locus-tag	class	description
H7R78_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7R78_RS00010	COG0592	DNA-directed DNA polymerase activity
H7R78_RS00020	COG0187	DNA topoisomerase II activity
H7R78_RS00030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7R78_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
H7R78_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
H7R78_RS00045	COG3977	Valine--pyruvate aminotransferase
H7R78_RS00060	COG2814	Major facilitator Superfamily
H7R78_RS00065	COG0745	RESPONSE REGULATOR receiver
H7R78_RS00070	COG2205	protein histidine kinase activity
H7R78_RS00115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7R78_RS00120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R78_RS00120	COG4191	Histidine kinase
H7R78_RS00125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R78_RS00130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R78_RS00135	COG1309	transcriptional regulator
H7R78_RS00165	COG0561	phosphatase activity
H7R78_RS00170	COG2267	carboxylic ester hydrolase activity
H7R78_RS00180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7R78_RS00185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7R78_RS00190	COG1758	RNA polymerase activity
H7R78_RS00200	COG0859	PFAM glycosyl transferase family 9
H7R78_RS00205	COG3642	lipopolysaccharide core region biosynthetic process
H7R78_RS00245	COG0589	response to stress
H7R78_RS00250	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7R78_RS00255	COG3706	GGDEF domain
H7R78_RS00260	COG1528	Iron-storage protein
H7R78_RS00265	COG2081	HI0933 family
H7R78_RS00270	COG2223	nitrite transmembrane transporter activity
H7R78_RS00275	COG1280	lysine exporter protein (LysE YggA)
H7R78_RS00290	COG5433	transposase activity
H7R78_RS00300	COG3188	usher protein
H7R78_RS00320	COG2205	protein histidine kinase activity
H7R78_RS00320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R78_RS00330	COG3275	phosphorelay sensor kinase activity
H7R78_RS00335	COG3279	Response regulator of the LytR AlgR family
H7R78_RS00340	COG2223	nitrite transmembrane transporter activity
H7R78_RS00345	COG3385	transposase activity
H7R78_RS00350	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H7R78_RS00355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H7R78_RS00405	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H7R78_RS00410	COG2166	iron-sulfur cluster assembly
H7R78_RS00415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7R78_RS00435	COG1063	alcohol dehydrogenase
H7R78_RS00450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7R78_RS00465	COG3306	glycosyltransferase involved in LPS biosynthesis
H7R78_RS00470	COG0859	PFAM glycosyl transferase family 9
H7R78_RS00495	COG1609	Transcriptional regulator
H7R78_RS00510	COG1580	Controls the rotational direction of flagella during chemotaxis
H7R78_RS00515	COG3161	chorismate lyase activity
H7R78_RS00520	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H7R78_RS00525	COG2937	Belongs to the GPAT DAPAT family
H7R78_RS00530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7R78_RS00545	COG0534	Mate efflux family protein
H7R78_RS00550	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H7R78_RS00555	COG2205	protein histidine kinase activity
H7R78_RS00560	COG0745	RESPONSE REGULATOR receiver
H7R78_RS00570	COG1045	serine acetyltransferase
H7R78_RS00580	COG3074	FtsZ-dependent cytokinesis
H7R78_RS00585	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H7R78_RS00590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7R78_RS00590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7R78_RS00595	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H7R78_RS00630	COG1609	Transcriptional regulator
H7R78_RS00635	COG3250	beta-galactosidase activity
H7R78_RS00640	COG2731	YhcH YjgK YiaL family protein
H7R78_RS00645	COG0531	amino acid
H7R78_RS00650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R78_RS00655	COG0531	amino acid
H7R78_RS00660	COG0385	Bile acid
H7R78_RS00665	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7R78_RS00690	COG0583	DNA-binding transcription factor activity
H7R78_RS00695	COG1079	Belongs to the binding-protein-dependent transport system permease family
H7R78_RS00700	COG4603	Belongs to the binding-protein-dependent transport system permease family
H7R78_RS00705	COG3845	ABC transporter
H7R78_RS00710	COG1744	ABC transporter substrate-binding protein PnrA-like
H7R78_RS00725	COG0210	DNA helicase
H7R78_RS00745	COG1943	Transposase
H7R78_RS00750	COG0583	DNA-binding transcription factor activity
H7R78_RS00790	COG1280	lysine exporter protein (LysE YggA)
H7R78_RS00800	COG2962	Rard protein
H7R78_RS00810	COG1012	belongs to the aldehyde dehydrogenase family
H7R78_RS00815	COG1396	sequence-specific DNA binding
H7R78_RS00820	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7R78_RS00830	COG0519	Catalyzes the synthesis of GMP from XMP
H7R78_RS00830	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7R78_RS00840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R78_RS00860	COG1322	Protein conserved in bacteria
H7R78_RS00865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7R78_RS00870	COG0569	domain protein
H7R78_RS00875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7R78_RS00875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7R78_RS00880	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7R78_RS00885	COG0242	peptide deformylase activity
H7R78_RS00895	COG0758	DNA mediated transformation
H7R78_RS00900	COG2922	Belongs to the Smg family
H7R78_RS00905	COG0551	DNA topoisomerase type I activity
H7R78_RS00910	COG0009	L-threonylcarbamoyladenylate synthase
H7R78_RS00915	COG0408	coproporphyrinogen oxidase activity
H7R78_RS00920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7R78_RS00925	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7R78_RS00940	COG3078	GTPase activator activity
H7R78_RS00955	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H7R78_RS00965	COG3852	Histidine kinase
H7R78_RS00975	COG0174	glutamine synthetase
H7R78_RS00980	COG1217	gtp-binding protein TYPA
H7R78_RS00985	COG1295	ribonuclease BN
H7R78_RS00990	COG1490	D-aminoacyl-tRNA deacylase activity
H7R78_RS01000	COG0456	acetyltransferase
H7R78_RS01010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7R78_RS01015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7R78_RS01020	COG2610	gluconate transmembrane transporter activity
H7R78_RS01025	COG3265	gluconokinase activity
H7R78_RS01030	COG0129	dihydroxy-acid dehydratase activity
H7R78_RS01035	COG0800	Aldolase
H7R78_RS01050	COG1609	Transcriptional regulator
H7R78_RS01060	COG4942	peptidase
H7R78_RS01065	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H7R78_RS01070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7R78_RS01075	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H7R78_RS01080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7R78_RS01085	COG0316	Belongs to the HesB IscA family
H7R78_RS01085	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H7R78_RS01090	COG1040	competence protein
H7R78_RS01095	COG0596	Alpha beta hydrolase
H7R78_RS01110	COG2183	response to ionizing radiation
H7R78_RS01115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7R78_RS01125	COG2205	protein histidine kinase activity
H7R78_RS01135	COG0051	transcription antitermination factor activity, RNA binding
H7R78_RS01140	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H7R78_RS01145	COG0088	Forms part of the polypeptide exit tunnel
H7R78_RS01150	COG0089	rRNA binding
H7R78_RS01155	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H7R78_RS01160	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H7R78_RS01165	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H7R78_RS01170	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H7R78_RS01175	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H7R78_RS01180	COG0255	Belongs to the universal ribosomal protein uL29 family
H7R78_RS01185	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H7R78_RS01190	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H7R78_RS01195	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H7R78_RS01200	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H7R78_RS01205	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H7R78_RS01210	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H7R78_RS01215	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H7R78_RS01220	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H7R78_RS01225	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H7R78_RS01230	COG1841	ribosomal large subunit assembly
H7R78_RS01235	COG0200	Binds to the 23S rRNA
H7R78_RS01240	COG0201	protein transport
H7R78_RS01245	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7R78_RS01250	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H7R78_RS01255	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H7R78_RS01260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7R78_RS01265	COG0202	RNA polymerase activity
H7R78_RS01270	COG0203	ribosomal protein L17
H7R78_RS01310	COG4584	PFAM Integrase catalytic
H7R78_RS01315	COG1484	DNA-dependent DNA replication
H7R78_RS01335	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7R78_RS01340	COG0583	DNA-binding transcription factor activity
H7R78_RS01345	COG4221	oxidoreductase activity
H7R78_RS01360	COG1770	oligopeptidase
H7R78_RS01365	COG2358	TRAP transporter, solute receptor (TAXI family
H7R78_RS01375	COG3385	transposase activity
H7R78_RS01385	COG3714	YhhN family
H7R78_RS01400	COG0583	DNA-binding transcription factor activity
H7R78_RS01410	COG1301	dicarboxylic acid transport
H7R78_RS01420	COG2095	MarC family integral membrane protein
H7R78_RS01430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7R78_RS01440	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7R78_RS01450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7R78_RS01475	COG0742	ribosomal rna small subunit methyltransferase
H7R78_RS01480	COG0552	protein localization to endoplasmic reticulum
H7R78_RS01485	COG2884	Cell division ATP-binding protein ftsE
H7R78_RS01490	COG2177	Part of the ABC transporter FtsEX involved in
H7R78_RS01500	COG0288	reversible hydration of carbon dioxide
H7R78_RS01505	COG2188	Transcriptional regulator
H7R78_RS01510	COG1228	amidohydrolase
H7R78_RS01515	COG0010	Belongs to the arginase family
H7R78_RS01520	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H7R78_RS01525	COG2986	histidine ammonia-lyase
H7R78_RS01535	COG0387	Pfam Sodium calcium exchanger
H7R78_RS01595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7R78_RS01600	COG1459	type II secretion system
H7R78_RS01645	COG1077	Cell shape determining protein MreB Mrl
H7R78_RS01650	COG1792	Involved in formation and maintenance of cell shape
H7R78_RS01655	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H7R78_RS01660	COG0424	maF-like protein
H7R78_RS01665	COG1530	ribonuclease E activity
H7R78_RS01670	COG3164	Protein of unknown function
H7R78_RS01675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7R78_RS01680	COG0312	modulator of DNA gyrase
H7R78_RS01700	COG0477	Major facilitator Superfamily
H7R78_RS01710	COG2321	neutral zinc metallopeptidase
H7R78_RS01765	COG0582	viral genome integration into host DNA
H7R78_RS01790	COG0189	ligase activity
H7R78_RS01795	COG0642	Histidine kinase
H7R78_RS01800	COG0745	RESPONSE REGULATOR receiver
H7R78_RS01815	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H7R78_RS01820	COG0352	thiamine-phosphate diphosphorylase activity
H7R78_RS01825	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7R78_RS01835	COG2022	thiamine diphosphate biosynthetic process
H7R78_RS01840	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7R78_RS01860	COG3932	Exopolysaccharide synthesis, ExoD
H7R78_RS01875	COG1733	regulation of RNA biosynthetic process
H7R78_RS01900	COG2226	methyltransferase
H7R78_RS01910	COG1494	fructose-1,6-bisphosphatase
H7R78_RS01920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7R78_RS01925	COG5007	Belongs to the BolA IbaG family
H7R78_RS01935	COG2854	intermembrane phospholipid transfer
H7R78_RS01940	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7R78_RS01945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7R78_RS01950	COG1127	ABC transporter
H7R78_RS01955	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H7R78_RS01955	COG0517	IMP dehydrogenase activity
H7R78_RS01960	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H7R78_RS01970	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H7R78_RS01975	COG1137	ATPase activity
H7R78_RS01980	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H7R78_RS01990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R78_RS01995	COG1660	Displays ATPase and GTPase activities
H7R78_RS02000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R78_RS02020	COG3964	amidohydrolase
H7R78_RS02050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7R78_RS02055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7R78_RS02065	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H7R78_RS02070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7R78_RS02075	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H7R78_RS02080	COG0723	plastoquinol--plastocyanin reductase activity
H7R78_RS02085	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7R78_RS02090	COG2857	Cytochrome c1
H7R78_RS02095	COG0625	glutathione transferase activity
H7R78_RS02100	COG2969	positive regulation of protein catabolic process
H7R78_RS02105	COG2823	Periplasmic or secreted lipoprotein
H7R78_RS02110	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7R78_RS02115	COG0792	nuclease activity
H7R78_RS02120	COG3107	peptidoglycan biosynthetic process
H7R78_RS02125	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H7R78_RS02135	COG2001	Belongs to the MraZ family
H7R78_RS02140	COG0275	rRNA processing
H7R78_RS02145	COG3116	cell division
H7R78_RS02150	COG0768	penicillin binding
H7R78_RS02155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7R78_RS02160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7R78_RS02165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7R78_RS02170	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7R78_RS02175	COG0772	Belongs to the SEDS family
H7R78_RS02180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7R78_RS02185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7R78_RS02190	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H7R78_RS02195	COG0849	cell division
H7R78_RS02200	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7R78_RS02205	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H7R78_RS02215	COG0653	protein targeting
H7R78_RS02225	COG0494	nUDIX hydrolase
H7R78_RS02230	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H7R78_RS02235	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H7R78_RS02245	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H7R78_RS02250	COG1459	type II secretion system
H7R78_RS02255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7R78_RS02285	COG2186	Transcriptional regulator
H7R78_RS02290	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H7R78_RS02295	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7R78_RS02300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7R78_RS02310	COG0840	transmembrane signaling receptor activity
H7R78_RS02315	COG0840	transmembrane signaling receptor activity
H7R78_RS02320	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7R78_RS02325	COG1049	propionate catabolic process, 2-methylcitrate cycle
H7R78_RS02330	COG2200	EAL domain
H7R78_RS02340	COG1280	lysine exporter protein (LysE YggA)
H7R78_RS02350	COG0523	cobalamin synthesis protein
H7R78_RS02355	COG0477	Major facilitator Superfamily
H7R78_RS02370	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H7R78_RS02375	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H7R78_RS02420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H7R78_RS02430	COG1546	Belongs to the CinA family
H7R78_RS02435	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7R78_RS02440	COG2137	regulation of response to DNA damage stimulus
H7R78_RS02450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7R78_RS02455	COG0527	aspartate kinase activity
H7R78_RS02460	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H7R78_RS02495	COG1686	Belongs to the peptidase S11 family
H7R78_RS02500	COG0586	Pfam SNARE associated Golgi protein
H7R78_RS02505	COG1253	flavin adenine dinucleotide binding
H7R78_RS02510	COG0525	valine-tRNA ligase activity
H7R78_RS02515	COG2927	DNA polymerase III (CHI subunit)
H7R78_RS02520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7R78_RS02525	COG0795	lipopolysaccharide-transporting ATPase activity
H7R78_RS02530	COG0795	lipopolysaccharide-transporting ATPase activity
H7R78_RS02535	COG3385	transposase activity
H7R78_RS02550	COG0582	viral genome integration into host DNA
H7R78_RS02570	COG2801	Transposase and inactivated derivatives
H7R78_RS02585	COG0004	ammonium transporteR
H7R78_RS02590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7R78_RS02600	COG3039	Transposase
