locus-tag	class	description
E4630_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4630_RS00010	COG0592	DNA-directed DNA polymerase activity
E4630_RS00030	COG2378	regulation of single-species biofilm formation
E4630_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
E4630_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
E4630_RS00045	COG3977	Valine--pyruvate aminotransferase
E4630_RS00060	COG2814	Major facilitator Superfamily
E4630_RS00065	COG0745	RESPONSE REGULATOR receiver
E4630_RS00070	COG2205	protein histidine kinase activity
E4630_RS00095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4630_RS00100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4630_RS00100	COG4191	Histidine kinase
E4630_RS00105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4630_RS00110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4630_RS00115	COG1309	transcriptional regulator
E4630_RS00145	COG0469	pyruvate kinase activity
E4630_RS00150	COG2271	Major facilitator Superfamily
E4630_RS00175	COG0561	phosphatase activity
E4630_RS00180	COG2267	carboxylic ester hydrolase activity
E4630_RS00190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4630_RS00195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4630_RS00200	COG1758	RNA polymerase activity
E4630_RS00210	COG0859	PFAM glycosyl transferase family 9
E4630_RS00215	COG3642	lipopolysaccharide core region biosynthetic process
E4630_RS00255	COG0589	response to stress
E4630_RS00260	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4630_RS00270	COG1528	Iron-storage protein
E4630_RS00275	COG2081	HI0933 family
E4630_RS00280	COG2223	nitrite transmembrane transporter activity
E4630_RS00300	COG3188	usher protein
E4630_RS00320	COG2205	protein histidine kinase activity
E4630_RS00320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4630_RS00330	COG3275	phosphorelay sensor kinase activity
E4630_RS00335	COG3279	Response regulator of the LytR AlgR family
E4630_RS00340	COG2223	nitrite transmembrane transporter activity
E4630_RS00345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4630_RS00350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4630_RS00365	COG0583	DNA-binding transcription factor activity
E4630_RS00370	COG4206	TonB-dependent receptor
E4630_RS00375	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4630_RS00410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4630_RS00415	COG2166	iron-sulfur cluster assembly
E4630_RS00420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4630_RS00425	COG0210	DNA helicase
E4630_RS00435	COG3245	cytochrome
E4630_RS00440	COG1063	alcohol dehydrogenase
E4630_RS00445	COG0156	8-amino-7-oxononanoate synthase activity
E4630_RS00455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4630_RS00470	COG3306	glycosyltransferase involved in LPS biosynthesis
E4630_RS00490	COG1561	YicC-like family, N-terminal region
E4630_RS00495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E4630_RS00500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4630_RS00510	COG0789	Transcriptional regulator
E4630_RS00515	COG2203	Gaf domain
E4630_RS00515	COG3706	GGDEF domain
E4630_RS00515	COG4251	negative regulation of phosphorylation
E4630_RS00515	COG5001	Diguanylate cyclase
E4630_RS00520	COG3084	Protein conserved in bacteria
E4630_RS00530	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4630_RS00535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4630_RS00545	COG1335	isochorismatase
E4630_RS00555	COG1683	Conserved Protein
E4630_RS00560	COG0204	Acyl-transferase
E4630_RS00565	COG0204	Acyl-transferase
E4630_RS00570	COG0606	chelatase, subunit chli
E4630_RS00585	COG3978	acetolactate synthase activity
E4630_RS00595	COG0129	dihydroxy-acid dehydratase activity
E4630_RS00615	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4630_RS00620	COG0254	rRNA binding
E4630_RS00625	COG0702	epimerase
E4630_RS00630	COG0281	malic enzyme
E4630_RS00640	COG2205	protein histidine kinase activity
E4630_RS00645	COG0745	RESPONSE REGULATOR receiver
E4630_RS00650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4630_RS00685	COG4310	Domain of unknown function (DUF2172)
E4630_RS00705	COG2089	acid synthase
E4630_RS00715	COG1083	cytidylyl-transferase
E4630_RS00730	COG1028	Short-chain dehydrogenase reductase Sdr
E4630_RS00735	COG0318	PFAM AMP-dependent synthetase and ligase
E4630_RS00750	COG1215	transferase activity, transferring glycosyl groups
E4630_RS00760	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E4630_RS00805	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4630_RS00810	COG1086	Polysaccharide biosynthesis protein
E4630_RS00815	COG0366	Alpha amylase catalytic
E4630_RS00830	COG0443	Heat shock 70 kDa protein
E4630_RS00835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4630_RS00840	COG3045	CreA protein
E4630_RS00860	COG0174	glutamine synthetase
E4630_RS00880	COG3842	ATPase activity
E4630_RS00885	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4630_RS00890	COG1177	transmembrane transport
E4630_RS00895	COG2258	MOSC domain
E4630_RS00915	COG2050	protein possibly involved in aromatic compounds catabolism
E4630_RS00920	COG0514	ATP-dependent DNA helicase (RecQ)
E4630_RS00930	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E4630_RS00940	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E4630_RS00945	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4630_RS00955	COG2239	Acts as a magnesium transporter
E4630_RS00960	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4630_RS00960	COG1648	precorrin-2 dehydrogenase activity
E4630_RS00965	COG2116	formate transmembrane transporter activity
E4630_RS00975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4630_RS00990	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4630_RS00995	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4630_RS01015	COG1595	DNA-templated transcription, initiation
E4630_RS01020	COG3806	Anti-sigma factor
E4630_RS01025	COG1968	undecaprenyl-diphosphatase activity
E4630_RS01030	COG0667	Aldo Keto reductase
E4630_RS01035	COG2017	converts alpha-aldose to the beta-anomer
E4630_RS01040	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4630_RS01050	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4630_RS01055	COG1609	Transcriptional regulator
E4630_RS01060	COG3250	beta-galactosidase activity
E4630_RS01110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4630_RS01115	COG1288	antiporter activity
E4630_RS01120	COG1438	arginine binding
E4630_RS01125	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4630_RS01130	COG0540	Belongs to the ATCase OTCase family
E4630_RS01150	COG0688	phosphatidylethanolamine metabolic process
E4630_RS01165	COG3040	lipid binding
E4630_RS01170	COG2207	Transcriptional regulator
E4630_RS01175	COG1979	alcohol dehydrogenase
E4630_RS01180	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4630_RS01185	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4630_RS01195	COG3681	Belongs to the UPF0597 family
E4630_RS01205	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4630_RS01210	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4630_RS01215	COG0564	pseudouridine synthase activity
E4630_RS01230	COG0542	response to heat
E4630_RS01235	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E4630_RS01245	COG2502	aspartate--ammonia ligase
E4630_RS01250	COG1522	sequence-specific DNA binding
E4630_RS01260	COG5413	integral membrane protein
E4630_RS01285	COG2205	protein histidine kinase activity
E4630_RS01295	COG2204	response regulator
E4630_RS01315	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E4630_RS01345	COG0243	molybdopterin cofactor binding
E4630_RS01350	COG3005	denitrification pathway
E4630_RS01355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4630_RS01375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4630_RS01380	COG0569	domain protein
E4630_RS01385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4630_RS01410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4630_RS01425	COG0250	Participates in transcription elongation, termination and antitermination
E4630_RS01430	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4630_RS01435	COG0081	regulation of translation
E4630_RS01440	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4630_RS01445	COG0222	ribosome binding
E4630_RS01450	COG0085	RNA polymerase activity
E4630_RS01455	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4630_RS01460	COG2964	Protein conserved in bacteria
E4630_RS01465	COG0251	oxidation-reduction process
E4630_RS01475	COG2923	Belongs to the DsrF TusC family
E4630_RS01480	COG2168	tRNA wobble position uridine thiolation
E4630_RS01485	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4630_RS01490	COG0049	tRNA binding
E4630_RS01495	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4630_RS01500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4630_RS01505	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4630_RS01545	COG2252	PERMEase
E4630_RS01550	COG2376	Dihydroxyacetone kinase
E4630_RS01555	COG1461	Dihydroxyacetone kinase
E4630_RS01570	COG3284	Transcriptional regulator
E4630_RS01580	COG2957	Belongs to the agmatine deiminase family
E4630_RS01590	COG0628	permease
E4630_RS01595	COG0494	nUDIX hydrolase
E4630_RS01620	COG0753	catalase activity
E4630_RS01625	COG1247	-acetyltransferase
E4630_RS01645	COG3706	GGDEF domain
E4630_RS01655	COG3842	ATPase activity
E4630_RS01665	COG1175	transmembrane transport
E4630_RS01695	COG0583	DNA-binding transcription factor activity
E4630_RS01705	COG1741	Belongs to the pirin family
E4630_RS01710	COG2259	Doxx family
E4630_RS01715	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4630_RS01720	COG1074	ATP-dependent DNA helicase activity
E4630_RS01725	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4630_RS01745	COG0346	lactoylglutathione lyase activity
E4630_RS01790	COG3706	GGDEF domain
E4630_RS01795	COG4771	TonB-dependent receptor
E4630_RS01800	COG1278	Cold shock
E4630_RS01830	COG2197	response regulator
E4630_RS01835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4630_RS01845	COG3047	cAMP biosynthetic process
E4630_RS01850	COG0840	transmembrane signaling receptor activity
E4630_RS01875	COG3135	benzoate transporter
E4630_RS01880	COG1396	sequence-specific DNA binding
E4630_RS01915	COG2926	Belongs to the UPF0265 family
E4630_RS01925	COG3028	Belongs to the UPF0307 family
E4630_RS01930	COG0312	modulator of DNA gyrase
E4630_RS01935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4630_RS01940	COG5007	Belongs to the BolA IbaG family
E4630_RS01950	COG2854	intermembrane phospholipid transfer
E4630_RS01955	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4630_RS01960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4630_RS01965	COG1127	ABC transporter
E4630_RS01970	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4630_RS01970	COG0517	IMP dehydrogenase activity
E4630_RS01975	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4630_RS01980	COG3117	lipopolysaccharide transmembrane transporter activity
E4630_RS01985	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E4630_RS01990	COG1137	ATPase activity
E4630_RS01995	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4630_RS02005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4630_RS02010	COG1660	Displays ATPase and GTPase activities
E4630_RS02015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4630_RS02020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4630_RS02020	COG3711	transcriptional antiterminator
E4630_RS02035	COG3964	amidohydrolase
E4630_RS02065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4630_RS02070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4630_RS02080	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4630_RS02085	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4630_RS02090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E4630_RS02095	COG0723	plastoquinol--plastocyanin reductase activity
E4630_RS02100	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E4630_RS02105	COG2857	Cytochrome c1
E4630_RS02110	COG0625	glutathione transferase activity
E4630_RS02115	COG2969	positive regulation of protein catabolic process
E4630_RS02120	COG2823	Periplasmic or secreted lipoprotein
E4630_RS02125	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4630_RS02130	COG0792	nuclease activity
E4630_RS02135	COG3107	peptidoglycan biosynthetic process
E4630_RS02140	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4630_RS02150	COG2001	Belongs to the MraZ family
E4630_RS02155	COG0275	rRNA processing
E4630_RS02160	COG3116	cell division
E4630_RS02165	COG0768	penicillin binding
E4630_RS02170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4630_RS02175	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4630_RS02180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4630_RS02185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4630_RS02190	COG0772	Belongs to the SEDS family
E4630_RS02195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4630_RS02200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4630_RS02205	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4630_RS02210	COG0849	cell division
E4630_RS02215	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4630_RS02220	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E4630_RS02230	COG0653	protein targeting
E4630_RS02245	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E4630_RS02250	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E4630_RS02265	COG1459	type II secretion system
E4630_RS02270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4630_RS02300	COG2186	Transcriptional regulator
E4630_RS02310	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4630_RS02315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4630_RS02320	COG3706	GGDEF domain
E4630_RS02330	COG0840	transmembrane signaling receptor activity
E4630_RS02335	COG0840	transmembrane signaling receptor activity
E4630_RS02345	COG1049	propionate catabolic process, 2-methylcitrate cycle
E4630_RS02350	COG2200	EAL domain
E4630_RS02360	COG1280	lysine exporter protein (LysE YggA)
E4630_RS02370	COG0523	cobalamin synthesis protein
E4630_RS02375	COG0477	Major facilitator Superfamily
E4630_RS02390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4630_RS02395	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E4630_RS02435	COG3314	Sporulation integral membrane protein YlbJ
E4630_RS02440	COG0835	chemotaxis
E4630_RS02440	COG0784	Response regulator, receiver
E4630_RS02450	COG1444	tRNA N-acetyltransferase activity
E4630_RS02475	COG1803	Methylglyoxal synthase
E4630_RS02490	COG0252	asparaginase activity
E4630_RS02510	COG1263	PTS System
E4630_RS02510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4630_RS02515	COG0366	Alpha amylase catalytic
E4630_RS02520	COG0110	maltose O-acetyltransferase activity
E4630_RS02525	COG1522	sequence-specific DNA binding
E4630_RS02530	COG5006	permease, DMT superfamily
E4630_RS02540	COG1012	belongs to the aldehyde dehydrogenase family
E4630_RS02545	COG1177	transmembrane transport
E4630_RS02550	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4630_RS02555	COG3842	ATPase activity
E4630_RS02560	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4630_RS02565	COG0583	DNA-binding transcription factor activity
E4630_RS02570	COG1757	Na H antiporter
E4630_RS02610	COG0297	glycogen (starch) synthase activity
E4630_RS02615	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4630_RS02620	COG2813	Specifically methylates the guanine in position
E4630_RS02625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4630_RS02630	COG5001	Diguanylate cyclase
E4630_RS02630	COG2203	Gaf domain
E4630_RS02630	COG4251	negative regulation of phosphorylation
E4630_RS02630	COG3706	GGDEF domain
E4630_RS02640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4630_RS02650	COG2995	paraquat-inducible protein a
E4630_RS02655	COG3008	intermembrane lipid transfer
E4630_RS02655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4630_RS02660	COG3009	Protein conserved in bacteria
E4630_RS02665	COG2885	chlorophyll binding
E4630_RS02665	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4630_RS02675	COG3240	lipase activity
E4630_RS02680	COG3111	PFAM Bacterial OB fold (BOF) protein
E4630_RS02690	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E4630_RS02695	COG1194	a g-specific adenine glycosylase
E4630_RS02705	COG3267	Type II secretory pathway component ExeA
E4630_RS02705	COG3409	Peptidoglycan-binding domain 1 protein
E4630_RS02710	COG0617	tRNA 3'-terminal CCA addition
E4630_RS02725	COG1346	cytolysis
E4630_RS02730	COG1380	Effector of murein hydrolase LrgA
E4630_RS02735	COG0583	DNA-binding transcription factor activity
E4630_RS02765	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4630_RS02770	COG0306	phosphate transporter
E4630_RS02775	COG1392	Phosphate transport regulator
E4630_RS02790	COG1560	Kdo2-lipid A biosynthetic process
E4630_RS02795	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4630_RS02795	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4630_RS02800	COG1538	Outer membrane efflux protein
E4630_RS02805	COG0494	nUDIX hydrolase
E4630_RS02810	COG3151	Protein conserved in bacteria
E4630_RS02820	COG3150	esterase
E4630_RS02825	COG1051	belongs to the nudix hydrolase family
E4630_RS02840	COG1566	PFAM secretion protein HlyD family protein
E4630_RS02845	COG1289	transmembrane transporter activity
E4630_RS02860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4630_RS02895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4630_RS02915	COG0204	Acyl-transferase
E4630_RS02920	COG1842	Phage shock protein A
E4630_RS02935	COG2827	Endonuclease containing a URI domain
E4630_RS02945	COG2962	Rard protein
E4630_RS02950	COG1573	uracil-dna glycosylase
