locus-tag	class	description
LEO73_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LEO73_RS00010	COG0592	DNA-directed DNA polymerase activity
LEO73_RS00030	COG2378	regulation of single-species biofilm formation
LEO73_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
LEO73_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
LEO73_RS00045	COG3977	Valine--pyruvate aminotransferase
LEO73_RS00060	COG2814	Major facilitator Superfamily
LEO73_RS00065	COG0745	RESPONSE REGULATOR receiver
LEO73_RS00070	COG2205	protein histidine kinase activity
LEO73_RS00095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEO73_RS00100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO73_RS00100	COG4191	Histidine kinase
LEO73_RS00105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO73_RS00110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO73_RS00115	COG1309	transcriptional regulator
LEO73_RS00150	COG2271	Major facilitator Superfamily
LEO73_RS00170	COG0561	phosphatase activity
LEO73_RS00175	COG2267	carboxylic ester hydrolase activity
LEO73_RS00185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LEO73_RS00190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LEO73_RS00195	COG1758	RNA polymerase activity
LEO73_RS00205	COG0859	PFAM glycosyl transferase family 9
LEO73_RS00210	COG3642	lipopolysaccharide core region biosynthetic process
LEO73_RS00250	COG0589	response to stress
LEO73_RS00255	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LEO73_RS00265	COG1528	Iron-storage protein
LEO73_RS00270	COG2081	HI0933 family
LEO73_RS00275	COG2223	nitrite transmembrane transporter activity
LEO73_RS00285	COG3275	phosphorelay sensor kinase activity
LEO73_RS00290	COG3279	Response regulator of the LytR AlgR family
LEO73_RS00295	COG2223	nitrite transmembrane transporter activity
LEO73_RS00300	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LEO73_RS00305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LEO73_RS00320	COG0583	DNA-binding transcription factor activity
LEO73_RS00330	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LEO73_RS00365	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LEO73_RS00370	COG2166	iron-sulfur cluster assembly
LEO73_RS00375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LEO73_RS00385	COG5001	Diguanylate cyclase
LEO73_RS00385	COG3300	MHYT domain
LEO73_RS00390	COG3245	cytochrome
LEO73_RS00395	COG1063	alcohol dehydrogenase
LEO73_RS00410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEO73_RS00425	COG3306	glycosyltransferase involved in LPS biosynthesis
LEO73_RS00445	COG4774	siderophore transport
LEO73_RS00450	COG4607	ABC-type enterochelin transport system periplasmic component
LEO73_RS00455	COG4604	ABC transporter, ATP-binding protein
LEO73_RS00460	COG4605	iron ion homeostasis
LEO73_RS00465	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEO73_RS00470	COG1132	(ABC) transporter
LEO73_RS00475	COG2375	cellular response to nickel ion
LEO73_RS00475	COG1132	(ABC) transporter
LEO73_RS00485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LEO73_RS00495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LEO73_RS00505	COG0076	glutamate decarboxylase activity
LEO73_RS00510	COG1561	YicC-like family, N-terminal region
LEO73_RS00515	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LEO73_RS00520	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LEO73_RS00530	COG0789	Transcriptional regulator
LEO73_RS00535	COG2203	Gaf domain
LEO73_RS00535	COG3706	GGDEF domain
LEO73_RS00535	COG4251	negative regulation of phosphorylation
LEO73_RS00535	COG5001	Diguanylate cyclase
LEO73_RS00540	COG3084	Protein conserved in bacteria
LEO73_RS00550	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LEO73_RS00555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LEO73_RS00560	COG3639	organic phosphonate transmembrane transporter activity
LEO73_RS00565	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LEO73_RS00570	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LEO73_RS00580	COG1335	isochorismatase
LEO73_RS00590	COG1683	Conserved Protein
LEO73_RS00595	COG0204	Acyl-transferase
LEO73_RS00600	COG0204	Acyl-transferase
LEO73_RS00605	COG0606	chelatase, subunit chli
LEO73_RS00615	COG3978	acetolactate synthase activity
LEO73_RS00625	COG0129	dihydroxy-acid dehydratase activity
LEO73_RS00655	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LEO73_RS00660	COG0254	rRNA binding
LEO73_RS00665	COG0702	epimerase
LEO73_RS00670	COG0281	malic enzyme
LEO73_RS00680	COG2205	protein histidine kinase activity
LEO73_RS00685	COG0745	RESPONSE REGULATOR receiver
LEO73_RS00690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LEO73_RS00725	COG4310	Domain of unknown function (DUF2172)
LEO73_RS00745	COG2089	acid synthase
LEO73_RS00755	COG1083	cytidylyl-transferase
LEO73_RS00770	COG1028	Short-chain dehydrogenase reductase Sdr
LEO73_RS00775	COG0318	PFAM AMP-dependent synthetase and ligase
LEO73_RS00790	COG1215	transferase activity, transferring glycosyl groups
LEO73_RS00795	COG1442	glycosyl transferase family 8
LEO73_RS00835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LEO73_RS00845	COG4106	trans-aconitate 2-methyltransferase activity
LEO73_RS00860	COG0529	Catalyzes the synthesis of activated sulfate
LEO73_RS00870	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LEO73_RS00875	COG0574	Belongs to the PEP-utilizing enzyme family
LEO73_RS00875	COG3848	Pyruvate phosphate dikinase
LEO73_RS00880	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LEO73_RS00885	COG1213	nucleotidyl transferase
LEO73_RS00890	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LEO73_RS00895	COG1086	Polysaccharide biosynthesis protein
LEO73_RS00900	COG0366	Alpha amylase catalytic
LEO73_RS00910	COG3187	Heat shock protein
LEO73_RS00915	COG0443	Heat shock 70 kDa protein
LEO73_RS00920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LEO73_RS00925	COG3045	CreA protein
LEO73_RS00945	COG0174	glutamine synthetase
LEO73_RS00965	COG3842	ATPase activity
LEO73_RS00970	COG1176	ABC-type spermidine putrescine transport system, permease component I
LEO73_RS00975	COG1177	transmembrane transport
LEO73_RS00980	COG2258	MOSC domain
LEO73_RS00995	COG2050	protein possibly involved in aromatic compounds catabolism
LEO73_RS01000	COG0514	ATP-dependent DNA helicase (RecQ)
LEO73_RS01010	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LEO73_RS01020	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LEO73_RS01025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LEO73_RS01035	COG2239	Acts as a magnesium transporter
LEO73_RS01040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LEO73_RS01040	COG1648	precorrin-2 dehydrogenase activity
LEO73_RS01045	COG2116	formate transmembrane transporter activity
LEO73_RS01055	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LEO73_RS01065	COG0477	Major facilitator Superfamily
LEO73_RS01070	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LEO73_RS01075	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LEO73_RS01095	COG1595	DNA-templated transcription, initiation
LEO73_RS01100	COG3806	Anti-sigma factor
LEO73_RS01105	COG1968	undecaprenyl-diphosphatase activity
LEO73_RS01110	COG0667	Aldo Keto reductase
LEO73_RS01115	COG2017	converts alpha-aldose to the beta-anomer
LEO73_RS01120	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LEO73_RS01130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LEO73_RS01135	COG1609	Transcriptional regulator
LEO73_RS01140	COG3250	beta-galactosidase activity
LEO73_RS01190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LEO73_RS01195	COG1288	antiporter activity
LEO73_RS01200	COG1438	arginine binding
LEO73_RS01205	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LEO73_RS01210	COG0540	Belongs to the ATCase OTCase family
LEO73_RS01230	COG0688	phosphatidylethanolamine metabolic process
LEO73_RS01250	COG2207	Transcriptional regulator
LEO73_RS01255	COG1979	alcohol dehydrogenase
LEO73_RS01260	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LEO73_RS01265	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LEO73_RS01275	COG3681	Belongs to the UPF0597 family
LEO73_RS01285	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO73_RS01290	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LEO73_RS01295	COG0564	pseudouridine synthase activity
LEO73_RS01305	COG0542	response to heat
LEO73_RS01310	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LEO73_RS01315	COG2502	aspartate--ammonia ligase
LEO73_RS01320	COG1522	sequence-specific DNA binding
LEO73_RS01330	COG5413	integral membrane protein
LEO73_RS01335	COG0617	tRNA 3'-terminal CCA addition
LEO73_RS01335	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LEO73_RS01335	COG3620	sequence-specific DNA binding
LEO73_RS01340	COG1028	Short-chain dehydrogenase reductase Sdr
LEO73_RS01355	COG2205	protein histidine kinase activity
LEO73_RS01365	COG2204	response regulator
LEO73_RS01380	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LEO73_RS01410	COG0243	molybdopterin cofactor binding
LEO73_RS01415	COG3005	denitrification pathway
LEO73_RS01420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LEO73_RS01440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LEO73_RS01445	COG0569	domain protein
LEO73_RS01450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LEO73_RS01475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LEO73_RS01490	COG0250	Participates in transcription elongation, termination and antitermination
LEO73_RS01495	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LEO73_RS01500	COG0081	regulation of translation
LEO73_RS01505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LEO73_RS01510	COG0222	ribosome binding
LEO73_RS01515	COG0085	RNA polymerase activity
LEO73_RS01520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LEO73_RS01525	COG2964	Protein conserved in bacteria
LEO73_RS01530	COG0251	oxidation-reduction process
LEO73_RS01540	COG2923	Belongs to the DsrF TusC family
LEO73_RS01545	COG2168	tRNA wobble position uridine thiolation
LEO73_RS01550	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LEO73_RS01555	COG0049	tRNA binding
LEO73_RS01560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LEO73_RS01565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LEO73_RS01570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LEO73_RS01605	COG2252	PERMEase
LEO73_RS01610	COG2376	Dihydroxyacetone kinase
LEO73_RS01615	COG1461	Dihydroxyacetone kinase
LEO73_RS01630	COG3284	Transcriptional regulator
LEO73_RS01635	COG0583	DNA-binding transcription factor activity
LEO73_RS01640	COG2957	Belongs to the agmatine deiminase family
LEO73_RS01660	COG0628	permease
LEO73_RS01665	COG0671	phosphoesterase, PA-phosphatase related
LEO73_RS01690	COG1247	-acetyltransferase
LEO73_RS01710	COG3706	GGDEF domain
LEO73_RS01720	COG3842	ATPase activity
LEO73_RS01730	COG1175	transmembrane transport
LEO73_RS01755	COG0583	DNA-binding transcription factor activity
LEO73_RS01765	COG1741	Belongs to the pirin family
LEO73_RS01770	COG2259	Doxx family
LEO73_RS01775	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LEO73_RS01780	COG1074	ATP-dependent DNA helicase activity
LEO73_RS01785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LEO73_RS01795	COG0583	DNA-binding transcription factor activity
LEO73_RS01805	COG0346	lactoylglutathione lyase activity
LEO73_RS01850	COG4251	negative regulation of phosphorylation
LEO73_RS01850	COG2203	Gaf domain
LEO73_RS01850	COG3706	GGDEF domain
LEO73_RS01850	COG5001	Diguanylate cyclase
LEO73_RS01855	COG4771	TonB-dependent receptor
LEO73_RS01885	COG2197	response regulator
LEO73_RS01890	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LEO73_RS01900	COG3047	cAMP biosynthetic process
LEO73_RS01905	COG0840	transmembrane signaling receptor activity
LEO73_RS01930	COG3135	benzoate transporter
LEO73_RS01935	COG1396	sequence-specific DNA binding
LEO73_RS01965	COG2926	Belongs to the UPF0265 family
LEO73_RS01975	COG3028	Belongs to the UPF0307 family
LEO73_RS01980	COG0312	modulator of DNA gyrase
LEO73_RS01985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LEO73_RS01990	COG5007	Belongs to the BolA IbaG family
LEO73_RS02000	COG2854	intermembrane phospholipid transfer
LEO73_RS02005	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LEO73_RS02010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LEO73_RS02015	COG1127	ABC transporter
LEO73_RS02020	COG0517	IMP dehydrogenase activity
LEO73_RS02020	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LEO73_RS02025	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LEO73_RS02030	COG3117	lipopolysaccharide transmembrane transporter activity
LEO73_RS02035	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LEO73_RS02040	COG1137	ATPase activity
LEO73_RS02045	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LEO73_RS02055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO73_RS02060	COG1660	Displays ATPase and GTPase activities
LEO73_RS02065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO73_RS02070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO73_RS02070	COG3711	transcriptional antiterminator
LEO73_RS02085	COG3964	amidohydrolase
LEO73_RS02115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEO73_RS02120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEO73_RS02130	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LEO73_RS02135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LEO73_RS02140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LEO73_RS02145	COG0723	plastoquinol--plastocyanin reductase activity
LEO73_RS02150	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LEO73_RS02155	COG2857	Cytochrome c1
LEO73_RS02160	COG0625	glutathione transferase activity
LEO73_RS02165	COG2969	positive regulation of protein catabolic process
LEO73_RS02170	COG2823	Periplasmic or secreted lipoprotein
LEO73_RS02175	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LEO73_RS02180	COG0792	nuclease activity
LEO73_RS02185	COG3107	peptidoglycan biosynthetic process
LEO73_RS02190	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LEO73_RS02200	COG2001	Belongs to the MraZ family
LEO73_RS02205	COG0275	rRNA processing
LEO73_RS02210	COG3116	cell division
LEO73_RS02215	COG0768	penicillin binding
LEO73_RS02225	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LEO73_RS02230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LEO73_RS02235	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LEO73_RS02240	COG0772	Belongs to the SEDS family
LEO73_RS02245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LEO73_RS02250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LEO73_RS02255	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LEO73_RS02260	COG0849	cell division
LEO73_RS02265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LEO73_RS02270	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LEO73_RS02280	COG0653	protein targeting
LEO73_RS02290	COG0494	nUDIX hydrolase
LEO73_RS02295	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LEO73_RS02300	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LEO73_RS02315	COG1459	type II secretion system
LEO73_RS02320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LEO73_RS02345	COG2186	Transcriptional regulator
LEO73_RS02350	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LEO73_RS02355	COG0508	dehydrogenase complex catalyzes the overall conversion of
LEO73_RS02360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEO73_RS02370	COG0840	transmembrane signaling receptor activity
LEO73_RS02375	COG0840	transmembrane signaling receptor activity
LEO73_RS02380	COG1752	Esterase of the alpha-beta hydrolase superfamily
LEO73_RS02385	COG1049	propionate catabolic process, 2-methylcitrate cycle
LEO73_RS02390	COG2200	EAL domain
LEO73_RS02400	COG1280	lysine exporter protein (LysE YggA)
LEO73_RS02410	COG0523	cobalamin synthesis protein
LEO73_RS02415	COG0477	Major facilitator Superfamily
LEO73_RS02430	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LEO73_RS02435	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LEO73_RS02470	COG3314	Sporulation integral membrane protein YlbJ
LEO73_RS02475	COG0784	Response regulator, receiver
LEO73_RS02475	COG0835	chemotaxis
LEO73_RS02485	COG1444	tRNA N-acetyltransferase activity
LEO73_RS02510	COG1803	Methylglyoxal synthase
LEO73_RS02525	COG0252	asparaginase activity
LEO73_RS02540	COG1609	Transcriptional regulator
LEO73_RS02545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO73_RS02545	COG1263	PTS System
LEO73_RS02550	COG0366	Alpha amylase catalytic
LEO73_RS02555	COG0110	maltose O-acetyltransferase activity
LEO73_RS02580	COG1012	belongs to the aldehyde dehydrogenase family
LEO73_RS02585	COG1177	transmembrane transport
LEO73_RS02590	COG1176	ABC-type spermidine putrescine transport system, permease component I
LEO73_RS02595	COG3842	ATPase activity
LEO73_RS02600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LEO73_RS02605	COG0583	DNA-binding transcription factor activity
LEO73_RS02610	COG1757	Na H antiporter
LEO73_RS02650	COG0297	glycogen (starch) synthase activity
LEO73_RS02655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LEO73_RS02660	COG2813	Specifically methylates the guanine in position
LEO73_RS02665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LEO73_RS02670	COG4251	negative regulation of phosphorylation
LEO73_RS02670	COG2203	Gaf domain
LEO73_RS02670	COG5001	Diguanylate cyclase
LEO73_RS02670	COG3706	GGDEF domain
LEO73_RS02680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO73_RS02690	COG2995	paraquat-inducible protein a
LEO73_RS02695	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LEO73_RS02695	COG3008	intermembrane lipid transfer