H7R78_RS02615	COG0084	hydrolase, TatD family'
H7R78_RS02620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R78_RS02630	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H7R78_RS02635	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H7R78_RS02640	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H7R78_RS02645	COG0813	purine-nucleoside phosphorylase activity
H7R78_RS02650	COG5001	Diguanylate cyclase
H7R78_RS02650	COG3447	MASE1 domain protein
H7R78_RS02650	COG5002	protein histidine kinase activity
H7R78_RS02660	COG0560	Phosphoserine phosphatase
H7R78_RS02675	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H7R78_RS02685	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
H7R78_RS02690	COG0776	regulation of translation
H7R78_RS02705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7R78_RS02710	COG0735	belongs to the Fur family
H7R78_RS02730	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H7R78_RS02735	COG0513	Belongs to the DEAD box helicase family
H7R78_RS02740	COG3022	response to hydroperoxide
H7R78_RS02755	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H7R78_RS02760	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7R78_RS02765	COG0762	integral membrane protein
H7R78_RS02770	COG1872	DUF167
H7R78_RS02790	COG3112	Uncharacterised protein family (UPF0231)
H7R78_RS02795	COG3835	regulator
H7R78_RS02800	COG2610	gluconate transmembrane transporter activity
H7R78_RS02805	COG1929	Belongs to the glycerate kinase type-1 family
H7R78_RS02820	COG0583	DNA-binding transcription factor activity
H7R78_RS02825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R78_RS02840	COG0347	Belongs to the P(II) protein family
H7R78_RS02845	COG1840	ABC-type Fe3 transport system, periplasmic component
H7R78_RS02855	COG3842	ATPase activity
H7R78_RS02860	COG2837	iron assimilation
H7R78_RS02865	COG1438	arginine binding
H7R78_RS02870	COG1126	abc transporter atp-binding protein
H7R78_RS02875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R78_RS02880	COG4215	(ABC) transporter
H7R78_RS02885	COG4160	amino acid transport
H7R78_RS02890	COG0039	L-malate dehydrogenase activity
H7R78_RS02895	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H7R78_RS02900	COG1017	nitric oxide dioxygenase activity
H7R78_RS02900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R78_RS02910	COG4536	flavin adenine dinucleotide binding
H7R78_RS02915	COG4137	Cytochrome C assembly protein
H7R78_RS02920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7R78_RS02925	COG0228	four-way junction DNA binding
H7R78_RS02930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H7R78_RS02935	COG0336	Belongs to the RNA methyltransferase TrmD family
H7R78_RS02940	COG0335	large ribosomal subunit rRNA binding
H7R78_RS02955	COG1051	belongs to the nudix hydrolase family
H7R78_RS02965	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H7R78_RS02970	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H7R78_RS02975	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7R78_RS02985	COG0583	DNA-binding transcription factor activity
H7R78_RS02990	COG0640	Transcriptional regulator
H7R78_RS02995	COG0268	Binds directly to 16S ribosomal RNA
H7R78_RS03000	COG0728	peptidoglycan biosynthetic process
H7R78_RS03005	COG0196	riboflavin kinase activity
H7R78_RS03010	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H7R78_RS03015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H7R78_RS03020	COG1047	Peptidyl-prolyl cis-trans
H7R78_RS03025	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7R78_RS03065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7R78_RS03065	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7R78_RS03080	COG1854	S-ribosylhomocysteine lyase activity
H7R78_RS03085	COG3385	transposase activity
H7R78_RS03090	COG3706	GGDEF domain
H7R78_RS03095	COG0557	exoribonuclease II activity
H7R78_RS03100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7R78_RS03110	COG2153	protein acetylation
H7R78_RS03120	COG1914	H( )-stimulated, divalent metal cation uptake system
H7R78_RS03125	COG0360	Binds together with S18 to 16S ribosomal RNA
H7R78_RS03130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H7R78_RS03135	COG0359	binds to the 23S rRNA
H7R78_RS03175	COG1238	metal cluster binding
H7R78_RS03180	COG0612	Peptidase, M16
H7R78_RS03185	COG2918	glutathione biosynthetic process
H7R78_RS03190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H7R78_RS03195	COG1027	Aspartate ammonia-lyase
H7R78_RS03200	COG3030	protein affecting phage T7 exclusion by the F plasmid
H7R78_RS03205	COG0534	Mate efflux family protein
H7R78_RS03210	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7R78_RS03215	COG0459	protein refolding
H7R78_RS03235	COG0564	pseudouridine synthase activity
H7R78_RS03240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7R78_RS03270	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H7R78_RS03280	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H7R78_RS03285	COG4208	sulfate ABC transporter
H7R78_RS03290	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H7R78_RS03295	COG0583	DNA-binding transcription factor activity
H7R78_RS03300	COG3397	chitin binding
H7R78_RS03330	COG1328	CTP reductase activity
H7R78_RS03335	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7R78_RS03350	COG1448	Aminotransferase
H7R78_RS03355	COG2194	sulfuric ester hydrolase activity
H7R78_RS03375	COG1215	transferase activity, transferring glycosyl groups
H7R78_RS03380	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H7R78_RS03385	COG3118	belongs to the thioredoxin family
H7R78_RS03385	COG0457	Tetratricopeptide repeat
H7R78_RS03420	COG0513	Belongs to the DEAD box helicase family
H7R78_RS03425	COG0840	transmembrane signaling receptor activity
H7R78_RS03435	COG4166	transmembrane transport
H7R78_RS03450	COG1024	Enoyl-CoA hydratase
H7R78_RS03465	COG4221	oxidoreductase activity
H7R78_RS03470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7R78_RS03475	COG0442	prolyl-tRNA aminoacylation
H7R78_RS03480	COG0840	transmembrane signaling receptor activity
H7R78_RS03485	COG0632	four-way junction helicase activity
H7R78_RS03490	COG2255	four-way junction helicase activity
H7R78_RS03500	COG1271	oxidase subunit
H7R78_RS03505	COG1294	oxidase, subunit
H7R78_RS03510	COG4890	Cyd operon protein YbgT
H7R78_RS03515	COG3790	cyd operon protein YbgE
H7R78_RS03520	COG0824	Thioesterase
H7R78_RS03525	COG0811	peptide transport
H7R78_RS03540	COG0823	Involved in the tonB-independent uptake of proteins
H7R78_RS03545	COG2885	chlorophyll binding
H7R78_RS03550	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H7R78_RS03625	COG0840	transmembrane signaling receptor activity
H7R78_RS03630	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H7R78_RS03640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7R78_RS03645	COG1640	4-alpha-glucanotransferase
H7R78_RS03650	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7R78_RS03680	COG2130	NADP-dependent
H7R78_RS03685	COG1846	Transcriptional regulator
H7R78_RS03715	COG0561	phosphatase activity
H7R78_RS03730	COG0733	neurotransmitter:sodium symporter activity
H7R78_RS03735	COG0733	neurotransmitter:sodium symporter activity
H7R78_RS03750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R78_RS03765	COG1794	racemase activity, acting on amino acids and derivatives
H7R78_RS03775	COG1022	Amp-dependent synthetase and ligase
H7R78_RS03785	COG0456	acetyltransferase
H7R78_RS03800	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H7R78_RS03805	COG5002	protein histidine kinase activity
H7R78_RS03805	COG5001	Diguanylate cyclase
H7R78_RS03815	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H7R78_RS03825	COG0456	acetyltransferase
H7R78_RS03835	COG0456	acetyltransferase
H7R78_RS03840	COG1902	pentaerythritol trinitrate reductase activity
H7R78_RS03850	COG2852	Protein conserved in bacteria
H7R78_RS03860	COG2957	Belongs to the agmatine deiminase family
H7R78_RS03865	COG0154	amidase activity
H7R78_RS03900	COG1917	Cupin 2, conserved barrel domain protein
H7R78_RS03900	COG2207	Transcriptional regulator
H7R78_RS03910	COG0513	Belongs to the DEAD box helicase family
H7R78_RS03915	COG2199	diguanylate cyclase activity
H7R78_RS03915	COG2203	Gaf domain
H7R78_RS03950	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
H7R78_RS03960	COG1136	(ABC) transporter
H7R78_RS03960	COG0577	efflux transmembrane transporter activity
H7R78_RS03965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R78_RS03970	COG0745	RESPONSE REGULATOR receiver
H7R78_RS03975	COG2205	protein histidine kinase activity
H7R78_RS04025	COG1280	lysine exporter protein (LysE YggA)
H7R78_RS04040	COG3311	Transcriptional regulator
H7R78_RS04060	COG3621	Patatin-like phospholipase
H7R78_RS04085	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
H7R78_RS04095	COG5377	YqaJ viral recombinase family
H7R78_RS04125	COG2003	Belongs to the UPF0758 family
H7R78_RS04175	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H7R78_RS04180	COG0732	type I restriction modification DNA specificity domain
H7R78_RS04195	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H7R78_RS04220	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H7R78_RS04235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R78_RS04265	COG0745	RESPONSE REGULATOR receiver
H7R78_RS04270	COG3104	oligopeptide transport
H7R78_RS04275	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7R78_RS04280	COG1555	photosystem II stabilization
H7R78_RS04290	COG2350	Protein conserved in bacteria
H7R78_RS04295	COG2917	probably involved in intracellular septation
H7R78_RS04300	COG0076	glutamate decarboxylase activity
H7R78_RS04305	COG1272	protein, Hemolysin III
H7R78_RS04310	COG0569	domain protein
H7R78_RS04310	COG2985	domain, Protein
H7R78_RS04320	COG0477	Major facilitator Superfamily
H7R78_RS04325	COG0583	DNA-binding transcription factor activity
H7R78_RS04330	COG3227	Zinc metalloprotease (Elastase)
H7R78_RS04335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7R78_RS04340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7R78_RS04350	COG2731	YhcH YjgK YiaL family protein
H7R78_RS04360	COG0668	transmembrane transport
H7R78_RS04370	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7R78_RS04390	COG0789	Transcriptional regulator
H7R78_RS04440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H7R78_RS04450	COG0488	(ABC) transporter
H7R78_RS04455	COG0517	IMP dehydrogenase activity
H7R78_RS04455	COG0516	GMP reductase activity
H7R78_RS04465	COG0835	chemotaxis
H7R78_RS04465	COG0784	Response regulator, receiver
H7R78_RS04475	COG2755	lipolytic protein G-D-S-L family
H7R78_RS04480	COG4181	ATPase activity
H7R78_RS04485	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H7R78_RS04490	COG1090	epimerase
H7R78_RS04495	COG2200	EAL domain
H7R78_RS04500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R78_RS04505	COG2234	aminopeptidase activity
H7R78_RS04505	COG4935	Belongs to the peptidase S8 family
H7R78_RS04510	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H7R78_RS04515	COG3171	Protein conserved in bacteria
H7R78_RS04520	COG2066	Belongs to the glutaminase family
H7R78_RS04525	COG2897	thiosulfate sulfurtransferase activity
H7R78_RS04535	COG1132	(ABC) transporter
H7R78_RS04560	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
H7R78_RS04565	COG3300	MHYT domain
H7R78_RS04565	COG5001	Diguanylate cyclase
H7R78_RS04585	COG4628	conserved protein (DUF2132)
H7R78_RS04590	COG0688	phosphatidylethanolamine metabolic process
H7R78_RS04595	COG1162	GTPase activity
H7R78_RS04600	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H7R78_RS04640	COG1278	Cold shock
H7R78_RS04650	COG0840	transmembrane signaling receptor activity
H7R78_RS04655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7R78_RS04705	COG0848	biopolymer transport protein
H7R78_RS04710	COG0811	peptide transport
H7R78_RS04715	COG0811	peptide transport
H7R78_RS04725	COG4206	TonB-dependent receptor
H7R78_RS04730	COG4174	ABC transporter (Permease)
H7R78_RS04735	COG4239	(ABC) transporter, permease
H7R78_RS04745	COG0444	Belongs to the ABC transporter superfamily
H7R78_RS04750	COG4608	Belongs to the ABC transporter superfamily
H7R78_RS04755	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7R78_RS04760	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H7R78_RS04765	COG1073	alpha beta
H7R78_RS04780	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H7R78_RS04815	COG0243	molybdopterin cofactor binding
H7R78_RS04820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7R78_RS04820	COG1648	precorrin-2 dehydrogenase activity
H7R78_RS04830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7R78_RS04830	COG1116	anion transmembrane transporter activity
H7R78_RS04835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7R78_RS04840	COG1116	anion transmembrane transporter activity
H7R78_RS04845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7R78_RS04845	COG2146	nitrite reductase [NAD(P)H] activity
H7R78_RS04850	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7R78_RS04850	COG2146	nitrite reductase [NAD(P)H] activity
H7R78_RS04855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R78_RS04860	COG2313	pseudouridylate synthase activity
H7R78_RS04865	COG2313	pseudouridylate synthase activity
H7R78_RS04890	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7R78_RS04900	COG2966	Psort location CytoplasmicMembrane, score
H7R78_RS04915	COG4175	Glycine betaine
H7R78_RS04920	COG4176	ABC-type proline glycine betaine transport system permease component
H7R78_RS04925	COG2113	Glycine betaine
H7R78_RS04930	COG0175	sulfate reduction
H7R78_RS04935	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7R78_RS04940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7R78_RS04950	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H7R78_RS04965	COG0786	glutamate:sodium symporter activity
H7R78_RS04970	COG0252	asparaginase activity
H7R78_RS04975	COG3139	Protein of unknown function (DUF1315)
H7R78_RS04995	COG0616	signal peptide processing
H7R78_RS05000	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R78_RS05000	COG1902	pentaerythritol trinitrate reductase activity
H7R78_RS05005	COG0778	Nitroreductase
H7R78_RS05015	COG0110	maltose O-acetyltransferase activity
H7R78_RS05020	COG2264	protein methyltransferase activity
H7R78_RS05025	COG0604	alcohol dehydrogenase
H7R78_RS05030	COG0583	DNA-binding transcription factor activity
H7R78_RS05035	COG1263	PTS System
H7R78_RS05035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R78_RS05035	COG2190	(PTS) system
H7R78_RS05040	COG4145	pantothenate transmembrane transporter activity
H7R78_RS05045	COG3924	membrane
H7R78_RS05050	COG0439	Biotin carboxylase
H7R78_RS05055	COG0511	ligase activity, forming carbon-carbon bonds
H7R78_RS05060	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7R78_RS05065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7R78_RS05080	COG3381	protein complex oligomerization
H7R78_RS05090	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7R78_RS05100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7R78_RS05105	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7R78_RS05105	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7R78_RS05120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H7R78_RS05125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7R78_RS05130	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H7R78_RS05135	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H7R78_RS05140	COG4172	Belongs to the ABC transporter superfamily
H7R78_RS05150	COG0601	transmembrane transport
H7R78_RS05155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7R78_RS05160	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7R78_RS05165	COG0142	geranyltranstransferase activity
H7R78_RS05170	COG1722	exodeoxyribonuclease VII activity
H7R78_RS05175	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7R78_RS05180	COG1360	Flagellar Motor Protein
H7R78_RS05195	COG1534	Rna-binding protein
H7R78_RS05200	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H7R78_RS05210	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H7R78_RS05215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7R78_RS05220	COG0149	triose-phosphate isomerase activity
H7R78_RS05225	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7R78_RS05240	COG0779	Required for maturation of 30S ribosomal subunits
H7R78_RS05245	COG0195	Participates in both transcription termination and antitermination
H7R78_RS05250	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H7R78_RS05255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H7R78_RS05260	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H7R78_RS05265	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H7R78_RS05270	COG1185	polyribonucleotide nucleotidyltransferase activity
H7R78_RS05275	COG2211	Major facilitator Superfamily
H7R78_RS05280	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H7R78_RS05285	COG1422	Protein of unknown function (DUF1090)
H7R78_RS05290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R78_RS05295	COG0826	peptidase U32
