locus-tag	class	description
IFA22_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IFA22_RS00010	COG0592	DNA-directed DNA polymerase activity
IFA22_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IFA22_RS00030	COG2378	regulation of single-species biofilm formation
IFA22_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
IFA22_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
IFA22_RS00045	COG3977	Valine--pyruvate aminotransferase
IFA22_RS00060	COG2814	Major facilitator Superfamily
IFA22_RS00065	COG0745	RESPONSE REGULATOR receiver
IFA22_RS00070	COG2205	protein histidine kinase activity
IFA22_RS00090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IFA22_RS00095	COG4191	Histidine kinase
IFA22_RS00095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IFA22_RS00100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IFA22_RS00105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IFA22_RS00140	COG0469	pyruvate kinase activity
IFA22_RS00145	COG2271	Major facilitator Superfamily
IFA22_RS00170	COG0561	phosphatase activity
IFA22_RS00175	COG2267	carboxylic ester hydrolase activity
IFA22_RS00180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IFA22_RS00185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IFA22_RS00190	COG1758	RNA polymerase activity
IFA22_RS00200	COG0859	PFAM glycosyl transferase family 9
IFA22_RS00205	COG3642	lipopolysaccharide core region biosynthetic process
IFA22_RS00245	COG0589	response to stress
IFA22_RS00250	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IFA22_RS00260	COG1528	Iron-storage protein
IFA22_RS00265	COG2081	HI0933 family
IFA22_RS00270	COG2223	nitrite transmembrane transporter activity
IFA22_RS00290	COG3188	usher protein
IFA22_RS00310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IFA22_RS00310	COG2205	protein histidine kinase activity
IFA22_RS00320	COG3275	phosphorelay sensor kinase activity
IFA22_RS00325	COG3279	Response regulator of the LytR AlgR family
IFA22_RS00330	COG2223	nitrite transmembrane transporter activity
IFA22_RS00335	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IFA22_RS00340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IFA22_RS00355	COG0583	DNA-binding transcription factor activity
IFA22_RS00365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IFA22_RS00400	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IFA22_RS00405	COG2166	iron-sulfur cluster assembly
IFA22_RS00410	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IFA22_RS00415	COG0210	DNA helicase
IFA22_RS00425	COG3245	cytochrome
IFA22_RS00430	COG1063	alcohol dehydrogenase
IFA22_RS00435	COG0156	8-amino-7-oxononanoate synthase activity
IFA22_RS00445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IFA22_RS00460	COG3306	glycosyltransferase involved in LPS biosynthesis
IFA22_RS00480	COG1561	YicC-like family, N-terminal region
IFA22_RS00485	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IFA22_RS00490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IFA22_RS00500	COG0789	Transcriptional regulator
IFA22_RS00505	COG2203	Gaf domain
IFA22_RS00505	COG4251	negative regulation of phosphorylation
IFA22_RS00505	COG3706	GGDEF domain
IFA22_RS00505	COG5001	Diguanylate cyclase
IFA22_RS00510	COG3084	Protein conserved in bacteria
IFA22_RS00520	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IFA22_RS00525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IFA22_RS00535	COG1335	isochorismatase
IFA22_RS00545	COG1683	Conserved Protein
IFA22_RS00550	COG0204	Acyl-transferase
IFA22_RS00555	COG0204	Acyl-transferase
IFA22_RS00560	COG0606	chelatase, subunit chli
IFA22_RS00570	COG3978	acetolactate synthase activity
IFA22_RS00580	COG0129	dihydroxy-acid dehydratase activity
IFA22_RS00600	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IFA22_RS00605	COG0254	rRNA binding
IFA22_RS00610	COG0702	epimerase
IFA22_RS00615	COG0281	malic enzyme
IFA22_RS00625	COG2205	protein histidine kinase activity
IFA22_RS00630	COG0745	RESPONSE REGULATOR receiver
IFA22_RS00635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IFA22_RS00670	COG4310	Domain of unknown function (DUF2172)
IFA22_RS00685	COG2089	acid synthase
IFA22_RS00695	COG1083	cytidylyl-transferase
IFA22_RS00710	COG1028	Short-chain dehydrogenase reductase Sdr
IFA22_RS00715	COG0318	PFAM AMP-dependent synthetase and ligase