LEO73_RS02700	COG3009	Protein conserved in bacteria
LEO73_RS02715	COG3240	lipase activity
LEO73_RS02720	COG3111	PFAM Bacterial OB fold (BOF) protein
LEO73_RS02730	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LEO73_RS02735	COG1194	a g-specific adenine glycosylase
LEO73_RS02745	COG3267	Type II secretory pathway component ExeA
LEO73_RS02745	COG3409	Peptidoglycan-binding domain 1 protein
LEO73_RS02750	COG0617	tRNA 3'-terminal CCA addition
LEO73_RS02765	COG1346	cytolysis
LEO73_RS02770	COG1380	Effector of murein hydrolase LrgA
LEO73_RS02775	COG0583	DNA-binding transcription factor activity
LEO73_RS02805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LEO73_RS02810	COG0306	phosphate transporter
LEO73_RS02815	COG1392	Phosphate transport regulator
LEO73_RS02830	COG1560	Kdo2-lipid A biosynthetic process
LEO73_RS02835	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LEO73_RS02835	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LEO73_RS02840	COG1538	Outer membrane efflux protein
LEO73_RS02845	COG0494	nUDIX hydrolase
LEO73_RS02850	COG3151	Protein conserved in bacteria
LEO73_RS02860	COG3150	esterase
LEO73_RS02865	COG1051	belongs to the nudix hydrolase family
LEO73_RS02880	COG1566	PFAM secretion protein HlyD family protein
LEO73_RS02885	COG1289	transmembrane transporter activity
LEO73_RS02900	COG0583	DNA-binding transcription factor activity
LEO73_RS02910	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LEO73_RS02960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LEO73_RS02985	COG0204	Acyl-transferase
LEO73_RS02990	COG1842	Phage shock protein A
LEO73_RS03005	COG2827	Endonuclease containing a URI domain
LEO73_RS03015	COG2962	Rard protein
LEO73_RS03020	COG1573	uracil-dna glycosylase
LEO73_RS03025	COG0697	spore germination
LEO73_RS03030	COG0583	DNA-binding transcription factor activity
LEO73_RS03035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LEO73_RS03040	COG1121	(ABC) transporter
LEO73_RS03045	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LEO73_RS03065	COG0739	heme binding
LEO73_RS03075	COG3068	Protein conserved in bacteria
LEO73_RS03095	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LEO73_RS03100	COG1546	Belongs to the CinA family
LEO73_RS03105	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LEO73_RS03115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LEO73_RS03120	COG0527	aspartate kinase activity
LEO73_RS03125	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LEO73_RS03160	COG1686	Belongs to the peptidase S11 family
LEO73_RS03165	COG0586	Pfam SNARE associated Golgi protein
LEO73_RS03170	COG1253	flavin adenine dinucleotide binding
LEO73_RS03175	COG0525	valine-tRNA ligase activity
LEO73_RS03180	COG2927	DNA polymerase III (CHI subunit)
LEO73_RS03185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LEO73_RS03190	COG0795	lipopolysaccharide-transporting ATPase activity
LEO73_RS03195	COG0795	lipopolysaccharide-transporting ATPase activity
LEO73_RS03210	COG0004	ammonium transporteR
LEO73_RS03215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LEO73_RS03230	COG2165	general secretion pathway protein
LEO73_RS03235	COG0084	hydrolase, TatD family'
LEO73_RS03240	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEO73_RS03250	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LEO73_RS03255	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LEO73_RS03260	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LEO73_RS03265	COG0813	purine-nucleoside phosphorylase activity
LEO73_RS03270	COG5002	protein histidine kinase activity
LEO73_RS03270	COG3447	MASE1 domain protein
LEO73_RS03270	COG5001	Diguanylate cyclase
LEO73_RS03280	COG0560	Phosphoserine phosphatase
LEO73_RS03315	COG0776	regulation of translation
LEO73_RS03330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LEO73_RS03335	COG0735	belongs to the Fur family
LEO73_RS03360	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LEO73_RS03365	COG0513	Belongs to the DEAD box helicase family
LEO73_RS03370	COG3022	response to hydroperoxide
LEO73_RS03385	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LEO73_RS03390	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LEO73_RS03395	COG0762	integral membrane protein
LEO73_RS03400	COG1872	DUF167
LEO73_RS03415	COG4166	transmembrane transport
LEO73_RS03425	COG0110	maltose O-acetyltransferase activity
LEO73_RS03435	COG1024	Enoyl-CoA hydratase
LEO73_RS03450	COG4221	oxidoreductase activity
LEO73_RS03455	COG0442	prolyl-tRNA aminoacylation
LEO73_RS03460	COG0840	transmembrane signaling receptor activity
LEO73_RS03465	COG0632	four-way junction helicase activity
LEO73_RS03470	COG2255	four-way junction helicase activity
LEO73_RS03475	COG1271	oxidase subunit
LEO73_RS03480	COG1294	oxidase, subunit
LEO73_RS03485	COG4890	Cyd operon protein YbgT
LEO73_RS03490	COG3790	cyd operon protein YbgE
LEO73_RS03495	COG0824	Thioesterase
LEO73_RS03500	COG0811	peptide transport
LEO73_RS03515	COG0823	Involved in the tonB-independent uptake of proteins
LEO73_RS03520	COG2885	chlorophyll binding
LEO73_RS03525	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LEO73_RS03600	COG0840	transmembrane signaling receptor activity
LEO73_RS03605	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LEO73_RS03610	COG0676	glucose-6-phosphate 1-epimerase activity
LEO73_RS03615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LEO73_RS03620	COG1640	4-alpha-glucanotransferase
LEO73_RS03625	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LEO73_RS03645	COG1051	belongs to the nudix hydrolase family
LEO73_RS03650	COG2130	NADP-dependent
LEO73_RS03655	COG1846	Transcriptional regulator
LEO73_RS03685	COG0561	phosphatase activity
LEO73_RS03700	COG0733	neurotransmitter:sodium symporter activity
LEO73_RS03710	COG0733	neurotransmitter:sodium symporter activity
LEO73_RS03735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LEO73_RS03750	COG1794	racemase activity, acting on amino acids and derivatives
LEO73_RS03765	COG2731	YhcH YjgK YiaL family protein
LEO73_RS03775	COG0668	transmembrane transport
LEO73_RS03785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LEO73_RS03825	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LEO73_RS03835	COG0488	(ABC) transporter
LEO73_RS03840	COG0517	IMP dehydrogenase activity
LEO73_RS03840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LEO73_RS03845	COG1585	Membrane protein implicated in regulation of membrane protease activity
LEO73_RS03850	COG0330	HflC and HflK could
LEO73_RS03855	COG1648	precorrin-2 dehydrogenase activity
LEO73_RS03855	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LEO73_RS03860	COG0175	sulfate reduction
LEO73_RS03865	COG2895	sulfate adenylyltransferase (ATP) activity
LEO73_RS03875	COG0529	Catalyzes the synthesis of activated sulfate
LEO73_RS03900	COG0840	transmembrane signaling receptor activity
LEO73_RS03920	COG1136	(ABC) transporter
LEO73_RS03935	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LEO73_RS03950	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LEO73_RS03955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LEO73_RS03960	COG0163	prenyltransferase activity
LEO73_RS03975	COG1131	(ABC) transporter
LEO73_RS03980	COG0842	Transport permease protein
LEO73_RS03985	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
LEO73_RS03990	COG1924	4 iron, 4 sulfur cluster binding
LEO73_RS04010	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LEO73_RS04015	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LEO73_RS04030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LEO73_RS04035	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LEO73_RS04040	COG1489	DNA binding
LEO73_RS04050	COG1643	Atp-dependent helicase
LEO73_RS04055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LEO73_RS04060	COG0346	lactoylglutathione lyase activity
LEO73_RS04070	COG2076	Multidrug Resistance protein
LEO73_RS04080	COG0784	Response regulator, receiver
LEO73_RS04080	COG3437	response regulator, receiver
LEO73_RS04090	COG0671	phosphoesterase, PA-phosphatase related
LEO73_RS04105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LEO73_RS04110	COG0038	chloride channel
LEO73_RS04120	COG0316	Belongs to the HesB IscA family
LEO73_RS04150	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LEO73_RS04165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO73_RS04195	COG0745	RESPONSE REGULATOR receiver
LEO73_RS04200	COG3104	oligopeptide transport
LEO73_RS04205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LEO73_RS04210	COG1555	photosystem II stabilization
LEO73_RS04215	COG1218	3'(2'),5'-bisphosphate nucleotidase
LEO73_RS04220	COG2350	Protein conserved in bacteria
LEO73_RS04225	COG2917	probably involved in intracellular septation
LEO73_RS04230	COG0076	glutamate decarboxylase activity
LEO73_RS04235	COG1272	protein, Hemolysin III
LEO73_RS04240	COG2985	domain, Protein
LEO73_RS04240	COG0569	domain protein
LEO73_RS04250	COG0564	pseudouridine synthase activity
LEO73_RS04255	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LEO73_RS04290	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LEO73_RS04300	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LEO73_RS04310	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LEO73_RS04320	COG4143	(ABC) transporter
LEO73_RS04335	COG0066	3-isopropylmalate dehydratase activity
LEO73_RS04340	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LEO73_RS04345	COG0473	3-isopropylmalate dehydrogenase activity
LEO73_RS04350	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LEO73_RS04360	COG0671	phosphoesterase, PA-phosphatase related
LEO73_RS04375	COG0028	Belongs to the TPP enzyme family
LEO73_RS04380	COG0440	acetolactate synthase activity
LEO73_RS04385	COG0280	phosphate acetyltransferase
LEO73_RS04385	COG0857	belongs to the CobB CobQ family
LEO73_RS04390	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LEO73_RS04400	COG3013	Belongs to the UPF0304 family
LEO73_RS04405	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LEO73_RS04410	COG2716	regulation of RNA biosynthetic process
LEO73_RS04420	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LEO73_RS04425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LEO73_RS04440	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LEO73_RS04460	COG5002	protein histidine kinase activity
LEO73_RS04460	COG2198	Histidine kinase
LEO73_RS04460	COG0784	Response regulator, receiver
LEO73_RS04485	COG0840	transmembrane signaling receptor activity
LEO73_RS04495	COG1464	Belongs to the NlpA lipoprotein family
LEO73_RS04500	COG2011	ABC-type metal ion transport system permease component
LEO73_RS04505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LEO73_RS04520	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LEO73_RS04525	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LEO73_RS04525	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LEO73_RS04530	COG0802	atpase or kinase
LEO73_RS04540	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LEO73_RS04545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LEO73_RS04550	COG1923	regulation of RNA biosynthetic process
LEO73_RS04555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LEO73_RS04560	COG0330	HflC and HflK could
LEO73_RS04565	COG0330	HflC and HflK could
LEO73_RS04570	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
LEO73_RS04575	COG0142	geranyltranstransferase activity
LEO73_RS04580	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LEO73_RS04585	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LEO73_RS04590	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LEO73_RS04595	COG3314	Sporulation integral membrane protein YlbJ
LEO73_RS04600	COG0318	PFAM AMP-dependent synthetase and ligase
LEO73_RS04615	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEO73_RS04620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LEO73_RS04630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LEO73_RS04635	COG2967	ApaG domain
LEO73_RS04640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LEO73_RS04645	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LEO73_RS04655	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LEO73_RS04660	COG3178	'Phosphotransferase
LEO73_RS04665	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LEO73_RS04670	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LEO73_RS04675	COG2252	PERMEase
LEO73_RS04685	COG0488	(ABC) transporter
LEO73_RS04700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LEO73_RS04705	COG0741	lytic transglycosylase activity
LEO73_RS04730	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LEO73_RS04735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEO73_RS04745	COG3721	Heme iron utilization protein
LEO73_RS04750	COG0748	coenzyme F420 binding
LEO73_RS04770	COG4771	TonB-dependent receptor
LEO73_RS04775	COG2814	Major facilitator Superfamily
LEO73_RS04785	COG3655	Transcriptional regulator
LEO73_RS04795	COG2202	Pas domain
LEO73_RS04795	COG2205	protein histidine kinase activity
LEO73_RS04810	COG3397	chitin binding
LEO73_RS04825	COG1765	OsmC-like protein
LEO73_RS04840	COG3954	Phosphoribulokinase
LEO73_RS04845	COG2076	Multidrug Resistance protein
LEO73_RS04850	COG2076	Multidrug Resistance protein
LEO73_RS04855	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LEO73_RS04860	COG0726	polysaccharide deacetylase
LEO73_RS04865	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LEO73_RS04865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEO73_RS04870	COG0463	Glycosyl transferase, family 2
LEO73_RS04875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LEO73_RS04885	COG3089	Belongs to the UPF0270 family
LEO73_RS04890	COG0429	hydrolase of the alpha beta-hydrolase fold
LEO73_RS04895	COG0784	Response regulator, receiver
LEO73_RS04895	COG0835	chemotaxis
LEO73_RS04905	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LEO73_RS04910	COG1047	Peptidyl-prolyl cis-trans
LEO73_RS04915	COG2900	Belongs to the SlyX family
LEO73_RS04925	COG0545	Peptidyl-prolyl cis-trans isomerase
LEO73_RS04930	COG2204	response regulator
LEO73_RS04950	COG0737	Belongs to the 5'-nucleotidase family
LEO73_RS04955	COG2200	EAL domain
LEO73_RS04970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LEO73_RS04975	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO73_RS04980	COG0826	peptidase U32
LEO73_RS04985	COG2199	diguanylate cyclase activity
LEO73_RS04985	COG2203	Gaf domain
LEO73_RS04985	COG2200	EAL domain
LEO73_RS05010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LEO73_RS05015	COG2201	protein-glutamate methylesterase activity
LEO73_RS05020	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LEO73_RS05030	COG0840	transmembrane signaling receptor activity
LEO73_RS05035	COG0835	chemotaxis
LEO73_RS05045	COG2198	Histidine kinase
LEO73_RS05045	COG0643	Histidine kinase
LEO73_RS05055	COG0745	RESPONSE REGULATOR receiver
LEO73_RS05065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LEO73_RS05075	COG1280	lysine exporter protein (LysE YggA)
LEO73_RS05080	COG0826	peptidase U32
LEO73_RS05110	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LEO73_RS05135	COG0300	oxidoreductase activity
LEO73_RS05145	COG0840	transmembrane signaling receptor activity
LEO73_RS05155	COG2610	gluconate transmembrane transporter activity
LEO73_RS05160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEO73_RS05165	COG3622	Belongs to the hyi family
LEO73_RS05170	COG0235	Class ii aldolase
LEO73_RS05180	COG2084	Dehydrogenase
LEO73_RS05185	COG1349	DNA-binding transcription factor activity
LEO73_RS05210	COG0077	Prephenate dehydratase
LEO73_RS05210	COG1605	Chorismate mutase
LEO73_RS05240	COG3272	Protein of unknown function (DUF1722)
LEO73_RS05245	COG0789	Transcriptional regulator
LEO73_RS05250	COG0415	Belongs to the DNA photolyase family
LEO73_RS05260	COG4221	oxidoreductase activity
LEO73_RS05275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LEO73_RS05300	COG0783	Belongs to the Dps family
LEO73_RS05305	COG1151	hydroxylamine reductase activity
LEO73_RS05315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LEO73_RS05320	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LEO73_RS05320	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LEO73_RS05330	COG2771	luxR family
LEO73_RS05390	COG0693	protein deglycase activity
LEO73_RS05395	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LEO73_RS05400	COG1666	GTP binding
LEO73_RS05405	COG3248	Nucleoside-binding outer membrane protein
LEO73_RS05410	COG2211	Major facilitator Superfamily
LEO73_RS05420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LEO73_RS05430	COG2813	Specifically methylates the guanine in position
LEO73_RS05435	COG0271	Belongs to the BolA IbaG family
LEO73_RS05440	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO73_RS05445	COG1805	sodium ion transport
LEO73_RS05450	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO73_RS05455	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO73_RS05460	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO73_RS05465	COG2871	sodium ion transport
LEO73_RS05470	COG1477	protein flavinylation
LEO73_RS05485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LEO73_RS05490	COG0840	transmembrane signaling receptor activity
LEO73_RS05495	COG0583	DNA-binding transcription factor activity
LEO73_RS05505	COG2363	Small membrane protein
LEO73_RS05510	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LEO73_RS05520	COG0473	3-isopropylmalate dehydrogenase activity
LEO73_RS05525	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEO73_RS05530	COG1611	Belongs to the LOG family
