locus-tag	class	description
RY45_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RY45_RS00010	COG0592	DNA-directed DNA polymerase activity
RY45_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RY45_RS00030	COG2378	regulation of single-species biofilm formation
RY45_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
RY45_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
RY45_RS00045	COG3977	Valine--pyruvate aminotransferase
RY45_RS00060	COG2814	Major facilitator Superfamily
RY45_RS00065	COG0745	RESPONSE REGULATOR receiver
RY45_RS00070	COG2205	protein histidine kinase activity
RY45_RS00090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RY45_RS00095	COG4191	Histidine kinase
RY45_RS00095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RY45_RS00100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RY45_RS00105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RY45_RS00110	COG1309	transcriptional regulator
RY45_RS00140	COG0469	pyruvate kinase activity
RY45_RS00145	COG2271	Major facilitator Superfamily
RY45_RS00170	COG0561	phosphatase activity
RY45_RS00175	COG2267	carboxylic ester hydrolase activity
RY45_RS00185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RY45_RS00190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RY45_RS00195	COG1758	RNA polymerase activity
RY45_RS00205	COG0859	PFAM glycosyl transferase family 9
RY45_RS00210	COG3642	lipopolysaccharide core region biosynthetic process
RY45_RS00245	COG0589	response to stress
RY45_RS00250	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RY45_RS00255	COG3706	GGDEF domain
RY45_RS00260	COG1528	Iron-storage protein
RY45_RS00265	COG2081	HI0933 family
RY45_RS00270	COG2223	nitrite transmembrane transporter activity
RY45_RS00290	COG3188	usher protein
RY45_RS00310	COG2205	protein histidine kinase activity
RY45_RS00310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RY45_RS00320	COG3275	phosphorelay sensor kinase activity
RY45_RS00325	COG3279	Response regulator of the LytR AlgR family
RY45_RS00330	COG2223	nitrite transmembrane transporter activity
RY45_RS00335	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RY45_RS00340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RY45_RS00490	COG4695	Portal protein
RY45_RS00620	COG4974	Belongs to the 'phage' integrase family
RY45_RS00625	COG0583	DNA-binding transcription factor activity
RY45_RS00630	COG4206	TonB-dependent receptor
RY45_RS00680	COG0402	S-adenosylhomocysteine deaminase activity
RY45_RS00685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RY45_RS00695	COG3165	ubiquinone biosynthetic process from chorismate
RY45_RS00700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RY45_RS00710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RY45_RS00715	COG0805	protein transport
RY45_RS00720	COG0084	hydrolase, TatD family'
RY45_RS00740	COG0742	ribosomal rna small subunit methyltransferase
RY45_RS00755	COG0248	Ppx GppA phosphatase
RY45_RS00760	COG0513	Belongs to the DEAD box helicase family
RY45_RS00765	COG3118	belongs to the thioredoxin family
RY45_RS00780	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RY45_RS00805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RY45_RS00845	COG1609	Transcriptional regulator
RY45_RS00860	COG2188	Transcriptional regulator
RY45_RS00865	COG3604	Transcriptional regulator
RY45_RS00870	COG1773	rubredoxin
RY45_RS00870	COG0426	domain, Protein
RY45_RS00875	COG0446	pyridine nucleotide-disulphide oxidoreductase
RY45_RS00885	COG0348	domain, Protein
RY45_RS00890	COG0814	amino acid
RY45_RS00925	COG0751	glycine-tRNA ligase activity
RY45_RS00930	COG0752	glycyl-tRNA synthetase alpha subunit
RY45_RS00935	COG2818	Glycosylase
RY45_RS00940	COG1335	isochorismatase
RY45_RS00945	COG2885	chlorophyll binding
RY45_RS00955	COG0251	oxidation-reduction process
RY45_RS00960	COG0425	Belongs to the sulfur carrier protein TusA family
RY45_RS00985	COG0183	Belongs to the thiolase family
RY45_RS00990	COG1024	Enoyl-CoA hydratase
RY45_RS00990	COG1250	3-hydroxyacyl-CoA dehydrogenase
RY45_RS00995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RY45_RS01000	COG0006	proline dipeptidase activity
RY45_RS01005	COG1739	Uncharacterized protein family UPF0029
RY45_RS01010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RY45_RS01015	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
RY45_RS01055	COG0583	DNA-binding transcription factor activity
RY45_RS01060	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RY45_RS01065	COG0166	Belongs to the GPI family
RY45_RS01080	COG0668	transmembrane transport
RY45_RS01085	COG1309	transcriptional regulator
RY45_RS01090	COG0756	dUTP diphosphatase activity
RY45_RS01095	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RY45_RS01100	COG2003	Belongs to the UPF0758 family
RY45_RS01105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RY45_RS01115	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RY45_RS01120	COG2990	Protein conserved in bacteria
RY45_RS01125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RY45_RS01130	COG0859	PFAM glycosyl transferase family 9
RY45_RS01135	COG0463	Glycosyl transferase, family 2
RY45_RS01140	COG0859	PFAM glycosyl transferase family 9
RY45_RS01145	COG1519	Transferase
RY45_RS01165	COG1609	Transcriptional regulator
RY45_RS01170	COG0604	alcohol dehydrogenase
RY45_RS01180	COG1580	Controls the rotational direction of flagella during chemotaxis
RY45_RS01185	COG3161	chorismate lyase activity
RY45_RS01190	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RY45_RS01195	COG2937	Belongs to the GPAT DAPAT family
RY45_RS01200	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RY45_RS01215	COG0534	Mate efflux family protein
RY45_RS01220	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RY45_RS01225	COG2205	protein histidine kinase activity
RY45_RS01230	COG0745	RESPONSE REGULATOR receiver
RY45_RS01240	COG1045	serine acetyltransferase
RY45_RS01250	COG3074	FtsZ-dependent cytokinesis
RY45_RS01255	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
RY45_RS01260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RY45_RS01260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RY45_RS01265	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RY45_RS01305	COG1609	Transcriptional regulator
RY45_RS01310	COG3250	beta-galactosidase activity
RY45_RS01315	COG2731	YhcH YjgK YiaL family protein
RY45_RS01320	COG0531	amino acid
RY45_RS01325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RY45_RS01330	COG0531	amino acid
RY45_RS01335	COG0385	Bile acid
RY45_RS01340	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RY45_RS01360	COG0583	DNA-binding transcription factor activity
RY45_RS01365	COG1079	Belongs to the binding-protein-dependent transport system permease family
RY45_RS01370	COG4603	Belongs to the binding-protein-dependent transport system permease family
RY45_RS01375	COG3845	ABC transporter
RY45_RS01380	COG1744	ABC transporter substrate-binding protein PnrA-like
RY45_RS01385	COG0210	DNA helicase
RY45_RS01405	COG0583	DNA-binding transcription factor activity
RY45_RS01460	COG1280	lysine exporter protein (LysE YggA)
RY45_RS01470	COG2391	methyltransferase activity
RY45_RS01480	COG1280	lysine exporter protein (LysE YggA)
RY45_RS01490	COG2962	Rard protein
RY45_RS01500	COG1012	belongs to the aldehyde dehydrogenase family
RY45_RS01505	COG1396	sequence-specific DNA binding
RY45_RS01510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RY45_RS01520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RY45_RS01520	COG0519	Catalyzes the synthesis of GMP from XMP
RY45_RS01525	COG0686	Belongs to the AlaDH PNT family
RY45_RS01530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RY45_RS01550	COG1322	Protein conserved in bacteria
RY45_RS01555	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RY45_RS01560	COG0569	domain protein
RY45_RS01565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RY45_RS01565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RY45_RS01570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RY45_RS01575	COG0242	peptide deformylase activity
RY45_RS01585	COG0758	DNA mediated transformation
RY45_RS01590	COG2922	Belongs to the Smg family
RY45_RS01595	COG0551	DNA topoisomerase type I activity
RY45_RS01605	COG0009	L-threonylcarbamoyladenylate synthase
RY45_RS01610	COG0408	coproporphyrinogen oxidase activity
RY45_RS01615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RY45_RS01625	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RY45_RS01640	COG3078	GTPase activator activity
RY45_RS01650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RY45_RS01655	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RY45_RS01660	COG2204	response regulator
RY45_RS01665	COG3852	Histidine kinase
RY45_RS01675	COG0174	glutamine synthetase
RY45_RS01680	COG1217	gtp-binding protein TYPA
RY45_RS01685	COG1295	ribonuclease BN
RY45_RS01690	COG1295	ribonuclease BN
RY45_RS01695	COG1490	D-aminoacyl-tRNA deacylase activity
RY45_RS01710	COG0456	acetyltransferase
RY45_RS01720	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RY45_RS01725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RY45_RS01730	COG2610	gluconate transmembrane transporter activity
RY45_RS01735	COG3265	gluconokinase activity
RY45_RS01740	COG0129	dihydroxy-acid dehydratase activity
RY45_RS01745	COG0800	Aldolase
RY45_RS01750	COG1609	Transcriptional regulator
RY45_RS01760	COG4942	peptidase
RY45_RS01765	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
RY45_RS01770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RY45_RS01775	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RY45_RS01780	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RY45_RS01785	COG0316	Belongs to the HesB IscA family
RY45_RS01785	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
RY45_RS01790	COG1040	competence protein
RY45_RS01795	COG0596	Alpha beta hydrolase
RY45_RS01815	COG2183	response to ionizing radiation
RY45_RS01820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RY45_RS01840	COG0051	transcription antitermination factor activity, RNA binding
RY45_RS01845	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RY45_RS01850	COG0088	Forms part of the polypeptide exit tunnel
RY45_RS01855	COG0089	rRNA binding
RY45_RS01860	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RY45_RS01865	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RY45_RS01870	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RY45_RS01875	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RY45_RS01880	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RY45_RS01885	COG0255	Belongs to the universal ribosomal protein uL29 family
RY45_RS01890	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RY45_RS01895	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RY45_RS01900	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RY45_RS01905	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RY45_RS01910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RY45_RS01915	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RY45_RS01920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RY45_RS01925	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RY45_RS01930	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RY45_RS01935	COG0200	Binds to the 23S rRNA
RY45_RS01940	COG0201	protein transport
RY45_RS01945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RY45_RS01950	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RY45_RS01955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RY45_RS01960	COG0202	RNA polymerase activity
RY45_RS01965	COG0203	ribosomal protein L17
RY45_RS02015	COG2249	NAD(P)H dehydrogenase (quinone) activity
RY45_RS02020	COG0583	DNA-binding transcription factor activity
RY45_RS02025	COG4221	oxidoreductase activity
RY45_RS02040	COG1770	oligopeptidase
RY45_RS02055	COG3714	YhhN family
RY45_RS02080	COG1301	dicarboxylic acid transport
RY45_RS02090	COG2095	MarC family integral membrane protein
RY45_RS02100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RY45_RS02110	COG0741	lytic transglycosylase activity
RY45_RS02115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RY45_RS02140	COG0742	ribosomal rna small subunit methyltransferase
RY45_RS02145	COG0552	protein localization to endoplasmic reticulum
RY45_RS02150	COG2884	Cell division ATP-binding protein ftsE
RY45_RS02155	COG2177	Part of the ABC transporter FtsEX involved in
RY45_RS02165	COG0288	reversible hydration of carbon dioxide
RY45_RS02170	COG2188	Transcriptional regulator
RY45_RS02175	COG1228	amidohydrolase
RY45_RS02180	COG0010	Belongs to the arginase family
RY45_RS02185	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RY45_RS02190	COG2986	histidine ammonia-lyase
RY45_RS02195	COG0387	Pfam Sodium calcium exchanger
RY45_RS02200	COG2200	EAL domain
RY45_RS02205	COG2200	EAL domain
RY45_RS02205	COG2199	diguanylate cyclase activity
RY45_RS02250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RY45_RS02255	COG1459	type II secretion system
RY45_RS02265	COG2165	general secretion pathway protein
RY45_RS02270	COG2165	general secretion pathway protein
RY45_RS02275	COG4968	Prepilin-type N-terminal cleavage methylation domain
RY45_RS02300	COG1077	Cell shape determining protein MreB Mrl
RY45_RS02305	COG1792	Involved in formation and maintenance of cell shape
RY45_RS02310	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
RY45_RS02315	COG0424	maF-like protein
RY45_RS02320	COG1530	ribonuclease E activity
RY45_RS02325	COG3164	Protein of unknown function
RY45_RS02335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RY45_RS02340	COG0312	modulator of DNA gyrase
RY45_RS02360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RY45_RS02360	COG1263	PTS System
RY45_RS02365	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
RY45_RS02385	COG0477	Major facilitator Superfamily
RY45_RS02395	COG3437	response regulator, receiver
RY45_RS02400	COG0784	Response regulator, receiver
RY45_RS02400	COG2205	protein histidine kinase activity
RY45_RS02400	COG5002	protein histidine kinase activity
RY45_RS02405	COG2172	sigma factor antagonist activity
RY45_RS02410	COG1366	Belongs to the anti-sigma-factor antagonist family
RY45_RS02430	COG3700	Belongs to the class B bacterial acid phosphatase family
RY45_RS02435	COG2321	neutral zinc metallopeptidase
RY45_RS02445	COG1639	'signal transduction protein
RY45_RS02470	COG0189	ligase activity
RY45_RS02480	COG0642	Histidine kinase
RY45_RS02485	COG0745	RESPONSE REGULATOR receiver
RY45_RS02505	COG3766	membrane
RY45_RS02510	COG0754	glutathionylspermidine amidase activity
RY45_RS02515	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RY45_RS02520	COG0352	thiamine-phosphate diphosphorylase activity
RY45_RS02525	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RY45_RS02535	COG2022	thiamine diphosphate biosynthetic process
RY45_RS02540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RY45_RS02555	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
RY45_RS02580	COG0814	amino acid
RY45_RS02585	COG3932	Exopolysaccharide synthesis, ExoD
RY45_RS02605	COG1733	regulation of RNA biosynthetic process
RY45_RS02645	COG1494	fructose-1,6-bisphosphatase
RY45_RS02660	COG2959	enzyme of heme biosynthesis
RY45_RS02670	COG0181	hydroxymethylbilane synthase activity
RY45_RS02675	COG3072	Adenylate cyclase
RY45_RS02680	COG0400	carboxylic ester hydrolase activity
RY45_RS02685	COG1965	Belongs to the frataxin family
RY45_RS02690	COG0019	diaminopimelate decarboxylase activity
RY45_RS02695	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RY45_RS02710	COG1011	Hydrolase
RY45_RS02730	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RY45_RS02735	COG0561	phosphatase activity
RY45_RS02750	COG1129	ABC transporter
RY45_RS02750	COG0842	Transport permease protein
RY45_RS02765	COG1546	Belongs to the CinA family
RY45_RS02765	COG1058	Belongs to the CinA family
RY45_RS02770	COG1418	mRNA catabolic process
RY45_RS02775	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
RY45_RS02785	COG1522	sequence-specific DNA binding
RY45_RS02790	COG1368	sulfuric ester hydrolase activity
RY45_RS02810	COG1285	pathogenesis
RY45_RS02830	COG4221	oxidoreductase activity
RY45_RS02900	COG3093	addiction module antidote protein HigA
RY45_RS02970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RY45_RS02970	COG0426	domain, Protein
RY45_RS02980	COG1979	alcohol dehydrogenase
RY45_RS02990	COG2873	o-acetylhomoserine
RY45_RS02995	COG4533	DNA binding
RY45_RS03010	COG5380	lipid catabolic process
RY45_RS03015	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
RY45_RS03025	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RY45_RS03030	COG2949	membrane
RY45_RS03035	COG3291	Pkd domain containing protein
RY45_RS03055	COG3188	usher protein
RY45_RS03060	COG3121	Chaperone
RY45_RS03080	COG0318	PFAM AMP-dependent synthetase and ligase
RY45_RS03085	COG1441	menaquinone biosynthetic process
RY45_RS03090	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RY45_RS03095	COG0596	Alpha beta hydrolase
RY45_RS03100	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
RY45_RS03105	COG1169	isochorismate synthase
