isopropylmalate dehydrogenase activity
L6426_RS05995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6426_RS06000	COG1611	Belongs to the LOG family
L6426_RS06015	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L6426_RS06015	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L6426_RS06025	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
L6426_RS06050	COG3098	single-species biofilm formation
L6426_RS06055	COG0564	pseudouridine synthase activity
L6426_RS06070	COG4580	involved in the transport of maltose and maltodextrins
L6426_RS06080	COG1263	PTS System
L6426_RS06080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6426_RS06090	COG2171	N-acyltransferase activity
L6426_RS06095	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
L6426_RS06100	COG0024	Methionine aminopeptidase
L6426_RS06105	COG0052	Belongs to the universal ribosomal protein uS2 family
L6426_RS06110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L6426_RS06115	COG0528	UMP kinase activity
L6426_RS06120	COG0233	cytoplasmic translational termination
L6426_RS06125	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L6426_RS06130	COG0575	Belongs to the CDS family
L6426_RS06135	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L6426_RS06140	COG0750	zinc metalloprotease
L6426_RS06155	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L6426_RS06160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L6426_RS06165	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L6426_RS06170	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L6426_RS06175	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L6426_RS06180	COG0587	DNA-directed DNA polymerase activity
L6426_RS06185	COG0825	malonyl-CoA metabolic process
L6426_RS06200	COG0814	amino acid
L6426_RS06210	COG0531	amino acid
L6426_RS06220	COG0488	(ABC) transporter
L6426_RS06235	COG0037	tRNA processing
L6426_RS06240	COG3706	GGDEF domain
L6426_RS06275	COG0366	Alpha amylase catalytic
L6426_RS06290	COG0463	Glycosyl transferase, family 2
L6426_RS06305	COG2989	Protein conserved in bacteria
L6426_RS06310	COG3108	Peptidase M15
L6426_RS06320	COG2860	membrane
L6426_RS06330	COG1196	nuclear chromosome segregation
L6426_RS06335	COG3115	cell septum assembly
L6426_RS06340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L6426_RS06350	COG1328	CTP reductase activity
L6426_RS06355	COG0602	queuosine metabolic process
L6426_RS06380	COG1566	PFAM secretion protein HlyD family protein
L6426_RS06390	COG3290	protein histidine kinase activity
L6426_RS06405	COG0667	Aldo Keto reductase
L6426_RS06415	COG0697	spore germination
L6426_RS06430	COG3284	Transcriptional regulator
L6426_RS06435	COG3706	GGDEF domain
L6426_RS06440	COG0346	lactoylglutathione lyase activity
L6426_RS06445	COG0745	RESPONSE REGULATOR receiver
L6426_RS06450	COG5002	protein histidine kinase activity
L6426_RS06460	COG4783	chaperone-mediated protein folding
L6426_RS06480	COG0545	Peptidyl-prolyl cis-trans isomerase
L6426_RS06485	COG1131	(ABC) transporter
L6426_RS06490	COG0815	Transfers the fatty acyl group on membrane lipoproteins
L6426_RS06500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6426_RS06505	COG4597	amino acid ABC transporter
L6426_RS06510	COG0765	amino acid transport
L6426_RS06515	COG1126	abc transporter atp-binding protein
L6426_RS06525	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
L6426_RS06530	COG0678	peroxiredoxin activity
L6426_RS06540	COG0019	diaminopimelate decarboxylase activity
L6426_RS06545	COG1115	amino acid carrier protein
L6426_RS06550	COG0095	Lipoate-protein ligase
L6426_RS06575	COG2207	Transcriptional regulator
L6426_RS06580	COG0281	malic enzyme
L6426_RS06610	COG0733	neurotransmitter:sodium symporter activity
L6426_RS06615	COG1752	Esterase of the alpha-beta hydrolase superfamily
L6426_RS06620	COG3706	GGDEF domain
L6426_RS06630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6426_RS06635	COG1032	radical SAM domain protein
L6426_RS06640	COG2319	Wd-40 repeat
L6426_RS06640	COG3903	Transcriptional regulator
L6426_RS06660	COG0673	inositol 2-dehydrogenase activity
L6426_RS06665	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L6426_RS06670	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L6426_RS06700	COG0741	lytic transglycosylase activity
L6426_RS06700	COG0739	heme binding
L6426_RS06700	COG1196	nuclear chromosome segregation
L6426_RS06725	COG0788	formyltetrahydrofolate deformylase activity
L6426_RS06730	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L6426_RS06740	COG3118	belongs to the thioredoxin family
L6426_RS06750	COG0791	NLP P60 protein
L6426_RS06755	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
L6426_RS06780	COG3318	Belongs to the UPF0149 family
L6426_RS06780	COG3012	SEC-C Motif Domain Protein
L6426_RS06805	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L6426_RS06850	COG2003	Belongs to the UPF0758 family
L6426_RS06895	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L6426_RS06915	COG3311	Transcriptional regulator
L6426_RS06925	COG0582	viral genome integration into host DNA
L6426_RS06930	COG0784	Response regulator, receiver
L6426_RS06930	COG2205	protein histidine kinase activity
L6426_RS06955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6426_RS06955	COG2205	protein histidine kinase activity
L6426_RS06960	COG3384	dioxygenase
L6426_RS06970	COG1283	sodium-dependent phosphate transmembrane transporter activity
L6426_RS06980	COG0531	amino acid
L6426_RS06985	COG0531	amino acid
L6426_RS07000	COG1012	belongs to the aldehyde dehydrogenase family
L6426_RS07005	COG1396	sequence-specific DNA binding
L6426_RS07005	COG1917	Cupin 2, conserved barrel domain protein
L6426_RS07010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6426_RS07045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L6426_RS07045	COG4651	solute:proton antiporter activity
L6426_RS07060	COG2974	May be involved in recombination
L6426_RS07065	COG1247	-acetyltransferase
L6426_RS07070	COG0420	3'-5' exonuclease activity
L6426_RS07080	COG3038	cytochrome b561
L6426_RS07085	COG2190	(PTS) system
L6426_RS07095	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6426_RS07100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6426_RS07105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L6426_RS07120	COG1720	tRNA m6t6A37 methyltransferase activity
L6426_RS07140	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
L6426_RS07145	COG4988	ABC transporter
L6426_RS07160	COG0745	RESPONSE REGULATOR receiver
L6426_RS07170	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L6426_RS07185	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
L6426_RS07190	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
L6426_RS07200	COG0083	homoserine kinase activity
L6426_RS07205	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L6426_RS07235	COG1943	Transposase
L6426_RS07245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6426_RS07255	COG3220	belongs to the UPF0276 family
L6426_RS07285	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
L6426_RS07290	COG1289	transmembrane transporter activity
L6426_RS07295	COG1763	Mo-molybdopterin cofactor biosynthetic process
L6426_RS07300	COG0746	molybdenum cofactor guanylyltransferase activity
L6426_RS07305	COG0281	malic enzyme
L6426_RS07335	COG1196	nuclear chromosome segregation
L6426_RS07335	COG3264	Mechanosensitive ion channel
L6426_RS07350	COG2850	peptidyl-arginine hydroxylation
L6426_RS07355	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L6426_RS07360	COG2915	High frequency lysogenization protein hflD homolog
L6426_RS07365	COG0482	sulfurtransferase activity
L6426_RS07375	COG1187	pseudouridine synthase activity
L6426_RS07380	COG0456	acetyltransferase
L6426_RS07420	COG0538	isocitrate dehydrogenase activity
L6426_RS07430	COG3048	D-serine ammonia-lyase activity
L6426_RS07435	COG0583	DNA-binding transcription factor activity
L6426_RS07440	COG2916	Histone family protein nucleoid-structuring protein H-NS
L6426_RS07445	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L6426_RS07450	COG2375	cellular response to nickel ion
L6426_RS07455	COG1538	Outer membrane efflux protein
L6426_RS07460	COG0577	efflux transmembrane transporter activity
L6426_RS07460	COG1136	(ABC) transporter
L6426_RS07465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6426_RS07475	COG0497	DNA recombination
L6426_RS07480	COG3706	GGDEF domain
L6426_RS07485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L6426_RS07490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L6426_RS07495	COG0443	Heat shock 70 kDa protein
L6426_RS07500	COG0484	heat shock protein binding
L6426_RS07530	COG1285	pathogenesis
L6426_RS07540	COG0446	pyridine nucleotide-disulphide oxidoreductase
L6426_RS07550	COG0640	Transcriptional regulator
L6426_RS07580	COG0095	Lipoate-protein ligase
L6426_RS07595	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6426_RS07600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6426_RS07610	COG0708	Exodeoxyribonuclease III
L6426_RS07620	COG0745	RESPONSE REGULATOR receiver
L6426_RS07635	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
L6426_RS07650	COG1846	Transcriptional regulator
L6426_RS07670	COG0583	DNA-binding transcription factor activity
L6426_RS07675	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L6426_RS07680	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L6426_RS07685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L6426_RS07690	COG1845	cytochrome c oxidase, subunit III
L6426_RS07695	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L6426_RS07700	COG0109	protoheme IX farnesyltransferase activity
L6426_RS07710	COG2814	Major facilitator Superfamily
L6426_RS07715	COG5507	3-demethylubiquinone-9 3-methyltransferase
L6426_RS07755	COG0159	tryptophan synthase activity
L6426_RS07760	COG0133	tryptophan synthase activity
L6426_RS07765	COG0134	indole-3-glycerol-phosphate synthase activity
L6426_RS07765	COG0135	phosphoribosylanthranilate isomerase activity
L6426_RS07770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L6426_RS07775	COG0512	Glutamine amidotransferase of anthranilate synthase
L6426_RS07775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L6426_RS07780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L6426_RS07785	COG0613	PHP domain protein
L6426_RS07790	COG0009	L-threonylcarbamoyladenylate synthase
L6426_RS07800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L6426_RS07810	COG1946	Acyl-CoA thioesterase
L6426_RS07825	COG1309	transcriptional regulator
L6426_RS07830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6426_RS07835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6426_RS07890	COG2003	Belongs to the UPF0758 family
L6426_RS07905	COG4584	PFAM Integrase catalytic
L6426_RS07910	COG1484	DNA-dependent DNA replication
L6426_RS07915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L6426_RS07940	COG0583	DNA-binding transcription factor activity
L6426_RS07960	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L6426_RS07970	COG1960	acyl-CoA dehydrogenase activity
L6426_RS07975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6426_RS07985	COG0469	pyruvate kinase activity
L6426_RS07990	COG1737	Transcriptional regulator
L6426_RS08010	COG0675	Transposase, IS605 OrfB family
L6426_RS08025	COG1088	dTDP-glucose 4,6-dehydratase activity
L6426_RS08035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L6426_RS08040	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L6426_RS08045	COG2089	acid synthase
L6426_RS08070	COG2244	polysaccharide biosynthetic process
L6426_RS08090	COG1215	transferase activity, transferring glycosyl groups
L6426_RS08095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L6426_RS08115	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
L6426_RS08120	COG3039	Transposase
L6426_RS08130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L6426_RS08155	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L6426_RS08165	COG3132	Protein of unknown function, DUF480
L6426_RS08190	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L6426_RS08205	COG1278	Cold shock
L6426_RS08230	COG4166	transmembrane transport
L6426_RS08235	COG0697	spore germination
L6426_RS08245	COG0675	Transposase, IS605 OrfB family
L6426_RS08250	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
L6426_RS08265	COG4166	transmembrane transport
L6426_RS08270	COG0622	Phosphoesterase
L6426_RS08285	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
L6426_RS08290	COG0835	chemotaxis
L6426_RS08290	COG0784	Response regulator, receiver
L6426_RS08295	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L6426_RS08300	COG1815	bacterial-type flagellum-dependent cell motility
L6426_RS08315	COG1749	Flagellar hook protein flgE
L6426_RS08330	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
L6426_RS08335	COG1706	bacterial-type flagellum-dependent cell motility
L6426_RS08340	COG1705	Flagellar rod assembly protein muramidase FlgJ
L6426_RS08340	COG3951	Flagellar rod assembly protein muramidase FlgJ