H7R78_RS05305	COG3039	Transposase
H7R78_RS05320	COG4372	Transposase
H7R78_RS05325	COG4804	nuclease activity
H7R78_RS05345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7R78_RS05380	COG2194	sulfuric ester hydrolase activity
H7R78_RS05390	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7R78_RS05395	COG5642	Protein of unknown function (DUF2384)
H7R78_RS05410	COG1484	DNA-dependent DNA replication
H7R78_RS05415	COG4584	PFAM Integrase catalytic
H7R78_RS05430	COG5433	transposase activity
H7R78_RS05500	COG0312	modulator of DNA gyrase
H7R78_RS05510	COG0312	modulator of DNA gyrase
H7R78_RS05520	COG4974	Belongs to the 'phage' integrase family
H7R78_RS05525	COG1970	mechanosensitive ion channel activity
H7R78_RS05540	COG0789	Transcriptional regulator
H7R78_RS05555	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R78_RS05565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7R78_RS05570	COG0321	lipoyl(octanoyl) transferase activity
H7R78_RS05575	COG2921	Belongs to the UPF0250 family
H7R78_RS05580	COG1686	Belongs to the peptidase S11 family
H7R78_RS05585	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7R78_RS05590	COG2951	lytic endotransglycosylase activity
H7R78_RS05595	COG0772	Belongs to the SEDS family
H7R78_RS05600	COG0768	penicillin binding
H7R78_RS05605	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H7R78_RS05610	COG0799	negative regulation of ribosome biogenesis
H7R78_RS05615	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7R78_RS05635	COG0495	leucyl-tRNA aminoacylation
H7R78_RS05640	COG2888	peptidyl-tyrosine sulfation
H7R78_RS05645	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H7R78_RS05650	COG4535	Mg2 and Co2 transporter CorC
H7R78_RS05655	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7R78_RS05660	COG1702	phosphate starvation-inducible protein PhoH
H7R78_RS05665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7R78_RS05670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R78_RS05675	COG1335	isochorismatase
H7R78_RS05680	COG1278	Cold shock
H7R78_RS05695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R78_RS05710	COG2199	diguanylate cyclase activity
H7R78_RS05720	COG3385	transposase activity
H7R78_RS05725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7R78_RS05740	COG1464	Belongs to the NlpA lipoprotein family
H7R78_RS05745	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7R78_RS05750	COG2011	ABC-type metal ion transport system permease component
H7R78_RS05755	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7R78_RS05765	COG0516	GMP reductase activity
H7R78_RS05770	COG4067	protein conserved in archaea
H7R78_RS05770	COG0189	ligase activity
H7R78_RS05790	COG0300	oxidoreductase activity
H7R78_RS05810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7R78_RS05815	COG3214	Protein conserved in bacteria
H7R78_RS05830	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H7R78_RS05835	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H7R78_RS05840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H7R78_RS05845	COG1053	succinate dehydrogenase
H7R78_RS05855	COG0584	glycerophosphoryl diester phosphodiesterase
H7R78_RS05860	COG1511	domain protein
H7R78_RS05860	COG3264	Mechanosensitive ion channel
H7R78_RS05870	COG0739	heme binding
H7R78_RS05885	COG0583	DNA-binding transcription factor activity
H7R78_RS05900	COG0583	DNA-binding transcription factor activity
H7R78_RS05905	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H7R78_RS05945	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7R78_RS05950	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H7R78_RS05960	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H7R78_RS05965	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7R78_RS05970	COG0546	phosphoglycolate phosphatase activity
H7R78_RS05975	COG0180	Tryptophanyl-tRNA synthetase
H7R78_RS05990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7R78_RS06000	COG1012	belongs to the aldehyde dehydrogenase family
H7R78_RS06030	COG2801	Transposase and inactivated derivatives
H7R78_RS06035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R78_RS06050	COG0657	acetylesterase activity
H7R78_RS06060	COG0471	metal ion transport
H7R78_RS06060	COG0490	domain, Protein
H7R78_RS06105	COG0012	GTP binding
H7R78_RS06110	COG0193	aminoacyl-tRNA hydrolase activity
H7R78_RS06115	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7R78_RS06125	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H7R78_RS06130	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H7R78_RS06135	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H7R78_RS06140	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H7R78_RS06145	COG2890	protein-(glutamine-N5) methyltransferase activity
H7R78_RS06155	COG2912	Transglutaminase-like superfamily
H7R78_RS06160	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H7R78_RS06165	COG1301	dicarboxylic acid transport
H7R78_RS06175	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H7R78_RS06190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7R78_RS06195	COG1115	amino acid carrier protein
H7R78_RS06215	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H7R78_RS06225	COG0189	ligase activity
H7R78_RS06230	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H7R78_RS06240	COG3091	SprT-like family
H7R78_RS06250	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H7R78_RS06260	COG2801	Transposase and inactivated derivatives
H7R78_RS06280	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H7R78_RS06285	COG0739	heme binding
H7R78_RS06290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7R78_RS06295	COG3408	Glycogen debranching enzyme
H7R78_RS06295	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H7R78_RS06305	COG1881	PFAM PEBP family protein
H7R78_RS06310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7R78_RS06315	COG0583	DNA-binding transcription factor activity
H7R78_RS06325	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H7R78_RS06335	COG0583	DNA-binding transcription factor activity
H7R78_RS06340	COG1028	Short-chain dehydrogenase reductase Sdr
H7R78_RS06345	COG0616	signal peptide processing
H7R78_RS06350	COG3724	N-succinylarginine dihydrolase activity
H7R78_RS06370	COG0840	transmembrane signaling receptor activity
H7R78_RS06380	COG2971	BadF BadG BcrA BcrD
H7R78_RS06390	COG4608	Belongs to the ABC transporter superfamily
H7R78_RS06395	COG0444	Belongs to the ABC transporter superfamily
H7R78_RS06400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7R78_RS06415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7R78_RS06425	COG0640	Transcriptional regulator
H7R78_RS06430	COG0798	PFAM Bile acid sodium symporter
H7R78_RS06435	COG1393	Belongs to the ArsC family
H7R78_RS06450	COG1677	Flagellar hook-basal body complex protein FliE
H7R78_RS06460	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7R78_RS06515	COG1684	flagellar biosynthetic protein fliR
H7R78_RS06525	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7R78_RS06550	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H7R78_RS06555	COG2198	Histidine kinase
H7R78_RS06555	COG0784	Response regulator, receiver
H7R78_RS06555	COG0643	Histidine kinase
H7R78_RS06565	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7R78_RS06570	COG1360	Flagellar Motor Protein
H7R78_RS06575	COG1192	Involved in chromosome partitioning
H7R78_RS06585	COG0835	chemotaxis
H7R78_RS06600	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7R78_RS06605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7R78_RS06610	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7R78_RS06615	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H7R78_RS06620	COG1138	Cytochrome C-type biogenesis protein
H7R78_RS06625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7R78_RS06635	COG0457	Tetratricopeptide repeat
H7R78_RS06650	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H7R78_RS06655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7R78_RS06655	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7R78_RS06670	COG0259	pyridoxamine-phosphate oxidase activity
H7R78_RS06700	COG3153	acetyltransferase
H7R78_RS06715	COG0800	Aldolase
H7R78_RS06720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R78_RS06730	COG2721	sulfolactate sulfo-lyase activity
H7R78_RS06735	COG0246	Mannitol dehydrogenase
H7R78_RS06780	COG3311	Transcriptional regulator
H7R78_RS06790	COG4251	negative regulation of phosphorylation
H7R78_RS06800	COG4584	PFAM Integrase catalytic
H7R78_RS06805	COG1484	DNA-dependent DNA replication
H7R78_RS06820	COG0582	viral genome integration into host DNA
H7R78_RS06830	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7R78_RS06835	COG2867	negative regulation of translational initiation
H7R78_RS06840	COG2914	Belongs to the UPF0125 (RnfH) family
H7R78_RS06845	COG0702	epimerase
H7R78_RS06850	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R78_RS06855	COG1454	alcohol dehydrogenase
H7R78_RS06865	COG0564	pseudouridine synthase activity
H7R78_RS06870	COG1957	nucleoside hydrolase
H7R78_RS06895	COG1280	lysine exporter protein (LysE YggA)
H7R78_RS06905	COG3263	regulation of cellular component size
H7R78_RS06915	COG1876	peptidase activity
H7R78_RS06920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7R78_RS06925	COG1393	Belongs to the ArsC family
H7R78_RS06935	COG3069	C4-dicarboxylate transmembrane transporter activity
H7R78_RS06940	COG1473	amidohydrolase
H7R78_RS06950	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H7R78_RS06955	COG0017	Asparaginyl-tRNA synthetase
H7R78_RS06975	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7R78_RS06980	COG0156	8-amino-7-oxononanoate synthase activity
H7R78_RS06985	COG2226	methyltransferase
H7R78_RS06985	COG1073	alpha beta
H7R78_RS06990	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H7R78_RS06995	COG0501	Belongs to the peptidase M48B family
H7R78_RS07000	COG3217	Mosc domain protein beta barrel domain protein
H7R78_RS07000	COG0633	Ferredoxin
H7R78_RS07000	COG3217	Mosc domain protein beta barrel domain protein
H7R78_RS07000	COG0633	Ferredoxin
H7R78_RS07010	COG0674	pyruvate-flavodoxin oxidoreductase activity
H7R78_RS07010	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H7R78_RS07010	COG1013	pyruvate-flavodoxin oxidoreductase activity
H7R78_RS07010	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H7R78_RS07015	COG2841	Protein conserved in bacteria
H7R78_RS07025	COG0534	Mate efflux family protein
H7R78_RS07050	COG1454	alcohol dehydrogenase
H7R78_RS07060	COG1309	transcriptional regulator
H7R78_RS07075	COG0791	NLP P60 protein
H7R78_RS07080	COG0583	DNA-binding transcription factor activity
H7R78_RS07100	COG0500	methyltransferase
H7R78_RS07105	COG4106	trans-aconitate 2-methyltransferase activity
H7R78_RS07110	COG1801	Protein of unknown function DUF72
H7R78_RS07115	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H7R78_RS07120	COG0217	transcriptional regulatory protein
H7R78_RS07125	COG2194	sulfuric ester hydrolase activity
H7R78_RS07130	COG1846	Transcriptional regulator
H7R78_RS07130	COG1940	carbohydrate kinase activity
H7R78_RS07135	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7R78_RS07140	COG0363	glucosamine-6-phosphate deaminase activity
H7R78_RS07145	COG2190	(PTS) system
H7R78_RS07145	COG1263	PTS System
H7R78_RS07145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R78_RS07155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7R78_RS07160	COG0735	belongs to the Fur family
H7R78_RS07170	COG0716	FMN binding
H7R78_RS07185	COG0596	Alpha beta hydrolase
H7R78_RS07190	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H7R78_RS07195	COG0033	Phosphoglucomutase
H7R78_RS07205	COG1846	Transcriptional regulator
H7R78_RS07210	COG2951	lytic endotransglycosylase activity
H7R78_RS07215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7R78_RS07220	COG4136	ATPase activity
H7R78_RS07230	COG4134	Bacterial extracellular solute-binding protein
H7R78_RS07235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7R78_RS07240	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7R78_RS07250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7R78_RS07260	COG0729	surface antigen
H7R78_RS07265	COG2911	Protein conserved in bacteria
H7R78_RS07285	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H7R78_RS07295	COG0741	lytic transglycosylase activity
H7R78_RS07310	COG1607	acyl-coa hydrolase
H7R78_RS07325	COG1388	LysM domain
H7R78_RS07325	COG0741	lytic transglycosylase activity
H7R78_RS07330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7R78_RS07335	COG2226	methyltransferase
H7R78_RS07340	COG0328	RNA-DNA hybrid ribonuclease activity
H7R78_RS07360	COG5433	transposase activity
H7R78_RS07385	COG2916	Histone family protein nucleoid-structuring protein H-NS
H7R78_RS07400	COG5642	Protein of unknown function (DUF2384)
H7R78_RS07405	COG2850	peptidyl-arginine hydroxylation
H7R78_RS07450	COG0210	DNA helicase
H7R78_RS07475	COG4974	Belongs to the 'phage' integrase family
H7R78_RS07480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7R78_RS07495	COG1960	acyl-CoA dehydrogenase activity
H7R78_RS07500	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7R78_RS07505	COG0121	glutamine amidotransferase
H7R78_RS07515	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H7R78_RS07540	COG2197	response regulator
H7R78_RS07545	COG3850	Histidine kinase
H7R78_RS07550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7R78_RS07555	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R78_RS07555	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R78_RS07565	COG0243	molybdopterin cofactor binding
H7R78_RS07570	COG0437	4 iron, 4 sulfur cluster binding
H7R78_RS07575	COG0348	domain, Protein
H7R78_RS07585	COG3005	denitrification pathway
H7R78_RS07590	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7R78_RS07595	COG0315	cyclic pyranopterin monophosphate synthase activity
H7R78_RS07600	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H7R78_RS07605	COG0314	molybdopterin synthase activity
H7R78_RS07620	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H7R78_RS07625	COG2267	carboxylic ester hydrolase activity
H7R78_RS07630	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7R78_RS07640	COG0302	gtp cyclohydrolase
H7R78_RS07645	COG0840	transmembrane signaling receptor activity
H7R78_RS07650	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H7R78_RS07660	COG0583	DNA-binding transcription factor activity
H7R78_RS07675	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H7R78_RS07690	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7R78_RS07695	COG1166	arginine decarboxylase activity
H7R78_RS07745	COG5433	transposase activity
H7R78_RS07760	COG2801	Transposase and inactivated derivatives
H7R78_RS07770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7R78_RS07775	COG1187	pseudouridine synthase activity
H7R78_RS07780	COG2807	transmembrane transport
H7R78_RS07790	COG0583	DNA-binding transcription factor activity
H7R78_RS07810	COG2979	Protein of unknown function (DUF533)
H7R78_RS07820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R78_RS07825	COG1271	oxidase subunit
H7R78_RS07830	COG1294	oxidase, subunit
H7R78_RS07840	COG2814	Major facilitator Superfamily
H7R78_RS07845	COG0656	L-ascorbic acid biosynthetic process
H7R78_RS07865	COG0583	DNA-binding transcription factor activity
H7R78_RS07870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7R78_RS07875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7R78_RS07880	COG2271	Major facilitator Superfamily
H7R78_RS07885	COG1349	DNA-binding transcription factor activity
H7R78_RS07895	COG0584	glycerophosphoryl diester phosphodiesterase
H7R78_RS07900	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R78_RS07905	COG1605	Chorismate mutase
H7R78_RS07905	COG0287	Prephenate dehydrogenase
H7R78_RS07915	COG3085	chromosome segregation
H7R78_RS07920	COG4574	serine-type endopeptidase inhibitor activity
H7R78_RS07935	COG0675	Transposase, IS605 OrfB family
H7R78_RS07945	COG4771	TonB-dependent receptor
H7R78_RS07950	COG3083	sulfuric ester hydrolase activity
H7R78_RS07955	COG3082	Protein of unknown function (DUF1414)
H7R78_RS07960	COG3081	Nucleoid-associated protein
H7R78_RS07970	COG1175	transmembrane transport
H7R78_RS07975	COG3833	ABC-type maltose transport systems, permease component
H7R78_RS07980	COG3842	ATPase activity
H7R78_RS07990	COG0596	Alpha beta hydrolase
H7R78_RS08005	COG0425	Belongs to the sulfur carrier protein TusA family
H7R78_RS08010	COG4783	chaperone-mediated protein folding
H7R78_RS08020	COG1393	Belongs to the ArsC family
H7R78_RS08045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R78_RS08050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7R78_RS08055	COG2431	L-lysine efflux transmembrane transporter activity
H7R78_RS08065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R78_RS08075	COG4160	amino acid transport
H7R78_RS08085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7R78_RS08095	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R78_RS08100	COG2373	Large extracellular alpha-helical protein
