locus-tag	class	description
I6G73_RS00020	COG1815	bacterial-type flagellum-dependent cell motility
I6G73_RS00055	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G73_RS00065	COG1677	Flagellar hook-basal body complex protein FliE
I6G73_RS00115	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6G73_RS00120	COG3107	peptidoglycan biosynthetic process
I6G73_RS00125	COG0792	nuclease activity
I6G73_RS00130	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6G73_RS00135	COG2823	Periplasmic or secreted lipoprotein
I6G73_RS00140	COG2969	positive regulation of protein catabolic process
I6G73_RS00145	COG0625	glutathione transferase activity
I6G73_RS00150	COG2857	Cytochrome c1
I6G73_RS00155	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6G73_RS00160	COG0723	plastoquinol--plastocyanin reductase activity
I6G73_RS00165	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6G73_RS00170	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6G73_RS00175	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6G73_RS00185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G73_RS00190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G73_RS00220	COG3964	amidohydrolase
I6G73_RS00235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G73_RS00235	COG3711	transcriptional antiterminator
I6G73_RS00240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G73_RS00245	COG1660	Displays ATPase and GTPase activities
I6G73_RS00250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G73_RS00260	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6G73_RS00265	COG1137	ATPase activity
I6G73_RS00270	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6G73_RS00275	COG3117	lipopolysaccharide transmembrane transporter activity
I6G73_RS00280	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6G73_RS00285	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6G73_RS00285	COG0517	IMP dehydrogenase activity
I6G73_RS00290	COG1127	ABC transporter
I6G73_RS00295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6G73_RS00300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G73_RS00305	COG2854	intermembrane phospholipid transfer
I6G73_RS00315	COG5007	Belongs to the BolA IbaG family
I6G73_RS00320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G73_RS00325	COG0312	modulator of DNA gyrase
I6G73_RS00330	COG3028	Belongs to the UPF0307 family
I6G73_RS00340	COG2926	Belongs to the UPF0265 family
I6G73_RS00370	COG1396	sequence-specific DNA binding
I6G73_RS00375	COG3135	benzoate transporter
I6G73_RS00400	COG0840	transmembrane signaling receptor activity
I6G73_RS00405	COG3047	cAMP biosynthetic process
I6G73_RS00415	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6G73_RS00420	COG2197	response regulator
I6G73_RS00425	COG0629	single-stranded DNA binding
I6G73_RS00445	COG1278	Cold shock
I6G73_RS00450	COG4771	TonB-dependent receptor
I6G73_RS00455	COG5001	Diguanylate cyclase
I6G73_RS00455	COG4251	negative regulation of phosphorylation
I6G73_RS00455	COG3706	GGDEF domain
I6G73_RS00455	COG2203	Gaf domain
I6G73_RS00505	COG0346	lactoylglutathione lyase activity
I6G73_RS00520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G73_RS00525	COG1074	ATP-dependent DNA helicase activity
I6G73_RS00530	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6G73_RS00535	COG2259	Doxx family
I6G73_RS00540	COG1741	Belongs to the pirin family
I6G73_RS00550	COG0583	DNA-binding transcription factor activity
I6G73_RS00575	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G73_RS00585	COG3842	ATPase activity
I6G73_RS00595	COG2203	Gaf domain
I6G73_RS00595	COG2199	diguanylate cyclase activity
I6G73_RS00615	COG1247	-acetyltransferase
I6G73_RS00620	COG0753	catalase activity
I6G73_RS00645	COG0494	nUDIX hydrolase
I6G73_RS00650	COG0628	permease
I6G73_RS00655	COG4221	oxidoreductase activity
I6G73_RS00660	COG2957	Belongs to the agmatine deiminase family
I6G73_RS00670	COG3284	Transcriptional regulator
I6G73_RS00685	COG1461	Dihydroxyacetone kinase
I6G73_RS00690	COG2376	Dihydroxyacetone kinase
I6G73_RS00695	COG2252	PERMEase
I6G73_RS00735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6G73_RS00740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G73_RS00745	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6G73_RS00750	COG0049	tRNA binding
I6G73_RS00755	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6G73_RS00760	COG2168	tRNA wobble position uridine thiolation
I6G73_RS00765	COG2923	Belongs to the DsrF TusC family
I6G73_RS00775	COG0251	oxidation-reduction process
I6G73_RS00780	COG2964	Protein conserved in bacteria
I6G73_RS00785	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6G73_RS00790	COG0085	RNA polymerase activity
I6G73_RS00795	COG0222	ribosome binding
I6G73_RS00800	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6G73_RS00805	COG0081	regulation of translation
I6G73_RS00810	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6G73_RS00815	COG0250	Participates in transcription elongation, termination and antitermination
I6G73_RS00830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G73_RS00855	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6G73_RS00860	COG0569	domain protein
I6G73_RS00865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G73_RS00870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G73_RS00875	COG3005	denitrification pathway
I6G73_RS00880	COG0243	molybdopterin cofactor binding
I6G73_RS00910	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6G73_RS00925	COG2204	response regulator
I6G73_RS00935	COG2205	protein histidine kinase activity
I6G73_RS00960	COG5413	integral membrane protein
I6G73_RS00970	COG1522	sequence-specific DNA binding
I6G73_RS00975	COG2502	aspartate--ammonia ligase
I6G73_RS00980	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6G73_RS00985	COG0542	response to heat
I6G73_RS00995	COG0564	pseudouridine synthase activity
I6G73_RS01000	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G73_RS01005	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G73_RS01015	COG3681	Belongs to the UPF0597 family
I6G73_RS01025	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6G73_RS01030	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6G73_RS01035	COG1979	alcohol dehydrogenase
I6G73_RS01040	COG2207	Transcriptional regulator
I6G73_RS01045	COG3040	lipid binding
I6G73_RS01075	COG0688	phosphatidylethanolamine metabolic process
I6G73_RS01095	COG0540	Belongs to the ATCase OTCase family
I6G73_RS01100	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I6G73_RS01105	COG1438	arginine binding
I6G73_RS01110	COG1288	antiporter activity
I6G73_RS01115	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6G73_RS01145	COG0840	transmembrane signaling receptor activity
I6G73_RS01165	COG3250	beta-galactosidase activity
I6G73_RS01170	COG1609	Transcriptional regulator
I6G73_RS01175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G73_RS01185	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6G73_RS01190	COG2017	converts alpha-aldose to the beta-anomer
I6G73_RS01195	COG0667	Aldo Keto reductase
I6G73_RS01200	COG1968	undecaprenyl-diphosphatase activity
I6G73_RS01205	COG3806	Anti-sigma factor
I6G73_RS01210	COG1595	DNA-templated transcription, initiation
I6G73_RS01230	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6G73_RS01235	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6G73_RS01240	COG0477	Major facilitator Superfamily
I6G73_RS01250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G73_RS01260	COG2116	formate transmembrane transporter activity
I6G73_RS01265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G73_RS01265	COG1648	precorrin-2 dehydrogenase activity
I6G73_RS01270	COG2239	Acts as a magnesium transporter
I6G73_RS01280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G73_RS01285	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6G73_RS01295	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6G73_RS01305	COG0514	ATP-dependent DNA helicase (RecQ)
I6G73_RS01310	COG2050	protein possibly involved in aromatic compounds catabolism
I6G73_RS01325	COG2258	MOSC domain
I6G73_RS01330	COG1177	transmembrane transport
I6G73_RS01335	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G73_RS01340	COG3842	ATPase activity
I6G73_RS01360	COG0174	glutamine synthetase
I6G73_RS01380	COG3045	CreA protein
I6G73_RS01385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G73_RS01390	COG0443	Heat shock 70 kDa protein
I6G73_RS01405	COG0366	Alpha amylase catalytic
I6G73_RS01410	COG1086	Polysaccharide biosynthesis protein
I6G73_RS01415	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G73_RS01445	COG1215	transferase activity, transferring glycosyl groups
I6G73_RS01455	COG1442	glycosyl transferase family 8
I6G73_RS01460	COG1215	transferase activity, transferring glycosyl groups
I6G73_RS01475	COG0318	PFAM AMP-dependent synthetase and ligase
I6G73_RS01480	COG1028	Short-chain dehydrogenase reductase Sdr
I6G73_RS01495	COG1083	cytidylyl-transferase
I6G73_RS01505	COG2089	acid synthase
I6G73_RS01525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G73_RS01530	COG0745	RESPONSE REGULATOR receiver
I6G73_RS01535	COG2205	protein histidine kinase activity
I6G73_RS01545	COG0281	malic enzyme
I6G73_RS01550	COG0702	epimerase
I6G73_RS01555	COG0254	rRNA binding
I6G73_RS01560	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G73_RS01580	COG0129	dihydroxy-acid dehydratase activity
I6G73_RS01590	COG3978	acetolactate synthase activity
I6G73_RS01600	COG0606	chelatase, subunit chli
I6G73_RS01605	COG0204	Acyl-transferase
I6G73_RS01610	COG0204	Acyl-transferase
I6G73_RS01615	COG1683	Conserved Protein
I6G73_RS01625	COG1335	isochorismatase
I6G73_RS01635	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6G73_RS01640	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6G73_RS01645	COG3639	organic phosphonate transmembrane transporter activity
I6G73_RS01650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G73_RS01655	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6G73_RS01665	COG3084	Protein conserved in bacteria
I6G73_RS01670	COG5001	Diguanylate cyclase
I6G73_RS01670	COG4251	negative regulation of phosphorylation
I6G73_RS01670	COG3706	GGDEF domain
I6G73_RS01670	COG2203	Gaf domain
I6G73_RS01675	COG0789	Transcriptional regulator
I6G73_RS01685	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6G73_RS01690	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6G73_RS01695	COG1561	YicC-like family, N-terminal region
I6G73_RS01715	COG3306	glycosyltransferase involved in LPS biosynthesis
I6G73_RS01730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G73_RS01740	COG0156	8-amino-7-oxononanoate synthase activity
I6G73_RS01745	COG1063	alcohol dehydrogenase
I6G73_RS01750	COG3245	cytochrome
I6G73_RS01760	COG0210	DNA helicase
I6G73_RS01765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G73_RS01770	COG2166	iron-sulfur cluster assembly
I6G73_RS01775	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6G73_RS01805	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6G73_RS01810	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G73_RS01815	COG1739	Uncharacterized protein family UPF0029
I6G73_RS01820	COG0006	proline dipeptidase activity
I6G73_RS01825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G73_RS01830	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G73_RS01830	COG1024	Enoyl-CoA hydratase
I6G73_RS01835	COG0183	Belongs to the thiolase family
I6G73_RS01860	COG0425	Belongs to the sulfur carrier protein TusA family
I6G73_RS01865	COG0251	oxidation-reduction process
I6G73_RS01870	COG2885	chlorophyll binding
I6G73_RS01875	COG1335	isochorismatase
I6G73_RS01880	COG2818	Glycosylase
I6G73_RS01885	COG0752	glycyl-tRNA synthetase alpha subunit
I6G73_RS01890	COG0751	glycine-tRNA ligase activity
I6G73_RS01930	COG0814	amino acid
I6G73_RS01935	COG0348	domain, Protein
I6G73_RS01945	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G73_RS01950	COG0426	domain, Protein
I6G73_RS01950	COG1773	rubredoxin
I6G73_RS01955	COG3604	Transcriptional regulator
I6G73_RS01960	COG1609	Transcriptional regulator
I6G73_RS02000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G73_RS02025	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6G73_RS02040	COG3118	belongs to the thioredoxin family
I6G73_RS02045	COG0513	Belongs to the DEAD box helicase family
I6G73_RS02050	COG0248	Ppx GppA phosphatase
I6G73_RS02065	COG0742	ribosomal rna small subunit methyltransferase
I6G73_RS02085	COG0084	hydrolase, TatD family'
I6G73_RS02090	COG0805	protein transport
I6G73_RS02095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G73_RS02105	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6G73_RS02110	COG3165	ubiquinone biosynthetic process from chorismate
I6G73_RS02120	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G73_RS02125	COG0402	S-adenosylhomocysteine deaminase activity
I6G73_RS02165	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6G73_RS02170	COG0848	biopolymer transport protein
I6G73_RS02175	COG0811	peptide transport
I6G73_RS02180	COG0811	peptide transport
I6G73_RS02190	COG2771	luxR family
I6G73_RS02195	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6G73_RS02200	COG1349	DNA-binding transcription factor activity
I6G73_RS02205	COG0745	RESPONSE REGULATOR receiver
I6G73_RS02210	COG2205	protein histidine kinase activity
I6G73_RS02220	COG4452	Inner membrane protein CreD
I6G73_RS02225	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6G73_RS02230	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6G73_RS02235	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6G73_RS02240	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6G73_RS02245	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6G73_RS02250	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6G73_RS02255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6G73_RS02265	COG0356	it plays a direct role in the translocation of protons across the membrane
I6G73_RS02275	COG1475	DNA binding
I6G73_RS02280	COG1192	Involved in chromosome partitioning
I6G73_RS02285	COG0357	Ribosomal RNA small subunit methyltransferase G
I6G73_RS02290	COG0445	tRNA wobble uridine modification
I6G73_RS02295	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6G73_RS02300	COG4774	siderophore transport
I6G73_RS02305	COG4615	Cyclic peptide transporter
I6G73_RS02310	COG1120	ATPase activity
I6G73_RS02325	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6G73_RS02330	COG0706	membrane insertase activity
I6G73_RS02335	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6G73_RS02340	COG0594	ribonuclease P activity
I6G73_RS02345	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6G73_RS02350	COG1126	abc transporter atp-binding protein
I6G73_RS02365	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G73_RS02370	COG0592	DNA-directed DNA polymerase activity
I6G73_RS02390	COG2378	regulation of single-species biofilm formation
I6G73_RS02395	COG0071	Belongs to the small heat shock protein (HSP20) family
I6G73_RS02400	COG0071	Belongs to the small heat shock protein (HSP20) family
I6G73_RS02405	COG3977	Valine--pyruvate aminotransferase
I6G73_RS02420	COG2814	Major facilitator Superfamily
I6G73_RS02425	COG0745	RESPONSE REGULATOR receiver
I6G73_RS02430	COG2205	protein histidine kinase activity
I6G73_RS02450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G73_RS02455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G73_RS02455	COG4191	Histidine kinase
I6G73_RS02460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G73_RS02465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G73_RS02470	COG1309	transcriptional regulator
I6G73_RS02500	COG0561	phosphatase activity
I6G73_RS02505	COG2267	carboxylic ester hydrolase activity
I6G73_RS02510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G73_RS02515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G73_RS02520	COG1758	RNA polymerase activity
I6G73_RS02530	COG0859	PFAM glycosyl transferase family 9
I6G73_RS02535	COG3642	lipopolysaccharide core region biosynthetic process
I6G73_RS02575	COG0589	response to stress
I6G73_RS02580	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6G73_RS02590	COG1528	Iron-storage protein
I6G73_RS02595	COG2081	HI0933 family
I6G73_RS02600	COG2223	nitrite transmembrane transporter activity
I6G73_RS02620	COG3188	usher protein
I6G73_RS02640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G73_RS02640	COG2205	protein histidine kinase activity
I6G73_RS02650	COG3275	phosphorelay sensor kinase activity
I6G73_RS02655	COG3279	Response regulator of the LytR AlgR family
I6G73_RS02660	COG2223	nitrite transmembrane transporter activity
I6G73_RS02665	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6G73_RS02670	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6G73_RS02685	COG0583	DNA-binding transcription factor activity
I6G73_RS02690	COG4206	TonB-dependent receptor
I6G73_RS02695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6G73_RS02745	COG0583	DNA-binding transcription factor activity
I6G73_RS02750	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6G73_RS02755	COG0166	Belongs to the GPI family
