locus-tag	class	description
NRZ33_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NRZ33_RS00010	COG0592	DNA-directed DNA polymerase activity
NRZ33_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NRZ33_RS00030	COG2378	regulation of single-species biofilm formation
NRZ33_RS00040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NRZ33_RS00045	COG0071	Belongs to the small heat shock protein (HSP20) family
NRZ33_RS00050	COG0071	Belongs to the small heat shock protein (HSP20) family
NRZ33_RS00055	COG3977	Valine--pyruvate aminotransferase
NRZ33_RS00070	COG2814	Major facilitator Superfamily
NRZ33_RS00075	COG0745	RESPONSE REGULATOR receiver
NRZ33_RS00080	COG2205	protein histidine kinase activity
NRZ33_RS00100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NRZ33_RS00105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ33_RS00105	COG4191	Histidine kinase
NRZ33_RS00110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRZ33_RS00115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRZ33_RS00120	COG1309	transcriptional regulator
NRZ33_RS00150	COG0469	pyruvate kinase activity
NRZ33_RS00155	COG2271	Major facilitator Superfamily
NRZ33_RS00180	COG0561	phosphatase activity
NRZ33_RS00185	COG2267	carboxylic ester hydrolase activity
NRZ33_RS00195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NRZ33_RS00200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NRZ33_RS00205	COG1758	RNA polymerase activity
NRZ33_RS00215	COG0859	PFAM glycosyl transferase family 9
NRZ33_RS00220	COG3642	lipopolysaccharide core region biosynthetic process
NRZ33_RS00260	COG0589	response to stress
NRZ33_RS00270	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NRZ33_RS00280	COG1528	Iron-storage protein
NRZ33_RS00285	COG2081	HI0933 family
NRZ33_RS00290	COG2223	nitrite transmembrane transporter activity
NRZ33_RS00305	COG3121	Chaperone
NRZ33_RS00310	COG3188	usher protein
NRZ33_RS00320	COG3121	Chaperone
NRZ33_RS00330	COG2197	response regulator
NRZ33_RS00335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ33_RS00335	COG2205	protein histidine kinase activity
NRZ33_RS00350	COG1280	lysine exporter protein (LysE YggA)
NRZ33_RS00365	COG3188	usher protein
NRZ33_RS00395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ33_RS00395	COG2205	protein histidine kinase activity
NRZ33_RS00405	COG3275	phosphorelay sensor kinase activity
NRZ33_RS00410	COG3279	Response regulator of the LytR AlgR family
NRZ33_RS00415	COG2223	nitrite transmembrane transporter activity
NRZ33_RS00420	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NRZ33_RS00425	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NRZ33_RS00440	COG0583	DNA-binding transcription factor activity
NRZ33_RS00450	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NRZ33_RS00485	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NRZ33_RS00490	COG2166	iron-sulfur cluster assembly
NRZ33_RS00495	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NRZ33_RS00500	COG0210	DNA helicase
NRZ33_RS00510	COG3245	cytochrome
NRZ33_RS00515	COG1063	alcohol dehydrogenase
NRZ33_RS00520	COG0156	8-amino-7-oxononanoate synthase activity
NRZ33_RS00530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRZ33_RS00545	COG3306	glycosyltransferase involved in LPS biosynthesis
NRZ33_RS00565	COG4774	siderophore transport
NRZ33_RS00570	COG4607	ABC-type enterochelin transport system periplasmic component
NRZ33_RS00575	COG4604	ABC transporter, ATP-binding protein
NRZ33_RS00580	COG4605	iron ion homeostasis
NRZ33_RS00585	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRZ33_RS00590	COG1132	(ABC) transporter
NRZ33_RS00595	COG2375	cellular response to nickel ion
NRZ33_RS00595	COG1132	(ABC) transporter
NRZ33_RS00615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRZ33_RS00625	COG0076	glutamate decarboxylase activity
NRZ33_RS00630	COG1561	YicC-like family, N-terminal region
NRZ33_RS00635	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NRZ33_RS00640	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NRZ33_RS00655	COG2203	Gaf domain
NRZ33_RS00655	COG4251	negative regulation of phosphorylation
NRZ33_RS00655	COG5001	Diguanylate cyclase
NRZ33_RS00655	COG3706	GGDEF domain
NRZ33_RS00660	COG3084	Protein conserved in bacteria
NRZ33_RS00670	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NRZ33_RS00675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NRZ33_RS00685	COG1335	isochorismatase
NRZ33_RS00695	COG1683	Conserved Protein
NRZ33_RS00700	COG0204	Acyl-transferase
NRZ33_RS00705	COG0204	Acyl-transferase
NRZ33_RS00710	COG0606	chelatase, subunit chli
NRZ33_RS00720	COG3978	acetolactate synthase activity
NRZ33_RS00730	COG0129	dihydroxy-acid dehydratase activity
NRZ33_RS00750	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NRZ33_RS00755	COG0254	rRNA binding
NRZ33_RS00760	COG0702	epimerase
NRZ33_RS00765	COG0281	malic enzyme
NRZ33_RS00775	COG2205	protein histidine kinase activity
NRZ33_RS00780	COG0745	RESPONSE REGULATOR receiver
NRZ33_RS00785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NRZ33_RS00820	COG4310	Domain of unknown function (DUF2172)
NRZ33_RS00840	COG2089	acid synthase
NRZ33_RS00850	COG1083	cytidylyl-transferase
NRZ33_RS00865	COG1028	Short-chain dehydrogenase reductase Sdr
NRZ33_RS00870	COG0318	PFAM AMP-dependent synthetase and ligase
NRZ33_RS00885	COG1215	transferase activity, transferring glycosyl groups
NRZ33_RS00890	COG0562	UDP-galactopyranose mutase
NRZ33_RS00925	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NRZ33_RS00930	COG0367	asparagine synthase
NRZ33_RS00940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NRZ33_RS00945	COG1086	Polysaccharide biosynthesis protein
NRZ33_RS00950	COG0366	Alpha amylase catalytic
NRZ33_RS00965	COG0443	Heat shock 70 kDa protein
NRZ33_RS00970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NRZ33_RS00975	COG3045	CreA protein
NRZ33_RS00995	COG0174	glutamine synthetase
NRZ33_RS01015	COG3842	ATPase activity
NRZ33_RS01020	COG1176	ABC-type spermidine putrescine transport system, permease component I
NRZ33_RS01025	COG1177	transmembrane transport
NRZ33_RS01030	COG2258	MOSC domain
NRZ33_RS01045	COG2050	protein possibly involved in aromatic compounds catabolism
NRZ33_RS01050	COG0514	ATP-dependent DNA helicase (RecQ)
NRZ33_RS01060	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NRZ33_RS01070	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NRZ33_RS01075	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NRZ33_RS01085	COG2239	Acts as a magnesium transporter
NRZ33_RS01090	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NRZ33_RS01090	COG1648	precorrin-2 dehydrogenase activity
NRZ33_RS01095	COG2116	formate transmembrane transporter activity
NRZ33_RS01110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NRZ33_RS01115	COG0842	Transport permease protein
NRZ33_RS01120	COG0842	Transport permease protein
NRZ33_RS01125	COG1131	(ABC) transporter
NRZ33_RS01130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRZ33_RS01140	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NRZ33_RS01145	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NRZ33_RS01165	COG1595	DNA-templated transcription, initiation
NRZ33_RS01170	COG3806	Anti-sigma factor
NRZ33_RS01175	COG1968	undecaprenyl-diphosphatase activity
NRZ33_RS01180	COG0667	Aldo Keto reductase
NRZ33_RS01185	COG2017	converts alpha-aldose to the beta-anomer
NRZ33_RS01190	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NRZ33_RS01200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NRZ33_RS01205	COG1609	Transcriptional regulator
NRZ33_RS01210	COG3250	beta-galactosidase activity
NRZ33_RS01230	COG0840	transmembrane signaling receptor activity
NRZ33_RS01260	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NRZ33_RS01265	COG1288	antiporter activity
NRZ33_RS01270	COG1438	arginine binding
NRZ33_RS01275	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
NRZ33_RS01280	COG0540	Belongs to the ATCase OTCase family
NRZ33_RS01300	COG0688	phosphatidylethanolamine metabolic process
NRZ33_RS01310	COG3040	lipid binding
NRZ33_RS01315	COG2207	Transcriptional regulator
NRZ33_RS01320	COG1979	alcohol dehydrogenase
NRZ33_RS01325	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NRZ33_RS01330	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NRZ33_RS01340	COG3681	Belongs to the UPF0597 family
NRZ33_RS01350	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRZ33_RS01355	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NRZ33_RS01360	COG0564	pseudouridine synthase activity
NRZ33_RS01370	COG0542	response to heat
NRZ33_RS01375	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NRZ33_RS01380	COG2502	aspartate--ammonia ligase
NRZ33_RS01385	COG1522	sequence-specific DNA binding
NRZ33_RS01395	COG5413	integral membrane protein
NRZ33_RS01420	COG2205	protein histidine kinase activity
NRZ33_RS01430	COG2204	response regulator
NRZ33_RS01445	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
NRZ33_RS01475	COG0243	molybdopterin cofactor binding
NRZ33_RS01480	COG3005	denitrification pathway
NRZ33_RS01485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NRZ33_RS01505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NRZ33_RS01510	COG0569	domain protein
NRZ33_RS01515	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NRZ33_RS01540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NRZ33_RS01555	COG0250	Participates in transcription elongation, termination and antitermination
NRZ33_RS01560	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NRZ33_RS01565	COG0081	regulation of translation
NRZ33_RS01570	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NRZ33_RS01575	COG0222	ribosome binding
NRZ33_RS01580	COG0085	RNA polymerase activity
NRZ33_RS01585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NRZ33_RS01590	COG2964	Protein conserved in bacteria
NRZ33_RS01595	COG0251	oxidation-reduction process
NRZ33_RS01605	COG2923	Belongs to the DsrF TusC family
NRZ33_RS01610	COG2168	tRNA wobble position uridine thiolation
NRZ33_RS01615	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NRZ33_RS01620	COG0049	tRNA binding
NRZ33_RS01625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NRZ33_RS01630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NRZ33_RS01635	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NRZ33_RS01670	COG2252	PERMEase
NRZ33_RS01675	COG2376	Dihydroxyacetone kinase
NRZ33_RS01680	COG1461	Dihydroxyacetone kinase
NRZ33_RS01695	COG3284	Transcriptional regulator
NRZ33_RS01700	COG2957	Belongs to the agmatine deiminase family
NRZ33_RS01710	COG0628	permease
NRZ33_RS01715	COG0494	nUDIX hydrolase
NRZ33_RS01740	COG0753	catalase activity
NRZ33_RS01745	COG1247	-acetyltransferase
NRZ33_RS01765	COG2203	Gaf domain
NRZ33_RS01765	COG2199	diguanylate cyclase activity
NRZ33_RS01775	COG3842	ATPase activity
NRZ33_RS01785	COG1175	transmembrane transport
NRZ33_RS01810	COG0583	DNA-binding transcription factor activity
NRZ33_RS01820	COG1741	Belongs to the pirin family
NRZ33_RS01825	COG2259	Doxx family
NRZ33_RS01830	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NRZ33_RS01835	COG1074	ATP-dependent DNA helicase activity
NRZ33_RS01840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NRZ33_RS01850	COG0346	lactoylglutathione lyase activity
NRZ33_RS01890	COG3706	GGDEF domain
NRZ33_RS01895	COG4771	TonB-dependent receptor
NRZ33_RS01900	COG1278	Cold shock
NRZ33_RS01925	COG0629	single-stranded DNA binding
NRZ33_RS01930	COG2197	response regulator
NRZ33_RS01935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NRZ33_RS01975	COG3135	benzoate transporter
NRZ33_RS01980	COG1396	sequence-specific DNA binding
NRZ33_RS02015	COG2926	Belongs to the UPF0265 family
NRZ33_RS02025	COG3028	Belongs to the UPF0307 family
NRZ33_RS02030	COG0312	modulator of DNA gyrase
NRZ33_RS02035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NRZ33_RS02040	COG5007	Belongs to the BolA IbaG family
NRZ33_RS02050	COG2854	intermembrane phospholipid transfer
NRZ33_RS02055	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NRZ33_RS02060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NRZ33_RS02065	COG1127	ABC transporter
NRZ33_RS02070	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NRZ33_RS02070	COG0517	IMP dehydrogenase activity
NRZ33_RS02075	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NRZ33_RS02080	COG3117	lipopolysaccharide transmembrane transporter activity
NRZ33_RS02085	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NRZ33_RS02090	COG1137	ATPase activity
NRZ33_RS02095	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NRZ33_RS02105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ33_RS02110	COG1660	Displays ATPase and GTPase activities
NRZ33_RS02115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ33_RS02120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ33_RS02120	COG3711	transcriptional antiterminator
NRZ33_RS02135	COG3964	amidohydrolase
NRZ33_RS02165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NRZ33_RS02170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NRZ33_RS02180	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NRZ33_RS02185	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NRZ33_RS02190	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NRZ33_RS02195	COG0723	plastoquinol--plastocyanin reductase activity
NRZ33_RS02200	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NRZ33_RS02205	COG2857	Cytochrome c1
NRZ33_RS02210	COG0625	glutathione transferase activity
NRZ33_RS02215	COG2969	positive regulation of protein catabolic process
NRZ33_RS02220	COG2823	Periplasmic or secreted lipoprotein
NRZ33_RS02225	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NRZ33_RS02230	COG0792	nuclease activity
NRZ33_RS02235	COG3107	peptidoglycan biosynthetic process
NRZ33_RS02240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NRZ33_RS02250	COG2001	Belongs to the MraZ family
NRZ33_RS02255	COG0275	rRNA processing
NRZ33_RS02260	COG3116	cell division
NRZ33_RS02265	COG0768	penicillin binding
NRZ33_RS02275	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NRZ33_RS02280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NRZ33_RS02285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NRZ33_RS02290	COG0772	Belongs to the SEDS family
NRZ33_RS02295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NRZ33_RS02300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NRZ33_RS02305	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NRZ33_RS02310	COG0849	cell division
NRZ33_RS02315	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NRZ33_RS02320	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NRZ33_RS02330	COG0653	protein targeting
NRZ33_RS02340	COG0494	nUDIX hydrolase
NRZ33_RS02345	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NRZ33_RS02350	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
NRZ33_RS02365	COG1459	type II secretion system
NRZ33_RS02370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NRZ33_RS02395	COG2186	Transcriptional regulator
NRZ33_RS02400	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NRZ33_RS02405	COG0508	dehydrogenase complex catalyzes the overall conversion of
NRZ33_RS02410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NRZ33_RS02420	COG0840	transmembrane signaling receptor activity
NRZ33_RS02425	COG0840	transmembrane signaling receptor activity
NRZ33_RS02430	COG1752	Esterase of the alpha-beta hydrolase superfamily
NRZ33_RS02435	COG1049	propionate catabolic process, 2-methylcitrate cycle
NRZ33_RS02445	COG1280	lysine exporter protein (LysE YggA)
NRZ33_RS02455	COG0523	cobalamin synthesis protein
NRZ33_RS02460	COG0477	Major facilitator Superfamily
NRZ33_RS02475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NRZ33_RS02480	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NRZ33_RS02515	COG3314	Sporulation integral membrane protein YlbJ
NRZ33_RS02520	COG0835	chemotaxis
NRZ33_RS02520	COG0784	Response regulator, receiver
NRZ33_RS02530	COG1444	tRNA N-acetyltransferase activity
NRZ33_RS02555	COG1803	Methylglyoxal synthase
NRZ33_RS02570	COG0252	asparaginase activity
NRZ33_RS02590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRZ33_RS02590	COG1263	PTS System
NRZ33_RS02595	COG0366	Alpha amylase catalytic
NRZ33_RS02600	COG0110	maltose O-acetyltransferase activity
NRZ33_RS02610	COG1012	belongs to the aldehyde dehydrogenase family
NRZ33_RS02615	COG1177	transmembrane transport
NRZ33_RS02620	COG1176	ABC-type spermidine putrescine transport system, permease component I
NRZ33_RS02625	COG3842	ATPase activity
NRZ33_RS02630	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NRZ33_RS02635	COG0583	DNA-binding transcription factor activity
NRZ33_RS02640	COG1757	Na H antiporter
NRZ33_RS02680	COG0297	glycogen (starch) synthase activity
NRZ33_RS02685	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NRZ33_RS02690	COG2813	Specifically methylates the guanine in position
NRZ33_RS02695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NRZ33_RS02700	COG2203	Gaf domain
NRZ33_RS02700	COG3706	GGDEF domain
NRZ33_RS02700	COG4251	negative regulation of phosphorylation
NRZ33_RS02700	COG5001	Diguanylate cyclase
NRZ33_RS02710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRZ33_RS02720	COG2995	paraquat-inducible protein a
NRZ33_RS02725	COG3008	intermembrane lipid transfer
