locus-tag	class	description
AH4AK4_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AH4AK4_RS00010	COG0592	DNA-directed DNA polymerase activity
AH4AK4_RS00020	COG0187	DNA topoisomerase II activity
AH4AK4_RS00030	COG2378	regulation of single-species biofilm formation
AH4AK4_RS00040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AH4AK4_RS00045	COG0071	Belongs to the small heat shock protein (HSP20) family
AH4AK4_RS00050	COG0071	Belongs to the small heat shock protein (HSP20) family
AH4AK4_RS00055	COG3977	Valine--pyruvate aminotransferase
AH4AK4_RS00070	COG2814	Major facilitator Superfamily
AH4AK4_RS00075	COG0745	RESPONSE REGULATOR receiver
AH4AK4_RS00080	COG2205	protein histidine kinase activity
AH4AK4_RS00100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AH4AK4_RS00105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_RS00105	COG4191	Histidine kinase
AH4AK4_RS00110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AH4AK4_RS00115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AH4AK4_RS00120	COG1309	transcriptional regulator
AH4AK4_RS00150	COG0561	phosphatase activity
AH4AK4_RS00155	COG2267	carboxylic ester hydrolase activity
AH4AK4_RS00165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AH4AK4_RS00170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AH4AK4_RS00175	COG1758	RNA polymerase activity
AH4AK4_RS00180	COG0194	GDP metabolic process
AH4AK4_RS00185	COG0859	PFAM glycosyl transferase family 9
AH4AK4_RS00190	COG3642	lipopolysaccharide core region biosynthetic process
AH4AK4_RS00225	COG0589	response to stress
AH4AK4_RS00230	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AH4AK4_RS00235	COG3706	GGDEF domain
AH4AK4_RS00240	COG1528	Iron-storage protein
AH4AK4_RS00245	COG2081	HI0933 family
AH4AK4_RS00250	COG2223	nitrite transmembrane transporter activity
AH4AK4_RS00270	COG3188	usher protein
AH4AK4_RS00290	COG2205	protein histidine kinase activity
AH4AK4_RS00290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_RS00300	COG3275	phosphorelay sensor kinase activity
AH4AK4_RS00305	COG3279	Response regulator of the LytR AlgR family
AH4AK4_RS00310	COG2223	nitrite transmembrane transporter activity
AH4AK4_RS00315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AH4AK4_RS00320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AH4AK4_RS00325	COG4206	TonB-dependent receptor
AH4AK4_RS00330	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AH4AK4_RS00365	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AH4AK4_RS00370	COG2166	iron-sulfur cluster assembly
AH4AK4_RS00375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AH4AK4_RS00380	COG0210	DNA helicase
AH4AK4_RS00395	COG1063	alcohol dehydrogenase
AH4AK4_RS00410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AH4AK4_RS00455	COG1609	Transcriptional regulator
AH4AK4_RS00460	COG0604	alcohol dehydrogenase
AH4AK4_RS00470	COG1580	Controls the rotational direction of flagella during chemotaxis
AH4AK4_RS00475	COG3161	chorismate lyase activity
AH4AK4_RS00480	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AH4AK4_RS00485	COG2937	Belongs to the GPAT DAPAT family
AH4AK4_RS00490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AH4AK4_RS00505	COG0534	Mate efflux family protein
AH4AK4_RS00510	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AH4AK4_RS00515	COG2205	protein histidine kinase activity
AH4AK4_RS00520	COG0745	RESPONSE REGULATOR receiver
AH4AK4_RS00530	COG1045	serine acetyltransferase
AH4AK4_RS00540	COG3074	FtsZ-dependent cytokinesis
AH4AK4_RS00545	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AH4AK4_RS00550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AH4AK4_RS00550	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AH4AK4_RS00555	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AH4AK4_RS00595	COG1609	Transcriptional regulator
AH4AK4_RS00600	COG3250	beta-galactosidase activity
AH4AK4_RS00605	COG2731	YhcH YjgK YiaL family protein
AH4AK4_RS00610	COG0531	amino acid
AH4AK4_RS00615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AH4AK4_RS00620	COG0531	amino acid
AH4AK4_RS00625	COG0385	Bile acid
AH4AK4_RS00655	COG0583	DNA-binding transcription factor activity
AH4AK4_RS00665	COG1079	Belongs to the binding-protein-dependent transport system permease family
AH4AK4_RS00670	COG4603	Belongs to the binding-protein-dependent transport system permease family
AH4AK4_RS00675	COG3845	ABC transporter
AH4AK4_RS00680	COG1744	ABC transporter substrate-binding protein PnrA-like
AH4AK4_RS00685	COG0210	DNA helicase
AH4AK4_RS00695	COG1943	Transposase
AH4AK4_RS00700	COG0583	DNA-binding transcription factor activity
AH4AK4_RS00710	COG1733	regulation of RNA biosynthetic process
AH4AK4_RS00725	COG2823	Periplasmic or secreted lipoprotein
AH4AK4_RS00740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AH4AK4_RS00775	COG0583	DNA-binding transcription factor activity
AH4AK4_RS00780	COG1280	lysine exporter protein (LysE YggA)
AH4AK4_RS00785	COG2391	methyltransferase activity
AH4AK4_RS00790	COG1280	lysine exporter protein (LysE YggA)
AH4AK4_RS00800	COG2962	Rard protein
AH4AK4_RS00805	COG1012	belongs to the aldehyde dehydrogenase family
AH4AK4_RS00810	COG1396	sequence-specific DNA binding
AH4AK4_RS00815	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AH4AK4_RS00825	COG0519	Catalyzes the synthesis of GMP from XMP
AH4AK4_RS00825	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AH4AK4_RS00835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AH4AK4_RS00855	COG1322	Protein conserved in bacteria
AH4AK4_RS00860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AH4AK4_RS00865	COG0569	domain protein
AH4AK4_RS00870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AH4AK4_RS00870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AH4AK4_RS00875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AH4AK4_RS00880	COG0242	peptide deformylase activity
AH4AK4_RS00890	COG0758	DNA mediated transformation
AH4AK4_RS00895	COG2922	Belongs to the Smg family
AH4AK4_RS00900	COG0551	DNA topoisomerase type I activity
AH4AK4_RS00905	COG0009	L-threonylcarbamoyladenylate synthase
AH4AK4_RS00910	COG0408	coproporphyrinogen oxidase activity
AH4AK4_RS00915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AH4AK4_RS00920	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AH4AK4_RS00930	COG3078	GTPase activator activity
AH4AK4_RS00940	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AH4AK4_RS00945	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AH4AK4_RS00955	COG3852	Histidine kinase
AH4AK4_RS00965	COG0174	glutamine synthetase
AH4AK4_RS00970	COG1217	gtp-binding protein TYPA
AH4AK4_RS00975	COG1295	ribonuclease BN
AH4AK4_RS00980	COG1490	D-aminoacyl-tRNA deacylase activity
AH4AK4_RS00990	COG0456	acetyltransferase
AH4AK4_RS01000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AH4AK4_RS01005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AH4AK4_RS01010	COG2610	gluconate transmembrane transporter activity
AH4AK4_RS01015	COG3265	gluconokinase activity
AH4AK4_RS01020	COG0129	dihydroxy-acid dehydratase activity
AH4AK4_RS01025	COG0800	Aldolase
AH4AK4_RS01040	COG1609	Transcriptional regulator
AH4AK4_RS01050	COG4942	peptidase
AH4AK4_RS01055	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AH4AK4_RS01060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AH4AK4_RS01065	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AH4AK4_RS01070	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AH4AK4_RS01075	COG0316	Belongs to the HesB IscA family
AH4AK4_RS01075	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AH4AK4_RS01080	COG1040	competence protein
AH4AK4_RS01085	COG0596	Alpha beta hydrolase
AH4AK4_RS01100	COG2183	response to ionizing radiation
AH4AK4_RS01105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AH4AK4_RS01115	COG2205	protein histidine kinase activity
AH4AK4_RS01125	COG0051	transcription antitermination factor activity, RNA binding
AH4AK4_RS01130	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AH4AK4_RS01135	COG0088	Forms part of the polypeptide exit tunnel
AH4AK4_RS01140	COG0089	rRNA binding
AH4AK4_RS01150	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AH4AK4_RS01155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AH4AK4_RS01160	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AH4AK4_RS01165	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AH4AK4_RS01170	COG0255	Belongs to the universal ribosomal protein uL29 family
AH4AK4_RS01175	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AH4AK4_RS01180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AH4AK4_RS01185	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AH4AK4_RS01190	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AH4AK4_RS01195	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AH4AK4_RS01200	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AH4AK4_RS01205	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AH4AK4_RS01210	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AH4AK4_RS01215	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AH4AK4_RS01220	COG0200	Binds to the 23S rRNA
AH4AK4_RS01225	COG0201	protein transport
AH4AK4_RS01230	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AH4AK4_RS01235	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AH4AK4_RS01240	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AH4AK4_RS01245	COG0202	RNA polymerase activity
AH4AK4_RS01250	COG0203	ribosomal protein L17
AH4AK4_RS01275	COG2249	NAD(P)H dehydrogenase (quinone) activity
AH4AK4_RS01280	COG0583	DNA-binding transcription factor activity
AH4AK4_RS01285	COG4221	oxidoreductase activity
AH4AK4_RS01300	COG1770	oligopeptidase
AH4AK4_RS01315	COG3714	YhhN family
AH4AK4_RS01340	COG1301	dicarboxylic acid transport
AH4AK4_RS01350	COG2095	MarC family integral membrane protein
AH4AK4_RS01360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AH4AK4_RS01370	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AH4AK4_RS01375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AH4AK4_RS01400	COG0742	ribosomal rna small subunit methyltransferase
AH4AK4_RS01405	COG0552	protein localization to endoplasmic reticulum
AH4AK4_RS01410	COG2884	Cell division ATP-binding protein ftsE
AH4AK4_RS01415	COG2177	Part of the ABC transporter FtsEX involved in
AH4AK4_RS01425	COG0288	reversible hydration of carbon dioxide
AH4AK4_RS01430	COG2188	Transcriptional regulator
AH4AK4_RS01435	COG1228	amidohydrolase
AH4AK4_RS01440	COG0010	Belongs to the arginase family
AH4AK4_RS01445	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AH4AK4_RS01455	COG0387	Pfam Sodium calcium exchanger
AH4AK4_RS01460	COG2200	EAL domain
AH4AK4_RS01510	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AH4AK4_RS01515	COG1459	type II secretion system
AH4AK4_RS01530	COG4969	Belongs to the N-Me-Phe pilin family
AH4AK4_RS01535	COG4968	Prepilin-type N-terminal cleavage methylation domain
AH4AK4_RS01560	COG1077	Cell shape determining protein MreB Mrl
AH4AK4_RS01565	COG1792	Involved in formation and maintenance of cell shape
AH4AK4_RS01570	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AH4AK4_RS01575	COG0424	maF-like protein
AH4AK4_RS01580	COG1530	ribonuclease E activity
AH4AK4_RS01585	COG3164	Protein of unknown function
AH4AK4_RS01590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AH4AK4_RS01595	COG0312	modulator of DNA gyrase
AH4AK4_RS01610	COG0477	Major facilitator Superfamily
AH4AK4_RS01620	COG2321	neutral zinc metallopeptidase
AH4AK4_RS01650	COG0189	ligase activity
AH4AK4_RS01660	COG0745	RESPONSE REGULATOR receiver
AH4AK4_RS01680	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AH4AK4_RS01685	COG0352	thiamine-phosphate diphosphorylase activity
AH4AK4_RS01690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AH4AK4_RS01700	COG2022	thiamine diphosphate biosynthetic process
AH4AK4_RS01705	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AH4AK4_RS01710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AH4AK4_RS01715	COG0110	maltose O-acetyltransferase activity
AH4AK4_RS01735	COG3932	Exopolysaccharide synthesis, ExoD
AH4AK4_RS01770	COG0456	acetyltransferase
AH4AK4_RS01780	COG1494	fructose-1,6-bisphosphatase
AH4AK4_RS01790	COG3071	HemY protein
AH4AK4_RS01795	COG2959	enzyme of heme biosynthesis
AH4AK4_RS01805	COG0181	hydroxymethylbilane synthase activity
AH4AK4_RS01810	COG3072	Adenylate cyclase
AH4AK4_RS01815	COG0400	carboxylic ester hydrolase activity
AH4AK4_RS01820	COG1965	Belongs to the frataxin family
AH4AK4_RS01830	COG0019	diaminopimelate decarboxylase activity
AH4AK4_RS01835	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AH4AK4_RS01850	COG1011	Hydrolase
AH4AK4_RS01860	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AH4AK4_RS01865	COG0561	phosphatase activity
AH4AK4_RS01875	COG1988	membrane-bound metal-dependent
AH4AK4_RS01880	COG1546	Belongs to the CinA family
AH4AK4_RS01880	COG1058	Belongs to the CinA family
AH4AK4_RS01890	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AH4AK4_RS01900	COG1522	sequence-specific DNA binding
AH4AK4_RS01905	COG1368	sulfuric ester hydrolase activity
AH4AK4_RS01920	COG1285	pathogenesis
AH4AK4_RS01940	COG4221	oxidoreductase activity
AH4AK4_RS01955	COG1979	alcohol dehydrogenase
AH4AK4_RS01965	COG2873	o-acetylhomoserine
AH4AK4_RS01985	COG5380	lipid catabolic process
AH4AK4_RS01990	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AH4AK4_RS02000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AH4AK4_RS02005	COG2949	membrane
AH4AK4_RS02010	COG3291	Pkd domain containing protein
AH4AK4_RS02015	COG0318	PFAM AMP-dependent synthetase and ligase
AH4AK4_RS02020	COG1441	menaquinone biosynthetic process
AH4AK4_RS02025	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AH4AK4_RS02030	COG0596	Alpha beta hydrolase
AH4AK4_RS02035	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AH4AK4_RS02040	COG1169	isochorismate synthase
AH4AK4_RS02045	COG1575	Belongs to the MenA family. Type 1 subfamily
AH4AK4_RS02050	COG1966	Carbon starvation protein
AH4AK4_RS02055	COG2879	small protein
AH4AK4_RS02060	COG0523	cobalamin synthesis protein
AH4AK4_RS02085	COG0513	Belongs to the DEAD box helicase family
AH4AK4_RS02090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AH4AK4_RS02110	COG1671	Belongs to the UPF0178 family
AH4AK4_RS02135	COG3722	fumarate hydratase activity
AH4AK4_RS02140	COG0246	Mannitol dehydrogenase
AH4AK4_RS02145	COG2213	PTS system mannitol-specific
AH4AK4_RS02145	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AH4AK4_RS02150	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AH4AK4_RS02165	COG2771	luxR family
AH4AK4_RS02180	COG1560	Kdo2-lipid A biosynthetic process
AH4AK4_RS02185	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AH4AK4_RS02185	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AH4AK4_RS02190	COG1538	Outer membrane efflux protein
AH4AK4_RS02195	COG0494	nUDIX hydrolase
AH4AK4_RS02200	COG3151	Protein conserved in bacteria
AH4AK4_RS02210	COG3150	esterase
AH4AK4_RS02215	COG1051	belongs to the nudix hydrolase family
AH4AK4_RS02230	COG1566	PFAM secretion protein HlyD family protein
AH4AK4_RS02235	COG1289	transmembrane transporter activity
AH4AK4_RS02305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AH4AK4_RS02330	COG0204	Acyl-transferase
AH4AK4_RS02335	COG1842	Phage shock protein A
AH4AK4_RS02350	COG2827	Endonuclease containing a URI domain
AH4AK4_RS02360	COG1573	uracil-dna glycosylase
AH4AK4_RS02370	COG0583	DNA-binding transcription factor activity
AH4AK4_RS02375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AH4AK4_RS02380	COG1121	(ABC) transporter
AH4AK4_RS02385	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AH4AK4_RS02405	COG0739	heme binding
AH4AK4_RS02435	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AH4AK4_RS02445	COG1546	Belongs to the CinA family
AH4AK4_RS02450	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AH4AK4_RS02455	COG2137	regulation of response to DNA damage stimulus
AH4AK4_RS02460	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AH4AK4_RS02465	COG0527	aspartate kinase activity
AH4AK4_RS02470	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AH4AK4_RS02505	COG1686	Belongs to the peptidase S11 family
AH4AK4_RS02510	COG0586	Pfam SNARE associated Golgi protein
AH4AK4_RS02515	COG1253	flavin adenine dinucleotide binding
AH4AK4_RS02520	COG0525	valine-tRNA ligase activity
AH4AK4_RS02525	COG2927	DNA polymerase III (CHI subunit)
AH4AK4_RS02530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AH4AK4_RS02535	COG0795	lipopolysaccharide-transporting ATPase activity
AH4AK4_RS02540	COG0795	lipopolysaccharide-transporting ATPase activity
AH4AK4_RS02555	COG0004	ammonium transporteR
AH4AK4_RS02560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AH4AK4_RS02570	COG2165	general secretion pathway protein
AH4AK4_RS02575	COG0084	hydrolase, TatD family'
AH4AK4_RS02580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AH4AK4_RS02590	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AH4AK4_RS02595	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AH4AK4_RS02600	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AH4AK4_RS02605	COG0813	purine-nucleoside phosphorylase activity
