locus-tag	class	description
C1C92_RS00075	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1C92_RS00085	COG1684	flagellar biosynthetic protein fliR
C1C92_RS00140	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C1C92_RS00150	COG1677	Flagellar hook-basal body complex protein FliE
C1C92_RS00165	COG1393	Belongs to the ArsC family
C1C92_RS00170	COG0798	PFAM Bile acid sodium symporter
C1C92_RS00175	COG0640	Transcriptional regulator
C1C92_RS00185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1C92_RS00200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1C92_RS00205	COG0444	Belongs to the ABC transporter superfamily
C1C92_RS00210	COG4608	Belongs to the ABC transporter superfamily
C1C92_RS00220	COG2971	BadF BadG BcrA BcrD
C1C92_RS00230	COG0840	transmembrane signaling receptor activity
C1C92_RS00245	COG3724	N-succinylarginine dihydrolase activity
C1C92_RS00250	COG0616	signal peptide processing
C1C92_RS00255	COG1028	Short-chain dehydrogenase reductase Sdr
C1C92_RS00260	COG0583	DNA-binding transcription factor activity
C1C92_RS00270	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1C92_RS00280	COG0583	DNA-binding transcription factor activity
C1C92_RS00285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1C92_RS00290	COG1881	PFAM PEBP family protein
C1C92_RS00300	COG3408	Glycogen debranching enzyme
C1C92_RS00300	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C1C92_RS00305	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1C92_RS00310	COG0739	heme binding
C1C92_RS00315	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C1C92_RS00355	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1C92_RS00365	COG3091	SprT-like family
C1C92_RS00375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C1C92_RS00380	COG0189	ligase activity
C1C92_RS00390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1C92_RS00410	COG1115	amino acid carrier protein
C1C92_RS00415	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1C92_RS00430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C1C92_RS00440	COG1301	dicarboxylic acid transport
C1C92_RS00445	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C1C92_RS00450	COG2912	Transglutaminase-like superfamily
C1C92_RS00460	COG2890	protein-(glutamine-N5) methyltransferase activity
C1C92_RS00465	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C1C92_RS00470	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C1C92_RS00475	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C1C92_RS00480	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C1C92_RS00490	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1C92_RS00495	COG0193	aminoacyl-tRNA hydrolase activity
C1C92_RS00500	COG0012	GTP binding
C1C92_RS00545	COG0490	domain, Protein
C1C92_RS00545	COG0471	metal ion transport
C1C92_RS00570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1C92_RS00595	COG1012	belongs to the aldehyde dehydrogenase family
C1C92_RS00605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1C92_RS00620	COG0180	Tryptophanyl-tRNA synthetase
C1C92_RS00625	COG0546	phosphoglycolate phosphatase activity
C1C92_RS00630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C1C92_RS00635	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C1C92_RS00645	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1C92_RS00650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1C92_RS00680	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1C92_RS00685	COG0583	DNA-binding transcription factor activity
C1C92_RS00700	COG0583	DNA-binding transcription factor activity
C1C92_RS00710	COG0739	heme binding
C1C92_RS00720	COG1511	domain protein
C1C92_RS00720	COG3264	Mechanosensitive ion channel
C1C92_RS00725	COG0584	glycerophosphoryl diester phosphodiesterase
C1C92_RS00735	COG1053	succinate dehydrogenase
C1C92_RS00740	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1C92_RS00745	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C1C92_RS00750	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C1C92_RS00765	COG3214	Protein conserved in bacteria
C1C92_RS00770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1C92_RS00790	COG0300	oxidoreductase activity
C1C92_RS00810	COG4067	protein conserved in archaea
C1C92_RS00810	COG0189	ligase activity
C1C92_RS00815	COG0516	GMP reductase activity
C1C92_RS00825	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1C92_RS00830	COG2011	ABC-type metal ion transport system permease component
C1C92_RS00840	COG1464	Belongs to the NlpA lipoprotein family
C1C92_RS00855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1C92_RS00865	COG2199	diguanylate cyclase activity
C1C92_RS00875	COG2199	diguanylate cyclase activity
C1C92_RS00880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1C92_RS00895	COG1335	isochorismatase
C1C92_RS00900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1C92_RS00910	COG1702	phosphate starvation-inducible protein PhoH
C1C92_RS00915	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C1C92_RS00920	COG4535	Mg2 and Co2 transporter CorC
C1C92_RS00925	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C1C92_RS00930	COG2888	peptidyl-tyrosine sulfation
C1C92_RS00935	COG0495	leucyl-tRNA aminoacylation
C1C92_RS00950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1C92_RS00955	COG0799	negative regulation of ribosome biogenesis
C1C92_RS00960	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C1C92_RS00965	COG0768	penicillin binding
C1C92_RS00970	COG0772	Belongs to the SEDS family
C1C92_RS00975	COG2951	lytic endotransglycosylase activity
C1C92_RS00980	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C1C92_RS00985	COG1686	Belongs to the peptidase S11 family
C1C92_RS00990	COG2921	Belongs to the UPF0250 family
C1C92_RS00995	COG0321	lipoyl(octanoyl) transferase activity
C1C92_RS01000	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C1C92_RS01010	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1C92_RS01025	COG0789	Transcriptional regulator
C1C92_RS01030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C1C92_RS01040	COG1970	mechanosensitive ion channel activity
C1C92_RS01045	COG4974	Belongs to the 'phage' integrase family
C1C92_RS01055	COG0312	modulator of DNA gyrase
C1C92_RS01060	COG0312	modulator of DNA gyrase
C1C92_RS01075	COG0826	peptidase U32
C1C92_RS01080	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1C92_RS01095	COG1422	Protein of unknown function (DUF1090)
C1C92_RS01100	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C1C92_RS01105	COG2211	Major facilitator Superfamily
C1C92_RS01110	COG1185	polyribonucleotide nucleotidyltransferase activity
C1C92_RS01115	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1C92_RS01120	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C1C92_RS01125	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C1C92_RS01130	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C1C92_RS01135	COG0195	Participates in both transcription termination and antitermination
C1C92_RS01140	COG0779	Required for maturation of 30S ribosomal subunits
C1C92_RS01155	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1C92_RS01160	COG0149	triose-phosphate isomerase activity
C1C92_RS01165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1C92_RS01170	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1C92_RS01180	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C1C92_RS01185	COG1534	Rna-binding protein
C1C92_RS01200	COG1360	Flagellar Motor Protein
C1C92_RS01205	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1C92_RS01210	COG1722	exodeoxyribonuclease VII activity
C1C92_RS01215	COG0142	geranyltranstransferase activity
C1C92_RS01220	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1C92_RS01225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1C92_RS01230	COG0601	transmembrane transport
C1C92_RS01240	COG4172	Belongs to the ABC transporter superfamily
C1C92_RS01245	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C1C92_RS01250	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C1C92_RS01255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1C92_RS01260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C1C92_RS01275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1C92_RS01275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1C92_RS01280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1C92_RS01310	COG3550	peptidyl-serine autophosphorylation
C1C92_RS01340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1C92_RS01355	COG3381	protein complex oligomerization
C1C92_RS01370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1C92_RS01375	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C1C92_RS01380	COG0511	ligase activity, forming carbon-carbon bonds
C1C92_RS01385	COG0439	Biotin carboxylase
C1C92_RS01390	COG3924	membrane
C1C92_RS01395	COG4145	pantothenate transmembrane transporter activity
C1C92_RS01400	COG2190	(PTS) system
C1C92_RS01400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1C92_RS01400	COG1263	PTS System
C1C92_RS01405	COG0583	DNA-binding transcription factor activity
C1C92_RS01410	COG0604	alcohol dehydrogenase
C1C92_RS01415	COG2264	protein methyltransferase activity
C1C92_RS01420	COG0110	maltose O-acetyltransferase activity
C1C92_RS01430	COG0778	Nitroreductase
C1C92_RS01440	COG0616	signal peptide processing
C1C92_RS01460	COG3139	Protein of unknown function (DUF1315)
C1C92_RS01465	COG0252	asparaginase activity
C1C92_RS01470	COG0786	glutamate:sodium symporter activity
C1C92_RS01485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C1C92_RS01490	COG0384	phenazine biosynthesis protein PhzF
C1C92_RS01495	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1C92_RS01500	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1C92_RS01505	COG0175	sulfate reduction
C1C92_RS01510	COG2113	Glycine betaine
C1C92_RS01515	COG4176	ABC-type proline glycine betaine transport system permease component
C1C92_RS01520	COG4175	Glycine betaine
C1C92_RS01530	COG3610	response to peptide
C1C92_RS01535	COG2966	Psort location CytoplasmicMembrane, score
C1C92_RS01545	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1C92_RS01570	COG2313	pseudouridylate synthase activity
C1C92_RS01575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1C92_RS01580	COG2146	nitrite reductase [NAD(P)H] activity
C1C92_RS01580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1C92_RS01585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1C92_RS01585	COG2146	nitrite reductase [NAD(P)H] activity
C1C92_RS01590	COG1116	anion transmembrane transporter activity
C1C92_RS01595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1C92_RS01600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1C92_RS01600	COG1116	anion transmembrane transporter activity
C1C92_RS01610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1C92_RS01610	COG1648	precorrin-2 dehydrogenase activity
C1C92_RS01615	COG0243	molybdopterin cofactor binding
C1C92_RS01645	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1C92_RS01660	COG1073	alpha beta
C1C92_RS01665	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C1C92_RS01675	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1C92_RS01685	COG4608	Belongs to the ABC transporter superfamily
C1C92_RS01690	COG0444	Belongs to the ABC transporter superfamily
C1C92_RS01700	COG4239	(ABC) transporter, permease
C1C92_RS01705	COG4174	ABC transporter (Permease)
C1C92_RS01710	COG4206	TonB-dependent receptor
C1C92_RS01720	COG0811	peptide transport
C1C92_RS01725	COG0811	peptide transport
C1C92_RS01730	COG0848	biopolymer transport protein
C1C92_RS01780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1C92_RS01785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1C92_RS01790	COG0840	transmembrane signaling receptor activity
C1C92_RS01800	COG1278	Cold shock
C1C92_RS01840	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C1C92_RS01845	COG1162	GTPase activity
C1C92_RS01850	COG0688	phosphatidylethanolamine metabolic process
C1C92_RS01855	COG4628	conserved protein (DUF2132)
C1C92_RS01875	COG5001	Diguanylate cyclase
C1C92_RS01875	COG3300	MHYT domain
C1C92_RS01880	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C1C92_RS01905	COG1132	(ABC) transporter
C1C92_RS01915	COG2897	thiosulfate sulfurtransferase activity
C1C92_RS01920	COG2066	Belongs to the glutaminase family
C1C92_RS01925	COG3171	Protein conserved in bacteria
C1C92_RS01930	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C1C92_RS01935	COG2234	aminopeptidase activity
C1C92_RS01935	COG4935	Belongs to the peptidase S8 family
C1C92_RS01940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1C92_RS01945	COG2200	EAL domain
C1C92_RS01950	COG1090	epimerase
C1C92_RS01955	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C1C92_RS01960	COG4181	ATPase activity
C1C92_RS01965	COG2755	lipolytic protein G-D-S-L family
C1C92_RS01970	COG0835	chemotaxis
C1C92_RS01970	COG0784	Response regulator, receiver
C1C92_RS01980	COG0517	IMP dehydrogenase activity
C1C92_RS01980	COG0516	GMP reductase activity
C1C92_RS01985	COG0488	(ABC) transporter
C1C92_RS01995	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C1C92_RS02035	COG0789	Transcriptional regulator
C1C92_RS02045	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1C92_RS02055	COG0668	transmembrane transport
C1C92_RS02065	COG2731	YhcH YjgK YiaL family protein
C1C92_RS02075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1C92_RS02080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1C92_RS02085	COG3227	Zinc metalloprotease (Elastase)
C1C92_RS02090	COG0583	DNA-binding transcription factor activity
C1C92_RS02095	COG0477	Major facilitator Superfamily
C1C92_RS02115	COG0569	domain protein
C1C92_RS02115	COG2985	domain, Protein
C1C92_RS02120	COG1272	protein, Hemolysin III
C1C92_RS02125	COG0076	glutamate decarboxylase activity
C1C92_RS02130	COG2917	probably involved in intracellular septation
C1C92_RS02135	COG2350	Protein conserved in bacteria
C1C92_RS02145	COG1555	photosystem II stabilization
C1C92_RS02150	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C1C92_RS02155	COG3104	oligopeptide transport
C1C92_RS02160	COG0745	RESPONSE REGULATOR receiver
C1C92_RS02190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C92_RS02205	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C1C92_RS02210	COG1280	lysine exporter protein (LysE YggA)
C1C92_RS02235	COG0316	Belongs to the HesB IscA family
C1C92_RS02245	COG0038	chloride channel
C1C92_RS02250	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C1C92_RS02265	COG0671	phosphoesterase, PA-phosphatase related
C1C92_RS02275	COG0583	DNA-binding transcription factor activity
C1C92_RS02280	COG2076	Multidrug Resistance protein
C1C92_RS02290	COG0346	lactoylglutathione lyase activity
C1C92_RS02295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1C92_RS02300	COG1643	Atp-dependent helicase
C1C92_RS02310	COG1489	DNA binding
C1C92_RS02315	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1C92_RS02320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1C92_RS02330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C1C92_RS02335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C1C92_RS02340	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C1C92_RS02350	COG0842	Transport permease protein
C1C92_RS02355	COG1131	(ABC) transporter
C1C92_RS02370	COG0163	prenyltransferase activity
C1C92_RS02375	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1C92_RS02380	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C1C92_RS02395	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C1C92_RS02410	COG1136	(ABC) transporter
C1C92_RS02450	COG2801	Transposase and inactivated derivatives
C1C92_RS02455	COG0529	Catalyzes the synthesis of activated sulfate
C1C92_RS02460	COG0471	metal ion transport
C1C92_RS02460	COG3273	potassium ion transport
C1C92_RS02465	COG2895	sulfate adenylyltransferase (ATP) activity
C1C92_RS02470	COG0175	sulfate reduction
C1C92_RS02475	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1C92_RS02475	COG1648	precorrin-2 dehydrogenase activity
C1C92_RS02480	COG0330	HflC and HflK could
C1C92_RS02485	COG1585	Membrane protein implicated in regulation of membrane protease activity
C1C92_RS02495	COG0673	inositol 2-dehydrogenase activity
C1C92_RS02505	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1C92_RS02510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1C92_RS02515	COG3036	rescue of stalled ribosome
C1C92_RS02530	COG0138	bifunctional purine biosynthesis protein purh
C1C92_RS02565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1C92_RS02570	COG0358	DNA primase activity
C1C92_RS02575	COG1610	YqeY-like protein
C1C92_RS02580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1C92_RS02585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1C92_RS02595	COG1388	LysM domain