E4630_RS02955	COG0697	spore germination
E4630_RS02960	COG0583	DNA-binding transcription factor activity
E4630_RS02965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4630_RS02970	COG1121	(ABC) transporter
E4630_RS02975	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E4630_RS02995	COG0739	heme binding
E4630_RS03000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4630_RS03005	COG3068	Protein conserved in bacteria
E4630_RS03025	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4630_RS03030	COG1546	Belongs to the CinA family
E4630_RS03035	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4630_RS03045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4630_RS03050	COG0527	aspartate kinase activity
E4630_RS03055	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4630_RS03090	COG1686	Belongs to the peptidase S11 family
E4630_RS03095	COG0586	Pfam SNARE associated Golgi protein
E4630_RS03100	COG1253	flavin adenine dinucleotide binding
E4630_RS03105	COG0525	valine-tRNA ligase activity
E4630_RS03110	COG2927	DNA polymerase III (CHI subunit)
E4630_RS03115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4630_RS03120	COG0795	lipopolysaccharide-transporting ATPase activity
E4630_RS03125	COG0795	lipopolysaccharide-transporting ATPase activity
E4630_RS03140	COG0004	ammonium transporteR
E4630_RS03145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4630_RS03155	COG2165	general secretion pathway protein
E4630_RS03160	COG0084	hydrolase, TatD family'
E4630_RS03165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4630_RS03175	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4630_RS03180	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E4630_RS03185	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E4630_RS03190	COG0813	purine-nucleoside phosphorylase activity
E4630_RS03195	COG5002	protein histidine kinase activity
E4630_RS03195	COG5001	Diguanylate cyclase
E4630_RS03195	COG3447	MASE1 domain protein
E4630_RS03205	COG0560	Phosphoserine phosphatase
E4630_RS03230	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
E4630_RS03240	COG0776	regulation of translation
E4630_RS03255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4630_RS03260	COG0735	belongs to the Fur family
E4630_RS03285	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E4630_RS03290	COG0513	Belongs to the DEAD box helicase family
E4630_RS03295	COG3022	response to hydroperoxide
E4630_RS03310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4630_RS03315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4630_RS03320	COG0762	integral membrane protein
E4630_RS03325	COG1872	DUF167
E4630_RS03340	COG4166	transmembrane transport
E4630_RS03360	COG1024	Enoyl-CoA hydratase
E4630_RS03375	COG4221	oxidoreductase activity
E4630_RS03380	COG0442	prolyl-tRNA aminoacylation
E4630_RS03385	COG0840	transmembrane signaling receptor activity
E4630_RS03390	COG0632	four-way junction helicase activity
E4630_RS03395	COG2255	four-way junction helicase activity
E4630_RS03400	COG1271	oxidase subunit
E4630_RS03405	COG1294	oxidase, subunit
E4630_RS03410	COG4890	Cyd operon protein YbgT
E4630_RS03415	COG3790	cyd operon protein YbgE
E4630_RS03420	COG0824	Thioesterase
E4630_RS03425	COG0811	peptide transport
E4630_RS03440	COG0823	Involved in the tonB-independent uptake of proteins
E4630_RS03445	COG2885	chlorophyll binding
E4630_RS03450	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4630_RS03530	COG0840	transmembrane signaling receptor activity
E4630_RS03535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E4630_RS03540	COG0676	glucose-6-phosphate 1-epimerase activity
E4630_RS03545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4630_RS03550	COG1640	4-alpha-glucanotransferase
E4630_RS03555	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4630_RS03575	COG1051	belongs to the nudix hydrolase family
E4630_RS03580	COG2130	NADP-dependent
E4630_RS03585	COG1764	response to oxidative stress
E4630_RS03590	COG1846	Transcriptional regulator
E4630_RS03625	COG0561	phosphatase activity
E4630_RS03640	COG0733	neurotransmitter:sodium symporter activity
E4630_RS03650	COG0733	neurotransmitter:sodium symporter activity
E4630_RS03675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4630_RS03685	COG1794	racemase activity, acting on amino acids and derivatives
E4630_RS03700	COG2731	YhcH YjgK YiaL family protein
E4630_RS03710	COG0668	transmembrane transport
E4630_RS03720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4630_RS03730	COG3436	PFAM IS66 Orf2 family protein
E4630_RS03735	COG4372	Transposase
E4630_RS03745	COG0789	Transcriptional regulator
E4630_RS03785	COG0583	DNA-binding transcription factor activity
E4630_RS03790	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4630_RS03800	COG0488	(ABC) transporter
E4630_RS03805	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4630_RS03805	COG0517	IMP dehydrogenase activity
E4630_RS03810	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4630_RS03815	COG0330	HflC and HflK could
E4630_RS03820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4630_RS03820	COG1648	precorrin-2 dehydrogenase activity
E4630_RS03825	COG0175	sulfate reduction
E4630_RS03830	COG2895	sulfate adenylyltransferase (ATP) activity
E4630_RS03835	COG0471	metal ion transport
E4630_RS03835	COG3273	potassium ion transport
E4630_RS03840	COG0529	Catalyzes the synthesis of activated sulfate
E4630_RS03870	COG0840	transmembrane signaling receptor activity
E4630_RS03890	COG1136	(ABC) transporter
E4630_RS03905	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E4630_RS03925	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4630_RS03930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4630_RS03935	COG0163	prenyltransferase activity
E4630_RS03950	COG1131	(ABC) transporter
E4630_RS03955	COG0842	Transport permease protein
E4630_RS03960	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4630_RS03965	COG1924	4 iron, 4 sulfur cluster binding
E4630_RS03985	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E4630_RS03990	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E4630_RS03995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4630_RS04005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4630_RS04010	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4630_RS04015	COG1489	DNA binding
E4630_RS04025	COG1643	Atp-dependent helicase
E4630_RS04030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4630_RS04035	COG0346	lactoylglutathione lyase activity
E4630_RS04045	COG2076	Multidrug Resistance protein
E4630_RS04055	COG0784	Response regulator, receiver
E4630_RS04055	COG3437	response regulator, receiver
E4630_RS04065	COG0671	phosphoesterase, PA-phosphatase related
E4630_RS04085	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4630_RS04090	COG0038	chloride channel
E4630_RS04100	COG0316	Belongs to the HesB IscA family
E4630_RS04125	COG1280	lysine exporter protein (LysE YggA)
E4630_RS04130	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E4630_RS04145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4630_RS04175	COG0745	RESPONSE REGULATOR receiver
E4630_RS04180	COG3104	oligopeptide transport
E4630_RS04185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4630_RS04190	COG1555	photosystem II stabilization
E4630_RS04200	COG2350	Protein conserved in bacteria
E4630_RS04205	COG2917	probably involved in intracellular septation
E4630_RS04210	COG0076	glutamate decarboxylase activity
E4630_RS04215	COG1272	protein, Hemolysin III
E4630_RS04220	COG0569	domain protein
E4630_RS04220	COG2985	domain, Protein
E4630_RS04240	COG0784	Response regulator, receiver
E4630_RS04240	COG0835	chemotaxis
E4630_RS04245	COG2755	lipolytic protein G-D-S-L family
E4630_RS04250	COG4181	ATPase activity
E4630_RS04255	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E4630_RS04260	COG1090	epimerase
E4630_RS04270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4630_RS04275	COG4935	Belongs to the peptidase S8 family
E4630_RS04275	COG2234	aminopeptidase activity
E4630_RS04280	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4630_RS04285	COG3171	Protein conserved in bacteria
E4630_RS04290	COG2066	Belongs to the glutaminase family
E4630_RS04295	COG2897	thiosulfate sulfurtransferase activity
E4630_RS04310	COG1132	(ABC) transporter
E4630_RS04345	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E4630_RS04350	COG3300	MHYT domain
E4630_RS04350	COG5001	Diguanylate cyclase
E4630_RS04360	COG2207	Transcriptional regulator
E4630_RS04365	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4630_RS04370	COG3059	membrane
E4630_RS04385	COG4628	conserved protein (DUF2132)
E4630_RS04390	COG0688	phosphatidylethanolamine metabolic process
E4630_RS04395	COG1162	GTPase activity
E4630_RS04400	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E4630_RS04440	COG1278	Cold shock
E4630_RS04450	COG0840	transmembrane signaling receptor activity
E4630_RS04455	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4630_RS04505	COG0848	biopolymer transport protein
E4630_RS04510	COG0811	peptide transport
E4630_RS04515	COG0811	peptide transport
E4630_RS04530	COG4174	ABC transporter (Permease)
E4630_RS04535	COG4239	(ABC) transporter, permease
E4630_RS04545	COG0444	Belongs to the ABC transporter superfamily
E4630_RS04550	COG4608	Belongs to the ABC transporter superfamily
E4630_RS04560	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4630_RS04575	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E4630_RS04580	COG1073	alpha beta
E4630_RS04595	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E4630_RS04625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4630_RS04630	COG2313	pseudouridylate synthase activity
E4630_RS04640	COG1858	cytochrome C peroxidase
E4630_RS04680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4630_RS04705	COG2986	histidine ammonia-lyase
E4630_RS04730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4630_RS04740	COG1028	Short-chain dehydrogenase reductase Sdr
E4630_RS04745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4630_RS04755	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4630_RS04765	COG2966	Psort location CytoplasmicMembrane, score
E4630_RS04770	COG3610	response to peptide
E4630_RS04780	COG4175	Glycine betaine
E4630_RS04785	COG4176	ABC-type proline glycine betaine transport system permease component
E4630_RS04790	COG2113	Glycine betaine
E4630_RS04795	COG0175	sulfate reduction
E4630_RS04800	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4630_RS04805	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E4630_RS04810	COG0384	phenazine biosynthesis protein PhzF
E4630_RS04815	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4630_RS04830	COG0786	glutamate:sodium symporter activity
E4630_RS04835	COG0252	asparaginase activity
E4630_RS04840	COG3139	Protein of unknown function (DUF1315)
E4630_RS04860	COG0616	signal peptide processing
E4630_RS04865	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4630_RS04865	COG1902	pentaerythritol trinitrate reductase activity
E4630_RS04870	COG0778	Nitroreductase
E4630_RS04885	COG2264	protein methyltransferase activity
E4630_RS04890	COG0604	alcohol dehydrogenase
E4630_RS04895	COG0583	DNA-binding transcription factor activity
E4630_RS04900	COG2190	(PTS) system
E4630_RS04900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4630_RS04900	COG1263	PTS System
E4630_RS04905	COG4145	pantothenate transmembrane transporter activity
E4630_RS04915	COG0439	Biotin carboxylase
E4630_RS04920	COG0511	ligase activity, forming carbon-carbon bonds
E4630_RS04925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E4630_RS04930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4630_RS04940	COG3300	MHYT domain
E4630_RS04940	COG5001	Diguanylate cyclase
E4630_RS04960	COG3381	protein complex oligomerization
E4630_RS04970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4630_RS04980	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4630_RS04985	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4630_RS04985	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4630_RS05005	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E4630_RS05010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4630_RS05015	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E4630_RS05020	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4630_RS05025	COG4172	Belongs to the ABC transporter superfamily
E4630_RS05035	COG0601	transmembrane transport
E4630_RS05045	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4630_RS05050	COG0142	geranyltranstransferase activity
E4630_RS05055	COG1722	exodeoxyribonuclease VII activity
E4630_RS05060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4630_RS05065	COG1360	Flagellar Motor Protein
E4630_RS05080	COG1534	Rna-binding protein
E4630_RS05085	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4630_RS05095	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4630_RS05100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4630_RS05105	COG0149	triose-phosphate isomerase activity
E4630_RS05110	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4630_RS05125	COG0779	Required for maturation of 30S ribosomal subunits
E4630_RS05130	COG0195	Participates in both transcription termination and antitermination
E4630_RS05135	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4630_RS05140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4630_RS05145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4630_RS05150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4630_RS05155	COG1185	polyribonucleotide nucleotidyltransferase activity
E4630_RS05160	COG2211	Major facilitator Superfamily
E4630_RS05170	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E4630_RS05180	COG0114	fumarate hydratase activity
E4630_RS05190	COG1966	Carbon starvation protein
E4630_RS05195	COG3279	Response regulator of the LytR AlgR family
E4630_RS05200	COG3275	phosphorelay sensor kinase activity
E4630_RS05265	COG0312	modulator of DNA gyrase
E4630_RS05270	COG0312	modulator of DNA gyrase
E4630_RS05280	COG4974	Belongs to the 'phage' integrase family
E4630_RS05290	COG1970	mechanosensitive ion channel activity
E4630_RS05295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4630_RS05305	COG0789	Transcriptional regulator
E4630_RS05320	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4630_RS05325	COG3545	Serine hydrolase
E4630_RS05335	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4630_RS05345	COG0321	lipoyl(octanoyl) transferase activity
E4630_RS05350	COG2921	Belongs to the UPF0250 family
E4630_RS05355	COG1686	Belongs to the peptidase S11 family
E4630_RS05360	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4630_RS05365	COG2951	lytic endotransglycosylase activity
E4630_RS05370	COG0772	Belongs to the SEDS family
E4630_RS05375	COG0772	Belongs to the SEDS family
E4630_RS05380	COG0768	penicillin binding
E4630_RS05385	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E4630_RS05390	COG0799	negative regulation of ribosome biogenesis
E4630_RS05395	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E4630_RS05415	COG0495	leucyl-tRNA aminoacylation
E4630_RS05420	COG2888	peptidyl-tyrosine sulfation
E4630_RS05425	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4630_RS05430	COG4535	Mg2 and Co2 transporter CorC
E4630_RS05435	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4630_RS05440	COG1702	phosphate starvation-inducible protein PhoH
E4630_RS05445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4630_RS05450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4630_RS05455	COG1335	isochorismatase
E4630_RS05465	COG3706	GGDEF domain
E4630_RS05480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4630_RS05500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4630_RS05510	COG3647	Membrane
E4630_RS05515	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4630_RS05525	COG0516	GMP reductase activity
E4630_RS05545	COG0642	Histidine kinase
E4630_RS05580	COG4106	trans-aconitate 2-methyltransferase activity
E4630_RS05585	COG3214	Protein conserved in bacteria
E4630_RS05610	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
E4630_RS05615	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4630_RS05620	COG1053	succinate dehydrogenase
E4630_RS05630	COG0584	glycerophosphoryl diester phosphodiesterase
E4630_RS05635	COG1511	domain protein
E4630_RS05635	COG3264	Mechanosensitive ion channel
E4630_RS05645	COG0739	heme binding
E4630_RS05660	COG0583	DNA-binding transcription factor activity
E4630_RS05680	COG0583	DNA-binding transcription factor activity
E4630_RS05685	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4630_RS05715	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4630_RS05720	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4630_RS05730	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E4630_RS05745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4630_RS05755	COG0180	Tryptophanyl-tRNA synthetase
E4630_RS05770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4630_RS05780	COG1012	belongs to the aldehyde dehydrogenase family
E4630_RS05790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4630_RS05800	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4630_RS05800	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4630_RS05800	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4630_RS05800	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4630_RS05810	COG0366	Alpha amylase catalytic
E4630_RS05830	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
E4630_RS05840	COG0490	domain, Protein
E4630_RS05840	COG0471	metal ion transport
E4630_RS05885	COG0012	GTP binding
E4630_RS05890	COG0193	aminoacyl-tRNA hydrolase activity
E4630_RS05895	COG0737	Belongs to the 5'-nucleotidase family