L6426_RS08355	COG2239	Acts as a magnesium transporter
L6426_RS08365	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L6426_RS08370	COG2716	regulation of RNA biosynthetic process
L6426_RS08395	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L6426_RS08400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L6426_RS08405	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L6426_RS08410	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L6426_RS08430	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L6426_RS08445	COG0590	tRNA wobble adenosine to inosine editing
L6426_RS08450	COG0573	inorganic phosphate transmembrane transporter activity
L6426_RS08455	COG0581	inorganic phosphate transmembrane transporter activity
L6426_RS08460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L6426_RS08465	COG0704	Plays a role in the regulation of phosphate uptake
L6426_RS08470	COG1253	flavin adenine dinucleotide binding
L6426_RS08485	COG0531	amino acid
L6426_RS08500	COG1126	abc transporter atp-binding protein
L6426_RS08505	COG0765	amino acid transport
L6426_RS08510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6426_RS08515	COG3706	GGDEF domain
L6426_RS08520	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L6426_RS08540	COG1785	Belongs to the alkaline phosphatase family
L6426_RS08545	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L6426_RS08550	COG0477	Major facilitator Superfamily
L6426_RS08555	COG0123	including yeast histone deacetylase and acetoin utilization protein
L6426_RS08565	COG1199	ATP-dependent helicase activity
L6426_RS08585	COG1448	Aminotransferase
L6426_RS08590	COG0433	COG0433 Predicted ATPase
L6426_RS08605	COG2333	competence protein COMEC
L6426_RS08605	COG0658	competence protein
L6426_RS08610	COG1132	(ABC) transporter
L6426_RS08615	COG1663	tetraacyldisaccharide 4'-kinase activity
L6426_RS08620	COG2835	tetraacyldisaccharide 4'-kinase activity
L6426_RS08625	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
L6426_RS08630	COG2197	response regulator
L6426_RS08635	COG0322	excinuclease ABC activity
L6426_RS08680	COG0604	alcohol dehydrogenase
L6426_RS08685	COG1309	transcriptional regulator
L6426_RS08690	COG2261	transglycosylase associated protein
L6426_RS08695	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L6426_RS08705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L6426_RS08710	COG0215	cysteine-tRNA ligase activity
L6426_RS08735	COG2199	diguanylate cyclase activity
L6426_RS08735	COG2203	Gaf domain
L6426_RS08770	COG2119	membrane
L6426_RS08775	COG0023	Translation Initiation Factor
L6426_RS08785	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L6426_RS08810	COG4139	cobalamin transport
L6426_RS08815	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
L6426_RS08820	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L6426_RS08825	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L6426_RS08830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L6426_RS08835	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
L6426_RS08840	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L6426_RS08850	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L6426_RS08855	COG0505	Belongs to the CarA family
L6426_RS08860	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L6426_RS08865	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L6426_RS08870	COG3706	GGDEF domain
L6426_RS08900	COG0513	Belongs to the DEAD box helicase family
L6426_RS08910	COG4104	PAAR repeat-containing protein
L6426_RS08935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6426_RS08940	COG0765	amino acid transport
L6426_RS08945	COG1126	abc transporter atp-binding protein
L6426_RS08950	COG0493	'glutamate synthase
L6426_RS08955	COG0067	glutamate synthase
L6426_RS08955	COG0069	glutamate synthase activity
L6426_RS08955	COG0070	glutamate synthase
L6426_RS08960	COG1242	4 iron, 4 sulfur cluster binding
L6426_RS09005	COG1113	amino acid transport
L6426_RS09015	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
L6426_RS09020	COG0574	Belongs to the PEP-utilizing enzyme family
L6426_RS09020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L6426_RS09025	COG1119	ATPase activity
L6426_RS09040	COG1464	Belongs to the NlpA lipoprotein family
L6426_RS09050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L6426_RS09055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L6426_RS09065	COG0101	tRNA pseudouridine synthase activity
L6426_RS09070	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L6426_RS09075	COG0285	dihydrofolate synthase activity
L6426_RS09080	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
L6426_RS09085	COG2920	part of a sulfur-relay system
L6426_RS09095	COG0670	Belongs to the BI1 family
L6426_RS09135	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L6426_RS09145	COG5001	Diguanylate cyclase
L6426_RS09150	COG0564	pseudouridine synthase activity
L6426_RS09165	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
L6426_RS09175	COG0625	glutathione transferase activity
L6426_RS09190	COG0367	asparagine synthase
L6426_RS09200	COG0647	UMP catabolic process
L6426_RS09205	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L6426_RS09210	COG0604	alcohol dehydrogenase
L6426_RS09215	COG1902	pentaerythritol trinitrate reductase activity
L6426_RS09220	COG1253	flavin adenine dinucleotide binding
L6426_RS09230	COG0247	lactate metabolic process
L6426_RS09230	COG0277	FAD linked oxidase domain protein
L6426_RS09240	COG2050	protein possibly involved in aromatic compounds catabolism
L6426_RS09255	COG5001	Diguanylate cyclase
L6426_RS09260	COG0583	DNA-binding transcription factor activity
L6426_RS09265	COG2814	Major facilitator Superfamily
L6426_RS09270	COG2056	Na+-H+ antiporter family
L6426_RS09275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L6426_RS09290	COG0483	inositol monophosphate 1-phosphatase activity
L6426_RS09300	COG0625	glutathione transferase activity
L6426_RS09305	COG0625	glutathione transferase activity
L6426_RS09315	COG0601	transmembrane transport
L6426_RS09320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6426_RS09325	COG0444	Belongs to the ABC transporter superfamily
L6426_RS09330	COG2814	Major facilitator Superfamily
L6426_RS09350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L6426_RS09355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L6426_RS09360	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L6426_RS09365	COG0509	glycine decarboxylation via glycine cleavage system
L6426_RS09370	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L6426_RS09370	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L6426_RS09395	COG3634	alkyl hydroperoxide reductase activity
L6426_RS09400	COG0450	alkyl hydroperoxide reductase
L6426_RS09405	COG0517	IMP dehydrogenase activity
L6426_RS09410	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
L6426_RS09415	COG0343	queuine tRNA-ribosyltransferase activity
L6426_RS09420	COG1862	Preprotein translocase
L6426_RS09425	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6426_RS09430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6426_RS09435	COG2897	thiosulfate sulfurtransferase activity
L6426_RS09445	COG0826	peptidase U32
L6426_RS09450	COG0826	peptidase U32
L6426_RS09455	COG3154	lipid carrier protein
L6426_RS09470	COG1104	cysteine desulfurase activity
L6426_RS09475	COG0822	iron-sulfur transferase activity
L6426_RS09485	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
L6426_RS09490	COG0443	Heat shock 70 kDa protein
L6426_RS09495	COG0633	Ferredoxin
L6426_RS09505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L6426_RS09510	COG0105	UTP biosynthetic process
L6426_RS09515	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L6426_RS09525	COG1426	Protein conserved in bacteria
L6426_RS09535	COG0124	histidyl-tRNA synthetase
L6426_RS09540	COG2976	Protein conserved in bacteria
L6426_RS09545	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L6426_RS09550	COG1160	GTP binding
L6426_RS09555	COG1645	bacterial-type flagellum-dependent swarming motility
L6426_RS09560	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
L6426_RS09565	COG0047	phosphoribosylformylglycinamidine synthase activity
L6426_RS09565	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L6426_RS09570	COG1007	ATP synthesis coupled electron transport
L6426_RS09575	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6426_RS09585	COG0713	ATP synthesis coupled electron transport
L6426_RS09590	COG0839	Belongs to the complex I subunit 6 family
L6426_RS09595	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6426_RS09600	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L6426_RS09605	COG1034	ATP synthesis coupled electron transport
L6426_RS09620	COG0649	NAD binding
L6426_RS09620	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6426_RS09625	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6426_RS09630	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6426_RS09635	COG1360	Flagellar Motor Protein
L6426_RS09640	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6426_RS09655	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L6426_RS09665	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
L6426_RS09675	COG0724	RNA recognition motif
L6426_RS09680	COG4989	oxidoreductase activity
L6426_RS09705	COG0745	RESPONSE REGULATOR receiver
L6426_RS09710	COG0583	DNA-binding transcription factor activity
L6426_RS09720	COG5001	Diguanylate cyclase
L6426_RS09720	COG3300	MHYT domain
L6426_RS09725	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
L6426_RS09755	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L6426_RS09760	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L6426_RS09765	COG0539	negative regulation of cytoplasmic translation
L6426_RS09770	COG0776	regulation of translation
L6426_RS09780	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
L6426_RS09800	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L6426_RS09805	COG0602	queuosine metabolic process
L6426_RS09810	COG3530	Putative quorum-sensing-regulated virulence factor
L6426_RS09815	COG2096	Adenosyltransferase
L6426_RS09820	COG2916	Histone family protein nucleoid-structuring protein H-NS
L6426_RS09825	COG1757	Na H antiporter
L6426_RS09830	COG1435	thymidine kinase activity
L6426_RS09850	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L6426_RS09865	COG1349	DNA-binding transcription factor activity
L6426_RS09870	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
L6426_RS09880	COG3550	peptidyl-serine autophosphorylation
L6426_RS09955	COG3039	Transposase
L6426_RS09970	COG2197	response regulator
L6426_RS10070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L6426_RS10080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6426_RS10085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6426_RS10130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L6426_RS10140	COG1397	ADP-ribosylglycohydrolase
L6426_RS10210	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L6426_RS10255	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L6426_RS10260	COG0626	cystathionine gamma-synthase activity
L6426_RS10270	COG2910	NAD(P)H-binding
L6426_RS10275	COG0583	DNA-binding transcription factor activity
L6426_RS10280	COG4977	sequence-specific DNA binding
L6426_RS10280	COG1917	Cupin 2, conserved barrel domain protein
L6426_RS10285	COG2200	EAL domain
L6426_RS10290	COG3706	GGDEF domain
L6426_RS10295	COG4774	siderophore transport
L6426_RS10305	COG0583	DNA-binding transcription factor activity
L6426_RS10310	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L6426_RS10320	COG0617	tRNA 3'-terminal CCA addition
L6426_RS10320	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L6426_RS10320	COG0517	IMP dehydrogenase activity
L6426_RS10325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6426_RS10330	COG3046	protein related to deoxyribodipyrimidine photolyase
L6426_RS10345	COG3088	subunit of a heme lyase
L6426_RS10345	COG4235	cytochrome complex assembly
L6426_RS10350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6426_RS10355	COG1138	Cytochrome C-type biogenesis protein
L6426_RS10360	COG3301	Polysulphide reductase, NrfD
L6426_RS10365	COG0437	4 iron, 4 sulfur cluster binding
L6426_RS10370	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
L6426_RS10390	COG0247	lactate metabolic process
L6426_RS10400	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
L6426_RS10405	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L6426_RS10410	COG3012	SEC-C Motif Domain Protein
L6426_RS10415	COG0840	transmembrane signaling receptor activity
L6426_RS10420	COG1846	Transcriptional regulator
L6426_RS10420	COG1940	carbohydrate kinase activity
L6426_RS10425	COG3290	protein histidine kinase activity
L6426_RS10430	COG4565	transcriptional regulatory protein
L6426_RS10445	COG3181	Tripartite tricarboxylate transporter family receptor
L6426_RS10450	COG1196	nuclear chromosome segregation
L6426_RS10450	COG0741	lytic transglycosylase activity
