locus-tag	class	description
AhyD4_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AhyD4_RS00010	COG0592	DNA-directed DNA polymerase activity
AhyD4_RS00030	COG2378	regulation of single-species biofilm formation
AhyD4_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
AhyD4_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
AhyD4_RS00045	COG3977	Valine--pyruvate aminotransferase
AhyD4_RS00060	COG2814	Major facilitator Superfamily
AhyD4_RS00065	COG0745	RESPONSE REGULATOR receiver
AhyD4_RS00070	COG2205	protein histidine kinase activity
AhyD4_RS00090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AhyD4_RS00095	COG4191	Histidine kinase
AhyD4_RS00095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AhyD4_RS00100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AhyD4_RS00105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AhyD4_RS00110	COG1309	transcriptional regulator
AhyD4_RS00140	COG0469	pyruvate kinase activity
AhyD4_RS00145	COG2271	Major facilitator Superfamily
AhyD4_RS00170	COG0561	phosphatase activity
AhyD4_RS00175	COG2267	carboxylic ester hydrolase activity
AhyD4_RS00185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AhyD4_RS00190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AhyD4_RS00195	COG1758	RNA polymerase activity
AhyD4_RS00205	COG0859	PFAM glycosyl transferase family 9
AhyD4_RS00210	COG3642	lipopolysaccharide core region biosynthetic process
AhyD4_RS00245	COG0589	response to stress
AhyD4_RS00250	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AhyD4_RS00260	COG1528	Iron-storage protein
AhyD4_RS00265	COG2081	HI0933 family
AhyD4_RS00270	COG2223	nitrite transmembrane transporter activity
AhyD4_RS00290	COG3188	usher protein
AhyD4_RS00310	COG2205	protein histidine kinase activity
AhyD4_RS00310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AhyD4_RS00320	COG3275	phosphorelay sensor kinase activity
AhyD4_RS00325	COG3279	Response regulator of the LytR AlgR family
AhyD4_RS00330	COG2223	nitrite transmembrane transporter activity
AhyD4_RS00335	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AhyD4_RS00340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AhyD4_RS00355	COG0583	DNA-binding transcription factor activity
AhyD4_RS00360	COG4206	TonB-dependent receptor
AhyD4_RS00365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AhyD4_RS00405	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AhyD4_RS00470	COG2003	Belongs to the UPF0758 family
AhyD4_RS00515	COG3311	Transcriptional regulator
AhyD4_RS00535	COG2771	luxR family
AhyD4_RS00585	COG1358	cellular component organization or biogenesis
AhyD4_RS00645	COG0582	viral genome integration into host DNA
AhyD4_RS00650	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AhyD4_RS00655	COG2166	iron-sulfur cluster assembly
AhyD4_RS00660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AhyD4_RS00665	COG0210	DNA helicase
AhyD4_RS00675	COG3245	cytochrome
AhyD4_RS00680	COG1063	alcohol dehydrogenase
AhyD4_RS00685	COG0156	8-amino-7-oxononanoate synthase activity
AhyD4_RS00695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AhyD4_RS00710	COG3306	glycosyltransferase involved in LPS biosynthesis
AhyD4_RS00730	COG1561	YicC-like family, N-terminal region
AhyD4_RS00735	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AhyD4_RS00740	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AhyD4_RS00750	COG0789	Transcriptional regulator
AhyD4_RS00755	COG2203	Gaf domain
AhyD4_RS00755	COG3706	GGDEF domain
AhyD4_RS00755	COG5001	Diguanylate cyclase
AhyD4_RS00755	COG4251	negative regulation of phosphorylation
AhyD4_RS00760	COG3084	Protein conserved in bacteria
AhyD4_RS00770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AhyD4_RS00775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AhyD4_RS00780	COG3639	organic phosphonate transmembrane transporter activity
AhyD4_RS00785	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AhyD4_RS00790	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AhyD4_RS00800	COG1335	isochorismatase
AhyD4_RS00810	COG1683	Conserved Protein
AhyD4_RS00815	COG0204	Acyl-transferase
AhyD4_RS00820	COG0204	Acyl-transferase
AhyD4_RS00825	COG0606	chelatase, subunit chli
AhyD4_RS00835	COG3978	acetolactate synthase activity
AhyD4_RS00845	COG0129	dihydroxy-acid dehydratase activity
AhyD4_RS00865	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AhyD4_RS00870	COG0254	rRNA binding
AhyD4_RS00875	COG0702	epimerase
AhyD4_RS00880	COG0281	malic enzyme
AhyD4_RS00890	COG2205	protein histidine kinase activity
AhyD4_RS00895	COG0745	RESPONSE REGULATOR receiver
AhyD4_RS00900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AhyD4_RS00915	COG0366	Alpha amylase catalytic
AhyD4_RS00930	COG0443	Heat shock 70 kDa protein
AhyD4_RS00935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AhyD4_RS00940	COG3045	CreA protein
AhyD4_RS00960	COG0174	glutamine synthetase
AhyD4_RS00980	COG3842	ATPase activity
AhyD4_RS00985	COG1176	ABC-type spermidine putrescine transport system, permease component I
AhyD4_RS00990	COG1177	transmembrane transport
AhyD4_RS00995	COG2258	MOSC domain
AhyD4_RS01010	COG2050	protein possibly involved in aromatic compounds catabolism
AhyD4_RS01015	COG0514	ATP-dependent DNA helicase (RecQ)
AhyD4_RS01025	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AhyD4_RS01035	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AhyD4_RS01040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AhyD4_RS01050	COG2239	Acts as a magnesium transporter
AhyD4_RS01055	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AhyD4_RS01055	COG1648	precorrin-2 dehydrogenase activity
AhyD4_RS01060	COG2116	formate transmembrane transporter activity
AhyD4_RS01070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AhyD4_RS01085	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AhyD4_RS01090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AhyD4_RS01110	COG1595	DNA-templated transcription, initiation
AhyD4_RS01115	COG3806	Anti-sigma factor
AhyD4_RS01120	COG1968	undecaprenyl-diphosphatase activity
AhyD4_RS01125	COG0667	Aldo Keto reductase
AhyD4_RS01130	COG2017	converts alpha-aldose to the beta-anomer
AhyD4_RS01135	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AhyD4_RS01145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AhyD4_RS01150	COG1609	Transcriptional regulator
AhyD4_RS01155	COG3250	beta-galactosidase activity
AhyD4_RS01175	COG0840	transmembrane signaling receptor activity
AhyD4_RS01200	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AhyD4_RS01205	COG1288	antiporter activity
AhyD4_RS01210	COG1438	arginine binding
AhyD4_RS01215	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AhyD4_RS01220	COG0540	Belongs to the ATCase OTCase family
AhyD4_RS01235	COG0688	phosphatidylethanolamine metabolic process
AhyD4_RS01245	COG3040	lipid binding
AhyD4_RS01250	COG2207	Transcriptional regulator
AhyD4_RS01255	COG1979	alcohol dehydrogenase
AhyD4_RS01260	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AhyD4_RS01265	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AhyD4_RS01275	COG2964	Protein conserved in bacteria
AhyD4_RS01280	COG3681	Belongs to the UPF0597 family
AhyD4_RS01290	COG0446	pyridine nucleotide-disulphide oxidoreductase
AhyD4_RS01295	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AhyD4_RS01300	COG0564	pseudouridine synthase activity
AhyD4_RS01310	COG0542	response to heat
AhyD4_RS01315	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AhyD4_RS01320	COG2502	aspartate--ammonia ligase
AhyD4_RS01325	COG1522	sequence-specific DNA binding
AhyD4_RS01335	COG5413	integral membrane protein
AhyD4_RS01355	COG2205	protein histidine kinase activity
AhyD4_RS01365	COG2204	response regulator
AhyD4_RS01380	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AhyD4_RS01410	COG0243	molybdopterin cofactor binding
AhyD4_RS01415	COG3005	denitrification pathway
AhyD4_RS01420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AhyD4_RS01440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AhyD4_RS01445	COG0569	domain protein
AhyD4_RS01450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AhyD4_RS01475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AhyD4_RS01490	COG0250	Participates in transcription elongation, termination and antitermination
AhyD4_RS01495	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AhyD4_RS01500	COG0081	regulation of translation
AhyD4_RS01505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AhyD4_RS01510	COG0222	ribosome binding
AhyD4_RS01515	COG0085	RNA polymerase activity
AhyD4_RS01520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AhyD4_RS01530	COG2964	Protein conserved in bacteria
AhyD4_RS01535	COG0251	oxidation-reduction process
AhyD4_RS01545	COG2923	Belongs to the DsrF TusC family
AhyD4_RS01550	COG2168	tRNA wobble position uridine thiolation
AhyD4_RS01560	COG0049	tRNA binding
AhyD4_RS01565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AhyD4_RS01570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AhyD4_RS01575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AhyD4_RS01615	COG2252	PERMEase
AhyD4_RS01620	COG2376	Dihydroxyacetone kinase
AhyD4_RS01625	COG1461	Dihydroxyacetone kinase
AhyD4_RS01640	COG3284	Transcriptional regulator
AhyD4_RS01650	COG2957	Belongs to the agmatine deiminase family
AhyD4_RS01655	COG4221	oxidoreductase activity
AhyD4_RS01660	COG0628	permease
AhyD4_RS01665	COG0494	nUDIX hydrolase
AhyD4_RS01690	COG0753	catalase activity
AhyD4_RS01695	COG1247	-acetyltransferase
AhyD4_RS01715	COG2203	Gaf domain
AhyD4_RS01715	COG2199	diguanylate cyclase activity
AhyD4_RS01725	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AhyD4_RS01735	COG1175	transmembrane transport
AhyD4_RS01760	COG0583	DNA-binding transcription factor activity
AhyD4_RS01770	COG1741	Belongs to the pirin family
AhyD4_RS01775	COG2259	Doxx family
AhyD4_RS01780	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AhyD4_RS01785	COG1074	ATP-dependent DNA helicase activity
AhyD4_RS01790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AhyD4_RS01795	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AhyD4_RS01800	COG0346	lactoylglutathione lyase activity
AhyD4_RS01845	COG2203	Gaf domain
AhyD4_RS01845	COG5001	Diguanylate cyclase
AhyD4_RS01845	COG3706	GGDEF domain
AhyD4_RS01845	COG4251	negative regulation of phosphorylation
AhyD4_RS01850	COG4771	TonB-dependent receptor
AhyD4_RS01855	COG1278	Cold shock
AhyD4_RS01875	COG0629	single-stranded DNA binding
AhyD4_RS01880	COG2197	response regulator
AhyD4_RS01885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AhyD4_RS01895	COG3047	cAMP biosynthetic process
AhyD4_RS01900	COG0840	transmembrane signaling receptor activity
AhyD4_RS01925	COG3135	benzoate transporter
AhyD4_RS01930	COG1396	sequence-specific DNA binding
AhyD4_RS01960	COG2926	Belongs to the UPF0265 family
AhyD4_RS01970	COG3028	Belongs to the UPF0307 family
AhyD4_RS01975	COG0312	modulator of DNA gyrase
AhyD4_RS01980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AhyD4_RS01985	COG5007	Belongs to the BolA IbaG family
AhyD4_RS01995	COG2854	intermembrane phospholipid transfer
AhyD4_RS02000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AhyD4_RS02005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AhyD4_RS02010	COG1127	ABC transporter
AhyD4_RS02015	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AhyD4_RS02015	COG0517	IMP dehydrogenase activity
AhyD4_RS02020	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AhyD4_RS02025	COG3117	lipopolysaccharide transmembrane transporter activity
AhyD4_RS02030	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AhyD4_RS02035	COG1137	ATPase activity
AhyD4_RS02040	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AhyD4_RS02050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhyD4_RS02055	COG1660	Displays ATPase and GTPase activities
AhyD4_RS02060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhyD4_RS02065	COG3711	transcriptional antiterminator
AhyD4_RS02065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhyD4_RS02080	COG3964	amidohydrolase
AhyD4_RS02110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AhyD4_RS02115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AhyD4_RS02125	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AhyD4_RS02130	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AhyD4_RS02135	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AhyD4_RS02140	COG0723	plastoquinol--plastocyanin reductase activity
AhyD4_RS02145	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AhyD4_RS02150	COG2857	Cytochrome c1
AhyD4_RS02155	COG0625	glutathione transferase activity
AhyD4_RS02160	COG2969	positive regulation of protein catabolic process
AhyD4_RS02165	COG2823	Periplasmic or secreted lipoprotein
AhyD4_RS02170	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AhyD4_RS02175	COG0792	nuclease activity
AhyD4_RS02180	COG3107	peptidoglycan biosynthetic process
AhyD4_RS02185	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AhyD4_RS02195	COG2001	Belongs to the MraZ family
AhyD4_RS02200	COG0275	rRNA processing
AhyD4_RS02205	COG3116	cell division
AhyD4_RS02210	COG0768	penicillin binding
AhyD4_RS02220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AhyD4_RS02225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AhyD4_RS02230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AhyD4_RS02235	COG0772	Belongs to the SEDS family
AhyD4_RS02240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AhyD4_RS02245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AhyD4_RS02250	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AhyD4_RS02255	COG0849	cell division
AhyD4_RS02260	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AhyD4_RS02265	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AhyD4_RS02275	COG0653	protein targeting
AhyD4_RS02285	COG0494	nUDIX hydrolase
AhyD4_RS02290	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AhyD4_RS02295	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AhyD4_RS02310	COG1459	type II secretion system
AhyD4_RS02315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AhyD4_RS02340	COG2186	Transcriptional regulator
AhyD4_RS02345	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AhyD4_RS02350	COG0508	dehydrogenase complex catalyzes the overall conversion of
AhyD4_RS02355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AhyD4_RS02360	COG3447	MASE1 domain protein
AhyD4_RS02360	COG5001	Diguanylate cyclase
AhyD4_RS02360	COG5002	protein histidine kinase activity
AhyD4_RS02370	COG0840	transmembrane signaling receptor activity
AhyD4_RS02375	COG0840	transmembrane signaling receptor activity
AhyD4_RS02380	COG1752	Esterase of the alpha-beta hydrolase superfamily
AhyD4_RS02385	COG1049	propionate catabolic process, 2-methylcitrate cycle
AhyD4_RS02400	COG1280	lysine exporter protein (LysE YggA)
AhyD4_RS02410	COG0523	cobalamin synthesis protein
AhyD4_RS02415	COG0477	Major facilitator Superfamily
AhyD4_RS02430	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AhyD4_RS02435	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AhyD4_RS02475	COG3314	Sporulation integral membrane protein YlbJ
AhyD4_RS02480	COG0784	Response regulator, receiver
AhyD4_RS02480	COG0835	chemotaxis
AhyD4_RS02485	COG1028	Short-chain dehydrogenase reductase Sdr
AhyD4_RS02490	COG1444	tRNA N-acetyltransferase activity
AhyD4_RS02515	COG1803	Methylglyoxal synthase
AhyD4_RS02530	COG0252	asparaginase activity
AhyD4_RS02550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AhyD4_RS02550	COG1263	PTS System
AhyD4_RS02555	COG0366	Alpha amylase catalytic
AhyD4_RS02560	COG0110	maltose O-acetyltransferase activity
AhyD4_RS02565	COG1522	sequence-specific DNA binding
AhyD4_RS02570	COG5006	permease, DMT superfamily
AhyD4_RS02580	COG1012	belongs to the aldehyde dehydrogenase family
AhyD4_RS02585	COG1177	transmembrane transport
AhyD4_RS02590	COG1176	ABC-type spermidine putrescine transport system, permease component I
AhyD4_RS02595	COG3842	ATPase activity
AhyD4_RS02600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AhyD4_RS02605	COG0583	DNA-binding transcription factor activity
AhyD4_RS02610	COG1757	Na H antiporter
AhyD4_RS02650	COG0297	glycogen (starch) synthase activity
AhyD4_RS02655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AhyD4_RS02660	COG2813	Specifically methylates the guanine in position
AhyD4_RS02665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AhyD4_RS02670	COG3706	GGDEF domain
AhyD4_RS02670	COG5001	Diguanylate cyclase
AhyD4_RS02670	COG2203	Gaf domain
AhyD4_RS02670	COG4251	negative regulation of phosphorylation
AhyD4_RS02680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AhyD4_RS02690	COG2995	paraquat-inducible protein a
AhyD4_RS02695	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AhyD4_RS02695	COG3008	intermembrane lipid transfer
AhyD4_RS02700	COG3009	Protein conserved in bacteria
AhyD4_RS02715	COG3240	lipase activity
AhyD4_RS02720	COG3111	PFAM Bacterial OB fold (BOF) protein
AhyD4_RS02730	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AhyD4_RS02735	COG1194	a g-specific adenine glycosylase
AhyD4_RS02745	COG3409	Peptidoglycan-binding domain 1 protein
AhyD4_RS02745	COG3267	Type II secretory pathway component ExeA
AhyD4_RS02755	COG0617	tRNA 3'-terminal CCA addition
AhyD4_RS02770	COG1346	cytolysis
AhyD4_RS02775	COG1380	Effector of murein hydrolase LrgA
AhyD4_RS02780	COG0583	DNA-binding transcription factor activity
AhyD4_RS02805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AhyD4_RS02810	COG0306	phosphate transporter
AhyD4_RS02815	COG1392	Phosphate transport regulator
AhyD4_RS02830	COG1560	Kdo2-lipid A biosynthetic process
AhyD4_RS02835	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AhyD4_RS02835	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AhyD4_RS02840	COG1538	Outer membrane efflux protein