NRZ33_RS02725	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NRZ33_RS02730	COG3009	Protein conserved in bacteria
NRZ33_RS02745	COG3240	lipase activity
NRZ33_RS02750	COG3111	PFAM Bacterial OB fold (BOF) protein
NRZ33_RS02760	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
NRZ33_RS02765	COG1194	a g-specific adenine glycosylase
NRZ33_RS02775	COG3267	Type II secretory pathway component ExeA
NRZ33_RS02775	COG3409	Peptidoglycan-binding domain 1 protein
NRZ33_RS02780	COG0617	tRNA 3'-terminal CCA addition
NRZ33_RS02795	COG1346	cytolysis
NRZ33_RS02800	COG1380	Effector of murein hydrolase LrgA
NRZ33_RS02805	COG0583	DNA-binding transcription factor activity
NRZ33_RS02840	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NRZ33_RS02845	COG0306	phosphate transporter
NRZ33_RS02850	COG1392	Phosphate transport regulator
NRZ33_RS02865	COG1560	Kdo2-lipid A biosynthetic process
NRZ33_RS02870	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NRZ33_RS02870	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NRZ33_RS02875	COG1538	Outer membrane efflux protein
NRZ33_RS02880	COG0494	nUDIX hydrolase
NRZ33_RS02885	COG3151	Protein conserved in bacteria
NRZ33_RS02895	COG3150	esterase
NRZ33_RS02900	COG1051	belongs to the nudix hydrolase family
NRZ33_RS02915	COG1566	PFAM secretion protein HlyD family protein
NRZ33_RS02920	COG1289	transmembrane transporter activity
NRZ33_RS02940	COG0583	DNA-binding transcription factor activity
NRZ33_RS02980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRZ33_RS03000	COG0204	Acyl-transferase
NRZ33_RS03005	COG1842	Phage shock protein A
NRZ33_RS03020	COG2827	Endonuclease containing a URI domain
NRZ33_RS03030	COG2962	Rard protein
NRZ33_RS03035	COG1573	uracil-dna glycosylase
NRZ33_RS03040	COG0697	spore germination
NRZ33_RS03045	COG0583	DNA-binding transcription factor activity
NRZ33_RS03050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NRZ33_RS03055	COG1121	(ABC) transporter
NRZ33_RS03060	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
NRZ33_RS03080	COG0739	heme binding
NRZ33_RS03090	COG3068	Protein conserved in bacteria
NRZ33_RS03110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NRZ33_RS03115	COG1546	Belongs to the CinA family
NRZ33_RS03120	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NRZ33_RS03130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NRZ33_RS03135	COG0527	aspartate kinase activity
NRZ33_RS03140	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NRZ33_RS03170	COG1686	Belongs to the peptidase S11 family
NRZ33_RS03175	COG0586	Pfam SNARE associated Golgi protein
NRZ33_RS03180	COG1253	flavin adenine dinucleotide binding
NRZ33_RS03185	COG0525	valine-tRNA ligase activity
NRZ33_RS03190	COG2927	DNA polymerase III (CHI subunit)
NRZ33_RS03195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NRZ33_RS03200	COG0795	lipopolysaccharide-transporting ATPase activity
NRZ33_RS03205	COG0795	lipopolysaccharide-transporting ATPase activity
NRZ33_RS03220	COG0004	ammonium transporteR
NRZ33_RS03225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NRZ33_RS03235	COG2165	general secretion pathway protein
NRZ33_RS03240	COG0084	hydrolase, TatD family'
NRZ33_RS03245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRZ33_RS03255	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NRZ33_RS03260	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NRZ33_RS03265	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NRZ33_RS03270	COG0813	purine-nucleoside phosphorylase activity
NRZ33_RS03275	COG5002	protein histidine kinase activity
NRZ33_RS03275	COG5001	Diguanylate cyclase
NRZ33_RS03275	COG3447	MASE1 domain protein
NRZ33_RS03285	COG0560	Phosphoserine phosphatase
NRZ33_RS03310	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
NRZ33_RS03320	COG0776	regulation of translation
NRZ33_RS03335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NRZ33_RS03340	COG0735	belongs to the Fur family
NRZ33_RS03365	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NRZ33_RS03370	COG0513	Belongs to the DEAD box helicase family
NRZ33_RS03375	COG3022	response to hydroperoxide
NRZ33_RS03390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NRZ33_RS03395	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NRZ33_RS03400	COG0762	integral membrane protein
NRZ33_RS03405	COG1872	DUF167
NRZ33_RS03420	COG4166	transmembrane transport
NRZ33_RS03440	COG1024	Enoyl-CoA hydratase
NRZ33_RS03455	COG4221	oxidoreductase activity
NRZ33_RS03460	COG0442	prolyl-tRNA aminoacylation
NRZ33_RS03465	COG0840	transmembrane signaling receptor activity
NRZ33_RS03470	COG0632	four-way junction helicase activity
NRZ33_RS03475	COG2255	four-way junction helicase activity
NRZ33_RS03480	COG1271	oxidase subunit
NRZ33_RS03485	COG1294	oxidase, subunit
NRZ33_RS03490	COG4890	Cyd operon protein YbgT
NRZ33_RS03495	COG3790	cyd operon protein YbgE
NRZ33_RS03500	COG0824	Thioesterase
NRZ33_RS03505	COG0811	peptide transport
NRZ33_RS03520	COG0823	Involved in the tonB-independent uptake of proteins
NRZ33_RS03525	COG2885	chlorophyll binding
NRZ33_RS03530	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
NRZ33_RS03605	COG0840	transmembrane signaling receptor activity
NRZ33_RS03610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NRZ33_RS03615	COG0676	glucose-6-phosphate 1-epimerase activity
NRZ33_RS03620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NRZ33_RS03625	COG1640	4-alpha-glucanotransferase
NRZ33_RS03630	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NRZ33_RS03650	COG1051	belongs to the nudix hydrolase family
NRZ33_RS03655	COG2130	NADP-dependent
NRZ33_RS03660	COG1764	response to oxidative stress
NRZ33_RS03665	COG1846	Transcriptional regulator
NRZ33_RS03700	COG0561	phosphatase activity
NRZ33_RS03715	COG0733	neurotransmitter:sodium symporter activity
NRZ33_RS03725	COG0733	neurotransmitter:sodium symporter activity
NRZ33_RS03750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRZ33_RS03765	COG1794	racemase activity, acting on amino acids and derivatives
NRZ33_RS03770	COG2132	Multicopper oxidase
NRZ33_RS03770	COG2132	Multicopper oxidase
NRZ33_RS03780	COG2731	YhcH YjgK YiaL family protein
NRZ33_RS03790	COG0668	transmembrane transport
NRZ33_RS03800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NRZ33_RS03810	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
NRZ33_RS03830	COG0583	DNA-binding transcription factor activity
NRZ33_RS03835	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NRZ33_RS03845	COG0488	(ABC) transporter
NRZ33_RS03850	COG0517	IMP dehydrogenase activity
NRZ33_RS03850	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NRZ33_RS03855	COG1585	Membrane protein implicated in regulation of membrane protease activity
NRZ33_RS03860	COG0330	HflC and HflK could
NRZ33_RS03865	COG1648	precorrin-2 dehydrogenase activity
NRZ33_RS03865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NRZ33_RS03870	COG0175	sulfate reduction
NRZ33_RS03875	COG2895	sulfate adenylyltransferase (ATP) activity
NRZ33_RS03880	COG0471	metal ion transport
NRZ33_RS03880	COG3273	potassium ion transport
NRZ33_RS03885	COG0529	Catalyzes the synthesis of activated sulfate
NRZ33_RS03905	COG0625	glutathione transferase activity
NRZ33_RS03940	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
NRZ33_RS03955	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NRZ33_RS03960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NRZ33_RS03965	COG0163	prenyltransferase activity
NRZ33_RS03980	COG1131	(ABC) transporter
NRZ33_RS03985	COG0842	Transport permease protein
NRZ33_RS03990	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
NRZ33_RS03995	COG1924	4 iron, 4 sulfur cluster binding
NRZ33_RS04015	COG1823	symporter activity
NRZ33_RS04020	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NRZ33_RS04025	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NRZ33_RS04030	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NRZ33_RS04040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NRZ33_RS04045	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NRZ33_RS04050	COG1489	DNA binding
NRZ33_RS04060	COG1643	Atp-dependent helicase
NRZ33_RS04065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NRZ33_RS04070	COG0346	lactoylglutathione lyase activity
NRZ33_RS04080	COG2076	Multidrug Resistance protein
NRZ33_RS04090	COG0784	Response regulator, receiver
NRZ33_RS04090	COG3437	response regulator, receiver
NRZ33_RS04100	COG0671	phosphoesterase, PA-phosphatase related
NRZ33_RS04115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NRZ33_RS04120	COG0038	chloride channel
NRZ33_RS04130	COG0316	Belongs to the HesB IscA family
NRZ33_RS04155	COG1280	lysine exporter protein (LysE YggA)
NRZ33_RS04160	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NRZ33_RS04175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRZ33_RS04205	COG0745	RESPONSE REGULATOR receiver
NRZ33_RS04210	COG3104	oligopeptide transport
NRZ33_RS04215	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NRZ33_RS04220	COG1555	photosystem II stabilization
NRZ33_RS04230	COG2350	Protein conserved in bacteria
NRZ33_RS04235	COG2917	probably involved in intracellular septation
NRZ33_RS04240	COG0076	glutamate decarboxylase activity
NRZ33_RS04245	COG1272	protein, Hemolysin III
NRZ33_RS04250	COG0569	domain protein
NRZ33_RS04250	COG2985	domain, Protein
NRZ33_RS04260	COG0784	Response regulator, receiver
NRZ33_RS04260	COG0835	chemotaxis
NRZ33_RS04265	COG2755	lipolytic protein G-D-S-L family
NRZ33_RS04270	COG4181	ATPase activity
NRZ33_RS04275	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NRZ33_RS04280	COG1090	epimerase
NRZ33_RS04285	COG2200	EAL domain
NRZ33_RS04290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRZ33_RS04295	COG2234	aminopeptidase activity
NRZ33_RS04295	COG4935	Belongs to the peptidase S8 family
NRZ33_RS04300	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NRZ33_RS04305	COG3171	Protein conserved in bacteria
NRZ33_RS04310	COG2066	Belongs to the glutaminase family
NRZ33_RS04315	COG2897	thiosulfate sulfurtransferase activity
NRZ33_RS04325	COG1132	(ABC) transporter
NRZ33_RS04355	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
NRZ33_RS04360	COG5001	Diguanylate cyclase
NRZ33_RS04360	COG3300	MHYT domain
NRZ33_RS04380	COG4628	conserved protein (DUF2132)
NRZ33_RS04385	COG0688	phosphatidylethanolamine metabolic process
NRZ33_RS04390	COG1162	GTPase activity
NRZ33_RS04395	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NRZ33_RS04450	COG1278	Cold shock
NRZ33_RS04460	COG0840	transmembrane signaling receptor activity
NRZ33_RS04465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NRZ33_RS04515	COG0848	biopolymer transport protein
NRZ33_RS04520	COG0811	peptide transport
NRZ33_RS04525	COG0811	peptide transport
NRZ33_RS04540	COG4174	ABC transporter (Permease)
NRZ33_RS04545	COG4239	(ABC) transporter, permease
NRZ33_RS04555	COG0444	Belongs to the ABC transporter superfamily
NRZ33_RS04560	COG4608	Belongs to the ABC transporter superfamily
NRZ33_RS04565	COG2195	Cleaves the N-terminal amino acid of tripeptides
NRZ33_RS04570	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NRZ33_RS04575	COG1073	alpha beta
NRZ33_RS04590	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NRZ33_RS04625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRZ33_RS04630	COG2313	pseudouridylate synthase activity
NRZ33_RS04640	COG1858	cytochrome C peroxidase
NRZ33_RS04675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRZ33_RS04680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRZ33_RS04705	COG2986	histidine ammonia-lyase
NRZ33_RS04740	COG1028	Short-chain dehydrogenase reductase Sdr
NRZ33_RS04745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NRZ33_RS04755	COG0521	Mo-molybdopterin cofactor biosynthetic process
NRZ33_RS04765	COG2966	Psort location CytoplasmicMembrane, score
NRZ33_RS04770	COG3610	response to peptide
NRZ33_RS04780	COG4175	Glycine betaine
NRZ33_RS04785	COG4176	ABC-type proline glycine betaine transport system permease component
NRZ33_RS04790	COG2113	Glycine betaine
NRZ33_RS04795	COG0175	sulfate reduction
NRZ33_RS04800	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NRZ33_RS04805	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NRZ33_RS04810	COG0384	phenazine biosynthesis protein PhzF
NRZ33_RS04815	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NRZ33_RS04830	COG0786	glutamate:sodium symporter activity
NRZ33_RS04835	COG0252	asparaginase activity
NRZ33_RS04840	COG3139	Protein of unknown function (DUF1315)
NRZ33_RS04860	COG0616	signal peptide processing
NRZ33_RS04865	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRZ33_RS04865	COG1902	pentaerythritol trinitrate reductase activity
NRZ33_RS04870	COG0778	Nitroreductase
NRZ33_RS04890	COG2264	protein methyltransferase activity
NRZ33_RS04895	COG0604	alcohol dehydrogenase
NRZ33_RS04900	COG0583	DNA-binding transcription factor activity
NRZ33_RS04905	COG2190	(PTS) system
NRZ33_RS04905	COG1263	PTS System
NRZ33_RS04905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRZ33_RS04910	COG4145	pantothenate transmembrane transporter activity
NRZ33_RS04920	COG0439	Biotin carboxylase
NRZ33_RS04925	COG0511	ligase activity, forming carbon-carbon bonds
NRZ33_RS04930	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NRZ33_RS04935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NRZ33_RS04945	COG5001	Diguanylate cyclase
NRZ33_RS04945	COG3300	MHYT domain
NRZ33_RS04965	COG3381	protein complex oligomerization
NRZ33_RS04980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NRZ33_RS04995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NRZ33_RS05000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NRZ33_RS05000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NRZ33_RS05020	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NRZ33_RS05025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NRZ33_RS05030	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NRZ33_RS05035	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NRZ33_RS05040	COG4172	Belongs to the ABC transporter superfamily
NRZ33_RS05050	COG0601	transmembrane transport
NRZ33_RS05060	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NRZ33_RS05065	COG0142	geranyltranstransferase activity
NRZ33_RS05070	COG1722	exodeoxyribonuclease VII activity
NRZ33_RS05075	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NRZ33_RS05080	COG1360	Flagellar Motor Protein
NRZ33_RS05095	COG1534	Rna-binding protein
NRZ33_RS05100	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NRZ33_RS05110	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NRZ33_RS05115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NRZ33_RS05120	COG0149	triose-phosphate isomerase activity
NRZ33_RS05125	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NRZ33_RS05140	COG0779	Required for maturation of 30S ribosomal subunits
NRZ33_RS05145	COG0195	Participates in both transcription termination and antitermination
NRZ33_RS05150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NRZ33_RS05155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NRZ33_RS05160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NRZ33_RS05165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NRZ33_RS05170	COG1185	polyribonucleotide nucleotidyltransferase activity
NRZ33_RS05175	COG2211	Major facilitator Superfamily
NRZ33_RS05180	COG3706	GGDEF domain
NRZ33_RS05185	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NRZ33_RS05195	COG0114	fumarate hydratase activity
NRZ33_RS05205	COG1966	Carbon starvation protein
NRZ33_RS05210	COG3279	Response regulator of the LytR AlgR family
NRZ33_RS05215	COG3275	phosphorelay sensor kinase activity
NRZ33_RS05280	COG0312	modulator of DNA gyrase
NRZ33_RS05285	COG0312	modulator of DNA gyrase
NRZ33_RS05295	COG4974	Belongs to the 'phage' integrase family
NRZ33_RS05300	COG1970	mechanosensitive ion channel activity
NRZ33_RS05305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NRZ33_RS05315	COG0789	Transcriptional regulator
NRZ33_RS05330	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NRZ33_RS05335	COG3545	Serine hydrolase
NRZ33_RS05405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NRZ33_RS05410	COG0321	lipoyl(octanoyl) transferase activity
NRZ33_RS05415	COG2921	Belongs to the UPF0250 family
NRZ33_RS05420	COG1686	Belongs to the peptidase S11 family
NRZ33_RS05425	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NRZ33_RS05430	COG2951	lytic endotransglycosylase activity
NRZ33_RS05435	COG0772	Belongs to the SEDS family
NRZ33_RS05440	COG0768	penicillin binding
NRZ33_RS05445	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NRZ33_RS05450	COG0799	negative regulation of ribosome biogenesis
NRZ33_RS05455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NRZ33_RS05470	COG0495	leucyl-tRNA aminoacylation
NRZ33_RS05475	COG2888	peptidyl-tyrosine sulfation
NRZ33_RS05480	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NRZ33_RS05485	COG4535	Mg2 and Co2 transporter CorC
NRZ33_RS05490	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NRZ33_RS05495	COG1702	phosphate starvation-inducible protein PhoH
NRZ33_RS05500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NRZ33_RS05505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NRZ33_RS05510	COG1335	isochorismatase
NRZ33_RS05520	COG3706	GGDEF domain
NRZ33_RS05525	COG0583	DNA-binding transcription factor activity