AH4AK4_RS02630	COG0560	Phosphoserine phosphatase
AH4AK4_RS02645	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AH4AK4_RS02655	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AH4AK4_RS02660	COG0776	regulation of translation
AH4AK4_RS02670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AH4AK4_RS02675	COG0735	belongs to the Fur family
AH4AK4_RS02695	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AH4AK4_RS02700	COG0513	Belongs to the DEAD box helicase family
AH4AK4_RS02705	COG3022	response to hydroperoxide
AH4AK4_RS02720	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AH4AK4_RS02725	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AH4AK4_RS02730	COG0762	integral membrane protein
AH4AK4_RS02735	COG1872	DUF167
AH4AK4_RS02755	COG3112	Uncharacterised protein family (UPF0231)
AH4AK4_RS02760	COG3835	regulator
AH4AK4_RS02765	COG2610	gluconate transmembrane transporter activity
AH4AK4_RS02770	COG1929	Belongs to the glycerate kinase type-1 family
AH4AK4_RS02785	COG0583	DNA-binding transcription factor activity
AH4AK4_RS02790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AH4AK4_RS02805	COG0347	Belongs to the P(II) protein family
AH4AK4_RS02810	COG1840	ABC-type Fe3 transport system, periplasmic component
AH4AK4_RS02820	COG3842	ATPase activity
AH4AK4_RS02825	COG2837	iron assimilation
AH4AK4_RS02830	COG1438	arginine binding
AH4AK4_RS02835	COG1126	abc transporter atp-binding protein
AH4AK4_RS02840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_RS02845	COG4215	(ABC) transporter
AH4AK4_RS02850	COG4160	amino acid transport
AH4AK4_RS02855	COG0039	L-malate dehydrogenase activity
AH4AK4_RS02860	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AH4AK4_RS02865	COG1017	nitric oxide dioxygenase activity
AH4AK4_RS02865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AH4AK4_RS02875	COG4536	flavin adenine dinucleotide binding
AH4AK4_RS02880	COG4137	Cytochrome C assembly protein
AH4AK4_RS02885	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AH4AK4_RS02890	COG0228	four-way junction DNA binding
AH4AK4_RS02895	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AH4AK4_RS02900	COG0336	Belongs to the RNA methyltransferase TrmD family
AH4AK4_RS02905	COG0335	large ribosomal subunit rRNA binding
AH4AK4_RS02920	COG1051	belongs to the nudix hydrolase family
AH4AK4_RS02930	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AH4AK4_RS02935	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AH4AK4_RS02940	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AH4AK4_RS02950	COG0583	DNA-binding transcription factor activity
AH4AK4_RS02955	COG0640	Transcriptional regulator
AH4AK4_RS02960	COG0268	Binds directly to 16S ribosomal RNA
AH4AK4_RS02965	COG0728	peptidoglycan biosynthetic process
AH4AK4_RS02970	COG0196	riboflavin kinase activity
AH4AK4_RS02975	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AH4AK4_RS02980	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AH4AK4_RS02985	COG1047	Peptidyl-prolyl cis-trans
AH4AK4_RS02990	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AH4AK4_RS03030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AH4AK4_RS03030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AH4AK4_RS03045	COG1854	S-ribosylhomocysteine lyase activity
AH4AK4_RS03050	COG3706	GGDEF domain
AH4AK4_RS03055	COG0557	exoribonuclease II activity
AH4AK4_RS03060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AH4AK4_RS03070	COG2153	protein acetylation
AH4AK4_RS03080	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AH4AK4_RS03085	COG1914	H( )-stimulated, divalent metal cation uptake system
AH4AK4_RS03090	COG0360	Binds together with S18 to 16S ribosomal RNA
AH4AK4_RS03095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AH4AK4_RS03100	COG0359	binds to the 23S rRNA
AH4AK4_RS03125	COG1064	alcohol dehydrogenase
AH4AK4_RS03130	COG1238	metal cluster binding
AH4AK4_RS03135	COG0612	Peptidase, M16
AH4AK4_RS03140	COG2918	glutathione biosynthetic process
AH4AK4_RS03145	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AH4AK4_RS03150	COG1027	Aspartate ammonia-lyase
AH4AK4_RS03155	COG3030	protein affecting phage T7 exclusion by the F plasmid
AH4AK4_RS03160	COG0534	Mate efflux family protein
AH4AK4_RS03165	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AH4AK4_RS03170	COG0459	protein refolding
AH4AK4_RS03190	COG0564	pseudouridine synthase activity
AH4AK4_RS03195	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AH4AK4_RS03225	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AH4AK4_RS03235	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AH4AK4_RS03240	COG4208	sulfate ABC transporter
AH4AK4_RS03245	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AH4AK4_RS03250	COG0583	DNA-binding transcription factor activity
AH4AK4_RS03260	COG3397	chitin binding
AH4AK4_RS03290	COG1328	CTP reductase activity
AH4AK4_RS03295	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AH4AK4_RS03310	COG1448	Aminotransferase
AH4AK4_RS03315	COG2194	sulfuric ester hydrolase activity
AH4AK4_RS03335	COG1215	transferase activity, transferring glycosyl groups
AH4AK4_RS03345	COG0457	Tetratricopeptide repeat
AH4AK4_RS03345	COG3118	belongs to the thioredoxin family
AH4AK4_RS03380	COG0513	Belongs to the DEAD box helicase family
AH4AK4_RS03395	COG0840	transmembrane signaling receptor activity
AH4AK4_RS03405	COG4166	transmembrane transport
AH4AK4_RS03415	COG0110	maltose O-acetyltransferase activity
AH4AK4_RS03425	COG1024	Enoyl-CoA hydratase
AH4AK4_RS03440	COG4221	oxidoreductase activity
AH4AK4_RS03445	COG0442	prolyl-tRNA aminoacylation
AH4AK4_RS03450	COG0840	transmembrane signaling receptor activity
AH4AK4_RS03455	COG0632	four-way junction helicase activity
AH4AK4_RS03460	COG2255	four-way junction helicase activity
AH4AK4_RS03465	COG1271	oxidase subunit
AH4AK4_RS03470	COG1294	oxidase, subunit
AH4AK4_RS03480	COG3790	cyd operon protein YbgE
AH4AK4_RS03485	COG0824	Thioesterase
AH4AK4_RS03490	COG0811	peptide transport
AH4AK4_RS03505	COG0823	Involved in the tonB-independent uptake of proteins
AH4AK4_RS03510	COG2885	chlorophyll binding
AH4AK4_RS03515	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AH4AK4_RS03540	COG0840	transmembrane signaling receptor activity
AH4AK4_RS03545	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AH4AK4_RS03555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AH4AK4_RS03560	COG1640	4-alpha-glucanotransferase
AH4AK4_RS03565	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AH4AK4_RS03590	COG2130	NADP-dependent
AH4AK4_RS03595	COG1846	Transcriptional regulator
AH4AK4_RS03625	COG0561	phosphatase activity
AH4AK4_RS03640	COG0733	neurotransmitter:sodium symporter activity
AH4AK4_RS03645	COG0733	neurotransmitter:sodium symporter activity
AH4AK4_RS03660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AH4AK4_RS03675	COG1794	racemase activity, acting on amino acids and derivatives
AH4AK4_RS03685	COG1022	Amp-dependent synthetase and ligase
AH4AK4_RS03695	COG0456	acetyltransferase
AH4AK4_RS03710	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AH4AK4_RS03715	COG5001	Diguanylate cyclase
AH4AK4_RS03715	COG3300	MHYT domain
AH4AK4_RS03725	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AH4AK4_RS03740	COG1902	pentaerythritol trinitrate reductase activity
AH4AK4_RS03760	COG2957	Belongs to the agmatine deiminase family
AH4AK4_RS03765	COG0154	amidase activity
AH4AK4_RS03800	COG0513	Belongs to the DEAD box helicase family
AH4AK4_RS03805	COG2203	Gaf domain
AH4AK4_RS03805	COG2199	diguanylate cyclase activity
AH4AK4_RS03840	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
AH4AK4_RS03895	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AH4AK4_RS03900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AH4AK4_RS03910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AH4AK4_RS03940	COG0745	RESPONSE REGULATOR receiver
AH4AK4_RS03945	COG3104	oligopeptide transport
AH4AK4_RS03950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AH4AK4_RS03955	COG1555	photosystem II stabilization
AH4AK4_RS03965	COG2350	Protein conserved in bacteria
AH4AK4_RS03970	COG2917	probably involved in intracellular septation
AH4AK4_RS03975	COG0076	glutamate decarboxylase activity
AH4AK4_RS03980	COG1272	protein, Hemolysin III
AH4AK4_RS03985	COG2985	domain, Protein
AH4AK4_RS03985	COG0569	domain protein
AH4AK4_RS03995	COG0477	Major facilitator Superfamily
AH4AK4_RS04000	COG0583	DNA-binding transcription factor activity
AH4AK4_RS04010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AH4AK4_RS04015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AH4AK4_RS04025	COG2731	YhcH YjgK YiaL family protein
AH4AK4_RS04035	COG0668	transmembrane transport
AH4AK4_RS04040	COG1376	ErfK ybiS ycfS ynhG family protein
AH4AK4_RS04045	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AH4AK4_RS04060	COG0789	Transcriptional regulator
AH4AK4_RS04080	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AH4AK4_RS04090	COG0488	(ABC) transporter
AH4AK4_RS04095	COG0517	IMP dehydrogenase activity
AH4AK4_RS04095	COG0516	GMP reductase activity
AH4AK4_RS04100	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AH4AK4_RS04105	COG0835	chemotaxis
AH4AK4_RS04105	COG0784	Response regulator, receiver
AH4AK4_RS04110	COG2755	lipolytic protein G-D-S-L family
AH4AK4_RS04115	COG4181	ATPase activity
AH4AK4_RS04120	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AH4AK4_RS04125	COG1090	epimerase
AH4AK4_RS04130	COG2200	EAL domain
AH4AK4_RS04135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AH4AK4_RS04140	COG4935	Belongs to the peptidase S8 family
AH4AK4_RS04140	COG2234	aminopeptidase activity
AH4AK4_RS04145	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AH4AK4_RS04150	COG3171	Protein conserved in bacteria
AH4AK4_RS04155	COG2066	Belongs to the glutaminase family
AH4AK4_RS04160	COG2897	thiosulfate sulfurtransferase activity
AH4AK4_RS04165	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AH4AK4_RS04240	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
AH4AK4_RS04245	COG3300	MHYT domain
AH4AK4_RS04245	COG5001	Diguanylate cyclase
AH4AK4_RS04265	COG4628	conserved protein (DUF2132)
AH4AK4_RS04270	COG0688	phosphatidylethanolamine metabolic process
AH4AK4_RS04280	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AH4AK4_RS04310	COG1278	Cold shock
AH4AK4_RS04320	COG0840	transmembrane signaling receptor activity
AH4AK4_RS04325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AH4AK4_RS04375	COG0848	biopolymer transport protein
AH4AK4_RS04380	COG0811	peptide transport
AH4AK4_RS04385	COG0811	peptide transport
AH4AK4_RS04395	COG4206	TonB-dependent receptor
AH4AK4_RS04400	COG4174	ABC transporter (Permease)
AH4AK4_RS04405	COG4239	(ABC) transporter, permease
AH4AK4_RS04415	COG0444	Belongs to the ABC transporter superfamily
AH4AK4_RS04420	COG4608	Belongs to the ABC transporter superfamily
AH4AK4_RS04425	COG2195	Cleaves the N-terminal amino acid of tripeptides
AH4AK4_RS04430	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AH4AK4_RS04435	COG1073	alpha beta
AH4AK4_RS04450	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AH4AK4_RS04480	COG0243	molybdopterin cofactor binding
AH4AK4_RS04495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AH4AK4_RS04495	COG1116	anion transmembrane transporter activity
AH4AK4_RS04500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AH4AK4_RS04505	COG1116	anion transmembrane transporter activity
AH4AK4_RS04510	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AH4AK4_RS04510	COG2146	nitrite reductase [NAD(P)H] activity
AH4AK4_RS04515	COG2146	nitrite reductase [NAD(P)H] activity
AH4AK4_RS04515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AH4AK4_RS04520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AH4AK4_RS04525	COG2313	pseudouridylate synthase activity
AH4AK4_RS04535	COG1858	cytochrome C peroxidase
AH4AK4_RS04550	COG0521	Mo-molybdopterin cofactor biosynthetic process
AH4AK4_RS04560	COG2966	Psort location CytoplasmicMembrane, score
AH4AK4_RS04565	COG3610	response to peptide
AH4AK4_RS04575	COG4175	Glycine betaine
AH4AK4_RS04580	COG4176	ABC-type proline glycine betaine transport system permease component
AH4AK4_RS04585	COG2113	Glycine betaine
AH4AK4_RS04590	COG0175	sulfate reduction
AH4AK4_RS04595	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AH4AK4_RS04605	COG0384	phenazine biosynthesis protein PhzF
AH4AK4_RS04610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AH4AK4_RS04615	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AH4AK4_RS04625	COG0786	glutamate:sodium symporter activity
AH4AK4_RS04630	COG0252	asparaginase activity
AH4AK4_RS04635	COG3139	Protein of unknown function (DUF1315)
AH4AK4_RS04655	COG0616	signal peptide processing
AH4AK4_RS04660	COG0446	pyridine nucleotide-disulphide oxidoreductase
AH4AK4_RS04660	COG1902	pentaerythritol trinitrate reductase activity
AH4AK4_RS04665	COG0778	Nitroreductase
AH4AK4_RS04675	COG2264	protein methyltransferase activity
AH4AK4_RS04680	COG0604	alcohol dehydrogenase
AH4AK4_RS04685	COG0583	DNA-binding transcription factor activity
AH4AK4_RS04690	COG1263	PTS System
AH4AK4_RS04690	COG2190	(PTS) system
AH4AK4_RS04690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AH4AK4_RS04695	COG4145	pantothenate transmembrane transporter activity
AH4AK4_RS04700	COG3924	membrane
AH4AK4_RS04705	COG0439	Biotin carboxylase
AH4AK4_RS04710	COG0511	ligase activity, forming carbon-carbon bonds
AH4AK4_RS04715	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AH4AK4_RS04720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AH4AK4_RS04735	COG3381	protein complex oligomerization
AH4AK4_RS04745	COG3005	denitrification pathway
AH4AK4_RS04750	COG0745	RESPONSE REGULATOR receiver
AH4AK4_RS04755	COG1879	ABC-type sugar transport system periplasmic component
AH4AK4_RS04760	COG2205	protein histidine kinase activity
AH4AK4_RS04760	COG2198	Histidine kinase
AH4AK4_RS04760	COG0784	Response regulator, receiver
AH4AK4_RS04770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AH4AK4_RS04775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AH4AK4_RS04780	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AH4AK4_RS04780	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AH4AK4_RS04795	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AH4AK4_RS04800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AH4AK4_RS04805	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AH4AK4_RS04810	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AH4AK4_RS04815	COG4172	Belongs to the ABC transporter superfamily
AH4AK4_RS04825	COG0601	transmembrane transport
AH4AK4_RS04835	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AH4AK4_RS04840	COG0142	geranyltranstransferase activity
AH4AK4_RS04845	COG1722	exodeoxyribonuclease VII activity
AH4AK4_RS04850	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AH4AK4_RS04855	COG1360	Flagellar Motor Protein
AH4AK4_RS04860	COG2823	Periplasmic or secreted lipoprotein
AH4AK4_RS04865	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AH4AK4_RS04870	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AH4AK4_RS04910	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
AH4AK4_RS04925	COG1534	Rna-binding protein
AH4AK4_RS04930	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AH4AK4_RS04940	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AH4AK4_RS04945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AH4AK4_RS04950	COG0149	triose-phosphate isomerase activity
AH4AK4_RS04955	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AH4AK4_RS04970	COG0779	Required for maturation of 30S ribosomal subunits
AH4AK4_RS04975	COG0195	Participates in both transcription termination and antitermination
AH4AK4_RS04980	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AH4AK4_RS04985	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AH4AK4_RS04990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AH4AK4_RS04995	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AH4AK4_RS05000	COG1185	polyribonucleotide nucleotidyltransferase activity
AH4AK4_RS05005	COG2211	Major facilitator Superfamily
AH4AK4_RS05010	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AH4AK4_RS05020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AH4AK4_RS05025	COG0826	peptidase U32
AH4AK4_RS05040	COG0312	modulator of DNA gyrase
AH4AK4_RS05055	COG4974	Belongs to the 'phage' integrase family
AH4AK4_RS05060	COG1970	mechanosensitive ion channel activity
AH4AK4_RS05070	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AH4AK4_RS05080	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AH4AK4_RS05090	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AH4AK4_RS05095	COG0321	lipoyl(octanoyl) transferase activity
AH4AK4_RS05100	COG2921	Belongs to the UPF0250 family
AH4AK4_RS05105	COG1686	Belongs to the peptidase S11 family
AH4AK4_RS05110	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AH4AK4_RS05115	COG2951	lytic endotransglycosylase activity
AH4AK4_RS05120	COG0772	Belongs to the SEDS family