AhyD4_RS02845	COG0494	nUDIX hydrolase
AhyD4_RS02850	COG3151	Protein conserved in bacteria
AhyD4_RS02860	COG3150	esterase
AhyD4_RS02865	COG1051	belongs to the nudix hydrolase family
AhyD4_RS02880	COG1566	PFAM secretion protein HlyD family protein
AhyD4_RS02885	COG1289	transmembrane transporter activity
AhyD4_RS02935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AhyD4_RS02960	COG0204	Acyl-transferase
AhyD4_RS02965	COG1842	Phage shock protein A
AhyD4_RS02980	COG2827	Endonuclease containing a URI domain
AhyD4_RS02990	COG2962	Rard protein
AhyD4_RS02995	COG1573	uracil-dna glycosylase
AhyD4_RS03000	COG0697	spore germination
AhyD4_RS03010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AhyD4_RS03015	COG1121	(ABC) transporter
AhyD4_RS03020	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AhyD4_RS03040	COG0739	heme binding
AhyD4_RS03050	COG3068	Protein conserved in bacteria
AhyD4_RS03070	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AhyD4_RS03085	COG1546	Belongs to the CinA family
AhyD4_RS03090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AhyD4_RS03100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AhyD4_RS03105	COG0527	aspartate kinase activity
AhyD4_RS03110	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AhyD4_RS03145	COG1686	Belongs to the peptidase S11 family
AhyD4_RS03150	COG0586	Pfam SNARE associated Golgi protein
AhyD4_RS03155	COG1253	flavin adenine dinucleotide binding
AhyD4_RS03160	COG0525	valine-tRNA ligase activity
AhyD4_RS03165	COG2927	DNA polymerase III (CHI subunit)
AhyD4_RS03170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AhyD4_RS03175	COG0795	lipopolysaccharide-transporting ATPase activity
AhyD4_RS03180	COG0795	lipopolysaccharide-transporting ATPase activity
AhyD4_RS03195	COG0582	viral genome integration into host DNA
AhyD4_RS03210	COG3561	AntA/AntB antirepressor
AhyD4_RS03235	COG0004	ammonium transporteR
AhyD4_RS03240	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AhyD4_RS03245	COG2165	general secretion pathway protein
AhyD4_RS03250	COG0084	hydrolase, TatD family'
AhyD4_RS03255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AhyD4_RS03265	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AhyD4_RS03270	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AhyD4_RS03275	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AhyD4_RS03280	COG0813	purine-nucleoside phosphorylase activity
AhyD4_RS03285	COG5002	protein histidine kinase activity
AhyD4_RS03285	COG3447	MASE1 domain protein
AhyD4_RS03285	COG5001	Diguanylate cyclase
AhyD4_RS03295	COG0560	Phosphoserine phosphatase
AhyD4_RS03320	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AhyD4_RS03325	COG0776	regulation of translation
AhyD4_RS03335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AhyD4_RS03365	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AhyD4_RS03370	COG0513	Belongs to the DEAD box helicase family
AhyD4_RS03375	COG3022	response to hydroperoxide
AhyD4_RS03390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AhyD4_RS03395	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AhyD4_RS03400	COG0762	integral membrane protein
AhyD4_RS03405	COG1872	DUF167
AhyD4_RS03420	COG4166	transmembrane transport
AhyD4_RS03430	COG0110	maltose O-acetyltransferase activity
AhyD4_RS03440	COG1024	Enoyl-CoA hydratase
AhyD4_RS03455	COG4221	oxidoreductase activity
AhyD4_RS03460	COG0442	prolyl-tRNA aminoacylation
AhyD4_RS03465	COG0840	transmembrane signaling receptor activity
AhyD4_RS03470	COG0632	four-way junction helicase activity
AhyD4_RS03475	COG2255	four-way junction helicase activity
AhyD4_RS03480	COG1271	oxidase subunit
AhyD4_RS03485	COG1294	oxidase, subunit
AhyD4_RS03490	COG4890	Cyd operon protein YbgT
AhyD4_RS03495	COG3790	cyd operon protein YbgE
AhyD4_RS03500	COG0824	Thioesterase
AhyD4_RS03505	COG0811	peptide transport
AhyD4_RS03520	COG0823	Involved in the tonB-independent uptake of proteins
AhyD4_RS03525	COG2885	chlorophyll binding
AhyD4_RS03530	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AhyD4_RS03585	COG0840	transmembrane signaling receptor activity
AhyD4_RS03590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AhyD4_RS03595	COG0676	glucose-6-phosphate 1-epimerase activity
AhyD4_RS03600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AhyD4_RS03605	COG1640	4-alpha-glucanotransferase
AhyD4_RS03610	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AhyD4_RS03630	COG1051	belongs to the nudix hydrolase family
AhyD4_RS03635	COG2130	NADP-dependent
AhyD4_RS03640	COG1764	response to oxidative stress
AhyD4_RS03645	COG1846	Transcriptional regulator
AhyD4_RS03675	COG0561	phosphatase activity
AhyD4_RS03690	COG0733	neurotransmitter:sodium symporter activity
AhyD4_RS03700	COG0733	neurotransmitter:sodium symporter activity
AhyD4_RS03725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AhyD4_RS03740	COG1794	racemase activity, acting on amino acids and derivatives
AhyD4_RS03755	COG2731	YhcH YjgK YiaL family protein
AhyD4_RS03765	COG0668	transmembrane transport
AhyD4_RS03775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AhyD4_RS03810	COG0583	DNA-binding transcription factor activity
AhyD4_RS03815	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AhyD4_RS03825	COG0488	(ABC) transporter
AhyD4_RS03830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AhyD4_RS03830	COG0517	IMP dehydrogenase activity
AhyD4_RS03835	COG1585	Membrane protein implicated in regulation of membrane protease activity
AhyD4_RS03840	COG0330	HflC and HflK could
AhyD4_RS03845	COG1648	precorrin-2 dehydrogenase activity
AhyD4_RS03845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AhyD4_RS03850	COG0175	sulfate reduction
AhyD4_RS03855	COG2895	sulfate adenylyltransferase (ATP) activity
AhyD4_RS03860	COG3273	potassium ion transport
AhyD4_RS03860	COG0471	metal ion transport
AhyD4_RS03865	COG0529	Catalyzes the synthesis of activated sulfate
AhyD4_RS03885	COG0840	transmembrane signaling receptor activity
AhyD4_RS03905	COG1136	(ABC) transporter
AhyD4_RS03920	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AhyD4_RS03935	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AhyD4_RS03940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AhyD4_RS03945	COG0163	prenyltransferase activity
AhyD4_RS03960	COG1131	(ABC) transporter
AhyD4_RS03965	COG0842	Transport permease protein
AhyD4_RS03970	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
AhyD4_RS03975	COG1924	4 iron, 4 sulfur cluster binding
AhyD4_RS03995	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AhyD4_RS04000	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AhyD4_RS04015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AhyD4_RS04020	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AhyD4_RS04025	COG1489	DNA binding
AhyD4_RS04035	COG1643	Atp-dependent helicase
AhyD4_RS04040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AhyD4_RS04045	COG0346	lactoylglutathione lyase activity
AhyD4_RS04055	COG2076	Multidrug Resistance protein
AhyD4_RS04065	COG0784	Response regulator, receiver
AhyD4_RS04065	COG3437	response regulator, receiver
AhyD4_RS04075	COG0671	phosphoesterase, PA-phosphatase related
AhyD4_RS04090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AhyD4_RS04095	COG0038	chloride channel
AhyD4_RS04105	COG0316	Belongs to the HesB IscA family
AhyD4_RS04130	COG1280	lysine exporter protein (LysE YggA)
AhyD4_RS04135	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AhyD4_RS04150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AhyD4_RS04180	COG0745	RESPONSE REGULATOR receiver
AhyD4_RS04185	COG3104	oligopeptide transport
AhyD4_RS04190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AhyD4_RS04195	COG1555	photosystem II stabilization
AhyD4_RS04205	COG2350	Protein conserved in bacteria
AhyD4_RS04210	COG2917	probably involved in intracellular septation
AhyD4_RS04215	COG0076	glutamate decarboxylase activity
AhyD4_RS04220	COG1272	protein, Hemolysin III
AhyD4_RS04225	COG2985	domain, Protein
AhyD4_RS04225	COG0569	domain protein
AhyD4_RS04240	COG0784	Response regulator, receiver
AhyD4_RS04240	COG0835	chemotaxis
AhyD4_RS04245	COG2755	lipolytic protein G-D-S-L family
AhyD4_RS04250	COG4181	ATPase activity
AhyD4_RS04255	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AhyD4_RS04260	COG1090	epimerase
AhyD4_RS04265	COG2200	EAL domain
AhyD4_RS04270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AhyD4_RS04275	COG2234	aminopeptidase activity
AhyD4_RS04275	COG4935	Belongs to the peptidase S8 family
AhyD4_RS04280	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AhyD4_RS04285	COG3171	Protein conserved in bacteria
AhyD4_RS04290	COG2066	Belongs to the glutaminase family
AhyD4_RS04295	COG2897	thiosulfate sulfurtransferase activity
AhyD4_RS04300	COG1404	Belongs to the peptidase S8 family
AhyD4_RS04310	COG1132	(ABC) transporter
AhyD4_RS04335	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
AhyD4_RS04340	COG5001	Diguanylate cyclase
AhyD4_RS04340	COG3300	MHYT domain
AhyD4_RS04360	COG4628	conserved protein (DUF2132)
AhyD4_RS04365	COG0688	phosphatidylethanolamine metabolic process
AhyD4_RS04370	COG1162	GTPase activity
AhyD4_RS04375	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AhyD4_RS04410	COG1278	Cold shock
AhyD4_RS04420	COG0840	transmembrane signaling receptor activity
AhyD4_RS04425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AhyD4_RS04430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AhyD4_RS04475	COG0848	biopolymer transport protein
AhyD4_RS04480	COG0811	peptide transport
AhyD4_RS04485	COG0811	peptide transport
AhyD4_RS04500	COG4174	ABC transporter (Permease)
AhyD4_RS04505	COG4239	(ABC) transporter, permease
AhyD4_RS04515	COG0444	Belongs to the ABC transporter superfamily
AhyD4_RS04520	COG4608	Belongs to the ABC transporter superfamily
AhyD4_RS04525	COG2195	Cleaves the N-terminal amino acid of tripeptides
AhyD4_RS04530	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AhyD4_RS04535	COG1073	alpha beta
AhyD4_RS04550	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AhyD4_RS04575	COG0243	molybdopterin cofactor binding
AhyD4_RS04590	COG1116	anion transmembrane transporter activity
AhyD4_RS04590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AhyD4_RS04595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AhyD4_RS04600	COG1116	anion transmembrane transporter activity
AhyD4_RS04605	COG2146	nitrite reductase [NAD(P)H] activity
AhyD4_RS04605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AhyD4_RS04610	COG2146	nitrite reductase [NAD(P)H] activity
AhyD4_RS04610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AhyD4_RS04615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AhyD4_RS04620	COG2313	pseudouridylate synthase activity
AhyD4_RS04630	COG1858	cytochrome C peroxidase
AhyD4_RS04665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AhyD4_RS04670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AhyD4_RS04695	COG2986	histidine ammonia-lyase
AhyD4_RS04720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AhyD4_RS04730	COG1028	Short-chain dehydrogenase reductase Sdr
AhyD4_RS04745	COG0521	Mo-molybdopterin cofactor biosynthetic process
AhyD4_RS04755	COG2966	Psort location CytoplasmicMembrane, score
AhyD4_RS04760	COG3610	response to peptide
AhyD4_RS04770	COG4175	Glycine betaine
AhyD4_RS04775	COG4176	ABC-type proline glycine betaine transport system permease component
AhyD4_RS04780	COG2113	Glycine betaine
AhyD4_RS04785	COG0175	sulfate reduction
AhyD4_RS04790	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AhyD4_RS04795	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AhyD4_RS04800	COG0384	phenazine biosynthesis protein PhzF
AhyD4_RS04805	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AhyD4_RS04810	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AhyD4_RS04820	COG0786	glutamate:sodium symporter activity
AhyD4_RS04825	COG0252	asparaginase activity
AhyD4_RS04830	COG3139	Protein of unknown function (DUF1315)
AhyD4_RS04850	COG0616	signal peptide processing
AhyD4_RS04855	COG1902	pentaerythritol trinitrate reductase activity
AhyD4_RS04855	COG0446	pyridine nucleotide-disulphide oxidoreductase
AhyD4_RS04860	COG0778	Nitroreductase
AhyD4_RS04875	COG2264	protein methyltransferase activity
AhyD4_RS04880	COG0604	alcohol dehydrogenase
AhyD4_RS04885	COG0583	DNA-binding transcription factor activity
AhyD4_RS04890	COG1263	PTS System
AhyD4_RS04890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AhyD4_RS04890	COG2190	(PTS) system
AhyD4_RS04895	COG4145	pantothenate transmembrane transporter activity
AhyD4_RS04905	COG0439	Biotin carboxylase
AhyD4_RS04910	COG0511	ligase activity, forming carbon-carbon bonds
AhyD4_RS04915	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AhyD4_RS04920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AhyD4_RS04930	COG3300	MHYT domain
AhyD4_RS04930	COG5001	Diguanylate cyclase
AhyD4_RS04950	COG3381	protein complex oligomerization
AhyD4_RS04965	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AhyD4_RS04980	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AhyD4_RS04985	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AhyD4_RS04985	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AhyD4_RS05005	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AhyD4_RS05010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AhyD4_RS05015	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AhyD4_RS05020	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AhyD4_RS05025	COG4172	Belongs to the ABC transporter superfamily
AhyD4_RS05035	COG0601	transmembrane transport
AhyD4_RS05045	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AhyD4_RS05050	COG0142	geranyltranstransferase activity
AhyD4_RS05055	COG1722	exodeoxyribonuclease VII activity
AhyD4_RS05060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AhyD4_RS05065	COG1360	Flagellar Motor Protein
AhyD4_RS05080	COG1534	Rna-binding protein
AhyD4_RS05085	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AhyD4_RS05095	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AhyD4_RS05100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AhyD4_RS05105	COG0149	triose-phosphate isomerase activity
AhyD4_RS05110	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AhyD4_RS05125	COG0779	Required for maturation of 30S ribosomal subunits
AhyD4_RS05130	COG0195	Participates in both transcription termination and antitermination
AhyD4_RS05135	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AhyD4_RS05140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AhyD4_RS05145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AhyD4_RS05150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AhyD4_RS05155	COG1185	polyribonucleotide nucleotidyltransferase activity
AhyD4_RS05170	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AhyD4_RS05180	COG0114	fumarate hydratase activity
AhyD4_RS05190	COG1966	Carbon starvation protein
AhyD4_RS05195	COG3279	Response regulator of the LytR AlgR family
AhyD4_RS05265	COG0312	modulator of DNA gyrase
AhyD4_RS05270	COG0312	modulator of DNA gyrase
AhyD4_RS05280	COG4974	Belongs to the 'phage' integrase family
AhyD4_RS05285	COG1970	mechanosensitive ion channel activity
AhyD4_RS05290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AhyD4_RS05300	COG0789	Transcriptional regulator
AhyD4_RS05315	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AhyD4_RS05320	COG3545	Serine hydrolase
AhyD4_RS05330	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AhyD4_RS05335	COG0321	lipoyl(octanoyl) transferase activity
AhyD4_RS05340	COG2921	Belongs to the UPF0250 family
AhyD4_RS05345	COG1686	Belongs to the peptidase S11 family
AhyD4_RS05350	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AhyD4_RS05355	COG2951	lytic endotransglycosylase activity
AhyD4_RS05360	COG0772	Belongs to the SEDS family
AhyD4_RS05365	COG0768	penicillin binding
AhyD4_RS05370	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AhyD4_RS05375	COG0799	negative regulation of ribosome biogenesis
AhyD4_RS05380	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AhyD4_RS05395	COG0495	leucyl-tRNA aminoacylation
AhyD4_RS05400	COG2888	peptidyl-tyrosine sulfation
AhyD4_RS05405	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AhyD4_RS05410	COG4535	Mg2 and Co2 transporter CorC
AhyD4_RS05415	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AhyD4_RS05420	COG1702	phosphate starvation-inducible protein PhoH
AhyD4_RS05425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AhyD4_RS05430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AhyD4_RS05435	COG1335	isochorismatase
AhyD4_RS05445	COG3706	GGDEF domain
AhyD4_RS05460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AhyD4_RS05480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AhyD4_RS05490	COG3647	Membrane
AhyD4_RS05495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AhyD4_RS05505	COG0516	GMP reductase activity
AhyD4_RS05515	COG0642	Histidine kinase
AhyD4_RS05555	COG3214	Protein conserved in bacteria
AhyD4_RS05580	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AhyD4_RS05585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AhyD4_RS05590	COG1053	succinate dehydrogenase
AhyD4_RS05600	COG0584	glycerophosphoryl diester phosphodiesterase
AhyD4_RS05605	COG3264	Mechanosensitive ion channel
AhyD4_RS05605	COG1511	domain protein
AhyD4_RS05615	COG0739	heme binding
AhyD4_RS05630	COG0583	DNA-binding transcription factor activity
AhyD4_RS05650	COG0583	DNA-binding transcription factor activity
AhyD4_RS05655	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AhyD4_RS05685	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AhyD4_RS05690	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AhyD4_RS05700	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AhyD4_RS05705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AhyD4_RS05715	COG0180	Tryptophanyl-tRNA synthetase