NRZ33_RS05535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRZ33_RS05555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NRZ33_RS05565	COG3647	Membrane
NRZ33_RS05570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NRZ33_RS05580	COG0516	GMP reductase activity
NRZ33_RS05590	COG0642	Histidine kinase
NRZ33_RS05630	COG3214	Protein conserved in bacteria
NRZ33_RS05655	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
NRZ33_RS05660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NRZ33_RS05665	COG1053	succinate dehydrogenase
NRZ33_RS05675	COG0584	glycerophosphoryl diester phosphodiesterase
NRZ33_RS05680	COG1511	domain protein
NRZ33_RS05680	COG3264	Mechanosensitive ion channel
NRZ33_RS05690	COG0739	heme binding
NRZ33_RS05705	COG0583	DNA-binding transcription factor activity
NRZ33_RS05720	COG0840	transmembrane signaling receptor activity
NRZ33_RS05725	COG0583	DNA-binding transcription factor activity
NRZ33_RS05730	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NRZ33_RS05760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NRZ33_RS05765	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NRZ33_RS05775	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NRZ33_RS05785	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NRZ33_RS05795	COG0180	Tryptophanyl-tRNA synthetase
NRZ33_RS05810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NRZ33_RS05820	COG1012	belongs to the aldehyde dehydrogenase family
NRZ33_RS05830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRZ33_RS05840	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRZ33_RS05840	COG0674	pyruvate-flavodoxin oxidoreductase activity
NRZ33_RS05840	COG1013	pyruvate-flavodoxin oxidoreductase activity
NRZ33_RS05840	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NRZ33_RS05850	COG0366	Alpha amylase catalytic
NRZ33_RS05880	COG0471	metal ion transport
NRZ33_RS05880	COG0490	domain, Protein
NRZ33_RS05925	COG0012	GTP binding
NRZ33_RS05930	COG0193	aminoacyl-tRNA hydrolase activity
NRZ33_RS05935	COG0737	Belongs to the 5'-nucleotidase family
NRZ33_RS05940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NRZ33_RS05950	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NRZ33_RS05955	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NRZ33_RS05960	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NRZ33_RS05965	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NRZ33_RS05970	COG2890	protein-(glutamine-N5) methyltransferase activity
NRZ33_RS05980	COG2912	Transglutaminase-like superfamily
NRZ33_RS05985	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NRZ33_RS05990	COG1301	dicarboxylic acid transport
NRZ33_RS06000	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NRZ33_RS06015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NRZ33_RS06020	COG1115	amino acid carrier protein
NRZ33_RS06035	COG0714	Associated with various cellular activities
NRZ33_RS06045	COG3104	oligopeptide transport
NRZ33_RS06050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NRZ33_RS06055	COG1678	Uncharacterized ACR, COG1678
NRZ33_RS06070	COG0189	ligase activity
NRZ33_RS06075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NRZ33_RS06085	COG3091	SprT-like family
NRZ33_RS06095	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NRZ33_RS06115	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NRZ33_RS06120	COG0739	heme binding
NRZ33_RS06125	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NRZ33_RS06130	COG3408	Glycogen debranching enzyme
NRZ33_RS06130	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
NRZ33_RS06140	COG1881	PFAM PEBP family protein
NRZ33_RS06145	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NRZ33_RS06150	COG0583	DNA-binding transcription factor activity
NRZ33_RS06160	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NRZ33_RS06170	COG0583	DNA-binding transcription factor activity
NRZ33_RS06175	COG1028	Short-chain dehydrogenase reductase Sdr
NRZ33_RS06180	COG0616	signal peptide processing
NRZ33_RS06185	COG3724	N-succinylarginine dihydrolase activity
NRZ33_RS06205	COG0840	transmembrane signaling receptor activity
NRZ33_RS06215	COG2971	BadF BadG BcrA BcrD
NRZ33_RS06225	COG4608	Belongs to the ABC transporter superfamily
NRZ33_RS06230	COG0444	Belongs to the ABC transporter superfamily
NRZ33_RS06235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRZ33_RS06240	COG0601	transmembrane transport
NRZ33_RS06245	COG4166	transmembrane transport
NRZ33_RS06250	COG0784	Response regulator, receiver
NRZ33_RS06250	COG2205	protein histidine kinase activity
NRZ33_RS06280	COG3220	belongs to the UPF0276 family
NRZ33_RS06315	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NRZ33_RS06320	COG1289	transmembrane transporter activity
NRZ33_RS06325	COG0303	'Molybdopterin
NRZ33_RS06330	COG0746	molybdenum cofactor guanylyltransferase activity
NRZ33_RS06340	COG4662	Binding-protein-dependent transport system inner membrane component
NRZ33_RS06350	COG2204	response regulator
NRZ33_RS06355	COG3852	Histidine kinase
NRZ33_RS06360	COG1910	domain protein
NRZ33_RS06365	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NRZ33_RS06400	COG3383	formate dehydrogenase (NAD+) activity
NRZ33_RS06400	COG3383	formate dehydrogenase (NAD+) activity
NRZ33_RS06405	COG0437	4 iron, 4 sulfur cluster binding
NRZ33_RS06420	COG0281	malic enzyme
NRZ33_RS06440	COG2706	6-phosphogluconolactonase activity
NRZ33_RS06450	COG1196	nuclear chromosome segregation
NRZ33_RS06450	COG3264	Mechanosensitive ion channel
NRZ33_RS06455	COG0469	pyruvate kinase activity
NRZ33_RS06470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NRZ33_RS06470	COG4651	solute:proton antiporter activity
NRZ33_RS06480	COG2974	May be involved in recombination
NRZ33_RS06490	COG0420	3'-5' exonuclease activity
NRZ33_RS06495	COG0419	ATPase involved in DNA repair
NRZ33_RS06505	COG3038	cytochrome b561
NRZ33_RS06520	COG2190	(PTS) system
NRZ33_RS06530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ33_RS06535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NRZ33_RS06540	COG0542	response to heat
NRZ33_RS06555	COG2770	Histidine kinase
NRZ33_RS06555	COG3437	response regulator, receiver
NRZ33_RS06560	COG1720	tRNA m6t6A37 methyltransferase activity
NRZ33_RS06580	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NRZ33_RS06585	COG4988	ABC transporter
NRZ33_RS06600	COG0745	RESPONSE REGULATOR receiver
NRZ33_RS06610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NRZ33_RS06625	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
NRZ33_RS06630	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
NRZ33_RS06640	COG0083	homoserine kinase activity
NRZ33_RS06645	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NRZ33_RS06650	COG4319	ketosteroid isomerase
NRZ33_RS06665	COG0488	(ABC) transporter
NRZ33_RS06680	COG0813	purine-nucleoside phosphorylase activity
NRZ33_RS06695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ33_RS06695	COG2205	protein histidine kinase activity
NRZ33_RS06700	COG3384	dioxygenase
NRZ33_RS06710	COG1283	sodium-dependent phosphate transmembrane transporter activity
NRZ33_RS06720	COG0531	amino acid
NRZ33_RS06730	COG0531	amino acid
NRZ33_RS06750	COG1917	Cupin 2, conserved barrel domain protein
NRZ33_RS06750	COG1396	sequence-specific DNA binding
NRZ33_RS06755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRZ33_RS06785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NRZ33_RS06790	COG2375	cellular response to nickel ion
NRZ33_RS06800	COG0577	efflux transmembrane transporter activity
NRZ33_RS06800	COG1136	(ABC) transporter
NRZ33_RS06805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRZ33_RS06815	COG1227	inorganic diphosphatase activity
NRZ33_RS06820	COG0497	DNA recombination
NRZ33_RS06825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NRZ33_RS06830	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NRZ33_RS06835	COG0443	Heat shock 70 kDa protein
NRZ33_RS06840	COG0484	heat shock protein binding
NRZ33_RS06870	COG1285	pathogenesis
NRZ33_RS06880	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRZ33_RS06920	COG0095	Lipoate-protein ligase
NRZ33_RS06940	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRZ33_RS06945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRZ33_RS06965	COG0708	Exodeoxyribonuclease III
NRZ33_RS06980	COG2211	Major facilitator Superfamily
NRZ33_RS07025	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NRZ33_RS07030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NRZ33_RS07035	COG1845	cytochrome c oxidase, subunit III
NRZ33_RS07040	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NRZ33_RS07045	COG0109	protoheme IX farnesyltransferase activity
NRZ33_RS07050	COG2814	Major facilitator Superfamily
NRZ33_RS07060	COG2175	clavaminate synthase activity
NRZ33_RS07065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NRZ33_RS07070	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NRZ33_RS07075	COG4521	taurine ABC transporter
NRZ33_RS07085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRZ33_RS07105	COG1988	membrane-bound metal-dependent
NRZ33_RS07130	COG0159	tryptophan synthase activity
NRZ33_RS07135	COG0133	tryptophan synthase activity
NRZ33_RS07140	COG0134	indole-3-glycerol-phosphate synthase activity
NRZ33_RS07140	COG0135	phosphoribosylanthranilate isomerase activity
NRZ33_RS07145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NRZ33_RS07150	COG0512	Glutamine amidotransferase of anthranilate synthase
NRZ33_RS07150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NRZ33_RS07155	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NRZ33_RS07165	COG0009	L-threonylcarbamoyladenylate synthase
NRZ33_RS07175	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NRZ33_RS07185	COG1946	Acyl-CoA thioesterase
NRZ33_RS07200	COG1309	transcriptional regulator
NRZ33_RS07205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRZ33_RS07210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRZ33_RS07225	COG1091	dTDP-4-dehydrorhamnose reductase activity
NRZ33_RS07240	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NRZ33_RS07245	COG0454	-acetyltransferase
NRZ33_RS07245	COG0456	acetyltransferase
NRZ33_RS07260	COG1215	transferase activity, transferring glycosyl groups
NRZ33_RS07265	COG2226	methyltransferase
NRZ33_RS07290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NRZ33_RS07305	COG1940	carbohydrate kinase activity
NRZ33_RS07305	COG1846	Transcriptional regulator
NRZ33_RS07310	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NRZ33_RS07315	COG0363	glucosamine-6-phosphate deaminase activity
NRZ33_RS07320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRZ33_RS07320	COG1263	PTS System
NRZ33_RS07320	COG2190	(PTS) system
NRZ33_RS07330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NRZ33_RS07335	COG0735	belongs to the Fur family
NRZ33_RS07345	COG0716	FMN binding
NRZ33_RS07360	COG0596	Alpha beta hydrolase
NRZ33_RS07365	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
NRZ33_RS07370	COG0033	Phosphoglucomutase
NRZ33_RS07380	COG1846	Transcriptional regulator
NRZ33_RS07385	COG2951	lytic endotransglycosylase activity
NRZ33_RS07390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NRZ33_RS07395	COG4136	ATPase activity
NRZ33_RS07405	COG4134	Bacterial extracellular solute-binding protein
NRZ33_RS07415	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NRZ33_RS07425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NRZ33_RS07430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NRZ33_RS07440	COG0729	surface antigen
NRZ33_RS07445	COG2911	Protein conserved in bacteria
NRZ33_RS07465	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NRZ33_RS07475	COG0741	lytic transglycosylase activity
NRZ33_RS07490	COG1607	acyl-coa hydrolase
NRZ33_RS07500	COG3021	interspecies interaction between organisms
NRZ33_RS07505	COG0741	lytic transglycosylase activity
NRZ33_RS07505	COG1388	LysM domain
NRZ33_RS07510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRZ33_RS07515	COG2226	methyltransferase
NRZ33_RS07520	COG0328	RNA-DNA hybrid ribonuclease activity
NRZ33_RS07535	COG0784	Response regulator, receiver
NRZ33_RS07535	COG3437	response regulator, receiver
NRZ33_RS07540	COG1960	acyl-CoA dehydrogenase activity
NRZ33_RS07545	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NRZ33_RS07550	COG0121	glutamine amidotransferase
NRZ33_RS07580	COG2197	response regulator
NRZ33_RS07585	COG3850	Histidine kinase
NRZ33_RS07590	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NRZ33_RS07595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRZ33_RS07595	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRZ33_RS07605	COG0243	molybdopterin cofactor binding
NRZ33_RS07610	COG0437	4 iron, 4 sulfur cluster binding
NRZ33_RS07615	COG0348	domain, Protein
NRZ33_RS07625	COG3005	denitrification pathway
NRZ33_RS07630	COG0521	Mo-molybdopterin cofactor biosynthetic process
NRZ33_RS07635	COG0315	cyclic pyranopterin monophosphate synthase activity
NRZ33_RS07640	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NRZ33_RS07645	COG0314	molybdopterin synthase activity
NRZ33_RS07660	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NRZ33_RS07665	COG2267	carboxylic ester hydrolase activity
NRZ33_RS07670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NRZ33_RS07680	COG0302	gtp cyclohydrolase
NRZ33_RS07685	COG0840	transmembrane signaling receptor activity
NRZ33_RS07690	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NRZ33_RS07700	COG0583	DNA-binding transcription factor activity
NRZ33_RS07730	COG2195	Cleaves the N-terminal amino acid of tripeptides
NRZ33_RS07745	COG1166	arginine decarboxylase activity
NRZ33_RS07765	COG0814	amino acid
NRZ33_RS07775	COG3681	Belongs to the UPF0597 family
NRZ33_RS07780	COG2964	Protein conserved in bacteria
NRZ33_RS07790	COG1403	HNH endonuclease
NRZ33_RS07815	COG1187	pseudouridine synthase activity
NRZ33_RS07825	COG2807	transmembrane transport
NRZ33_RS07835	COG0583	DNA-binding transcription factor activity
NRZ33_RS07840	COG2271	Major facilitator Superfamily
NRZ33_RS07865	COG2979	Protein of unknown function (DUF533)
NRZ33_RS07875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRZ33_RS07885	COG1294	oxidase, subunit
NRZ33_RS07895	COG2814	Major facilitator Superfamily
NRZ33_RS07900	COG0656	L-ascorbic acid biosynthetic process
NRZ33_RS07925	COG0583	DNA-binding transcription factor activity
NRZ33_RS07930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NRZ33_RS07935	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NRZ33_RS07940	COG2271	Major facilitator Superfamily
NRZ33_RS07945	COG1349	DNA-binding transcription factor activity
NRZ33_RS07960	COG0584	glycerophosphoryl diester phosphodiesterase
NRZ33_RS07965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NRZ33_RS07970	COG1605	Chorismate mutase
NRZ33_RS07970	COG0287	Prephenate dehydrogenase
NRZ33_RS07975	COG0583	DNA-binding transcription factor activity
NRZ33_RS07980	COG3085	chromosome segregation
NRZ33_RS07985	COG4574	serine-type endopeptidase inhibitor activity
NRZ33_RS08005	COG1770	oligopeptidase
NRZ33_RS08010	COG4771	TonB-dependent receptor
NRZ33_RS08015	COG3083	sulfuric ester hydrolase activity
NRZ33_RS08020	COG3082	Protein of unknown function (DUF1414)
NRZ33_RS08025	COG3081	Nucleoid-associated protein
NRZ33_RS08035	COG1175	transmembrane transport
NRZ33_RS08040	COG3833	ABC-type maltose transport systems, permease component
NRZ33_RS08045	COG3842	ATPase activity
NRZ33_RS08070	COG0425	Belongs to the sulfur carrier protein TusA family
NRZ33_RS08075	COG4783	chaperone-mediated protein folding
NRZ33_RS08085	COG1393	Belongs to the ArsC family
NRZ33_RS08100	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
NRZ33_RS08110	COG2431	L-lysine efflux transmembrane transporter activity
NRZ33_RS08120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ33_RS08140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NRZ33_RS08150	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRZ33_RS08155	COG2373	Large extracellular alpha-helical protein
NRZ33_RS08160	COG4953	penicillin-binding protein 1C
NRZ33_RS08170	COG0301	tRNA thio-modification
NRZ33_RS08170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NRZ33_RS08185	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NRZ33_RS08230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NRZ33_RS08250	COG0483	inositol monophosphate 1-phosphatase activity
NRZ33_RS08260	COG0625	glutathione transferase activity
NRZ33_RS08265	COG2814	Major facilitator Superfamily
NRZ33_RS08285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NRZ33_RS08290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NRZ33_RS08295	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NRZ33_RS08300	COG0509	glycine decarboxylation via glycine cleavage system
NRZ33_RS08305	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NRZ33_RS08305	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NRZ33_RS08310	COG0640	Transcriptional regulator
NRZ33_RS08315	COG0798	PFAM Bile acid sodium symporter
NRZ33_RS08320	COG1393	Belongs to the ArsC family
NRZ33_RS08335	COG3852	Histidine kinase
NRZ33_RS08345	COG3634	alkyl hydroperoxide reductase activity
NRZ33_RS08355	COG0517	IMP dehydrogenase activity
NRZ33_RS08360	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NRZ33_RS08365	COG0343	queuine tRNA-ribosyltransferase activity
NRZ33_RS08370	COG1862	Preprotein translocase
