locus-tag	class	description
NRK99_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NRK99_RS00010	COG0592	DNA-directed DNA polymerase activity
NRK99_RS00030	COG2378	regulation of single-species biofilm formation
NRK99_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
NRK99_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
NRK99_RS00045	COG3977	Valine--pyruvate aminotransferase
NRK99_RS00060	COG2814	Major facilitator Superfamily
NRK99_RS00065	COG0745	RESPONSE REGULATOR receiver
NRK99_RS00070	COG2205	protein histidine kinase activity
NRK99_RS00095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NRK99_RS00100	COG4191	Histidine kinase
NRK99_RS00100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRK99_RS00105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRK99_RS00110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRK99_RS00115	COG1309	transcriptional regulator
NRK99_RS00150	COG2271	Major facilitator Superfamily
NRK99_RS00170	COG0561	phosphatase activity
NRK99_RS00175	COG2267	carboxylic ester hydrolase activity
NRK99_RS00185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NRK99_RS00190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NRK99_RS00195	COG1758	RNA polymerase activity
NRK99_RS00205	COG0859	PFAM glycosyl transferase family 9
NRK99_RS00210	COG3642	lipopolysaccharide core region biosynthetic process
NRK99_RS00250	COG0589	response to stress
NRK99_RS00255	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NRK99_RS00265	COG1528	Iron-storage protein
NRK99_RS00270	COG2081	HI0933 family
NRK99_RS00275	COG2223	nitrite transmembrane transporter activity
NRK99_RS00285	COG3275	phosphorelay sensor kinase activity
NRK99_RS00290	COG3279	Response regulator of the LytR AlgR family
NRK99_RS00295	COG2223	nitrite transmembrane transporter activity
NRK99_RS00300	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NRK99_RS00305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NRK99_RS00320	COG0583	DNA-binding transcription factor activity
NRK99_RS00325	COG4206	TonB-dependent receptor
NRK99_RS00330	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NRK99_RS00360	COG0045	succinate-CoA ligase (ADP-forming) activity
NRK99_RS00360	COG1042	CoA-binding domain protein
NRK99_RS00360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRK99_RS00375	COG0583	DNA-binding transcription factor activity
NRK99_RS00380	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NRK99_RS00385	COG0166	Belongs to the GPI family
NRK99_RS00395	COG0668	transmembrane transport
NRK99_RS00400	COG1309	transcriptional regulator
NRK99_RS00405	COG0756	dUTP diphosphatase activity
NRK99_RS00410	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NRK99_RS00415	COG2003	Belongs to the UPF0758 family
NRK99_RS00420	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NRK99_RS00425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NRK99_RS00435	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NRK99_RS00440	COG2990	Protein conserved in bacteria
NRK99_RS00445	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NRK99_RS00450	COG0859	PFAM glycosyl transferase family 9
NRK99_RS00455	COG0463	Glycosyl transferase, family 2
NRK99_RS00460	COG0859	PFAM glycosyl transferase family 9
NRK99_RS00465	COG1519	Transferase
NRK99_RS00485	COG1609	Transcriptional regulator
NRK99_RS00490	COG0604	alcohol dehydrogenase
NRK99_RS00510	COG1580	Controls the rotational direction of flagella during chemotaxis
NRK99_RS00515	COG3161	chorismate lyase activity
NRK99_RS00520	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NRK99_RS00525	COG2937	Belongs to the GPAT DAPAT family
NRK99_RS00530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NRK99_RS00545	COG0534	Mate efflux family protein
NRK99_RS00550	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NRK99_RS00555	COG2205	protein histidine kinase activity
NRK99_RS00560	COG0745	RESPONSE REGULATOR receiver
NRK99_RS00570	COG1045	serine acetyltransferase
NRK99_RS00580	COG3074	FtsZ-dependent cytokinesis
NRK99_RS00585	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
NRK99_RS00590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NRK99_RS00590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NRK99_RS00595	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NRK99_RS00630	COG1609	Transcriptional regulator
NRK99_RS00635	COG3250	beta-galactosidase activity
NRK99_RS00640	COG2731	YhcH YjgK YiaL family protein
NRK99_RS00645	COG0531	amino acid
NRK99_RS00650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRK99_RS00655	COG0531	amino acid
NRK99_RS00660	COG0385	Bile acid
NRK99_RS00665	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NRK99_RS00685	COG0583	DNA-binding transcription factor activity
NRK99_RS00690	COG1079	Belongs to the binding-protein-dependent transport system permease family
NRK99_RS00695	COG4603	Belongs to the binding-protein-dependent transport system permease family
NRK99_RS00700	COG3845	ABC transporter
NRK99_RS00705	COG1744	ABC transporter substrate-binding protein PnrA-like
NRK99_RS00715	COG0210	DNA helicase
NRK99_RS00720	COG0210	DNA helicase
NRK99_RS00745	COG0583	DNA-binding transcription factor activity
NRK99_RS00765	COG3161	chorismate lyase activity
NRK99_RS00800	COG1280	lysine exporter protein (LysE YggA)
NRK99_RS00810	COG2391	methyltransferase activity
NRK99_RS00820	COG1280	lysine exporter protein (LysE YggA)
NRK99_RS00830	COG2962	Rard protein
NRK99_RS00840	COG1012	belongs to the aldehyde dehydrogenase family
NRK99_RS00845	COG1396	sequence-specific DNA binding
NRK99_RS00850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NRK99_RS00860	COG0519	Catalyzes the synthesis of GMP from XMP
NRK99_RS00860	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NRK99_RS00865	COG0686	Belongs to the AlaDH PNT family
NRK99_RS00870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRK99_RS00895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NRK99_RS00900	COG0569	domain protein
NRK99_RS00905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NRK99_RS00905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NRK99_RS00910	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NRK99_RS00915	COG0242	peptide deformylase activity
NRK99_RS00925	COG0758	DNA mediated transformation
NRK99_RS00930	COG2922	Belongs to the Smg family
NRK99_RS00935	COG0551	DNA topoisomerase type I activity
NRK99_RS00945	COG0009	L-threonylcarbamoyladenylate synthase
NRK99_RS00950	COG0408	coproporphyrinogen oxidase activity
NRK99_RS00955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NRK99_RS00965	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NRK99_RS00975	COG3078	GTPase activator activity
NRK99_RS00990	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NRK99_RS00995	COG2204	response regulator
NRK99_RS01000	COG3852	Histidine kinase
NRK99_RS01010	COG0174	glutamine synthetase
NRK99_RS01015	COG1217	gtp-binding protein TYPA
NRK99_RS01020	COG1295	ribonuclease BN
NRK99_RS01030	COG1490	D-aminoacyl-tRNA deacylase activity
NRK99_RS01040	COG0456	acetyltransferase
NRK99_RS01050	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NRK99_RS01055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NRK99_RS01060	COG2610	gluconate transmembrane transporter activity
NRK99_RS01065	COG3265	gluconokinase activity
NRK99_RS01070	COG0129	dihydroxy-acid dehydratase activity
NRK99_RS01075	COG0800	Aldolase
NRK99_RS01080	COG1609	Transcriptional regulator
NRK99_RS01090	COG4942	peptidase
NRK99_RS01095	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NRK99_RS01100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NRK99_RS01105	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
NRK99_RS01110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NRK99_RS01115	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NRK99_RS01115	COG0316	Belongs to the HesB IscA family
NRK99_RS01120	COG1040	competence protein
NRK99_RS01125	COG0596	Alpha beta hydrolase
NRK99_RS01145	COG2183	response to ionizing radiation
NRK99_RS01150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NRK99_RS01170	COG0051	transcription antitermination factor activity, RNA binding
NRK99_RS01175	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NRK99_RS01180	COG0088	Forms part of the polypeptide exit tunnel
NRK99_RS01185	COG0089	rRNA binding
NRK99_RS01190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NRK99_RS01195	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NRK99_RS01200	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NRK99_RS01205	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NRK99_RS01210	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NRK99_RS01215	COG0255	Belongs to the universal ribosomal protein uL29 family
NRK99_RS01220	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NRK99_RS01225	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NRK99_RS01230	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NRK99_RS01235	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NRK99_RS01240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NRK99_RS01245	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NRK99_RS01250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NRK99_RS01255	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NRK99_RS01260	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NRK99_RS01265	COG1841	ribosomal large subunit assembly
NRK99_RS01270	COG0200	Binds to the 23S rRNA
NRK99_RS01275	COG0201	protein transport
NRK99_RS01280	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NRK99_RS01285	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NRK99_RS01290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NRK99_RS01295	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NRK99_RS01300	COG0202	RNA polymerase activity
NRK99_RS01305	COG0203	ribosomal protein L17
NRK99_RS01355	COG2249	NAD(P)H dehydrogenase (quinone) activity
NRK99_RS01360	COG0583	DNA-binding transcription factor activity
NRK99_RS01365	COG4221	oxidoreductase activity
NRK99_RS01380	COG1770	oligopeptidase
NRK99_RS01385	COG2358	TRAP transporter, solute receptor (TAXI family
NRK99_RS01400	COG3714	YhhN family
NRK99_RS01425	COG1301	dicarboxylic acid transport
NRK99_RS01435	COG2095	MarC family integral membrane protein
NRK99_RS01445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NRK99_RS01455	COG0741	lytic transglycosylase activity
NRK99_RS01465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NRK99_RS01490	COG0742	ribosomal rna small subunit methyltransferase
NRK99_RS01495	COG0552	protein localization to endoplasmic reticulum
NRK99_RS01500	COG2884	Cell division ATP-binding protein ftsE
NRK99_RS01505	COG2177	Part of the ABC transporter FtsEX involved in
NRK99_RS01515	COG0288	reversible hydration of carbon dioxide
NRK99_RS01520	COG2188	Transcriptional regulator
NRK99_RS01525	COG1228	amidohydrolase
NRK99_RS01530	COG0010	Belongs to the arginase family
NRK99_RS01535	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NRK99_RS01540	COG2986	histidine ammonia-lyase
NRK99_RS01545	COG0387	Pfam Sodium calcium exchanger
NRK99_RS01550	COG2200	EAL domain
NRK99_RS01555	COG2199	diguanylate cyclase activity
NRK99_RS01555	COG2200	EAL domain
NRK99_RS01600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NRK99_RS01605	COG1459	type II secretion system
NRK99_RS01615	COG2165	general secretion pathway protein
NRK99_RS01650	COG1077	Cell shape determining protein MreB Mrl
NRK99_RS01655	COG1792	Involved in formation and maintenance of cell shape
NRK99_RS01660	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NRK99_RS01665	COG0424	maF-like protein
NRK99_RS01670	COG1530	ribonuclease E activity
NRK99_RS01675	COG3164	Protein of unknown function
NRK99_RS01685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NRK99_RS01690	COG0312	modulator of DNA gyrase
NRK99_RS01705	COG0477	Major facilitator Superfamily
NRK99_RS01715	COG3437	response regulator, receiver
NRK99_RS01720	COG5002	protein histidine kinase activity
NRK99_RS01720	COG2205	protein histidine kinase activity
NRK99_RS01720	COG0784	Response regulator, receiver
NRK99_RS01730	COG1366	Belongs to the anti-sigma-factor antagonist family
NRK99_RS01750	COG3700	Belongs to the class B bacterial acid phosphatase family
NRK99_RS01755	COG2321	neutral zinc metallopeptidase
NRK99_RS01765	COG1639	'signal transduction protein
NRK99_RS01795	COG0189	ligase activity
NRK99_RS01800	COG0642	Histidine kinase
NRK99_RS01805	COG0745	RESPONSE REGULATOR receiver
NRK99_RS01825	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NRK99_RS01830	COG0352	thiamine-phosphate diphosphorylase activity
NRK99_RS01835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NRK99_RS01845	COG2022	thiamine diphosphate biosynthetic process
NRK99_RS01850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NRK99_RS01855	COG2801	Transposase and inactivated derivatives
NRK99_RS01865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRK99_RS01875	COG0110	maltose O-acetyltransferase activity
NRK99_RS01880	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
NRK99_RS01895	COG3706	GGDEF domain
NRK99_RS01900	COG0814	amino acid
NRK99_RS01905	COG3932	Exopolysaccharide synthesis, ExoD
NRK99_RS01925	COG1733	regulation of RNA biosynthetic process
NRK99_RS01930	COG0456	acetyltransferase
NRK99_RS01965	COG1494	fructose-1,6-bisphosphatase
NRK99_RS01980	COG2959	enzyme of heme biosynthesis
NRK99_RS01990	COG0181	hydroxymethylbilane synthase activity
NRK99_RS01995	COG3072	Adenylate cyclase
NRK99_RS02000	COG0400	carboxylic ester hydrolase activity
NRK99_RS02005	COG1965	Belongs to the frataxin family
NRK99_RS02015	COG0019	diaminopimelate decarboxylase activity
NRK99_RS02020	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NRK99_RS02035	COG1011	Hydrolase
NRK99_RS02055	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NRK99_RS02060	COG0561	phosphatase activity
NRK99_RS02075	COG0842	Transport permease protein
NRK99_RS02075	COG1129	ABC transporter
NRK99_RS02085	COG1058	Belongs to the CinA family
NRK99_RS02085	COG1546	Belongs to the CinA family
NRK99_RS02090	COG1418	mRNA catabolic process
NRK99_RS02095	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NRK99_RS02105	COG1522	sequence-specific DNA binding
NRK99_RS02110	COG1368	sulfuric ester hydrolase activity
NRK99_RS02130	COG1285	pathogenesis
NRK99_RS02150	COG4221	oxidoreductase activity
NRK99_RS02165	COG1979	alcohol dehydrogenase
NRK99_RS02175	COG2873	o-acetylhomoserine
NRK99_RS02200	COG5380	lipid catabolic process
NRK99_RS02205	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NRK99_RS02215	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NRK99_RS02220	COG2949	membrane
NRK99_RS02225	COG3291	Pkd domain containing protein
NRK99_RS02235	COG3539	Fimbrial protein
NRK99_RS02245	COG3188	usher protein
NRK99_RS02250	COG3121	Chaperone
NRK99_RS02255	COG3539	Fimbrial protein
NRK99_RS02270	COG0318	PFAM AMP-dependent synthetase and ligase
NRK99_RS02275	COG1441	menaquinone biosynthetic process
NRK99_RS02280	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NRK99_RS02285	COG0596	Alpha beta hydrolase
NRK99_RS02290	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NRK99_RS02295	COG1169	isochorismate synthase
NRK99_RS02300	COG1575	Belongs to the MenA family. Type 1 subfamily
NRK99_RS02330	COG0513	Belongs to the DEAD box helicase family
NRK99_RS02335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRK99_RS02340	COG1988	membrane-bound metal-dependent
NRK99_RS02355	COG1671	Belongs to the UPF0178 family
NRK99_RS02380	COG3263	regulation of cellular component size
NRK99_RS02385	COG3722	fumarate hydratase activity
NRK99_RS02390	COG0246	Mannitol dehydrogenase
NRK99_RS02395	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRK99_RS02395	COG2213	PTS system mannitol-specific
NRK99_RS02405	COG1309	transcriptional regulator
NRK99_RS02410	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
NRK99_RS02420	COG3916	Acyl-homoserine-lactone synthase
NRK99_RS02425	COG2771	luxR family
NRK99_RS02440	COG3133	Outer membrane lipoprotein
NRK99_RS02445	COG0456	acetyltransferase
NRK99_RS02465	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NRK99_RS02470	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NRK99_RS02480	COG3031	protein transport across the cell outer membrane
NRK99_RS02490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NRK99_RS02495	COG1459	type II secretion system
NRK99_RS02500	COG2165	general secretion pathway protein
NRK99_RS02510	COG2165	general secretion pathway protein
NRK99_RS02515	COG4795	General secretion pathway protein
NRK99_RS02520	COG3156	type II secretion system protein K
NRK99_RS02530	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
NRK99_RS02545	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NRK99_RS02555	COG1902	pentaerythritol trinitrate reductase activity
NRK99_RS02560	COG1011	Hydrolase
NRK99_RS02565	COG0494	nUDIX hydrolase
NRK99_RS02570	COG1218	3'(2'),5'-bisphosphate nucleotidase
NRK99_RS02575	COG0814	amino acid
NRK99_RS02580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRK99_RS02585	COG3708	Transcriptional regulator
NRK99_RS02585	COG2207	Transcriptional regulator
NRK99_RS02595	COG0626	cystathionine gamma-synthase activity
NRK99_RS02600	COG0527	aspartate kinase activity
NRK99_RS02600	COG0460	homoserine dehydrogenase
NRK99_RS02605	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NRK99_RS02615	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NRK99_RS02620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NRK99_RS02630	COG0137	argininosuccinate synthase activity
NRK99_RS02635	COG0165	Argininosuccinate lyase
NRK99_RS02660	COG0110	maltose O-acetyltransferase activity