H7R78_RS08105	COG4953	penicillin-binding protein 1C
H7R78_RS08115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7R78_RS08115	COG0301	tRNA thio-modification
H7R78_RS08130	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7R78_RS08135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7R78_RS08140	COG1334	flagellar protein FlaG
H7R78_RS08175	COG2089	acid synthase
H7R78_RS08185	COG1083	cytidylyl-transferase
H7R78_RS08210	COG0318	PFAM AMP-dependent synthetase and ligase
H7R78_RS08225	COG1216	Glycosyl transferase, family 2
H7R78_RS08235	COG0562	UDP-galactopyranose mutase
H7R78_RS08245	COG0438	transferase activity, transferring glycosyl groups
H7R78_RS08290	COG5433	transposase activity
H7R78_RS08295	COG0438	transferase activity, transferring glycosyl groups
H7R78_RS08300	COG0297	glycogen (starch) synthase activity
H7R78_RS08320	COG0529	Catalyzes the synthesis of activated sulfate
H7R78_RS08330	COG3848	Pyruvate phosphate dikinase
H7R78_RS08330	COG0574	Belongs to the PEP-utilizing enzyme family
H7R78_RS08335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7R78_RS08335	COG0512	Glutamine amidotransferase of anthranilate synthase
H7R78_RS08340	COG1213	nucleotidyl transferase
H7R78_RS08345	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7R78_RS08350	COG1086	Polysaccharide biosynthesis protein
H7R78_RS08355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7R78_RS08365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7R78_RS08395	COG0346	lactoylglutathione lyase activity
H7R78_RS08400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7R78_RS08405	COG4660	Part of a membrane complex involved in electron transport
H7R78_RS08410	COG4659	FMN binding
H7R78_RS08415	COG4658	electron transport chain
H7R78_RS08425	COG2878	Part of a membrane complex involved in electron transport
H7R78_RS08430	COG4657	Part of a membrane complex involved in electron transport
H7R78_RS08435	COG0697	spore germination
H7R78_RS08455	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7R78_RS08460	COG1288	antiporter activity
H7R78_RS08465	COG0436	Aminotransferase
H7R78_RS08475	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7R78_RS08480	COG2027	D-alanyl-D-alanine carboxypeptidase
H7R78_RS08485	COG1061	Type III restriction enzyme res subunit
H7R78_RS08490	COG1566	PFAM secretion protein HlyD family protein
H7R78_RS08505	COG0675	Transposase, IS605 OrfB family
H7R78_RS08515	COG1966	Carbon starvation protein
H7R78_RS08520	COG3279	Response regulator of the LytR AlgR family
H7R78_RS08525	COG3275	phosphorelay sensor kinase activity
H7R78_RS08535	COG1454	alcohol dehydrogenase
H7R78_RS08535	COG1012	belongs to the aldehyde dehydrogenase family
H7R78_RS08540	COG2095	MarC family integral membrane protein
H7R78_RS08550	COG0601	transmembrane transport
H7R78_RS08555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7R78_RS08560	COG0444	Belongs to the ABC transporter superfamily
H7R78_RS08570	COG0861	Integral membrane protein TerC family
H7R78_RS08575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7R78_RS08585	COG1301	dicarboxylic acid transport
H7R78_RS08605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7R78_RS08620	COG0537	adenosine 5'-monophosphoramidase activity
H7R78_RS08655	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R78_RS08660	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R78_RS08675	COG2354	Protein conserved in bacteria
H7R78_RS08680	COG1164	Oligoendopeptidase f
H7R78_RS08685	COG1164	Oligoendopeptidase f
H7R78_RS08690	COG3150	esterase
H7R78_RS08695	COG1252	NADH dehydrogenase
H7R78_RS08700	COG0393	Putative heavy-metal-binding
H7R78_RS08705	COG1368	sulfuric ester hydrolase activity
H7R78_RS08715	COG0527	aspartate kinase activity
H7R78_RS08720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7R78_RS08720	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H7R78_RS08725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R78_RS08750	COG0583	DNA-binding transcription factor activity
H7R78_RS08755	COG1620	l-lactate permease
H7R78_RS08760	COG0247	lactate metabolic process
H7R78_RS08765	COG1139	Iron-sulfur cluster binding protein
H7R78_RS08805	COG0577	efflux transmembrane transporter activity
H7R78_RS08810	COG1136	(ABC) transporter
H7R78_RS08830	COG2814	Major facilitator Superfamily
H7R78_RS08855	COG0672	)-iron permease
H7R78_RS08890	COG2308	Evidence 4 Homologs of previously reported genes of
H7R78_RS08930	COG0659	secondary active sulfate transmembrane transporter activity
H7R78_RS08950	COG4974	Belongs to the 'phage' integrase family
H7R78_RS08970	COG4584	PFAM Integrase catalytic
H7R78_RS08975	COG1484	DNA-dependent DNA replication
H7R78_RS09035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7R78_RS09040	COG3039	Transposase
H7R78_RS09045	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H7R78_RS09050	COG0326	Molecular chaperone. Has ATPase activity
H7R78_RS09055	COG0563	adenylate kinase activity
H7R78_RS09060	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7R78_RS09065	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H7R78_RS09070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R78_RS09075	COG0840	transmembrane signaling receptor activity
H7R78_RS09090	COG5001	Diguanylate cyclase
H7R78_RS09090	COG3300	MHYT domain
H7R78_RS09095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7R78_RS09115	COG1021	2,3-dihydroxybenzoate-AMP ligase
H7R78_RS09120	COG3433	isochorismatase activity
H7R78_RS09120	COG1535	isochorismatase
H7R78_RS09125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7R78_RS09130	COG1028	Short-chain dehydrogenase reductase Sdr
H7R78_RS09140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7R78_RS09155	COG1120	ATPase activity
H7R78_RS09160	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R78_RS09165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R78_RS09170	COG4771	TonB-dependent receptor
H7R78_RS09210	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H7R78_RS09215	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H7R78_RS09220	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R78_RS09225	COG0861	Integral membrane protein TerC family
H7R78_RS09240	COG1022	Amp-dependent synthetase and ligase
H7R78_RS09245	COG0295	cytidine deaminase activity
H7R78_RS09250	COG1346	cytolysis
H7R78_RS09255	COG1380	Effector of murein hydrolase LrgA
H7R78_RS09260	COG3345	alpha-galactosidase
H7R78_RS09270	COG2925	Exonuclease
H7R78_RS09275	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7R78_RS09280	COG0392	lysyltransferase activity
H7R78_RS09280	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H7R78_RS09295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7R78_RS09300	COG0436	Aminotransferase
H7R78_RS09305	COG0583	DNA-binding transcription factor activity
H7R78_RS09310	COG2160	L-arabinose isomerase activity
H7R78_RS09320	COG1069	ribulokinase activity
H7R78_RS09325	COG1879	ABC-type sugar transport system periplasmic component
H7R78_RS09330	COG1129	ABC transporter
H7R78_RS09335	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7R78_RS09345	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7R78_RS09350	COG0254	rRNA binding
H7R78_RS09365	COG1451	nucleotide metabolic process
H7R78_RS09380	COG3069	C4-dicarboxylate transmembrane transporter activity
H7R78_RS09390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R78_RS09390	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H7R78_RS09395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7R78_RS09415	COG2009	succinate dehydrogenase
H7R78_RS09420	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H7R78_RS09435	COG0567	Dehydrogenase, E1 component
H7R78_RS09440	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7R78_RS09445	COG0045	succinate-CoA ligase (ADP-forming) activity
H7R78_RS09450	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H7R78_RS09460	COG4584	PFAM Integrase catalytic
H7R78_RS09465	COG1484	DNA-dependent DNA replication
H7R78_RS09505	COG2983	Belongs to the UPF0260 family
H7R78_RS09510	COG1882	Formate acetyltransferase
H7R78_RS09515	COG2116	formate transmembrane transporter activity
H7R78_RS09520	COG1944	ATP diphosphatase activity
H7R78_RS09535	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7R78_RS09540	COG1278	Cold shock
H7R78_RS09545	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H7R78_RS09550	COG0542	response to heat
H7R78_RS09555	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H7R78_RS09560	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H7R78_RS09565	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H7R78_RS09570	COG3134	Outer membrane lipoprotein
H7R78_RS09575	COG3706	GGDEF domain
H7R78_RS09580	COG0492	ferredoxin-NADP+ reductase activity
H7R78_RS09585	COG0686	Belongs to the AlaDH PNT family
H7R78_RS09595	COG1674	ftsk spoiiie
H7R78_RS09595	COG0531	amino acid
H7R78_RS09600	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H7R78_RS09605	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7R78_RS09610	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7R78_RS09615	COG1286	toxin biosynthetic process
H7R78_RS09620	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H7R78_RS09630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R78_RS09630	COG1263	PTS System
H7R78_RS09645	COG4172	Belongs to the ABC transporter superfamily
H7R78_RS09655	COG4171	peptide transport system, permease
H7R78_RS09670	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H7R78_RS09675	COG1842	Phage shock protein A
H7R78_RS09690	COG3106	COG3106 Predicted ATPase
H7R78_RS09695	COG3768	UPF0283 membrane protein
H7R78_RS09705	COG2154	pterin-4-alpha-carbinolamine dehydratase
H7R78_RS09720	COG2199	diguanylate cyclase activity
H7R78_RS09725	COG2885	chlorophyll binding
H7R78_RS09755	COG0675	Transposase, IS605 OrfB family
H7R78_RS09770	COG0516	GMP reductase activity
H7R78_RS09770	COG0517	IMP dehydrogenase activity
H7R78_RS09775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7R78_RS09775	COG0519	Catalyzes the synthesis of GMP from XMP
H7R78_RS09800	COG1846	Transcriptional regulator
H7R78_RS09820	COG2062	phosphohistidine phosphatase, SixA
H7R78_RS09830	COG0697	spore germination
H7R78_RS09845	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H7R78_RS09850	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7R78_RS09860	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7R78_RS09865	COG1136	(ABC) transporter
H7R78_RS09870	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7R78_RS09875	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H7R78_RS09885	COG0544	peptidyl-prolyl cis-trans isomerase activity
H7R78_RS09890	COG0740	serine-type endopeptidase activity
H7R78_RS09895	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H7R78_RS09900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7R78_RS09905	COG0776	regulation of translation
H7R78_RS09910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7R78_RS09915	COG0488	(ABC) transporter
H7R78_RS09920	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7R78_RS09925	COG3162	membrane
H7R78_RS09940	COG1024	Enoyl-CoA hydratase
H7R78_RS09945	COG1115	amino acid carrier protein
H7R78_RS09955	COG3228	Belongs to the MtfA family
H7R78_RS09960	COG1584	GPR1 FUN34 yaaH family protein
H7R78_RS09985	COG1024	Enoyl-CoA hydratase
H7R78_RS09990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7R78_RS09995	COG1960	acyl-CoA dehydrogenase activity
H7R78_RS10005	COG1960	acyl-CoA dehydrogenase activity
H7R78_RS10010	COG1024	Enoyl-CoA hydratase
H7R78_RS10015	COG1024	Enoyl-CoA hydratase
H7R78_RS10025	COG1028	Short-chain dehydrogenase reductase Sdr
H7R78_RS10035	COG0730	response to heat
H7R78_RS10050	COG0583	DNA-binding transcription factor activity
H7R78_RS10055	COG2072	flavoprotein involved in K transport
H7R78_RS10080	COG0531	amino acid
H7R78_RS10085	COG1012	belongs to the aldehyde dehydrogenase family
H7R78_RS10090	COG2197	response regulator
H7R78_RS10095	COG2205	protein histidine kinase activity
H7R78_RS10095	COG0784	Response regulator, receiver
H7R78_RS10100	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7R78_RS10110	COG1879	ABC-type sugar transport system periplasmic component
H7R78_RS10120	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7R78_RS10125	COG0243	molybdopterin cofactor binding
H7R78_RS10135	COG0583	DNA-binding transcription factor activity
H7R78_RS10140	COG2723	6-phospho-beta-galactosidase activity
H7R78_RS10150	COG0583	DNA-binding transcription factor activity
H7R78_RS10165	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H7R78_RS10170	COG0673	inositol 2-dehydrogenase activity
H7R78_RS10175	COG0583	DNA-binding transcription factor activity
H7R78_RS10185	COG1560	Kdo2-lipid A biosynthetic process
H7R78_RS10190	COG1560	Kdo2-lipid A biosynthetic process
H7R78_RS10205	COG0417	DNA replication proofreading
H7R78_RS10235	COG0534	Mate efflux family protein
H7R78_RS10245	COG0307	riboflavin synthase, alpha
H7R78_RS10260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R78_RS10265	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H7R78_RS10270	COG0697	spore germination
H7R78_RS10275	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7R78_RS10300	COG2996	Protein conserved in bacteria
H7R78_RS10315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7R78_RS10320	COG3099	Belongs to the UPF0263 family
H7R78_RS10325	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H7R78_RS10330	COG2894	cell division
H7R78_RS10335	COG0850	regulation of cytokinetic process
H7R78_RS10340	COG3100	YcgL domain-containing protein
H7R78_RS10350	COG1760	l-serine dehydratase
H7R78_RS10355	COG1760	l-serine dehydratase
H7R78_RS10360	COG3123	guanosine phosphorylase activity
H7R78_RS10365	COG1301	dicarboxylic acid transport
H7R78_RS10380	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H7R78_RS10385	COG2067	long-chain fatty acid transport protein
H7R78_RS10390	COG2067	long-chain fatty acid transport protein
H7R78_RS10400	COG1595	DNA-templated transcription, initiation
H7R78_RS10430	COG0714	Associated with various cellular activities
H7R78_RS10435	COG0183	Belongs to the thiolase family
H7R78_RS10440	COG1024	Enoyl-CoA hydratase
H7R78_RS10440	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7R78_RS10450	COG4681	YaeQ
H7R78_RS10475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R78_RS10490	COG3134	Outer membrane lipoprotein
H7R78_RS10505	COG0675	Transposase, IS605 OrfB family
H7R78_RS10515	COG2378	regulation of single-species biofilm formation
H7R78_RS10525	COG0140	phosphoribosyl-ATP diphosphatase activity
H7R78_RS10525	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H7R78_RS10530	COG0107	imidazoleglycerol-phosphate synthase activity
H7R78_RS10535	COG2205	protein histidine kinase activity
H7R78_RS10535	COG2198	Histidine kinase
H7R78_RS10535	COG0784	Response regulator, receiver
H7R78_RS10540	COG2199	diguanylate cyclase activity
H7R78_RS10545	COG3437	response regulator, receiver
H7R78_RS10550	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H7R78_RS10555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7R78_RS10560	COG0131	Imidazoleglycerol-phosphate dehydratase
H7R78_RS10560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7R78_RS10565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7R78_RS10570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H7R78_RS10575	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H7R78_RS10585	COG1199	ATP-dependent helicase activity
H7R78_RS10590	COG1214	PFAM Peptidase M22, glycoprotease
H7R78_RS10600	COG0596	Alpha beta hydrolase
H7R78_RS10605	COG0318	PFAM AMP-dependent synthetase and ligase
H7R78_RS10620	COG0697	spore germination
H7R78_RS10630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7R78_RS10635	COG2832	Protein of unknown function (DUF454)
H7R78_RS10640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7R78_RS10650	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H7R78_RS10655	COG0583	DNA-binding transcription factor activity
H7R78_RS10665	COG3314	Sporulation integral membrane protein YlbJ
H7R78_RS10670	COG2197	response regulator
H7R78_RS10680	COG0517	IMP dehydrogenase activity
H7R78_RS10680	COG0617	tRNA 3'-terminal CCA addition
H7R78_RS10680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7R78_RS10685	COG1643	Atp-dependent helicase
H7R78_RS10695	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H7R78_RS10710	COG0675	Transposase, IS605 OrfB family
H7R78_RS10720	COG3437	response regulator, receiver
H7R78_RS10725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7R78_RS10730	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H7R78_RS10735	COG0709	Synthesizes selenophosphate from selenide and ATP
H7R78_RS10750	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7R78_RS10755	COG0840	transmembrane signaling receptor activity
H7R78_RS10760	COG1254	Belongs to the acylphosphatase family
H7R78_RS10770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R78_RS10770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R78_RS10775	COG0489	protein tyrosine kinase activity