E4630_RS05900	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4630_RS05910	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4630_RS05915	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E4630_RS05920	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4630_RS05925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4630_RS05930	COG2890	protein-(glutamine-N5) methyltransferase activity
E4630_RS05940	COG2912	Transglutaminase-like superfamily
E4630_RS05945	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E4630_RS05950	COG1301	dicarboxylic acid transport
E4630_RS05960	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E4630_RS05975	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4630_RS05980	COG1115	amino acid carrier protein
E4630_RS05995	COG0714	Associated with various cellular activities
E4630_RS06005	COG3104	oligopeptide transport
E4630_RS06010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E4630_RS06015	COG1678	Uncharacterized ACR, COG1678
E4630_RS06025	COG0189	ligase activity
E4630_RS06030	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4630_RS06040	COG3091	SprT-like family
E4630_RS06050	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4630_RS06075	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E4630_RS06080	COG0739	heme binding
E4630_RS06085	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4630_RS06090	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E4630_RS06090	COG3408	Glycogen debranching enzyme
E4630_RS06100	COG1881	PFAM PEBP family protein
E4630_RS06105	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E4630_RS06110	COG0583	DNA-binding transcription factor activity
E4630_RS06120	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4630_RS06130	COG0583	DNA-binding transcription factor activity
E4630_RS06135	COG1028	Short-chain dehydrogenase reductase Sdr
E4630_RS06140	COG0616	signal peptide processing
E4630_RS06145	COG3724	N-succinylarginine dihydrolase activity
E4630_RS06165	COG0840	transmembrane signaling receptor activity
E4630_RS06175	COG2971	BadF BadG BcrA BcrD
E4630_RS06185	COG4608	Belongs to the ABC transporter superfamily
E4630_RS06190	COG0444	Belongs to the ABC transporter superfamily
E4630_RS06195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4630_RS06200	COG0601	transmembrane transport
E4630_RS06205	COG4166	transmembrane transport
E4630_RS06210	COG0784	Response regulator, receiver
E4630_RS06210	COG2205	protein histidine kinase activity
E4630_RS06240	COG3220	belongs to the UPF0276 family
E4630_RS06270	COG1289	transmembrane transporter activity
E4630_RS06280	COG0746	molybdenum cofactor guanylyltransferase activity
E4630_RS06290	COG4662	Binding-protein-dependent transport system inner membrane component
E4630_RS06300	COG2204	response regulator
E4630_RS06305	COG3852	Histidine kinase
E4630_RS06310	COG1910	domain protein
E4630_RS06315	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4630_RS06355	COG3383	formate dehydrogenase (NAD+) activity
E4630_RS06355	COG3383	formate dehydrogenase (NAD+) activity
E4630_RS06360	COG0437	4 iron, 4 sulfur cluster binding
E4630_RS06375	COG0281	malic enzyme
E4630_RS06395	COG2706	6-phosphogluconolactonase activity
E4630_RS06405	COG1196	nuclear chromosome segregation
E4630_RS06405	COG3264	Mechanosensitive ion channel
E4630_RS06410	COG0469	pyruvate kinase activity
E4630_RS06425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4630_RS06425	COG4651	solute:proton antiporter activity
E4630_RS06435	COG2974	May be involved in recombination
E4630_RS06445	COG0420	3'-5' exonuclease activity
E4630_RS06455	COG3038	cytochrome b561
E4630_RS06470	COG2190	(PTS) system
E4630_RS06480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4630_RS06485	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4630_RS06490	COG0542	response to heat
E4630_RS06505	COG2770	Histidine kinase
E4630_RS06505	COG3437	response regulator, receiver
E4630_RS06510	COG1720	tRNA m6t6A37 methyltransferase activity
E4630_RS06530	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4630_RS06535	COG4988	ABC transporter
E4630_RS06550	COG0745	RESPONSE REGULATOR receiver
E4630_RS06560	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4630_RS06575	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E4630_RS06580	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4630_RS06595	COG0083	homoserine kinase activity
E4630_RS06600	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4630_RS06605	COG4319	ketosteroid isomerase
E4630_RS06620	COG0488	(ABC) transporter
E4630_RS06635	COG0813	purine-nucleoside phosphorylase activity
E4630_RS06650	COG2205	protein histidine kinase activity
E4630_RS06650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4630_RS06655	COG3384	dioxygenase
E4630_RS06665	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4630_RS06675	COG0531	amino acid
E4630_RS06680	COG0531	amino acid
E4630_RS06695	COG1396	sequence-specific DNA binding
E4630_RS06695	COG1917	Cupin 2, conserved barrel domain protein
E4630_RS06700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4630_RS06715	COG3152	Membrane
E4630_RS06735	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4630_RS06740	COG2375	cellular response to nickel ion
E4630_RS06750	COG1136	(ABC) transporter
E4630_RS06750	COG0577	efflux transmembrane transporter activity
E4630_RS06755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4630_RS06765	COG1227	inorganic diphosphatase activity
E4630_RS06770	COG0497	DNA recombination
E4630_RS06775	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4630_RS06780	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4630_RS06785	COG0443	Heat shock 70 kDa protein
E4630_RS06790	COG0484	heat shock protein binding
E4630_RS06820	COG1285	pathogenesis
E4630_RS06835	COG0640	Transcriptional regulator
E4630_RS06865	COG0095	Lipoate-protein ligase
E4630_RS06885	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4630_RS06890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4630_RS06910	COG0708	Exodeoxyribonuclease III
E4630_RS06970	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4630_RS06975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4630_RS06980	COG1845	cytochrome c oxidase, subunit III
E4630_RS06985	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4630_RS06990	COG0109	protoheme IX farnesyltransferase activity
E4630_RS06995	COG2814	Major facilitator Superfamily
E4630_RS07005	COG2198	Histidine kinase
E4630_RS07005	COG0784	Response regulator, receiver
E4630_RS07005	COG2205	protein histidine kinase activity
E4630_RS07010	COG1879	ABC-type sugar transport system periplasmic component
E4630_RS07020	COG0745	RESPONSE REGULATOR receiver
E4630_RS07025	COG3005	denitrification pathway
E4630_RS07035	COG3381	protein complex oligomerization
E4630_RS07075	COG2003	Belongs to the UPF0758 family
E4630_RS07115	COG0583	DNA-binding transcription factor activity
E4630_RS07130	COG0549	Belongs to the carbamate kinase family
E4630_RS07135	COG1304	FMN binding
E4630_RS07140	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4630_RS07145	COG1335	isochorismatase
E4630_RS07160	COG3311	Transcriptional regulator
E4630_RS07185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4630_RS07215	COG0549	Belongs to the carbamate kinase family
E4630_RS07225	COG1304	FMN binding
E4630_RS07230	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4630_RS07240	COG0666	response to abiotic stimulus
E4630_RS07245	COG0583	DNA-binding transcription factor activity
E4630_RS07285	COG2351	hydroxyisourate hydrolase activity
E4630_RS07310	COG0019	diaminopimelate decarboxylase activity
E4630_RS07315	COG4264	IucA IucC family
E4630_RS07340	COG4772	TonB-dependent receptor
E4630_RS07345	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E4630_RS07350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4630_RS07355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4630_RS07360	COG1120	ATPase activity
E4630_RS07405	COG4792	protein secretion
E4630_RS07410	COG4791	protein targeting
E4630_RS07415	COG4794	Type iii secretion
E4630_RS07420	COG4790	Type iii secretion
E4630_RS07495	COG0457	Tetratricopeptide repeat
E4630_RS07585	COG1317	bacterial-type flagellum organization
E4630_RS07615	COG3436	PFAM IS66 Orf2 family protein
E4630_RS07625	COG0159	tryptophan synthase activity
E4630_RS07630	COG0133	tryptophan synthase activity
E4630_RS07635	COG0135	phosphoribosylanthranilate isomerase activity
E4630_RS07635	COG0134	indole-3-glycerol-phosphate synthase activity
E4630_RS07640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4630_RS07645	COG0512	Glutamine amidotransferase of anthranilate synthase
E4630_RS07645	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4630_RS07650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4630_RS07660	COG0009	L-threonylcarbamoyladenylate synthase
E4630_RS07670	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4630_RS07680	COG1946	Acyl-CoA thioesterase
E4630_RS07695	COG1309	transcriptional regulator
E4630_RS07700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4630_RS07705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4630_RS07720	COG1091	dTDP-4-dehydrorhamnose reductase activity
E4630_RS07750	COG3754	Rhamnan synthesis protein F
E4630_RS07755	COG1215	transferase activity, transferring glycosyl groups
E4630_RS07770	COG2895	sulfate adenylyltransferase (ATP) activity
E4630_RS07775	COG3273	potassium ion transport
E4630_RS07775	COG0471	metal ion transport
E4630_RS07780	COG0529	Catalyzes the synthesis of activated sulfate
E4630_RS07795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4630_RS07865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4630_RS07890	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4630_RS07900	COG3132	Protein of unknown function, DUF480
E4630_RS07940	COG1278	Cold shock
E4630_RS07965	COG4166	transmembrane transport
E4630_RS07970	COG0697	spore germination
E4630_RS07975	COG1349	DNA-binding transcription factor activity
E4630_RS07980	COG1882	Formate acetyltransferase
E4630_RS07985	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4630_RS07990	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4630_RS08020	COG0622	Phosphoesterase
E4630_RS08035	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E4630_RS08040	COG0835	chemotaxis
E4630_RS08040	COG0784	Response regulator, receiver
E4630_RS08045	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4630_RS08050	COG1815	bacterial-type flagellum-dependent cell motility
E4630_RS08070	COG4787	bacterial-type flagellum-dependent cell motility
E4630_RS08080	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E4630_RS08085	COG1706	bacterial-type flagellum-dependent cell motility
E4630_RS08090	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4630_RS08090	COG1705	Flagellar rod assembly protein muramidase FlgJ
E4630_RS08105	COG2239	Acts as a magnesium transporter
E4630_RS08115	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4630_RS08120	COG2716	regulation of RNA biosynthetic process
E4630_RS08145	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4630_RS08150	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4630_RS08155	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4630_RS08160	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4630_RS08180	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4630_RS08190	COG0590	tRNA wobble adenosine to inosine editing
E4630_RS08195	COG0573	inorganic phosphate transmembrane transporter activity
E4630_RS08200	COG0581	inorganic phosphate transmembrane transporter activity
E4630_RS08205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4630_RS08210	COG0704	Plays a role in the regulation of phosphate uptake
E4630_RS08215	COG1253	flavin adenine dinucleotide binding
E4630_RS08230	COG0531	amino acid
E4630_RS08245	COG1126	abc transporter atp-binding protein
E4630_RS08250	COG0765	amino acid transport
E4630_RS08255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4630_RS08265	COG2271	Major facilitator Superfamily
E4630_RS08280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4630_RS08305	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E4630_RS08310	COG0477	Major facilitator Superfamily
E4630_RS08315	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4630_RS08325	COG1199	ATP-dependent helicase activity
E4630_RS08340	COG1448	Aminotransferase
E4630_RS08345	COG0433	COG0433 Predicted ATPase
E4630_RS08360	COG0658	competence protein
E4630_RS08360	COG2333	competence protein COMEC
E4630_RS08365	COG1132	(ABC) transporter
E4630_RS08370	COG1663	tetraacyldisaccharide 4'-kinase activity
E4630_RS08375	COG2835	tetraacyldisaccharide 4'-kinase activity
E4630_RS08380	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E4630_RS08385	COG2197	response regulator
E4630_RS08390	COG0322	excinuclease ABC activity
E4630_RS08415	COG0582	viral genome integration into host DNA
E4630_RS08495	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E4630_RS08500	COG0437	4 iron, 4 sulfur cluster binding
E4630_RS08505	COG3301	Polysulphide reductase, NrfD
E4630_RS08510	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4630_RS08520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4630_RS08530	COG1196	nuclear chromosome segregation
E4630_RS08540	COG2199	diguanylate cyclase activity
E4630_RS08540	COG2203	Gaf domain
E4630_RS08570	COG2119	membrane
E4630_RS08575	COG0023	Translation Initiation Factor
E4630_RS08600	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4630_RS08615	COG2205	protein histidine kinase activity
E4630_RS08615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4630_RS08625	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
E4630_RS08635	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4630_RS08640	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4630_RS08645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4630_RS08650	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4630_RS08655	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4630_RS08660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4630_RS08670	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E4630_RS08675	COG0505	Belongs to the CarA family
E4630_RS08680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4630_RS08685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4630_RS08695	COG2131	deaminase
E4630_RS08715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4630_RS08720	COG0513	Belongs to the DEAD box helicase family
E4630_RS08730	COG4104	PAAR repeat-containing protein
E4630_RS08745	COG0789	Transcriptional regulator
E4630_RS08760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4630_RS08765	COG0765	amino acid transport
E4630_RS08775	COG0493	'glutamate synthase
E4630_RS08780	COG0067	glutamate synthase
E4630_RS08780	COG0069	glutamate synthase activity
E4630_RS08780	COG0070	glutamate synthase
E4630_RS08785	COG1242	4 iron, 4 sulfur cluster binding
E4630_RS08850	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E4630_RS08855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4630_RS08855	COG0574	Belongs to the PEP-utilizing enzyme family
E4630_RS08885	COG1464	Belongs to the NlpA lipoprotein family
E4630_RS08890	COG0671	phosphoesterase, PA-phosphatase related
E4630_RS08895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4630_RS08900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4630_RS08910	COG0101	tRNA pseudouridine synthase activity
E4630_RS08915	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4630_RS08920	COG0285	dihydrofolate synthase activity
E4630_RS08925	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E4630_RS08930	COG2920	part of a sulfur-relay system
E4630_RS08935	COG1289	transmembrane transporter activity
E4630_RS08940	COG0670	Belongs to the BI1 family
E4630_RS08960	COG2194	sulfuric ester hydrolase activity
E4630_RS08970	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E4630_RS08970	COG0392	lysyltransferase activity
E4630_RS08980	COG0840	transmembrane signaling receptor activity
E4630_RS08985	COG5001	Diguanylate cyclase
E4630_RS08990	COG0564	pseudouridine synthase activity
E4630_RS09005	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E4630_RS09015	COG0625	glutathione transferase activity
E4630_RS09020	COG0625	glutathione transferase activity
E4630_RS09030	COG0367	asparagine synthase
E4630_RS09040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4630_RS09040	COG4651	solute:proton antiporter activity
E4630_RS09045	COG0647	UMP catabolic process
E4630_RS09050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4630_RS09055	COG1902	pentaerythritol trinitrate reductase activity
E4630_RS09060	COG1253	flavin adenine dinucleotide binding
E4630_RS09070	COG0277	FAD linked oxidase domain protein
E4630_RS09070	COG0247	lactate metabolic process
E4630_RS09080	COG2050	protein possibly involved in aromatic compounds catabolism
E4630_RS09090	COG2056	Na+-H+ antiporter family
E4630_RS09095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4630_RS09110	COG0346	lactoylglutathione lyase activity
E4630_RS09115	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4630_RS09120	COG4660	Part of a membrane complex involved in electron transport
E4630_RS09125	COG4659	FMN binding
E4630_RS09130	COG4658	electron transport chain
E4630_RS09140	COG2878	Part of a membrane complex involved in electron transport
E4630_RS09145	COG4657	Part of a membrane complex involved in electron transport
E4630_RS09150	COG0697	spore germination
E4630_RS09170	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4630_RS09175	COG1288	antiporter activity
E4630_RS09180	COG3422	double-strand break repair
E4630_RS09185	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4630_RS09255	COG4974	Belongs to the 'phage' integrase family
E4630_RS09260	COG0436	Aminotransferase