NRK99_RS02665	COG3174	membrane
NRK99_RS02670	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NRK99_RS02680	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NRK99_RS02685	COG4208	sulfate ABC transporter
NRK99_RS02690	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NRK99_RS02695	COG0583	DNA-binding transcription factor activity
NRK99_RS02700	COG3397	chitin binding
NRK99_RS02735	COG4946	Tricorn protease homolog
NRK99_RS02735	COG0793	Belongs to the peptidase S41A family
NRK99_RS02755	COG1328	CTP reductase activity
NRK99_RS02760	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NRK99_RS02775	COG1448	Aminotransferase
NRK99_RS02815	COG0513	Belongs to the DEAD box helicase family
NRK99_RS02845	COG3112	Uncharacterised protein family (UPF0231)
NRK99_RS02850	COG3835	regulator
NRK99_RS02855	COG2610	gluconate transmembrane transporter activity
NRK99_RS02860	COG1929	Belongs to the glycerate kinase type-1 family
NRK99_RS02875	COG0583	DNA-binding transcription factor activity
NRK99_RS02880	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRK99_RS02895	COG0347	Belongs to the P(II) protein family
NRK99_RS02900	COG1840	ABC-type Fe3 transport system, periplasmic component
NRK99_RS02910	COG3842	ATPase activity
NRK99_RS02915	COG2837	iron assimilation
NRK99_RS02920	COG1438	arginine binding
NRK99_RS02925	COG1126	abc transporter atp-binding protein
NRK99_RS02930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRK99_RS02935	COG4215	(ABC) transporter
NRK99_RS02940	COG4160	amino acid transport
NRK99_RS02945	COG0039	L-malate dehydrogenase activity
NRK99_RS02950	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
NRK99_RS02955	COG1017	nitric oxide dioxygenase activity
NRK99_RS02955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NRK99_RS02960	COG1959	2 iron, 2 sulfur cluster binding
NRK99_RS02965	COG4536	flavin adenine dinucleotide binding
NRK99_RS02970	COG4137	Cytochrome C assembly protein
NRK99_RS02975	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NRK99_RS02980	COG0228	four-way junction DNA binding
NRK99_RS02985	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NRK99_RS02990	COG0336	Belongs to the RNA methyltransferase TrmD family
NRK99_RS02995	COG0335	large ribosomal subunit rRNA binding
NRK99_RS03005	COG3066	DNA modification
NRK99_RS03010	COG1051	belongs to the nudix hydrolase family
NRK99_RS03020	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NRK99_RS03025	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NRK99_RS03030	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NRK99_RS03180	COG4695	Portal protein
NRK99_RS03340	COG4974	Belongs to the 'phage' integrase family
NRK99_RS03345	COG0583	DNA-binding transcription factor activity
NRK99_RS03350	COG0640	Transcriptional regulator
NRK99_RS03355	COG0268	Binds directly to 16S ribosomal RNA
NRK99_RS03360	COG0728	peptidoglycan biosynthetic process
NRK99_RS03365	COG0196	riboflavin kinase activity
NRK99_RS03370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NRK99_RS03375	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NRK99_RS03380	COG1047	Peptidyl-prolyl cis-trans
NRK99_RS03385	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NRK99_RS03390	COG4970	Tfp pilus assembly protein FimT
NRK99_RS03445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NRK99_RS03445	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NRK99_RS03460	COG1854	S-ribosylhomocysteine lyase activity
NRK99_RS03465	COG3706	GGDEF domain
NRK99_RS03470	COG0557	exoribonuclease II activity
NRK99_RS03475	COG2801	Transposase and inactivated derivatives
NRK99_RS03490	COG2801	Transposase and inactivated derivatives
NRK99_RS03500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NRK99_RS03515	COG2153	protein acetylation
NRK99_RS03520	COG0697	spore germination
NRK99_RS03540	COG2814	Major facilitator Superfamily
NRK99_RS03545	COG1028	Short-chain dehydrogenase reductase Sdr
NRK99_RS03550	COG0583	DNA-binding transcription factor activity
NRK99_RS03560	COG1914	H( )-stimulated, divalent metal cation uptake system
NRK99_RS03565	COG0360	Binds together with S18 to 16S ribosomal RNA
NRK99_RS03570	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NRK99_RS03575	COG0359	binds to the 23S rRNA
NRK99_RS03580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NRK99_RS03610	COG1238	metal cluster binding
NRK99_RS03615	COG0612	Peptidase, M16
NRK99_RS03620	COG2918	glutathione biosynthetic process
NRK99_RS03625	COG1022	Amp-dependent synthetase and ligase
NRK99_RS03635	COG0456	acetyltransferase
NRK99_RS03645	COG0714	Associated with various cellular activities
NRK99_RS03650	COG2425	protein containing a von Willebrand factor type A (vWA) domain
NRK99_RS03665	COG5001	Diguanylate cyclase
NRK99_RS03690	COG1902	pentaerythritol trinitrate reductase activity
NRK99_RS03700	COG2852	Protein conserved in bacteria
NRK99_RS03710	COG2957	Belongs to the agmatine deiminase family
NRK99_RS03715	COG0154	amidase activity
NRK99_RS03735	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NRK99_RS03740	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NRK99_RS03750	COG0513	Belongs to the DEAD box helicase family
NRK99_RS03770	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
NRK99_RS03795	COG2070	2-Nitropropane dioxygenase
NRK99_RS03830	COG2205	protein histidine kinase activity
NRK99_RS03835	COG0745	RESPONSE REGULATOR receiver
NRK99_RS03840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRK99_RS03845	COG0577	efflux transmembrane transporter activity
NRK99_RS03845	COG1136	(ABC) transporter
NRK99_RS03850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRK99_RS03855	COG1126	abc transporter atp-binding protein
NRK99_RS03860	COG0765	amino acid transport
NRK99_RS03870	COG0765	amino acid transport
NRK99_RS03875	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NRK99_RS03880	COG1505	serine-type exopeptidase activity
NRK99_RS03885	COG2982	Protein involved in outer membrane biogenesis
NRK99_RS03895	COG1028	Short-chain dehydrogenase reductase Sdr
NRK99_RS03900	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NRK99_RS03915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NRK99_RS03920	COG4991	sh3 domain protein
NRK99_RS03930	COG2816	NAD+ diphosphatase activity
NRK99_RS03935	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NRK99_RS03940	COG1940	carbohydrate kinase activity
NRK99_RS03945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NRK99_RS03950	COG0126	phosphoglycerate kinase activity
NRK99_RS03960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRK99_RS04005	COG0354	folic acid binding
NRK99_RS04010	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NRK99_RS04020	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NRK99_RS04025	COG1595	DNA-templated transcription, initiation
NRK99_RS04030	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
NRK99_RS04045	COG0481	GTPase activity
NRK99_RS04050	COG0681	Belongs to the peptidase S26 family
NRK99_RS04055	COG0571	ribonuclease III activity
NRK99_RS04065	COG1381	Involved in DNA repair and RecF pathway recombination
NRK99_RS04070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NRK99_RS04085	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NRK99_RS04090	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRK99_RS04095	COG3716	PTS system mannose fructose sorbose family IID component
NRK99_RS04105	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRK99_RS04110	COG2222	sugar isomerase
NRK99_RS04120	COG1349	DNA-binding transcription factor activity
NRK99_RS04125	COG3023	N-Acetylmuramoyl-L-alanine amidase
NRK99_RS04130	COG4807	Protein conserved in bacteria
NRK99_RS04140	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NRK99_RS04145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NRK99_RS04150	COG3956	TIGRFAM MazG family protein
NRK99_RS04155	COG0504	CTP synthase activity
NRK99_RS04160	COG0148	phosphopyruvate hydratase activity
NRK99_RS04165	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NRK99_RS04170	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NRK99_RS04180	COG0585	pseudouridine synthase activity
NRK99_RS04185	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NRK99_RS04190	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NRK99_RS04195	COG1238	metal cluster binding
NRK99_RS04210	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NRK99_RS04215	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NRK99_RS04220	COG1610	YqeY-like protein
NRK99_RS04225	COG0358	DNA primase activity
NRK99_RS04230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NRK99_RS04255	COG0138	bifunctional purine biosynthesis protein purh
NRK99_RS04270	COG3036	rescue of stalled ribosome
NRK99_RS04275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NRK99_RS04280	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NRK99_RS04290	COG0673	inositol 2-dehydrogenase activity
NRK99_RS04300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRK99_RS04305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRK99_RS04310	COG3227	Zinc metalloprotease (Elastase)
NRK99_RS04320	COG0477	Major facilitator Superfamily
NRK99_RS04330	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NRK99_RS04335	COG1027	Aspartate ammonia-lyase
NRK99_RS04340	COG3030	protein affecting phage T7 exclusion by the F plasmid
NRK99_RS04345	COG0534	Mate efflux family protein
NRK99_RS04350	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NRK99_RS04355	COG0459	protein refolding
NRK99_RS04365	COG5001	Diguanylate cyclase
NRK99_RS04365	COG3300	MHYT domain
NRK99_RS04375	COG0564	pseudouridine synthase activity
NRK99_RS04380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NRK99_RS04410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NRK99_RS04420	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NRK99_RS04430	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
NRK99_RS04440	COG4143	(ABC) transporter
NRK99_RS04455	COG0066	3-isopropylmalate dehydratase activity
NRK99_RS04460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NRK99_RS04465	COG0473	3-isopropylmalate dehydrogenase activity
NRK99_RS04470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NRK99_RS04480	COG0671	phosphoesterase, PA-phosphatase related
NRK99_RS04495	COG0028	Belongs to the TPP enzyme family
NRK99_RS04500	COG0440	acetolactate synthase activity
NRK99_RS04505	COG0857	belongs to the CobB CobQ family
NRK99_RS04505	COG0280	phosphate acetyltransferase
NRK99_RS04510	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NRK99_RS04520	COG3013	Belongs to the UPF0304 family
NRK99_RS04525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NRK99_RS04530	COG2716	regulation of RNA biosynthetic process
NRK99_RS04540	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
NRK99_RS04545	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NRK99_RS04560	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
NRK99_RS04580	COG0784	Response regulator, receiver
NRK99_RS04580	COG2198	Histidine kinase
NRK99_RS04580	COG5002	protein histidine kinase activity
NRK99_RS04605	COG0840	transmembrane signaling receptor activity
NRK99_RS04615	COG1464	Belongs to the NlpA lipoprotein family
NRK99_RS04620	COG2011	ABC-type metal ion transport system permease component
NRK99_RS04625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NRK99_RS04645	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NRK99_RS04645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NRK99_RS04650	COG0802	atpase or kinase
NRK99_RS04660	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NRK99_RS04665	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NRK99_RS04670	COG1923	regulation of RNA biosynthetic process
NRK99_RS04675	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NRK99_RS04680	COG0330	HflC and HflK could
NRK99_RS04685	COG0330	HflC and HflK could
NRK99_RS04690	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
NRK99_RS04695	COG0142	geranyltranstransferase activity
NRK99_RS04700	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NRK99_RS04705	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NRK99_RS04710	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NRK99_RS04715	COG3314	Sporulation integral membrane protein YlbJ
NRK99_RS04720	COG0318	PFAM AMP-dependent synthetase and ligase
NRK99_RS04735	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NRK99_RS04740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NRK99_RS04750	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NRK99_RS04755	COG2967	ApaG domain
NRK99_RS04760	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NRK99_RS04765	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NRK99_RS04775	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NRK99_RS04780	COG3178	'Phosphotransferase
NRK99_RS04785	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NRK99_RS04790	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NRK99_RS04795	COG2252	PERMEase
NRK99_RS04805	COG0488	(ABC) transporter
NRK99_RS04820	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NRK99_RS04825	COG0741	lytic transglycosylase activity
NRK99_RS04850	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NRK99_RS04855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRK99_RS04865	COG3721	Heme iron utilization protein
NRK99_RS04870	COG0748	coenzyme F420 binding
NRK99_RS04890	COG4771	TonB-dependent receptor
NRK99_RS04895	COG2814	Major facilitator Superfamily
NRK99_RS04905	COG3655	Transcriptional regulator
NRK99_RS04915	COG2205	protein histidine kinase activity
NRK99_RS04915	COG2202	Pas domain
NRK99_RS04930	COG3397	chitin binding
NRK99_RS04945	COG1765	OsmC-like protein
NRK99_RS04960	COG3954	Phosphoribulokinase
NRK99_RS04965	COG2076	Multidrug Resistance protein
NRK99_RS04970	COG2076	Multidrug Resistance protein
NRK99_RS04975	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NRK99_RS04980	COG0726	polysaccharide deacetylase
NRK99_RS04985	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NRK99_RS04985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRK99_RS04990	COG0463	Glycosyl transferase, family 2
NRK99_RS04995	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NRK99_RS05005	COG3089	Belongs to the UPF0270 family
NRK99_RS05010	COG0429	hydrolase of the alpha beta-hydrolase fold
NRK99_RS05015	COG0784	Response regulator, receiver
NRK99_RS05015	COG0835	chemotaxis
NRK99_RS05025	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
NRK99_RS05030	COG1047	Peptidyl-prolyl cis-trans
NRK99_RS05035	COG2900	Belongs to the SlyX family
NRK99_RS05045	COG0545	Peptidyl-prolyl cis-trans isomerase
NRK99_RS05050	COG2204	response regulator
NRK99_RS05070	COG0737	Belongs to the 5'-nucleotidase family
NRK99_RS05075	COG2200	EAL domain
NRK99_RS05090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NRK99_RS05095	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRK99_RS05100	COG0826	peptidase U32
NRK99_RS05105	COG2199	diguanylate cyclase activity
NRK99_RS05105	COG2200	EAL domain
NRK99_RS05105	COG2203	Gaf domain
NRK99_RS05130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NRK99_RS05135	COG2201	protein-glutamate methylesterase activity
NRK99_RS05140	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
NRK99_RS05150	COG0840	transmembrane signaling receptor activity
NRK99_RS05155	COG0835	chemotaxis
NRK99_RS05165	COG2198	Histidine kinase
NRK99_RS05165	COG0643	Histidine kinase
NRK99_RS05175	COG0745	RESPONSE REGULATOR receiver
NRK99_RS05185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NRK99_RS05195	COG1280	lysine exporter protein (LysE YggA)
NRK99_RS05200	COG0826	peptidase U32
NRK99_RS05230	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NRK99_RS05255	COG0300	oxidoreductase activity
NRK99_RS05265	COG0840	transmembrane signaling receptor activity
NRK99_RS05275	COG2610	gluconate transmembrane transporter activity
NRK99_RS05280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRK99_RS05285	COG3622	Belongs to the hyi family
NRK99_RS05290	COG0235	Class ii aldolase
NRK99_RS05300	COG2084	Dehydrogenase
NRK99_RS05305	COG1349	DNA-binding transcription factor activity
NRK99_RS05330	COG0077	Prephenate dehydratase
NRK99_RS05330	COG1605	Chorismate mutase
NRK99_RS05360	COG3272	Protein of unknown function (DUF1722)
NRK99_RS05365	COG0789	Transcriptional regulator
NRK99_RS05370	COG0415	Belongs to the DNA photolyase family
NRK99_RS05380	COG4221	oxidoreductase activity
NRK99_RS05395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NRK99_RS05420	COG0783	Belongs to the Dps family
NRK99_RS05425	COG1151	hydroxylamine reductase activity
NRK99_RS05435	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NRK99_RS05440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NRK99_RS05440	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NRK99_RS05450	COG2831	hemolysin activation secretion protein
NRK99_RS05475	COG2771	luxR family
NRK99_RS05495	COG4104	PAAR repeat-containing protein
NRK99_RS05535	COG0693	protein deglycase activity
NRK99_RS05540	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NRK99_RS05545	COG1666	GTP binding
NRK99_RS05555	COG2211	Major facilitator Superfamily
NRK99_RS05565	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NRK99_RS05575	COG2813	Specifically methylates the guanine in position
NRK99_RS05580	COG0271	Belongs to the BolA IbaG family
NRK99_RS05585	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NRK99_RS05590	COG1805	sodium ion transport
NRK99_RS05595	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NRK99_RS05600	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NRK99_RS05605	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NRK99_RS05610	COG2871	sodium ion transport