AH4AK4_RS05125	COG0768	penicillin binding
AH4AK4_RS05130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AH4AK4_RS05135	COG0799	negative regulation of ribosome biogenesis
AH4AK4_RS05140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AH4AK4_RS05155	COG0495	leucyl-tRNA aminoacylation
AH4AK4_RS05160	COG2888	peptidyl-tyrosine sulfation
AH4AK4_RS05165	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AH4AK4_RS05170	COG4535	Mg2 and Co2 transporter CorC
AH4AK4_RS05175	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AH4AK4_RS05180	COG1702	phosphate starvation-inducible protein PhoH
AH4AK4_RS05185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AH4AK4_RS05190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AH4AK4_RS05195	COG1335	isochorismatase
AH4AK4_RS05200	COG0583	DNA-binding transcription factor activity
AH4AK4_RS05210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AH4AK4_RS05220	COG3706	GGDEF domain
AH4AK4_RS05230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AH4AK4_RS05240	COG3647	Membrane
AH4AK4_RS05245	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AH4AK4_RS05255	COG0516	GMP reductase activity
AH4AK4_RS05265	COG0642	Histidine kinase
AH4AK4_RS05280	COG0300	oxidoreductase activity
AH4AK4_RS05290	COG1022	Amp-dependent synthetase and ligase
AH4AK4_RS05300	COG4106	trans-aconitate 2-methyltransferase activity
AH4AK4_RS05305	COG3214	Protein conserved in bacteria
AH4AK4_RS05310	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AH4AK4_RS05315	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AH4AK4_RS05320	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AH4AK4_RS05325	COG1053	succinate dehydrogenase
AH4AK4_RS05335	COG0584	glycerophosphoryl diester phosphodiesterase
AH4AK4_RS05340	COG3264	Mechanosensitive ion channel
AH4AK4_RS05340	COG1511	domain protein
AH4AK4_RS05350	COG0739	heme binding
AH4AK4_RS05360	COG3121	Chaperone
AH4AK4_RS05365	COG3188	usher protein
AH4AK4_RS05370	COG3121	Chaperone
AH4AK4_RS05385	COG0583	DNA-binding transcription factor activity
AH4AK4_RS05400	COG0583	DNA-binding transcription factor activity
AH4AK4_RS05405	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AH4AK4_RS05435	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AH4AK4_RS05440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AH4AK4_RS05450	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AH4AK4_RS05455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AH4AK4_RS05465	COG0180	Tryptophanyl-tRNA synthetase
AH4AK4_RS05480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AH4AK4_RS05490	COG1012	belongs to the aldehyde dehydrogenase family
AH4AK4_RS05500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AH4AK4_RS05515	COG0488	(ABC) transporter
AH4AK4_RS05520	COG0366	Alpha amylase catalytic
AH4AK4_RS05530	COG0657	acetylesterase activity
AH4AK4_RS05540	COG0471	metal ion transport
AH4AK4_RS05540	COG0490	domain, Protein
AH4AK4_RS05585	COG0012	GTP binding
AH4AK4_RS05590	COG0193	aminoacyl-tRNA hydrolase activity
AH4AK4_RS05595	COG0737	Belongs to the 5'-nucleotidase family
AH4AK4_RS05600	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AH4AK4_RS05615	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AH4AK4_RS05620	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AH4AK4_RS05625	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AH4AK4_RS05630	COG2890	protein-(glutamine-N5) methyltransferase activity
AH4AK4_RS05640	COG2912	Transglutaminase-like superfamily
AH4AK4_RS05650	COG1301	dicarboxylic acid transport
AH4AK4_RS05660	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AH4AK4_RS05675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AH4AK4_RS05680	COG1115	amino acid carrier protein
AH4AK4_RS05700	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AH4AK4_RS05710	COG0189	ligase activity
AH4AK4_RS05715	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AH4AK4_RS05725	COG3091	SprT-like family
AH4AK4_RS05735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AH4AK4_RS05755	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AH4AK4_RS05760	COG0739	heme binding
AH4AK4_RS05765	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AH4AK4_RS05770	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AH4AK4_RS05770	COG3408	Glycogen debranching enzyme
AH4AK4_RS05780	COG1881	PFAM PEBP family protein
AH4AK4_RS05785	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AH4AK4_RS05790	COG0583	DNA-binding transcription factor activity
AH4AK4_RS05800	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AH4AK4_RS05810	COG0583	DNA-binding transcription factor activity
AH4AK4_RS05815	COG1028	Short-chain dehydrogenase reductase Sdr
AH4AK4_RS05820	COG0616	signal peptide processing
AH4AK4_RS05825	COG3724	N-succinylarginine dihydrolase activity
AH4AK4_RS05840	COG0840	transmembrane signaling receptor activity
AH4AK4_RS05850	COG2971	BadF BadG BcrA BcrD
AH4AK4_RS05860	COG4608	Belongs to the ABC transporter superfamily
AH4AK4_RS05865	COG0444	Belongs to the ABC transporter superfamily
AH4AK4_RS05870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AH4AK4_RS05890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AH4AK4_RS05910	COG1677	Flagellar hook-basal body complex protein FliE
AH4AK4_RS05920	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AH4AK4_RS05975	COG1684	flagellar biosynthetic protein fliR
AH4AK4_RS05985	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AH4AK4_RS06010	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AH4AK4_RS06015	COG2198	Histidine kinase
AH4AK4_RS06015	COG0784	Response regulator, receiver
AH4AK4_RS06015	COG0643	Histidine kinase
AH4AK4_RS06020	COG2201	protein-glutamate methylesterase activity
AH4AK4_RS06025	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AH4AK4_RS06030	COG1360	Flagellar Motor Protein
AH4AK4_RS06035	COG1192	Involved in chromosome partitioning
AH4AK4_RS06045	COG0835	chemotaxis
AH4AK4_RS06060	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AH4AK4_RS06065	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AH4AK4_RS06070	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AH4AK4_RS06075	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AH4AK4_RS06080	COG1138	Cytochrome C-type biogenesis protein
AH4AK4_RS06085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AH4AK4_RS06090	COG4235	cytochrome complex assembly
AH4AK4_RS06090	COG3088	subunit of a heme lyase
AH4AK4_RS06095	COG0457	Tetratricopeptide repeat
AH4AK4_RS06110	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AH4AK4_RS06115	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AH4AK4_RS06115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AH4AK4_RS06130	COG0259	pyridoxamine-phosphate oxidase activity
AH4AK4_RS06160	COG3153	acetyltransferase
AH4AK4_RS06175	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AH4AK4_RS06180	COG2867	negative regulation of translational initiation
AH4AK4_RS06185	COG2914	Belongs to the UPF0125 (RnfH) family
AH4AK4_RS06190	COG0702	epimerase
AH4AK4_RS06195	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AH4AK4_RS06200	COG1454	alcohol dehydrogenase
AH4AK4_RS06240	COG1280	lysine exporter protein (LysE YggA)
AH4AK4_RS06250	COG3263	regulation of cellular component size
AH4AK4_RS06255	COG1876	peptidase activity
AH4AK4_RS06260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AH4AK4_RS06265	COG1393	Belongs to the ArsC family
AH4AK4_RS06275	COG3069	C4-dicarboxylate transmembrane transporter activity
AH4AK4_RS06280	COG1473	amidohydrolase
AH4AK4_RS06290	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AH4AK4_RS06300	COG1902	pentaerythritol trinitrate reductase activity
AH4AK4_RS06305	COG4221	oxidoreductase activity
AH4AK4_RS06310	COG3321	synthase
AH4AK4_RS06310	COG1028	Short-chain dehydrogenase reductase Sdr
AH4AK4_RS06310	COG0604	alcohol dehydrogenase
AH4AK4_RS06315	COG0017	Asparaginyl-tRNA synthetase
AH4AK4_RS06335	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AH4AK4_RS06340	COG0156	8-amino-7-oxononanoate synthase activity
AH4AK4_RS06345	COG1073	alpha beta
AH4AK4_RS06345	COG2226	methyltransferase
AH4AK4_RS06350	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AH4AK4_RS06355	COG0501	Belongs to the peptidase M48B family
AH4AK4_RS06360	COG0633	Ferredoxin
AH4AK4_RS06360	COG3217	Mosc domain protein beta barrel domain protein
AH4AK4_RS06360	COG0633	Ferredoxin
AH4AK4_RS06360	COG3217	Mosc domain protein beta barrel domain protein
AH4AK4_RS06370	COG0674	pyruvate-flavodoxin oxidoreductase activity
AH4AK4_RS06370	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AH4AK4_RS06370	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AH4AK4_RS06370	COG1013	pyruvate-flavodoxin oxidoreductase activity
AH4AK4_RS06375	COG2841	Protein conserved in bacteria
AH4AK4_RS06385	COG0534	Mate efflux family protein
AH4AK4_RS06420	COG1309	transcriptional regulator
AH4AK4_RS06435	COG0791	NLP P60 protein
AH4AK4_RS06440	COG0583	DNA-binding transcription factor activity
AH4AK4_RS06460	COG0500	methyltransferase
AH4AK4_RS06465	COG4106	trans-aconitate 2-methyltransferase activity
AH4AK4_RS06470	COG1801	Protein of unknown function DUF72
AH4AK4_RS06475	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AH4AK4_RS06480	COG0217	transcriptional regulatory protein
AH4AK4_RS06490	COG1940	carbohydrate kinase activity
AH4AK4_RS06490	COG1846	Transcriptional regulator
AH4AK4_RS06495	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AH4AK4_RS06500	COG0363	glucosamine-6-phosphate deaminase activity
AH4AK4_RS06505	COG1263	PTS System
AH4AK4_RS06505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AH4AK4_RS06505	COG2190	(PTS) system
AH4AK4_RS06525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AH4AK4_RS06525	COG2010	Cytochrome c
AH4AK4_RS06530	COG2080	2 iron, 2 sulfur cluster binding
AH4AK4_RS06535	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AH4AK4_RS06540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AH4AK4_RS06545	COG0735	belongs to the Fur family
AH4AK4_RS06555	COG0716	FMN binding
AH4AK4_RS06570	COG0596	Alpha beta hydrolase
AH4AK4_RS06575	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AH4AK4_RS06580	COG0033	Phosphoglucomutase
AH4AK4_RS06595	COG2951	lytic endotransglycosylase activity
AH4AK4_RS06600	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AH4AK4_RS06605	COG4136	ATPase activity
AH4AK4_RS06615	COG4134	Bacterial extracellular solute-binding protein
AH4AK4_RS06625	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AH4AK4_RS06635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AH4AK4_RS06650	COG0729	surface antigen
AH4AK4_RS06655	COG2911	Protein conserved in bacteria
AH4AK4_RS06675	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AH4AK4_RS06685	COG0741	lytic transglycosylase activity
AH4AK4_RS06700	COG1607	acyl-coa hydrolase
AH4AK4_RS06710	COG3021	interspecies interaction between organisms
AH4AK4_RS06715	COG1388	LysM domain
AH4AK4_RS06715	COG0741	lytic transglycosylase activity
AH4AK4_RS06720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AH4AK4_RS06725	COG2226	methyltransferase
AH4AK4_RS06730	COG0328	RNA-DNA hybrid ribonuclease activity
AH4AK4_RS06735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AH4AK4_RS06745	COG0784	Response regulator, receiver
AH4AK4_RS06745	COG3437	response regulator, receiver
AH4AK4_RS06755	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AH4AK4_RS06760	COG0121	glutamine amidotransferase
AH4AK4_RS06770	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AH4AK4_RS06795	COG2197	response regulator
AH4AK4_RS06800	COG3850	Histidine kinase
AH4AK4_RS06805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AH4AK4_RS06810	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AH4AK4_RS06820	COG0243	molybdopterin cofactor binding
AH4AK4_RS06825	COG0437	4 iron, 4 sulfur cluster binding
AH4AK4_RS06830	COG0348	domain, Protein
AH4AK4_RS06840	COG3005	denitrification pathway
AH4AK4_RS06845	COG0521	Mo-molybdopterin cofactor biosynthetic process
AH4AK4_RS06850	COG0315	cyclic pyranopterin monophosphate synthase activity
AH4AK4_RS06855	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AH4AK4_RS06860	COG0314	molybdopterin synthase activity
AH4AK4_RS06875	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AH4AK4_RS06880	COG2267	carboxylic ester hydrolase activity
AH4AK4_RS06895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AH4AK4_RS06900	COG0303	'Molybdopterin
AH4AK4_RS06910	COG0302	gtp cyclohydrolase
AH4AK4_RS06915	COG0840	transmembrane signaling receptor activity
AH4AK4_RS06920	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AH4AK4_RS06930	COG0583	DNA-binding transcription factor activity
AH4AK4_RS06945	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AH4AK4_RS06960	COG2195	Cleaves the N-terminal amino acid of tripeptides
AH4AK4_RS06965	COG1166	arginine decarboxylase activity
AH4AK4_RS06980	COG1403	HNH endonuclease
AH4AK4_RS07000	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AH4AK4_RS07005	COG1187	pseudouridine synthase activity
AH4AK4_RS07010	COG2807	transmembrane transport
AH4AK4_RS07020	COG0583	DNA-binding transcription factor activity
AH4AK4_RS07040	COG2979	Protein of unknown function (DUF533)
AH4AK4_RS07050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AH4AK4_RS07060	COG1294	oxidase, subunit
AH4AK4_RS07070	COG2814	Major facilitator Superfamily
AH4AK4_RS07075	COG0656	L-ascorbic acid biosynthetic process
AH4AK4_RS07095	COG0583	DNA-binding transcription factor activity
AH4AK4_RS07100	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AH4AK4_RS07105	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AH4AK4_RS07110	COG2271	Major facilitator Superfamily
AH4AK4_RS07115	COG1349	DNA-binding transcription factor activity
AH4AK4_RS07125	COG0584	glycerophosphoryl diester phosphodiesterase
AH4AK4_RS07130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AH4AK4_RS07135	COG0287	Prephenate dehydrogenase
AH4AK4_RS07135	COG1605	Chorismate mutase
AH4AK4_RS07145	COG3085	chromosome segregation
AH4AK4_RS07150	COG4574	serine-type endopeptidase inhibitor activity
AH4AK4_RS07170	COG1770	oligopeptidase
AH4AK4_RS07175	COG4206	TonB-dependent receptor
AH4AK4_RS07180	COG3083	sulfuric ester hydrolase activity
AH4AK4_RS07185	COG3082	Protein of unknown function (DUF1414)
AH4AK4_RS07190	COG3081	Nucleoid-associated protein
AH4AK4_RS07195	COG2182	Extracellular solute-binding protein
AH4AK4_RS07200	COG1175	transmembrane transport
AH4AK4_RS07205	COG3833	ABC-type maltose transport systems, permease component
AH4AK4_RS07210	COG3842	ATPase activity
AH4AK4_RS07235	COG0425	Belongs to the sulfur carrier protein TusA family
AH4AK4_RS07240	COG4783	chaperone-mediated protein folding
AH4AK4_RS07245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AH4AK4_RS07250	COG1393	Belongs to the ArsC family
AH4AK4_RS07260	COG1228	amidohydrolase
AH4AK4_RS07270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_RS07275	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AH4AK4_RS07280	COG2431	L-lysine efflux transmembrane transporter activity
AH4AK4_RS07290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_RS07310	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AH4AK4_RS07320	COG0446	pyridine nucleotide-disulphide oxidoreductase
AH4AK4_RS07350	COG2373	Large extracellular alpha-helical protein
AH4AK4_RS07355	COG4953	penicillin-binding protein 1C
AH4AK4_RS07365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AH4AK4_RS07365	COG0301	tRNA thio-modification
AH4AK4_RS07380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AH4AK4_RS07390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AH4AK4_RS07395	COG1334	flagellar protein FlaG
AH4AK4_RS07425	COG2089	acid synthase
AH4AK4_RS07440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AH4AK4_RS07445	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
AH4AK4_RS07455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AH4AK4_RS07460	COG1086	Polysaccharide biosynthesis protein
AH4AK4_RS07475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AH4AK4_RS07490	COG0840	transmembrane signaling receptor activity
AH4AK4_RS07495	COG0346	lactoylglutathione lyase activity
AH4AK4_RS07500	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AH4AK4_RS07505	COG4660	Part of a membrane complex involved in electron transport
AH4AK4_RS07510	COG4659	FMN binding
AH4AK4_RS07515	COG4658	electron transport chain
AH4AK4_RS07520	COG4656	Part of a membrane complex involved in electron transport
AH4AK4_RS07525	COG2878	Part of a membrane complex involved in electron transport
AH4AK4_RS07530	COG4657	Part of a membrane complex involved in electron transport
AH4AK4_RS07535	COG0697	spore germination
AH4AK4_RS07555	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AH4AK4_RS07560	COG1288	antiporter activity
AH4AK4_RS07565	COG0436	Aminotransferase
AH4AK4_RS07575	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AH4AK4_RS07580	COG2027	D-alanyl-D-alanine carboxypeptidase
AH4AK4_RS07585	COG1061	Type III restriction enzyme res subunit
AH4AK4_RS07590	COG1566	PFAM secretion protein HlyD family protein