C1C92_RS02595	COG4942	peptidase
C1C92_RS02600	COG1238	metal cluster binding
C1C92_RS02605	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1C92_RS02610	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C1C92_RS02615	COG0585	pseudouridine synthase activity
C1C92_RS02625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1C92_RS02630	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C1C92_RS02635	COG0148	phosphopyruvate hydratase activity
C1C92_RS02640	COG0504	CTP synthase activity
C1C92_RS02645	COG3956	TIGRFAM MazG family protein
C1C92_RS02650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1C92_RS02655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1C92_RS02665	COG4807	Protein conserved in bacteria
C1C92_RS02670	COG3023	N-Acetylmuramoyl-L-alanine amidase
C1C92_RS02675	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C1C92_RS02680	COG1381	Involved in DNA repair and RecF pathway recombination
C1C92_RS02690	COG0571	ribonuclease III activity
C1C92_RS02695	COG0681	Belongs to the peptidase S26 family
C1C92_RS02700	COG0481	GTPase activity
C1C92_RS02715	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C1C92_RS02720	COG1595	DNA-templated transcription, initiation
C1C92_RS02725	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C1C92_RS02735	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C1C92_RS02745	COG0583	DNA-binding transcription factor activity
C1C92_RS02780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1C92_RS02790	COG0126	phosphoglycerate kinase activity
C1C92_RS02795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1C92_RS02800	COG1940	carbohydrate kinase activity
C1C92_RS02805	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C1C92_RS02810	COG2816	NAD+ diphosphatase activity
C1C92_RS02815	COG4991	sh3 domain protein
C1C92_RS02820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1C92_RS02835	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C1C92_RS02840	COG1028	Short-chain dehydrogenase reductase Sdr
C1C92_RS02855	COG1505	serine-type exopeptidase activity
C1C92_RS02860	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C1C92_RS02865	COG0765	amino acid transport
C1C92_RS02870	COG0765	amino acid transport
C1C92_RS02875	COG1126	abc transporter atp-binding protein
C1C92_RS02880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C92_RS02885	COG3174	membrane
C1C92_RS02890	COG0110	maltose O-acetyltransferase activity
C1C92_RS02930	COG0583	DNA-binding transcription factor activity
C1C92_RS02935	COG0165	Argininosuccinate lyase
C1C92_RS02940	COG0137	argininosuccinate synthase activity
C1C92_RS02950	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1C92_RS02955	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1C92_RS02965	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C1C92_RS02975	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1C92_RS03010	COG0583	DNA-binding transcription factor activity
C1C92_RS03015	COG1380	Effector of murein hydrolase LrgA
C1C92_RS03020	COG1346	cytolysis
C1C92_RS03025	COG0460	homoserine dehydrogenase
C1C92_RS03025	COG0527	aspartate kinase activity
C1C92_RS03030	COG0626	cystathionine gamma-synthase activity
C1C92_RS03045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1C92_RS03055	COG1218	3'(2'),5'-bisphosphate nucleotidase
C1C92_RS03060	COG0494	nUDIX hydrolase
C1C92_RS03065	COG1011	Hydrolase
C1C92_RS03080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1C92_RS03095	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C1C92_RS03105	COG3156	type II secretion system protein K
C1C92_RS03110	COG4795	General secretion pathway protein
C1C92_RS03115	COG2165	general secretion pathway protein
C1C92_RS03125	COG2165	general secretion pathway protein
C1C92_RS03130	COG1459	type II secretion system
C1C92_RS03135	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1C92_RS03145	COG3031	protein transport across the cell outer membrane
C1C92_RS03155	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C1C92_RS03160	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C1C92_RS03175	COG0456	acetyltransferase
C1C92_RS03180	COG3133	Outer membrane lipoprotein
C1C92_RS03185	COG3025	triphosphatase activity
C1C92_RS03190	COG1392	Phosphate transport regulator
C1C92_RS03195	COG0306	phosphate transporter
C1C92_RS03200	COG0617	tRNA 3'-terminal CCA addition
C1C92_RS03205	COG3267	Type II secretory pathway component ExeA
C1C92_RS03205	COG3409	Peptidoglycan-binding domain 1 protein
C1C92_RS03215	COG1194	a g-specific adenine glycosylase
C1C92_RS03220	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C1C92_RS03235	COG3240	lipase activity
C1C92_RS03245	COG3009	Protein conserved in bacteria
C1C92_RS03250	COG3008	intermembrane lipid transfer
C1C92_RS03250	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1C92_RS03255	COG2995	paraquat-inducible protein a
C1C92_RS03265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1C92_RS03270	COG3706	GGDEF domain
C1C92_RS03270	COG4251	negative regulation of phosphorylation
C1C92_RS03270	COG5001	Diguanylate cyclase
C1C92_RS03270	COG2203	Gaf domain
C1C92_RS03275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1C92_RS03280	COG2813	Specifically methylates the guanine in position
C1C92_RS03285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1C92_RS03290	COG0297	glycogen (starch) synthase activity
C1C92_RS03330	COG1757	Na H antiporter
C1C92_RS03335	COG0583	DNA-binding transcription factor activity
C1C92_RS03340	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C1C92_RS03345	COG3842	ATPase activity
C1C92_RS03350	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1C92_RS03355	COG1177	transmembrane transport
C1C92_RS03360	COG1012	belongs to the aldehyde dehydrogenase family
C1C92_RS03365	COG0109	protoheme IX farnesyltransferase activity
C1C92_RS03395	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C1C92_RS03405	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C1C92_RS03405	COG1565	acr, cog1565
C1C92_RS03410	COG1444	tRNA N-acetyltransferase activity
C1C92_RS03430	COG1803	Methylglyoxal synthase
C1C92_RS03445	COG0252	asparaginase activity
C1C92_RS03465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1C92_RS03465	COG1263	PTS System
C1C92_RS03470	COG0366	Alpha amylase catalytic
C1C92_RS03475	COG0110	maltose O-acetyltransferase activity
C1C92_RS03480	COG1522	sequence-specific DNA binding
C1C92_RS03510	COG3068	Protein conserved in bacteria
C1C92_RS03520	COG0739	heme binding
C1C92_RS03540	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C1C92_RS03545	COG1121	(ABC) transporter
C1C92_RS03550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1C92_RS03555	COG0583	DNA-binding transcription factor activity
C1C92_RS03565	COG1573	uracil-dna glycosylase
C1C92_RS03570	COG2962	Rard protein
C1C92_RS03575	COG2827	Endonuclease containing a URI domain
C1C92_RS03590	COG1842	Phage shock protein A
C1C92_RS03595	COG0204	Acyl-transferase
C1C92_RS03615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1C92_RS03625	COG0484	heat shock protein binding
C1C92_RS03660	COG2801	Transposase and inactivated derivatives
C1C92_RS03675	COG1289	transmembrane transporter activity
C1C92_RS03680	COG1566	PFAM secretion protein HlyD family protein
C1C92_RS03695	COG1051	belongs to the nudix hydrolase family
C1C92_RS03700	COG3150	esterase
C1C92_RS03710	COG3151	Protein conserved in bacteria
C1C92_RS03715	COG0494	nUDIX hydrolase
C1C92_RS03720	COG1538	Outer membrane efflux protein
C1C92_RS03725	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C1C92_RS03725	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C1C92_RS03730	COG1560	Kdo2-lipid A biosynthetic process
C1C92_RS03745	COG2771	luxR family
C1C92_RS03760	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C1C92_RS03770	COG2213	PTS system mannitol-specific
C1C92_RS03770	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1C92_RS03775	COG0246	Mannitol dehydrogenase
C1C92_RS03780	COG3722	fumarate hydratase activity
C1C92_RS03785	COG3263	regulation of cellular component size
C1C92_RS03805	COG1671	Belongs to the UPF0178 family
C1C92_RS03820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1C92_RS03825	COG0513	Belongs to the DEAD box helicase family
C1C92_RS03845	COG1575	Belongs to the MenA family. Type 1 subfamily
C1C92_RS03850	COG1169	isochorismate synthase
C1C92_RS03855	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C1C92_RS03860	COG0596	Alpha beta hydrolase
C1C92_RS03865	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C1C92_RS03875	COG0318	PFAM AMP-dependent synthetase and ligase
C1C92_RS03880	COG3291	Pkd domain containing protein
C1C92_RS03885	COG2949	membrane
C1C92_RS03890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C1C92_RS03900	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C1C92_RS03930	COG2873	o-acetylhomoserine
C1C92_RS03940	COG1979	alcohol dehydrogenase
C1C92_RS03955	COG4221	oxidoreductase activity
C1C92_RS03975	COG1285	pathogenesis
C1C92_RS03990	COG1368	sulfuric ester hydrolase activity
C1C92_RS03995	COG1522	sequence-specific DNA binding
C1C92_RS04005	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C1C92_RS04015	COG1058	Belongs to the CinA family
C1C92_RS04015	COG1546	Belongs to the CinA family
C1C92_RS04020	COG1988	membrane-bound metal-dependent
C1C92_RS04035	COG0561	phosphatase activity
C1C92_RS04040	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C1C92_RS04050	COG1011	Hydrolase
C1C92_RS04065	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C1C92_RS04070	COG0019	diaminopimelate decarboxylase activity
C1C92_RS04080	COG1965	Belongs to the frataxin family
C1C92_RS04085	COG0400	carboxylic ester hydrolase activity
C1C92_RS04090	COG3072	Adenylate cyclase
C1C92_RS04095	COG0181	hydroxymethylbilane synthase activity
C1C92_RS04100	COG1587	Uroporphyrinogen-III synthase
C1C92_RS04105	COG2959	enzyme of heme biosynthesis
C1C92_RS04110	COG3071	HemY protein
C1C92_RS04115	COG0312	modulator of DNA gyrase
C1C92_RS04120	COG3028	Belongs to the UPF0307 family
C1C92_RS04130	COG2926	Belongs to the UPF0265 family
C1C92_RS04160	COG1396	sequence-specific DNA binding
C1C92_RS04165	COG3135	benzoate transporter
C1C92_RS04190	COG0840	transmembrane signaling receptor activity
C1C92_RS04195	COG3047	cAMP biosynthetic process
C1C92_RS04200	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1C92_RS04205	COG2197	response regulator
C1C92_RS04250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1C92_RS04290	COG1396	sequence-specific DNA binding
C1C92_RS04315	COG1278	Cold shock
C1C92_RS04345	COG3706	GGDEF domain
C1C92_RS04350	COG0347	Belongs to the P(II) protein family
C1C92_RS04355	COG0004	ammonium transporteR
C1C92_RS04370	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1C92_RS04375	COG1074	ATP-dependent DNA helicase activity
C1C92_RS04380	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C1C92_RS04385	COG2259	Doxx family
C1C92_RS04390	COG1741	Belongs to the pirin family
C1C92_RS04400	COG0583	DNA-binding transcription factor activity
C1C92_RS04425	COG1175	transmembrane transport
C1C92_RS04435	COG3842	ATPase activity
C1C92_RS04465	COG0456	acetyltransferase
C1C92_RS04470	COG0753	catalase activity
C1C92_RS04490	COG0494	nUDIX hydrolase
C1C92_RS04495	COG0628	permease
C1C92_RS04505	COG2957	Belongs to the agmatine deiminase family
C1C92_RS04520	COG2957	Belongs to the agmatine deiminase family
C1C92_RS04525	COG0583	DNA-binding transcription factor activity
C1C92_RS04540	COG1461	Dihydroxyacetone kinase
C1C92_RS04545	COG2376	Dihydroxyacetone kinase
C1C92_RS04550	COG2252	PERMEase
C1C92_RS04555	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C1C92_RS04585	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1C92_RS04590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1C92_RS04595	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1C92_RS04600	COG0049	tRNA binding
C1C92_RS04605	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C1C92_RS04610	COG2168	tRNA wobble position uridine thiolation
C1C92_RS04620	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C1C92_RS04625	COG0251	oxidation-reduction process
C1C92_RS04630	COG2964	Protein conserved in bacteria
C1C92_RS04635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1C92_RS04640	COG0085	RNA polymerase activity
C1C92_RS04645	COG0222	ribosome binding
C1C92_RS04650	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1C92_RS04655	COG0081	regulation of translation
C1C92_RS04660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C1C92_RS04665	COG0250	Participates in transcription elongation, termination and antitermination
C1C92_RS04680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1C92_RS04705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C1C92_RS04710	COG0569	domain protein
C1C92_RS04715	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1C92_RS04720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1C92_RS04725	COG3005	denitrification pathway
C1C92_RS04780	COG2204	response regulator
C1C92_RS04790	COG2205	protein histidine kinase activity
C1C92_RS04810	COG0516	GMP reductase activity
C1C92_RS04810	COG0517	IMP dehydrogenase activity
C1C92_RS04820	COG1522	sequence-specific DNA binding
C1C92_RS04825	COG2502	aspartate--ammonia ligase
C1C92_RS04840	COG0583	DNA-binding transcription factor activity
C1C92_RS04850	COG0542	response to heat
C1C92_RS04860	COG0564	pseudouridine synthase activity
C1C92_RS04865	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1C92_RS04870	COG3681	Belongs to the UPF0597 family
C1C92_RS04875	COG2964	Protein conserved in bacteria
C1C92_RS04880	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C1C92_RS04885	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C1C92_RS04890	COG1979	alcohol dehydrogenase
C1C92_RS04895	COG2207	Transcriptional regulator
C1C92_RS04920	COG0583	DNA-binding transcription factor activity
C1C92_RS04940	COG0540	Belongs to the ATCase OTCase family
C1C92_RS04945	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
C1C92_RS04950	COG1438	arginine binding
C1C92_RS04960	COG1288	antiporter activity
C1C92_RS04965	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C1C92_RS05005	COG3250	beta-galactosidase activity
C1C92_RS05010	COG1609	Transcriptional regulator
C1C92_RS05015	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1C92_RS05025	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C1C92_RS05030	COG2017	converts alpha-aldose to the beta-anomer
C1C92_RS05035	COG0667	Aldo Keto reductase
C1C92_RS05040	COG1968	undecaprenyl-diphosphatase activity
C1C92_RS05045	COG3806	Anti-sigma factor
C1C92_RS05050	COG1595	DNA-templated transcription, initiation
C1C92_RS05070	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C1C92_RS05075	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C1C92_RS05080	COG0477	Major facilitator Superfamily
C1C92_RS05095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C92_RS05100	COG1131	(ABC) transporter
C1C92_RS05105	COG0842	Transport permease protein
C1C92_RS05110	COG0842	Transport permease protein
C1C92_RS05115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1C92_RS05125	COG2116	formate transmembrane transporter activity
C1C92_RS05130	COG1648	precorrin-2 dehydrogenase activity
C1C92_RS05130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1C92_RS05135	COG2239	Acts as a magnesium transporter
C1C92_RS05140	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1C92_RS05145	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C1C92_RS05155	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C1C92_RS05165	COG0514	ATP-dependent DNA helicase (RecQ)
C1C92_RS05170	COG0514	ATP-dependent DNA helicase (RecQ)
C1C92_RS05175	COG2050	protein possibly involved in aromatic compounds catabolism
C1C92_RS05190	COG2258	MOSC domain
C1C92_RS05195	COG1177	transmembrane transport
C1C92_RS05200	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1C92_RS05205	COG3842	ATPase activity
C1C92_RS05225	COG0174	glutamine synthetase
C1C92_RS05245	COG3045	CreA protein
C1C92_RS05250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1C92_RS05255	COG0443	Heat shock 70 kDa protein
C1C92_RS05270	COG0366	Alpha amylase catalytic
C1C92_RS05280	COG4310	Domain of unknown function (DUF2172)
C1C92_RS05315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1C92_RS05320	COG0745	RESPONSE REGULATOR receiver
C1C92_RS05325	COG2205	protein histidine kinase activity
C1C92_RS05335	COG0281	malic enzyme
C1C92_RS05340	COG0702	epimerase
C1C92_RS05345	COG0254	rRNA binding
C1C92_RS05350	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C1C92_RS05355	COG1309	transcriptional regulator
C1C92_RS05375	COG0129	dihydroxy-acid dehydratase activity
C1C92_RS05385	COG3978	acetolactate synthase activity