NRK99_RS05615	COG1477	protein flavinylation
NRK99_RS05630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NRK99_RS05635	COG0840	transmembrane signaling receptor activity
NRK99_RS05640	COG0583	DNA-binding transcription factor activity
NRK99_RS05650	COG2363	Small membrane protein
NRK99_RS05655	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
NRK99_RS05665	COG0473	3-isopropylmalate dehydrogenase activity
NRK99_RS05670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NRK99_RS05675	COG1611	Belongs to the LOG family
NRK99_RS05690	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NRK99_RS05690	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NRK99_RS05700	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
NRK99_RS05725	COG3098	single-species biofilm formation
NRK99_RS05730	COG0564	pseudouridine synthase activity
NRK99_RS05760	COG2171	N-acyltransferase activity
NRK99_RS05765	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NRK99_RS05770	COG0024	Methionine aminopeptidase
NRK99_RS05775	COG0052	Belongs to the universal ribosomal protein uS2 family
NRK99_RS05780	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NRK99_RS05785	COG0528	UMP kinase activity
NRK99_RS05790	COG0233	cytoplasmic translational termination
NRK99_RS05795	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NRK99_RS05800	COG0575	Belongs to the CDS family
NRK99_RS05805	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NRK99_RS05810	COG0750	zinc metalloprotease
NRK99_RS05825	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NRK99_RS05830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NRK99_RS05835	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NRK99_RS05840	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NRK99_RS05845	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NRK99_RS05855	COG0825	malonyl-CoA metabolic process
NRK99_RS05860	COG3710	Transcriptional regulator
NRK99_RS05865	COG0531	amino acid
NRK99_RS05870	COG1982	Orn Lys Arg decarboxylase major
NRK99_RS05875	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
NRK99_RS05890	COG0814	amino acid
NRK99_RS05895	COG0531	amino acid
NRK99_RS05905	COG0488	(ABC) transporter
NRK99_RS05910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NRK99_RS05920	COG0180	Tryptophanyl-tRNA synthetase
NRK99_RS05935	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NRK99_RS05945	COG1012	belongs to the aldehyde dehydrogenase family
NRK99_RS05955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRK99_RS05965	COG0674	pyruvate-flavodoxin oxidoreductase activity
NRK99_RS05965	COG1013	pyruvate-flavodoxin oxidoreductase activity
NRK99_RS05965	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NRK99_RS05965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRK99_RS05995	COG0488	(ABC) transporter
NRK99_RS06005	COG0366	Alpha amylase catalytic
NRK99_RS06025	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
NRK99_RS06035	COG0471	metal ion transport
NRK99_RS06035	COG0490	domain, Protein
NRK99_RS06075	COG0012	GTP binding
NRK99_RS06080	COG0193	aminoacyl-tRNA hydrolase activity
NRK99_RS06085	COG0737	Belongs to the 5'-nucleotidase family
NRK99_RS06090	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NRK99_RS06100	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NRK99_RS06105	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NRK99_RS06110	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NRK99_RS06115	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NRK99_RS06120	COG2890	protein-(glutamine-N5) methyltransferase activity
NRK99_RS06130	COG2912	Transglutaminase-like superfamily
NRK99_RS06135	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NRK99_RS06140	COG1301	dicarboxylic acid transport
NRK99_RS06150	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NRK99_RS06165	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NRK99_RS06170	COG1115	amino acid carrier protein
NRK99_RS06185	COG0714	Associated with various cellular activities
NRK99_RS06195	COG3104	oligopeptide transport
NRK99_RS06200	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NRK99_RS06205	COG1678	Uncharacterized ACR, COG1678
NRK99_RS06215	COG0189	ligase activity
NRK99_RS06220	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NRK99_RS06230	COG3091	SprT-like family
NRK99_RS06240	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NRK99_RS06255	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NRK99_RS06260	COG0739	heme binding
NRK99_RS06265	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NRK99_RS06270	COG3408	Glycogen debranching enzyme
NRK99_RS06270	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
NRK99_RS06280	COG1881	PFAM PEBP family protein
NRK99_RS06285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NRK99_RS06290	COG0583	DNA-binding transcription factor activity
NRK99_RS06300	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NRK99_RS06310	COG0583	DNA-binding transcription factor activity
NRK99_RS06315	COG1028	Short-chain dehydrogenase reductase Sdr
NRK99_RS06320	COG0616	signal peptide processing
NRK99_RS06325	COG3724	N-succinylarginine dihydrolase activity
NRK99_RS06345	COG0840	transmembrane signaling receptor activity
NRK99_RS06355	COG2971	BadF BadG BcrA BcrD
NRK99_RS06365	COG4608	Belongs to the ABC transporter superfamily
NRK99_RS06370	COG0444	Belongs to the ABC transporter superfamily
NRK99_RS06375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRK99_RS06380	COG0601	transmembrane transport
NRK99_RS06385	COG4166	transmembrane transport
NRK99_RS06390	COG0784	Response regulator, receiver
NRK99_RS06390	COG2205	protein histidine kinase activity
NRK99_RS06430	COG3220	belongs to the UPF0276 family
NRK99_RS06460	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NRK99_RS06465	COG1289	transmembrane transporter activity
NRK99_RS06470	COG0303	'Molybdopterin
NRK99_RS06475	COG0746	molybdenum cofactor guanylyltransferase activity
NRK99_RS06485	COG4662	Binding-protein-dependent transport system inner membrane component
NRK99_RS06500	COG3852	Histidine kinase
NRK99_RS06510	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NRK99_RS06550	COG3383	formate dehydrogenase (NAD+) activity
NRK99_RS06550	COG3383	formate dehydrogenase (NAD+) activity
NRK99_RS06555	COG0437	4 iron, 4 sulfur cluster binding
NRK99_RS06565	COG0281	malic enzyme
NRK99_RS06585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRK99_RS06600	COG2706	6-phosphogluconolactonase activity
NRK99_RS06610	COG1196	nuclear chromosome segregation
NRK99_RS06610	COG3264	Mechanosensitive ion channel
NRK99_RS06615	COG0469	pyruvate kinase activity
NRK99_RS06630	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NRK99_RS06630	COG4651	solute:proton antiporter activity
NRK99_RS06640	COG2974	May be involved in recombination
NRK99_RS06650	COG0420	3'-5' exonuclease activity
NRK99_RS06665	COG3038	cytochrome b561
NRK99_RS06675	COG2190	(PTS) system
NRK99_RS06680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NRK99_RS06685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRK99_RS06690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NRK99_RS06695	COG0542	response to heat
NRK99_RS06710	COG2770	Histidine kinase
NRK99_RS06710	COG3437	response regulator, receiver
NRK99_RS06715	COG1720	tRNA m6t6A37 methyltransferase activity
NRK99_RS06735	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NRK99_RS06740	COG4988	ABC transporter
NRK99_RS06755	COG0745	RESPONSE REGULATOR receiver
NRK99_RS06765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NRK99_RS06780	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
NRK99_RS06785	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
NRK99_RS06795	COG0083	homoserine kinase activity
NRK99_RS06800	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NRK99_RS06805	COG4319	ketosteroid isomerase
NRK99_RS06820	COG0488	(ABC) transporter
NRK99_RS06850	COG0813	purine-nucleoside phosphorylase activity
NRK99_RS06870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRK99_RS06870	COG2205	protein histidine kinase activity
NRK99_RS06875	COG5001	Diguanylate cyclase
NRK99_RS06875	COG2203	Gaf domain
NRK99_RS06875	COG3706	GGDEF domain
NRK99_RS06875	COG4251	negative regulation of phosphorylation
NRK99_RS06880	COG0784	Response regulator, receiver
NRK99_RS06880	COG2205	protein histidine kinase activity
NRK99_RS06880	COG5002	protein histidine kinase activity
NRK99_RS06885	COG3384	dioxygenase
NRK99_RS06895	COG1283	sodium-dependent phosphate transmembrane transporter activity
NRK99_RS06905	COG0531	amino acid
NRK99_RS06915	COG0531	amino acid
NRK99_RS06935	COG1396	sequence-specific DNA binding
NRK99_RS06935	COG1917	Cupin 2, conserved barrel domain protein
NRK99_RS06940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRK99_RS06960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NRK99_RS06965	COG2375	cellular response to nickel ion
NRK99_RS06975	COG0577	efflux transmembrane transporter activity
NRK99_RS06975	COG1136	(ABC) transporter
NRK99_RS06980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRK99_RS06990	COG1227	inorganic diphosphatase activity
NRK99_RS06995	COG0497	DNA recombination
NRK99_RS07000	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NRK99_RS07005	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NRK99_RS07010	COG0443	Heat shock 70 kDa protein
NRK99_RS07015	COG0484	heat shock protein binding
NRK99_RS07045	COG1285	pathogenesis
NRK99_RS07060	COG0640	Transcriptional regulator
NRK99_RS07090	COG0095	Lipoate-protein ligase
NRK99_RS07105	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRK99_RS07110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRK99_RS07135	COG0708	Exodeoxyribonuclease III
NRK99_RS07150	COG0071	Belongs to the small heat shock protein (HSP20) family
NRK99_RS07200	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NRK99_RS07205	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NRK99_RS07210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NRK99_RS07215	COG1845	cytochrome c oxidase, subunit III
NRK99_RS07220	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NRK99_RS07225	COG0109	protoheme IX farnesyltransferase activity
NRK99_RS07230	COG2814	Major facilitator Superfamily
NRK99_RS07240	COG2175	clavaminate synthase activity
NRK99_RS07245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NRK99_RS07250	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NRK99_RS07255	COG4521	taurine ABC transporter
NRK99_RS07265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRK99_RS07285	COG3550	peptidyl-serine autophosphorylation
NRK99_RS07290	COG1396	sequence-specific DNA binding
NRK99_RS07295	COG1988	membrane-bound metal-dependent
NRK99_RS07310	COG0159	tryptophan synthase activity
NRK99_RS07315	COG0133	tryptophan synthase activity
NRK99_RS07320	COG0134	indole-3-glycerol-phosphate synthase activity
NRK99_RS07320	COG0135	phosphoribosylanthranilate isomerase activity
NRK99_RS07325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NRK99_RS07330	COG0512	Glutamine amidotransferase of anthranilate synthase
NRK99_RS07330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NRK99_RS07335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NRK99_RS07345	COG0009	L-threonylcarbamoyladenylate synthase
NRK99_RS07355	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NRK99_RS07365	COG1946	Acyl-CoA thioesterase
NRK99_RS07385	COG1309	transcriptional regulator
NRK99_RS07390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRK99_RS07395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRK99_RS07410	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NRK99_RS07425	COG0438	transferase activity, transferring glycosyl groups
NRK99_RS07435	COG0367	asparagine synthase
NRK99_RS07440	COG0438	transferase activity, transferring glycosyl groups
NRK99_RS07450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NRK99_RS07465	COG1091	dTDP-4-dehydrorhamnose reductase activity
NRK99_RS07470	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NRK99_RS07490	COG3132	Protein of unknown function, DUF480
NRK99_RS07530	COG1278	Cold shock
NRK99_RS07555	COG4166	transmembrane transport
NRK99_RS07560	COG0697	spore germination
NRK99_RS07565	COG1349	DNA-binding transcription factor activity
NRK99_RS07570	COG1882	Formate acetyltransferase
NRK99_RS07575	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NRK99_RS07580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NRK99_RS07605	COG4166	transmembrane transport
NRK99_RS07610	COG0622	Phosphoesterase
NRK99_RS07625	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
NRK99_RS07630	COG0784	Response regulator, receiver
NRK99_RS07630	COG0835	chemotaxis
NRK99_RS07635	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NRK99_RS07640	COG1815	bacterial-type flagellum-dependent cell motility
NRK99_RS07660	COG4787	bacterial-type flagellum-dependent cell motility
NRK99_RS07670	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NRK99_RS07675	COG1706	bacterial-type flagellum-dependent cell motility
NRK99_RS07680	COG1705	Flagellar rod assembly protein muramidase FlgJ
NRK99_RS07680	COG3951	Flagellar rod assembly protein muramidase FlgJ
NRK99_RS07695	COG2239	Acts as a magnesium transporter
NRK99_RS07705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NRK99_RS07710	COG2716	regulation of RNA biosynthetic process
NRK99_RS07735	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NRK99_RS07740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NRK99_RS07745	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NRK99_RS07750	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NRK99_RS07770	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NRK99_RS07785	COG0590	tRNA wobble adenosine to inosine editing
NRK99_RS07790	COG0573	inorganic phosphate transmembrane transporter activity
NRK99_RS07795	COG0581	inorganic phosphate transmembrane transporter activity
NRK99_RS07800	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NRK99_RS07805	COG0704	Plays a role in the regulation of phosphate uptake
NRK99_RS07810	COG1253	flavin adenine dinucleotide binding
NRK99_RS07825	COG0531	amino acid
NRK99_RS07845	COG1126	abc transporter atp-binding protein
NRK99_RS07850	COG0765	amino acid transport
NRK99_RS07855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRK99_RS07860	COG2271	Major facilitator Superfamily
NRK99_RS07875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NRK99_RS07900	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NRK99_RS07905	COG0477	Major facilitator Superfamily
NRK99_RS07915	COG0123	including yeast histone deacetylase and acetoin utilization protein
NRK99_RS07925	COG1199	ATP-dependent helicase activity
NRK99_RS07940	COG1448	Aminotransferase
NRK99_RS07945	COG0433	COG0433 Predicted ATPase
NRK99_RS07960	COG0658	competence protein
NRK99_RS07960	COG2333	competence protein COMEC
NRK99_RS07970	COG1663	tetraacyldisaccharide 4'-kinase activity
NRK99_RS07975	COG2835	tetraacyldisaccharide 4'-kinase activity
NRK99_RS07980	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NRK99_RS07985	COG2197	response regulator
NRK99_RS07990	COG0322	excinuclease ABC activity
NRK99_RS08040	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
NRK99_RS08045	COG0437	4 iron, 4 sulfur cluster binding
NRK99_RS08050	COG3301	Polysulphide reductase, NrfD
NRK99_RS08055	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NRK99_RS08065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NRK99_RS08085	COG2203	Gaf domain
NRK99_RS08085	COG2199	diguanylate cyclase activity
NRK99_RS08115	COG2119	membrane
NRK99_RS08120	COG0023	Translation Initiation Factor
NRK99_RS08160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRK99_RS08160	COG2205	protein histidine kinase activity
NRK99_RS08170	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
NRK99_RS08175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NRK99_RS08180	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NRK99_RS08185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NRK99_RS08190	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NRK99_RS08195	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NRK99_RS08205	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NRK99_RS08210	COG0505	Belongs to the CarA family
NRK99_RS08215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NRK99_RS08220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NRK99_RS08235	COG2814	Major facilitator Superfamily
NRK99_RS08280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRK99_RS08285	COG0513	Belongs to the DEAD box helicase family
NRK99_RS08295	COG4104	PAAR repeat-containing protein
NRK99_RS08310	COG0789	Transcriptional regulator
NRK99_RS08325	COG0493	'glutamate synthase
NRK99_RS08330	COG0067	glutamate synthase
NRK99_RS08330	COG0070	glutamate synthase
NRK99_RS08330	COG0069	glutamate synthase activity
NRK99_RS08335	COG1242	4 iron, 4 sulfur cluster binding
NRK99_RS08390	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NRK99_RS08395	COG0574	Belongs to the PEP-utilizing enzyme family
NRK99_RS08395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NRK99_RS08435	COG1464	Belongs to the NlpA lipoprotein family
NRK99_RS08440	COG0671	phosphoesterase, PA-phosphatase related
NRK99_RS08445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NRK99_RS08450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NRK99_RS08460	COG0101	tRNA pseudouridine synthase activity
NRK99_RS08465	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NRK99_RS08470	COG0285	dihydrofolate synthase activity
NRK99_RS08475	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