L6426_RS10450	COG0739	heme binding
L6426_RS10455	COG0569	domain protein
L6426_RS10455	COG2985	domain, Protein
L6426_RS10465	COG0556	nucleotide-excision repair
L6426_RS10475	COG0586	Pfam SNARE associated Golgi protein
L6426_RS10480	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
L6426_RS10485	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L6426_RS10490	COG2186	Transcriptional regulator
L6426_RS10495	COG2719	SpoVR family
L6426_RS10500	COG2718	Belongs to the UPF0229 family
L6426_RS10505	COG2766	serine protein kinase
L6426_RS10510	COG0514	ATP-dependent DNA helicase (RecQ)
L6426_RS10515	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
L6426_RS10520	COG0814	amino acid
L6426_RS10555	COG0058	SHG alpha-glucan phosphorylase activity
L6426_RS10565	COG0471	metal ion transport
L6426_RS10570	COG3118	belongs to the thioredoxin family
L6426_RS10580	COG1132	(ABC) transporter
L6426_RS10585	COG1132	(ABC) transporter
L6426_RS10600	COG2501	S4 domain
L6426_RS10610	COG3243	poly(R)-hydroxyalkanoic acid synthase
L6426_RS10630	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
L6426_RS10635	COG2329	Antibiotic biosynthesis monooxygenase
L6426_RS10660	COG1742	UPF0060 membrane protein
L6426_RS10675	COG0513	Belongs to the DEAD box helicase family
L6426_RS10680	COG0386	Belongs to the glutathione peroxidase family
L6426_RS10690	COG1181	Belongs to the D-alanine--D-alanine ligase family
L6426_RS10695	COG3148	PFAM DTW domain containing protein
L6426_RS10705	COG0730	response to heat
L6426_RS10710	COG0583	DNA-binding transcription factor activity
L6426_RS10725	COG3593	DNA synthesis involved in DNA repair
L6426_RS10770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L6426_RS10775	COG1011	Hydrolase
L6426_RS10780	COG1473	amidohydrolase
L6426_RS10785	COG0205	6-phosphofructokinase activity
L6426_RS10795	COG1434	Gram-negative-bacterium-type cell wall biogenesis
L6426_RS10800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L6426_RS10810	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
L6426_RS10815	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
L6426_RS10840	COG0588	phosphoglycerate mutase activity
L6426_RS10850	COG0675	Transposase, IS605 OrfB family
L6426_RS10865	COG1280	lysine exporter protein (LysE YggA)
L6426_RS10880	COG2824	Alkylphosphonate utilization operon protein PhnA
L6426_RS10925	COG2840	Smr protein MutS2
L6426_RS10930	COG2890	protein-(glutamine-N5) methyltransferase activity
L6426_RS10935	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L6426_RS10945	COG0513	Belongs to the DEAD box helicase family
L6426_RS10950	COG5654	RES domain protein
L6426_RS10960	COG0814	amino acid
L6426_RS10965	COG1609	Transcriptional regulator
L6426_RS10970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6426_RS10970	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6426_RS10975	COG1105	Belongs to the carbohydrate kinase PfkB family
L6426_RS10980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6426_RS10980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6426_RS10980	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L6426_RS10985	COG3313	Fe-S protein
L6426_RS10990	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
L6426_RS10995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L6426_RS11000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L6426_RS11005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L6426_RS11015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L6426_RS11045	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L6426_RS11050	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L6426_RS11055	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L6426_RS11060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L6426_RS11065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L6426_RS11070	COG0072	phenylalanine-tRNA ligase activity
L6426_RS11070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6426_RS11075	COG0776	regulation of translation
L6426_RS11110	COG0675	Transposase, IS605 OrfB family
L6426_RS11125	COG0037	tRNA processing
L6426_RS11130	COG0589	response to stress
L6426_RS11135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6426_RS11150	COG2217	Heavy metal translocating P-type atpase
L6426_RS11160	COG2010	Cytochrome c
L6426_RS11175	COG3278	Belongs to the heme-copper respiratory oxidase family
L6426_RS11190	COG1956	GAF domain-containing protein
L6426_RS11195	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
L6426_RS11205	COG0308	aminopeptidase N
L6426_RS11215	COG2902	Dehydrogenase
L6426_RS11225	COG0167	dihydroorotate dehydrogenase activity
L6426_RS11235	COG0116	Belongs to the methyltransferase superfamily
L6426_RS11235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L6426_RS11245	COG0488	(ABC) transporter
L6426_RS11260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L6426_RS11265	COG1067	ATP-dependent peptidase activity
L6426_RS11295	COG5642	Protein of unknown function (DUF2384)
L6426_RS11300	COG0583	DNA-binding transcription factor activity
L6426_RS11305	COG1979	alcohol dehydrogenase
L6426_RS11310	COG0667	Aldo Keto reductase
L6426_RS11325	COG2814	Major facilitator Superfamily
L6426_RS11335	COG0667	Aldo Keto reductase
L6426_RS11345	COG5002	protein histidine kinase activity
L6426_RS11370	COG0656	L-ascorbic acid biosynthetic process
L6426_RS11375	COG1028	Short-chain dehydrogenase reductase Sdr
L6426_RS11390	COG1028	Short-chain dehydrogenase reductase Sdr
L6426_RS11410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6426_RS11445	COG4115	mRNA cleavage
L6426_RS11450	COG2161	toxin-antitoxin pair type II binding
L6426_RS11520	COG3547	Transposase (IS116 IS110 IS902 family)
L6426_RS11545	COG1695	Transcriptional regulator
L6426_RS11570	COG3173	Aminoglycoside phosphotransferase
L6426_RS11595	COG0840	transmembrane signaling receptor activity
L6426_RS11605	COG1484	DNA-dependent DNA replication
L6426_RS11610	COG4584	PFAM Integrase catalytic
L6426_RS11675	COG0667	Aldo Keto reductase
L6426_RS11680	COG0583	DNA-binding transcription factor activity
L6426_RS11685	COG1064	alcohol dehydrogenase
L6426_RS11710	COG1609	Transcriptional regulator
L6426_RS11720	COG5499	transcription regulator containing HTH domain
L6426_RS11760	COG3141	response to X-ray
L6426_RS11770	COG2995	paraquat-inducible protein a
L6426_RS11775	COG3008	intermembrane lipid transfer
L6426_RS11780	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
L6426_RS11780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L6426_RS11795	COG0084	hydrolase, TatD family'
L6426_RS11800	COG0470	DNA polymerase III
L6426_RS11805	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L6426_RS11810	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L6426_RS11815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6426_RS11820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L6426_RS11825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6426_RS11830	COG1028	Short-chain dehydrogenase reductase Sdr
L6426_RS11840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6426_RS11845	COG0416	fatty acid biosynthetic process
L6426_RS11850	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L6426_RS11855	COG1399	metal-binding, possibly nucleic acid-binding protein
L6426_RS11870	COG0564	pseudouridine synthase activity
L6426_RS11875	COG1530	ribonuclease E activity
L6426_RS11880	COG0306	phosphate transporter
L6426_RS11885	COG0717	Belongs to the dCTP deaminase family
L6426_RS11890	COG0572	uridine kinase
L6426_RS11895	COG0489	protein tyrosine kinase activity
L6426_RS11900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6426_RS11900	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6426_RS11910	COG1254	Belongs to the acylphosphatase family
L6426_RS11915	COG0840	transmembrane signaling receptor activity
L6426_RS11920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L6426_RS11940	COG0709	Synthesizes selenophosphate from selenide and ATP
L6426_RS11945	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
L6426_RS11950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6426_RS11955	COG3437	response regulator, receiver
L6426_RS11970	COG2205	protein histidine kinase activity
L6426_RS11970	COG5002	protein histidine kinase activity
L6426_RS11970	COG0784	Response regulator, receiver
L6426_RS11975	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L6426_RS11985	COG1643	Atp-dependent helicase
L6426_RS11990	COG0517	IMP dehydrogenase activity
L6426_RS11990	COG0617	tRNA 3'-terminal CCA addition
L6426_RS11990	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L6426_RS11995	COG2197	response regulator
L6426_RS12000	COG3314	Sporulation integral membrane protein YlbJ
L6426_RS12010	COG0583	DNA-binding transcription factor activity
L6426_RS12015	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L6426_RS12065	COG1074	ATP-dependent DNA helicase activity
L6426_RS12085	COG3039	Transposase
L6426_RS12095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L6426_RS12100	COG2832	Protein of unknown function (DUF454)
L6426_RS12105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L6426_RS12115	COG0697	spore germination
L6426_RS12130	COG0318	PFAM AMP-dependent synthetase and ligase
L6426_RS12135	COG0596	Alpha beta hydrolase
L6426_RS12145	COG1214	PFAM Peptidase M22, glycoprotease
L6426_RS12150	COG1199	ATP-dependent helicase activity
L6426_RS12160	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L6426_RS12165	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L6426_RS12170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L6426_RS12175	COG0131	Imidazoleglycerol-phosphate dehydratase
L6426_RS12175	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L6426_RS12180	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L6426_RS12185	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L6426_RS12190	COG3437	response regulator, receiver
L6426_RS12200	COG2205	protein histidine kinase activity
L6426_RS12200	COG0784	Response regulator, receiver
L6426_RS12200	COG2198	Histidine kinase
L6426_RS12205	COG0107	imidazoleglycerol-phosphate synthase activity
L6426_RS12210	COG0140	phosphoribosyl-ATP diphosphatase activity
L6426_RS12210	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L6426_RS12220	COG0318	PFAM AMP-dependent synthetase and ligase
L6426_RS12225	COG3134	Outer membrane lipoprotein
L6426_RS12240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6426_RS12260	COG4681	YaeQ
L6426_RS12270	COG1250	3-hydroxyacyl-CoA dehydrogenase
L6426_RS12270	COG1024	Enoyl-CoA hydratase
L6426_RS12275	COG0183	Belongs to the thiolase family
L6426_RS12280	COG0714	Associated with various cellular activities
L6426_RS12310	COG1595	DNA-templated transcription, initiation
L6426_RS12320	COG2067	long-chain fatty acid transport protein
L6426_RS12325	COG2067	long-chain fatty acid transport protein
L6426_RS12330	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
L6426_RS12345	COG1301	dicarboxylic acid transport
L6426_RS12350	COG3123	guanosine phosphorylase activity
L6426_RS12355	COG1760	l-serine dehydratase
L6426_RS12360	COG1760	l-serine dehydratase
L6426_RS12365	COG2951	lytic endotransglycosylase activity
L6426_RS12370	COG3100	YcgL domain-containing protein
L6426_RS12375	COG0850	regulation of cytokinetic process
L6426_RS12380	COG2894	cell division
L6426_RS12385	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
L6426_RS12390	COG3099	Belongs to the UPF0263 family
L6426_RS12395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6426_RS12410	COG2996	Protein conserved in bacteria
L6426_RS12415	COG0675	Transposase, IS605 OrfB family
L6426_RS12445	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L6426_RS12455	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
L6426_RS12460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L6426_RS12475	COG0307	riboflavin synthase, alpha
L6426_RS12485	COG0534	Mate efflux family protein
L6426_RS12515	COG0417	DNA replication proofreading
L6426_RS12530	COG1560	Kdo2-lipid A biosynthetic process
L6426_RS12535	COG1560	Kdo2-lipid A biosynthetic process
L6426_RS12545	COG0583	DNA-binding transcription factor activity
L6426_RS12550	COG0673	inositol 2-dehydrogenase activity
L6426_RS12555	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
L6426_RS12570	COG0583	DNA-binding transcription factor activity
L6426_RS12580	COG2723	6-phospho-beta-galactosidase activity
L6426_RS12585	COG0583	DNA-binding transcription factor activity
L6426_RS12595	COG0243	molybdopterin cofactor binding
L6426_RS12600	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L6426_RS12615	COG0583	DNA-binding transcription factor activity
L6426_RS12620	COG1879	ABC-type sugar transport system periplasmic component
L6426_RS12625	COG1129	ABC transporter
L6426_RS12630	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6426_RS12635	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6426_RS12650	COG0730	response to heat
L6426_RS12660	COG1028	Short-chain dehydrogenase reductase Sdr
L6426_RS12670	COG1024	Enoyl-CoA hydratase