C1C92_RS05400	COG0606	chelatase, subunit chli
C1C92_RS05405	COG0204	Acyl-transferase
C1C92_RS05410	COG0204	Acyl-transferase
C1C92_RS05415	COG1683	Conserved Protein
C1C92_RS05425	COG1335	isochorismatase
C1C92_RS05435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1C92_RS05440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C1C92_RS05450	COG3084	Protein conserved in bacteria
C1C92_RS05455	COG5001	Diguanylate cyclase
C1C92_RS05455	COG2203	Gaf domain
C1C92_RS05455	COG3706	GGDEF domain
C1C92_RS05455	COG4251	negative regulation of phosphorylation
C1C92_RS05470	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1C92_RS05475	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C1C92_RS05480	COG1561	YicC-like family, N-terminal region
C1C92_RS05490	COG1519	Transferase
C1C92_RS05495	COG0859	PFAM glycosyl transferase family 9
C1C92_RS05500	COG0463	Glycosyl transferase, family 2
C1C92_RS05505	COG0859	PFAM glycosyl transferase family 9
C1C92_RS05510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C1C92_RS05515	COG2990	Protein conserved in bacteria
C1C92_RS05520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1C92_RS05530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1C92_RS05535	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1C92_RS05540	COG2003	Belongs to the UPF0758 family
C1C92_RS05545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1C92_RS05550	COG0756	dUTP diphosphatase activity
C1C92_RS05555	COG1309	transcriptional regulator
C1C92_RS05575	COG0668	transmembrane transport
C1C92_RS05585	COG0166	Belongs to the GPI family
C1C92_RS05590	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1C92_RS05595	COG0583	DNA-binding transcription factor activity
C1C92_RS05605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1C92_RS05605	COG1042	CoA-binding domain protein
C1C92_RS05605	COG0045	succinate-CoA ligase (ADP-forming) activity
C1C92_RS05635	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C1C92_RS05640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1C92_RS05645	COG1739	Uncharacterized protein family UPF0029
C1C92_RS05650	COG0006	proline dipeptidase activity
C1C92_RS05655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1C92_RS05660	COG1024	Enoyl-CoA hydratase
C1C92_RS05660	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1C92_RS05665	COG0183	Belongs to the thiolase family
C1C92_RS05695	COG0425	Belongs to the sulfur carrier protein TusA family
C1C92_RS05700	COG0251	oxidation-reduction process
C1C92_RS05705	COG2885	chlorophyll binding
C1C92_RS05715	COG1335	isochorismatase
C1C92_RS05720	COG2818	Glycosylase
C1C92_RS05725	COG0752	glycyl-tRNA synthetase alpha subunit
C1C92_RS05730	COG0751	glycine-tRNA ligase activity
C1C92_RS05740	COG3604	Transcriptional regulator
C1C92_RS05745	COG0426	domain, Protein
C1C92_RS05745	COG1773	rubredoxin
C1C92_RS05750	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1C92_RS05760	COG0348	domain, Protein
C1C92_RS05770	COG3033	Beta-eliminating lyase
C1C92_RS05775	COG0814	amino acid
C1C92_RS05780	COG0814	amino acid
C1C92_RS05800	COG2203	Gaf domain
C1C92_RS05800	COG3706	GGDEF domain
C1C92_RS05800	COG4251	negative regulation of phosphorylation
C1C92_RS05800	COG5001	Diguanylate cyclase
C1C92_RS05810	COG1609	Transcriptional regulator
C1C92_RS05850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1C92_RS05865	COG2960	long-chain fatty acid transporting porin activity
C1C92_RS05875	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C1C92_RS05890	COG3118	belongs to the thioredoxin family
C1C92_RS05895	COG0513	Belongs to the DEAD box helicase family
C1C92_RS05900	COG0248	Ppx GppA phosphatase
C1C92_RS05910	COG0742	ribosomal rna small subunit methyltransferase
C1C92_RS05930	COG0084	hydrolase, TatD family'
C1C92_RS05935	COG0805	protein transport
C1C92_RS05940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1C92_RS05945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1C92_RS05950	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C1C92_RS05955	COG3165	ubiquinone biosynthetic process from chorismate
C1C92_RS05965	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1C92_RS05970	COG0402	S-adenosylhomocysteine deaminase activity
C1C92_RS06005	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C1C92_RS06010	COG0848	biopolymer transport protein
C1C92_RS06015	COG0811	peptide transport
C1C92_RS06020	COG0811	peptide transport
C1C92_RS06030	COG2771	luxR family
C1C92_RS06035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1C92_RS06040	COG1349	DNA-binding transcription factor activity
C1C92_RS06045	COG0745	RESPONSE REGULATOR receiver
C1C92_RS06050	COG2205	protein histidine kinase activity
C1C92_RS06060	COG4452	Inner membrane protein CreD
C1C92_RS06065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1C92_RS06070	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1C92_RS06075	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1C92_RS06080	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1C92_RS06085	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1C92_RS06090	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1C92_RS06095	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1C92_RS06105	COG0356	it plays a direct role in the translocation of protons across the membrane
C1C92_RS06115	COG1475	DNA binding
C1C92_RS06120	COG1192	Involved in chromosome partitioning
C1C92_RS06125	COG0357	Ribosomal RNA small subunit methyltransferase G
C1C92_RS06130	COG0445	tRNA wobble uridine modification
C1C92_RS06135	COG0716	FMN binding
C1C92_RS06145	COG4615	Cyclic peptide transporter
C1C92_RS06150	COG1120	ATPase activity
C1C92_RS06155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1C92_RS06165	COG3550	peptidyl-serine autophosphorylation
C1C92_RS06230	COG1695	Transcriptional regulator
C1C92_RS06265	COG3173	Aminoglycoside phosphotransferase
C1C92_RS06335	COG0732	type I restriction modification DNA specificity domain
C1C92_RS06385	COG4974	Belongs to the 'phage' integrase family
C1C92_RS06390	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C1C92_RS06395	COG0706	membrane insertase activity
C1C92_RS06400	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C1C92_RS06405	COG0594	ribonuclease P activity
C1C92_RS06410	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C1C92_RS06415	COG1126	abc transporter atp-binding protein
C1C92_RS06430	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1C92_RS06435	COG0592	DNA-directed DNA polymerase activity
C1C92_RS06445	COG0187	DNA topoisomerase II activity
C1C92_RS06450	COG2207	Transcriptional regulator
C1C92_RS06455	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C1C92_RS06460	COG0071	Belongs to the small heat shock protein (HSP20) family
C1C92_RS06465	COG0071	Belongs to the small heat shock protein (HSP20) family
C1C92_RS06470	COG3977	Valine--pyruvate aminotransferase
C1C92_RS06485	COG2814	Major facilitator Superfamily
C1C92_RS06490	COG0745	RESPONSE REGULATOR receiver
C1C92_RS06495	COG2205	protein histidine kinase activity
C1C92_RS06525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1C92_RS06530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C92_RS06530	COG4191	Histidine kinase
C1C92_RS06535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1C92_RS06540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C92_RS06545	COG1309	transcriptional regulator
C1C92_RS06575	COG0561	phosphatase activity
C1C92_RS06580	COG2267	carboxylic ester hydrolase activity
C1C92_RS06585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1C92_RS06590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1C92_RS06595	COG1758	RNA polymerase activity
C1C92_RS06610	COG0859	PFAM glycosyl transferase family 9
C1C92_RS06615	COG3642	lipopolysaccharide core region biosynthetic process
C1C92_RS06655	COG0589	response to stress
C1C92_RS06665	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1C92_RS06670	COG3706	GGDEF domain
C1C92_RS06675	COG1528	Iron-storage protein
C1C92_RS06680	COG2081	HI0933 family
C1C92_RS06685	COG2223	nitrite transmembrane transporter activity
C1C92_RS06690	COG1280	lysine exporter protein (LysE YggA)
C1C92_RS06700	COG3188	usher protein
C1C92_RS06720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C92_RS06720	COG2205	protein histidine kinase activity
C1C92_RS06730	COG3275	phosphorelay sensor kinase activity
C1C92_RS06735	COG3279	Response regulator of the LytR AlgR family
C1C92_RS06740	COG2223	nitrite transmembrane transporter activity
C1C92_RS06745	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C1C92_RS06750	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C1C92_RS06795	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C1C92_RS06800	COG2166	iron-sulfur cluster assembly
C1C92_RS06805	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1C92_RS06825	COG1063	alcohol dehydrogenase
C1C92_RS06830	COG0156	8-amino-7-oxononanoate synthase activity
C1C92_RS06840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1C92_RS06885	COG1609	Transcriptional regulator
C1C92_RS06905	COG1580	Controls the rotational direction of flagella during chemotaxis
C1C92_RS06910	COG3161	chorismate lyase activity
C1C92_RS06915	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C1C92_RS06920	COG2937	Belongs to the GPAT DAPAT family
C1C92_RS06925	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1C92_RS06940	COG0534	Mate efflux family protein
C1C92_RS06945	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C1C92_RS06950	COG2205	protein histidine kinase activity
C1C92_RS06955	COG0745	RESPONSE REGULATOR receiver
C1C92_RS06965	COG1045	serine acetyltransferase
C1C92_RS06975	COG3074	FtsZ-dependent cytokinesis
C1C92_RS06980	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C1C92_RS06985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1C92_RS06985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1C92_RS06990	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C1C92_RS07030	COG1609	Transcriptional regulator
C1C92_RS07035	COG3250	beta-galactosidase activity
C1C92_RS07040	COG2731	YhcH YjgK YiaL family protein
C1C92_RS07045	COG0531	amino acid
C1C92_RS07050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1C92_RS07055	COG0531	amino acid
C1C92_RS07060	COG0385	Bile acid
C1C92_RS07065	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C1C92_RS07090	COG0583	DNA-binding transcription factor activity
C1C92_RS07095	COG1079	Belongs to the binding-protein-dependent transport system permease family
C1C92_RS07100	COG4603	Belongs to the binding-protein-dependent transport system permease family
C1C92_RS07105	COG3845	ABC transporter
C1C92_RS07110	COG1744	ABC transporter substrate-binding protein PnrA-like
C1C92_RS07115	COG0210	DNA helicase
C1C92_RS07130	COG1943	Transposase
C1C92_RS07135	COG0583	DNA-binding transcription factor activity
C1C92_RS07170	COG0583	DNA-binding transcription factor activity
C1C92_RS07185	COG1280	lysine exporter protein (LysE YggA)
C1C92_RS07195	COG2962	Rard protein
C1C92_RS07200	COG1012	belongs to the aldehyde dehydrogenase family
C1C92_RS07205	COG1396	sequence-specific DNA binding
C1C92_RS07210	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1C92_RS07220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1C92_RS07220	COG0519	Catalyzes the synthesis of GMP from XMP
C1C92_RS07230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1C92_RS07250	COG1322	Protein conserved in bacteria
C1C92_RS07255	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1C92_RS07260	COG0569	domain protein
C1C92_RS07265	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1C92_RS07265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1C92_RS07270	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1C92_RS07275	COG0242	peptide deformylase activity
C1C92_RS07285	COG0758	DNA mediated transformation
C1C92_RS07290	COG2922	Belongs to the Smg family
C1C92_RS07295	COG0551	DNA topoisomerase type I activity
C1C92_RS07300	COG0009	L-threonylcarbamoyladenylate synthase
C1C92_RS07305	COG0408	coproporphyrinogen oxidase activity
C1C92_RS07310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1C92_RS07320	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C1C92_RS07330	COG3078	GTPase activator activity
C1C92_RS07340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1C92_RS07345	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1C92_RS07355	COG3852	Histidine kinase
C1C92_RS07365	COG0174	glutamine synthetase
C1C92_RS07370	COG1217	gtp-binding protein TYPA
C1C92_RS07375	COG1295	ribonuclease BN
C1C92_RS07380	COG1490	D-aminoacyl-tRNA deacylase activity
C1C92_RS07390	COG0456	acetyltransferase
C1C92_RS07400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1C92_RS07405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1C92_RS07410	COG2610	gluconate transmembrane transporter activity
C1C92_RS07415	COG3265	gluconokinase activity
C1C92_RS07420	COG0129	dihydroxy-acid dehydratase activity
C1C92_RS07425	COG0800	Aldolase
C1C92_RS07440	COG1609	Transcriptional regulator
C1C92_RS07450	COG4942	peptidase
C1C92_RS07455	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C1C92_RS07460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1C92_RS07465	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C1C92_RS07470	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1C92_RS07475	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C1C92_RS07475	COG0316	Belongs to the HesB IscA family
C1C92_RS07480	COG1040	competence protein
C1C92_RS07485	COG0596	Alpha beta hydrolase
C1C92_RS07500	COG2183	response to ionizing radiation
C1C92_RS07505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1C92_RS07515	COG2205	protein histidine kinase activity
C1C92_RS07525	COG0051	transcription antitermination factor activity, RNA binding
C1C92_RS07530	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C1C92_RS07535	COG0088	Forms part of the polypeptide exit tunnel
C1C92_RS07540	COG0089	rRNA binding
C1C92_RS07545	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C1C92_RS07550	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1C92_RS07555	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C1C92_RS07560	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C1C92_RS07565	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C1C92_RS07570	COG0255	Belongs to the universal ribosomal protein uL29 family
C1C92_RS07575	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C1C92_RS07580	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1C92_RS07585	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C1C92_RS07590	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C1C92_RS07595	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1C92_RS07600	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C1C92_RS07605	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C1C92_RS07610	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C1C92_RS07615	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1C92_RS07620	COG1841	ribosomal large subunit assembly
C1C92_RS07625	COG0200	Binds to the 23S rRNA
C1C92_RS07630	COG0201	protein transport
C1C92_RS07635	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1C92_RS07640	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1C92_RS07645	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1C92_RS07650	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C1C92_RS07655	COG0202	RNA polymerase activity
C1C92_RS07660	COG0203	ribosomal protein L17
C1C92_RS07715	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1C92_RS07720	COG0583	DNA-binding transcription factor activity
C1C92_RS07725	COG4221	oxidoreductase activity
C1C92_RS07740	COG1770	oligopeptidase
C1C92_RS07745	COG2358	TRAP transporter, solute receptor (TAXI family
C1C92_RS07760	COG3714	YhhN family
C1C92_RS07775	COG0583	DNA-binding transcription factor activity
C1C92_RS07785	COG1301	dicarboxylic acid transport
C1C92_RS07795	COG2095	MarC family integral membrane protein
C1C92_RS07805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1C92_RS07815	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C1C92_RS07820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1C92_RS07845	COG0742	ribosomal rna small subunit methyltransferase
C1C92_RS07850	COG0552	protein localization to endoplasmic reticulum
C1C92_RS07855	COG2884	Cell division ATP-binding protein ftsE
C1C92_RS07860	COG2177	Part of the ABC transporter FtsEX involved in
C1C92_RS07870	COG0288	reversible hydration of carbon dioxide
C1C92_RS07875	COG2188	Transcriptional regulator
C1C92_RS07880	COG1228	amidohydrolase
C1C92_RS07885	COG0010	Belongs to the arginase family
C1C92_RS07890	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C1C92_RS07895	COG2986	histidine ammonia-lyase
C1C92_RS07900	COG0387	Pfam Sodium calcium exchanger