IFA22_RS00730	COG1215	transferase activity, transferring glycosyl groups
IFA22_RS00745	COG1216	Glycosyl transferase, family 2
IFA22_RS00755	COG1216	Glycosyl transferase, family 2
IFA22_RS00765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IFA22_RS00790	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IFA22_RS00815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IFA22_RS00820	COG1086	Polysaccharide biosynthesis protein
IFA22_RS00825	COG0366	Alpha amylase catalytic
IFA22_RS00840	COG0443	Heat shock 70 kDa protein
IFA22_RS00845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IFA22_RS00850	COG3045	CreA protein
IFA22_RS00870	COG0174	glutamine synthetase
IFA22_RS00890	COG3842	ATPase activity
IFA22_RS00895	COG1176	ABC-type spermidine putrescine transport system, permease component I
IFA22_RS00900	COG1177	transmembrane transport
IFA22_RS00905	COG2258	MOSC domain
IFA22_RS00920	COG2050	protein possibly involved in aromatic compounds catabolism
IFA22_RS00925	COG0514	ATP-dependent DNA helicase (RecQ)
IFA22_RS00935	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IFA22_RS00945	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IFA22_RS00950	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IFA22_RS00960	COG2239	Acts as a magnesium transporter
IFA22_RS00965	COG1648	precorrin-2 dehydrogenase activity
IFA22_RS00965	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IFA22_RS00970	COG2116	formate transmembrane transporter activity
IFA22_RS00985	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IFA22_RS00995	COG0477	Major facilitator Superfamily
IFA22_RS01000	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IFA22_RS01005	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IFA22_RS01025	COG1595	DNA-templated transcription, initiation
IFA22_RS01030	COG3806	Anti-sigma factor
IFA22_RS01035	COG1968	undecaprenyl-diphosphatase activity
IFA22_RS01040	COG0667	Aldo Keto reductase
IFA22_RS01045	COG2017	converts alpha-aldose to the beta-anomer
IFA22_RS01050	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IFA22_RS01060	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IFA22_RS01065	COG1609	Transcriptional regulator
IFA22_RS01070	COG3250	beta-galactosidase activity
IFA22_RS01080	COG5433	transposase activity
IFA22_RS01125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IFA22_RS01130	COG1288	antiporter activity
IFA22_RS01135	COG1438	arginine binding
IFA22_RS01140	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
IFA22_RS01145	COG0540	Belongs to the ATCase OTCase family
IFA22_RS01165	COG0688	phosphatidylethanolamine metabolic process
IFA22_RS01175	COG3040	lipid binding
IFA22_RS01180	COG2207	Transcriptional regulator
IFA22_RS01185	COG1979	alcohol dehydrogenase
IFA22_RS01190	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IFA22_RS01195	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IFA22_RS01205	COG3681	Belongs to the UPF0597 family
IFA22_RS01215	COG0446	pyridine nucleotide-disulphide oxidoreductase
IFA22_RS01220	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IFA22_RS01225	COG0564	pseudouridine synthase activity
IFA22_RS01235	COG0542	response to heat
IFA22_RS01240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IFA22_RS01245	COG2502	aspartate--ammonia ligase
IFA22_RS01250	COG1522	sequence-specific DNA binding
IFA22_RS01260	COG5413	integral membrane protein
IFA22_RS01285	COG2205	protein histidine kinase activity
IFA22_RS01295	COG2204	response regulator
IFA22_RS01310	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IFA22_RS01340	COG0243	molybdopterin cofactor binding
IFA22_RS01345	COG3005	denitrification pathway
IFA22_RS01350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IFA22_RS01355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IFA22_RS01360	COG0569	domain protein
IFA22_RS01365	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IFA22_RS01390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IFA22_RS01405	COG0250	Participates in transcription elongation, termination and antitermination
IFA22_RS01410	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IFA22_RS01415	COG0081	regulation of translation
IFA22_RS01420	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IFA22_RS01425	COG0222	ribosome binding