LEO73_RS05545	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LEO73_RS05545	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LEO73_RS05555	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
LEO73_RS05580	COG3098	single-species biofilm formation
LEO73_RS05585	COG0564	pseudouridine synthase activity
LEO73_RS05615	COG2171	N-acyltransferase activity
LEO73_RS05620	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LEO73_RS05625	COG0024	Methionine aminopeptidase
LEO73_RS05630	COG0052	Belongs to the universal ribosomal protein uS2 family
LEO73_RS05635	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LEO73_RS05640	COG0528	UMP kinase activity
LEO73_RS05645	COG0233	cytoplasmic translational termination
LEO73_RS05650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LEO73_RS05655	COG0575	Belongs to the CDS family
LEO73_RS05660	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LEO73_RS05665	COG0750	zinc metalloprotease
LEO73_RS05680	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEO73_RS05685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LEO73_RS05690	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEO73_RS05695	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEO73_RS05700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LEO73_RS05710	COG0825	malonyl-CoA metabolic process
LEO73_RS05715	COG3710	Transcriptional regulator
LEO73_RS05720	COG0531	amino acid
LEO73_RS05725	COG1982	Orn Lys Arg decarboxylase major
LEO73_RS05730	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LEO73_RS05745	COG0814	amino acid
LEO73_RS05750	COG0531	amino acid
LEO73_RS05760	COG0488	(ABC) transporter
LEO73_RS05770	COG3590	peptidase
LEO73_RS05780	COG3706	GGDEF domain
LEO73_RS05815	COG0366	Alpha amylase catalytic
LEO73_RS05830	COG0463	Glycosyl transferase, family 2
LEO73_RS05845	COG2989	Protein conserved in bacteria
LEO73_RS05850	COG3108	Peptidase M15
LEO73_RS05860	COG2860	membrane
LEO73_RS05870	COG1196	nuclear chromosome segregation
LEO73_RS05875	COG3115	cell septum assembly
LEO73_RS05880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LEO73_RS05890	COG1328	CTP reductase activity
LEO73_RS05895	COG0602	queuosine metabolic process
LEO73_RS05925	COG1566	PFAM secretion protein HlyD family protein
LEO73_RS05930	COG1846	Transcriptional regulator
LEO73_RS05945	COG0281	malic enzyme
LEO73_RS05950	COG3290	protein histidine kinase activity
LEO73_RS05955	COG4565	transcriptional regulatory protein
LEO73_RS05960	COG0697	spore germination
LEO73_RS05975	COG3284	Transcriptional regulator
LEO73_RS05980	COG1960	acyl-CoA dehydrogenase activity
LEO73_RS05985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LEO73_RS05990	COG0346	lactoylglutathione lyase activity
LEO73_RS05995	COG0745	RESPONSE REGULATOR receiver
LEO73_RS06000	COG5002	protein histidine kinase activity
LEO73_RS06035	COG0545	Peptidyl-prolyl cis-trans isomerase
LEO73_RS06040	COG1131	(ABC) transporter
LEO73_RS06055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO73_RS06060	COG4597	amino acid ABC transporter
LEO73_RS06065	COG0765	amino acid transport
LEO73_RS06070	COG1126	abc transporter atp-binding protein
LEO73_RS06080	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LEO73_RS06090	COG0678	peroxiredoxin activity
LEO73_RS06100	COG0019	diaminopimelate decarboxylase activity
LEO73_RS06105	COG1115	amino acid carrier protein
LEO73_RS06110	COG0095	Lipoate-protein ligase
LEO73_RS06115	COG2233	PERMEase
LEO73_RS06130	COG0534	Mate efflux family protein
LEO73_RS06135	COG2207	Transcriptional regulator
LEO73_RS06140	COG0281	malic enzyme
LEO73_RS06170	COG0733	neurotransmitter:sodium symporter activity
LEO73_RS06175	COG1752	Esterase of the alpha-beta hydrolase superfamily
LEO73_RS06185	COG1566	PFAM secretion protein HlyD family protein
LEO73_RS06190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO73_RS06200	COG1032	radical SAM domain protein
LEO73_RS06225	COG3152	Membrane
LEO73_RS06250	COG0673	inositol 2-dehydrogenase activity
LEO73_RS06255	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LEO73_RS06260	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LEO73_RS06265	COG1196	nuclear chromosome segregation
LEO73_RS06265	COG0741	lytic transglycosylase activity
LEO73_RS06265	COG0739	heme binding
LEO73_RS06270	COG0366	Alpha amylase catalytic
LEO73_RS06290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LEO73_RS06300	COG0788	formyltetrahydrofolate deformylase activity
LEO73_RS06305	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LEO73_RS06315	COG3118	belongs to the thioredoxin family
LEO73_RS06325	COG0791	NLP P60 protein
LEO73_RS06330	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
LEO73_RS06345	COG1388	LysM domain
LEO73_RS06345	COG1376	ErfK ybiS ycfS ynhG family protein
LEO73_RS06360	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LEO73_RS06425	COG2003	Belongs to the UPF0758 family
LEO73_RS06455	COG5377	YqaJ viral recombinase family
LEO73_RS06475	COG4983	Phage plasmid primase, P4 family domain protein
LEO73_RS06485	COG2916	Histone family protein nucleoid-structuring protein H-NS
LEO73_RS06505	COG3962	Belongs to the TPP enzyme family
LEO73_RS06510	COG0673	inositol 2-dehydrogenase activity
LEO73_RS06515	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LEO73_RS06525	COG2176	DNA-directed DNA polymerase activity
LEO73_RS06530	COG0673	inositol 2-dehydrogenase activity
LEO73_RS06545	COG3718	enzyme involved in inositol metabolism
LEO73_RS06550	COG0582	viral genome integration into host DNA
LEO73_RS06565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO73_RS06570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO73_RS06580	COG5002	protein histidine kinase activity
LEO73_RS06595	COG0583	DNA-binding transcription factor activity
LEO73_RS06600	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LEO73_RS06605	COG0243	molybdopterin cofactor binding
LEO73_RS06615	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LEO73_RS06625	COG1960	acyl-CoA dehydrogenase activity
LEO73_RS06640	COG0469	pyruvate kinase activity
LEO73_RS06645	COG1737	Transcriptional regulator
LEO73_RS06665	COG2274	protein secretion by the type I secretion system
LEO73_RS06675	COG2274	protein secretion by the type I secretion system
LEO73_RS06685	COG2994	toxin metabolic process
LEO73_RS06690	COG1073	alpha beta
LEO73_RS06690	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
LEO73_RS06690	COG3064	Membrane
LEO73_RS06695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LEO73_RS06715	COG1342	Belongs to the UPF0251 family
LEO73_RS06720	COG0640	Transcriptional regulator
LEO73_RS06735	COG0798	PFAM Bile acid sodium symporter
LEO73_RS06755	COG1677	Flagellar hook-basal body complex protein FliE
LEO73_RS06765	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LEO73_RS06820	COG1684	flagellar biosynthetic protein fliR
LEO73_RS06830	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LEO73_RS06855	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LEO73_RS06860	COG2198	Histidine kinase
LEO73_RS06860	COG0643	Histidine kinase
LEO73_RS06860	COG0784	Response regulator, receiver
LEO73_RS06865	COG2201	protein-glutamate methylesterase activity
LEO73_RS06870	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LEO73_RS06880	COG1192	Involved in chromosome partitioning
LEO73_RS06890	COG0835	chemotaxis
LEO73_RS06905	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LEO73_RS06910	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LEO73_RS06915	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LEO73_RS06920	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LEO73_RS06925	COG1138	Cytochrome C-type biogenesis protein
LEO73_RS06930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LEO73_RS06935	COG3088	subunit of a heme lyase
LEO73_RS06935	COG4235	cytochrome complex assembly
LEO73_RS06940	COG0457	Tetratricopeptide repeat
LEO73_RS06955	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LEO73_RS06960	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LEO73_RS06960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LEO73_RS06975	COG0259	pyridoxamine-phosphate oxidase activity
LEO73_RS06980	COG0625	glutathione transferase activity
LEO73_RS06990	COG3153	acetyltransferase
LEO73_RS07000	COG2850	peptidyl-arginine hydroxylation
LEO73_RS07005	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LEO73_RS07010	COG2915	High frequency lysogenization protein hflD homolog
LEO73_RS07015	COG0482	sulfurtransferase activity
LEO73_RS07025	COG1187	pseudouridine synthase activity
LEO73_RS07035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO73_RS07045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO73_RS07045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO73_RS07045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO73_RS07060	COG0456	acetyltransferase
LEO73_RS07075	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO73_RS07075	COG1902	pentaerythritol trinitrate reductase activity
LEO73_RS07080	COG1609	Transcriptional regulator
LEO73_RS07085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO73_RS07085	COG1263	PTS System
LEO73_RS07090	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LEO73_RS07100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO73_RS07120	COG2207	Transcriptional regulator
LEO73_RS07125	COG0538	isocitrate dehydrogenase activity
LEO73_RS07130	COG0659	secondary active sulfate transmembrane transporter activity
LEO73_RS07140	COG3048	D-serine ammonia-lyase activity
LEO73_RS07145	COG0583	DNA-binding transcription factor activity
LEO73_RS07150	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LEO73_RS07170	COG3311	Transcriptional regulator
LEO73_RS07195	COG2020	methyltransferase activity
LEO73_RS07200	COG2916	Histone family protein nucleoid-structuring protein H-NS
LEO73_RS07235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LEO73_RS07250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LEO73_RS07255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LEO73_RS07330	COG5642	Protein of unknown function (DUF2384)
LEO73_RS07335	COG0582	viral genome integration into host DNA
LEO73_RS07380	COG4974	Belongs to the 'phage' integrase family
LEO73_RS07390	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LEO73_RS07395	COG2867	negative regulation of translational initiation
LEO73_RS07400	COG2914	Belongs to the UPF0125 (RnfH) family
LEO73_RS07405	COG0702	epimerase
LEO73_RS07410	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LEO73_RS07415	COG1454	alcohol dehydrogenase
LEO73_RS07425	COG0564	pseudouridine synthase activity
LEO73_RS07455	COG1280	lysine exporter protein (LysE YggA)
LEO73_RS07475	COG3263	regulation of cellular component size
LEO73_RS07485	COG1876	peptidase activity
LEO73_RS07490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LEO73_RS07495	COG1393	Belongs to the ArsC family
LEO73_RS07500	COG0583	DNA-binding transcription factor activity
LEO73_RS07525	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LEO73_RS07530	COG0017	Asparaginyl-tRNA synthetase
LEO73_RS07550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LEO73_RS07555	COG0156	8-amino-7-oxononanoate synthase activity
LEO73_RS07560	COG1073	alpha beta
LEO73_RS07560	COG2226	methyltransferase
LEO73_RS07565	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LEO73_RS07570	COG0501	Belongs to the peptidase M48B family
LEO73_RS07580	COG3217	Mosc domain protein beta barrel domain protein
LEO73_RS07580	COG3217	Mosc domain protein beta barrel domain protein
LEO73_RS07580	COG0633	Ferredoxin
LEO73_RS07580	COG0633	Ferredoxin
LEO73_RS07590	COG0674	pyruvate-flavodoxin oxidoreductase activity
LEO73_RS07590	COG1013	pyruvate-flavodoxin oxidoreductase activity
LEO73_RS07590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LEO73_RS07590	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LEO73_RS07595	COG2366	antibiotic biosynthetic process
LEO73_RS07600	COG1917	Cupin 2, conserved barrel domain protein
LEO73_RS07600	COG2169	Transcriptional regulator
LEO73_RS07605	COG2841	Protein conserved in bacteria
LEO73_RS07615	COG0534	Mate efflux family protein
LEO73_RS07655	COG1309	transcriptional regulator
LEO73_RS07670	COG0791	NLP P60 protein
LEO73_RS07680	COG0583	DNA-binding transcription factor activity
LEO73_RS07685	COG0450	alkyl hydroperoxide reductase
LEO73_RS07705	COG0500	methyltransferase
LEO73_RS07710	COG4106	trans-aconitate 2-methyltransferase activity
LEO73_RS07715	COG1801	Protein of unknown function DUF72
LEO73_RS07720	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LEO73_RS07725	COG0217	transcriptional regulatory protein
LEO73_RS07730	COG2194	sulfuric ester hydrolase activity
LEO73_RS07740	COG1846	Transcriptional regulator
LEO73_RS07740	COG1940	carbohydrate kinase activity
LEO73_RS07745	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LEO73_RS07750	COG0363	glucosamine-6-phosphate deaminase activity
LEO73_RS07755	COG2190	(PTS) system
LEO73_RS07755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO73_RS07755	COG1263	PTS System
LEO73_RS07765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LEO73_RS07770	COG0735	belongs to the Fur family
LEO73_RS07780	COG0716	FMN binding
LEO73_RS07795	COG0596	Alpha beta hydrolase
LEO73_RS07800	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
LEO73_RS07805	COG0033	Phosphoglucomutase
LEO73_RS07815	COG1846	Transcriptional regulator
LEO73_RS07830	COG2951	lytic endotransglycosylase activity
LEO73_RS07835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LEO73_RS07840	COG4136	ATPase activity
LEO73_RS07850	COG4134	Bacterial extracellular solute-binding protein
LEO73_RS07860	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LEO73_RS07870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LEO73_RS07875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LEO73_RS07885	COG0729	surface antigen
LEO73_RS07890	COG2911	Protein conserved in bacteria
LEO73_RS07910	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LEO73_RS07920	COG0741	lytic transglycosylase activity
LEO73_RS07935	COG1607	acyl-coa hydrolase
LEO73_RS07945	COG3021	interspecies interaction between organisms
LEO73_RS07950	COG0741	lytic transglycosylase activity
LEO73_RS07950	COG1388	LysM domain
LEO73_RS07955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LEO73_RS07960	COG2226	methyltransferase
LEO73_RS07965	COG0328	RNA-DNA hybrid ribonuclease activity
LEO73_RS07970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LEO73_RS07980	COG3437	response regulator, receiver
LEO73_RS07980	COG0784	Response regulator, receiver
LEO73_RS07985	COG1960	acyl-CoA dehydrogenase activity
LEO73_RS07990	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LEO73_RS07995	COG0121	glutamine amidotransferase
LEO73_RS08015	COG2205	protein histidine kinase activity
LEO73_RS08015	COG0784	Response regulator, receiver
LEO73_RS08025	COG2197	response regulator
LEO73_RS08030	COG3850	Histidine kinase
LEO73_RS08035	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LEO73_RS08040	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO73_RS08040	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO73_RS08050	COG0243	molybdopterin cofactor binding
LEO73_RS08055	COG0437	4 iron, 4 sulfur cluster binding
LEO73_RS08060	COG0348	domain, Protein
LEO73_RS08070	COG3005	denitrification pathway
LEO73_RS08075	COG0521	Mo-molybdopterin cofactor biosynthetic process
LEO73_RS08080	COG0315	cyclic pyranopterin monophosphate synthase activity
LEO73_RS08085	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LEO73_RS08090	COG0314	molybdopterin synthase activity
LEO73_RS08105	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LEO73_RS08110	COG2267	carboxylic ester hydrolase activity
LEO73_RS08115	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LEO73_RS08125	COG0302	gtp cyclohydrolase
LEO73_RS08130	COG0840	transmembrane signaling receptor activity
LEO73_RS08135	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LEO73_RS08145	COG0583	DNA-binding transcription factor activity
LEO73_RS08175	COG2195	Cleaves the N-terminal amino acid of tripeptides
LEO73_RS08185	COG1166	arginine decarboxylase activity
LEO73_RS08195	COG2015	COG2015, Alkyl sulfatase and related hydrolases
LEO73_RS08200	COG0583	DNA-binding transcription factor activity
LEO73_RS08220	COG0814	amino acid
LEO73_RS08230	COG3681	Belongs to the UPF0597 family
LEO73_RS08235	COG2964	Protein conserved in bacteria
LEO73_RS08245	COG1061	Type III restriction enzyme res subunit
LEO73_RS08255	COG0346	lactoylglutathione lyase activity
LEO73_RS08265	COG1187	pseudouridine synthase activity
LEO73_RS08275	COG2807	transmembrane transport
LEO73_RS08285	COG0583	DNA-binding transcription factor activity
LEO73_RS08290	COG2271	Major facilitator Superfamily
LEO73_RS08320	COG2979	Protein of unknown function (DUF533)
LEO73_RS08330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LEO73_RS08340	COG1294	oxidase, subunit
LEO73_RS08360	COG3220	belongs to the UPF0276 family
LEO73_RS08375	COG2814	Major facilitator Superfamily
LEO73_RS08380	COG0656	L-ascorbic acid biosynthetic process
LEO73_RS08415	COG0583	DNA-binding transcription factor activity
LEO73_RS08425	COG0840	transmembrane signaling receptor activity
LEO73_RS08430	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LEO73_RS08435	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LEO73_RS08440	COG2271	Major facilitator Superfamily
LEO73_RS08445	COG1349	DNA-binding transcription factor activity
LEO73_RS08460	COG0584	glycerophosphoryl diester phosphodiesterase
LEO73_RS08465	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEO73_RS08470	COG1605	Chorismate mutase
LEO73_RS08470	COG0287	Prephenate dehydrogenase
LEO73_RS08475	COG0583	DNA-binding transcription factor activity
LEO73_RS08480	COG3085	chromosome segregation