NRZ33_RS08375	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRZ33_RS08380	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRZ33_RS08385	COG2897	thiosulfate sulfurtransferase activity
NRZ33_RS08395	COG0826	peptidase U32
NRZ33_RS08400	COG0826	peptidase U32
NRZ33_RS08405	COG3154	lipid carrier protein
NRZ33_RS08425	COG1104	cysteine desulfurase activity
NRZ33_RS08430	COG0822	iron-sulfur transferase activity
NRZ33_RS08440	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NRZ33_RS08445	COG0443	Heat shock 70 kDa protein
NRZ33_RS08450	COG0633	Ferredoxin
NRZ33_RS08460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NRZ33_RS08465	COG0105	UTP biosynthetic process
NRZ33_RS08470	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NRZ33_RS08490	COG0124	histidyl-tRNA synthetase
NRZ33_RS08495	COG2976	Protein conserved in bacteria
NRZ33_RS08500	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NRZ33_RS08505	COG1160	GTP binding
NRZ33_RS08510	COG1645	bacterial-type flagellum-dependent swarming motility
NRZ33_RS08515	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NRZ33_RS08520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NRZ33_RS08520	COG0047	phosphoribosylformylglycinamidine synthase activity
NRZ33_RS08525	COG1007	ATP synthesis coupled electron transport
NRZ33_RS08530	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRZ33_RS08540	COG0713	ATP synthesis coupled electron transport
NRZ33_RS08545	COG0839	Belongs to the complex I subunit 6 family
NRZ33_RS08550	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRZ33_RS08555	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NRZ33_RS08560	COG1034	ATP synthesis coupled electron transport
NRZ33_RS08575	COG0649	NAD binding
NRZ33_RS08575	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRZ33_RS08580	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRZ33_RS08585	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRZ33_RS08590	COG1360	Flagellar Motor Protein
NRZ33_RS08595	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NRZ33_RS08615	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NRZ33_RS08635	COG0724	RNA recognition motif
NRZ33_RS08640	COG4989	oxidoreductase activity
NRZ33_RS08665	COG3437	response regulator, receiver
NRZ33_RS08670	COG0583	DNA-binding transcription factor activity
NRZ33_RS08680	COG3300	MHYT domain
NRZ33_RS08680	COG5001	Diguanylate cyclase
NRZ33_RS08685	COG0778	Nitroreductase
NRZ33_RS08705	COG0583	DNA-binding transcription factor activity
NRZ33_RS08715	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NRZ33_RS08720	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NRZ33_RS08725	COG0539	negative regulation of cytoplasmic translation
NRZ33_RS08730	COG0776	regulation of translation
NRZ33_RS08740	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NRZ33_RS08760	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NRZ33_RS08765	COG0602	queuosine metabolic process
NRZ33_RS08770	COG3530	Putative quorum-sensing-regulated virulence factor
NRZ33_RS08775	COG2096	Adenosyltransferase
NRZ33_RS08780	COG2916	Histone family protein nucleoid-structuring protein H-NS
NRZ33_RS08785	COG1757	Na H antiporter
NRZ33_RS08790	COG1435	thymidine kinase activity
NRZ33_RS08825	COG3501	Rhs element vgr protein
NRZ33_RS08900	COG3829	transcription factor binding
NRZ33_RS08965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NRZ33_RS08970	COG1278	Cold shock
NRZ33_RS08975	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NRZ33_RS08980	COG0542	response to heat
NRZ33_RS08985	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NRZ33_RS08990	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
NRZ33_RS08995	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NRZ33_RS09000	COG3134	Outer membrane lipoprotein
NRZ33_RS09005	COG3706	GGDEF domain
NRZ33_RS09010	COG0492	ferredoxin-NADP+ reductase activity
NRZ33_RS09015	COG0686	Belongs to the AlaDH PNT family
NRZ33_RS09025	COG0531	amino acid
NRZ33_RS09025	COG1674	ftsk spoiiie
NRZ33_RS09030	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NRZ33_RS09035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NRZ33_RS09040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NRZ33_RS09045	COG1286	toxin biosynthetic process
NRZ33_RS09050	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NRZ33_RS09060	COG4172	Belongs to the ABC transporter superfamily
NRZ33_RS09070	COG4171	peptide transport system, permease
NRZ33_RS09075	COG4168	peptide transport system, permease
NRZ33_RS09085	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NRZ33_RS09090	COG1842	Phage shock protein A
NRZ33_RS09105	COG3106	COG3106 Predicted ATPase
NRZ33_RS09110	COG3768	UPF0283 membrane protein
NRZ33_RS09120	COG2154	pterin-4-alpha-carbinolamine dehydratase
NRZ33_RS09140	COG2199	diguanylate cyclase activity
NRZ33_RS09145	COG2885	chlorophyll binding
NRZ33_RS09150	COG0861	Integral membrane protein TerC family
NRZ33_RS09165	COG1022	Amp-dependent synthetase and ligase
NRZ33_RS09170	COG0295	cytidine deaminase activity
NRZ33_RS09175	COG1346	cytolysis
NRZ33_RS09180	COG1380	Effector of murein hydrolase LrgA
NRZ33_RS09185	COG3345	alpha-galactosidase
NRZ33_RS09195	COG2925	Exonuclease
NRZ33_RS09200	COG2160	L-arabinose isomerase activity
NRZ33_RS09210	COG1069	ribulokinase activity
NRZ33_RS09215	COG1879	ABC-type sugar transport system periplasmic component
NRZ33_RS09225	COG1172	Belongs to the binding-protein-dependent transport system permease family
NRZ33_RS09235	COG0583	DNA-binding transcription factor activity
NRZ33_RS09245	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NRZ33_RS09250	COG0254	rRNA binding
NRZ33_RS09265	COG1451	nucleotide metabolic process
NRZ33_RS09280	COG3069	C4-dicarboxylate transmembrane transporter activity
NRZ33_RS09290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRZ33_RS09290	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NRZ33_RS09295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NRZ33_RS09320	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NRZ33_RS09325	COG1053	succinate dehydrogenase
NRZ33_RS09335	COG0567	Dehydrogenase, E1 component
NRZ33_RS09340	COG0508	dehydrogenase complex catalyzes the overall conversion of
NRZ33_RS09345	COG0045	succinate-CoA ligase (ADP-forming) activity
NRZ33_RS09350	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NRZ33_RS09360	COG2983	Belongs to the UPF0260 family
NRZ33_RS09365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRZ33_RS09375	COG3842	ATPase activity
NRZ33_RS09380	COG1840	ABC-type Fe3 transport system, periplasmic component
NRZ33_RS09390	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NRZ33_RS09400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRZ33_RS09405	COG1882	Formate acetyltransferase
NRZ33_RS09410	COG2116	formate transmembrane transporter activity
NRZ33_RS09415	COG1944	ATP diphosphatase activity
NRZ33_RS09425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NRZ33_RS09430	COG0612	Peptidase, M16
NRZ33_RS09435	COG0626	cystathionine gamma-synthase activity
NRZ33_RS09445	COG2910	NAD(P)H-binding
NRZ33_RS09450	COG0583	DNA-binding transcription factor activity
NRZ33_RS09460	COG4977	sequence-specific DNA binding
NRZ33_RS09465	COG4774	siderophore transport
NRZ33_RS09480	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NRZ33_RS09490	COG0516	GMP reductase activity
NRZ33_RS09490	COG0517	IMP dehydrogenase activity
NRZ33_RS09505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRZ33_RS09510	COG3046	protein related to deoxyribodipyrimidine photolyase
NRZ33_RS09520	COG3033	Beta-eliminating lyase
NRZ33_RS09525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NRZ33_RS09535	COG1120	ATPase activity
NRZ33_RS09540	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRZ33_RS09545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRZ33_RS09550	COG4771	TonB-dependent receptor
NRZ33_RS09590	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NRZ33_RS09595	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NRZ33_RS09600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NRZ33_RS09615	COG1570	exodeoxyribonuclease VII activity
NRZ33_RS09640	COG3158	transport of potassium into the cell
NRZ33_RS09645	COG0516	GMP reductase activity
NRZ33_RS09645	COG0517	IMP dehydrogenase activity
NRZ33_RS09650	COG0519	Catalyzes the synthesis of GMP from XMP
NRZ33_RS09650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NRZ33_RS09690	COG2062	phosphohistidine phosphatase, SixA
NRZ33_RS09700	COG0697	spore germination
NRZ33_RS09705	COG4166	transmembrane transport
NRZ33_RS09710	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NRZ33_RS09715	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NRZ33_RS09725	COG4591	ABC-type transport system involved in lipoprotein release permease component
NRZ33_RS09730	COG1136	(ABC) transporter
NRZ33_RS09735	COG4591	ABC-type transport system involved in lipoprotein release permease component
NRZ33_RS09740	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
NRZ33_RS09750	COG0544	peptidyl-prolyl cis-trans isomerase activity
NRZ33_RS09755	COG0740	serine-type endopeptidase activity
NRZ33_RS09760	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NRZ33_RS09765	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NRZ33_RS09770	COG0776	regulation of translation
NRZ33_RS09775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NRZ33_RS09780	COG0488	(ABC) transporter
NRZ33_RS09785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NRZ33_RS09790	COG3162	membrane
NRZ33_RS09805	COG1250	3-hydroxyacyl-CoA dehydrogenase
NRZ33_RS09805	COG1024	Enoyl-CoA hydratase
NRZ33_RS09845	COG1115	amino acid carrier protein
NRZ33_RS09860	COG1584	GPR1 FUN34 yaaH family protein
NRZ33_RS09895	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NRZ33_RS09900	COG1960	acyl-CoA dehydrogenase activity
NRZ33_RS09910	COG1960	acyl-CoA dehydrogenase activity
NRZ33_RS09915	COG1024	Enoyl-CoA hydratase
NRZ33_RS09920	COG1024	Enoyl-CoA hydratase
NRZ33_RS09930	COG1028	Short-chain dehydrogenase reductase Sdr
NRZ33_RS09940	COG0730	response to heat
NRZ33_RS09975	COG0583	DNA-binding transcription factor activity
NRZ33_RS09980	COG2723	6-phospho-beta-galactosidase activity
NRZ33_RS09985	COG5001	Diguanylate cyclase
NRZ33_RS09985	COG3300	MHYT domain
NRZ33_RS09995	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NRZ33_RS10005	COG0583	DNA-binding transcription factor activity
NRZ33_RS10020	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NRZ33_RS10025	COG0673	inositol 2-dehydrogenase activity
NRZ33_RS10030	COG0583	DNA-binding transcription factor activity
NRZ33_RS10040	COG1560	Kdo2-lipid A biosynthetic process
NRZ33_RS10045	COG1560	Kdo2-lipid A biosynthetic process
NRZ33_RS10070	COG0417	DNA replication proofreading
NRZ33_RS10100	COG0534	Mate efflux family protein
NRZ33_RS10110	COG0307	riboflavin synthase, alpha
NRZ33_RS10120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRZ33_RS10125	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NRZ33_RS10130	COG0697	spore germination
NRZ33_RS10135	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NRZ33_RS10180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NRZ33_RS10185	COG3099	Belongs to the UPF0263 family
NRZ33_RS10190	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NRZ33_RS10195	COG2894	cell division
NRZ33_RS10200	COG0850	regulation of cytokinetic process
NRZ33_RS10205	COG3100	YcgL domain-containing protein
NRZ33_RS10215	COG1760	l-serine dehydratase
NRZ33_RS10220	COG1760	l-serine dehydratase
NRZ33_RS10225	COG3123	guanosine phosphorylase activity
NRZ33_RS10245	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NRZ33_RS10250	COG2067	long-chain fatty acid transport protein
NRZ33_RS10265	COG1595	DNA-templated transcription, initiation
NRZ33_RS10295	COG0714	Associated with various cellular activities
NRZ33_RS10300	COG0183	Belongs to the thiolase family
NRZ33_RS10305	COG1250	3-hydroxyacyl-CoA dehydrogenase
NRZ33_RS10305	COG1024	Enoyl-CoA hydratase
NRZ33_RS10325	COG3829	transcription factor binding
NRZ33_RS10330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NRZ33_RS10335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NRZ33_RS10340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NRZ33_RS10350	COG0549	Belongs to the carbamate kinase family
NRZ33_RS10355	COG0697	spore germination
NRZ33_RS10360	COG3608	succinylglutamate desuccinylase aspartoacylase
NRZ33_RS10360	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NRZ33_RS10365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NRZ33_RS10370	COG2068	MobA-Related Protein
NRZ33_RS10375	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRZ33_RS10375	COG0493	'glutamate synthase
NRZ33_RS10380	COG0402	S-adenosylhomocysteine deaminase activity
NRZ33_RS10385	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NRZ33_RS10390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NRZ33_RS10390	COG2080	2 iron, 2 sulfur cluster binding
NRZ33_RS10395	COG2233	PERMEase
NRZ33_RS10400	COG0402	S-adenosylhomocysteine deaminase activity
NRZ33_RS10405	COG2252	PERMEase
NRZ33_RS10410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NRZ33_RS10415	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NRZ33_RS10420	COG2080	2 iron, 2 sulfur cluster binding
NRZ33_RS10430	COG3134	Outer membrane lipoprotein
NRZ33_RS10440	COG1288	antiporter activity
NRZ33_RS10445	COG0318	PFAM AMP-dependent synthetase and ligase
NRZ33_RS10450	COG2378	regulation of single-species biofilm formation
NRZ33_RS10460	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NRZ33_RS10460	COG0140	phosphoribosyl-ATP diphosphatase activity
NRZ33_RS10465	COG0107	imidazoleglycerol-phosphate synthase activity
NRZ33_RS10470	COG2205	protein histidine kinase activity
NRZ33_RS10470	COG0784	Response regulator, receiver
NRZ33_RS10470	COG2198	Histidine kinase
NRZ33_RS10475	COG2199	diguanylate cyclase activity
NRZ33_RS10480	COG3437	response regulator, receiver
NRZ33_RS10485	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NRZ33_RS10490	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NRZ33_RS10495	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NRZ33_RS10495	COG0131	Imidazoleglycerol-phosphate dehydratase
NRZ33_RS10500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NRZ33_RS10505	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NRZ33_RS10510	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NRZ33_RS10520	COG1199	ATP-dependent helicase activity
NRZ33_RS10525	COG1214	PFAM Peptidase M22, glycoprotease
NRZ33_RS10535	COG0596	Alpha beta hydrolase
NRZ33_RS10535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NRZ33_RS10535	COG2226	methyltransferase
NRZ33_RS10540	COG0318	PFAM AMP-dependent synthetase and ligase
NRZ33_RS10560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NRZ33_RS10565	COG2832	Protein of unknown function (DUF454)
NRZ33_RS10570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NRZ33_RS10580	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NRZ33_RS10595	COG0517	IMP dehydrogenase activity
NRZ33_RS10595	COG0617	tRNA 3'-terminal CCA addition
NRZ33_RS10595	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NRZ33_RS10600	COG1643	Atp-dependent helicase
NRZ33_RS10610	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NRZ33_RS10620	COG3437	response regulator, receiver
NRZ33_RS10625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRZ33_RS10630	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
NRZ33_RS10635	COG0709	Synthesizes selenophosphate from selenide and ATP
NRZ33_RS10650	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NRZ33_RS10660	COG1254	Belongs to the acylphosphatase family
NRZ33_RS10665	COG0625	glutathione transferase activity
NRZ33_RS10670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRZ33_RS10670	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRZ33_RS10675	COG0489	protein tyrosine kinase activity
NRZ33_RS10680	COG0572	uridine kinase
NRZ33_RS10685	COG0717	Belongs to the dCTP deaminase family
NRZ33_RS10690	COG0306	phosphate transporter
NRZ33_RS10695	COG1530	ribonuclease E activity
NRZ33_RS10700	COG0564	pseudouridine synthase activity
NRZ33_RS10710	COG0424	maF-like protein
NRZ33_RS10715	COG2814	Major facilitator Superfamily
NRZ33_RS10730	COG1399	metal-binding, possibly nucleic acid-binding protein
NRZ33_RS10735	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NRZ33_RS10740	COG0416	fatty acid biosynthetic process
NRZ33_RS10745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NRZ33_RS10755	COG1028	Short-chain dehydrogenase reductase Sdr
NRZ33_RS10760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRZ33_RS10770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NRZ33_RS10775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NRZ33_RS10780	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NRZ33_RS10785	COG0470	DNA polymerase III
NRZ33_RS10790	COG0084	hydrolase, TatD family'
NRZ33_RS10810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NRZ33_RS10810	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
NRZ33_RS10815	COG3008	intermembrane lipid transfer
NRZ33_RS10820	COG2995	paraquat-inducible protein a
NRZ33_RS10830	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NRZ33_RS10835	COG0372	Belongs to the citrate synthase family
NRZ33_RS10880	COG4221	oxidoreductase activity