AH4AK4_RS07600	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AH4AK4_RS07600	COG3264	Mechanosensitive ion channel
AH4AK4_RS07605	COG1966	Carbon starvation protein
AH4AK4_RS07610	COG3279	Response regulator of the LytR AlgR family
AH4AK4_RS07615	COG3275	phosphorelay sensor kinase activity
AH4AK4_RS07625	COG1454	alcohol dehydrogenase
AH4AK4_RS07625	COG1012	belongs to the aldehyde dehydrogenase family
AH4AK4_RS07630	COG2095	MarC family integral membrane protein
AH4AK4_RS07640	COG0601	transmembrane transport
AH4AK4_RS07645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AH4AK4_RS07650	COG0444	Belongs to the ABC transporter superfamily
AH4AK4_RS07660	COG0861	Integral membrane protein TerC family
AH4AK4_RS07665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AH4AK4_RS07675	COG1301	dicarboxylic acid transport
AH4AK4_RS07690	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AH4AK4_RS07705	COG0537	adenosine 5'-monophosphoramidase activity
AH4AK4_RS07740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AH4AK4_RS07745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AH4AK4_RS07760	COG2354	Protein conserved in bacteria
AH4AK4_RS07775	COG3150	esterase
AH4AK4_RS07780	COG1252	NADH dehydrogenase
AH4AK4_RS07785	COG0393	Putative heavy-metal-binding
AH4AK4_RS07790	COG1368	sulfuric ester hydrolase activity
AH4AK4_RS07800	COG0527	aspartate kinase activity
AH4AK4_RS07805	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AH4AK4_RS07805	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AH4AK4_RS07810	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AH4AK4_RS07840	COG0577	efflux transmembrane transporter activity
AH4AK4_RS07845	COG1136	(ABC) transporter
AH4AK4_RS07865	COG2814	Major facilitator Superfamily
AH4AK4_RS07885	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AH4AK4_RS07885	COG0493	'glutamate synthase
AH4AK4_RS07890	COG0672	)-iron permease
AH4AK4_RS07925	COG2308	Evidence 4 Homologs of previously reported genes of
AH4AK4_RS07950	COG0659	secondary active sulfate transmembrane transporter activity
AH4AK4_RS07975	COG3501	Rhs element vgr protein
AH4AK4_RS08050	COG3829	transcription factor binding
AH4AK4_RS08095	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AH4AK4_RS08100	COG0437	4 iron, 4 sulfur cluster binding
AH4AK4_RS08105	COG5557	Pfam Polysulphide reductase, NrfD
AH4AK4_RS08110	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AH4AK4_RS08115	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AH4AK4_RS08120	COG1773	rubredoxin
AH4AK4_RS08130	COG0601	transmembrane transport
AH4AK4_RS08135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AH4AK4_RS08145	COG1124	(ABC) transporter
AH4AK4_RS08150	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AH4AK4_RS08155	COG0375	protein maturation
AH4AK4_RS08160	COG0309	Hydrogenase expression formation protein (HypE)
AH4AK4_RS08170	COG0298	carbon dioxide binding
AH4AK4_RS08175	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AH4AK4_RS08180	COG3158	transport of potassium into the cell
AH4AK4_RS08190	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AH4AK4_RS08195	COG0326	Molecular chaperone. Has ATPase activity
AH4AK4_RS08200	COG0563	adenylate kinase activity
AH4AK4_RS08205	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AH4AK4_RS08215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AH4AK4_RS08220	COG0840	transmembrane signaling receptor activity
AH4AK4_RS08235	COG5001	Diguanylate cyclase
AH4AK4_RS08235	COG3300	MHYT domain
AH4AK4_RS08240	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AH4AK4_RS08260	COG1021	2,3-dihydroxybenzoate-AMP ligase
AH4AK4_RS08265	COG1535	isochorismatase
AH4AK4_RS08265	COG3433	isochorismatase activity
AH4AK4_RS08270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AH4AK4_RS08275	COG1028	Short-chain dehydrogenase reductase Sdr
AH4AK4_RS08285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AH4AK4_RS08290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AH4AK4_RS08295	COG2977	Belongs to the P-Pant transferase superfamily
AH4AK4_RS08300	COG1120	ATPase activity
AH4AK4_RS08305	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AH4AK4_RS08310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AH4AK4_RS08315	COG4771	TonB-dependent receptor
AH4AK4_RS08355	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AH4AK4_RS08360	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AH4AK4_RS08365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AH4AK4_RS08370	COG0861	Integral membrane protein TerC family
AH4AK4_RS08385	COG1022	Amp-dependent synthetase and ligase
AH4AK4_RS08390	COG0295	cytidine deaminase activity
AH4AK4_RS08395	COG1346	cytolysis
AH4AK4_RS08405	COG3345	alpha-galactosidase
AH4AK4_RS08415	COG2925	Exonuclease
AH4AK4_RS08420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AH4AK4_RS08430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AH4AK4_RS08435	COG0436	Aminotransferase
AH4AK4_RS08440	COG0583	DNA-binding transcription factor activity
AH4AK4_RS08445	COG2160	L-arabinose isomerase activity
AH4AK4_RS08455	COG1069	ribulokinase activity
AH4AK4_RS08460	COG1879	ABC-type sugar transport system periplasmic component
AH4AK4_RS08465	COG1129	ABC transporter
AH4AK4_RS08470	COG1172	Belongs to the binding-protein-dependent transport system permease family
AH4AK4_RS08480	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AH4AK4_RS08485	COG0254	rRNA binding
AH4AK4_RS08500	COG1451	nucleotide metabolic process
AH4AK4_RS08515	COG3069	C4-dicarboxylate transmembrane transporter activity
AH4AK4_RS08525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AH4AK4_RS08525	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AH4AK4_RS08530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AH4AK4_RS08555	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AH4AK4_RS08560	COG1053	succinate dehydrogenase
AH4AK4_RS08570	COG0567	Dehydrogenase, E1 component
AH4AK4_RS08575	COG0508	dehydrogenase complex catalyzes the overall conversion of
AH4AK4_RS08580	COG0045	succinate-CoA ligase (ADP-forming) activity
AH4AK4_RS08590	COG2983	Belongs to the UPF0260 family
AH4AK4_RS08595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AH4AK4_RS08605	COG3842	ATPase activity
AH4AK4_RS08610	COG1840	ABC-type Fe3 transport system, periplasmic component
AH4AK4_RS08620	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AH4AK4_RS08625	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AH4AK4_RS08630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AH4AK4_RS08635	COG1882	Formate acetyltransferase
AH4AK4_RS08640	COG2116	formate transmembrane transporter activity
AH4AK4_RS08645	COG1944	ATP diphosphatase activity
AH4AK4_RS08660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AH4AK4_RS08665	COG1278	Cold shock
AH4AK4_RS08670	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AH4AK4_RS08675	COG0542	response to heat
AH4AK4_RS08680	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AH4AK4_RS08685	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AH4AK4_RS08690	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AH4AK4_RS08695	COG3134	Outer membrane lipoprotein
AH4AK4_RS08700	COG3706	GGDEF domain
AH4AK4_RS08705	COG0492	ferredoxin-NADP+ reductase activity
AH4AK4_RS08710	COG0686	Belongs to the AlaDH PNT family
AH4AK4_RS08720	COG0531	amino acid
AH4AK4_RS08720	COG1674	ftsk spoiiie
AH4AK4_RS08725	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AH4AK4_RS08730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AH4AK4_RS08735	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AH4AK4_RS08740	COG1286	toxin biosynthetic process
AH4AK4_RS08745	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AH4AK4_RS08750	COG2723	6-phospho-beta-galactosidase activity
AH4AK4_RS08755	COG1263	PTS System
AH4AK4_RS08755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AH4AK4_RS08760	COG1609	Transcriptional regulator
AH4AK4_RS08770	COG4172	Belongs to the ABC transporter superfamily
AH4AK4_RS08785	COG4171	peptide transport system, permease
AH4AK4_RS08800	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AH4AK4_RS08805	COG1842	Phage shock protein A
AH4AK4_RS08820	COG3106	COG3106 Predicted ATPase
AH4AK4_RS08825	COG3768	UPF0283 membrane protein
AH4AK4_RS08835	COG2154	pterin-4-alpha-carbinolamine dehydratase
AH4AK4_RS08850	COG2199	diguanylate cyclase activity
AH4AK4_RS08855	COG2885	chlorophyll binding
AH4AK4_RS08865	COG1570	exodeoxyribonuclease VII activity
AH4AK4_RS08890	COG1874	Beta-galactosidase
AH4AK4_RS08890	COG0366	Alpha amylase catalytic
AH4AK4_RS08900	COG0516	GMP reductase activity
AH4AK4_RS08900	COG0517	IMP dehydrogenase activity
AH4AK4_RS08905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AH4AK4_RS08905	COG0519	Catalyzes the synthesis of GMP from XMP
AH4AK4_RS08945	COG2062	phosphohistidine phosphatase, SixA
AH4AK4_RS08955	COG0697	spore germination
AH4AK4_RS08960	COG4166	transmembrane transport
AH4AK4_RS08965	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AH4AK4_RS08970	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AH4AK4_RS08980	COG4591	ABC-type transport system involved in lipoprotein release permease component
AH4AK4_RS08985	COG1136	(ABC) transporter
AH4AK4_RS08990	COG4591	ABC-type transport system involved in lipoprotein release permease component
AH4AK4_RS08995	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AH4AK4_RS09010	COG0544	peptidyl-prolyl cis-trans isomerase activity
AH4AK4_RS09015	COG0740	serine-type endopeptidase activity
AH4AK4_RS09020	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AH4AK4_RS09025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AH4AK4_RS09030	COG0776	regulation of translation
AH4AK4_RS09035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AH4AK4_RS09040	COG0488	(ABC) transporter
AH4AK4_RS09045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AH4AK4_RS09050	COG3162	membrane
AH4AK4_RS09065	COG1024	Enoyl-CoA hydratase
AH4AK4_RS09070	COG1115	amino acid carrier protein
AH4AK4_RS09085	COG1584	GPR1 FUN34 yaaH family protein
AH4AK4_RS09110	COG1024	Enoyl-CoA hydratase
AH4AK4_RS09115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AH4AK4_RS09120	COG1960	acyl-CoA dehydrogenase activity
AH4AK4_RS09130	COG1960	acyl-CoA dehydrogenase activity
AH4AK4_RS09135	COG1024	Enoyl-CoA hydratase
AH4AK4_RS09140	COG1024	Enoyl-CoA hydratase
AH4AK4_RS09150	COG1028	Short-chain dehydrogenase reductase Sdr
AH4AK4_RS09160	COG0730	response to heat
AH4AK4_RS09165	COG1464	Belongs to the NlpA lipoprotein family
AH4AK4_RS09175	COG1172	Belongs to the binding-protein-dependent transport system permease family
AH4AK4_RS09180	COG1172	Belongs to the binding-protein-dependent transport system permease family
AH4AK4_RS09185	COG1129	ABC transporter
AH4AK4_RS09190	COG1879	ABC-type sugar transport system periplasmic component
AH4AK4_RS09210	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AH4AK4_RS09215	COG0243	molybdopterin cofactor binding
AH4AK4_RS09225	COG3706	GGDEF domain
AH4AK4_RS09230	COG0583	DNA-binding transcription factor activity
AH4AK4_RS09235	COG2723	6-phospho-beta-galactosidase activity
AH4AK4_RS09240	COG1028	Short-chain dehydrogenase reductase Sdr
AH4AK4_RS09245	COG0583	DNA-binding transcription factor activity
AH4AK4_RS09260	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AH4AK4_RS09265	COG0673	inositol 2-dehydrogenase activity
AH4AK4_RS09270	COG0583	DNA-binding transcription factor activity
AH4AK4_RS09280	COG1560	Kdo2-lipid A biosynthetic process
AH4AK4_RS09285	COG1560	Kdo2-lipid A biosynthetic process
AH4AK4_RS09310	COG0417	DNA replication proofreading
AH4AK4_RS09340	COG0534	Mate efflux family protein
AH4AK4_RS09350	COG0307	riboflavin synthase, alpha
AH4AK4_RS09360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AH4AK4_RS09365	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AH4AK4_RS09370	COG0697	spore germination
AH4AK4_RS09375	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AH4AK4_RS09410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AH4AK4_RS09415	COG3099	Belongs to the UPF0263 family
AH4AK4_RS09420	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AH4AK4_RS09425	COG2894	cell division
AH4AK4_RS09430	COG0850	regulation of cytokinetic process
AH4AK4_RS09435	COG3100	YcgL domain-containing protein
AH4AK4_RS09440	COG2951	lytic endotransglycosylase activity
AH4AK4_RS09445	COG1760	l-serine dehydratase
AH4AK4_RS09450	COG1760	l-serine dehydratase
AH4AK4_RS09455	COG3123	guanosine phosphorylase activity
AH4AK4_RS09475	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AH4AK4_RS09480	COG2067	long-chain fatty acid transport protein
AH4AK4_RS09485	COG2067	long-chain fatty acid transport protein
AH4AK4_RS09495	COG1595	DNA-templated transcription, initiation
AH4AK4_RS09505	COG2304	oxidoreductase activity
AH4AK4_RS09525	COG0714	Associated with various cellular activities
AH4AK4_RS09530	COG0183	Belongs to the thiolase family
AH4AK4_RS09535	COG1024	Enoyl-CoA hydratase
AH4AK4_RS09535	COG1250	3-hydroxyacyl-CoA dehydrogenase
AH4AK4_RS09540	COG4681	YaeQ
AH4AK4_RS09565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AH4AK4_RS09585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AH4AK4_RS09595	COG3710	Transcriptional regulator
AH4AK4_RS09595	COG0457	Tetratricopeptide repeat
AH4AK4_RS09600	COG3134	Outer membrane lipoprotein
AH4AK4_RS09605	COG0318	PFAM AMP-dependent synthetase and ligase
AH4AK4_RS09620	COG0140	phosphoribosyl-ATP diphosphatase activity
AH4AK4_RS09620	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AH4AK4_RS09625	COG0107	imidazoleglycerol-phosphate synthase activity
AH4AK4_RS09630	COG2198	Histidine kinase
AH4AK4_RS09630	COG2205	protein histidine kinase activity
AH4AK4_RS09630	COG0784	Response regulator, receiver
AH4AK4_RS09640	COG3437	response regulator, receiver
AH4AK4_RS09645	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AH4AK4_RS09650	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AH4AK4_RS09655	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AH4AK4_RS09655	COG0131	Imidazoleglycerol-phosphate dehydratase
AH4AK4_RS09660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AH4AK4_RS09665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AH4AK4_RS09670	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AH4AK4_RS09680	COG1199	ATP-dependent helicase activity
AH4AK4_RS09685	COG1214	PFAM Peptidase M22, glycoprotease
AH4AK4_RS09695	COG0596	Alpha beta hydrolase
AH4AK4_RS09700	COG0318	PFAM AMP-dependent synthetase and ligase
AH4AK4_RS09715	COG0697	spore germination
AH4AK4_RS09725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AH4AK4_RS09730	COG2832	Protein of unknown function (DUF454)
AH4AK4_RS09735	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AH4AK4_RS09745	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AH4AK4_RS09750	COG1335	isochorismatase
AH4AK4_RS09765	COG3314	Sporulation integral membrane protein YlbJ
AH4AK4_RS09770	COG2197	response regulator
AH4AK4_RS09775	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AH4AK4_RS09775	COG0617	tRNA 3'-terminal CCA addition
AH4AK4_RS09775	COG0517	IMP dehydrogenase activity
AH4AK4_RS09780	COG1643	Atp-dependent helicase
AH4AK4_RS09790	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AH4AK4_RS09805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AH4AK4_RS09810	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AH4AK4_RS09815	COG0709	Synthesizes selenophosphate from selenide and ATP
AH4AK4_RS09830	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AH4AK4_RS09835	COG0840	transmembrane signaling receptor activity
AH4AK4_RS09840	COG1254	Belongs to the acylphosphatase family
AH4AK4_RS09850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AH4AK4_RS09850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AH4AK4_RS09855	COG0489	protein tyrosine kinase activity
AH4AK4_RS09860	COG0572	uridine kinase
AH4AK4_RS09865	COG0717	Belongs to the dCTP deaminase family
AH4AK4_RS09870	COG0306	phosphate transporter
AH4AK4_RS09875	COG1530	ribonuclease E activity
AH4AK4_RS09885	COG0424	maF-like protein
AH4AK4_RS09895	COG1399	metal-binding, possibly nucleic acid-binding protein
AH4AK4_RS09900	COG0416	fatty acid biosynthetic process
AH4AK4_RS09905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AH4AK4_RS09915	COG1028	Short-chain dehydrogenase reductase Sdr
AH4AK4_RS09920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AH4AK4_RS09930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AH4AK4_RS09935	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AH4AK4_RS09940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AH4AK4_RS09945	COG0470	DNA polymerase III
AH4AK4_RS09950	COG0084	hydrolase, TatD family'
AH4AK4_RS09965	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AH4AK4_RS09965	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AH4AK4_RS09970	COG3008	intermembrane lipid transfer
AH4AK4_RS09975	COG2995	paraquat-inducible protein a
AH4AK4_RS09985	COG3141	response to X-ray
AH4AK4_RS09995	COG1067	ATP-dependent peptidase activity
AH4AK4_RS10000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AH4AK4_RS10010	COG0488	(ABC) transporter