C1C92_RS07905	COG2200	EAL domain
C1C92_RS07955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1C92_RS07960	COG1459	type II secretion system
C1C92_RS08005	COG1077	Cell shape determining protein MreB Mrl
C1C92_RS08010	COG1792	Involved in formation and maintenance of cell shape
C1C92_RS08015	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C1C92_RS08020	COG0424	maF-like protein
C1C92_RS08025	COG1530	ribonuclease E activity
C1C92_RS08035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1C92_RS08055	COG0477	Major facilitator Superfamily
C1C92_RS08065	COG2321	neutral zinc metallopeptidase
C1C92_RS08100	COG0189	ligase activity
C1C92_RS08105	COG0642	Histidine kinase
C1C92_RS08110	COG0745	RESPONSE REGULATOR receiver
C1C92_RS08125	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C1C92_RS08130	COG0352	thiamine-phosphate diphosphorylase activity
C1C92_RS08135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1C92_RS08145	COG2022	thiamine diphosphate biosynthetic process
C1C92_RS08170	COG0110	maltose O-acetyltransferase activity
C1C92_RS08185	COG3932	Exopolysaccharide synthesis, ExoD
C1C92_RS08200	COG1733	regulation of RNA biosynthetic process
C1C92_RS08225	COG2226	methyltransferase
C1C92_RS08235	COG1494	fructose-1,6-bisphosphatase
C1C92_RS08245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C1C92_RS08250	COG5007	Belongs to the BolA IbaG family
C1C92_RS08260	COG2854	intermembrane phospholipid transfer
C1C92_RS08265	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1C92_RS08270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1C92_RS08275	COG1127	ABC transporter
C1C92_RS08280	COG0517	IMP dehydrogenase activity
C1C92_RS08280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C1C92_RS08285	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C1C92_RS08295	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C1C92_RS08300	COG1137	ATPase activity
C1C92_RS08305	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C1C92_RS08315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1C92_RS08320	COG1660	Displays ATPase and GTPase activities
C1C92_RS08325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1C92_RS08345	COG3964	amidohydrolase
C1C92_RS08375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1C92_RS08380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1C92_RS08390	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C1C92_RS08395	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C1C92_RS08400	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C1C92_RS08405	COG0723	plastoquinol--plastocyanin reductase activity
C1C92_RS08410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C1C92_RS08415	COG2857	Cytochrome c1
C1C92_RS08420	COG0625	glutathione transferase activity
C1C92_RS08425	COG2969	positive regulation of protein catabolic process
C1C92_RS08430	COG2823	Periplasmic or secreted lipoprotein
C1C92_RS08435	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1C92_RS08440	COG0792	nuclease activity
C1C92_RS08445	COG3107	peptidoglycan biosynthetic process
C1C92_RS08450	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C1C92_RS08460	COG2001	Belongs to the MraZ family
C1C92_RS08465	COG0275	rRNA processing
C1C92_RS08470	COG3116	cell division
C1C92_RS08475	COG0768	penicillin binding
C1C92_RS08480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1C92_RS08485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C1C92_RS08490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1C92_RS08495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1C92_RS08500	COG0772	Belongs to the SEDS family
C1C92_RS08505	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1C92_RS08510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1C92_RS08515	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C1C92_RS08520	COG0849	cell division
C1C92_RS08525	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C1C92_RS08530	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C1C92_RS08540	COG0653	protein targeting
C1C92_RS08550	COG0494	nUDIX hydrolase
C1C92_RS08555	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C1C92_RS08560	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C1C92_RS08575	COG1459	type II secretion system
C1C92_RS08580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1C92_RS08605	COG2186	Transcriptional regulator
C1C92_RS08610	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C1C92_RS08615	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1C92_RS08620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1C92_RS08630	COG0840	transmembrane signaling receptor activity
C1C92_RS08635	COG0840	transmembrane signaling receptor activity
C1C92_RS08645	COG1049	propionate catabolic process, 2-methylcitrate cycle
C1C92_RS08650	COG2200	EAL domain
C1C92_RS08660	COG1280	lysine exporter protein (LysE YggA)
C1C92_RS08670	COG0523	cobalamin synthesis protein
C1C92_RS08675	COG0477	Major facilitator Superfamily
C1C92_RS08690	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1C92_RS08695	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C1C92_RS08740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C1C92_RS08760	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C1C92_RS08765	COG0732	type I restriction modification DNA specificity domain
C1C92_RS08770	COG1401	restriction endodeoxyribonuclease activity
C1C92_RS08770	COG1401	restriction endodeoxyribonuclease activity
C1C92_RS08780	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C1C92_RS08815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1C92_RS08830	COG1546	Belongs to the CinA family
C1C92_RS08835	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1C92_RS08840	COG2137	regulation of response to DNA damage stimulus
C1C92_RS08845	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1C92_RS08850	COG0527	aspartate kinase activity
C1C92_RS08855	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C1C92_RS08890	COG1686	Belongs to the peptidase S11 family
C1C92_RS08895	COG0586	Pfam SNARE associated Golgi protein
C1C92_RS08900	COG1253	flavin adenine dinucleotide binding
C1C92_RS08905	COG0525	valine-tRNA ligase activity
C1C92_RS08910	COG2927	DNA polymerase III (CHI subunit)
C1C92_RS08915	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1C92_RS08920	COG0795	lipopolysaccharide-transporting ATPase activity
C1C92_RS08925	COG0795	lipopolysaccharide-transporting ATPase activity
C1C92_RS08945	COG0004	ammonium transporteR
C1C92_RS08950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1C92_RS08960	COG2165	general secretion pathway protein
C1C92_RS08965	COG0084	hydrolase, TatD family'
C1C92_RS08970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1C92_RS08980	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C1C92_RS08985	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C1C92_RS08990	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C1C92_RS08995	COG0813	purine-nucleoside phosphorylase activity
C1C92_RS09000	COG3447	MASE1 domain protein
C1C92_RS09000	COG5001	Diguanylate cyclase
C1C92_RS09000	COG5002	protein histidine kinase activity
C1C92_RS09010	COG0560	Phosphoserine phosphatase
C1C92_RS09025	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C1C92_RS09035	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C1C92_RS09040	COG0776	regulation of translation
C1C92_RS09055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1C92_RS09060	COG0735	belongs to the Fur family
C1C92_RS09080	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C1C92_RS09085	COG0513	Belongs to the DEAD box helicase family
C1C92_RS09090	COG3022	response to hydroperoxide
C1C92_RS09105	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C1C92_RS09110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C1C92_RS09115	COG0762	integral membrane protein
C1C92_RS09120	COG1872	DUF167
C1C92_RS09140	COG3112	Uncharacterised protein family (UPF0231)
C1C92_RS09145	COG3835	regulator
C1C92_RS09150	COG2610	gluconate transmembrane transporter activity
C1C92_RS09155	COG1929	Belongs to the glycerate kinase type-1 family
C1C92_RS09170	COG0583	DNA-binding transcription factor activity
C1C92_RS09175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1C92_RS09190	COG0347	Belongs to the P(II) protein family
C1C92_RS09195	COG1840	ABC-type Fe3 transport system, periplasmic component
C1C92_RS09205	COG3842	ATPase activity
C1C92_RS09210	COG2837	iron assimilation
C1C92_RS09215	COG1438	arginine binding
C1C92_RS09220	COG1126	abc transporter atp-binding protein
C1C92_RS09225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C92_RS09230	COG4215	(ABC) transporter
C1C92_RS09235	COG4160	amino acid transport
C1C92_RS09240	COG0039	L-malate dehydrogenase activity
C1C92_RS09245	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C1C92_RS09250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1C92_RS09250	COG1017	nitric oxide dioxygenase activity
C1C92_RS09260	COG4536	flavin adenine dinucleotide binding
C1C92_RS09265	COG4137	Cytochrome C assembly protein
C1C92_RS09270	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C1C92_RS09275	COG0228	four-way junction DNA binding
C1C92_RS09280	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C1C92_RS09285	COG0336	Belongs to the RNA methyltransferase TrmD family
C1C92_RS09290	COG0335	large ribosomal subunit rRNA binding
C1C92_RS09305	COG1051	belongs to the nudix hydrolase family
C1C92_RS09315	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1C92_RS09320	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C1C92_RS09325	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1C92_RS09335	COG0583	DNA-binding transcription factor activity
C1C92_RS09340	COG0640	Transcriptional regulator
C1C92_RS09345	COG0268	Binds directly to 16S ribosomal RNA
C1C92_RS09350	COG0728	peptidoglycan biosynthetic process
C1C92_RS09355	COG0196	riboflavin kinase activity
C1C92_RS09360	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C1C92_RS09365	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C1C92_RS09370	COG1047	Peptidyl-prolyl cis-trans
C1C92_RS09375	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1C92_RS09415	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C1C92_RS09415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1C92_RS09430	COG1854	S-ribosylhomocysteine lyase activity
C1C92_RS09435	COG3706	GGDEF domain
C1C92_RS09440	COG0557	exoribonuclease II activity
C1C92_RS09445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1C92_RS09455	COG2153	protein acetylation
C1C92_RS09465	COG1914	H( )-stimulated, divalent metal cation uptake system
C1C92_RS09470	COG0360	Binds together with S18 to 16S ribosomal RNA
C1C92_RS09475	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1C92_RS09480	COG0359	binds to the 23S rRNA
C1C92_RS09520	COG1238	metal cluster binding
C1C92_RS09525	COG0612	Peptidase, M16
C1C92_RS09530	COG2918	glutathione biosynthetic process
C1C92_RS09535	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C1C92_RS09540	COG1027	Aspartate ammonia-lyase
C1C92_RS09545	COG3030	protein affecting phage T7 exclusion by the F plasmid
C1C92_RS09550	COG0534	Mate efflux family protein
C1C92_RS09555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1C92_RS09560	COG0459	protein refolding
C1C92_RS09580	COG0564	pseudouridine synthase activity
C1C92_RS09585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1C92_RS09615	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C1C92_RS09625	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C1C92_RS09630	COG4208	sulfate ABC transporter
C1C92_RS09635	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C1C92_RS09640	COG0583	DNA-binding transcription factor activity
C1C92_RS09645	COG3397	chitin binding
C1C92_RS09650	COG0840	transmembrane signaling receptor activity
C1C92_RS09675	COG1328	CTP reductase activity
C1C92_RS09680	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1C92_RS09695	COG1448	Aminotransferase
C1C92_RS09720	COG1215	transferase activity, transferring glycosyl groups
C1C92_RS09730	COG3118	belongs to the thioredoxin family
C1C92_RS09730	COG0457	Tetratricopeptide repeat
C1C92_RS09735	COG3118	belongs to the thioredoxin family
C1C92_RS09735	COG0457	Tetratricopeptide repeat
C1C92_RS09775	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C1C92_RS09780	COG0513	Belongs to the DEAD box helicase family
C1C92_RS09785	COG0840	transmembrane signaling receptor activity
C1C92_RS09795	COG4166	transmembrane transport
C1C92_RS09810	COG1024	Enoyl-CoA hydratase
C1C92_RS09825	COG4221	oxidoreductase activity
C1C92_RS09830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1C92_RS09835	COG0442	prolyl-tRNA aminoacylation
C1C92_RS09840	COG0840	transmembrane signaling receptor activity
C1C92_RS09845	COG0632	four-way junction helicase activity
C1C92_RS09850	COG2255	four-way junction helicase activity
C1C92_RS09860	COG1271	oxidase subunit
C1C92_RS09865	COG1294	oxidase, subunit
C1C92_RS09870	COG4890	Cyd operon protein YbgT
C1C92_RS09875	COG3790	cyd operon protein YbgE
C1C92_RS09880	COG0824	Thioesterase
C1C92_RS09885	COG0811	peptide transport
C1C92_RS09900	COG0823	Involved in the tonB-independent uptake of proteins
C1C92_RS09905	COG2885	chlorophyll binding
C1C92_RS09910	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C1C92_RS09985	COG0840	transmembrane signaling receptor activity
C1C92_RS09990	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C1C92_RS10000	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1C92_RS10005	COG1640	4-alpha-glucanotransferase
C1C92_RS10010	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1C92_RS10040	COG2130	NADP-dependent
C1C92_RS10045	COG1846	Transcriptional regulator
C1C92_RS10075	COG0561	phosphatase activity
C1C92_RS10090	COG0733	neurotransmitter:sodium symporter activity
C1C92_RS10095	COG0733	neurotransmitter:sodium symporter activity
C1C92_RS10110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1C92_RS10125	COG1794	racemase activity, acting on amino acids and derivatives
C1C92_RS10135	COG1022	Amp-dependent synthetase and ligase
C1C92_RS10145	COG0456	acetyltransferase
C1C92_RS10160	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C1C92_RS10165	COG5001	Diguanylate cyclase
C1C92_RS10165	COG5002	protein histidine kinase activity
C1C92_RS10190	COG0456	acetyltransferase
C1C92_RS10210	COG2957	Belongs to the agmatine deiminase family
C1C92_RS10215	COG0154	amidase activity
C1C92_RS10250	COG2207	Transcriptional regulator
C1C92_RS10250	COG1917	Cupin 2, conserved barrel domain protein
C1C92_RS10260	COG0513	Belongs to the DEAD box helicase family
C1C92_RS10265	COG2199	diguanylate cyclase activity
C1C92_RS10265	COG2203	Gaf domain
C1C92_RS10300	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
C1C92_RS10310	COG0577	efflux transmembrane transporter activity
C1C92_RS10310	COG1136	(ABC) transporter
C1C92_RS10315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C92_RS10320	COG0745	RESPONSE REGULATOR receiver
C1C92_RS10325	COG2205	protein histidine kinase activity
C1C92_RS10380	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1C92_RS10390	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C1C92_RS10395	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C1C92_RS10400	COG1178	ABC-type Fe3 transport system permease component
C1C92_RS10405	COG4143	(ABC) transporter
C1C92_RS10420	COG0066	3-isopropylmalate dehydratase activity
C1C92_RS10425	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1C92_RS10430	COG0473	3-isopropylmalate dehydrogenase activity
C1C92_RS10435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1C92_RS10445	COG0671	phosphoesterase, PA-phosphatase related
C1C92_RS10460	COG0028	Belongs to the TPP enzyme family
C1C92_RS10465	COG0440	acetolactate synthase activity
C1C92_RS10470	COG0857	belongs to the CobB CobQ family
C1C92_RS10470	COG0280	phosphate acetyltransferase
C1C92_RS10475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1C92_RS10480	COG3092	negative regulation of chromosome organization
C1C92_RS10485	COG3013	Belongs to the UPF0304 family
C1C92_RS10490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C1C92_RS10495	COG2716	regulation of RNA biosynthetic process
C1C92_RS10500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1C92_RS10505	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C1C92_RS10510	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1C92_RS10525	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C1C92_RS10545	COG0784	Response regulator, receiver
C1C92_RS10545	COG2198	Histidine kinase
C1C92_RS10545	COG5002	protein histidine kinase activity
C1C92_RS10550	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C1C92_RS10570	COG0840	transmembrane signaling receptor activity