L6426_RS12675	COG1024	Enoyl-CoA hydratase
L6426_RS12680	COG1960	acyl-CoA dehydrogenase activity
L6426_RS12690	COG1960	acyl-CoA dehydrogenase activity
L6426_RS12695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L6426_RS12700	COG1024	Enoyl-CoA hydratase
L6426_RS12725	COG1584	GPR1 FUN34 yaaH family protein
L6426_RS12730	COG3228	Belongs to the MtfA family
L6426_RS12740	COG1115	amino acid carrier protein
L6426_RS12745	COG1024	Enoyl-CoA hydratase
L6426_RS12760	COG3162	membrane
L6426_RS12765	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6426_RS12770	COG0488	(ABC) transporter
L6426_RS12775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6426_RS12780	COG0776	regulation of translation
L6426_RS12785	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L6426_RS12790	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L6426_RS12795	COG0740	serine-type endopeptidase activity
L6426_RS12800	COG0544	peptidyl-prolyl cis-trans isomerase activity
L6426_RS12810	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
L6426_RS12815	COG4591	ABC-type transport system involved in lipoprotein release permease component
L6426_RS12820	COG1136	(ABC) transporter
L6426_RS12825	COG4591	ABC-type transport system involved in lipoprotein release permease component
L6426_RS12835	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L6426_RS12840	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
L6426_RS12855	COG0697	spore germination
L6426_RS12865	COG2062	phosphohistidine phosphatase, SixA
L6426_RS12885	COG1846	Transcriptional regulator
L6426_RS12915	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L6426_RS12925	COG4584	PFAM Integrase catalytic
L6426_RS12930	COG1484	DNA-dependent DNA replication
L6426_RS12965	COG0582	viral genome integration into host DNA
L6426_RS12970	COG0519	Catalyzes the synthesis of GMP from XMP
L6426_RS12970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L6426_RS12975	COG0517	IMP dehydrogenase activity
L6426_RS12975	COG0516	GMP reductase activity
L6426_RS12985	COG1874	Beta-galactosidase
L6426_RS12985	COG0366	Alpha amylase catalytic
L6426_RS12995	COG1570	exodeoxyribonuclease VII activity
L6426_RS13005	COG2885	chlorophyll binding
L6426_RS13025	COG2154	pterin-4-alpha-carbinolamine dehydratase
L6426_RS13035	COG3768	UPF0283 membrane protein
L6426_RS13040	COG3106	COG3106 Predicted ATPase
L6426_RS13055	COG1842	Phage shock protein A
L6426_RS13060	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
L6426_RS13075	COG4171	peptide transport system, permease
L6426_RS13085	COG4172	Belongs to the ABC transporter superfamily
L6426_RS13095	COG1609	Transcriptional regulator
L6426_RS13100	COG1263	PTS System
L6426_RS13100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6426_RS13105	COG2723	6-phospho-beta-galactosidase activity
L6426_RS13110	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L6426_RS13115	COG1286	toxin biosynthetic process
L6426_RS13120	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L6426_RS13125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L6426_RS13130	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L6426_RS13135	COG1674	ftsk spoiiie
L6426_RS13135	COG0531	amino acid
L6426_RS13145	COG0686	Belongs to the AlaDH PNT family
L6426_RS13150	COG0492	ferredoxin-NADP+ reductase activity
L6426_RS13155	COG3706	GGDEF domain
L6426_RS13160	COG3134	Outer membrane lipoprotein
L6426_RS13165	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L6426_RS13170	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
L6426_RS13175	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L6426_RS13180	COG0542	response to heat
L6426_RS13185	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L6426_RS13190	COG1278	Cold shock
L6426_RS13195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L6426_RS13210	COG1944	ATP diphosphatase activity
L6426_RS13215	COG2116	formate transmembrane transporter activity
L6426_RS13220	COG1882	Formate acetyltransferase
L6426_RS13230	COG2983	Belongs to the UPF0260 family
L6426_RS13255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L6426_RS13260	COG0045	succinate-CoA ligase (ADP-forming) activity
L6426_RS13265	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6426_RS13270	COG0567	Dehydrogenase, E1 component
L6426_RS13285	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L6426_RS13290	COG2009	succinate dehydrogenase
L6426_RS13310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L6426_RS13315	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L6426_RS13315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6426_RS13325	COG3069	C4-dicarboxylate transmembrane transporter activity
L6426_RS13340	COG1451	nucleotide metabolic process
L6426_RS13355	COG0254	rRNA binding
L6426_RS13360	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L6426_RS13370	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6426_RS13375	COG1129	ABC transporter
L6426_RS13380	COG1879	ABC-type sugar transport system periplasmic component
L6426_RS13385	COG1069	ribulokinase activity
L6426_RS13400	COG0583	DNA-binding transcription factor activity
L6426_RS13405	COG0436	Aminotransferase
L6426_RS13410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L6426_RS13425	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
L6426_RS13425	COG0392	lysyltransferase activity
L6426_RS13430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L6426_RS13440	COG0469	pyruvate kinase activity
L6426_RS13450	COG1263	PTS System
L6426_RS13450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6426_RS13455	COG1874	Beta-galactosidase
L6426_RS13460	COG3867	Arabinogalactan endo-beta-1,4-galactanase
L6426_RS13465	COG3833	ABC-type maltose transport systems, permease component
L6426_RS13470	COG1175	transmembrane transport
L6426_RS13475	COG2182	Extracellular solute-binding protein
L6426_RS13500	COG4580	involved in the transport of maltose and maltodextrins
L6426_RS13505	COG1609	Transcriptional regulator
L6426_RS13510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L6426_RS13515	COG1085	galactose-1-phosphate uridylyltransferase
L6426_RS13520	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
L6426_RS13530	COG0582	viral genome integration into host DNA
L6426_RS13540	COG2925	Exonuclease
L6426_RS13550	COG3345	alpha-galactosidase
L6426_RS13555	COG1380	Effector of murein hydrolase LrgA
L6426_RS13560	COG1346	cytolysis
L6426_RS13565	COG0295	cytidine deaminase activity
L6426_RS13570	COG1022	Amp-dependent synthetase and ligase
L6426_RS13585	COG0861	Integral membrane protein TerC family
L6426_RS13590	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L6426_RS13595	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L6426_RS13600	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
L6426_RS13640	COG4771	TonB-dependent receptor
L6426_RS13645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6426_RS13650	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6426_RS13655	COG1120	ATPase activity
L6426_RS13670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L6426_RS13680	COG1028	Short-chain dehydrogenase reductase Sdr
L6426_RS13685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L6426_RS13690	COG1535	isochorismatase
L6426_RS13690	COG3433	isochorismatase activity
L6426_RS13695	COG1021	2,3-dihydroxybenzoate-AMP ligase
L6426_RS13720	COG3300	MHYT domain
L6426_RS13720	COG5001	Diguanylate cyclase
L6426_RS13735	COG0840	transmembrane signaling receptor activity
L6426_RS13740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6426_RS13745	COG3788	relative of glutathione S-transferase, MAPEG superfamily
L6426_RS13750	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L6426_RS13755	COG0563	adenylate kinase activity
L6426_RS13760	COG0326	Molecular chaperone. Has ATPase activity
L6426_RS13765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L6426_RS13770	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
L6426_RS13775	COG0298	carbon dioxide binding
L6426_RS13785	COG0309	Hydrogenase expression formation protein (HypE)
L6426_RS13790	COG0375	protein maturation
L6426_RS13805	COG3842	ATPase activity
L6426_RS13885	COG0740	serine-type endopeptidase activity
L6426_RS13905	COG4220	transposase activity
L6426_RS13930	COG2135	peptidase activity
L6426_RS13935	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L6426_RS13985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6426_RS13990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6426_RS14010	COG3039	Transposase
L6426_RS14020	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
L6426_RS14050	COG1846	Transcriptional regulator
L6426_RS14100	COG2314	TM2 domain
L6426_RS14125	COG0582	viral genome integration into host DNA
L6426_RS14135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6426_RS14150	COG1773	rubredoxin
L6426_RS14155	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
L6426_RS14160	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
L6426_RS14165	COG5557	Pfam Polysulphide reductase, NrfD
L6426_RS14170	COG0437	4 iron, 4 sulfur cluster binding
L6426_RS14175	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
L6426_RS14180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L6426_RS14205	COG1484	DNA-dependent DNA replication
L6426_RS14210	COG4584	PFAM Integrase catalytic
L6426_RS14245	COG1401	restriction endodeoxyribonuclease activity
L6426_RS14265	COG0659	secondary active sulfate transmembrane transporter activity
L6426_RS14285	COG2308	Evidence 4 Homologs of previously reported genes of
L6426_RS14325	COG0672	)-iron permease
L6426_RS14350	COG2814	Major facilitator Superfamily
L6426_RS14370	COG1136	(ABC) transporter
L6426_RS14375	COG0577	efflux transmembrane transporter activity
L6426_RS14405	COG1139	Iron-sulfur cluster binding protein
L6426_RS14410	COG0247	lactate metabolic process
L6426_RS14415	COG1620	l-lactate permease
L6426_RS14420	COG0583	DNA-binding transcription factor activity
L6426_RS14445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6426_RS14450	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L6426_RS14450	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
L6426_RS14455	COG0527	aspartate kinase activity
L6426_RS14465	COG1368	sulfuric ester hydrolase activity
L6426_RS14470	COG0393	Putative heavy-metal-binding
L6426_RS14475	COG1252	NADH dehydrogenase
L6426_RS14480	COG3150	esterase
L6426_RS14485	COG1164	Oligoendopeptidase f
L6426_RS14490	COG1164	Oligoendopeptidase f
L6426_RS14495	COG2354	Protein conserved in bacteria
L6426_RS14525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6426_RS14530	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6426_RS14565	COG0537	adenosine 5'-monophosphoramidase activity
L6426_RS14580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L6426_RS14600	COG1301	dicarboxylic acid transport
L6426_RS14610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L6426_RS14615	COG0861	Integral membrane protein TerC family
L6426_RS14625	COG0444	Belongs to the ABC transporter superfamily
L6426_RS14630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6426_RS14635	COG0601	transmembrane transport
L6426_RS14645	COG2095	MarC family integral membrane protein
L6426_RS14650	COG1454	alcohol dehydrogenase
L6426_RS14650	COG1012	belongs to the aldehyde dehydrogenase family
L6426_RS14660	COG3275	phosphorelay sensor kinase activity
L6426_RS14665	COG3279	Response regulator of the LytR AlgR family
L6426_RS14670	COG1966	Carbon starvation protein
L6426_RS14675	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
L6426_RS14675	COG3264	Mechanosensitive ion channel
L6426_RS14685	COG1566	PFAM secretion protein HlyD family protein
L6426_RS14690	COG1061	Type III restriction enzyme res subunit
L6426_RS14695	COG2027	D-alanyl-D-alanine carboxypeptidase
L6426_RS14700	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L6426_RS14710	COG0436	Aminotransferase
L6426_RS14720	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L6426_RS14745	COG0697	spore germination
L6426_RS14755	COG0675	Transposase, IS605 OrfB family
L6426_RS14760	COG4657	Part of a membrane complex involved in electron transport
L6426_RS14765	COG2878	Part of a membrane complex involved in electron transport
L6426_RS14775	COG4658	electron transport chain
L6426_RS14780	COG4659	FMN binding
L6426_RS14785	COG4660	Part of a membrane complex involved in electron transport
L6426_RS14790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L6426_RS14795	COG0346	lactoylglutathione lyase activity
L6426_RS14815	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L6426_RS14825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6426_RS14860	COG1334	flagellar protein FlaG
L6426_RS14865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L6426_RS14880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6426_RS14880	COG0301	tRNA thio-modification
L6426_RS14890	COG4953	penicillin-binding protein 1C
L6426_RS14895	COG2373	Large extracellular alpha-helical protein
L6426_RS14900	COG0446	pyridine nucleotide-disulphide oxidoreductase