NRK99_RS08480	COG2920	part of a sulfur-relay system
NRK99_RS08485	COG1289	transmembrane transporter activity
NRK99_RS08490	COG0670	Belongs to the BI1 family
NRK99_RS08510	COG1196	nuclear chromosome segregation
NRK99_RS08515	COG0210	DNA helicase
NRK99_RS08535	COG0210	DNA helicase
NRK99_RS08575	COG2003	Belongs to the UPF0758 family
NRK99_RS08605	COG3311	Transcriptional regulator
NRK99_RS08625	COG3501	Rhs element vgr protein
NRK99_RS08635	COG3209	COG3209 Rhs family protein
NRK99_RS08635	COG4104	PAAR repeat-containing protein
NRK99_RS08655	COG0582	viral genome integration into host DNA
NRK99_RS08670	COG4792	protein secretion
NRK99_RS08675	COG4791	protein targeting
NRK99_RS08680	COG4794	Type iii secretion
NRK99_RS08685	COG4790	Type iii secretion
NRK99_RS08755	COG0457	Tetratricopeptide repeat
NRK99_RS08845	COG1317	bacterial-type flagellum organization
NRK99_RS08860	COG2194	sulfuric ester hydrolase activity
NRK99_RS08865	COG0392	lysyltransferase activity
NRK99_RS08865	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NRK99_RS08875	COG0840	transmembrane signaling receptor activity
NRK99_RS08880	COG5001	Diguanylate cyclase
NRK99_RS08885	COG0564	pseudouridine synthase activity
NRK99_RS08900	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NRK99_RS08910	COG0625	glutathione transferase activity
NRK99_RS08930	COG0367	asparagine synthase
NRK99_RS08940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NRK99_RS08940	COG4651	solute:proton antiporter activity
NRK99_RS08945	COG0647	UMP catabolic process
NRK99_RS08950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NRK99_RS08955	COG1902	pentaerythritol trinitrate reductase activity
NRK99_RS08960	COG1253	flavin adenine dinucleotide binding
NRK99_RS08970	COG0247	lactate metabolic process
NRK99_RS08970	COG0277	FAD linked oxidase domain protein
NRK99_RS08980	COG2050	protein possibly involved in aromatic compounds catabolism
NRK99_RS08990	COG2056	Na+-H+ antiporter family
NRK99_RS08995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NRK99_RS09010	COG0346	lactoylglutathione lyase activity
NRK99_RS09015	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NRK99_RS09020	COG4660	Part of a membrane complex involved in electron transport
NRK99_RS09025	COG4659	FMN binding
NRK99_RS09030	COG4658	electron transport chain
NRK99_RS09040	COG2878	Part of a membrane complex involved in electron transport
NRK99_RS09045	COG4657	Part of a membrane complex involved in electron transport
NRK99_RS09050	COG0697	spore germination
NRK99_RS09065	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NRK99_RS09070	COG1288	antiporter activity
NRK99_RS09075	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NRK99_RS09075	COG3264	Mechanosensitive ion channel
NRK99_RS09080	COG0436	Aminotransferase
NRK99_RS09090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NRK99_RS09095	COG2027	D-alanyl-D-alanine carboxypeptidase
NRK99_RS09100	COG1061	Type III restriction enzyme res subunit
NRK99_RS09105	COG1566	PFAM secretion protein HlyD family protein
NRK99_RS09115	COG1966	Carbon starvation protein
NRK99_RS09120	COG3279	Response regulator of the LytR AlgR family
NRK99_RS09125	COG3275	phosphorelay sensor kinase activity
NRK99_RS09130	COG2199	diguanylate cyclase activity
NRK99_RS09130	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NRK99_RS09135	COG1454	alcohol dehydrogenase
NRK99_RS09135	COG1012	belongs to the aldehyde dehydrogenase family
NRK99_RS09145	COG2095	MarC family integral membrane protein
NRK99_RS09155	COG0601	transmembrane transport
NRK99_RS09160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRK99_RS09165	COG0444	Belongs to the ABC transporter superfamily
NRK99_RS09175	COG0861	Integral membrane protein TerC family
NRK99_RS09180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NRK99_RS09190	COG1301	dicarboxylic acid transport
NRK99_RS09205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NRK99_RS09220	COG0537	adenosine 5'-monophosphoramidase activity
NRK99_RS09255	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRK99_RS09260	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRK99_RS09275	COG2354	Protein conserved in bacteria
NRK99_RS09290	COG2233	PERMEase
NRK99_RS09295	COG3150	esterase
NRK99_RS09300	COG1252	NADH dehydrogenase
NRK99_RS09320	COG0393	Putative heavy-metal-binding
NRK99_RS09330	COG1619	proteins homologs of microcin C7 resistance protein MccF
NRK99_RS09335	COG1368	sulfuric ester hydrolase activity
NRK99_RS09345	COG0527	aspartate kinase activity
NRK99_RS09350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NRK99_RS09350	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NRK99_RS09355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NRK99_RS09375	COG0596	Alpha beta hydrolase
NRK99_RS09380	COG0583	DNA-binding transcription factor activity
NRK99_RS09385	COG1620	l-lactate permease
NRK99_RS09390	COG0247	lactate metabolic process
NRK99_RS09395	COG1139	Iron-sulfur cluster binding protein
NRK99_RS09410	COG1196	nuclear chromosome segregation
NRK99_RS09425	COG0577	efflux transmembrane transporter activity
NRK99_RS09430	COG1136	(ABC) transporter
NRK99_RS09450	COG2814	Major facilitator Superfamily
NRK99_RS09470	COG0672	)-iron permease
NRK99_RS09510	COG0659	secondary active sulfate transmembrane transporter activity
NRK99_RS09535	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NRK99_RS09540	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
NRK99_RS09545	COG0437	4 iron, 4 sulfur cluster binding
NRK99_RS09550	COG5557	Pfam Polysulphide reductase, NrfD
NRK99_RS09555	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
NRK99_RS09560	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NRK99_RS09565	COG1773	rubredoxin
NRK99_RS09575	COG0601	transmembrane transport
NRK99_RS09580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRK99_RS09590	COG1124	(ABC) transporter
NRK99_RS09595	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NRK99_RS09605	COG0375	protein maturation
NRK99_RS09610	COG0309	Hydrogenase expression formation protein (HypE)
NRK99_RS09620	COG0298	carbon dioxide binding
NRK99_RS09625	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
NRK99_RS09635	COG1921	L-seryl-tRNASec selenium transferase activity
NRK99_RS09645	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NRK99_RS09655	COG3260	NADH ubiquinone oxidoreductase 20
NRK99_RS09660	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRK99_RS09665	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
NRK99_RS09665	COG3261	NADH dehydrogenase
NRK99_RS09670	COG0650	Formate hydrogenlyase subunit 4
NRK99_RS09675	COG0651	ATP synthesis coupled electron transport
NRK99_RS09680	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRK99_RS09685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NRK99_RS09695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRK99_RS09700	COG2223	nitrite transmembrane transporter activity
NRK99_RS09710	COG3158	transport of potassium into the cell
NRK99_RS09720	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRK99_RS09745	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NRK99_RS09750	COG0326	Molecular chaperone. Has ATPase activity
NRK99_RS09755	COG0563	adenylate kinase activity
NRK99_RS09760	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NRK99_RS09765	COG3788	relative of glutathione S-transferase, MAPEG superfamily
NRK99_RS09770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRK99_RS09785	COG3300	MHYT domain
NRK99_RS09785	COG5001	Diguanylate cyclase
NRK99_RS09790	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NRK99_RS09815	COG1021	2,3-dihydroxybenzoate-AMP ligase
NRK99_RS09820	COG1535	isochorismatase
NRK99_RS09820	COG3433	isochorismatase activity
NRK99_RS09825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRK99_RS09830	COG1028	Short-chain dehydrogenase reductase Sdr
NRK99_RS09840	COG0300	oxidoreductase activity
NRK99_RS09840	COG3321	synthase
NRK99_RS09840	COG1028	Short-chain dehydrogenase reductase Sdr
NRK99_RS09840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRK99_RS09840	COG0318	PFAM AMP-dependent synthetase and ligase
NRK99_RS09845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NRK99_RS09850	COG2977	Belongs to the P-Pant transferase superfamily
NRK99_RS09855	COG1120	ATPase activity
NRK99_RS09860	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRK99_RS09865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRK99_RS09870	COG4771	TonB-dependent receptor
NRK99_RS09910	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NRK99_RS09915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NRK99_RS09920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NRK99_RS09935	COG1570	exodeoxyribonuclease VII activity
NRK99_RS09940	COG0697	spore germination
NRK99_RS09960	COG3158	transport of potassium into the cell
NRK99_RS09965	COG0517	IMP dehydrogenase activity
NRK99_RS09965	COG0516	GMP reductase activity
NRK99_RS09970	COG0519	Catalyzes the synthesis of GMP from XMP
NRK99_RS09970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NRK99_RS10015	COG2062	phosphohistidine phosphatase, SixA
NRK99_RS10025	COG0697	spore germination
NRK99_RS10030	COG4166	transmembrane transport
NRK99_RS10035	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NRK99_RS10040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NRK99_RS10050	COG4591	ABC-type transport system involved in lipoprotein release permease component
NRK99_RS10055	COG1136	(ABC) transporter
NRK99_RS10060	COG4591	ABC-type transport system involved in lipoprotein release permease component
NRK99_RS10065	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
NRK99_RS10075	COG0544	peptidyl-prolyl cis-trans isomerase activity
NRK99_RS10080	COG0740	serine-type endopeptidase activity
NRK99_RS10085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NRK99_RS10090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NRK99_RS10095	COG0776	regulation of translation
NRK99_RS10100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NRK99_RS10105	COG0488	(ABC) transporter
NRK99_RS10110	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NRK99_RS10115	COG3162	membrane
NRK99_RS10130	COG1024	Enoyl-CoA hydratase
NRK99_RS10135	COG1115	amino acid carrier protein
NRK99_RS10150	COG1584	GPR1 FUN34 yaaH family protein
NRK99_RS10185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NRK99_RS10190	COG1960	acyl-CoA dehydrogenase activity
NRK99_RS10200	COG1960	acyl-CoA dehydrogenase activity
NRK99_RS10205	COG1024	Enoyl-CoA hydratase
NRK99_RS10210	COG1024	Enoyl-CoA hydratase
NRK99_RS10220	COG1028	Short-chain dehydrogenase reductase Sdr
NRK99_RS10230	COG0730	response to heat
NRK99_RS10245	COG1073	alpha beta
NRK99_RS10250	COG0823	Involved in the tonB-independent uptake of proteins
NRK99_RS10250	COG1506	peptidase
NRK99_RS10255	COG0702	epimerase
NRK99_RS10260	COG0583	DNA-binding transcription factor activity
NRK99_RS10265	COG0667	Aldo Keto reductase
NRK99_RS10315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NRK99_RS10320	COG1215	transferase activity, transferring glycosyl groups
NRK99_RS10325	COG0438	transferase activity, transferring glycosyl groups
NRK99_RS10345	COG2801	Transposase and inactivated derivatives
NRK99_RS10400	COG0438	transferase activity, transferring glycosyl groups
NRK99_RS10405	COG0583	DNA-binding transcription factor activity
NRK99_RS10410	COG2723	6-phospho-beta-galactosidase activity
NRK99_RS10415	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NRK99_RS10425	COG0583	DNA-binding transcription factor activity
NRK99_RS10430	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NRK99_RS10435	COG0673	inositol 2-dehydrogenase activity
NRK99_RS10440	COG0583	DNA-binding transcription factor activity
NRK99_RS10450	COG1560	Kdo2-lipid A biosynthetic process
NRK99_RS10455	COG1560	Kdo2-lipid A biosynthetic process
NRK99_RS10470	COG2203	Gaf domain
NRK99_RS10470	COG2199	diguanylate cyclase activity
NRK99_RS10480	COG0417	DNA replication proofreading
NRK99_RS10510	COG0534	Mate efflux family protein
NRK99_RS10520	COG0307	riboflavin synthase, alpha
NRK99_RS10530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRK99_RS10535	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NRK99_RS10540	COG0697	spore germination
NRK99_RS10545	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NRK99_RS10590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NRK99_RS10595	COG3099	Belongs to the UPF0263 family
NRK99_RS10600	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NRK99_RS10605	COG2894	cell division
NRK99_RS10610	COG0850	regulation of cytokinetic process
NRK99_RS10615	COG3100	YcgL domain-containing protein
NRK99_RS10620	COG2951	lytic endotransglycosylase activity
NRK99_RS10625	COG1760	l-serine dehydratase
NRK99_RS10630	COG1760	l-serine dehydratase
NRK99_RS10635	COG3123	guanosine phosphorylase activity
NRK99_RS10655	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NRK99_RS10660	COG2067	long-chain fatty acid transport protein
NRK99_RS10675	COG1595	DNA-templated transcription, initiation
NRK99_RS10705	COG0714	Associated with various cellular activities
NRK99_RS10710	COG0183	Belongs to the thiolase family
NRK99_RS10715	COG1024	Enoyl-CoA hydratase
NRK99_RS10715	COG1250	3-hydroxyacyl-CoA dehydrogenase
NRK99_RS10745	COG3829	transcription factor binding
NRK99_RS10750	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NRK99_RS10755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NRK99_RS10760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NRK99_RS10770	COG0549	Belongs to the carbamate kinase family
NRK99_RS10775	COG0697	spore germination
NRK99_RS10780	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NRK99_RS10780	COG3608	succinylglutamate desuccinylase aspartoacylase
NRK99_RS10785	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NRK99_RS10790	COG2068	MobA-Related Protein
NRK99_RS10795	COG0493	'glutamate synthase
NRK99_RS10795	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRK99_RS10800	COG0402	S-adenosylhomocysteine deaminase activity
NRK99_RS10805	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NRK99_RS10810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NRK99_RS10810	COG2080	2 iron, 2 sulfur cluster binding
NRK99_RS10815	COG2233	PERMEase
NRK99_RS10820	COG0402	S-adenosylhomocysteine deaminase activity
NRK99_RS10825	COG2252	PERMEase
NRK99_RS10830	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NRK99_RS10835	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NRK99_RS10840	COG2080	2 iron, 2 sulfur cluster binding
NRK99_RS10850	COG3134	Outer membrane lipoprotein
NRK99_RS10860	COG1288	antiporter activity
NRK99_RS10865	COG0318	PFAM AMP-dependent synthetase and ligase
NRK99_RS10875	COG0140	phosphoribosyl-ATP diphosphatase activity
NRK99_RS10875	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NRK99_RS10880	COG0107	imidazoleglycerol-phosphate synthase activity
NRK99_RS10885	COG0784	Response regulator, receiver
NRK99_RS10885	COG2198	Histidine kinase
NRK99_RS10885	COG2205	protein histidine kinase activity
NRK99_RS10890	COG2199	diguanylate cyclase activity
NRK99_RS10895	COG3437	response regulator, receiver
NRK99_RS10900	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NRK99_RS10905	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NRK99_RS10910	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NRK99_RS10910	COG0131	Imidazoleglycerol-phosphate dehydratase
NRK99_RS10915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NRK99_RS10920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NRK99_RS10925	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NRK99_RS10935	COG1199	ATP-dependent helicase activity
NRK99_RS10940	COG1214	PFAM Peptidase M22, glycoprotease
NRK99_RS10955	COG0318	PFAM AMP-dependent synthetase and ligase
NRK99_RS10960	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NRK99_RS10975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NRK99_RS10980	COG2832	Protein of unknown function (DUF454)
NRK99_RS10985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NRK99_RS10995	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NRK99_RS11000	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
NRK99_RS11010	COG3314	Sporulation integral membrane protein YlbJ
NRK99_RS11020	COG0517	IMP dehydrogenase activity
NRK99_RS11020	COG0617	tRNA 3'-terminal CCA addition
NRK99_RS11020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NRK99_RS11025	COG1643	Atp-dependent helicase
NRK99_RS11035	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NRK99_RS11045	COG3437	response regulator, receiver
NRK99_RS11050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRK99_RS11055	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
NRK99_RS11060	COG0709	Synthesizes selenophosphate from selenide and ATP
NRK99_RS11075	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NRK99_RS11080	COG0840	transmembrane signaling receptor activity
NRK99_RS11085	COG1254	Belongs to the acylphosphatase family
NRK99_RS11090	COG0625	glutathione transferase activity
NRK99_RS11095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRK99_RS11095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRK99_RS11100	COG0489	protein tyrosine kinase activity
NRK99_RS11105	COG0572	uridine kinase
NRK99_RS11110	COG0717	Belongs to the dCTP deaminase family
NRK99_RS11115	COG0306	phosphate transporter
NRK99_RS11120	COG1530	ribonuclease E activity
NRK99_RS11130	COG0546	phosphoglycolate phosphatase activity
NRK99_RS11135	COG0424	maF-like protein
NRK99_RS11145	COG1399	metal-binding, possibly nucleic acid-binding protein
NRK99_RS11150	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NRK99_RS11155	COG0416	fatty acid biosynthetic process