C1C92_RS10580	COG1464	Belongs to the NlpA lipoprotein family
C1C92_RS10585	COG2011	ABC-type metal ion transport system permease component
C1C92_RS10590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1C92_RS10610	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C1C92_RS10610	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C1C92_RS10615	COG0802	atpase or kinase
C1C92_RS10625	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C1C92_RS10630	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C1C92_RS10635	COG1923	regulation of RNA biosynthetic process
C1C92_RS10640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1C92_RS10645	COG0330	HflC and HflK could
C1C92_RS10650	COG0330	HflC and HflK could
C1C92_RS10655	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C1C92_RS10660	COG0142	geranyltranstransferase activity
C1C92_RS10665	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1C92_RS10670	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C1C92_RS10675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C1C92_RS10680	COG3314	Sporulation integral membrane protein YlbJ
C1C92_RS10685	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1C92_RS10690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1C92_RS10700	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C1C92_RS10705	COG2967	ApaG domain
C1C92_RS10710	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C1C92_RS10715	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C1C92_RS10725	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C1C92_RS10730	COG3178	'Phosphotransferase
C1C92_RS10735	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C1C92_RS10740	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1C92_RS10745	COG2252	PERMEase
C1C92_RS10755	COG0488	(ABC) transporter
C1C92_RS10760	COG0582	viral genome integration into host DNA
C1C92_RS10915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1C92_RS10920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1C92_RS10925	COG2135	peptidase activity
C1C92_RS10970	COG4626	Terminase
C1C92_RS10970	COG1802	Transcriptional regulator
C1C92_RS10985	COG0616	signal peptide processing
C1C92_RS11090	COG0741	lytic transglycosylase activity
C1C92_RS11095	COG0463	Glycosyl transferase, family 2
C1C92_RS11105	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C1C92_RS11130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1C92_RS11140	COG3721	Heme iron utilization protein
C1C92_RS11145	COG0748	coenzyme F420 binding
C1C92_RS11170	COG2814	Major facilitator Superfamily
C1C92_RS11175	COG2205	protein histidine kinase activity
C1C92_RS11175	COG2202	Pas domain
C1C92_RS11185	COG2226	methyltransferase
C1C92_RS11195	COG1765	OsmC-like protein
C1C92_RS11210	COG3954	Phosphoribulokinase
C1C92_RS11215	COG3089	Belongs to the UPF0270 family
C1C92_RS11220	COG2203	Gaf domain
C1C92_RS11220	COG5001	Diguanylate cyclase
C1C92_RS11220	COG3706	GGDEF domain
C1C92_RS11220	COG4251	negative regulation of phosphorylation
C1C92_RS11225	COG0429	hydrolase of the alpha beta-hydrolase fold
C1C92_RS11230	COG0784	Response regulator, receiver
C1C92_RS11230	COG0835	chemotaxis
C1C92_RS11240	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C1C92_RS11245	COG1047	Peptidyl-prolyl cis-trans
C1C92_RS11250	COG2900	Belongs to the SlyX family
C1C92_RS11260	COG0545	Peptidyl-prolyl cis-trans isomerase
C1C92_RS11265	COG2204	response regulator
C1C92_RS11285	COG0737	Belongs to the 5'-nucleotidase family
C1C92_RS11300	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1C92_RS11305	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C1C92_RS11305	COG0506	proline dehydrogenase activity
C1C92_RS11305	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C1C92_RS11315	COG0114	fumarate hydratase activity
C1C92_RS11325	COG1566	PFAM secretion protein HlyD family protein
C1C92_RS11405	COG1280	lysine exporter protein (LysE YggA)
C1C92_RS11410	COG0826	peptidase U32
C1C92_RS11420	COG3813	Protein conserved in bacteria
C1C92_RS11440	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C1C92_RS11465	COG0300	oxidoreductase activity
C1C92_RS11485	COG2610	gluconate transmembrane transporter activity
C1C92_RS11490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1C92_RS11495	COG3622	Belongs to the hyi family
C1C92_RS11500	COG0235	Class ii aldolase
C1C92_RS11510	COG2084	Dehydrogenase
C1C92_RS11515	COG1349	DNA-binding transcription factor activity
C1C92_RS11525	COG2133	pyrroloquinoline quinone binding
C1C92_RS11560	COG4397	Mu-like prophage major head subunit gpT
C1C92_RS11590	COG0077	Prephenate dehydratase
C1C92_RS11590	COG1605	Chorismate mutase
C1C92_RS11615	COG3272	Protein of unknown function (DUF1722)
C1C92_RS11620	COG0789	Transcriptional regulator
C1C92_RS11625	COG0415	Belongs to the DNA photolyase family
C1C92_RS11635	COG4221	oxidoreductase activity
C1C92_RS11650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1C92_RS11675	COG0783	Belongs to the Dps family
C1C92_RS11680	COG1151	hydroxylamine reductase activity
C1C92_RS11685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1C92_RS11690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1C92_RS11710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1C92_RS11715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C92_RS11725	COG5002	protein histidine kinase activity
C1C92_RS11725	COG5000	phosphorelay sensor kinase activity
C1C92_RS11735	COG0659	secondary active sulfate transmembrane transporter activity
C1C92_RS11745	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C1C92_RS11750	COG1666	GTP binding
C1C92_RS11760	COG2211	Major facilitator Superfamily
C1C92_RS11770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1C92_RS11780	COG2813	Specifically methylates the guanine in position
C1C92_RS11785	COG0271	Belongs to the BolA IbaG family
C1C92_RS11790	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1C92_RS11795	COG1805	sodium ion transport
C1C92_RS11800	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1C92_RS11805	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1C92_RS11810	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1C92_RS11815	COG2871	sodium ion transport
C1C92_RS11820	COG1477	protein flavinylation
C1C92_RS11835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1C92_RS11840	COG0840	transmembrane signaling receptor activity
C1C92_RS11845	COG0583	DNA-binding transcription factor activity
C1C92_RS11860	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C1C92_RS11870	COG0473	3-isopropylmalate dehydrogenase activity
C1C92_RS11875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1C92_RS11880	COG1611	Belongs to the LOG family
C1C92_RS11895	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C1C92_RS11895	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C1C92_RS11905	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
C1C92_RS11930	COG3098	single-species biofilm formation
C1C92_RS11935	COG0564	pseudouridine synthase activity
C1C92_RS11945	COG4580	involved in the transport of maltose and maltodextrins
C1C92_RS11955	COG1263	PTS System
C1C92_RS11955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1C92_RS11965	COG2171	N-acyltransferase activity
C1C92_RS11970	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C1C92_RS11975	COG0024	Methionine aminopeptidase
C1C92_RS11980	COG0052	Belongs to the universal ribosomal protein uS2 family
C1C92_RS11985	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C1C92_RS11990	COG0528	UMP kinase activity
C1C92_RS11995	COG0233	cytoplasmic translational termination
C1C92_RS12000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1C92_RS12005	COG0575	Belongs to the CDS family
C1C92_RS12010	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C1C92_RS12015	COG0750	zinc metalloprotease
C1C92_RS12030	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1C92_RS12035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1C92_RS12040	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1C92_RS12045	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1C92_RS12050	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C1C92_RS12055	COG0587	DNA-directed DNA polymerase activity
C1C92_RS12060	COG0825	malonyl-CoA metabolic process
C1C92_RS12075	COG0814	amino acid
C1C92_RS12080	COG0531	amino acid
C1C92_RS12090	COG0488	(ABC) transporter
C1C92_RS12100	COG3590	peptidase
C1C92_RS12105	COG0037	tRNA processing
C1C92_RS12110	COG3706	GGDEF domain
C1C92_RS12155	COG0366	Alpha amylase catalytic
C1C92_RS12170	COG0463	Glycosyl transferase, family 2
C1C92_RS12185	COG2989	Protein conserved in bacteria
C1C92_RS12190	COG3108	Peptidase M15
C1C92_RS12200	COG2860	membrane
C1C92_RS12215	COG3115	cell septum assembly
C1C92_RS12220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1C92_RS12230	COG1328	CTP reductase activity
C1C92_RS12235	COG0602	queuosine metabolic process
C1C92_RS12260	COG1566	PFAM secretion protein HlyD family protein
C1C92_RS12270	COG3290	protein histidine kinase activity
C1C92_RS12285	COG0667	Aldo Keto reductase
C1C92_RS12295	COG0697	spore germination
C1C92_RS12310	COG3284	Transcriptional regulator
C1C92_RS12315	COG3706	GGDEF domain
C1C92_RS12320	COG0346	lactoylglutathione lyase activity
C1C92_RS12325	COG0745	RESPONSE REGULATOR receiver
C1C92_RS12330	COG5002	protein histidine kinase activity
C1C92_RS12340	COG4783	chaperone-mediated protein folding
C1C92_RS12360	COG0545	Peptidyl-prolyl cis-trans isomerase
C1C92_RS12365	COG1131	(ABC) transporter
C1C92_RS12370	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C1C92_RS12380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C92_RS12385	COG4597	amino acid ABC transporter
C1C92_RS12390	COG0765	amino acid transport
C1C92_RS12395	COG1126	abc transporter atp-binding protein
C1C92_RS12405	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C1C92_RS12410	COG0678	peroxiredoxin activity
C1C92_RS12420	COG0019	diaminopimelate decarboxylase activity
C1C92_RS12425	COG1115	amino acid carrier protein
C1C92_RS12430	COG0095	Lipoate-protein ligase
C1C92_RS12435	COG2233	PERMEase
C1C92_RS12455	COG2207	Transcriptional regulator
C1C92_RS12460	COG0281	malic enzyme
C1C92_RS12490	COG0733	neurotransmitter:sodium symporter activity
C1C92_RS12495	COG1752	Esterase of the alpha-beta hydrolase superfamily
C1C92_RS12500	COG3706	GGDEF domain
C1C92_RS12510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1C92_RS12515	COG1032	radical SAM domain protein
C1C92_RS12520	COG3903	Transcriptional regulator
C1C92_RS12520	COG2319	Wd-40 repeat
C1C92_RS12540	COG0673	inositol 2-dehydrogenase activity
C1C92_RS12545	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C1C92_RS12550	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1C92_RS12580	COG0741	lytic transglycosylase activity
C1C92_RS12580	COG0739	heme binding
C1C92_RS12580	COG1196	nuclear chromosome segregation
C1C92_RS12605	COG0788	formyltetrahydrofolate deformylase activity
C1C92_RS12610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1C92_RS12620	COG3118	belongs to the thioredoxin family
C1C92_RS12630	COG0791	NLP P60 protein
C1C92_RS12635	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C1C92_RS12650	COG1376	ErfK ybiS ycfS ynhG family protein
C1C92_RS12650	COG1388	LysM domain
C1C92_RS12710	COG0583	DNA-binding transcription factor activity
C1C92_RS12740	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1C92_RS12815	COG1203	CRISPR-associated helicase, Cas3
C1C92_RS12820	COG1518	maintenance of DNA repeat elements
C1C92_RS12855	COG2003	Belongs to the UPF0758 family
C1C92_RS12900	COG3311	Transcriptional regulator
C1C92_RS12915	COG0582	viral genome integration into host DNA
C1C92_RS12920	COG0784	Response regulator, receiver
C1C92_RS12920	COG2205	protein histidine kinase activity
C1C92_RS12945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C92_RS12945	COG2205	protein histidine kinase activity
C1C92_RS12950	COG3384	dioxygenase
C1C92_RS12960	COG1283	sodium-dependent phosphate transmembrane transporter activity
C1C92_RS12970	COG0531	amino acid
C1C92_RS12975	COG0531	amino acid
C1C92_RS12990	COG1012	belongs to the aldehyde dehydrogenase family
C1C92_RS12995	COG1917	Cupin 2, conserved barrel domain protein
C1C92_RS12995	COG1396	sequence-specific DNA binding
C1C92_RS13000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1C92_RS13035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1C92_RS13035	COG4651	solute:proton antiporter activity
C1C92_RS13050	COG2974	May be involved in recombination
C1C92_RS13060	COG0420	3'-5' exonuclease activity
C1C92_RS13070	COG3038	cytochrome b561
C1C92_RS13075	COG2190	(PTS) system
C1C92_RS13085	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1C92_RS13090	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1C92_RS13095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1C92_RS13110	COG1720	tRNA m6t6A37 methyltransferase activity
C1C92_RS13130	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C1C92_RS13135	COG4988	ABC transporter
C1C92_RS13150	COG0745	RESPONSE REGULATOR receiver
C1C92_RS13160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1C92_RS13175	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C1C92_RS13180	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C1C92_RS13195	COG0083	homoserine kinase activity
C1C92_RS13200	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C1C92_RS13220	COG1943	Transposase
C1C92_RS13230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1C92_RS13240	COG3220	belongs to the UPF0276 family
C1C92_RS13275	COG1289	transmembrane transporter activity
C1C92_RS13285	COG0746	molybdenum cofactor guanylyltransferase activity
C1C92_RS13320	COG3264	Mechanosensitive ion channel
C1C92_RS13320	COG1196	nuclear chromosome segregation
C1C92_RS13330	COG2850	peptidyl-arginine hydroxylation
C1C92_RS13335	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1C92_RS13340	COG2915	High frequency lysogenization protein hflD homolog
C1C92_RS13345	COG0482	sulfurtransferase activity
C1C92_RS13355	COG1187	pseudouridine synthase activity
C1C92_RS13360	COG0456	acetyltransferase
C1C92_RS13390	COG0538	isocitrate dehydrogenase activity
C1C92_RS13400	COG3048	D-serine ammonia-lyase activity
C1C92_RS13405	COG0583	DNA-binding transcription factor activity
C1C92_RS13410	COG2916	Histone family protein nucleoid-structuring protein H-NS
C1C92_RS13415	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1C92_RS13420	COG2375	cellular response to nickel ion
C1C92_RS13425	COG1538	Outer membrane efflux protein
C1C92_RS13430	COG1136	(ABC) transporter
C1C92_RS13430	COG0577	efflux transmembrane transporter activity
C1C92_RS13435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C92_RS13445	COG0497	DNA recombination
C1C92_RS13455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C1C92_RS13460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C1C92_RS13465	COG0443	Heat shock 70 kDa protein
C1C92_RS13470	COG0484	heat shock protein binding
C1C92_RS13500	COG1285	pathogenesis
C1C92_RS13510	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1C92_RS13520	COG0640	Transcriptional regulator
C1C92_RS13530	COG2391	methyltransferase activity
C1C92_RS13550	COG0095	Lipoate-protein ligase
C1C92_RS13565	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1C92_RS13570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C92_RS13580	COG0708	Exodeoxyribonuclease III
C1C92_RS13590	COG0745	RESPONSE REGULATOR receiver
C1C92_RS13605	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
C1C92_RS13620	COG1846	Transcriptional regulator
C1C92_RS13640	COG0583	DNA-binding transcription factor activity
C1C92_RS13645	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1C92_RS13650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C1C92_RS13660	COG1845	cytochrome c oxidase, subunit III
C1C92_RS13665	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C1C92_RS13670	COG0109	protoheme IX farnesyltransferase activity
C1C92_RS13680	COG2814	Major facilitator Superfamily
C1C92_RS13685	COG5507	3-demethylubiquinone-9 3-methyltransferase
C1C92_RS13695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1C92_RS13700	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C1C92_RS13705	COG4521	taurine ABC transporter
C1C92_RS13740	COG1988	membrane-bound metal-dependent
C1C92_RS13765	COG0133	tryptophan synthase activity
C1C92_RS13770	COG0135	phosphoribosylanthranilate isomerase activity
C1C92_RS13770	COG0134	indole-3-glycerol-phosphate synthase activity
C1C92_RS13775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1C92_RS13780	COG0512	Glutamine amidotransferase of anthranilate synthase
C1C92_RS13780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1C92_RS13785	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1C92_RS13790	COG0613	PHP domain protein