I6G73_RS02765	COG0668	transmembrane transport
I6G73_RS02770	COG1309	transcriptional regulator
I6G73_RS02775	COG0756	dUTP diphosphatase activity
I6G73_RS02780	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G73_RS02785	COG2003	Belongs to the UPF0758 family
I6G73_RS02790	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6G73_RS02795	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G73_RS02805	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6G73_RS02810	COG2990	Protein conserved in bacteria
I6G73_RS02815	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6G73_RS02820	COG0859	PFAM glycosyl transferase family 9
I6G73_RS02825	COG0463	Glycosyl transferase, family 2
I6G73_RS02830	COG0859	PFAM glycosyl transferase family 9
I6G73_RS02835	COG1519	Transferase
I6G73_RS02855	COG1609	Transcriptional regulator
I6G73_RS02860	COG0604	alcohol dehydrogenase
I6G73_RS02875	COG1580	Controls the rotational direction of flagella during chemotaxis
I6G73_RS02880	COG3161	chorismate lyase activity
I6G73_RS02885	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6G73_RS02890	COG2937	Belongs to the GPAT DAPAT family
I6G73_RS02895	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G73_RS02910	COG0534	Mate efflux family protein
I6G73_RS02915	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6G73_RS02920	COG2205	protein histidine kinase activity
I6G73_RS02925	COG0745	RESPONSE REGULATOR receiver
I6G73_RS02935	COG1045	serine acetyltransferase
I6G73_RS02945	COG3074	FtsZ-dependent cytokinesis
I6G73_RS02950	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6G73_RS02955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G73_RS02955	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G73_RS02960	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G73_RS02995	COG1609	Transcriptional regulator
I6G73_RS03000	COG3250	beta-galactosidase activity
I6G73_RS03005	COG2731	YhcH YjgK YiaL family protein
I6G73_RS03010	COG0531	amino acid
I6G73_RS03015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G73_RS03020	COG0531	amino acid
I6G73_RS03025	COG0385	Bile acid
I6G73_RS03030	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6G73_RS03050	COG0583	DNA-binding transcription factor activity
I6G73_RS03055	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6G73_RS03060	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6G73_RS03065	COG3845	ABC transporter
I6G73_RS03070	COG1744	ABC transporter substrate-binding protein PnrA-like
I6G73_RS03075	COG0210	DNA helicase
I6G73_RS03090	COG1943	Transposase
I6G73_RS03095	COG0583	DNA-binding transcription factor activity
I6G73_RS03150	COG1280	lysine exporter protein (LysE YggA)
I6G73_RS03155	COG2391	methyltransferase activity
I6G73_RS03165	COG1280	lysine exporter protein (LysE YggA)
I6G73_RS03175	COG2962	Rard protein
I6G73_RS03185	COG1012	belongs to the aldehyde dehydrogenase family
I6G73_RS03190	COG1396	sequence-specific DNA binding
I6G73_RS03195	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G73_RS03205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G73_RS03205	COG0519	Catalyzes the synthesis of GMP from XMP
I6G73_RS03210	COG0686	Belongs to the AlaDH PNT family
I6G73_RS03215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G73_RS03235	COG1322	Protein conserved in bacteria
I6G73_RS03240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G73_RS03245	COG0569	domain protein
I6G73_RS03250	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G73_RS03250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G73_RS03255	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6G73_RS03260	COG0242	peptide deformylase activity
I6G73_RS03270	COG0758	DNA mediated transformation
I6G73_RS03275	COG2922	Belongs to the Smg family
I6G73_RS03280	COG0551	DNA topoisomerase type I activity
I6G73_RS03290	COG0009	L-threonylcarbamoyladenylate synthase
I6G73_RS03295	COG0408	coproporphyrinogen oxidase activity
I6G73_RS03300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6G73_RS03310	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6G73_RS03320	COG3078	GTPase activator activity
I6G73_RS03330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G73_RS03335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6G73_RS03340	COG2204	response regulator
I6G73_RS03345	COG3852	Histidine kinase
I6G73_RS03355	COG0174	glutamine synthetase
I6G73_RS03360	COG1217	gtp-binding protein TYPA
I6G73_RS03365	COG1295	ribonuclease BN
I6G73_RS03370	COG1490	D-aminoacyl-tRNA deacylase activity
I6G73_RS03380	COG0456	acetyltransferase
I6G73_RS03390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6G73_RS03395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G73_RS03400	COG2610	gluconate transmembrane transporter activity
I6G73_RS03405	COG3265	gluconokinase activity
I6G73_RS03415	COG0800	Aldolase
I6G73_RS03420	COG1609	Transcriptional regulator
I6G73_RS03430	COG4942	peptidase
I6G73_RS03435	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6G73_RS03440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G73_RS03445	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6G73_RS03450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6G73_RS03455	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6G73_RS03455	COG0316	Belongs to the HesB IscA family
I6G73_RS03460	COG1040	competence protein
I6G73_RS03465	COG0596	Alpha beta hydrolase
I6G73_RS03485	COG2183	response to ionizing radiation
I6G73_RS03490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G73_RS03510	COG0051	transcription antitermination factor activity, RNA binding
I6G73_RS03515	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6G73_RS03520	COG0088	Forms part of the polypeptide exit tunnel
I6G73_RS03525	COG0089	rRNA binding
I6G73_RS03530	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6G73_RS03535	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6G73_RS03540	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6G73_RS03545	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6G73_RS03550	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6G73_RS03555	COG0255	Belongs to the universal ribosomal protein uL29 family
I6G73_RS03560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6G73_RS03565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6G73_RS03570	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6G73_RS03575	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6G73_RS03580	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6G73_RS03585	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6G73_RS03590	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6G73_RS03595	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6G73_RS03600	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6G73_RS03605	COG1841	ribosomal large subunit assembly
I6G73_RS03610	COG0200	Binds to the 23S rRNA
I6G73_RS03615	COG0201	protein transport
I6G73_RS03620	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G73_RS03625	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6G73_RS03630	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6G73_RS03635	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6G73_RS03640	COG0202	RNA polymerase activity
I6G73_RS03645	COG0203	ribosomal protein L17
I6G73_RS03700	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G73_RS03705	COG0583	DNA-binding transcription factor activity
I6G73_RS03710	COG4221	oxidoreductase activity
I6G73_RS03725	COG1770	oligopeptidase
I6G73_RS03745	COG3714	YhhN family
I6G73_RS03770	COG1301	dicarboxylic acid transport
I6G73_RS03780	COG2095	MarC family integral membrane protein
I6G73_RS03790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G73_RS03800	COG0741	lytic transglycosylase activity
I6G73_RS03810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G73_RS03835	COG0742	ribosomal rna small subunit methyltransferase
I6G73_RS03840	COG0552	protein localization to endoplasmic reticulum
I6G73_RS03845	COG2884	Cell division ATP-binding protein ftsE
I6G73_RS03850	COG2177	Part of the ABC transporter FtsEX involved in
I6G73_RS03860	COG0288	reversible hydration of carbon dioxide
I6G73_RS03865	COG2188	Transcriptional regulator
I6G73_RS03870	COG1228	amidohydrolase
I6G73_RS03875	COG0010	Belongs to the arginase family
I6G73_RS03880	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6G73_RS03885	COG2986	histidine ammonia-lyase
I6G73_RS03890	COG0387	Pfam Sodium calcium exchanger
I6G73_RS03895	COG2200	EAL domain
I6G73_RS03900	COG2200	EAL domain
I6G73_RS03900	COG2199	diguanylate cyclase activity
I6G73_RS03945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G73_RS03950	COG1459	type II secretion system
I6G73_RS03960	COG2165	general secretion pathway protein
I6G73_RS03970	COG4968	Prepilin-type N-terminal cleavage methylation domain
I6G73_RS03995	COG1077	Cell shape determining protein MreB Mrl
I6G73_RS04000	COG1792	Involved in formation and maintenance of cell shape
I6G73_RS04005	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6G73_RS04010	COG0424	maF-like protein
I6G73_RS04015	COG1530	ribonuclease E activity
I6G73_RS04020	COG3164	Protein of unknown function
I6G73_RS04030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G73_RS04035	COG0312	modulator of DNA gyrase
I6G73_RS04055	COG1263	PTS System
I6G73_RS04055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G73_RS04060	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6G73_RS04080	COG0477	Major facilitator Superfamily
I6G73_RS04090	COG3437	response regulator, receiver
I6G73_RS04095	COG2205	protein histidine kinase activity
I6G73_RS04095	COG0784	Response regulator, receiver
I6G73_RS04095	COG5002	protein histidine kinase activity
I6G73_RS04100	COG2172	sigma factor antagonist activity
I6G73_RS04105	COG1366	Belongs to the anti-sigma-factor antagonist family
I6G73_RS04125	COG3700	Belongs to the class B bacterial acid phosphatase family
I6G73_RS04130	COG2321	neutral zinc metallopeptidase
I6G73_RS04140	COG1639	'signal transduction protein
I6G73_RS04165	COG0189	ligase activity
I6G73_RS04175	COG0642	Histidine kinase
I6G73_RS04180	COG0745	RESPONSE REGULATOR receiver
I6G73_RS04200	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6G73_RS04205	COG0352	thiamine-phosphate diphosphorylase activity
I6G73_RS04210	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G73_RS04220	COG2022	thiamine diphosphate biosynthetic process
I6G73_RS04225	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6G73_RS04240	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6G73_RS04255	COG3706	GGDEF domain
I6G73_RS04260	COG0814	amino acid
I6G73_RS04265	COG3932	Exopolysaccharide synthesis, ExoD
I6G73_RS04325	COG1494	fructose-1,6-bisphosphatase
I6G73_RS04340	COG2959	enzyme of heme biosynthesis
I6G73_RS04350	COG0181	hydroxymethylbilane synthase activity
I6G73_RS04355	COG3072	Adenylate cyclase
I6G73_RS04360	COG0400	carboxylic ester hydrolase activity
I6G73_RS04365	COG1965	Belongs to the frataxin family
I6G73_RS04375	COG0019	diaminopimelate decarboxylase activity
I6G73_RS04380	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6G73_RS04395	COG1011	Hydrolase
I6G73_RS04415	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6G73_RS04420	COG0561	phosphatase activity
I6G73_RS04435	COG0842	Transport permease protein
I6G73_RS04435	COG1129	ABC transporter
I6G73_RS04445	COG1546	Belongs to the CinA family
I6G73_RS04445	COG1058	Belongs to the CinA family
I6G73_RS04450	COG1418	mRNA catabolic process
I6G73_RS04455	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6G73_RS04465	COG1522	sequence-specific DNA binding
I6G73_RS04470	COG1368	sulfuric ester hydrolase activity
I6G73_RS04490	COG1285	pathogenesis
I6G73_RS04510	COG4221	oxidoreductase activity
I6G73_RS04530	COG1979	alcohol dehydrogenase
I6G73_RS04540	COG2873	o-acetylhomoserine
I6G73_RS04550	COG4533	DNA binding
I6G73_RS04565	COG5380	lipid catabolic process
I6G73_RS04570	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6G73_RS04580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G73_RS04585	COG2949	membrane
I6G73_RS04590	COG3291	Pkd domain containing protein
I6G73_RS04600	COG3539	Fimbrial protein
I6G73_RS04610	COG3188	usher protein
I6G73_RS04615	COG3121	Chaperone
I6G73_RS04620	COG3539	Fimbrial protein
I6G73_RS04635	COG0318	PFAM AMP-dependent synthetase and ligase
I6G73_RS04640	COG1441	menaquinone biosynthetic process
I6G73_RS04645	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6G73_RS04650	COG0596	Alpha beta hydrolase
I6G73_RS04655	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6G73_RS04660	COG1169	isochorismate synthase
I6G73_RS04665	COG1575	Belongs to the MenA family. Type 1 subfamily
I6G73_RS04690	COG0513	Belongs to the DEAD box helicase family
I6G73_RS04695	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G73_RS04700	COG1988	membrane-bound metal-dependent
I6G73_RS04715	COG1671	Belongs to the UPF0178 family
I6G73_RS04740	COG3263	regulation of cellular component size
I6G73_RS04745	COG3722	fumarate hydratase activity
I6G73_RS04750	COG0246	Mannitol dehydrogenase
I6G73_RS04755	COG2213	PTS system mannitol-specific
I6G73_RS04755	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G73_RS04765	COG1309	transcriptional regulator
I6G73_RS04770	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I6G73_RS04780	COG3916	Acyl-homoserine-lactone synthase
I6G73_RS04785	COG2771	luxR family
I6G73_RS04800	COG3133	Outer membrane lipoprotein
I6G73_RS04805	COG0456	acetyltransferase
I6G73_RS04825	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6G73_RS04830	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6G73_RS04840	COG3031	protein transport across the cell outer membrane
I6G73_RS04850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G73_RS04855	COG1459	type II secretion system
I6G73_RS04860	COG2165	general secretion pathway protein
I6G73_RS04870	COG2165	general secretion pathway protein
I6G73_RS04875	COG4795	General secretion pathway protein
I6G73_RS04885	COG3156	type II secretion system protein K
I6G73_RS04895	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6G73_RS04910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6G73_RS04915	COG1011	Hydrolase
I6G73_RS04920	COG0494	nUDIX hydrolase
I6G73_RS04925	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6G73_RS04930	COG0814	amino acid
I6G73_RS04935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G73_RS04940	COG2207	Transcriptional regulator
I6G73_RS04940	COG3708	Transcriptional regulator
I6G73_RS04950	COG0626	cystathionine gamma-synthase activity
I6G73_RS04955	COG0527	aspartate kinase activity
I6G73_RS04955	COG0460	homoserine dehydrogenase
I6G73_RS04960	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6G73_RS04970	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6G73_RS04975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6G73_RS04985	COG0137	argininosuccinate synthase activity
I6G73_RS04990	COG0165	Argininosuccinate lyase
I6G73_RS05020	COG0110	maltose O-acetyltransferase activity
I6G73_RS05025	COG3174	membrane
I6G73_RS05030	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6G73_RS05040	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6G73_RS05045	COG4208	sulfate ABC transporter
I6G73_RS05050	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6G73_RS05055	COG0583	DNA-binding transcription factor activity
I6G73_RS05060	COG3397	chitin binding
I6G73_RS05065	COG0840	transmembrane signaling receptor activity
I6G73_RS05090	COG4946	Tricorn protease homolog
I6G73_RS05090	COG0793	Belongs to the peptidase S41A family
I6G73_RS05110	COG1328	CTP reductase activity
I6G73_RS05115	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G73_RS05130	COG1448	Aminotransferase
I6G73_RS05170	COG0513	Belongs to the DEAD box helicase family
I6G73_RS05190	COG0840	transmembrane signaling receptor activity
I6G73_RS05205	COG3112	Uncharacterised protein family (UPF0231)
I6G73_RS05210	COG3835	regulator
I6G73_RS05215	COG2610	gluconate transmembrane transporter activity
I6G73_RS05220	COG1929	Belongs to the glycerate kinase type-1 family
I6G73_RS05235	COG0583	DNA-binding transcription factor activity
I6G73_RS05240	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G73_RS05255	COG0347	Belongs to the P(II) protein family
I6G73_RS05260	COG1840	ABC-type Fe3 transport system, periplasmic component
I6G73_RS05270	COG3842	ATPase activity
I6G73_RS05275	COG2837	iron assimilation
I6G73_RS05280	COG1438	arginine binding
I6G73_RS05285	COG1126	abc transporter atp-binding protein
I6G73_RS05290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G73_RS05295	COG4215	(ABC) transporter
I6G73_RS05300	COG4160	amino acid transport
I6G73_RS05305	COG0039	L-malate dehydrogenase activity
I6G73_RS05310	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6G73_RS05315	COG1017	nitric oxide dioxygenase activity
I6G73_RS05315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G73_RS05325	COG4536	flavin adenine dinucleotide binding
I6G73_RS05330	COG4137	Cytochrome C assembly protein
I6G73_RS05335	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G73_RS05340	COG0228	four-way junction DNA binding