AH4AK4_RS10020	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AH4AK4_RS10020	COG0116	Belongs to the methyltransferase superfamily
AH4AK4_RS10030	COG0167	dihydroorotate dehydrogenase activity
AH4AK4_RS10035	COG2902	Dehydrogenase
AH4AK4_RS10045	COG0308	aminopeptidase N
AH4AK4_RS10055	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AH4AK4_RS10060	COG1956	GAF domain-containing protein
AH4AK4_RS10070	COG3278	Belongs to the heme-copper respiratory oxidase family
AH4AK4_RS10085	COG2010	Cytochrome c
AH4AK4_RS10110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AH4AK4_RS10115	COG0589	response to stress
AH4AK4_RS10120	COG0037	tRNA processing
AH4AK4_RS10140	COG1869	D-ribose catabolic process
AH4AK4_RS10145	COG1129	ABC transporter
AH4AK4_RS10150	COG1172	Belongs to the binding-protein-dependent transport system permease family
AH4AK4_RS10155	COG1879	ABC-type sugar transport system periplasmic component
AH4AK4_RS10160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AH4AK4_RS10165	COG1609	Transcriptional regulator
AH4AK4_RS10170	COG5001	Diguanylate cyclase
AH4AK4_RS10170	COG3300	MHYT domain
AH4AK4_RS10195	COG0784	Response regulator, receiver
AH4AK4_RS10195	COG2205	protein histidine kinase activity
AH4AK4_RS10200	COG0776	regulation of translation
AH4AK4_RS10205	COG0072	phenylalanine-tRNA ligase activity
AH4AK4_RS10205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AH4AK4_RS10210	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AH4AK4_RS10215	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AH4AK4_RS10220	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AH4AK4_RS10225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AH4AK4_RS10230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AH4AK4_RS10260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AH4AK4_RS10270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AH4AK4_RS10275	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AH4AK4_RS10280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AH4AK4_RS10285	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AH4AK4_RS10290	COG3313	Fe-S protein
AH4AK4_RS10295	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AH4AK4_RS10295	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AH4AK4_RS10295	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AH4AK4_RS10300	COG1105	Belongs to the carbohydrate kinase PfkB family
AH4AK4_RS10305	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AH4AK4_RS10305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AH4AK4_RS10310	COG1609	Transcriptional regulator
AH4AK4_RS10315	COG0814	amino acid
AH4AK4_RS10325	COG5654	RES domain protein
AH4AK4_RS10340	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AH4AK4_RS10345	COG0513	Belongs to the DEAD box helicase family
AH4AK4_RS10355	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AH4AK4_RS10360	COG2890	protein-(glutamine-N5) methyltransferase activity
AH4AK4_RS10365	COG2840	Smr protein MutS2
AH4AK4_RS10400	COG2824	Alkylphosphonate utilization operon protein PhnA
AH4AK4_RS10405	COG1280	lysine exporter protein (LysE YggA)
AH4AK4_RS10450	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AH4AK4_RS10455	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AH4AK4_RS10465	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AH4AK4_RS10470	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AH4AK4_RS10480	COG0205	6-phosphofructokinase activity
AH4AK4_RS10485	COG1473	amidohydrolase
AH4AK4_RS10490	COG1011	Hydrolase
AH4AK4_RS10495	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AH4AK4_RS10520	COG3593	DNA synthesis involved in DNA repair
AH4AK4_RS10535	COG0583	DNA-binding transcription factor activity
AH4AK4_RS10540	COG0730	response to heat
AH4AK4_RS10545	COG3148	PFAM DTW domain containing protein
AH4AK4_RS10555	COG1181	Belongs to the D-alanine--D-alanine ligase family
AH4AK4_RS10565	COG0386	Belongs to the glutathione peroxidase family
AH4AK4_RS10570	COG0513	Belongs to the DEAD box helicase family
AH4AK4_RS10585	COG1742	UPF0060 membrane protein
AH4AK4_RS10610	COG2329	Antibiotic biosynthesis monooxygenase
AH4AK4_RS10615	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AH4AK4_RS10645	COG2501	S4 domain
AH4AK4_RS10660	COG1132	(ABC) transporter
AH4AK4_RS10665	COG1132	(ABC) transporter
AH4AK4_RS10675	COG3118	belongs to the thioredoxin family
AH4AK4_RS10680	COG0471	metal ion transport
AH4AK4_RS10690	COG0058	SHG alpha-glucan phosphorylase activity
AH4AK4_RS10720	COG0814	amino acid
AH4AK4_RS10725	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AH4AK4_RS10730	COG0514	ATP-dependent DNA helicase (RecQ)
AH4AK4_RS10740	COG2766	serine protein kinase
AH4AK4_RS10745	COG2718	Belongs to the UPF0229 family
AH4AK4_RS10750	COG2719	SpoVR family
AH4AK4_RS10760	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AH4AK4_RS10765	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AH4AK4_RS10770	COG0586	Pfam SNARE associated Golgi protein
AH4AK4_RS10780	COG0556	nucleotide-excision repair
AH4AK4_RS10795	COG2985	domain, Protein
AH4AK4_RS10795	COG0569	domain protein
AH4AK4_RS10800	COG0741	lytic transglycosylase activity
AH4AK4_RS10800	COG0739	heme binding
AH4AK4_RS10800	COG1196	nuclear chromosome segregation
AH4AK4_RS10820	COG4565	transcriptional regulatory protein
AH4AK4_RS10825	COG3290	protein histidine kinase activity
AH4AK4_RS10830	COG1846	Transcriptional regulator
AH4AK4_RS10830	COG1940	carbohydrate kinase activity
AH4AK4_RS10840	COG3012	SEC-C Motif Domain Protein
AH4AK4_RS10845	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AH4AK4_RS10850	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AH4AK4_RS10855	COG0247	lactate metabolic process
AH4AK4_RS10870	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AH4AK4_RS10875	COG0437	4 iron, 4 sulfur cluster binding
AH4AK4_RS10880	COG3301	Polysulphide reductase, NrfD
AH4AK4_RS10885	COG1138	Cytochrome C-type biogenesis protein
AH4AK4_RS10895	COG3088	subunit of a heme lyase
AH4AK4_RS10895	COG4235	cytochrome complex assembly
AH4AK4_RS10900	COG1051	belongs to the nudix hydrolase family
AH4AK4_RS10910	COG3046	protein related to deoxyribodipyrimidine photolyase
AH4AK4_RS10915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AH4AK4_RS10930	COG0517	IMP dehydrogenase activity
AH4AK4_RS10930	COG0516	GMP reductase activity
AH4AK4_RS10940	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AH4AK4_RS10945	COG0583	DNA-binding transcription factor activity
AH4AK4_RS10960	COG3706	GGDEF domain
AH4AK4_RS10965	COG4977	sequence-specific DNA binding
AH4AK4_RS10965	COG1917	Cupin 2, conserved barrel domain protein
AH4AK4_RS10980	COG2910	NAD(P)H-binding
AH4AK4_RS10990	COG0626	cystathionine gamma-synthase activity
AH4AK4_RS10995	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AH4AK4_RS11015	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AH4AK4_RS11035	COG1435	thymidine kinase activity
AH4AK4_RS11040	COG1757	Na H antiporter
AH4AK4_RS11045	COG2916	Histone family protein nucleoid-structuring protein H-NS
AH4AK4_RS11050	COG2096	Adenosyltransferase
AH4AK4_RS11055	COG3530	Putative quorum-sensing-regulated virulence factor
AH4AK4_RS11060	COG0602	queuosine metabolic process
AH4AK4_RS11065	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AH4AK4_RS11085	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AH4AK4_RS11095	COG0776	regulation of translation
AH4AK4_RS11100	COG0539	negative regulation of cytoplasmic translation
AH4AK4_RS11105	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AH4AK4_RS11110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AH4AK4_RS11135	COG0778	Nitroreductase
AH4AK4_RS11140	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AH4AK4_RS11145	COG5001	Diguanylate cyclase
AH4AK4_RS11145	COG3300	MHYT domain
AH4AK4_RS11155	COG0583	DNA-binding transcription factor activity
AH4AK4_RS11160	COG0745	RESPONSE REGULATOR receiver
AH4AK4_RS11185	COG4989	oxidoreductase activity
AH4AK4_RS11190	COG0724	RNA recognition motif
AH4AK4_RS11210	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AH4AK4_RS11225	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AH4AK4_RS11230	COG1360	Flagellar Motor Protein
AH4AK4_RS11235	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AH4AK4_RS11240	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AH4AK4_RS11245	COG0649	NAD binding
AH4AK4_RS11245	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AH4AK4_RS11260	COG1034	ATP synthesis coupled electron transport
AH4AK4_RS11265	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AH4AK4_RS11270	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AH4AK4_RS11275	COG0839	Belongs to the complex I subunit 6 family
AH4AK4_RS11280	COG0713	ATP synthesis coupled electron transport
AH4AK4_RS11290	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AH4AK4_RS11295	COG1007	ATP synthesis coupled electron transport
AH4AK4_RS11300	COG0047	phosphoribosylformylglycinamidine synthase activity
AH4AK4_RS11300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AH4AK4_RS11305	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AH4AK4_RS11310	COG1645	bacterial-type flagellum-dependent swarming motility
AH4AK4_RS11315	COG1160	GTP binding
AH4AK4_RS11320	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AH4AK4_RS11325	COG2976	Protein conserved in bacteria
AH4AK4_RS11330	COG0124	histidyl-tRNA synthetase
AH4AK4_RS11335	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AH4AK4_RS11340	COG1426	Protein conserved in bacteria
AH4AK4_RS11350	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AH4AK4_RS11355	COG0105	UTP biosynthetic process
AH4AK4_RS11360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AH4AK4_RS11370	COG0633	Ferredoxin
AH4AK4_RS11375	COG0443	Heat shock 70 kDa protein
AH4AK4_RS11380	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AH4AK4_RS11390	COG0822	iron-sulfur transferase activity
AH4AK4_RS11395	COG1104	cysteine desulfurase activity
AH4AK4_RS11415	COG3154	lipid carrier protein
AH4AK4_RS11420	COG0826	peptidase U32
AH4AK4_RS11425	COG0826	peptidase U32
AH4AK4_RS11440	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AH4AK4_RS11445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AH4AK4_RS11450	COG1862	Preprotein translocase
AH4AK4_RS11455	COG0343	queuine tRNA-ribosyltransferase activity
AH4AK4_RS11460	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AH4AK4_RS11465	COG0517	IMP dehydrogenase activity
AH4AK4_RS11475	COG3634	alkyl hydroperoxide reductase activity
AH4AK4_RS11510	COG1280	lysine exporter protein (LysE YggA)
AH4AK4_RS11515	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AH4AK4_RS11520	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AH4AK4_RS11520	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AH4AK4_RS11525	COG0509	glycine decarboxylation via glycine cleavage system
AH4AK4_RS11530	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AH4AK4_RS11535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AH4AK4_RS11540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AH4AK4_RS11555	COG1609	Transcriptional regulator
AH4AK4_RS11560	COG1129	ABC transporter
AH4AK4_RS11565	COG1172	Belongs to the binding-protein-dependent transport system permease family
AH4AK4_RS11570	COG1879	ABC-type sugar transport system periplasmic component
AH4AK4_RS11580	COG0673	inositol 2-dehydrogenase activity
AH4AK4_RS11585	COG2814	Major facilitator Superfamily
AH4AK4_RS11590	COG0444	Belongs to the ABC transporter superfamily
AH4AK4_RS11595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AH4AK4_RS11600	COG0601	transmembrane transport
AH4AK4_RS11610	COG0625	glutathione transferase activity
AH4AK4_RS11625	COG0483	inositol monophosphate 1-phosphatase activity
AH4AK4_RS11640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AH4AK4_RS11645	COG2056	Na+-H+ antiporter family
AH4AK4_RS11650	COG2814	Major facilitator Superfamily
AH4AK4_RS11655	COG0583	DNA-binding transcription factor activity
AH4AK4_RS11660	COG0513	Belongs to the DEAD box helicase family
AH4AK4_RS11665	COG2050	protein possibly involved in aromatic compounds catabolism
AH4AK4_RS11675	COG0277	FAD linked oxidase domain protein
AH4AK4_RS11675	COG0247	lactate metabolic process
AH4AK4_RS11690	COG1253	flavin adenine dinucleotide binding
AH4AK4_RS11695	COG1902	pentaerythritol trinitrate reductase activity
AH4AK4_RS11705	COG0647	UMP catabolic process
AH4AK4_RS11715	COG0367	asparagine synthase
AH4AK4_RS11725	COG0625	glutathione transferase activity
AH4AK4_RS11735	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AH4AK4_RS11750	COG0564	pseudouridine synthase activity
AH4AK4_RS11755	COG3706	GGDEF domain
AH4AK4_RS11760	COG0840	transmembrane signaling receptor activity
AH4AK4_RS11765	COG0318	PFAM AMP-dependent synthetase and ligase
AH4AK4_RS11775	COG2207	Transcriptional regulator
AH4AK4_RS11810	COG2855	membrane
AH4AK4_RS11820	COG2814	Major facilitator Superfamily
AH4AK4_RS11825	COG3246	L-lysine catabolic process to acetate
AH4AK4_RS11830	COG2175	clavaminate synthase activity
AH4AK4_RS11840	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AH4AK4_RS11865	COG5492	domain, Protein
AH4AK4_RS11865	COG4932	domain protein
AH4AK4_RS11880	COG3188	usher protein
AH4AK4_RS11895	COG3539	Fimbrial protein
AH4AK4_RS11910	COG0670	Belongs to the BI1 family
AH4AK4_RS11915	COG1289	transmembrane transporter activity
AH4AK4_RS11920	COG2920	part of a sulfur-relay system
AH4AK4_RS11925	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AH4AK4_RS11930	COG0285	dihydrofolate synthase activity
AH4AK4_RS11935	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AH4AK4_RS11940	COG0101	tRNA pseudouridine synthase activity
AH4AK4_RS11950	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AH4AK4_RS11955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AH4AK4_RS11960	COG0671	phosphoesterase, PA-phosphatase related
AH4AK4_RS11965	COG1464	Belongs to the NlpA lipoprotein family
AH4AK4_RS11985	COG1119	ATPase activity
AH4AK4_RS12005	COG0574	Belongs to the PEP-utilizing enzyme family
AH4AK4_RS12005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AH4AK4_RS12010	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AH4AK4_RS12020	COG1113	amino acid transport
AH4AK4_RS12065	COG1242	4 iron, 4 sulfur cluster binding
AH4AK4_RS12070	COG0067	glutamate synthase
AH4AK4_RS12070	COG0069	glutamate synthase activity
AH4AK4_RS12070	COG0070	glutamate synthase
AH4AK4_RS12075	COG0493	'glutamate synthase
AH4AK4_RS12080	COG1126	abc transporter atp-binding protein
AH4AK4_RS12085	COG0765	amino acid transport
AH4AK4_RS12090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_RS12095	COG0789	Transcriptional regulator
AH4AK4_RS12110	COG4104	PAAR repeat-containing protein
AH4AK4_RS12120	COG0513	Belongs to the DEAD box helicase family
AH4AK4_RS12150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AH4AK4_RS12155	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AH4AK4_RS12160	COG0505	Belongs to the CarA family
AH4AK4_RS12165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AH4AK4_RS12175	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AH4AK4_RS12180	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AH4AK4_RS12185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AH4AK4_RS12190	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AH4AK4_RS12195	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AH4AK4_RS12200	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AH4AK4_RS12205	COG4139	cobalamin transport
AH4AK4_RS12245	COG0023	Translation Initiation Factor
AH4AK4_RS12250	COG2119	membrane
AH4AK4_RS12285	COG2203	Gaf domain
AH4AK4_RS12285	COG2199	diguanylate cyclase activity
AH4AK4_RS12305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AH4AK4_RS12315	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AH4AK4_RS12320	COG2261	transglycosylase associated protein
AH4AK4_RS12325	COG0625	glutathione transferase activity
AH4AK4_RS12345	COG4974	Belongs to the 'phage' integrase family
AH4AK4_RS12440	COG4695	Portal protein
AH4AK4_RS12630	COG0322	excinuclease ABC activity
AH4AK4_RS12635	COG2197	response regulator
AH4AK4_RS12640	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AH4AK4_RS12645	COG2835	tetraacyldisaccharide 4'-kinase activity
AH4AK4_RS12650	COG1663	tetraacyldisaccharide 4'-kinase activity
AH4AK4_RS12655	COG1132	(ABC) transporter
AH4AK4_RS12660	COG0658	competence protein
AH4AK4_RS12660	COG2333	competence protein COMEC
AH4AK4_RS12675	COG0433	COG0433 Predicted ATPase
AH4AK4_RS12680	COG1448	Aminotransferase
AH4AK4_RS12695	COG1199	ATP-dependent helicase activity
AH4AK4_RS12705	COG0123	including yeast histone deacetylase and acetoin utilization protein
AH4AK4_RS12710	COG0477	Major facilitator Superfamily
AH4AK4_RS12715	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AH4AK4_RS12720	COG1785	Belongs to the alkaline phosphatase family
AH4AK4_RS12740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AH4AK4_RS12745	COG2197	response regulator
AH4AK4_RS12765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_RS12770	COG0765	amino acid transport