H7R78_RS10780	COG0572	uridine kinase
H7R78_RS10785	COG0717	Belongs to the dCTP deaminase family
H7R78_RS10790	COG0306	phosphate transporter
H7R78_RS10795	COG1530	ribonuclease E activity
H7R78_RS10800	COG0564	pseudouridine synthase activity
H7R78_RS10815	COG1399	metal-binding, possibly nucleic acid-binding protein
H7R78_RS10820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H7R78_RS10825	COG0416	fatty acid biosynthetic process
H7R78_RS10830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7R78_RS10840	COG1028	Short-chain dehydrogenase reductase Sdr
H7R78_RS10845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7R78_RS10850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7R78_RS10855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7R78_RS10860	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7R78_RS10865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H7R78_RS10870	COG0470	DNA polymerase III
H7R78_RS10875	COG0084	hydrolase, TatD family'
H7R78_RS10890	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H7R78_RS10890	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7R78_RS10895	COG3008	intermembrane lipid transfer
H7R78_RS10900	COG2995	paraquat-inducible protein a
H7R78_RS10915	COG3141	response to X-ray
H7R78_RS10925	COG1067	ATP-dependent peptidase activity
H7R78_RS10930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7R78_RS10945	COG0488	(ABC) transporter
H7R78_RS10955	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7R78_RS10955	COG0116	Belongs to the methyltransferase superfamily
H7R78_RS10965	COG0167	dihydroorotate dehydrogenase activity
H7R78_RS10970	COG2902	Dehydrogenase
H7R78_RS10980	COG0308	aminopeptidase N
H7R78_RS10990	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
H7R78_RS10995	COG1956	GAF domain-containing protein
H7R78_RS11010	COG3278	Belongs to the heme-copper respiratory oxidase family
H7R78_RS11025	COG2010	Cytochrome c
H7R78_RS11035	COG2217	Heavy metal translocating P-type atpase
H7R78_RS11050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7R78_RS11055	COG0589	response to stress
H7R78_RS11060	COG0037	tRNA processing
H7R78_RS11085	COG0625	glutathione transferase activity
H7R78_RS11090	COG1869	D-ribose catabolic process
H7R78_RS11095	COG1129	ABC transporter
H7R78_RS11100	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7R78_RS11105	COG1879	ABC-type sugar transport system periplasmic component
H7R78_RS11110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R78_RS11115	COG1609	Transcriptional regulator
H7R78_RS11125	COG0675	Transposase, IS605 OrfB family
H7R78_RS11160	COG0776	regulation of translation
H7R78_RS11165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R78_RS11165	COG0072	phenylalanine-tRNA ligase activity
H7R78_RS11170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H7R78_RS11175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H7R78_RS11180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H7R78_RS11185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H7R78_RS11190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7R78_RS11210	COG0675	Transposase, IS605 OrfB family
H7R78_RS11235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7R78_RS11245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7R78_RS11250	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7R78_RS11255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R78_RS11260	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H7R78_RS11265	COG3313	Fe-S protein
H7R78_RS11270	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H7R78_RS11270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R78_RS11270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R78_RS11275	COG1105	Belongs to the carbohydrate kinase PfkB family
H7R78_RS11280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R78_RS11280	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R78_RS11285	COG1609	Transcriptional regulator
H7R78_RS11290	COG0814	amino acid
H7R78_RS11300	COG5654	RES domain protein
H7R78_RS11305	COG0513	Belongs to the DEAD box helicase family
H7R78_RS11315	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H7R78_RS11320	COG2890	protein-(glutamine-N5) methyltransferase activity
H7R78_RS11325	COG2840	Smr protein MutS2
H7R78_RS11360	COG2824	Alkylphosphonate utilization operon protein PhnA
H7R78_RS11385	COG0675	Transposase, IS605 OrfB family
H7R78_RS11420	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H7R78_RS11425	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H7R78_RS11435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7R78_RS11440	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H7R78_RS11450	COG0205	6-phosphofructokinase activity
H7R78_RS11460	COG1473	amidohydrolase
H7R78_RS11465	COG1011	Hydrolase
H7R78_RS11470	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7R78_RS11515	COG3593	DNA synthesis involved in DNA repair
H7R78_RS11530	COG0583	DNA-binding transcription factor activity
H7R78_RS11535	COG0730	response to heat
H7R78_RS11540	COG3148	PFAM DTW domain containing protein
H7R78_RS11545	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7R78_RS11555	COG0386	Belongs to the glutathione peroxidase family
H7R78_RS11560	COG0513	Belongs to the DEAD box helicase family
H7R78_RS11575	COG1742	UPF0060 membrane protein
H7R78_RS11600	COG2329	Antibiotic biosynthesis monooxygenase
H7R78_RS11605	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7R78_RS11625	COG3243	poly(R)-hydroxyalkanoic acid synthase
H7R78_RS11635	COG2501	S4 domain
H7R78_RS11650	COG1132	(ABC) transporter
H7R78_RS11655	COG1132	(ABC) transporter
H7R78_RS11665	COG3118	belongs to the thioredoxin family
H7R78_RS11670	COG0471	metal ion transport
H7R78_RS11680	COG0058	SHG alpha-glucan phosphorylase activity
H7R78_RS11715	COG0814	amino acid
H7R78_RS11720	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H7R78_RS11725	COG0514	ATP-dependent DNA helicase (RecQ)
H7R78_RS11730	COG2766	serine protein kinase
H7R78_RS11735	COG2718	Belongs to the UPF0229 family
H7R78_RS11740	COG2719	SpoVR family
H7R78_RS11745	COG3385	transposase activity
H7R78_RS11750	COG2186	Transcriptional regulator
H7R78_RS11755	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7R78_RS11760	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H7R78_RS11765	COG3385	transposase activity
H7R78_RS11770	COG0586	Pfam SNARE associated Golgi protein
H7R78_RS11780	COG0556	nucleotide-excision repair
H7R78_RS11795	COG2985	domain, Protein
H7R78_RS11795	COG0569	domain protein
H7R78_RS11805	COG0675	Transposase, IS605 OrfB family
H7R78_RS11815	COG3181	Tripartite tricarboxylate transporter family receptor
H7R78_RS11830	COG4565	transcriptional regulatory protein
H7R78_RS11835	COG3290	protein histidine kinase activity
H7R78_RS11840	COG1940	carbohydrate kinase activity
H7R78_RS11840	COG1846	Transcriptional regulator
H7R78_RS11850	COG3012	SEC-C Motif Domain Protein
H7R78_RS11855	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H7R78_RS11860	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
H7R78_RS11865	COG0247	lactate metabolic process
H7R78_RS11875	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H7R78_RS11880	COG0437	4 iron, 4 sulfur cluster binding
H7R78_RS11885	COG3301	Polysulphide reductase, NrfD
H7R78_RS11890	COG1138	Cytochrome C-type biogenesis protein
H7R78_RS11895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7R78_RS11900	COG3088	subunit of a heme lyase
H7R78_RS11900	COG4235	cytochrome complex assembly
H7R78_RS11915	COG3046	protein related to deoxyribodipyrimidine photolyase
H7R78_RS11920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R78_RS11935	COG0517	IMP dehydrogenase activity
H7R78_RS11935	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7R78_RS11935	COG0617	tRNA 3'-terminal CCA addition
H7R78_RS11945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7R78_RS11950	COG0583	DNA-binding transcription factor activity
H7R78_RS11960	COG4774	siderophore transport
H7R78_RS11965	COG2199	diguanylate cyclase activity
H7R78_RS11965	COG2203	Gaf domain
H7R78_RS11970	COG2200	EAL domain
H7R78_RS11975	COG1917	Cupin 2, conserved barrel domain protein
H7R78_RS11975	COG4977	sequence-specific DNA binding
H7R78_RS11980	COG0583	DNA-binding transcription factor activity
H7R78_RS11985	COG2910	NAD(P)H-binding
H7R78_RS11995	COG0626	cystathionine gamma-synthase activity
H7R78_RS12000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H7R78_RS12070	COG5377	YqaJ viral recombinase family
H7R78_RS12095	COG2003	Belongs to the UPF0758 family
H7R78_RS12100	COG3039	Transposase
H7R78_RS12105	COG4584	PFAM Integrase catalytic
H7R78_RS12110	COG1484	DNA-dependent DNA replication
H7R78_RS12120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7R78_RS12145	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H7R78_RS12165	COG4804	nuclease activity
H7R78_RS12190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7R78_RS12275	COG3550	peptidyl-serine autophosphorylation
H7R78_RS12290	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H7R78_RS12335	COG2723	6-phospho-beta-galactosidase activity
H7R78_RS12340	COG2190	(PTS) system
H7R78_RS12340	COG1263	PTS System
H7R78_RS12340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R78_RS12345	COG1737	Transcriptional regulator
H7R78_RS12365	COG1435	thymidine kinase activity
H7R78_RS12370	COG1757	Na H antiporter
H7R78_RS12375	COG2916	Histone family protein nucleoid-structuring protein H-NS
H7R78_RS12380	COG2096	Adenosyltransferase
H7R78_RS12385	COG3530	Putative quorum-sensing-regulated virulence factor
H7R78_RS12390	COG0602	queuosine metabolic process
H7R78_RS12395	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7R78_RS12415	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H7R78_RS12425	COG0776	regulation of translation
H7R78_RS12430	COG0539	negative regulation of cytoplasmic translation
H7R78_RS12435	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H7R78_RS12440	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7R78_RS12470	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H7R78_RS12475	COG3300	MHYT domain
H7R78_RS12475	COG5001	Diguanylate cyclase
H7R78_RS12485	COG0583	DNA-binding transcription factor activity
H7R78_RS12490	COG0745	RESPONSE REGULATOR receiver
H7R78_RS12515	COG4989	oxidoreductase activity
H7R78_RS12520	COG0724	RNA recognition motif
H7R78_RS12530	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
H7R78_RS12540	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H7R78_RS12560	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7R78_RS12565	COG1360	Flagellar Motor Protein
H7R78_RS12570	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R78_RS12575	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R78_RS12580	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R78_RS12580	COG0649	NAD binding
H7R78_RS12595	COG1034	ATP synthesis coupled electron transport
H7R78_RS12600	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H7R78_RS12605	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R78_RS12610	COG0839	Belongs to the complex I subunit 6 family
H7R78_RS12615	COG0713	ATP synthesis coupled electron transport
H7R78_RS12625	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R78_RS12630	COG1007	ATP synthesis coupled electron transport
H7R78_RS12635	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7R78_RS12635	COG0047	phosphoribosylformylglycinamidine synthase activity
H7R78_RS12640	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7R78_RS12650	COG1645	bacterial-type flagellum-dependent swarming motility
H7R78_RS12655	COG1160	GTP binding
H7R78_RS12660	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R78_RS12665	COG2976	Protein conserved in bacteria
H7R78_RS12670	COG0124	histidyl-tRNA synthetase
H7R78_RS12680	COG1426	Protein conserved in bacteria
H7R78_RS12690	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7R78_RS12695	COG0105	UTP biosynthetic process
H7R78_RS12710	COG0633	Ferredoxin
H7R78_RS12715	COG0443	Heat shock 70 kDa protein
H7R78_RS12720	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H7R78_RS12730	COG0822	iron-sulfur transferase activity
H7R78_RS12735	COG1104	cysteine desulfurase activity
H7R78_RS12750	COG3154	lipid carrier protein
H7R78_RS12755	COG0826	peptidase U32
H7R78_RS12760	COG0826	peptidase U32
H7R78_RS12770	COG2897	thiosulfate sulfurtransferase activity
H7R78_RS12775	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R78_RS12780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R78_RS12785	COG1862	Preprotein translocase
H7R78_RS12790	COG0343	queuine tRNA-ribosyltransferase activity
H7R78_RS12795	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H7R78_RS12800	COG0517	IMP dehydrogenase activity
H7R78_RS12805	COG0450	alkyl hydroperoxide reductase
H7R78_RS12810	COG3634	alkyl hydroperoxide reductase activity
H7R78_RS12835	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7R78_RS12835	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7R78_RS12840	COG0509	glycine decarboxylation via glycine cleavage system
H7R78_RS12845	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7R78_RS12850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R78_RS12855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R78_RS12875	COG2814	Major facilitator Superfamily
H7R78_RS12880	COG0444	Belongs to the ABC transporter superfamily
H7R78_RS12885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7R78_RS12890	COG0601	transmembrane transport
H7R78_RS12900	COG0625	glutathione transferase activity
H7R78_RS12905	COG0625	glutathione transferase activity
H7R78_RS12915	COG0483	inositol monophosphate 1-phosphatase activity
H7R78_RS12930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7R78_RS12935	COG2056	Na+-H+ antiporter family
H7R78_RS12940	COG2814	Major facilitator Superfamily
H7R78_RS12945	COG0583	DNA-binding transcription factor activity
H7R78_RS12950	COG5001	Diguanylate cyclase
H7R78_RS12965	COG2050	protein possibly involved in aromatic compounds catabolism
H7R78_RS12975	COG0247	lactate metabolic process
H7R78_RS12975	COG0277	FAD linked oxidase domain protein
H7R78_RS12990	COG1253	flavin adenine dinucleotide binding
H7R78_RS12995	COG1902	pentaerythritol trinitrate reductase activity
H7R78_RS13005	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H7R78_RS13010	COG0647	UMP catabolic process
H7R78_RS13020	COG0367	asparagine synthase
H7R78_RS13035	COG0625	glutathione transferase activity
H7R78_RS13045	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H7R78_RS13060	COG0564	pseudouridine synthase activity
H7R78_RS13065	COG5001	Diguanylate cyclase
H7R78_RS13075	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H7R78_RS13110	COG0670	Belongs to the BI1 family
H7R78_RS13115	COG1289	transmembrane transporter activity
H7R78_RS13120	COG2920	part of a sulfur-relay system
H7R78_RS13125	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H7R78_RS13130	COG0285	dihydrofolate synthase activity
H7R78_RS13135	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7R78_RS13140	COG0101	tRNA pseudouridine synthase activity
H7R78_RS13150	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7R78_RS13155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7R78_RS13165	COG1464	Belongs to the NlpA lipoprotein family
H7R78_RS13190	COG1119	ATPase activity
H7R78_RS13195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7R78_RS13195	COG0574	Belongs to the PEP-utilizing enzyme family
H7R78_RS13200	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H7R78_RS13210	COG1113	amino acid transport
H7R78_RS13260	COG5433	transposase activity
H7R78_RS13285	COG1242	4 iron, 4 sulfur cluster binding
H7R78_RS13290	COG0067	glutamate synthase
H7R78_RS13290	COG0069	glutamate synthase activity
H7R78_RS13290	COG0070	glutamate synthase
H7R78_RS13295	COG0493	'glutamate synthase
H7R78_RS13300	COG1126	abc transporter atp-binding protein
H7R78_RS13305	COG0765	amino acid transport
H7R78_RS13310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R78_RS13335	COG4104	PAAR repeat-containing protein
H7R78_RS13345	COG0513	Belongs to the DEAD box helicase family
H7R78_RS13380	COG3706	GGDEF domain
H7R78_RS13385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7R78_RS13390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7R78_RS13395	COG0505	Belongs to the CarA family
H7R78_RS13400	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H7R78_RS13410	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H7R78_RS13415	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H7R78_RS13420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7R78_RS13425	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7R78_RS13430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R78_RS13435	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
H7R78_RS13440	COG4139	cobalamin transport
H7R78_RS13465	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H7R78_RS13475	COG0023	Translation Initiation Factor
H7R78_RS13480	COG2119	membrane
H7R78_RS13515	COG2203	Gaf domain
H7R78_RS13515	COG2199	diguanylate cyclase activity
H7R78_RS13520	COG3039	Transposase