I6G73_RS05345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6G73_RS05350	COG0336	Belongs to the RNA methyltransferase TrmD family
I6G73_RS05355	COG0335	large ribosomal subunit rRNA binding
I6G73_RS05365	COG3066	DNA modification
I6G73_RS05370	COG1051	belongs to the nudix hydrolase family
I6G73_RS05380	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6G73_RS05385	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6G73_RS05390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6G73_RS05400	COG0583	DNA-binding transcription factor activity
I6G73_RS05405	COG0640	Transcriptional regulator
I6G73_RS05410	COG0268	Binds directly to 16S ribosomal RNA
I6G73_RS05415	COG0728	peptidoglycan biosynthetic process
I6G73_RS05425	COG0196	riboflavin kinase activity
I6G73_RS05430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6G73_RS05435	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6G73_RS05440	COG1047	Peptidyl-prolyl cis-trans
I6G73_RS05445	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6G73_RS05450	COG4970	Tfp pilus assembly protein FimT
I6G73_RS05505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G73_RS05505	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6G73_RS05520	COG1854	S-ribosylhomocysteine lyase activity
I6G73_RS05525	COG3706	GGDEF domain
I6G73_RS05530	COG0557	exoribonuclease II activity
I6G73_RS05535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G73_RS05545	COG2153	protein acetylation
I6G73_RS05565	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G73_RS05570	COG0360	Binds together with S18 to 16S ribosomal RNA
I6G73_RS05575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6G73_RS05580	COG0359	binds to the 23S rRNA
I6G73_RS05585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G73_RS05610	COG1238	metal cluster binding
I6G73_RS05615	COG0612	Peptidase, M16
I6G73_RS05620	COG2918	glutathione biosynthetic process
I6G73_RS05625	COG1022	Amp-dependent synthetase and ligase
I6G73_RS05635	COG0456	acetyltransferase
I6G73_RS05645	COG0714	Associated with various cellular activities
I6G73_RS05690	COG1902	pentaerythritol trinitrate reductase activity
I6G73_RS05705	COG2957	Belongs to the agmatine deiminase family
I6G73_RS05710	COG0154	amidase activity
I6G73_RS05750	COG0513	Belongs to the DEAD box helicase family
I6G73_RS05790	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
I6G73_RS05795	COG1858	cytochrome C peroxidase
I6G73_RS05820	COG2070	2-Nitropropane dioxygenase
I6G73_RS05850	COG2816	NAD+ diphosphatase activity
I6G73_RS05855	COG2205	protein histidine kinase activity
I6G73_RS05860	COG0745	RESPONSE REGULATOR receiver
I6G73_RS05865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G73_RS05870	COG1136	(ABC) transporter
I6G73_RS05870	COG0577	efflux transmembrane transporter activity
I6G73_RS05875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G73_RS05880	COG1126	abc transporter atp-binding protein
I6G73_RS05890	COG0765	amino acid transport
I6G73_RS05895	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6G73_RS05900	COG1505	serine-type exopeptidase activity
I6G73_RS05915	COG1028	Short-chain dehydrogenase reductase Sdr
I6G73_RS05920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6G73_RS05935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G73_RS05940	COG4991	sh3 domain protein
I6G73_RS05955	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6G73_RS05960	COG1940	carbohydrate kinase activity
I6G73_RS05965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G73_RS05970	COG0126	phosphoglycerate kinase activity
I6G73_RS05980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G73_RS05995	COG1324	tolerance protein
I6G73_RS06020	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6G73_RS06030	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6G73_RS06035	COG1595	DNA-templated transcription, initiation
I6G73_RS06040	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6G73_RS06055	COG0481	GTPase activity
I6G73_RS06060	COG0681	Belongs to the peptidase S26 family
I6G73_RS06065	COG0571	ribonuclease III activity
I6G73_RS06075	COG1381	Involved in DNA repair and RecF pathway recombination
I6G73_RS06080	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6G73_RS06095	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G73_RS06100	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G73_RS06105	COG3716	PTS system mannose fructose sorbose family IID component
I6G73_RS06115	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G73_RS06120	COG2222	sugar isomerase
I6G73_RS06130	COG1349	DNA-binding transcription factor activity
I6G73_RS06135	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G73_RS06140	COG4807	Protein conserved in bacteria
I6G73_RS06150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G73_RS06155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G73_RS06160	COG3956	TIGRFAM MazG family protein
I6G73_RS06165	COG0504	CTP synthase activity
I6G73_RS06170	COG0148	phosphopyruvate hydratase activity
I6G73_RS06175	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6G73_RS06180	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6G73_RS06190	COG0585	pseudouridine synthase activity
I6G73_RS06195	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6G73_RS06200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6G73_RS06205	COG1238	metal cluster binding
I6G73_RS06220	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6G73_RS06225	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6G73_RS06230	COG1610	YqeY-like protein
I6G73_RS06235	COG0358	DNA primase activity
I6G73_RS06240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G73_RS06265	COG0151	Belongs to the GarS family
I6G73_RS06270	COG0138	bifunctional purine biosynthesis protein purh
I6G73_RS06280	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6G73_RS06285	COG3036	rescue of stalled ribosome
I6G73_RS06290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G73_RS06295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6G73_RS06305	COG0673	inositol 2-dehydrogenase activity
I6G73_RS06315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G73_RS06320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G73_RS06325	COG3227	Zinc metalloprotease (Elastase)
I6G73_RS06335	COG0477	Major facilitator Superfamily
I6G73_RS06345	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6G73_RS06350	COG1027	Aspartate ammonia-lyase
I6G73_RS06355	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6G73_RS06360	COG0534	Mate efflux family protein
I6G73_RS06365	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6G73_RS06370	COG0459	protein refolding
I6G73_RS06380	COG3300	MHYT domain
I6G73_RS06380	COG5001	Diguanylate cyclase
I6G73_RS06390	COG0564	pseudouridine synthase activity
I6G73_RS06395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G73_RS06420	COG1280	lysine exporter protein (LysE YggA)
I6G73_RS06425	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6G73_RS06440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G73_RS06470	COG0745	RESPONSE REGULATOR receiver
I6G73_RS06475	COG3104	oligopeptide transport
I6G73_RS06480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G73_RS06485	COG1555	photosystem II stabilization
I6G73_RS06495	COG2350	Protein conserved in bacteria
I6G73_RS06500	COG2917	probably involved in intracellular septation
I6G73_RS06505	COG0076	glutamate decarboxylase activity
I6G73_RS06510	COG1272	protein, Hemolysin III
I6G73_RS06515	COG0569	domain protein
I6G73_RS06515	COG2985	domain, Protein
I6G73_RS06525	COG0835	chemotaxis
I6G73_RS06525	COG0784	Response regulator, receiver
I6G73_RS06530	COG2755	lipolytic protein G-D-S-L family
I6G73_RS06535	COG4181	ATPase activity
I6G73_RS06540	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6G73_RS06545	COG1090	epimerase
I6G73_RS06550	COG2200	EAL domain
I6G73_RS06555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G73_RS06560	COG4935	Belongs to the peptidase S8 family
I6G73_RS06560	COG2234	aminopeptidase activity
I6G73_RS06565	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6G73_RS06570	COG3171	Protein conserved in bacteria
I6G73_RS06575	COG2066	Belongs to the glutaminase family
I6G73_RS06580	COG2897	thiosulfate sulfurtransferase activity
I6G73_RS06585	COG1404	Belongs to the peptidase S8 family
I6G73_RS06595	COG1132	(ABC) transporter
I6G73_RS06620	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6G73_RS06625	COG3300	MHYT domain
I6G73_RS06625	COG5001	Diguanylate cyclase
I6G73_RS06635	COG2207	Transcriptional regulator
I6G73_RS06640	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G73_RS06645	COG3059	membrane
I6G73_RS06660	COG4628	conserved protein (DUF2132)
I6G73_RS06665	COG0688	phosphatidylethanolamine metabolic process
I6G73_RS06670	COG1162	GTPase activity
I6G73_RS06675	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6G73_RS06715	COG1278	Cold shock
I6G73_RS06725	COG0840	transmembrane signaling receptor activity
I6G73_RS06730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G73_RS06735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G73_RS06745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G73_RS06795	COG0848	biopolymer transport protein
I6G73_RS06800	COG0811	peptide transport
I6G73_RS06805	COG0811	peptide transport
I6G73_RS06820	COG4174	ABC transporter (Permease)
I6G73_RS06825	COG4239	(ABC) transporter, permease
I6G73_RS06835	COG0444	Belongs to the ABC transporter superfamily
I6G73_RS06840	COG4608	Belongs to the ABC transporter superfamily
I6G73_RS06845	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G73_RS06850	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6G73_RS06855	COG1073	alpha beta
I6G73_RS06870	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6G73_RS06900	COG0243	molybdopterin cofactor binding
I6G73_RS06915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G73_RS06915	COG1116	anion transmembrane transporter activity
I6G73_RS06920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G73_RS06925	COG1116	anion transmembrane transporter activity
I6G73_RS06930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G73_RS06930	COG2146	nitrite reductase [NAD(P)H] activity
I6G73_RS06935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G73_RS06935	COG2146	nitrite reductase [NAD(P)H] activity
I6G73_RS06940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G73_RS06945	COG2313	pseudouridylate synthase activity
I6G73_RS06950	COG2313	pseudouridylate synthase activity
I6G73_RS06960	COG1858	cytochrome C peroxidase
I6G73_RS06995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G73_RS07000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G73_RS07050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G73_RS07060	COG1028	Short-chain dehydrogenase reductase Sdr
I6G73_RS07075	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G73_RS07085	COG2966	Psort location CytoplasmicMembrane, score
I6G73_RS07090	COG3610	response to peptide
I6G73_RS07100	COG4175	Glycine betaine
I6G73_RS07105	COG4176	ABC-type proline glycine betaine transport system permease component
I6G73_RS07110	COG2113	Glycine betaine
I6G73_RS07115	COG0175	sulfate reduction
I6G73_RS07120	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G73_RS07125	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6G73_RS07130	COG0384	phenazine biosynthesis protein PhzF
I6G73_RS07135	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6G73_RS07150	COG0786	glutamate:sodium symporter activity
I6G73_RS07155	COG0252	asparaginase activity
I6G73_RS07160	COG3139	Protein of unknown function (DUF1315)
I6G73_RS07180	COG0616	signal peptide processing
I6G73_RS07185	COG1902	pentaerythritol trinitrate reductase activity
I6G73_RS07185	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G73_RS07190	COG0778	Nitroreductase
I6G73_RS07205	COG2264	protein methyltransferase activity
I6G73_RS07210	COG0604	alcohol dehydrogenase
I6G73_RS07215	COG0583	DNA-binding transcription factor activity
I6G73_RS07220	COG1263	PTS System
I6G73_RS07220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G73_RS07220	COG2190	(PTS) system
I6G73_RS07225	COG4145	pantothenate transmembrane transporter activity
I6G73_RS07235	COG0439	Biotin carboxylase
I6G73_RS07240	COG0511	ligase activity, forming carbon-carbon bonds
I6G73_RS07245	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6G73_RS07250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G73_RS07260	COG3300	MHYT domain
I6G73_RS07260	COG5001	Diguanylate cyclase
I6G73_RS07280	COG3381	protein complex oligomerization
I6G73_RS07295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6G73_RS07310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6G73_RS07315	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G73_RS07315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G73_RS07335	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6G73_RS07340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G73_RS07345	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6G73_RS07350	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6G73_RS07355	COG4172	Belongs to the ABC transporter superfamily
I6G73_RS07365	COG0601	transmembrane transport
I6G73_RS07375	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6G73_RS07380	COG0142	geranyltranstransferase activity
I6G73_RS07385	COG1722	exodeoxyribonuclease VII activity
I6G73_RS07390	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6G73_RS07395	COG1360	Flagellar Motor Protein
I6G73_RS07410	COG1534	Rna-binding protein
I6G73_RS07415	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6G73_RS07425	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G73_RS07430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G73_RS07435	COG0149	triose-phosphate isomerase activity
I6G73_RS07440	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G73_RS07455	COG0779	Required for maturation of 30S ribosomal subunits
I6G73_RS07460	COG0195	Participates in both transcription termination and antitermination
I6G73_RS07465	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6G73_RS07470	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6G73_RS07475	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6G73_RS07480	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6G73_RS07485	COG1185	polyribonucleotide nucleotidyltransferase activity
I6G73_RS07490	COG2211	Major facilitator Superfamily
I6G73_RS07495	COG3706	GGDEF domain
I6G73_RS07500	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6G73_RS07510	COG0114	fumarate hydratase activity
I6G73_RS07520	COG1966	Carbon starvation protein
I6G73_RS07525	COG3279	Response regulator of the LytR AlgR family
I6G73_RS07530	COG3275	phosphorelay sensor kinase activity
I6G73_RS07595	COG0312	modulator of DNA gyrase
I6G73_RS07600	COG0312	modulator of DNA gyrase
I6G73_RS07610	COG4974	Belongs to the 'phage' integrase family
I6G73_RS07615	COG1970	mechanosensitive ion channel activity
I6G73_RS07620	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G73_RS07630	COG0789	Transcriptional regulator
I6G73_RS07645	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6G73_RS07650	COG3545	Serine hydrolase
I6G73_RS07660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6G73_RS07665	COG0321	lipoyl(octanoyl) transferase activity
I6G73_RS07670	COG2921	Belongs to the UPF0250 family
I6G73_RS07675	COG1686	Belongs to the peptidase S11 family
I6G73_RS07680	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6G73_RS07685	COG2951	lytic endotransglycosylase activity
I6G73_RS07690	COG0772	Belongs to the SEDS family
I6G73_RS07695	COG0772	Belongs to the SEDS family
I6G73_RS07700	COG0768	penicillin binding
I6G73_RS07705	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6G73_RS07710	COG0799	negative regulation of ribosome biogenesis
I6G73_RS07715	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6G73_RS07735	COG0495	leucyl-tRNA aminoacylation
I6G73_RS07740	COG2888	peptidyl-tyrosine sulfation
I6G73_RS07745	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6G73_RS07750	COG4535	Mg2 and Co2 transporter CorC
I6G73_RS07755	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6G73_RS07760	COG1702	phosphate starvation-inducible protein PhoH
I6G73_RS07770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G73_RS07775	COG1335	isochorismatase
I6G73_RS07785	COG3706	GGDEF domain
I6G73_RS07790	COG0583	DNA-binding transcription factor activity
I6G73_RS07800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G73_RS07820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G73_RS07830	COG3647	Membrane
I6G73_RS07835	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6G73_RS07845	COG0516	GMP reductase activity
I6G73_RS07865	COG0642	Histidine kinase
I6G73_RS07905	COG3214	Protein conserved in bacteria
I6G73_RS07930	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6G73_RS07935	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G73_RS07940	COG1053	succinate dehydrogenase
I6G73_RS07950	COG0584	glycerophosphoryl diester phosphodiesterase
I6G73_RS07955	COG1511	domain protein
I6G73_RS07955	COG3264	Mechanosensitive ion channel
I6G73_RS07965	COG0739	heme binding
I6G73_RS07980	COG0583	DNA-binding transcription factor activity