L6426_RS14910	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L6426_RS14920	COG4160	amino acid transport
L6426_RS14930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6426_RS14940	COG2431	L-lysine efflux transmembrane transporter activity
L6426_RS14945	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L6426_RS14950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6426_RS14970	COG1393	Belongs to the ArsC family
L6426_RS14980	COG4783	chaperone-mediated protein folding
L6426_RS14985	COG0425	Belongs to the sulfur carrier protein TusA family
L6426_RS15000	COG0596	Alpha beta hydrolase
L6426_RS15010	COG3842	ATPase activity
L6426_RS15015	COG3833	ABC-type maltose transport systems, permease component
L6426_RS15020	COG1175	transmembrane transport
L6426_RS15030	COG3081	Nucleoid-associated protein
L6426_RS15035	COG3082	Protein of unknown function (DUF1414)
L6426_RS15040	COG3083	sulfuric ester hydrolase activity
L6426_RS15045	COG4206	TonB-dependent receptor
L6426_RS15075	COG4574	serine-type endopeptidase inhibitor activity
L6426_RS15080	COG3085	chromosome segregation
L6426_RS15090	COG0287	Prephenate dehydrogenase
L6426_RS15090	COG1605	Chorismate mutase
L6426_RS15095	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L6426_RS15100	COG0584	glycerophosphoryl diester phosphodiesterase
L6426_RS15110	COG1349	DNA-binding transcription factor activity
L6426_RS15115	COG2271	Major facilitator Superfamily
L6426_RS15120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L6426_RS15125	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L6426_RS15130	COG0583	DNA-binding transcription factor activity
L6426_RS15150	COG0656	L-ascorbic acid biosynthetic process
L6426_RS15155	COG2814	Major facilitator Superfamily
L6426_RS15165	COG1294	oxidase, subunit
L6426_RS15175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6426_RS15185	COG2979	Protein of unknown function (DUF533)
L6426_RS15190	COG1607	acyl-coa hydrolase
L6426_RS15205	COG0583	DNA-binding transcription factor activity
L6426_RS15215	COG2807	transmembrane transport
L6426_RS15220	COG1187	pseudouridine synthase activity
L6426_RS15225	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L6426_RS15235	COG0675	Transposase, IS605 OrfB family
L6426_RS15265	COG1061	Type III restriction enzyme res subunit
L6426_RS15290	COG1166	arginine decarboxylase activity
L6426_RS15295	COG2195	Cleaves the N-terminal amino acid of tripeptides
L6426_RS15310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L6426_RS15325	COG0583	DNA-binding transcription factor activity
L6426_RS15335	COG2759	Belongs to the formate--tetrahydrofolate ligase family
L6426_RS15340	COG0840	transmembrane signaling receptor activity
L6426_RS15345	COG0302	gtp cyclohydrolase
L6426_RS15355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6426_RS15370	COG2267	carboxylic ester hydrolase activity
L6426_RS15375	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L6426_RS15390	COG0314	molybdopterin synthase activity
L6426_RS15395	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
L6426_RS15400	COG0315	cyclic pyranopterin monophosphate synthase activity
L6426_RS15405	COG0521	Mo-molybdopterin cofactor biosynthetic process
L6426_RS15410	COG3005	denitrification pathway
L6426_RS15420	COG0348	domain, Protein
L6426_RS15425	COG0437	4 iron, 4 sulfur cluster binding
L6426_RS15430	COG0243	molybdopterin cofactor binding
L6426_RS15440	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L6426_RS15440	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
L6426_RS15445	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L6426_RS15450	COG3850	Histidine kinase
L6426_RS15455	COG2197	response regulator
L6426_RS15480	COG0391	Required for morphogenesis under gluconeogenic growth conditions
L6426_RS15490	COG0121	glutamine amidotransferase
L6426_RS15495	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L6426_RS15500	COG1960	acyl-CoA dehydrogenase activity
L6426_RS15530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L6426_RS15535	COG0328	RNA-DNA hybrid ribonuclease activity
L6426_RS15540	COG2226	methyltransferase
L6426_RS15545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6426_RS15555	COG0741	lytic transglycosylase activity
L6426_RS15555	COG1388	LysM domain
L6426_RS15570	COG1607	acyl-coa hydrolase
L6426_RS15585	COG0741	lytic transglycosylase activity
L6426_RS15595	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L6426_RS15620	COG2911	Protein conserved in bacteria
L6426_RS15625	COG0729	surface antigen
L6426_RS15635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6426_RS15645	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L6426_RS15650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L6426_RS15655	COG4134	Bacterial extracellular solute-binding protein
L6426_RS15670	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L6426_RS15675	COG2951	lytic endotransglycosylase activity
L6426_RS15680	COG1846	Transcriptional regulator
L6426_RS15690	COG0033	Phosphoglucomutase
L6426_RS15695	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
L6426_RS15700	COG0596	Alpha beta hydrolase
L6426_RS15715	COG0716	FMN binding
L6426_RS15725	COG0735	belongs to the Fur family
L6426_RS15730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L6426_RS15740	COG1263	PTS System
L6426_RS15740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6426_RS15740	COG2190	(PTS) system
L6426_RS15745	COG0363	glucosamine-6-phosphate deaminase activity
L6426_RS15750	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L6426_RS15755	COG1940	carbohydrate kinase activity
L6426_RS15755	COG1846	Transcriptional regulator
L6426_RS15760	COG2194	sulfuric ester hydrolase activity
L6426_RS15765	COG0217	transcriptional regulatory protein
L6426_RS15770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L6426_RS15775	COG1801	Protein of unknown function DUF72
L6426_RS15780	COG4106	trans-aconitate 2-methyltransferase activity
L6426_RS15785	COG0500	methyltransferase
L6426_RS15805	COG0583	DNA-binding transcription factor activity
L6426_RS15810	COG0791	NLP P60 protein
L6426_RS15825	COG1309	transcriptional regulator
L6426_RS15835	COG1454	alcohol dehydrogenase
L6426_RS15860	COG0534	Mate efflux family protein
L6426_RS15870	COG2841	Protein conserved in bacteria
L6426_RS15890	COG0674	pyruvate-flavodoxin oxidoreductase activity
L6426_RS15890	COG1013	pyruvate-flavodoxin oxidoreductase activity
L6426_RS15890	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L6426_RS15890	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L6426_RS15900	COG0633	Ferredoxin
L6426_RS15900	COG3217	Mosc domain protein beta barrel domain protein
L6426_RS15900	COG0633	Ferredoxin
L6426_RS15900	COG3217	Mosc domain protein beta barrel domain protein
L6426_RS15905	COG0501	Belongs to the peptidase M48B family
L6426_RS15910	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
L6426_RS15915	COG1073	alpha beta
L6426_RS15915	COG2226	methyltransferase
L6426_RS15920	COG0156	8-amino-7-oxononanoate synthase activity
L6426_RS15925	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L6426_RS15945	COG0017	Asparaginyl-tRNA synthetase
L6426_RS15950	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
L6426_RS15960	COG1473	amidohydrolase
L6426_RS15965	COG3069	C4-dicarboxylate transmembrane transporter activity
L6426_RS15975	COG1393	Belongs to the ArsC family
L6426_RS15980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L6426_RS15985	COG1876	peptidase activity
L6426_RS15995	COG3263	regulation of cellular component size
L6426_RS16005	COG1280	lysine exporter protein (LysE YggA)
L6426_RS16035	COG1957	nucleoside hydrolase
L6426_RS16040	COG0564	pseudouridine synthase activity
L6426_RS16050	COG1454	alcohol dehydrogenase
L6426_RS16055	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L6426_RS16060	COG0702	epimerase
L6426_RS16065	COG2914	Belongs to the UPF0125 (RnfH) family
L6426_RS16070	COG2867	negative regulation of translational initiation
L6426_RS16075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L6426_RS16095	COG0800	Aldolase
L6426_RS16110	COG3153	acetyltransferase
L6426_RS16140	COG0259	pyridoxamine-phosphate oxidase activity
L6426_RS16155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L6426_RS16155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L6426_RS16160	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L6426_RS16185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6426_RS16190	COG1138	Cytochrome C-type biogenesis protein
L6426_RS16195	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
L6426_RS16200	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6426_RS16205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6426_RS16210	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6426_RS16225	COG0835	chemotaxis
L6426_RS16235	COG1192	Involved in chromosome partitioning
L6426_RS16240	COG1360	Flagellar Motor Protein
L6426_RS16245	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6426_RS16250	COG2201	protein-glutamate methylesterase activity
L6426_RS16255	COG2198	Histidine kinase
L6426_RS16255	COG0784	Response regulator, receiver
L6426_RS16255	COG0643	Histidine kinase
L6426_RS16260	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
L6426_RS16285	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L6426_RS16295	COG1684	flagellar biosynthetic protein fliR
L6426_RS16350	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6426_RS16360	COG1677	Flagellar hook-basal body complex protein FliE
L6426_RS16375	COG1393	Belongs to the ArsC family
L6426_RS16380	COG0798	PFAM Bile acid sodium symporter
L6426_RS16385	COG0640	Transcriptional regulator
L6426_RS16395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L6426_RS16410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6426_RS16415	COG0444	Belongs to the ABC transporter superfamily
L6426_RS16420	COG4608	Belongs to the ABC transporter superfamily
L6426_RS16430	COG2971	BadF BadG BcrA BcrD
L6426_RS16440	COG0840	transmembrane signaling receptor activity
L6426_RS16460	COG3724	N-succinylarginine dihydrolase activity
L6426_RS16465	COG0616	signal peptide processing
L6426_RS16470	COG1028	Short-chain dehydrogenase reductase Sdr
L6426_RS16475	COG0583	DNA-binding transcription factor activity
L6426_RS16485	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L6426_RS16495	COG0583	DNA-binding transcription factor activity
L6426_RS16500	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L6426_RS16505	COG1881	PFAM PEBP family protein
L6426_RS16515	COG3408	Glycogen debranching enzyme
L6426_RS16515	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
L6426_RS16520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L6426_RS16525	COG0739	heme binding
L6426_RS16530	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L6426_RS16555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L6426_RS16565	COG3091	SprT-like family
L6426_RS16575	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L6426_RS16580	COG0189	ligase activity
L6426_RS16590	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L6426_RS16610	COG1115	amino acid carrier protein
L6426_RS16615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L6426_RS16630	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L6426_RS16640	COG1301	dicarboxylic acid transport
L6426_RS16645	COG2877	3-deoxy-8-phosphooctulonate synthase activity
L6426_RS16650	COG2912	Transglutaminase-like superfamily
L6426_RS16660	COG2890	protein-(glutamine-N5) methyltransferase activity
L6426_RS16665	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L6426_RS16670	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
L6426_RS16675	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L6426_RS16680	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
L6426_RS16690	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L6426_RS16695	COG0193	aminoacyl-tRNA hydrolase activity
L6426_RS16700	COG0012	GTP binding
L6426_RS16745	COG0490	domain, Protein
L6426_RS16745	COG0471	metal ion transport
L6426_RS16770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L6426_RS16815	COG1012	belongs to the aldehyde dehydrogenase family
L6426_RS16825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L6426_RS16840	COG0180	Tryptophanyl-tRNA synthetase
L6426_RS16845	COG0546	phosphoglycolate phosphatase activity
L6426_RS16850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L6426_RS16855	COG0338	D12 class N6 adenine-specific DNA methyltransferase
L6426_RS16865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L6426_RS16870	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L6426_RS16900	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
L6426_RS16905	COG0583	DNA-binding transcription factor activity
L6426_RS16920	COG0583	DNA-binding transcription factor activity
L6426_RS16930	COG0739	heme binding
L6426_RS16940	COG3264	Mechanosensitive ion channel
L6426_RS16940	COG1511	domain protein
L6426_RS16945	COG0584	glycerophosphoryl diester phosphodiesterase