H7R78_RS13535	COG0215	cysteine-tRNA ligase activity
H7R78_RS13540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7R78_RS13550	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R78_RS13555	COG2261	transglycosylase associated protein
H7R78_RS13560	COG1309	transcriptional regulator
H7R78_RS13565	COG0604	alcohol dehydrogenase
H7R78_RS13580	COG0583	DNA-binding transcription factor activity
H7R78_RS13605	COG0322	excinuclease ABC activity
H7R78_RS13610	COG2197	response regulator
H7R78_RS13615	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H7R78_RS13620	COG2835	tetraacyldisaccharide 4'-kinase activity
H7R78_RS13625	COG1663	tetraacyldisaccharide 4'-kinase activity
H7R78_RS13630	COG1132	(ABC) transporter
H7R78_RS13635	COG2333	competence protein COMEC
H7R78_RS13635	COG0658	competence protein
H7R78_RS13650	COG0433	COG0433 Predicted ATPase
H7R78_RS13655	COG1448	Aminotransferase
H7R78_RS13670	COG5433	transposase activity
H7R78_RS13680	COG1199	ATP-dependent helicase activity
H7R78_RS13695	COG0123	including yeast histone deacetylase and acetoin utilization protein
H7R78_RS13705	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H7R78_RS13710	COG1785	Belongs to the alkaline phosphatase family
H7R78_RS13730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7R78_RS13740	COG0675	Transposase, IS605 OrfB family
H7R78_RS13755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R78_RS13760	COG0765	amino acid transport
H7R78_RS13765	COG1126	abc transporter atp-binding protein
H7R78_RS13775	COG0531	amino acid
H7R78_RS13790	COG1253	flavin adenine dinucleotide binding
H7R78_RS13795	COG0704	Plays a role in the regulation of phosphate uptake
H7R78_RS13800	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7R78_RS13805	COG0581	inorganic phosphate transmembrane transporter activity
H7R78_RS13810	COG0573	inorganic phosphate transmembrane transporter activity
H7R78_RS13815	COG0590	tRNA wobble adenosine to inosine editing
H7R78_RS13830	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H7R78_RS13850	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H7R78_RS13855	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H7R78_RS13860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7R78_RS13865	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H7R78_RS13890	COG2716	regulation of RNA biosynthetic process
H7R78_RS13895	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H7R78_RS13910	COG0675	Transposase, IS605 OrfB family
H7R78_RS13945	COG1705	Flagellar rod assembly protein muramidase FlgJ
H7R78_RS13945	COG3951	Flagellar rod assembly protein muramidase FlgJ
H7R78_RS13950	COG1706	bacterial-type flagellum-dependent cell motility
H7R78_RS13955	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H7R78_RS13970	COG4786	Flagellar basal body rod
H7R78_RS13985	COG1815	bacterial-type flagellum-dependent cell motility
H7R78_RS13990	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H7R78_RS13995	COG0784	Response regulator, receiver
H7R78_RS13995	COG0835	chemotaxis
H7R78_RS14000	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
H7R78_RS14015	COG0622	Phosphoesterase
H7R78_RS14020	COG0675	Transposase, IS605 OrfB family
H7R78_RS14030	COG4166	transmembrane transport
H7R78_RS14050	COG0675	Transposase, IS605 OrfB family
H7R78_RS14060	COG0697	spore germination
H7R78_RS14065	COG4166	transmembrane transport
H7R78_RS14095	COG1278	Cold shock
H7R78_RS14110	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7R78_RS14135	COG0675	Transposase, IS605 OrfB family
H7R78_RS14145	COG3132	Protein of unknown function, DUF480
H7R78_RS14150	COG4584	PFAM Integrase catalytic
H7R78_RS14155	COG1484	DNA-dependent DNA replication
H7R78_RS14165	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R78_RS14185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7R78_RS14225	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7R78_RS14255	COG1216	Glycosyl transferase, family 2
H7R78_RS14290	COG1028	Short-chain dehydrogenase reductase Sdr
H7R78_RS14295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7R78_RS14300	COG1083	cytidylyl-transferase
H7R78_RS14325	COG1091	dTDP-4-dehydrorhamnose reductase activity
H7R78_RS14355	COG1737	Transcriptional regulator
H7R78_RS14360	COG0469	pyruvate kinase activity
H7R78_RS14370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R78_RS14375	COG1960	acyl-CoA dehydrogenase activity
H7R78_RS14385	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H7R78_RS14405	COG0583	DNA-binding transcription factor activity
H7R78_RS14410	COG4584	PFAM Integrase catalytic
H7R78_RS14415	COG1484	DNA-dependent DNA replication
H7R78_RS14430	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7R78_RS14445	COG2003	Belongs to the UPF0758 family
H7R78_RS14525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R78_RS14530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R78_RS14535	COG1309	transcriptional regulator
H7R78_RS14550	COG1946	Acyl-CoA thioesterase
H7R78_RS14560	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H7R78_RS14570	COG0009	L-threonylcarbamoyladenylate synthase
H7R78_RS14575	COG0613	PHP domain protein
H7R78_RS14580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7R78_RS14585	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7R78_RS14585	COG0512	Glutamine amidotransferase of anthranilate synthase
H7R78_RS14590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7R78_RS14595	COG0135	phosphoribosylanthranilate isomerase activity
H7R78_RS14595	COG0134	indole-3-glycerol-phosphate synthase activity
H7R78_RS14600	COG0133	tryptophan synthase activity
H7R78_RS14605	COG0159	tryptophan synthase activity
H7R78_RS14610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7R78_RS14630	COG1396	sequence-specific DNA binding
H7R78_RS14655	COG0583	DNA-binding transcription factor activity
H7R78_RS14665	COG4521	taurine ABC transporter
H7R78_RS14670	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H7R78_RS14675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7R78_RS14680	COG2175	clavaminate synthase activity
H7R78_RS14685	COG5507	3-demethylubiquinone-9 3-methyltransferase
H7R78_RS14690	COG2814	Major facilitator Superfamily
H7R78_RS14700	COG0109	protoheme IX farnesyltransferase activity
H7R78_RS14705	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H7R78_RS14710	COG1845	cytochrome c oxidase, subunit III
H7R78_RS14715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7R78_RS14720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7R78_RS14725	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7R78_RS14730	COG0583	DNA-binding transcription factor activity
H7R78_RS14750	COG1846	Transcriptional regulator
H7R78_RS14765	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
H7R78_RS14780	COG0745	RESPONSE REGULATOR receiver
H7R78_RS14790	COG0708	Exodeoxyribonuclease III
H7R78_RS14800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R78_RS14805	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R78_RS14820	COG0095	Lipoate-protein ligase
H7R78_RS14860	COG1285	pathogenesis
H7R78_RS14890	COG0484	heat shock protein binding
H7R78_RS14895	COG0443	Heat shock 70 kDa protein
H7R78_RS14900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H7R78_RS14905	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7R78_RS14910	COG3706	GGDEF domain
H7R78_RS14915	COG0497	DNA recombination
H7R78_RS14925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R78_RS14930	COG1136	(ABC) transporter
H7R78_RS14930	COG0577	efflux transmembrane transporter activity
H7R78_RS14935	COG1538	Outer membrane efflux protein
H7R78_RS14940	COG2375	cellular response to nickel ion
H7R78_RS14955	COG2916	Histone family protein nucleoid-structuring protein H-NS
H7R78_RS14960	COG0583	DNA-binding transcription factor activity
H7R78_RS14965	COG3048	D-serine ammonia-lyase activity
H7R78_RS14975	COG0538	isocitrate dehydrogenase activity
H7R78_RS15015	COG1187	pseudouridine synthase activity
H7R78_RS15025	COG0482	sulfurtransferase activity
H7R78_RS15030	COG2915	High frequency lysogenization protein hflD homolog
H7R78_RS15035	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7R78_RS15040	COG2850	peptidyl-arginine hydroxylation
H7R78_RS15050	COG1196	nuclear chromosome segregation
H7R78_RS15050	COG3264	Mechanosensitive ion channel
H7R78_RS15080	COG0281	malic enzyme
H7R78_RS15085	COG0746	molybdenum cofactor guanylyltransferase activity
H7R78_RS15090	COG1763	Mo-molybdopterin cofactor biosynthetic process
H7R78_RS15095	COG1289	transmembrane transporter activity
H7R78_RS15100	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7R78_RS15130	COG3220	belongs to the UPF0276 family
H7R78_RS15140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7R78_RS15155	COG2815	serine threonine protein kinase
H7R78_RS15155	COG0515	serine threonine protein kinase
H7R78_RS15165	COG4319	ketosteroid isomerase
H7R78_RS15170	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7R78_RS15175	COG0083	homoserine kinase activity
H7R78_RS15185	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H7R78_RS15190	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H7R78_RS15205	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7R78_RS15215	COG0745	RESPONSE REGULATOR receiver
H7R78_RS15230	COG4988	ABC transporter
H7R78_RS15235	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H7R78_RS15255	COG1720	tRNA m6t6A37 methyltransferase activity
H7R78_RS15270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7R78_RS15275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7R78_RS15280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R78_RS15290	COG2190	(PTS) system
H7R78_RS15295	COG3038	cytochrome b561
H7R78_RS15305	COG0420	3'-5' exonuclease activity
H7R78_RS15310	COG1247	-acetyltransferase
H7R78_RS15315	COG2974	May be involved in recombination
H7R78_RS15330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7R78_RS15330	COG4651	solute:proton antiporter activity
H7R78_RS15365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R78_RS15370	COG1396	sequence-specific DNA binding
H7R78_RS15370	COG1917	Cupin 2, conserved barrel domain protein
H7R78_RS15375	COG1012	belongs to the aldehyde dehydrogenase family
H7R78_RS15390	COG0531	amino acid
H7R78_RS15395	COG0531	amino acid
H7R78_RS15405	COG1283	sodium-dependent phosphate transmembrane transporter activity
H7R78_RS15415	COG3384	dioxygenase
H7R78_RS15420	COG2205	protein histidine kinase activity
H7R78_RS15420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R78_RS15445	COG2205	protein histidine kinase activity
H7R78_RS15445	COG0784	Response regulator, receiver
H7R78_RS15455	COG1376	ErfK ybiS ycfS ynhG family protein
H7R78_RS15455	COG1388	LysM domain
H7R78_RS15470	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H7R78_RS15475	COG0791	NLP P60 protein
H7R78_RS15490	COG3118	belongs to the thioredoxin family
H7R78_RS15500	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7R78_RS15505	COG0788	formyltetrahydrofolate deformylase activity
H7R78_RS15530	COG0739	heme binding
H7R78_RS15530	COG0741	lytic transglycosylase activity
H7R78_RS15530	COG1196	nuclear chromosome segregation
H7R78_RS15540	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7R78_RS15545	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H7R78_RS15550	COG0673	inositol 2-dehydrogenase activity
H7R78_RS15585	COG3039	Transposase
H7R78_RS15595	COG1032	radical SAM domain protein
H7R78_RS15600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R78_RS15610	COG3706	GGDEF domain
H7R78_RS15615	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7R78_RS15620	COG0733	neurotransmitter:sodium symporter activity
H7R78_RS15650	COG0281	malic enzyme
H7R78_RS15655	COG2207	Transcriptional regulator
H7R78_RS15675	COG2233	PERMEase
H7R78_RS15680	COG0095	Lipoate-protein ligase
H7R78_RS15685	COG1115	amino acid carrier protein
H7R78_RS15690	COG0019	diaminopimelate decarboxylase activity
H7R78_RS15700	COG0678	peroxiredoxin activity
H7R78_RS15705	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H7R78_RS15715	COG1126	abc transporter atp-binding protein
H7R78_RS15720	COG0765	amino acid transport
H7R78_RS15725	COG4597	amino acid ABC transporter
H7R78_RS15730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R78_RS15740	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H7R78_RS15745	COG1131	(ABC) transporter
H7R78_RS15750	COG0545	Peptidyl-prolyl cis-trans isomerase
H7R78_RS15760	COG1940	carbohydrate kinase activity
H7R78_RS15770	COG4783	chaperone-mediated protein folding
H7R78_RS15780	COG5002	protein histidine kinase activity
H7R78_RS15785	COG0745	RESPONSE REGULATOR receiver
H7R78_RS15790	COG0346	lactoylglutathione lyase activity
H7R78_RS15795	COG3706	GGDEF domain
H7R78_RS15800	COG3284	Transcriptional regulator
H7R78_RS15815	COG0697	spore germination
H7R78_RS15820	COG0667	Aldo Keto reductase
H7R78_RS15835	COG3290	protein histidine kinase activity
H7R78_RS15845	COG1566	PFAM secretion protein HlyD family protein
H7R78_RS15870	COG0602	queuosine metabolic process
H7R78_RS15875	COG1328	CTP reductase activity
H7R78_RS15885	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7R78_RS15890	COG3115	cell septum assembly
H7R78_RS15895	COG1196	nuclear chromosome segregation
H7R78_RS15905	COG2860	membrane
H7R78_RS15915	COG3108	Peptidase M15
H7R78_RS15920	COG2989	Protein conserved in bacteria
H7R78_RS15935	COG0463	Glycosyl transferase, family 2
H7R78_RS15950	COG0366	Alpha amylase catalytic
H7R78_RS15985	COG3706	GGDEF domain
H7R78_RS15990	COG0037	tRNA processing
H7R78_RS15995	COG3590	peptidase
H7R78_RS16005	COG0488	(ABC) transporter
H7R78_RS16020	COG0531	amino acid
H7R78_RS16025	COG0814	amino acid
H7R78_RS16040	COG0825	malonyl-CoA metabolic process
H7R78_RS16045	COG0587	DNA-directed DNA polymerase activity
H7R78_RS16050	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H7R78_RS16055	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R78_RS16060	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R78_RS16065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7R78_RS16070	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R78_RS16085	COG0750	zinc metalloprotease
H7R78_RS16090	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H7R78_RS16095	COG0575	Belongs to the CDS family
H7R78_RS16100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7R78_RS16105	COG0233	cytoplasmic translational termination
H7R78_RS16110	COG0528	UMP kinase activity
H7R78_RS16115	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H7R78_RS16120	COG0052	Belongs to the universal ribosomal protein uS2 family
H7R78_RS16125	COG0024	Methionine aminopeptidase
H7R78_RS16130	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H7R78_RS16135	COG2171	N-acyltransferase activity
H7R78_RS16145	COG1263	PTS System
H7R78_RS16145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R78_RS16155	COG4580	involved in the transport of maltose and maltodextrins
H7R78_RS16170	COG0564	pseudouridine synthase activity
H7R78_RS16175	COG3098	single-species biofilm formation
H7R78_RS16200	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
H7R78_RS16210	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7R78_RS16210	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7R78_RS16225	COG1611	Belongs to the LOG family
H7R78_RS16230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7R78_RS16235	COG0473	3-isopropylmalate dehydrogenase activity
H7R78_RS16245	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H7R78_RS16260	COG0583	DNA-binding transcription factor activity
H7R78_RS16265	COG0840	transmembrane signaling receptor activity
H7R78_RS16270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7R78_RS16285	COG1477	protein flavinylation
H7R78_RS16290	COG2871	sodium ion transport
H7R78_RS16295	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R78_RS16300	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R78_RS16305	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R78_RS16310	COG1805	sodium ion transport
H7R78_RS16315	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R78_RS16320	COG0271	Belongs to the BolA IbaG family
H7R78_RS16325	COG2813	Specifically methylates the guanine in position
H7R78_RS16335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7R78_RS16345	COG2211	Major facilitator Superfamily
H7R78_RS16355	COG1666	GTP binding
H7R78_RS16360	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7R78_RS16370	COG0659	secondary active sulfate transmembrane transporter activity
H7R78_RS16375	COG5000	phosphorelay sensor kinase activity
H7R78_RS16375	COG5002	protein histidine kinase activity
H7R78_RS16385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R78_RS16390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R78_RS16445	COG0582	viral genome integration into host DNA
H7R78_RS16460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7R78_RS16470	COG1151	hydroxylamine reductase activity
H7R78_RS16475	COG0783	Belongs to the Dps family
H7R78_RS16500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7R78_RS16515	COG0300	oxidoreductase activity