I6G73_RS08000	COG0583	DNA-binding transcription factor activity
I6G73_RS08005	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6G73_RS08035	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6G73_RS08040	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6G73_RS08050	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6G73_RS08055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G73_RS08065	COG0180	Tryptophanyl-tRNA synthetase
I6G73_RS08080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G73_RS08090	COG1012	belongs to the aldehyde dehydrogenase family
I6G73_RS08100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G73_RS08110	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G73_RS08110	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6G73_RS08110	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6G73_RS08110	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6G73_RS08120	COG0366	Alpha amylase catalytic
I6G73_RS08130	COG3097	Belongs to the UPF0267 family
I6G73_RS08140	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I6G73_RS08150	COG0490	domain, Protein
I6G73_RS08150	COG0471	metal ion transport
I6G73_RS08195	COG0012	GTP binding
I6G73_RS08200	COG0193	aminoacyl-tRNA hydrolase activity
I6G73_RS08205	COG0737	Belongs to the 5'-nucleotidase family
I6G73_RS08210	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G73_RS08220	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6G73_RS08225	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6G73_RS08230	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6G73_RS08235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6G73_RS08240	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G73_RS08250	COG2912	Transglutaminase-like superfamily
I6G73_RS08255	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6G73_RS08260	COG1301	dicarboxylic acid transport
I6G73_RS08270	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6G73_RS08285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G73_RS08290	COG1115	amino acid carrier protein
I6G73_RS08305	COG0714	Associated with various cellular activities
I6G73_RS08315	COG3104	oligopeptide transport
I6G73_RS08320	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6G73_RS08325	COG1678	Uncharacterized ACR, COG1678
I6G73_RS08335	COG0189	ligase activity
I6G73_RS08340	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G73_RS08350	COG3091	SprT-like family
I6G73_RS08360	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6G73_RS08380	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6G73_RS08385	COG0739	heme binding
I6G73_RS08390	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6G73_RS08395	COG3408	Glycogen debranching enzyme
I6G73_RS08395	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6G73_RS08405	COG1881	PFAM PEBP family protein
I6G73_RS08410	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6G73_RS08415	COG0583	DNA-binding transcription factor activity
I6G73_RS08425	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6G73_RS08435	COG0583	DNA-binding transcription factor activity
I6G73_RS08440	COG1028	Short-chain dehydrogenase reductase Sdr
I6G73_RS08445	COG0616	signal peptide processing
I6G73_RS08450	COG3724	N-succinylarginine dihydrolase activity
I6G73_RS08470	COG0840	transmembrane signaling receptor activity
I6G73_RS08480	COG2971	BadF BadG BcrA BcrD
I6G73_RS08490	COG4608	Belongs to the ABC transporter superfamily
I6G73_RS08495	COG0444	Belongs to the ABC transporter superfamily
I6G73_RS08500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G73_RS08505	COG0601	transmembrane transport
I6G73_RS08510	COG4166	transmembrane transport
I6G73_RS08515	COG2205	protein histidine kinase activity
I6G73_RS08515	COG0784	Response regulator, receiver
I6G73_RS08545	COG3220	belongs to the UPF0276 family
I6G73_RS08575	COG1289	transmembrane transporter activity
I6G73_RS08580	COG0303	'Molybdopterin
I6G73_RS08585	COG0746	molybdenum cofactor guanylyltransferase activity
I6G73_RS08595	COG4662	Binding-protein-dependent transport system inner membrane component
I6G73_RS08605	COG2204	response regulator
I6G73_RS08610	COG3852	Histidine kinase
I6G73_RS08615	COG1910	domain protein
I6G73_RS08620	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6G73_RS08655	COG3383	formate dehydrogenase (NAD+) activity
I6G73_RS08655	COG3383	formate dehydrogenase (NAD+) activity
I6G73_RS08660	COG0437	4 iron, 4 sulfur cluster binding
I6G73_RS08675	COG0281	malic enzyme
I6G73_RS08685	COG2706	6-phosphogluconolactonase activity
I6G73_RS08695	COG1196	nuclear chromosome segregation
I6G73_RS08695	COG3264	Mechanosensitive ion channel
I6G73_RS08700	COG0469	pyruvate kinase activity
I6G73_RS08715	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G73_RS08715	COG4651	solute:proton antiporter activity
I6G73_RS08725	COG2974	May be involved in recombination
I6G73_RS08735	COG0420	3'-5' exonuclease activity
I6G73_RS08740	COG0419	ATPase involved in DNA repair
I6G73_RS08755	COG3038	cytochrome b561
I6G73_RS08770	COG2190	(PTS) system
I6G73_RS08780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G73_RS08785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G73_RS08790	COG0542	response to heat
I6G73_RS08805	COG1720	tRNA m6t6A37 methyltransferase activity
I6G73_RS08825	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6G73_RS08830	COG4988	ABC transporter
I6G73_RS08845	COG0745	RESPONSE REGULATOR receiver
I6G73_RS08855	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G73_RS08870	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6G73_RS08875	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6G73_RS08885	COG0083	homoserine kinase activity
I6G73_RS08890	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6G73_RS08895	COG4319	ketosteroid isomerase
I6G73_RS08900	COG0488	(ABC) transporter
I6G73_RS08915	COG0813	purine-nucleoside phosphorylase activity
I6G73_RS08930	COG2205	protein histidine kinase activity
I6G73_RS08930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G73_RS08935	COG3384	dioxygenase
I6G73_RS08945	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6G73_RS08955	COG0531	amino acid
I6G73_RS08965	COG0531	amino acid
I6G73_RS08980	COG1396	sequence-specific DNA binding
I6G73_RS08980	COG1917	Cupin 2, conserved barrel domain protein
I6G73_RS08985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G73_RS09005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G73_RS09010	COG2375	cellular response to nickel ion
I6G73_RS09020	COG0577	efflux transmembrane transporter activity
I6G73_RS09020	COG1136	(ABC) transporter
I6G73_RS09025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G73_RS09040	COG0497	DNA recombination
I6G73_RS09045	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6G73_RS09050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6G73_RS09055	COG0443	Heat shock 70 kDa protein
I6G73_RS09060	COG0484	heat shock protein binding
I6G73_RS09065	COG2239	Acts as a magnesium transporter
I6G73_RS09075	COG1285	pathogenesis
I6G73_RS09120	COG0095	Lipoate-protein ligase
I6G73_RS09140	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G73_RS09145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G73_RS09165	COG0708	Exodeoxyribonuclease III
I6G73_RS09180	COG2211	Major facilitator Superfamily
I6G73_RS09230	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6G73_RS09235	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G73_RS09240	COG1845	cytochrome c oxidase, subunit III
I6G73_RS09245	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6G73_RS09250	COG0109	protoheme IX farnesyltransferase activity
I6G73_RS09255	COG2814	Major facilitator Superfamily
I6G73_RS09270	COG3152	Membrane
I6G73_RS09285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G73_RS09335	COG0159	tryptophan synthase activity
I6G73_RS09340	COG0133	tryptophan synthase activity
I6G73_RS09345	COG0135	phosphoribosylanthranilate isomerase activity
I6G73_RS09345	COG0134	indole-3-glycerol-phosphate synthase activity
I6G73_RS09350	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G73_RS09355	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G73_RS09355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G73_RS09360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6G73_RS09365	COG0613	PHP domain protein
I6G73_RS09370	COG0009	L-threonylcarbamoyladenylate synthase
I6G73_RS09380	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6G73_RS09390	COG1946	Acyl-CoA thioesterase
I6G73_RS09405	COG1309	transcriptional regulator
I6G73_RS09410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G73_RS09415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G73_RS09430	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6G73_RS09450	COG0110	maltose O-acetyltransferase activity
I6G73_RS09455	COG0110	maltose O-acetyltransferase activity
I6G73_RS09475	COG0110	maltose O-acetyltransferase activity
I6G73_RS09495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G73_RS09515	COG3132	Protein of unknown function, DUF480
I6G73_RS09555	COG1278	Cold shock
I6G73_RS09590	COG1349	DNA-binding transcription factor activity
I6G73_RS09595	COG1882	Formate acetyltransferase
I6G73_RS09600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G73_RS09605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G73_RS09635	COG0622	Phosphoesterase
I6G73_RS09650	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6G73_RS09655	COG0784	Response regulator, receiver
I6G73_RS09655	COG0835	chemotaxis
I6G73_RS09660	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6G73_RS09665	COG1815	bacterial-type flagellum-dependent cell motility
I6G73_RS09685	COG4787	bacterial-type flagellum-dependent cell motility
I6G73_RS09695	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6G73_RS09700	COG1706	bacterial-type flagellum-dependent cell motility
I6G73_RS09705	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6G73_RS09705	COG3951	Flagellar rod assembly protein muramidase FlgJ
I6G73_RS09710	COG1256	bacterial-type flagellum assembly
I6G73_RS09720	COG2239	Acts as a magnesium transporter
I6G73_RS09730	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6G73_RS09735	COG2716	regulation of RNA biosynthetic process
I6G73_RS09760	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G73_RS09765	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G73_RS09770	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6G73_RS09775	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6G73_RS09795	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6G73_RS09815	COG0573	inorganic phosphate transmembrane transporter activity
I6G73_RS09820	COG0581	inorganic phosphate transmembrane transporter activity
I6G73_RS09825	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G73_RS09830	COG0704	Plays a role in the regulation of phosphate uptake
I6G73_RS09835	COG1253	flavin adenine dinucleotide binding
I6G73_RS09850	COG0531	amino acid
I6G73_RS09870	COG1126	abc transporter atp-binding protein
I6G73_RS09875	COG0765	amino acid transport
I6G73_RS09880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G73_RS09890	COG2271	Major facilitator Superfamily
I6G73_RS09905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G73_RS09930	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6G73_RS09935	COG0477	Major facilitator Superfamily
I6G73_RS09940	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6G73_RS09950	COG1199	ATP-dependent helicase activity
I6G73_RS09965	COG1448	Aminotransferase
I6G73_RS09970	COG0433	COG0433 Predicted ATPase
I6G73_RS09985	COG2333	competence protein COMEC
I6G73_RS09985	COG0658	competence protein
I6G73_RS09995	COG1663	tetraacyldisaccharide 4'-kinase activity
I6G73_RS10000	COG2835	tetraacyldisaccharide 4'-kinase activity
I6G73_RS10005	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6G73_RS10010	COG2197	response regulator
I6G73_RS10015	COG0322	excinuclease ABC activity
I6G73_RS10050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G73_RS10060	COG4974	Belongs to the 'phage' integrase family
I6G73_RS10100	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6G73_RS10105	COG0437	4 iron, 4 sulfur cluster binding
I6G73_RS10110	COG3301	Polysulphide reductase, NrfD
I6G73_RS10115	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G73_RS10125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G73_RS10145	COG2199	diguanylate cyclase activity
I6G73_RS10145	COG2203	Gaf domain
I6G73_RS10175	COG2119	membrane
I6G73_RS10180	COG0023	Translation Initiation Factor
I6G73_RS10205	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6G73_RS10220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G73_RS10220	COG2205	protein histidine kinase activity
I6G73_RS10230	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I6G73_RS10240	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G73_RS10245	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6G73_RS10250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G73_RS10255	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6G73_RS10260	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G73_RS10270	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6G73_RS10275	COG0505	Belongs to the CarA family
I6G73_RS10280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6G73_RS10285	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G73_RS10315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G73_RS10320	COG0513	Belongs to the DEAD box helicase family
I6G73_RS10330	COG4104	PAAR repeat-containing protein
I6G73_RS10345	COG0789	Transcriptional regulator
I6G73_RS10360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G73_RS10365	COG0765	amino acid transport
I6G73_RS10370	COG1126	abc transporter atp-binding protein
I6G73_RS10375	COG0493	'glutamate synthase
I6G73_RS10380	COG0067	glutamate synthase
I6G73_RS10380	COG0070	glutamate synthase
I6G73_RS10380	COG0069	glutamate synthase activity
I6G73_RS10385	COG1242	4 iron, 4 sulfur cluster binding
I6G73_RS10450	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6G73_RS10455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G73_RS10455	COG0574	Belongs to the PEP-utilizing enzyme family
I6G73_RS10495	COG1464	Belongs to the NlpA lipoprotein family
I6G73_RS10500	COG0671	phosphoesterase, PA-phosphatase related
I6G73_RS10505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G73_RS10510	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G73_RS10520	COG0101	tRNA pseudouridine synthase activity
I6G73_RS10525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6G73_RS10530	COG0285	dihydrofolate synthase activity
I6G73_RS10535	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6G73_RS10540	COG2920	part of a sulfur-relay system
I6G73_RS10545	COG1289	transmembrane transporter activity
I6G73_RS10550	COG0670	Belongs to the BI1 family
I6G73_RS10565	COG4792	protein secretion
I6G73_RS10570	COG4791	protein targeting
I6G73_RS10575	COG4794	Type iii secretion
I6G73_RS10580	COG4790	Type iii secretion
I6G73_RS10740	COG1317	bacterial-type flagellum organization
I6G73_RS10755	COG2194	sulfuric ester hydrolase activity
I6G73_RS10760	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6G73_RS10760	COG0392	lysyltransferase activity
I6G73_RS10770	COG0840	transmembrane signaling receptor activity
I6G73_RS10775	COG5001	Diguanylate cyclase
I6G73_RS10780	COG0564	pseudouridine synthase activity
I6G73_RS10795	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6G73_RS10805	COG0625	glutathione transferase activity
I6G73_RS10810	COG0625	glutathione transferase activity
I6G73_RS10820	COG0367	asparagine synthase
I6G73_RS10830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G73_RS10830	COG4651	solute:proton antiporter activity
I6G73_RS10835	COG0647	UMP catabolic process
I6G73_RS10840	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6G73_RS10845	COG1902	pentaerythritol trinitrate reductase activity
I6G73_RS10850	COG1253	flavin adenine dinucleotide binding
I6G73_RS10860	COG0247	lactate metabolic process
I6G73_RS10860	COG0277	FAD linked oxidase domain protein
I6G73_RS10870	COG2050	protein possibly involved in aromatic compounds catabolism
I6G73_RS10880	COG2056	Na+-H+ antiporter family
I6G73_RS10885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G73_RS10900	COG0346	lactoylglutathione lyase activity
I6G73_RS10905	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G73_RS10910	COG4660	Part of a membrane complex involved in electron transport
I6G73_RS10915	COG4659	FMN binding
I6G73_RS10920	COG4658	electron transport chain
I6G73_RS10930	COG2878	Part of a membrane complex involved in electron transport
I6G73_RS10935	COG4657	Part of a membrane complex involved in electron transport
I6G73_RS10940	COG0697	spore germination
I6G73_RS10950	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6G73_RS10955	COG1288	antiporter activity
I6G73_RS10960	COG0436	Aminotransferase
I6G73_RS10970	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6G73_RS10975	COG2027	D-alanyl-D-alanine carboxypeptidase
I6G73_RS10980	COG1061	Type III restriction enzyme res subunit
I6G73_RS10985	COG1566	PFAM secretion protein HlyD family protein