AH4AK4_RS12775	COG1126	abc transporter atp-binding protein
AH4AK4_RS12790	COG0531	amino acid
AH4AK4_RS12805	COG1253	flavin adenine dinucleotide binding
AH4AK4_RS12815	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AH4AK4_RS12820	COG0581	inorganic phosphate transmembrane transporter activity
AH4AK4_RS12825	COG0573	inorganic phosphate transmembrane transporter activity
AH4AK4_RS12830	COG0590	tRNA wobble adenosine to inosine editing
AH4AK4_RS12845	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AH4AK4_RS12865	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AH4AK4_RS12870	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AH4AK4_RS12875	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AH4AK4_RS12880	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AH4AK4_RS12905	COG2716	regulation of RNA biosynthetic process
AH4AK4_RS12910	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AH4AK4_RS12920	COG2239	Acts as a magnesium transporter
AH4AK4_RS12935	COG1705	Flagellar rod assembly protein muramidase FlgJ
AH4AK4_RS12935	COG3951	Flagellar rod assembly protein muramidase FlgJ
AH4AK4_RS12940	COG1706	bacterial-type flagellum-dependent cell motility
AH4AK4_RS12945	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AH4AK4_RS12960	COG1749	Flagellar hook protein flgE
AH4AK4_RS12975	COG1815	bacterial-type flagellum-dependent cell motility
AH4AK4_RS12980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AH4AK4_RS12985	COG0835	chemotaxis
AH4AK4_RS12985	COG0784	Response regulator, receiver
AH4AK4_RS12990	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
AH4AK4_RS13005	COG0622	Phosphoesterase
AH4AK4_RS13010	COG4166	transmembrane transport
AH4AK4_RS13020	COG1187	pseudouridine synthase activity
AH4AK4_RS13035	COG0697	spore germination
AH4AK4_RS13065	COG1278	Cold shock
AH4AK4_RS13105	COG3132	Protein of unknown function, DUF480
AH4AK4_RS13140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AH4AK4_RS13155	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AH4AK4_RS13160	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AH4AK4_RS13180	COG0837	glucose binding
AH4AK4_RS13185	COG1737	Transcriptional regulator
AH4AK4_RS13190	COG0469	pyruvate kinase activity
AH4AK4_RS13200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AH4AK4_RS13205	COG1960	acyl-CoA dehydrogenase activity
AH4AK4_RS13215	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AH4AK4_RS13270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AH4AK4_RS13295	COG1061	Type III restriction enzyme res subunit
AH4AK4_RS13305	COG2003	Belongs to the UPF0758 family
AH4AK4_RS13345	COG2003	Belongs to the UPF0758 family
AH4AK4_RS13365	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AH4AK4_RS13375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AH4AK4_RS13380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AH4AK4_RS13385	COG1309	transcriptional regulator
AH4AK4_RS13400	COG1946	Acyl-CoA thioesterase
AH4AK4_RS13410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AH4AK4_RS13420	COG0009	L-threonylcarbamoyladenylate synthase
AH4AK4_RS13425	COG0613	PHP domain protein
AH4AK4_RS13430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AH4AK4_RS13435	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AH4AK4_RS13435	COG0512	Glutamine amidotransferase of anthranilate synthase
AH4AK4_RS13440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AH4AK4_RS13445	COG0135	phosphoribosylanthranilate isomerase activity
AH4AK4_RS13445	COG0134	indole-3-glycerol-phosphate synthase activity
AH4AK4_RS13450	COG0133	tryptophan synthase activity
AH4AK4_RS13455	COG0159	tryptophan synthase activity
AH4AK4_RS13470	COG1988	membrane-bound metal-dependent
AH4AK4_RS13490	COG0583	DNA-binding transcription factor activity
AH4AK4_RS13500	COG4521	taurine ABC transporter
AH4AK4_RS13505	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AH4AK4_RS13510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AH4AK4_RS13515	COG2175	clavaminate synthase activity
AH4AK4_RS13520	COG5507	3-demethylubiquinone-9 3-methyltransferase
AH4AK4_RS13525	COG2814	Major facilitator Superfamily
AH4AK4_RS13530	COG0109	protoheme IX farnesyltransferase activity
AH4AK4_RS13535	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AH4AK4_RS13540	COG1845	cytochrome c oxidase, subunit III
AH4AK4_RS13545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AH4AK4_RS13550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AH4AK4_RS13555	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AH4AK4_RS13560	COG0583	DNA-binding transcription factor activity
AH4AK4_RS13610	COG0708	Exodeoxyribonuclease III
AH4AK4_RS13620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AH4AK4_RS13625	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AH4AK4_RS13640	COG0095	Lipoate-protein ligase
AH4AK4_RS13650	COG1136	(ABC) transporter
AH4AK4_RS13650	COG0577	efflux transmembrane transporter activity
AH4AK4_RS13655	COG0577	efflux transmembrane transporter activity
AH4AK4_RS13655	COG1136	(ABC) transporter
AH4AK4_RS13660	COG1136	(ABC) transporter
AH4AK4_RS13660	COG0577	efflux transmembrane transporter activity
AH4AK4_RS13680	COG0640	Transcriptional regulator
AH4AK4_RS13690	COG1285	pathogenesis
AH4AK4_RS13720	COG0484	heat shock protein binding
AH4AK4_RS13725	COG0443	Heat shock 70 kDa protein
AH4AK4_RS13730	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AH4AK4_RS13735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AH4AK4_RS13740	COG3706	GGDEF domain
AH4AK4_RS13745	COG0497	DNA recombination
AH4AK4_RS13750	COG1227	inorganic diphosphatase activity
AH4AK4_RS13760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AH4AK4_RS13765	COG0577	efflux transmembrane transporter activity
AH4AK4_RS13765	COG1136	(ABC) transporter
AH4AK4_RS13775	COG2375	cellular response to nickel ion
AH4AK4_RS13780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AH4AK4_RS13785	COG2916	Histone family protein nucleoid-structuring protein H-NS
AH4AK4_RS13790	COG0583	DNA-binding transcription factor activity
AH4AK4_RS13795	COG2610	gluconate transmembrane transporter activity
AH4AK4_RS13800	COG3048	D-serine ammonia-lyase activity
AH4AK4_RS13805	COG0538	isocitrate dehydrogenase activity
AH4AK4_RS13810	COG2207	Transcriptional regulator
AH4AK4_RS13815	COG1482	cell wall glycoprotein biosynthetic process
AH4AK4_RS13825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AH4AK4_RS13840	COG5492	domain, Protein
AH4AK4_RS13840	COG4932	domain protein
AH4AK4_RS13855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AH4AK4_RS13855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AH4AK4_RS13855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AH4AK4_RS13865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AH4AK4_RS13870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AH4AK4_RS13870	COG3711	transcriptional antiterminator
AH4AK4_RS13875	COG1187	pseudouridine synthase activity
AH4AK4_RS13885	COG0482	sulfurtransferase activity
AH4AK4_RS13890	COG2915	High frequency lysogenization protein hflD homolog
AH4AK4_RS13895	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AH4AK4_RS13900	COG2850	peptidyl-arginine hydroxylation
AH4AK4_RS13905	COG0469	pyruvate kinase activity
AH4AK4_RS13910	COG1196	nuclear chromosome segregation
AH4AK4_RS13910	COG3264	Mechanosensitive ion channel
AH4AK4_RS13920	COG2706	6-phosphogluconolactonase activity
AH4AK4_RS13945	COG0281	malic enzyme
AH4AK4_RS13950	COG0746	molybdenum cofactor guanylyltransferase activity
AH4AK4_RS13955	COG1763	Mo-molybdopterin cofactor biosynthetic process
AH4AK4_RS13960	COG1289	transmembrane transporter activity
AH4AK4_RS13965	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AH4AK4_RS13995	COG3220	belongs to the UPF0276 family
AH4AK4_RS14010	COG0454	-acetyltransferase
AH4AK4_RS14015	COG1396	sequence-specific DNA binding
AH4AK4_RS14025	COG4319	ketosteroid isomerase
AH4AK4_RS14030	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AH4AK4_RS14035	COG0083	homoserine kinase activity
AH4AK4_RS14045	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AH4AK4_RS14050	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AH4AK4_RS14065	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AH4AK4_RS14075	COG0745	RESPONSE REGULATOR receiver
AH4AK4_RS14090	COG4988	ABC transporter
AH4AK4_RS14095	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AH4AK4_RS14115	COG1720	tRNA m6t6A37 methyltransferase activity
AH4AK4_RS14130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AH4AK4_RS14135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AH4AK4_RS14140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AH4AK4_RS14150	COG2190	(PTS) system
AH4AK4_RS14155	COG3038	cytochrome b561
AH4AK4_RS14160	COG0419	ATPase involved in DNA repair
AH4AK4_RS14165	COG0420	3'-5' exonuclease activity
AH4AK4_RS14170	COG0456	acetyltransferase
AH4AK4_RS14175	COG2974	May be involved in recombination
AH4AK4_RS14185	COG0405	Gamma-glutamyltransferase
AH4AK4_RS14190	COG4651	solute:proton antiporter activity
AH4AK4_RS14190	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AH4AK4_RS14225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AH4AK4_RS14230	COG1917	Cupin 2, conserved barrel domain protein
AH4AK4_RS14230	COG1396	sequence-specific DNA binding
AH4AK4_RS14245	COG0531	amino acid
AH4AK4_RS14250	COG0531	amino acid
AH4AK4_RS14260	COG1283	sodium-dependent phosphate transmembrane transporter activity
AH4AK4_RS14270	COG3384	dioxygenase
AH4AK4_RS14275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_RS14275	COG2205	protein histidine kinase activity
AH4AK4_RS14305	COG2205	protein histidine kinase activity
AH4AK4_RS14305	COG0784	Response regulator, receiver
AH4AK4_RS14335	COG3158	transport of potassium into the cell
AH4AK4_RS14345	COG1388	LysM domain
AH4AK4_RS14345	COG1376	ErfK ybiS ycfS ynhG family protein
AH4AK4_RS14360	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AH4AK4_RS14365	COG0791	NLP P60 protein
AH4AK4_RS14375	COG3118	belongs to the thioredoxin family
AH4AK4_RS14385	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AH4AK4_RS14390	COG0788	formyltetrahydrofolate deformylase activity
AH4AK4_RS14415	COG0739	heme binding
AH4AK4_RS14415	COG0741	lytic transglycosylase activity
AH4AK4_RS14415	COG1196	nuclear chromosome segregation
AH4AK4_RS14420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AH4AK4_RS14425	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AH4AK4_RS14430	COG0673	inositol 2-dehydrogenase activity
AH4AK4_RS14465	COG1032	radical SAM domain protein
AH4AK4_RS14475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AH4AK4_RS14485	COG3706	GGDEF domain
AH4AK4_RS14490	COG1752	Esterase of the alpha-beta hydrolase superfamily
AH4AK4_RS14495	COG0733	neurotransmitter:sodium symporter activity
AH4AK4_RS14525	COG0281	malic enzyme
AH4AK4_RS14530	COG2207	Transcriptional regulator
AH4AK4_RS14535	COG0534	Mate efflux family protein
AH4AK4_RS14550	COG2233	PERMEase
AH4AK4_RS14555	COG0095	Lipoate-protein ligase
AH4AK4_RS14560	COG1115	amino acid carrier protein
AH4AK4_RS14565	COG0019	diaminopimelate decarboxylase activity
AH4AK4_RS14575	COG0678	peroxiredoxin activity
AH4AK4_RS14580	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AH4AK4_RS14590	COG1126	abc transporter atp-binding protein
AH4AK4_RS14595	COG0765	amino acid transport
AH4AK4_RS14600	COG4597	amino acid ABC transporter
AH4AK4_RS14605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_RS14620	COG1131	(ABC) transporter
AH4AK4_RS14625	COG0545	Peptidyl-prolyl cis-trans isomerase
AH4AK4_RS14635	COG1940	carbohydrate kinase activity
AH4AK4_RS14645	COG4783	chaperone-mediated protein folding
AH4AK4_RS14655	COG5002	protein histidine kinase activity
AH4AK4_RS14660	COG0745	RESPONSE REGULATOR receiver
AH4AK4_RS14665	COG0346	lactoylglutathione lyase activity
AH4AK4_RS14670	COG3706	GGDEF domain
AH4AK4_RS14675	COG3284	Transcriptional regulator
AH4AK4_RS14690	COG0697	spore germination
AH4AK4_RS14700	COG3290	protein histidine kinase activity
AH4AK4_RS14705	COG0281	malic enzyme
AH4AK4_RS14715	COG1846	Transcriptional regulator
AH4AK4_RS14720	COG1566	PFAM secretion protein HlyD family protein
AH4AK4_RS14745	COG0602	queuosine metabolic process
AH4AK4_RS14760	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AH4AK4_RS14770	COG1196	nuclear chromosome segregation
AH4AK4_RS14780	COG2860	membrane
AH4AK4_RS14790	COG3108	Peptidase M15
AH4AK4_RS14795	COG2989	Protein conserved in bacteria
AH4AK4_RS14810	COG0463	Glycosyl transferase, family 2
AH4AK4_RS14825	COG0366	Alpha amylase catalytic
AH4AK4_RS14865	COG3706	GGDEF domain
AH4AK4_RS14870	COG0037	tRNA processing
AH4AK4_RS14875	COG3590	peptidase
AH4AK4_RS14885	COG0488	(ABC) transporter
AH4AK4_RS14895	COG0531	amino acid
AH4AK4_RS14900	COG0814	amino acid
AH4AK4_RS14905	COG0583	DNA-binding transcription factor activity
AH4AK4_RS14915	COG3459	Glycosyltransferase 36 associated
AH4AK4_RS14930	COG2823	Periplasmic or secreted lipoprotein
AH4AK4_RS14935	COG0825	malonyl-CoA metabolic process
AH4AK4_RS14945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AH4AK4_RS14950	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AH4AK4_RS14955	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AH4AK4_RS14960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AH4AK4_RS14965	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AH4AK4_RS14980	COG0750	zinc metalloprotease
AH4AK4_RS14985	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AH4AK4_RS14990	COG0575	Belongs to the CDS family
AH4AK4_RS14995	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AH4AK4_RS15000	COG0233	cytoplasmic translational termination
AH4AK4_RS15005	COG0528	UMP kinase activity
AH4AK4_RS15010	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AH4AK4_RS15015	COG0052	Belongs to the universal ribosomal protein uS2 family
AH4AK4_RS15020	COG0024	Methionine aminopeptidase
AH4AK4_RS15025	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AH4AK4_RS15030	COG2171	N-acyltransferase activity
AH4AK4_RS15040	COG1263	PTS System
AH4AK4_RS15040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AH4AK4_RS15050	COG4580	involved in the transport of maltose and maltodextrins
AH4AK4_RS15060	COG0564	pseudouridine synthase activity
AH4AK4_RS15065	COG3098	single-species biofilm formation
AH4AK4_RS15090	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AH4AK4_RS15100	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AH4AK4_RS15100	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AH4AK4_RS15115	COG1611	Belongs to the LOG family
AH4AK4_RS15120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AH4AK4_RS15125	COG0473	3-isopropylmalate dehydrogenase activity
AH4AK4_RS15135	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AH4AK4_RS15140	COG2363	Small membrane protein
AH4AK4_RS15150	COG0583	DNA-binding transcription factor activity
AH4AK4_RS15155	COG0840	transmembrane signaling receptor activity
AH4AK4_RS15160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AH4AK4_RS15175	COG1477	protein flavinylation
AH4AK4_RS15180	COG2871	sodium ion transport
AH4AK4_RS15185	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AH4AK4_RS15190	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AH4AK4_RS15195	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AH4AK4_RS15200	COG1805	sodium ion transport
AH4AK4_RS15205	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AH4AK4_RS15210	COG0271	Belongs to the BolA IbaG family
AH4AK4_RS15215	COG2813	Specifically methylates the guanine in position
AH4AK4_RS15225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AH4AK4_RS15235	COG2211	Major facilitator Superfamily
AH4AK4_RS15240	COG3248	Nucleoside-binding outer membrane protein
AH4AK4_RS15245	COG1666	GTP binding
AH4AK4_RS15250	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AH4AK4_RS15295	COG4104	PAAR repeat-containing protein
AH4AK4_RS15310	COG2771	luxR family
AH4AK4_RS15320	COG2072	flavoprotein involved in K transport
AH4AK4_RS15325	COG1393	Belongs to the ArsC family
AH4AK4_RS15330	COG0798	PFAM Bile acid sodium symporter
AH4AK4_RS15340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AH4AK4_RS15375	COG5000	phosphorelay sensor kinase activity
AH4AK4_RS15375	COG5002	protein histidine kinase activity
AH4AK4_RS15380	COG0745	RESPONSE REGULATOR receiver
AH4AK4_RS15385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AH4AK4_RS15390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AH4AK4_RS15400	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AH4AK4_RS15400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AH4AK4_RS15405	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AH4AK4_RS15410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AH4AK4_RS15415	COG1151	hydroxylamine reductase activity
AH4AK4_RS15420	COG0783	Belongs to the Dps family
AH4AK4_RS15445	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AH4AK4_RS15460	COG0300	oxidoreductase activity
AH4AK4_RS15475	COG0789	Transcriptional regulator
AH4AK4_RS15480	COG3272	Protein of unknown function (DUF1722)
AH4AK4_RS15505	COG1605	Chorismate mutase