C1C92_RS13795	COG0009	L-threonylcarbamoyladenylate synthase
C1C92_RS13805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C1C92_RS13820	COG1946	Acyl-CoA thioesterase
C1C92_RS13835	COG1309	transcriptional regulator
C1C92_RS13840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1C92_RS13845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1C92_RS13860	COG3039	Transposase
C1C92_RS13910	COG2003	Belongs to the UPF0758 family
C1C92_RS13925	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C1C92_RS13940	COG0583	DNA-binding transcription factor activity
C1C92_RS13945	COG4584	PFAM Integrase catalytic
C1C92_RS13950	COG1484	DNA-dependent DNA replication
C1C92_RS13985	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C1C92_RS13995	COG1960	acyl-CoA dehydrogenase activity
C1C92_RS14000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1C92_RS14010	COG0469	pyruvate kinase activity
C1C92_RS14015	COG1737	Transcriptional regulator
C1C92_RS14040	COG1091	dTDP-4-dehydrorhamnose reductase activity
C1C92_RS14075	COG2755	lipolytic protein G-D-S-L family
C1C92_RS14075	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1C92_RS14090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1C92_RS14110	COG2244	polysaccharide biosynthetic process
C1C92_RS14125	COG0463	Glycosyl transferase, family 2
C1C92_RS14130	COG2801	Transposase and inactivated derivatives
C1C92_RS14140	COG0438	transferase activity, transferring glycosyl groups
C1C92_RS14145	COG1442	glycosyl transferase family 8
C1C92_RS14145	COG1216	Glycosyl transferase, family 2
C1C92_RS14155	COG0438	transferase activity, transferring glycosyl groups
C1C92_RS14160	COG1596	polysaccharide export
C1C92_RS14165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1C92_RS14170	COG0489	protein tyrosine kinase activity
C1C92_RS14170	COG3206	protein involved in exopolysaccharide biosynthesis
C1C92_RS14190	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1C92_RS14200	COG3132	Protein of unknown function, DUF480
C1C92_RS14225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C1C92_RS14240	COG1278	Cold shock
C1C92_RS14270	COG0697	spore germination
C1C92_RS14280	COG0675	Transposase, IS605 OrfB family
C1C92_RS14285	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1C92_RS14300	COG4166	transmembrane transport
C1C92_RS14310	COG0675	Transposase, IS605 OrfB family
C1C92_RS14315	COG0622	Phosphoesterase
C1C92_RS14330	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C1C92_RS14335	COG0835	chemotaxis
C1C92_RS14335	COG0784	Response regulator, receiver
C1C92_RS14340	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C1C92_RS14345	COG1815	bacterial-type flagellum-dependent cell motility
C1C92_RS14360	COG4786	Flagellar basal body rod
C1C92_RS14375	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C1C92_RS14380	COG1706	bacterial-type flagellum-dependent cell motility
C1C92_RS14400	COG2239	Acts as a magnesium transporter
C1C92_RS14410	COG0675	Transposase, IS605 OrfB family
C1C92_RS14425	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1C92_RS14430	COG2716	regulation of RNA biosynthetic process
C1C92_RS14455	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C1C92_RS14460	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C1C92_RS14465	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C1C92_RS14470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C1C92_RS14490	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C1C92_RS14505	COG0590	tRNA wobble adenosine to inosine editing
C1C92_RS14510	COG0573	inorganic phosphate transmembrane transporter activity
C1C92_RS14515	COG0581	inorganic phosphate transmembrane transporter activity
C1C92_RS14520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1C92_RS14525	COG0704	Plays a role in the regulation of phosphate uptake
C1C92_RS14530	COG1253	flavin adenine dinucleotide binding
C1C92_RS14545	COG0531	amino acid
C1C92_RS14560	COG1126	abc transporter atp-binding protein
C1C92_RS14565	COG0765	amino acid transport
C1C92_RS14570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C92_RS14580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1C92_RS14600	COG1785	Belongs to the alkaline phosphatase family
C1C92_RS14605	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C1C92_RS14610	COG0477	Major facilitator Superfamily
C1C92_RS14615	COG0123	including yeast histone deacetylase and acetoin utilization protein
C1C92_RS14625	COG1199	ATP-dependent helicase activity
C1C92_RS14640	COG1448	Aminotransferase
C1C92_RS14645	COG0433	COG0433 Predicted ATPase
C1C92_RS14665	COG1132	(ABC) transporter
C1C92_RS14670	COG1663	tetraacyldisaccharide 4'-kinase activity
C1C92_RS14675	COG2835	tetraacyldisaccharide 4'-kinase activity
C1C92_RS14680	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C1C92_RS14685	COG2197	response regulator
C1C92_RS14690	COG0322	excinuclease ABC activity
C1C92_RS14725	COG0604	alcohol dehydrogenase
C1C92_RS14730	COG1309	transcriptional regulator
C1C92_RS14735	COG2261	transglycosylase associated protein
C1C92_RS14740	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1C92_RS14750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1C92_RS14755	COG0215	cysteine-tRNA ligase activity
C1C92_RS14780	COG2203	Gaf domain
C1C92_RS14780	COG2199	diguanylate cyclase activity
C1C92_RS14815	COG2119	membrane
C1C92_RS14820	COG0023	Translation Initiation Factor
C1C92_RS14830	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C1C92_RS14855	COG4139	cobalamin transport
C1C92_RS14860	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
C1C92_RS14870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1C92_RS14875	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C1C92_RS14880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1C92_RS14885	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C1C92_RS14890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C1C92_RS14900	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C1C92_RS14905	COG0505	Belongs to the CarA family
C1C92_RS14910	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1C92_RS14915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1C92_RS14920	COG3706	GGDEF domain
C1C92_RS14960	COG0513	Belongs to the DEAD box helicase family
C1C92_RS14970	COG4104	PAAR repeat-containing protein
C1C92_RS14995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C92_RS15000	COG0765	amino acid transport
C1C92_RS15005	COG1126	abc transporter atp-binding protein
C1C92_RS15010	COG0493	'glutamate synthase
C1C92_RS15015	COG0067	glutamate synthase
C1C92_RS15015	COG0070	glutamate synthase
C1C92_RS15015	COG0069	glutamate synthase activity
C1C92_RS15020	COG1242	4 iron, 4 sulfur cluster binding
C1C92_RS15065	COG1113	amino acid transport
C1C92_RS15075	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C1C92_RS15080	COG0574	Belongs to the PEP-utilizing enzyme family
C1C92_RS15080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1C92_RS15085	COG1119	ATPase activity
C1C92_RS15105	COG1464	Belongs to the NlpA lipoprotein family
C1C92_RS15115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1C92_RS15120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1C92_RS15130	COG0101	tRNA pseudouridine synthase activity
C1C92_RS15135	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C1C92_RS15140	COG0285	dihydrofolate synthase activity
C1C92_RS15145	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C1C92_RS15150	COG2920	part of a sulfur-relay system
C1C92_RS15155	COG1289	transmembrane transporter activity
C1C92_RS15160	COG0670	Belongs to the BI1 family
C1C92_RS15200	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C1C92_RS15205	COG0840	transmembrane signaling receptor activity
C1C92_RS15210	COG5001	Diguanylate cyclase
C1C92_RS15215	COG0564	pseudouridine synthase activity
C1C92_RS15230	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C1C92_RS15240	COG0625	glutathione transferase activity
C1C92_RS15255	COG0367	asparagine synthase
C1C92_RS15265	COG0647	UMP catabolic process
C1C92_RS15270	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1C92_RS15275	COG0604	alcohol dehydrogenase
C1C92_RS15280	COG1902	pentaerythritol trinitrate reductase activity
C1C92_RS15285	COG1253	flavin adenine dinucleotide binding
C1C92_RS15295	COG0247	lactate metabolic process
C1C92_RS15295	COG0277	FAD linked oxidase domain protein
C1C92_RS15305	COG2050	protein possibly involved in aromatic compounds catabolism
C1C92_RS15320	COG5001	Diguanylate cyclase
C1C92_RS15325	COG0583	DNA-binding transcription factor activity
C1C92_RS15330	COG2814	Major facilitator Superfamily
C1C92_RS15335	COG2056	Na+-H+ antiporter family
C1C92_RS15340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1C92_RS15355	COG0483	inositol monophosphate 1-phosphatase activity
C1C92_RS15365	COG0625	glutathione transferase activity
C1C92_RS15370	COG0625	glutathione transferase activity
C1C92_RS15380	COG0601	transmembrane transport
C1C92_RS15385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1C92_RS15390	COG0444	Belongs to the ABC transporter superfamily
C1C92_RS15395	COG2814	Major facilitator Superfamily
C1C92_RS15415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1C92_RS15420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1C92_RS15425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1C92_RS15430	COG0509	glycine decarboxylation via glycine cleavage system
C1C92_RS15435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1C92_RS15435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1C92_RS15460	COG3634	alkyl hydroperoxide reductase activity
C1C92_RS15465	COG0450	alkyl hydroperoxide reductase
C1C92_RS15470	COG0517	IMP dehydrogenase activity
C1C92_RS15475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C1C92_RS15480	COG0343	queuine tRNA-ribosyltransferase activity
C1C92_RS15485	COG1862	Preprotein translocase
C1C92_RS15490	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1C92_RS15495	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1C92_RS15500	COG2897	thiosulfate sulfurtransferase activity
C1C92_RS15510	COG0826	peptidase U32
C1C92_RS15515	COG0826	peptidase U32
C1C92_RS15520	COG3154	lipid carrier protein
C1C92_RS15535	COG1104	cysteine desulfurase activity
C1C92_RS15540	COG0822	iron-sulfur transferase activity
C1C92_RS15550	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1C92_RS15555	COG0443	Heat shock 70 kDa protein
C1C92_RS15560	COG0633	Ferredoxin
C1C92_RS15570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1C92_RS15575	COG0105	UTP biosynthetic process
C1C92_RS15580	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C1C92_RS15590	COG1426	Protein conserved in bacteria
C1C92_RS15600	COG0124	histidyl-tRNA synthetase
C1C92_RS15605	COG2976	Protein conserved in bacteria
C1C92_RS15610	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1C92_RS15615	COG1160	GTP binding
C1C92_RS15620	COG1645	bacterial-type flagellum-dependent swarming motility
C1C92_RS15625	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C1C92_RS15630	COG0047	phosphoribosylformylglycinamidine synthase activity
C1C92_RS15630	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1C92_RS15635	COG1007	ATP synthesis coupled electron transport
C1C92_RS15640	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1C92_RS15650	COG0713	ATP synthesis coupled electron transport
C1C92_RS15655	COG0839	Belongs to the complex I subunit 6 family
C1C92_RS15660	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1C92_RS15665	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C1C92_RS15670	COG1034	ATP synthesis coupled electron transport
C1C92_RS15685	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1C92_RS15685	COG0649	NAD binding
C1C92_RS15690	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1C92_RS15695	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1C92_RS15700	COG1360	Flagellar Motor Protein
C1C92_RS15705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1C92_RS15720	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C1C92_RS15730	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
C1C92_RS15740	COG0724	RNA recognition motif
C1C92_RS15745	COG4989	oxidoreductase activity
C1C92_RS15770	COG0745	RESPONSE REGULATOR receiver
C1C92_RS15775	COG0583	DNA-binding transcription factor activity
C1C92_RS15785	COG5001	Diguanylate cyclase
C1C92_RS15785	COG3300	MHYT domain
C1C92_RS15790	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C1C92_RS15820	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1C92_RS15825	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C1C92_RS15830	COG0539	negative regulation of cytoplasmic translation
C1C92_RS15835	COG0776	regulation of translation
C1C92_RS15845	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C1C92_RS15865	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C1C92_RS15870	COG0602	queuosine metabolic process
C1C92_RS15875	COG3530	Putative quorum-sensing-regulated virulence factor
C1C92_RS15880	COG2096	Adenosyltransferase
C1C92_RS15885	COG2916	Histone family protein nucleoid-structuring protein H-NS
C1C92_RS15890	COG1757	Na H antiporter
C1C92_RS15895	COG1435	thymidine kinase activity
C1C92_RS15915	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C1C92_RS15930	COG1349	DNA-binding transcription factor activity
C1C92_RS15935	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C1C92_RS15955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1C92_RS15960	COG0626	cystathionine gamma-synthase activity
C1C92_RS15970	COG2910	NAD(P)H-binding
C1C92_RS15975	COG0583	DNA-binding transcription factor activity
C1C92_RS15980	COG4977	sequence-specific DNA binding
C1C92_RS15980	COG1917	Cupin 2, conserved barrel domain protein
C1C92_RS15985	COG2200	EAL domain
C1C92_RS15990	COG3706	GGDEF domain
C1C92_RS15995	COG4774	siderophore transport
C1C92_RS16005	COG0583	DNA-binding transcription factor activity
C1C92_RS16010	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C1C92_RS16020	COG0517	IMP dehydrogenase activity
C1C92_RS16020	COG0617	tRNA 3'-terminal CCA addition
C1C92_RS16020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C1C92_RS16025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1C92_RS16030	COG3046	protein related to deoxyribodipyrimidine photolyase
C1C92_RS16045	COG3088	subunit of a heme lyase
C1C92_RS16045	COG4235	cytochrome complex assembly
C1C92_RS16050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1C92_RS16055	COG1138	Cytochrome C-type biogenesis protein
C1C92_RS16060	COG3301	Polysulphide reductase, NrfD
C1C92_RS16065	COG0437	4 iron, 4 sulfur cluster binding
C1C92_RS16070	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C1C92_RS16085	COG0247	lactate metabolic process
C1C92_RS16090	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C1C92_RS16095	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C1C92_RS16100	COG3012	SEC-C Motif Domain Protein
C1C92_RS16105	COG0840	transmembrane signaling receptor activity
C1C92_RS16110	COG1846	Transcriptional regulator
C1C92_RS16110	COG1940	carbohydrate kinase activity
C1C92_RS16115	COG3290	protein histidine kinase activity
C1C92_RS16120	COG4565	transcriptional regulatory protein
C1C92_RS16135	COG3181	Tripartite tricarboxylate transporter family receptor
C1C92_RS16140	COG0739	heme binding
C1C92_RS16140	COG1196	nuclear chromosome segregation
C1C92_RS16140	COG0741	lytic transglycosylase activity
C1C92_RS16145	COG0569	domain protein
C1C92_RS16145	COG2985	domain, Protein
C1C92_RS16160	COG0556	nucleotide-excision repair
C1C92_RS16170	COG0586	Pfam SNARE associated Golgi protein
C1C92_RS16175	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C1C92_RS16180	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1C92_RS16185	COG2186	Transcriptional regulator
C1C92_RS16190	COG2719	SpoVR family
C1C92_RS16195	COG2718	Belongs to the UPF0229 family
C1C92_RS16200	COG2766	serine protein kinase
C1C92_RS16205	COG0514	ATP-dependent DNA helicase (RecQ)
C1C92_RS16210	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C1C92_RS16215	COG0814	amino acid
C1C92_RS16245	COG0058	SHG alpha-glucan phosphorylase activity
C1C92_RS16255	COG0471	metal ion transport
C1C92_RS16260	COG3118	belongs to the thioredoxin family
C1C92_RS16270	COG1132	(ABC) transporter
C1C92_RS16275	COG1132	(ABC) transporter
C1C92_RS16295	COG2501	S4 domain
C1C92_RS16305	COG3243	poly(R)-hydroxyalkanoic acid synthase
C1C92_RS16325	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C1C92_RS16330	COG2329	Antibiotic biosynthesis monooxygenase
C1C92_RS16365	COG0513	Belongs to the DEAD box helicase family
C1C92_RS16370	COG0386	Belongs to the glutathione peroxidase family
C1C92_RS16380	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1C92_RS16385	COG3148	PFAM DTW domain containing protein
C1C92_RS16395	COG0730	response to heat