LEO73_RS08485	COG4574	serine-type endopeptidase inhibitor activity
LEO73_RS08505	COG1770	oligopeptidase
LEO73_RS08510	COG4771	TonB-dependent receptor
LEO73_RS08515	COG3083	sulfuric ester hydrolase activity
LEO73_RS08520	COG3082	Protein of unknown function (DUF1414)
LEO73_RS08525	COG3081	Nucleoid-associated protein
LEO73_RS08535	COG1175	transmembrane transport
LEO73_RS08540	COG3833	ABC-type maltose transport systems, permease component
LEO73_RS08545	COG3842	ATPase activity
LEO73_RS08555	COG0596	Alpha beta hydrolase
LEO73_RS08570	COG0425	Belongs to the sulfur carrier protein TusA family
LEO73_RS08575	COG4783	chaperone-mediated protein folding
LEO73_RS08585	COG1393	Belongs to the ArsC family
LEO73_RS08610	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LEO73_RS08615	COG2431	L-lysine efflux transmembrane transporter activity
LEO73_RS08625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO73_RS08645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LEO73_RS08655	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO73_RS08660	COG2373	Large extracellular alpha-helical protein
LEO73_RS08665	COG4953	penicillin-binding protein 1C
LEO73_RS08675	COG0301	tRNA thio-modification
LEO73_RS08675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LEO73_RS08695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LEO73_RS08745	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LEO73_RS08765	COG0483	inositol monophosphate 1-phosphatase activity
LEO73_RS08775	COG0625	glutathione transferase activity
LEO73_RS08780	COG2814	Major facilitator Superfamily
LEO73_RS08800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LEO73_RS08805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LEO73_RS08810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LEO73_RS08815	COG0509	glycine decarboxylation via glycine cleavage system
LEO73_RS08820	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LEO73_RS08820	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LEO73_RS08825	COG0641	radical SAM
LEO73_RS08830	COG3119	arylsulfatase activity
LEO73_RS08845	COG3852	Histidine kinase
LEO73_RS08850	COG0477	Major facilitator Superfamily
LEO73_RS08855	COG3634	alkyl hydroperoxide reductase activity
LEO73_RS08865	COG0517	IMP dehydrogenase activity
LEO73_RS08870	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LEO73_RS08875	COG0343	queuine tRNA-ribosyltransferase activity
LEO73_RS08880	COG1862	Preprotein translocase
LEO73_RS08885	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEO73_RS08890	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEO73_RS08905	COG0826	peptidase U32
LEO73_RS08910	COG0826	peptidase U32
LEO73_RS08915	COG3154	lipid carrier protein
LEO73_RS08935	COG1104	cysteine desulfurase activity
LEO73_RS08940	COG0822	iron-sulfur transferase activity
LEO73_RS08950	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LEO73_RS08955	COG0443	Heat shock 70 kDa protein
LEO73_RS08960	COG0633	Ferredoxin
LEO73_RS08970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LEO73_RS08975	COG0105	UTP biosynthetic process
LEO73_RS08980	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LEO73_RS08995	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LEO73_RS09000	COG0124	histidyl-tRNA synthetase
LEO73_RS09005	COG2976	Protein conserved in bacteria
LEO73_RS09010	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LEO73_RS09015	COG1160	GTP binding
LEO73_RS09020	COG1645	bacterial-type flagellum-dependent swarming motility
LEO73_RS09025	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LEO73_RS09030	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LEO73_RS09030	COG0047	phosphoribosylformylglycinamidine synthase activity
LEO73_RS09035	COG2199	diguanylate cyclase activity
LEO73_RS09035	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEO73_RS09050	COG1007	ATP synthesis coupled electron transport
LEO73_RS09055	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO73_RS09065	COG0713	ATP synthesis coupled electron transport
LEO73_RS09070	COG0839	Belongs to the complex I subunit 6 family
LEO73_RS09075	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO73_RS09080	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LEO73_RS09085	COG1034	ATP synthesis coupled electron transport
LEO73_RS09100	COG0649	NAD binding
LEO73_RS09100	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO73_RS09105	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO73_RS09110	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO73_RS09115	COG1360	Flagellar Motor Protein
LEO73_RS09120	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LEO73_RS09145	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LEO73_RS09165	COG0724	RNA recognition motif
LEO73_RS09170	COG4989	oxidoreductase activity
LEO73_RS09195	COG3437	response regulator, receiver
LEO73_RS09200	COG0583	DNA-binding transcription factor activity
LEO73_RS09210	COG5001	Diguanylate cyclase
LEO73_RS09210	COG3300	MHYT domain
LEO73_RS09215	COG0778	Nitroreductase
LEO73_RS09235	COG0583	DNA-binding transcription factor activity
LEO73_RS09245	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LEO73_RS09250	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LEO73_RS09255	COG0539	negative regulation of cytoplasmic translation
LEO73_RS09260	COG0776	regulation of translation
LEO73_RS09270	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LEO73_RS09290	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LEO73_RS09295	COG0602	queuosine metabolic process
LEO73_RS09300	COG3530	Putative quorum-sensing-regulated virulence factor
LEO73_RS09305	COG2096	Adenosyltransferase
LEO73_RS09310	COG2916	Histone family protein nucleoid-structuring protein H-NS
LEO73_RS09315	COG1757	Na H antiporter
LEO73_RS09320	COG1435	thymidine kinase activity
LEO73_RS09350	COG3501	Rhs element vgr protein
LEO73_RS09425	COG3829	transcription factor binding
LEO73_RS09490	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LEO73_RS09495	COG1278	Cold shock
LEO73_RS09500	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LEO73_RS09505	COG0542	response to heat
LEO73_RS09510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LEO73_RS09515	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LEO73_RS09520	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LEO73_RS09525	COG3134	Outer membrane lipoprotein
LEO73_RS09530	COG3706	GGDEF domain
LEO73_RS09535	COG0492	ferredoxin-NADP+ reductase activity
LEO73_RS09545	COG1674	ftsk spoiiie
LEO73_RS09545	COG0531	amino acid
LEO73_RS09550	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LEO73_RS09555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LEO73_RS09560	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LEO73_RS09565	COG1286	toxin biosynthetic process
LEO73_RS09570	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LEO73_RS09580	COG4172	Belongs to the ABC transporter superfamily
LEO73_RS09590	COG4171	peptide transport system, permease
LEO73_RS09595	COG4168	peptide transport system, permease
LEO73_RS09605	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LEO73_RS09610	COG1842	Phage shock protein A
LEO73_RS09625	COG3106	COG3106 Predicted ATPase
LEO73_RS09630	COG3768	UPF0283 membrane protein
LEO73_RS09640	COG2154	pterin-4-alpha-carbinolamine dehydratase
LEO73_RS09660	COG2885	chlorophyll binding
LEO73_RS09665	COG0861	Integral membrane protein TerC family
LEO73_RS09680	COG1022	Amp-dependent synthetase and ligase
LEO73_RS09685	COG0295	cytidine deaminase activity
LEO73_RS09690	COG1346	cytolysis
LEO73_RS09695	COG1380	Effector of murein hydrolase LrgA
LEO73_RS09700	COG3345	alpha-galactosidase
LEO73_RS09710	COG2925	Exonuclease
LEO73_RS09730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LEO73_RS09760	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LEO73_RS09795	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LEO73_RS09800	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LEO73_RS09815	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LEO73_RS09845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LEO73_RS09850	COG0254	rRNA binding
LEO73_RS09865	COG1451	nucleotide metabolic process
LEO73_RS09880	COG3069	C4-dicarboxylate transmembrane transporter activity
LEO73_RS09890	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LEO73_RS09890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO73_RS09895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LEO73_RS09920	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LEO73_RS09935	COG0567	Dehydrogenase, E1 component
LEO73_RS09940	COG0508	dehydrogenase complex catalyzes the overall conversion of
LEO73_RS09945	COG0045	succinate-CoA ligase (ADP-forming) activity
LEO73_RS09950	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LEO73_RS09970	COG2983	Belongs to the UPF0260 family
LEO73_RS09975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO73_RS09985	COG3842	ATPase activity
LEO73_RS09990	COG1840	ABC-type Fe3 transport system, periplasmic component
LEO73_RS10000	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LEO73_RS10005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LEO73_RS10010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO73_RS10015	COG1882	Formate acetyltransferase
LEO73_RS10020	COG2116	formate transmembrane transporter activity
LEO73_RS10025	COG1944	ATP diphosphatase activity
LEO73_RS10035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LEO73_RS10040	COG0612	Peptidase, M16
LEO73_RS10045	COG0626	cystathionine gamma-synthase activity
LEO73_RS10055	COG2910	NAD(P)H-binding
LEO73_RS10060	COG0583	DNA-binding transcription factor activity
LEO73_RS10070	COG4977	sequence-specific DNA binding
LEO73_RS10075	COG4774	siderophore transport
LEO73_RS10085	COG0583	DNA-binding transcription factor activity
LEO73_RS10090	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LEO73_RS10105	COG0516	GMP reductase activity
LEO73_RS10105	COG0517	IMP dehydrogenase activity
LEO73_RS10110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO73_RS10115	COG3046	protein related to deoxyribodipyrimidine photolyase
LEO73_RS10125	COG3033	Beta-eliminating lyase
LEO73_RS10140	COG3088	subunit of a heme lyase
LEO73_RS10140	COG4235	cytochrome complex assembly
LEO73_RS10150	COG1138	Cytochrome C-type biogenesis protein
LEO73_RS10155	COG3301	Polysulphide reductase, NrfD
LEO73_RS10160	COG0437	4 iron, 4 sulfur cluster binding
LEO73_RS10165	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
LEO73_RS10185	COG0247	lactate metabolic process
LEO73_RS10190	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
LEO73_RS10195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LEO73_RS10200	COG3012	SEC-C Motif Domain Protein
LEO73_RS10205	COG0840	transmembrane signaling receptor activity
LEO73_RS10210	COG1846	Transcriptional regulator
LEO73_RS10210	COG1940	carbohydrate kinase activity
LEO73_RS10215	COG3290	protein histidine kinase activity
LEO73_RS10220	COG4565	transcriptional regulatory protein
LEO73_RS10235	COG3181	Tripartite tricarboxylate transporter family receptor
LEO73_RS10240	COG1196	nuclear chromosome segregation
LEO73_RS10240	COG0741	lytic transglycosylase activity
LEO73_RS10240	COG0739	heme binding
LEO73_RS10245	COG2985	domain, Protein
LEO73_RS10245	COG0569	domain protein
LEO73_RS10255	COG0556	nucleotide-excision repair
LEO73_RS10265	COG0586	Pfam SNARE associated Golgi protein
LEO73_RS10270	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LEO73_RS10275	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LEO73_RS10280	COG2186	Transcriptional regulator
LEO73_RS10285	COG2719	SpoVR family
LEO73_RS10290	COG2718	Belongs to the UPF0229 family
LEO73_RS10295	COG2766	serine protein kinase
LEO73_RS10300	COG0514	ATP-dependent DNA helicase (RecQ)
LEO73_RS10305	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LEO73_RS10405	COG0058	SHG alpha-glucan phosphorylase activity
LEO73_RS10410	COG0471	metal ion transport
LEO73_RS10415	COG3118	belongs to the thioredoxin family
LEO73_RS10425	COG1132	(ABC) transporter
LEO73_RS10430	COG1132	(ABC) transporter
LEO73_RS10445	COG2501	S4 domain
LEO73_RS10455	COG3243	poly(R)-hydroxyalkanoic acid synthase
LEO73_RS10475	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LEO73_RS10480	COG2329	Antibiotic biosynthesis monooxygenase
LEO73_RS10520	COG0513	Belongs to the DEAD box helicase family
LEO73_RS10525	COG0386	Belongs to the glutathione peroxidase family
LEO73_RS10535	COG1181	Belongs to the D-alanine--D-alanine ligase family
LEO73_RS10545	COG3148	PFAM DTW domain containing protein
LEO73_RS10550	COG0730	response to heat
LEO73_RS10555	COG0583	DNA-binding transcription factor activity
LEO73_RS10570	COG3593	DNA synthesis involved in DNA repair
LEO73_RS10625	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LEO73_RS10630	COG1011	Hydrolase
LEO73_RS10635	COG1473	amidohydrolase
LEO73_RS10640	COG0205	6-phosphofructokinase activity
LEO73_RS10650	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LEO73_RS10655	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEO73_RS10665	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
LEO73_RS10670	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LEO73_RS10675	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LEO73_RS10700	COG0242	peptide deformylase activity
LEO73_RS10725	COG0384	phenazine biosynthesis protein PhzF
LEO73_RS10740	COG2824	Alkylphosphonate utilization operon protein PhnA
LEO73_RS10765	COG0588	phosphoglycerate mutase activity
LEO73_RS10770	COG3706	GGDEF domain
LEO73_RS10780	COG2840	Smr protein MutS2
LEO73_RS10785	COG2890	protein-(glutamine-N5) methyltransferase activity
LEO73_RS10790	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LEO73_RS10800	COG0513	Belongs to the DEAD box helicase family
LEO73_RS10815	COG0814	amino acid
LEO73_RS10820	COG1609	Transcriptional regulator
LEO73_RS10825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO73_RS10825	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO73_RS10830	COG1105	Belongs to the carbohydrate kinase PfkB family
LEO73_RS10835	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO73_RS10835	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO73_RS10835	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LEO73_RS10840	COG3313	Fe-S protein
LEO73_RS10845	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LEO73_RS10850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LEO73_RS10860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LEO73_RS10870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEO73_RS10895	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LEO73_RS10900	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LEO73_RS10905	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LEO73_RS10910	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LEO73_RS10915	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LEO73_RS10920	COG0072	phenylalanine-tRNA ligase activity
LEO73_RS10920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO73_RS10925	COG0776	regulation of translation
LEO73_RS10930	COG0784	Response regulator, receiver
LEO73_RS10930	COG2205	protein histidine kinase activity
LEO73_RS10955	COG2199	diguanylate cyclase activity
LEO73_RS10960	COG1609	Transcriptional regulator
LEO73_RS10965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO73_RS10970	COG1879	ABC-type sugar transport system periplasmic component
LEO73_RS10975	COG1172	Belongs to the binding-protein-dependent transport system permease family
LEO73_RS10980	COG1129	ABC transporter
LEO73_RS10985	COG1869	D-ribose catabolic process
LEO73_RS11005	COG0037	tRNA processing
LEO73_RS11010	COG0589	response to stress
LEO73_RS11015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEO73_RS11040	COG2010	Cytochrome c
LEO73_RS11055	COG3278	Belongs to the heme-copper respiratory oxidase family
LEO73_RS11065	COG1956	GAF domain-containing protein
LEO73_RS11070	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
LEO73_RS11080	COG0308	aminopeptidase N
LEO73_RS11090	COG2902	Dehydrogenase
LEO73_RS11095	COG0167	dihydroorotate dehydrogenase activity
LEO73_RS11105	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LEO73_RS11105	COG0116	Belongs to the methyltransferase superfamily
LEO73_RS11115	COG0488	(ABC) transporter
LEO73_RS11130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LEO73_RS11135	COG1067	ATP-dependent peptidase activity
LEO73_RS11145	COG3141	response to X-ray
LEO73_RS11155	COG4221	oxidoreductase activity
LEO73_RS11205	COG0372	Belongs to the citrate synthase family
LEO73_RS11210	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LEO73_RS11220	COG2995	paraquat-inducible protein a
LEO73_RS11225	COG3008	intermembrane lipid transfer
LEO73_RS11230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LEO73_RS11230	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LEO73_RS11245	COG0084	hydrolase, TatD family'
LEO73_RS11250	COG0470	DNA polymerase III
LEO73_RS11255	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LEO73_RS11260	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LEO73_RS11265	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LEO73_RS11275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LEO73_RS11280	COG1028	Short-chain dehydrogenase reductase Sdr
LEO73_RS11290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LEO73_RS11295	COG0416	fatty acid biosynthetic process
LEO73_RS11300	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LEO73_RS11305	COG1399	metal-binding, possibly nucleic acid-binding protein
LEO73_RS11315	COG0424	maF-like protein
LEO73_RS11320	COG0546	phosphoglycolate phosphatase activity
LEO73_RS11325	COG0564	pseudouridine synthase activity