RY45_RS03110	COG1575	Belongs to the MenA family. Type 1 subfamily
RY45_RS03135	COG0513	Belongs to the DEAD box helicase family
RY45_RS03140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RY45_RS03145	COG1988	membrane-bound metal-dependent
RY45_RS03160	COG1671	Belongs to the UPF0178 family
RY45_RS03185	COG3263	regulation of cellular component size
RY45_RS03190	COG3722	fumarate hydratase activity
RY45_RS03195	COG0246	Mannitol dehydrogenase
RY45_RS03200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RY45_RS03200	COG2213	PTS system mannitol-specific
RY45_RS03210	COG1309	transcriptional regulator
RY45_RS03215	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
RY45_RS03225	COG3916	Acyl-homoserine-lactone synthase
RY45_RS03230	COG2771	luxR family
RY45_RS03245	COG3133	Outer membrane lipoprotein
RY45_RS03250	COG0456	acetyltransferase
RY45_RS03270	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
RY45_RS03275	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RY45_RS03285	COG3031	protein transport across the cell outer membrane
RY45_RS03295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RY45_RS03300	COG1459	type II secretion system
RY45_RS03305	COG2165	general secretion pathway protein
RY45_RS03315	COG2165	general secretion pathway protein
RY45_RS03320	COG4795	General secretion pathway protein
RY45_RS03325	COG3156	type II secretion system protein K
RY45_RS03335	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
RY45_RS03350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RY45_RS03355	COG1011	Hydrolase
RY45_RS03360	COG0494	nUDIX hydrolase
RY45_RS03365	COG1218	3'(2'),5'-bisphosphate nucleotidase
RY45_RS03370	COG0814	amino acid
RY45_RS03375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RY45_RS03380	COG3708	Transcriptional regulator
RY45_RS03380	COG2207	Transcriptional regulator
RY45_RS03390	COG0626	cystathionine gamma-synthase activity
RY45_RS03395	COG0527	aspartate kinase activity
RY45_RS03395	COG0460	homoserine dehydrogenase
RY45_RS03400	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RY45_RS03410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RY45_RS03415	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RY45_RS03425	COG0137	argininosuccinate synthase activity
RY45_RS03430	COG0165	Argininosuccinate lyase
RY45_RS03455	COG0110	maltose O-acetyltransferase activity
RY45_RS03460	COG3174	membrane
RY45_RS03465	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RY45_RS03475	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
RY45_RS03480	COG4208	sulfate ABC transporter
RY45_RS03485	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RY45_RS03490	COG0583	DNA-binding transcription factor activity
RY45_RS03495	COG3397	chitin binding
RY45_RS03500	COG0840	transmembrane signaling receptor activity
RY45_RS03530	COG4946	Tricorn protease homolog
RY45_RS03530	COG0793	Belongs to the peptidase S41A family
RY45_RS03550	COG1328	CTP reductase activity
RY45_RS03555	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RY45_RS03570	COG1448	Aminotransferase
RY45_RS03610	COG0513	Belongs to the DEAD box helicase family
RY45_RS03630	COG0840	transmembrane signaling receptor activity
RY45_RS03645	COG3112	Uncharacterised protein family (UPF0231)
RY45_RS03650	COG3835	regulator
RY45_RS03655	COG2610	gluconate transmembrane transporter activity
RY45_RS03660	COG1929	Belongs to the glycerate kinase type-1 family
RY45_RS03675	COG0583	DNA-binding transcription factor activity
RY45_RS03680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RY45_RS03695	COG0347	Belongs to the P(II) protein family
RY45_RS03700	COG1840	ABC-type Fe3 transport system, periplasmic component
RY45_RS03710	COG3842	ATPase activity
RY45_RS03715	COG2837	iron assimilation
RY45_RS03720	COG1438	arginine binding
RY45_RS03725	COG1126	abc transporter atp-binding protein
RY45_RS03730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RY45_RS03735	COG4215	(ABC) transporter
RY45_RS03740	COG4160	amino acid transport
RY45_RS03745	COG0039	L-malate dehydrogenase activity
RY45_RS03755	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RY45_RS03760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RY45_RS03760	COG1017	nitric oxide dioxygenase activity
RY45_RS03770	COG4536	flavin adenine dinucleotide binding
RY45_RS03775	COG4137	Cytochrome C assembly protein
RY45_RS03780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RY45_RS03785	COG0228	four-way junction DNA binding
RY45_RS03790	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RY45_RS03795	COG0336	Belongs to the RNA methyltransferase TrmD family
RY45_RS03800	COG0335	large ribosomal subunit rRNA binding
RY45_RS03810	COG3066	DNA modification
RY45_RS03820	COG1051	belongs to the nudix hydrolase family
RY45_RS03830	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RY45_RS03835	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RY45_RS03840	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RY45_RS03850	COG0583	DNA-binding transcription factor activity
RY45_RS03855	COG0640	Transcriptional regulator
RY45_RS03860	COG0268	Binds directly to 16S ribosomal RNA
RY45_RS03865	COG0728	peptidoglycan biosynthetic process
RY45_RS03870	COG0196	riboflavin kinase activity
RY45_RS03875	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RY45_RS03880	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RY45_RS03885	COG1047	Peptidyl-prolyl cis-trans
RY45_RS03890	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RY45_RS03950	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RY45_RS03950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RY45_RS03965	COG1854	S-ribosylhomocysteine lyase activity
RY45_RS03970	COG3706	GGDEF domain
RY45_RS03975	COG0557	exoribonuclease II activity
RY45_RS03985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RY45_RS03995	COG2153	protein acetylation
RY45_RS04015	COG1914	H( )-stimulated, divalent metal cation uptake system
RY45_RS04020	COG0360	Binds together with S18 to 16S ribosomal RNA
RY45_RS04025	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RY45_RS04030	COG0359	binds to the 23S rRNA
RY45_RS04035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RY45_RS04055	COG1238	metal cluster binding
RY45_RS04060	COG0612	Peptidase, M16
RY45_RS04065	COG2918	glutathione biosynthetic process
RY45_RS04075	COG1022	Amp-dependent synthetase and ligase
RY45_RS04085	COG0456	acetyltransferase
RY45_RS04095	COG0714	Associated with various cellular activities
RY45_RS04135	COG1902	pentaerythritol trinitrate reductase activity
RY45_RS04140	COG1309	transcriptional regulator
RY45_RS04145	COG2852	Protein conserved in bacteria
RY45_RS04155	COG2957	Belongs to the agmatine deiminase family
RY45_RS04160	COG0154	amidase activity
RY45_RS04190	COG0513	Belongs to the DEAD box helicase family
RY45_RS04225	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
RY45_RS04255	COG2070	2-Nitropropane dioxygenase
RY45_RS04290	COG2816	NAD+ diphosphatase activity
RY45_RS04295	COG2205	protein histidine kinase activity
RY45_RS04300	COG0745	RESPONSE REGULATOR receiver
RY45_RS04305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RY45_RS04310	COG1136	(ABC) transporter
RY45_RS04310	COG0577	efflux transmembrane transporter activity
RY45_RS04315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RY45_RS04320	COG1126	abc transporter atp-binding protein
RY45_RS04325	COG0765	amino acid transport
RY45_RS04330	COG0765	amino acid transport
RY45_RS04335	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RY45_RS04340	COG1505	serine-type exopeptidase activity
RY45_RS04360	COG1028	Short-chain dehydrogenase reductase Sdr
RY45_RS04365	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RY45_RS04380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RY45_RS04385	COG4991	sh3 domain protein
RY45_RS04395	COG2816	NAD+ diphosphatase activity
RY45_RS04405	COG1940	carbohydrate kinase activity
RY45_RS04410	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RY45_RS04415	COG0126	phosphoglycerate kinase activity
RY45_RS04425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RY45_RS04435	COG4232	protein-disulfide reductase activity
RY45_RS04465	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RY45_RS04475	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RY45_RS04480	COG1595	DNA-templated transcription, initiation
RY45_RS04485	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
RY45_RS04500	COG0481	GTPase activity
RY45_RS04505	COG0681	Belongs to the peptidase S26 family
RY45_RS04510	COG0571	ribonuclease III activity
RY45_RS04520	COG1381	Involved in DNA repair and RecF pathway recombination
RY45_RS04525	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RY45_RS04540	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RY45_RS04545	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RY45_RS04550	COG3716	PTS system mannose fructose sorbose family IID component
RY45_RS04560	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RY45_RS04565	COG2222	sugar isomerase
RY45_RS04575	COG1349	DNA-binding transcription factor activity
RY45_RS04580	COG3023	N-Acetylmuramoyl-L-alanine amidase
RY45_RS04585	COG4807	Protein conserved in bacteria
RY45_RS04595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RY45_RS04600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RY45_RS04605	COG3956	TIGRFAM MazG family protein
RY45_RS04610	COG0504	CTP synthase activity
RY45_RS04615	COG0148	phosphopyruvate hydratase activity
RY45_RS04620	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
RY45_RS04625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RY45_RS04635	COG0585	pseudouridine synthase activity
RY45_RS04640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RY45_RS04645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RY45_RS04650	COG1238	metal cluster binding
RY45_RS04665	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RY45_RS04670	COG1610	YqeY-like protein
RY45_RS04675	COG0358	DNA primase activity
RY45_RS04680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RY45_RS04710	COG0151	Belongs to the GarS family
RY45_RS04715	COG0138	bifunctional purine biosynthesis protein purh
RY45_RS04725	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
RY45_RS04730	COG3036	rescue of stalled ribosome
RY45_RS04735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RY45_RS04740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RY45_RS04750	COG0673	inositol 2-dehydrogenase activity
RY45_RS04760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RY45_RS04765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RY45_RS04770	COG3227	Zinc metalloprotease (Elastase)
RY45_RS04780	COG0477	Major facilitator Superfamily
RY45_RS04790	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RY45_RS04795	COG1027	Aspartate ammonia-lyase
RY45_RS04800	COG3030	protein affecting phage T7 exclusion by the F plasmid
RY45_RS04805	COG0534	Mate efflux family protein
RY45_RS04810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RY45_RS04815	COG0459	protein refolding
RY45_RS04825	COG5001	Diguanylate cyclase
RY45_RS04825	COG3300	MHYT domain
RY45_RS04830	COG0564	pseudouridine synthase activity
RY45_RS04835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RY45_RS04880	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RY45_RS04885	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
RY45_RS04890	COG1178	ABC-type Fe3 transport system permease component
RY45_RS04895	COG4143	(ABC) transporter
RY45_RS04910	COG0066	3-isopropylmalate dehydratase activity
RY45_RS04915	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RY45_RS04920	COG0473	3-isopropylmalate dehydrogenase activity
RY45_RS04925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RY45_RS04935	COG0671	phosphoesterase, PA-phosphatase related
RY45_RS04940	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RY45_RS04945	COG0028	Belongs to the TPP enzyme family
RY45_RS04955	COG0280	phosphate acetyltransferase
RY45_RS04955	COG0857	belongs to the CobB CobQ family
RY45_RS04960	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RY45_RS04970	COG3013	Belongs to the UPF0304 family
RY45_RS04975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RY45_RS04980	COG2716	regulation of RNA biosynthetic process
RY45_RS04990	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RY45_RS04995	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RY45_RS05010	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
RY45_RS05030	COG0784	Response regulator, receiver
RY45_RS05030	COG5002	protein histidine kinase activity
RY45_RS05030	COG2198	Histidine kinase
RY45_RS05055	COG0840	transmembrane signaling receptor activity
RY45_RS05065	COG1464	Belongs to the NlpA lipoprotein family
RY45_RS05070	COG2011	ABC-type metal ion transport system permease component
RY45_RS05075	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RY45_RS05095	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RY45_RS05100	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RY45_RS05100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RY45_RS05105	COG0802	atpase or kinase
RY45_RS05115	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RY45_RS05120	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RY45_RS05125	COG1923	regulation of RNA biosynthetic process
RY45_RS05130	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RY45_RS05135	COG0330	HflC and HflK could
RY45_RS05140	COG0330	HflC and HflK could
RY45_RS05145	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
RY45_RS05150	COG0142	geranyltranstransferase activity
RY45_RS05160	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RY45_RS05165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RY45_RS05170	COG3314	Sporulation integral membrane protein YlbJ
RY45_RS05175	COG0318	PFAM AMP-dependent synthetase and ligase
RY45_RS05190	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
RY45_RS05195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RY45_RS05210	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RY45_RS05215	COG2967	ApaG domain
RY45_RS05220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RY45_RS05225	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RY45_RS05235	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RY45_RS05240	COG3178	'Phosphotransferase
RY45_RS05245	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RY45_RS05250	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RY45_RS05255	COG2252	PERMEase
RY45_RS05265	COG0488	(ABC) transporter
RY45_RS05280	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RY45_RS05285	COG0741	lytic transglycosylase activity
RY45_RS05305	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
RY45_RS05310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RY45_RS05315	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
RY45_RS05340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RY45_RS05350	COG3721	Heme iron utilization protein
RY45_RS05355	COG0748	coenzyme F420 binding
RY45_RS05375	COG4771	TonB-dependent receptor
RY45_RS05380	COG2814	Major facilitator Superfamily
RY45_RS05385	COG3655	Transcriptional regulator
RY45_RS05395	COG2205	protein histidine kinase activity
RY45_RS05395	COG2202	Pas domain
RY45_RS05410	COG3397	chitin binding
RY45_RS05415	COG2226	methyltransferase
RY45_RS05425	COG1765	OsmC-like protein
RY45_RS05440	COG3954	Phosphoribulokinase
RY45_RS05445	COG2076	Multidrug Resistance protein
RY45_RS05450	COG2076	Multidrug Resistance protein
RY45_RS05455	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RY45_RS05460	COG0726	polysaccharide deacetylase
RY45_RS05465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RY45_RS05465	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RY45_RS05470	COG0463	Glycosyl transferase, family 2
RY45_RS05475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RY45_RS05485	COG3089	Belongs to the UPF0270 family
RY45_RS05490	COG2203	Gaf domain
RY45_RS05490	COG3706	GGDEF domain
RY45_RS05490	COG4251	negative regulation of phosphorylation
RY45_RS05490	COG5001	Diguanylate cyclase
RY45_RS05495	COG0429	hydrolase of the alpha beta-hydrolase fold
RY45_RS05500	COG0784	Response regulator, receiver
RY45_RS05500	COG0835	chemotaxis
RY45_RS05510	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
RY45_RS05515	COG1047	Peptidyl-prolyl cis-trans
RY45_RS05530	COG0545	Peptidyl-prolyl cis-trans isomerase
RY45_RS05535	COG2204	response regulator
RY45_RS05555	COG0737	Belongs to the 5'-nucleotidase family
RY45_RS05560	COG2200	EAL domain
RY45_RS05570	COG0305	Participates in initiation and elongation during chromosome replication
RY45_RS05575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RY45_RS05580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RY45_RS05585	COG0826	peptidase U32
RY45_RS05590	COG2199	diguanylate cyclase activity
RY45_RS05590	COG2200	EAL domain
RY45_RS05590	COG2203	Gaf domain
RY45_RS05610	COG2197	response regulator
RY45_RS05640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RY45_RS05645	COG2201	protein-glutamate methylesterase activity
RY45_RS05650	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
RY45_RS05660	COG0840	transmembrane signaling receptor activity