NRZ33_RS10890	COG3141	response to X-ray
NRZ33_RS10910	COG4128	Pfam Zonular occludens toxin
NRZ33_RS10950	COG1067	ATP-dependent peptidase activity
NRZ33_RS10955	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NRZ33_RS10970	COG0488	(ABC) transporter
NRZ33_RS10980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NRZ33_RS10980	COG0116	Belongs to the methyltransferase superfamily
NRZ33_RS10990	COG0167	dihydroorotate dehydrogenase activity
NRZ33_RS10995	COG2902	Dehydrogenase
NRZ33_RS11005	COG0308	aminopeptidase N
NRZ33_RS11015	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
NRZ33_RS11020	COG1956	GAF domain-containing protein
NRZ33_RS11030	COG3278	Belongs to the heme-copper respiratory oxidase family
NRZ33_RS11045	COG2010	Cytochrome c
NRZ33_RS11070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NRZ33_RS11075	COG0589	response to stress
NRZ33_RS11080	COG0037	tRNA processing
NRZ33_RS11100	COG1869	D-ribose catabolic process
NRZ33_RS11105	COG1129	ABC transporter
NRZ33_RS11110	COG1172	Belongs to the binding-protein-dependent transport system permease family
NRZ33_RS11115	COG1879	ABC-type sugar transport system periplasmic component
NRZ33_RS11120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRZ33_RS11125	COG1609	Transcriptional regulator
NRZ33_RS11130	COG3300	MHYT domain
NRZ33_RS11130	COG5001	Diguanylate cyclase
NRZ33_RS11160	COG0776	regulation of translation
NRZ33_RS11165	COG0072	phenylalanine-tRNA ligase activity
NRZ33_RS11165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRZ33_RS11170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NRZ33_RS11175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NRZ33_RS11180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NRZ33_RS11185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NRZ33_RS11190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NRZ33_RS11215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NRZ33_RS11225	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NRZ33_RS11230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NRZ33_RS11235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NRZ33_RS11240	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
NRZ33_RS11245	COG3313	Fe-S protein
NRZ33_RS11255	COG3716	PTS system mannose fructose sorbose family IID component
NRZ33_RS11260	COG3715	PTS system
NRZ33_RS11265	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRZ33_RS11265	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ33_RS11280	COG1609	Transcriptional regulator
NRZ33_RS11285	COG2140	Oxalate decarboxylase
NRZ33_RS11290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRZ33_RS11290	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NRZ33_RS11290	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRZ33_RS11295	COG1105	Belongs to the carbohydrate kinase PfkB family
NRZ33_RS11300	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ33_RS11300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ33_RS11305	COG1609	Transcriptional regulator
NRZ33_RS11310	COG0814	amino acid
NRZ33_RS11320	COG5654	RES domain protein
NRZ33_RS11325	COG0513	Belongs to the DEAD box helicase family
NRZ33_RS11335	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NRZ33_RS11340	COG2890	protein-(glutamine-N5) methyltransferase activity
NRZ33_RS11345	COG2840	Smr protein MutS2
NRZ33_RS11355	COG3706	GGDEF domain
NRZ33_RS11360	COG0588	phosphoglycerate mutase activity
NRZ33_RS11385	COG0740	serine-type endopeptidase activity
NRZ33_RS11395	COG2824	Alkylphosphonate utilization operon protein PhnA
NRZ33_RS11405	COG0384	phenazine biosynthesis protein PhzF
NRZ33_RS11435	COG0242	peptide deformylase activity
NRZ33_RS11455	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NRZ33_RS11460	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
NRZ33_RS11470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NRZ33_RS11475	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NRZ33_RS11485	COG0205	6-phosphofructokinase activity
NRZ33_RS11490	COG1473	amidohydrolase
NRZ33_RS11495	COG1011	Hydrolase
NRZ33_RS11500	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NRZ33_RS11550	COG3593	DNA synthesis involved in DNA repair
NRZ33_RS11570	COG0583	DNA-binding transcription factor activity
NRZ33_RS11575	COG0730	response to heat
NRZ33_RS11580	COG3148	PFAM DTW domain containing protein
NRZ33_RS11590	COG1181	Belongs to the D-alanine--D-alanine ligase family
NRZ33_RS11600	COG0386	Belongs to the glutathione peroxidase family
NRZ33_RS11605	COG0513	Belongs to the DEAD box helicase family
NRZ33_RS11610	COG0456	acetyltransferase
NRZ33_RS11620	COG1742	UPF0060 membrane protein
NRZ33_RS11650	COG2329	Antibiotic biosynthesis monooxygenase
NRZ33_RS11655	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
NRZ33_RS11675	COG3243	poly(R)-hydroxyalkanoic acid synthase
NRZ33_RS11685	COG2501	S4 domain
NRZ33_RS11695	COG1132	(ABC) transporter
NRZ33_RS11700	COG1132	(ABC) transporter
NRZ33_RS11710	COG3118	belongs to the thioredoxin family
NRZ33_RS11715	COG0471	metal ion transport
NRZ33_RS11720	COG0058	SHG alpha-glucan phosphorylase activity
NRZ33_RS11750	COG0814	amino acid
NRZ33_RS11755	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
NRZ33_RS11760	COG0514	ATP-dependent DNA helicase (RecQ)
NRZ33_RS11765	COG2766	serine protein kinase
NRZ33_RS11775	COG2719	SpoVR family
NRZ33_RS11780	COG2186	Transcriptional regulator
NRZ33_RS11785	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NRZ33_RS11790	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NRZ33_RS11795	COG0586	Pfam SNARE associated Golgi protein
NRZ33_RS11805	COG0556	nucleotide-excision repair
NRZ33_RS11815	COG0569	domain protein
NRZ33_RS11815	COG2985	domain, Protein
NRZ33_RS11820	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NRZ33_RS11845	COG3290	protein histidine kinase activity
NRZ33_RS11850	COG1846	Transcriptional regulator
NRZ33_RS11850	COG1940	carbohydrate kinase activity
NRZ33_RS11855	COG0840	transmembrane signaling receptor activity
NRZ33_RS11860	COG3012	SEC-C Motif Domain Protein
NRZ33_RS11865	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NRZ33_RS11870	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
NRZ33_RS11875	COG0247	lactate metabolic process
NRZ33_RS11885	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
NRZ33_RS11890	COG0437	4 iron, 4 sulfur cluster binding
NRZ33_RS11895	COG3301	Polysulphide reductase, NrfD
NRZ33_RS11900	COG1138	Cytochrome C-type biogenesis protein
NRZ33_RS11905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRZ33_RS11910	COG3088	subunit of a heme lyase
NRZ33_RS11910	COG4235	cytochrome complex assembly
NRZ33_RS11915	COG1051	belongs to the nudix hydrolase family
NRZ33_RS11925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRZ33_RS11935	COG1028	Short-chain dehydrogenase reductase Sdr
NRZ33_RS11940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRZ33_RS11945	COG1535	isochorismatase
NRZ33_RS11945	COG3433	isochorismatase activity
NRZ33_RS11950	COG1021	2,3-dihydroxybenzoate-AMP ligase
NRZ33_RS11975	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NRZ33_RS11980	COG3300	MHYT domain
NRZ33_RS11980	COG5001	Diguanylate cyclase
NRZ33_RS11995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRZ33_RS12005	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NRZ33_RS12010	COG0563	adenylate kinase activity
NRZ33_RS12015	COG0326	Molecular chaperone. Has ATPase activity
NRZ33_RS12020	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NRZ33_RS12045	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRZ33_RS12055	COG3158	transport of potassium into the cell
NRZ33_RS12065	COG2223	nitrite transmembrane transporter activity
NRZ33_RS12070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRZ33_RS12080	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NRZ33_RS12085	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRZ33_RS12090	COG0651	ATP synthesis coupled electron transport
NRZ33_RS12095	COG0650	Formate hydrogenlyase subunit 4
NRZ33_RS12100	COG3261	NADH dehydrogenase
NRZ33_RS12100	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
NRZ33_RS12105	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRZ33_RS12110	COG3260	NADH ubiquinone oxidoreductase 20
NRZ33_RS12120	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NRZ33_RS12130	COG1921	L-seryl-tRNASec selenium transferase activity
NRZ33_RS12140	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
NRZ33_RS12145	COG0298	carbon dioxide binding
NRZ33_RS12155	COG0309	Hydrogenase expression formation protein (HypE)
NRZ33_RS12160	COG0375	protein maturation
NRZ33_RS12170	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NRZ33_RS12175	COG1124	(ABC) transporter
NRZ33_RS12180	COG0444	Belongs to the ABC transporter superfamily
NRZ33_RS12185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRZ33_RS12190	COG0601	transmembrane transport
NRZ33_RS12200	COG1773	rubredoxin
NRZ33_RS12205	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NRZ33_RS12210	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
NRZ33_RS12215	COG5557	Pfam Polysulphide reductase, NrfD
NRZ33_RS12220	COG0437	4 iron, 4 sulfur cluster binding
NRZ33_RS12225	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
NRZ33_RS12230	COG0745	RESPONSE REGULATOR receiver
NRZ33_RS12240	COG0643	Histidine kinase
NRZ33_RS12240	COG2198	Histidine kinase
NRZ33_RS12245	COG0840	transmembrane signaling receptor activity
NRZ33_RS12250	COG0835	chemotaxis
NRZ33_RS12260	COG2201	protein-glutamate methylesterase activity
NRZ33_RS12270	COG0840	transmembrane signaling receptor activity
NRZ33_RS12275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NRZ33_RS12290	COG0659	secondary active sulfate transmembrane transporter activity
NRZ33_RS12320	COG0672	)-iron permease
NRZ33_RS12340	COG2814	Major facilitator Superfamily
NRZ33_RS12350	COG1136	(ABC) transporter
NRZ33_RS12355	COG0577	efflux transmembrane transporter activity
NRZ33_RS12385	COG1139	Iron-sulfur cluster binding protein
NRZ33_RS12390	COG0247	lactate metabolic process
NRZ33_RS12395	COG1620	l-lactate permease
NRZ33_RS12400	COG0583	DNA-binding transcription factor activity
NRZ33_RS12410	COG0346	lactoylglutathione lyase activity
NRZ33_RS12415	COG0596	Alpha beta hydrolase
NRZ33_RS12435	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NRZ33_RS12440	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NRZ33_RS12440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NRZ33_RS12445	COG0527	aspartate kinase activity
NRZ33_RS12455	COG1368	sulfuric ester hydrolase activity
NRZ33_RS12460	COG1619	proteins homologs of microcin C7 resistance protein MccF
NRZ33_RS12465	COG4667	esterase of the alpha-beta hydrolase superfamily
NRZ33_RS12475	COG0393	Putative heavy-metal-binding
NRZ33_RS12495	COG1252	NADH dehydrogenase
NRZ33_RS12500	COG3150	esterase
NRZ33_RS12505	COG2233	PERMEase
NRZ33_RS12520	COG2354	Protein conserved in bacteria
NRZ33_RS12530	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRZ33_RS12535	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRZ33_RS12570	COG0537	adenosine 5'-monophosphoramidase activity
NRZ33_RS12585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NRZ33_RS12600	COG1301	dicarboxylic acid transport
NRZ33_RS12610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NRZ33_RS12615	COG0861	Integral membrane protein TerC family
NRZ33_RS12635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRZ33_RS12640	COG0601	transmembrane transport
NRZ33_RS12650	COG2095	MarC family integral membrane protein
NRZ33_RS12660	COG1012	belongs to the aldehyde dehydrogenase family
NRZ33_RS12660	COG1454	alcohol dehydrogenase
NRZ33_RS12665	COG2199	diguanylate cyclase activity
NRZ33_RS12665	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NRZ33_RS12670	COG3275	phosphorelay sensor kinase activity
NRZ33_RS12675	COG3279	Response regulator of the LytR AlgR family
NRZ33_RS12680	COG1966	Carbon starvation protein
NRZ33_RS12690	COG1566	PFAM secretion protein HlyD family protein
NRZ33_RS12695	COG1061	Type III restriction enzyme res subunit
NRZ33_RS12700	COG2027	D-alanyl-D-alanine carboxypeptidase
NRZ33_RS12705	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NRZ33_RS12715	COG0436	Aminotransferase
NRZ33_RS12720	COG1288	antiporter activity
NRZ33_RS12725	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NRZ33_RS12745	COG0697	spore germination
NRZ33_RS12750	COG4657	Part of a membrane complex involved in electron transport
NRZ33_RS12755	COG2878	Part of a membrane complex involved in electron transport
NRZ33_RS12765	COG4658	electron transport chain
NRZ33_RS12770	COG4659	FMN binding
NRZ33_RS12775	COG4660	Part of a membrane complex involved in electron transport
NRZ33_RS12780	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NRZ33_RS12785	COG0346	lactoylglutathione lyase activity
NRZ33_RS12800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NRZ33_RS12805	COG2056	Na+-H+ antiporter family
NRZ33_RS12815	COG2050	protein possibly involved in aromatic compounds catabolism
NRZ33_RS12825	COG0247	lactate metabolic process
NRZ33_RS12825	COG0277	FAD linked oxidase domain protein
NRZ33_RS12835	COG1253	flavin adenine dinucleotide binding
NRZ33_RS12840	COG1902	pentaerythritol trinitrate reductase activity
NRZ33_RS12850	COG0647	UMP catabolic process
NRZ33_RS12855	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NRZ33_RS12855	COG4651	solute:proton antiporter activity
NRZ33_RS12865	COG0367	asparagine synthase
NRZ33_RS12875	COG0625	glutathione transferase activity
NRZ33_RS12885	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NRZ33_RS12900	COG0564	pseudouridine synthase activity
NRZ33_RS12905	COG5001	Diguanylate cyclase
NRZ33_RS12910	COG0840	transmembrane signaling receptor activity
NRZ33_RS12920	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NRZ33_RS12920	COG0392	lysyltransferase activity
NRZ33_RS12925	COG2194	sulfuric ester hydrolase activity
NRZ33_RS12940	COG0670	Belongs to the BI1 family
NRZ33_RS12945	COG1289	transmembrane transporter activity
NRZ33_RS12950	COG2920	part of a sulfur-relay system
NRZ33_RS12955	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
NRZ33_RS12960	COG0285	dihydrofolate synthase activity
NRZ33_RS12965	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NRZ33_RS12970	COG0101	tRNA pseudouridine synthase activity
NRZ33_RS12980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NRZ33_RS12985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NRZ33_RS12990	COG0671	phosphoesterase, PA-phosphatase related
NRZ33_RS12995	COG1464	Belongs to the NlpA lipoprotein family
NRZ33_RS13025	COG0574	Belongs to the PEP-utilizing enzyme family
NRZ33_RS13025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NRZ33_RS13030	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NRZ33_RS13090	COG1242	4 iron, 4 sulfur cluster binding
NRZ33_RS13095	COG0067	glutamate synthase
NRZ33_RS13095	COG0069	glutamate synthase activity
NRZ33_RS13095	COG0070	glutamate synthase
NRZ33_RS13100	COG0493	'glutamate synthase
NRZ33_RS13105	COG1126	abc transporter atp-binding protein
NRZ33_RS13110	COG0765	amino acid transport
NRZ33_RS13115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ33_RS13130	COG0789	Transcriptional regulator
NRZ33_RS13145	COG4104	PAAR repeat-containing protein
NRZ33_RS13155	COG0513	Belongs to the DEAD box helicase family
NRZ33_RS13160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRZ33_RS13195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NRZ33_RS13200	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NRZ33_RS13205	COG0505	Belongs to the CarA family
NRZ33_RS13210	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NRZ33_RS13220	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NRZ33_RS13225	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NRZ33_RS13230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NRZ33_RS13235	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NRZ33_RS13240	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NRZ33_RS13245	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
NRZ33_RS13250	COG4139	cobalamin transport
NRZ33_RS13255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ33_RS13255	COG2205	protein histidine kinase activity
NRZ33_RS13270	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NRZ33_RS13295	COG0023	Translation Initiation Factor
NRZ33_RS13300	COG2119	membrane
NRZ33_RS13330	COG2199	diguanylate cyclase activity
NRZ33_RS13330	COG2203	Gaf domain
NRZ33_RS13355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NRZ33_RS13365	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NRZ33_RS13370	COG3301	Polysulphide reductase, NrfD
NRZ33_RS13375	COG0437	4 iron, 4 sulfur cluster binding
NRZ33_RS13380	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
NRZ33_RS13435	COG0322	excinuclease ABC activity
NRZ33_RS13440	COG2197	response regulator
NRZ33_RS13445	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NRZ33_RS13450	COG2835	tetraacyldisaccharide 4'-kinase activity
NRZ33_RS13455	COG1663	tetraacyldisaccharide 4'-kinase activity
NRZ33_RS13460	COG1132	(ABC) transporter
NRZ33_RS13465	COG0658	competence protein
NRZ33_RS13465	COG2333	competence protein COMEC
NRZ33_RS13480	COG0433	COG0433 Predicted ATPase
NRZ33_RS13485	COG1448	Aminotransferase
NRZ33_RS13500	COG1199	ATP-dependent helicase activity
NRZ33_RS13510	COG0123	including yeast histone deacetylase and acetoin utilization protein