NRK99_RS11160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NRK99_RS11170	COG1028	Short-chain dehydrogenase reductase Sdr
NRK99_RS11175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRK99_RS11185	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NRK99_RS11190	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NRK99_RS11195	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NRK99_RS11200	COG0470	DNA polymerase III
NRK99_RS11205	COG0084	hydrolase, TatD family'
NRK99_RS11220	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
NRK99_RS11220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NRK99_RS11225	COG3008	intermembrane lipid transfer
NRK99_RS11230	COG2995	paraquat-inducible protein a
NRK99_RS11240	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NRK99_RS11245	COG0372	Belongs to the citrate synthase family
NRK99_RS11290	COG4221	oxidoreductase activity
NRK99_RS11300	COG3141	response to X-ray
NRK99_RS11325	COG4128	Pfam Zonular occludens toxin
NRK99_RS11370	COG1067	ATP-dependent peptidase activity
NRK99_RS11375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NRK99_RS11390	COG0488	(ABC) transporter
NRK99_RS11400	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NRK99_RS11400	COG0116	Belongs to the methyltransferase superfamily
NRK99_RS11410	COG0167	dihydroorotate dehydrogenase activity
NRK99_RS11415	COG2902	Dehydrogenase
NRK99_RS11425	COG0308	aminopeptidase N
NRK99_RS11435	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
NRK99_RS11440	COG1956	GAF domain-containing protein
NRK99_RS11450	COG3278	Belongs to the heme-copper respiratory oxidase family
NRK99_RS11465	COG2010	Cytochrome c
NRK99_RS11490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NRK99_RS11495	COG0589	response to stress
NRK99_RS11500	COG0037	tRNA processing
NRK99_RS11515	COG0625	glutathione transferase activity
NRK99_RS11520	COG1869	D-ribose catabolic process
NRK99_RS11525	COG1129	ABC transporter
NRK99_RS11530	COG1172	Belongs to the binding-protein-dependent transport system permease family
NRK99_RS11535	COG1879	ABC-type sugar transport system periplasmic component
NRK99_RS11540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRK99_RS11545	COG1609	Transcriptional regulator
NRK99_RS11550	COG2199	diguanylate cyclase activity
NRK99_RS11575	COG0784	Response regulator, receiver
NRK99_RS11575	COG2205	protein histidine kinase activity
NRK99_RS11580	COG0776	regulation of translation
NRK99_RS11585	COG0072	phenylalanine-tRNA ligase activity
NRK99_RS11585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRK99_RS11590	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NRK99_RS11595	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NRK99_RS11600	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NRK99_RS11605	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NRK99_RS11610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NRK99_RS11635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NRK99_RS11645	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NRK99_RS11655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NRK99_RS11660	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
NRK99_RS11665	COG3313	Fe-S protein
NRK99_RS11670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRK99_RS11670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRK99_RS11670	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NRK99_RS11675	COG1105	Belongs to the carbohydrate kinase PfkB family
NRK99_RS11680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRK99_RS11680	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRK99_RS11685	COG1609	Transcriptional regulator
NRK99_RS11690	COG0814	amino acid
NRK99_RS11705	COG0513	Belongs to the DEAD box helicase family
NRK99_RS11715	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NRK99_RS11720	COG2890	protein-(glutamine-N5) methyltransferase activity
NRK99_RS11725	COG2840	Smr protein MutS2
NRK99_RS11735	COG3706	GGDEF domain
NRK99_RS11740	COG0588	phosphoglycerate mutase activity
NRK99_RS11765	COG2824	Alkylphosphonate utilization operon protein PhnA
NRK99_RS11785	COG0384	phenazine biosynthesis protein PhzF
NRK99_RS11810	COG0242	peptide deformylase activity
NRK99_RS11835	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NRK99_RS11845	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NRK99_RS11850	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
NRK99_RS11860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NRK99_RS11865	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NRK99_RS11875	COG0205	6-phosphofructokinase activity
NRK99_RS11880	COG1473	amidohydrolase
NRK99_RS11885	COG1011	Hydrolase
NRK99_RS11890	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NRK99_RS11945	COG3593	DNA synthesis involved in DNA repair
NRK99_RS11965	COG0583	DNA-binding transcription factor activity
NRK99_RS11970	COG0730	response to heat
NRK99_RS11975	COG3148	PFAM DTW domain containing protein
NRK99_RS11985	COG1181	Belongs to the D-alanine--D-alanine ligase family
NRK99_RS11995	COG0386	Belongs to the glutathione peroxidase family
NRK99_RS12000	COG0513	Belongs to the DEAD box helicase family
NRK99_RS12045	COG2329	Antibiotic biosynthesis monooxygenase
NRK99_RS12050	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
NRK99_RS12080	COG2501	S4 domain
NRK99_RS12095	COG1132	(ABC) transporter
NRK99_RS12100	COG1132	(ABC) transporter
NRK99_RS12110	COG3118	belongs to the thioredoxin family
NRK99_RS12115	COG0471	metal ion transport
NRK99_RS12120	COG0058	SHG alpha-glucan phosphorylase activity
NRK99_RS12150	COG0814	amino acid
NRK99_RS12155	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
NRK99_RS12160	COG0514	ATP-dependent DNA helicase (RecQ)
NRK99_RS12165	COG2766	serine protein kinase
NRK99_RS12170	COG2718	Belongs to the UPF0229 family
NRK99_RS12175	COG2719	SpoVR family
NRK99_RS12180	COG2186	Transcriptional regulator
NRK99_RS12185	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NRK99_RS12190	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NRK99_RS12195	COG0586	Pfam SNARE associated Golgi protein
NRK99_RS12205	COG0556	nucleotide-excision repair
NRK99_RS12215	COG0569	domain protein
NRK99_RS12215	COG2985	domain, Protein
NRK99_RS12220	COG0739	heme binding
NRK99_RS12220	COG0741	lytic transglycosylase activity
NRK99_RS12220	COG1196	nuclear chromosome segregation
NRK99_RS12225	COG3181	Tripartite tricarboxylate transporter family receptor
NRK99_RS12240	COG4565	transcriptional regulatory protein
NRK99_RS12245	COG3290	protein histidine kinase activity
NRK99_RS12250	COG1846	Transcriptional regulator
NRK99_RS12250	COG1940	carbohydrate kinase activity
NRK99_RS12255	COG0840	transmembrane signaling receptor activity
NRK99_RS12260	COG3012	SEC-C Motif Domain Protein
NRK99_RS12265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NRK99_RS12270	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
NRK99_RS12275	COG0247	lactate metabolic process
NRK99_RS12290	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
NRK99_RS12295	COG0437	4 iron, 4 sulfur cluster binding
NRK99_RS12300	COG3301	Polysulphide reductase, NrfD
NRK99_RS12305	COG1138	Cytochrome C-type biogenesis protein
NRK99_RS12315	COG3088	subunit of a heme lyase
NRK99_RS12315	COG4235	cytochrome complex assembly
NRK99_RS12330	COG3033	Beta-eliminating lyase
NRK99_RS12340	COG3046	protein related to deoxyribodipyrimidine photolyase
NRK99_RS12345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRK99_RS12350	COG0516	GMP reductase activity
NRK99_RS12350	COG0517	IMP dehydrogenase activity
NRK99_RS12365	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NRK99_RS12380	COG4774	siderophore transport
NRK99_RS12385	COG4977	sequence-specific DNA binding
NRK99_RS12395	COG0583	DNA-binding transcription factor activity
NRK99_RS12400	COG2910	NAD(P)H-binding
NRK99_RS12415	COG0612	Peptidase, M16
NRK99_RS12420	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NRK99_RS12430	COG1944	ATP diphosphatase activity
NRK99_RS12435	COG2116	formate transmembrane transporter activity
NRK99_RS12440	COG1882	Formate acetyltransferase
NRK99_RS12445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRK99_RS12450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NRK99_RS12455	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NRK99_RS12465	COG1840	ABC-type Fe3 transport system, periplasmic component
NRK99_RS12470	COG3842	ATPase activity
NRK99_RS12480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRK99_RS12485	COG2983	Belongs to the UPF0260 family
NRK99_RS12490	COG2801	Transposase and inactivated derivatives
NRK99_RS12500	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NRK99_RS12505	COG0045	succinate-CoA ligase (ADP-forming) activity
NRK99_RS12510	COG0508	dehydrogenase complex catalyzes the overall conversion of
NRK99_RS12515	COG0567	Dehydrogenase, E1 component
NRK99_RS12530	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NRK99_RS12555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NRK99_RS12560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRK99_RS12560	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NRK99_RS12570	COG3069	C4-dicarboxylate transmembrane transporter activity
NRK99_RS12585	COG1451	nucleotide metabolic process
NRK99_RS12600	COG0254	rRNA binding
NRK99_RS12605	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NRK99_RS12615	COG0583	DNA-binding transcription factor activity
NRK99_RS12620	COG2925	Exonuclease
NRK99_RS12630	COG3345	alpha-galactosidase
NRK99_RS12635	COG1380	Effector of murein hydrolase LrgA
NRK99_RS12640	COG1346	cytolysis
NRK99_RS12645	COG0295	cytidine deaminase activity
NRK99_RS12650	COG1022	Amp-dependent synthetase and ligase
NRK99_RS12665	COG0861	Integral membrane protein TerC family
NRK99_RS12670	COG2885	chlorophyll binding
NRK99_RS12695	COG2154	pterin-4-alpha-carbinolamine dehydratase
NRK99_RS12705	COG3768	UPF0283 membrane protein
NRK99_RS12710	COG3106	COG3106 Predicted ATPase
NRK99_RS12725	COG1842	Phage shock protein A
NRK99_RS12730	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NRK99_RS12740	COG4168	peptide transport system, permease
NRK99_RS12745	COG4171	peptide transport system, permease
NRK99_RS12755	COG4172	Belongs to the ABC transporter superfamily
NRK99_RS12765	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NRK99_RS12770	COG1286	toxin biosynthetic process
NRK99_RS12775	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NRK99_RS12780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NRK99_RS12785	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NRK99_RS12790	COG0531	amino acid
NRK99_RS12790	COG1674	ftsk spoiiie
NRK99_RS12800	COG0492	ferredoxin-NADP+ reductase activity
NRK99_RS12805	COG3706	GGDEF domain
NRK99_RS12810	COG3134	Outer membrane lipoprotein
NRK99_RS12815	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NRK99_RS12820	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
NRK99_RS12825	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NRK99_RS12830	COG0542	response to heat
NRK99_RS12835	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NRK99_RS12840	COG1278	Cold shock
NRK99_RS12845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NRK99_RS12870	COG2801	Transposase and inactivated derivatives
NRK99_RS12925	COG3829	transcription factor binding
NRK99_RS12995	COG3209	COG3209 Rhs family protein
NRK99_RS13030	COG1435	thymidine kinase activity
NRK99_RS13035	COG1757	Na H antiporter
NRK99_RS13040	COG2916	Histone family protein nucleoid-structuring protein H-NS
NRK99_RS13045	COG2096	Adenosyltransferase
NRK99_RS13050	COG3530	Putative quorum-sensing-regulated virulence factor
NRK99_RS13055	COG0602	queuosine metabolic process
NRK99_RS13060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NRK99_RS13080	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NRK99_RS13090	COG0776	regulation of translation
NRK99_RS13095	COG0539	negative regulation of cytoplasmic translation
NRK99_RS13100	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NRK99_RS13105	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NRK99_RS13125	COG0583	DNA-binding transcription factor activity
NRK99_RS13145	COG0778	Nitroreductase
NRK99_RS13150	COG5001	Diguanylate cyclase
NRK99_RS13150	COG3300	MHYT domain
NRK99_RS13160	COG0583	DNA-binding transcription factor activity
NRK99_RS13165	COG3437	response regulator, receiver
NRK99_RS13190	COG4989	oxidoreductase activity
NRK99_RS13195	COG0724	RNA recognition motif
NRK99_RS13215	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NRK99_RS13240	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NRK99_RS13245	COG1360	Flagellar Motor Protein
NRK99_RS13250	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRK99_RS13255	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRK99_RS13260	COG0649	NAD binding
NRK99_RS13260	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRK99_RS13275	COG1034	ATP synthesis coupled electron transport
NRK99_RS13280	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NRK99_RS13285	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRK99_RS13290	COG0839	Belongs to the complex I subunit 6 family
NRK99_RS13295	COG0713	ATP synthesis coupled electron transport
NRK99_RS13305	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRK99_RS13310	COG1007	ATP synthesis coupled electron transport
NRK99_RS13325	COG2199	diguanylate cyclase activity
NRK99_RS13325	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NRK99_RS13330	COG0047	phosphoribosylformylglycinamidine synthase activity
NRK99_RS13330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NRK99_RS13335	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NRK99_RS13340	COG1645	bacterial-type flagellum-dependent swarming motility
NRK99_RS13345	COG1160	GTP binding
NRK99_RS13350	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NRK99_RS13355	COG2976	Protein conserved in bacteria
NRK99_RS13360	COG0124	histidyl-tRNA synthetase
NRK99_RS13380	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NRK99_RS13385	COG0105	UTP biosynthetic process
NRK99_RS13390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NRK99_RS13400	COG0633	Ferredoxin
NRK99_RS13405	COG0443	Heat shock 70 kDa protein
NRK99_RS13410	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NRK99_RS13420	COG0822	iron-sulfur transferase activity
NRK99_RS13425	COG1104	cysteine desulfurase activity
NRK99_RS13445	COG3154	lipid carrier protein
NRK99_RS13450	COG0826	peptidase U32
NRK99_RS13455	COG0826	peptidase U32
NRK99_RS13470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRK99_RS13475	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRK99_RS13480	COG1862	Preprotein translocase
NRK99_RS13485	COG0343	queuine tRNA-ribosyltransferase activity
NRK99_RS13490	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NRK99_RS13495	COG0517	IMP dehydrogenase activity
NRK99_RS13505	COG3634	alkyl hydroperoxide reductase activity
NRK99_RS13515	COG3852	Histidine kinase
NRK99_RS13530	COG3119	arylsulfatase activity
NRK99_RS13535	COG0641	radical SAM
NRK99_RS13545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NRK99_RS13550	COG5642	Protein of unknown function (DUF2384)
NRK99_RS13600	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NRK99_RS13600	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NRK99_RS13605	COG0509	glycine decarboxylation via glycine cleavage system
NRK99_RS13610	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NRK99_RS13615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NRK99_RS13620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NRK99_RS13640	COG2814	Major facilitator Superfamily
NRK99_RS13645	COG0625	glutathione transferase activity
NRK99_RS13655	COG0483	inositol monophosphate 1-phosphatase activity
NRK99_RS13675	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NRK99_RS13735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NRK99_RS13735	COG0301	tRNA thio-modification
NRK99_RS13765	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NRK99_RS13790	COG4953	penicillin-binding protein 1C
NRK99_RS13795	COG2373	Large extracellular alpha-helical protein
NRK99_RS13800	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRK99_RS13810	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NRK99_RS13830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRK99_RS13840	COG2431	L-lysine efflux transmembrane transporter activity
NRK99_RS13845	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NRK99_RS13870	COG1393	Belongs to the ArsC family
NRK99_RS13880	COG4783	chaperone-mediated protein folding
NRK99_RS13885	COG0425	Belongs to the sulfur carrier protein TusA family
NRK99_RS13910	COG3842	ATPase activity
NRK99_RS13915	COG3833	ABC-type maltose transport systems, permease component
NRK99_RS13920	COG1175	transmembrane transport
NRK99_RS13930	COG3081	Nucleoid-associated protein
NRK99_RS13935	COG3082	Protein of unknown function (DUF1414)
NRK99_RS13940	COG3083	sulfuric ester hydrolase activity
NRK99_RS13945	COG4771	TonB-dependent receptor
NRK99_RS13950	COG1770	oligopeptidase
NRK99_RS13970	COG4574	serine-type endopeptidase inhibitor activity
NRK99_RS13975	COG3085	chromosome segregation
NRK99_RS13980	COG0583	DNA-binding transcription factor activity
NRK99_RS13985	COG1605	Chorismate mutase
NRK99_RS13985	COG0287	Prephenate dehydrogenase
NRK99_RS13990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NRK99_RS13995	COG0584	glycerophosphoryl diester phosphodiesterase
NRK99_RS14010	COG1349	DNA-binding transcription factor activity
NRK99_RS14015	COG2271	Major facilitator Superfamily