E4630_RS09270	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4630_RS09275	COG2027	D-alanyl-D-alanine carboxypeptidase
E4630_RS09280	COG1061	Type III restriction enzyme res subunit
E4630_RS09285	COG1566	PFAM secretion protein HlyD family protein
E4630_RS09295	COG1966	Carbon starvation protein
E4630_RS09300	COG3279	Response regulator of the LytR AlgR family
E4630_RS09305	COG3275	phosphorelay sensor kinase activity
E4630_RS09310	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4630_RS09310	COG2199	diguanylate cyclase activity
E4630_RS09315	COG1012	belongs to the aldehyde dehydrogenase family
E4630_RS09315	COG1454	alcohol dehydrogenase
E4630_RS09325	COG2095	MarC family integral membrane protein
E4630_RS09335	COG0601	transmembrane transport
E4630_RS09340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4630_RS09360	COG0861	Integral membrane protein TerC family
E4630_RS09365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4630_RS09375	COG1301	dicarboxylic acid transport
E4630_RS09395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4630_RS09410	COG0537	adenosine 5'-monophosphoramidase activity
E4630_RS09445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4630_RS09450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4630_RS09460	COG2354	Protein conserved in bacteria
E4630_RS09475	COG2233	PERMEase
E4630_RS09480	COG3150	esterase
E4630_RS09485	COG1252	NADH dehydrogenase
E4630_RS09505	COG0393	Putative heavy-metal-binding
E4630_RS09515	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4630_RS09515	COG1648	precorrin-2 dehydrogenase activity
E4630_RS09535	COG4667	esterase of the alpha-beta hydrolase superfamily
E4630_RS09540	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4630_RS09545	COG1368	sulfuric ester hydrolase activity
E4630_RS09555	COG0527	aspartate kinase activity
E4630_RS09560	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4630_RS09560	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4630_RS09565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4630_RS09590	COG0596	Alpha beta hydrolase
E4630_RS09595	COG0346	lactoylglutathione lyase activity
E4630_RS09605	COG0583	DNA-binding transcription factor activity
E4630_RS09610	COG1620	l-lactate permease
E4630_RS09615	COG0247	lactate metabolic process
E4630_RS09620	COG1139	Iron-sulfur cluster binding protein
E4630_RS09660	COG0577	efflux transmembrane transporter activity
E4630_RS09665	COG1136	(ABC) transporter
E4630_RS09675	COG2814	Major facilitator Superfamily
E4630_RS09695	COG0672	)-iron permease
E4630_RS09725	COG0659	secondary active sulfate transmembrane transporter activity
E4630_RS09750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4630_RS09755	COG0840	transmembrane signaling receptor activity
E4630_RS09765	COG2201	protein-glutamate methylesterase activity
E4630_RS09775	COG0835	chemotaxis
E4630_RS09780	COG3290	protein histidine kinase activity
E4630_RS09780	COG0840	transmembrane signaling receptor activity
E4630_RS09785	COG0643	Histidine kinase
E4630_RS09785	COG2198	Histidine kinase
E4630_RS09795	COG0745	RESPONSE REGULATOR receiver
E4630_RS09800	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E4630_RS09805	COG0437	4 iron, 4 sulfur cluster binding
E4630_RS09810	COG5557	Pfam Polysulphide reductase, NrfD
E4630_RS09815	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E4630_RS09820	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4630_RS09825	COG1773	rubredoxin
E4630_RS09835	COG0601	transmembrane transport
E4630_RS09840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4630_RS09850	COG3842	ATPase activity
E4630_RS09855	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4630_RS09860	COG0375	protein maturation
E4630_RS09865	COG0309	Hydrogenase expression formation protein (HypE)
E4630_RS09875	COG0298	carbon dioxide binding
E4630_RS09880	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E4630_RS09890	COG1921	L-seryl-tRNASec selenium transferase activity
E4630_RS09895	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4630_RS09905	COG3260	NADH ubiquinone oxidoreductase 20
E4630_RS09910	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4630_RS09915	COG3261	NADH dehydrogenase
E4630_RS09915	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E4630_RS09920	COG0650	Formate hydrogenlyase subunit 4
E4630_RS09925	COG0651	ATP synthesis coupled electron transport
E4630_RS09930	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4630_RS09935	COG3158	transport of potassium into the cell
E4630_RS09945	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4630_RS09970	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4630_RS09980	COG0326	Molecular chaperone. Has ATPase activity
E4630_RS09990	COG0563	adenylate kinase activity
E4630_RS09995	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E4630_RS10005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4630_RS10020	COG5001	Diguanylate cyclase
E4630_RS10020	COG3300	MHYT domain
E4630_RS10025	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4630_RS10045	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4630_RS10050	COG3433	isochorismatase activity
E4630_RS10050	COG1535	isochorismatase
E4630_RS10055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4630_RS10060	COG1028	Short-chain dehydrogenase reductase Sdr
E4630_RS10070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4630_RS10080	COG1051	belongs to the nudix hydrolase family
E4630_RS10085	COG3088	subunit of a heme lyase
E4630_RS10085	COG4235	cytochrome complex assembly
E4630_RS10090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4630_RS10095	COG1138	Cytochrome C-type biogenesis protein
E4630_RS10100	COG3301	Polysulphide reductase, NrfD
E4630_RS10105	COG0437	4 iron, 4 sulfur cluster binding
E4630_RS10110	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E4630_RS10125	COG0247	lactate metabolic process
E4630_RS10130	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
E4630_RS10135	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4630_RS10140	COG3012	SEC-C Motif Domain Protein
E4630_RS10145	COG0840	transmembrane signaling receptor activity
E4630_RS10150	COG1846	Transcriptional regulator
E4630_RS10150	COG1940	carbohydrate kinase activity
E4630_RS10155	COG3290	protein histidine kinase activity
E4630_RS10160	COG4565	transcriptional regulatory protein
E4630_RS10180	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4630_RS10185	COG0569	domain protein
E4630_RS10185	COG2985	domain, Protein
E4630_RS10200	COG0556	nucleotide-excision repair
E4630_RS10210	COG0586	Pfam SNARE associated Golgi protein
E4630_RS10215	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E4630_RS10220	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4630_RS10225	COG2186	Transcriptional regulator
E4630_RS10230	COG2719	SpoVR family
E4630_RS10240	COG2766	serine protein kinase
E4630_RS10245	COG0514	ATP-dependent DNA helicase (RecQ)
E4630_RS10250	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4630_RS10255	COG0814	amino acid
E4630_RS10290	COG0058	SHG alpha-glucan phosphorylase activity
E4630_RS10295	COG0471	metal ion transport
E4630_RS10300	COG3118	belongs to the thioredoxin family
E4630_RS10310	COG1132	(ABC) transporter
E4630_RS10320	COG1132	(ABC) transporter
E4630_RS10335	COG2501	S4 domain
E4630_RS10345	COG3243	poly(R)-hydroxyalkanoic acid synthase
E4630_RS10365	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E4630_RS10370	COG2329	Antibiotic biosynthesis monooxygenase
E4630_RS10405	COG0456	acetyltransferase
E4630_RS10410	COG0513	Belongs to the DEAD box helicase family
E4630_RS10415	COG0386	Belongs to the glutathione peroxidase family
E4630_RS10430	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4630_RS10440	COG3148	PFAM DTW domain containing protein
E4630_RS10445	COG0730	response to heat
E4630_RS10450	COG0583	DNA-binding transcription factor activity
E4630_RS10465	COG3593	DNA synthesis involved in DNA repair
E4630_RS10520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4630_RS10525	COG1011	Hydrolase
E4630_RS10530	COG1473	amidohydrolase
E4630_RS10535	COG0205	6-phosphofructokinase activity
E4630_RS10545	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4630_RS10550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4630_RS10560	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E4630_RS10565	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E4630_RS10585	COG0242	peptide deformylase activity
E4630_RS10615	COG0384	phenazine biosynthesis protein PhzF
E4630_RS10635	COG2824	Alkylphosphonate utilization operon protein PhnA
E4630_RS10660	COG0588	phosphoglycerate mutase activity
E4630_RS10665	COG3706	GGDEF domain
E4630_RS10675	COG2840	Smr protein MutS2
E4630_RS10680	COG2890	protein-(glutamine-N5) methyltransferase activity
E4630_RS10685	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4630_RS10695	COG0513	Belongs to the DEAD box helicase family
E4630_RS10700	COG5654	RES domain protein
E4630_RS10710	COG0814	amino acid
E4630_RS10715	COG1609	Transcriptional regulator
E4630_RS10720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4630_RS10720	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4630_RS10725	COG1105	Belongs to the carbohydrate kinase PfkB family
E4630_RS10730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4630_RS10730	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E4630_RS10730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4630_RS10735	COG2140	Oxalate decarboxylase
E4630_RS10740	COG1609	Transcriptional regulator
E4630_RS10755	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4630_RS10755	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4630_RS10760	COG3715	PTS system
E4630_RS10765	COG3716	PTS system mannose fructose sorbose family IID component
E4630_RS10770	COG2942	2-epimerase
E4630_RS10775	COG3313	Fe-S protein
E4630_RS10780	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E4630_RS10785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4630_RS10790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4630_RS10795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4630_RS10805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4630_RS10825	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4630_RS10830	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E4630_RS10835	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4630_RS10840	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4630_RS10845	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E4630_RS10850	COG0072	phenylalanine-tRNA ligase activity
E4630_RS10850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4630_RS10855	COG0776	regulation of translation
E4630_RS10885	COG2199	diguanylate cyclase activity
E4630_RS10890	COG1609	Transcriptional regulator
E4630_RS10895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4630_RS10900	COG1879	ABC-type sugar transport system periplasmic component
E4630_RS10905	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4630_RS10910	COG1129	ABC transporter
E4630_RS10915	COG1869	D-ribose catabolic process
E4630_RS10935	COG0037	tRNA processing
E4630_RS10940	COG0589	response to stress
E4630_RS10945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4630_RS10970	COG2010	Cytochrome c
E4630_RS10985	COG3278	Belongs to the heme-copper respiratory oxidase family
E4630_RS10995	COG1956	GAF domain-containing protein
E4630_RS11000	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E4630_RS11010	COG0308	aminopeptidase N
E4630_RS11020	COG2902	Dehydrogenase
E4630_RS11025	COG0167	dihydroorotate dehydrogenase activity
E4630_RS11035	COG0116	Belongs to the methyltransferase superfamily
E4630_RS11035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4630_RS11045	COG0488	(ABC) transporter
E4630_RS11060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4630_RS11065	COG1067	ATP-dependent peptidase activity
E4630_RS11075	COG3141	response to X-ray
E4630_RS11085	COG4221	oxidoreductase activity
E4630_RS11130	COG0372	Belongs to the citrate synthase family
E4630_RS11135	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E4630_RS11145	COG2995	paraquat-inducible protein a
E4630_RS11150	COG3008	intermembrane lipid transfer
E4630_RS11155	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E4630_RS11155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4630_RS11170	COG0084	hydrolase, TatD family'
E4630_RS11175	COG0470	DNA polymerase III
E4630_RS11180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4630_RS11185	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4630_RS11190	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4630_RS11200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4630_RS11205	COG1028	Short-chain dehydrogenase reductase Sdr
E4630_RS11215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4630_RS11220	COG0416	fatty acid biosynthetic process
E4630_RS11225	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4630_RS11230	COG1399	metal-binding, possibly nucleic acid-binding protein
E4630_RS11245	COG2814	Major facilitator Superfamily
E4630_RS11250	COG0424	maF-like protein
E4630_RS11255	COG0546	phosphoglycolate phosphatase activity
E4630_RS11260	COG0564	pseudouridine synthase activity
E4630_RS11265	COG1530	ribonuclease E activity
E4630_RS11270	COG0306	phosphate transporter
E4630_RS11275	COG0717	Belongs to the dCTP deaminase family
E4630_RS11280	COG0572	uridine kinase
E4630_RS11285	COG0489	protein tyrosine kinase activity
E4630_RS11290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4630_RS11290	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4630_RS11295	COG0625	glutathione transferase activity
E4630_RS11300	COG1254	Belongs to the acylphosphatase family
E4630_RS11305	COG0840	transmembrane signaling receptor activity
E4630_RS11310	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4630_RS11325	COG0709	Synthesizes selenophosphate from selenide and ATP
E4630_RS11330	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E4630_RS11335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4630_RS11340	COG3437	response regulator, receiver
E4630_RS11350	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4630_RS11360	COG1643	Atp-dependent helicase
E4630_RS11365	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E4630_RS11365	COG0517	IMP dehydrogenase activity
E4630_RS11365	COG0617	tRNA 3'-terminal CCA addition
E4630_RS11515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4630_RS11520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4630_RS11665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4630_RS11690	COG0582	viral genome integration into host DNA
E4630_RS11695	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4630_RS11705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4630_RS11710	COG2832	Protein of unknown function (DUF454)
E4630_RS11715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4630_RS11735	COG0318	PFAM AMP-dependent synthetase and ligase
E4630_RS11740	COG0596	Alpha beta hydrolase
E4630_RS11740	COG2226	methyltransferase
E4630_RS11740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4630_RS11750	COG1214	PFAM Peptidase M22, glycoprotease
E4630_RS11760	COG1199	ATP-dependent helicase activity
E4630_RS11770	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E4630_RS11775	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E4630_RS11780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4630_RS11785	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4630_RS11785	COG0131	Imidazoleglycerol-phosphate dehydratase
E4630_RS11790	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4630_RS11795	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E4630_RS11800	COG3437	response regulator, receiver
E4630_RS11805	COG2199	diguanylate cyclase activity
E4630_RS11810	COG2205	protein histidine kinase activity
E4630_RS11810	COG2198	Histidine kinase
E4630_RS11810	COG0784	Response regulator, receiver
E4630_RS11815	COG0107	imidazoleglycerol-phosphate synthase activity
E4630_RS11820	COG0140	phosphoribosyl-ATP diphosphatase activity
E4630_RS11820	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E4630_RS11830	COG0318	PFAM AMP-dependent synthetase and ligase
E4630_RS11835	COG1288	antiporter activity
E4630_RS11845	COG3134	Outer membrane lipoprotein
E4630_RS11855	COG2080	2 iron, 2 sulfur cluster binding
E4630_RS11860	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4630_RS11865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4630_RS11870	COG2252	PERMEase
E4630_RS11875	COG0402	S-adenosylhomocysteine deaminase activity
E4630_RS11880	COG2233	PERMEase
E4630_RS11885	COG2080	2 iron, 2 sulfur cluster binding
E4630_RS11885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4630_RS11890	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4630_RS11895	COG0402	S-adenosylhomocysteine deaminase activity
E4630_RS11900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4630_RS11900	COG0493	'glutamate synthase
E4630_RS11905	COG2068	MobA-Related Protein
E4630_RS11910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4630_RS11915	COG3608	succinylglutamate desuccinylase aspartoacylase
E4630_RS11915	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4630_RS11920	COG0697	spore germination
E4630_RS11925	COG0549	Belongs to the carbamate kinase family
E4630_RS11935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4630_RS11940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4630_RS11945	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4630_RS11950	COG3829	transcription factor binding
E4630_RS11970	COG1024	Enoyl-CoA hydratase
E4630_RS11970	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4630_RS11975	COG0183	Belongs to the thiolase family
E4630_RS11980	COG0714	Associated with various cellular activities