AhyD4_RS05730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AhyD4_RS05740	COG1012	belongs to the aldehyde dehydrogenase family
AhyD4_RS05750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AhyD4_RS05760	COG0674	pyruvate-flavodoxin oxidoreductase activity
AhyD4_RS05760	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AhyD4_RS05760	COG1013	pyruvate-flavodoxin oxidoreductase activity
AhyD4_RS05760	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AhyD4_RS05770	COG0366	Alpha amylase catalytic
AhyD4_RS05790	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AhyD4_RS05800	COG0490	domain, Protein
AhyD4_RS05800	COG0471	metal ion transport
AhyD4_RS05845	COG0012	GTP binding
AhyD4_RS05850	COG0193	aminoacyl-tRNA hydrolase activity
AhyD4_RS05855	COG0737	Belongs to the 5'-nucleotidase family
AhyD4_RS05860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AhyD4_RS05870	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AhyD4_RS05875	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AhyD4_RS05880	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AhyD4_RS05885	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AhyD4_RS05890	COG2890	protein-(glutamine-N5) methyltransferase activity
AhyD4_RS05900	COG2912	Transglutaminase-like superfamily
AhyD4_RS05905	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AhyD4_RS05910	COG1301	dicarboxylic acid transport
AhyD4_RS05920	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AhyD4_RS05935	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AhyD4_RS05940	COG1115	amino acid carrier protein
AhyD4_RS05955	COG0714	Associated with various cellular activities
AhyD4_RS05965	COG3104	oligopeptide transport
AhyD4_RS05970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AhyD4_RS05975	COG1678	Uncharacterized ACR, COG1678
AhyD4_RS05985	COG0189	ligase activity
AhyD4_RS05990	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AhyD4_RS06000	COG3091	SprT-like family
AhyD4_RS06010	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AhyD4_RS06020	COG2200	EAL domain
AhyD4_RS06045	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AhyD4_RS06050	COG0739	heme binding
AhyD4_RS06055	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AhyD4_RS06060	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AhyD4_RS06060	COG3408	Glycogen debranching enzyme
AhyD4_RS06070	COG1881	PFAM PEBP family protein
AhyD4_RS06075	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AhyD4_RS06080	COG0583	DNA-binding transcription factor activity
AhyD4_RS06090	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AhyD4_RS06100	COG0583	DNA-binding transcription factor activity
AhyD4_RS06105	COG1028	Short-chain dehydrogenase reductase Sdr
AhyD4_RS06110	COG0616	signal peptide processing
AhyD4_RS06115	COG3724	N-succinylarginine dihydrolase activity
AhyD4_RS06135	COG0840	transmembrane signaling receptor activity
AhyD4_RS06145	COG2971	BadF BadG BcrA BcrD
AhyD4_RS06155	COG4608	Belongs to the ABC transporter superfamily
AhyD4_RS06160	COG0444	Belongs to the ABC transporter superfamily
AhyD4_RS06165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AhyD4_RS06170	COG0601	transmembrane transport
AhyD4_RS06175	COG4166	transmembrane transport
AhyD4_RS06180	COG2205	protein histidine kinase activity
AhyD4_RS06180	COG0784	Response regulator, receiver
AhyD4_RS06210	COG3220	belongs to the UPF0276 family
AhyD4_RS06240	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AhyD4_RS06245	COG1289	transmembrane transporter activity
AhyD4_RS06250	COG0303	'Molybdopterin
AhyD4_RS06255	COG0746	molybdenum cofactor guanylyltransferase activity
AhyD4_RS06265	COG4662	Binding-protein-dependent transport system inner membrane component
AhyD4_RS06275	COG2204	response regulator
AhyD4_RS06280	COG3852	Histidine kinase
AhyD4_RS06285	COG1910	domain protein
AhyD4_RS06290	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AhyD4_RS06325	COG3383	formate dehydrogenase (NAD+) activity
AhyD4_RS06325	COG3383	formate dehydrogenase (NAD+) activity
AhyD4_RS06330	COG0437	4 iron, 4 sulfur cluster binding
AhyD4_RS06345	COG0281	malic enzyme
AhyD4_RS06365	COG2706	6-phosphogluconolactonase activity
AhyD4_RS06375	COG3264	Mechanosensitive ion channel
AhyD4_RS06375	COG1196	nuclear chromosome segregation
AhyD4_RS06380	COG0469	pyruvate kinase activity
AhyD4_RS06395	COG4651	solute:proton antiporter activity
AhyD4_RS06395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AhyD4_RS06405	COG2974	May be involved in recombination
AhyD4_RS06415	COG0420	3'-5' exonuclease activity
AhyD4_RS06420	COG0419	ATPase involved in DNA repair
AhyD4_RS06435	COG3038	cytochrome b561
AhyD4_RS06450	COG2190	(PTS) system
AhyD4_RS06460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhyD4_RS06465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AhyD4_RS06470	COG0542	response to heat
AhyD4_RS06485	COG1720	tRNA m6t6A37 methyltransferase activity
AhyD4_RS06505	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AhyD4_RS06510	COG4988	ABC transporter
AhyD4_RS06525	COG0745	RESPONSE REGULATOR receiver
AhyD4_RS06535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AhyD4_RS06550	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AhyD4_RS06555	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AhyD4_RS06565	COG0083	homoserine kinase activity
AhyD4_RS06570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AhyD4_RS06575	COG4319	ketosteroid isomerase
AhyD4_RS06590	COG0488	(ABC) transporter
AhyD4_RS06600	COG0813	purine-nucleoside phosphorylase activity
AhyD4_RS06615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AhyD4_RS06615	COG2205	protein histidine kinase activity
AhyD4_RS06620	COG3384	dioxygenase
AhyD4_RS06630	COG1283	sodium-dependent phosphate transmembrane transporter activity
AhyD4_RS06640	COG0531	amino acid
AhyD4_RS06650	COG0531	amino acid
AhyD4_RS06665	COG1917	Cupin 2, conserved barrel domain protein
AhyD4_RS06665	COG1396	sequence-specific DNA binding
AhyD4_RS06670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AhyD4_RS06690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AhyD4_RS06700	COG2375	cellular response to nickel ion
AhyD4_RS06710	COG1136	(ABC) transporter
AhyD4_RS06710	COG0577	efflux transmembrane transporter activity
AhyD4_RS06715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AhyD4_RS06725	COG1227	inorganic diphosphatase activity
AhyD4_RS06735	COG0497	DNA recombination
AhyD4_RS06740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AhyD4_RS06745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AhyD4_RS06750	COG0443	Heat shock 70 kDa protein
AhyD4_RS06755	COG0484	heat shock protein binding
AhyD4_RS06785	COG1285	pathogenesis
AhyD4_RS06800	COG0640	Transcriptional regulator
AhyD4_RS06830	COG0095	Lipoate-protein ligase
AhyD4_RS06850	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AhyD4_RS06855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AhyD4_RS06875	COG0708	Exodeoxyribonuclease III
AhyD4_RS06890	COG2211	Major facilitator Superfamily
AhyD4_RS06935	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AhyD4_RS06940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AhyD4_RS06945	COG1845	cytochrome c oxidase, subunit III
AhyD4_RS06950	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AhyD4_RS06955	COG0109	protoheme IX farnesyltransferase activity
AhyD4_RS06960	COG2814	Major facilitator Superfamily
AhyD4_RS06970	COG2205	protein histidine kinase activity
AhyD4_RS06970	COG0784	Response regulator, receiver
AhyD4_RS06970	COG2198	Histidine kinase
AhyD4_RS06975	COG1879	ABC-type sugar transport system periplasmic component
AhyD4_RS06985	COG0745	RESPONSE REGULATOR receiver
AhyD4_RS07000	COG3381	protein complex oligomerization
AhyD4_RS07040	COG2003	Belongs to the UPF0758 family
AhyD4_RS07080	COG0583	DNA-binding transcription factor activity
AhyD4_RS07095	COG0549	Belongs to the carbamate kinase family
AhyD4_RS07100	COG1304	FMN binding
AhyD4_RS07105	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AhyD4_RS07110	COG1335	isochorismatase
AhyD4_RS07125	COG3311	Transcriptional regulator
AhyD4_RS07145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AhyD4_RS07175	COG0159	tryptophan synthase activity
AhyD4_RS07180	COG0133	tryptophan synthase activity
AhyD4_RS07185	COG0134	indole-3-glycerol-phosphate synthase activity
AhyD4_RS07185	COG0135	phosphoribosylanthranilate isomerase activity
AhyD4_RS07190	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AhyD4_RS07195	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AhyD4_RS07195	COG0512	Glutamine amidotransferase of anthranilate synthase
AhyD4_RS07200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AhyD4_RS07210	COG0009	L-threonylcarbamoyladenylate synthase
AhyD4_RS07220	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AhyD4_RS07230	COG1946	Acyl-CoA thioesterase
AhyD4_RS07245	COG1309	transcriptional regulator
AhyD4_RS07250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AhyD4_RS07255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AhyD4_RS07265	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AhyD4_RS07275	COG2244	polysaccharide biosynthetic process
AhyD4_RS07290	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AhyD4_RS07295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AhyD4_RS07300	COG0662	Cupin 2, conserved barrel domain protein
AhyD4_RS07300	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AhyD4_RS07315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AhyD4_RS07320	COG1091	dTDP-4-dehydrorhamnose reductase activity
AhyD4_RS07325	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AhyD4_RS07335	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
AhyD4_RS07355	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AhyD4_RS07365	COG3132	Protein of unknown function, DUF480
AhyD4_RS07405	COG1278	Cold shock
AhyD4_RS07435	COG0697	spore germination
AhyD4_RS07440	COG1349	DNA-binding transcription factor activity
AhyD4_RS07445	COG1882	Formate acetyltransferase
AhyD4_RS07450	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AhyD4_RS07455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AhyD4_RS07485	COG0622	Phosphoesterase
AhyD4_RS07500	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
AhyD4_RS07505	COG0784	Response regulator, receiver
AhyD4_RS07505	COG0835	chemotaxis
AhyD4_RS07510	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AhyD4_RS07515	COG1815	bacterial-type flagellum-dependent cell motility
AhyD4_RS07535	COG4787	bacterial-type flagellum-dependent cell motility
AhyD4_RS07545	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AhyD4_RS07550	COG1706	bacterial-type flagellum-dependent cell motility
AhyD4_RS07555	COG1705	Flagellar rod assembly protein muramidase FlgJ
AhyD4_RS07555	COG3951	Flagellar rod assembly protein muramidase FlgJ
AhyD4_RS07560	COG1256	bacterial-type flagellum assembly
AhyD4_RS07570	COG2239	Acts as a magnesium transporter
AhyD4_RS07580	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AhyD4_RS07585	COG2716	regulation of RNA biosynthetic process
AhyD4_RS07610	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AhyD4_RS07615	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AhyD4_RS07620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AhyD4_RS07625	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AhyD4_RS07645	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AhyD4_RS07655	COG0590	tRNA wobble adenosine to inosine editing
AhyD4_RS07660	COG0573	inorganic phosphate transmembrane transporter activity
AhyD4_RS07665	COG0581	inorganic phosphate transmembrane transporter activity
AhyD4_RS07670	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AhyD4_RS07675	COG0704	Plays a role in the regulation of phosphate uptake
AhyD4_RS07680	COG1253	flavin adenine dinucleotide binding
AhyD4_RS07695	COG0531	amino acid
AhyD4_RS07710	COG1126	abc transporter atp-binding protein
AhyD4_RS07715	COG0765	amino acid transport
AhyD4_RS07720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AhyD4_RS07730	COG2271	Major facilitator Superfamily
AhyD4_RS07745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AhyD4_RS07775	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AhyD4_RS07780	COG0477	Major facilitator Superfamily
AhyD4_RS07785	COG0123	including yeast histone deacetylase and acetoin utilization protein
AhyD4_RS07795	COG1199	ATP-dependent helicase activity
AhyD4_RS07810	COG1448	Aminotransferase
AhyD4_RS07815	COG0433	COG0433 Predicted ATPase
AhyD4_RS07885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AhyD4_RS07895	COG1522	sequence-specific DNA binding
AhyD4_RS07920	COG5642	Protein of unknown function (DUF2384)
AhyD4_RS07925	COG2916	Histone family protein nucleoid-structuring protein H-NS
AhyD4_RS07960	COG2333	competence protein COMEC
AhyD4_RS07960	COG0658	competence protein
AhyD4_RS07970	COG1663	tetraacyldisaccharide 4'-kinase activity
AhyD4_RS07975	COG2835	tetraacyldisaccharide 4'-kinase activity
AhyD4_RS07980	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AhyD4_RS07985	COG2197	response regulator
AhyD4_RS07990	COG0322	excinuclease ABC activity
AhyD4_RS08015	COG0582	viral genome integration into host DNA
AhyD4_RS08040	COG4372	Transposase
AhyD4_RS08060	COG3962	Belongs to the TPP enzyme family
AhyD4_RS08065	COG0673	inositol 2-dehydrogenase activity
AhyD4_RS08070	COG1879	ABC-type sugar transport system periplasmic component
AhyD4_RS08080	COG1172	Belongs to the binding-protein-dependent transport system permease family
AhyD4_RS08085	COG0673	inositol 2-dehydrogenase activity
AhyD4_RS08090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AhyD4_RS08100	COG3718	enzyme involved in inositol metabolism
AhyD4_RS08105	COG3039	Transposase
AhyD4_RS08180	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AhyD4_RS08185	COG0437	4 iron, 4 sulfur cluster binding
AhyD4_RS08190	COG3301	Polysulphide reductase, NrfD
AhyD4_RS08195	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AhyD4_RS08205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AhyD4_RS08210	COG0215	cysteine-tRNA ligase activity
AhyD4_RS08225	COG2199	diguanylate cyclase activity
AhyD4_RS08225	COG2203	Gaf domain
AhyD4_RS08255	COG2119	membrane
AhyD4_RS08260	COG0023	Translation Initiation Factor
AhyD4_RS08285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AhyD4_RS08300	COG2205	protein histidine kinase activity
AhyD4_RS08300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AhyD4_RS08310	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AhyD4_RS08320	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AhyD4_RS08325	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AhyD4_RS08330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AhyD4_RS08335	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AhyD4_RS08340	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AhyD4_RS08345	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AhyD4_RS08355	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AhyD4_RS08360	COG0505	Belongs to the CarA family
AhyD4_RS08365	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AhyD4_RS08370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AhyD4_RS08400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AhyD4_RS08405	COG0513	Belongs to the DEAD box helicase family
AhyD4_RS08415	COG4104	PAAR repeat-containing protein
AhyD4_RS08430	COG0789	Transcriptional regulator
AhyD4_RS08445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AhyD4_RS08450	COG0765	amino acid transport
AhyD4_RS08455	COG1126	abc transporter atp-binding protein
AhyD4_RS08460	COG0493	'glutamate synthase
AhyD4_RS08465	COG0067	glutamate synthase
AhyD4_RS08465	COG0069	glutamate synthase activity
AhyD4_RS08465	COG0070	glutamate synthase
AhyD4_RS08470	COG1242	4 iron, 4 sulfur cluster binding
AhyD4_RS08535	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AhyD4_RS08540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AhyD4_RS08540	COG0574	Belongs to the PEP-utilizing enzyme family
AhyD4_RS08585	COG1464	Belongs to the NlpA lipoprotein family
AhyD4_RS08590	COG0671	phosphoesterase, PA-phosphatase related
AhyD4_RS08595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AhyD4_RS08600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AhyD4_RS08610	COG0101	tRNA pseudouridine synthase activity
AhyD4_RS08615	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AhyD4_RS08620	COG0285	dihydrofolate synthase activity
AhyD4_RS08625	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AhyD4_RS08630	COG2920	part of a sulfur-relay system
AhyD4_RS08635	COG1289	transmembrane transporter activity
AhyD4_RS08640	COG0670	Belongs to the BI1 family
AhyD4_RS08660	COG2194	sulfuric ester hydrolase activity
AhyD4_RS08670	COG0392	lysyltransferase activity
AhyD4_RS08670	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AhyD4_RS08680	COG0840	transmembrane signaling receptor activity
AhyD4_RS08685	COG5001	Diguanylate cyclase
AhyD4_RS08690	COG0564	pseudouridine synthase activity
AhyD4_RS08705	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AhyD4_RS08715	COG0625	glutathione transferase activity
AhyD4_RS08720	COG0625	glutathione transferase activity
AhyD4_RS08730	COG0367	asparagine synthase
AhyD4_RS08740	COG4651	solute:proton antiporter activity
AhyD4_RS08740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AhyD4_RS08745	COG0647	UMP catabolic process
AhyD4_RS08750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AhyD4_RS08755	COG1902	pentaerythritol trinitrate reductase activity
AhyD4_RS08760	COG1253	flavin adenine dinucleotide binding
AhyD4_RS08770	COG0277	FAD linked oxidase domain protein
AhyD4_RS08770	COG0247	lactate metabolic process
AhyD4_RS08780	COG2050	protein possibly involved in aromatic compounds catabolism