H7R78_RS16525	COG0415	Belongs to the DNA photolyase family
H7R78_RS16530	COG0789	Transcriptional regulator
H7R78_RS16535	COG3272	Protein of unknown function (DUF1722)
H7R78_RS16560	COG1605	Chorismate mutase
H7R78_RS16560	COG0077	Prephenate dehydratase
H7R78_RS16590	COG2133	pyrroloquinoline quinone binding
H7R78_RS16600	COG1349	DNA-binding transcription factor activity
H7R78_RS16605	COG2084	Dehydrogenase
H7R78_RS16615	COG0235	Class ii aldolase
H7R78_RS16620	COG3622	Belongs to the hyi family
H7R78_RS16625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7R78_RS16630	COG2610	gluconate transmembrane transporter activity
H7R78_RS16650	COG3385	transposase activity
H7R78_RS16655	COG0300	oxidoreductase activity
H7R78_RS16680	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H7R78_RS16700	COG3813	Protein conserved in bacteria
H7R78_RS16710	COG0826	peptidase U32
H7R78_RS16715	COG1280	lysine exporter protein (LysE YggA)
H7R78_RS16725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7R78_RS16760	COG3275	phosphorelay sensor kinase activity
H7R78_RS16765	COG3279	Response regulator of the LytR AlgR family
H7R78_RS16770	COG1966	Carbon starvation protein
H7R78_RS16780	COG0114	fumarate hydratase activity
H7R78_RS16790	COG0506	proline dehydrogenase activity
H7R78_RS16790	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H7R78_RS16790	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H7R78_RS16795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7R78_RS16810	COG0737	Belongs to the 5'-nucleotidase family
H7R78_RS16830	COG2204	response regulator
H7R78_RS16835	COG0545	Peptidyl-prolyl cis-trans isomerase
H7R78_RS16845	COG2900	Belongs to the SlyX family
H7R78_RS16850	COG1047	Peptidyl-prolyl cis-trans
H7R78_RS16855	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H7R78_RS16865	COG0835	chemotaxis
H7R78_RS16865	COG0784	Response regulator, receiver
H7R78_RS16870	COG0429	hydrolase of the alpha beta-hydrolase fold
H7R78_RS16875	COG4251	negative regulation of phosphorylation
H7R78_RS16875	COG3706	GGDEF domain
H7R78_RS16875	COG5001	Diguanylate cyclase
H7R78_RS16875	COG2203	Gaf domain
H7R78_RS16880	COG3089	Belongs to the UPF0270 family
H7R78_RS16885	COG3954	Phosphoribulokinase
H7R78_RS16900	COG1765	OsmC-like protein
H7R78_RS16910	COG2226	methyltransferase
H7R78_RS16920	COG2202	Pas domain
H7R78_RS16920	COG2205	protein histidine kinase activity
H7R78_RS16925	COG2814	Major facilitator Superfamily
H7R78_RS16950	COG0748	coenzyme F420 binding
H7R78_RS16955	COG3721	Heme iron utilization protein
H7R78_RS16965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R78_RS16990	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H7R78_RS17000	COG0463	Glycosyl transferase, family 2
H7R78_RS17005	COG1196	nuclear chromosome segregation
H7R78_RS17005	COG0741	lytic transglycosylase activity
H7R78_RS17005	COG0739	heme binding
H7R78_RS17010	COG0488	(ABC) transporter
H7R78_RS17020	COG2252	PERMEase
H7R78_RS17025	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H7R78_RS17030	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7R78_RS17035	COG3178	'Phosphotransferase
H7R78_RS17040	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H7R78_RS17050	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7R78_RS17055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7R78_RS17060	COG2967	ApaG domain
H7R78_RS17065	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7R78_RS17075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7R78_RS17085	COG3314	Sporulation integral membrane protein YlbJ
H7R78_RS17090	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H7R78_RS17095	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H7R78_RS17100	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H7R78_RS17105	COG0142	geranyltranstransferase activity
H7R78_RS17110	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H7R78_RS17115	COG0330	HflC and HflK could
H7R78_RS17120	COG0330	HflC and HflK could
H7R78_RS17125	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7R78_RS17130	COG1923	regulation of RNA biosynthetic process
H7R78_RS17135	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H7R78_RS17140	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7R78_RS17150	COG0802	atpase or kinase
H7R78_RS17155	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H7R78_RS17155	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H7R78_RS17175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7R78_RS17180	COG2011	ABC-type metal ion transport system permease component
H7R78_RS17185	COG1464	Belongs to the NlpA lipoprotein family
H7R78_RS17205	COG2205	protein histidine kinase activity
H7R78_RS17205	COG0784	Response regulator, receiver
H7R78_RS17220	COG5002	protein histidine kinase activity
H7R78_RS17220	COG2198	Histidine kinase
H7R78_RS17220	COG0784	Response regulator, receiver
H7R78_RS17240	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H7R78_RS17255	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7R78_RS17260	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H7R78_RS17265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7R78_RS17270	COG2716	regulation of RNA biosynthetic process
H7R78_RS17275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7R78_RS17280	COG3013	Belongs to the UPF0304 family
H7R78_RS17290	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7R78_RS17295	COG0857	belongs to the CobB CobQ family
H7R78_RS17295	COG0280	phosphate acetyltransferase
H7R78_RS17300	COG0440	acetolactate synthase activity
H7R78_RS17305	COG0028	Belongs to the TPP enzyme family
H7R78_RS17320	COG0671	phosphoesterase, PA-phosphatase related
H7R78_RS17330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7R78_RS17335	COG0473	3-isopropylmalate dehydrogenase activity
H7R78_RS17340	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H7R78_RS17345	COG0066	3-isopropylmalate dehydratase activity
H7R78_RS17360	COG4143	(ABC) transporter
H7R78_RS17365	COG1178	ABC-type Fe3 transport system permease component
H7R78_RS17370	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H7R78_RS17380	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H7R78_RS17390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7R78_RS17420	COG0316	Belongs to the HesB IscA family
H7R78_RS17430	COG0038	chloride channel
H7R78_RS17435	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7R78_RS17450	COG0671	phosphoesterase, PA-phosphatase related
H7R78_RS17460	COG0583	DNA-binding transcription factor activity
H7R78_RS17465	COG2076	Multidrug Resistance protein
H7R78_RS17475	COG0346	lactoylglutathione lyase activity
H7R78_RS17480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7R78_RS17485	COG1643	Atp-dependent helicase
H7R78_RS17495	COG1489	DNA binding
H7R78_RS17500	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7R78_RS17505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7R78_RS17515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H7R78_RS17520	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7R78_RS17525	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7R78_RS17535	COG0842	Transport permease protein
H7R78_RS17540	COG1131	(ABC) transporter
H7R78_RS17555	COG0163	prenyltransferase activity
H7R78_RS17560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7R78_RS17565	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7R78_RS17580	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H7R78_RS17595	COG1136	(ABC) transporter
H7R78_RS17645	COG2801	Transposase and inactivated derivatives
H7R78_RS17650	COG0529	Catalyzes the synthesis of activated sulfate
H7R78_RS17655	COG3273	potassium ion transport
H7R78_RS17655	COG0471	metal ion transport
H7R78_RS17660	COG2895	sulfate adenylyltransferase (ATP) activity
H7R78_RS17665	COG0175	sulfate reduction
H7R78_RS17670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7R78_RS17670	COG1648	precorrin-2 dehydrogenase activity
H7R78_RS17675	COG0330	HflC and HflK could
H7R78_RS17680	COG1585	Membrane protein implicated in regulation of membrane protease activity
H7R78_RS17690	COG0673	inositol 2-dehydrogenase activity
H7R78_RS17700	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H7R78_RS17705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7R78_RS17710	COG3036	rescue of stalled ribosome
H7R78_RS17725	COG0138	bifunctional purine biosynthesis protein purh
H7R78_RS17760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7R78_RS17765	COG0358	DNA primase activity
H7R78_RS17770	COG1610	YqeY-like protein
H7R78_RS17775	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H7R78_RS17780	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H7R78_RS17785	COG3385	transposase activity
H7R78_RS17795	COG1388	LysM domain
H7R78_RS17795	COG4942	peptidase
H7R78_RS17800	COG1238	metal cluster binding
H7R78_RS17805	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7R78_RS17810	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H7R78_RS17815	COG0585	pseudouridine synthase activity
H7R78_RS17825	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H7R78_RS17830	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H7R78_RS17835	COG0148	phosphopyruvate hydratase activity
H7R78_RS17840	COG0504	CTP synthase activity
H7R78_RS17845	COG3956	TIGRFAM MazG family protein
H7R78_RS17850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7R78_RS17855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7R78_RS17865	COG4807	Protein conserved in bacteria
H7R78_RS17870	COG3023	N-Acetylmuramoyl-L-alanine amidase
H7R78_RS17875	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H7R78_RS17880	COG1381	Involved in DNA repair and RecF pathway recombination
H7R78_RS17890	COG0571	ribonuclease III activity
H7R78_RS17895	COG0681	Belongs to the peptidase S26 family
H7R78_RS17900	COG0481	GTPase activity
H7R78_RS17915	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
H7R78_RS17920	COG1595	DNA-templated transcription, initiation
H7R78_RS17925	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H7R78_RS17935	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H7R78_RS17945	COG0583	DNA-binding transcription factor activity
H7R78_RS17975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R78_RS17985	COG0126	phosphoglycerate kinase activity
H7R78_RS17990	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7R78_RS17995	COG1940	carbohydrate kinase activity
H7R78_RS18000	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H7R78_RS18010	COG4991	sh3 domain protein
H7R78_RS18015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7R78_RS18030	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H7R78_RS18035	COG1028	Short-chain dehydrogenase reductase Sdr
H7R78_RS18045	COG1505	serine-type exopeptidase activity
H7R78_RS18050	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7R78_RS18055	COG0765	amino acid transport
H7R78_RS18060	COG0765	amino acid transport
H7R78_RS18065	COG1126	abc transporter atp-binding protein
H7R78_RS18070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R78_RS18075	COG3174	membrane
H7R78_RS18080	COG0110	maltose O-acetyltransferase activity
H7R78_RS18110	COG1942	4-Oxalocrotonate Tautomerase
H7R78_RS18120	COG0583	DNA-binding transcription factor activity
H7R78_RS18125	COG0165	Argininosuccinate lyase
H7R78_RS18130	COG0137	argininosuccinate synthase activity
H7R78_RS18140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7R78_RS18145	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H7R78_RS18155	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H7R78_RS18160	COG5002	protein histidine kinase activity
H7R78_RS18160	COG5001	Diguanylate cyclase
H7R78_RS18160	COG3447	MASE1 domain protein
H7R78_RS18165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7R78_RS18200	COG0583	DNA-binding transcription factor activity
H7R78_RS18205	COG1380	Effector of murein hydrolase LrgA
H7R78_RS18210	COG1346	cytolysis
H7R78_RS18215	COG0527	aspartate kinase activity
H7R78_RS18215	COG0460	homoserine dehydrogenase
H7R78_RS18220	COG0626	cystathionine gamma-synthase activity
H7R78_RS18235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R78_RS18240	COG0814	amino acid
H7R78_RS18245	COG1218	3'(2'),5'-bisphosphate nucleotidase
H7R78_RS18250	COG0494	nUDIX hydrolase
H7R78_RS18255	COG1011	Hydrolase
H7R78_RS18260	COG1902	pentaerythritol trinitrate reductase activity
H7R78_RS18270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7R78_RS18285	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H7R78_RS18295	COG3156	type II secretion system protein K
H7R78_RS18305	COG4795	General secretion pathway protein
H7R78_RS18310	COG2165	general secretion pathway protein
H7R78_RS18320	COG2165	general secretion pathway protein
H7R78_RS18325	COG1459	type II secretion system
H7R78_RS18330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7R78_RS18340	COG3031	protein transport across the cell outer membrane
H7R78_RS18350	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H7R78_RS18355	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H7R78_RS18375	COG3133	Outer membrane lipoprotein
H7R78_RS18380	COG3025	triphosphatase activity
H7R78_RS18385	COG1392	Phosphate transport regulator
H7R78_RS18390	COG0306	phosphate transporter
H7R78_RS18395	COG0617	tRNA 3'-terminal CCA addition
H7R78_RS18400	COG3267	Type II secretory pathway component ExeA
H7R78_RS18400	COG3409	Peptidoglycan-binding domain 1 protein
H7R78_RS18410	COG1194	a g-specific adenine glycosylase
H7R78_RS18415	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H7R78_RS18430	COG3240	lipase activity
H7R78_RS18440	COG3009	Protein conserved in bacteria
H7R78_RS18445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7R78_RS18445	COG3008	intermembrane lipid transfer
H7R78_RS18450	COG2995	paraquat-inducible protein a
H7R78_RS18460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R78_RS18465	COG2203	Gaf domain
H7R78_RS18465	COG3706	GGDEF domain
H7R78_RS18465	COG4251	negative regulation of phosphorylation
H7R78_RS18465	COG5001	Diguanylate cyclase
H7R78_RS18470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7R78_RS18475	COG2813	Specifically methylates the guanine in position
H7R78_RS18480	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7R78_RS18485	COG0297	glycogen (starch) synthase activity
H7R78_RS18525	COG1757	Na H antiporter
H7R78_RS18530	COG0583	DNA-binding transcription factor activity
H7R78_RS18535	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H7R78_RS18540	COG3842	ATPase activity
H7R78_RS18545	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7R78_RS18550	COG1177	transmembrane transport
H7R78_RS18555	COG1012	belongs to the aldehyde dehydrogenase family
H7R78_RS18560	COG0109	protoheme IX farnesyltransferase activity
H7R78_RS18590	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H7R78_RS18600	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7R78_RS18600	COG1565	acr, cog1565
H7R78_RS18605	COG1444	tRNA N-acetyltransferase activity
H7R78_RS18625	COG1803	Methylglyoxal synthase
H7R78_RS18640	COG0252	asparaginase activity
H7R78_RS18660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R78_RS18660	COG1263	PTS System
H7R78_RS18665	COG0366	Alpha amylase catalytic
H7R78_RS18670	COG0110	maltose O-acetyltransferase activity
H7R78_RS18675	COG1522	sequence-specific DNA binding
H7R78_RS18705	COG3068	Protein conserved in bacteria
H7R78_RS18715	COG0739	heme binding
H7R78_RS18735	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H7R78_RS18740	COG1121	(ABC) transporter
H7R78_RS18745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7R78_RS18750	COG0583	DNA-binding transcription factor activity
H7R78_RS18760	COG1573	uracil-dna glycosylase
H7R78_RS18765	COG2962	Rard protein
H7R78_RS18770	COG2827	Endonuclease containing a URI domain
H7R78_RS18785	COG1842	Phage shock protein A
H7R78_RS18790	COG0204	Acyl-transferase
H7R78_RS18810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7R78_RS18820	COG0484	heat shock protein binding
H7R78_RS18885	COG1289	transmembrane transporter activity
H7R78_RS18890	COG1566	PFAM secretion protein HlyD family protein
H7R78_RS18905	COG1051	belongs to the nudix hydrolase family
H7R78_RS18910	COG3150	esterase
H7R78_RS18920	COG3151	Protein conserved in bacteria
H7R78_RS18925	COG0494	nUDIX hydrolase
H7R78_RS18930	COG1538	Outer membrane efflux protein
H7R78_RS18935	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H7R78_RS18935	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H7R78_RS18940	COG1560	Kdo2-lipid A biosynthetic process
H7R78_RS18955	COG2771	luxR family
H7R78_RS18960	COG3916	Acyl-homoserine-lactone synthase
H7R78_RS18970	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H7R78_RS18975	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R78_RS18975	COG2213	PTS system mannitol-specific
H7R78_RS18980	COG0246	Mannitol dehydrogenase
H7R78_RS18985	COG3722	fumarate hydratase activity
H7R78_RS18990	COG3263	regulation of cellular component size
H7R78_RS19010	COG1671	Belongs to the UPF0178 family
H7R78_RS19030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R78_RS19035	COG0513	Belongs to the DEAD box helicase family