E4630_RS12010	COG1595	DNA-templated transcription, initiation
E4630_RS12025	COG2067	long-chain fatty acid transport protein
E4630_RS12030	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E4630_RS12235	COG3123	guanosine phosphorylase activity
E4630_RS12240	COG1760	l-serine dehydratase
E4630_RS12250	COG1760	l-serine dehydratase
E4630_RS12255	COG2951	lytic endotransglycosylase activity
E4630_RS12260	COG3100	YcgL domain-containing protein
E4630_RS12265	COG0850	regulation of cytokinetic process
E4630_RS12270	COG2894	cell division
E4630_RS12275	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E4630_RS12280	COG3099	Belongs to the UPF0263 family
E4630_RS12285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4630_RS12325	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4630_RS12330	COG0697	spore germination
E4630_RS12335	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E4630_RS12340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4630_RS12350	COG0307	riboflavin synthase, alpha
E4630_RS12360	COG0534	Mate efflux family protein
E4630_RS12390	COG0417	DNA replication proofreading
E4630_RS12415	COG1560	Kdo2-lipid A biosynthetic process
E4630_RS12420	COG1560	Kdo2-lipid A biosynthetic process
E4630_RS12430	COG0583	DNA-binding transcription factor activity
E4630_RS12435	COG0673	inositol 2-dehydrogenase activity
E4630_RS12440	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E4630_RS12445	COG0583	DNA-binding transcription factor activity
E4630_RS12455	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4630_RS12465	COG3300	MHYT domain
E4630_RS12465	COG5001	Diguanylate cyclase
E4630_RS12470	COG2723	6-phospho-beta-galactosidase activity
E4630_RS12475	COG0583	DNA-binding transcription factor activity
E4630_RS12480	COG3300	MHYT domain
E4630_RS12480	COG5001	Diguanylate cyclase
E4630_RS12520	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4630_RS12530	COG2003	Belongs to the UPF0758 family
E4630_RS12565	COG0730	response to heat
E4630_RS12575	COG1028	Short-chain dehydrogenase reductase Sdr
E4630_RS12585	COG1024	Enoyl-CoA hydratase
E4630_RS12590	COG1024	Enoyl-CoA hydratase
E4630_RS12595	COG1960	acyl-CoA dehydrogenase activity
E4630_RS12605	COG1960	acyl-CoA dehydrogenase activity
E4630_RS12610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4630_RS12645	COG1584	GPR1 FUN34 yaaH family protein
E4630_RS12660	COG1115	amino acid carrier protein
E4630_RS12695	COG1024	Enoyl-CoA hydratase
E4630_RS12710	COG3162	membrane
E4630_RS12715	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4630_RS12720	COG0488	(ABC) transporter
E4630_RS12725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4630_RS12730	COG0776	regulation of translation
E4630_RS12735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4630_RS12740	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4630_RS12745	COG0740	serine-type endopeptidase activity
E4630_RS12750	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4630_RS12765	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
E4630_RS12770	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4630_RS12775	COG1136	(ABC) transporter
E4630_RS12780	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4630_RS12790	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4630_RS12795	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E4630_RS12800	COG4166	transmembrane transport
E4630_RS12805	COG0697	spore germination
E4630_RS12815	COG2062	phosphohistidine phosphatase, SixA
E4630_RS12855	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4630_RS12855	COG0519	Catalyzes the synthesis of GMP from XMP
E4630_RS12860	COG0517	IMP dehydrogenase activity
E4630_RS12860	COG0516	GMP reductase activity
E4630_RS12870	COG3158	transport of potassium into the cell
E4630_RS12890	COG0697	spore germination
E4630_RS12895	COG1570	exodeoxyribonuclease VII activity
E4630_RS12910	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4630_RS12915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4630_RS12920	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E4630_RS12960	COG4771	TonB-dependent receptor
E4630_RS12965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4630_RS12970	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4630_RS12975	COG1120	ATPase activity
E4630_RS12980	COG2977	Belongs to the P-Pant transferase superfamily
E4630_RS12985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4630_RS12990	COG3033	Beta-eliminating lyase
E4630_RS13000	COG3046	protein related to deoxyribodipyrimidine photolyase
E4630_RS13005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4630_RS13020	COG0517	IMP dehydrogenase activity
E4630_RS13020	COG0516	GMP reductase activity
E4630_RS13030	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E4630_RS13035	COG0583	DNA-binding transcription factor activity
E4630_RS13045	COG1335	isochorismatase
E4630_RS13065	COG4774	siderophore transport
E4630_RS13080	COG0583	DNA-binding transcription factor activity
E4630_RS13085	COG2910	NAD(P)H-binding
E4630_RS13100	COG0612	Peptidase, M16
E4630_RS13105	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4630_RS13115	COG1944	ATP diphosphatase activity
E4630_RS13120	COG2116	formate transmembrane transporter activity
E4630_RS13125	COG1882	Formate acetyltransferase
E4630_RS13130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4630_RS13135	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4630_RS13140	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4630_RS13150	COG1840	ABC-type Fe3 transport system, periplasmic component
E4630_RS13155	COG3842	ATPase activity
E4630_RS13165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4630_RS13170	COG2983	Belongs to the UPF0260 family
E4630_RS13180	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4630_RS13185	COG0045	succinate-CoA ligase (ADP-forming) activity
E4630_RS13190	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4630_RS13195	COG0567	Dehydrogenase, E1 component
E4630_RS13205	COG1053	succinate dehydrogenase
E4630_RS13210	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E4630_RS13235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4630_RS13240	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4630_RS13240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4630_RS13250	COG3069	C4-dicarboxylate transmembrane transporter activity
E4630_RS13265	COG1451	nucleotide metabolic process
E4630_RS13280	COG0254	rRNA binding
E4630_RS13285	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4630_RS13295	COG0583	DNA-binding transcription factor activity
E4630_RS13305	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4630_RS13315	COG1879	ABC-type sugar transport system periplasmic component
E4630_RS13320	COG1069	ribulokinase activity
E4630_RS13330	COG2160	L-arabinose isomerase activity
E4630_RS13365	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4630_RS13375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4630_RS13410	COG0753	catalase activity
E4630_RS13465	COG2925	Exonuclease
E4630_RS13475	COG3345	alpha-galactosidase
E4630_RS13480	COG1380	Effector of murein hydrolase LrgA
E4630_RS13485	COG1346	cytolysis
E4630_RS13490	COG0295	cytidine deaminase activity
E4630_RS13495	COG1022	Amp-dependent synthetase and ligase
E4630_RS13510	COG0861	Integral membrane protein TerC family
E4630_RS13515	COG2885	chlorophyll binding
E4630_RS13520	COG2199	diguanylate cyclase activity
E4630_RS13540	COG2154	pterin-4-alpha-carbinolamine dehydratase
E4630_RS13550	COG3768	UPF0283 membrane protein
E4630_RS13555	COG3106	COG3106 Predicted ATPase
E4630_RS13570	COG1842	Phage shock protein A
E4630_RS13575	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E4630_RS13585	COG4168	peptide transport system, permease
E4630_RS13590	COG4171	peptide transport system, permease
E4630_RS13600	COG4172	Belongs to the ABC transporter superfamily
E4630_RS13610	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4630_RS13615	COG1286	toxin biosynthetic process
E4630_RS13620	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4630_RS13625	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4630_RS13630	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4630_RS13635	COG0531	amino acid
E4630_RS13635	COG1674	ftsk spoiiie
E4630_RS13645	COG0686	Belongs to the AlaDH PNT family
E4630_RS13650	COG0492	ferredoxin-NADP+ reductase activity
E4630_RS13655	COG3706	GGDEF domain
E4630_RS13660	COG3134	Outer membrane lipoprotein
E4630_RS13665	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E4630_RS13670	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E4630_RS13675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4630_RS13680	COG0542	response to heat
E4630_RS13685	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4630_RS13690	COG1278	Cold shock
E4630_RS13695	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4630_RS13765	COG3829	transcription factor binding
E4630_RS13840	COG3501	Rhs element vgr protein
E4630_RS13855	COG0582	viral genome integration into host DNA
E4630_RS13860	COG3718	enzyme involved in inositol metabolism
E4630_RS13870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4630_RS13880	COG2176	DNA-directed DNA polymerase activity
E4630_RS13890	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4630_RS13895	COG0673	inositol 2-dehydrogenase activity
E4630_RS14035	COG4983	Phage plasmid primase, P4 family domain protein
E4630_RS14085	COG2003	Belongs to the UPF0758 family
E4630_RS14125	COG2188	Transcriptional regulator
E4630_RS14130	COG1397	ADP-ribosylglycohydrolase
E4630_RS14140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4630_RS14150	COG1484	DNA-dependent DNA replication
E4630_RS14155	COG3829	transcription factor binding
E4630_RS14185	COG1435	thymidine kinase activity
E4630_RS14190	COG1757	Na H antiporter
E4630_RS14195	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4630_RS14200	COG2096	Adenosyltransferase
E4630_RS14205	COG3530	Putative quorum-sensing-regulated virulence factor
E4630_RS14210	COG0602	queuosine metabolic process
E4630_RS14215	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E4630_RS14235	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E4630_RS14245	COG0776	regulation of translation
E4630_RS14250	COG0539	negative regulation of cytoplasmic translation
E4630_RS14255	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E4630_RS14260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4630_RS14270	COG0583	DNA-binding transcription factor activity
E4630_RS14290	COG0778	Nitroreductase
E4630_RS14295	COG5001	Diguanylate cyclase
E4630_RS14295	COG3300	MHYT domain
E4630_RS14305	COG0583	DNA-binding transcription factor activity
E4630_RS14310	COG3437	response regulator, receiver
E4630_RS14335	COG4989	oxidoreductase activity
E4630_RS14340	COG0724	RNA recognition motif
E4630_RS14360	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4630_RS14385	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4630_RS14390	COG1192	Involved in chromosome partitioning
E4630_RS14400	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4630_RS14405	COG1360	Flagellar Motor Protein
E4630_RS14410	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4630_RS14415	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4630_RS14420	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4630_RS14420	COG0649	NAD binding
E4630_RS14435	COG1034	ATP synthesis coupled electron transport
E4630_RS14440	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E4630_RS14445	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4630_RS14450	COG0839	Belongs to the complex I subunit 6 family
E4630_RS14455	COG0713	ATP synthesis coupled electron transport
E4630_RS14465	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4630_RS14470	COG1007	ATP synthesis coupled electron transport
E4630_RS14485	COG2199	diguanylate cyclase activity
E4630_RS14485	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4630_RS14490	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4630_RS14490	COG0047	phosphoribosylformylglycinamidine synthase activity
E4630_RS14495	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4630_RS14505	COG1645	bacterial-type flagellum-dependent swarming motility
E4630_RS14510	COG1160	GTP binding
E4630_RS14515	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4630_RS14520	COG2976	Protein conserved in bacteria
E4630_RS14525	COG0124	histidyl-tRNA synthetase
E4630_RS14530	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4630_RS14545	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4630_RS14550	COG0105	UTP biosynthetic process
E4630_RS14555	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4630_RS14565	COG0633	Ferredoxin
E4630_RS14570	COG0443	Heat shock 70 kDa protein
E4630_RS14575	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4630_RS14585	COG0822	iron-sulfur transferase activity
E4630_RS14590	COG1104	cysteine desulfurase activity
E4630_RS14610	COG3154	lipid carrier protein
E4630_RS14615	COG0826	peptidase U32
E4630_RS14620	COG0826	peptidase U32
E4630_RS14635	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4630_RS14640	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4630_RS14645	COG1862	Preprotein translocase
E4630_RS14650	COG0343	queuine tRNA-ribosyltransferase activity
E4630_RS14655	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4630_RS14660	COG0517	IMP dehydrogenase activity
E4630_RS14670	COG3634	alkyl hydroperoxide reductase activity
E4630_RS14685	COG1393	Belongs to the ArsC family
E4630_RS14690	COG0798	PFAM Bile acid sodium symporter
E4630_RS14695	COG0640	Transcriptional regulator
E4630_RS14700	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4630_RS14700	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4630_RS14705	COG0509	glycine decarboxylation via glycine cleavage system
E4630_RS14710	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4630_RS14715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4630_RS14720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4630_RS14740	COG2814	Major facilitator Superfamily
E4630_RS14745	COG0625	glutathione transferase activity
E4630_RS14755	COG0483	inositol monophosphate 1-phosphatase activity
E4630_RS14775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4630_RS14815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4630_RS14820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4630_RS14840	COG0301	tRNA thio-modification
E4630_RS14840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4630_RS14850	COG4953	penicillin-binding protein 1C
E4630_RS14855	COG2373	Large extracellular alpha-helical protein
E4630_RS14860	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4630_RS14870	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4630_RS14890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4630_RS14900	COG2431	L-lysine efflux transmembrane transporter activity
E4630_RS14905	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4630_RS14910	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
E4630_RS14925	COG1393	Belongs to the ArsC family
E4630_RS14935	COG4783	chaperone-mediated protein folding
E4630_RS14940	COG0425	Belongs to the sulfur carrier protein TusA family
E4630_RS14965	COG3842	ATPase activity
E4630_RS14970	COG3833	ABC-type maltose transport systems, permease component
E4630_RS14975	COG1175	transmembrane transport
E4630_RS14985	COG3081	Nucleoid-associated protein
E4630_RS14990	COG3082	Protein of unknown function (DUF1414)
E4630_RS14995	COG3083	sulfuric ester hydrolase activity
E4630_RS15000	COG4771	TonB-dependent receptor
E4630_RS15005	COG1770	oligopeptidase
E4630_RS15025	COG4574	serine-type endopeptidase inhibitor activity
E4630_RS15030	COG3085	chromosome segregation
E4630_RS15035	COG0583	DNA-binding transcription factor activity
E4630_RS15040	COG1605	Chorismate mutase
E4630_RS15040	COG0287	Prephenate dehydrogenase
E4630_RS15045	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4630_RS15050	COG0584	glycerophosphoryl diester phosphodiesterase
E4630_RS15060	COG1349	DNA-binding transcription factor activity
E4630_RS15065	COG2271	Major facilitator Superfamily
E4630_RS15070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4630_RS15075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4630_RS15080	COG0583	DNA-binding transcription factor activity
E4630_RS15110	COG0656	L-ascorbic acid biosynthetic process
E4630_RS15115	COG2814	Major facilitator Superfamily
E4630_RS15125	COG1294	oxidase, subunit
E4630_RS15130	COG1271	oxidase subunit
E4630_RS15135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4630_RS15145	COG2979	Protein of unknown function (DUF533)
E4630_RS15170	COG2271	Major facilitator Superfamily
E4630_RS15175	COG0583	DNA-binding transcription factor activity
E4630_RS15185	COG2807	transmembrane transport
E4630_RS15190	COG1187	pseudouridine synthase activity
E4630_RS15210	COG0346	lactoylglutathione lyase activity
E4630_RS15220	COG1061	Type III restriction enzyme res subunit
E4630_RS15230	COG2964	Protein conserved in bacteria
E4630_RS15235	COG3681	Belongs to the UPF0597 family
E4630_RS15245	COG0814	amino acid
E4630_RS15265	COG1166	arginine decarboxylase activity
E4630_RS15285	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4630_RS15315	COG0583	DNA-binding transcription factor activity
E4630_RS15325	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4630_RS15335	COG0840	transmembrane signaling receptor activity
E4630_RS15340	COG0302	gtp cyclohydrolase
E4630_RS15350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4630_RS15355	COG2267	carboxylic ester hydrolase activity
E4630_RS15360	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E4630_RS15375	COG0314	molybdopterin synthase activity
E4630_RS15380	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E4630_RS15385	COG0315	cyclic pyranopterin monophosphate synthase activity