IFA22_RS01430	COG0085	RNA polymerase activity
IFA22_RS01435	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IFA22_RS01440	COG2964	Protein conserved in bacteria
IFA22_RS01445	COG0251	oxidation-reduction process
IFA22_RS01455	COG2923	Belongs to the DsrF TusC family
IFA22_RS01460	COG2168	tRNA wobble position uridine thiolation
IFA22_RS01465	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IFA22_RS01470	COG0049	tRNA binding
IFA22_RS01475	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IFA22_RS01480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IFA22_RS01485	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IFA22_RS01530	COG2249	NAD(P)H dehydrogenase (quinone) activity
IFA22_RS01535	COG0583	DNA-binding transcription factor activity
IFA22_RS01540	COG4221	oxidoreductase activity
IFA22_RS01555	COG1770	oligopeptidase
IFA22_RS01575	COG3714	YhhN family
IFA22_RS01600	COG1301	dicarboxylic acid transport
IFA22_RS01610	COG2095	MarC family integral membrane protein
IFA22_RS01620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IFA22_RS01630	COG0741	lytic transglycosylase activity
IFA22_RS01640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IFA22_RS01665	COG0742	ribosomal rna small subunit methyltransferase
IFA22_RS01670	COG0552	protein localization to endoplasmic reticulum
IFA22_RS01675	COG2884	Cell division ATP-binding protein ftsE
IFA22_RS01680	COG2177	Part of the ABC transporter FtsEX involved in
IFA22_RS01690	COG0288	reversible hydration of carbon dioxide
IFA22_RS01695	COG2188	Transcriptional regulator
IFA22_RS01700	COG1228	amidohydrolase
IFA22_RS01705	COG0010	Belongs to the arginase family
IFA22_RS01710	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IFA22_RS01715	COG2986	histidine ammonia-lyase
IFA22_RS01720	COG0387	Pfam Sodium calcium exchanger
IFA22_RS01725	COG2200	EAL domain
IFA22_RS01730	COG2199	diguanylate cyclase activity
IFA22_RS01730	COG2200	EAL domain
IFA22_RS01775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IFA22_RS01780	COG1459	type II secretion system
IFA22_RS01790	COG2165	general secretion pathway protein
IFA22_RS01795	COG2165	general secretion pathway protein
IFA22_RS01825	COG1077	Cell shape determining protein MreB Mrl
IFA22_RS01830	COG1792	Involved in formation and maintenance of cell shape
IFA22_RS01835	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IFA22_RS01840	COG0424	maF-like protein
IFA22_RS01845	COG1530	ribonuclease E activity
IFA22_RS01850	COG3164	Protein of unknown function
IFA22_RS01860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IFA22_RS01865	COG0312	modulator of DNA gyrase
IFA22_RS01885	COG1263	PTS System
IFA22_RS01885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IFA22_RS01890	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IFA22_RS01910	COG0477	Major facilitator Superfamily
IFA22_RS01920	COG3437	response regulator, receiver
IFA22_RS01925	COG0784	Response regulator, receiver
IFA22_RS01925	COG2205	protein histidine kinase activity
IFA22_RS01925	COG5002	protein histidine kinase activity
IFA22_RS01930	COG2172	sigma factor antagonist activity
IFA22_RS01935	COG1366	Belongs to the anti-sigma-factor antagonist family
IFA22_RS01955	COG3700	Belongs to the class B bacterial acid phosphatase family
IFA22_RS01960	COG2321	neutral zinc metallopeptidase
IFA22_RS01970	COG1639	'signal transduction protein
IFA22_RS01995	COG0189	ligase activity
IFA22_RS02005	COG0642	Histidine kinase
IFA22_RS02010	COG0745	RESPONSE REGULATOR receiver
IFA22_RS02030	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IFA22_RS02035	COG0352	thiamine-phosphate diphosphorylase activity
IFA22_RS02040	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IFA22_RS02050	COG2022	thiamine diphosphate biosynthetic process
IFA22_RS02055	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IFA22_RS02060	COG1943	Transposase
IFA22_RS02075	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
IFA22_RS02095	COG0814	amino acid
IFA22_RS02100	COG3932	Exopolysaccharide synthesis, ExoD
IFA22_RS02115	COG1733	regulation of RNA biosynthetic process
IFA22_RS02155	COG1494	fructose-1,6-bisphosphatase
IFA22_RS02170	COG2959	enzyme of heme biosynthesis
IFA22_RS02180	COG0181	hydroxymethylbilane synthase activity
IFA22_RS02185	COG3072	Adenylate cyclase
IFA22_RS02190	COG0400	carboxylic ester hydrolase activity