NRZ33_RS13515	COG0477	Major facilitator Superfamily
NRZ33_RS13520	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NRZ33_RS13545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NRZ33_RS13560	COG2271	Major facilitator Superfamily
NRZ33_RS13570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ33_RS13575	COG0765	amino acid transport
NRZ33_RS13580	COG1126	abc transporter atp-binding protein
NRZ33_RS13600	COG0531	amino acid
NRZ33_RS13615	COG1253	flavin adenine dinucleotide binding
NRZ33_RS13620	COG0704	Plays a role in the regulation of phosphate uptake
NRZ33_RS13625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NRZ33_RS13630	COG0581	inorganic phosphate transmembrane transporter activity
NRZ33_RS13635	COG0573	inorganic phosphate transmembrane transporter activity
NRZ33_RS13640	COG0590	tRNA wobble adenosine to inosine editing
NRZ33_RS13655	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NRZ33_RS13675	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NRZ33_RS13680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NRZ33_RS13685	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NRZ33_RS13690	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NRZ33_RS13715	COG2716	regulation of RNA biosynthetic process
NRZ33_RS13720	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NRZ33_RS13730	COG2239	Acts as a magnesium transporter
NRZ33_RS13740	COG1256	bacterial-type flagellum assembly
NRZ33_RS13745	COG1705	Flagellar rod assembly protein muramidase FlgJ
NRZ33_RS13745	COG3951	Flagellar rod assembly protein muramidase FlgJ
NRZ33_RS13750	COG1706	bacterial-type flagellum-dependent cell motility
NRZ33_RS13755	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NRZ33_RS13765	COG4787	bacterial-type flagellum-dependent cell motility
NRZ33_RS13785	COG1815	bacterial-type flagellum-dependent cell motility
NRZ33_RS13790	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NRZ33_RS13795	COG0835	chemotaxis
NRZ33_RS13795	COG0784	Response regulator, receiver
NRZ33_RS13800	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
NRZ33_RS13815	COG0622	Phosphoesterase
NRZ33_RS13845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NRZ33_RS13850	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NRZ33_RS13855	COG1882	Formate acetyltransferase
NRZ33_RS13860	COG1349	DNA-binding transcription factor activity
NRZ33_RS13865	COG0697	spore germination
NRZ33_RS13895	COG1278	Cold shock
NRZ33_RS13935	COG3132	Protein of unknown function, DUF480
NRZ33_RS13945	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NRZ33_RS13965	COG3206	protein involved in exopolysaccharide biosynthesis
NRZ33_RS13965	COG0489	protein tyrosine kinase activity
NRZ33_RS13970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NRZ33_RS13995	COG1216	Glycosyl transferase, family 2
NRZ33_RS14035	COG2194	sulfuric ester hydrolase activity
NRZ33_RS14040	COG0217	transcriptional regulatory protein
NRZ33_RS14045	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NRZ33_RS14050	COG1801	Protein of unknown function DUF72
NRZ33_RS14055	COG4106	trans-aconitate 2-methyltransferase activity
NRZ33_RS14060	COG0500	methyltransferase
NRZ33_RS14080	COG0450	alkyl hydroperoxide reductase
NRZ33_RS14085	COG0583	DNA-binding transcription factor activity
NRZ33_RS14095	COG0791	NLP P60 protein
NRZ33_RS14110	COG1309	transcriptional regulator
NRZ33_RS14150	COG0534	Mate efflux family protein
NRZ33_RS14175	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NRZ33_RS14175	COG0674	pyruvate-flavodoxin oxidoreductase activity
NRZ33_RS14175	COG1013	pyruvate-flavodoxin oxidoreductase activity
NRZ33_RS14175	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NRZ33_RS14185	COG3217	Mosc domain protein beta barrel domain protein
NRZ33_RS14185	COG0633	Ferredoxin
NRZ33_RS14185	COG3217	Mosc domain protein beta barrel domain protein
NRZ33_RS14185	COG0633	Ferredoxin
NRZ33_RS14195	COG0501	Belongs to the peptidase M48B family
NRZ33_RS14200	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NRZ33_RS14205	COG1073	alpha beta
NRZ33_RS14205	COG2226	methyltransferase
NRZ33_RS14210	COG0156	8-amino-7-oxononanoate synthase activity
NRZ33_RS14215	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NRZ33_RS14235	COG0017	Asparaginyl-tRNA synthetase
NRZ33_RS14240	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NRZ33_RS14250	COG1473	amidohydrolase
NRZ33_RS14255	COG3069	C4-dicarboxylate transmembrane transporter activity
NRZ33_RS14265	COG0583	DNA-binding transcription factor activity
NRZ33_RS14270	COG1393	Belongs to the ArsC family
NRZ33_RS14275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NRZ33_RS14280	COG1876	peptidase activity
NRZ33_RS14290	COG3263	regulation of cellular component size
NRZ33_RS14310	COG1280	lysine exporter protein (LysE YggA)
NRZ33_RS14340	COG0564	pseudouridine synthase activity
NRZ33_RS14350	COG1454	alcohol dehydrogenase
NRZ33_RS14400	COG4964	Belongs to the GSP D family
NRZ33_RS14430	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NRZ33_RS14435	COG0702	epimerase
NRZ33_RS14440	COG2914	Belongs to the UPF0125 (RnfH) family
NRZ33_RS14445	COG2867	negative regulation of translational initiation
NRZ33_RS14450	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NRZ33_RS14470	COG0732	type I restriction modification DNA specificity domain
NRZ33_RS14500	COG0583	DNA-binding transcription factor activity
NRZ33_RS14505	COG2610	gluconate transmembrane transporter activity
NRZ33_RS14510	COG3048	D-serine ammonia-lyase activity
NRZ33_RS14520	COG0538	isocitrate dehydrogenase activity
NRZ33_RS14525	COG2207	Transcriptional regulator
NRZ33_RS14545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRZ33_RS14560	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NRZ33_RS14565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRZ33_RS14565	COG1263	PTS System
NRZ33_RS14570	COG1609	Transcriptional regulator
NRZ33_RS14600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRZ33_RS14600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRZ33_RS14600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ33_RS14605	COG5599	Phosphatase
NRZ33_RS14620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRZ33_RS14620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRZ33_RS14620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ33_RS14630	COG1187	pseudouridine synthase activity
NRZ33_RS14640	COG0482	sulfurtransferase activity
NRZ33_RS14645	COG2915	High frequency lysogenization protein hflD homolog
NRZ33_RS14650	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NRZ33_RS14655	COG2850	peptidyl-arginine hydroxylation
NRZ33_RS14660	COG3153	acetyltransferase
NRZ33_RS14670	COG0625	glutathione transferase activity
NRZ33_RS14675	COG0259	pyridoxamine-phosphate oxidase activity
NRZ33_RS14690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NRZ33_RS14690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NRZ33_RS14695	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NRZ33_RS14710	COG3088	subunit of a heme lyase
NRZ33_RS14710	COG4235	cytochrome complex assembly
NRZ33_RS14715	COG3088	subunit of a heme lyase
NRZ33_RS14715	COG4235	cytochrome complex assembly
NRZ33_RS14720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRZ33_RS14725	COG1138	Cytochrome C-type biogenesis protein
NRZ33_RS14730	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NRZ33_RS14735	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NRZ33_RS14740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NRZ33_RS14745	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NRZ33_RS14760	COG0835	chemotaxis
NRZ33_RS14770	COG1192	Involved in chromosome partitioning
NRZ33_RS14775	COG1360	Flagellar Motor Protein
NRZ33_RS14780	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NRZ33_RS14785	COG2201	protein-glutamate methylesterase activity
NRZ33_RS14790	COG2198	Histidine kinase
NRZ33_RS14790	COG0784	Response regulator, receiver
NRZ33_RS14790	COG0643	Histidine kinase
NRZ33_RS14795	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
NRZ33_RS14820	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NRZ33_RS14830	COG1684	flagellar biosynthetic protein fliR
NRZ33_RS14885	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NRZ33_RS14895	COG1677	Flagellar hook-basal body complex protein FliE
NRZ33_RS14910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NRZ33_RS14920	COG1073	alpha beta
NRZ33_RS14920	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
NRZ33_RS14920	COG3064	Membrane
NRZ33_RS14925	COG2994	toxin metabolic process
NRZ33_RS14935	COG2274	protein secretion by the type I secretion system
NRZ33_RS14945	COG2274	protein secretion by the type I secretion system
NRZ33_RS14965	COG1737	Transcriptional regulator
NRZ33_RS14970	COG0469	pyruvate kinase activity
NRZ33_RS14985	COG1960	acyl-CoA dehydrogenase activity
NRZ33_RS14995	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NRZ33_RS15005	COG0243	molybdopterin cofactor binding
NRZ33_RS15010	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NRZ33_RS15015	COG0583	DNA-binding transcription factor activity
NRZ33_RS15050	COG1454	alcohol dehydrogenase
NRZ33_RS15050	COG1012	belongs to the aldehyde dehydrogenase family
NRZ33_RS15060	COG1454	alcohol dehydrogenase
NRZ33_RS15060	COG1012	belongs to the aldehyde dehydrogenase family
NRZ33_RS15065	COG1882	Formate acetyltransferase
NRZ33_RS15070	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NRZ33_RS15080	COG4869	propanediol catabolic process
NRZ33_RS15100	COG5002	protein histidine kinase activity
NRZ33_RS15105	COG0745	RESPONSE REGULATOR receiver
NRZ33_RS15110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRZ33_RS15115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRZ33_RS15125	COG1376	ErfK ybiS ycfS ynhG family protein
NRZ33_RS15125	COG1388	LysM domain
NRZ33_RS15140	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
NRZ33_RS15145	COG0791	NLP P60 protein
NRZ33_RS15155	COG3118	belongs to the thioredoxin family
NRZ33_RS15165	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NRZ33_RS15170	COG0788	formyltetrahydrofolate deformylase activity
NRZ33_RS15180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NRZ33_RS15200	COG0366	Alpha amylase catalytic
NRZ33_RS15205	COG0739	heme binding
NRZ33_RS15205	COG0741	lytic transglycosylase activity
NRZ33_RS15205	COG1196	nuclear chromosome segregation
NRZ33_RS15210	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NRZ33_RS15215	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NRZ33_RS15220	COG0673	inositol 2-dehydrogenase activity
NRZ33_RS15240	COG3152	Membrane
NRZ33_RS15280	COG1028	Short-chain dehydrogenase reductase Sdr
NRZ33_RS15285	COG1280	lysine exporter protein (LysE YggA)
NRZ33_RS15295	COG1032	radical SAM domain protein
NRZ33_RS15305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRZ33_RS15310	COG1566	PFAM secretion protein HlyD family protein
NRZ33_RS15320	COG1752	Esterase of the alpha-beta hydrolase superfamily
NRZ33_RS15325	COG0733	neurotransmitter:sodium symporter activity
NRZ33_RS15355	COG0281	malic enzyme
NRZ33_RS15365	COG0534	Mate efflux family protein
NRZ33_RS15380	COG2233	PERMEase
NRZ33_RS15385	COG0095	Lipoate-protein ligase
NRZ33_RS15390	COG1115	amino acid carrier protein
NRZ33_RS15395	COG0019	diaminopimelate decarboxylase activity
NRZ33_RS15405	COG0678	peroxiredoxin activity
NRZ33_RS15415	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NRZ33_RS15435	COG1131	(ABC) transporter
NRZ33_RS15440	COG0545	Peptidyl-prolyl cis-trans isomerase
NRZ33_RS15470	COG5002	protein histidine kinase activity
NRZ33_RS15475	COG0745	RESPONSE REGULATOR receiver
NRZ33_RS15480	COG0346	lactoylglutathione lyase activity
NRZ33_RS15485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NRZ33_RS15490	COG1960	acyl-CoA dehydrogenase activity
NRZ33_RS15495	COG3284	Transcriptional regulator
NRZ33_RS15510	COG0697	spore germination
NRZ33_RS15515	COG4565	transcriptional regulatory protein
NRZ33_RS15520	COG3290	protein histidine kinase activity
NRZ33_RS15525	COG0281	malic enzyme
NRZ33_RS15540	COG1846	Transcriptional regulator
NRZ33_RS15545	COG1566	PFAM secretion protein HlyD family protein
NRZ33_RS15575	COG0602	queuosine metabolic process
NRZ33_RS15580	COG1328	CTP reductase activity
NRZ33_RS15590	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NRZ33_RS15595	COG3115	cell septum assembly
NRZ33_RS15600	COG1196	nuclear chromosome segregation
NRZ33_RS15610	COG2860	membrane
NRZ33_RS15620	COG3108	Peptidase M15
NRZ33_RS15625	COG2989	Protein conserved in bacteria
NRZ33_RS15640	COG0463	Glycosyl transferase, family 2
NRZ33_RS15655	COG0366	Alpha amylase catalytic
NRZ33_RS15695	COG3706	GGDEF domain
NRZ33_RS15705	COG3590	peptidase
NRZ33_RS15715	COG0488	(ABC) transporter
NRZ33_RS15725	COG0531	amino acid
NRZ33_RS15730	COG0814	amino acid
NRZ33_RS15745	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
NRZ33_RS15750	COG1982	Orn Lys Arg decarboxylase major
NRZ33_RS15755	COG0531	amino acid
NRZ33_RS15760	COG3710	Transcriptional regulator
NRZ33_RS15765	COG0825	malonyl-CoA metabolic process
NRZ33_RS15775	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NRZ33_RS15780	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NRZ33_RS15785	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NRZ33_RS15790	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NRZ33_RS15795	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NRZ33_RS15810	COG0750	zinc metalloprotease
NRZ33_RS15815	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NRZ33_RS15820	COG0575	Belongs to the CDS family
NRZ33_RS15825	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NRZ33_RS15830	COG0233	cytoplasmic translational termination
NRZ33_RS15835	COG0528	UMP kinase activity
NRZ33_RS15840	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NRZ33_RS15845	COG0052	Belongs to the universal ribosomal protein uS2 family
NRZ33_RS15850	COG0024	Methionine aminopeptidase
NRZ33_RS15855	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NRZ33_RS15860	COG2171	N-acyltransferase activity
NRZ33_RS15870	COG1263	PTS System
NRZ33_RS15870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRZ33_RS15880	COG4580	involved in the transport of maltose and maltodextrins
NRZ33_RS15890	COG0564	pseudouridine synthase activity
NRZ33_RS15895	COG3098	single-species biofilm formation
NRZ33_RS15920	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
NRZ33_RS15930	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NRZ33_RS15930	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NRZ33_RS15945	COG1611	Belongs to the LOG family
NRZ33_RS15950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NRZ33_RS15955	COG0473	3-isopropylmalate dehydrogenase activity
NRZ33_RS15965	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
NRZ33_RS15970	COG2363	Small membrane protein
NRZ33_RS15980	COG0583	DNA-binding transcription factor activity
NRZ33_RS15985	COG0840	transmembrane signaling receptor activity
NRZ33_RS15990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NRZ33_RS16005	COG1477	protein flavinylation
NRZ33_RS16010	COG2871	sodium ion transport
NRZ33_RS16015	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NRZ33_RS16020	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NRZ33_RS16025	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NRZ33_RS16030	COG1805	sodium ion transport
NRZ33_RS16035	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NRZ33_RS16040	COG0271	Belongs to the BolA IbaG family
NRZ33_RS16045	COG2813	Specifically methylates the guanine in position
NRZ33_RS16055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NRZ33_RS16065	COG2211	Major facilitator Superfamily
NRZ33_RS16070	COG3248	Nucleoside-binding outer membrane protein
NRZ33_RS16075	COG1666	GTP binding
NRZ33_RS16080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NRZ33_RS16085	COG0693	protein deglycase activity
NRZ33_RS16150	COG2771	luxR family
NRZ33_RS16160	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NRZ33_RS16160	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NRZ33_RS16165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NRZ33_RS16175	COG1151	hydroxylamine reductase activity
NRZ33_RS16180	COG0783	Belongs to the Dps family
NRZ33_RS16205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NRZ33_RS16220	COG4221	oxidoreductase activity
NRZ33_RS16230	COG0415	Belongs to the DNA photolyase family
NRZ33_RS16235	COG0789	Transcriptional regulator
NRZ33_RS16240	COG3272	Protein of unknown function (DUF1722)
NRZ33_RS16270	COG0077	Prephenate dehydratase
NRZ33_RS16270	COG1605	Chorismate mutase
NRZ33_RS16300	COG5377	YqaJ viral recombinase family
NRZ33_RS16345	COG2003	Belongs to the UPF0758 family
NRZ33_RS16385	COG1715	Restriction endonuclease
NRZ33_RS16410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NRZ33_RS16440	COG1349	DNA-binding transcription factor activity
NRZ33_RS16445	COG2084	Dehydrogenase
NRZ33_RS16455	COG0235	Class ii aldolase
NRZ33_RS16460	COG3622	Belongs to the hyi family
NRZ33_RS16465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRZ33_RS16470	COG2610	gluconate transmembrane transporter activity
NRZ33_RS16480	COG0840	transmembrane signaling receptor activity
NRZ33_RS16490	COG0300	oxidoreductase activity
NRZ33_RS16515	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NRZ33_RS16530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NRZ33_RS16535	COG0826	peptidase U32