E4630_RS15390	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4630_RS15395	COG3005	denitrification pathway
E4630_RS15405	COG0348	domain, Protein
E4630_RS15410	COG0437	4 iron, 4 sulfur cluster binding
E4630_RS15415	COG0243	molybdopterin cofactor binding
E4630_RS15425	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4630_RS15425	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4630_RS15430	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4630_RS15435	COG3850	Histidine kinase
E4630_RS15440	COG2197	response regulator
E4630_RS15470	COG0121	glutamine amidotransferase
E4630_RS15475	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4630_RS15480	COG1960	acyl-CoA dehydrogenase activity
E4630_RS15485	COG0784	Response regulator, receiver
E4630_RS15485	COG3437	response regulator, receiver
E4630_RS15500	COG0328	RNA-DNA hybrid ribonuclease activity
E4630_RS15505	COG2226	methyltransferase
E4630_RS15510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4630_RS15515	COG0741	lytic transglycosylase activity
E4630_RS15515	COG1388	LysM domain
E4630_RS15520	COG3021	interspecies interaction between organisms
E4630_RS15530	COG1607	acyl-coa hydrolase
E4630_RS15545	COG0741	lytic transglycosylase activity
E4630_RS15555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4630_RS15575	COG2911	Protein conserved in bacteria
E4630_RS15580	COG0729	surface antigen
E4630_RS15590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4630_RS15595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4630_RS15605	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4630_RS15615	COG4134	Bacterial extracellular solute-binding protein
E4630_RS15625	COG4136	ATPase activity
E4630_RS15630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4630_RS15635	COG2951	lytic endotransglycosylase activity
E4630_RS15650	COG1846	Transcriptional regulator
E4630_RS15660	COG0033	Phosphoglucomutase
E4630_RS15665	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E4630_RS15670	COG0596	Alpha beta hydrolase
E4630_RS15685	COG0716	FMN binding
E4630_RS15695	COG0735	belongs to the Fur family
E4630_RS15700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4630_RS15710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4630_RS15710	COG2190	(PTS) system
E4630_RS15710	COG1263	PTS System
E4630_RS15715	COG0363	glucosamine-6-phosphate deaminase activity
E4630_RS15720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4630_RS15725	COG1846	Transcriptional regulator
E4630_RS15725	COG1940	carbohydrate kinase activity
E4630_RS15730	COG2194	sulfuric ester hydrolase activity
E4630_RS15735	COG0217	transcriptional regulatory protein
E4630_RS15740	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4630_RS15745	COG1801	Protein of unknown function DUF72
E4630_RS15750	COG4106	trans-aconitate 2-methyltransferase activity
E4630_RS15755	COG0500	methyltransferase
E4630_RS15775	COG0450	alkyl hydroperoxide reductase
E4630_RS15780	COG0583	DNA-binding transcription factor activity
E4630_RS15790	COG0791	NLP P60 protein
E4630_RS15805	COG1309	transcriptional regulator
E4630_RS15845	COG0534	Mate efflux family protein
E4630_RS15865	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4630_RS15865	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4630_RS15865	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4630_RS15865	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4630_RS15875	COG0633	Ferredoxin
E4630_RS15875	COG3217	Mosc domain protein beta barrel domain protein
E4630_RS15875	COG3217	Mosc domain protein beta barrel domain protein
E4630_RS15875	COG0633	Ferredoxin
E4630_RS15885	COG0501	Belongs to the peptidase M48B family
E4630_RS15890	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4630_RS15895	COG2226	methyltransferase
E4630_RS15895	COG1073	alpha beta
E4630_RS15900	COG0156	8-amino-7-oxononanoate synthase activity
E4630_RS15905	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4630_RS15925	COG0017	Asparaginyl-tRNA synthetase
E4630_RS15930	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4630_RS15945	COG3069	C4-dicarboxylate transmembrane transporter activity
E4630_RS15955	COG0583	DNA-binding transcription factor activity
E4630_RS15960	COG1393	Belongs to the ArsC family
E4630_RS15965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4630_RS15970	COG1876	peptidase activity
E4630_RS15980	COG3263	regulation of cellular component size
E4630_RS16005	COG1280	lysine exporter protein (LysE YggA)
E4630_RS16045	COG1454	alcohol dehydrogenase
E4630_RS16050	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4630_RS16055	COG0702	epimerase
E4630_RS16060	COG2914	Belongs to the UPF0125 (RnfH) family
E4630_RS16065	COG2867	negative regulation of translational initiation
E4630_RS16070	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4630_RS16080	COG3561	AntA/AntB antirepressor
E4630_RS16315	COG3646	Phage regulatory protein
E4630_RS16315	COG3645	SOS response
E4630_RS16340	COG3646	Phage regulatory protein
E4630_RS16355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4630_RS16395	COG2974	May be involved in recombination
E4630_RS16455	COG1715	Restriction endonuclease
E4630_RS16460	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E4630_RS16475	COG3171	Protein conserved in bacteria
E4630_RS16485	COG0583	DNA-binding transcription factor activity
E4630_RS16490	COG2610	gluconate transmembrane transporter activity
E4630_RS16495	COG3048	D-serine ammonia-lyase activity
E4630_RS16505	COG0538	isocitrate dehydrogenase activity
E4630_RS16510	COG2207	Transcriptional regulator
E4630_RS16515	COG1482	cell wall glycoprotein biosynthetic process
E4630_RS16530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4630_RS16555	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4630_RS16560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4630_RS16560	COG1263	PTS System
E4630_RS16565	COG1609	Transcriptional regulator
E4630_RS16580	COG0456	acetyltransferase
E4630_RS16600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4630_RS16600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4630_RS16600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4630_RS16610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4630_RS16610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4630_RS16610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4630_RS16620	COG1187	pseudouridine synthase activity
E4630_RS16630	COG0482	sulfurtransferase activity
E4630_RS16635	COG2915	High frequency lysogenization protein hflD homolog
E4630_RS16640	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4630_RS16645	COG2850	peptidyl-arginine hydroxylation
E4630_RS16650	COG3153	acetyltransferase
E4630_RS16660	COG0625	glutathione transferase activity
E4630_RS16665	COG0259	pyridoxamine-phosphate oxidase activity
E4630_RS16680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4630_RS16680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4630_RS16685	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4630_RS16700	COG4235	cytochrome complex assembly
E4630_RS16700	COG3088	subunit of a heme lyase
E4630_RS16705	COG4235	cytochrome complex assembly
E4630_RS16705	COG3088	subunit of a heme lyase
E4630_RS16710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4630_RS16715	COG1138	Cytochrome C-type biogenesis protein
E4630_RS16720	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E4630_RS16725	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4630_RS16730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4630_RS16735	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4630_RS16750	COG0835	chemotaxis
E4630_RS16760	COG1192	Involved in chromosome partitioning
E4630_RS16765	COG1360	Flagellar Motor Protein
E4630_RS16770	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4630_RS16775	COG2201	protein-glutamate methylesterase activity
E4630_RS16780	COG0784	Response regulator, receiver
E4630_RS16780	COG2198	Histidine kinase
E4630_RS16780	COG0643	Histidine kinase
E4630_RS16785	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E4630_RS16810	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4630_RS16820	COG1684	flagellar biosynthetic protein fliR
E4630_RS16875	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4630_RS16885	COG1677	Flagellar hook-basal body complex protein FliE
E4630_RS16900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4630_RS16915	COG2994	toxin metabolic process
E4630_RS16925	COG2274	protein secretion by the type I secretion system
E4630_RS16935	COG2274	protein secretion by the type I secretion system
E4630_RS16955	COG1737	Transcriptional regulator
E4630_RS16960	COG0469	pyruvate kinase activity
E4630_RS16970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4630_RS16975	COG1960	acyl-CoA dehydrogenase activity
E4630_RS16990	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E4630_RS17035	COG0243	molybdopterin cofactor binding
E4630_RS17040	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4630_RS17045	COG0583	DNA-binding transcription factor activity
E4630_RS17080	COG1012	belongs to the aldehyde dehydrogenase family
E4630_RS17080	COG1454	alcohol dehydrogenase
E4630_RS17090	COG1454	alcohol dehydrogenase
E4630_RS17090	COG1012	belongs to the aldehyde dehydrogenase family
E4630_RS17095	COG1882	Formate acetyltransferase
E4630_RS17100	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4630_RS17110	COG4869	propanediol catabolic process
E4630_RS17135	COG1073	alpha beta
E4630_RS17140	COG1506	peptidase
E4630_RS17140	COG0823	Involved in the tonB-independent uptake of proteins
E4630_RS17145	COG0702	epimerase
E4630_RS17190	COG4409	exo-alpha-(2->6)-sialidase activity
E4630_RS17195	COG2731	YhcH YjgK YiaL family protein
E4630_RS17200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4630_RS17210	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
E4630_RS17215	COG1737	Transcriptional regulator
E4630_RS17220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4630_RS17225	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E4630_RS17230	COG1349	DNA-binding transcription factor activity
E4630_RS17235	COG0738	Major facilitator superfamily
E4630_RS17245	COG1070	Carbohydrate kinase
E4630_RS17265	COG4172	Belongs to the ABC transporter superfamily
E4630_RS17270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4630_RS17280	COG0747	negative chemotaxis
E4630_RS17300	COG1376	ErfK ybiS ycfS ynhG family protein
E4630_RS17300	COG1388	LysM domain
E4630_RS17315	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
E4630_RS17320	COG0791	NLP P60 protein
E4630_RS17330	COG3118	belongs to the thioredoxin family
E4630_RS17340	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4630_RS17345	COG0788	formyltetrahydrofolate deformylase activity
E4630_RS17355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4630_RS17375	COG0366	Alpha amylase catalytic
E4630_RS17380	COG1196	nuclear chromosome segregation
E4630_RS17380	COG0739	heme binding
E4630_RS17380	COG0741	lytic transglycosylase activity
E4630_RS17385	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4630_RS17390	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4630_RS17400	COG0673	inositol 2-dehydrogenase activity
E4630_RS17420	COG3152	Membrane
E4630_RS17440	COG1032	radical SAM domain protein
E4630_RS17450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4630_RS17455	COG1566	PFAM secretion protein HlyD family protein
E4630_RS17460	COG2203	Gaf domain
E4630_RS17460	COG2199	diguanylate cyclase activity
E4630_RS17465	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4630_RS17470	COG0733	neurotransmitter:sodium symporter activity
E4630_RS17500	COG0281	malic enzyme
E4630_RS17510	COG0534	Mate efflux family protein
E4630_RS17525	COG2233	PERMEase
E4630_RS17530	COG0095	Lipoate-protein ligase
E4630_RS17535	COG1115	amino acid carrier protein
E4630_RS17540	COG0019	diaminopimelate decarboxylase activity
E4630_RS17550	COG0678	peroxiredoxin activity
E4630_RS17560	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E4630_RS17580	COG1131	(ABC) transporter
E4630_RS17585	COG0545	Peptidyl-prolyl cis-trans isomerase
E4630_RS17595	COG3142	Participates in the control of copper homeostasis
E4630_RS17620	COG5002	protein histidine kinase activity
E4630_RS17625	COG0745	RESPONSE REGULATOR receiver
E4630_RS17630	COG0346	lactoylglutathione lyase activity
E4630_RS17635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4630_RS17640	COG1960	acyl-CoA dehydrogenase activity
E4630_RS17645	COG3284	Transcriptional regulator
E4630_RS17660	COG0697	spore germination
E4630_RS17665	COG4565	transcriptional regulatory protein
E4630_RS17670	COG3290	protein histidine kinase activity
E4630_RS17675	COG0281	malic enzyme
E4630_RS17690	COG1846	Transcriptional regulator
E4630_RS17695	COG1566	PFAM secretion protein HlyD family protein
E4630_RS17725	COG0602	queuosine metabolic process
E4630_RS17730	COG1328	CTP reductase activity
E4630_RS17740	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4630_RS17745	COG3115	cell septum assembly
E4630_RS17750	COG1196	nuclear chromosome segregation
E4630_RS17760	COG2860	membrane
E4630_RS17770	COG3108	Peptidase M15
E4630_RS17775	COG2989	Protein conserved in bacteria
E4630_RS17790	COG0463	Glycosyl transferase, family 2
E4630_RS17805	COG0366	Alpha amylase catalytic
E4630_RS17845	COG3706	GGDEF domain
E4630_RS17855	COG3590	peptidase
E4630_RS17865	COG0488	(ABC) transporter
E4630_RS17875	COG0531	amino acid
E4630_RS17885	COG1234	tRNA 3'-trailer cleavage
E4630_RS17890	COG0814	amino acid
E4630_RS17905	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E4630_RS17910	COG1982	Orn Lys Arg decarboxylase major
E4630_RS17915	COG0531	amino acid
E4630_RS17925	COG3710	Transcriptional regulator
E4630_RS17935	COG0825	malonyl-CoA metabolic process
E4630_RS17945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4630_RS17950	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4630_RS17955	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4630_RS17960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4630_RS17965	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4630_RS17980	COG0750	zinc metalloprotease
E4630_RS17985	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4630_RS17990	COG0575	Belongs to the CDS family
E4630_RS17995	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4630_RS18000	COG0233	cytoplasmic translational termination
E4630_RS18005	COG0528	UMP kinase activity
E4630_RS18010	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4630_RS18015	COG0052	Belongs to the universal ribosomal protein uS2 family
E4630_RS18020	COG0024	Methionine aminopeptidase
E4630_RS18025	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E4630_RS18030	COG2171	N-acyltransferase activity
E4630_RS18040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4630_RS18040	COG1263	PTS System
E4630_RS18050	COG4580	involved in the transport of maltose and maltodextrins
E4630_RS18060	COG0564	pseudouridine synthase activity
E4630_RS18065	COG3098	single-species biofilm formation
E4630_RS18090	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
E4630_RS18100	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4630_RS18100	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4630_RS18115	COG1611	Belongs to the LOG family
E4630_RS18120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4630_RS18125	COG0473	3-isopropylmalate dehydrogenase activity
E4630_RS18135	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E4630_RS18140	COG2363	Small membrane protein
E4630_RS18150	COG0583	DNA-binding transcription factor activity
E4630_RS18155	COG0840	transmembrane signaling receptor activity
E4630_RS18160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4630_RS18175	COG1477	protein flavinylation
E4630_RS18180	COG2871	sodium ion transport
E4630_RS18185	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4630_RS18190	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4630_RS18195	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4630_RS18200	COG1805	sodium ion transport
E4630_RS18205	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4630_RS18210	COG0271	Belongs to the BolA IbaG family
E4630_RS18215	COG2813	Specifically methylates the guanine in position
E4630_RS18225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4630_RS18235	COG2211	Major facilitator Superfamily
E4630_RS18245	COG1666	GTP binding
E4630_RS18250	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4630_RS18255	COG0693	protein deglycase activity
E4630_RS18290	COG4104	PAAR repeat-containing protein
E4630_RS18310	COG2771	luxR family
E4630_RS18330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4630_RS18330	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4630_RS18335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4630_RS18345	COG1151	hydroxylamine reductase activity
E4630_RS18350	COG0783	Belongs to the Dps family
E4630_RS18375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4630_RS18390	COG4221	oxidoreductase activity
E4630_RS18400	COG0415	Belongs to the DNA photolyase family
E4630_RS18405	COG0789	Transcriptional regulator
E4630_RS18410	COG3272	Protein of unknown function (DUF1722)
E4630_RS18440	COG0077	Prephenate dehydratase
E4630_RS18440	COG1605	Chorismate mutase
E4630_RS18470	COG3710	Transcriptional regulator
E4630_RS18485	COG5001	Diguanylate cyclase
E4630_RS18505	COG1388	LysM domain
E4630_RS18505	COG4932	domain protein
E4630_RS18505	COG2373	Large extracellular alpha-helical protein
E4630_RS18515	COG1349	DNA-binding transcription factor activity
E4630_RS18520	COG2084	Dehydrogenase
E4630_RS18530	COG0235	Class ii aldolase
E4630_RS18535	COG3622	Belongs to the hyi family
E4630_RS18540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4630_RS18545	COG2610	gluconate transmembrane transporter activity