H7R78_RS19055	COG3385	transposase activity
H7R78_RS19060	COG1575	Belongs to the MenA family. Type 1 subfamily
H7R78_RS19065	COG1169	isochorismate synthase
H7R78_RS19070	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H7R78_RS19075	COG0596	Alpha beta hydrolase
H7R78_RS19080	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H7R78_RS19090	COG0318	PFAM AMP-dependent synthetase and ligase
H7R78_RS19095	COG3291	Pkd domain containing protein
H7R78_RS19100	COG2949	membrane
H7R78_RS19105	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H7R78_RS19115	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H7R78_RS19145	COG2873	o-acetylhomoserine
H7R78_RS19155	COG1979	alcohol dehydrogenase
H7R78_RS19170	COG4221	oxidoreductase activity
H7R78_RS19190	COG1285	pathogenesis
H7R78_RS19205	COG1368	sulfuric ester hydrolase activity
H7R78_RS19210	COG1522	sequence-specific DNA binding
H7R78_RS19220	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H7R78_RS19230	COG1058	Belongs to the CinA family
H7R78_RS19230	COG1546	Belongs to the CinA family
H7R78_RS19235	COG1988	membrane-bound metal-dependent
H7R78_RS19250	COG0561	phosphatase activity
H7R78_RS19255	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H7R78_RS19265	COG1011	Hydrolase
H7R78_RS19280	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H7R78_RS19285	COG0019	diaminopimelate decarboxylase activity
H7R78_RS19295	COG1965	Belongs to the frataxin family
H7R78_RS19300	COG0400	carboxylic ester hydrolase activity
H7R78_RS19305	COG3072	Adenylate cyclase
H7R78_RS19310	COG0181	hydroxymethylbilane synthase activity
H7R78_RS19320	COG2959	enzyme of heme biosynthesis
H7R78_RS19325	COG3071	HemY protein
H7R78_RS19330	COG0312	modulator of DNA gyrase
H7R78_RS19335	COG3028	Belongs to the UPF0307 family
H7R78_RS19345	COG2926	Belongs to the UPF0265 family
H7R78_RS19380	COG1396	sequence-specific DNA binding
H7R78_RS19385	COG3135	benzoate transporter
H7R78_RS19415	COG3047	cAMP biosynthetic process
H7R78_RS19420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7R78_RS19425	COG2197	response regulator
H7R78_RS19455	COG5642	Protein of unknown function (DUF2384)
H7R78_RS19485	COG3328	transposase activity
H7R78_RS19490	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R78_RS19540	COG0457	Tetratricopeptide repeat
H7R78_RS19545	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H7R78_RS19550	COG1215	transferase activity, transferring glycosyl groups
H7R78_RS19555	COG0455	bacterial-type flagellum organization
H7R78_RS19580	COG5499	transcription regulator containing HTH domain
H7R78_RS19585	COG2916	Histone family protein nucleoid-structuring protein H-NS
H7R78_RS19595	COG3039	Transposase
H7R78_RS19620	COG1278	Cold shock
H7R78_RS19650	COG3706	GGDEF domain
H7R78_RS19655	COG0347	Belongs to the P(II) protein family
H7R78_RS19660	COG0004	ammonium transporteR
H7R78_RS19670	COG0346	lactoylglutathione lyase activity
H7R78_RS19685	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7R78_RS19690	COG1074	ATP-dependent DNA helicase activity
H7R78_RS19695	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H7R78_RS19700	COG2259	Doxx family
H7R78_RS19705	COG1741	Belongs to the pirin family
H7R78_RS19715	COG0583	DNA-binding transcription factor activity
H7R78_RS19740	COG1175	transmembrane transport
H7R78_RS19750	COG3842	ATPase activity
H7R78_RS19780	COG0456	acetyltransferase
H7R78_RS19785	COG0753	catalase activity
H7R78_RS19805	COG0494	nUDIX hydrolase
H7R78_RS19810	COG0628	permease
H7R78_RS19820	COG2957	Belongs to the agmatine deiminase family
H7R78_RS19835	COG2957	Belongs to the agmatine deiminase family
H7R78_RS19840	COG0583	DNA-binding transcription factor activity
H7R78_RS19855	COG1461	Dihydroxyacetone kinase
H7R78_RS19860	COG2376	Dihydroxyacetone kinase
H7R78_RS19865	COG2252	PERMEase
H7R78_RS19870	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H7R78_RS19905	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7R78_RS19910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7R78_RS19915	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7R78_RS19920	COG0049	tRNA binding
H7R78_RS19925	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H7R78_RS19930	COG2168	tRNA wobble position uridine thiolation
H7R78_RS19940	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H7R78_RS19945	COG0251	oxidation-reduction process
H7R78_RS19950	COG2964	Protein conserved in bacteria
H7R78_RS19955	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H7R78_RS19960	COG0085	RNA polymerase activity
H7R78_RS19965	COG0222	ribosome binding
H7R78_RS19970	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H7R78_RS19975	COG0081	regulation of translation
H7R78_RS19980	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H7R78_RS19985	COG0250	Participates in transcription elongation, termination and antitermination
H7R78_RS20000	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7R78_RS20025	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H7R78_RS20030	COG0569	domain protein
H7R78_RS20035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7R78_RS20040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7R78_RS20045	COG3005	denitrification pathway
H7R78_RS20050	COG0243	molybdopterin cofactor binding
H7R78_RS20085	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7R78_RS20095	COG2204	response regulator
H7R78_RS20105	COG2205	protein histidine kinase activity
H7R78_RS20125	COG0516	GMP reductase activity
H7R78_RS20125	COG0517	IMP dehydrogenase activity
H7R78_RS20135	COG1522	sequence-specific DNA binding
H7R78_RS20140	COG2502	aspartate--ammonia ligase
H7R78_RS20155	COG0583	DNA-binding transcription factor activity
H7R78_RS20160	COG0542	response to heat
H7R78_RS20170	COG0564	pseudouridine synthase activity
H7R78_RS20175	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R78_RS20180	COG3681	Belongs to the UPF0597 family
H7R78_RS20185	COG2964	Protein conserved in bacteria
H7R78_RS20190	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H7R78_RS20195	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H7R78_RS20200	COG1979	alcohol dehydrogenase
H7R78_RS20205	COG2207	Transcriptional regulator
H7R78_RS20210	COG3040	lipid binding
H7R78_RS20230	COG0583	DNA-binding transcription factor activity
H7R78_RS20250	COG0540	Belongs to the ATCase OTCase family
H7R78_RS20255	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
H7R78_RS20260	COG1438	arginine binding
H7R78_RS20265	COG1288	antiporter activity
H7R78_RS20270	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7R78_RS20310	COG3250	beta-galactosidase activity
H7R78_RS20315	COG1609	Transcriptional regulator
H7R78_RS20320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7R78_RS20330	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H7R78_RS20335	COG2017	converts alpha-aldose to the beta-anomer
H7R78_RS20340	COG0667	Aldo Keto reductase
H7R78_RS20345	COG1968	undecaprenyl-diphosphatase activity
H7R78_RS20350	COG3806	Anti-sigma factor
H7R78_RS20355	COG1595	DNA-templated transcription, initiation
H7R78_RS20375	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H7R78_RS20380	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H7R78_RS20385	COG0477	Major facilitator Superfamily
H7R78_RS20400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R78_RS20405	COG1131	(ABC) transporter
H7R78_RS20410	COG0842	Transport permease protein
H7R78_RS20415	COG0842	Transport permease protein
H7R78_RS20420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7R78_RS20430	COG2116	formate transmembrane transporter activity
H7R78_RS20435	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7R78_RS20435	COG1648	precorrin-2 dehydrogenase activity
H7R78_RS20440	COG2239	Acts as a magnesium transporter
H7R78_RS20445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7R78_RS20450	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H7R78_RS20460	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H7R78_RS20470	COG0514	ATP-dependent DNA helicase (RecQ)
H7R78_RS20475	COG2050	protein possibly involved in aromatic compounds catabolism
H7R78_RS20490	COG2258	MOSC domain
H7R78_RS20495	COG1177	transmembrane transport
H7R78_RS20500	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7R78_RS20505	COG3842	ATPase activity
H7R78_RS20525	COG0174	glutamine synthetase
H7R78_RS20545	COG3045	CreA protein
H7R78_RS20550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7R78_RS20555	COG0443	Heat shock 70 kDa protein
H7R78_RS20570	COG0366	Alpha amylase catalytic
H7R78_RS20585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7R78_RS20590	COG0745	RESPONSE REGULATOR receiver
H7R78_RS20600	COG2205	protein histidine kinase activity
H7R78_RS20610	COG0281	malic enzyme
H7R78_RS20615	COG0702	epimerase
H7R78_RS20625	COG0254	rRNA binding
H7R78_RS20630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7R78_RS20650	COG0129	dihydroxy-acid dehydratase activity
H7R78_RS20660	COG3978	acetolactate synthase activity
H7R78_RS20670	COG0606	chelatase, subunit chli
H7R78_RS20675	COG0204	Acyl-transferase
H7R78_RS20680	COG0204	Acyl-transferase
H7R78_RS20685	COG1683	Conserved Protein
H7R78_RS20695	COG1335	isochorismatase
H7R78_RS20705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7R78_RS20710	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7R78_RS20720	COG3084	Protein conserved in bacteria
H7R78_RS20725	COG4251	negative regulation of phosphorylation
H7R78_RS20725	COG2203	Gaf domain
H7R78_RS20725	COG3706	GGDEF domain
H7R78_RS20725	COG5001	Diguanylate cyclase
H7R78_RS20740	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H7R78_RS20745	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H7R78_RS20750	COG1561	YicC-like family, N-terminal region
H7R78_RS20760	COG1519	Transferase
H7R78_RS20765	COG0859	PFAM glycosyl transferase family 9
H7R78_RS20770	COG0463	Glycosyl transferase, family 2
H7R78_RS20775	COG0859	PFAM glycosyl transferase family 9
H7R78_RS20780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H7R78_RS20785	COG2990	Protein conserved in bacteria
H7R78_RS20790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H7R78_RS20800	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H7R78_RS20805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H7R78_RS20810	COG2003	Belongs to the UPF0758 family
H7R78_RS20815	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7R78_RS20820	COG0756	dUTP diphosphatase activity
H7R78_RS20825	COG1309	transcriptional regulator
H7R78_RS20835	COG0668	transmembrane transport
H7R78_RS20845	COG0166	Belongs to the GPI family
H7R78_RS20850	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7R78_RS20855	COG0583	DNA-binding transcription factor activity
H7R78_RS20865	COG1042	CoA-binding domain protein
H7R78_RS20865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7R78_RS20865	COG0045	succinate-CoA ligase (ADP-forming) activity
H7R78_RS20890	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
H7R78_RS20895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7R78_RS20900	COG1739	Uncharacterized protein family UPF0029
H7R78_RS20905	COG0006	proline dipeptidase activity
H7R78_RS20910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7R78_RS20915	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7R78_RS20915	COG1024	Enoyl-CoA hydratase
H7R78_RS20920	COG0183	Belongs to the thiolase family
H7R78_RS20960	COG0425	Belongs to the sulfur carrier protein TusA family
H7R78_RS20965	COG0251	oxidation-reduction process
H7R78_RS20985	COG2885	chlorophyll binding
H7R78_RS20995	COG1335	isochorismatase
H7R78_RS21000	COG2818	Glycosylase
H7R78_RS21005	COG0752	glycyl-tRNA synthetase alpha subunit
H7R78_RS21010	COG0751	glycine-tRNA ligase activity
H7R78_RS21025	COG5001	Diguanylate cyclase
H7R78_RS21025	COG4251	negative regulation of phosphorylation
H7R78_RS21025	COG3706	GGDEF domain
H7R78_RS21025	COG2203	Gaf domain
H7R78_RS21045	COG0814	amino acid
H7R78_RS21050	COG0814	amino acid
H7R78_RS21055	COG3033	Beta-eliminating lyase
H7R78_RS21065	COG0348	domain, Protein
H7R78_RS21075	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R78_RS21080	COG0426	domain, Protein
H7R78_RS21080	COG1773	rubredoxin
H7R78_RS21085	COG3604	Transcriptional regulator
H7R78_RS21090	COG1609	Transcriptional regulator
H7R78_RS21130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7R78_RS21150	COG2960	long-chain fatty acid transporting porin activity
H7R78_RS21160	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H7R78_RS21175	COG3118	belongs to the thioredoxin family
H7R78_RS21180	COG0513	Belongs to the DEAD box helicase family
H7R78_RS21185	COG0248	Ppx GppA phosphatase
H7R78_RS21195	COG0742	ribosomal rna small subunit methyltransferase
H7R78_RS21215	COG0084	hydrolase, TatD family'
H7R78_RS21220	COG0805	protein transport
H7R78_RS21225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7R78_RS21230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7R78_RS21235	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H7R78_RS21240	COG3165	ubiquinone biosynthetic process from chorismate
H7R78_RS21250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7R78_RS21255	COG0402	S-adenosylhomocysteine deaminase activity
H7R78_RS21300	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H7R78_RS21305	COG0848	biopolymer transport protein
H7R78_RS21310	COG0811	peptide transport
H7R78_RS21315	COG0811	peptide transport
H7R78_RS21325	COG2771	luxR family
H7R78_RS21330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7R78_RS21335	COG1349	DNA-binding transcription factor activity
H7R78_RS21340	COG0745	RESPONSE REGULATOR receiver
H7R78_RS21345	COG2205	protein histidine kinase activity
H7R78_RS21355	COG4452	Inner membrane protein CreD
H7R78_RS21360	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H7R78_RS21365	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H7R78_RS21370	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H7R78_RS21375	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H7R78_RS21380	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H7R78_RS21385	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7R78_RS21390	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7R78_RS21400	COG0356	it plays a direct role in the translocation of protons across the membrane
H7R78_RS21410	COG1475	DNA binding
H7R78_RS21415	COG1192	Involved in chromosome partitioning
H7R78_RS21420	COG0357	Ribosomal RNA small subunit methyltransferase G
H7R78_RS21425	COG0445	tRNA wobble uridine modification
H7R78_RS21430	COG0716	FMN binding
H7R78_RS21435	COG4774	siderophore transport
H7R78_RS21440	COG4615	Cyclic peptide transporter
H7R78_RS21445	COG1120	ATPase activity
H7R78_RS21450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7R78_RS21460	COG3550	peptidyl-serine autophosphorylation
H7R78_RS21485	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H7R78_RS21490	COG0706	membrane insertase activity
H7R78_RS21495	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H7R78_RS21500	COG0594	ribonuclease P activity
H7R78_RS21505	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H7R78_RS21510	COG1126	abc transporter atp-binding protein
H7R78_RS21540	COG2974	May be involved in recombination
H7R78_RS21630	COG1484	DNA-dependent DNA replication
H7R78_RS21635	COG4584	PFAM Integrase catalytic
H7R78_RS21820	COG0640	Transcriptional regulator
H7R78_RS21885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7R78_RS21900	COG1002	Type II restriction enzyme, methylase subunits
H7R78_RS21905	COG1061	Type III restriction enzyme res subunit
H7R78_RS21910	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H7R78_RS21925	COG3385	transposase activity
H7R78_RS21940	COG0840	transmembrane signaling receptor activity
H7R78_RS21960	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R78_RS21980	COG0038	chloride channel
H7R78_RS22090	COG0183	Belongs to the thiolase family
H7R78_RS22100	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7R78_RS22120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R78_RS22140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R78_RS22175	COG0625	glutathione transferase activity
H7R78_RS22180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R78_RS22190	COG0583	DNA-binding transcription factor activity
H7R78_RS22200	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R78_RS22225	COG3385	transposase activity
H7R78_RS22275	COG1192	Involved in chromosome partitioning
H7R78_RS22305	COG1525	nuclease
H7R78_RS22365	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R78_RS22385	COG1192	Involved in chromosome partitioning
H7R78_RS22395	COG3173	Aminoglycoside phosphotransferase
H7R78_RS22425	COG3041	Addiction module toxin RelE StbE family
H7R78_RS22480	COG5002	protein histidine kinase activity
H7R78_RS22480	COG2176	DNA-directed DNA polymerase activity
H7R78_RS22585	COG3385	transposase activity
H7R78_RS22615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R78_RS22620	COG0625	glutathione transferase activity
H7R78_RS22645	COG1192	Involved in chromosome partitioning
H7R78_RS22670	COG1192	Involved in chromosome partitioning