AhyD4_RS08790	COG2056	Na+-H+ antiporter family
AhyD4_RS08795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AhyD4_RS08810	COG0346	lactoylglutathione lyase activity
AhyD4_RS08815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AhyD4_RS08820	COG4660	Part of a membrane complex involved in electron transport
AhyD4_RS08825	COG4659	FMN binding
AhyD4_RS08830	COG4658	electron transport chain
AhyD4_RS08840	COG2878	Part of a membrane complex involved in electron transport
AhyD4_RS08845	COG4657	Part of a membrane complex involved in electron transport
AhyD4_RS08850	COG0697	spore germination
AhyD4_RS08865	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AhyD4_RS08870	COG1288	antiporter activity
AhyD4_RS08875	COG0436	Aminotransferase
AhyD4_RS08885	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AhyD4_RS08890	COG2027	D-alanyl-D-alanine carboxypeptidase
AhyD4_RS08895	COG1061	Type III restriction enzyme res subunit
AhyD4_RS08900	COG1566	PFAM secretion protein HlyD family protein
AhyD4_RS08910	COG1966	Carbon starvation protein
AhyD4_RS08915	COG3279	Response regulator of the LytR AlgR family
AhyD4_RS08920	COG3275	phosphorelay sensor kinase activity
AhyD4_RS08925	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AhyD4_RS08925	COG2199	diguanylate cyclase activity
AhyD4_RS08930	COG1012	belongs to the aldehyde dehydrogenase family
AhyD4_RS08930	COG1454	alcohol dehydrogenase
AhyD4_RS08940	COG2095	MarC family integral membrane protein
AhyD4_RS08950	COG0601	transmembrane transport
AhyD4_RS08955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AhyD4_RS08975	COG0861	Integral membrane protein TerC family
AhyD4_RS08980	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AhyD4_RS08990	COG1301	dicarboxylic acid transport
AhyD4_RS09005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AhyD4_RS09020	COG0537	adenosine 5'-monophosphoramidase activity
AhyD4_RS09055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AhyD4_RS09060	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AhyD4_RS09070	COG2354	Protein conserved in bacteria
AhyD4_RS09085	COG2233	PERMEase
AhyD4_RS09090	COG3150	esterase
AhyD4_RS09095	COG1252	NADH dehydrogenase
AhyD4_RS09115	COG0393	Putative heavy-metal-binding
AhyD4_RS09125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AhyD4_RS09125	COG1648	precorrin-2 dehydrogenase activity
AhyD4_RS09145	COG4667	esterase of the alpha-beta hydrolase superfamily
AhyD4_RS09150	COG1619	proteins homologs of microcin C7 resistance protein MccF
AhyD4_RS09155	COG1368	sulfuric ester hydrolase activity
AhyD4_RS09165	COG0527	aspartate kinase activity
AhyD4_RS09170	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AhyD4_RS09170	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AhyD4_RS09175	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AhyD4_RS09200	COG0596	Alpha beta hydrolase
AhyD4_RS09205	COG0346	lactoylglutathione lyase activity
AhyD4_RS09215	COG0583	DNA-binding transcription factor activity
AhyD4_RS09220	COG1620	l-lactate permease
AhyD4_RS09230	COG1139	Iron-sulfur cluster binding protein
AhyD4_RS09250	COG0577	efflux transmembrane transporter activity
AhyD4_RS09255	COG1136	(ABC) transporter
AhyD4_RS09265	COG2814	Major facilitator Superfamily
AhyD4_RS09285	COG0672	)-iron permease
AhyD4_RS09315	COG0659	secondary active sulfate transmembrane transporter activity
AhyD4_RS09385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AhyD4_RS09390	COG0840	transmembrane signaling receptor activity
AhyD4_RS09400	COG2201	protein-glutamate methylesterase activity
AhyD4_RS09410	COG0835	chemotaxis
AhyD4_RS09415	COG0840	transmembrane signaling receptor activity
AhyD4_RS09415	COG3290	protein histidine kinase activity
AhyD4_RS09420	COG0643	Histidine kinase
AhyD4_RS09420	COG2198	Histidine kinase
AhyD4_RS09430	COG0745	RESPONSE REGULATOR receiver
AhyD4_RS09435	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AhyD4_RS09440	COG0437	4 iron, 4 sulfur cluster binding
AhyD4_RS09445	COG5557	Pfam Polysulphide reductase, NrfD
AhyD4_RS09450	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AhyD4_RS09455	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AhyD4_RS09460	COG1773	rubredoxin
AhyD4_RS09465	COG0747	negative chemotaxis
AhyD4_RS09470	COG0601	transmembrane transport
AhyD4_RS09475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AhyD4_RS09480	COG0444	Belongs to the ABC transporter superfamily
AhyD4_RS09485	COG3842	ATPase activity
AhyD4_RS09490	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AhyD4_RS09495	COG0375	protein maturation
AhyD4_RS09500	COG0309	Hydrogenase expression formation protein (HypE)
AhyD4_RS09510	COG0298	carbon dioxide binding
AhyD4_RS09515	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AhyD4_RS09525	COG1921	L-seryl-tRNASec selenium transferase activity
AhyD4_RS09530	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AhyD4_RS09540	COG3260	NADH ubiquinone oxidoreductase 20
AhyD4_RS09545	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AhyD4_RS09550	COG3261	NADH dehydrogenase
AhyD4_RS09550	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
AhyD4_RS09555	COG0650	Formate hydrogenlyase subunit 4
AhyD4_RS09560	COG0651	ATP synthesis coupled electron transport
AhyD4_RS09565	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AhyD4_RS09570	COG3158	transport of potassium into the cell
AhyD4_RS09575	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AhyD4_RS09580	COG3383	formate dehydrogenase (NAD+) activity
AhyD4_RS09585	COG3383	formate dehydrogenase (NAD+) activity
AhyD4_RS09605	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AhyD4_RS09610	COG0326	Molecular chaperone. Has ATPase activity
AhyD4_RS09615	COG0563	adenylate kinase activity
AhyD4_RS09620	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AhyD4_RS09630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AhyD4_RS09650	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AhyD4_RS09670	COG1021	2,3-dihydroxybenzoate-AMP ligase
AhyD4_RS09675	COG1535	isochorismatase
AhyD4_RS09675	COG3433	isochorismatase activity
AhyD4_RS09680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AhyD4_RS09685	COG1028	Short-chain dehydrogenase reductase Sdr
AhyD4_RS09695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AhyD4_RS09700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AhyD4_RS09705	COG2977	Belongs to the P-Pant transferase superfamily
AhyD4_RS09710	COG1120	ATPase activity
AhyD4_RS09715	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AhyD4_RS09720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AhyD4_RS09725	COG4771	TonB-dependent receptor
AhyD4_RS09765	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AhyD4_RS09770	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AhyD4_RS09775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AhyD4_RS09790	COG1570	exodeoxyribonuclease VII activity
AhyD4_RS09795	COG0697	spore germination
AhyD4_RS09815	COG3158	transport of potassium into the cell
AhyD4_RS09820	COG0516	GMP reductase activity
AhyD4_RS09820	COG0517	IMP dehydrogenase activity
AhyD4_RS09825	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AhyD4_RS09825	COG0519	Catalyzes the synthesis of GMP from XMP
AhyD4_RS09830	COG0582	viral genome integration into host DNA
AhyD4_RS09880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AhyD4_RS09880	COG2169	Transcriptional regulator
AhyD4_RS09905	COG2062	phosphohistidine phosphatase, SixA
AhyD4_RS09915	COG0697	spore germination
AhyD4_RS09920	COG4166	transmembrane transport
AhyD4_RS09925	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AhyD4_RS09930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AhyD4_RS09940	COG4591	ABC-type transport system involved in lipoprotein release permease component
AhyD4_RS09945	COG1136	(ABC) transporter
AhyD4_RS09950	COG4591	ABC-type transport system involved in lipoprotein release permease component
AhyD4_RS09955	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AhyD4_RS09965	COG0544	peptidyl-prolyl cis-trans isomerase activity
AhyD4_RS09970	COG0740	serine-type endopeptidase activity
AhyD4_RS09975	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AhyD4_RS09980	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AhyD4_RS09990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AhyD4_RS09995	COG0488	(ABC) transporter
AhyD4_RS10000	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AhyD4_RS10005	COG3162	membrane
AhyD4_RS10020	COG1024	Enoyl-CoA hydratase
AhyD4_RS10055	COG1115	amino acid carrier protein
AhyD4_RS10070	COG1584	GPR1 FUN34 yaaH family protein
AhyD4_RS10105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AhyD4_RS10110	COG1960	acyl-CoA dehydrogenase activity
AhyD4_RS10120	COG1960	acyl-CoA dehydrogenase activity
AhyD4_RS10125	COG1024	Enoyl-CoA hydratase
AhyD4_RS10130	COG1024	Enoyl-CoA hydratase
AhyD4_RS10140	COG1028	Short-chain dehydrogenase reductase Sdr
AhyD4_RS10150	COG0730	response to heat
AhyD4_RS10185	COG2003	Belongs to the UPF0758 family
AhyD4_RS10195	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AhyD4_RS10215	COG1073	alpha beta
AhyD4_RS10220	COG1506	peptidase
AhyD4_RS10220	COG0823	Involved in the tonB-independent uptake of proteins
AhyD4_RS10225	COG0702	epimerase
AhyD4_RS10230	COG0583	DNA-binding transcription factor activity
AhyD4_RS10235	COG0667	Aldo Keto reductase
AhyD4_RS10250	COG3706	GGDEF domain
AhyD4_RS10255	COG0583	DNA-binding transcription factor activity
AhyD4_RS10260	COG2723	6-phospho-beta-galactosidase activity
AhyD4_RS10265	COG5001	Diguanylate cyclase
AhyD4_RS10265	COG3300	MHYT domain
AhyD4_RS10275	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AhyD4_RS10280	COG1028	Short-chain dehydrogenase reductase Sdr
AhyD4_RS10285	COG0583	DNA-binding transcription factor activity
AhyD4_RS10290	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AhyD4_RS10295	COG0673	inositol 2-dehydrogenase activity
AhyD4_RS10300	COG0583	DNA-binding transcription factor activity
AhyD4_RS10310	COG1560	Kdo2-lipid A biosynthetic process
AhyD4_RS10315	COG1560	Kdo2-lipid A biosynthetic process
AhyD4_RS10340	COG0417	DNA replication proofreading
AhyD4_RS10370	COG0534	Mate efflux family protein
AhyD4_RS10380	COG0307	riboflavin synthase, alpha
AhyD4_RS10390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AhyD4_RS10395	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AhyD4_RS10400	COG0697	spore germination
AhyD4_RS10405	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AhyD4_RS10445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AhyD4_RS10450	COG3099	Belongs to the UPF0263 family
AhyD4_RS10455	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AhyD4_RS10460	COG2894	cell division
AhyD4_RS10465	COG0850	regulation of cytokinetic process
AhyD4_RS10470	COG3100	YcgL domain-containing protein
AhyD4_RS10475	COG2951	lytic endotransglycosylase activity
AhyD4_RS10480	COG1760	l-serine dehydratase
AhyD4_RS10485	COG1760	l-serine dehydratase
AhyD4_RS10490	COG3123	guanosine phosphorylase activity
AhyD4_RS10510	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AhyD4_RS10530	COG1595	DNA-templated transcription, initiation
AhyD4_RS10560	COG0714	Associated with various cellular activities
AhyD4_RS10565	COG0183	Belongs to the thiolase family
AhyD4_RS10570	COG1024	Enoyl-CoA hydratase
AhyD4_RS10570	COG1250	3-hydroxyacyl-CoA dehydrogenase
AhyD4_RS10595	COG4388	Caudovirus prohead serine protease
AhyD4_RS10600	COG3829	transcription factor binding
AhyD4_RS10605	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AhyD4_RS10610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AhyD4_RS10615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AhyD4_RS10625	COG0549	Belongs to the carbamate kinase family
AhyD4_RS10630	COG0697	spore germination
AhyD4_RS10635	COG3608	succinylglutamate desuccinylase aspartoacylase
AhyD4_RS10635	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AhyD4_RS10640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AhyD4_RS10650	COG0493	'glutamate synthase
AhyD4_RS10650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AhyD4_RS10655	COG0402	S-adenosylhomocysteine deaminase activity
AhyD4_RS10660	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AhyD4_RS10665	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AhyD4_RS10665	COG2080	2 iron, 2 sulfur cluster binding
AhyD4_RS10670	COG2233	PERMEase
AhyD4_RS10675	COG0402	S-adenosylhomocysteine deaminase activity
AhyD4_RS10680	COG2252	PERMEase
AhyD4_RS10685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AhyD4_RS10690	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AhyD4_RS10695	COG2080	2 iron, 2 sulfur cluster binding
AhyD4_RS10705	COG3134	Outer membrane lipoprotein
AhyD4_RS10715	COG1288	antiporter activity
AhyD4_RS10720	COG0318	PFAM AMP-dependent synthetase and ligase
AhyD4_RS10725	COG0140	phosphoribosyl-ATP diphosphatase activity
AhyD4_RS10725	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AhyD4_RS10730	COG0107	imidazoleglycerol-phosphate synthase activity
AhyD4_RS10735	COG2205	protein histidine kinase activity
AhyD4_RS10735	COG0784	Response regulator, receiver
AhyD4_RS10735	COG2198	Histidine kinase
AhyD4_RS10740	COG2199	diguanylate cyclase activity
AhyD4_RS10745	COG3437	response regulator, receiver
AhyD4_RS10750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AhyD4_RS10755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AhyD4_RS10760	COG0131	Imidazoleglycerol-phosphate dehydratase
AhyD4_RS10760	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AhyD4_RS10765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AhyD4_RS10770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AhyD4_RS10775	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AhyD4_RS10785	COG1199	ATP-dependent helicase activity
AhyD4_RS10790	COG1214	PFAM Peptidase M22, glycoprotease
AhyD4_RS10800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AhyD4_RS10800	COG2226	methyltransferase
AhyD4_RS10800	COG0596	Alpha beta hydrolase
AhyD4_RS10805	COG0318	PFAM AMP-dependent synthetase and ligase
AhyD4_RS10810	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AhyD4_RS10930	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AhyD4_RS10940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AhyD4_RS10945	COG2832	Protein of unknown function (DUF454)
AhyD4_RS10950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AhyD4_RS10960	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AhyD4_RS10965	COG0582	viral genome integration into host DNA
AhyD4_RS10995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AhyD4_RS11090	COG0753	catalase activity
AhyD4_RS11115	COG3646	Phage regulatory protein
AhyD4_RS11115	COG3645	SOS response
AhyD4_RS11140	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AhyD4_RS11145	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AhyD4_RS11160	COG2916	Histone family protein nucleoid-structuring protein H-NS
AhyD4_RS11315	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AhyD4_RS11315	COG0517	IMP dehydrogenase activity
AhyD4_RS11315	COG0617	tRNA 3'-terminal CCA addition
AhyD4_RS11320	COG1643	Atp-dependent helicase
AhyD4_RS11330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AhyD4_RS11340	COG3437	response regulator, receiver
AhyD4_RS11345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AhyD4_RS11350	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AhyD4_RS11355	COG0709	Synthesizes selenophosphate from selenide and ATP
AhyD4_RS11375	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AhyD4_RS11380	COG0840	transmembrane signaling receptor activity
AhyD4_RS11385	COG1254	Belongs to the acylphosphatase family
AhyD4_RS11390	COG0625	glutathione transferase activity
AhyD4_RS11395	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AhyD4_RS11395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AhyD4_RS11400	COG0489	protein tyrosine kinase activity
AhyD4_RS11405	COG0572	uridine kinase
AhyD4_RS11410	COG0717	Belongs to the dCTP deaminase family
AhyD4_RS11415	COG0306	phosphate transporter
AhyD4_RS11420	COG1530	ribonuclease E activity
AhyD4_RS11425	COG0564	pseudouridine synthase activity
AhyD4_RS11435	COG0424	maF-like protein
AhyD4_RS11440	COG2814	Major facilitator Superfamily
AhyD4_RS11455	COG1399	metal-binding, possibly nucleic acid-binding protein
AhyD4_RS11460	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AhyD4_RS11465	COG0416	fatty acid biosynthetic process
AhyD4_RS11470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AhyD4_RS11480	COG1028	Short-chain dehydrogenase reductase Sdr
AhyD4_RS11485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AhyD4_RS11495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AhyD4_RS11500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AhyD4_RS11505	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AhyD4_RS11510	COG0470	DNA polymerase III
AhyD4_RS11515	COG0084	hydrolase, TatD family'
AhyD4_RS11530	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AhyD4_RS11530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AhyD4_RS11535	COG3008	intermembrane lipid transfer
AhyD4_RS11540	COG2995	paraquat-inducible protein a
AhyD4_RS11550	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AhyD4_RS11555	COG0372	Belongs to the citrate synthase family
AhyD4_RS11600	COG4221	oxidoreductase activity
AhyD4_RS11610	COG3141	response to X-ray
AhyD4_RS11620	COG1067	ATP-dependent peptidase activity
AhyD4_RS11625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AhyD4_RS11635	COG0488	(ABC) transporter
AhyD4_RS11645	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AhyD4_RS11645	COG0116	Belongs to the methyltransferase superfamily
AhyD4_RS11655	COG0167	dihydroorotate dehydrogenase activity
AhyD4_RS11660	COG2902	Dehydrogenase
AhyD4_RS11670	COG0308	aminopeptidase N