LEO73_RS11330	COG1530	ribonuclease E activity
LEO73_RS11335	COG0306	phosphate transporter
LEO73_RS11340	COG0717	Belongs to the dCTP deaminase family
LEO73_RS11345	COG0572	uridine kinase
LEO73_RS11350	COG0489	protein tyrosine kinase activity
LEO73_RS11355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO73_RS11355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO73_RS11360	COG0625	glutathione transferase activity
LEO73_RS11365	COG1254	Belongs to the acylphosphatase family
LEO73_RS11370	COG0840	transmembrane signaling receptor activity
LEO73_RS11375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LEO73_RS11385	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LEO73_RS11400	COG0709	Synthesizes selenophosphate from selenide and ATP
LEO73_RS11405	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
LEO73_RS11410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LEO73_RS11415	COG3437	response regulator, receiver
LEO73_RS11425	COG2205	protein histidine kinase activity
LEO73_RS11425	COG3437	response regulator, receiver
LEO73_RS11425	COG3850	Histidine kinase
LEO73_RS11425	COG4999	Histidine kinase
LEO73_RS11430	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LEO73_RS11440	COG1643	Atp-dependent helicase
LEO73_RS11445	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LEO73_RS11445	COG0517	IMP dehydrogenase activity
LEO73_RS11445	COG0617	tRNA 3'-terminal CCA addition
LEO73_RS11455	COG3314	Sporulation integral membrane protein YlbJ
LEO73_RS11465	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LEO73_RS11470	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LEO73_RS11480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LEO73_RS11485	COG2832	Protein of unknown function (DUF454)
LEO73_RS11490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LEO73_RS11505	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LEO73_RS11510	COG0318	PFAM AMP-dependent synthetase and ligase
LEO73_RS11515	COG2267	carboxylic ester hydrolase activity
LEO73_RS11525	COG1214	PFAM Peptidase M22, glycoprotease
LEO73_RS11535	COG1199	ATP-dependent helicase activity
LEO73_RS11545	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LEO73_RS11550	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LEO73_RS11555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LEO73_RS11560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LEO73_RS11560	COG0131	Imidazoleglycerol-phosphate dehydratase
LEO73_RS11565	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LEO73_RS11570	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LEO73_RS11575	COG3437	response regulator, receiver
LEO73_RS11580	COG2199	diguanylate cyclase activity
LEO73_RS11585	COG0784	Response regulator, receiver
LEO73_RS11585	COG5002	protein histidine kinase activity
LEO73_RS11585	COG2205	protein histidine kinase activity
LEO73_RS11590	COG0107	imidazoleglycerol-phosphate synthase activity
LEO73_RS11595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LEO73_RS11595	COG0140	phosphoribosyl-ATP diphosphatase activity
LEO73_RS11605	COG2378	regulation of single-species biofilm formation
LEO73_RS11610	COG0318	PFAM AMP-dependent synthetase and ligase
LEO73_RS11615	COG1288	antiporter activity
LEO73_RS11625	COG3134	Outer membrane lipoprotein
LEO73_RS11635	COG2080	2 iron, 2 sulfur cluster binding
LEO73_RS11640	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LEO73_RS11645	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LEO73_RS11650	COG2252	PERMEase
LEO73_RS11655	COG0402	S-adenosylhomocysteine deaminase activity
LEO73_RS11660	COG2233	PERMEase
LEO73_RS11665	COG2080	2 iron, 2 sulfur cluster binding
LEO73_RS11665	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LEO73_RS11670	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LEO73_RS11675	COG0402	S-adenosylhomocysteine deaminase activity
LEO73_RS11680	COG0493	'glutamate synthase
LEO73_RS11680	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO73_RS11685	COG2068	MobA-Related Protein
LEO73_RS11690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LEO73_RS11695	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LEO73_RS11695	COG3608	succinylglutamate desuccinylase aspartoacylase
LEO73_RS11700	COG0697	spore germination
LEO73_RS11705	COG0549	Belongs to the carbamate kinase family
LEO73_RS11715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LEO73_RS11720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LEO73_RS11725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LEO73_RS11730	COG3829	transcription factor binding
LEO73_RS11770	COG1024	Enoyl-CoA hydratase
LEO73_RS11770	COG1250	3-hydroxyacyl-CoA dehydrogenase
LEO73_RS11775	COG0183	Belongs to the thiolase family
LEO73_RS11780	COG0714	Associated with various cellular activities
LEO73_RS11810	COG1595	DNA-templated transcription, initiation
LEO73_RS11825	COG2067	long-chain fatty acid transport protein
LEO73_RS11830	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LEO73_RS11850	COG3123	guanosine phosphorylase activity
LEO73_RS11855	COG1760	l-serine dehydratase
LEO73_RS11860	COG1760	l-serine dehydratase
LEO73_RS11865	COG2951	lytic endotransglycosylase activity
LEO73_RS11870	COG3100	YcgL domain-containing protein
LEO73_RS11875	COG0850	regulation of cytokinetic process
LEO73_RS11880	COG2894	cell division
LEO73_RS11885	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LEO73_RS11890	COG3099	Belongs to the UPF0263 family
LEO73_RS11895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LEO73_RS11935	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LEO73_RS11940	COG0697	spore germination
LEO73_RS11945	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LEO73_RS11950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO73_RS11960	COG0307	riboflavin synthase, alpha
LEO73_RS11970	COG0534	Mate efflux family protein
LEO73_RS12000	COG0417	DNA replication proofreading
LEO73_RS12010	COG3300	MHYT domain
LEO73_RS12010	COG5001	Diguanylate cyclase
LEO73_RS12025	COG1560	Kdo2-lipid A biosynthetic process
LEO73_RS12030	COG1560	Kdo2-lipid A biosynthetic process
LEO73_RS12040	COG0583	DNA-binding transcription factor activity
LEO73_RS12045	COG0673	inositol 2-dehydrogenase activity
LEO73_RS12050	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LEO73_RS12055	COG0583	DNA-binding transcription factor activity
LEO73_RS12065	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEO73_RS12070	COG2723	6-phospho-beta-galactosidase activity
LEO73_RS12075	COG0583	DNA-binding transcription factor activity
LEO73_RS12080	COG0438	transferase activity, transferring glycosyl groups
LEO73_RS12150	COG0438	transferase activity, transferring glycosyl groups
LEO73_RS12155	COG1215	transferase activity, transferring glycosyl groups
LEO73_RS12160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LEO73_RS12215	COG0667	Aldo Keto reductase
LEO73_RS12225	COG0702	epimerase
LEO73_RS12230	COG0823	Involved in the tonB-independent uptake of proteins
LEO73_RS12230	COG1506	peptidase
LEO73_RS12235	COG1073	alpha beta
LEO73_RS12250	COG0730	response to heat
LEO73_RS12260	COG1028	Short-chain dehydrogenase reductase Sdr
LEO73_RS12270	COG1024	Enoyl-CoA hydratase
LEO73_RS12275	COG1024	Enoyl-CoA hydratase
LEO73_RS12280	COG1960	acyl-CoA dehydrogenase activity
LEO73_RS12290	COG1960	acyl-CoA dehydrogenase activity
LEO73_RS12295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LEO73_RS12330	COG1584	GPR1 FUN34 yaaH family protein
LEO73_RS12345	COG1115	amino acid carrier protein
LEO73_RS12385	COG1024	Enoyl-CoA hydratase
LEO73_RS12400	COG3162	membrane
LEO73_RS12405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LEO73_RS12410	COG0488	(ABC) transporter
LEO73_RS12415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LEO73_RS12420	COG0776	regulation of translation
LEO73_RS12425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LEO73_RS12430	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LEO73_RS12435	COG0740	serine-type endopeptidase activity
LEO73_RS12440	COG0544	peptidyl-prolyl cis-trans isomerase activity
LEO73_RS12450	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LEO73_RS12455	COG4591	ABC-type transport system involved in lipoprotein release permease component
LEO73_RS12460	COG1136	(ABC) transporter
LEO73_RS12465	COG4591	ABC-type transport system involved in lipoprotein release permease component
LEO73_RS12475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LEO73_RS12480	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LEO73_RS12485	COG4166	transmembrane transport
LEO73_RS12490	COG0697	spore germination
LEO73_RS12500	COG2062	phosphohistidine phosphatase, SixA
LEO73_RS12540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LEO73_RS12540	COG0519	Catalyzes the synthesis of GMP from XMP
LEO73_RS12545	COG0516	GMP reductase activity
LEO73_RS12545	COG0517	IMP dehydrogenase activity
LEO73_RS12550	COG3158	transport of potassium into the cell
LEO73_RS12570	COG0697	spore germination
LEO73_RS12575	COG1570	exodeoxyribonuclease VII activity
LEO73_RS12590	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEO73_RS12595	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LEO73_RS12600	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LEO73_RS12640	COG4771	TonB-dependent receptor
LEO73_RS12645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEO73_RS12650	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEO73_RS12655	COG1120	ATPase activity
LEO73_RS12665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LEO73_RS12670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LEO73_RS12680	COG1028	Short-chain dehydrogenase reductase Sdr
LEO73_RS12685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LEO73_RS12690	COG1535	isochorismatase
LEO73_RS12690	COG3433	isochorismatase activity
LEO73_RS12695	COG1021	2,3-dihydroxybenzoate-AMP ligase
LEO73_RS12720	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LEO73_RS12725	COG3300	MHYT domain
LEO73_RS12725	COG5001	Diguanylate cyclase
LEO73_RS12740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO73_RS12745	COG3788	relative of glutathione S-transferase, MAPEG superfamily
LEO73_RS12750	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LEO73_RS12755	COG0563	adenylate kinase activity
LEO73_RS12760	COG0326	Molecular chaperone. Has ATPase activity
LEO73_RS12765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LEO73_RS12790	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO73_RS12800	COG0454	-acetyltransferase
LEO73_RS12805	COG3158	transport of potassium into the cell
LEO73_RS12810	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO73_RS12815	COG0651	ATP synthesis coupled electron transport
LEO73_RS12820	COG0650	Formate hydrogenlyase subunit 4
LEO73_RS12825	COG3261	NADH dehydrogenase
LEO73_RS12825	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
LEO73_RS12830	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO73_RS12835	COG3260	NADH ubiquinone oxidoreductase 20
LEO73_RS12845	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LEO73_RS12855	COG1921	L-seryl-tRNASec selenium transferase activity
LEO73_RS12865	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LEO73_RS12870	COG0298	carbon dioxide binding
LEO73_RS12880	COG0309	Hydrogenase expression formation protein (HypE)
LEO73_RS12885	COG0375	protein maturation
LEO73_RS12895	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LEO73_RS12900	COG3842	ATPase activity
LEO73_RS12905	COG0444	Belongs to the ABC transporter superfamily
LEO73_RS12910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEO73_RS12915	COG0601	transmembrane transport
LEO73_RS12925	COG1773	rubredoxin
LEO73_RS12930	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LEO73_RS12935	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LEO73_RS12940	COG5557	Pfam Polysulphide reductase, NrfD
LEO73_RS12945	COG0437	4 iron, 4 sulfur cluster binding
LEO73_RS12950	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
LEO73_RS12955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LEO73_RS12960	COG0582	viral genome integration into host DNA
LEO73_RS12985	COG3675	Pfam Lipase (class 3)
LEO73_RS13090	COG2003	Belongs to the UPF0758 family
LEO73_RS13150	COG0210	DNA helicase
LEO73_RS13155	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LEO73_RS13205	COG0659	secondary active sulfate transmembrane transporter activity
LEO73_RS13245	COG0672	)-iron permease
LEO73_RS13265	COG2814	Major facilitator Superfamily
LEO73_RS13285	COG1136	(ABC) transporter
LEO73_RS13290	COG0577	efflux transmembrane transporter activity
LEO73_RS13320	COG1139	Iron-sulfur cluster binding protein
LEO73_RS13325	COG0247	lactate metabolic process
LEO73_RS13330	COG1620	l-lactate permease
LEO73_RS13335	COG0583	DNA-binding transcription factor activity
LEO73_RS13340	COG0596	Alpha beta hydrolase
LEO73_RS13360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LEO73_RS13365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LEO73_RS13365	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LEO73_RS13370	COG0527	aspartate kinase activity
LEO73_RS13380	COG1368	sulfuric ester hydrolase activity
LEO73_RS13385	COG1619	proteins homologs of microcin C7 resistance protein MccF
LEO73_RS13395	COG0393	Putative heavy-metal-binding
LEO73_RS13415	COG1252	NADH dehydrogenase
LEO73_RS13420	COG3150	esterase
LEO73_RS13425	COG2233	PERMEase
LEO73_RS13440	COG2354	Protein conserved in bacteria
LEO73_RS13455	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEO73_RS13460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEO73_RS13495	COG0537	adenosine 5'-monophosphoramidase activity
LEO73_RS13510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LEO73_RS13525	COG1301	dicarboxylic acid transport
LEO73_RS13535	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LEO73_RS13540	COG0861	Integral membrane protein TerC family
LEO73_RS13550	COG0444	Belongs to the ABC transporter superfamily
LEO73_RS13555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEO73_RS13560	COG0601	transmembrane transport
LEO73_RS13570	COG2095	MarC family integral membrane protein
LEO73_RS13580	COG1454	alcohol dehydrogenase
LEO73_RS13580	COG1012	belongs to the aldehyde dehydrogenase family
LEO73_RS13585	COG2199	diguanylate cyclase activity
LEO73_RS13585	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEO73_RS13590	COG3275	phosphorelay sensor kinase activity
LEO73_RS13595	COG3279	Response regulator of the LytR AlgR family
LEO73_RS13600	COG1966	Carbon starvation protein
LEO73_RS13610	COG1566	PFAM secretion protein HlyD family protein
LEO73_RS13615	COG1061	Type III restriction enzyme res subunit
LEO73_RS13620	COG2027	D-alanyl-D-alanine carboxypeptidase
LEO73_RS13625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LEO73_RS13635	COG0436	Aminotransferase
LEO73_RS13640	COG3264	Mechanosensitive ion channel
LEO73_RS13640	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LEO73_RS13645	COG1288	antiporter activity
LEO73_RS13650	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LEO73_RS13665	COG0697	spore germination
LEO73_RS13670	COG4657	Part of a membrane complex involved in electron transport
LEO73_RS13675	COG2878	Part of a membrane complex involved in electron transport
LEO73_RS13685	COG4658	electron transport chain
LEO73_RS13690	COG4659	FMN binding
LEO73_RS13695	COG4660	Part of a membrane complex involved in electron transport
LEO73_RS13700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LEO73_RS13705	COG0346	lactoylglutathione lyase activity
LEO73_RS13720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LEO73_RS13725	COG2056	Na+-H+ antiporter family
LEO73_RS13735	COG2050	protein possibly involved in aromatic compounds catabolism
LEO73_RS13745	COG0277	FAD linked oxidase domain protein
LEO73_RS13745	COG0247	lactate metabolic process
LEO73_RS13755	COG1253	flavin adenine dinucleotide binding
LEO73_RS13760	COG1902	pentaerythritol trinitrate reductase activity
LEO73_RS13765	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LEO73_RS13770	COG0647	UMP catabolic process
LEO73_RS13775	COG4651	solute:proton antiporter activity
LEO73_RS13775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LEO73_RS13785	COG0367	asparagine synthase
LEO73_RS13795	COG0625	glutathione transferase activity
LEO73_RS13805	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LEO73_RS13820	COG0564	pseudouridine synthase activity
LEO73_RS13825	COG5001	Diguanylate cyclase
LEO73_RS13830	COG0840	transmembrane signaling receptor activity
LEO73_RS13840	COG0392	lysyltransferase activity
LEO73_RS13840	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LEO73_RS13845	COG2194	sulfuric ester hydrolase activity
LEO73_RS13870	COG0670	Belongs to the BI1 family
LEO73_RS13875	COG1289	transmembrane transporter activity
LEO73_RS13880	COG2920	part of a sulfur-relay system
LEO73_RS13885	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LEO73_RS13890	COG0285	dihydrofolate synthase activity
LEO73_RS13895	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LEO73_RS13900	COG0101	tRNA pseudouridine synthase activity
LEO73_RS13910	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LEO73_RS13915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LEO73_RS13920	COG0671	phosphoesterase, PA-phosphatase related
LEO73_RS13925	COG1464	Belongs to the NlpA lipoprotein family
LEO73_RS13965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LEO73_RS13965	COG0574	Belongs to the PEP-utilizing enzyme family
LEO73_RS13970	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LEO73_RS14025	COG1242	4 iron, 4 sulfur cluster binding
LEO73_RS14030	COG0067	glutamate synthase
LEO73_RS14030	COG0069	glutamate synthase activity
LEO73_RS14030	COG0070	glutamate synthase