RY45_RS05665	COG0835	chemotaxis
RY45_RS05675	COG2198	Histidine kinase
RY45_RS05675	COG0643	Histidine kinase
RY45_RS05690	COG0840	transmembrane signaling receptor activity
RY45_RS05695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RY45_RS05705	COG1280	lysine exporter protein (LysE YggA)
RY45_RS05710	COG0826	peptidase U32
RY45_RS05720	COG3813	Protein conserved in bacteria
RY45_RS05745	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
RY45_RS05765	COG0300	oxidoreductase activity
RY45_RS05775	COG0840	transmembrane signaling receptor activity
RY45_RS05785	COG0235	Class ii aldolase
RY45_RS05790	COG1454	alcohol dehydrogenase
RY45_RS05805	COG1070	Carbohydrate kinase
RY45_RS05810	COG4806	L-rhamnose isomerase
RY45_RS05820	COG3254	rhamnose metabolic process
RY45_RS05845	COG0077	Prephenate dehydratase
RY45_RS05845	COG1605	Chorismate mutase
RY45_RS05875	COG3272	Protein of unknown function (DUF1722)
RY45_RS05880	COG0789	Transcriptional regulator
RY45_RS05885	COG0415	Belongs to the DNA photolyase family
RY45_RS05895	COG4221	oxidoreductase activity
RY45_RS05910	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RY45_RS05935	COG0783	Belongs to the Dps family
RY45_RS05940	COG1151	hydroxylamine reductase activity
RY45_RS05950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RY45_RS05955	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RY45_RS05955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RY45_RS05965	COG2831	hemolysin activation secretion protein
RY45_RS05980	COG3210	domain, Protein
RY45_RS06015	COG2771	luxR family
RY45_RS06030	COG4104	PAAR repeat-containing protein
RY45_RS06065	COG0693	protein deglycase activity
RY45_RS06070	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RY45_RS06075	COG1666	GTP binding
RY45_RS06080	COG3248	Nucleoside-binding outer membrane protein
RY45_RS06085	COG2211	Major facilitator Superfamily
RY45_RS06095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RY45_RS06105	COG2813	Specifically methylates the guanine in position
RY45_RS06110	COG0271	Belongs to the BolA IbaG family
RY45_RS06115	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
RY45_RS06120	COG1805	sodium ion transport
RY45_RS06125	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
RY45_RS06130	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
RY45_RS06135	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
RY45_RS06140	COG2871	sodium ion transport
RY45_RS06145	COG1477	protein flavinylation
RY45_RS06160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RY45_RS06165	COG0840	transmembrane signaling receptor activity
RY45_RS06170	COG0583	DNA-binding transcription factor activity
RY45_RS06180	COG2363	Small membrane protein
RY45_RS06185	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
RY45_RS06195	COG0473	3-isopropylmalate dehydrogenase activity
RY45_RS06200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RY45_RS06205	COG1611	Belongs to the LOG family
RY45_RS06220	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RY45_RS06220	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RY45_RS06230	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
RY45_RS06255	COG3098	single-species biofilm formation
RY45_RS06260	COG0564	pseudouridine synthase activity
RY45_RS06270	COG4580	involved in the transport of maltose and maltodextrins
RY45_RS06280	COG1263	PTS System
RY45_RS06280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RY45_RS06290	COG2171	N-acyltransferase activity
RY45_RS06295	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RY45_RS06300	COG0024	Methionine aminopeptidase
RY45_RS06305	COG0052	Belongs to the universal ribosomal protein uS2 family
RY45_RS06310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RY45_RS06315	COG0528	UMP kinase activity
RY45_RS06320	COG0233	cytoplasmic translational termination
RY45_RS06325	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RY45_RS06330	COG0575	Belongs to the CDS family
RY45_RS06335	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RY45_RS06340	COG0750	zinc metalloprotease
RY45_RS06355	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RY45_RS06360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RY45_RS06365	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RY45_RS06370	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RY45_RS06375	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RY45_RS06385	COG0825	malonyl-CoA metabolic process
RY45_RS06390	COG3710	Transcriptional regulator
RY45_RS06395	COG0531	amino acid
RY45_RS06400	COG1982	Orn Lys Arg decarboxylase major
RY45_RS06405	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RY45_RS06420	COG0814	amino acid
RY45_RS06425	COG1234	tRNA 3'-trailer cleavage
RY45_RS06435	COG1073	alpha beta
RY45_RS06440	COG1073	alpha beta
RY45_RS06450	COG0531	amino acid
RY45_RS06460	COG0488	(ABC) transporter
RY45_RS06470	COG3590	peptidase
RY45_RS06475	COG0037	tRNA processing
RY45_RS06480	COG3706	GGDEF domain
RY45_RS06515	COG0366	Alpha amylase catalytic
RY45_RS06530	COG0463	Glycosyl transferase, family 2
RY45_RS06545	COG2989	Protein conserved in bacteria
RY45_RS06550	COG3108	Peptidase M15
RY45_RS06560	COG2860	membrane
RY45_RS06575	COG3115	cell septum assembly
RY45_RS06580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RY45_RS06590	COG1328	CTP reductase activity
RY45_RS06595	COG0602	queuosine metabolic process
RY45_RS06625	COG1566	PFAM secretion protein HlyD family protein
RY45_RS06630	COG1846	Transcriptional regulator
RY45_RS06640	COG0281	malic enzyme
RY45_RS06645	COG3290	protein histidine kinase activity
RY45_RS06650	COG4565	transcriptional regulatory protein
RY45_RS06655	COG0697	spore germination
RY45_RS06670	COG3284	Transcriptional regulator
RY45_RS06675	COG1960	acyl-CoA dehydrogenase activity
RY45_RS06680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RY45_RS06685	COG0346	lactoylglutathione lyase activity
RY45_RS06690	COG0745	RESPONSE REGULATOR receiver
RY45_RS06695	COG5002	protein histidine kinase activity
RY45_RS06720	COG3142	Participates in the control of copper homeostasis
RY45_RS06730	COG0545	Peptidyl-prolyl cis-trans isomerase
RY45_RS06735	COG1131	(ABC) transporter
RY45_RS06750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RY45_RS06755	COG4597	amino acid ABC transporter
RY45_RS06760	COG0765	amino acid transport
RY45_RS06765	COG1126	abc transporter atp-binding protein
RY45_RS06775	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
RY45_RS06785	COG0678	peroxiredoxin activity
RY45_RS06795	COG0019	diaminopimelate decarboxylase activity
RY45_RS06800	COG1115	amino acid carrier protein
RY45_RS06805	COG2831	hemolysin activation secretion protein
RY45_RS06810	COG3210	domain, Protein
RY45_RS06815	COG3210	domain, Protein
RY45_RS06825	COG0095	Lipoate-protein ligase
RY45_RS06830	COG2233	PERMEase
RY45_RS06845	COG0534	Mate efflux family protein
RY45_RS06855	COG0281	malic enzyme
RY45_RS06885	COG0733	neurotransmitter:sodium symporter activity
RY45_RS06890	COG1752	Esterase of the alpha-beta hydrolase superfamily
RY45_RS06900	COG1566	PFAM secretion protein HlyD family protein
RY45_RS06905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RY45_RS06915	COG1032	radical SAM domain protein
RY45_RS06935	COG0673	inositol 2-dehydrogenase activity
RY45_RS06945	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RY45_RS06950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RY45_RS06955	COG0739	heme binding
RY45_RS06955	COG1196	nuclear chromosome segregation
RY45_RS06955	COG0741	lytic transglycosylase activity
RY45_RS06960	COG0366	Alpha amylase catalytic
RY45_RS06980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RY45_RS06990	COG0788	formyltetrahydrofolate deformylase activity
RY45_RS06995	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RY45_RS07005	COG3118	belongs to the thioredoxin family
RY45_RS07010	COG2091	lysine biosynthetic process via aminoadipic acid
RY45_RS07015	COG0791	NLP P60 protein
RY45_RS07020	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
RY45_RS07035	COG1388	LysM domain
RY45_RS07035	COG1376	ErfK ybiS ycfS ynhG family protein
RY45_RS07045	COG0583	DNA-binding transcription factor activity
RY45_RS07050	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RY45_RS07055	COG0243	molybdopterin cofactor binding
RY45_RS07105	COG1136	(ABC) transporter
RY45_RS07115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RY45_RS07125	COG2801	Transposase and inactivated derivatives
RY45_RS07135	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RY45_RS07145	COG1960	acyl-CoA dehydrogenase activity
RY45_RS07150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RY45_RS07160	COG0469	pyruvate kinase activity
RY45_RS07165	COG1737	Transcriptional regulator
RY45_RS07185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RY45_RS07200	COG1677	Flagellar hook-basal body complex protein FliE
RY45_RS07210	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RY45_RS07265	COG1684	flagellar biosynthetic protein fliR
RY45_RS07275	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RY45_RS07300	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
RY45_RS07305	COG0643	Histidine kinase
RY45_RS07305	COG0784	Response regulator, receiver
RY45_RS07305	COG2198	Histidine kinase
RY45_RS07310	COG2201	protein-glutamate methylesterase activity
RY45_RS07315	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RY45_RS07320	COG1360	Flagellar Motor Protein
RY45_RS07325	COG1192	Involved in chromosome partitioning
RY45_RS07335	COG0835	chemotaxis
RY45_RS07350	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RY45_RS07355	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RY45_RS07360	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RY45_RS07365	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
RY45_RS07370	COG1138	Cytochrome C-type biogenesis protein
RY45_RS07375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RY45_RS07380	COG4235	cytochrome complex assembly
RY45_RS07380	COG3088	subunit of a heme lyase
RY45_RS07385	COG4235	cytochrome complex assembly
RY45_RS07385	COG3088	subunit of a heme lyase
RY45_RS07400	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RY45_RS07405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RY45_RS07405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RY45_RS07420	COG0259	pyridoxamine-phosphate oxidase activity
RY45_RS07425	COG0625	glutathione transferase activity
RY45_RS07435	COG3153	acetyltransferase
RY45_RS07450	COG2850	peptidyl-arginine hydroxylation
RY45_RS07455	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RY45_RS07460	COG2915	High frequency lysogenization protein hflD homolog
RY45_RS07465	COG0482	sulfurtransferase activity
RY45_RS07475	COG1187	pseudouridine synthase activity
RY45_RS07485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RY45_RS07485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RY45_RS07485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RY45_RS07500	COG5599	Phosphatase
RY45_RS07505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RY45_RS07505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RY45_RS07505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RY45_RS07520	COG4821	SIS domain
RY45_RS07530	COG0789	Transcriptional regulator
RY45_RS07540	COG1609	Transcriptional regulator
RY45_RS07545	COG1263	PTS System
RY45_RS07545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RY45_RS07550	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RY45_RS07565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RY45_RS07580	COG2207	Transcriptional regulator
RY45_RS07585	COG0538	isocitrate dehydrogenase activity
RY45_RS07590	COG3048	D-serine ammonia-lyase activity
RY45_RS07595	COG2610	gluconate transmembrane transporter activity
RY45_RS07600	COG0583	DNA-binding transcription factor activity
RY45_RS07610	COG3171	Protein conserved in bacteria
RY45_RS07625	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
RY45_RS07630	COG1715	Restriction endonuclease
RY45_RS07695	COG2974	May be involved in recombination
RY45_RS07725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RY45_RS07970	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RY45_RS07975	COG2867	negative regulation of translational initiation
RY45_RS07980	COG2914	Belongs to the UPF0125 (RnfH) family
RY45_RS07985	COG0702	epimerase
RY45_RS07990	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RY45_RS07995	COG1454	alcohol dehydrogenase
RY45_RS08035	COG1280	lysine exporter protein (LysE YggA)
RY45_RS08045	COG3263	regulation of cellular component size
RY45_RS08055	COG3263	regulation of cellular component size
RY45_RS08060	COG1876	peptidase activity
RY45_RS08065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RY45_RS08070	COG1393	Belongs to the ArsC family
RY45_RS08075	COG0583	DNA-binding transcription factor activity
RY45_RS08085	COG3069	C4-dicarboxylate transmembrane transporter activity
RY45_RS08100	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RY45_RS08105	COG0017	Asparaginyl-tRNA synthetase
RY45_RS08125	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RY45_RS08130	COG0156	8-amino-7-oxononanoate synthase activity
RY45_RS08135	COG2226	methyltransferase
RY45_RS08135	COG1073	alpha beta
RY45_RS08140	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RY45_RS08145	COG0501	Belongs to the peptidase M48B family
RY45_RS08155	COG3217	Mosc domain protein beta barrel domain protein
RY45_RS08155	COG0633	Ferredoxin
RY45_RS08155	COG3217	Mosc domain protein beta barrel domain protein
RY45_RS08155	COG0633	Ferredoxin
RY45_RS08165	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RY45_RS08165	COG1013	pyruvate-flavodoxin oxidoreductase activity
RY45_RS08165	COG0674	pyruvate-flavodoxin oxidoreductase activity
RY45_RS08165	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RY45_RS08180	COG0534	Mate efflux family protein
RY45_RS08220	COG1309	transcriptional regulator
RY45_RS08235	COG0791	NLP P60 protein
RY45_RS08245	COG0583	DNA-binding transcription factor activity
RY45_RS08250	COG0450	alkyl hydroperoxide reductase
RY45_RS08270	COG0500	methyltransferase
RY45_RS08275	COG4106	trans-aconitate 2-methyltransferase activity
RY45_RS08280	COG1801	Protein of unknown function DUF72
RY45_RS08285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RY45_RS08290	COG0217	transcriptional regulatory protein
RY45_RS08295	COG2194	sulfuric ester hydrolase activity
RY45_RS08300	COG1846	Transcriptional regulator
RY45_RS08300	COG1940	carbohydrate kinase activity
RY45_RS08305	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RY45_RS08310	COG0363	glucosamine-6-phosphate deaminase activity
RY45_RS08315	COG2190	(PTS) system
RY45_RS08315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RY45_RS08315	COG1263	PTS System
RY45_RS08325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RY45_RS08330	COG0735	belongs to the Fur family
RY45_RS08340	COG0716	FMN binding
RY45_RS08355	COG0596	Alpha beta hydrolase
RY45_RS08360	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
RY45_RS08365	COG0033	Phosphoglucomutase
RY45_RS08375	COG1846	Transcriptional regulator
RY45_RS08390	COG2951	lytic endotransglycosylase activity
RY45_RS08395	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RY45_RS08400	COG4136	ATPase activity
RY45_RS08410	COG4134	Bacterial extracellular solute-binding protein
RY45_RS08420	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RY45_RS08430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RY45_RS08435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RY45_RS08445	COG0729	surface antigen
RY45_RS08450	COG2911	Protein conserved in bacteria
RY45_RS08470	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RY45_RS08480	COG0741	lytic transglycosylase activity
RY45_RS08495	COG1607	acyl-coa hydrolase
RY45_RS08505	COG3021	interspecies interaction between organisms
RY45_RS08510	COG0741	lytic transglycosylase activity
RY45_RS08510	COG1388	LysM domain
RY45_RS08515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RY45_RS08520	COG2226	methyltransferase
RY45_RS08525	COG0328	RNA-DNA hybrid ribonuclease activity
RY45_RS08545	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RY45_RS08550	COG2716	regulation of RNA biosynthetic process
RY45_RS08575	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RY45_RS08580	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RY45_RS08585	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RY45_RS08590	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RY45_RS08610	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RY45_RS08620	COG0590	tRNA wobble adenosine to inosine editing
RY45_RS08625	COG0573	inorganic phosphate transmembrane transporter activity
RY45_RS08635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RY45_RS08640	COG0704	Plays a role in the regulation of phosphate uptake
RY45_RS08660	COG1253	flavin adenine dinucleotide binding
RY45_RS08675	COG0531	amino acid
RY45_RS08690	COG1126	abc transporter atp-binding protein
RY45_RS08695	COG0765	amino acid transport
RY45_RS08700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RY45_RS08705	COG3706	GGDEF domain