AhyD4_RS11680	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AhyD4_RS11685	COG1956	GAF domain-containing protein
AhyD4_RS11695	COG3278	Belongs to the heme-copper respiratory oxidase family
AhyD4_RS11710	COG2010	Cytochrome c
AhyD4_RS11735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AhyD4_RS11740	COG0589	response to stress
AhyD4_RS11745	COG0037	tRNA processing
AhyD4_RS11760	COG0625	glutathione transferase activity
AhyD4_RS11765	COG1869	D-ribose catabolic process
AhyD4_RS11770	COG1129	ABC transporter
AhyD4_RS11775	COG1172	Belongs to the binding-protein-dependent transport system permease family
AhyD4_RS11780	COG1879	ABC-type sugar transport system periplasmic component
AhyD4_RS11785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AhyD4_RS11790	COG1609	Transcriptional regulator
AhyD4_RS11795	COG2199	diguanylate cyclase activity
AhyD4_RS11825	COG0776	regulation of translation
AhyD4_RS11830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AhyD4_RS11830	COG0072	phenylalanine-tRNA ligase activity
AhyD4_RS11835	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AhyD4_RS11840	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AhyD4_RS11845	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AhyD4_RS11850	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AhyD4_RS11855	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AhyD4_RS11875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AhyD4_RS11885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AhyD4_RS11890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AhyD4_RS11895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AhyD4_RS11900	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AhyD4_RS11905	COG3313	Fe-S protein
AhyD4_RS11910	COG2942	2-epimerase
AhyD4_RS11915	COG3716	PTS system mannose fructose sorbose family IID component
AhyD4_RS11920	COG3715	PTS system
AhyD4_RS11925	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhyD4_RS11925	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AhyD4_RS11940	COG1609	Transcriptional regulator
AhyD4_RS11945	COG2140	Oxalate decarboxylase
AhyD4_RS11950	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AhyD4_RS11950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AhyD4_RS11950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AhyD4_RS11955	COG1105	Belongs to the carbohydrate kinase PfkB family
AhyD4_RS11960	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhyD4_RS11960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhyD4_RS11965	COG1609	Transcriptional regulator
AhyD4_RS11970	COG0814	amino acid
AhyD4_RS11980	COG5654	RES domain protein
AhyD4_RS11990	COG0513	Belongs to the DEAD box helicase family
AhyD4_RS12000	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AhyD4_RS12005	COG2890	protein-(glutamine-N5) methyltransferase activity
AhyD4_RS12010	COG2840	Smr protein MutS2
AhyD4_RS12020	COG3706	GGDEF domain
AhyD4_RS12025	COG0588	phosphoglycerate mutase activity
AhyD4_RS12050	COG2824	Alkylphosphonate utilization operon protein PhnA
AhyD4_RS12065	COG0384	phenazine biosynthesis protein PhzF
AhyD4_RS12080	COG0242	peptide deformylase activity
AhyD4_RS12100	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AhyD4_RS12105	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AhyD4_RS12115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AhyD4_RS12120	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AhyD4_RS12130	COG0205	6-phosphofructokinase activity
AhyD4_RS12135	COG1473	amidohydrolase
AhyD4_RS12140	COG1011	Hydrolase
AhyD4_RS12145	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AhyD4_RS12195	COG3593	DNA synthesis involved in DNA repair
AhyD4_RS12210	COG0583	DNA-binding transcription factor activity
AhyD4_RS12215	COG0730	response to heat
AhyD4_RS12220	COG3148	PFAM DTW domain containing protein
AhyD4_RS12230	COG1181	Belongs to the D-alanine--D-alanine ligase family
AhyD4_RS12240	COG0386	Belongs to the glutathione peroxidase family
AhyD4_RS12245	COG0513	Belongs to the DEAD box helicase family
AhyD4_RS12250	COG0456	acetyltransferase
AhyD4_RS12260	COG1742	UPF0060 membrane protein
AhyD4_RS12290	COG2329	Antibiotic biosynthesis monooxygenase
AhyD4_RS12295	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AhyD4_RS12315	COG3243	poly(R)-hydroxyalkanoic acid synthase
AhyD4_RS12325	COG2501	S4 domain
AhyD4_RS12335	COG1132	(ABC) transporter
AhyD4_RS12340	COG1132	(ABC) transporter
AhyD4_RS12350	COG3118	belongs to the thioredoxin family
AhyD4_RS12360	COG0058	SHG alpha-glucan phosphorylase activity
AhyD4_RS12395	COG0814	amino acid
AhyD4_RS12400	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AhyD4_RS12405	COG0514	ATP-dependent DNA helicase (RecQ)
AhyD4_RS12410	COG2766	serine protein kinase
AhyD4_RS12420	COG2719	SpoVR family
AhyD4_RS12425	COG2186	Transcriptional regulator
AhyD4_RS12430	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AhyD4_RS12435	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AhyD4_RS12440	COG0586	Pfam SNARE associated Golgi protein
AhyD4_RS12450	COG0556	nucleotide-excision repair
AhyD4_RS12460	COG0569	domain protein
AhyD4_RS12460	COG2985	domain, Protein
AhyD4_RS12465	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AhyD4_RS12485	COG4565	transcriptional regulatory protein
AhyD4_RS12490	COG3290	protein histidine kinase activity
AhyD4_RS12495	COG1940	carbohydrate kinase activity
AhyD4_RS12495	COG1846	Transcriptional regulator
AhyD4_RS12500	COG0840	transmembrane signaling receptor activity
AhyD4_RS12505	COG3012	SEC-C Motif Domain Protein
AhyD4_RS12510	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AhyD4_RS12515	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AhyD4_RS12520	COG0247	lactate metabolic process
AhyD4_RS12540	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AhyD4_RS12545	COG0437	4 iron, 4 sulfur cluster binding
AhyD4_RS12550	COG3301	Polysulphide reductase, NrfD
AhyD4_RS12555	COG1138	Cytochrome C-type biogenesis protein
AhyD4_RS12565	COG3088	subunit of a heme lyase
AhyD4_RS12565	COG4235	cytochrome complex assembly
AhyD4_RS12570	COG1051	belongs to the nudix hydrolase family
AhyD4_RS12580	COG3033	Beta-eliminating lyase
AhyD4_RS12585	COG3046	protein related to deoxyribodipyrimidine photolyase
AhyD4_RS12590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AhyD4_RS12615	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AhyD4_RS12620	COG0583	DNA-binding transcription factor activity
AhyD4_RS12630	COG4774	siderophore transport
AhyD4_RS12635	COG4977	sequence-specific DNA binding
AhyD4_RS12645	COG0583	DNA-binding transcription factor activity
AhyD4_RS12650	COG2910	NAD(P)H-binding
AhyD4_RS12660	COG0626	cystathionine gamma-synthase activity
AhyD4_RS12665	COG0612	Peptidase, M16
AhyD4_RS12670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AhyD4_RS12680	COG1944	ATP diphosphatase activity
AhyD4_RS12685	COG2116	formate transmembrane transporter activity
AhyD4_RS12690	COG1882	Formate acetyltransferase
AhyD4_RS12695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AhyD4_RS12705	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AhyD4_RS12715	COG1840	ABC-type Fe3 transport system, periplasmic component
AhyD4_RS12720	COG3842	ATPase activity
AhyD4_RS12730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AhyD4_RS12735	COG2983	Belongs to the UPF0260 family
AhyD4_RS12745	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AhyD4_RS12750	COG0045	succinate-CoA ligase (ADP-forming) activity
AhyD4_RS12755	COG0508	dehydrogenase complex catalyzes the overall conversion of
AhyD4_RS12760	COG0567	Dehydrogenase, E1 component
AhyD4_RS12770	COG1053	succinate dehydrogenase
AhyD4_RS12775	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AhyD4_RS12800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AhyD4_RS12805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AhyD4_RS12805	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AhyD4_RS12815	COG3069	C4-dicarboxylate transmembrane transporter activity
AhyD4_RS12830	COG1451	nucleotide metabolic process
AhyD4_RS12845	COG0254	rRNA binding
AhyD4_RS12850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AhyD4_RS12860	COG0583	DNA-binding transcription factor activity
AhyD4_RS12870	COG1172	Belongs to the binding-protein-dependent transport system permease family
AhyD4_RS12880	COG1879	ABC-type sugar transport system periplasmic component
AhyD4_RS12885	COG1069	ribulokinase activity
AhyD4_RS12895	COG2160	L-arabinose isomerase activity
AhyD4_RS12900	COG2925	Exonuclease
AhyD4_RS12910	COG3345	alpha-galactosidase
AhyD4_RS12915	COG1380	Effector of murein hydrolase LrgA
AhyD4_RS12920	COG1346	cytolysis
AhyD4_RS12925	COG0295	cytidine deaminase activity
AhyD4_RS12930	COG1022	Amp-dependent synthetase and ligase
AhyD4_RS12945	COG0861	Integral membrane protein TerC family
AhyD4_RS12950	COG2885	chlorophyll binding
AhyD4_RS12955	COG2199	diguanylate cyclase activity
AhyD4_RS12970	COG2154	pterin-4-alpha-carbinolamine dehydratase
AhyD4_RS12975	COG2154	pterin-4-alpha-carbinolamine dehydratase
AhyD4_RS12985	COG3768	UPF0283 membrane protein
AhyD4_RS12990	COG3106	COG3106 Predicted ATPase
AhyD4_RS13005	COG1842	Phage shock protein A
AhyD4_RS13010	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AhyD4_RS13020	COG4168	peptide transport system, permease
AhyD4_RS13025	COG4171	peptide transport system, permease
AhyD4_RS13035	COG4172	Belongs to the ABC transporter superfamily
AhyD4_RS13045	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AhyD4_RS13050	COG1286	toxin biosynthetic process
AhyD4_RS13055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AhyD4_RS13065	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AhyD4_RS13070	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AhyD4_RS13075	COG1674	ftsk spoiiie
AhyD4_RS13075	COG0531	amino acid
AhyD4_RS13085	COG0492	ferredoxin-NADP+ reductase activity
AhyD4_RS13090	COG3706	GGDEF domain
AhyD4_RS13095	COG3134	Outer membrane lipoprotein
AhyD4_RS13100	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AhyD4_RS13105	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AhyD4_RS13110	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AhyD4_RS13115	COG0542	response to heat
AhyD4_RS13120	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AhyD4_RS13125	COG1278	Cold shock
AhyD4_RS13130	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AhyD4_RS13160	COG3179	chitinase
AhyD4_RS13200	COG3829	transcription factor binding
AhyD4_RS13275	COG3501	Rhs element vgr protein
AhyD4_RS13305	COG1435	thymidine kinase activity
AhyD4_RS13310	COG1757	Na H antiporter
AhyD4_RS13315	COG2916	Histone family protein nucleoid-structuring protein H-NS
AhyD4_RS13320	COG2096	Adenosyltransferase
AhyD4_RS13325	COG3530	Putative quorum-sensing-regulated virulence factor
AhyD4_RS13330	COG0602	queuosine metabolic process
AhyD4_RS13335	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AhyD4_RS13355	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AhyD4_RS13365	COG0776	regulation of translation
AhyD4_RS13370	COG0539	negative regulation of cytoplasmic translation
AhyD4_RS13375	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AhyD4_RS13380	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AhyD4_RS13390	COG0583	DNA-binding transcription factor activity
AhyD4_RS13410	COG0778	Nitroreductase
AhyD4_RS13415	COG5001	Diguanylate cyclase
AhyD4_RS13415	COG3300	MHYT domain
AhyD4_RS13425	COG0583	DNA-binding transcription factor activity
AhyD4_RS13430	COG3437	response regulator, receiver
AhyD4_RS13455	COG4989	oxidoreductase activity
AhyD4_RS13460	COG0724	RNA recognition motif
AhyD4_RS13480	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AhyD4_RS13495	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AhyD4_RS13500	COG1360	Flagellar Motor Protein
AhyD4_RS13505	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AhyD4_RS13510	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AhyD4_RS13515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AhyD4_RS13515	COG0649	NAD binding
AhyD4_RS13530	COG1034	ATP synthesis coupled electron transport
AhyD4_RS13535	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AhyD4_RS13540	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AhyD4_RS13545	COG0839	Belongs to the complex I subunit 6 family
AhyD4_RS13550	COG0713	ATP synthesis coupled electron transport
AhyD4_RS13560	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AhyD4_RS13565	COG1007	ATP synthesis coupled electron transport
AhyD4_RS13575	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AhyD4_RS13575	COG0047	phosphoribosylformylglycinamidine synthase activity
AhyD4_RS13580	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AhyD4_RS13585	COG1645	bacterial-type flagellum-dependent swarming motility
AhyD4_RS13590	COG1160	GTP binding
AhyD4_RS13595	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AhyD4_RS13600	COG2976	Protein conserved in bacteria
AhyD4_RS13605	COG0124	histidyl-tRNA synthetase
AhyD4_RS13610	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AhyD4_RS13625	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AhyD4_RS13630	COG0105	UTP biosynthetic process
AhyD4_RS13635	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AhyD4_RS13645	COG0633	Ferredoxin
AhyD4_RS13650	COG0443	Heat shock 70 kDa protein
AhyD4_RS13655	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AhyD4_RS13665	COG0822	iron-sulfur transferase activity
AhyD4_RS13670	COG1104	cysteine desulfurase activity
AhyD4_RS13690	COG3154	lipid carrier protein
AhyD4_RS13695	COG0826	peptidase U32
AhyD4_RS13700	COG0826	peptidase U32
AhyD4_RS13715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AhyD4_RS13720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AhyD4_RS13725	COG1862	Preprotein translocase
AhyD4_RS13730	COG0343	queuine tRNA-ribosyltransferase activity
AhyD4_RS13735	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AhyD4_RS13740	COG0517	IMP dehydrogenase activity
AhyD4_RS13750	COG3634	alkyl hydroperoxide reductase activity
AhyD4_RS13770	COG1393	Belongs to the ArsC family
AhyD4_RS13775	COG0798	PFAM Bile acid sodium symporter
AhyD4_RS13780	COG0640	Transcriptional regulator
AhyD4_RS13785	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AhyD4_RS13785	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AhyD4_RS13790	COG0509	glycine decarboxylation via glycine cleavage system
AhyD4_RS13795	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AhyD4_RS13800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AhyD4_RS13805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AhyD4_RS13825	COG2814	Major facilitator Superfamily
AhyD4_RS13830	COG0625	glutathione transferase activity
AhyD4_RS13840	COG0483	inositol monophosphate 1-phosphatase activity
AhyD4_RS13860	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AhyD4_RS13875	COG1086	Polysaccharide biosynthesis protein
AhyD4_RS13895	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AhyD4_RS13905	COG2089	acid synthase
AhyD4_RS13975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AhyD4_RS13975	COG0301	tRNA thio-modification
AhyD4_RS13985	COG4953	penicillin-binding protein 1C
AhyD4_RS13990	COG2373	Large extracellular alpha-helical protein
AhyD4_RS14000	COG0628	permease
AhyD4_RS14005	COG1538	Outer membrane efflux protein
AhyD4_RS14025	COG0446	pyridine nucleotide-disulphide oxidoreductase
AhyD4_RS14035	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AhyD4_RS14055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AhyD4_RS14065	COG2431	L-lysine efflux transmembrane transporter activity
AhyD4_RS14070	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AhyD4_RS14075	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AhyD4_RS14090	COG1393	Belongs to the ArsC family
AhyD4_RS14100	COG4783	chaperone-mediated protein folding
AhyD4_RS14105	COG0425	Belongs to the sulfur carrier protein TusA family
AhyD4_RS14130	COG3842	ATPase activity
AhyD4_RS14135	COG3833	ABC-type maltose transport systems, permease component
AhyD4_RS14140	COG1175	transmembrane transport
AhyD4_RS14150	COG3081	Nucleoid-associated protein
AhyD4_RS14155	COG3082	Protein of unknown function (DUF1414)
AhyD4_RS14160	COG3083	sulfuric ester hydrolase activity
AhyD4_RS14165	COG4771	TonB-dependent receptor
AhyD4_RS14170	COG1770	oligopeptidase
AhyD4_RS14190	COG4574	serine-type endopeptidase inhibitor activity
AhyD4_RS14195	COG3085	chromosome segregation
AhyD4_RS14200	COG0583	DNA-binding transcription factor activity
AhyD4_RS14205	COG0287	Prephenate dehydrogenase
AhyD4_RS14205	COG1605	Chorismate mutase
AhyD4_RS14210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AhyD4_RS14215	COG0584	glycerophosphoryl diester phosphodiesterase
AhyD4_RS14225	COG1349	DNA-binding transcription factor activity
AhyD4_RS14230	COG2271	Major facilitator Superfamily
AhyD4_RS14235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AhyD4_RS14240	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AhyD4_RS14245	COG0583	DNA-binding transcription factor activity
AhyD4_RS14265	COG0656	L-ascorbic acid biosynthetic process
AhyD4_RS14270	COG2814	Major facilitator Superfamily
AhyD4_RS14280	COG1294	oxidase, subunit
AhyD4_RS14290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AhyD4_RS14300	COG2979	Protein of unknown function (DUF533)
AhyD4_RS14320	COG2271	Major facilitator Superfamily
AhyD4_RS14325	COG0583	DNA-binding transcription factor activity
AhyD4_RS14335	COG2807	transmembrane transport
AhyD4_RS14340	COG1187	pseudouridine synthase activity
AhyD4_RS14365	COG1061	Type III restriction enzyme res subunit
AhyD4_RS14375	COG2964	Protein conserved in bacteria
AhyD4_RS14380	COG3681	Belongs to the UPF0597 family
AhyD4_RS14390	COG0814	amino acid
AhyD4_RS14410	COG1166	arginine decarboxylase activity
AhyD4_RS14415	COG2195	Cleaves the N-terminal amino acid of tripeptides