L6426_RS16955	COG1053	succinate dehydrogenase
L6426_RS16960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L6426_RS16965	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
L6426_RS16970	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
L6426_RS16985	COG3214	Protein conserved in bacteria
L6426_RS16990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L6426_RS17010	COG0300	oxidoreductase activity
L6426_RS17030	COG0189	ligase activity
L6426_RS17030	COG4067	protein conserved in archaea
L6426_RS17035	COG0516	GMP reductase activity
L6426_RS17045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L6426_RS17050	COG2011	ABC-type metal ion transport system permease component
L6426_RS17060	COG1464	Belongs to the NlpA lipoprotein family
L6426_RS17075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L6426_RS17085	COG2199	diguanylate cyclase activity
L6426_RS17095	COG2199	diguanylate cyclase activity
L6426_RS17100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L6426_RS17115	COG1335	isochorismatase
L6426_RS17120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L6426_RS17125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L6426_RS17130	COG1702	phosphate starvation-inducible protein PhoH
L6426_RS17135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L6426_RS17140	COG4535	Mg2 and Co2 transporter CorC
L6426_RS17145	COG0815	Transfers the fatty acyl group on membrane lipoproteins
L6426_RS17150	COG2888	peptidyl-tyrosine sulfation
L6426_RS17155	COG0495	leucyl-tRNA aminoacylation
L6426_RS17170	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L6426_RS17175	COG0799	negative regulation of ribosome biogenesis
L6426_RS17180	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
L6426_RS17185	COG0768	penicillin binding
L6426_RS17190	COG0772	Belongs to the SEDS family
L6426_RS17195	COG2951	lytic endotransglycosylase activity
L6426_RS17200	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L6426_RS17205	COG1686	Belongs to the peptidase S11 family
L6426_RS17210	COG2921	Belongs to the UPF0250 family
L6426_RS17215	COG0321	lipoyl(octanoyl) transferase activity
L6426_RS17220	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L6426_RS17230	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L6426_RS17245	COG0789	Transcriptional regulator
L6426_RS17250	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L6426_RS17260	COG1970	mechanosensitive ion channel activity
L6426_RS17265	COG4974	Belongs to the 'phage' integrase family
L6426_RS17275	COG0312	modulator of DNA gyrase
L6426_RS17280	COG0312	modulator of DNA gyrase
L6426_RS17295	COG0826	peptidase U32
L6426_RS17300	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L6426_RS17305	COG1422	Protein of unknown function (DUF1090)
L6426_RS17310	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L6426_RS17315	COG2211	Major facilitator Superfamily
L6426_RS17320	COG1185	polyribonucleotide nucleotidyltransferase activity
L6426_RS17325	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L6426_RS17330	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L6426_RS17335	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L6426_RS17340	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L6426_RS17345	COG0195	Participates in both transcription termination and antitermination
L6426_RS17350	COG0779	Required for maturation of 30S ribosomal subunits
L6426_RS17365	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L6426_RS17370	COG0149	triose-phosphate isomerase activity
L6426_RS17375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L6426_RS17380	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L6426_RS17390	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
L6426_RS17395	COG1534	Rna-binding protein
L6426_RS17410	COG1360	Flagellar Motor Protein
L6426_RS17415	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6426_RS17420	COG1722	exodeoxyribonuclease VII activity
L6426_RS17425	COG0142	geranyltranstransferase activity
L6426_RS17430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L6426_RS17435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6426_RS17440	COG0601	transmembrane transport
L6426_RS17450	COG4172	Belongs to the ABC transporter superfamily
L6426_RS17455	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L6426_RS17460	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L6426_RS17465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L6426_RS17470	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L6426_RS17485	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L6426_RS17485	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L6426_RS17490	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L6426_RS17500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L6426_RS17510	COG3381	protein complex oligomerization
L6426_RS17525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6426_RS17530	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L6426_RS17535	COG0511	ligase activity, forming carbon-carbon bonds
L6426_RS17540	COG0439	Biotin carboxylase
L6426_RS17545	COG3924	membrane
L6426_RS17550	COG4145	pantothenate transmembrane transporter activity
L6426_RS17555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6426_RS17555	COG1263	PTS System
L6426_RS17555	COG2190	(PTS) system
L6426_RS17560	COG0583	DNA-binding transcription factor activity
L6426_RS17565	COG0604	alcohol dehydrogenase
L6426_RS17570	COG2264	protein methyltransferase activity
L6426_RS17590	COG0778	Nitroreductase
L6426_RS17595	COG0446	pyridine nucleotide-disulphide oxidoreductase
L6426_RS17595	COG1902	pentaerythritol trinitrate reductase activity
L6426_RS17600	COG0616	signal peptide processing
L6426_RS17620	COG3139	Protein of unknown function (DUF1315)
L6426_RS17625	COG0252	asparaginase activity
L6426_RS17630	COG0786	glutamate:sodium symporter activity
L6426_RS17645	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L6426_RS17650	COG0384	phenazine biosynthesis protein PhzF
L6426_RS17655	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L6426_RS17660	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6426_RS17665	COG0175	sulfate reduction
L6426_RS17670	COG2113	Glycine betaine
L6426_RS17675	COG4176	ABC-type proline glycine betaine transport system permease component
L6426_RS17680	COG4175	Glycine betaine
L6426_RS17690	COG3610	response to peptide
L6426_RS17695	COG2966	Psort location CytoplasmicMembrane, score
L6426_RS17705	COG0521	Mo-molybdopterin cofactor biosynthetic process
L6426_RS17730	COG2313	pseudouridylate synthase activity
L6426_RS17735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6426_RS17740	COG2146	nitrite reductase [NAD(P)H] activity
L6426_RS17740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6426_RS17745	COG2146	nitrite reductase [NAD(P)H] activity
L6426_RS17745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6426_RS17750	COG1116	anion transmembrane transporter activity
L6426_RS17755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6426_RS17760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6426_RS17760	COG1116	anion transmembrane transporter activity
L6426_RS17770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L6426_RS17770	COG1648	precorrin-2 dehydrogenase activity
L6426_RS17775	COG0243	molybdopterin cofactor binding
L6426_RS17800	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
L6426_RS17815	COG1073	alpha beta
L6426_RS17820	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
L6426_RS17825	COG2195	Cleaves the N-terminal amino acid of tripeptides
L6426_RS17830	COG4608	Belongs to the ABC transporter superfamily
L6426_RS17835	COG0444	Belongs to the ABC transporter superfamily
L6426_RS17845	COG4239	(ABC) transporter, permease
L6426_RS17850	COG4174	ABC transporter (Permease)
L6426_RS17860	COG4206	TonB-dependent receptor
L6426_RS17870	COG0811	peptide transport
L6426_RS17875	COG0811	peptide transport
L6426_RS17880	COG0848	biopolymer transport protein
L6426_RS17930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L6426_RS17935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L6426_RS17940	COG0840	transmembrane signaling receptor activity
L6426_RS17950	COG1278	Cold shock
L6426_RS18000	COG0629	single-stranded DNA binding
L6426_RS18055	COG3039	Transposase
L6426_RS18110	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
L6426_RS18335	COG2003	Belongs to the UPF0758 family
L6426_RS18385	COG0640	Transcriptional regulator
L6426_RS18410	COG0798	PFAM Bile acid sodium symporter
L6426_RS18420	COG0431	NADPH-dependent FMN reductase
L6426_RS18425	COG1595	DNA-templated transcription, initiation
L6426_RS18435	COG3039	Transposase
L6426_RS18450	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L6426_RS18470	COG3220	belongs to the UPF0276 family
L6426_RS18500	COG0785	Cytochrome C biogenesis protein
L6426_RS18505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6426_RS18510	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L6426_RS18515	COG0659	secondary active sulfate transmembrane transporter activity
L6426_RS18520	COG0589	response to stress
L6426_RS18525	COG0583	DNA-binding transcription factor activity
L6426_RS18530	COG1396	sequence-specific DNA binding
L6426_RS18540	COG0582	viral genome integration into host DNA
L6426_RS18580	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L6426_RS18585	COG1162	GTPase activity
L6426_RS18590	COG0688	phosphatidylethanolamine metabolic process
L6426_RS18595	COG4628	conserved protein (DUF2132)
L6426_RS18615	COG5001	Diguanylate cyclase
L6426_RS18615	COG3300	MHYT domain
L6426_RS18620	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
L6426_RS18645	COG1132	(ABC) transporter
L6426_RS18660	COG2066	Belongs to the glutaminase family
L6426_RS18665	COG3171	Protein conserved in bacteria
L6426_RS18670	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L6426_RS18675	COG2234	aminopeptidase activity
L6426_RS18675	COG4935	Belongs to the peptidase S8 family
L6426_RS18680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6426_RS18685	COG2200	EAL domain
L6426_RS18690	COG1090	epimerase
L6426_RS18695	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L6426_RS18700	COG4181	ATPase activity
L6426_RS18705	COG2755	lipolytic protein G-D-S-L family
L6426_RS18710	COG0835	chemotaxis
L6426_RS18710	COG0784	Response regulator, receiver
L6426_RS18720	COG0517	IMP dehydrogenase activity
L6426_RS18720	COG0516	GMP reductase activity
L6426_RS18725	COG0488	(ABC) transporter
L6426_RS18735	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L6426_RS18790	COG0789	Transcriptional regulator
L6426_RS18800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6426_RS18810	COG0668	transmembrane transport
L6426_RS18820	COG2731	YhcH YjgK YiaL family protein
L6426_RS18830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6426_RS18835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6426_RS18840	COG3227	Zinc metalloprotease (Elastase)
L6426_RS18845	COG0583	DNA-binding transcription factor activity
L6426_RS18850	COG0477	Major facilitator Superfamily
L6426_RS18870	COG2985	domain, Protein
L6426_RS18870	COG0569	domain protein
L6426_RS18875	COG1272	protein, Hemolysin III
L6426_RS18880	COG0076	glutamate decarboxylase activity
L6426_RS18885	COG2917	probably involved in intracellular septation
L6426_RS18890	COG2350	Protein conserved in bacteria
L6426_RS18900	COG1555	photosystem II stabilization
L6426_RS18905	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L6426_RS18910	COG3104	oligopeptide transport
L6426_RS18915	COG0745	RESPONSE REGULATOR receiver
L6426_RS18945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6426_RS18960	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L6426_RS18985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6426_RS18990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6426_RS19100	COG2003	Belongs to the UPF0758 family
L6426_RS19150	COG2003	Belongs to the UPF0758 family
L6426_RS19205	COG3311	Transcriptional regulator
L6426_RS19220	COG1280	lysine exporter protein (LysE YggA)
L6426_RS19245	COG0316	Belongs to the HesB IscA family
L6426_RS19255	COG0038	chloride channel
L6426_RS19260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L6426_RS19275	COG0671	phosphoesterase, PA-phosphatase related
L6426_RS19285	COG0583	DNA-binding transcription factor activity
L6426_RS19290	COG2076	Multidrug Resistance protein
L6426_RS19300	COG0346	lactoylglutathione lyase activity
L6426_RS19305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6426_RS19310	COG1643	Atp-dependent helicase
L6426_RS19320	COG1489	DNA binding
L6426_RS19325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L6426_RS19330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L6426_RS19340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L6426_RS19345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
L6426_RS19350	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
L6426_RS19360	COG0842	Transport permease protein
L6426_RS19365	COG1131	(ABC) transporter
L6426_RS19380	COG0163	prenyltransferase activity