I6G73_RS10995	COG1966	Carbon starvation protein
I6G73_RS11000	COG3279	Response regulator of the LytR AlgR family
I6G73_RS11005	COG3275	phosphorelay sensor kinase activity
I6G73_RS11010	COG2199	diguanylate cyclase activity
I6G73_RS11010	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6G73_RS11015	COG1454	alcohol dehydrogenase
I6G73_RS11015	COG1012	belongs to the aldehyde dehydrogenase family
I6G73_RS11025	COG2095	MarC family integral membrane protein
I6G73_RS11035	COG0601	transmembrane transport
I6G73_RS11040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G73_RS11055	COG0861	Integral membrane protein TerC family
I6G73_RS11060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G73_RS11070	COG1301	dicarboxylic acid transport
I6G73_RS11085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6G73_RS11100	COG0537	adenosine 5'-monophosphoramidase activity
I6G73_RS11135	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G73_RS11140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G73_RS11150	COG2354	Protein conserved in bacteria
I6G73_RS11165	COG2233	PERMEase
I6G73_RS11170	COG3150	esterase
I6G73_RS11175	COG1252	NADH dehydrogenase
I6G73_RS11195	COG0393	Putative heavy-metal-binding
I6G73_RS11205	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6G73_RS11210	COG1368	sulfuric ester hydrolase activity
I6G73_RS11220	COG0527	aspartate kinase activity
I6G73_RS11225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6G73_RS11225	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6G73_RS11230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G73_RS11250	COG0596	Alpha beta hydrolase
I6G73_RS11255	COG0346	lactoylglutathione lyase activity
I6G73_RS11265	COG0583	DNA-binding transcription factor activity
I6G73_RS11280	COG1139	Iron-sulfur cluster binding protein
I6G73_RS11325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G73_RS11330	COG0840	transmembrane signaling receptor activity
I6G73_RS11340	COG2201	protein-glutamate methylesterase activity
I6G73_RS11350	COG0835	chemotaxis
I6G73_RS11355	COG3290	protein histidine kinase activity
I6G73_RS11355	COG0840	transmembrane signaling receptor activity
I6G73_RS11360	COG2198	Histidine kinase
I6G73_RS11360	COG0643	Histidine kinase
I6G73_RS11370	COG0745	RESPONSE REGULATOR receiver
I6G73_RS11375	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6G73_RS11380	COG0437	4 iron, 4 sulfur cluster binding
I6G73_RS11385	COG5557	Pfam Polysulphide reductase, NrfD
I6G73_RS11390	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6G73_RS11395	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6G73_RS11400	COG1773	rubredoxin
I6G73_RS11410	COG0601	transmembrane transport
I6G73_RS11415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G73_RS11425	COG3842	ATPase activity
I6G73_RS11430	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6G73_RS11440	COG0375	protein maturation
I6G73_RS11445	COG0309	Hydrogenase expression formation protein (HypE)
I6G73_RS11455	COG0298	carbon dioxide binding
I6G73_RS11460	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6G73_RS11470	COG1921	L-seryl-tRNASec selenium transferase activity
I6G73_RS11480	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6G73_RS11490	COG3260	NADH ubiquinone oxidoreductase 20
I6G73_RS11495	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G73_RS11500	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6G73_RS11500	COG3261	NADH dehydrogenase
I6G73_RS11505	COG0650	Formate hydrogenlyase subunit 4
I6G73_RS11510	COG0651	ATP synthesis coupled electron transport
I6G73_RS11515	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G73_RS11520	COG3158	transport of potassium into the cell
I6G73_RS11530	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G73_RS11555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6G73_RS11560	COG0326	Molecular chaperone. Has ATPase activity
I6G73_RS11565	COG0563	adenylate kinase activity
I6G73_RS11570	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6G73_RS11580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G73_RS11595	COG3300	MHYT domain
I6G73_RS11595	COG5001	Diguanylate cyclase
I6G73_RS11600	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6G73_RS11620	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6G73_RS11625	COG3433	isochorismatase activity
I6G73_RS11625	COG1535	isochorismatase
I6G73_RS11630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G73_RS11635	COG1028	Short-chain dehydrogenase reductase Sdr
I6G73_RS11645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G73_RS11650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G73_RS11660	COG1120	ATPase activity
I6G73_RS11665	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G73_RS11670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G73_RS11675	COG4771	TonB-dependent receptor
I6G73_RS11715	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6G73_RS11720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6G73_RS11725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G73_RS11740	COG1570	exodeoxyribonuclease VII activity
I6G73_RS11745	COG0697	spore germination
I6G73_RS11765	COG3158	transport of potassium into the cell
I6G73_RS11770	COG0517	IMP dehydrogenase activity
I6G73_RS11770	COG0516	GMP reductase activity
I6G73_RS11775	COG0519	Catalyzes the synthesis of GMP from XMP
I6G73_RS11775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G73_RS11815	COG2062	phosphohistidine phosphatase, SixA
I6G73_RS11825	COG0697	spore germination
I6G73_RS11830	COG4166	transmembrane transport
I6G73_RS11835	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6G73_RS11840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G73_RS11850	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G73_RS11855	COG1136	(ABC) transporter
I6G73_RS11860	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G73_RS11865	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6G73_RS11875	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6G73_RS11880	COG0740	serine-type endopeptidase activity
I6G73_RS11885	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6G73_RS11890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6G73_RS11895	COG0776	regulation of translation
I6G73_RS11900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G73_RS11905	COG0488	(ABC) transporter
I6G73_RS11910	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G73_RS11915	COG3162	membrane
I6G73_RS11930	COG1024	Enoyl-CoA hydratase
I6G73_RS11970	COG1115	amino acid carrier protein
I6G73_RS11985	COG1584	GPR1 FUN34 yaaH family protein
I6G73_RS12020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6G73_RS12025	COG1960	acyl-CoA dehydrogenase activity
I6G73_RS12035	COG1960	acyl-CoA dehydrogenase activity
I6G73_RS12040	COG1024	Enoyl-CoA hydratase
I6G73_RS12045	COG1024	Enoyl-CoA hydratase
I6G73_RS12055	COG1028	Short-chain dehydrogenase reductase Sdr
I6G73_RS12065	COG0730	response to heat
I6G73_RS12075	COG0583	DNA-binding transcription factor activity
I6G73_RS12080	COG0667	Aldo Keto reductase
I6G73_RS12095	COG3706	GGDEF domain
I6G73_RS12100	COG0583	DNA-binding transcription factor activity
I6G73_RS12105	COG2723	6-phospho-beta-galactosidase activity
I6G73_RS12110	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6G73_RS12120	COG0583	DNA-binding transcription factor activity
I6G73_RS12125	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6G73_RS12130	COG0673	inositol 2-dehydrogenase activity
I6G73_RS12135	COG0583	DNA-binding transcription factor activity
I6G73_RS12145	COG1560	Kdo2-lipid A biosynthetic process
I6G73_RS12150	COG1560	Kdo2-lipid A biosynthetic process
I6G73_RS12175	COG0417	DNA replication proofreading
I6G73_RS12200	COG0534	Mate efflux family protein
I6G73_RS12210	COG0307	riboflavin synthase, alpha
I6G73_RS12220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G73_RS12225	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6G73_RS12230	COG0697	spore germination
I6G73_RS12235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6G73_RS12275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G73_RS12280	COG3099	Belongs to the UPF0263 family
I6G73_RS12285	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6G73_RS12290	COG2894	cell division
I6G73_RS12295	COG0850	regulation of cytokinetic process
I6G73_RS12300	COG3100	YcgL domain-containing protein
I6G73_RS12305	COG2951	lytic endotransglycosylase activity
I6G73_RS12310	COG1760	l-serine dehydratase
I6G73_RS12315	COG1760	l-serine dehydratase
I6G73_RS12320	COG3123	guanosine phosphorylase activity
I6G73_RS12350	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I6G73_RS12355	COG2067	long-chain fatty acid transport protein
I6G73_RS12370	COG1595	DNA-templated transcription, initiation
I6G73_RS12400	COG0714	Associated with various cellular activities
I6G73_RS12405	COG0183	Belongs to the thiolase family
I6G73_RS12410	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G73_RS12410	COG1024	Enoyl-CoA hydratase
I6G73_RS12465	COG3829	transcription factor binding
I6G73_RS12470	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6G73_RS12475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G73_RS12480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G73_RS12490	COG0549	Belongs to the carbamate kinase family
I6G73_RS12495	COG0697	spore germination
I6G73_RS12500	COG3608	succinylglutamate desuccinylase aspartoacylase
I6G73_RS12500	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6G73_RS12505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G73_RS12510	COG2068	MobA-Related Protein
I6G73_RS12515	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G73_RS12515	COG0493	'glutamate synthase
I6G73_RS12520	COG0402	S-adenosylhomocysteine deaminase activity
I6G73_RS12525	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6G73_RS12530	COG2080	2 iron, 2 sulfur cluster binding
I6G73_RS12530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6G73_RS12535	COG2233	PERMEase
I6G73_RS12540	COG0402	S-adenosylhomocysteine deaminase activity
I6G73_RS12545	COG2252	PERMEase
I6G73_RS12550	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6G73_RS12555	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6G73_RS12560	COG2080	2 iron, 2 sulfur cluster binding
I6G73_RS12570	COG3134	Outer membrane lipoprotein
I6G73_RS12580	COG1288	antiporter activity
I6G73_RS12585	COG0318	PFAM AMP-dependent synthetase and ligase
I6G73_RS12595	COG0140	phosphoribosyl-ATP diphosphatase activity
I6G73_RS12595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6G73_RS12600	COG0107	imidazoleglycerol-phosphate synthase activity
I6G73_RS12605	COG0784	Response regulator, receiver
I6G73_RS12605	COG2205	protein histidine kinase activity
I6G73_RS12605	COG2198	Histidine kinase
I6G73_RS12610	COG2199	diguanylate cyclase activity
I6G73_RS12615	COG3437	response regulator, receiver
I6G73_RS12620	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6G73_RS12625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6G73_RS12630	COG0131	Imidazoleglycerol-phosphate dehydratase
I6G73_RS12630	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6G73_RS12635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G73_RS12640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6G73_RS12645	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6G73_RS12655	COG1199	ATP-dependent helicase activity
I6G73_RS12660	COG1214	PFAM Peptidase M22, glycoprotease
I6G73_RS12670	COG2226	methyltransferase
I6G73_RS12670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G73_RS12670	COG0596	Alpha beta hydrolase
I6G73_RS12675	COG0318	PFAM AMP-dependent synthetase and ligase
I6G73_RS12680	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6G73_RS12695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G73_RS12700	COG2832	Protein of unknown function (DUF454)
I6G73_RS12705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G73_RS12715	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6G73_RS12730	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6G73_RS12730	COG0617	tRNA 3'-terminal CCA addition
I6G73_RS12730	COG0517	IMP dehydrogenase activity
I6G73_RS12735	COG1643	Atp-dependent helicase
I6G73_RS12745	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6G73_RS12755	COG3437	response regulator, receiver
I6G73_RS12760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G73_RS12765	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6G73_RS12770	COG0709	Synthesizes selenophosphate from selenide and ATP
I6G73_RS12785	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G73_RS12795	COG1254	Belongs to the acylphosphatase family
I6G73_RS12800	COG0625	glutathione transferase activity
I6G73_RS12805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G73_RS12805	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G73_RS12810	COG0489	protein tyrosine kinase activity
I6G73_RS12815	COG0572	uridine kinase
I6G73_RS12820	COG0717	Belongs to the dCTP deaminase family
I6G73_RS12825	COG0306	phosphate transporter
I6G73_RS12830	COG1530	ribonuclease E activity
I6G73_RS12835	COG0564	pseudouridine synthase activity
I6G73_RS12840	COG0546	phosphoglycolate phosphatase activity
I6G73_RS12845	COG0424	maF-like protein
I6G73_RS12850	COG2814	Major facilitator Superfamily
I6G73_RS12865	COG1399	metal-binding, possibly nucleic acid-binding protein
I6G73_RS12870	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6G73_RS12875	COG0416	fatty acid biosynthetic process
I6G73_RS12880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G73_RS12890	COG1028	Short-chain dehydrogenase reductase Sdr
I6G73_RS12895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G73_RS12905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G73_RS12910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G73_RS12915	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6G73_RS12920	COG0470	DNA polymerase III
I6G73_RS12925	COG0084	hydrolase, TatD family'
I6G73_RS12940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G73_RS12940	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6G73_RS12945	COG3008	intermembrane lipid transfer
I6G73_RS12950	COG2995	paraquat-inducible protein a
I6G73_RS12960	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6G73_RS12965	COG0372	Belongs to the citrate synthase family
I6G73_RS13010	COG4221	oxidoreductase activity
I6G73_RS13020	COG3141	response to X-ray
I6G73_RS13045	COG4128	Pfam Zonular occludens toxin
I6G73_RS13085	COG1067	ATP-dependent peptidase activity
I6G73_RS13090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G73_RS13105	COG0488	(ABC) transporter
I6G73_RS13115	COG0116	Belongs to the methyltransferase superfamily
I6G73_RS13115	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G73_RS13125	COG0167	dihydroorotate dehydrogenase activity
I6G73_RS13130	COG2902	Dehydrogenase
I6G73_RS13140	COG0308	aminopeptidase N
I6G73_RS13150	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I6G73_RS13155	COG1956	GAF domain-containing protein
I6G73_RS13165	COG3278	Belongs to the heme-copper respiratory oxidase family
I6G73_RS13180	COG2010	Cytochrome c
I6G73_RS13205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G73_RS13210	COG0589	response to stress
I6G73_RS13215	COG0037	tRNA processing
I6G73_RS13235	COG1869	D-ribose catabolic process
I6G73_RS13240	COG1129	ABC transporter
I6G73_RS13245	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G73_RS13250	COG1879	ABC-type sugar transport system periplasmic component
I6G73_RS13255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G73_RS13260	COG1609	Transcriptional regulator
I6G73_RS13265	COG2199	diguanylate cyclase activity
I6G73_RS13295	COG0776	regulation of translation
I6G73_RS13300	COG0072	phenylalanine-tRNA ligase activity
I6G73_RS13300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G73_RS13305	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6G73_RS13310	COG4974	Belongs to the 'phage' integrase family
I6G73_RS13330	COG3620	sequence-specific DNA binding
I6G73_RS13390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G73_RS13420	COG4695	Portal protein
I6G73_RS13540	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6G73_RS13545	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6G73_RS13550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6G73_RS13555	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G73_RS13580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G73_RS13590	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G73_RS13595	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G73_RS13600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G73_RS13605	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6G73_RS13610	COG3313	Fe-S protein
I6G73_RS13615	COG2942	2-epimerase
I6G73_RS13620	COG3716	PTS system mannose fructose sorbose family IID component
I6G73_RS13625	COG3715	PTS system
I6G73_RS13630	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G73_RS13630	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G73_RS13645	COG1609	Transcriptional regulator
I6G73_RS13650	COG2140	Oxalate decarboxylase