NRK99_RS14020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NRK99_RS14025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NRK99_RS14030	COG0840	transmembrane signaling receptor activity
NRK99_RS14040	COG0583	DNA-binding transcription factor activity
NRK99_RS14070	COG0656	L-ascorbic acid biosynthetic process
NRK99_RS14075	COG2814	Major facilitator Superfamily
NRK99_RS14090	COG3220	belongs to the UPF0276 family
NRK99_RS14110	COG1294	oxidase, subunit
NRK99_RS14120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRK99_RS14130	COG2979	Protein of unknown function (DUF533)
NRK99_RS14160	COG2271	Major facilitator Superfamily
NRK99_RS14165	COG0583	DNA-binding transcription factor activity
NRK99_RS14175	COG2807	transmembrane transport
NRK99_RS14185	COG1187	pseudouridine synthase activity
NRK99_RS14195	COG0346	lactoylglutathione lyase activity
NRK99_RS14205	COG1403	HNH endonuclease
NRK99_RS14215	COG2964	Protein conserved in bacteria
NRK99_RS14220	COG3681	Belongs to the UPF0597 family
NRK99_RS14230	COG0814	amino acid
NRK99_RS14250	COG0583	DNA-binding transcription factor activity
NRK99_RS14255	COG2015	COG2015, Alkyl sulfatase and related hydrolases
NRK99_RS14265	COG1166	arginine decarboxylase activity
NRK99_RS14275	COG2195	Cleaves the N-terminal amino acid of tripeptides
NRK99_RS14305	COG0583	DNA-binding transcription factor activity
NRK99_RS14315	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NRK99_RS14320	COG0840	transmembrane signaling receptor activity
NRK99_RS14325	COG0302	gtp cyclohydrolase
NRK99_RS14335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NRK99_RS14360	COG2267	carboxylic ester hydrolase activity
NRK99_RS14365	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NRK99_RS14380	COG0314	molybdopterin synthase activity
NRK99_RS14385	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NRK99_RS14390	COG0315	cyclic pyranopterin monophosphate synthase activity
NRK99_RS14395	COG0521	Mo-molybdopterin cofactor biosynthetic process
NRK99_RS14400	COG3005	denitrification pathway
NRK99_RS14410	COG0348	domain, Protein
NRK99_RS14415	COG0437	4 iron, 4 sulfur cluster binding
NRK99_RS14420	COG0243	molybdopterin cofactor binding
NRK99_RS14430	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRK99_RS14430	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRK99_RS14435	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NRK99_RS14440	COG3850	Histidine kinase
NRK99_RS14445	COG2197	response regulator
NRK99_RS14455	COG2205	protein histidine kinase activity
NRK99_RS14455	COG0784	Response regulator, receiver
NRK99_RS14475	COG0121	glutamine amidotransferase
NRK99_RS14480	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NRK99_RS14485	COG1960	acyl-CoA dehydrogenase activity
NRK99_RS14490	COG3437	response regulator, receiver
NRK99_RS14490	COG0784	Response regulator, receiver
NRK99_RS14500	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NRK99_RS14505	COG0328	RNA-DNA hybrid ribonuclease activity
NRK99_RS14510	COG2226	methyltransferase
NRK99_RS14515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRK99_RS14520	COG1388	LysM domain
NRK99_RS14520	COG0741	lytic transglycosylase activity
NRK99_RS14525	COG3021	interspecies interaction between organisms
NRK99_RS14535	COG1607	acyl-coa hydrolase
NRK99_RS14550	COG0741	lytic transglycosylase activity
NRK99_RS14560	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NRK99_RS14580	COG2911	Protein conserved in bacteria
NRK99_RS14585	COG0729	surface antigen
NRK99_RS14595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NRK99_RS14600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NRK99_RS14610	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NRK99_RS14620	COG4134	Bacterial extracellular solute-binding protein
NRK99_RS14630	COG4136	ATPase activity
NRK99_RS14635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NRK99_RS14640	COG2951	lytic endotransglycosylase activity
NRK99_RS14655	COG1846	Transcriptional regulator
NRK99_RS14665	COG0033	Phosphoglucomutase
NRK99_RS14670	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
NRK99_RS14675	COG0596	Alpha beta hydrolase
NRK99_RS14690	COG0716	FMN binding
NRK99_RS14700	COG0735	belongs to the Fur family
NRK99_RS14705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NRK99_RS14715	COG1263	PTS System
NRK99_RS14715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRK99_RS14715	COG2190	(PTS) system
NRK99_RS14720	COG0363	glucosamine-6-phosphate deaminase activity
NRK99_RS14725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NRK99_RS14730	COG1846	Transcriptional regulator
NRK99_RS14730	COG1940	carbohydrate kinase activity
NRK99_RS14735	COG2194	sulfuric ester hydrolase activity
NRK99_RS14740	COG0217	transcriptional regulatory protein
NRK99_RS14745	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NRK99_RS14750	COG1801	Protein of unknown function DUF72
NRK99_RS14755	COG4106	trans-aconitate 2-methyltransferase activity
NRK99_RS14760	COG0500	methyltransferase
NRK99_RS14780	COG0450	alkyl hydroperoxide reductase
NRK99_RS14785	COG0583	DNA-binding transcription factor activity
NRK99_RS14795	COG0791	NLP P60 protein
NRK99_RS14810	COG1309	transcriptional regulator
NRK99_RS14850	COG0534	Mate efflux family protein
NRK99_RS14860	COG2841	Protein conserved in bacteria
NRK99_RS14870	COG2366	antibiotic biosynthetic process
NRK99_RS14875	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NRK99_RS14875	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NRK99_RS14875	COG1013	pyruvate-flavodoxin oxidoreductase activity
NRK99_RS14875	COG0674	pyruvate-flavodoxin oxidoreductase activity
NRK99_RS14885	COG0633	Ferredoxin
NRK99_RS14885	COG3217	Mosc domain protein beta barrel domain protein
NRK99_RS14885	COG0633	Ferredoxin
NRK99_RS14885	COG3217	Mosc domain protein beta barrel domain protein
NRK99_RS14895	COG0501	Belongs to the peptidase M48B family
NRK99_RS14900	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NRK99_RS14905	COG2226	methyltransferase
NRK99_RS14905	COG1073	alpha beta
NRK99_RS14910	COG0156	8-amino-7-oxononanoate synthase activity
NRK99_RS14915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NRK99_RS14935	COG0017	Asparaginyl-tRNA synthetase
NRK99_RS14940	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NRK99_RS14955	COG3069	C4-dicarboxylate transmembrane transporter activity
NRK99_RS14965	COG0583	DNA-binding transcription factor activity
NRK99_RS14970	COG1393	Belongs to the ArsC family
NRK99_RS14975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NRK99_RS14980	COG1876	peptidase activity
NRK99_RS14990	COG3263	regulation of cellular component size
NRK99_RS15010	COG1280	lysine exporter protein (LysE YggA)
NRK99_RS15040	COG0564	pseudouridine synthase activity
NRK99_RS15050	COG1454	alcohol dehydrogenase
NRK99_RS15055	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NRK99_RS15060	COG0702	epimerase
NRK99_RS15065	COG2914	Belongs to the UPF0125 (RnfH) family
NRK99_RS15070	COG2867	negative regulation of translational initiation
NRK99_RS15075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NRK99_RS15125	COG0583	DNA-binding transcription factor activity
NRK99_RS15130	COG3048	D-serine ammonia-lyase activity
NRK99_RS15140	COG0659	secondary active sulfate transmembrane transporter activity
NRK99_RS15145	COG0538	isocitrate dehydrogenase activity
NRK99_RS15150	COG2207	Transcriptional regulator
NRK99_RS15170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRK99_RS15185	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NRK99_RS15190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRK99_RS15190	COG1263	PTS System
NRK99_RS15195	COG1609	Transcriptional regulator
NRK99_RS15205	COG0456	acetyltransferase
NRK99_RS15220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRK99_RS15220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRK99_RS15220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRK99_RS15230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRK99_RS15230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRK99_RS15230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRK99_RS15240	COG1187	pseudouridine synthase activity
NRK99_RS15250	COG0482	sulfurtransferase activity
NRK99_RS15255	COG2915	High frequency lysogenization protein hflD homolog
NRK99_RS15260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NRK99_RS15265	COG2850	peptidyl-arginine hydroxylation
NRK99_RS15280	COG3153	acetyltransferase
NRK99_RS15290	COG0625	glutathione transferase activity
NRK99_RS15295	COG0259	pyridoxamine-phosphate oxidase activity
NRK99_RS15310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NRK99_RS15310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NRK99_RS15315	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NRK99_RS15335	COG4235	cytochrome complex assembly
NRK99_RS15335	COG3088	subunit of a heme lyase
NRK99_RS15340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRK99_RS15345	COG1138	Cytochrome C-type biogenesis protein
NRK99_RS15350	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NRK99_RS15355	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NRK99_RS15360	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NRK99_RS15365	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NRK99_RS15380	COG0835	chemotaxis
NRK99_RS15390	COG1192	Involved in chromosome partitioning
NRK99_RS15400	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NRK99_RS15405	COG2201	protein-glutamate methylesterase activity
NRK99_RS15410	COG2198	Histidine kinase
NRK99_RS15410	COG0784	Response regulator, receiver
NRK99_RS15410	COG0643	Histidine kinase
NRK99_RS15415	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
NRK99_RS15440	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NRK99_RS15450	COG1684	flagellar biosynthetic protein fliR
NRK99_RS15505	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NRK99_RS15515	COG1677	Flagellar hook-basal body complex protein FliE
NRK99_RS15535	COG0798	PFAM Bile acid sodium symporter
NRK99_RS15550	COG0640	Transcriptional regulator
NRK99_RS15555	COG1342	Belongs to the UPF0251 family
NRK99_RS15570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NRK99_RS15590	COG1737	Transcriptional regulator
NRK99_RS15595	COG0469	pyruvate kinase activity
NRK99_RS15610	COG1960	acyl-CoA dehydrogenase activity
NRK99_RS15620	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NRK99_RS15630	COG0243	molybdopterin cofactor binding
NRK99_RS15635	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NRK99_RS15640	COG0583	DNA-binding transcription factor activity
NRK99_RS15675	COG1454	alcohol dehydrogenase
NRK99_RS15675	COG1012	belongs to the aldehyde dehydrogenase family
NRK99_RS15685	COG1012	belongs to the aldehyde dehydrogenase family
NRK99_RS15685	COG1454	alcohol dehydrogenase
NRK99_RS15690	COG1882	Formate acetyltransferase
NRK99_RS15695	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NRK99_RS15705	COG4869	propanediol catabolic process
NRK99_RS15725	COG5002	protein histidine kinase activity
NRK99_RS15730	COG0745	RESPONSE REGULATOR receiver
NRK99_RS15735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRK99_RS15740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRK99_RS15760	COG1376	ErfK ybiS ycfS ynhG family protein
NRK99_RS15760	COG1388	LysM domain
NRK99_RS15775	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
NRK99_RS15780	COG0791	NLP P60 protein
NRK99_RS15790	COG3118	belongs to the thioredoxin family
NRK99_RS15800	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NRK99_RS15805	COG0788	formyltetrahydrofolate deformylase activity
NRK99_RS15815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NRK99_RS15835	COG0366	Alpha amylase catalytic
NRK99_RS15840	COG0739	heme binding
NRK99_RS15840	COG1196	nuclear chromosome segregation
NRK99_RS15840	COG0741	lytic transglycosylase activity
NRK99_RS15845	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NRK99_RS15850	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NRK99_RS15910	COG1032	radical SAM domain protein
NRK99_RS15920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRK99_RS15925	COG1566	PFAM secretion protein HlyD family protein
NRK99_RS15935	COG1752	Esterase of the alpha-beta hydrolase superfamily
NRK99_RS15940	COG0733	neurotransmitter:sodium symporter activity
NRK99_RS15970	COG0281	malic enzyme
NRK99_RS15975	COG2207	Transcriptional regulator
NRK99_RS15980	COG0534	Mate efflux family protein
NRK99_RS15995	COG2233	PERMEase
NRK99_RS16000	COG0095	Lipoate-protein ligase
NRK99_RS16010	COG3210	domain, Protein
NRK99_RS16010	COG3210	domain, Protein
NRK99_RS16015	COG2831	hemolysin activation secretion protein
NRK99_RS16020	COG1115	amino acid carrier protein
NRK99_RS16025	COG0019	diaminopimelate decarboxylase activity
NRK99_RS16035	COG0678	peroxiredoxin activity
NRK99_RS16045	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NRK99_RS16055	COG1126	abc transporter atp-binding protein
NRK99_RS16060	COG0765	amino acid transport
NRK99_RS16065	COG4597	amino acid ABC transporter
NRK99_RS16070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRK99_RS16085	COG1131	(ABC) transporter
NRK99_RS16090	COG0545	Peptidyl-prolyl cis-trans isomerase
NRK99_RS16125	COG5002	protein histidine kinase activity
NRK99_RS16130	COG0745	RESPONSE REGULATOR receiver
NRK99_RS16135	COG0346	lactoylglutathione lyase activity
NRK99_RS16140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NRK99_RS16145	COG1960	acyl-CoA dehydrogenase activity
NRK99_RS16150	COG3284	Transcriptional regulator
NRK99_RS16165	COG0697	spore germination
NRK99_RS16170	COG4565	transcriptional regulatory protein
NRK99_RS16175	COG3290	protein histidine kinase activity
NRK99_RS16180	COG0281	malic enzyme
NRK99_RS16195	COG1846	Transcriptional regulator
NRK99_RS16200	COG1566	PFAM secretion protein HlyD family protein
NRK99_RS16230	COG0602	queuosine metabolic process
NRK99_RS16235	COG1328	CTP reductase activity
NRK99_RS16245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NRK99_RS16250	COG3115	cell septum assembly
NRK99_RS16255	COG1196	nuclear chromosome segregation
NRK99_RS16265	COG2860	membrane
NRK99_RS16275	COG3108	Peptidase M15
NRK99_RS16280	COG2989	Protein conserved in bacteria
NRK99_RS16295	COG0463	Glycosyl transferase, family 2
NRK99_RS16310	COG0366	Alpha amylase catalytic
NRK99_RS16345	COG3706	GGDEF domain
NRK99_RS16355	COG3590	peptidase
NRK99_RS16365	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NRK99_RS16375	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NRK99_RS16380	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NRK99_RS16410	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NRK99_RS16415	COG0583	DNA-binding transcription factor activity
NRK99_RS16435	COG0583	DNA-binding transcription factor activity
NRK99_RS16450	COG0739	heme binding
NRK99_RS16460	COG1511	domain protein
NRK99_RS16460	COG3264	Mechanosensitive ion channel
NRK99_RS16465	COG0584	glycerophosphoryl diester phosphodiesterase
NRK99_RS16475	COG1053	succinate dehydrogenase
NRK99_RS16480	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NRK99_RS16485	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
NRK99_RS16510	COG3214	Protein conserved in bacteria
NRK99_RS16550	COG0642	Histidine kinase
NRK99_RS16570	COG0516	GMP reductase activity
NRK99_RS16580	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NRK99_RS16585	COG3647	Membrane
NRK99_RS16595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NRK99_RS16615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRK99_RS16630	COG3706	GGDEF domain
NRK99_RS16640	COG1335	isochorismatase
NRK99_RS16645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NRK99_RS16650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NRK99_RS16655	COG1702	phosphate starvation-inducible protein PhoH
NRK99_RS16660	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NRK99_RS16665	COG4535	Mg2 and Co2 transporter CorC
NRK99_RS16670	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NRK99_RS16675	COG2888	peptidyl-tyrosine sulfation
NRK99_RS16680	COG0495	leucyl-tRNA aminoacylation
NRK99_RS16695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NRK99_RS16700	COG0799	negative regulation of ribosome biogenesis
NRK99_RS16705	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NRK99_RS16710	COG0768	penicillin binding
NRK99_RS16715	COG0772	Belongs to the SEDS family
NRK99_RS16720	COG2951	lytic endotransglycosylase activity
NRK99_RS16725	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NRK99_RS16730	COG1686	Belongs to the peptidase S11 family
NRK99_RS16735	COG2921	Belongs to the UPF0250 family
NRK99_RS16740	COG0321	lipoyl(octanoyl) transferase activity
NRK99_RS16745	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NRK99_RS16750	COG3545	Serine hydrolase
NRK99_RS16770	COG0789	Transcriptional regulator
NRK99_RS16775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NRK99_RS16785	COG1970	mechanosensitive ion channel activity
NRK99_RS16795	COG4974	Belongs to the 'phage' integrase family
NRK99_RS16805	COG0312	modulator of DNA gyrase
NRK99_RS16810	COG0312	modulator of DNA gyrase
NRK99_RS16855	COG0114	fumarate hydratase activity
NRK99_RS16865	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NRK99_RS16870	COG3706	GGDEF domain
NRK99_RS16875	COG2211	Major facilitator Superfamily
NRK99_RS16880	COG1185	polyribonucleotide nucleotidyltransferase activity
NRK99_RS16885	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NRK99_RS16890	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NRK99_RS16895	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NRK99_RS16900	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NRK99_RS16905	COG0195	Participates in both transcription termination and antitermination