AH4AK4_RS15505	COG0077	Prephenate dehydratase
AH4AK4_RS15535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AH4AK4_RS15550	COG0457	Tetratricopeptide repeat
AH4AK4_RS15575	COG2133	pyrroloquinoline quinone binding
AH4AK4_RS15580	COG1349	DNA-binding transcription factor activity
AH4AK4_RS15585	COG2084	Dehydrogenase
AH4AK4_RS15595	COG0235	Class ii aldolase
AH4AK4_RS15600	COG3622	Belongs to the hyi family
AH4AK4_RS15605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AH4AK4_RS15610	COG2610	gluconate transmembrane transporter activity
AH4AK4_RS15620	COG0840	transmembrane signaling receptor activity
AH4AK4_RS15630	COG0300	oxidoreductase activity
AH4AK4_RS15650	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AH4AK4_RS15670	COG3813	Protein conserved in bacteria
AH4AK4_RS15680	COG0826	peptidase U32
AH4AK4_RS15690	COG1280	lysine exporter protein (LysE YggA)
AH4AK4_RS15700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AH4AK4_RS15725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_RS15725	COG2205	protein histidine kinase activity
AH4AK4_RS15730	COG2197	response regulator
AH4AK4_RS15740	COG3188	usher protein
AH4AK4_RS15755	COG2203	Gaf domain
AH4AK4_RS15755	COG2200	EAL domain
AH4AK4_RS15755	COG2199	diguanylate cyclase activity
AH4AK4_RS15795	COG0114	fumarate hydratase activity
AH4AK4_RS15805	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AH4AK4_RS15805	COG0506	proline dehydrogenase activity
AH4AK4_RS15805	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AH4AK4_RS15810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AH4AK4_RS15825	COG0737	Belongs to the 5'-nucleotidase family
AH4AK4_RS15845	COG2204	response regulator
AH4AK4_RS15850	COG0545	Peptidyl-prolyl cis-trans isomerase
AH4AK4_RS15865	COG1047	Peptidyl-prolyl cis-trans
AH4AK4_RS15870	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AH4AK4_RS15880	COG0835	chemotaxis
AH4AK4_RS15880	COG0784	Response regulator, receiver
AH4AK4_RS15885	COG0429	hydrolase of the alpha beta-hydrolase fold
AH4AK4_RS15890	COG2203	Gaf domain
AH4AK4_RS15890	COG3706	GGDEF domain
AH4AK4_RS15890	COG5001	Diguanylate cyclase
AH4AK4_RS15890	COG4251	negative regulation of phosphorylation
AH4AK4_RS15895	COG3089	Belongs to the UPF0270 family
AH4AK4_RS15900	COG3954	Phosphoribulokinase
AH4AK4_RS15915	COG1765	OsmC-like protein
AH4AK4_RS15945	COG2205	protein histidine kinase activity
AH4AK4_RS15950	COG2814	Major facilitator Superfamily
AH4AK4_RS15975	COG0748	coenzyme F420 binding
AH4AK4_RS15980	COG3721	Heme iron utilization protein
AH4AK4_RS15990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AH4AK4_RS16015	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AH4AK4_RS16025	COG0463	Glycosyl transferase, family 2
AH4AK4_RS16030	COG0741	lytic transglycosylase activity
AH4AK4_RS16035	COG0488	(ABC) transporter
AH4AK4_RS16045	COG2252	PERMEase
AH4AK4_RS16050	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AH4AK4_RS16055	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AH4AK4_RS16060	COG3178	'Phosphotransferase
AH4AK4_RS16065	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AH4AK4_RS16075	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AH4AK4_RS16080	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AH4AK4_RS16085	COG2967	ApaG domain
AH4AK4_RS16090	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AH4AK4_RS16105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AH4AK4_RS16110	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AH4AK4_RS16115	COG3314	Sporulation integral membrane protein YlbJ
AH4AK4_RS16120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AH4AK4_RS16125	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AH4AK4_RS16135	COG0142	geranyltranstransferase activity
AH4AK4_RS16140	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AH4AK4_RS16145	COG0330	HflC and HflK could
AH4AK4_RS16150	COG0330	HflC and HflK could
AH4AK4_RS16155	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AH4AK4_RS16160	COG1923	regulation of RNA biosynthetic process
AH4AK4_RS16165	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AH4AK4_RS16170	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AH4AK4_RS16180	COG0802	atpase or kinase
AH4AK4_RS16185	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AH4AK4_RS16185	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AH4AK4_RS16205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AH4AK4_RS16210	COG2011	ABC-type metal ion transport system permease component
AH4AK4_RS16215	COG1464	Belongs to the NlpA lipoprotein family
AH4AK4_RS16225	COG0840	transmembrane signaling receptor activity
AH4AK4_RS16235	COG2205	protein histidine kinase activity
AH4AK4_RS16235	COG0784	Response regulator, receiver
AH4AK4_RS16245	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AH4AK4_RS16250	COG5002	protein histidine kinase activity
AH4AK4_RS16250	COG2198	Histidine kinase
AH4AK4_RS16250	COG0784	Response regulator, receiver
AH4AK4_RS16285	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AH4AK4_RS16290	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AH4AK4_RS16300	COG2716	regulation of RNA biosynthetic process
AH4AK4_RS16305	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AH4AK4_RS16310	COG3013	Belongs to the UPF0304 family
AH4AK4_RS16320	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AH4AK4_RS16325	COG0857	belongs to the CobB CobQ family
AH4AK4_RS16325	COG0280	phosphate acetyltransferase
AH4AK4_RS16330	COG0440	acetolactate synthase activity
AH4AK4_RS16335	COG0028	Belongs to the TPP enzyme family
AH4AK4_RS16340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AH4AK4_RS16345	COG0671	phosphoesterase, PA-phosphatase related
AH4AK4_RS16355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AH4AK4_RS16360	COG0473	3-isopropylmalate dehydrogenase activity
AH4AK4_RS16365	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AH4AK4_RS16370	COG0066	3-isopropylmalate dehydratase activity
AH4AK4_RS16385	COG4143	(ABC) transporter
AH4AK4_RS16390	COG1178	ABC-type Fe3 transport system permease component
AH4AK4_RS16395	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AH4AK4_RS16400	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AH4AK4_RS16440	COG0316	Belongs to the HesB IscA family
AH4AK4_RS16450	COG0038	chloride channel
AH4AK4_RS16455	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AH4AK4_RS16470	COG0671	phosphoesterase, PA-phosphatase related
AH4AK4_RS16480	COG0583	DNA-binding transcription factor activity
AH4AK4_RS16485	COG2076	Multidrug Resistance protein
AH4AK4_RS16495	COG0346	lactoylglutathione lyase activity
AH4AK4_RS16500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AH4AK4_RS16505	COG1643	Atp-dependent helicase
AH4AK4_RS16515	COG1489	DNA binding
AH4AK4_RS16520	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AH4AK4_RS16525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AH4AK4_RS16530	COG0617	tRNA 3'-terminal CCA addition
AH4AK4_RS16540	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AH4AK4_RS16545	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AH4AK4_RS16555	COG0842	Transport permease protein
AH4AK4_RS16560	COG1131	(ABC) transporter
AH4AK4_RS16575	COG0163	prenyltransferase activity
AH4AK4_RS16580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AH4AK4_RS16585	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AH4AK4_RS16600	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AH4AK4_RS16615	COG1136	(ABC) transporter
AH4AK4_RS16645	COG0529	Catalyzes the synthesis of activated sulfate
AH4AK4_RS16650	COG3273	potassium ion transport
AH4AK4_RS16650	COG0471	metal ion transport
AH4AK4_RS16655	COG2895	sulfate adenylyltransferase (ATP) activity
AH4AK4_RS16660	COG0175	sulfate reduction
AH4AK4_RS16665	COG1648	precorrin-2 dehydrogenase activity
AH4AK4_RS16665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AH4AK4_RS16670	COG0330	HflC and HflK could
AH4AK4_RS16675	COG1585	Membrane protein implicated in regulation of membrane protease activity
AH4AK4_RS16685	COG0673	inositol 2-dehydrogenase activity
AH4AK4_RS16695	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AH4AK4_RS16700	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AH4AK4_RS16705	COG3036	rescue of stalled ribosome
AH4AK4_RS16720	COG0138	bifunctional purine biosynthesis protein purh
AH4AK4_RS16725	COG0151	Belongs to the GarS family
AH4AK4_RS16755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AH4AK4_RS16765	COG1610	YqeY-like protein
AH4AK4_RS16775	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AH4AK4_RS16785	COG4942	peptidase
AH4AK4_RS16785	COG1388	LysM domain
AH4AK4_RS16790	COG1238	metal cluster binding
AH4AK4_RS16795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AH4AK4_RS16800	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AH4AK4_RS16805	COG0585	pseudouridine synthase activity
AH4AK4_RS16815	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AH4AK4_RS16820	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AH4AK4_RS16825	COG0148	phosphopyruvate hydratase activity
AH4AK4_RS16830	COG0504	CTP synthase activity
AH4AK4_RS16835	COG3956	TIGRFAM MazG family protein
AH4AK4_RS16840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AH4AK4_RS16845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AH4AK4_RS16855	COG4807	Protein conserved in bacteria
AH4AK4_RS16860	COG3023	N-Acetylmuramoyl-L-alanine amidase
AH4AK4_RS16865	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AH4AK4_RS16870	COG1381	Involved in DNA repair and RecF pathway recombination
AH4AK4_RS16880	COG0571	ribonuclease III activity
AH4AK4_RS16885	COG0681	Belongs to the peptidase S26 family
AH4AK4_RS16890	COG0481	GTPase activity
AH4AK4_RS16910	COG1595	DNA-templated transcription, initiation
AH4AK4_RS16915	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AH4AK4_RS16965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AH4AK4_RS16970	COG0191	fructose-bisphosphate aldolase activity
AH4AK4_RS16975	COG0126	phosphoglycerate kinase activity
AH4AK4_RS16980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AH4AK4_RS16985	COG1940	carbohydrate kinase activity
AH4AK4_RS16990	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AH4AK4_RS16995	COG2816	NAD+ diphosphatase activity
AH4AK4_RS17000	COG4991	sh3 domain protein
AH4AK4_RS17005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AH4AK4_RS17020	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AH4AK4_RS17025	COG1028	Short-chain dehydrogenase reductase Sdr
AH4AK4_RS17035	COG1505	serine-type exopeptidase activity
AH4AK4_RS17040	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AH4AK4_RS17045	COG0765	amino acid transport
AH4AK4_RS17050	COG0765	amino acid transport
AH4AK4_RS17055	COG1126	abc transporter atp-binding protein
AH4AK4_RS17060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH4AK4_RS17065	COG3174	membrane
AH4AK4_RS17070	COG0110	maltose O-acetyltransferase activity
AH4AK4_RS17090	COG4932	domain protein
AH4AK4_RS17090	COG5492	domain, Protein
AH4AK4_RS17115	COG1942	4-Oxalocrotonate Tautomerase
AH4AK4_RS17125	COG0583	DNA-binding transcription factor activity
AH4AK4_RS17130	COG0165	Argininosuccinate lyase
AH4AK4_RS17135	COG0137	argininosuccinate synthase activity
AH4AK4_RS17145	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AH4AK4_RS17150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AH4AK4_RS17160	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AH4AK4_RS17205	COG0583	DNA-binding transcription factor activity
AH4AK4_RS17210	COG1380	Effector of murein hydrolase LrgA
AH4AK4_RS17215	COG1346	cytolysis
AH4AK4_RS17220	COG0460	homoserine dehydrogenase
AH4AK4_RS17220	COG0527	aspartate kinase activity
AH4AK4_RS17225	COG0626	cystathionine gamma-synthase activity
AH4AK4_RS17240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AH4AK4_RS17245	COG0814	amino acid
AH4AK4_RS17250	COG1218	3'(2'),5'-bisphosphate nucleotidase
AH4AK4_RS17255	COG0494	nUDIX hydrolase
AH4AK4_RS17260	COG1011	Hydrolase
AH4AK4_RS17275	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AH4AK4_RS17290	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AH4AK4_RS17300	COG3156	type II secretion system protein K
AH4AK4_RS17305	COG4795	General secretion pathway protein
AH4AK4_RS17310	COG2165	general secretion pathway protein
AH4AK4_RS17320	COG2165	general secretion pathway protein
AH4AK4_RS17325	COG1459	type II secretion system
AH4AK4_RS17330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AH4AK4_RS17340	COG3031	protein transport across the cell outer membrane
AH4AK4_RS17350	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AH4AK4_RS17355	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AH4AK4_RS17375	COG3133	Outer membrane lipoprotein
AH4AK4_RS17380	COG3025	triphosphatase activity
AH4AK4_RS17385	COG1392	Phosphate transport regulator
AH4AK4_RS17390	COG0306	phosphate transporter
AH4AK4_RS17395	COG0617	tRNA 3'-terminal CCA addition
AH4AK4_RS17400	COG3409	Peptidoglycan-binding domain 1 protein
AH4AK4_RS17400	COG3267	Type II secretory pathway component ExeA
AH4AK4_RS17410	COG1194	a g-specific adenine glycosylase
AH4AK4_RS17415	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AH4AK4_RS17430	COG3240	lipase activity
AH4AK4_RS17440	COG3009	Protein conserved in bacteria
AH4AK4_RS17445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AH4AK4_RS17445	COG3008	intermembrane lipid transfer
AH4AK4_RS17450	COG2995	paraquat-inducible protein a
AH4AK4_RS17460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AH4AK4_RS17465	COG2203	Gaf domain
AH4AK4_RS17465	COG4251	negative regulation of phosphorylation
AH4AK4_RS17465	COG5001	Diguanylate cyclase
AH4AK4_RS17465	COG3706	GGDEF domain
AH4AK4_RS17470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AH4AK4_RS17475	COG2813	Specifically methylates the guanine in position
AH4AK4_RS17480	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AH4AK4_RS17485	COG0297	glycogen (starch) synthase activity
AH4AK4_RS17520	COG1757	Na H antiporter
AH4AK4_RS17525	COG0583	DNA-binding transcription factor activity
AH4AK4_RS17530	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AH4AK4_RS17535	COG3842	ATPase activity
AH4AK4_RS17540	COG1176	ABC-type spermidine putrescine transport system, permease component I
AH4AK4_RS17545	COG1177	transmembrane transport
AH4AK4_RS17550	COG1012	belongs to the aldehyde dehydrogenase family
AH4AK4_RS17555	COG0109	protoheme IX farnesyltransferase activity
AH4AK4_RS17585	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AH4AK4_RS17595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AH4AK4_RS17600	COG1444	tRNA N-acetyltransferase activity
AH4AK4_RS17620	COG1803	Methylglyoxal synthase
AH4AK4_RS17635	COG0252	asparaginase activity
AH4AK4_RS17645	COG1609	Transcriptional regulator
AH4AK4_RS17655	COG1940	carbohydrate kinase activity
AH4AK4_RS17660	COG1447	Phosphotransferase system cellobiose-specific component IIA
AH4AK4_RS17665	COG2723	6-phospho-beta-galactosidase activity
AH4AK4_RS17670	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AH4AK4_RS17670	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AH4AK4_RS17680	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AH4AK4_RS17690	COG1609	Transcriptional regulator
AH4AK4_RS17695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AH4AK4_RS17695	COG1263	PTS System
AH4AK4_RS17700	COG0366	Alpha amylase catalytic
AH4AK4_RS17705	COG0110	maltose O-acetyltransferase activity
AH4AK4_RS17710	COG1522	sequence-specific DNA binding
AH4AK4_RS17765	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AH4AK4_RS17770	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AH4AK4_RS17785	COG0477	Major facilitator Superfamily
AH4AK4_RS17790	COG0523	cobalamin synthesis protein
AH4AK4_RS17800	COG1280	lysine exporter protein (LysE YggA)
AH4AK4_RS17815	COG1028	Short-chain dehydrogenase reductase Sdr
AH4AK4_RS17820	COG2200	EAL domain
AH4AK4_RS17825	COG2200	EAL domain
AH4AK4_RS17830	COG1049	propionate catabolic process, 2-methylcitrate cycle
AH4AK4_RS17835	COG1752	Esterase of the alpha-beta hydrolase superfamily
AH4AK4_RS17840	COG0840	transmembrane signaling receptor activity
AH4AK4_RS17845	COG0840	transmembrane signaling receptor activity
AH4AK4_RS17855	COG3447	MASE1 domain protein
AH4AK4_RS17855	COG5002	protein histidine kinase activity
AH4AK4_RS17855	COG5001	Diguanylate cyclase
AH4AK4_RS17860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AH4AK4_RS17865	COG0508	dehydrogenase complex catalyzes the overall conversion of
AH4AK4_RS17870	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AH4AK4_RS17875	COG2186	Transcriptional regulator
AH4AK4_RS17895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AH4AK4_RS17900	COG1459	type II secretion system
AH4AK4_RS17915	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AH4AK4_RS17920	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AH4AK4_RS17925	COG0494	nUDIX hydrolase
AH4AK4_RS17930	COG0653	protein targeting
AH4AK4_RS17940	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AH4AK4_RS17945	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AH4AK4_RS17950	COG0849	cell division