I6G73_RS13655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G73_RS13655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G73_RS13655	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6G73_RS13660	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G73_RS13665	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G73_RS13665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G73_RS13670	COG1609	Transcriptional regulator
I6G73_RS13675	COG0814	amino acid
I6G73_RS13685	COG5654	RES domain protein
I6G73_RS13690	COG0513	Belongs to the DEAD box helicase family
I6G73_RS13700	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6G73_RS13705	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G73_RS13710	COG2840	Smr protein MutS2
I6G73_RS13720	COG3706	GGDEF domain
I6G73_RS13725	COG0588	phosphoglycerate mutase activity
I6G73_RS13750	COG2824	Alkylphosphonate utilization operon protein PhnA
I6G73_RS13760	COG0384	phenazine biosynthesis protein PhzF
I6G73_RS13775	COG2205	protein histidine kinase activity
I6G73_RS13775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G73_RS13790	COG3188	usher protein
I6G73_RS13795	COG3121	Chaperone
I6G73_RS13810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G73_RS13835	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6G73_RS13840	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6G73_RS13850	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G73_RS13855	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6G73_RS13865	COG0205	6-phosphofructokinase activity
I6G73_RS13870	COG1473	amidohydrolase
I6G73_RS13875	COG1011	Hydrolase
I6G73_RS13880	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6G73_RS13930	COG3593	DNA synthesis involved in DNA repair
I6G73_RS13945	COG0583	DNA-binding transcription factor activity
I6G73_RS13950	COG0730	response to heat
I6G73_RS13960	COG3148	PFAM DTW domain containing protein
I6G73_RS13970	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G73_RS13980	COG0386	Belongs to the glutathione peroxidase family
I6G73_RS13985	COG0513	Belongs to the DEAD box helicase family
I6G73_RS13990	COG0456	acetyltransferase
I6G73_RS14000	COG1742	UPF0060 membrane protein
I6G73_RS14030	COG2329	Antibiotic biosynthesis monooxygenase
I6G73_RS14035	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6G73_RS14055	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6G73_RS14065	COG2501	S4 domain
I6G73_RS14080	COG1132	(ABC) transporter
I6G73_RS14085	COG1132	(ABC) transporter
I6G73_RS14095	COG3118	belongs to the thioredoxin family
I6G73_RS14100	COG0471	metal ion transport
I6G73_RS14105	COG0058	SHG alpha-glucan phosphorylase activity
I6G73_RS14135	COG0814	amino acid
I6G73_RS14140	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6G73_RS14145	COG0514	ATP-dependent DNA helicase (RecQ)
I6G73_RS14150	COG2766	serine protein kinase
I6G73_RS14160	COG2719	SpoVR family
I6G73_RS14165	COG2186	Transcriptional regulator
I6G73_RS14170	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6G73_RS14175	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6G73_RS14180	COG0586	Pfam SNARE associated Golgi protein
I6G73_RS14190	COG0556	nucleotide-excision repair
I6G73_RS14200	COG2985	domain, Protein
I6G73_RS14200	COG0569	domain protein
I6G73_RS14205	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6G73_RS14225	COG4565	transcriptional regulatory protein
I6G73_RS14230	COG3290	protein histidine kinase activity
I6G73_RS14235	COG1846	Transcriptional regulator
I6G73_RS14235	COG1940	carbohydrate kinase activity
I6G73_RS14240	COG0840	transmembrane signaling receptor activity
I6G73_RS14245	COG3012	SEC-C Motif Domain Protein
I6G73_RS14250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G73_RS14255	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
I6G73_RS14260	COG0247	lactate metabolic process
I6G73_RS14280	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6G73_RS14285	COG0437	4 iron, 4 sulfur cluster binding
I6G73_RS14290	COG3301	Polysulphide reductase, NrfD
I6G73_RS14295	COG1138	Cytochrome C-type biogenesis protein
I6G73_RS14300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G73_RS14305	COG4235	cytochrome complex assembly
I6G73_RS14305	COG3088	subunit of a heme lyase
I6G73_RS14310	COG1051	belongs to the nudix hydrolase family
I6G73_RS14320	COG3033	Beta-eliminating lyase
I6G73_RS14330	COG3046	protein related to deoxyribodipyrimidine photolyase
I6G73_RS14335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G73_RS14360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6G73_RS14375	COG4774	siderophore transport
I6G73_RS14380	COG4977	sequence-specific DNA binding
I6G73_RS14390	COG0583	DNA-binding transcription factor activity
I6G73_RS14395	COG2910	NAD(P)H-binding
I6G73_RS14410	COG0612	Peptidase, M16
I6G73_RS14415	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G73_RS14425	COG1944	ATP diphosphatase activity
I6G73_RS14430	COG2116	formate transmembrane transporter activity
I6G73_RS14435	COG1882	Formate acetyltransferase
I6G73_RS14440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G73_RS14450	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6G73_RS14460	COG1840	ABC-type Fe3 transport system, periplasmic component
I6G73_RS14465	COG3842	ATPase activity
I6G73_RS14475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G73_RS14480	COG2983	Belongs to the UPF0260 family
I6G73_RS14495	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6G73_RS14500	COG0045	succinate-CoA ligase (ADP-forming) activity
I6G73_RS14505	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G73_RS14510	COG0567	Dehydrogenase, E1 component
I6G73_RS14520	COG1053	succinate dehydrogenase
I6G73_RS14525	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6G73_RS14550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G73_RS14555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G73_RS14555	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6G73_RS14565	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G73_RS14580	COG1451	nucleotide metabolic process
I6G73_RS14595	COG0254	rRNA binding
I6G73_RS14600	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G73_RS14610	COG0583	DNA-binding transcription factor activity
I6G73_RS14620	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G73_RS14630	COG1879	ABC-type sugar transport system periplasmic component
I6G73_RS14635	COG1069	ribulokinase activity
I6G73_RS14645	COG2160	L-arabinose isomerase activity
I6G73_RS14650	COG2925	Exonuclease
I6G73_RS14660	COG3345	alpha-galactosidase
I6G73_RS14665	COG1380	Effector of murein hydrolase LrgA
I6G73_RS14670	COG1346	cytolysis
I6G73_RS14675	COG0295	cytidine deaminase activity
I6G73_RS14680	COG1022	Amp-dependent synthetase and ligase
I6G73_RS14695	COG0861	Integral membrane protein TerC family
I6G73_RS14700	COG2885	chlorophyll binding
I6G73_RS14705	COG2199	diguanylate cyclase activity
I6G73_RS14730	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6G73_RS14740	COG3768	UPF0283 membrane protein
I6G73_RS14745	COG3106	COG3106 Predicted ATPase
I6G73_RS14760	COG1842	Phage shock protein A
I6G73_RS14765	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6G73_RS14775	COG4168	peptide transport system, permease
I6G73_RS14780	COG4171	peptide transport system, permease
I6G73_RS14790	COG4172	Belongs to the ABC transporter superfamily
I6G73_RS14800	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6G73_RS14805	COG1286	toxin biosynthetic process
I6G73_RS14810	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6G73_RS14815	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G73_RS14820	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6G73_RS14825	COG1674	ftsk spoiiie
I6G73_RS14825	COG0531	amino acid
I6G73_RS14835	COG0686	Belongs to the AlaDH PNT family
I6G73_RS14840	COG0492	ferredoxin-NADP+ reductase activity
I6G73_RS14845	COG3706	GGDEF domain
I6G73_RS14850	COG3134	Outer membrane lipoprotein
I6G73_RS14855	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6G73_RS14860	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6G73_RS14865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6G73_RS14870	COG0542	response to heat
I6G73_RS14875	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6G73_RS14880	COG1278	Cold shock
I6G73_RS14885	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6G73_RS14945	COG3829	transcription factor binding
I6G73_RS15010	COG3209	COG3209 Rhs family protein
I6G73_RS15020	COG3501	Rhs element vgr protein
I6G73_RS15035	COG0659	secondary active sulfate transmembrane transporter activity
I6G73_RS15065	COG0672	)-iron permease
I6G73_RS15085	COG2814	Major facilitator Superfamily
I6G73_RS15095	COG1136	(ABC) transporter
I6G73_RS15100	COG0577	efflux transmembrane transporter activity
I6G73_RS15125	COG1435	thymidine kinase activity
I6G73_RS15130	COG1757	Na H antiporter
I6G73_RS15135	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6G73_RS15140	COG2096	Adenosyltransferase
I6G73_RS15145	COG3530	Putative quorum-sensing-regulated virulence factor
I6G73_RS15150	COG0602	queuosine metabolic process
I6G73_RS15155	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6G73_RS15175	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6G73_RS15185	COG0776	regulation of translation
I6G73_RS15190	COG0539	negative regulation of cytoplasmic translation
I6G73_RS15195	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6G73_RS15200	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6G73_RS15210	COG0583	DNA-binding transcription factor activity
I6G73_RS15215	COG2814	Major facilitator Superfamily
I6G73_RS15230	COG0778	Nitroreductase
I6G73_RS15235	COG3300	MHYT domain
I6G73_RS15235	COG5001	Diguanylate cyclase
I6G73_RS15245	COG0583	DNA-binding transcription factor activity
I6G73_RS15250	COG3437	response regulator, receiver
I6G73_RS15275	COG4989	oxidoreductase activity
I6G73_RS15280	COG0724	RNA recognition motif
I6G73_RS15300	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6G73_RS15320	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6G73_RS15325	COG1360	Flagellar Motor Protein
I6G73_RS15330	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G73_RS15335	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G73_RS15340	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G73_RS15340	COG0649	NAD binding
I6G73_RS15355	COG1034	ATP synthesis coupled electron transport
I6G73_RS15360	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6G73_RS15365	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G73_RS15370	COG0839	Belongs to the complex I subunit 6 family
I6G73_RS15375	COG0713	ATP synthesis coupled electron transport
I6G73_RS15385	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G73_RS15390	COG1007	ATP synthesis coupled electron transport
I6G73_RS15395	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G73_RS15395	COG0047	phosphoribosylformylglycinamidine synthase activity
I6G73_RS15400	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6G73_RS15405	COG1645	bacterial-type flagellum-dependent swarming motility
I6G73_RS15410	COG1160	GTP binding
I6G73_RS15415	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G73_RS15420	COG2976	Protein conserved in bacteria
I6G73_RS15425	COG0124	histidyl-tRNA synthetase
I6G73_RS15430	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6G73_RS15445	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6G73_RS15450	COG0105	UTP biosynthetic process
I6G73_RS15455	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6G73_RS15465	COG0633	Ferredoxin
I6G73_RS15470	COG0443	Heat shock 70 kDa protein
I6G73_RS15475	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6G73_RS15485	COG0822	iron-sulfur transferase activity
I6G73_RS15490	COG1104	cysteine desulfurase activity
I6G73_RS15510	COG3154	lipid carrier protein
I6G73_RS15515	COG0826	peptidase U32
I6G73_RS15520	COG0826	peptidase U32
I6G73_RS15535	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G73_RS15540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G73_RS15545	COG1862	Preprotein translocase
I6G73_RS15550	COG0343	queuine tRNA-ribosyltransferase activity
I6G73_RS15555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6G73_RS15560	COG0517	IMP dehydrogenase activity
I6G73_RS15570	COG3634	alkyl hydroperoxide reductase activity
I6G73_RS15575	COG0477	Major facilitator Superfamily
I6G73_RS15590	COG1393	Belongs to the ArsC family
I6G73_RS15595	COG0798	PFAM Bile acid sodium symporter
I6G73_RS15610	COG0640	Transcriptional regulator
I6G73_RS15625	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6G73_RS15625	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6G73_RS15630	COG0509	glycine decarboxylation via glycine cleavage system
I6G73_RS15635	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6G73_RS15640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G73_RS15645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G73_RS15665	COG2814	Major facilitator Superfamily
I6G73_RS15670	COG0625	glutathione transferase activity
I6G73_RS15680	COG0483	inositol monophosphate 1-phosphatase activity
I6G73_RS15685	COG0840	transmembrane signaling receptor activity
I6G73_RS15700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G73_RS15765	COG0301	tRNA thio-modification
I6G73_RS15765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G73_RS15775	COG4953	penicillin-binding protein 1C
I6G73_RS15780	COG2373	Large extracellular alpha-helical protein
I6G73_RS15785	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G73_RS15795	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G73_RS15815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G73_RS15825	COG2431	L-lysine efflux transmembrane transporter activity
I6G73_RS15830	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G73_RS15835	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I6G73_RS15850	COG1393	Belongs to the ArsC family
I6G73_RS15860	COG4783	chaperone-mediated protein folding
I6G73_RS15865	COG0425	Belongs to the sulfur carrier protein TusA family
I6G73_RS15890	COG3842	ATPase activity
I6G73_RS15895	COG3833	ABC-type maltose transport systems, permease component
I6G73_RS15900	COG1175	transmembrane transport
I6G73_RS15910	COG3081	Nucleoid-associated protein
I6G73_RS15915	COG3082	Protein of unknown function (DUF1414)
I6G73_RS15920	COG3083	sulfuric ester hydrolase activity
I6G73_RS15925	COG4771	TonB-dependent receptor
I6G73_RS15930	COG1770	oligopeptidase
I6G73_RS15950	COG4574	serine-type endopeptidase inhibitor activity
I6G73_RS15955	COG3085	chromosome segregation
I6G73_RS15960	COG0583	DNA-binding transcription factor activity
I6G73_RS15965	COG0287	Prephenate dehydrogenase
I6G73_RS15965	COG1605	Chorismate mutase
I6G73_RS15970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G73_RS15975	COG0584	glycerophosphoryl diester phosphodiesterase
I6G73_RS15985	COG1349	DNA-binding transcription factor activity
I6G73_RS15990	COG2271	Major facilitator Superfamily
I6G73_RS15995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G73_RS16000	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6G73_RS16005	COG0583	DNA-binding transcription factor activity
I6G73_RS16025	COG0656	L-ascorbic acid biosynthetic process
I6G73_RS16030	COG2814	Major facilitator Superfamily
I6G73_RS16040	COG1294	oxidase, subunit
I6G73_RS16045	COG1271	oxidase subunit
I6G73_RS16050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G73_RS16060	COG2979	Protein of unknown function (DUF533)
I6G73_RS16085	COG2271	Major facilitator Superfamily
I6G73_RS16090	COG0583	DNA-binding transcription factor activity
I6G73_RS16100	COG2807	transmembrane transport
I6G73_RS16110	COG1187	pseudouridine synthase activity
I6G73_RS16125	COG0346	lactoylglutathione lyase activity
I6G73_RS16160	COG2964	Protein conserved in bacteria
I6G73_RS16165	COG3681	Belongs to the UPF0597 family
I6G73_RS16175	COG0814	amino acid
I6G73_RS16195	COG1166	arginine decarboxylase activity
I6G73_RS16205	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G73_RS16235	COG0583	DNA-binding transcription factor activity
I6G73_RS16245	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6G73_RS16250	COG0840	transmembrane signaling receptor activity
I6G73_RS16255	COG0302	gtp cyclohydrolase
I6G73_RS16265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G73_RS16295	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6G73_RS16310	COG0314	molybdopterin synthase activity
I6G73_RS16315	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6G73_RS16320	COG0315	cyclic pyranopterin monophosphate synthase activity
I6G73_RS16325	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G73_RS16330	COG3005	denitrification pathway
I6G73_RS16340	COG0348	domain, Protein
I6G73_RS16345	COG0437	4 iron, 4 sulfur cluster binding
I6G73_RS16350	COG0243	molybdopterin cofactor binding
I6G73_RS16360	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G73_RS16360	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G73_RS16365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G73_RS16370	COG3850	Histidine kinase
I6G73_RS16375	COG2197	response regulator
I6G73_RS16405	COG0121	glutamine amidotransferase
I6G73_RS16410	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6G73_RS16415	COG1960	acyl-CoA dehydrogenase activity