NRK99_RS16910	COG0779	Required for maturation of 30S ribosomal subunits
NRK99_RS16925	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NRK99_RS16930	COG0149	triose-phosphate isomerase activity
NRK99_RS16935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NRK99_RS16940	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NRK99_RS16950	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NRK99_RS16955	COG1534	Rna-binding protein
NRK99_RS16970	COG1360	Flagellar Motor Protein
NRK99_RS16975	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NRK99_RS16980	COG1722	exodeoxyribonuclease VII activity
NRK99_RS16985	COG0142	geranyltranstransferase activity
NRK99_RS16990	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NRK99_RS16995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRK99_RS17000	COG0601	transmembrane transport
NRK99_RS17010	COG4172	Belongs to the ABC transporter superfamily
NRK99_RS17015	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NRK99_RS17020	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NRK99_RS17025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NRK99_RS17045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NRK99_RS17045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NRK99_RS17050	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NRK99_RS17065	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NRK99_RS17075	COG2205	protein histidine kinase activity
NRK99_RS17075	COG2198	Histidine kinase
NRK99_RS17075	COG0784	Response regulator, receiver
NRK99_RS17080	COG1879	ABC-type sugar transport system periplasmic component
NRK99_RS17090	COG0745	RESPONSE REGULATOR receiver
NRK99_RS17095	COG3005	denitrification pathway
NRK99_RS17105	COG3381	protein complex oligomerization
NRK99_RS17125	COG3300	MHYT domain
NRK99_RS17125	COG5001	Diguanylate cyclase
NRK99_RS17135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NRK99_RS17140	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NRK99_RS17145	COG0511	ligase activity, forming carbon-carbon bonds
NRK99_RS17150	COG0439	Biotin carboxylase
NRK99_RS17155	COG3924	membrane
NRK99_RS17160	COG4145	pantothenate transmembrane transporter activity
NRK99_RS17165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRK99_RS17165	COG2190	(PTS) system
NRK99_RS17165	COG1263	PTS System
NRK99_RS17170	COG0583	DNA-binding transcription factor activity
NRK99_RS17175	COG0604	alcohol dehydrogenase
NRK99_RS17180	COG2264	protein methyltransferase activity
NRK99_RS17195	COG0778	Nitroreductase
NRK99_RS17200	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRK99_RS17200	COG1902	pentaerythritol trinitrate reductase activity
NRK99_RS17205	COG0616	signal peptide processing
NRK99_RS17225	COG3139	Protein of unknown function (DUF1315)
NRK99_RS17230	COG0252	asparaginase activity
NRK99_RS17235	COG0786	glutamate:sodium symporter activity
NRK99_RS17250	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NRK99_RS17255	COG0384	phenazine biosynthesis protein PhzF
NRK99_RS17260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NRK99_RS17265	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NRK99_RS17270	COG0175	sulfate reduction
NRK99_RS17275	COG2113	Glycine betaine
NRK99_RS17280	COG4176	ABC-type proline glycine betaine transport system permease component
NRK99_RS17285	COG4175	Glycine betaine
NRK99_RS17295	COG3610	response to peptide
NRK99_RS17300	COG2966	Psort location CytoplasmicMembrane, score
NRK99_RS17310	COG0521	Mo-molybdopterin cofactor biosynthetic process
NRK99_RS17320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NRK99_RS17325	COG1028	Short-chain dehydrogenase reductase Sdr
NRK99_RS17335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NRK99_RS17360	COG2986	histidine ammonia-lyase
NRK99_RS17370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NRK99_RS17385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRK99_RS17390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRK99_RS17425	COG1858	cytochrome C peroxidase
NRK99_RS17435	COG2313	pseudouridylate synthase activity
NRK99_RS17440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRK99_RS17485	COG1073	alpha beta
NRK99_RS17490	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NRK99_RS17495	COG2195	Cleaves the N-terminal amino acid of tripeptides
NRK99_RS17500	COG4608	Belongs to the ABC transporter superfamily
NRK99_RS17505	COG0444	Belongs to the ABC transporter superfamily
NRK99_RS17515	COG4239	(ABC) transporter, permease
NRK99_RS17520	COG4174	ABC transporter (Permease)
NRK99_RS17535	COG0811	peptide transport
NRK99_RS17540	COG0811	peptide transport
NRK99_RS17545	COG0848	biopolymer transport protein
NRK99_RS17595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NRK99_RS17600	COG0840	transmembrane signaling receptor activity
NRK99_RS17610	COG1278	Cold shock
NRK99_RS17650	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NRK99_RS17655	COG1162	GTPase activity
NRK99_RS17660	COG0688	phosphatidylethanolamine metabolic process
NRK99_RS17665	COG4628	conserved protein (DUF2132)
NRK99_RS17685	COG5001	Diguanylate cyclase
NRK99_RS17685	COG3300	MHYT domain
NRK99_RS17690	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
NRK99_RS17725	COG1404	Belongs to the peptidase S8 family
NRK99_RS17730	COG2897	thiosulfate sulfurtransferase activity
NRK99_RS17735	COG2066	Belongs to the glutaminase family
NRK99_RS17740	COG3171	Protein conserved in bacteria
NRK99_RS17745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NRK99_RS17750	COG2234	aminopeptidase activity
NRK99_RS17750	COG4935	Belongs to the peptidase S8 family
NRK99_RS17755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRK99_RS17760	COG2200	EAL domain
NRK99_RS17765	COG1090	epimerase
NRK99_RS17775	COG4181	ATPase activity
NRK99_RS17780	COG2755	lipolytic protein G-D-S-L family
NRK99_RS17785	COG0835	chemotaxis
NRK99_RS17785	COG0784	Response regulator, receiver
NRK99_RS17805	COG2985	domain, Protein
NRK99_RS17805	COG0569	domain protein
NRK99_RS17810	COG1272	protein, Hemolysin III
NRK99_RS17815	COG0076	glutamate decarboxylase activity
NRK99_RS17820	COG2917	probably involved in intracellular septation
NRK99_RS17825	COG2350	Protein conserved in bacteria
NRK99_RS17830	COG1218	3'(2'),5'-bisphosphate nucleotidase
NRK99_RS17835	COG1555	photosystem II stabilization
NRK99_RS17840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NRK99_RS17845	COG3104	oligopeptide transport
NRK99_RS17850	COG0745	RESPONSE REGULATOR receiver
NRK99_RS17880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRK99_RS17895	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NRK99_RS17925	COG0316	Belongs to the HesB IscA family
NRK99_RS17935	COG0038	chloride channel
NRK99_RS17940	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NRK99_RS17955	COG0671	phosphoesterase, PA-phosphatase related
NRK99_RS17965	COG3437	response regulator, receiver
NRK99_RS17965	COG0784	Response regulator, receiver
NRK99_RS17975	COG2076	Multidrug Resistance protein
NRK99_RS17985	COG0346	lactoylglutathione lyase activity
NRK99_RS17990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NRK99_RS17995	COG1643	Atp-dependent helicase
NRK99_RS18005	COG1489	DNA binding
NRK99_RS18010	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NRK99_RS18015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NRK99_RS18025	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NRK99_RS18030	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NRK99_RS18035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NRK99_RS18065	COG1924	4 iron, 4 sulfur cluster binding
NRK99_RS18070	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
NRK99_RS18075	COG0842	Transport permease protein
NRK99_RS18080	COG1131	(ABC) transporter
NRK99_RS18095	COG0163	prenyltransferase activity
NRK99_RS18100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NRK99_RS18105	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NRK99_RS18120	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
NRK99_RS18135	COG1136	(ABC) transporter
NRK99_RS18155	COG0840	transmembrane signaling receptor activity
NRK99_RS18160	COG0625	glutathione transferase activity
NRK99_RS18180	COG2801	Transposase and inactivated derivatives
NRK99_RS18185	COG0529	Catalyzes the synthesis of activated sulfate
NRK99_RS18190	COG0471	metal ion transport
NRK99_RS18190	COG3273	potassium ion transport
NRK99_RS18195	COG2895	sulfate adenylyltransferase (ATP) activity
NRK99_RS18200	COG0175	sulfate reduction
NRK99_RS18205	COG1648	precorrin-2 dehydrogenase activity
NRK99_RS18205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NRK99_RS18210	COG0330	HflC and HflK could
NRK99_RS18215	COG1585	Membrane protein implicated in regulation of membrane protease activity
NRK99_RS18220	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NRK99_RS18220	COG0517	IMP dehydrogenase activity
NRK99_RS18225	COG0488	(ABC) transporter
NRK99_RS18235	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NRK99_RS18270	COG2801	Transposase and inactivated derivatives
NRK99_RS18275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NRK99_RS18285	COG0668	transmembrane transport
NRK99_RS18295	COG2731	YhcH YjgK YiaL family protein
NRK99_RS18310	COG1794	racemase activity, acting on amino acids and derivatives
NRK99_RS18325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRK99_RS18350	COG0733	neurotransmitter:sodium symporter activity
NRK99_RS18360	COG0733	neurotransmitter:sodium symporter activity
NRK99_RS18375	COG0561	phosphatase activity
NRK99_RS18405	COG1846	Transcriptional regulator
NRK99_RS18410	COG2130	NADP-dependent
NRK99_RS18415	COG1051	belongs to the nudix hydrolase family
NRK99_RS18435	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NRK99_RS18440	COG1640	4-alpha-glucanotransferase
NRK99_RS18445	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NRK99_RS18450	COG0676	glucose-6-phosphate 1-epimerase activity
NRK99_RS18455	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NRK99_RS18460	COG0840	transmembrane signaling receptor activity
NRK99_RS18535	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
NRK99_RS18540	COG2885	chlorophyll binding
NRK99_RS18545	COG0823	Involved in the tonB-independent uptake of proteins
NRK99_RS18560	COG0811	peptide transport
NRK99_RS18565	COG0824	Thioesterase
NRK99_RS18570	COG3790	cyd operon protein YbgE
NRK99_RS18575	COG4890	Cyd operon protein YbgT
NRK99_RS18580	COG1294	oxidase, subunit
NRK99_RS18585	COG1271	oxidase subunit
NRK99_RS18590	COG2255	four-way junction helicase activity
NRK99_RS18595	COG0632	four-way junction helicase activity
NRK99_RS18600	COG0840	transmembrane signaling receptor activity
NRK99_RS18605	COG0442	prolyl-tRNA aminoacylation
NRK99_RS18610	COG4221	oxidoreductase activity
NRK99_RS18625	COG1024	Enoyl-CoA hydratase
NRK99_RS18635	COG0110	maltose O-acetyltransferase activity
NRK99_RS18645	COG4166	transmembrane transport
NRK99_RS18660	COG1872	DUF167
NRK99_RS18665	COG0762	integral membrane protein
NRK99_RS18670	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NRK99_RS18675	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NRK99_RS18690	COG3022	response to hydroperoxide
NRK99_RS18695	COG0513	Belongs to the DEAD box helicase family
NRK99_RS18700	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NRK99_RS18725	COG0735	belongs to the Fur family
NRK99_RS18730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NRK99_RS18745	COG0776	regulation of translation
NRK99_RS18780	COG0560	Phosphoserine phosphatase
NRK99_RS18790	COG5001	Diguanylate cyclase
NRK99_RS18790	COG3447	MASE1 domain protein
NRK99_RS18790	COG5002	protein histidine kinase activity
NRK99_RS18795	COG0813	purine-nucleoside phosphorylase activity
NRK99_RS18800	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NRK99_RS18805	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NRK99_RS18810	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NRK99_RS18820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRK99_RS18825	COG0084	hydrolase, TatD family'
NRK99_RS18830	COG2165	general secretion pathway protein
NRK99_RS18845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NRK99_RS18850	COG0004	ammonium transporteR
NRK99_RS18855	COG4974	Belongs to the 'phage' integrase family
NRK99_RS18940	COG4695	Portal protein
NRK99_RS19085	COG0795	lipopolysaccharide-transporting ATPase activity
NRK99_RS19090	COG0795	lipopolysaccharide-transporting ATPase activity
NRK99_RS19095	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NRK99_RS19100	COG2927	DNA polymerase III (CHI subunit)
NRK99_RS19105	COG0525	valine-tRNA ligase activity
NRK99_RS19110	COG1253	flavin adenine dinucleotide binding
NRK99_RS19115	COG0586	Pfam SNARE associated Golgi protein
NRK99_RS19120	COG1686	Belongs to the peptidase S11 family
NRK99_RS19155	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NRK99_RS19160	COG0527	aspartate kinase activity
NRK99_RS19165	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NRK99_RS19175	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NRK99_RS19180	COG1546	Belongs to the CinA family
NRK99_RS19185	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NRK99_RS19205	COG3068	Protein conserved in bacteria
NRK99_RS19215	COG0739	heme binding
NRK99_RS19235	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
NRK99_RS19240	COG1121	(ABC) transporter
NRK99_RS19245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NRK99_RS19250	COG0583	DNA-binding transcription factor activity
NRK99_RS19255	COG0697	spore germination
NRK99_RS19260	COG1573	uracil-dna glycosylase
NRK99_RS19265	COG2962	Rard protein
NRK99_RS19275	COG2827	Endonuclease containing a URI domain
NRK99_RS19290	COG1842	Phage shock protein A
NRK99_RS19295	COG0204	Acyl-transferase
NRK99_RS19315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRK99_RS19370	COG0583	DNA-binding transcription factor activity
NRK99_RS19380	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NRK99_RS19390	COG0583	DNA-binding transcription factor activity
NRK99_RS19410	COG1289	transmembrane transporter activity
NRK99_RS19415	COG1566	PFAM secretion protein HlyD family protein
NRK99_RS19430	COG1051	belongs to the nudix hydrolase family
NRK99_RS19435	COG3150	esterase
NRK99_RS19445	COG3151	Protein conserved in bacteria
NRK99_RS19450	COG0494	nUDIX hydrolase
NRK99_RS19455	COG1538	Outer membrane efflux protein
NRK99_RS19460	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NRK99_RS19460	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NRK99_RS19465	COG1560	Kdo2-lipid A biosynthetic process
NRK99_RS19480	COG1392	Phosphate transport regulator
NRK99_RS19485	COG0306	phosphate transporter
NRK99_RS19490	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NRK99_RS19520	COG0583	DNA-binding transcription factor activity
NRK99_RS19525	COG1380	Effector of murein hydrolase LrgA
NRK99_RS19530	COG1346	cytolysis
NRK99_RS19545	COG0617	tRNA 3'-terminal CCA addition
NRK99_RS19550	COG3267	Type II secretory pathway component ExeA
NRK99_RS19550	COG3409	Peptidoglycan-binding domain 1 protein
NRK99_RS19560	COG1194	a g-specific adenine glycosylase
NRK99_RS19565	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
NRK99_RS19575	COG3111	PFAM Bacterial OB fold (BOF) protein
NRK99_RS19580	COG3240	lipase activity
NRK99_RS19595	COG3009	Protein conserved in bacteria
NRK99_RS19600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NRK99_RS19600	COG3008	intermembrane lipid transfer
NRK99_RS19605	COG2995	paraquat-inducible protein a
NRK99_RS19615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRK99_RS19625	COG4251	negative regulation of phosphorylation
NRK99_RS19625	COG3706	GGDEF domain
NRK99_RS19625	COG2203	Gaf domain
NRK99_RS19625	COG5001	Diguanylate cyclase
NRK99_RS19630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NRK99_RS19635	COG2813	Specifically methylates the guanine in position
NRK99_RS19640	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NRK99_RS19645	COG0297	glycogen (starch) synthase activity
NRK99_RS19680	COG1757	Na H antiporter
NRK99_RS19685	COG0583	DNA-binding transcription factor activity
NRK99_RS19690	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NRK99_RS19695	COG3842	ATPase activity
NRK99_RS19700	COG1176	ABC-type spermidine putrescine transport system, permease component I
NRK99_RS19705	COG1177	transmembrane transport
NRK99_RS19710	COG1012	belongs to the aldehyde dehydrogenase family
NRK99_RS19735	COG0110	maltose O-acetyltransferase activity
NRK99_RS19740	COG0366	Alpha amylase catalytic
NRK99_RS19745	COG1263	PTS System
NRK99_RS19745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRK99_RS19750	COG1609	Transcriptional regulator
NRK99_RS19765	COG0252	asparaginase activity
NRK99_RS19780	COG1803	Methylglyoxal synthase
NRK99_RS19805	COG1444	tRNA N-acetyltransferase activity
NRK99_RS19815	COG0784	Response regulator, receiver
NRK99_RS19815	COG0835	chemotaxis
NRK99_RS19820	COG3314	Sporulation integral membrane protein YlbJ
NRK99_RS19855	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NRK99_RS19860	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NRK99_RS19875	COG0477	Major facilitator Superfamily
NRK99_RS19880	COG0523	cobalamin synthesis protein
NRK99_RS19890	COG1280	lysine exporter protein (LysE YggA)
NRK99_RS19900	COG2200	EAL domain
NRK99_RS19905	COG1049	propionate catabolic process, 2-methylcitrate cycle
NRK99_RS19910	COG1752	Esterase of the alpha-beta hydrolase superfamily
NRK99_RS19915	COG0840	transmembrane signaling receptor activity
NRK99_RS19920	COG0840	transmembrane signaling receptor activity
NRK99_RS19930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NRK99_RS19935	COG0508	dehydrogenase complex catalyzes the overall conversion of