IFA22_RS02195	COG1965	Belongs to the frataxin family
IFA22_RS02205	COG0019	diaminopimelate decarboxylase activity
IFA22_RS02210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IFA22_RS02225	COG1011	Hydrolase
IFA22_RS02245	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IFA22_RS02250	COG0561	phosphatase activity
IFA22_RS02265	COG1129	ABC transporter
IFA22_RS02265	COG0842	Transport permease protein
IFA22_RS02275	COG1058	Belongs to the CinA family
IFA22_RS02275	COG1546	Belongs to the CinA family
IFA22_RS02280	COG1418	mRNA catabolic process
IFA22_RS02285	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IFA22_RS02295	COG1522	sequence-specific DNA binding
IFA22_RS02300	COG1368	sulfuric ester hydrolase activity
IFA22_RS02320	COG1285	pathogenesis
IFA22_RS02340	COG4221	oxidoreductase activity
IFA22_RS02360	COG1979	alcohol dehydrogenase
IFA22_RS02370	COG2873	o-acetylhomoserine
IFA22_RS02380	COG4533	DNA binding
IFA22_RS02395	COG5380	lipid catabolic process
IFA22_RS02400	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IFA22_RS02410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IFA22_RS02415	COG2949	membrane
IFA22_RS02420	COG3291	Pkd domain containing protein
IFA22_RS02435	COG3539	Fimbrial protein
IFA22_RS02445	COG3188	usher protein
IFA22_RS02450	COG3121	Chaperone
IFA22_RS02455	COG3539	Fimbrial protein
IFA22_RS02475	COG1441	menaquinone biosynthetic process
IFA22_RS02480	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IFA22_RS02485	COG0596	Alpha beta hydrolase
IFA22_RS02490	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IFA22_RS02495	COG1169	isochorismate synthase
IFA22_RS02500	COG1575	Belongs to the MenA family. Type 1 subfamily
IFA22_RS02525	COG0513	Belongs to the DEAD box helicase family
IFA22_RS02530	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IFA22_RS02535	COG1988	membrane-bound metal-dependent
IFA22_RS02550	COG1671	Belongs to the UPF0178 family
IFA22_RS02575	COG3263	regulation of cellular component size
IFA22_RS02580	COG3722	fumarate hydratase activity
IFA22_RS02585	COG0246	Mannitol dehydrogenase
IFA22_RS02590	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IFA22_RS02590	COG2213	PTS system mannitol-specific
IFA22_RS02600	COG1309	transcriptional regulator
IFA22_RS02605	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
IFA22_RS02615	COG3916	Acyl-homoserine-lactone synthase
IFA22_RS02620	COG2771	luxR family
IFA22_RS02635	COG3133	Outer membrane lipoprotein
IFA22_RS02640	COG0456	acetyltransferase
IFA22_RS02660	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IFA22_RS02665	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IFA22_RS02675	COG3031	protein transport across the cell outer membrane
IFA22_RS02685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IFA22_RS02690	COG1459	type II secretion system
IFA22_RS02695	COG2165	general secretion pathway protein
IFA22_RS02710	COG2165	general secretion pathway protein
IFA22_RS02715	COG4795	General secretion pathway protein
IFA22_RS02725	COG3156	type II secretion system protein K
IFA22_RS02735	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
IFA22_RS02750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IFA22_RS02755	COG1011	Hydrolase
IFA22_RS02760	COG0494	nUDIX hydrolase
IFA22_RS02765	COG1218	3'(2'),5'-bisphosphate nucleotidase
IFA22_RS02770	COG0814	amino acid
IFA22_RS02775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IFA22_RS02780	COG2207	Transcriptional regulator
IFA22_RS02780	COG3708	Transcriptional regulator
IFA22_RS02790	COG0626	cystathionine gamma-synthase activity
IFA22_RS02795	COG0527	aspartate kinase activity
IFA22_RS02795	COG0460	homoserine dehydrogenase
IFA22_RS02800	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IFA22_RS02810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IFA22_RS02815	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IFA22_RS02825	COG0137	argininosuccinate synthase activity
IFA22_RS02830	COG0165	Argininosuccinate lyase
IFA22_RS02855	COG0110	maltose O-acetyltransferase activity
IFA22_RS02860	COG3174	membrane
IFA22_RS02865	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IFA22_RS02875	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IFA22_RS02880	COG4208	sulfate ABC transporter