E4630_RS18555	COG0840	transmembrane signaling receptor activity
E4630_RS18565	COG0300	oxidoreductase activity
E4630_RS18590	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E4630_RS18615	COG0826	peptidase U32
E4630_RS18620	COG1280	lysine exporter protein (LysE YggA)
E4630_RS18630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4630_RS18635	COG0840	transmembrane signaling receptor activity
E4630_RS18650	COG0643	Histidine kinase
E4630_RS18650	COG2198	Histidine kinase
E4630_RS18660	COG0835	chemotaxis
E4630_RS18665	COG0840	transmembrane signaling receptor activity
E4630_RS18675	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E4630_RS18680	COG2201	protein-glutamate methylesterase activity
E4630_RS18685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4630_RS18715	COG2197	response regulator
E4630_RS18740	COG2203	Gaf domain
E4630_RS18740	COG2200	EAL domain
E4630_RS18740	COG2199	diguanylate cyclase activity
E4630_RS18745	COG0826	peptidase U32
E4630_RS18750	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4630_RS18760	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4630_RS18780	COG2200	EAL domain
E4630_RS18785	COG0737	Belongs to the 5'-nucleotidase family
E4630_RS18805	COG2204	response regulator
E4630_RS18810	COG0545	Peptidyl-prolyl cis-trans isomerase
E4630_RS18825	COG1047	Peptidyl-prolyl cis-trans
E4630_RS18830	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E4630_RS18840	COG0784	Response regulator, receiver
E4630_RS18840	COG0835	chemotaxis
E4630_RS18845	COG0429	hydrolase of the alpha beta-hydrolase fold
E4630_RS18850	COG3706	GGDEF domain
E4630_RS18850	COG2203	Gaf domain
E4630_RS18850	COG5001	Diguanylate cyclase
E4630_RS18850	COG4251	negative regulation of phosphorylation
E4630_RS18855	COG3089	Belongs to the UPF0270 family
E4630_RS18865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4630_RS18870	COG0463	Glycosyl transferase, family 2
E4630_RS18875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4630_RS18875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4630_RS18880	COG0726	polysaccharide deacetylase
E4630_RS18885	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4630_RS18890	COG2076	Multidrug Resistance protein
E4630_RS18895	COG2076	Multidrug Resistance protein
E4630_RS18900	COG3954	Phosphoribulokinase
E4630_RS18915	COG1765	OsmC-like protein
E4630_RS18925	COG2226	methyltransferase
E4630_RS18935	COG3397	chitin binding
E4630_RS18950	COG2202	Pas domain
E4630_RS18950	COG2205	protein histidine kinase activity
E4630_RS18960	COG3655	Transcriptional regulator
E4630_RS18965	COG2814	Major facilitator Superfamily
E4630_RS18975	COG4771	TonB-dependent receptor
E4630_RS18995	COG0748	coenzyme F420 binding
E4630_RS19000	COG3721	Heme iron utilization protein
E4630_RS19010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4630_RS19035	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4630_RS19040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4630_RS19045	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E4630_RS19065	COG0741	lytic transglycosylase activity
E4630_RS19070	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4630_RS19085	COG0488	(ABC) transporter
E4630_RS19095	COG2252	PERMEase
E4630_RS19100	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4630_RS19105	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4630_RS19110	COG3178	'Phosphotransferase
E4630_RS19115	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4630_RS19125	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4630_RS19130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4630_RS19135	COG2967	ApaG domain
E4630_RS19140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4630_RS19150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4630_RS19155	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4630_RS19170	COG0318	PFAM AMP-dependent synthetase and ligase
E4630_RS19175	COG3314	Sporulation integral membrane protein YlbJ
E4630_RS19180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4630_RS19185	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4630_RS19190	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4630_RS19195	COG0142	geranyltranstransferase activity
E4630_RS19200	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E4630_RS19205	COG0330	HflC and HflK could
E4630_RS19210	COG0330	HflC and HflK could
E4630_RS19215	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4630_RS19220	COG1923	regulation of RNA biosynthetic process
E4630_RS19225	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4630_RS19230	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4630_RS19240	COG0802	atpase or kinase
E4630_RS19245	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4630_RS19245	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4630_RS19250	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4630_RS19270	COG2011	ABC-type metal ion transport system permease component
E4630_RS19275	COG1464	Belongs to the NlpA lipoprotein family
E4630_RS19285	COG0840	transmembrane signaling receptor activity
E4630_RS19310	COG0784	Response regulator, receiver
E4630_RS19310	COG2198	Histidine kinase
E4630_RS19310	COG5002	protein histidine kinase activity
E4630_RS19330	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
E4630_RS19345	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4630_RS19350	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E4630_RS19360	COG2716	regulation of RNA biosynthetic process
E4630_RS19365	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4630_RS19370	COG3013	Belongs to the UPF0304 family
E4630_RS19380	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4630_RS19385	COG0280	phosphate acetyltransferase
E4630_RS19385	COG0857	belongs to the CobB CobQ family
E4630_RS19400	COG0028	Belongs to the TPP enzyme family
E4630_RS19415	COG0671	phosphoesterase, PA-phosphatase related
E4630_RS19425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4630_RS19430	COG0473	3-isopropylmalate dehydrogenase activity
E4630_RS19435	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E4630_RS19440	COG0066	3-isopropylmalate dehydratase activity
E4630_RS19455	COG4143	(ABC) transporter
E4630_RS19460	COG1178	ABC-type Fe3 transport system permease component
E4630_RS19465	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E4630_RS19470	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E4630_RS19480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4630_RS19510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4630_RS19515	COG0564	pseudouridine synthase activity
E4630_RS19525	COG5001	Diguanylate cyclase
E4630_RS19525	COG3300	MHYT domain
E4630_RS19535	COG0459	protein refolding
E4630_RS19540	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4630_RS19545	COG0534	Mate efflux family protein
E4630_RS19550	COG3030	protein affecting phage T7 exclusion by the F plasmid
E4630_RS19555	COG1027	Aspartate ammonia-lyase
E4630_RS19560	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4630_RS19570	COG0477	Major facilitator Superfamily
E4630_RS19585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4630_RS19590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4630_RS19600	COG0673	inositol 2-dehydrogenase activity
E4630_RS19610	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4630_RS19615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4630_RS19620	COG3036	rescue of stalled ribosome
E4630_RS19625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E4630_RS19635	COG0138	bifunctional purine biosynthesis protein purh
E4630_RS19640	COG0151	Belongs to the GarS family
E4630_RS19740	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4630_RS19760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4630_RS19765	COG0358	DNA primase activity
E4630_RS19770	COG1610	YqeY-like protein
E4630_RS19775	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4630_RS19780	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4630_RS19795	COG1238	metal cluster binding
E4630_RS19800	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E4630_RS19805	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E4630_RS19810	COG0585	pseudouridine synthase activity
E4630_RS19820	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4630_RS19825	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E4630_RS19830	COG0148	phosphopyruvate hydratase activity
E4630_RS19835	COG0504	CTP synthase activity
E4630_RS19840	COG3956	TIGRFAM MazG family protein
E4630_RS19845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4630_RS19850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4630_RS19860	COG4807	Protein conserved in bacteria
E4630_RS19865	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4630_RS19870	COG1349	DNA-binding transcription factor activity
E4630_RS19880	COG2222	sugar isomerase
E4630_RS19885	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4630_RS19895	COG3716	PTS system mannose fructose sorbose family IID component
E4630_RS19900	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4630_RS19905	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4630_RS19920	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E4630_RS19925	COG1381	Involved in DNA repair and RecF pathway recombination
E4630_RS19935	COG0571	ribonuclease III activity
E4630_RS19940	COG0681	Belongs to the peptidase S26 family
E4630_RS19945	COG0481	GTPase activity
E4630_RS19960	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
E4630_RS19965	COG1595	DNA-templated transcription, initiation
E4630_RS19970	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4630_RS19980	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E4630_RS20020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4630_RS20030	COG0126	phosphoglycerate kinase activity
E4630_RS20035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4630_RS20040	COG1940	carbohydrate kinase activity
E4630_RS20045	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4630_RS20060	COG4991	sh3 domain protein
E4630_RS20065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4630_RS20080	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E4630_RS20105	COG1505	serine-type exopeptidase activity
E4630_RS20110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4630_RS20115	COG0765	amino acid transport
E4630_RS20120	COG0765	amino acid transport
E4630_RS20125	COG1126	abc transporter atp-binding protein
E4630_RS20130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4630_RS20135	COG1136	(ABC) transporter
E4630_RS20135	COG0577	efflux transmembrane transporter activity
E4630_RS20140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4630_RS20145	COG0745	RESPONSE REGULATOR receiver
E4630_RS20150	COG2205	protein histidine kinase activity
E4630_RS20155	COG2816	NAD+ diphosphatase activity
E4630_RS20190	COG2070	2-Nitropropane dioxygenase
E4630_RS20215	COG1858	cytochrome C peroxidase
E4630_RS20220	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
E4630_RS20240	COG0513	Belongs to the DEAD box helicase family
E4630_RS20260	COG0154	amidase activity
E4630_RS20265	COG2957	Belongs to the agmatine deiminase family
E4630_RS20280	COG1902	pentaerythritol trinitrate reductase activity
E4630_RS20330	COG0714	Associated with various cellular activities
E4630_RS20340	COG0456	acetyltransferase
E4630_RS20350	COG1022	Amp-dependent synthetase and ligase
E4630_RS20360	COG2918	glutathione biosynthetic process
E4630_RS20365	COG0612	Peptidase, M16
E4630_RS20370	COG1238	metal cluster binding
E4630_RS20395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4630_RS20400	COG0359	binds to the 23S rRNA
E4630_RS20405	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4630_RS20410	COG0360	Binds together with S18 to 16S ribosomal RNA
E4630_RS20415	COG1914	H( )-stimulated, divalent metal cation uptake system
E4630_RS20435	COG2153	protein acetylation
E4630_RS20445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4630_RS20450	COG0557	exoribonuclease II activity
E4630_RS20455	COG3706	GGDEF domain
E4630_RS20460	COG1854	S-ribosylhomocysteine lyase activity
E4630_RS20475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4630_RS20475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4630_RS20530	COG4970	Tfp pilus assembly protein FimT
E4630_RS20535	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4630_RS20540	COG1047	Peptidyl-prolyl cis-trans
E4630_RS20545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4630_RS20550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4630_RS20555	COG0196	riboflavin kinase activity
E4630_RS20560	COG0728	peptidoglycan biosynthetic process
E4630_RS20565	COG0268	Binds directly to 16S ribosomal RNA
E4630_RS20570	COG0640	Transcriptional regulator
E4630_RS20575	COG0583	DNA-binding transcription factor activity
E4630_RS20585	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4630_RS20590	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E4630_RS20595	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4630_RS20605	COG1051	belongs to the nudix hydrolase family
E4630_RS20610	COG3066	DNA modification
E4630_RS20620	COG0335	large ribosomal subunit rRNA binding
E4630_RS20625	COG0336	Belongs to the RNA methyltransferase TrmD family
E4630_RS20630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4630_RS20635	COG0228	four-way junction DNA binding
E4630_RS20640	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4630_RS20645	COG4137	Cytochrome C assembly protein
E4630_RS20650	COG4536	flavin adenine dinucleotide binding
E4630_RS20660	COG1017	nitric oxide dioxygenase activity
E4630_RS20660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4630_RS20665	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4630_RS20670	COG0039	L-malate dehydrogenase activity
E4630_RS20675	COG4160	amino acid transport
E4630_RS20680	COG4215	(ABC) transporter
E4630_RS20685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4630_RS20690	COG1126	abc transporter atp-binding protein
E4630_RS20695	COG1438	arginine binding
E4630_RS20700	COG2837	iron assimilation
E4630_RS20705	COG3842	ATPase activity
E4630_RS20715	COG1840	ABC-type Fe3 transport system, periplasmic component
E4630_RS20720	COG0347	Belongs to the P(II) protein family
E4630_RS20735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4630_RS20740	COG0583	DNA-binding transcription factor activity
E4630_RS20755	COG1929	Belongs to the glycerate kinase type-1 family
E4630_RS20760	COG2610	gluconate transmembrane transporter activity
E4630_RS20765	COG3835	regulator
E4630_RS20775	COG3112	Uncharacterised protein family (UPF0231)
E4630_RS20790	COG0840	transmembrane signaling receptor activity
E4630_RS20810	COG0513	Belongs to the DEAD box helicase family
E4630_RS20850	COG1448	Aminotransferase
E4630_RS20865	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4630_RS20870	COG1328	CTP reductase activity
E4630_RS20890	COG0793	Belongs to the peptidase S41A family
E4630_RS20890	COG4946	Tricorn protease homolog
E4630_RS20920	COG0840	transmembrane signaling receptor activity
E4630_RS20925	COG3397	chitin binding
E4630_RS20930	COG0583	DNA-binding transcription factor activity
E4630_RS20935	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4630_RS20940	COG4208	sulfate ABC transporter
E4630_RS20945	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4630_RS20955	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4630_RS20960	COG3174	membrane
E4630_RS20965	COG0110	maltose O-acetyltransferase activity
E4630_RS20990	COG0165	Argininosuccinate lyase
E4630_RS20995	COG0137	argininosuccinate synthase activity
E4630_RS21005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4630_RS21010	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E4630_RS21020	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E4630_RS21025	COG3621	Patatin-like phospholipase
E4630_RS21035	COG3436	PFAM IS66 Orf2 family protein
E4630_RS21040	COG4372	Transposase
E4630_RS21045	COG3621	Patatin-like phospholipase
E4630_RS21055	COG0460	homoserine dehydrogenase
E4630_RS21055	COG0527	aspartate kinase activity
E4630_RS21060	COG0626	cystathionine gamma-synthase activity
E4630_RS21070	COG3708	Transcriptional regulator
E4630_RS21070	COG2207	Transcriptional regulator
E4630_RS21075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4630_RS21080	COG0814	amino acid
E4630_RS21085	COG1218	3'(2'),5'-bisphosphate nucleotidase
E4630_RS21090	COG0494	nUDIX hydrolase
E4630_RS21095	COG1011	Hydrolase
E4630_RS21100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4630_RS21115	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E4630_RS21125	COG3156	type II secretion system protein K
E4630_RS21135	COG4795	General secretion pathway protein
E4630_RS21140	COG2165	general secretion pathway protein
E4630_RS21155	COG2165	general secretion pathway protein
E4630_RS21160	COG1459	type II secretion system
E4630_RS21165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4630_RS21175	COG3031	protein transport across the cell outer membrane
E4630_RS21185	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4630_RS21190	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E4630_RS21210	COG0456	acetyltransferase
E4630_RS21215	COG3133	Outer membrane lipoprotein
E4630_RS21230	COG2771	luxR family
E4630_RS21235	COG3916	Acyl-homoserine-lactone synthase
E4630_RS21245	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
E4630_RS21250	COG1309	transcriptional regulator
E4630_RS21260	COG2213	PTS system mannitol-specific
E4630_RS21260	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4630_RS21265	COG0246	Mannitol dehydrogenase
E4630_RS21270	COG3722	fumarate hydratase activity
E4630_RS21275	COG3263	regulation of cellular component size
E4630_RS21300	COG1671	Belongs to the UPF0178 family