NRK99_RS19940	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NRK99_RS19945	COG2186	Transcriptional regulator
NRK99_RS19970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NRK99_RS19975	COG1459	type II secretion system
NRK99_RS19990	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
NRK99_RS19995	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NRK99_RS20000	COG0494	nUDIX hydrolase
NRK99_RS20010	COG0653	protein targeting
NRK99_RS20020	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NRK99_RS20025	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NRK99_RS20030	COG0849	cell division
NRK99_RS20035	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NRK99_RS20040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NRK99_RS20045	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NRK99_RS20050	COG0772	Belongs to the SEDS family
NRK99_RS20055	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NRK99_RS20060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NRK99_RS20065	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NRK99_RS20075	COG0768	penicillin binding
NRK99_RS20080	COG3116	cell division
NRK99_RS20085	COG0275	rRNA processing
NRK99_RS20090	COG2001	Belongs to the MraZ family
NRK99_RS20100	COG0741	lytic transglycosylase activity
NRK99_RS20100	COG1388	LysM domain
NRK99_RS20105	COG1360	Flagellar Motor Protein
NRK99_RS20110	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NRK99_RS20115	COG1191	sigma factor activity
NRK99_RS20140	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NRK99_RS20145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NRK99_RS20150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NRK99_RS20165	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NRK99_RS20170	COG1256	bacterial-type flagellum assembly
NRK99_RS20170	COG4786	Flagellar basal body rod
NRK99_RS20180	COG1706	bacterial-type flagellum-dependent cell motility
NRK99_RS20185	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NRK99_RS20190	COG4786	Flagellar basal body rod
NRK99_RS20200	COG1749	Flagellar hook protein flgE
NRK99_RS20215	COG1815	bacterial-type flagellum-dependent cell motility
NRK99_RS20250	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NRK99_RS20260	COG1677	Flagellar hook-basal body complex protein FliE
NRK99_RS20310	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NRK99_RS20315	COG3107	peptidoglycan biosynthetic process
NRK99_RS20320	COG0792	nuclease activity
NRK99_RS20325	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NRK99_RS20330	COG2823	Periplasmic or secreted lipoprotein
NRK99_RS20335	COG2969	positive regulation of protein catabolic process
NRK99_RS20340	COG0625	glutathione transferase activity
NRK99_RS20345	COG2857	Cytochrome c1
NRK99_RS20350	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NRK99_RS20355	COG0723	plastoquinol--plastocyanin reductase activity
NRK99_RS20360	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NRK99_RS20365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NRK99_RS20370	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NRK99_RS20380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NRK99_RS20385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NRK99_RS20415	COG3964	amidohydrolase
NRK99_RS20430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRK99_RS20430	COG3711	transcriptional antiterminator
NRK99_RS20435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRK99_RS20440	COG1660	Displays ATPase and GTPase activities
NRK99_RS20445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRK99_RS20455	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NRK99_RS20460	COG1137	ATPase activity
NRK99_RS20465	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NRK99_RS20470	COG3117	lipopolysaccharide transmembrane transporter activity
NRK99_RS20475	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NRK99_RS20480	COG0517	IMP dehydrogenase activity
NRK99_RS20480	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NRK99_RS20485	COG1127	ABC transporter
NRK99_RS20490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NRK99_RS20495	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NRK99_RS20500	COG2854	intermembrane phospholipid transfer
NRK99_RS20510	COG5007	Belongs to the BolA IbaG family
NRK99_RS20515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NRK99_RS20520	COG0312	modulator of DNA gyrase
NRK99_RS20525	COG3028	Belongs to the UPF0307 family
NRK99_RS20535	COG2926	Belongs to the UPF0265 family
NRK99_RS20570	COG1396	sequence-specific DNA binding
NRK99_RS20575	COG3135	benzoate transporter
NRK99_RS20600	COG0840	transmembrane signaling receptor activity
NRK99_RS20615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NRK99_RS20620	COG2197	response regulator
NRK99_RS20655	COG4771	TonB-dependent receptor
NRK99_RS20660	COG5001	Diguanylate cyclase
NRK99_RS20660	COG4251	negative regulation of phosphorylation
NRK99_RS20660	COG3706	GGDEF domain
NRK99_RS20660	COG2203	Gaf domain
NRK99_RS20705	COG0346	lactoylglutathione lyase activity
NRK99_RS20715	COG0583	DNA-binding transcription factor activity
NRK99_RS20730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NRK99_RS20735	COG1074	ATP-dependent DNA helicase activity
NRK99_RS20740	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NRK99_RS20745	COG2259	Doxx family
NRK99_RS20750	COG1741	Belongs to the pirin family
NRK99_RS20760	COG0583	DNA-binding transcription factor activity
NRK99_RS20785	COG1175	transmembrane transport
NRK99_RS20795	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NRK99_RS20805	COG3706	GGDEF domain
NRK99_RS20825	COG1247	-acetyltransferase
NRK99_RS20850	COG0671	phosphoesterase, PA-phosphatase related
NRK99_RS20855	COG0628	permease
NRK99_RS20870	COG2957	Belongs to the agmatine deiminase family
NRK99_RS20875	COG0583	DNA-binding transcription factor activity
NRK99_RS20880	COG3284	Transcriptional regulator
NRK99_RS20895	COG1461	Dihydroxyacetone kinase
NRK99_RS20900	COG2376	Dihydroxyacetone kinase
NRK99_RS20905	COG2252	PERMEase
NRK99_RS20940	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NRK99_RS20945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NRK99_RS20950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NRK99_RS20955	COG0049	tRNA binding
NRK99_RS20960	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NRK99_RS20965	COG2168	tRNA wobble position uridine thiolation
NRK99_RS20980	COG0251	oxidation-reduction process
NRK99_RS20985	COG2964	Protein conserved in bacteria
NRK99_RS20990	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NRK99_RS20995	COG0085	RNA polymerase activity
NRK99_RS21000	COG0222	ribosome binding
NRK99_RS21005	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NRK99_RS21010	COG0081	regulation of translation
NRK99_RS21015	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NRK99_RS21020	COG0250	Participates in transcription elongation, termination and antitermination
NRK99_RS21035	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NRK99_RS21060	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NRK99_RS21065	COG0569	domain protein
NRK99_RS21070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NRK99_RS21090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NRK99_RS21095	COG3005	denitrification pathway
NRK99_RS21100	COG0243	molybdopterin cofactor binding
NRK99_RS21130	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
NRK99_RS21145	COG2204	response regulator
NRK99_RS21155	COG2205	protein histidine kinase activity
NRK99_RS21170	COG1028	Short-chain dehydrogenase reductase Sdr
NRK99_RS21175	COG0516	GMP reductase activity
NRK99_RS21175	COG0517	IMP dehydrogenase activity
NRK99_RS21180	COG5413	integral membrane protein
NRK99_RS21190	COG1522	sequence-specific DNA binding
NRK99_RS21195	COG2502	aspartate--ammonia ligase
NRK99_RS21200	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NRK99_RS21205	COG0542	response to heat
NRK99_RS21215	COG0564	pseudouridine synthase activity
NRK99_RS21220	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NRK99_RS21225	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRK99_RS21235	COG3681	Belongs to the UPF0597 family
NRK99_RS21245	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NRK99_RS21250	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NRK99_RS21255	COG1979	alcohol dehydrogenase
NRK99_RS21260	COG2207	Transcriptional regulator
NRK99_RS21265	COG3040	lipid binding
NRK99_RS21280	COG0688	phosphatidylethanolamine metabolic process
NRK99_RS21300	COG0540	Belongs to the ATCase OTCase family
NRK99_RS21305	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
NRK99_RS21310	COG1438	arginine binding
NRK99_RS21315	COG1288	antiporter activity
NRK99_RS21320	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NRK99_RS21370	COG3250	beta-galactosidase activity
NRK99_RS21375	COG1609	Transcriptional regulator
NRK99_RS21380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NRK99_RS21390	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NRK99_RS21395	COG2017	converts alpha-aldose to the beta-anomer
NRK99_RS21400	COG0667	Aldo Keto reductase
NRK99_RS21405	COG1968	undecaprenyl-diphosphatase activity
NRK99_RS21410	COG3806	Anti-sigma factor
NRK99_RS21415	COG1595	DNA-templated transcription, initiation
NRK99_RS21425	COG0018	arginyl-trna synthetase
NRK99_RS21435	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NRK99_RS21440	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NRK99_RS21445	COG0477	Major facilitator Superfamily
NRK99_RS21455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NRK99_RS21465	COG2116	formate transmembrane transporter activity
NRK99_RS21470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NRK99_RS21470	COG1648	precorrin-2 dehydrogenase activity
NRK99_RS21475	COG2239	Acts as a magnesium transporter
NRK99_RS21485	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NRK99_RS21490	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NRK99_RS21500	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NRK99_RS21510	COG0514	ATP-dependent DNA helicase (RecQ)
NRK99_RS21515	COG2050	protein possibly involved in aromatic compounds catabolism
NRK99_RS21530	COG2258	MOSC domain
NRK99_RS21535	COG1177	transmembrane transport
NRK99_RS21540	COG1176	ABC-type spermidine putrescine transport system, permease component I
NRK99_RS21545	COG3842	ATPase activity
NRK99_RS21565	COG0174	glutamine synthetase
NRK99_RS21585	COG3045	CreA protein
NRK99_RS21590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NRK99_RS21595	COG0443	Heat shock 70 kDa protein
NRK99_RS21600	COG3187	Heat shock protein
NRK99_RS21610	COG0366	Alpha amylase catalytic
NRK99_RS21615	COG1086	Polysaccharide biosynthesis protein
NRK99_RS21620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NRK99_RS21630	COG0367	asparagine synthase
NRK99_RS21635	COG0438	transferase activity, transferring glycosyl groups
NRK99_RS21655	COG1215	transferase activity, transferring glycosyl groups
NRK99_RS21670	COG0318	PFAM AMP-dependent synthetase and ligase
NRK99_RS21675	COG1028	Short-chain dehydrogenase reductase Sdr
NRK99_RS21690	COG1083	cytidylyl-transferase
NRK99_RS21700	COG2089	acid synthase
NRK99_RS21720	COG4310	Domain of unknown function (DUF2172)
NRK99_RS21755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NRK99_RS21760	COG0745	RESPONSE REGULATOR receiver
NRK99_RS21765	COG2205	protein histidine kinase activity
NRK99_RS21775	COG0281	malic enzyme
NRK99_RS21780	COG0702	epimerase
NRK99_RS21785	COG0254	rRNA binding
NRK99_RS21790	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NRK99_RS21820	COG0129	dihydroxy-acid dehydratase activity
NRK99_RS21830	COG3978	acetolactate synthase activity
NRK99_RS21840	COG0606	chelatase, subunit chli
NRK99_RS21845	COG0204	Acyl-transferase
NRK99_RS21850	COG0204	Acyl-transferase
NRK99_RS21855	COG1683	Conserved Protein
NRK99_RS21865	COG1335	isochorismatase
NRK99_RS21875	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
NRK99_RS21880	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NRK99_RS21885	COG3639	organic phosphonate transmembrane transporter activity
NRK99_RS21890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NRK99_RS21895	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NRK99_RS21905	COG3084	Protein conserved in bacteria
NRK99_RS21910	COG2203	Gaf domain
NRK99_RS21910	COG3706	GGDEF domain
NRK99_RS21910	COG4251	negative regulation of phosphorylation
NRK99_RS21910	COG5001	Diguanylate cyclase
NRK99_RS21915	COG0789	Transcriptional regulator
NRK99_RS21925	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NRK99_RS21930	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NRK99_RS21935	COG1561	YicC-like family, N-terminal region
NRK99_RS21960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRK99_RS21970	COG2375	cellular response to nickel ion
NRK99_RS21970	COG1132	(ABC) transporter
NRK99_RS21975	COG1132	(ABC) transporter
NRK99_RS21980	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRK99_RS21985	COG4605	iron ion homeostasis
NRK99_RS21990	COG4604	ABC transporter, ATP-binding protein
NRK99_RS21995	COG4607	ABC-type enterochelin transport system periplasmic component
NRK99_RS22000	COG4774	siderophore transport
NRK99_RS22020	COG3306	glycosyltransferase involved in LPS biosynthesis
NRK99_RS22035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRK99_RS22050	COG1063	alcohol dehydrogenase
NRK99_RS22055	COG3245	cytochrome
NRK99_RS22060	COG5001	Diguanylate cyclase
NRK99_RS22060	COG3300	MHYT domain
NRK99_RS22070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NRK99_RS22075	COG2166	iron-sulfur cluster assembly
NRK99_RS22080	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NRK99_RS22110	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
NRK99_RS22115	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NRK99_RS22120	COG1739	Uncharacterized protein family UPF0029
NRK99_RS22125	COG0006	proline dipeptidase activity
NRK99_RS22130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NRK99_RS22135	COG1250	3-hydroxyacyl-CoA dehydrogenase
NRK99_RS22135	COG1024	Enoyl-CoA hydratase
NRK99_RS22140	COG0183	Belongs to the thiolase family
NRK99_RS22165	COG0425	Belongs to the sulfur carrier protein TusA family
NRK99_RS22170	COG0251	oxidation-reduction process
NRK99_RS22180	COG2885	chlorophyll binding
NRK99_RS22185	COG1335	isochorismatase
NRK99_RS22190	COG2818	Glycosylase
NRK99_RS22195	COG0752	glycyl-tRNA synthetase alpha subunit
NRK99_RS22200	COG0751	glycine-tRNA ligase activity
NRK99_RS22215	COG0529	Catalyzes the synthesis of activated sulfate
NRK99_RS22215	COG2046	Belongs to the sulfate adenylyltransferase family
NRK99_RS22250	COG0814	amino acid
NRK99_RS22255	COG0348	domain, Protein
NRK99_RS22260	COG2188	Transcriptional regulator
NRK99_RS22275	COG1609	Transcriptional regulator
NRK99_RS22315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NRK99_RS22340	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NRK99_RS22355	COG3118	belongs to the thioredoxin family
NRK99_RS22360	COG0513	Belongs to the DEAD box helicase family
NRK99_RS22365	COG0248	Ppx GppA phosphatase
NRK99_RS22380	COG0742	ribosomal rna small subunit methyltransferase
NRK99_RS22385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRK99_RS22405	COG0084	hydrolase, TatD family'
NRK99_RS22410	COG0805	protein transport
NRK99_RS22415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NRK99_RS22425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NRK99_RS22430	COG3165	ubiquinone biosynthetic process from chorismate
NRK99_RS22440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NRK99_RS22445	COG0402	S-adenosylhomocysteine deaminase activity
NRK99_RS22490	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
NRK99_RS22495	COG0848	biopolymer transport protein
NRK99_RS22500	COG0811	peptide transport
NRK99_RS22505	COG0811	peptide transport
NRK99_RS22515	COG2771	luxR family
NRK99_RS22520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NRK99_RS22525	COG1349	DNA-binding transcription factor activity
NRK99_RS22530	COG0745	RESPONSE REGULATOR receiver
NRK99_RS22535	COG2205	protein histidine kinase activity
NRK99_RS22545	COG4452	Inner membrane protein CreD
NRK99_RS22550	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NRK99_RS22555	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NRK99_RS22560	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NRK99_RS22565	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NRK99_RS22570	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NRK99_RS22575	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NRK99_RS22580	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NRK99_RS22590	COG0356	it plays a direct role in the translocation of protons across the membrane
NRK99_RS22600	COG1475	DNA binding
NRK99_RS22605	COG1192	Involved in chromosome partitioning
NRK99_RS22610	COG0357	Ribosomal RNA small subunit methyltransferase G
NRK99_RS22615	COG0445	tRNA wobble uridine modification
NRK99_RS22620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NRK99_RS22625	COG4774	siderophore transport
NRK99_RS22630	COG4615	Cyclic peptide transporter
NRK99_RS22635	COG1120	ATPase activity
NRK99_RS22650	COG3550	peptidyl-serine autophosphorylation
NRK99_RS22750	COG4974	Belongs to the 'phage' integrase family
NRK99_RS22755	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NRK99_RS22760	COG0706	membrane insertase activity
NRK99_RS22765	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NRK99_RS22770	COG0594	ribonuclease P activity
NRK99_RS22775	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NRK99_RS22780	COG1126	abc transporter atp-binding protein