RY45_RS08710	COG2271	Major facilitator Superfamily
RY45_RS08725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RY45_RS08755	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
RY45_RS08760	COG0477	Major facilitator Superfamily
RY45_RS08765	COG0123	including yeast histone deacetylase and acetoin utilization protein
RY45_RS08775	COG1199	ATP-dependent helicase activity
RY45_RS08790	COG1448	Aminotransferase
RY45_RS08805	COG0302	gtp cyclohydrolase
RY45_RS08810	COG0840	transmembrane signaling receptor activity
RY45_RS08815	COG2759	Belongs to the formate--tetrahydrofolate ligase family
RY45_RS08825	COG0583	DNA-binding transcription factor activity
RY45_RS08855	COG2195	Cleaves the N-terminal amino acid of tripeptides
RY45_RS08865	COG1166	arginine decarboxylase activity
RY45_RS08885	COG0814	amino acid
RY45_RS08895	COG3681	Belongs to the UPF0597 family
RY45_RS08910	COG1403	HNH endonuclease
RY45_RS08920	COG0346	lactoylglutathione lyase activity
RY45_RS08935	COG1187	pseudouridine synthase activity
RY45_RS08940	COG2807	transmembrane transport
RY45_RS08950	COG0583	DNA-binding transcription factor activity
RY45_RS08955	COG2271	Major facilitator Superfamily
RY45_RS08980	COG2979	Protein of unknown function (DUF533)
RY45_RS08985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RY45_RS08995	COG1294	oxidase, subunit
RY45_RS09005	COG2814	Major facilitator Superfamily
RY45_RS09010	COG0656	L-ascorbic acid biosynthetic process
RY45_RS09030	COG0583	DNA-binding transcription factor activity
RY45_RS09035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RY45_RS09040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RY45_RS09045	COG2271	Major facilitator Superfamily
RY45_RS09050	COG1349	DNA-binding transcription factor activity
RY45_RS09060	COG0584	glycerophosphoryl diester phosphodiesterase
RY45_RS09070	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RY45_RS09075	COG1605	Chorismate mutase
RY45_RS09075	COG0287	Prephenate dehydrogenase
RY45_RS09080	COG0583	DNA-binding transcription factor activity
RY45_RS09085	COG3085	chromosome segregation
RY45_RS09090	COG4574	serine-type endopeptidase inhibitor activity
RY45_RS09110	COG1770	oligopeptidase
RY45_RS09115	COG4771	TonB-dependent receptor
RY45_RS09120	COG3083	sulfuric ester hydrolase activity
RY45_RS09125	COG3082	Protein of unknown function (DUF1414)
RY45_RS09130	COG3081	Nucleoid-associated protein
RY45_RS09140	COG1175	transmembrane transport
RY45_RS09145	COG3833	ABC-type maltose transport systems, permease component
RY45_RS09150	COG3842	ATPase activity
RY45_RS09175	COG0425	Belongs to the sulfur carrier protein TusA family
RY45_RS09180	COG4783	chaperone-mediated protein folding
RY45_RS09190	COG1393	Belongs to the ArsC family
RY45_RS09205	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
RY45_RS09210	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RY45_RS09215	COG2431	L-lysine efflux transmembrane transporter activity
RY45_RS09225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RY45_RS09245	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RY45_RS09255	COG0446	pyridine nucleotide-disulphide oxidoreductase
RY45_RS09260	COG2373	Large extracellular alpha-helical protein
RY45_RS09265	COG4953	penicillin-binding protein 1C
RY45_RS09275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RY45_RS09275	COG0301	tRNA thio-modification
RY45_RS09290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RY45_RS09335	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RY45_RS09355	COG0483	inositol monophosphate 1-phosphatase activity
RY45_RS09365	COG0625	glutathione transferase activity
RY45_RS09370	COG2814	Major facilitator Superfamily
RY45_RS09385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RY45_RS09390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RY45_RS09395	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RY45_RS09400	COG0509	glycine decarboxylation via glycine cleavage system
RY45_RS09405	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RY45_RS09405	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RY45_RS09435	COG0798	PFAM Bile acid sodium symporter
RY45_RS09440	COG1393	Belongs to the ArsC family
RY45_RS09455	COG0477	Major facilitator Superfamily
RY45_RS09460	COG3634	alkyl hydroperoxide reductase activity
RY45_RS09470	COG0517	IMP dehydrogenase activity
RY45_RS09475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RY45_RS09480	COG0343	queuine tRNA-ribosyltransferase activity
RY45_RS09485	COG1862	Preprotein translocase
RY45_RS09490	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RY45_RS09495	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RY45_RS09510	COG0826	peptidase U32
RY45_RS09515	COG0826	peptidase U32
RY45_RS09520	COG3154	lipid carrier protein
RY45_RS09540	COG1104	cysteine desulfurase activity
RY45_RS09545	COG0822	iron-sulfur transferase activity
RY45_RS09555	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RY45_RS09560	COG0443	Heat shock 70 kDa protein
RY45_RS09565	COG0633	Ferredoxin
RY45_RS09575	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RY45_RS09580	COG0105	UTP biosynthetic process
RY45_RS09585	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RY45_RS09605	COG0124	histidyl-tRNA synthetase
RY45_RS09610	COG2976	Protein conserved in bacteria
RY45_RS09615	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RY45_RS09620	COG1160	GTP binding
RY45_RS09625	COG1645	bacterial-type flagellum-dependent swarming motility
RY45_RS09630	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
RY45_RS09635	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RY45_RS09635	COG0047	phosphoribosylformylglycinamidine synthase activity
RY45_RS09640	COG2199	diguanylate cyclase activity
RY45_RS09640	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
RY45_RS09655	COG1007	ATP synthesis coupled electron transport
RY45_RS09660	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RY45_RS09670	COG0713	ATP synthesis coupled electron transport
RY45_RS09675	COG0839	Belongs to the complex I subunit 6 family
RY45_RS09680	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RY45_RS09685	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RY45_RS09690	COG1034	ATP synthesis coupled electron transport
RY45_RS09705	COG0649	NAD binding
RY45_RS09705	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RY45_RS09710	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RY45_RS09715	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RY45_RS09720	COG1360	Flagellar Motor Protein
RY45_RS09725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RY45_RS09740	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
RY45_RS09760	COG0724	RNA recognition motif
RY45_RS09765	COG4989	oxidoreductase activity
RY45_RS09790	COG3437	response regulator, receiver
RY45_RS09795	COG0583	DNA-binding transcription factor activity
RY45_RS09805	COG3300	MHYT domain
RY45_RS09805	COG5001	Diguanylate cyclase
RY45_RS09810	COG0778	Nitroreductase
RY45_RS09830	COG0583	DNA-binding transcription factor activity
RY45_RS09840	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RY45_RS09845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RY45_RS09850	COG0539	negative regulation of cytoplasmic translation
RY45_RS09855	COG0776	regulation of translation
RY45_RS09865	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
RY45_RS09885	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RY45_RS09890	COG0602	queuosine metabolic process
RY45_RS09895	COG3530	Putative quorum-sensing-regulated virulence factor
RY45_RS09900	COG2096	Adenosyltransferase
RY45_RS09905	COG2916	Histone family protein nucleoid-structuring protein H-NS
RY45_RS09910	COG1757	Na H antiporter
RY45_RS09915	COG1435	thymidine kinase activity
RY45_RS09980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RY45_RS09985	COG1278	Cold shock
RY45_RS09990	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RY45_RS09995	COG0542	response to heat
RY45_RS10000	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RY45_RS10005	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RY45_RS10010	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RY45_RS10015	COG3134	Outer membrane lipoprotein
RY45_RS10020	COG3706	GGDEF domain
RY45_RS10025	COG0492	ferredoxin-NADP+ reductase activity
RY45_RS10035	COG0531	amino acid
RY45_RS10035	COG1674	ftsk spoiiie
RY45_RS10040	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RY45_RS10045	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RY45_RS10055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RY45_RS10060	COG1286	toxin biosynthetic process
RY45_RS10065	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RY45_RS10075	COG4172	Belongs to the ABC transporter superfamily
RY45_RS10085	COG4171	peptide transport system, permease
RY45_RS10090	COG4168	peptide transport system, permease
RY45_RS10100	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
RY45_RS10105	COG1842	Phage shock protein A
RY45_RS10120	COG3106	COG3106 Predicted ATPase
RY45_RS10125	COG3768	UPF0283 membrane protein
RY45_RS10135	COG2154	pterin-4-alpha-carbinolamine dehydratase
RY45_RS10150	COG2199	diguanylate cyclase activity
RY45_RS10155	COG2885	chlorophyll binding
RY45_RS10160	COG0861	Integral membrane protein TerC family
RY45_RS10175	COG1022	Amp-dependent synthetase and ligase
RY45_RS10180	COG0295	cytidine deaminase activity
RY45_RS10185	COG1346	cytolysis
RY45_RS10190	COG1380	Effector of murein hydrolase LrgA
RY45_RS10195	COG3345	alpha-galactosidase
RY45_RS10205	COG2925	Exonuclease
RY45_RS10210	COG2160	L-arabinose isomerase activity
RY45_RS10220	COG1069	ribulokinase activity
RY45_RS10225	COG1879	ABC-type sugar transport system periplasmic component
RY45_RS10235	COG1172	Belongs to the binding-protein-dependent transport system permease family
RY45_RS10245	COG0583	DNA-binding transcription factor activity
RY45_RS10255	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RY45_RS10260	COG0254	rRNA binding
RY45_RS10275	COG1451	nucleotide metabolic process
RY45_RS10290	COG3069	C4-dicarboxylate transmembrane transporter activity
RY45_RS10300	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
RY45_RS10300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RY45_RS10305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RY45_RS10330	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RY45_RS10335	COG1053	succinate dehydrogenase
RY45_RS10345	COG0567	Dehydrogenase, E1 component
RY45_RS10350	COG0508	dehydrogenase complex catalyzes the overall conversion of
RY45_RS10355	COG0045	succinate-CoA ligase (ADP-forming) activity
RY45_RS10360	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RY45_RS10370	COG2983	Belongs to the UPF0260 family
RY45_RS10375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RY45_RS10385	COG3842	ATPase activity
RY45_RS10390	COG1840	ABC-type Fe3 transport system, periplasmic component
RY45_RS10400	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RY45_RS10405	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RY45_RS10410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RY45_RS10415	COG1882	Formate acetyltransferase
RY45_RS10420	COG2116	formate transmembrane transporter activity
RY45_RS10425	COG1944	ATP diphosphatase activity
RY45_RS10435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RY45_RS10440	COG0612	Peptidase, M16
RY45_RS10455	COG2910	NAD(P)H-binding
RY45_RS10460	COG0583	DNA-binding transcription factor activity
RY45_RS10470	COG4977	sequence-specific DNA binding
RY45_RS10475	COG4774	siderophore transport
RY45_RS10485	COG0583	DNA-binding transcription factor activity
RY45_RS10490	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RY45_RS10500	COG0516	GMP reductase activity
RY45_RS10500	COG0517	IMP dehydrogenase activity
RY45_RS10515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RY45_RS10520	COG3046	protein related to deoxyribodipyrimidine photolyase
RY45_RS10525	COG3033	Beta-eliminating lyase
RY45_RS10535	COG1051	belongs to the nudix hydrolase family
RY45_RS10540	COG3088	subunit of a heme lyase
RY45_RS10540	COG4235	cytochrome complex assembly
RY45_RS10545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RY45_RS10555	COG3301	Polysulphide reductase, NrfD
RY45_RS10560	COG0437	4 iron, 4 sulfur cluster binding
RY45_RS10565	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
RY45_RS10580	COG0247	lactate metabolic process
RY45_RS10585	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
RY45_RS10590	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RY45_RS10595	COG3012	SEC-C Motif Domain Protein
RY45_RS10600	COG0840	transmembrane signaling receptor activity
RY45_RS10605	COG1940	carbohydrate kinase activity
RY45_RS10605	COG1846	Transcriptional regulator
RY45_RS10610	COG3290	protein histidine kinase activity
RY45_RS10615	COG4565	transcriptional regulatory protein
RY45_RS10635	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
RY45_RS10640	COG2985	domain, Protein
RY45_RS10640	COG0569	domain protein
RY45_RS10650	COG0556	nucleotide-excision repair
RY45_RS10660	COG0586	Pfam SNARE associated Golgi protein
RY45_RS10665	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RY45_RS10670	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RY45_RS10675	COG2186	Transcriptional regulator
RY45_RS10680	COG2719	SpoVR family
RY45_RS10690	COG2766	serine protein kinase
RY45_RS10695	COG0514	ATP-dependent DNA helicase (RecQ)
RY45_RS10700	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
RY45_RS10705	COG0814	amino acid
RY45_RS10740	COG0058	SHG alpha-glucan phosphorylase activity
RY45_RS10745	COG0471	metal ion transport
RY45_RS10750	COG3118	belongs to the thioredoxin family
RY45_RS10760	COG1132	(ABC) transporter
RY45_RS10765	COG1132	(ABC) transporter
RY45_RS10775	COG2501	S4 domain
RY45_RS10785	COG3243	poly(R)-hydroxyalkanoic acid synthase
RY45_RS10805	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RY45_RS10810	COG2329	Antibiotic biosynthesis monooxygenase
RY45_RS10840	COG1742	UPF0060 membrane protein
RY45_RS10855	COG0513	Belongs to the DEAD box helicase family
RY45_RS10860	COG0386	Belongs to the glutathione peroxidase family
RY45_RS10870	COG1181	Belongs to the D-alanine--D-alanine ligase family
RY45_RS10880	COG3148	PFAM DTW domain containing protein
RY45_RS10885	COG0730	response to heat
RY45_RS10890	COG0583	DNA-binding transcription factor activity
RY45_RS10905	COG3593	DNA synthesis involved in DNA repair
RY45_RS10945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RY45_RS10950	COG1011	Hydrolase
RY45_RS10955	COG1473	amidohydrolase
RY45_RS10960	COG0205	6-phosphofructokinase activity
RY45_RS10970	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RY45_RS10975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RY45_RS10985	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
RY45_RS10990	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
RY45_RS11010	COG0242	peptide deformylase activity
RY45_RS11040	COG0384	phenazine biosynthesis protein PhzF
RY45_RS11050	COG2824	Alkylphosphonate utilization operon protein PhnA
RY45_RS11080	COG3706	GGDEF domain
RY45_RS11090	COG2840	Smr protein MutS2
RY45_RS11095	COG2890	protein-(glutamine-N5) methyltransferase activity
RY45_RS11100	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RY45_RS11110	COG0513	Belongs to the DEAD box helicase family
RY45_RS11115	COG5654	RES domain protein
RY45_RS11125	COG0814	amino acid
RY45_RS11130	COG1609	Transcriptional regulator
RY45_RS11135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RY45_RS11135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RY45_RS11140	COG1105	Belongs to the carbohydrate kinase PfkB family
RY45_RS11145	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
RY45_RS11145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RY45_RS11145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RY45_RS11150	COG2140	Oxalate decarboxylase
RY45_RS11155	COG1609	Transcriptional regulator
RY45_RS11170	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RY45_RS11170	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RY45_RS11175	COG3715	PTS system
RY45_RS11180	COG3716	PTS system mannose fructose sorbose family IID component
RY45_RS11190	COG3313	Fe-S protein
RY45_RS11195	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
RY45_RS11200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RY45_RS11205	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RY45_RS11210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RY45_RS11220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RY45_RS11240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RY45_RS11245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RY45_RS11250	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RY45_RS11255	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RY45_RS11260	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RY45_RS11265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RY45_RS11265	COG0072	phenylalanine-tRNA ligase activity
RY45_RS11270	COG0776	regulation of translation
RY45_RS11300	COG5001	Diguanylate cyclase
RY45_RS11300	COG3300	MHYT domain
RY45_RS11305	COG1609	Transcriptional regulator