IFA22_RS02885	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IFA22_RS02890	COG0583	DNA-binding transcription factor activity
IFA22_RS02895	COG3397	chitin binding
IFA22_RS02900	COG0840	transmembrane signaling receptor activity
IFA22_RS02930	COG0793	Belongs to the peptidase S41A family
IFA22_RS02930	COG4946	Tricorn protease homolog
IFA22_RS02950	COG1328	CTP reductase activity
IFA22_RS02955	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IFA22_RS02970	COG1448	Aminotransferase
IFA22_RS03010	COG0513	Belongs to the DEAD box helicase family
IFA22_RS03030	COG0840	transmembrane signaling receptor activity
IFA22_RS03045	COG3112	Uncharacterised protein family (UPF0231)
IFA22_RS03050	COG3835	regulator
IFA22_RS03055	COG2610	gluconate transmembrane transporter activity
IFA22_RS03060	COG1929	Belongs to the glycerate kinase type-1 family
IFA22_RS03075	COG0583	DNA-binding transcription factor activity
IFA22_RS03080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IFA22_RS03095	COG0347	Belongs to the P(II) protein family
IFA22_RS03100	COG1840	ABC-type Fe3 transport system, periplasmic component
IFA22_RS03110	COG3842	ATPase activity
IFA22_RS03115	COG2837	iron assimilation
IFA22_RS03120	COG1438	arginine binding
IFA22_RS03125	COG1126	abc transporter atp-binding protein
IFA22_RS03130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IFA22_RS03135	COG4215	(ABC) transporter
IFA22_RS03140	COG4160	amino acid transport
IFA22_RS03145	COG0039	L-malate dehydrogenase activity
IFA22_RS03150	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IFA22_RS03155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IFA22_RS03155	COG1017	nitric oxide dioxygenase activity
IFA22_RS03165	COG4536	flavin adenine dinucleotide binding
IFA22_RS03170	COG4137	Cytochrome C assembly protein
IFA22_RS03175	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IFA22_RS03180	COG0228	four-way junction DNA binding
IFA22_RS03185	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IFA22_RS03190	COG0336	Belongs to the RNA methyltransferase TrmD family
IFA22_RS03195	COG0335	large ribosomal subunit rRNA binding
IFA22_RS03205	COG3066	DNA modification
IFA22_RS03210	COG1051	belongs to the nudix hydrolase family
IFA22_RS03220	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IFA22_RS03225	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IFA22_RS03230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IFA22_RS03240	COG0583	DNA-binding transcription factor activity
IFA22_RS03245	COG0640	Transcriptional regulator
IFA22_RS03250	COG0268	Binds directly to 16S ribosomal RNA
IFA22_RS03255	COG0728	peptidoglycan biosynthetic process
IFA22_RS03265	COG0196	riboflavin kinase activity
IFA22_RS03270	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IFA22_RS03275	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IFA22_RS03280	COG1047	Peptidyl-prolyl cis-trans
IFA22_RS03285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IFA22_RS03345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IFA22_RS03345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IFA22_RS03360	COG1854	S-ribosylhomocysteine lyase activity
IFA22_RS03365	COG3706	GGDEF domain
IFA22_RS03370	COG0557	exoribonuclease II activity
IFA22_RS03375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IFA22_RS03385	COG2153	protein acetylation
IFA22_RS03405	COG1914	H( )-stimulated, divalent metal cation uptake system
IFA22_RS03410	COG0360	Binds together with S18 to 16S ribosomal RNA
IFA22_RS03415	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IFA22_RS03420	COG0359	binds to the 23S rRNA
IFA22_RS03425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IFA22_RS03450	COG1238	metal cluster binding
IFA22_RS03455	COG0612	Peptidase, M16
IFA22_RS03460	COG2918	glutathione biosynthetic process
IFA22_RS03470	COG1022	Amp-dependent synthetase and ligase
IFA22_RS03490	COG0714	Associated with various cellular activities
IFA22_RS03500	COG5001	Diguanylate cyclase
IFA22_RS03500	COG3300	MHYT domain
IFA22_RS03535	COG1902	pentaerythritol trinitrate reductase activity
IFA22_RS03545	COG2852	Protein conserved in bacteria
IFA22_RS03555	COG2957	Belongs to the agmatine deiminase family
IFA22_RS03580	COG0513	Belongs to the DEAD box helicase family
IFA22_RS03600	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
IFA22_RS03605	COG1858	cytochrome C peroxidase