I6G73_RS16420	COG0784	Response regulator, receiver
I6G73_RS16420	COG3437	response regulator, receiver
I6G73_RS16435	COG0328	RNA-DNA hybrid ribonuclease activity
I6G73_RS16440	COG2226	methyltransferase
I6G73_RS16445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G73_RS16450	COG1388	LysM domain
I6G73_RS16450	COG0741	lytic transglycosylase activity
I6G73_RS16455	COG3021	interspecies interaction between organisms
I6G73_RS16465	COG1607	acyl-coa hydrolase
I6G73_RS16480	COG0741	lytic transglycosylase activity
I6G73_RS16490	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6G73_RS16515	COG0729	surface antigen
I6G73_RS16525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G73_RS16530	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G73_RS16540	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G73_RS16550	COG4134	Bacterial extracellular solute-binding protein
I6G73_RS16560	COG4136	ATPase activity
I6G73_RS16565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G73_RS16570	COG2951	lytic endotransglycosylase activity
I6G73_RS16575	COG1846	Transcriptional regulator
I6G73_RS16585	COG0033	Phosphoglucomutase
I6G73_RS16590	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6G73_RS16595	COG0596	Alpha beta hydrolase
I6G73_RS16610	COG0716	FMN binding
I6G73_RS16620	COG0735	belongs to the Fur family
I6G73_RS16625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G73_RS16635	COG1263	PTS System
I6G73_RS16635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G73_RS16635	COG2190	(PTS) system
I6G73_RS16640	COG0363	glucosamine-6-phosphate deaminase activity
I6G73_RS16645	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G73_RS16650	COG1940	carbohydrate kinase activity
I6G73_RS16650	COG1846	Transcriptional regulator
I6G73_RS16655	COG2194	sulfuric ester hydrolase activity
I6G73_RS16660	COG0217	transcriptional regulatory protein
I6G73_RS16665	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6G73_RS16670	COG1801	Protein of unknown function DUF72
I6G73_RS16675	COG4106	trans-aconitate 2-methyltransferase activity
I6G73_RS16680	COG0500	methyltransferase
I6G73_RS16700	COG0450	alkyl hydroperoxide reductase
I6G73_RS16705	COG0583	DNA-binding transcription factor activity
I6G73_RS16715	COG0791	NLP P60 protein
I6G73_RS16730	COG1309	transcriptional regulator
I6G73_RS16770	COG0534	Mate efflux family protein
I6G73_RS16790	COG2366	antibiotic biosynthetic process
I6G73_RS16795	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6G73_RS16795	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6G73_RS16795	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6G73_RS16795	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6G73_RS16805	COG0633	Ferredoxin
I6G73_RS16805	COG3217	Mosc domain protein beta barrel domain protein
I6G73_RS16805	COG0633	Ferredoxin
I6G73_RS16805	COG3217	Mosc domain protein beta barrel domain protein
I6G73_RS16815	COG0501	Belongs to the peptidase M48B family
I6G73_RS16820	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6G73_RS16825	COG2226	methyltransferase
I6G73_RS16825	COG1073	alpha beta
I6G73_RS16830	COG0156	8-amino-7-oxononanoate synthase activity
I6G73_RS16835	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6G73_RS16855	COG0017	Asparaginyl-tRNA synthetase
I6G73_RS16860	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6G73_RS16875	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G73_RS16885	COG0583	DNA-binding transcription factor activity
I6G73_RS16890	COG1393	Belongs to the ArsC family
I6G73_RS16895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G73_RS16900	COG1876	peptidase activity
I6G73_RS16910	COG3263	regulation of cellular component size
I6G73_RS16920	COG3263	regulation of cellular component size
I6G73_RS16930	COG1280	lysine exporter protein (LysE YggA)
I6G73_RS16960	COG0564	pseudouridine synthase activity
I6G73_RS16970	COG1454	alcohol dehydrogenase
I6G73_RS16975	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G73_RS16980	COG0702	epimerase
I6G73_RS16985	COG2914	Belongs to the UPF0125 (RnfH) family
I6G73_RS16990	COG2867	negative regulation of translational initiation
I6G73_RS16995	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6G73_RS17030	COG0583	DNA-binding transcription factor activity
I6G73_RS17035	COG3048	D-serine ammonia-lyase activity
I6G73_RS17045	COG0538	isocitrate dehydrogenase activity
I6G73_RS17050	COG2207	Transcriptional regulator
I6G73_RS17070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G73_RS17085	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6G73_RS17090	COG1263	PTS System
I6G73_RS17090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G73_RS17095	COG1609	Transcriptional regulator
I6G73_RS17105	COG0456	acetyltransferase
I6G73_RS17125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G73_RS17125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G73_RS17125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G73_RS17130	COG5599	Phosphatase
I6G73_RS17145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G73_RS17145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G73_RS17145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G73_RS17155	COG1187	pseudouridine synthase activity
I6G73_RS17165	COG0482	sulfurtransferase activity
I6G73_RS17170	COG2915	High frequency lysogenization protein hflD homolog
I6G73_RS17175	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G73_RS17180	COG2850	peptidyl-arginine hydroxylation
I6G73_RS17190	COG3153	acetyltransferase
I6G73_RS17200	COG0625	glutathione transferase activity
I6G73_RS17205	COG0259	pyridoxamine-phosphate oxidase activity
I6G73_RS17220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G73_RS17220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G73_RS17225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6G73_RS17240	COG4235	cytochrome complex assembly
I6G73_RS17240	COG3088	subunit of a heme lyase
I6G73_RS17245	COG3088	subunit of a heme lyase
I6G73_RS17245	COG4235	cytochrome complex assembly
I6G73_RS17250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G73_RS17255	COG1138	Cytochrome C-type biogenesis protein
I6G73_RS17260	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6G73_RS17265	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G73_RS17270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G73_RS17275	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G73_RS17290	COG0835	chemotaxis
I6G73_RS17305	COG1360	Flagellar Motor Protein
I6G73_RS17310	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6G73_RS17315	COG2201	protein-glutamate methylesterase activity
I6G73_RS17320	COG2198	Histidine kinase
I6G73_RS17320	COG0643	Histidine kinase
I6G73_RS17320	COG0784	Response regulator, receiver
I6G73_RS17325	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6G73_RS17350	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6G73_RS17360	COG1684	flagellar biosynthetic protein fliR
I6G73_RS17415	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G73_RS17425	COG1677	Flagellar hook-basal body complex protein FliE
I6G73_RS17440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G73_RS17460	COG1737	Transcriptional regulator
I6G73_RS17465	COG0469	pyruvate kinase activity
I6G73_RS17475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G73_RS17480	COG1960	acyl-CoA dehydrogenase activity
I6G73_RS17490	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6G73_RS17530	COG0243	molybdopterin cofactor binding
I6G73_RS17535	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6G73_RS17540	COG0583	DNA-binding transcription factor activity
I6G73_RS17575	COG1454	alcohol dehydrogenase
I6G73_RS17575	COG1012	belongs to the aldehyde dehydrogenase family
I6G73_RS17585	COG1012	belongs to the aldehyde dehydrogenase family
I6G73_RS17585	COG1454	alcohol dehydrogenase
I6G73_RS17590	COG1882	Formate acetyltransferase
I6G73_RS17595	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G73_RS17605	COG4869	propanediol catabolic process
I6G73_RS17630	COG1388	LysM domain
I6G73_RS17630	COG1376	ErfK ybiS ycfS ynhG family protein
I6G73_RS17645	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6G73_RS17650	COG0791	NLP P60 protein
I6G73_RS17655	COG2091	lysine biosynthetic process via aminoadipic acid
I6G73_RS17660	COG3118	belongs to the thioredoxin family
I6G73_RS17670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6G73_RS17675	COG0788	formyltetrahydrofolate deformylase activity
I6G73_RS17685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G73_RS17705	COG0366	Alpha amylase catalytic
I6G73_RS17710	COG0739	heme binding
I6G73_RS17710	COG0741	lytic transglycosylase activity
I6G73_RS17710	COG1196	nuclear chromosome segregation
I6G73_RS17715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G73_RS17720	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6G73_RS17730	COG0673	inositol 2-dehydrogenase activity
I6G73_RS17780	COG1032	radical SAM domain protein
I6G73_RS17790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G73_RS17795	COG1566	PFAM secretion protein HlyD family protein
I6G73_RS17805	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6G73_RS17810	COG0733	neurotransmitter:sodium symporter activity
I6G73_RS17840	COG0281	malic enzyme
I6G73_RS17850	COG0534	Mate efflux family protein
I6G73_RS17865	COG2233	PERMEase
I6G73_RS17870	COG0095	Lipoate-protein ligase
I6G73_RS17875	COG1115	amino acid carrier protein
I6G73_RS17880	COG0019	diaminopimelate decarboxylase activity
I6G73_RS17890	COG0678	peroxiredoxin activity
I6G73_RS17900	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6G73_RS17920	COG1131	(ABC) transporter
I6G73_RS17925	COG0545	Peptidyl-prolyl cis-trans isomerase
I6G73_RS17935	COG3142	Participates in the control of copper homeostasis
I6G73_RS17960	COG5002	protein histidine kinase activity
I6G73_RS17965	COG0745	RESPONSE REGULATOR receiver
I6G73_RS17970	COG0346	lactoylglutathione lyase activity
I6G73_RS17975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G73_RS17980	COG1960	acyl-CoA dehydrogenase activity
I6G73_RS17985	COG3284	Transcriptional regulator
I6G73_RS18000	COG0697	spore germination
I6G73_RS18020	COG4565	transcriptional regulatory protein
I6G73_RS18025	COG3290	protein histidine kinase activity
I6G73_RS18030	COG0281	malic enzyme
I6G73_RS18040	COG1846	Transcriptional regulator
I6G73_RS18045	COG1566	PFAM secretion protein HlyD family protein
I6G73_RS18075	COG0602	queuosine metabolic process
I6G73_RS18080	COG1328	CTP reductase activity
I6G73_RS18090	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6G73_RS18095	COG3115	cell septum assembly
I6G73_RS18100	COG1196	nuclear chromosome segregation
I6G73_RS18110	COG2860	membrane
I6G73_RS18120	COG3108	Peptidase M15
I6G73_RS18125	COG2989	Protein conserved in bacteria
I6G73_RS18140	COG0463	Glycosyl transferase, family 2
I6G73_RS18155	COG0366	Alpha amylase catalytic
I6G73_RS18195	COG3706	GGDEF domain
I6G73_RS18205	COG3590	peptidase
I6G73_RS18215	COG0488	(ABC) transporter
I6G73_RS18225	COG0531	amino acid
I6G73_RS18240	COG0814	amino acid
I6G73_RS18255	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6G73_RS18260	COG1982	Orn Lys Arg decarboxylase major
I6G73_RS18265	COG0531	amino acid
I6G73_RS18270	COG3710	Transcriptional regulator
I6G73_RS18275	COG0825	malonyl-CoA metabolic process
I6G73_RS18285	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6G73_RS18290	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G73_RS18295	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G73_RS18300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G73_RS18305	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G73_RS18320	COG0750	zinc metalloprotease
I6G73_RS18325	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6G73_RS18330	COG0575	Belongs to the CDS family
I6G73_RS18335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G73_RS18340	COG0233	cytoplasmic translational termination
I6G73_RS18345	COG0528	UMP kinase activity
I6G73_RS18350	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6G73_RS18355	COG0052	Belongs to the universal ribosomal protein uS2 family
I6G73_RS18360	COG0024	Methionine aminopeptidase
I6G73_RS18365	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6G73_RS18370	COG2171	N-acyltransferase activity
I6G73_RS18380	COG1263	PTS System
I6G73_RS18380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G73_RS18400	COG0564	pseudouridine synthase activity
I6G73_RS18405	COG3098	single-species biofilm formation
I6G73_RS18430	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
I6G73_RS18440	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6G73_RS18440	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6G73_RS18455	COG1611	Belongs to the LOG family
I6G73_RS18460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G73_RS18465	COG0473	3-isopropylmalate dehydrogenase activity
I6G73_RS18475	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6G73_RS18480	COG2363	Small membrane protein
I6G73_RS18490	COG0583	DNA-binding transcription factor activity
I6G73_RS18495	COG0840	transmembrane signaling receptor activity
I6G73_RS18500	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G73_RS18515	COG1477	protein flavinylation
I6G73_RS18520	COG2871	sodium ion transport
I6G73_RS18525	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6G73_RS18530	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6G73_RS18535	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6G73_RS18540	COG1805	sodium ion transport
I6G73_RS18545	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6G73_RS18550	COG0271	Belongs to the BolA IbaG family
I6G73_RS18555	COG2813	Specifically methylates the guanine in position
I6G73_RS18565	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G73_RS18575	COG2211	Major facilitator Superfamily
I6G73_RS18580	COG3248	Nucleoside-binding outer membrane protein
I6G73_RS18585	COG1666	GTP binding
I6G73_RS18590	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6G73_RS18595	COG0693	protein deglycase activity
I6G73_RS18635	COG4104	PAAR repeat-containing protein
I6G73_RS18650	COG2771	luxR family
I6G73_RS18660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G73_RS18660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6G73_RS18665	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G73_RS18675	COG1151	hydroxylamine reductase activity
I6G73_RS18680	COG0783	Belongs to the Dps family
I6G73_RS18705	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6G73_RS18720	COG4221	oxidoreductase activity
I6G73_RS18730	COG0415	Belongs to the DNA photolyase family
I6G73_RS18735	COG0789	Transcriptional regulator
I6G73_RS18740	COG3272	Protein of unknown function (DUF1722)
I6G73_RS18770	COG0077	Prephenate dehydratase
I6G73_RS18770	COG1605	Chorismate mutase
I6G73_RS18805	COG0840	transmembrane signaling receptor activity
I6G73_RS18815	COG0300	oxidoreductase activity
I6G73_RS18840	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6G73_RS18870	COG0826	peptidase U32
I6G73_RS18875	COG1280	lysine exporter protein (LysE YggA)
I6G73_RS18885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G73_RS18890	COG0840	transmembrane signaling receptor activity
I6G73_RS18905	COG0643	Histidine kinase
I6G73_RS18905	COG2198	Histidine kinase
I6G73_RS18915	COG0835	chemotaxis
I6G73_RS18920	COG0840	transmembrane signaling receptor activity
I6G73_RS18930	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I6G73_RS18935	COG2201	protein-glutamate methylesterase activity
I6G73_RS18940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G73_RS18965	COG2200	EAL domain
I6G73_RS18965	COG2203	Gaf domain
I6G73_RS18965	COG2199	diguanylate cyclase activity
I6G73_RS18970	COG0826	peptidase U32
I6G73_RS18975	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G73_RS18980	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G73_RS18985	COG0305	Participates in initiation and elongation during chromosome replication
I6G73_RS18995	COG2200	EAL domain
I6G73_RS19000	COG0737	Belongs to the 5'-nucleotidase family
I6G73_RS19020	COG2204	response regulator
I6G73_RS19025	COG0545	Peptidyl-prolyl cis-trans isomerase
I6G73_RS19040	COG1047	Peptidyl-prolyl cis-trans
I6G73_RS19045	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6G73_RS19055	COG0784	Response regulator, receiver
I6G73_RS19055	COG0835	chemotaxis
I6G73_RS19060	COG0429	hydrolase of the alpha beta-hydrolase fold
I6G73_RS19065	COG3706	GGDEF domain
I6G73_RS19065	COG2203	Gaf domain
I6G73_RS19065	COG5001	Diguanylate cyclase
I6G73_RS19065	COG4251	negative regulation of phosphorylation
I6G73_RS19070	COG3089	Belongs to the UPF0270 family
I6G73_RS19080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G73_RS19085	COG0463	Glycosyl transferase, family 2
I6G73_RS19090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G73_RS19090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6G73_RS19095	COG0726	polysaccharide deacetylase
I6G73_RS19100	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6G73_RS19105	COG2076	Multidrug Resistance protein
I6G73_RS19110	COG2076	Multidrug Resistance protein
I6G73_RS19115	COG3954	Phosphoribulokinase