RY45_RS11310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RY45_RS11315	COG1879	ABC-type sugar transport system periplasmic component
RY45_RS11320	COG1172	Belongs to the binding-protein-dependent transport system permease family
RY45_RS11325	COG1129	ABC transporter
RY45_RS11330	COG1869	D-ribose catabolic process
RY45_RS11350	COG0037	tRNA processing
RY45_RS11355	COG0589	response to stress
RY45_RS11360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RY45_RS11385	COG2010	Cytochrome c
RY45_RS11400	COG3278	Belongs to the heme-copper respiratory oxidase family
RY45_RS11410	COG1956	GAF domain-containing protein
RY45_RS11415	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
RY45_RS11425	COG0308	aminopeptidase N
RY45_RS11435	COG2902	Dehydrogenase
RY45_RS11440	COG0167	dihydroorotate dehydrogenase activity
RY45_RS11450	COG0116	Belongs to the methyltransferase superfamily
RY45_RS11450	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RY45_RS11460	COG0488	(ABC) transporter
RY45_RS11470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RY45_RS11475	COG1067	ATP-dependent peptidase activity
RY45_RS11485	COG3141	response to X-ray
RY45_RS11495	COG4221	oxidoreductase activity
RY45_RS11540	COG0372	Belongs to the citrate synthase family
RY45_RS11545	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
RY45_RS11555	COG2995	paraquat-inducible protein a
RY45_RS11560	COG3008	intermembrane lipid transfer
RY45_RS11565	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
RY45_RS11565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RY45_RS11580	COG0084	hydrolase, TatD family'
RY45_RS11585	COG0470	DNA polymerase III
RY45_RS11590	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RY45_RS11595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RY45_RS11600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RY45_RS11610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RY45_RS11615	COG1028	Short-chain dehydrogenase reductase Sdr
RY45_RS11625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RY45_RS11630	COG0416	fatty acid biosynthetic process
RY45_RS11635	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RY45_RS11640	COG1399	metal-binding, possibly nucleic acid-binding protein
RY45_RS11655	COG2814	Major facilitator Superfamily
RY45_RS11660	COG0424	maF-like protein
RY45_RS11665	COG0546	phosphoglycolate phosphatase activity
RY45_RS11670	COG0564	pseudouridine synthase activity
RY45_RS11675	COG1530	ribonuclease E activity
RY45_RS11680	COG0306	phosphate transporter
RY45_RS11685	COG0717	Belongs to the dCTP deaminase family
RY45_RS11690	COG0572	uridine kinase
RY45_RS11695	COG0489	protein tyrosine kinase activity
RY45_RS11700	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RY45_RS11700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RY45_RS11705	COG0625	glutathione transferase activity
RY45_RS11710	COG1254	Belongs to the acylphosphatase family
RY45_RS11720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RY45_RS11740	COG0709	Synthesizes selenophosphate from selenide and ATP
RY45_RS11745	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
RY45_RS11750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RY45_RS11755	COG3437	response regulator, receiver
RY45_RS11765	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RY45_RS11775	COG1643	Atp-dependent helicase
RY45_RS11780	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
RY45_RS11780	COG0617	tRNA 3'-terminal CCA addition
RY45_RS11780	COG0517	IMP dehydrogenase activity
RY45_RS11795	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RY45_RS11805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RY45_RS11810	COG2832	Protein of unknown function (DUF454)
RY45_RS11815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RY45_RS11830	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
RY45_RS11835	COG0318	PFAM AMP-dependent synthetase and ligase
RY45_RS11840	COG0596	Alpha beta hydrolase
RY45_RS11840	COG2226	methyltransferase
RY45_RS11840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RY45_RS11850	COG1214	PFAM Peptidase M22, glycoprotease
RY45_RS11855	COG1199	ATP-dependent helicase activity
RY45_RS11865	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RY45_RS11870	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RY45_RS11875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RY45_RS11880	COG0131	Imidazoleglycerol-phosphate dehydratase
RY45_RS11880	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RY45_RS11885	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RY45_RS11890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RY45_RS11895	COG3437	response regulator, receiver
RY45_RS11900	COG2199	diguanylate cyclase activity
RY45_RS11905	COG2205	protein histidine kinase activity
RY45_RS11905	COG2198	Histidine kinase
RY45_RS11905	COG0784	Response regulator, receiver
RY45_RS11910	COG0107	imidazoleglycerol-phosphate synthase activity
RY45_RS11915	COG0140	phosphoribosyl-ATP diphosphatase activity
RY45_RS11915	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RY45_RS11930	COG0318	PFAM AMP-dependent synthetase and ligase
RY45_RS11935	COG1288	antiporter activity
RY45_RS11945	COG3134	Outer membrane lipoprotein
RY45_RS11955	COG2080	2 iron, 2 sulfur cluster binding
RY45_RS11960	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RY45_RS11965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RY45_RS11970	COG2252	PERMEase
RY45_RS11975	COG0402	S-adenosylhomocysteine deaminase activity
RY45_RS11980	COG2233	PERMEase
RY45_RS11985	COG2080	2 iron, 2 sulfur cluster binding
RY45_RS11985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RY45_RS11990	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RY45_RS11995	COG0402	S-adenosylhomocysteine deaminase activity
RY45_RS12000	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RY45_RS12000	COG0493	'glutamate synthase
RY45_RS12010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RY45_RS12015	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
RY45_RS12015	COG3608	succinylglutamate desuccinylase aspartoacylase
RY45_RS12020	COG0697	spore germination
RY45_RS12025	COG0549	Belongs to the carbamate kinase family
RY45_RS12035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RY45_RS12040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RY45_RS12045	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RY45_RS12050	COG3829	transcription factor binding
RY45_RS12070	COG1024	Enoyl-CoA hydratase
RY45_RS12070	COG1250	3-hydroxyacyl-CoA dehydrogenase
RY45_RS12075	COG0183	Belongs to the thiolase family
RY45_RS12080	COG0714	Associated with various cellular activities
RY45_RS12110	COG1595	DNA-templated transcription, initiation
RY45_RS12125	COG2067	long-chain fatty acid transport protein
RY45_RS12130	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
RY45_RS12150	COG3123	guanosine phosphorylase activity
RY45_RS12155	COG1760	l-serine dehydratase
RY45_RS12160	COG1760	l-serine dehydratase
RY45_RS12165	COG2951	lytic endotransglycosylase activity
RY45_RS12170	COG3100	YcgL domain-containing protein
RY45_RS12175	COG0850	regulation of cytokinetic process
RY45_RS12180	COG2894	cell division
RY45_RS12185	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RY45_RS12190	COG3099	Belongs to the UPF0263 family
RY45_RS12195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RY45_RS12235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RY45_RS12240	COG0697	spore germination
RY45_RS12245	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
RY45_RS12250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RY45_RS12260	COG0307	riboflavin synthase, alpha
RY45_RS12270	COG0534	Mate efflux family protein
RY45_RS12300	COG0417	DNA replication proofreading
RY45_RS12325	COG1560	Kdo2-lipid A biosynthetic process
RY45_RS12330	COG1560	Kdo2-lipid A biosynthetic process
RY45_RS12340	COG0583	DNA-binding transcription factor activity
RY45_RS12345	COG0673	inositol 2-dehydrogenase activity
RY45_RS12350	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
RY45_RS12355	COG0583	DNA-binding transcription factor activity
RY45_RS12360	COG1028	Short-chain dehydrogenase reductase Sdr
RY45_RS12365	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
RY45_RS12375	COG3300	MHYT domain
RY45_RS12375	COG5001	Diguanylate cyclase
RY45_RS12380	COG2723	6-phospho-beta-galactosidase activity
RY45_RS12385	COG0583	DNA-binding transcription factor activity
RY45_RS12395	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RY45_RS12405	COG2003	Belongs to the UPF0758 family
RY45_RS12425	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
RY45_RS12450	COG0582	viral genome integration into host DNA
RY45_RS12455	COG0730	response to heat
RY45_RS12465	COG1028	Short-chain dehydrogenase reductase Sdr
RY45_RS12475	COG1024	Enoyl-CoA hydratase
RY45_RS12480	COG1024	Enoyl-CoA hydratase
RY45_RS12485	COG1960	acyl-CoA dehydrogenase activity
RY45_RS12495	COG1960	acyl-CoA dehydrogenase activity
RY45_RS12500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RY45_RS12535	COG1584	GPR1 FUN34 yaaH family protein
RY45_RS12550	COG1115	amino acid carrier protein
RY45_RS12575	COG1024	Enoyl-CoA hydratase
RY45_RS12590	COG3162	membrane
RY45_RS12595	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RY45_RS12600	COG0488	(ABC) transporter
RY45_RS12605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RY45_RS12615	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RY45_RS12620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RY45_RS12625	COG0740	serine-type endopeptidase activity
RY45_RS12630	COG0544	peptidyl-prolyl cis-trans isomerase activity
RY45_RS12640	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
RY45_RS12645	COG4591	ABC-type transport system involved in lipoprotein release permease component
RY45_RS12650	COG1136	(ABC) transporter
RY45_RS12655	COG4591	ABC-type transport system involved in lipoprotein release permease component
RY45_RS12665	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RY45_RS12670	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RY45_RS12675	COG4166	transmembrane transport
RY45_RS12680	COG0697	spore germination
RY45_RS12690	COG2062	phosphohistidine phosphatase, SixA
RY45_RS12730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RY45_RS12730	COG0519	Catalyzes the synthesis of GMP from XMP
RY45_RS12735	COG0517	IMP dehydrogenase activity
RY45_RS12735	COG0516	GMP reductase activity
RY45_RS12740	COG3158	transport of potassium into the cell
RY45_RS12760	COG0697	spore germination
RY45_RS12765	COG1570	exodeoxyribonuclease VII activity
RY45_RS12780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RY45_RS12785	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RY45_RS12790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RY45_RS12830	COG4771	TonB-dependent receptor
RY45_RS12835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RY45_RS12840	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RY45_RS12845	COG1120	ATPase activity
RY45_RS12855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RY45_RS12860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RY45_RS12870	COG1028	Short-chain dehydrogenase reductase Sdr
RY45_RS12875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RY45_RS12880	COG1535	isochorismatase
RY45_RS12880	COG3433	isochorismatase activity
RY45_RS12885	COG1021	2,3-dihydroxybenzoate-AMP ligase
RY45_RS12905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RY45_RS12910	COG5001	Diguanylate cyclase
RY45_RS12910	COG3300	MHYT domain
RY45_RS12925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RY45_RS12935	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RY45_RS12940	COG0563	adenylate kinase activity
RY45_RS12945	COG0326	Molecular chaperone. Has ATPase activity
RY45_RS12950	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RY45_RS12970	COG3383	formate dehydrogenase (NAD+) activity
RY45_RS12975	COG3383	formate dehydrogenase (NAD+) activity
RY45_RS12980	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RY45_RS12985	COG3158	transport of potassium into the cell
RY45_RS12990	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RY45_RS12995	COG0651	ATP synthesis coupled electron transport
RY45_RS13000	COG0650	Formate hydrogenlyase subunit 4
RY45_RS13005	COG3261	NADH dehydrogenase
RY45_RS13005	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
RY45_RS13010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RY45_RS13015	COG3260	NADH ubiquinone oxidoreductase 20
RY45_RS13025	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RY45_RS13030	COG1921	L-seryl-tRNASec selenium transferase activity
RY45_RS13040	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
RY45_RS13045	COG0298	carbon dioxide binding
RY45_RS13055	COG0309	Hydrogenase expression formation protein (HypE)
RY45_RS13060	COG0375	protein maturation
RY45_RS13065	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RY45_RS13070	COG3842	ATPase activity
RY45_RS13080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RY45_RS13095	COG1773	rubredoxin
RY45_RS13100	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RY45_RS13105	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
RY45_RS13110	COG5557	Pfam Polysulphide reductase, NrfD
RY45_RS13115	COG0437	4 iron, 4 sulfur cluster binding
RY45_RS13120	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
RY45_RS13125	COG0745	RESPONSE REGULATOR receiver
RY45_RS13135	COG2198	Histidine kinase
RY45_RS13135	COG0643	Histidine kinase
RY45_RS13140	COG3290	protein histidine kinase activity
RY45_RS13140	COG0840	transmembrane signaling receptor activity
RY45_RS13145	COG0835	chemotaxis
RY45_RS13155	COG2201	protein-glutamate methylesterase activity
RY45_RS13165	COG0840	transmembrane signaling receptor activity
RY45_RS13170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RY45_RS13190	COG0659	secondary active sulfate transmembrane transporter activity
RY45_RS13220	COG0672	)-iron permease
RY45_RS13240	COG2814	Major facilitator Superfamily
RY45_RS13250	COG1136	(ABC) transporter
RY45_RS13255	COG0577	efflux transmembrane transporter activity
RY45_RS13290	COG1139	Iron-sulfur cluster binding protein
RY45_RS13295	COG0247	lactate metabolic process
RY45_RS13300	COG1620	l-lactate permease
RY45_RS13305	COG0583	DNA-binding transcription factor activity
RY45_RS13315	COG0346	lactoylglutathione lyase activity
RY45_RS13320	COG0596	Alpha beta hydrolase
RY45_RS13345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RY45_RS13350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RY45_RS13350	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RY45_RS13355	COG0527	aspartate kinase activity
RY45_RS13365	COG1368	sulfuric ester hydrolase activity
RY45_RS13370	COG1619	proteins homologs of microcin C7 resistance protein MccF
RY45_RS13375	COG4667	esterase of the alpha-beta hydrolase superfamily
RY45_RS13395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RY45_RS13395	COG1648	precorrin-2 dehydrogenase activity
RY45_RS13405	COG0393	Putative heavy-metal-binding
RY45_RS13425	COG1252	NADH dehydrogenase
RY45_RS13430	COG3150	esterase
RY45_RS13435	COG2233	PERMEase
RY45_RS13450	COG2354	Protein conserved in bacteria
RY45_RS13460	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RY45_RS13465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RY45_RS13500	COG0537	adenosine 5'-monophosphoramidase activity
RY45_RS13515	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RY45_RS13530	COG1301	dicarboxylic acid transport
RY45_RS13540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RY45_RS13545	COG0861	Integral membrane protein TerC family
RY45_RS13560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RY45_RS13565	COG0601	transmembrane transport
RY45_RS13575	COG2095	MarC family integral membrane protein
RY45_RS13585	COG1454	alcohol dehydrogenase
RY45_RS13585	COG1012	belongs to the aldehyde dehydrogenase family
RY45_RS13590	COG2199	diguanylate cyclase activity
RY45_RS13590	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
RY45_RS13595	COG3275	phosphorelay sensor kinase activity
RY45_RS13600	COG3279	Response regulator of the LytR AlgR family
RY45_RS13605	COG1966	Carbon starvation protein
RY45_RS13615	COG1566	PFAM secretion protein HlyD family protein
RY45_RS13620	COG1061	Type III restriction enzyme res subunit
RY45_RS13625	COG2027	D-alanyl-D-alanine carboxypeptidase
RY45_RS13630	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RY45_RS13640	COG0436	Aminotransferase
RY45_RS13645	COG1288	antiporter activity
RY45_RS13650	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RY45_RS13665	COG0697	spore germination
RY45_RS13670	COG4657	Part of a membrane complex involved in electron transport
RY45_RS13675	COG2878	Part of a membrane complex involved in electron transport
RY45_RS13685	COG4658	electron transport chain
RY45_RS13690	COG4659	FMN binding
RY45_RS13695	COG4660	Part of a membrane complex involved in electron transport
RY45_RS13700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RY45_RS13705	COG0346	lactoylglutathione lyase activity
RY45_RS13720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RY45_RS13725	COG2056	Na+-H+ antiporter family