IFA22_RS03630	COG2070	2-Nitropropane dioxygenase
IFA22_RS03665	COG3318	Belongs to the UPF0149 family
IFA22_RS03665	COG3012	SEC-C Motif Domain Protein
IFA22_RS03755	COG2003	Belongs to the UPF0758 family
IFA22_RS03805	COG3311	Transcriptional regulator
IFA22_RS03815	COG2916	Histone family protein nucleoid-structuring protein H-NS
IFA22_RS03845	COG0582	viral genome integration into host DNA
IFA22_RS03850	COG2816	NAD+ diphosphatase activity
IFA22_RS03855	COG2205	protein histidine kinase activity
IFA22_RS03860	COG0745	RESPONSE REGULATOR receiver
IFA22_RS03865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IFA22_RS03870	COG1136	(ABC) transporter
IFA22_RS03870	COG0577	efflux transmembrane transporter activity
IFA22_RS03875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IFA22_RS03880	COG1126	abc transporter atp-binding protein
IFA22_RS03885	COG0765	amino acid transport
IFA22_RS03890	COG0765	amino acid transport
IFA22_RS03895	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IFA22_RS03900	COG1505	serine-type exopeptidase activity
IFA22_RS03920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IFA22_RS03935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IFA22_RS03940	COG4991	sh3 domain protein
IFA22_RS03955	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IFA22_RS03960	COG1940	carbohydrate kinase activity
IFA22_RS03965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IFA22_RS03970	COG0126	phosphoglycerate kinase activity
IFA22_RS03980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IFA22_RS04020	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IFA22_RS04030	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IFA22_RS04035	COG1595	DNA-templated transcription, initiation
IFA22_RS04055	COG0481	GTPase activity
IFA22_RS04060	COG0681	Belongs to the peptidase S26 family
IFA22_RS04065	COG0571	ribonuclease III activity
IFA22_RS04075	COG1381	Involved in DNA repair and RecF pathway recombination
IFA22_RS04080	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IFA22_RS04095	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IFA22_RS04100	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IFA22_RS04105	COG3716	PTS system mannose fructose sorbose family IID component
IFA22_RS04115	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IFA22_RS04120	COG2222	sugar isomerase
IFA22_RS04130	COG1349	DNA-binding transcription factor activity
IFA22_RS04135	COG3023	N-Acetylmuramoyl-L-alanine amidase
IFA22_RS04140	COG4807	Protein conserved in bacteria
IFA22_RS04150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IFA22_RS04155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IFA22_RS04160	COG3956	TIGRFAM MazG family protein
IFA22_RS04165	COG0504	CTP synthase activity
IFA22_RS04170	COG0148	phosphopyruvate hydratase activity
IFA22_RS04175	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IFA22_RS04180	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IFA22_RS04190	COG0585	pseudouridine synthase activity
IFA22_RS04195	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IFA22_RS04200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IFA22_RS04205	COG1238	metal cluster binding
IFA22_RS04220	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IFA22_RS04225	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IFA22_RS04230	COG1610	YqeY-like protein
IFA22_RS04235	COG0358	DNA primase activity
IFA22_RS04240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IFA22_RS04265	COG0151	Belongs to the GarS family
IFA22_RS04270	COG0138	bifunctional purine biosynthesis protein purh
IFA22_RS04280	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IFA22_RS04285	COG3036	rescue of stalled ribosome
IFA22_RS04290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IFA22_RS04295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IFA22_RS04305	COG0673	inositol 2-dehydrogenase activity
IFA22_RS04315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IFA22_RS04320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IFA22_RS04335	COG0477	Major facilitator Superfamily
IFA22_RS04345	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IFA22_RS04350	COG1027	Aspartate ammonia-lyase
IFA22_RS04355	COG3030	protein affecting phage T7 exclusion by the F plasmid
IFA22_RS04360	COG0534	Mate efflux family protein