E4630_RS21315	COG1988	membrane-bound metal-dependent
E4630_RS21320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4630_RS21325	COG0513	Belongs to the DEAD box helicase family
E4630_RS21350	COG1575	Belongs to the MenA family. Type 1 subfamily
E4630_RS21355	COG1169	isochorismate synthase
E4630_RS21360	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E4630_RS21365	COG0596	Alpha beta hydrolase
E4630_RS21370	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E4630_RS21375	COG1441	menaquinone biosynthetic process
E4630_RS21395	COG3539	Fimbrial protein
E4630_RS21405	COG3188	usher protein
E4630_RS21415	COG3539	Fimbrial protein
E4630_RS21430	COG3291	Pkd domain containing protein
E4630_RS21435	COG2949	membrane
E4630_RS21440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4630_RS21455	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E4630_RS21460	COG5380	lipid catabolic process
E4630_RS21475	COG4533	DNA binding
E4630_RS21485	COG2873	o-acetylhomoserine
E4630_RS21495	COG1979	alcohol dehydrogenase
E4630_RS21515	COG4221	oxidoreductase activity
E4630_RS21535	COG1285	pathogenesis
E4630_RS21555	COG1368	sulfuric ester hydrolase activity
E4630_RS21560	COG1522	sequence-specific DNA binding
E4630_RS21570	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E4630_RS21575	COG1418	mRNA catabolic process
E4630_RS21580	COG1058	Belongs to the CinA family
E4630_RS21580	COG1546	Belongs to the CinA family
E4630_RS21590	COG0842	Transport permease protein
E4630_RS21590	COG1129	ABC transporter
E4630_RS21605	COG0561	phosphatase activity
E4630_RS21610	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4630_RS21630	COG1011	Hydrolase
E4630_RS21645	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E4630_RS21650	COG0019	diaminopimelate decarboxylase activity
E4630_RS21660	COG1965	Belongs to the frataxin family
E4630_RS21665	COG0400	carboxylic ester hydrolase activity
E4630_RS21670	COG3072	Adenylate cyclase
E4630_RS21675	COG0181	hydroxymethylbilane synthase activity
E4630_RS21680	COG1587	Uroporphyrinogen-III synthase
E4630_RS21685	COG2959	enzyme of heme biosynthesis
E4630_RS21700	COG1494	fructose-1,6-bisphosphatase
E4630_RS21740	COG1733	regulation of RNA biosynthetic process
E4630_RS21760	COG3932	Exopolysaccharide synthesis, ExoD
E4630_RS21765	COG0814	amino acid
E4630_RS21785	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
E4630_RS21820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4630_RS21825	COG2022	thiamine diphosphate biosynthetic process
E4630_RS21835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4630_RS21840	COG0352	thiamine-phosphate diphosphorylase activity
E4630_RS21845	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E4630_RS21865	COG0745	RESPONSE REGULATOR receiver
E4630_RS21870	COG0642	Histidine kinase
E4630_RS21880	COG0189	ligase activity
E4630_RS21905	COG1639	'signal transduction protein
E4630_RS21915	COG2321	neutral zinc metallopeptidase
E4630_RS21920	COG3700	Belongs to the class B bacterial acid phosphatase family
E4630_RS21940	COG1366	Belongs to the anti-sigma-factor antagonist family
E4630_RS21945	COG2172	sigma factor antagonist activity
E4630_RS21950	COG0784	Response regulator, receiver
E4630_RS21950	COG5002	protein histidine kinase activity
E4630_RS21950	COG2205	protein histidine kinase activity
E4630_RS21955	COG3437	response regulator, receiver
E4630_RS21965	COG0477	Major facilitator Superfamily
E4630_RS21985	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E4630_RS21990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4630_RS21990	COG1263	PTS System
E4630_RS22015	COG0312	modulator of DNA gyrase
E4630_RS22020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4630_RS22030	COG3164	Protein of unknown function
E4630_RS22035	COG1530	ribonuclease E activity
E4630_RS22040	COG0424	maF-like protein
E4630_RS22045	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E4630_RS22050	COG1792	Involved in formation and maintenance of cell shape
E4630_RS22055	COG1077	Cell shape determining protein MreB Mrl
E4630_RS22080	COG4968	Prepilin-type N-terminal cleavage methylation domain
E4630_RS22090	COG2165	general secretion pathway protein
E4630_RS22100	COG1459	type II secretion system
E4630_RS22105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4630_RS22150	COG2200	EAL domain
E4630_RS22150	COG2199	diguanylate cyclase activity
E4630_RS22155	COG2200	EAL domain
E4630_RS22160	COG0387	Pfam Sodium calcium exchanger
E4630_RS22165	COG2986	histidine ammonia-lyase
E4630_RS22170	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4630_RS22175	COG0010	Belongs to the arginase family
E4630_RS22180	COG1228	amidohydrolase
E4630_RS22185	COG2188	Transcriptional regulator
E4630_RS22190	COG0288	reversible hydration of carbon dioxide
E4630_RS22200	COG2177	Part of the ABC transporter FtsEX involved in
E4630_RS22205	COG2884	Cell division ATP-binding protein ftsE
E4630_RS22210	COG0552	protein localization to endoplasmic reticulum
E4630_RS22215	COG0742	ribosomal rna small subunit methyltransferase
E4630_RS22240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4630_RS22245	COG0741	lytic transglycosylase activity
E4630_RS22255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4630_RS22265	COG2095	MarC family integral membrane protein
E4630_RS22275	COG1301	dicarboxylic acid transport
E4630_RS22300	COG3714	YhhN family
E4630_RS22325	COG1770	oligopeptidase
E4630_RS22340	COG4221	oxidoreductase activity
E4630_RS22345	COG0583	DNA-binding transcription factor activity
E4630_RS22350	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4630_RS22405	COG0203	ribosomal protein L17
E4630_RS22410	COG0202	RNA polymerase activity
E4630_RS22415	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4630_RS22420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4630_RS22425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4630_RS22430	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4630_RS22435	COG0201	protein transport
E4630_RS22440	COG0200	Binds to the 23S rRNA
E4630_RS22445	COG1841	ribosomal large subunit assembly
E4630_RS22450	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4630_RS22455	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4630_RS22460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4630_RS22465	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4630_RS22470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4630_RS22475	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4630_RS22480	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4630_RS22485	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4630_RS22490	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4630_RS22495	COG0255	Belongs to the universal ribosomal protein uL29 family
E4630_RS22500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4630_RS22505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4630_RS22510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4630_RS22515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4630_RS22520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4630_RS22525	COG0089	rRNA binding
E4630_RS22530	COG0088	Forms part of the polypeptide exit tunnel
E4630_RS22535	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4630_RS22540	COG0051	transcription antitermination factor activity, RNA binding
E4630_RS22560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4630_RS22565	COG2183	response to ionizing radiation
E4630_RS22585	COG0596	Alpha beta hydrolase
E4630_RS22590	COG1040	competence protein
E4630_RS22595	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4630_RS22595	COG0316	Belongs to the HesB IscA family
E4630_RS22600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4630_RS22605	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E4630_RS22610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4630_RS22615	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E4630_RS22620	COG4942	peptidase
E4630_RS22630	COG1609	Transcriptional regulator
E4630_RS22635	COG0800	Aldolase
E4630_RS22640	COG0129	dihydroxy-acid dehydratase activity
E4630_RS22645	COG3265	gluconokinase activity
E4630_RS22650	COG2610	gluconate transmembrane transporter activity
E4630_RS22655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4630_RS22660	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4630_RS22670	COG0456	acetyltransferase
E4630_RS22680	COG1490	D-aminoacyl-tRNA deacylase activity
E4630_RS22685	COG1295	ribonuclease BN
E4630_RS22690	COG1295	ribonuclease BN
E4630_RS22695	COG1217	gtp-binding protein TYPA
E4630_RS22700	COG0174	glutamine synthetase
E4630_RS22710	COG3852	Histidine kinase
E4630_RS22715	COG2204	response regulator
E4630_RS22720	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4630_RS22725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4630_RS22735	COG3078	GTPase activator activity
E4630_RS22750	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4630_RS22760	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4630_RS22765	COG0408	coproporphyrinogen oxidase activity
E4630_RS22770	COG0009	L-threonylcarbamoyladenylate synthase
E4630_RS22780	COG0551	DNA topoisomerase type I activity
E4630_RS22785	COG2922	Belongs to the Smg family
E4630_RS22790	COG0758	DNA mediated transformation
E4630_RS22800	COG0242	peptide deformylase activity
E4630_RS22805	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4630_RS22810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4630_RS22810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4630_RS22815	COG0569	domain protein
E4630_RS22820	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4630_RS22825	COG1322	Protein conserved in bacteria
E4630_RS22845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4630_RS22850	COG0686	Belongs to the AlaDH PNT family
E4630_RS22855	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4630_RS22855	COG0519	Catalyzes the synthesis of GMP from XMP
E4630_RS22865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4630_RS22870	COG1396	sequence-specific DNA binding
E4630_RS22875	COG1012	belongs to the aldehyde dehydrogenase family
E4630_RS22885	COG2962	Rard protein
E4630_RS22895	COG1280	lysine exporter protein (LysE YggA)
E4630_RS22910	COG2391	methyltransferase activity
E4630_RS22920	COG1280	lysine exporter protein (LysE YggA)
E4630_RS22970	COG0583	DNA-binding transcription factor activity
E4630_RS22990	COG0210	DNA helicase
E4630_RS22995	COG1744	ABC transporter substrate-binding protein PnrA-like
E4630_RS23000	COG3845	ABC transporter
E4630_RS23005	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4630_RS23010	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4630_RS23015	COG0583	DNA-binding transcription factor activity
E4630_RS23035	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4630_RS23040	COG0385	Bile acid
E4630_RS23045	COG0531	amino acid
E4630_RS23050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4630_RS23055	COG0531	amino acid
E4630_RS23060	COG2731	YhcH YjgK YiaL family protein
E4630_RS23065	COG3250	beta-galactosidase activity
E4630_RS23070	COG1609	Transcriptional regulator
E4630_RS23110	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4630_RS23115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4630_RS23115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4630_RS23125	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E4630_RS23130	COG3074	FtsZ-dependent cytokinesis
E4630_RS23140	COG1045	serine acetyltransferase
E4630_RS23150	COG0745	RESPONSE REGULATOR receiver
E4630_RS23155	COG2205	protein histidine kinase activity
E4630_RS23160	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4630_RS23165	COG0534	Mate efflux family protein
E4630_RS23190	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4630_RS23195	COG2937	Belongs to the GPAT DAPAT family
E4630_RS23200	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E4630_RS23205	COG3161	chorismate lyase activity
E4630_RS23210	COG1580	Controls the rotational direction of flagella during chemotaxis
E4630_RS23230	COG0604	alcohol dehydrogenase
E4630_RS23235	COG1609	Transcriptional regulator
E4630_RS23255	COG1519	Transferase
E4630_RS23260	COG0859	PFAM glycosyl transferase family 9
E4630_RS23265	COG0463	Glycosyl transferase, family 2
E4630_RS23270	COG0859	PFAM glycosyl transferase family 9
E4630_RS23275	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4630_RS23280	COG2990	Protein conserved in bacteria
E4630_RS23285	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4630_RS23295	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4630_RS23300	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4630_RS23305	COG2003	Belongs to the UPF0758 family
E4630_RS23310	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4630_RS23315	COG0756	dUTP diphosphatase activity
E4630_RS23320	COG1309	transcriptional regulator
E4630_RS23325	COG0668	transmembrane transport
E4630_RS23340	COG0166	Belongs to the GPI family
E4630_RS23345	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E4630_RS23350	COG0583	DNA-binding transcription factor activity
E4630_RS23365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4630_RS23365	COG1042	CoA-binding domain protein
E4630_RS23365	COG0045	succinate-CoA ligase (ADP-forming) activity
E4630_RS23390	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E4630_RS23395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4630_RS23400	COG1739	Uncharacterized protein family UPF0029
E4630_RS23405	COG0006	proline dipeptidase activity
E4630_RS23410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4630_RS23415	COG1024	Enoyl-CoA hydratase
E4630_RS23415	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4630_RS23420	COG0183	Belongs to the thiolase family
E4630_RS23445	COG0425	Belongs to the sulfur carrier protein TusA family
E4630_RS23450	COG0251	oxidation-reduction process
E4630_RS23460	COG2885	chlorophyll binding
E4630_RS23470	COG2818	Glycosylase
E4630_RS23475	COG0752	glycyl-tRNA synthetase alpha subunit
E4630_RS23480	COG0751	glycine-tRNA ligase activity
E4630_RS23490	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4630_RS23510	COG0814	amino acid
E4630_RS23515	COG0348	domain, Protein
E4630_RS23525	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4630_RS23530	COG1773	rubredoxin
E4630_RS23530	COG0426	domain, Protein
E4630_RS23535	COG3604	Transcriptional regulator
E4630_RS23540	COG2188	Transcriptional regulator
E4630_RS23555	COG1609	Transcriptional regulator
E4630_RS23595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4630_RS23620	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4630_RS23635	COG3118	belongs to the thioredoxin family
E4630_RS23640	COG0513	Belongs to the DEAD box helicase family
E4630_RS23645	COG0248	Ppx GppA phosphatase
E4630_RS23660	COG0742	ribosomal rna small subunit methyltransferase
E4630_RS23680	COG0084	hydrolase, TatD family'
E4630_RS23685	COG0805	protein transport
E4630_RS23690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4630_RS23700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E4630_RS23705	COG3165	ubiquinone biosynthetic process from chorismate
E4630_RS23715	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E4630_RS23720	COG0402	S-adenosylhomocysteine deaminase activity
E4630_RS23760	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E4630_RS23765	COG0848	biopolymer transport protein
E4630_RS23770	COG0811	peptide transport
E4630_RS23775	COG0811	peptide transport
E4630_RS23785	COG2771	luxR family
E4630_RS23790	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4630_RS23795	COG1349	DNA-binding transcription factor activity
E4630_RS23800	COG0745	RESPONSE REGULATOR receiver
E4630_RS23805	COG2205	protein histidine kinase activity
E4630_RS23815	COG4452	Inner membrane protein CreD
E4630_RS23820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4630_RS23825	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E4630_RS23830	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E4630_RS23835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E4630_RS23840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E4630_RS23845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4630_RS23850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E4630_RS23860	COG0356	it plays a direct role in the translocation of protons across the membrane
E4630_RS23870	COG1475	DNA binding
E4630_RS23875	COG1192	Involved in chromosome partitioning
E4630_RS23880	COG0357	Ribosomal RNA small subunit methyltransferase G
E4630_RS23885	COG0445	tRNA wobble uridine modification
E4630_RS23890	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E4630_RS23895	COG4774	siderophore transport
E4630_RS23900	COG4615	Cyclic peptide transporter
E4630_RS23905	COG1120	ATPase activity
E4630_RS23920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4630_RS23925	COG0706	membrane insertase activity
E4630_RS23930	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4630_RS23935	COG0594	ribonuclease P activity
E4630_RS23940	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4630_RS23945	COG1126	abc transporter atp-binding protein
E4630_RS23980	COG1357	PFAM Pentapeptide repeats (8 copies)
E4630_RS24055	COG3173	Aminoglycoside phosphotransferase
E4630_RS24085	COG3436	PFAM IS66 Orf2 family protein
E4630_RS24090	COG4372	Transposase
E4630_RS24210	COG4974	Belongs to the 'phage' integrase family
E4630_RS24365	COG0616	signal peptide processing
E4630_RS24580	COG1192	Involved in chromosome partitioning
E4630_RS24660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4630_RS24775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4630_RS24800	COG5001	Diguanylate cyclase
E4630_RS24835	COG0714	Associated with various cellular activities
E4630_RS24845	COG0629	single-stranded DNA binding
E4630_RS24895	COG0633	Ferredoxin