I6G73_RS19130	COG1765	OsmC-like protein
I6G73_RS19145	COG3397	chitin binding
I6G73_RS19160	COG2205	protein histidine kinase activity
I6G73_RS19160	COG2202	Pas domain
I6G73_RS19170	COG3655	Transcriptional regulator
I6G73_RS19175	COG2814	Major facilitator Superfamily
I6G73_RS19180	COG4771	TonB-dependent receptor
I6G73_RS19200	COG0748	coenzyme F420 binding
I6G73_RS19205	COG3721	Heme iron utilization protein
I6G73_RS19215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G73_RS19240	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6G73_RS19245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G73_RS19250	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6G73_RS19270	COG0741	lytic transglycosylase activity
I6G73_RS19275	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G73_RS19290	COG0488	(ABC) transporter
I6G73_RS19300	COG2252	PERMEase
I6G73_RS19305	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6G73_RS19310	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6G73_RS19315	COG3178	'Phosphotransferase
I6G73_RS19320	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6G73_RS19330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6G73_RS19335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6G73_RS19340	COG2967	ApaG domain
I6G73_RS19345	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6G73_RS19355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G73_RS19360	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6G73_RS19375	COG0318	PFAM AMP-dependent synthetase and ligase
I6G73_RS19380	COG3314	Sporulation integral membrane protein YlbJ
I6G73_RS19385	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6G73_RS19390	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6G73_RS19395	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6G73_RS19400	COG0142	geranyltranstransferase activity
I6G73_RS19405	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6G73_RS19410	COG0330	HflC and HflK could
I6G73_RS19415	COG0330	HflC and HflK could
I6G73_RS19420	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G73_RS19425	COG1923	regulation of RNA biosynthetic process
I6G73_RS19430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6G73_RS19435	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6G73_RS19445	COG0802	atpase or kinase
I6G73_RS19450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6G73_RS19450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6G73_RS19455	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6G73_RS19470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G73_RS19475	COG2011	ABC-type metal ion transport system permease component
I6G73_RS19480	COG1464	Belongs to the NlpA lipoprotein family
I6G73_RS19490	COG0840	transmembrane signaling receptor activity
I6G73_RS19515	COG0784	Response regulator, receiver
I6G73_RS19515	COG5002	protein histidine kinase activity
I6G73_RS19515	COG2198	Histidine kinase
I6G73_RS19535	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I6G73_RS19550	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6G73_RS19555	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6G73_RS19565	COG2716	regulation of RNA biosynthetic process
I6G73_RS19570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6G73_RS19575	COG3013	Belongs to the UPF0304 family
I6G73_RS19585	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6G73_RS19590	COG0280	phosphate acetyltransferase
I6G73_RS19590	COG0857	belongs to the CobB CobQ family
I6G73_RS19600	COG0028	Belongs to the TPP enzyme family
I6G73_RS19610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6G73_RS19615	COG0671	phosphoesterase, PA-phosphatase related
I6G73_RS19625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G73_RS19630	COG0473	3-isopropylmalate dehydrogenase activity
I6G73_RS19635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6G73_RS19640	COG0066	3-isopropylmalate dehydratase activity
I6G73_RS19655	COG4143	(ABC) transporter
I6G73_RS19665	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6G73_RS19670	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6G73_RS19710	COG0316	Belongs to the HesB IscA family
I6G73_RS19720	COG0038	chloride channel
I6G73_RS19725	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6G73_RS19740	COG0671	phosphoesterase, PA-phosphatase related
I6G73_RS19750	COG0784	Response regulator, receiver
I6G73_RS19750	COG3437	response regulator, receiver
I6G73_RS19760	COG2076	Multidrug Resistance protein
I6G73_RS19770	COG0346	lactoylglutathione lyase activity
I6G73_RS19775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G73_RS19780	COG1643	Atp-dependent helicase
I6G73_RS19790	COG1489	DNA binding
I6G73_RS19795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6G73_RS19800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G73_RS19815	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6G73_RS19820	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6G73_RS19840	COG1924	4 iron, 4 sulfur cluster binding
I6G73_RS19845	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6G73_RS19850	COG0842	Transport permease protein
I6G73_RS19855	COG1131	(ABC) transporter
I6G73_RS19870	COG0163	prenyltransferase activity
I6G73_RS19875	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G73_RS19880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6G73_RS19895	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6G73_RS19910	COG1136	(ABC) transporter
I6G73_RS19930	COG0840	transmembrane signaling receptor activity
I6G73_RS19935	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6G73_RS19940	COG0529	Catalyzes the synthesis of activated sulfate
I6G73_RS19945	COG3273	potassium ion transport
I6G73_RS19945	COG0471	metal ion transport
I6G73_RS19950	COG2895	sulfate adenylyltransferase (ATP) activity
I6G73_RS19955	COG0175	sulfate reduction
I6G73_RS19960	COG1648	precorrin-2 dehydrogenase activity
I6G73_RS19960	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G73_RS19965	COG0330	HflC and HflK could
I6G73_RS19970	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6G73_RS19975	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6G73_RS19975	COG0517	IMP dehydrogenase activity
I6G73_RS19980	COG0488	(ABC) transporter
I6G73_RS19990	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6G73_RS19995	COG0583	DNA-binding transcription factor activity
I6G73_RS20030	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G73_RS20040	COG0668	transmembrane transport
I6G73_RS20050	COG2731	YhcH YjgK YiaL family protein
I6G73_RS20065	COG1794	racemase activity, acting on amino acids and derivatives
I6G73_RS20080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G73_RS20105	COG0733	neurotransmitter:sodium symporter activity
I6G73_RS20115	COG0733	neurotransmitter:sodium symporter activity
I6G73_RS20130	COG0561	phosphatase activity
I6G73_RS20160	COG1846	Transcriptional regulator
I6G73_RS20165	COG1764	response to oxidative stress
I6G73_RS20170	COG2130	NADP-dependent
I6G73_RS20175	COG1051	belongs to the nudix hydrolase family
I6G73_RS20195	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6G73_RS20200	COG1640	4-alpha-glucanotransferase
I6G73_RS20205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G73_RS20210	COG0676	glucose-6-phosphate 1-epimerase activity
I6G73_RS20215	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6G73_RS20220	COG0840	transmembrane signaling receptor activity
I6G73_RS20295	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6G73_RS20300	COG2885	chlorophyll binding
I6G73_RS20305	COG0823	Involved in the tonB-independent uptake of proteins
I6G73_RS20320	COG0811	peptide transport
I6G73_RS20325	COG0824	Thioesterase
I6G73_RS20330	COG3790	cyd operon protein YbgE
I6G73_RS20335	COG4890	Cyd operon protein YbgT
I6G73_RS20340	COG1294	oxidase, subunit
I6G73_RS20345	COG1271	oxidase subunit
I6G73_RS20350	COG2255	four-way junction helicase activity
I6G73_RS20355	COG0632	four-way junction helicase activity
I6G73_RS20360	COG0840	transmembrane signaling receptor activity
I6G73_RS20365	COG0442	prolyl-tRNA aminoacylation
I6G73_RS20370	COG4221	oxidoreductase activity
I6G73_RS20385	COG1024	Enoyl-CoA hydratase
I6G73_RS20405	COG4166	transmembrane transport
I6G73_RS20420	COG1872	DUF167
I6G73_RS20425	COG0762	integral membrane protein
I6G73_RS20430	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G73_RS20435	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6G73_RS20450	COG3022	response to hydroperoxide
I6G73_RS20455	COG0513	Belongs to the DEAD box helicase family
I6G73_RS20460	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6G73_RS20485	COG0735	belongs to the Fur family
I6G73_RS20490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G73_RS20505	COG0776	regulation of translation
I6G73_RS20515	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6G73_RS20540	COG0560	Phosphoserine phosphatase
I6G73_RS20550	COG3447	MASE1 domain protein
I6G73_RS20550	COG5001	Diguanylate cyclase
I6G73_RS20550	COG5002	protein histidine kinase activity
I6G73_RS20555	COG0813	purine-nucleoside phosphorylase activity
I6G73_RS20560	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6G73_RS20565	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6G73_RS20570	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6G73_RS20580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G73_RS20585	COG0084	hydrolase, TatD family'
I6G73_RS20590	COG2165	general secretion pathway protein
I6G73_RS20600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G73_RS20605	COG0004	ammonium transporteR
I6G73_RS20610	COG4974	Belongs to the 'phage' integrase family
I6G73_RS20620	COG2932	Transcriptional regulator
I6G73_RS20700	COG4695	Portal protein
I6G73_RS20840	COG0795	lipopolysaccharide-transporting ATPase activity
I6G73_RS20845	COG0795	lipopolysaccharide-transporting ATPase activity
I6G73_RS20850	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6G73_RS20855	COG2927	DNA polymerase III (CHI subunit)
I6G73_RS20860	COG0525	valine-tRNA ligase activity
I6G73_RS20865	COG1253	flavin adenine dinucleotide binding
I6G73_RS20870	COG0586	Pfam SNARE associated Golgi protein
I6G73_RS20875	COG1686	Belongs to the peptidase S11 family
I6G73_RS20910	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6G73_RS20915	COG0527	aspartate kinase activity
I6G73_RS20920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G73_RS20930	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6G73_RS20935	COG1546	Belongs to the CinA family
I6G73_RS20940	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6G73_RS20960	COG3068	Protein conserved in bacteria
I6G73_RS20970	COG0739	heme binding
I6G73_RS20990	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6G73_RS20995	COG1121	(ABC) transporter
I6G73_RS21000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G73_RS21005	COG0583	DNA-binding transcription factor activity
I6G73_RS21010	COG0697	spore germination
I6G73_RS21015	COG1573	uracil-dna glycosylase
I6G73_RS21020	COG2962	Rard protein
I6G73_RS21030	COG2827	Endonuclease containing a URI domain
I6G73_RS21045	COG1842	Phage shock protein A
I6G73_RS21050	COG0204	Acyl-transferase
I6G73_RS21075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G73_RS21120	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6G73_RS21135	COG1289	transmembrane transporter activity
I6G73_RS21140	COG1566	PFAM secretion protein HlyD family protein
I6G73_RS21155	COG1051	belongs to the nudix hydrolase family
I6G73_RS21160	COG3150	esterase
I6G73_RS21170	COG3151	Protein conserved in bacteria
I6G73_RS21175	COG0494	nUDIX hydrolase
I6G73_RS21180	COG1538	Outer membrane efflux protein
I6G73_RS21185	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6G73_RS21185	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6G73_RS21190	COG1560	Kdo2-lipid A biosynthetic process
I6G73_RS21205	COG1392	Phosphate transport regulator
I6G73_RS21210	COG0306	phosphate transporter
I6G73_RS21215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G73_RS21245	COG0583	DNA-binding transcription factor activity
I6G73_RS21250	COG1380	Effector of murein hydrolase LrgA
I6G73_RS21255	COG1346	cytolysis
I6G73_RS21270	COG0617	tRNA 3'-terminal CCA addition
I6G73_RS21275	COG3267	Type II secretory pathway component ExeA
I6G73_RS21275	COG3409	Peptidoglycan-binding domain 1 protein
I6G73_RS21285	COG1194	a g-specific adenine glycosylase
I6G73_RS21290	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6G73_RS21300	COG3111	PFAM Bacterial OB fold (BOF) protein
I6G73_RS21305	COG3240	lipase activity
I6G73_RS21315	COG2885	chlorophyll binding
I6G73_RS21315	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6G73_RS21320	COG3009	Protein conserved in bacteria
I6G73_RS21325	COG3008	intermembrane lipid transfer
I6G73_RS21325	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G73_RS21330	COG2995	paraquat-inducible protein a
I6G73_RS21340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G73_RS21350	COG5001	Diguanylate cyclase
I6G73_RS21350	COG3706	GGDEF domain
I6G73_RS21350	COG4251	negative regulation of phosphorylation
I6G73_RS21350	COG2203	Gaf domain
I6G73_RS21355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G73_RS21360	COG2813	Specifically methylates the guanine in position
I6G73_RS21365	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6G73_RS21370	COG0297	glycogen (starch) synthase activity
I6G73_RS21410	COG1757	Na H antiporter
I6G73_RS21415	COG0583	DNA-binding transcription factor activity
I6G73_RS21420	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6G73_RS21425	COG3842	ATPase activity
I6G73_RS21430	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G73_RS21435	COG1177	transmembrane transport
I6G73_RS21440	COG1012	belongs to the aldehyde dehydrogenase family
I6G73_RS21450	COG5006	permease, DMT superfamily
I6G73_RS21455	COG1522	sequence-specific DNA binding
I6G73_RS21460	COG0110	maltose O-acetyltransferase activity
I6G73_RS21465	COG0366	Alpha amylase catalytic
I6G73_RS21470	COG1263	PTS System
I6G73_RS21470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G73_RS21490	COG0252	asparaginase activity
I6G73_RS21505	COG1803	Methylglyoxal synthase
I6G73_RS21530	COG1444	tRNA N-acetyltransferase activity
I6G73_RS21545	COG0835	chemotaxis
I6G73_RS21545	COG0784	Response regulator, receiver
I6G73_RS21550	COG3314	Sporulation integral membrane protein YlbJ
I6G73_RS21590	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6G73_RS21595	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G73_RS21610	COG0477	Major facilitator Superfamily
I6G73_RS21615	COG0523	cobalamin synthesis protein
I6G73_RS21625	COG1280	lysine exporter protein (LysE YggA)
I6G73_RS21635	COG2200	EAL domain
I6G73_RS21640	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6G73_RS21645	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6G73_RS21650	COG0840	transmembrane signaling receptor activity
I6G73_RS21655	COG0840	transmembrane signaling receptor activity
I6G73_RS21665	COG5002	protein histidine kinase activity
I6G73_RS21665	COG3447	MASE1 domain protein
I6G73_RS21665	COG5001	Diguanylate cyclase
I6G73_RS21670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G73_RS21675	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G73_RS21680	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6G73_RS21685	COG2186	Transcriptional regulator
I6G73_RS21710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G73_RS21715	COG1459	type II secretion system
I6G73_RS21730	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6G73_RS21735	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6G73_RS21740	COG0494	nUDIX hydrolase
I6G73_RS21750	COG0653	protein targeting
I6G73_RS21760	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6G73_RS21765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6G73_RS21770	COG0849	cell division
I6G73_RS21775	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6G73_RS21780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G73_RS21785	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6G73_RS21790	COG0772	Belongs to the SEDS family
I6G73_RS21795	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6G73_RS21800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G73_RS21805	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G73_RS21815	COG0768	penicillin binding
I6G73_RS21820	COG3116	cell division
I6G73_RS21825	COG0275	rRNA processing
I6G73_RS21830	COG2001	Belongs to the MraZ family
I6G73_RS21840	COG0741	lytic transglycosylase activity
I6G73_RS21840	COG1388	LysM domain
I6G73_RS21845	COG1360	Flagellar Motor Protein
I6G73_RS21850	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6G73_RS21855	COG1191	sigma factor activity
I6G73_RS21880	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6G73_RS21885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6G73_RS21905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6G73_RS21910	COG4786	Flagellar basal body rod
I6G73_RS21910	COG1256	bacterial-type flagellum assembly
I6G73_RS21920	COG1706	bacterial-type flagellum-dependent cell motility
I6G73_RS21925	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6G73_RS21930	COG4786	Flagellar basal body rod