IFA22_RS04365	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IFA22_RS04370	COG0459	protein refolding
IFA22_RS04380	COG5001	Diguanylate cyclase
IFA22_RS04380	COG3300	MHYT domain
IFA22_RS04390	COG0564	pseudouridine synthase activity
IFA22_RS04395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IFA22_RS04435	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IFA22_RS04440	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
IFA22_RS04445	COG1178	ABC-type Fe3 transport system permease component
IFA22_RS04450	COG4143	(ABC) transporter
IFA22_RS04465	COG0066	3-isopropylmalate dehydratase activity
IFA22_RS04470	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IFA22_RS04475	COG0473	3-isopropylmalate dehydrogenase activity
IFA22_RS04480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IFA22_RS04490	COG0671	phosphoesterase, PA-phosphatase related
IFA22_RS04495	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IFA22_RS04505	COG0028	Belongs to the TPP enzyme family
IFA22_RS04515	COG0857	belongs to the CobB CobQ family
IFA22_RS04515	COG0280	phosphate acetyltransferase
IFA22_RS04520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IFA22_RS04530	COG3013	Belongs to the UPF0304 family
IFA22_RS04535	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IFA22_RS04540	COG2716	regulation of RNA biosynthetic process
IFA22_RS04550	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IFA22_RS04555	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IFA22_RS04570	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IFA22_RS04590	COG2198	Histidine kinase
IFA22_RS04590	COG5002	protein histidine kinase activity
IFA22_RS04590	COG0784	Response regulator, receiver
IFA22_RS04615	COG0840	transmembrane signaling receptor activity
IFA22_RS04625	COG1464	Belongs to the NlpA lipoprotein family
IFA22_RS04630	COG2011	ABC-type metal ion transport system permease component
IFA22_RS04635	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IFA22_RS04655	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IFA22_RS04660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IFA22_RS04660	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IFA22_RS04665	COG0802	atpase or kinase
IFA22_RS04680	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IFA22_RS04685	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IFA22_RS04690	COG1923	regulation of RNA biosynthetic process
IFA22_RS04695	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IFA22_RS04700	COG0330	HflC and HflK could
IFA22_RS04705	COG0330	HflC and HflK could
IFA22_RS04710	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
IFA22_RS04715	COG0142	geranyltranstransferase activity
IFA22_RS04720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IFA22_RS04725	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IFA22_RS04730	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IFA22_RS04785	COG0848	biopolymer transport protein
IFA22_RS04790	COG0811	peptide transport
IFA22_RS04795	COG0811	peptide transport
IFA22_RS04805	COG4206	TonB-dependent receptor
IFA22_RS04810	COG4174	ABC transporter (Permease)
IFA22_RS04815	COG4239	(ABC) transporter, permease
IFA22_RS04830	COG4608	Belongs to the ABC transporter superfamily
IFA22_RS04835	COG2195	Cleaves the N-terminal amino acid of tripeptides
IFA22_RS04840	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IFA22_RS04845	COG1073	alpha beta
IFA22_RS04860	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IFA22_RS04885	COG0243	molybdopterin cofactor binding
IFA22_RS04900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IFA22_RS04900	COG1116	anion transmembrane transporter activity
IFA22_RS04905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IFA22_RS04910	COG1116	anion transmembrane transporter activity
IFA22_RS04915	COG2146	nitrite reductase [NAD(P)H] activity
IFA22_RS04915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IFA22_RS04920	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IFA22_RS04920	COG2146	nitrite reductase [NAD(P)H] activity
IFA22_RS04925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IFA22_RS04930	COG2313	pseudouridylate synthase activity
IFA22_RS04935	COG3338	carbonate dehydratase activity
IFA22_RS04940	COG1858	cytochrome C peroxidase