LEO73_RS14035	COG0493	'glutamate synthase
LEO73_RS14050	COG0789	Transcriptional regulator
LEO73_RS14065	COG4104	PAAR repeat-containing protein
LEO73_RS14075	COG0513	Belongs to the DEAD box helicase family
LEO73_RS14080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LEO73_RS14130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LEO73_RS14135	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LEO73_RS14140	COG0505	Belongs to the CarA family
LEO73_RS14145	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LEO73_RS14155	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LEO73_RS14160	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LEO73_RS14165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LEO73_RS14170	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LEO73_RS14175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEO73_RS14180	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
LEO73_RS14190	COG2205	protein histidine kinase activity
LEO73_RS14190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO73_RS14230	COG0023	Translation Initiation Factor
LEO73_RS14235	COG2119	membrane
LEO73_RS14265	COG2199	diguanylate cyclase activity
LEO73_RS14265	COG2203	Gaf domain
LEO73_RS14295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LEO73_RS14305	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEO73_RS14310	COG3301	Polysulphide reductase, NrfD
LEO73_RS14315	COG0437	4 iron, 4 sulfur cluster binding
LEO73_RS14320	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
LEO73_RS14385	COG0322	excinuclease ABC activity
LEO73_RS14390	COG2197	response regulator
LEO73_RS14395	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LEO73_RS14400	COG2835	tetraacyldisaccharide 4'-kinase activity
LEO73_RS14405	COG1663	tetraacyldisaccharide 4'-kinase activity
LEO73_RS14415	COG2333	competence protein COMEC
LEO73_RS14415	COG0658	competence protein
LEO73_RS14430	COG0433	COG0433 Predicted ATPase
LEO73_RS14435	COG1448	Aminotransferase
LEO73_RS14450	COG1199	ATP-dependent helicase activity
LEO73_RS14460	COG0123	including yeast histone deacetylase and acetoin utilization protein
LEO73_RS14465	COG0477	Major facilitator Superfamily
LEO73_RS14470	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LEO73_RS14495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LEO73_RS14510	COG2271	Major facilitator Superfamily
LEO73_RS14515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO73_RS14520	COG0765	amino acid transport
LEO73_RS14545	COG0531	amino acid
LEO73_RS14560	COG1253	flavin adenine dinucleotide binding
LEO73_RS14565	COG0704	Plays a role in the regulation of phosphate uptake
LEO73_RS14570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LEO73_RS14575	COG0581	inorganic phosphate transmembrane transporter activity
LEO73_RS14580	COG0573	inorganic phosphate transmembrane transporter activity
LEO73_RS14585	COG0590	tRNA wobble adenosine to inosine editing
LEO73_RS14600	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LEO73_RS14620	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LEO73_RS14625	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LEO73_RS14630	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LEO73_RS14635	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LEO73_RS14660	COG2716	regulation of RNA biosynthetic process
LEO73_RS14665	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LEO73_RS14675	COG2239	Acts as a magnesium transporter
LEO73_RS14690	COG3951	Flagellar rod assembly protein muramidase FlgJ
LEO73_RS14690	COG1705	Flagellar rod assembly protein muramidase FlgJ
LEO73_RS14695	COG1706	bacterial-type flagellum-dependent cell motility
LEO73_RS14700	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LEO73_RS14710	COG4787	bacterial-type flagellum-dependent cell motility
LEO73_RS14730	COG1815	bacterial-type flagellum-dependent cell motility
LEO73_RS14735	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LEO73_RS14740	COG0784	Response regulator, receiver
LEO73_RS14740	COG0835	chemotaxis
LEO73_RS14745	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
LEO73_RS14760	COG0622	Phosphoesterase
LEO73_RS14765	COG4166	transmembrane transport
LEO73_RS14790	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LEO73_RS14795	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LEO73_RS14800	COG1882	Formate acetyltransferase
LEO73_RS14805	COG1349	DNA-binding transcription factor activity
LEO73_RS14810	COG0697	spore germination
LEO73_RS14815	COG4166	transmembrane transport
LEO73_RS14840	COG1278	Cold shock
LEO73_RS14860	COG2988	succinylglutamate desuccinylase activity
LEO73_RS14880	COG3132	Protein of unknown function, DUF480
LEO73_RS14890	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LEO73_RS14910	COG0489	protein tyrosine kinase activity
LEO73_RS14910	COG3206	protein involved in exopolysaccharide biosynthesis
LEO73_RS14915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LEO73_RS14920	COG1596	polysaccharide export
LEO73_RS14960	COG0438	transferase activity, transferring glycosyl groups
LEO73_RS14965	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LEO73_RS14970	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LEO73_RS14975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LEO73_RS14985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LEO73_RS15000	COG1051	belongs to the nudix hydrolase family
LEO73_RS15030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LEO73_RS15035	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LEO73_RS15040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LEO73_RS15055	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LEO73_RS15060	COG1091	dTDP-4-dehydrorhamnose reductase activity
LEO73_RS15075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO73_RS15080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO73_RS15085	COG1309	transcriptional regulator
LEO73_RS15105	COG1946	Acyl-CoA thioesterase
LEO73_RS15115	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LEO73_RS15125	COG0009	L-threonylcarbamoyladenylate synthase
LEO73_RS15135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LEO73_RS15140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LEO73_RS15140	COG0512	Glutamine amidotransferase of anthranilate synthase
LEO73_RS15145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LEO73_RS15150	COG0134	indole-3-glycerol-phosphate synthase activity
LEO73_RS15150	COG0135	phosphoribosylanthranilate isomerase activity
LEO73_RS15155	COG0133	tryptophan synthase activity
LEO73_RS15160	COG0159	tryptophan synthase activity
LEO73_RS15170	COG1988	membrane-bound metal-dependent
LEO73_RS15175	COG1396	sequence-specific DNA binding
LEO73_RS15180	COG3550	peptidyl-serine autophosphorylation
LEO73_RS15200	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEO73_RS15210	COG4521	taurine ABC transporter
LEO73_RS15215	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LEO73_RS15220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LEO73_RS15225	COG2175	clavaminate synthase activity
LEO73_RS15235	COG2814	Major facilitator Superfamily
LEO73_RS15240	COG0109	protoheme IX farnesyltransferase activity
LEO73_RS15245	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LEO73_RS15250	COG1845	cytochrome c oxidase, subunit III
LEO73_RS15255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LEO73_RS15260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LEO73_RS15265	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LEO73_RS15310	COG2211	Major facilitator Superfamily
LEO73_RS15315	COG0071	Belongs to the small heat shock protein (HSP20) family
LEO73_RS15330	COG0708	Exodeoxyribonuclease III
LEO73_RS15355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO73_RS15360	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO73_RS15380	COG0095	Lipoate-protein ligase
LEO73_RS15410	COG0640	Transcriptional regulator
LEO73_RS15425	COG1285	pathogenesis
LEO73_RS15455	COG0484	heat shock protein binding
LEO73_RS15460	COG0443	Heat shock 70 kDa protein
LEO73_RS15465	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LEO73_RS15470	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LEO73_RS15475	COG0497	DNA recombination
LEO73_RS15480	COG1227	inorganic diphosphatase activity
LEO73_RS15490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO73_RS15495	COG0577	efflux transmembrane transporter activity
LEO73_RS15495	COG1136	(ABC) transporter
LEO73_RS15505	COG2375	cellular response to nickel ion
LEO73_RS15510	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEO73_RS15535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO73_RS15540	COG1917	Cupin 2, conserved barrel domain protein
LEO73_RS15540	COG1396	sequence-specific DNA binding
LEO73_RS15555	COG0531	amino acid
LEO73_RS15565	COG0531	amino acid
LEO73_RS15575	COG1283	sodium-dependent phosphate transmembrane transporter activity
LEO73_RS15585	COG3384	dioxygenase
LEO73_RS15590	COG5002	protein histidine kinase activity
LEO73_RS15590	COG0784	Response regulator, receiver
LEO73_RS15590	COG2205	protein histidine kinase activity
LEO73_RS15595	COG4251	negative regulation of phosphorylation
LEO73_RS15595	COG5001	Diguanylate cyclase
LEO73_RS15595	COG3706	GGDEF domain
LEO73_RS15595	COG2203	Gaf domain
LEO73_RS15600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO73_RS15600	COG2205	protein histidine kinase activity
LEO73_RS15620	COG0488	(ABC) transporter
LEO73_RS15635	COG4319	ketosteroid isomerase
LEO73_RS15640	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LEO73_RS15645	COG0083	homoserine kinase activity
LEO73_RS15655	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LEO73_RS15660	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LEO73_RS15675	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LEO73_RS15685	COG0745	RESPONSE REGULATOR receiver
LEO73_RS15700	COG4988	ABC transporter
LEO73_RS15705	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LEO73_RS15725	COG1720	tRNA m6t6A37 methyltransferase activity
LEO73_RS15730	COG2770	Histidine kinase
LEO73_RS15730	COG3437	response regulator, receiver
LEO73_RS15745	COG0542	response to heat
LEO73_RS15750	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LEO73_RS15755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO73_RS15760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LEO73_RS15765	COG2190	(PTS) system
LEO73_RS15775	COG3038	cytochrome b561
LEO73_RS15785	COG0420	3'-5' exonuclease activity
LEO73_RS15795	COG2974	May be involved in recombination
LEO73_RS15805	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LEO73_RS15805	COG4651	solute:proton antiporter activity
LEO73_RS15820	COG0469	pyruvate kinase activity
LEO73_RS15825	COG1196	nuclear chromosome segregation
LEO73_RS15825	COG3264	Mechanosensitive ion channel
LEO73_RS15835	COG2706	6-phosphogluconolactonase activity
LEO73_RS15850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO73_RS15870	COG0281	malic enzyme
LEO73_RS15880	COG0437	4 iron, 4 sulfur cluster binding
LEO73_RS15885	COG3383	formate dehydrogenase (NAD+) activity
LEO73_RS15885	COG3383	formate dehydrogenase (NAD+) activity
LEO73_RS15920	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LEO73_RS15925	COG1910	domain protein
LEO73_RS15930	COG3852	Histidine kinase
LEO73_RS15945	COG4662	Binding-protein-dependent transport system inner membrane component
LEO73_RS15955	COG0746	molybdenum cofactor guanylyltransferase activity
LEO73_RS15960	COG0303	'Molybdopterin
LEO73_RS15965	COG1289	transmembrane transporter activity
LEO73_RS15970	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEO73_RS16000	COG3220	belongs to the UPF0276 family
LEO73_RS16040	COG0784	Response regulator, receiver
LEO73_RS16040	COG2205	protein histidine kinase activity
LEO73_RS16045	COG4166	transmembrane transport
LEO73_RS16050	COG0601	transmembrane transport
LEO73_RS16055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEO73_RS16060	COG0444	Belongs to the ABC transporter superfamily
LEO73_RS16065	COG4608	Belongs to the ABC transporter superfamily
LEO73_RS16075	COG2971	BadF BadG BcrA BcrD
LEO73_RS16085	COG0840	transmembrane signaling receptor activity
LEO73_RS16105	COG3724	N-succinylarginine dihydrolase activity
LEO73_RS16110	COG0616	signal peptide processing
LEO73_RS16115	COG1028	Short-chain dehydrogenase reductase Sdr
LEO73_RS16120	COG0583	DNA-binding transcription factor activity
LEO73_RS16130	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LEO73_RS16140	COG0583	DNA-binding transcription factor activity
LEO73_RS16145	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LEO73_RS16150	COG1881	PFAM PEBP family protein
LEO73_RS16160	COG3408	Glycogen debranching enzyme
LEO73_RS16160	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
LEO73_RS16165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LEO73_RS16170	COG0739	heme binding
LEO73_RS16175	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LEO73_RS16195	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LEO73_RS16205	COG3091	SprT-like family
LEO73_RS16215	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LEO73_RS16220	COG0189	ligase activity
LEO73_RS16230	COG1678	Uncharacterized ACR, COG1678
LEO73_RS16235	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LEO73_RS16240	COG3104	oligopeptide transport
LEO73_RS16250	COG0714	Associated with various cellular activities
LEO73_RS16265	COG1115	amino acid carrier protein
LEO73_RS16270	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LEO73_RS16285	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LEO73_RS16295	COG1301	dicarboxylic acid transport
LEO73_RS16300	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LEO73_RS16305	COG2912	Transglutaminase-like superfamily
LEO73_RS16315	COG2890	protein-(glutamine-N5) methyltransferase activity
LEO73_RS16320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LEO73_RS16325	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LEO73_RS16330	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LEO73_RS16335	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LEO73_RS16345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LEO73_RS16350	COG0737	Belongs to the 5'-nucleotidase family
LEO73_RS16355	COG0193	aminoacyl-tRNA hydrolase activity
LEO73_RS16360	COG0012	GTP binding
LEO73_RS16405	COG0471	metal ion transport
LEO73_RS16405	COG0490	domain, Protein
LEO73_RS16415	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
LEO73_RS16425	COG3097	Belongs to the UPF0267 family
LEO73_RS16435	COG0366	Alpha amylase catalytic
LEO73_RS16445	COG0488	(ABC) transporter
LEO73_RS16475	COG0674	pyruvate-flavodoxin oxidoreductase activity
LEO73_RS16475	COG1013	pyruvate-flavodoxin oxidoreductase activity
LEO73_RS16475	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LEO73_RS16475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO73_RS16485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO73_RS16495	COG1012	belongs to the aldehyde dehydrogenase family
LEO73_RS16505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LEO73_RS16520	COG0180	Tryptophanyl-tRNA synthetase
LEO73_RS16530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LEO73_RS16540	COG0338	D12 class N6 adenine-specific DNA methyltransferase
LEO73_RS16550	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LEO73_RS16555	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LEO73_RS16585	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LEO73_RS16590	COG0583	DNA-binding transcription factor activity
LEO73_RS16595	COG0840	transmembrane signaling receptor activity
LEO73_RS16610	COG0583	DNA-binding transcription factor activity
LEO73_RS16625	COG0739	heme binding
LEO73_RS16635	COG1511	domain protein
LEO73_RS16635	COG3264	Mechanosensitive ion channel
LEO73_RS16640	COG0584	glycerophosphoryl diester phosphodiesterase
LEO73_RS16650	COG1053	succinate dehydrogenase
LEO73_RS16655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LEO73_RS16660	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LEO73_RS16670	COG3366	ferrous iron transmembrane transporter activity
LEO73_RS16675	COG0700	Nucleoside recognition
LEO73_RS16680	COG2195	Cleaves the N-terminal amino acid of tripeptides
LEO73_RS16690	COG3214	Protein conserved in bacteria
LEO73_RS16730	COG0642	Histidine kinase
LEO73_RS16740	COG0516	GMP reductase activity
LEO73_RS16750	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LEO73_RS16755	COG3647	Membrane
LEO73_RS16765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LEO73_RS16785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO73_RS16800	COG3706	GGDEF domain
LEO73_RS16810	COG1335	isochorismatase
LEO73_RS16815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LEO73_RS16820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LEO73_RS16825	COG1702	phosphate starvation-inducible protein PhoH
LEO73_RS16830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LEO73_RS16835	COG4535	Mg2 and Co2 transporter CorC
LEO73_RS16840	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LEO73_RS16845	COG2888	peptidyl-tyrosine sulfation
LEO73_RS16850	COG0495	leucyl-tRNA aminoacylation
LEO73_RS16865	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LEO73_RS16870	COG0799	negative regulation of ribosome biogenesis
LEO73_RS16875	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LEO73_RS16880	COG0768	penicillin binding
LEO73_RS16885	COG0772	Belongs to the SEDS family
LEO73_RS16890	COG2951	lytic endotransglycosylase activity
LEO73_RS16895	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LEO73_RS16900	COG1686	Belongs to the peptidase S11 family
LEO73_RS16905	COG2921	Belongs to the UPF0250 family
LEO73_RS16910	COG0321	lipoyl(octanoyl) transferase activity