RY45_RS13735	COG2050	protein possibly involved in aromatic compounds catabolism
RY45_RS13745	COG0247	lactate metabolic process
RY45_RS13745	COG0277	FAD linked oxidase domain protein
RY45_RS13755	COG1253	flavin adenine dinucleotide binding
RY45_RS13760	COG1902	pentaerythritol trinitrate reductase activity
RY45_RS13765	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RY45_RS13770	COG0647	UMP catabolic process
RY45_RS13775	COG4651	solute:proton antiporter activity
RY45_RS13775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RY45_RS13785	COG0367	asparagine synthase
RY45_RS13795	COG0625	glutathione transferase activity
RY45_RS13800	COG0625	glutathione transferase activity
RY45_RS13810	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
RY45_RS13825	COG0564	pseudouridine synthase activity
RY45_RS13830	COG5001	Diguanylate cyclase
RY45_RS13835	COG0840	transmembrane signaling receptor activity
RY45_RS13845	COG0392	lysyltransferase activity
RY45_RS13845	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
RY45_RS13850	COG2194	sulfuric ester hydrolase activity
RY45_RS13865	COG1317	bacterial-type flagellum organization
RY45_RS14025	COG4790	Type iii secretion
RY45_RS14030	COG4794	Type iii secretion
RY45_RS14035	COG4791	protein targeting
RY45_RS14040	COG4792	protein secretion
RY45_RS14055	COG0670	Belongs to the BI1 family
RY45_RS14060	COG1289	transmembrane transporter activity
RY45_RS14065	COG2920	part of a sulfur-relay system
RY45_RS14070	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
RY45_RS14075	COG0285	dihydrofolate synthase activity
RY45_RS14080	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RY45_RS14085	COG0101	tRNA pseudouridine synthase activity
RY45_RS14095	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RY45_RS14100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RY45_RS14105	COG0671	phosphoesterase, PA-phosphatase related
RY45_RS14110	COG1464	Belongs to the NlpA lipoprotein family
RY45_RS14155	COG0574	Belongs to the PEP-utilizing enzyme family
RY45_RS14155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RY45_RS14160	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RY45_RS14220	COG1242	4 iron, 4 sulfur cluster binding
RY45_RS14230	COG0070	glutamate synthase
RY45_RS14230	COG0069	glutamate synthase activity
RY45_RS14230	COG0067	glutamate synthase
RY45_RS14235	COG0493	'glutamate synthase
RY45_RS14240	COG1126	abc transporter atp-binding protein
RY45_RS14245	COG0765	amino acid transport
RY45_RS14250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RY45_RS14265	COG0789	Transcriptional regulator
RY45_RS14280	COG4104	PAAR repeat-containing protein
RY45_RS14290	COG0513	Belongs to the DEAD box helicase family
RY45_RS14295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RY45_RS14330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RY45_RS14335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RY45_RS14340	COG0505	Belongs to the CarA family
RY45_RS14345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RY45_RS14355	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RY45_RS14360	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RY45_RS14365	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RY45_RS14370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RY45_RS14375	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RY45_RS14380	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RY45_RS14390	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
RY45_RS14400	COG2205	protein histidine kinase activity
RY45_RS14400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RY45_RS14415	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RY45_RS14440	COG0023	Translation Initiation Factor
RY45_RS14445	COG2119	membrane
RY45_RS14475	COG2203	Gaf domain
RY45_RS14475	COG2199	diguanylate cyclase activity
RY45_RS14500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RY45_RS14510	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RY45_RS14515	COG3301	Polysulphide reductase, NrfD
RY45_RS14520	COG0437	4 iron, 4 sulfur cluster binding
RY45_RS14525	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
RY45_RS14580	COG0322	excinuclease ABC activity
RY45_RS14585	COG2197	response regulator
RY45_RS14590	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RY45_RS14595	COG2835	tetraacyldisaccharide 4'-kinase activity
RY45_RS14600	COG1663	tetraacyldisaccharide 4'-kinase activity
RY45_RS14610	COG2333	competence protein COMEC
RY45_RS14610	COG0658	competence protein
RY45_RS14625	COG0433	COG0433 Predicted ATPase
RY45_RS14650	COG2267	carboxylic ester hydrolase activity
RY45_RS14655	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RY45_RS14670	COG0314	molybdopterin synthase activity
RY45_RS14675	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RY45_RS14680	COG0315	cyclic pyranopterin monophosphate synthase activity
RY45_RS14685	COG0521	Mo-molybdopterin cofactor biosynthetic process
RY45_RS14690	COG3005	denitrification pathway
RY45_RS14700	COG0348	domain, Protein
RY45_RS14705	COG0437	4 iron, 4 sulfur cluster binding
RY45_RS14710	COG0243	molybdopterin cofactor binding
RY45_RS14720	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
RY45_RS14720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RY45_RS14725	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RY45_RS14730	COG3850	Histidine kinase
RY45_RS14735	COG2197	response regulator
RY45_RS14765	COG0121	glutamine amidotransferase
RY45_RS14770	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RY45_RS14775	COG1960	acyl-CoA dehydrogenase activity
RY45_RS14780	COG0784	Response regulator, receiver
RY45_RS14780	COG3437	response regulator, receiver
RY45_RS14785	COG2239	Acts as a magnesium transporter
RY45_RS14795	COG1256	bacterial-type flagellum assembly
RY45_RS14800	COG1705	Flagellar rod assembly protein muramidase FlgJ
RY45_RS14800	COG3951	Flagellar rod assembly protein muramidase FlgJ
RY45_RS14805	COG1706	bacterial-type flagellum-dependent cell motility
RY45_RS14810	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
RY45_RS14820	COG4787	bacterial-type flagellum-dependent cell motility
RY45_RS14825	COG1749	Flagellar hook protein flgE
RY45_RS14840	COG1815	bacterial-type flagellum-dependent cell motility
RY45_RS14845	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RY45_RS14850	COG0835	chemotaxis
RY45_RS14850	COG0784	Response regulator, receiver
RY45_RS14855	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
RY45_RS14870	COG0622	Phosphoesterase
RY45_RS14900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RY45_RS14905	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RY45_RS14910	COG1882	Formate acetyltransferase
RY45_RS14915	COG1349	DNA-binding transcription factor activity
RY45_RS14925	COG4166	transmembrane transport
RY45_RS14950	COG1278	Cold shock
RY45_RS14990	COG3132	Protein of unknown function, DUF480
RY45_RS15000	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
RY45_RS15010	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RY45_RS15015	COG1091	dTDP-4-dehydrorhamnose reductase activity
RY45_RS15030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RY45_RS15040	COG0438	transferase activity, transferring glycosyl groups
RY45_RS15055	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RY45_RS15070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RY45_RS15075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RY45_RS15080	COG1309	transcriptional regulator
RY45_RS15100	COG1946	Acyl-CoA thioesterase
RY45_RS15110	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RY45_RS15120	COG0009	L-threonylcarbamoyladenylate synthase
RY45_RS15130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RY45_RS15135	COG0512	Glutamine amidotransferase of anthranilate synthase
RY45_RS15135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RY45_RS15140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RY45_RS15145	COG0134	indole-3-glycerol-phosphate synthase activity
RY45_RS15145	COG0135	phosphoribosylanthranilate isomerase activity
RY45_RS15150	COG0133	tryptophan synthase activity
RY45_RS15155	COG0159	tryptophan synthase activity
RY45_RS15165	COG1988	membrane-bound metal-dependent
RY45_RS15185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RY45_RS15200	COG3152	Membrane
RY45_RS15210	COG2814	Major facilitator Superfamily
RY45_RS15215	COG0109	protoheme IX farnesyltransferase activity
RY45_RS15220	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RY45_RS15225	COG1845	cytochrome c oxidase, subunit III
RY45_RS15230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RY45_RS15235	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RY45_RS15280	COG2211	Major facilitator Superfamily
RY45_RS15295	COG0708	Exodeoxyribonuclease III
RY45_RS15315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RY45_RS15320	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RY45_RS15340	COG0095	Lipoate-protein ligase
RY45_RS15370	COG0640	Transcriptional regulator
RY45_RS15385	COG1285	pathogenesis
RY45_RS15390	COG0484	heat shock protein binding
RY45_RS15395	COG0443	Heat shock 70 kDa protein
RY45_RS15400	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RY45_RS15405	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RY45_RS15410	COG0497	DNA recombination
RY45_RS15415	COG1227	inorganic diphosphatase activity
RY45_RS15425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RY45_RS15430	COG0577	efflux transmembrane transporter activity
RY45_RS15430	COG1136	(ABC) transporter
RY45_RS15440	COG2375	cellular response to nickel ion
RY45_RS15450	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RY45_RS15470	COG3152	Membrane
RY45_RS15485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RY45_RS15490	COG1396	sequence-specific DNA binding
RY45_RS15490	COG1917	Cupin 2, conserved barrel domain protein
RY45_RS15505	COG0531	amino acid
RY45_RS15515	COG0531	amino acid
RY45_RS15525	COG1283	sodium-dependent phosphate transmembrane transporter activity
RY45_RS15535	COG3384	dioxygenase
RY45_RS15540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RY45_RS15540	COG2205	protein histidine kinase activity
RY45_RS15555	COG0813	purine-nucleoside phosphorylase activity
RY45_RS15580	COG0488	(ABC) transporter
RY45_RS15590	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RY45_RS15595	COG0083	homoserine kinase activity
RY45_RS15605	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
RY45_RS15610	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
RY45_RS15625	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RY45_RS15635	COG0745	RESPONSE REGULATOR receiver
RY45_RS15650	COG4988	ABC transporter
RY45_RS15655	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RY45_RS15675	COG1720	tRNA m6t6A37 methyltransferase activity
RY45_RS15690	COG0542	response to heat
RY45_RS15695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RY45_RS15700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RY45_RS15710	COG2190	(PTS) system
RY45_RS15725	COG3038	cytochrome b561
RY45_RS15740	COG0419	ATPase involved in DNA repair
RY45_RS15745	COG0420	3'-5' exonuclease activity
RY45_RS15755	COG2974	May be involved in recombination
RY45_RS15765	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RY45_RS15765	COG4651	solute:proton antiporter activity
RY45_RS15780	COG0469	pyruvate kinase activity
RY45_RS15785	COG1196	nuclear chromosome segregation
RY45_RS15785	COG3264	Mechanosensitive ion channel
RY45_RS15795	COG2706	6-phosphogluconolactonase activity
RY45_RS15815	COG0281	malic enzyme
RY45_RS15830	COG0437	4 iron, 4 sulfur cluster binding
RY45_RS15835	COG3383	formate dehydrogenase (NAD+) activity
RY45_RS15835	COG3383	formate dehydrogenase (NAD+) activity
RY45_RS15865	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RY45_RS15870	COG1910	domain protein
RY45_RS15875	COG3852	Histidine kinase
RY45_RS15880	COG2204	response regulator
RY45_RS15890	COG4662	Binding-protein-dependent transport system inner membrane component
RY45_RS15900	COG0746	molybdenum cofactor guanylyltransferase activity
RY45_RS15905	COG0303	'Molybdopterin
RY45_RS15910	COG1289	transmembrane transporter activity
RY45_RS15915	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
RY45_RS15945	COG3220	belongs to the UPF0276 family
RY45_RS15975	COG2205	protein histidine kinase activity
RY45_RS15975	COG0784	Response regulator, receiver
RY45_RS15980	COG4166	transmembrane transport
RY45_RS15985	COG0601	transmembrane transport
RY45_RS15990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RY45_RS15995	COG0444	Belongs to the ABC transporter superfamily
RY45_RS16000	COG4608	Belongs to the ABC transporter superfamily
RY45_RS16010	COG2971	BadF BadG BcrA BcrD
RY45_RS16020	COG0840	transmembrane signaling receptor activity
RY45_RS16035	COG3724	N-succinylarginine dihydrolase activity
RY45_RS16040	COG0616	signal peptide processing
RY45_RS16045	COG1028	Short-chain dehydrogenase reductase Sdr
RY45_RS16050	COG0583	DNA-binding transcription factor activity
RY45_RS16060	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RY45_RS16070	COG0583	DNA-binding transcription factor activity
RY45_RS16075	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RY45_RS16080	COG1881	PFAM PEBP family protein
RY45_RS16090	COG3408	Glycogen debranching enzyme
RY45_RS16090	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
RY45_RS16095	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RY45_RS16100	COG0739	heme binding
RY45_RS16105	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RY45_RS16125	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RY45_RS16135	COG3091	SprT-like family
RY45_RS16145	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RY45_RS16150	COG0189	ligase activity
RY45_RS16160	COG1678	Uncharacterized ACR, COG1678
RY45_RS16165	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RY45_RS16170	COG3104	oligopeptide transport
RY45_RS16195	COG0714	Associated with various cellular activities
RY45_RS16210	COG1115	amino acid carrier protein
RY45_RS16215	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RY45_RS16230	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RY45_RS16240	COG1301	dicarboxylic acid transport
RY45_RS16245	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RY45_RS16250	COG2912	Transglutaminase-like superfamily
RY45_RS16260	COG2890	protein-(glutamine-N5) methyltransferase activity
RY45_RS16265	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RY45_RS16270	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RY45_RS16275	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
RY45_RS16290	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RY45_RS16295	COG0737	Belongs to the 5'-nucleotidase family
RY45_RS16300	COG0193	aminoacyl-tRNA hydrolase activity
RY45_RS16305	COG0012	GTP binding
RY45_RS16350	COG0471	metal ion transport
RY45_RS16350	COG0490	domain, Protein
RY45_RS16360	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
RY45_RS16370	COG3097	Belongs to the UPF0267 family
RY45_RS16380	COG0366	Alpha amylase catalytic
RY45_RS16390	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RY45_RS16390	COG1013	pyruvate-flavodoxin oxidoreductase activity
RY45_RS16390	COG0674	pyruvate-flavodoxin oxidoreductase activity
RY45_RS16390	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RY45_RS16400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RY45_RS16415	COG1012	belongs to the aldehyde dehydrogenase family
RY45_RS16425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RY45_RS16440	COG0180	Tryptophanyl-tRNA synthetase
RY45_RS16450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RY45_RS16455	COG0338	D12 class N6 adenine-specific DNA methyltransferase
RY45_RS16465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RY45_RS16470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RY45_RS16500	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RY45_RS16505	COG0583	DNA-binding transcription factor activity
RY45_RS16525	COG0583	DNA-binding transcription factor activity
RY45_RS16540	COG0739	heme binding
RY45_RS16550	COG1511	domain protein
RY45_RS16550	COG3264	Mechanosensitive ion channel
RY45_RS16555	COG0584	glycerophosphoryl diester phosphodiesterase
RY45_RS16565	COG1053	succinate dehydrogenase
RY45_RS16570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RY45_RS16575	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
RY45_RS16600	COG3214	Protein conserved in bacteria
RY45_RS16640	COG0642	Histidine kinase
RY45_RS16650	COG0516	GMP reductase activity
RY45_RS16660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RY45_RS16665	COG3647	Membrane
RY45_RS16675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RY45_RS16685	COG3706	GGDEF domain
RY45_RS16695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RY45_RS16710	COG3706	GGDEF domain
RY45_RS16720	COG1335	isochorismatase
RY45_RS16725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RY45_RS16730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RY45_RS16735	COG1702	phosphate starvation-inducible protein PhoH
RY45_RS16740	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RY45_RS16745	COG4535	Mg2 and Co2 transporter CorC