NRZ33_RS16540	COG1280	lysine exporter protein (LysE YggA)
NRZ33_RS16550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NRZ33_RS16555	COG0840	transmembrane signaling receptor activity
NRZ33_RS16570	COG0643	Histidine kinase
NRZ33_RS16570	COG2198	Histidine kinase
NRZ33_RS16580	COG0835	chemotaxis
NRZ33_RS16585	COG0840	transmembrane signaling receptor activity
NRZ33_RS16595	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
NRZ33_RS16600	COG2201	protein-glutamate methylesterase activity
NRZ33_RS16605	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NRZ33_RS16630	COG2205	protein histidine kinase activity
NRZ33_RS16630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ33_RS16635	COG2197	response regulator
NRZ33_RS16645	COG3188	usher protein
NRZ33_RS16660	COG2203	Gaf domain
NRZ33_RS16660	COG2199	diguanylate cyclase activity
NRZ33_RS16660	COG2200	EAL domain
NRZ33_RS16665	COG0826	peptidase U32
NRZ33_RS16670	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NRZ33_RS16680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NRZ33_RS16695	COG2200	EAL domain
NRZ33_RS16700	COG0737	Belongs to the 5'-nucleotidase family
NRZ33_RS16720	COG2204	response regulator
NRZ33_RS16725	COG0545	Peptidyl-prolyl cis-trans isomerase
NRZ33_RS16740	COG1047	Peptidyl-prolyl cis-trans
NRZ33_RS16745	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
NRZ33_RS16755	COG0784	Response regulator, receiver
NRZ33_RS16755	COG0835	chemotaxis
NRZ33_RS16760	COG0429	hydrolase of the alpha beta-hydrolase fold
NRZ33_RS16765	COG5001	Diguanylate cyclase
NRZ33_RS16765	COG4251	negative regulation of phosphorylation
NRZ33_RS16765	COG3706	GGDEF domain
NRZ33_RS16765	COG2203	Gaf domain
NRZ33_RS16770	COG3089	Belongs to the UPF0270 family
NRZ33_RS16780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NRZ33_RS16785	COG0463	Glycosyl transferase, family 2
NRZ33_RS16790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRZ33_RS16790	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NRZ33_RS16795	COG0726	polysaccharide deacetylase
NRZ33_RS16800	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NRZ33_RS16805	COG2076	Multidrug Resistance protein
NRZ33_RS16810	COG2076	Multidrug Resistance protein
NRZ33_RS16815	COG3954	Phosphoribulokinase
NRZ33_RS16830	COG1765	OsmC-like protein
NRZ33_RS16840	COG2226	methyltransferase
NRZ33_RS16845	COG3397	chitin binding
NRZ33_RS16860	COG2205	protein histidine kinase activity
NRZ33_RS16860	COG2202	Pas domain
NRZ33_RS16870	COG3655	Transcriptional regulator
NRZ33_RS16875	COG2814	Major facilitator Superfamily
NRZ33_RS16880	COG4771	TonB-dependent receptor
NRZ33_RS16900	COG0748	coenzyme F420 binding
NRZ33_RS16905	COG3721	Heme iron utilization protein
NRZ33_RS16915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRZ33_RS16940	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NRZ33_RS16945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRZ33_RS16950	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NRZ33_RS16970	COG0741	lytic transglycosylase activity
NRZ33_RS16975	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NRZ33_RS16990	COG0488	(ABC) transporter
NRZ33_RS17000	COG2252	PERMEase
NRZ33_RS17005	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NRZ33_RS17010	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NRZ33_RS17015	COG3178	'Phosphotransferase
NRZ33_RS17020	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NRZ33_RS17030	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NRZ33_RS17035	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NRZ33_RS17040	COG2967	ApaG domain
NRZ33_RS17045	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NRZ33_RS17055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NRZ33_RS17060	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NRZ33_RS17075	COG0318	PFAM AMP-dependent synthetase and ligase
NRZ33_RS17080	COG3314	Sporulation integral membrane protein YlbJ
NRZ33_RS17085	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NRZ33_RS17090	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NRZ33_RS17095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NRZ33_RS17100	COG0142	geranyltranstransferase activity
NRZ33_RS17105	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
NRZ33_RS17110	COG0330	HflC and HflK could
NRZ33_RS17115	COG0330	HflC and HflK could
NRZ33_RS17120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NRZ33_RS17125	COG1923	regulation of RNA biosynthetic process
NRZ33_RS17130	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NRZ33_RS17135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NRZ33_RS17145	COG0802	atpase or kinase
NRZ33_RS17150	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NRZ33_RS17150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NRZ33_RS17155	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NRZ33_RS17170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NRZ33_RS17175	COG2011	ABC-type metal ion transport system permease component
NRZ33_RS17180	COG1464	Belongs to the NlpA lipoprotein family
NRZ33_RS17200	COG0840	transmembrane signaling receptor activity
NRZ33_RS17225	COG0784	Response regulator, receiver
NRZ33_RS17225	COG2198	Histidine kinase
NRZ33_RS17225	COG5002	protein histidine kinase activity
NRZ33_RS17245	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
NRZ33_RS17260	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NRZ33_RS17265	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
NRZ33_RS17275	COG2716	regulation of RNA biosynthetic process
NRZ33_RS17280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NRZ33_RS17285	COG3013	Belongs to the UPF0304 family
NRZ33_RS17295	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NRZ33_RS17300	COG0280	phosphate acetyltransferase
NRZ33_RS17300	COG0857	belongs to the CobB CobQ family
NRZ33_RS17310	COG0028	Belongs to the TPP enzyme family
NRZ33_RS17320	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NRZ33_RS17325	COG0671	phosphoesterase, PA-phosphatase related
NRZ33_RS17335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NRZ33_RS17340	COG0473	3-isopropylmalate dehydrogenase activity
NRZ33_RS17345	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NRZ33_RS17350	COG0066	3-isopropylmalate dehydratase activity
NRZ33_RS17365	COG4143	(ABC) transporter
NRZ33_RS17375	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
NRZ33_RS17380	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NRZ33_RS17390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NRZ33_RS17420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NRZ33_RS17425	COG0564	pseudouridine synthase activity
NRZ33_RS17435	COG5001	Diguanylate cyclase
NRZ33_RS17435	COG3300	MHYT domain
NRZ33_RS17445	COG0459	protein refolding
NRZ33_RS17450	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NRZ33_RS17455	COG0534	Mate efflux family protein
NRZ33_RS17460	COG3030	protein affecting phage T7 exclusion by the F plasmid
NRZ33_RS17465	COG1027	Aspartate ammonia-lyase
NRZ33_RS17470	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NRZ33_RS17480	COG0477	Major facilitator Superfamily
NRZ33_RS17495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRZ33_RS17500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRZ33_RS17510	COG0673	inositol 2-dehydrogenase activity
NRZ33_RS17520	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NRZ33_RS17525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NRZ33_RS17530	COG3036	rescue of stalled ribosome
NRZ33_RS17535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NRZ33_RS17545	COG0138	bifunctional purine biosynthesis protein purh
NRZ33_RS17550	COG0151	Belongs to the GarS family
NRZ33_RS17575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NRZ33_RS17580	COG0358	DNA primase activity
NRZ33_RS17585	COG1610	YqeY-like protein
NRZ33_RS17590	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NRZ33_RS17595	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NRZ33_RS17610	COG1238	metal cluster binding
NRZ33_RS17615	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NRZ33_RS17620	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NRZ33_RS17625	COG0585	pseudouridine synthase activity
NRZ33_RS17635	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NRZ33_RS17640	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NRZ33_RS17645	COG0148	phosphopyruvate hydratase activity
NRZ33_RS17650	COG0504	CTP synthase activity
NRZ33_RS17655	COG3956	TIGRFAM MazG family protein
NRZ33_RS17660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NRZ33_RS17665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NRZ33_RS17675	COG4807	Protein conserved in bacteria
NRZ33_RS17680	COG3023	N-Acetylmuramoyl-L-alanine amidase
NRZ33_RS17685	COG1349	DNA-binding transcription factor activity
NRZ33_RS17695	COG2222	sugar isomerase
NRZ33_RS17700	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRZ33_RS17710	COG3716	PTS system mannose fructose sorbose family IID component
NRZ33_RS17715	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ33_RS17720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NRZ33_RS17735	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NRZ33_RS17740	COG1381	Involved in DNA repair and RecF pathway recombination
NRZ33_RS17750	COG0571	ribonuclease III activity
NRZ33_RS17755	COG0681	Belongs to the peptidase S26 family
NRZ33_RS17760	COG0481	GTPase activity
NRZ33_RS17775	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
NRZ33_RS17780	COG1595	DNA-templated transcription, initiation
NRZ33_RS17785	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NRZ33_RS17795	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NRZ33_RS17800	COG0354	folic acid binding
NRZ33_RS17825	COG4232	protein-disulfide reductase activity
NRZ33_RS17840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRZ33_RS17850	COG0126	phosphoglycerate kinase activity
NRZ33_RS17855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NRZ33_RS17860	COG1940	carbohydrate kinase activity
NRZ33_RS17865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NRZ33_RS17880	COG4991	sh3 domain protein
NRZ33_RS17885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NRZ33_RS17900	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NRZ33_RS17905	COG1028	Short-chain dehydrogenase reductase Sdr
NRZ33_RS17925	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NRZ33_RS17930	COG0765	amino acid transport
NRZ33_RS17935	COG0765	amino acid transport
NRZ33_RS17940	COG1126	abc transporter atp-binding protein
NRZ33_RS17945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ33_RS17955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRZ33_RS17960	COG0745	RESPONSE REGULATOR receiver
NRZ33_RS17965	COG2205	protein histidine kinase activity
NRZ33_RS17970	COG2816	NAD+ diphosphatase activity
NRZ33_RS18005	COG2070	2-Nitropropane dioxygenase
NRZ33_RS18030	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
NRZ33_RS18050	COG3706	GGDEF domain
NRZ33_RS18055	COG0513	Belongs to the DEAD box helicase family
NRZ33_RS18075	COG0154	amidase activity
NRZ33_RS18080	COG2957	Belongs to the agmatine deiminase family
NRZ33_RS18090	COG2852	Protein conserved in bacteria
NRZ33_RS18100	COG1902	pentaerythritol trinitrate reductase activity
NRZ33_RS18135	COG3300	MHYT domain
NRZ33_RS18135	COG5001	Diguanylate cyclase
NRZ33_RS18145	COG0714	Associated with various cellular activities
NRZ33_RS18155	COG0456	acetyltransferase
NRZ33_RS18165	COG1022	Amp-dependent synthetase and ligase
NRZ33_RS18175	COG2918	glutathione biosynthetic process
NRZ33_RS18180	COG0612	Peptidase, M16
NRZ33_RS18185	COG1238	metal cluster binding
NRZ33_RS18210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NRZ33_RS18215	COG0359	binds to the 23S rRNA
NRZ33_RS18220	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NRZ33_RS18225	COG0360	Binds together with S18 to 16S ribosomal RNA
NRZ33_RS18230	COG1914	H( )-stimulated, divalent metal cation uptake system
NRZ33_RS18250	COG2153	protein acetylation
NRZ33_RS18260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NRZ33_RS18280	COG0557	exoribonuclease II activity
NRZ33_RS18285	COG3706	GGDEF domain
NRZ33_RS18290	COG1854	S-ribosylhomocysteine lyase activity
NRZ33_RS18305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NRZ33_RS18305	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NRZ33_RS18345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NRZ33_RS18350	COG1047	Peptidyl-prolyl cis-trans
NRZ33_RS18355	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NRZ33_RS18360	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NRZ33_RS18365	COG0196	riboflavin kinase activity
NRZ33_RS18370	COG0728	peptidoglycan biosynthetic process
NRZ33_RS18375	COG0268	Binds directly to 16S ribosomal RNA
NRZ33_RS18380	COG0640	Transcriptional regulator
NRZ33_RS18385	COG0583	DNA-binding transcription factor activity
NRZ33_RS18395	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NRZ33_RS18400	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NRZ33_RS18405	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NRZ33_RS18410	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
NRZ33_RS18415	COG1051	belongs to the nudix hydrolase family
NRZ33_RS18420	COG3066	DNA modification
NRZ33_RS18430	COG0335	large ribosomal subunit rRNA binding
NRZ33_RS18435	COG0336	Belongs to the RNA methyltransferase TrmD family
NRZ33_RS18440	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NRZ33_RS18445	COG0228	four-way junction DNA binding
NRZ33_RS18450	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NRZ33_RS18455	COG4137	Cytochrome C assembly protein
NRZ33_RS18460	COG4536	flavin adenine dinucleotide binding
NRZ33_RS18470	COG1017	nitric oxide dioxygenase activity
NRZ33_RS18470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NRZ33_RS18475	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
NRZ33_RS18480	COG0039	L-malate dehydrogenase activity
NRZ33_RS18485	COG4160	amino acid transport
NRZ33_RS18490	COG4215	(ABC) transporter
NRZ33_RS18495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ33_RS18500	COG1126	abc transporter atp-binding protein
NRZ33_RS18505	COG1438	arginine binding
NRZ33_RS18510	COG2837	iron assimilation
NRZ33_RS18515	COG3842	ATPase activity
NRZ33_RS18525	COG1840	ABC-type Fe3 transport system, periplasmic component
NRZ33_RS18530	COG0347	Belongs to the P(II) protein family
NRZ33_RS18545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRZ33_RS18550	COG0583	DNA-binding transcription factor activity
NRZ33_RS18565	COG1929	Belongs to the glycerate kinase type-1 family
NRZ33_RS18570	COG2610	gluconate transmembrane transporter activity
NRZ33_RS18575	COG3835	regulator
NRZ33_RS18580	COG3112	Uncharacterised protein family (UPF0231)
NRZ33_RS18595	COG0840	transmembrane signaling receptor activity
NRZ33_RS18615	COG0513	Belongs to the DEAD box helicase family
NRZ33_RS18655	COG1448	Aminotransferase
NRZ33_RS18670	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NRZ33_RS18675	COG1328	CTP reductase activity
NRZ33_RS18695	COG0793	Belongs to the peptidase S41A family
NRZ33_RS18695	COG4946	Tricorn protease homolog
NRZ33_RS18745	COG3397	chitin binding
NRZ33_RS18750	COG0583	DNA-binding transcription factor activity
NRZ33_RS18755	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NRZ33_RS18760	COG4208	sulfate ABC transporter
NRZ33_RS18765	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NRZ33_RS18775	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NRZ33_RS18780	COG3174	membrane
NRZ33_RS18785	COG0110	maltose O-acetyltransferase activity
NRZ33_RS18815	COG0165	Argininosuccinate lyase
NRZ33_RS18820	COG0137	argininosuccinate synthase activity
NRZ33_RS18830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NRZ33_RS18835	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NRZ33_RS18845	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NRZ33_RS18850	COG0527	aspartate kinase activity
NRZ33_RS18850	COG0460	homoserine dehydrogenase
NRZ33_RS18855	COG0626	cystathionine gamma-synthase activity
NRZ33_RS18865	COG2207	Transcriptional regulator
NRZ33_RS18865	COG3708	Transcriptional regulator
NRZ33_RS18870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRZ33_RS18875	COG0814	amino acid
NRZ33_RS18880	COG1218	3'(2'),5'-bisphosphate nucleotidase
NRZ33_RS18885	COG0494	nUDIX hydrolase
NRZ33_RS18890	COG1011	Hydrolase
NRZ33_RS18895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NRZ33_RS18910	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
NRZ33_RS18920	COG3156	type II secretion system protein K
NRZ33_RS18935	COG4795	General secretion pathway protein
NRZ33_RS18940	COG2165	general secretion pathway protein
NRZ33_RS18950	COG2165	general secretion pathway protein
NRZ33_RS18955	COG1459	type II secretion system
NRZ33_RS18960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NRZ33_RS18970	COG3031	protein transport across the cell outer membrane
NRZ33_RS18980	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NRZ33_RS18985	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NRZ33_RS19005	COG0456	acetyltransferase
NRZ33_RS19010	COG3133	Outer membrane lipoprotein
NRZ33_RS19025	COG2771	luxR family
NRZ33_RS19030	COG3916	Acyl-homoserine-lactone synthase
NRZ33_RS19040	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