AhyD4_RS14445	COG0583	DNA-binding transcription factor activity
AhyD4_RS14455	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AhyD4_RS14460	COG0840	transmembrane signaling receptor activity
AhyD4_RS14465	COG0302	gtp cyclohydrolase
AhyD4_RS14475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AhyD4_RS14480	COG2267	carboxylic ester hydrolase activity
AhyD4_RS14485	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AhyD4_RS14500	COG0314	molybdopterin synthase activity
AhyD4_RS14505	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AhyD4_RS14510	COG0315	cyclic pyranopterin monophosphate synthase activity
AhyD4_RS14515	COG0521	Mo-molybdopterin cofactor biosynthetic process
AhyD4_RS14520	COG3005	denitrification pathway
AhyD4_RS14530	COG0348	domain, Protein
AhyD4_RS14535	COG0437	4 iron, 4 sulfur cluster binding
AhyD4_RS14540	COG0243	molybdopterin cofactor binding
AhyD4_RS14550	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
AhyD4_RS14550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AhyD4_RS14555	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AhyD4_RS14560	COG3850	Histidine kinase
AhyD4_RS14565	COG2197	response regulator
AhyD4_RS14595	COG0121	glutamine amidotransferase
AhyD4_RS14600	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AhyD4_RS14605	COG1960	acyl-CoA dehydrogenase activity
AhyD4_RS14610	COG0784	Response regulator, receiver
AhyD4_RS14610	COG3437	response regulator, receiver
AhyD4_RS14625	COG0328	RNA-DNA hybrid ribonuclease activity
AhyD4_RS14630	COG2226	methyltransferase
AhyD4_RS14635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AhyD4_RS14640	COG0741	lytic transglycosylase activity
AhyD4_RS14640	COG1388	LysM domain
AhyD4_RS14645	COG3021	interspecies interaction between organisms
AhyD4_RS14655	COG1607	acyl-coa hydrolase
AhyD4_RS14670	COG0741	lytic transglycosylase activity
AhyD4_RS14680	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AhyD4_RS14705	COG0729	surface antigen
AhyD4_RS14715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AhyD4_RS14720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AhyD4_RS14730	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AhyD4_RS14740	COG4134	Bacterial extracellular solute-binding protein
AhyD4_RS14750	COG4136	ATPase activity
AhyD4_RS14755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AhyD4_RS14760	COG2951	lytic endotransglycosylase activity
AhyD4_RS14765	COG1846	Transcriptional regulator
AhyD4_RS14775	COG0033	Phosphoglucomutase
AhyD4_RS14780	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AhyD4_RS14785	COG0596	Alpha beta hydrolase
AhyD4_RS14800	COG0716	FMN binding
AhyD4_RS14810	COG0735	belongs to the Fur family
AhyD4_RS14815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AhyD4_RS14825	COG2190	(PTS) system
AhyD4_RS14825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AhyD4_RS14825	COG1263	PTS System
AhyD4_RS14830	COG0363	glucosamine-6-phosphate deaminase activity
AhyD4_RS14835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AhyD4_RS14840	COG1846	Transcriptional regulator
AhyD4_RS14840	COG1940	carbohydrate kinase activity
AhyD4_RS14845	COG2194	sulfuric ester hydrolase activity
AhyD4_RS14850	COG0217	transcriptional regulatory protein
AhyD4_RS14855	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AhyD4_RS14860	COG1801	Protein of unknown function DUF72
AhyD4_RS14865	COG4106	trans-aconitate 2-methyltransferase activity
AhyD4_RS14870	COG0500	methyltransferase
AhyD4_RS14890	COG0450	alkyl hydroperoxide reductase
AhyD4_RS14895	COG0583	DNA-binding transcription factor activity
AhyD4_RS14905	COG0791	NLP P60 protein
AhyD4_RS14920	COG1309	transcriptional regulator
AhyD4_RS14960	COG0534	Mate efflux family protein
AhyD4_RS14980	COG2366	antibiotic biosynthetic process
AhyD4_RS14985	COG0674	pyruvate-flavodoxin oxidoreductase activity
AhyD4_RS14985	COG1013	pyruvate-flavodoxin oxidoreductase activity
AhyD4_RS14985	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AhyD4_RS14985	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AhyD4_RS14995	COG3217	Mosc domain protein beta barrel domain protein
AhyD4_RS14995	COG0633	Ferredoxin
AhyD4_RS14995	COG3217	Mosc domain protein beta barrel domain protein
AhyD4_RS14995	COG0633	Ferredoxin
AhyD4_RS15005	COG0501	Belongs to the peptidase M48B family
AhyD4_RS15010	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AhyD4_RS15015	COG1073	alpha beta
AhyD4_RS15015	COG2226	methyltransferase
AhyD4_RS15020	COG0156	8-amino-7-oxononanoate synthase activity
AhyD4_RS15025	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AhyD4_RS15045	COG0017	Asparaginyl-tRNA synthetase
AhyD4_RS15050	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AhyD4_RS15065	COG3069	C4-dicarboxylate transmembrane transporter activity
AhyD4_RS15075	COG0583	DNA-binding transcription factor activity
AhyD4_RS15080	COG1393	Belongs to the ArsC family
AhyD4_RS15085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AhyD4_RS15090	COG1876	peptidase activity
AhyD4_RS15095	COG3263	regulation of cellular component size
AhyD4_RS15115	COG1280	lysine exporter protein (LysE YggA)
AhyD4_RS15140	COG1957	nucleoside hydrolase
AhyD4_RS15145	COG0564	pseudouridine synthase activity
AhyD4_RS15155	COG1454	alcohol dehydrogenase
AhyD4_RS15205	COG4964	Belongs to the GSP D family
AhyD4_RS15235	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AhyD4_RS15240	COG0702	epimerase
AhyD4_RS15245	COG2914	Belongs to the UPF0125 (RnfH) family
AhyD4_RS15250	COG2867	negative regulation of translational initiation
AhyD4_RS15255	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AhyD4_RS15345	COG4397	Mu-like prophage major head subunit gpT
AhyD4_RS15350	COG4388	Caudovirus prohead serine protease
AhyD4_RS15370	COG4383	Mu-like prophage protein gp29
AhyD4_RS15375	COG4373	Mu-like prophage FluMu protein gp28
AhyD4_RS15385	COG0640	Transcriptional regulator
AhyD4_RS15420	COG5566	PFAM Mor transcription activator
AhyD4_RS15530	COG0583	DNA-binding transcription factor activity
AhyD4_RS15535	COG2610	gluconate transmembrane transporter activity
AhyD4_RS15540	COG3048	D-serine ammonia-lyase activity
AhyD4_RS15545	COG0538	isocitrate dehydrogenase activity
AhyD4_RS15550	COG2207	Transcriptional regulator
AhyD4_RS15565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AhyD4_RS15575	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AhyD4_RS15580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AhyD4_RS15580	COG1263	PTS System
AhyD4_RS15585	COG1609	Transcriptional regulator
AhyD4_RS15600	COG0456	acetyltransferase
AhyD4_RS15620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AhyD4_RS15620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhyD4_RS15620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AhyD4_RS15630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AhyD4_RS15640	COG1187	pseudouridine synthase activity
AhyD4_RS15650	COG0482	sulfurtransferase activity
AhyD4_RS15655	COG2915	High frequency lysogenization protein hflD homolog
AhyD4_RS15660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AhyD4_RS15665	COG2850	peptidyl-arginine hydroxylation
AhyD4_RS15675	COG3153	acetyltransferase
AhyD4_RS15685	COG0625	glutathione transferase activity
AhyD4_RS15690	COG0259	pyridoxamine-phosphate oxidase activity
AhyD4_RS15705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AhyD4_RS15705	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AhyD4_RS15710	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AhyD4_RS15725	COG4235	cytochrome complex assembly
AhyD4_RS15725	COG3088	subunit of a heme lyase
AhyD4_RS15730	COG4235	cytochrome complex assembly
AhyD4_RS15730	COG3088	subunit of a heme lyase
AhyD4_RS15735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AhyD4_RS15740	COG1138	Cytochrome C-type biogenesis protein
AhyD4_RS15745	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AhyD4_RS15750	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AhyD4_RS15755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AhyD4_RS15760	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AhyD4_RS15775	COG0835	chemotaxis
AhyD4_RS15785	COG1192	Involved in chromosome partitioning
AhyD4_RS15790	COG1360	Flagellar Motor Protein
AhyD4_RS15795	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AhyD4_RS15800	COG2201	protein-glutamate methylesterase activity
AhyD4_RS15805	COG2198	Histidine kinase
AhyD4_RS15805	COG0784	Response regulator, receiver
AhyD4_RS15805	COG0643	Histidine kinase
AhyD4_RS15810	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AhyD4_RS15835	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AhyD4_RS15845	COG1684	flagellar biosynthetic protein fliR
AhyD4_RS15900	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AhyD4_RS15910	COG1677	Flagellar hook-basal body complex protein FliE
AhyD4_RS15925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AhyD4_RS15935	COG1073	alpha beta
AhyD4_RS15935	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AhyD4_RS15935	COG3064	Membrane
AhyD4_RS15950	COG2274	protein secretion by the type I secretion system
AhyD4_RS15960	COG2274	protein secretion by the type I secretion system
AhyD4_RS15980	COG1737	Transcriptional regulator
AhyD4_RS15985	COG0469	pyruvate kinase activity
AhyD4_RS15995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AhyD4_RS16000	COG1960	acyl-CoA dehydrogenase activity
AhyD4_RS16010	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AhyD4_RS16020	COG0243	molybdopterin cofactor binding
AhyD4_RS16025	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AhyD4_RS16030	COG0583	DNA-binding transcription factor activity
AhyD4_RS16065	COG1454	alcohol dehydrogenase
AhyD4_RS16065	COG1012	belongs to the aldehyde dehydrogenase family
AhyD4_RS16075	COG1012	belongs to the aldehyde dehydrogenase family
AhyD4_RS16075	COG1454	alcohol dehydrogenase
AhyD4_RS16080	COG1882	Formate acetyltransferase
AhyD4_RS16085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AhyD4_RS16095	COG4869	propanediol catabolic process
AhyD4_RS16140	COG2731	YhcH YjgK YiaL family protein
AhyD4_RS16145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AhyD4_RS16155	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AhyD4_RS16160	COG1737	Transcriptional regulator
AhyD4_RS16165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AhyD4_RS16170	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AhyD4_RS16175	COG1349	DNA-binding transcription factor activity
AhyD4_RS16180	COG0738	Major facilitator superfamily
AhyD4_RS16190	COG1070	Carbohydrate kinase
AhyD4_RS16210	COG4172	Belongs to the ABC transporter superfamily
AhyD4_RS16215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AhyD4_RS16225	COG0747	negative chemotaxis
AhyD4_RS16235	COG1388	LysM domain
AhyD4_RS16235	COG1376	ErfK ybiS ycfS ynhG family protein
AhyD4_RS16250	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AhyD4_RS16255	COG0791	NLP P60 protein
AhyD4_RS16260	COG2091	lysine biosynthetic process via aminoadipic acid
AhyD4_RS16265	COG3118	belongs to the thioredoxin family
AhyD4_RS16275	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AhyD4_RS16280	COG0788	formyltetrahydrofolate deformylase activity
AhyD4_RS16290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AhyD4_RS16310	COG0366	Alpha amylase catalytic
AhyD4_RS16315	COG0741	lytic transglycosylase activity
AhyD4_RS16315	COG0739	heme binding
AhyD4_RS16315	COG1196	nuclear chromosome segregation
AhyD4_RS16320	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AhyD4_RS16325	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AhyD4_RS16335	COG0673	inositol 2-dehydrogenase activity
AhyD4_RS16355	COG1032	radical SAM domain protein
AhyD4_RS16365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AhyD4_RS16370	COG1566	PFAM secretion protein HlyD family protein
AhyD4_RS16380	COG1752	Esterase of the alpha-beta hydrolase superfamily
AhyD4_RS16385	COG0733	neurotransmitter:sodium symporter activity
AhyD4_RS16415	COG0281	malic enzyme
AhyD4_RS16425	COG0534	Mate efflux family protein
AhyD4_RS16440	COG2233	PERMEase
AhyD4_RS16445	COG0095	Lipoate-protein ligase
AhyD4_RS16450	COG1115	amino acid carrier protein
AhyD4_RS16455	COG0019	diaminopimelate decarboxylase activity
AhyD4_RS16465	COG0678	peroxiredoxin activity
AhyD4_RS16475	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AhyD4_RS16495	COG1131	(ABC) transporter
AhyD4_RS16500	COG0545	Peptidyl-prolyl cis-trans isomerase
AhyD4_RS16505	COG3142	Participates in the control of copper homeostasis
AhyD4_RS16530	COG5002	protein histidine kinase activity
AhyD4_RS16535	COG0745	RESPONSE REGULATOR receiver
AhyD4_RS16540	COG0346	lactoylglutathione lyase activity
AhyD4_RS16545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AhyD4_RS16550	COG1960	acyl-CoA dehydrogenase activity
AhyD4_RS16555	COG3284	Transcriptional regulator
AhyD4_RS16570	COG0697	spore germination
AhyD4_RS16575	COG4565	transcriptional regulatory protein
AhyD4_RS16580	COG3290	protein histidine kinase activity
AhyD4_RS16585	COG0281	malic enzyme
AhyD4_RS16595	COG1846	Transcriptional regulator
AhyD4_RS16600	COG1566	PFAM secretion protein HlyD family protein
AhyD4_RS16625	COG0602	queuosine metabolic process
AhyD4_RS16630	COG1328	CTP reductase activity
AhyD4_RS16640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AhyD4_RS16645	COG3115	cell septum assembly
AhyD4_RS16650	COG1196	nuclear chromosome segregation
AhyD4_RS16660	COG2860	membrane
AhyD4_RS16670	COG3108	Peptidase M15
AhyD4_RS16675	COG2989	Protein conserved in bacteria
AhyD4_RS16690	COG0463	Glycosyl transferase, family 2
AhyD4_RS16705	COG0366	Alpha amylase catalytic
AhyD4_RS16740	COG3706	GGDEF domain
AhyD4_RS16745	COG0037	tRNA processing
AhyD4_RS16750	COG3590	peptidase
AhyD4_RS16760	COG0488	(ABC) transporter
AhyD4_RS16770	COG0531	amino acid
AhyD4_RS16785	COG0814	amino acid
AhyD4_RS16800	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AhyD4_RS16805	COG1982	Orn Lys Arg decarboxylase major
AhyD4_RS16810	COG0531	amino acid
AhyD4_RS16815	COG3710	Transcriptional regulator
AhyD4_RS16820	COG0825	malonyl-CoA metabolic process
AhyD4_RS16830	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AhyD4_RS16835	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AhyD4_RS16840	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AhyD4_RS16845	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AhyD4_RS16850	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AhyD4_RS16865	COG0750	zinc metalloprotease
AhyD4_RS16870	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AhyD4_RS16875	COG0575	Belongs to the CDS family
AhyD4_RS16880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AhyD4_RS16885	COG0233	cytoplasmic translational termination
AhyD4_RS16890	COG0528	UMP kinase activity
AhyD4_RS16895	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AhyD4_RS16900	COG0052	Belongs to the universal ribosomal protein uS2 family
AhyD4_RS16905	COG0024	Methionine aminopeptidase
AhyD4_RS16910	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AhyD4_RS16915	COG2171	N-acyltransferase activity
AhyD4_RS16925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AhyD4_RS16925	COG1263	PTS System
AhyD4_RS16935	COG4580	involved in the transport of maltose and maltodextrins
AhyD4_RS16945	COG0564	pseudouridine synthase activity
AhyD4_RS16950	COG3098	single-species biofilm formation
AhyD4_RS16975	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AhyD4_RS16985	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AhyD4_RS16985	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AhyD4_RS17000	COG1611	Belongs to the LOG family
AhyD4_RS17005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AhyD4_RS17010	COG0473	3-isopropylmalate dehydrogenase activity
AhyD4_RS17020	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AhyD4_RS17025	COG2363	Small membrane protein
AhyD4_RS17035	COG0583	DNA-binding transcription factor activity
AhyD4_RS17040	COG0840	transmembrane signaling receptor activity
AhyD4_RS17045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AhyD4_RS17060	COG1477	protein flavinylation
AhyD4_RS17065	COG2871	sodium ion transport
AhyD4_RS17070	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AhyD4_RS17075	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AhyD4_RS17080	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AhyD4_RS17085	COG1805	sodium ion transport
AhyD4_RS17090	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AhyD4_RS17095	COG0271	Belongs to the BolA IbaG family
AhyD4_RS17100	COG2813	Specifically methylates the guanine in position
AhyD4_RS17110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AhyD4_RS17120	COG2211	Major facilitator Superfamily
AhyD4_RS17125	COG3248	Nucleoside-binding outer membrane protein
AhyD4_RS17130	COG1666	GTP binding
AhyD4_RS17135	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AhyD4_RS17140	COG0693	protein deglycase activity
AhyD4_RS17185	COG2771	luxR family
AhyD4_RS17195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AhyD4_RS17195	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AhyD4_RS17200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AhyD4_RS17210	COG1151	hydroxylamine reductase activity
AhyD4_RS17215	COG0783	Belongs to the Dps family
AhyD4_RS17240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AhyD4_RS17255	COG4221	oxidoreductase activity
AhyD4_RS17265	COG0415	Belongs to the DNA photolyase family
AhyD4_RS17270	COG0789	Transcriptional regulator
AhyD4_RS17275	COG3272	Protein of unknown function (DUF1722)
AhyD4_RS17305	COG1605	Chorismate mutase
AhyD4_RS17305	COG0077	Prephenate dehydratase
AhyD4_RS17335	COG5377	YqaJ viral recombinase family
AhyD4_RS17380	COG2003	Belongs to the UPF0758 family
AhyD4_RS17390	COG0602	queuosine metabolic process
AhyD4_RS17395	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AhyD4_RS17430	COG0514	ATP-dependent DNA helicase (RecQ)