RY45_RS16750	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RY45_RS16755	COG2888	peptidyl-tyrosine sulfation
RY45_RS16760	COG0495	leucyl-tRNA aminoacylation
RY45_RS16780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RY45_RS16785	COG0799	negative regulation of ribosome biogenesis
RY45_RS16790	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RY45_RS16795	COG0768	penicillin binding
RY45_RS16800	COG0772	Belongs to the SEDS family
RY45_RS16805	COG2951	lytic endotransglycosylase activity
RY45_RS16810	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RY45_RS16815	COG1686	Belongs to the peptidase S11 family
RY45_RS16820	COG2921	Belongs to the UPF0250 family
RY45_RS16825	COG0321	lipoyl(octanoyl) transferase activity
RY45_RS16830	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RY45_RS16865	COG3545	Serine hydrolase
RY45_RS16870	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
RY45_RS16885	COG0789	Transcriptional regulator
RY45_RS16895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RY45_RS16900	COG1970	mechanosensitive ion channel activity
RY45_RS16905	COG4974	Belongs to the 'phage' integrase family
RY45_RS16915	COG0312	modulator of DNA gyrase
RY45_RS16920	COG0312	modulator of DNA gyrase
RY45_RS16985	COG3275	phosphorelay sensor kinase activity
RY45_RS16990	COG3279	Response regulator of the LytR AlgR family
RY45_RS16995	COG1966	Carbon starvation protein
RY45_RS17005	COG0114	fumarate hydratase activity
RY45_RS17015	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
RY45_RS17025	COG2211	Major facilitator Superfamily
RY45_RS17030	COG1185	polyribonucleotide nucleotidyltransferase activity
RY45_RS17035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RY45_RS17040	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RY45_RS17045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RY45_RS17050	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RY45_RS17055	COG0195	Participates in both transcription termination and antitermination
RY45_RS17060	COG0779	Required for maturation of 30S ribosomal subunits
RY45_RS17075	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RY45_RS17080	COG0149	triose-phosphate isomerase activity
RY45_RS17085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RY45_RS17090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RY45_RS17100	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RY45_RS17105	COG1534	Rna-binding protein
RY45_RS17120	COG1360	Flagellar Motor Protein
RY45_RS17125	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RY45_RS17130	COG1722	exodeoxyribonuclease VII activity
RY45_RS17135	COG0142	geranyltranstransferase activity
RY45_RS17140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RY45_RS17150	COG0601	transmembrane transport
RY45_RS17165	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RY45_RS17170	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RY45_RS17175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RY45_RS17180	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RY45_RS17200	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RY45_RS17200	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RY45_RS17205	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RY45_RS17215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RY45_RS17230	COG3381	protein complex oligomerization
RY45_RS17250	COG3300	MHYT domain
RY45_RS17250	COG5001	Diguanylate cyclase
RY45_RS17260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RY45_RS17265	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RY45_RS17270	COG0511	ligase activity, forming carbon-carbon bonds
RY45_RS17275	COG0439	Biotin carboxylase
RY45_RS17285	COG4145	pantothenate transmembrane transporter activity
RY45_RS17290	COG2190	(PTS) system
RY45_RS17290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RY45_RS17290	COG1263	PTS System
RY45_RS17295	COG0583	DNA-binding transcription factor activity
RY45_RS17300	COG0604	alcohol dehydrogenase
RY45_RS17305	COG2264	protein methyltransferase activity
RY45_RS17320	COG0778	Nitroreductase
RY45_RS17325	COG1902	pentaerythritol trinitrate reductase activity
RY45_RS17325	COG0446	pyridine nucleotide-disulphide oxidoreductase
RY45_RS17330	COG0616	signal peptide processing
RY45_RS17350	COG3139	Protein of unknown function (DUF1315)
RY45_RS17355	COG0252	asparaginase activity
RY45_RS17360	COG0786	glutamate:sodium symporter activity
RY45_RS17370	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RY45_RS17375	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RY45_RS17380	COG0384	phenazine biosynthesis protein PhzF
RY45_RS17385	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RY45_RS17390	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RY45_RS17395	COG0175	sulfate reduction
RY45_RS17400	COG2113	Glycine betaine
RY45_RS17405	COG4176	ABC-type proline glycine betaine transport system permease component
RY45_RS17410	COG4175	Glycine betaine
RY45_RS17420	COG3610	response to peptide
RY45_RS17425	COG2966	Psort location CytoplasmicMembrane, score
RY45_RS17435	COG0521	Mo-molybdopterin cofactor biosynthetic process
RY45_RS17450	COG1028	Short-chain dehydrogenase reductase Sdr
RY45_RS17460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RY45_RS17510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RY45_RS17515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RY45_RS17550	COG1858	cytochrome C peroxidase
RY45_RS17560	COG2313	pseudouridylate synthase activity
RY45_RS17565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RY45_RS17570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RY45_RS17570	COG2146	nitrite reductase [NAD(P)H] activity
RY45_RS17575	COG2146	nitrite reductase [NAD(P)H] activity
RY45_RS17575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RY45_RS17580	COG1116	anion transmembrane transporter activity
RY45_RS17585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RY45_RS17590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RY45_RS17590	COG1116	anion transmembrane transporter activity
RY45_RS17605	COG0243	molybdopterin cofactor binding
RY45_RS17630	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RY45_RS17645	COG1073	alpha beta
RY45_RS17650	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
RY45_RS17655	COG2195	Cleaves the N-terminal amino acid of tripeptides
RY45_RS17660	COG4608	Belongs to the ABC transporter superfamily
RY45_RS17665	COG0444	Belongs to the ABC transporter superfamily
RY45_RS17675	COG4239	(ABC) transporter, permease
RY45_RS17680	COG4174	ABC transporter (Permease)
RY45_RS17695	COG0811	peptide transport
RY45_RS17700	COG0811	peptide transport
RY45_RS17705	COG0848	biopolymer transport protein
RY45_RS17760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RY45_RS17765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RY45_RS17770	COG0840	transmembrane signaling receptor activity
RY45_RS17780	COG1278	Cold shock
RY45_RS17810	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
RY45_RS17815	COG1162	GTPase activity
RY45_RS17820	COG0688	phosphatidylethanolamine metabolic process
RY45_RS17825	COG4628	conserved protein (DUF2132)
RY45_RS17840	COG3059	membrane
RY45_RS17845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RY45_RS17850	COG2207	Transcriptional regulator
RY45_RS17860	COG3300	MHYT domain
RY45_RS17860	COG5001	Diguanylate cyclase
RY45_RS17865	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
RY45_RS17890	COG1132	(ABC) transporter
RY45_RS17900	COG1404	Belongs to the peptidase S8 family
RY45_RS17905	COG2897	thiosulfate sulfurtransferase activity
RY45_RS17910	COG2066	Belongs to the glutaminase family
RY45_RS17915	COG3171	Protein conserved in bacteria
RY45_RS17920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RY45_RS17925	COG2234	aminopeptidase activity
RY45_RS17925	COG4935	Belongs to the peptidase S8 family
RY45_RS17930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RY45_RS17935	COG2200	EAL domain
RY45_RS17940	COG1090	epimerase
RY45_RS17945	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RY45_RS17950	COG4181	ATPase activity
RY45_RS17955	COG2755	lipolytic protein G-D-S-L family
RY45_RS17960	COG0784	Response regulator, receiver
RY45_RS17960	COG0835	chemotaxis
RY45_RS17970	COG0569	domain protein
RY45_RS17970	COG2985	domain, Protein
RY45_RS17975	COG1272	protein, Hemolysin III
RY45_RS17980	COG0076	glutamate decarboxylase activity
RY45_RS17985	COG2917	probably involved in intracellular septation
RY45_RS17990	COG2350	Protein conserved in bacteria
RY45_RS18000	COG1555	photosystem II stabilization
RY45_RS18005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RY45_RS18010	COG3104	oligopeptide transport
RY45_RS18015	COG0745	RESPONSE REGULATOR receiver
RY45_RS18045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RY45_RS18060	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
RY45_RS18065	COG1280	lysine exporter protein (LysE YggA)
RY45_RS18090	COG0316	Belongs to the HesB IscA family
RY45_RS18100	COG0038	chloride channel
RY45_RS18105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RY45_RS18120	COG0671	phosphoesterase, PA-phosphatase related
RY45_RS18130	COG3437	response regulator, receiver
RY45_RS18130	COG0784	Response regulator, receiver
RY45_RS18140	COG2076	Multidrug Resistance protein
RY45_RS18150	COG0346	lactoylglutathione lyase activity
RY45_RS18155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RY45_RS18160	COG1643	Atp-dependent helicase
RY45_RS18170	COG1489	DNA binding
RY45_RS18175	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RY45_RS18180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RY45_RS18195	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RY45_RS18200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RY45_RS18230	COG1924	4 iron, 4 sulfur cluster binding
RY45_RS18235	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
RY45_RS18240	COG0842	Transport permease protein
RY45_RS18245	COG1131	(ABC) transporter
RY45_RS18260	COG0163	prenyltransferase activity
RY45_RS18265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RY45_RS18270	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RY45_RS18285	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
RY45_RS18300	COG1136	(ABC) transporter
RY45_RS18320	COG0840	transmembrane signaling receptor activity
RY45_RS18330	COG0529	Catalyzes the synthesis of activated sulfate
RY45_RS18335	COG0471	metal ion transport
RY45_RS18335	COG3273	potassium ion transport
RY45_RS18340	COG2895	sulfate adenylyltransferase (ATP) activity
RY45_RS18345	COG0175	sulfate reduction
RY45_RS18350	COG1648	precorrin-2 dehydrogenase activity
RY45_RS18350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RY45_RS18355	COG0330	HflC and HflK could
RY45_RS18360	COG1585	Membrane protein implicated in regulation of membrane protease activity
RY45_RS18365	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RY45_RS18365	COG0517	IMP dehydrogenase activity
RY45_RS18370	COG0488	(ABC) transporter
RY45_RS18380	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RY45_RS18405	COG0789	Transcriptional regulator
RY45_RS18415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RY45_RS18425	COG0668	transmembrane transport
RY45_RS18435	COG2731	YhcH YjgK YiaL family protein
RY45_RS18450	COG1794	racemase activity, acting on amino acids and derivatives
RY45_RS18465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RY45_RS18490	COG0733	neurotransmitter:sodium symporter activity
RY45_RS18500	COG0733	neurotransmitter:sodium symporter activity
RY45_RS18515	COG0561	phosphatase activity
RY45_RS18545	COG1846	Transcriptional regulator
RY45_RS18550	COG1764	response to oxidative stress
RY45_RS18555	COG2130	NADP-dependent
RY45_RS18560	COG1051	belongs to the nudix hydrolase family
RY45_RS18580	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RY45_RS18585	COG1640	4-alpha-glucanotransferase
RY45_RS18590	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RY45_RS18595	COG0676	glucose-6-phosphate 1-epimerase activity
RY45_RS18600	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RY45_RS18605	COG0840	transmembrane signaling receptor activity
RY45_RS18640	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
RY45_RS18645	COG2885	chlorophyll binding
RY45_RS18650	COG0823	Involved in the tonB-independent uptake of proteins
RY45_RS18665	COG0811	peptide transport
RY45_RS18670	COG0824	Thioesterase
RY45_RS18675	COG3790	cyd operon protein YbgE
RY45_RS18685	COG1294	oxidase, subunit
RY45_RS18690	COG1271	oxidase subunit
RY45_RS18695	COG2255	four-way junction helicase activity
RY45_RS18700	COG0632	four-way junction helicase activity
RY45_RS18705	COG0840	transmembrane signaling receptor activity
RY45_RS18710	COG0442	prolyl-tRNA aminoacylation
RY45_RS18715	COG4221	oxidoreductase activity
RY45_RS18730	COG1024	Enoyl-CoA hydratase
RY45_RS18740	COG0110	maltose O-acetyltransferase activity
RY45_RS18750	COG4166	transmembrane transport
RY45_RS18765	COG1872	DUF167
RY45_RS18770	COG0762	integral membrane protein
RY45_RS18775	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RY45_RS18780	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RY45_RS18795	COG3022	response to hydroperoxide
RY45_RS18800	COG0513	Belongs to the DEAD box helicase family
RY45_RS18805	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
RY45_RS18835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RY45_RS18845	COG0776	regulation of translation
RY45_RS18850	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
RY45_RS18875	COG0560	Phosphoserine phosphatase
RY45_RS18885	COG5002	protein histidine kinase activity
RY45_RS18885	COG3447	MASE1 domain protein
RY45_RS18885	COG5001	Diguanylate cyclase
RY45_RS18890	COG0813	purine-nucleoside phosphorylase activity
RY45_RS18895	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
RY45_RS18900	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
RY45_RS18905	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
RY45_RS18915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RY45_RS18920	COG0084	hydrolase, TatD family'
RY45_RS18925	COG2165	general secretion pathway protein
RY45_RS18930	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RY45_RS18935	COG0004	ammonium transporteR
RY45_RS18940	COG4974	Belongs to the 'phage' integrase family
RY45_RS18955	COG1396	sequence-specific DNA binding
RY45_RS19020	COG4695	Portal protein
RY45_RS19160	COG0795	lipopolysaccharide-transporting ATPase activity
RY45_RS19165	COG0795	lipopolysaccharide-transporting ATPase activity
RY45_RS19170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RY45_RS19180	COG0525	valine-tRNA ligase activity
RY45_RS19185	COG1253	flavin adenine dinucleotide binding
RY45_RS19190	COG0586	Pfam SNARE associated Golgi protein
RY45_RS19195	COG1686	Belongs to the peptidase S11 family
RY45_RS19230	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
RY45_RS19235	COG0527	aspartate kinase activity
RY45_RS19240	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RY45_RS19250	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RY45_RS19255	COG1546	Belongs to the CinA family
RY45_RS19260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RY45_RS19285	COG3068	Protein conserved in bacteria
RY45_RS19295	COG0739	heme binding
RY45_RS19315	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
RY45_RS19320	COG1121	(ABC) transporter
RY45_RS19325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RY45_RS19330	COG0583	DNA-binding transcription factor activity
RY45_RS19335	COG0697	spore germination
RY45_RS19340	COG1573	uracil-dna glycosylase
RY45_RS19345	COG2962	Rard protein
RY45_RS19355	COG2827	Endonuclease containing a URI domain
RY45_RS19370	COG1842	Phage shock protein A
RY45_RS19375	COG0204	Acyl-transferase
RY45_RS19395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RY45_RS19435	COG0583	DNA-binding transcription factor activity
RY45_RS19450	COG1289	transmembrane transporter activity
RY45_RS19455	COG1566	PFAM secretion protein HlyD family protein
RY45_RS19470	COG1051	belongs to the nudix hydrolase family
RY45_RS19475	COG3150	esterase
RY45_RS19485	COG3151	Protein conserved in bacteria
RY45_RS19490	COG0494	nUDIX hydrolase
RY45_RS19495	COG1538	Outer membrane efflux protein
RY45_RS19500	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RY45_RS19500	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RY45_RS19505	COG1560	Kdo2-lipid A biosynthetic process
RY45_RS19520	COG1392	Phosphate transport regulator
RY45_RS19525	COG0306	phosphate transporter
RY45_RS19530	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RY45_RS19560	COG0583	DNA-binding transcription factor activity
RY45_RS19565	COG1380	Effector of murein hydrolase LrgA
RY45_RS19570	COG1346	cytolysis
RY45_RS19585	COG0617	tRNA 3'-terminal CCA addition
RY45_RS19590	COG3409	Peptidoglycan-binding domain 1 protein
RY45_RS19590	COG3267	Type II secretory pathway component ExeA
RY45_RS19600	COG1194	a g-specific adenine glycosylase
RY45_RS19605	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
RY45_RS19615	COG3111	PFAM Bacterial OB fold (BOF) protein