LEO73_RS16915	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LEO73_RS16920	COG3545	Serine hydrolase
LEO73_RS16940	COG0789	Transcriptional regulator
LEO73_RS16945	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LEO73_RS16955	COG1970	mechanosensitive ion channel activity
LEO73_RS16965	COG4974	Belongs to the 'phage' integrase family
LEO73_RS16975	COG0312	modulator of DNA gyrase
LEO73_RS16980	COG0312	modulator of DNA gyrase
LEO73_RS17050	COG0114	fumarate hydratase activity
LEO73_RS17060	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LEO73_RS17065	COG3706	GGDEF domain
LEO73_RS17070	COG2211	Major facilitator Superfamily
LEO73_RS17075	COG1185	polyribonucleotide nucleotidyltransferase activity
LEO73_RS17080	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LEO73_RS17085	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LEO73_RS17090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LEO73_RS17095	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LEO73_RS17100	COG0195	Participates in both transcription termination and antitermination
LEO73_RS17105	COG0779	Required for maturation of 30S ribosomal subunits
LEO73_RS17120	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LEO73_RS17125	COG0149	triose-phosphate isomerase activity
LEO73_RS17130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LEO73_RS17135	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LEO73_RS17145	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LEO73_RS17150	COG1534	Rna-binding protein
LEO73_RS17165	COG1360	Flagellar Motor Protein
LEO73_RS17170	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LEO73_RS17175	COG1722	exodeoxyribonuclease VII activity
LEO73_RS17180	COG0142	geranyltranstransferase activity
LEO73_RS17185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LEO73_RS17190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEO73_RS17195	COG0601	transmembrane transport
LEO73_RS17205	COG4172	Belongs to the ABC transporter superfamily
LEO73_RS17210	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LEO73_RS17215	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LEO73_RS17220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LEO73_RS17240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LEO73_RS17240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LEO73_RS17245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LEO73_RS17260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LEO73_RS17270	COG0784	Response regulator, receiver
LEO73_RS17270	COG2198	Histidine kinase
LEO73_RS17270	COG2205	protein histidine kinase activity
LEO73_RS17275	COG1879	ABC-type sugar transport system periplasmic component
LEO73_RS17285	COG0745	RESPONSE REGULATOR receiver
LEO73_RS17290	COG3005	denitrification pathway
LEO73_RS17300	COG3381	protein complex oligomerization
LEO73_RS17320	COG3300	MHYT domain
LEO73_RS17320	COG5001	Diguanylate cyclase
LEO73_RS17330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LEO73_RS17335	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LEO73_RS17340	COG0511	ligase activity, forming carbon-carbon bonds
LEO73_RS17345	COG0439	Biotin carboxylase
LEO73_RS17350	COG3924	membrane
LEO73_RS17355	COG4145	pantothenate transmembrane transporter activity
LEO73_RS17360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO73_RS17360	COG2190	(PTS) system
LEO73_RS17360	COG1263	PTS System
LEO73_RS17365	COG0583	DNA-binding transcription factor activity
LEO73_RS17370	COG0604	alcohol dehydrogenase
LEO73_RS17375	COG2264	protein methyltransferase activity
LEO73_RS17390	COG0778	Nitroreductase
LEO73_RS17395	COG1902	pentaerythritol trinitrate reductase activity
LEO73_RS17395	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO73_RS17400	COG0616	signal peptide processing
LEO73_RS17420	COG3139	Protein of unknown function (DUF1315)
LEO73_RS17425	COG0252	asparaginase activity
LEO73_RS17430	COG0786	glutamate:sodium symporter activity
LEO73_RS17445	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LEO73_RS17450	COG0384	phenazine biosynthesis protein PhzF
LEO73_RS17455	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LEO73_RS17460	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LEO73_RS17465	COG0175	sulfate reduction
LEO73_RS17470	COG2113	Glycine betaine
LEO73_RS17480	COG4175	Glycine betaine
LEO73_RS17490	COG3610	response to peptide
LEO73_RS17495	COG2966	Psort location CytoplasmicMembrane, score
LEO73_RS17505	COG0521	Mo-molybdopterin cofactor biosynthetic process
LEO73_RS17515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LEO73_RS17520	COG1028	Short-chain dehydrogenase reductase Sdr
LEO73_RS17530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LEO73_RS17555	COG2986	histidine ammonia-lyase
LEO73_RS17580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LEO73_RS17585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LEO73_RS17620	COG1858	cytochrome C peroxidase
LEO73_RS17630	COG2313	pseudouridylate synthase activity
LEO73_RS17635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO73_RS17680	COG1073	alpha beta
LEO73_RS17685	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LEO73_RS17690	COG2195	Cleaves the N-terminal amino acid of tripeptides
LEO73_RS17695	COG4608	Belongs to the ABC transporter superfamily
LEO73_RS17700	COG0444	Belongs to the ABC transporter superfamily
LEO73_RS17710	COG4239	(ABC) transporter, permease
LEO73_RS17715	COG4174	ABC transporter (Permease)
LEO73_RS17730	COG0811	peptide transport
LEO73_RS17735	COG0811	peptide transport
LEO73_RS17740	COG0848	biopolymer transport protein
LEO73_RS17790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LEO73_RS17795	COG0840	transmembrane signaling receptor activity
LEO73_RS17805	COG1278	Cold shock
LEO73_RS17840	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LEO73_RS17845	COG1162	GTPase activity
LEO73_RS17850	COG0688	phosphatidylethanolamine metabolic process
LEO73_RS17855	COG4628	conserved protein (DUF2132)
LEO73_RS17875	COG3300	MHYT domain
LEO73_RS17875	COG5001	Diguanylate cyclase
LEO73_RS17880	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
LEO73_RS17905	COG1132	(ABC) transporter
LEO73_RS17915	COG1404	Belongs to the peptidase S8 family
LEO73_RS17920	COG2897	thiosulfate sulfurtransferase activity
LEO73_RS17925	COG2066	Belongs to the glutaminase family
LEO73_RS17930	COG3171	Protein conserved in bacteria
LEO73_RS17935	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LEO73_RS17940	COG2234	aminopeptidase activity
LEO73_RS17940	COG4935	Belongs to the peptidase S8 family
LEO73_RS17945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LEO73_RS17950	COG2200	EAL domain
LEO73_RS17955	COG1090	epimerase
LEO73_RS17960	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LEO73_RS17965	COG4181	ATPase activity
LEO73_RS17970	COG2755	lipolytic protein G-D-S-L family
LEO73_RS17975	COG0835	chemotaxis
LEO73_RS17975	COG0784	Response regulator, receiver
LEO73_RS17990	COG3300	MHYT domain
LEO73_RS17990	COG5001	Diguanylate cyclase
LEO73_RS18000	COG0459	protein refolding
LEO73_RS18005	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LEO73_RS18010	COG0534	Mate efflux family protein
LEO73_RS18015	COG3030	protein affecting phage T7 exclusion by the F plasmid
LEO73_RS18020	COG1027	Aspartate ammonia-lyase
LEO73_RS18025	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LEO73_RS18035	COG0477	Major facilitator Superfamily
LEO73_RS18045	COG3227	Zinc metalloprotease (Elastase)
LEO73_RS18050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LEO73_RS18055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LEO73_RS18065	COG0673	inositol 2-dehydrogenase activity
LEO73_RS18075	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LEO73_RS18080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LEO73_RS18085	COG3036	rescue of stalled ribosome
LEO73_RS18100	COG0138	bifunctional purine biosynthesis protein purh
LEO73_RS18125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LEO73_RS18130	COG0358	DNA primase activity
LEO73_RS18135	COG1610	YqeY-like protein
LEO73_RS18140	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LEO73_RS18145	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LEO73_RS18160	COG1238	metal cluster binding
LEO73_RS18165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LEO73_RS18170	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LEO73_RS18175	COG0585	pseudouridine synthase activity
LEO73_RS18185	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LEO73_RS18190	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LEO73_RS18195	COG0148	phosphopyruvate hydratase activity
LEO73_RS18200	COG0504	CTP synthase activity
LEO73_RS18205	COG3956	TIGRFAM MazG family protein
LEO73_RS18210	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LEO73_RS18215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LEO73_RS18225	COG4807	Protein conserved in bacteria
LEO73_RS18230	COG3023	N-Acetylmuramoyl-L-alanine amidase
LEO73_RS18235	COG1349	DNA-binding transcription factor activity
LEO73_RS18245	COG2222	sugar isomerase
LEO73_RS18250	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO73_RS18260	COG3716	PTS system mannose fructose sorbose family IID component
LEO73_RS18265	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO73_RS18270	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LEO73_RS18280	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LEO73_RS18285	COG1381	Involved in DNA repair and RecF pathway recombination
LEO73_RS18295	COG0571	ribonuclease III activity
LEO73_RS18300	COG0681	Belongs to the peptidase S26 family
LEO73_RS18305	COG0481	GTPase activity
LEO73_RS18320	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
LEO73_RS18325	COG1595	DNA-templated transcription, initiation
LEO73_RS18330	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LEO73_RS18340	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LEO73_RS18345	COG0354	folic acid binding
LEO73_RS18390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO73_RS18400	COG0126	phosphoglycerate kinase activity
LEO73_RS18405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LEO73_RS18410	COG1940	carbohydrate kinase activity
LEO73_RS18415	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LEO73_RS18420	COG2816	NAD+ diphosphatase activity
LEO73_RS18430	COG4991	sh3 domain protein
LEO73_RS18435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEO73_RS18450	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LEO73_RS18455	COG1028	Short-chain dehydrogenase reductase Sdr
LEO73_RS18465	COG2982	Protein involved in outer membrane biogenesis
LEO73_RS18470	COG1505	serine-type exopeptidase activity
LEO73_RS18475	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LEO73_RS18480	COG0765	amino acid transport
LEO73_RS18485	COG0765	amino acid transport
LEO73_RS18490	COG1126	abc transporter atp-binding protein
LEO73_RS18495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO73_RS18500	COG0577	efflux transmembrane transporter activity
LEO73_RS18500	COG1136	(ABC) transporter
LEO73_RS18505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO73_RS18510	COG0745	RESPONSE REGULATOR receiver
LEO73_RS18515	COG2205	protein histidine kinase activity
LEO73_RS18550	COG2070	2-Nitropropane dioxygenase
LEO73_RS18575	COG1858	cytochrome C peroxidase
LEO73_RS18580	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
LEO73_RS18600	COG0513	Belongs to the DEAD box helicase family
LEO73_RS18610	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LEO73_RS18615	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LEO73_RS18640	COG2957	Belongs to the agmatine deiminase family
LEO73_RS18650	COG2852	Protein conserved in bacteria
LEO73_RS18660	COG1902	pentaerythritol trinitrate reductase activity
LEO73_RS18670	COG0456	acetyltransferase
LEO73_RS18690	COG5001	Diguanylate cyclase
LEO73_RS18690	COG3300	MHYT domain
LEO73_RS18720	COG0456	acetyltransferase
LEO73_RS18730	COG1022	Amp-dependent synthetase and ligase
LEO73_RS18735	COG2918	glutathione biosynthetic process
LEO73_RS18740	COG0612	Peptidase, M16
LEO73_RS18745	COG1238	metal cluster binding
LEO73_RS18775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LEO73_RS18780	COG0359	binds to the 23S rRNA
LEO73_RS18785	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LEO73_RS18790	COG0360	Binds together with S18 to 16S ribosomal RNA
LEO73_RS18795	COG1914	H( )-stimulated, divalent metal cation uptake system
LEO73_RS18805	COG0583	DNA-binding transcription factor activity
LEO73_RS18815	COG2814	Major facilitator Superfamily
LEO73_RS18835	COG0697	spore germination
LEO73_RS18840	COG2153	protein acetylation
LEO73_RS18850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LEO73_RS18875	COG0557	exoribonuclease II activity
LEO73_RS18880	COG3706	GGDEF domain
LEO73_RS18885	COG1854	S-ribosylhomocysteine lyase activity
LEO73_RS18900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LEO73_RS18900	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LEO73_RS18960	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LEO73_RS18965	COG1047	Peptidyl-prolyl cis-trans
LEO73_RS18970	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LEO73_RS18975	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LEO73_RS18980	COG0196	riboflavin kinase activity
LEO73_RS18985	COG0728	peptidoglycan biosynthetic process
LEO73_RS18990	COG0268	Binds directly to 16S ribosomal RNA
LEO73_RS18995	COG0640	Transcriptional regulator
LEO73_RS19000	COG0583	DNA-binding transcription factor activity
LEO73_RS19010	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LEO73_RS19015	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LEO73_RS19020	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LEO73_RS19030	COG1051	belongs to the nudix hydrolase family
LEO73_RS19035	COG3066	DNA modification
LEO73_RS19045	COG0335	large ribosomal subunit rRNA binding
LEO73_RS19050	COG0336	Belongs to the RNA methyltransferase TrmD family
LEO73_RS19055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LEO73_RS19060	COG0228	four-way junction DNA binding
LEO73_RS19065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LEO73_RS19070	COG4137	Cytochrome C assembly protein
LEO73_RS19075	COG4536	flavin adenine dinucleotide binding
LEO73_RS19080	COG1959	2 iron, 2 sulfur cluster binding
LEO73_RS19085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LEO73_RS19085	COG1017	nitric oxide dioxygenase activity
LEO73_RS19090	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
LEO73_RS19095	COG0039	L-malate dehydrogenase activity
LEO73_RS19100	COG4160	amino acid transport
LEO73_RS19105	COG4215	(ABC) transporter
LEO73_RS19110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO73_RS19115	COG1126	abc transporter atp-binding protein
LEO73_RS19120	COG1438	arginine binding
LEO73_RS19125	COG2837	iron assimilation
LEO73_RS19130	COG3842	ATPase activity
LEO73_RS19140	COG1840	ABC-type Fe3 transport system, periplasmic component
LEO73_RS19145	COG0347	Belongs to the P(II) protein family
LEO73_RS19160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEO73_RS19165	COG0583	DNA-binding transcription factor activity
LEO73_RS19180	COG1929	Belongs to the glycerate kinase type-1 family
LEO73_RS19185	COG2610	gluconate transmembrane transporter activity
LEO73_RS19190	COG3835	regulator
LEO73_RS19195	COG3112	Uncharacterised protein family (UPF0231)
LEO73_RS19225	COG0513	Belongs to the DEAD box helicase family
LEO73_RS19265	COG1448	Aminotransferase
LEO73_RS19280	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LEO73_RS19285	COG1328	CTP reductase activity
LEO73_RS19305	COG4946	Tricorn protease homolog
LEO73_RS19305	COG0793	Belongs to the peptidase S41A family
LEO73_RS19340	COG3397	chitin binding
LEO73_RS19345	COG0583	DNA-binding transcription factor activity
LEO73_RS19350	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LEO73_RS19355	COG4208	sulfate ABC transporter
LEO73_RS19360	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LEO73_RS19370	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LEO73_RS19375	COG3174	membrane
LEO73_RS19380	COG0110	maltose O-acetyltransferase activity
LEO73_RS19405	COG0165	Argininosuccinate lyase
LEO73_RS19410	COG0137	argininosuccinate synthase activity
LEO73_RS19420	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LEO73_RS19425	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LEO73_RS19435	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LEO73_RS19440	COG0460	homoserine dehydrogenase
LEO73_RS19440	COG0527	aspartate kinase activity
LEO73_RS19445	COG0626	cystathionine gamma-synthase activity
LEO73_RS19455	COG2207	Transcriptional regulator
LEO73_RS19455	COG3708	Transcriptional regulator
LEO73_RS19460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO73_RS19465	COG0814	amino acid
LEO73_RS19470	COG1218	3'(2'),5'-bisphosphate nucleotidase
LEO73_RS19475	COG0494	nUDIX hydrolase
LEO73_RS19480	COG1011	Hydrolase
LEO73_RS19485	COG1902	pentaerythritol trinitrate reductase activity
LEO73_RS19495	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LEO73_RS19510	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LEO73_RS19520	COG3156	type II secretion system protein K
LEO73_RS19530	COG4795	General secretion pathway protein
LEO73_RS19535	COG2165	general secretion pathway protein
LEO73_RS19545	COG2165	general secretion pathway protein
LEO73_RS19550	COG1459	type II secretion system
LEO73_RS19555	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LEO73_RS19565	COG3031	protein transport across the cell outer membrane
LEO73_RS19575	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LEO73_RS19580	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LEO73_RS19600	COG0456	acetyltransferase