AhyD4_RS17435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AhyD4_RS17460	COG4771	TonB-dependent receptor
AhyD4_RS17480	COG1116	anion transmembrane transporter activity
AhyD4_RS17505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AhyD4_RS17510	COG1120	ATPase activity
AhyD4_RS17520	COG2226	methyltransferase
AhyD4_RS17525	COG3328	transposase activity
AhyD4_RS17550	COG2133	pyrroloquinoline quinone binding
AhyD4_RS17560	COG0840	transmembrane signaling receptor activity
AhyD4_RS17570	COG0300	oxidoreductase activity
AhyD4_RS17590	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AhyD4_RS17605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AhyD4_RS17610	COG0826	peptidase U32
AhyD4_RS17615	COG1280	lysine exporter protein (LysE YggA)
AhyD4_RS17625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AhyD4_RS17630	COG0840	transmembrane signaling receptor activity
AhyD4_RS17645	COG2198	Histidine kinase
AhyD4_RS17645	COG0643	Histidine kinase
AhyD4_RS17655	COG0835	chemotaxis
AhyD4_RS17660	COG0840	transmembrane signaling receptor activity
AhyD4_RS17670	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AhyD4_RS17675	COG2201	protein-glutamate methylesterase activity
AhyD4_RS17680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AhyD4_RS17710	COG2200	EAL domain
AhyD4_RS17710	COG2203	Gaf domain
AhyD4_RS17710	COG2199	diguanylate cyclase activity
AhyD4_RS17715	COG0826	peptidase U32
AhyD4_RS17720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AhyD4_RS17725	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AhyD4_RS17730	COG0305	Participates in initiation and elongation during chromosome replication
AhyD4_RS17740	COG2200	EAL domain
AhyD4_RS17745	COG0737	Belongs to the 5'-nucleotidase family
AhyD4_RS17765	COG2204	response regulator
AhyD4_RS17770	COG0545	Peptidyl-prolyl cis-trans isomerase
AhyD4_RS17785	COG1047	Peptidyl-prolyl cis-trans
AhyD4_RS17790	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AhyD4_RS17800	COG0784	Response regulator, receiver
AhyD4_RS17800	COG0835	chemotaxis
AhyD4_RS17805	COG0429	hydrolase of the alpha beta-hydrolase fold
AhyD4_RS17810	COG2203	Gaf domain
AhyD4_RS17810	COG5001	Diguanylate cyclase
AhyD4_RS17810	COG3706	GGDEF domain
AhyD4_RS17810	COG4251	negative regulation of phosphorylation
AhyD4_RS17815	COG3089	Belongs to the UPF0270 family
AhyD4_RS17825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AhyD4_RS17830	COG0463	Glycosyl transferase, family 2
AhyD4_RS17835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AhyD4_RS17835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AhyD4_RS17840	COG0726	polysaccharide deacetylase
AhyD4_RS17845	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AhyD4_RS17850	COG2076	Multidrug Resistance protein
AhyD4_RS17855	COG2076	Multidrug Resistance protein
AhyD4_RS17860	COG3954	Phosphoribulokinase
AhyD4_RS17875	COG1765	OsmC-like protein
AhyD4_RS17885	COG2226	methyltransferase
AhyD4_RS17890	COG3397	chitin binding
AhyD4_RS17905	COG2202	Pas domain
AhyD4_RS17905	COG2205	protein histidine kinase activity
AhyD4_RS17915	COG3655	Transcriptional regulator
AhyD4_RS17920	COG2814	Major facilitator Superfamily
AhyD4_RS17925	COG4771	TonB-dependent receptor
AhyD4_RS17945	COG0748	coenzyme F420 binding
AhyD4_RS17950	COG3721	Heme iron utilization protein
AhyD4_RS17960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AhyD4_RS17985	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AhyD4_RS17990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AhyD4_RS17995	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AhyD4_RS18015	COG0741	lytic transglycosylase activity
AhyD4_RS18020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AhyD4_RS18115	COG0616	signal peptide processing
AhyD4_RS18130	COG4626	Terminase
AhyD4_RS18130	COG1802	Transcriptional regulator
AhyD4_RS18180	COG0464	growth
AhyD4_RS18305	COG0582	viral genome integration into host DNA
AhyD4_RS18310	COG0488	(ABC) transporter
AhyD4_RS18320	COG2252	PERMEase
AhyD4_RS18325	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AhyD4_RS18330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AhyD4_RS18340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AhyD4_RS18350	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AhyD4_RS18355	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AhyD4_RS18360	COG2967	ApaG domain
AhyD4_RS18365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AhyD4_RS18375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AhyD4_RS18380	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AhyD4_RS18395	COG0318	PFAM AMP-dependent synthetase and ligase
AhyD4_RS18400	COG3314	Sporulation integral membrane protein YlbJ
AhyD4_RS18405	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AhyD4_RS18410	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AhyD4_RS18420	COG0142	geranyltranstransferase activity
AhyD4_RS18425	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AhyD4_RS18430	COG0330	HflC and HflK could
AhyD4_RS18435	COG0330	HflC and HflK could
AhyD4_RS18440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AhyD4_RS18445	COG1923	regulation of RNA biosynthetic process
AhyD4_RS18450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AhyD4_RS18455	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AhyD4_RS18465	COG0802	atpase or kinase
AhyD4_RS18470	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AhyD4_RS18470	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AhyD4_RS18495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AhyD4_RS18500	COG2011	ABC-type metal ion transport system permease component
AhyD4_RS18505	COG1464	Belongs to the NlpA lipoprotein family
AhyD4_RS18515	COG0840	transmembrane signaling receptor activity
AhyD4_RS18540	COG0784	Response regulator, receiver
AhyD4_RS18540	COG5002	protein histidine kinase activity
AhyD4_RS18540	COG2198	Histidine kinase
AhyD4_RS18560	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AhyD4_RS18575	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AhyD4_RS18580	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AhyD4_RS18590	COG2716	regulation of RNA biosynthetic process
AhyD4_RS18595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AhyD4_RS18600	COG3013	Belongs to the UPF0304 family
AhyD4_RS18610	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AhyD4_RS18615	COG0857	belongs to the CobB CobQ family
AhyD4_RS18615	COG0280	phosphate acetyltransferase
AhyD4_RS18625	COG0028	Belongs to the TPP enzyme family
AhyD4_RS18635	COG0671	phosphoesterase, PA-phosphatase related
AhyD4_RS18645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AhyD4_RS18650	COG0473	3-isopropylmalate dehydrogenase activity
AhyD4_RS18655	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AhyD4_RS18660	COG0066	3-isopropylmalate dehydratase activity
AhyD4_RS18680	COG1178	ABC-type Fe3 transport system permease component
AhyD4_RS18685	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AhyD4_RS18690	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AhyD4_RS18700	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AhyD4_RS18730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AhyD4_RS18735	COG0564	pseudouridine synthase activity
AhyD4_RS18745	COG3300	MHYT domain
AhyD4_RS18745	COG5001	Diguanylate cyclase
AhyD4_RS18755	COG0459	protein refolding
AhyD4_RS18760	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AhyD4_RS18765	COG0534	Mate efflux family protein
AhyD4_RS18770	COG3030	protein affecting phage T7 exclusion by the F plasmid
AhyD4_RS18775	COG1027	Aspartate ammonia-lyase
AhyD4_RS18780	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AhyD4_RS18790	COG0477	Major facilitator Superfamily
AhyD4_RS18810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AhyD4_RS18820	COG0673	inositol 2-dehydrogenase activity
AhyD4_RS18830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AhyD4_RS18835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AhyD4_RS18840	COG3036	rescue of stalled ribosome
AhyD4_RS18845	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AhyD4_RS18855	COG0138	bifunctional purine biosynthesis protein purh
AhyD4_RS18860	COG0151	Belongs to the GarS family
AhyD4_RS18890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AhyD4_RS18895	COG0358	DNA primase activity
AhyD4_RS18900	COG1610	YqeY-like protein
AhyD4_RS18905	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AhyD4_RS18920	COG1238	metal cluster binding
AhyD4_RS18925	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AhyD4_RS18930	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AhyD4_RS18935	COG0585	pseudouridine synthase activity
AhyD4_RS18945	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AhyD4_RS18950	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AhyD4_RS18955	COG0148	phosphopyruvate hydratase activity
AhyD4_RS18960	COG0504	CTP synthase activity
AhyD4_RS18965	COG3956	TIGRFAM MazG family protein
AhyD4_RS18970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AhyD4_RS18975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AhyD4_RS18985	COG4807	Protein conserved in bacteria
AhyD4_RS18990	COG3023	N-Acetylmuramoyl-L-alanine amidase
AhyD4_RS18995	COG1349	DNA-binding transcription factor activity
AhyD4_RS19005	COG2222	sugar isomerase
AhyD4_RS19010	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AhyD4_RS19020	COG3716	PTS system mannose fructose sorbose family IID component
AhyD4_RS19025	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhyD4_RS19030	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AhyD4_RS19045	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AhyD4_RS19050	COG1381	Involved in DNA repair and RecF pathway recombination
AhyD4_RS19060	COG0571	ribonuclease III activity
AhyD4_RS19065	COG0681	Belongs to the peptidase S26 family
AhyD4_RS19070	COG0481	GTPase activity
AhyD4_RS19085	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
AhyD4_RS19090	COG1595	DNA-templated transcription, initiation
AhyD4_RS19095	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AhyD4_RS19105	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AhyD4_RS19110	COG0354	folic acid binding
AhyD4_RS19145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AhyD4_RS19150	COG0191	fructose-bisphosphate aldolase activity
AhyD4_RS19155	COG0126	phosphoglycerate kinase activity
AhyD4_RS19160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AhyD4_RS19165	COG1940	carbohydrate kinase activity
AhyD4_RS19170	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AhyD4_RS19185	COG4991	sh3 domain protein
AhyD4_RS19190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AhyD4_RS19205	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AhyD4_RS19225	COG1505	serine-type exopeptidase activity
AhyD4_RS19230	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AhyD4_RS19235	COG0765	amino acid transport
AhyD4_RS19240	COG0765	amino acid transport
AhyD4_RS19245	COG1126	abc transporter atp-binding protein
AhyD4_RS19250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AhyD4_RS19255	COG1136	(ABC) transporter
AhyD4_RS19255	COG0577	efflux transmembrane transporter activity
AhyD4_RS19260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AhyD4_RS19265	COG0745	RESPONSE REGULATOR receiver
AhyD4_RS19270	COG2205	protein histidine kinase activity
AhyD4_RS19310	COG2070	2-Nitropropane dioxygenase
AhyD4_RS19335	COG1858	cytochrome C peroxidase
AhyD4_RS19340	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
AhyD4_RS19360	COG0513	Belongs to the DEAD box helicase family
AhyD4_RS19375	COG0154	amidase activity
AhyD4_RS19380	COG2957	Belongs to the agmatine deiminase family
AhyD4_RS19395	COG1902	pentaerythritol trinitrate reductase activity
AhyD4_RS19440	COG0714	Associated with various cellular activities
AhyD4_RS19450	COG0456	acetyltransferase
AhyD4_RS19460	COG1022	Amp-dependent synthetase and ligase
AhyD4_RS19470	COG2918	glutathione biosynthetic process
AhyD4_RS19475	COG0612	Peptidase, M16
AhyD4_RS19480	COG1238	metal cluster binding
AhyD4_RS19500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AhyD4_RS19505	COG0359	binds to the 23S rRNA
AhyD4_RS19510	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AhyD4_RS19515	COG0360	Binds together with S18 to 16S ribosomal RNA
AhyD4_RS19520	COG1914	H( )-stimulated, divalent metal cation uptake system
AhyD4_RS19540	COG2153	protein acetylation
AhyD4_RS19550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AhyD4_RS19555	COG0557	exoribonuclease II activity
AhyD4_RS19560	COG3706	GGDEF domain
AhyD4_RS19565	COG1854	S-ribosylhomocysteine lyase activity
AhyD4_RS19580	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AhyD4_RS19580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AhyD4_RS19640	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AhyD4_RS19645	COG1047	Peptidyl-prolyl cis-trans
AhyD4_RS19650	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AhyD4_RS19655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AhyD4_RS19660	COG0196	riboflavin kinase activity
AhyD4_RS19665	COG0728	peptidoglycan biosynthetic process
AhyD4_RS19670	COG0268	Binds directly to 16S ribosomal RNA
AhyD4_RS19675	COG0640	Transcriptional regulator
AhyD4_RS19680	COG0583	DNA-binding transcription factor activity
AhyD4_RS19690	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AhyD4_RS19695	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AhyD4_RS19700	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AhyD4_RS19710	COG1051	belongs to the nudix hydrolase family
AhyD4_RS19715	COG3066	DNA modification
AhyD4_RS19725	COG0335	large ribosomal subunit rRNA binding
AhyD4_RS19730	COG0336	Belongs to the RNA methyltransferase TrmD family
AhyD4_RS19735	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AhyD4_RS19740	COG0228	four-way junction DNA binding
AhyD4_RS19745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AhyD4_RS19750	COG4137	Cytochrome C assembly protein
AhyD4_RS19755	COG4536	flavin adenine dinucleotide binding
AhyD4_RS19765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AhyD4_RS19765	COG1017	nitric oxide dioxygenase activity
AhyD4_RS19770	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AhyD4_RS19775	COG0039	L-malate dehydrogenase activity
AhyD4_RS19780	COG4160	amino acid transport
AhyD4_RS19785	COG4215	(ABC) transporter
AhyD4_RS19790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AhyD4_RS19795	COG1126	abc transporter atp-binding protein
AhyD4_RS19800	COG1438	arginine binding
AhyD4_RS19805	COG2837	iron assimilation
AhyD4_RS19810	COG3842	ATPase activity
AhyD4_RS19820	COG1840	ABC-type Fe3 transport system, periplasmic component
AhyD4_RS19825	COG0347	Belongs to the P(II) protein family
AhyD4_RS19840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AhyD4_RS19845	COG0583	DNA-binding transcription factor activity
AhyD4_RS19860	COG1929	Belongs to the glycerate kinase type-1 family
AhyD4_RS19865	COG2610	gluconate transmembrane transporter activity
AhyD4_RS19870	COG3835	regulator
AhyD4_RS19875	COG3112	Uncharacterised protein family (UPF0231)
AhyD4_RS19890	COG0840	transmembrane signaling receptor activity
AhyD4_RS19910	COG0513	Belongs to the DEAD box helicase family
AhyD4_RS19950	COG1448	Aminotransferase
AhyD4_RS19965	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AhyD4_RS19970	COG1328	CTP reductase activity
AhyD4_RS19990	COG4946	Tricorn protease homolog
AhyD4_RS19990	COG0793	Belongs to the peptidase S41A family
AhyD4_RS20020	COG0840	transmembrane signaling receptor activity
AhyD4_RS20025	COG3397	chitin binding
AhyD4_RS20030	COG0583	DNA-binding transcription factor activity
AhyD4_RS20035	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AhyD4_RS20040	COG4208	sulfate ABC transporter
AhyD4_RS20045	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AhyD4_RS20055	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AhyD4_RS20060	COG3174	membrane
AhyD4_RS20065	COG0110	maltose O-acetyltransferase activity
AhyD4_RS20090	COG0165	Argininosuccinate lyase
AhyD4_RS20095	COG0137	argininosuccinate synthase activity
AhyD4_RS20105	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AhyD4_RS20110	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AhyD4_RS20120	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AhyD4_RS20130	COG0527	aspartate kinase activity
AhyD4_RS20130	COG0460	homoserine dehydrogenase
AhyD4_RS20135	COG0626	cystathionine gamma-synthase activity
AhyD4_RS20145	COG2207	Transcriptional regulator
AhyD4_RS20145	COG3708	Transcriptional regulator
AhyD4_RS20150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AhyD4_RS20155	COG0814	amino acid
AhyD4_RS20160	COG1218	3'(2'),5'-bisphosphate nucleotidase
AhyD4_RS20165	COG0494	nUDIX hydrolase
AhyD4_RS20170	COG1011	Hydrolase
AhyD4_RS20175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AhyD4_RS20190	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AhyD4_RS20200	COG3156	type II secretion system protein K
AhyD4_RS20205	COG4795	General secretion pathway protein
AhyD4_RS20210	COG2165	general secretion pathway protein
AhyD4_RS20220	COG2165	general secretion pathway protein
AhyD4_RS20225	COG1459	type II secretion system
AhyD4_RS20230	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AhyD4_RS20240	COG3031	protein transport across the cell outer membrane
AhyD4_RS20250	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AhyD4_RS20255	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AhyD4_RS20275	COG0456	acetyltransferase
AhyD4_RS20280	COG3133	Outer membrane lipoprotein
AhyD4_RS20295	COG2771	luxR family
AhyD4_RS20300	COG3916	Acyl-homoserine-lactone synthase
AhyD4_RS20310	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AhyD4_RS20315	COG1309	transcriptional regulator
AhyD4_RS20325	COG2213	PTS system mannitol-specific