L6426_RS19385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L6426_RS19390	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L6426_RS19405	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
L6426_RS19420	COG1136	(ABC) transporter
L6426_RS19470	COG2801	Transposase and inactivated derivatives
L6426_RS19475	COG0529	Catalyzes the synthesis of activated sulfate
L6426_RS19480	COG0471	metal ion transport
L6426_RS19480	COG3273	potassium ion transport
L6426_RS19485	COG2895	sulfate adenylyltransferase (ATP) activity
L6426_RS19490	COG0175	sulfate reduction
L6426_RS19495	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L6426_RS19495	COG1648	precorrin-2 dehydrogenase activity
L6426_RS19500	COG0330	HflC and HflK could
L6426_RS19505	COG1585	Membrane protein implicated in regulation of membrane protease activity
L6426_RS19515	COG0673	inositol 2-dehydrogenase activity
L6426_RS19525	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L6426_RS19530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L6426_RS19535	COG3036	rescue of stalled ribosome
L6426_RS19550	COG0138	bifunctional purine biosynthesis protein purh
L6426_RS19555	COG0151	Belongs to the GarS family
L6426_RS19585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L6426_RS19590	COG0358	DNA primase activity
L6426_RS19595	COG1610	YqeY-like protein
L6426_RS19600	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L6426_RS19605	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L6426_RS19615	COG4942	peptidase
L6426_RS19615	COG1388	LysM domain
L6426_RS19620	COG1238	metal cluster binding
L6426_RS19625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L6426_RS19630	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L6426_RS19635	COG0585	pseudouridine synthase activity
L6426_RS19645	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L6426_RS19650	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L6426_RS19655	COG0148	phosphopyruvate hydratase activity
L6426_RS19660	COG0504	CTP synthase activity
L6426_RS19665	COG3956	TIGRFAM MazG family protein
L6426_RS19670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L6426_RS19675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L6426_RS19685	COG4807	Protein conserved in bacteria
L6426_RS19690	COG3023	N-Acetylmuramoyl-L-alanine amidase
L6426_RS19695	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L6426_RS19700	COG1381	Involved in DNA repair and RecF pathway recombination
L6426_RS19710	COG0571	ribonuclease III activity
L6426_RS19715	COG0681	Belongs to the peptidase S26 family
L6426_RS19720	COG0481	GTPase activity
L6426_RS19740	COG1595	DNA-templated transcription, initiation
L6426_RS19745	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
L6426_RS19755	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L6426_RS19765	COG0583	DNA-binding transcription factor activity
L6426_RS19800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6426_RS19810	COG0126	phosphoglycerate kinase activity
L6426_RS19815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L6426_RS19820	COG1940	carbohydrate kinase activity
L6426_RS19825	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L6426_RS19830	COG2816	NAD+ diphosphatase activity
L6426_RS19835	COG4991	sh3 domain protein
L6426_RS19840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6426_RS19855	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L6426_RS19860	COG1028	Short-chain dehydrogenase reductase Sdr
L6426_RS19875	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L6426_RS19880	COG0765	amino acid transport
L6426_RS19885	COG0765	amino acid transport
L6426_RS19890	COG1126	abc transporter atp-binding protein
L6426_RS19895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6426_RS19900	COG3174	membrane
L6426_RS19905	COG0110	maltose O-acetyltransferase activity
L6426_RS19945	COG0583	DNA-binding transcription factor activity
L6426_RS19950	COG0165	Argininosuccinate lyase
L6426_RS19955	COG0137	argininosuccinate synthase activity
L6426_RS19965	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L6426_RS19970	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L6426_RS19980	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
L6426_RS19990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L6426_RS20025	COG0583	DNA-binding transcription factor activity
L6426_RS20030	COG1380	Effector of murein hydrolase LrgA
L6426_RS20035	COG1346	cytolysis
L6426_RS20040	COG0460	homoserine dehydrogenase
L6426_RS20040	COG0527	aspartate kinase activity
L6426_RS20045	COG0626	cystathionine gamma-synthase activity
L6426_RS20060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6426_RS20065	COG0814	amino acid
L6426_RS20070	COG1218	3'(2'),5'-bisphosphate nucleotidase
L6426_RS20075	COG0494	nUDIX hydrolase
L6426_RS20080	COG1011	Hydrolase
L6426_RS20085	COG1902	pentaerythritol trinitrate reductase activity
L6426_RS20095	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L6426_RS20110	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
L6426_RS20120	COG3156	type II secretion system protein K
L6426_RS20130	COG4795	General secretion pathway protein
L6426_RS20135	COG2165	general secretion pathway protein
L6426_RS20145	COG2165	general secretion pathway protein
L6426_RS20150	COG1459	type II secretion system
L6426_RS20155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L6426_RS20165	COG3031	protein transport across the cell outer membrane
L6426_RS20175	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L6426_RS20180	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
L6426_RS20195	COG0456	acetyltransferase
L6426_RS20200	COG3133	Outer membrane lipoprotein
L6426_RS20205	COG3025	triphosphatase activity
L6426_RS20210	COG1392	Phosphate transport regulator
L6426_RS20215	COG0306	phosphate transporter
L6426_RS20220	COG0617	tRNA 3'-terminal CCA addition
L6426_RS20225	COG3409	Peptidoglycan-binding domain 1 protein
L6426_RS20225	COG3267	Type II secretory pathway component ExeA
L6426_RS20235	COG1194	a g-specific adenine glycosylase
L6426_RS20240	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
L6426_RS20255	COG3240	lipase activity
L6426_RS20265	COG3009	Protein conserved in bacteria
L6426_RS20270	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L6426_RS20270	COG3008	intermembrane lipid transfer
L6426_RS20275	COG2995	paraquat-inducible protein a
L6426_RS20285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L6426_RS20290	COG4251	negative regulation of phosphorylation
L6426_RS20290	COG2203	Gaf domain
L6426_RS20290	COG3706	GGDEF domain
L6426_RS20290	COG5001	Diguanylate cyclase
L6426_RS20295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L6426_RS20300	COG2813	Specifically methylates the guanine in position
L6426_RS20305	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L6426_RS20310	COG0297	glycogen (starch) synthase activity
L6426_RS20350	COG1757	Na H antiporter
L6426_RS20355	COG0583	DNA-binding transcription factor activity
L6426_RS20360	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L6426_RS20365	COG3842	ATPase activity
L6426_RS20370	COG1176	ABC-type spermidine putrescine transport system, permease component I
L6426_RS20375	COG1177	transmembrane transport
L6426_RS20380	COG1012	belongs to the aldehyde dehydrogenase family
L6426_RS20385	COG0109	protoheme IX farnesyltransferase activity
L6426_RS20415	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
L6426_RS20425	COG1565	acr, cog1565
L6426_RS20425	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L6426_RS20430	COG1444	tRNA N-acetyltransferase activity
L6426_RS20450	COG1803	Methylglyoxal synthase
L6426_RS20465	COG0252	asparaginase activity
L6426_RS20485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6426_RS20485	COG1263	PTS System
L6426_RS20490	COG0366	Alpha amylase catalytic
L6426_RS20495	COG0110	maltose O-acetyltransferase activity
L6426_RS20500	COG1522	sequence-specific DNA binding
L6426_RS20505	COG5006	permease, DMT superfamily
L6426_RS20530	COG3068	Protein conserved in bacteria
L6426_RS20540	COG0739	heme binding
L6426_RS20560	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
L6426_RS20565	COG1121	(ABC) transporter
L6426_RS20570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L6426_RS20575	COG0583	DNA-binding transcription factor activity
L6426_RS20585	COG1573	uracil-dna glycosylase
L6426_RS20590	COG2962	Rard protein
L6426_RS20595	COG2827	Endonuclease containing a URI domain
L6426_RS20610	COG1842	Phage shock protein A
L6426_RS20615	COG0204	Acyl-transferase
L6426_RS20635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6426_RS20645	COG0484	heat shock protein binding
L6426_RS20695	COG1289	transmembrane transporter activity
L6426_RS20700	COG1566	PFAM secretion protein HlyD family protein
L6426_RS20715	COG1051	belongs to the nudix hydrolase family
L6426_RS20720	COG3150	esterase
L6426_RS20730	COG3151	Protein conserved in bacteria
L6426_RS20735	COG0494	nUDIX hydrolase
L6426_RS20740	COG1538	Outer membrane efflux protein
L6426_RS20745	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L6426_RS20745	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L6426_RS20750	COG1560	Kdo2-lipid A biosynthetic process
L6426_RS20765	COG2771	luxR family
L6426_RS20780	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
L6426_RS20785	COG2213	PTS system mannitol-specific
L6426_RS20785	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6426_RS20790	COG0246	Mannitol dehydrogenase
L6426_RS20795	COG3722	fumarate hydratase activity
L6426_RS20800	COG3263	regulation of cellular component size
L6426_RS20820	COG1671	Belongs to the UPF0178 family
L6426_RS20835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6426_RS20840	COG0513	Belongs to the DEAD box helicase family
L6426_RS20860	COG1575	Belongs to the MenA family. Type 1 subfamily
L6426_RS20865	COG1169	isochorismate synthase
L6426_RS20870	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
L6426_RS20875	COG0596	Alpha beta hydrolase
L6426_RS20880	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
L6426_RS20890	COG0318	PFAM AMP-dependent synthetase and ligase
L6426_RS20895	COG3291	Pkd domain containing protein
L6426_RS20900	COG2949	membrane
L6426_RS20905	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6426_RS20915	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
L6426_RS20945	COG2873	o-acetylhomoserine
L6426_RS20955	COG1979	alcohol dehydrogenase
L6426_RS20970	COG4221	oxidoreductase activity
L6426_RS20990	COG1285	pathogenesis
L6426_RS21005	COG1368	sulfuric ester hydrolase activity
L6426_RS21010	COG1522	sequence-specific DNA binding
L6426_RS21020	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
L6426_RS21030	COG1058	Belongs to the CinA family
L6426_RS21030	COG1546	Belongs to the CinA family
L6426_RS21035	COG1988	membrane-bound metal-dependent
L6426_RS21050	COG0561	phosphatase activity
L6426_RS21065	COG1011	Hydrolase
L6426_RS21080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L6426_RS21085	COG0019	diaminopimelate decarboxylase activity
L6426_RS21095	COG1965	Belongs to the frataxin family
L6426_RS21100	COG0400	carboxylic ester hydrolase activity
L6426_RS21105	COG3072	Adenylate cyclase
L6426_RS21110	COG0181	hydroxymethylbilane synthase activity
L6426_RS21115	COG1587	Uroporphyrinogen-III synthase
L6426_RS21120	COG2959	enzyme of heme biosynthesis
L6426_RS21125	COG3071	HemY protein
L6426_RS21135	COG0312	modulator of DNA gyrase
L6426_RS21140	COG3028	Belongs to the UPF0307 family
L6426_RS21150	COG2926	Belongs to the UPF0265 family
L6426_RS21180	COG1396	sequence-specific DNA binding
L6426_RS21185	COG3135	benzoate transporter
L6426_RS21210	COG0840	transmembrane signaling receptor activity
L6426_RS21215	COG3047	cAMP biosynthetic process
L6426_RS21220	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L6426_RS21225	COG2197	response regulator
L6426_RS21260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L6426_RS21295	COG1396	sequence-specific DNA binding
L6426_RS21315	COG1278	Cold shock
L6426_RS21345	COG3706	GGDEF domain
L6426_RS21350	COG0347	Belongs to the P(II) protein family
L6426_RS21355	COG0004	ammonium transporteR
L6426_RS21370	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L6426_RS21375	COG1074	ATP-dependent DNA helicase activity
L6426_RS21380	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L6426_RS21385	COG2259	Doxx family
L6426_RS21390	COG1741	Belongs to the pirin family
L6426_RS21400	COG0583	DNA-binding transcription factor activity
L6426_RS21425	COG1175	transmembrane transport
L6426_RS21435	COG3842	ATPase activity
L6426_RS21465	COG0456	acetyltransferase
L6426_RS21470	COG0753	catalase activity
L6426_RS21490	COG0494	nUDIX hydrolase
L6426_RS21495	COG0628	permease
L6426_RS21505	COG2957	Belongs to the agmatine deiminase family
L6426_RS21520	COG2957	Belongs to the agmatine deiminase family
L6426_RS21525	COG0583	DNA-binding transcription factor activity
L6426_RS21540	COG1461	Dihydroxyacetone kinase
L6426_RS21545	COG2376	Dihydroxyacetone kinase