C1C92_RS16400	COG0583	DNA-binding transcription factor activity
C1C92_RS16415	COG3593	DNA synthesis involved in DNA repair
C1C92_RS16455	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1C92_RS16460	COG1011	Hydrolase
C1C92_RS16465	COG1473	amidohydrolase
C1C92_RS16470	COG0205	6-phosphofructokinase activity
C1C92_RS16480	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C1C92_RS16485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1C92_RS16495	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C1C92_RS16500	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C1C92_RS16530	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C1C92_RS16535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1C92_RS16550	COG0588	phosphoglycerate mutase activity
C1C92_RS16565	COG1280	lysine exporter protein (LysE YggA)
C1C92_RS16580	COG2824	Alkylphosphonate utilization operon protein PhnA
C1C92_RS16615	COG2840	Smr protein MutS2
C1C92_RS16620	COG2890	protein-(glutamine-N5) methyltransferase activity
C1C92_RS16625	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C1C92_RS16635	COG0513	Belongs to the DEAD box helicase family
C1C92_RS16640	COG5654	RES domain protein
C1C92_RS16650	COG0814	amino acid
C1C92_RS16655	COG1609	Transcriptional regulator
C1C92_RS16660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1C92_RS16660	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1C92_RS16665	COG1105	Belongs to the carbohydrate kinase PfkB family
C1C92_RS16670	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C1C92_RS16670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1C92_RS16670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1C92_RS16675	COG3313	Fe-S protein
C1C92_RS16680	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C1C92_RS16685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1C92_RS16690	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1C92_RS16695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1C92_RS16705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1C92_RS16730	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C1C92_RS16735	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C1C92_RS16740	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1C92_RS16745	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C1C92_RS16750	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C1C92_RS16755	COG0072	phenylalanine-tRNA ligase activity
C1C92_RS16755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1C92_RS16760	COG0776	regulation of translation
C1C92_RS16790	COG5001	Diguanylate cyclase
C1C92_RS16790	COG3300	MHYT domain
C1C92_RS16795	COG1609	Transcriptional regulator
C1C92_RS16800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1C92_RS16805	COG1879	ABC-type sugar transport system periplasmic component
C1C92_RS16810	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1C92_RS16815	COG1129	ABC transporter
C1C92_RS16820	COG1869	D-ribose catabolic process
C1C92_RS16825	COG0625	glutathione transferase activity
C1C92_RS16840	COG0037	tRNA processing
C1C92_RS16845	COG0589	response to stress
C1C92_RS16850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1C92_RS16865	COG2217	Heavy metal translocating P-type atpase
C1C92_RS16875	COG2010	Cytochrome c
C1C92_RS16890	COG3278	Belongs to the heme-copper respiratory oxidase family
C1C92_RS16900	COG1956	GAF domain-containing protein
C1C92_RS16905	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C1C92_RS16915	COG0308	aminopeptidase N
C1C92_RS16925	COG2902	Dehydrogenase
C1C92_RS16930	COG0167	dihydroorotate dehydrogenase activity
C1C92_RS16940	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1C92_RS16940	COG0116	Belongs to the methyltransferase superfamily
C1C92_RS16950	COG0488	(ABC) transporter
C1C92_RS16965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1C92_RS16970	COG1067	ATP-dependent peptidase activity
C1C92_RS16980	COG3141	response to X-ray
C1C92_RS16990	COG2995	paraquat-inducible protein a
C1C92_RS17000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1C92_RS17000	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C1C92_RS17035	COG0084	hydrolase, TatD family'
C1C92_RS17040	COG0470	DNA polymerase III
C1C92_RS17045	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C1C92_RS17050	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C1C92_RS17055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1C92_RS17060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1C92_RS17065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1C92_RS17070	COG1028	Short-chain dehydrogenase reductase Sdr
C1C92_RS17080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1C92_RS17085	COG0416	fatty acid biosynthetic process
C1C92_RS17090	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C1C92_RS17095	COG1399	metal-binding, possibly nucleic acid-binding protein
C1C92_RS17110	COG0564	pseudouridine synthase activity
C1C92_RS17115	COG1530	ribonuclease E activity
C1C92_RS17120	COG0306	phosphate transporter
C1C92_RS17125	COG0717	Belongs to the dCTP deaminase family
C1C92_RS17130	COG0572	uridine kinase
C1C92_RS17135	COG0489	protein tyrosine kinase activity
C1C92_RS17140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1C92_RS17140	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1C92_RS17145	COG0625	glutathione transferase activity
C1C92_RS17150	COG1254	Belongs to the acylphosphatase family
C1C92_RS17155	COG0840	transmembrane signaling receptor activity
C1C92_RS17160	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1C92_RS17175	COG0709	Synthesizes selenophosphate from selenide and ATP
C1C92_RS17180	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C1C92_RS17185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1C92_RS17190	COG3437	response regulator, receiver
C1C92_RS17210	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C1C92_RS17220	COG1643	Atp-dependent helicase
C1C92_RS17225	COG0617	tRNA 3'-terminal CCA addition
C1C92_RS17225	COG0517	IMP dehydrogenase activity
C1C92_RS17225	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C1C92_RS17230	COG2197	response regulator
C1C92_RS17240	COG3314	Sporulation integral membrane protein YlbJ
C1C92_RS17250	COG0583	DNA-binding transcription factor activity
C1C92_RS17255	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C1C92_RS17265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C1C92_RS17270	COG2832	Protein of unknown function (DUF454)
C1C92_RS17275	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1C92_RS17285	COG0697	spore germination
C1C92_RS17300	COG0318	PFAM AMP-dependent synthetase and ligase
C1C92_RS17305	COG0596	Alpha beta hydrolase
C1C92_RS17315	COG1214	PFAM Peptidase M22, glycoprotease
C1C92_RS17320	COG1199	ATP-dependent helicase activity
C1C92_RS17330	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C1C92_RS17335	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1C92_RS17340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1C92_RS17345	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1C92_RS17345	COG0131	Imidazoleglycerol-phosphate dehydratase
C1C92_RS17350	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1C92_RS17355	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C1C92_RS17360	COG3437	response regulator, receiver
C1C92_RS17370	COG2198	Histidine kinase
C1C92_RS17370	COG0784	Response regulator, receiver
C1C92_RS17370	COG2205	protein histidine kinase activity
C1C92_RS17375	COG0107	imidazoleglycerol-phosphate synthase activity
C1C92_RS17380	COG0140	phosphoribosyl-ATP diphosphatase activity
C1C92_RS17380	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C1C92_RS17390	COG2378	regulation of single-species biofilm formation
C1C92_RS17395	COG0318	PFAM AMP-dependent synthetase and ligase
C1C92_RS17400	COG3134	Outer membrane lipoprotein
C1C92_RS17415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1C92_RS17440	COG4681	YaeQ
C1C92_RS17450	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1C92_RS17450	COG1024	Enoyl-CoA hydratase
C1C92_RS17455	COG0183	Belongs to the thiolase family
C1C92_RS17460	COG0714	Associated with various cellular activities
C1C92_RS17500	COG2067	long-chain fatty acid transport protein
C1C92_RS17505	COG2067	long-chain fatty acid transport protein
C1C92_RS17510	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C1C92_RS17525	COG1301	dicarboxylic acid transport
C1C92_RS17530	COG3123	guanosine phosphorylase activity
C1C92_RS17535	COG1760	l-serine dehydratase
C1C92_RS17545	COG1760	l-serine dehydratase
C1C92_RS17550	COG2951	lytic endotransglycosylase activity
C1C92_RS17555	COG3100	YcgL domain-containing protein
C1C92_RS17560	COG0850	regulation of cytokinetic process
C1C92_RS17565	COG2894	cell division
C1C92_RS17570	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C1C92_RS17575	COG3099	Belongs to the UPF0263 family
C1C92_RS17580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1C92_RS17600	COG2996	Protein conserved in bacteria
C1C92_RS17625	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C1C92_RS17630	COG0697	spore germination
C1C92_RS17635	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C1C92_RS17640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1C92_RS17655	COG0307	riboflavin synthase, alpha
C1C92_RS17665	COG0534	Mate efflux family protein
C1C92_RS17695	COG0417	DNA replication proofreading
C1C92_RS17710	COG1560	Kdo2-lipid A biosynthetic process
C1C92_RS17715	COG1560	Kdo2-lipid A biosynthetic process
C1C92_RS17725	COG0583	DNA-binding transcription factor activity
C1C92_RS17730	COG0673	inositol 2-dehydrogenase activity
C1C92_RS17735	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C1C92_RS17755	COG0583	DNA-binding transcription factor activity
C1C92_RS17765	COG2723	6-phospho-beta-galactosidase activity
C1C92_RS17770	COG0583	DNA-binding transcription factor activity
C1C92_RS17780	COG0243	molybdopterin cofactor binding
C1C92_RS17785	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C1C92_RS17800	COG0583	DNA-binding transcription factor activity
C1C92_RS17805	COG1879	ABC-type sugar transport system periplasmic component
C1C92_RS17810	COG1129	ABC transporter
C1C92_RS17815	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1C92_RS17820	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1C92_RS17835	COG0702	epimerase
C1C92_RS17840	COG1073	alpha beta
C1C92_RS17845	COG1073	alpha beta
C1C92_RS17885	COG0730	response to heat
C1C92_RS17895	COG1028	Short-chain dehydrogenase reductase Sdr
C1C92_RS17905	COG1024	Enoyl-CoA hydratase
C1C92_RS17910	COG1024	Enoyl-CoA hydratase
C1C92_RS17915	COG1960	acyl-CoA dehydrogenase activity
C1C92_RS17925	COG1960	acyl-CoA dehydrogenase activity
C1C92_RS17930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1C92_RS17935	COG1024	Enoyl-CoA hydratase
C1C92_RS17960	COG1584	GPR1 FUN34 yaaH family protein
C1C92_RS17965	COG3228	Belongs to the MtfA family
C1C92_RS17975	COG1115	amino acid carrier protein
C1C92_RS17980	COG1024	Enoyl-CoA hydratase
C1C92_RS17995	COG3162	membrane
C1C92_RS18000	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1C92_RS18005	COG0488	(ABC) transporter
C1C92_RS18010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1C92_RS18015	COG0776	regulation of translation
C1C92_RS18020	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1C92_RS18025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C1C92_RS18030	COG0740	serine-type endopeptidase activity
C1C92_RS18035	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1C92_RS18050	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C1C92_RS18055	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1C92_RS18060	COG1136	(ABC) transporter
C1C92_RS18065	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1C92_RS18075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C1C92_RS18080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C1C92_RS18100	COG2062	phosphohistidine phosphatase, SixA
C1C92_RS18110	COG0500	methyltransferase
C1C92_RS18120	COG1846	Transcriptional regulator
C1C92_RS18195	COG0789	Transcriptional regulator
C1C92_RS18280	COG0582	viral genome integration into host DNA
C1C92_RS18290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1C92_RS18290	COG0519	Catalyzes the synthesis of GMP from XMP
C1C92_RS18295	COG0516	GMP reductase activity
C1C92_RS18295	COG0517	IMP dehydrogenase activity
C1C92_RS18305	COG1874	Beta-galactosidase
C1C92_RS18305	COG0366	Alpha amylase catalytic
C1C92_RS18315	COG1570	exodeoxyribonuclease VII activity
C1C92_RS18325	COG2885	chlorophyll binding
C1C92_RS18345	COG2154	pterin-4-alpha-carbinolamine dehydratase
C1C92_RS18355	COG3768	UPF0283 membrane protein
C1C92_RS18360	COG3106	COG3106 Predicted ATPase
C1C92_RS18375	COG1842	Phage shock protein A
C1C92_RS18380	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C1C92_RS18395	COG4171	peptide transport system, permease
C1C92_RS18405	COG4172	Belongs to the ABC transporter superfamily
C1C92_RS18415	COG1609	Transcriptional regulator
C1C92_RS18420	COG1263	PTS System
C1C92_RS18420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1C92_RS18425	COG2723	6-phospho-beta-galactosidase activity
C1C92_RS18430	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C1C92_RS18435	COG1286	toxin biosynthetic process
C1C92_RS18440	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1C92_RS18450	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C1C92_RS18455	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C1C92_RS18460	COG1674	ftsk spoiiie
C1C92_RS18460	COG0531	amino acid
C1C92_RS18470	COG0686	Belongs to the AlaDH PNT family
C1C92_RS18475	COG0492	ferredoxin-NADP+ reductase activity
C1C92_RS18480	COG3706	GGDEF domain
C1C92_RS18485	COG3134	Outer membrane lipoprotein
C1C92_RS18490	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C1C92_RS18495	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C1C92_RS18500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1C92_RS18505	COG0542	response to heat
C1C92_RS18510	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C1C92_RS18515	COG1278	Cold shock
C1C92_RS18520	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1C92_RS18535	COG1944	ATP diphosphatase activity
C1C92_RS18540	COG2116	formate transmembrane transporter activity
C1C92_RS18545	COG1882	Formate acetyltransferase
C1C92_RS18550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1C92_RS18555	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1C92_RS18560	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1C92_RS18570	COG1840	ABC-type Fe3 transport system, periplasmic component
C1C92_RS18575	COG3842	ATPase activity
C1C92_RS18585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1C92_RS18590	COG2983	Belongs to the UPF0260 family
C1C92_RS18600	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C1C92_RS18605	COG0045	succinate-CoA ligase (ADP-forming) activity
C1C92_RS18610	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1C92_RS18615	COG0567	Dehydrogenase, E1 component
C1C92_RS18630	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C1C92_RS18635	COG2009	succinate dehydrogenase
C1C92_RS18655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1C92_RS18660	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C1C92_RS18660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1C92_RS18670	COG3069	C4-dicarboxylate transmembrane transporter activity
C1C92_RS18685	COG1451	nucleotide metabolic process
C1C92_RS18700	COG0254	rRNA binding
C1C92_RS18705	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1C92_RS18715	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1C92_RS18720	COG1129	ABC transporter
C1C92_RS18725	COG1879	ABC-type sugar transport system periplasmic component
C1C92_RS18730	COG1069	ribulokinase activity
C1C92_RS18740	COG2160	L-arabinose isomerase activity
C1C92_RS18745	COG0583	DNA-binding transcription factor activity
C1C92_RS18750	COG0436	Aminotransferase
C1C92_RS18755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1C92_RS18770	COG0392	lysyltransferase activity
C1C92_RS18770	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C1C92_RS18805	COG1263	PTS System
C1C92_RS18805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1C92_RS18810	COG1874	Beta-galactosidase
C1C92_RS18815	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C1C92_RS18820	COG3833	ABC-type maltose transport systems, permease component
C1C92_RS18825	COG1175	transmembrane transport
C1C92_RS18830	COG2182	Extracellular solute-binding protein
C1C92_RS18855	COG4580	involved in the transport of maltose and maltodextrins
C1C92_RS18865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1C92_RS18870	COG1085	galactose-1-phosphate uridylyltransferase