AhyD4_RS20325	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhyD4_RS20330	COG0246	Mannitol dehydrogenase
AhyD4_RS20335	COG3722	fumarate hydratase activity
AhyD4_RS20340	COG3263	regulation of cellular component size
AhyD4_RS20365	COG1671	Belongs to the UPF0178 family
AhyD4_RS20380	COG1988	membrane-bound metal-dependent
AhyD4_RS20385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AhyD4_RS20390	COG0513	Belongs to the DEAD box helicase family
AhyD4_RS20415	COG1575	Belongs to the MenA family. Type 1 subfamily
AhyD4_RS20420	COG1169	isochorismate synthase
AhyD4_RS20425	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AhyD4_RS20430	COG0596	Alpha beta hydrolase
AhyD4_RS20435	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AhyD4_RS20440	COG1441	menaquinone biosynthetic process
AhyD4_RS20445	COG0318	PFAM AMP-dependent synthetase and ligase
AhyD4_RS20460	COG3539	Fimbrial protein
AhyD4_RS20465	COG3121	Chaperone
AhyD4_RS20470	COG3188	usher protein
AhyD4_RS20480	COG3539	Fimbrial protein
AhyD4_RS20490	COG3291	Pkd domain containing protein
AhyD4_RS20495	COG2949	membrane
AhyD4_RS20500	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AhyD4_RS20510	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AhyD4_RS20515	COG5380	lipid catabolic process
AhyD4_RS20530	COG4533	DNA binding
AhyD4_RS20535	COG2873	o-acetylhomoserine
AhyD4_RS20545	COG1979	alcohol dehydrogenase
AhyD4_RS20565	COG4221	oxidoreductase activity
AhyD4_RS20585	COG1285	pathogenesis
AhyD4_RS20605	COG1368	sulfuric ester hydrolase activity
AhyD4_RS20610	COG1522	sequence-specific DNA binding
AhyD4_RS20620	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AhyD4_RS20625	COG1418	mRNA catabolic process
AhyD4_RS20630	COG1058	Belongs to the CinA family
AhyD4_RS20630	COG1546	Belongs to the CinA family
AhyD4_RS20645	COG1129	ABC transporter
AhyD4_RS20645	COG0842	Transport permease protein
AhyD4_RS20660	COG0561	phosphatase activity
AhyD4_RS20665	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AhyD4_RS20685	COG1011	Hydrolase
AhyD4_RS20700	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AhyD4_RS20705	COG0019	diaminopimelate decarboxylase activity
AhyD4_RS20710	COG1965	Belongs to the frataxin family
AhyD4_RS20715	COG0400	carboxylic ester hydrolase activity
AhyD4_RS20720	COG3072	Adenylate cyclase
AhyD4_RS20725	COG0181	hydroxymethylbilane synthase activity
AhyD4_RS20735	COG2959	enzyme of heme biosynthesis
AhyD4_RS20750	COG1494	fructose-1,6-bisphosphatase
AhyD4_RS20790	COG1733	regulation of RNA biosynthetic process
AhyD4_RS20810	COG3932	Exopolysaccharide synthesis, ExoD
AhyD4_RS20815	COG0814	amino acid
AhyD4_RS20820	COG3706	GGDEF domain
AhyD4_RS20835	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
AhyD4_RS20845	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AhyD4_RS20850	COG2022	thiamine diphosphate biosynthetic process
AhyD4_RS20860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AhyD4_RS20865	COG0352	thiamine-phosphate diphosphorylase activity
AhyD4_RS20870	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AhyD4_RS20890	COG0745	RESPONSE REGULATOR receiver
AhyD4_RS20895	COG0642	Histidine kinase
AhyD4_RS20905	COG0189	ligase activity
AhyD4_RS20945	COG3171	Protein conserved in bacteria
AhyD4_RS20960	COG3188	usher protein
AhyD4_RS21010	COG1639	'signal transduction protein
AhyD4_RS21020	COG2321	neutral zinc metallopeptidase
AhyD4_RS21025	COG3700	Belongs to the class B bacterial acid phosphatase family
AhyD4_RS21045	COG1366	Belongs to the anti-sigma-factor antagonist family
AhyD4_RS21050	COG2172	sigma factor antagonist activity
AhyD4_RS21055	COG2205	protein histidine kinase activity
AhyD4_RS21055	COG0784	Response regulator, receiver
AhyD4_RS21055	COG5002	protein histidine kinase activity
AhyD4_RS21060	COG3437	response regulator, receiver
AhyD4_RS21070	COG0477	Major facilitator Superfamily
AhyD4_RS21085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AhyD4_RS21090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AhyD4_RS21090	COG1263	PTS System
AhyD4_RS21110	COG0312	modulator of DNA gyrase
AhyD4_RS21115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AhyD4_RS21125	COG3164	Protein of unknown function
AhyD4_RS21130	COG1530	ribonuclease E activity
AhyD4_RS21135	COG0424	maF-like protein
AhyD4_RS21140	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AhyD4_RS21145	COG1792	Involved in formation and maintenance of cell shape
AhyD4_RS21150	COG1077	Cell shape determining protein MreB Mrl
AhyD4_RS21175	COG4968	Prepilin-type N-terminal cleavage methylation domain
AhyD4_RS21180	COG4969	Belongs to the N-Me-Phe pilin family
AhyD4_RS21185	COG2165	general secretion pathway protein
AhyD4_RS21195	COG1459	type II secretion system
AhyD4_RS21200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AhyD4_RS21210	COG2842	Transposition protein
AhyD4_RS21245	COG2200	EAL domain
AhyD4_RS21245	COG2199	diguanylate cyclase activity
AhyD4_RS21250	COG2200	EAL domain
AhyD4_RS21255	COG0387	Pfam Sodium calcium exchanger
AhyD4_RS21260	COG2986	histidine ammonia-lyase
AhyD4_RS21265	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AhyD4_RS21270	COG0010	Belongs to the arginase family
AhyD4_RS21275	COG1228	amidohydrolase
AhyD4_RS21280	COG2188	Transcriptional regulator
AhyD4_RS21285	COG0288	reversible hydration of carbon dioxide
AhyD4_RS21295	COG2177	Part of the ABC transporter FtsEX involved in
AhyD4_RS21300	COG2884	Cell division ATP-binding protein ftsE
AhyD4_RS21305	COG0552	protein localization to endoplasmic reticulum
AhyD4_RS21310	COG0742	ribosomal rna small subunit methyltransferase
AhyD4_RS21335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AhyD4_RS21340	COG0741	lytic transglycosylase activity
AhyD4_RS21350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AhyD4_RS21360	COG2095	MarC family integral membrane protein
AhyD4_RS21370	COG1301	dicarboxylic acid transport
AhyD4_RS21395	COG3714	YhhN family
AhyD4_RS21410	COG1770	oligopeptidase
AhyD4_RS21425	COG4221	oxidoreductase activity
AhyD4_RS21430	COG0583	DNA-binding transcription factor activity
AhyD4_RS21435	COG2249	NAD(P)H dehydrogenase (quinone) activity
AhyD4_RS21480	COG0203	ribosomal protein L17
AhyD4_RS21485	COG0202	RNA polymerase activity
AhyD4_RS21490	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AhyD4_RS21495	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AhyD4_RS21500	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AhyD4_RS21505	COG0201	protein transport
AhyD4_RS21510	COG0200	Binds to the 23S rRNA
AhyD4_RS21515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AhyD4_RS21520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AhyD4_RS21525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AhyD4_RS21530	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AhyD4_RS21535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AhyD4_RS21540	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AhyD4_RS21545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AhyD4_RS21550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AhyD4_RS21555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AhyD4_RS21560	COG0255	Belongs to the universal ribosomal protein uL29 family
AhyD4_RS21565	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AhyD4_RS21570	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AhyD4_RS21575	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AhyD4_RS21580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AhyD4_RS21585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AhyD4_RS21590	COG0089	rRNA binding
AhyD4_RS21595	COG0088	Forms part of the polypeptide exit tunnel
AhyD4_RS21600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AhyD4_RS21605	COG0051	transcription antitermination factor activity, RNA binding
AhyD4_RS21625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AhyD4_RS21630	COG2183	response to ionizing radiation
AhyD4_RS21650	COG0596	Alpha beta hydrolase
AhyD4_RS21655	COG1040	competence protein
AhyD4_RS21660	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AhyD4_RS21660	COG0316	Belongs to the HesB IscA family
AhyD4_RS21665	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AhyD4_RS21670	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AhyD4_RS21675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AhyD4_RS21680	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AhyD4_RS21685	COG4942	peptidase
AhyD4_RS21695	COG1609	Transcriptional regulator
AhyD4_RS21700	COG0800	Aldolase
AhyD4_RS21705	COG0129	dihydroxy-acid dehydratase activity
AhyD4_RS21710	COG3265	gluconokinase activity
AhyD4_RS21715	COG2610	gluconate transmembrane transporter activity
AhyD4_RS21720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AhyD4_RS21725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AhyD4_RS21735	COG0456	acetyltransferase
AhyD4_RS21745	COG1490	D-aminoacyl-tRNA deacylase activity
AhyD4_RS21750	COG1295	ribonuclease BN
AhyD4_RS21755	COG1217	gtp-binding protein TYPA
AhyD4_RS21760	COG0174	glutamine synthetase
AhyD4_RS21770	COG3852	Histidine kinase
AhyD4_RS21775	COG2204	response regulator
AhyD4_RS21780	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AhyD4_RS21785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AhyD4_RS21795	COG3078	GTPase activator activity
AhyD4_RS21810	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AhyD4_RS21820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AhyD4_RS21825	COG0408	coproporphyrinogen oxidase activity
AhyD4_RS21830	COG0009	L-threonylcarbamoyladenylate synthase
AhyD4_RS21840	COG0551	DNA topoisomerase type I activity
AhyD4_RS21845	COG2922	Belongs to the Smg family
AhyD4_RS21850	COG0758	DNA mediated transformation
AhyD4_RS21860	COG0242	peptide deformylase activity
AhyD4_RS21865	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AhyD4_RS21870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AhyD4_RS21870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AhyD4_RS21875	COG0569	domain protein
AhyD4_RS21880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AhyD4_RS21885	COG1322	Protein conserved in bacteria
AhyD4_RS21905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AhyD4_RS21910	COG0686	Belongs to the AlaDH PNT family
AhyD4_RS21915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AhyD4_RS21915	COG0519	Catalyzes the synthesis of GMP from XMP
AhyD4_RS21925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AhyD4_RS21930	COG1396	sequence-specific DNA binding
AhyD4_RS21935	COG1012	belongs to the aldehyde dehydrogenase family
AhyD4_RS21945	COG2962	Rard protein
AhyD4_RS21955	COG1280	lysine exporter protein (LysE YggA)
AhyD4_RS21965	COG2391	methyltransferase activity
AhyD4_RS21970	COG1280	lysine exporter protein (LysE YggA)
AhyD4_RS22015	COG0583	DNA-binding transcription factor activity
AhyD4_RS22020	COG1943	Transposase
AhyD4_RS22025	COG0210	DNA helicase
AhyD4_RS22030	COG1744	ABC transporter substrate-binding protein PnrA-like
AhyD4_RS22035	COG3845	ABC transporter
AhyD4_RS22040	COG4603	Belongs to the binding-protein-dependent transport system permease family
AhyD4_RS22045	COG1079	Belongs to the binding-protein-dependent transport system permease family
AhyD4_RS22050	COG0583	DNA-binding transcription factor activity
AhyD4_RS22070	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AhyD4_RS22075	COG0385	Bile acid
AhyD4_RS22080	COG0531	amino acid
AhyD4_RS22085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AhyD4_RS22090	COG0531	amino acid
AhyD4_RS22095	COG2731	YhcH YjgK YiaL family protein
AhyD4_RS22100	COG3250	beta-galactosidase activity
AhyD4_RS22105	COG1609	Transcriptional regulator
AhyD4_RS22140	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AhyD4_RS22145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AhyD4_RS22145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AhyD4_RS22150	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AhyD4_RS22155	COG3074	FtsZ-dependent cytokinesis
AhyD4_RS22165	COG1045	serine acetyltransferase
AhyD4_RS22175	COG0745	RESPONSE REGULATOR receiver
AhyD4_RS22180	COG2205	protein histidine kinase activity
AhyD4_RS22185	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AhyD4_RS22190	COG0534	Mate efflux family protein
AhyD4_RS22205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AhyD4_RS22210	COG2937	Belongs to the GPAT DAPAT family
AhyD4_RS22215	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AhyD4_RS22220	COG3161	chorismate lyase activity
AhyD4_RS22225	COG1580	Controls the rotational direction of flagella during chemotaxis
AhyD4_RS22235	COG0604	alcohol dehydrogenase
AhyD4_RS22240	COG1609	Transcriptional regulator
AhyD4_RS22260	COG1519	Transferase
AhyD4_RS22265	COG0859	PFAM glycosyl transferase family 9
AhyD4_RS22270	COG0463	Glycosyl transferase, family 2
AhyD4_RS22275	COG0859	PFAM glycosyl transferase family 9
AhyD4_RS22280	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AhyD4_RS22285	COG2990	Protein conserved in bacteria
AhyD4_RS22290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AhyD4_RS22300	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AhyD4_RS22305	COG2003	Belongs to the UPF0758 family
AhyD4_RS22310	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AhyD4_RS22315	COG0756	dUTP diphosphatase activity
AhyD4_RS22320	COG1309	transcriptional regulator
AhyD4_RS22325	COG0668	transmembrane transport
AhyD4_RS22340	COG0166	Belongs to the GPI family
AhyD4_RS22345	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AhyD4_RS22350	COG0583	DNA-binding transcription factor activity
AhyD4_RS22390	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
AhyD4_RS22395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AhyD4_RS22400	COG1739	Uncharacterized protein family UPF0029
AhyD4_RS22405	COG0006	proline dipeptidase activity
AhyD4_RS22410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AhyD4_RS22415	COG1024	Enoyl-CoA hydratase
AhyD4_RS22415	COG1250	3-hydroxyacyl-CoA dehydrogenase
AhyD4_RS22420	COG0183	Belongs to the thiolase family
AhyD4_RS22445	COG0425	Belongs to the sulfur carrier protein TusA family
AhyD4_RS22450	COG0251	oxidation-reduction process
AhyD4_RS22455	COG2885	chlorophyll binding
AhyD4_RS22460	COG1335	isochorismatase
AhyD4_RS22465	COG2818	Glycosylase
AhyD4_RS22470	COG0752	glycyl-tRNA synthetase alpha subunit
AhyD4_RS22475	COG0751	glycine-tRNA ligase activity
AhyD4_RS22490	COG0529	Catalyzes the synthesis of activated sulfate
AhyD4_RS22490	COG2046	Belongs to the sulfate adenylyltransferase family
AhyD4_RS22510	COG0814	amino acid
AhyD4_RS22515	COG0348	domain, Protein
AhyD4_RS22525	COG0446	pyridine nucleotide-disulphide oxidoreductase
AhyD4_RS22530	COG0426	domain, Protein
AhyD4_RS22530	COG1773	rubredoxin
AhyD4_RS22535	COG3604	Transcriptional regulator
AhyD4_RS22540	COG2188	Transcriptional regulator
AhyD4_RS22555	COG1609	Transcriptional regulator
AhyD4_RS22595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AhyD4_RS22620	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AhyD4_RS22635	COG3118	belongs to the thioredoxin family
AhyD4_RS22640	COG0513	Belongs to the DEAD box helicase family
AhyD4_RS22645	COG0248	Ppx GppA phosphatase
AhyD4_RS22660	COG0742	ribosomal rna small subunit methyltransferase
AhyD4_RS22680	COG0084	hydrolase, TatD family'
AhyD4_RS22685	COG0805	protein transport
AhyD4_RS22690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AhyD4_RS22700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AhyD4_RS22705	COG3165	ubiquinone biosynthetic process from chorismate
AhyD4_RS22715	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AhyD4_RS22720	COG0402	S-adenosylhomocysteine deaminase activity
AhyD4_RS22835	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AhyD4_RS22840	COG0848	biopolymer transport protein
AhyD4_RS22845	COG0811	peptide transport
AhyD4_RS22850	COG0811	peptide transport
AhyD4_RS22860	COG2771	luxR family
AhyD4_RS22865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AhyD4_RS22870	COG1349	DNA-binding transcription factor activity
AhyD4_RS22875	COG0745	RESPONSE REGULATOR receiver
AhyD4_RS22880	COG2205	protein histidine kinase activity
AhyD4_RS22890	COG4452	Inner membrane protein CreD
AhyD4_RS22895	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AhyD4_RS22900	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AhyD4_RS22905	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AhyD4_RS22910	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AhyD4_RS22915	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AhyD4_RS22920	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AhyD4_RS22925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AhyD4_RS22935	COG0356	it plays a direct role in the translocation of protons across the membrane
AhyD4_RS22945	COG1475	DNA binding
AhyD4_RS22950	COG1192	Involved in chromosome partitioning
AhyD4_RS22955	COG0357	Ribosomal RNA small subunit methyltransferase G
AhyD4_RS22960	COG0445	tRNA wobble uridine modification
AhyD4_RS22965	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AhyD4_RS22970	COG4774	siderophore transport
AhyD4_RS22975	COG4615	Cyclic peptide transporter
AhyD4_RS22980	COG1120	ATPase activity
AhyD4_RS22995	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AhyD4_RS23000	COG0706	membrane insertase activity
AhyD4_RS23005	COG0594	ribonuclease P activity
AhyD4_RS23010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AhyD4_RS23015	COG1126	abc transporter atp-binding protein
AhyD4_RS23055	COG5002	protein histidine kinase activity
AhyD4_RS23125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AhyD4_RS23195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AhyD4_RS23475	COG2003	Belongs to the UPF0758 family
AhyD4_RS23685	COG0582	viral genome integration into host DNA
AhyD4_RS23815	COG0187	DNA topoisomerase II activity
AhyD4_RS23840	COG0187	DNA topoisomerase II activity