LEO73_RS19605	COG3133	Outer membrane lipoprotein
LEO73_RS19620	COG2771	luxR family
LEO73_RS19625	COG3916	Acyl-homoserine-lactone synthase
LEO73_RS19635	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LEO73_RS19640	COG1309	transcriptional regulator
LEO73_RS19650	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO73_RS19650	COG2213	PTS system mannitol-specific
LEO73_RS19655	COG0246	Mannitol dehydrogenase
LEO73_RS19660	COG3722	fumarate hydratase activity
LEO73_RS19665	COG3263	regulation of cellular component size
LEO73_RS19690	COG1671	Belongs to the UPF0178 family
LEO73_RS19705	COG1988	membrane-bound metal-dependent
LEO73_RS19710	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEO73_RS19715	COG0513	Belongs to the DEAD box helicase family
LEO73_RS19740	COG1575	Belongs to the MenA family. Type 1 subfamily
LEO73_RS19745	COG1169	isochorismate synthase
LEO73_RS19750	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LEO73_RS19755	COG0596	Alpha beta hydrolase
LEO73_RS19760	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LEO73_RS19765	COG1441	menaquinone biosynthetic process
LEO73_RS19770	COG0318	PFAM AMP-dependent synthetase and ligase
LEO73_RS19790	COG3121	Chaperone
LEO73_RS19795	COG3188	usher protein
LEO73_RS19805	COG3539	Fimbrial protein
LEO73_RS19815	COG3291	Pkd domain containing protein
LEO73_RS19820	COG2949	membrane
LEO73_RS19825	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LEO73_RS19835	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LEO73_RS19840	COG5380	lipid catabolic process
LEO73_RS19865	COG2873	o-acetylhomoserine
LEO73_RS19875	COG1979	alcohol dehydrogenase
LEO73_RS19890	COG4221	oxidoreductase activity
LEO73_RS19910	COG1285	pathogenesis
LEO73_RS19930	COG1368	sulfuric ester hydrolase activity
LEO73_RS19935	COG1522	sequence-specific DNA binding
LEO73_RS19945	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LEO73_RS19950	COG1418	mRNA catabolic process
LEO73_RS19955	COG1546	Belongs to the CinA family
LEO73_RS19955	COG1058	Belongs to the CinA family
LEO73_RS19965	COG1129	ABC transporter
LEO73_RS19965	COG0842	Transport permease protein
LEO73_RS19980	COG0561	phosphatase activity
LEO73_RS19985	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LEO73_RS20005	COG1011	Hydrolase
LEO73_RS20020	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LEO73_RS20025	COG0019	diaminopimelate decarboxylase activity
LEO73_RS20035	COG1965	Belongs to the frataxin family
LEO73_RS20040	COG0400	carboxylic ester hydrolase activity
LEO73_RS20045	COG3072	Adenylate cyclase
LEO73_RS20050	COG0181	hydroxymethylbilane synthase activity
LEO73_RS20060	COG2959	enzyme of heme biosynthesis
LEO73_RS20075	COG1494	fructose-1,6-bisphosphatase
LEO73_RS20110	COG0456	acetyltransferase
LEO73_RS20115	COG1733	regulation of RNA biosynthetic process
LEO73_RS20135	COG3932	Exopolysaccharide synthesis, ExoD
LEO73_RS20140	COG0814	amino acid
LEO73_RS20145	COG3706	GGDEF domain
LEO73_RS20165	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
LEO73_RS20175	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LEO73_RS20180	COG2022	thiamine diphosphate biosynthetic process
LEO73_RS20190	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LEO73_RS20195	COG0352	thiamine-phosphate diphosphorylase activity
LEO73_RS20200	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LEO73_RS20220	COG0745	RESPONSE REGULATOR receiver
LEO73_RS20225	COG0642	Histidine kinase
LEO73_RS20235	COG0189	ligase activity
LEO73_RS20255	COG0582	viral genome integration into host DNA
LEO73_RS20290	COG1715	Restriction endonuclease
LEO73_RS20300	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LEO73_RS20340	COG1639	'signal transduction protein
LEO73_RS20350	COG2321	neutral zinc metallopeptidase
LEO73_RS20355	COG3700	Belongs to the class B bacterial acid phosphatase family
LEO73_RS20375	COG1366	Belongs to the anti-sigma-factor antagonist family
LEO73_RS20385	COG2205	protein histidine kinase activity
LEO73_RS20385	COG5002	protein histidine kinase activity
LEO73_RS20385	COG0784	Response regulator, receiver
LEO73_RS20390	COG3437	response regulator, receiver
LEO73_RS20415	COG0312	modulator of DNA gyrase
LEO73_RS20420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LEO73_RS20430	COG3164	Protein of unknown function
LEO73_RS20435	COG1530	ribonuclease E activity
LEO73_RS20440	COG0424	maF-like protein
LEO73_RS20445	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LEO73_RS20450	COG1792	Involved in formation and maintenance of cell shape
LEO73_RS20455	COG1077	Cell shape determining protein MreB Mrl
LEO73_RS20485	COG2165	general secretion pathway protein
LEO73_RS20490	COG2165	general secretion pathway protein
LEO73_RS20500	COG1459	type II secretion system
LEO73_RS20505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LEO73_RS20550	COG2199	diguanylate cyclase activity
LEO73_RS20550	COG2200	EAL domain
LEO73_RS20555	COG2200	EAL domain
LEO73_RS20560	COG0387	Pfam Sodium calcium exchanger
LEO73_RS20565	COG2986	histidine ammonia-lyase
LEO73_RS20570	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LEO73_RS20575	COG0010	Belongs to the arginase family
LEO73_RS20580	COG1228	amidohydrolase
LEO73_RS20585	COG2188	Transcriptional regulator
LEO73_RS20590	COG0288	reversible hydration of carbon dioxide
LEO73_RS20600	COG2177	Part of the ABC transporter FtsEX involved in
LEO73_RS20605	COG2884	Cell division ATP-binding protein ftsE
LEO73_RS20610	COG0552	protein localization to endoplasmic reticulum
LEO73_RS20615	COG0742	ribosomal rna small subunit methyltransferase
LEO73_RS20640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LEO73_RS20650	COG0741	lytic transglycosylase activity
LEO73_RS20660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LEO73_RS20670	COG2095	MarC family integral membrane protein
LEO73_RS20680	COG1301	dicarboxylic acid transport
LEO73_RS20705	COG3714	YhhN family
LEO73_RS20720	COG2358	TRAP transporter, solute receptor (TAXI family
LEO73_RS20725	COG1770	oligopeptidase
LEO73_RS20740	COG4221	oxidoreductase activity
LEO73_RS20745	COG0583	DNA-binding transcription factor activity
LEO73_RS20750	COG2249	NAD(P)H dehydrogenase (quinone) activity
LEO73_RS20795	COG0203	ribosomal protein L17
LEO73_RS20800	COG0202	RNA polymerase activity
LEO73_RS20805	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LEO73_RS20810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LEO73_RS20815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LEO73_RS20820	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LEO73_RS20825	COG0201	protein transport
LEO73_RS20830	COG0200	Binds to the 23S rRNA
LEO73_RS20835	COG1841	ribosomal large subunit assembly
LEO73_RS20840	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LEO73_RS20845	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LEO73_RS20850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LEO73_RS20855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LEO73_RS20860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LEO73_RS20865	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LEO73_RS20870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LEO73_RS20875	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LEO73_RS20880	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LEO73_RS20885	COG0255	Belongs to the universal ribosomal protein uL29 family
LEO73_RS20890	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LEO73_RS20895	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LEO73_RS20900	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LEO73_RS20905	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LEO73_RS20910	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LEO73_RS20915	COG0089	rRNA binding
LEO73_RS20920	COG0088	Forms part of the polypeptide exit tunnel
LEO73_RS20925	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LEO73_RS20930	COG0051	transcription antitermination factor activity, RNA binding
LEO73_RS20950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LEO73_RS20955	COG2183	response to ionizing radiation
LEO73_RS20975	COG0596	Alpha beta hydrolase
LEO73_RS20980	COG1040	competence protein
LEO73_RS20985	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LEO73_RS20985	COG0316	Belongs to the HesB IscA family
LEO73_RS20990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LEO73_RS20995	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LEO73_RS21000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LEO73_RS21005	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LEO73_RS21010	COG4942	peptidase
LEO73_RS21020	COG1609	Transcriptional regulator
LEO73_RS21025	COG0800	Aldolase
LEO73_RS21030	COG0129	dihydroxy-acid dehydratase activity
LEO73_RS21035	COG3265	gluconokinase activity
LEO73_RS21040	COG2610	gluconate transmembrane transporter activity
LEO73_RS21045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LEO73_RS21050	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LEO73_RS21060	COG0456	acetyltransferase
LEO73_RS21070	COG1490	D-aminoacyl-tRNA deacylase activity
LEO73_RS21075	COG1295	ribonuclease BN
LEO73_RS21080	COG1217	gtp-binding protein TYPA
LEO73_RS21085	COG0174	glutamine synthetase
LEO73_RS21095	COG3852	Histidine kinase
LEO73_RS21100	COG2204	response regulator
LEO73_RS21105	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LEO73_RS21120	COG3078	GTPase activator activity
LEO73_RS21130	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LEO73_RS21140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LEO73_RS21145	COG0408	coproporphyrinogen oxidase activity
LEO73_RS21150	COG0009	L-threonylcarbamoyladenylate synthase
LEO73_RS21160	COG0551	DNA topoisomerase type I activity
LEO73_RS21165	COG2922	Belongs to the Smg family
LEO73_RS21170	COG0758	DNA mediated transformation
LEO73_RS21180	COG0242	peptide deformylase activity
LEO73_RS21185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LEO73_RS21190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LEO73_RS21190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LEO73_RS21195	COG0569	domain protein
LEO73_RS21200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LEO73_RS21205	COG1322	Protein conserved in bacteria
LEO73_RS21225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO73_RS21230	COG0686	Belongs to the AlaDH PNT family
LEO73_RS21235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LEO73_RS21235	COG0519	Catalyzes the synthesis of GMP from XMP
LEO73_RS21245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LEO73_RS21250	COG1396	sequence-specific DNA binding
LEO73_RS21255	COG1012	belongs to the aldehyde dehydrogenase family
LEO73_RS21265	COG2962	Rard protein
LEO73_RS21275	COG1280	lysine exporter protein (LysE YggA)
LEO73_RS21285	COG2391	methyltransferase activity
LEO73_RS21290	COG1280	lysine exporter protein (LysE YggA)
LEO73_RS21325	COG3161	chorismate lyase activity
LEO73_RS21345	COG0583	DNA-binding transcription factor activity
LEO73_RS21370	COG1943	Transposase
LEO73_RS21390	COG0210	DNA helicase
LEO73_RS21400	COG1744	ABC transporter substrate-binding protein PnrA-like
LEO73_RS21405	COG3845	ABC transporter
LEO73_RS21410	COG4603	Belongs to the binding-protein-dependent transport system permease family
LEO73_RS21415	COG1079	Belongs to the binding-protein-dependent transport system permease family
LEO73_RS21420	COG0583	DNA-binding transcription factor activity
LEO73_RS21440	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LEO73_RS21445	COG0385	Bile acid
LEO73_RS21450	COG0531	amino acid
LEO73_RS21455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO73_RS21460	COG0531	amino acid
LEO73_RS21465	COG2731	YhcH YjgK YiaL family protein
LEO73_RS21470	COG3250	beta-galactosidase activity
LEO73_RS21475	COG1609	Transcriptional regulator
LEO73_RS21510	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LEO73_RS21515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEO73_RS21515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEO73_RS21520	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
LEO73_RS21525	COG3074	FtsZ-dependent cytokinesis
LEO73_RS21535	COG1045	serine acetyltransferase
LEO73_RS21545	COG0745	RESPONSE REGULATOR receiver
LEO73_RS21550	COG2205	protein histidine kinase activity
LEO73_RS21555	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LEO73_RS21560	COG0534	Mate efflux family protein
LEO73_RS21575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LEO73_RS21580	COG2937	Belongs to the GPAT DAPAT family
LEO73_RS21585	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LEO73_RS21590	COG3161	chorismate lyase activity
LEO73_RS21595	COG1580	Controls the rotational direction of flagella during chemotaxis
LEO73_RS21610	COG0604	alcohol dehydrogenase
LEO73_RS21615	COG1609	Transcriptional regulator
LEO73_RS21635	COG1519	Transferase
LEO73_RS21640	COG0859	PFAM glycosyl transferase family 9
LEO73_RS21645	COG0463	Glycosyl transferase, family 2
LEO73_RS21650	COG0859	PFAM glycosyl transferase family 9
LEO73_RS21655	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LEO73_RS21660	COG2990	Protein conserved in bacteria
LEO73_RS21665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LEO73_RS21675	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LEO73_RS21680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LEO73_RS21685	COG2003	Belongs to the UPF0758 family
LEO73_RS21690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LEO73_RS21695	COG0756	dUTP diphosphatase activity
LEO73_RS21700	COG1309	transcriptional regulator
LEO73_RS21705	COG0668	transmembrane transport
LEO73_RS21715	COG0166	Belongs to the GPI family
LEO73_RS21720	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LEO73_RS21725	COG0583	DNA-binding transcription factor activity
LEO73_RS21740	COG0045	succinate-CoA ligase (ADP-forming) activity
LEO73_RS21740	COG1042	CoA-binding domain protein
LEO73_RS21740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LEO73_RS21770	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
LEO73_RS21775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LEO73_RS21780	COG1739	Uncharacterized protein family UPF0029
LEO73_RS21785	COG0006	proline dipeptidase activity
LEO73_RS21790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LEO73_RS21795	COG1024	Enoyl-CoA hydratase
LEO73_RS21795	COG1250	3-hydroxyacyl-CoA dehydrogenase
LEO73_RS21800	COG0183	Belongs to the thiolase family
LEO73_RS21825	COG0425	Belongs to the sulfur carrier protein TusA family
LEO73_RS21830	COG0251	oxidation-reduction process
LEO73_RS21840	COG2885	chlorophyll binding
LEO73_RS21850	COG2818	Glycosylase
LEO73_RS21855	COG0752	glycyl-tRNA synthetase alpha subunit
LEO73_RS21860	COG0751	glycine-tRNA ligase activity
LEO73_RS21895	COG0814	amino acid
LEO73_RS21900	COG0348	domain, Protein
LEO73_RS21905	COG2188	Transcriptional regulator
LEO73_RS21920	COG1609	Transcriptional regulator
LEO73_RS21960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LEO73_RS21985	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LEO73_RS22000	COG3118	belongs to the thioredoxin family
LEO73_RS22005	COG0513	Belongs to the DEAD box helicase family
LEO73_RS22010	COG0248	Ppx GppA phosphatase
LEO73_RS22025	COG0742	ribosomal rna small subunit methyltransferase
LEO73_RS22030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO73_RS22050	COG0084	hydrolase, TatD family'
LEO73_RS22055	COG0805	protein transport
LEO73_RS22060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LEO73_RS22070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LEO73_RS22075	COG3165	ubiquinone biosynthetic process from chorismate
LEO73_RS22085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LEO73_RS22090	COG0402	S-adenosylhomocysteine deaminase activity
LEO73_RS22135	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LEO73_RS22140	COG0848	biopolymer transport protein
LEO73_RS22145	COG0811	peptide transport
LEO73_RS22150	COG0811	peptide transport
LEO73_RS22160	COG2771	luxR family
LEO73_RS22230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LEO73_RS22235	COG1349	DNA-binding transcription factor activity
LEO73_RS22240	COG0745	RESPONSE REGULATOR receiver
LEO73_RS22245	COG2205	protein histidine kinase activity
LEO73_RS22255	COG4452	Inner membrane protein CreD
LEO73_RS22260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LEO73_RS22265	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LEO73_RS22270	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LEO73_RS22275	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LEO73_RS22280	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LEO73_RS22285	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LEO73_RS22290	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LEO73_RS22300	COG0356	it plays a direct role in the translocation of protons across the membrane
LEO73_RS22310	COG1475	DNA binding
LEO73_RS22315	COG1192	Involved in chromosome partitioning
LEO73_RS22320	COG0357	Ribosomal RNA small subunit methyltransferase G
LEO73_RS22325	COG0445	tRNA wobble uridine modification
LEO73_RS22330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LEO73_RS22335	COG4774	siderophore transport
LEO73_RS22340	COG4615	Cyclic peptide transporter
LEO73_RS22345	COG1120	ATPase activity
LEO73_RS22360	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LEO73_RS22365	COG0706	membrane insertase activity
LEO73_RS22370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LEO73_RS22375	COG0594	ribonuclease P activity
LEO73_RS22380	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LEO73_RS22385	COG1126	abc transporter atp-binding protein
LEO73_RS22415	COG0583	DNA-binding transcription factor activity