L6426_RS21550	COG2252	PERMEase
L6426_RS21555	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
L6426_RS21590	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L6426_RS21595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L6426_RS21600	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L6426_RS21605	COG0049	tRNA binding
L6426_RS21610	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L6426_RS21615	COG2168	tRNA wobble position uridine thiolation
L6426_RS21625	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L6426_RS21630	COG0251	oxidation-reduction process
L6426_RS21635	COG2964	Protein conserved in bacteria
L6426_RS21640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L6426_RS21645	COG0085	RNA polymerase activity
L6426_RS21650	COG0222	ribosome binding
L6426_RS21655	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L6426_RS21660	COG0081	regulation of translation
L6426_RS21665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L6426_RS21670	COG0250	Participates in transcription elongation, termination and antitermination
L6426_RS21685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L6426_RS21710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L6426_RS21715	COG0569	domain protein
L6426_RS21720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6426_RS21725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L6426_RS21730	COG3005	denitrification pathway
L6426_RS21735	COG0243	molybdopterin cofactor binding
L6426_RS21770	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L6426_RS21780	COG2204	response regulator
L6426_RS21790	COG2205	protein histidine kinase activity
L6426_RS21810	COG0517	IMP dehydrogenase activity
L6426_RS21810	COG0516	GMP reductase activity
L6426_RS21820	COG1522	sequence-specific DNA binding
L6426_RS21825	COG2502	aspartate--ammonia ligase
L6426_RS21840	COG0583	DNA-binding transcription factor activity
L6426_RS21845	COG0542	response to heat
L6426_RS21855	COG0564	pseudouridine synthase activity
L6426_RS21860	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L6426_RS21865	COG3681	Belongs to the UPF0597 family
L6426_RS21870	COG2964	Protein conserved in bacteria
L6426_RS21875	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
L6426_RS21880	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
L6426_RS21885	COG1979	alcohol dehydrogenase
L6426_RS21890	COG2207	Transcriptional regulator
L6426_RS21895	COG3040	lipid binding
L6426_RS21915	COG0583	DNA-binding transcription factor activity
L6426_RS21935	COG0540	Belongs to the ATCase OTCase family
L6426_RS21940	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
L6426_RS21945	COG1438	arginine binding
L6426_RS21950	COG1288	antiporter activity
L6426_RS21955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L6426_RS21995	COG3250	beta-galactosidase activity
L6426_RS22000	COG1609	Transcriptional regulator
L6426_RS22005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L6426_RS22015	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
L6426_RS22020	COG2017	converts alpha-aldose to the beta-anomer
L6426_RS22025	COG0667	Aldo Keto reductase
L6426_RS22030	COG1968	undecaprenyl-diphosphatase activity
L6426_RS22035	COG3806	Anti-sigma factor
L6426_RS22040	COG1595	DNA-templated transcription, initiation
L6426_RS22060	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
L6426_RS22065	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
L6426_RS22070	COG0477	Major facilitator Superfamily
L6426_RS22085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6426_RS22090	COG1131	(ABC) transporter
L6426_RS22095	COG0842	Transport permease protein
L6426_RS22100	COG0842	Transport permease protein
L6426_RS22105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6426_RS22120	COG2116	formate transmembrane transporter activity
L6426_RS22125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L6426_RS22125	COG1648	precorrin-2 dehydrogenase activity
L6426_RS22130	COG2239	Acts as a magnesium transporter
L6426_RS22135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L6426_RS22140	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
L6426_RS22150	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L6426_RS22160	COG0514	ATP-dependent DNA helicase (RecQ)
L6426_RS22165	COG0514	ATP-dependent DNA helicase (RecQ)
L6426_RS22170	COG2050	protein possibly involved in aromatic compounds catabolism
L6426_RS22185	COG2258	MOSC domain
L6426_RS22190	COG1177	transmembrane transport
L6426_RS22195	COG1176	ABC-type spermidine putrescine transport system, permease component I
L6426_RS22200	COG3842	ATPase activity
L6426_RS22220	COG0174	glutamine synthetase
L6426_RS22240	COG3045	CreA protein
L6426_RS22245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L6426_RS22250	COG0443	Heat shock 70 kDa protein
L6426_RS22265	COG0366	Alpha amylase catalytic
L6426_RS22275	COG4310	Domain of unknown function (DUF2172)
L6426_RS22310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L6426_RS22315	COG0745	RESPONSE REGULATOR receiver
L6426_RS22320	COG2205	protein histidine kinase activity
L6426_RS22330	COG0281	malic enzyme
L6426_RS22335	COG0702	epimerase
L6426_RS22340	COG0254	rRNA binding
L6426_RS22345	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L6426_RS22350	COG1309	transcriptional regulator
L6426_RS22370	COG0129	dihydroxy-acid dehydratase activity
L6426_RS22380	COG3978	acetolactate synthase activity
L6426_RS22390	COG0606	chelatase, subunit chli
L6426_RS22395	COG0204	Acyl-transferase
L6426_RS22400	COG0204	Acyl-transferase
L6426_RS22405	COG1683	Conserved Protein
L6426_RS22415	COG1335	isochorismatase
L6426_RS22425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L6426_RS22430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L6426_RS22440	COG3084	Protein conserved in bacteria
L6426_RS22445	COG2203	Gaf domain
L6426_RS22445	COG3706	GGDEF domain
L6426_RS22445	COG4251	negative regulation of phosphorylation
L6426_RS22445	COG5001	Diguanylate cyclase
L6426_RS22460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L6426_RS22465	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
L6426_RS22470	COG1561	YicC-like family, N-terminal region
L6426_RS22480	COG1519	Transferase
L6426_RS22485	COG0859	PFAM glycosyl transferase family 9
L6426_RS22490	COG0463	Glycosyl transferase, family 2
L6426_RS22495	COG0859	PFAM glycosyl transferase family 9
L6426_RS22500	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L6426_RS22505	COG2990	Protein conserved in bacteria
L6426_RS22510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L6426_RS22520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L6426_RS22525	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L6426_RS22530	COG2003	Belongs to the UPF0758 family
L6426_RS22535	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L6426_RS22540	COG0756	dUTP diphosphatase activity
L6426_RS22545	COG1309	transcriptional regulator
L6426_RS22560	COG0668	transmembrane transport
L6426_RS22570	COG0166	Belongs to the GPI family
L6426_RS22575	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L6426_RS22580	COG0583	DNA-binding transcription factor activity
L6426_RS22590	COG0045	succinate-CoA ligase (ADP-forming) activity
L6426_RS22590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6426_RS22590	COG1042	CoA-binding domain protein
L6426_RS22625	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
L6426_RS22630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6426_RS22635	COG1739	Uncharacterized protein family UPF0029
L6426_RS22640	COG0006	proline dipeptidase activity
L6426_RS22645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6426_RS22650	COG1024	Enoyl-CoA hydratase
L6426_RS22650	COG1250	3-hydroxyacyl-CoA dehydrogenase
L6426_RS22655	COG0183	Belongs to the thiolase family
L6426_RS22690	COG0425	Belongs to the sulfur carrier protein TusA family
L6426_RS22695	COG0251	oxidation-reduction process
L6426_RS22700	COG2885	chlorophyll binding
L6426_RS22710	COG1335	isochorismatase
L6426_RS22715	COG2818	Glycosylase
L6426_RS22720	COG0752	glycyl-tRNA synthetase alpha subunit
L6426_RS22725	COG0751	glycine-tRNA ligase activity
L6426_RS22740	COG3604	Transcriptional regulator
L6426_RS22745	COG0426	domain, Protein
L6426_RS22745	COG1773	rubredoxin
L6426_RS22750	COG0446	pyridine nucleotide-disulphide oxidoreductase
L6426_RS22760	COG0348	domain, Protein
L6426_RS22765	COG3033	Beta-eliminating lyase
L6426_RS22770	COG0814	amino acid
L6426_RS22775	COG0814	amino acid
L6426_RS22795	COG2203	Gaf domain
L6426_RS22795	COG3706	GGDEF domain
L6426_RS22795	COG4251	negative regulation of phosphorylation
L6426_RS22795	COG5001	Diguanylate cyclase
L6426_RS22805	COG1609	Transcriptional regulator
L6426_RS22845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6426_RS22860	COG2960	long-chain fatty acid transporting porin activity
L6426_RS22870	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
L6426_RS22885	COG3118	belongs to the thioredoxin family
L6426_RS22890	COG0513	Belongs to the DEAD box helicase family
L6426_RS22895	COG0248	Ppx GppA phosphatase
L6426_RS22905	COG0742	ribosomal rna small subunit methyltransferase
L6426_RS22925	COG0084	hydrolase, TatD family'
L6426_RS22930	COG0805	protein transport
L6426_RS22935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L6426_RS22940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L6426_RS22945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L6426_RS22950	COG3165	ubiquinone biosynthetic process from chorismate
L6426_RS22960	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L6426_RS22965	COG0402	S-adenosylhomocysteine deaminase activity
L6426_RS23000	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
L6426_RS23005	COG0848	biopolymer transport protein
L6426_RS23010	COG0811	peptide transport
L6426_RS23015	COG0811	peptide transport
L6426_RS23025	COG2771	luxR family
L6426_RS23030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L6426_RS23035	COG1349	DNA-binding transcription factor activity
L6426_RS23040	COG0745	RESPONSE REGULATOR receiver
L6426_RS23045	COG2205	protein histidine kinase activity
L6426_RS23055	COG4452	Inner membrane protein CreD
L6426_RS23060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L6426_RS23065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L6426_RS23070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L6426_RS23075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L6426_RS23080	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L6426_RS23085	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L6426_RS23090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L6426_RS23100	COG0356	it plays a direct role in the translocation of protons across the membrane
L6426_RS23110	COG1475	DNA binding
L6426_RS23115	COG1192	Involved in chromosome partitioning
L6426_RS23120	COG0357	Ribosomal RNA small subunit methyltransferase G
L6426_RS23125	COG0445	tRNA wobble uridine modification
L6426_RS23130	COG0716	FMN binding
L6426_RS23140	COG4615	Cyclic peptide transporter
L6426_RS23145	COG1120	ATPase activity
L6426_RS23150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6426_RS23160	COG3550	peptidyl-serine autophosphorylation
L6426_RS23185	COG0732	type I restriction modification DNA specificity domain
L6426_RS23200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L6426_RS23235	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L6426_RS23240	COG3041	Addiction module toxin RelE StbE family
L6426_RS23270	COG4251	negative regulation of phosphorylation
L6426_RS23285	COG0789	Transcriptional regulator
L6426_RS23295	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L6426_RS23315	COG0840	transmembrane signaling receptor activity
L6426_RS23350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L6426_RS23365	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6426_RS23370	COG3263	regulation of cellular component size
L6426_RS23400	COG0789	Transcriptional regulator
L6426_RS23490	COG1937	Protein conserved in bacteria
L6426_RS23495	COG1230	cation diffusion facilitator family transporter
L6426_RS23500	COG0640	Transcriptional regulator
L6426_RS23520	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6426_RS23530	COG0583	DNA-binding transcription factor activity
L6426_RS23540	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6426_RS23545	COG0625	glutathione transferase activity
L6426_RS23615	COG3385	transposase activity
L6426_RS23630	COG3041	Addiction module toxin RelE StbE family
L6426_RS23635	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L6426_RS23645	COG1028	Short-chain dehydrogenase reductase Sdr
L6426_RS23690	COG4974	Belongs to the 'phage' integrase family
L6426_RS23695	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L6426_RS23700	COG0706	membrane insertase activity
L6426_RS23705	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
L6426_RS23710	COG0594	ribonuclease P activity
L6426_RS23715	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L6426_RS23720	COG1126	abc transporter atp-binding protein