C1C92_RS18875	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C1C92_RS18895	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C1C92_RS18930	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C1C92_RS18950	COG2925	Exonuclease
C1C92_RS18960	COG3345	alpha-galactosidase
C1C92_RS18965	COG1380	Effector of murein hydrolase LrgA
C1C92_RS18970	COG1346	cytolysis
C1C92_RS18975	COG0295	cytidine deaminase activity
C1C92_RS18980	COG1022	Amp-dependent synthetase and ligase
C1C92_RS18995	COG0861	Integral membrane protein TerC family
C1C92_RS19000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1C92_RS19005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C1C92_RS19010	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C1C92_RS19050	COG4771	TonB-dependent receptor
C1C92_RS19055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1C92_RS19060	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1C92_RS19065	COG1120	ATPase activity
C1C92_RS19080	COG3321	synthase
C1C92_RS19080	COG0318	PFAM AMP-dependent synthetase and ligase
C1C92_RS19080	COG0300	oxidoreductase activity
C1C92_RS19080	COG1028	Short-chain dehydrogenase reductase Sdr
C1C92_RS19080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1C92_RS19090	COG1028	Short-chain dehydrogenase reductase Sdr
C1C92_RS19095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1C92_RS19100	COG3433	isochorismatase activity
C1C92_RS19100	COG1535	isochorismatase
C1C92_RS19105	COG1021	2,3-dihydroxybenzoate-AMP ligase
C1C92_RS19130	COG5001	Diguanylate cyclase
C1C92_RS19130	COG3300	MHYT domain
C1C92_RS19145	COG0840	transmembrane signaling receptor activity
C1C92_RS19150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1C92_RS19155	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C1C92_RS19160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C1C92_RS19165	COG0563	adenylate kinase activity
C1C92_RS19170	COG0326	Molecular chaperone. Has ATPase activity
C1C92_RS19180	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C1C92_RS19185	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C1C92_RS19190	COG0298	carbon dioxide binding
C1C92_RS19200	COG0309	Hydrogenase expression formation protein (HypE)
C1C92_RS19205	COG0375	protein maturation
C1C92_RS19210	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C1C92_RS19215	COG1124	(ABC) transporter
C1C92_RS19225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1C92_RS19240	COG1773	rubredoxin
C1C92_RS19245	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C1C92_RS19250	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C1C92_RS19255	COG5557	Pfam Polysulphide reductase, NrfD
C1C92_RS19260	COG0437	4 iron, 4 sulfur cluster binding
C1C92_RS19265	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C1C92_RS19270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1C92_RS19280	COG0659	secondary active sulfate transmembrane transporter activity
C1C92_RS19300	COG2308	Evidence 4 Homologs of previously reported genes of
C1C92_RS19335	COG0672	)-iron permease
C1C92_RS19360	COG2814	Major facilitator Superfamily
C1C92_RS19380	COG1136	(ABC) transporter
C1C92_RS19385	COG0577	efflux transmembrane transporter activity
C1C92_RS19410	COG1139	Iron-sulfur cluster binding protein
C1C92_RS19415	COG0247	lactate metabolic process
C1C92_RS19420	COG1620	l-lactate permease
C1C92_RS19425	COG0583	DNA-binding transcription factor activity
C1C92_RS19450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1C92_RS19455	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C1C92_RS19455	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1C92_RS19460	COG0527	aspartate kinase activity
C1C92_RS19470	COG1368	sulfuric ester hydrolase activity
C1C92_RS19475	COG0393	Putative heavy-metal-binding
C1C92_RS19485	COG1252	NADH dehydrogenase
C1C92_RS19490	COG3150	esterase
C1C92_RS19495	COG1164	Oligoendopeptidase f
C1C92_RS19500	COG1164	Oligoendopeptidase f
C1C92_RS19520	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1C92_RS19525	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1C92_RS19560	COG0537	adenosine 5'-monophosphoramidase activity
C1C92_RS19575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1C92_RS19595	COG1301	dicarboxylic acid transport
C1C92_RS19605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1C92_RS19610	COG0861	Integral membrane protein TerC family
C1C92_RS19620	COG0444	Belongs to the ABC transporter superfamily
C1C92_RS19625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1C92_RS19630	COG0601	transmembrane transport
C1C92_RS19640	COG2095	MarC family integral membrane protein
C1C92_RS19645	COG1012	belongs to the aldehyde dehydrogenase family
C1C92_RS19645	COG1454	alcohol dehydrogenase
C1C92_RS19660	COG3279	Response regulator of the LytR AlgR family
C1C92_RS19665	COG1966	Carbon starvation protein
C1C92_RS19670	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C1C92_RS19670	COG3264	Mechanosensitive ion channel
C1C92_RS19680	COG1566	PFAM secretion protein HlyD family protein
C1C92_RS19685	COG1061	Type III restriction enzyme res subunit
C1C92_RS19695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C1C92_RS19705	COG0436	Aminotransferase
C1C92_RS19710	COG1288	antiporter activity
C1C92_RS19715	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1C92_RS19730	COG0697	spore germination
C1C92_RS19735	COG4657	Part of a membrane complex involved in electron transport
C1C92_RS19740	COG2878	Part of a membrane complex involved in electron transport
C1C92_RS19750	COG4658	electron transport chain
C1C92_RS19755	COG4659	FMN binding
C1C92_RS19760	COG4660	Part of a membrane complex involved in electron transport
C1C92_RS19765	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C1C92_RS19770	COG0346	lactoylglutathione lyase activity
C1C92_RS19795	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1C92_RS19805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1C92_RS19810	COG1086	Polysaccharide biosynthesis protein
C1C92_RS19815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1C92_RS19825	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
C1C92_RS19830	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C1C92_RS19845	COG2089	acid synthase
C1C92_RS19885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1C92_RS19905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1C92_RS19905	COG0301	tRNA thio-modification
C1C92_RS19915	COG4953	penicillin-binding protein 1C
C1C92_RS19920	COG2373	Large extracellular alpha-helical protein
C1C92_RS19935	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1C92_RS19945	COG4160	amino acid transport
C1C92_RS19955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C92_RS19965	COG2431	L-lysine efflux transmembrane transporter activity
C1C92_RS19970	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1C92_RS19975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1C92_RS20000	COG1393	Belongs to the ArsC family
C1C92_RS20010	COG4783	chaperone-mediated protein folding
C1C92_RS20015	COG0425	Belongs to the sulfur carrier protein TusA family
C1C92_RS20030	COG0596	Alpha beta hydrolase
C1C92_RS20040	COG3842	ATPase activity
C1C92_RS20045	COG3833	ABC-type maltose transport systems, permease component
C1C92_RS20050	COG1175	transmembrane transport
C1C92_RS20060	COG3081	Nucleoid-associated protein
C1C92_RS20065	COG3082	Protein of unknown function (DUF1414)
C1C92_RS20070	COG3083	sulfuric ester hydrolase activity
C1C92_RS20075	COG4771	TonB-dependent receptor
C1C92_RS20080	COG1770	oligopeptidase
C1C92_RS20100	COG4574	serine-type endopeptidase inhibitor activity
C1C92_RS20105	COG3085	chromosome segregation
C1C92_RS20115	COG1605	Chorismate mutase
C1C92_RS20115	COG0287	Prephenate dehydrogenase
C1C92_RS20120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1C92_RS20125	COG0584	glycerophosphoryl diester phosphodiesterase
C1C92_RS20135	COG1349	DNA-binding transcription factor activity
C1C92_RS20140	COG2271	Major facilitator Superfamily
C1C92_RS20145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1C92_RS20150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C1C92_RS20155	COG0583	DNA-binding transcription factor activity
C1C92_RS20175	COG0656	L-ascorbic acid biosynthetic process
C1C92_RS20180	COG2814	Major facilitator Superfamily
C1C92_RS20200	COG1294	oxidase, subunit
C1C92_RS20210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1C92_RS20220	COG2979	Protein of unknown function (DUF533)
C1C92_RS20240	COG0583	DNA-binding transcription factor activity
C1C92_RS20250	COG2807	transmembrane transport
C1C92_RS20255	COG1187	pseudouridine synthase activity
C1C92_RS20260	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C1C92_RS20280	COG1061	Type III restriction enzyme res subunit
C1C92_RS20305	COG1166	arginine decarboxylase activity
C1C92_RS20320	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1C92_RS20335	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C1C92_RS20350	COG0583	DNA-binding transcription factor activity
C1C92_RS20360	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C1C92_RS20365	COG0840	transmembrane signaling receptor activity
C1C92_RS20370	COG0302	gtp cyclohydrolase
C1C92_RS20380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1C92_RS20395	COG2267	carboxylic ester hydrolase activity
C1C92_RS20400	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C1C92_RS20415	COG0314	molybdopterin synthase activity
C1C92_RS20420	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C1C92_RS20425	COG0315	cyclic pyranopterin monophosphate synthase activity
C1C92_RS20430	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1C92_RS20435	COG3005	denitrification pathway
C1C92_RS20445	COG0348	domain, Protein
C1C92_RS20450	COG0437	4 iron, 4 sulfur cluster binding
C1C92_RS20455	COG0243	molybdopterin cofactor binding
C1C92_RS20465	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1C92_RS20465	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1C92_RS20470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C1C92_RS20475	COG3850	Histidine kinase
C1C92_RS20480	COG2197	response regulator
C1C92_RS20505	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C1C92_RS20515	COG0121	glutamine amidotransferase
C1C92_RS20520	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1C92_RS20525	COG1960	acyl-CoA dehydrogenase activity
C1C92_RS20530	COG3437	response regulator, receiver
C1C92_RS20530	COG0784	Response regulator, receiver
C1C92_RS20540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1C92_RS20545	COG0328	RNA-DNA hybrid ribonuclease activity
C1C92_RS20550	COG2226	methyltransferase
C1C92_RS20555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1C92_RS20560	COG0741	lytic transglycosylase activity
C1C92_RS20560	COG1388	LysM domain
C1C92_RS20575	COG1607	acyl-coa hydrolase
C1C92_RS20590	COG0741	lytic transglycosylase activity
C1C92_RS20600	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1C92_RS20625	COG2911	Protein conserved in bacteria
C1C92_RS20630	COG0729	surface antigen
C1C92_RS20640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1C92_RS20650	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1C92_RS20660	COG4134	Bacterial extracellular solute-binding protein
C1C92_RS20675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C1C92_RS20680	COG2951	lytic endotransglycosylase activity
C1C92_RS20685	COG1846	Transcriptional regulator
C1C92_RS20695	COG0033	Phosphoglucomutase
C1C92_RS20700	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C1C92_RS20720	COG0716	FMN binding
C1C92_RS20730	COG0735	belongs to the Fur family
C1C92_RS20735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1C92_RS20745	COG2190	(PTS) system
C1C92_RS20745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1C92_RS20745	COG1263	PTS System
C1C92_RS20750	COG0363	glucosamine-6-phosphate deaminase activity
C1C92_RS20755	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1C92_RS20760	COG1940	carbohydrate kinase activity
C1C92_RS20760	COG1846	Transcriptional regulator
C1C92_RS20765	COG2194	sulfuric ester hydrolase activity
C1C92_RS20770	COG0217	transcriptional regulatory protein
C1C92_RS20775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C1C92_RS20785	COG1801	Protein of unknown function DUF72
C1C92_RS20790	COG4106	trans-aconitate 2-methyltransferase activity
C1C92_RS20795	COG0500	methyltransferase
C1C92_RS20815	COG0583	DNA-binding transcription factor activity
C1C92_RS20820	COG0791	NLP P60 protein
C1C92_RS20835	COG1309	transcriptional regulator
C1C92_RS20845	COG1454	alcohol dehydrogenase
C1C92_RS20870	COG0534	Mate efflux family protein
C1C92_RS20880	COG2841	Protein conserved in bacteria
C1C92_RS20890	COG1013	pyruvate-flavodoxin oxidoreductase activity
C1C92_RS20890	COG0674	pyruvate-flavodoxin oxidoreductase activity
C1C92_RS20890	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C1C92_RS20890	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C1C92_RS20900	COG3217	Mosc domain protein beta barrel domain protein
C1C92_RS20900	COG0633	Ferredoxin
C1C92_RS20900	COG3217	Mosc domain protein beta barrel domain protein
C1C92_RS20900	COG0633	Ferredoxin
C1C92_RS20905	COG0501	Belongs to the peptidase M48B family
C1C92_RS20910	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C1C92_RS20915	COG1073	alpha beta
C1C92_RS20915	COG2226	methyltransferase
C1C92_RS20920	COG0156	8-amino-7-oxononanoate synthase activity
C1C92_RS20925	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C1C92_RS20945	COG0017	Asparaginyl-tRNA synthetase
C1C92_RS20950	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C1C92_RS20965	COG3069	C4-dicarboxylate transmembrane transporter activity
C1C92_RS20975	COG1393	Belongs to the ArsC family
C1C92_RS20980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1C92_RS20985	COG1876	peptidase activity
C1C92_RS20995	COG3263	regulation of cellular component size
C1C92_RS21005	COG1280	lysine exporter protein (LysE YggA)
C1C92_RS21035	COG1957	nucleoside hydrolase
C1C92_RS21040	COG0564	pseudouridine synthase activity
C1C92_RS21050	COG1454	alcohol dehydrogenase
C1C92_RS21055	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1C92_RS21060	COG0702	epimerase
C1C92_RS21065	COG2914	Belongs to the UPF0125 (RnfH) family
C1C92_RS21070	COG2867	negative regulation of translational initiation
C1C92_RS21075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C1C92_RS21320	COG0305	Participates in initiation and elongation during chromosome replication
C1C92_RS21385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1C92_RS21415	COG2974	May be involved in recombination
C1C92_RS21455	COG0582	viral genome integration into host DNA
C1C92_RS21460	COG0582	viral genome integration into host DNA
C1C92_RS21465	COG2916	Histone family protein nucleoid-structuring protein H-NS
C1C92_RS21525	COG1596	polysaccharide export
C1C92_RS21585	COG3039	Transposase
C1C92_RS21595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1C92_RS21635	COG2916	Histone family protein nucleoid-structuring protein H-NS
C1C92_RS21645	COG4983	Phage plasmid primase, P4 family domain protein
C1C92_RS21665	COG5377	YqaJ viral recombinase family
C1C92_RS21700	COG2003	Belongs to the UPF0758 family
C1C92_RS21765	COG1715	Restriction endonuclease
C1C92_RS21775	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C1C92_RS21785	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1C92_RS21790	COG0210	DNA helicase
C1C92_RS21825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1C92_RS21835	COG0800	Aldolase
C1C92_RS21850	COG3153	acetyltransferase
C1C92_RS21880	COG0259	pyridoxamine-phosphate oxidase activity
C1C92_RS21895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1C92_RS21895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1C92_RS21900	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C1C92_RS21925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1C92_RS21930	COG1138	Cytochrome C-type biogenesis protein
C1C92_RS21935	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C1C92_RS21940	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1C92_RS21945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1C92_RS21950	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1C92_RS21965	COG0835	chemotaxis
C1C92_RS21975	COG1192	Involved in chromosome partitioning
C1C92_RS21980	COG1360	Flagellar Motor Protein
C1C92_RS21985	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1C92_RS21990	COG2201	protein-glutamate methylesterase activity
C1C92_RS21995	COG0643	Histidine kinase
C1C92_RS21995	COG0784	Response regulator, receiver
C1C92_RS21995	COG2198	Histidine kinase
C1C92_RS22000	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C1C92_RS22025	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1C92_RS22035	COG1684	flagellar biosynthetic protein fliR
C1C92_RS22105	COG1677	Flagellar hook-basal body complex protein FliE