NRZ33_RS19045	COG1309	transcriptional regulator
NRZ33_RS19055	COG2213	PTS system mannitol-specific
NRZ33_RS19055	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRZ33_RS19060	COG0246	Mannitol dehydrogenase
NRZ33_RS19065	COG3722	fumarate hydratase activity
NRZ33_RS19070	COG3263	regulation of cellular component size
NRZ33_RS19095	COG1671	Belongs to the UPF0178 family
NRZ33_RS19110	COG1988	membrane-bound metal-dependent
NRZ33_RS19115	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRZ33_RS19120	COG0513	Belongs to the DEAD box helicase family
NRZ33_RS19145	COG1575	Belongs to the MenA family. Type 1 subfamily
NRZ33_RS19150	COG1169	isochorismate synthase
NRZ33_RS19155	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NRZ33_RS19160	COG0596	Alpha beta hydrolase
NRZ33_RS19165	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NRZ33_RS19170	COG1441	menaquinone biosynthetic process
NRZ33_RS19175	COG0318	PFAM AMP-dependent synthetase and ligase
NRZ33_RS19195	COG3121	Chaperone
NRZ33_RS19200	COG3188	usher protein
NRZ33_RS19210	COG3539	Fimbrial protein
NRZ33_RS19220	COG3291	Pkd domain containing protein
NRZ33_RS19225	COG2949	membrane
NRZ33_RS19230	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NRZ33_RS19240	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NRZ33_RS19245	COG5380	lipid catabolic process
NRZ33_RS19260	COG4533	DNA binding
NRZ33_RS19270	COG2873	o-acetylhomoserine
NRZ33_RS19280	COG1979	alcohol dehydrogenase
NRZ33_RS19300	COG4221	oxidoreductase activity
NRZ33_RS19320	COG1285	pathogenesis
NRZ33_RS19340	COG1368	sulfuric ester hydrolase activity
NRZ33_RS19345	COG1522	sequence-specific DNA binding
NRZ33_RS19355	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NRZ33_RS19360	COG1418	mRNA catabolic process
NRZ33_RS19365	COG1058	Belongs to the CinA family
NRZ33_RS19365	COG1546	Belongs to the CinA family
NRZ33_RS19375	COG0561	phosphatase activity
NRZ33_RS19380	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NRZ33_RS19400	COG1011	Hydrolase
NRZ33_RS19415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NRZ33_RS19420	COG0019	diaminopimelate decarboxylase activity
NRZ33_RS19430	COG1965	Belongs to the frataxin family
NRZ33_RS19435	COG0400	carboxylic ester hydrolase activity
NRZ33_RS19440	COG3072	Adenylate cyclase
NRZ33_RS19445	COG0181	hydroxymethylbilane synthase activity
NRZ33_RS19455	COG2959	enzyme of heme biosynthesis
NRZ33_RS19470	COG1494	fructose-1,6-bisphosphatase
NRZ33_RS19510	COG1733	regulation of RNA biosynthetic process
NRZ33_RS19530	COG3932	Exopolysaccharide synthesis, ExoD
NRZ33_RS19535	COG0814	amino acid
NRZ33_RS19560	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
NRZ33_RS19565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRZ33_RS19580	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NRZ33_RS19585	COG2022	thiamine diphosphate biosynthetic process
NRZ33_RS19595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NRZ33_RS19600	COG0352	thiamine-phosphate diphosphorylase activity
NRZ33_RS19605	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NRZ33_RS19625	COG0745	RESPONSE REGULATOR receiver
NRZ33_RS19630	COG0642	Histidine kinase
NRZ33_RS19640	COG0189	ligase activity
NRZ33_RS19665	COG1639	'signal transduction protein
NRZ33_RS19675	COG2321	neutral zinc metallopeptidase
NRZ33_RS19680	COG3700	Belongs to the class B bacterial acid phosphatase family
NRZ33_RS19700	COG1366	Belongs to the anti-sigma-factor antagonist family
NRZ33_RS19705	COG2172	sigma factor antagonist activity
NRZ33_RS19710	COG5002	protein histidine kinase activity
NRZ33_RS19710	COG2205	protein histidine kinase activity
NRZ33_RS19710	COG0784	Response regulator, receiver
NRZ33_RS19715	COG3437	response regulator, receiver
NRZ33_RS19725	COG0477	Major facilitator Superfamily
NRZ33_RS19745	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NRZ33_RS19750	COG1263	PTS System
NRZ33_RS19750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRZ33_RS19770	COG0312	modulator of DNA gyrase
NRZ33_RS19775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NRZ33_RS19790	COG3164	Protein of unknown function
NRZ33_RS19795	COG1530	ribonuclease E activity
NRZ33_RS19800	COG0424	maF-like protein
NRZ33_RS19805	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NRZ33_RS19810	COG1792	Involved in formation and maintenance of cell shape
NRZ33_RS19815	COG1077	Cell shape determining protein MreB Mrl
NRZ33_RS19840	COG4968	Prepilin-type N-terminal cleavage methylation domain
NRZ33_RS19845	COG4969	Belongs to the N-Me-Phe pilin family
NRZ33_RS19850	COG2165	general secretion pathway protein
NRZ33_RS19860	COG1459	type II secretion system
NRZ33_RS19865	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NRZ33_RS19910	COG2200	EAL domain
NRZ33_RS19910	COG2199	diguanylate cyclase activity
NRZ33_RS19915	COG2200	EAL domain
NRZ33_RS19920	COG0387	Pfam Sodium calcium exchanger
NRZ33_RS19925	COG2986	histidine ammonia-lyase
NRZ33_RS19930	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NRZ33_RS19935	COG0010	Belongs to the arginase family
NRZ33_RS19940	COG1228	amidohydrolase
NRZ33_RS19945	COG2188	Transcriptional regulator
NRZ33_RS19950	COG0288	reversible hydration of carbon dioxide
NRZ33_RS19960	COG2177	Part of the ABC transporter FtsEX involved in
NRZ33_RS19965	COG2884	Cell division ATP-binding protein ftsE
NRZ33_RS19970	COG0552	protein localization to endoplasmic reticulum
NRZ33_RS19975	COG0742	ribosomal rna small subunit methyltransferase
NRZ33_RS20000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NRZ33_RS20010	COG0741	lytic transglycosylase activity
NRZ33_RS20020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NRZ33_RS20030	COG2095	MarC family integral membrane protein
NRZ33_RS20040	COG1301	dicarboxylic acid transport
NRZ33_RS20065	COG3714	YhhN family
NRZ33_RS20090	COG1770	oligopeptidase
NRZ33_RS20105	COG4221	oxidoreductase activity
NRZ33_RS20110	COG0583	DNA-binding transcription factor activity
NRZ33_RS20115	COG2249	NAD(P)H dehydrogenase (quinone) activity
NRZ33_RS20160	COG0203	ribosomal protein L17
NRZ33_RS20165	COG0202	RNA polymerase activity
NRZ33_RS20170	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NRZ33_RS20175	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NRZ33_RS20180	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NRZ33_RS20185	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NRZ33_RS20190	COG0201	protein transport
NRZ33_RS20195	COG0200	Binds to the 23S rRNA
NRZ33_RS20200	COG1841	ribosomal large subunit assembly
NRZ33_RS20205	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NRZ33_RS20210	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NRZ33_RS20215	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NRZ33_RS20220	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NRZ33_RS20225	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NRZ33_RS20230	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NRZ33_RS20235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NRZ33_RS20240	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NRZ33_RS20245	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NRZ33_RS20250	COG0255	Belongs to the universal ribosomal protein uL29 family
NRZ33_RS20255	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NRZ33_RS20260	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NRZ33_RS20265	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NRZ33_RS20270	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NRZ33_RS20275	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NRZ33_RS20280	COG0089	rRNA binding
NRZ33_RS20285	COG0088	Forms part of the polypeptide exit tunnel
NRZ33_RS20290	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NRZ33_RS20295	COG0051	transcription antitermination factor activity, RNA binding
NRZ33_RS20315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NRZ33_RS20320	COG2183	response to ionizing radiation
NRZ33_RS20340	COG0596	Alpha beta hydrolase
NRZ33_RS20345	COG1040	competence protein
NRZ33_RS20350	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NRZ33_RS20350	COG0316	Belongs to the HesB IscA family
NRZ33_RS20355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NRZ33_RS20360	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
NRZ33_RS20365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NRZ33_RS20370	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NRZ33_RS20375	COG4942	peptidase
NRZ33_RS20385	COG1609	Transcriptional regulator
NRZ33_RS20390	COG0800	Aldolase
NRZ33_RS20395	COG0129	dihydroxy-acid dehydratase activity
NRZ33_RS20400	COG3265	gluconokinase activity
NRZ33_RS20405	COG2610	gluconate transmembrane transporter activity
NRZ33_RS20410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NRZ33_RS20415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NRZ33_RS20425	COG0456	acetyltransferase
NRZ33_RS20435	COG1490	D-aminoacyl-tRNA deacylase activity
NRZ33_RS20445	COG1295	ribonuclease BN
NRZ33_RS20450	COG1217	gtp-binding protein TYPA
NRZ33_RS20455	COG0174	glutamine synthetase
NRZ33_RS20465	COG3852	Histidine kinase
NRZ33_RS20470	COG2204	response regulator
NRZ33_RS20475	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NRZ33_RS20480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NRZ33_RS20490	COG3078	GTPase activator activity
NRZ33_RS20500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NRZ33_RS20510	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NRZ33_RS20515	COG0408	coproporphyrinogen oxidase activity
NRZ33_RS20520	COG0009	L-threonylcarbamoyladenylate synthase
NRZ33_RS20530	COG0551	DNA topoisomerase type I activity
NRZ33_RS20535	COG2922	Belongs to the Smg family
NRZ33_RS20540	COG0758	DNA mediated transformation
NRZ33_RS20550	COG0242	peptide deformylase activity
NRZ33_RS20555	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NRZ33_RS20560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NRZ33_RS20560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NRZ33_RS20565	COG0569	domain protein
NRZ33_RS20570	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NRZ33_RS20575	COG1322	Protein conserved in bacteria
NRZ33_RS20595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRZ33_RS20600	COG0686	Belongs to the AlaDH PNT family
NRZ33_RS20605	COG0519	Catalyzes the synthesis of GMP from XMP
NRZ33_RS20605	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NRZ33_RS20615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NRZ33_RS20620	COG1396	sequence-specific DNA binding
NRZ33_RS20625	COG1012	belongs to the aldehyde dehydrogenase family
NRZ33_RS20635	COG2962	Rard protein
NRZ33_RS20645	COG1280	lysine exporter protein (LysE YggA)
NRZ33_RS20655	COG2391	methyltransferase activity
NRZ33_RS20690	COG3161	chorismate lyase activity
NRZ33_RS20715	COG0583	DNA-binding transcription factor activity
NRZ33_RS20720	COG1943	Transposase
NRZ33_RS20730	COG0210	DNA helicase
NRZ33_RS20735	COG1744	ABC transporter substrate-binding protein PnrA-like
NRZ33_RS20740	COG3845	ABC transporter
NRZ33_RS20745	COG4603	Belongs to the binding-protein-dependent transport system permease family
NRZ33_RS20750	COG1079	Belongs to the binding-protein-dependent transport system permease family
NRZ33_RS20755	COG0583	DNA-binding transcription factor activity
NRZ33_RS20775	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NRZ33_RS20780	COG0385	Bile acid
NRZ33_RS20785	COG0531	amino acid
NRZ33_RS20790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRZ33_RS20795	COG0531	amino acid
NRZ33_RS20800	COG2731	YhcH YjgK YiaL family protein
NRZ33_RS20805	COG3250	beta-galactosidase activity
NRZ33_RS20810	COG1609	Transcriptional regulator
NRZ33_RS20845	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NRZ33_RS20850	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NRZ33_RS20850	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NRZ33_RS20855	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
NRZ33_RS20860	COG3074	FtsZ-dependent cytokinesis
NRZ33_RS20870	COG1045	serine acetyltransferase
NRZ33_RS20880	COG0745	RESPONSE REGULATOR receiver
NRZ33_RS20885	COG2205	protein histidine kinase activity
NRZ33_RS20890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NRZ33_RS20895	COG0534	Mate efflux family protein
NRZ33_RS20910	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NRZ33_RS20915	COG2937	Belongs to the GPAT DAPAT family
NRZ33_RS20920	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NRZ33_RS20925	COG3161	chorismate lyase activity
NRZ33_RS20930	COG1580	Controls the rotational direction of flagella during chemotaxis
NRZ33_RS20950	COG0604	alcohol dehydrogenase
NRZ33_RS20955	COG1609	Transcriptional regulator
NRZ33_RS20975	COG1519	Transferase
NRZ33_RS20980	COG0859	PFAM glycosyl transferase family 9
NRZ33_RS20985	COG0463	Glycosyl transferase, family 2
NRZ33_RS20990	COG0859	PFAM glycosyl transferase family 9
NRZ33_RS20995	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NRZ33_RS21000	COG2990	Protein conserved in bacteria
NRZ33_RS21005	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NRZ33_RS21015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NRZ33_RS21020	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NRZ33_RS21025	COG2003	Belongs to the UPF0758 family
NRZ33_RS21030	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NRZ33_RS21035	COG0756	dUTP diphosphatase activity
NRZ33_RS21040	COG1309	transcriptional regulator
NRZ33_RS21045	COG0668	transmembrane transport
NRZ33_RS21055	COG0166	Belongs to the GPI family
NRZ33_RS21060	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NRZ33_RS21065	COG0583	DNA-binding transcription factor activity
NRZ33_RS21105	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
NRZ33_RS21110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NRZ33_RS21115	COG1739	Uncharacterized protein family UPF0029
NRZ33_RS21120	COG0006	proline dipeptidase activity
NRZ33_RS21125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NRZ33_RS21130	COG1250	3-hydroxyacyl-CoA dehydrogenase
NRZ33_RS21130	COG1024	Enoyl-CoA hydratase
NRZ33_RS21135	COG0183	Belongs to the thiolase family
NRZ33_RS21160	COG0425	Belongs to the sulfur carrier protein TusA family
NRZ33_RS21165	COG0251	oxidation-reduction process
NRZ33_RS21170	COG2885	chlorophyll binding
NRZ33_RS21180	COG2818	Glycosylase
NRZ33_RS21185	COG0752	glycyl-tRNA synthetase alpha subunit
NRZ33_RS21190	COG0751	glycine-tRNA ligase activity
NRZ33_RS21205	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NRZ33_RS21225	COG0814	amino acid
NRZ33_RS21230	COG0348	domain, Protein
NRZ33_RS21235	COG2188	Transcriptional regulator
NRZ33_RS21250	COG1609	Transcriptional regulator
NRZ33_RS21290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NRZ33_RS21315	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NRZ33_RS21330	COG3118	belongs to the thioredoxin family
NRZ33_RS21335	COG0513	Belongs to the DEAD box helicase family
NRZ33_RS21340	COG0248	Ppx GppA phosphatase
NRZ33_RS21350	COG0742	ribosomal rna small subunit methyltransferase
NRZ33_RS21355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRZ33_RS21375	COG3397	chitin binding
NRZ33_RS21385	COG0084	hydrolase, TatD family'
NRZ33_RS21390	COG0805	protein transport
NRZ33_RS21395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NRZ33_RS21405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NRZ33_RS21410	COG3165	ubiquinone biosynthetic process from chorismate
NRZ33_RS21420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NRZ33_RS21425	COG0402	S-adenosylhomocysteine deaminase activity
NRZ33_RS21470	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
NRZ33_RS21475	COG0848	biopolymer transport protein
NRZ33_RS21480	COG0811	peptide transport
NRZ33_RS21485	COG0811	peptide transport
NRZ33_RS21495	COG2771	luxR family
NRZ33_RS21500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NRZ33_RS21505	COG1349	DNA-binding transcription factor activity
NRZ33_RS21510	COG0745	RESPONSE REGULATOR receiver
NRZ33_RS21515	COG2205	protein histidine kinase activity
NRZ33_RS21525	COG4452	Inner membrane protein CreD
NRZ33_RS21530	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NRZ33_RS21535	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NRZ33_RS21540	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NRZ33_RS21545	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NRZ33_RS21550	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NRZ33_RS21555	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NRZ33_RS21560	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NRZ33_RS21570	COG0356	it plays a direct role in the translocation of protons across the membrane
NRZ33_RS21580	COG1475	DNA binding
NRZ33_RS21585	COG1192	Involved in chromosome partitioning
NRZ33_RS21590	COG0357	Ribosomal RNA small subunit methyltransferase G
NRZ33_RS21595	COG0445	tRNA wobble uridine modification
NRZ33_RS21600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NRZ33_RS21605	COG4774	siderophore transport
NRZ33_RS21610	COG4615	Cyclic peptide transporter
NRZ33_RS21615	COG1120	ATPase activity
NRZ33_RS21630	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NRZ33_RS21635	COG0706	membrane insertase activity
NRZ33_RS21640	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NRZ33_RS21645	COG0594	ribonuclease P activity
NRZ33_RS21650	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NRZ33_RS21655	COG1126	abc transporter atp-binding protein