RY45_RS19620	COG3240	lipase activity
RY45_RS19630	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RY45_RS19630	COG2885	chlorophyll binding
RY45_RS19635	COG3009	Protein conserved in bacteria
RY45_RS19640	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RY45_RS19640	COG3008	intermembrane lipid transfer
RY45_RS19645	COG2995	paraquat-inducible protein a
RY45_RS19655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RY45_RS19665	COG4251	negative regulation of phosphorylation
RY45_RS19665	COG3706	GGDEF domain
RY45_RS19665	COG2203	Gaf domain
RY45_RS19665	COG5001	Diguanylate cyclase
RY45_RS19670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RY45_RS19675	COG2813	Specifically methylates the guanine in position
RY45_RS19680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RY45_RS19685	COG0297	glycogen (starch) synthase activity
RY45_RS19725	COG1757	Na H antiporter
RY45_RS19730	COG0583	DNA-binding transcription factor activity
RY45_RS19735	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RY45_RS19740	COG3842	ATPase activity
RY45_RS19745	COG1176	ABC-type spermidine putrescine transport system, permease component I
RY45_RS19750	COG1177	transmembrane transport
RY45_RS19755	COG1012	belongs to the aldehyde dehydrogenase family
RY45_RS19765	COG5006	permease, DMT superfamily
RY45_RS19770	COG1522	sequence-specific DNA binding
RY45_RS19775	COG0110	maltose O-acetyltransferase activity
RY45_RS19780	COG0366	Alpha amylase catalytic
RY45_RS19785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RY45_RS19785	COG1263	PTS System
RY45_RS19805	COG0252	asparaginase activity
RY45_RS19820	COG1803	Methylglyoxal synthase
RY45_RS19845	COG1444	tRNA N-acetyltransferase activity
RY45_RS19850	COG1028	Short-chain dehydrogenase reductase Sdr
RY45_RS19855	COG0784	Response regulator, receiver
RY45_RS19855	COG0835	chemotaxis
RY45_RS19860	COG3314	Sporulation integral membrane protein YlbJ
RY45_RS19905	COG3501	Rhs element vgr protein
RY45_RS19935	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RY45_RS19940	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RY45_RS19955	COG0477	Major facilitator Superfamily
RY45_RS19960	COG0523	cobalamin synthesis protein
RY45_RS19965	COG0277	FAD linked oxidase domain protein
RY45_RS19970	COG1280	lysine exporter protein (LysE YggA)
RY45_RS19980	COG2200	EAL domain
RY45_RS19985	COG1049	propionate catabolic process, 2-methylcitrate cycle
RY45_RS19990	COG1752	Esterase of the alpha-beta hydrolase superfamily
RY45_RS20010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RY45_RS20015	COG0508	dehydrogenase complex catalyzes the overall conversion of
RY45_RS20020	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RY45_RS20025	COG2186	Transcriptional regulator
RY45_RS20050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RY45_RS20055	COG1459	type II secretion system
RY45_RS20070	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
RY45_RS20075	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
RY45_RS20080	COG0494	nUDIX hydrolase
RY45_RS20090	COG0653	protein targeting
RY45_RS20100	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
RY45_RS20105	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RY45_RS20110	COG0849	cell division
RY45_RS20115	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RY45_RS20120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RY45_RS20125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RY45_RS20130	COG0772	Belongs to the SEDS family
RY45_RS20135	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RY45_RS20140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RY45_RS20145	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RY45_RS20155	COG0768	penicillin binding
RY45_RS20160	COG3116	cell division
RY45_RS20165	COG0275	rRNA processing
RY45_RS20170	COG2001	Belongs to the MraZ family
RY45_RS20180	COG1388	LysM domain
RY45_RS20180	COG0741	lytic transglycosylase activity
RY45_RS20185	COG1360	Flagellar Motor Protein
RY45_RS20190	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RY45_RS20195	COG1191	sigma factor activity
RY45_RS20220	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RY45_RS20225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RY45_RS20245	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RY45_RS20250	COG4786	Flagellar basal body rod
RY45_RS20250	COG1256	bacterial-type flagellum assembly
RY45_RS20260	COG1706	bacterial-type flagellum-dependent cell motility
RY45_RS20265	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
RY45_RS20270	COG4786	Flagellar basal body rod
RY45_RS20280	COG1749	Flagellar hook protein flgE
RY45_RS20295	COG1815	bacterial-type flagellum-dependent cell motility
RY45_RS20330	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RY45_RS20340	COG1677	Flagellar hook-basal body complex protein FliE
RY45_RS20385	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RY45_RS20390	COG3107	peptidoglycan biosynthetic process
RY45_RS20395	COG0792	nuclease activity
RY45_RS20400	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RY45_RS20405	COG2823	Periplasmic or secreted lipoprotein
RY45_RS20410	COG2969	positive regulation of protein catabolic process
RY45_RS20415	COG0625	glutathione transferase activity
RY45_RS20420	COG2857	Cytochrome c1
RY45_RS20425	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RY45_RS20430	COG0723	plastoquinol--plastocyanin reductase activity
RY45_RS20435	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RY45_RS20440	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RY45_RS20445	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RY45_RS20455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RY45_RS20460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RY45_RS20490	COG3964	amidohydrolase
RY45_RS20510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RY45_RS20515	COG1660	Displays ATPase and GTPase activities
RY45_RS20520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RY45_RS20530	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RY45_RS20535	COG1137	ATPase activity
RY45_RS20540	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
RY45_RS20545	COG3117	lipopolysaccharide transmembrane transporter activity
RY45_RS20550	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RY45_RS20555	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RY45_RS20555	COG0517	IMP dehydrogenase activity
RY45_RS20560	COG1127	ABC transporter
RY45_RS20565	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RY45_RS20570	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RY45_RS20575	COG2854	intermembrane phospholipid transfer
RY45_RS20585	COG5007	Belongs to the BolA IbaG family
RY45_RS20590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RY45_RS20595	COG0312	modulator of DNA gyrase
RY45_RS20600	COG3028	Belongs to the UPF0307 family
RY45_RS20610	COG2926	Belongs to the UPF0265 family
RY45_RS20640	COG1396	sequence-specific DNA binding
RY45_RS20645	COG3135	benzoate transporter
RY45_RS20675	COG3047	cAMP biosynthetic process
RY45_RS20685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RY45_RS20690	COG2197	response regulator
RY45_RS20695	COG0629	single-stranded DNA binding
RY45_RS20715	COG1278	Cold shock
RY45_RS20725	COG4771	TonB-dependent receptor
RY45_RS20730	COG3706	GGDEF domain
RY45_RS20775	COG0346	lactoylglutathione lyase activity
RY45_RS20785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RY45_RS20790	COG1074	ATP-dependent DNA helicase activity
RY45_RS20795	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
RY45_RS20800	COG2259	Doxx family
RY45_RS20805	COG1741	Belongs to the pirin family
RY45_RS20815	COG0583	DNA-binding transcription factor activity
RY45_RS20840	COG1176	ABC-type spermidine putrescine transport system, permease component I
RY45_RS20850	COG3842	ATPase activity
RY45_RS20860	COG2203	Gaf domain
RY45_RS20860	COG2199	diguanylate cyclase activity
RY45_RS20880	COG1247	-acetyltransferase
RY45_RS20885	COG0753	catalase activity
RY45_RS20910	COG0494	nUDIX hydrolase
RY45_RS20915	COG0628	permease
RY45_RS20930	COG2957	Belongs to the agmatine deiminase family
RY45_RS20935	COG0583	DNA-binding transcription factor activity
RY45_RS20940	COG3284	Transcriptional regulator
RY45_RS20955	COG1461	Dihydroxyacetone kinase
RY45_RS20960	COG2376	Dihydroxyacetone kinase
RY45_RS20970	COG2252	PERMEase
RY45_RS21005	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RY45_RS21010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RY45_RS21015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RY45_RS21020	COG0049	tRNA binding
RY45_RS21030	COG2168	tRNA wobble position uridine thiolation
RY45_RS21045	COG0251	oxidation-reduction process
RY45_RS21050	COG2964	Protein conserved in bacteria
RY45_RS21055	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RY45_RS21060	COG0085	RNA polymerase activity
RY45_RS21065	COG0222	ribosome binding
RY45_RS21070	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RY45_RS21075	COG0081	regulation of translation
RY45_RS21080	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RY45_RS21085	COG0250	Participates in transcription elongation, termination and antitermination
RY45_RS21100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RY45_RS21125	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RY45_RS21130	COG0569	domain protein
RY45_RS21135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RY45_RS21140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RY45_RS21145	COG3005	denitrification pathway
RY45_RS21150	COG0243	molybdopterin cofactor binding
RY45_RS21180	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RY45_RS21195	COG2204	response regulator
RY45_RS21205	COG2205	protein histidine kinase activity
RY45_RS21225	COG5413	integral membrane protein
RY45_RS21235	COG1522	sequence-specific DNA binding
RY45_RS21240	COG2502	aspartate--ammonia ligase
RY45_RS21245	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RY45_RS21250	COG0542	response to heat
RY45_RS21260	COG0564	pseudouridine synthase activity
RY45_RS21265	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RY45_RS21270	COG0446	pyridine nucleotide-disulphide oxidoreductase
RY45_RS21280	COG3681	Belongs to the UPF0597 family
RY45_RS21290	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
RY45_RS21295	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RY45_RS21300	COG1979	alcohol dehydrogenase
RY45_RS21305	COG2207	Transcriptional regulator
RY45_RS21310	COG3040	lipid binding
RY45_RS21320	COG0688	phosphatidylethanolamine metabolic process
RY45_RS21335	COG0540	Belongs to the ATCase OTCase family
RY45_RS21340	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
RY45_RS21345	COG1438	arginine binding
RY45_RS21350	COG1288	antiporter activity
RY45_RS21355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RY45_RS21400	COG3250	beta-galactosidase activity
RY45_RS21405	COG1609	Transcriptional regulator
RY45_RS21410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RY45_RS21420	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RY45_RS21425	COG2017	converts alpha-aldose to the beta-anomer
RY45_RS21430	COG0667	Aldo Keto reductase
RY45_RS21435	COG1968	undecaprenyl-diphosphatase activity
RY45_RS21440	COG3806	Anti-sigma factor
RY45_RS21445	COG1595	DNA-templated transcription, initiation
RY45_RS21465	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RY45_RS21470	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RY45_RS21475	COG0477	Major facilitator Superfamily
RY45_RS21485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RY45_RS21495	COG2116	formate transmembrane transporter activity
RY45_RS21500	COG1648	precorrin-2 dehydrogenase activity
RY45_RS21500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RY45_RS21505	COG2239	Acts as a magnesium transporter
RY45_RS21515	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RY45_RS21520	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RY45_RS21530	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RY45_RS21540	COG0514	ATP-dependent DNA helicase (RecQ)
RY45_RS21545	COG2050	protein possibly involved in aromatic compounds catabolism
RY45_RS21560	COG2258	MOSC domain
RY45_RS21565	COG1177	transmembrane transport
RY45_RS21570	COG1176	ABC-type spermidine putrescine transport system, permease component I
RY45_RS21575	COG3842	ATPase activity
RY45_RS21595	COG0174	glutamine synthetase
RY45_RS21615	COG3045	CreA protein
RY45_RS21620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RY45_RS21625	COG0443	Heat shock 70 kDa protein
RY45_RS21640	COG0366	Alpha amylase catalytic
RY45_RS21645	COG1086	Polysaccharide biosynthesis protein
RY45_RS21650	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RY45_RS21655	COG4750	Nucleotidyl transferase
RY45_RS21660	COG0519	Catalyzes the synthesis of GMP from XMP
RY45_RS21665	COG3848	Pyruvate phosphate dikinase
RY45_RS21665	COG0574	Belongs to the PEP-utilizing enzyme family
RY45_RS21690	COG1215	transferase activity, transferring glycosyl groups
RY45_RS21705	COG0318	PFAM AMP-dependent synthetase and ligase
RY45_RS21710	COG1028	Short-chain dehydrogenase reductase Sdr
RY45_RS21725	COG1083	cytidylyl-transferase
RY45_RS21735	COG2089	acid synthase
RY45_RS21755	COG4310	Domain of unknown function (DUF2172)
RY45_RS21790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RY45_RS21795	COG0745	RESPONSE REGULATOR receiver
RY45_RS21800	COG2205	protein histidine kinase activity
RY45_RS21810	COG0281	malic enzyme
RY45_RS21815	COG0702	epimerase
RY45_RS21820	COG0254	rRNA binding
RY45_RS21825	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RY45_RS21855	COG0129	dihydroxy-acid dehydratase activity
RY45_RS21865	COG3978	acetolactate synthase activity
RY45_RS21875	COG0606	chelatase, subunit chli
RY45_RS21880	COG0204	Acyl-transferase
RY45_RS21885	COG0204	Acyl-transferase
RY45_RS21890	COG1683	Conserved Protein
RY45_RS21900	COG1335	isochorismatase
RY45_RS21910	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
RY45_RS21915	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RY45_RS21920	COG3639	organic phosphonate transmembrane transporter activity
RY45_RS21925	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RY45_RS21930	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RY45_RS21940	COG3084	Protein conserved in bacteria
RY45_RS21945	COG5001	Diguanylate cyclase
RY45_RS21945	COG2203	Gaf domain
RY45_RS21945	COG4251	negative regulation of phosphorylation
RY45_RS21945	COG3706	GGDEF domain
RY45_RS21950	COG0789	Transcriptional regulator
RY45_RS21960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RY45_RS21965	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RY45_RS21970	COG1561	YicC-like family, N-terminal region
RY45_RS21990	COG3306	glycosyltransferase involved in LPS biosynthesis
RY45_RS22005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RY45_RS22015	COG0156	8-amino-7-oxononanoate synthase activity
RY45_RS22020	COG1063	alcohol dehydrogenase
RY45_RS22025	COG3245	cytochrome
RY45_RS22035	COG0210	DNA helicase
RY45_RS22040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RY45_RS22045	COG2166	iron-sulfur cluster assembly
RY45_RS22050	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RY45_RS22090	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
RY45_RS22095	COG0848	biopolymer transport protein
RY45_RS22100	COG0811	peptide transport
RY45_RS22105	COG0811	peptide transport
RY45_RS22115	COG2771	luxR family
RY45_RS22120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RY45_RS22125	COG1349	DNA-binding transcription factor activity
RY45_RS22130	COG0745	RESPONSE REGULATOR receiver
RY45_RS22135	COG2205	protein histidine kinase activity
RY45_RS22145	COG4452	Inner membrane protein CreD
RY45_RS22150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RY45_RS22155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RY45_RS22160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RY45_RS22165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RY45_RS22170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RY45_RS22175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RY45_RS22180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RY45_RS22190	COG0356	it plays a direct role in the translocation of protons across the membrane
RY45_RS22200	COG1475	DNA binding
RY45_RS22205	COG1192	Involved in chromosome partitioning
RY45_RS22210	COG0357	Ribosomal RNA small subunit methyltransferase G
RY45_RS22215	COG0445	tRNA wobble uridine modification
RY45_RS22220	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RY45_RS22225	COG4774	siderophore transport
RY45_RS22230	COG4615	Cyclic peptide transporter
RY45_RS22235	COG1120	ATPase activity
RY45_RS22250	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RY45_RS22255	COG0706	membrane insertase activity
RY45_RS22260	COG0594	ribonuclease P activity
RY45_RS22265	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RY45_RS22270	COG1126	abc transporter atp-binding protein
RY45_RS22305	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RY45_RS22350	COG0187	DNA topoisomerase II activity
RY45_RS22355	COG0187	DNA topoisomerase II activity
RY45_RS22450	COG3646	Phage regulatory protein