AH4AK4_RS17955	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AH4AK4_RS17960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AH4AK4_RS17965	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AH4AK4_RS17970	COG0772	Belongs to the SEDS family
AH4AK4_RS17975	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AH4AK4_RS17980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AH4AK4_RS17985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AH4AK4_RS17990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AH4AK4_RS17995	COG0768	penicillin binding
AH4AK4_RS18000	COG3116	cell division
AH4AK4_RS18005	COG0275	rRNA processing
AH4AK4_RS18010	COG2001	Belongs to the MraZ family
AH4AK4_RS18020	COG0741	lytic transglycosylase activity
AH4AK4_RS18020	COG1388	LysM domain
AH4AK4_RS18030	COG1360	Flagellar Motor Protein
AH4AK4_RS18035	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AH4AK4_RS18040	COG1191	sigma factor activity
AH4AK4_RS18065	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AH4AK4_RS18070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AH4AK4_RS18075	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AH4AK4_RS18090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AH4AK4_RS18095	COG1256	bacterial-type flagellum assembly
AH4AK4_RS18095	COG4786	Flagellar basal body rod
AH4AK4_RS18105	COG1706	bacterial-type flagellum-dependent cell motility
AH4AK4_RS18110	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AH4AK4_RS18115	COG4786	Flagellar basal body rod
AH4AK4_RS18125	COG1749	Flagellar hook protein flgE
AH4AK4_RS18140	COG1815	bacterial-type flagellum-dependent cell motility
AH4AK4_RS18175	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AH4AK4_RS18185	COG1677	Flagellar hook-basal body complex protein FliE
AH4AK4_RS18210	COG1987	bacterial-type flagellum assembly
AH4AK4_RS18230	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AH4AK4_RS18235	COG3107	peptidoglycan biosynthetic process
AH4AK4_RS18240	COG0792	nuclease activity
AH4AK4_RS18245	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AH4AK4_RS18250	COG2823	Periplasmic or secreted lipoprotein
AH4AK4_RS18255	COG2969	positive regulation of protein catabolic process
AH4AK4_RS18260	COG0625	glutathione transferase activity
AH4AK4_RS18265	COG2857	Cytochrome c1
AH4AK4_RS18270	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AH4AK4_RS18275	COG0723	plastoquinol--plastocyanin reductase activity
AH4AK4_RS18280	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AH4AK4_RS18285	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AH4AK4_RS18290	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AH4AK4_RS18300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AH4AK4_RS18305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AH4AK4_RS18335	COG3964	amidohydrolase
AH4AK4_RS18350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AH4AK4_RS18350	COG3711	transcriptional antiterminator
AH4AK4_RS18355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AH4AK4_RS18360	COG1660	Displays ATPase and GTPase activities
AH4AK4_RS18365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AH4AK4_RS18380	COG1137	ATPase activity
AH4AK4_RS18385	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AH4AK4_RS18390	COG3117	lipopolysaccharide transmembrane transporter activity
AH4AK4_RS18395	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AH4AK4_RS18400	COG0517	IMP dehydrogenase activity
AH4AK4_RS18400	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AH4AK4_RS18405	COG1127	ABC transporter
AH4AK4_RS18410	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AH4AK4_RS18415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AH4AK4_RS18420	COG2854	intermembrane phospholipid transfer
AH4AK4_RS18430	COG5007	Belongs to the BolA IbaG family
AH4AK4_RS18435	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AH4AK4_RS18440	COG0312	modulator of DNA gyrase
AH4AK4_RS18445	COG3028	Belongs to the UPF0307 family
AH4AK4_RS18455	COG2926	Belongs to the UPF0265 family
AH4AK4_RS18490	COG1396	sequence-specific DNA binding
AH4AK4_RS18495	COG3135	benzoate transporter
AH4AK4_RS18525	COG3047	cAMP biosynthetic process
AH4AK4_RS18530	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AH4AK4_RS18535	COG2197	response regulator
AH4AK4_RS18540	COG0629	single-stranded DNA binding
AH4AK4_RS18555	COG1278	Cold shock
AH4AK4_RS18590	COG3706	GGDEF domain
AH4AK4_RS18595	COG0347	Belongs to the P(II) protein family
AH4AK4_RS18600	COG0004	ammonium transporteR
AH4AK4_RS18620	COG1309	transcriptional regulator
AH4AK4_RS18630	COG0346	lactoylglutathione lyase activity
AH4AK4_RS18635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AH4AK4_RS18640	COG1074	ATP-dependent DNA helicase activity
AH4AK4_RS18645	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AH4AK4_RS18650	COG2259	Doxx family
AH4AK4_RS18655	COG1741	Belongs to the pirin family
AH4AK4_RS18665	COG0583	DNA-binding transcription factor activity
AH4AK4_RS18690	COG1175	transmembrane transport
AH4AK4_RS18700	COG3842	ATPase activity
AH4AK4_RS18725	COG2207	Transcriptional regulator
AH4AK4_RS18730	COG1247	-acetyltransferase
AH4AK4_RS18735	COG0753	catalase activity
AH4AK4_RS18755	COG0671	phosphoesterase, PA-phosphatase related
AH4AK4_RS18760	COG0628	permease
AH4AK4_RS18770	COG3284	Transcriptional regulator
AH4AK4_RS18780	COG1461	Dihydroxyacetone kinase
AH4AK4_RS18785	COG2376	Dihydroxyacetone kinase
AH4AK4_RS18790	COG2252	PERMEase
AH4AK4_RS18795	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AH4AK4_RS18825	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AH4AK4_RS18830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AH4AK4_RS18835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AH4AK4_RS18840	COG0049	tRNA binding
AH4AK4_RS18850	COG2168	tRNA wobble position uridine thiolation
AH4AK4_RS18870	COG2964	Protein conserved in bacteria
AH4AK4_RS18875	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AH4AK4_RS18880	COG0085	RNA polymerase activity
AH4AK4_RS18885	COG0222	ribosome binding
AH4AK4_RS18890	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AH4AK4_RS18895	COG0081	regulation of translation
AH4AK4_RS18900	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AH4AK4_RS18905	COG0250	Participates in transcription elongation, termination and antitermination
AH4AK4_RS18920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AH4AK4_RS18945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AH4AK4_RS18950	COG0569	domain protein
AH4AK4_RS18955	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AH4AK4_RS18960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AH4AK4_RS18965	COG3005	denitrification pathway
AH4AK4_RS18970	COG0243	molybdopterin cofactor binding
AH4AK4_RS19000	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AH4AK4_RS19005	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AH4AK4_RS19015	COG2204	response regulator
AH4AK4_RS19025	COG2205	protein histidine kinase activity
AH4AK4_RS19040	COG0516	GMP reductase activity
AH4AK4_RS19040	COG0517	IMP dehydrogenase activity
AH4AK4_RS19045	COG5413	integral membrane protein
AH4AK4_RS19055	COG1522	sequence-specific DNA binding
AH4AK4_RS19060	COG2502	aspartate--ammonia ligase
AH4AK4_RS19065	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AH4AK4_RS19070	COG0542	response to heat
AH4AK4_RS19080	COG0564	pseudouridine synthase activity
AH4AK4_RS19085	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AH4AK4_RS19090	COG0446	pyridine nucleotide-disulphide oxidoreductase
AH4AK4_RS19100	COG3681	Belongs to the UPF0597 family
AH4AK4_RS19105	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AH4AK4_RS19110	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AH4AK4_RS19115	COG1979	alcohol dehydrogenase
AH4AK4_RS19120	COG2207	Transcriptional regulator
AH4AK4_RS19125	COG3040	lipid binding
AH4AK4_RS19135	COG0840	transmembrane signaling receptor activity
AH4AK4_RS19140	COG0688	phosphatidylethanolamine metabolic process
AH4AK4_RS19155	COG0540	Belongs to the ATCase OTCase family
AH4AK4_RS19160	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AH4AK4_RS19165	COG1438	arginine binding
AH4AK4_RS19170	COG1288	antiporter activity
AH4AK4_RS19175	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AH4AK4_RS19200	COG4211	Belongs to the binding-protein-dependent transport system permease family
AH4AK4_RS19215	COG3250	beta-galactosidase activity
AH4AK4_RS19220	COG1609	Transcriptional regulator
AH4AK4_RS19225	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AH4AK4_RS19235	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AH4AK4_RS19240	COG2017	converts alpha-aldose to the beta-anomer
AH4AK4_RS19250	COG2211	Major facilitator Superfamily
AH4AK4_RS19260	COG1609	Transcriptional regulator
AH4AK4_RS19275	COG1175	transmembrane transport
AH4AK4_RS19295	COG4580	involved in the transport of maltose and maltodextrins
AH4AK4_RS19300	COG0667	Aldo Keto reductase
AH4AK4_RS19305	COG1968	undecaprenyl-diphosphatase activity
AH4AK4_RS19310	COG3806	Anti-sigma factor
AH4AK4_RS19315	COG1595	DNA-templated transcription, initiation
AH4AK4_RS19325	COG0018	arginyl-trna synthetase
AH4AK4_RS19335	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AH4AK4_RS19340	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AH4AK4_RS19360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AH4AK4_RS19365	COG1131	(ABC) transporter
AH4AK4_RS19370	COG0842	Transport permease protein
AH4AK4_RS19375	COG0842	Transport permease protein
AH4AK4_RS19380	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AH4AK4_RS19390	COG2116	formate transmembrane transporter activity
AH4AK4_RS19395	COG1648	precorrin-2 dehydrogenase activity
AH4AK4_RS19395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AH4AK4_RS19400	COG2239	Acts as a magnesium transporter
AH4AK4_RS19405	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AH4AK4_RS19410	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AH4AK4_RS19420	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AH4AK4_RS19430	COG0514	ATP-dependent DNA helicase (RecQ)
AH4AK4_RS19435	COG2050	protein possibly involved in aromatic compounds catabolism
AH4AK4_RS19450	COG2258	MOSC domain
AH4AK4_RS19455	COG1177	transmembrane transport
AH4AK4_RS19460	COG1176	ABC-type spermidine putrescine transport system, permease component I
AH4AK4_RS19465	COG3842	ATPase activity
AH4AK4_RS19485	COG0174	glutamine synthetase
AH4AK4_RS19505	COG3045	CreA protein
AH4AK4_RS19510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AH4AK4_RS19515	COG0443	Heat shock 70 kDa protein
AH4AK4_RS19530	COG0366	Alpha amylase catalytic
AH4AK4_RS19545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AH4AK4_RS19550	COG0745	RESPONSE REGULATOR receiver
AH4AK4_RS19555	COG2205	protein histidine kinase activity
AH4AK4_RS19565	COG0281	malic enzyme
AH4AK4_RS19570	COG0702	epimerase
AH4AK4_RS19575	COG0254	rRNA binding
AH4AK4_RS19580	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AH4AK4_RS19595	COG0129	dihydroxy-acid dehydratase activity
AH4AK4_RS19605	COG3978	acetolactate synthase activity
AH4AK4_RS19615	COG0606	chelatase, subunit chli
AH4AK4_RS19620	COG0204	Acyl-transferase
AH4AK4_RS19625	COG0204	Acyl-transferase
AH4AK4_RS19630	COG1683	Conserved Protein
AH4AK4_RS19640	COG1335	isochorismatase
AH4AK4_RS19650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AH4AK4_RS19655	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AH4AK4_RS19665	COG3084	Protein conserved in bacteria
AH4AK4_RS19670	COG5001	Diguanylate cyclase
AH4AK4_RS19670	COG4251	negative regulation of phosphorylation
AH4AK4_RS19670	COG3706	GGDEF domain
AH4AK4_RS19670	COG2203	Gaf domain
AH4AK4_RS19675	COG0789	Transcriptional regulator
AH4AK4_RS19685	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AH4AK4_RS19690	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AH4AK4_RS19695	COG1561	YicC-like family, N-terminal region
AH4AK4_RS19705	COG1519	Transferase
AH4AK4_RS19710	COG0859	PFAM glycosyl transferase family 9
AH4AK4_RS19715	COG0463	Glycosyl transferase, family 2
AH4AK4_RS19720	COG0859	PFAM glycosyl transferase family 9
AH4AK4_RS19725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AH4AK4_RS19730	COG2990	Protein conserved in bacteria
AH4AK4_RS19735	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AH4AK4_RS19745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AH4AK4_RS19750	COG2003	Belongs to the UPF0758 family
AH4AK4_RS19755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AH4AK4_RS19760	COG0756	dUTP diphosphatase activity
AH4AK4_RS19765	COG1309	transcriptional regulator
AH4AK4_RS19770	COG0668	transmembrane transport
AH4AK4_RS19775	COG0166	Belongs to the GPI family
AH4AK4_RS19780	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AH4AK4_RS19785	COG0583	DNA-binding transcription factor activity
AH4AK4_RS19795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AH4AK4_RS19795	COG0045	succinate-CoA ligase (ADP-forming) activity
AH4AK4_RS19795	COG1042	CoA-binding domain protein
AH4AK4_RS19825	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
AH4AK4_RS19830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AH4AK4_RS19835	COG1739	Uncharacterized protein family UPF0029
AH4AK4_RS19840	COG0006	proline dipeptidase activity
AH4AK4_RS19845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AH4AK4_RS19850	COG1024	Enoyl-CoA hydratase
AH4AK4_RS19850	COG1250	3-hydroxyacyl-CoA dehydrogenase
AH4AK4_RS19855	COG0183	Belongs to the thiolase family
AH4AK4_RS19880	COG0425	Belongs to the sulfur carrier protein TusA family
AH4AK4_RS19885	COG0251	oxidation-reduction process
AH4AK4_RS19890	COG2885	chlorophyll binding
AH4AK4_RS19915	COG2818	Glycosylase
AH4AK4_RS19920	COG0752	glycyl-tRNA synthetase alpha subunit
AH4AK4_RS19925	COG0751	glycine-tRNA ligase activity
AH4AK4_RS19940	COG0640	Transcriptional regulator
AH4AK4_RS19950	COG0814	amino acid
AH4AK4_RS19955	COG0814	amino acid
AH4AK4_RS19960	COG3033	Beta-eliminating lyase
AH4AK4_RS19975	COG0446	pyridine nucleotide-disulphide oxidoreductase
AH4AK4_RS19980	COG0426	domain, Protein
AH4AK4_RS19980	COG1773	rubredoxin
AH4AK4_RS19985	COG3604	Transcriptional regulator
AH4AK4_RS19990	COG1609	Transcriptional regulator
AH4AK4_RS20030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AH4AK4_RS20045	COG2960	long-chain fatty acid transporting porin activity
AH4AK4_RS20055	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AH4AK4_RS20070	COG3118	belongs to the thioredoxin family
AH4AK4_RS20075	COG0513	Belongs to the DEAD box helicase family
AH4AK4_RS20080	COG0248	Ppx GppA phosphatase
AH4AK4_RS20095	COG0742	ribosomal rna small subunit methyltransferase
AH4AK4_RS20115	COG0084	hydrolase, TatD family'
AH4AK4_RS20120	COG0805	protein transport
AH4AK4_RS20125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AH4AK4_RS20130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AH4AK4_RS20135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AH4AK4_RS20140	COG3165	ubiquinone biosynthetic process from chorismate
AH4AK4_RS20150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AH4AK4_RS20155	COG0402	S-adenosylhomocysteine deaminase activity
AH4AK4_RS20195	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AH4AK4_RS20200	COG0848	biopolymer transport protein
AH4AK4_RS20205	COG0811	peptide transport
AH4AK4_RS20210	COG0811	peptide transport
AH4AK4_RS20220	COG2771	luxR family
AH4AK4_RS20230	COG1349	DNA-binding transcription factor activity
AH4AK4_RS20235	COG0745	RESPONSE REGULATOR receiver
AH4AK4_RS20240	COG2205	protein histidine kinase activity
AH4AK4_RS20250	COG4452	Inner membrane protein CreD
AH4AK4_RS20255	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AH4AK4_RS20260	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AH4AK4_RS20265	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AH4AK4_RS20270	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AH4AK4_RS20275	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AH4AK4_RS20280	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AH4AK4_RS20285	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AH4AK4_RS20295	COG0356	it plays a direct role in the translocation of protons across the membrane
AH4AK4_RS20305	COG1475	DNA binding
AH4AK4_RS20310	COG1192	Involved in chromosome partitioning
AH4AK4_RS20315	COG0357	Ribosomal RNA small subunit methyltransferase G
AH4AK4_RS20320	COG0445	tRNA wobble uridine modification
AH4AK4_RS20325	COG0716	FMN binding
AH4AK4_RS20330	COG4774	siderophore transport
AH4AK4_RS20335	COG4615	Cyclic peptide transporter
AH4AK4_RS20340	COG1120	ATPase activity
AH4AK4_RS20345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AH4AK4_RS20355	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AH4AK4_RS20360	COG0706	membrane insertase activity
AH4AK4_RS20365	COG0594	ribonuclease P activity
AH4AK4_RS20370	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AH4AK4_RS20375	COG1126	abc transporter atp-binding protein
AH4AK4_RS20410	COG5492	domain, Protein
AH4AK4_RS20410	COG4932	domain protein
AH4AK4_RS20420	COG3064	Membrane
AH4AK4_RS20440	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)