IFA22_RS04975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IFA22_RS04980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IFA22_RS05005	COG2986	histidine ammonia-lyase
IFA22_RS05030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IFA22_RS05040	COG1028	Short-chain dehydrogenase reductase Sdr
IFA22_RS05055	COG0521	Mo-molybdopterin cofactor biosynthetic process
IFA22_RS05065	COG2966	Psort location CytoplasmicMembrane, score
IFA22_RS05070	COG3610	response to peptide
IFA22_RS05080	COG4175	Glycine betaine
IFA22_RS05085	COG4176	ABC-type proline glycine betaine transport system permease component
IFA22_RS05090	COG2113	Glycine betaine
IFA22_RS05095	COG0175	sulfate reduction
IFA22_RS05100	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IFA22_RS05105	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IFA22_RS05110	COG0384	phenazine biosynthesis protein PhzF
IFA22_RS05115	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IFA22_RS05130	COG0786	glutamate:sodium symporter activity
IFA22_RS05135	COG0252	asparaginase activity
IFA22_RS05140	COG3139	Protein of unknown function (DUF1315)
IFA22_RS05160	COG0616	signal peptide processing
IFA22_RS05165	COG1902	pentaerythritol trinitrate reductase activity
IFA22_RS05165	COG0446	pyridine nucleotide-disulphide oxidoreductase
IFA22_RS05170	COG0778	Nitroreductase
IFA22_RS05185	COG2264	protein methyltransferase activity
IFA22_RS05190	COG0604	alcohol dehydrogenase
IFA22_RS05195	COG0583	DNA-binding transcription factor activity
IFA22_RS05200	COG1263	PTS System
IFA22_RS05200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IFA22_RS05200	COG2190	(PTS) system
IFA22_RS05205	COG4145	pantothenate transmembrane transporter activity
IFA22_RS05215	COG0439	Biotin carboxylase
IFA22_RS05220	COG0511	ligase activity, forming carbon-carbon bonds
IFA22_RS05225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IFA22_RS05230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IFA22_RS05240	COG5001	Diguanylate cyclase
IFA22_RS05240	COG3300	MHYT domain
IFA22_RS05260	COG3381	protein complex oligomerization
IFA22_RS05275	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IFA22_RS05290	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IFA22_RS05295	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IFA22_RS05295	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IFA22_RS05315	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IFA22_RS05320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IFA22_RS05325	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IFA22_RS05330	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IFA22_RS05335	COG4172	Belongs to the ABC transporter superfamily
IFA22_RS05345	COG0601	transmembrane transport
IFA22_RS05355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IFA22_RS05360	COG0142	geranyltranstransferase activity
IFA22_RS05365	COG1722	exodeoxyribonuclease VII activity
IFA22_RS05370	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IFA22_RS05375	COG1360	Flagellar Motor Protein
IFA22_RS05390	COG1534	Rna-binding protein
IFA22_RS05395	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IFA22_RS05405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IFA22_RS05410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IFA22_RS05415	COG0149	triose-phosphate isomerase activity
IFA22_RS05420	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IFA22_RS05435	COG0779	Required for maturation of 30S ribosomal subunits
IFA22_RS05440	COG0195	Participates in both transcription termination and antitermination
IFA22_RS05445	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IFA22_RS05450	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IFA22_RS05455	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IFA22_RS05460	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IFA22_RS05465	COG1185	polyribonucleotide nucleotidyltransferase activity
IFA22_RS05470	COG2211	Major facilitator Superfamily
IFA22_RS05475	COG3706	GGDEF domain
IFA22_RS05480	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IFA22_RS05490	COG0114	fumarate hydratase activity
IFA22_RS05500	COG1966	Carbon starvation protein
IFA22_RS05505	COG3279	Response regulator of the LytR AlgR family
IFA22_RS05510	COG3275	phosphorelay sensor kinase activity
IFA22_RS05575	COG0312	modulator of DNA gyrase
IFA22_RS05580	COG0312	modulator of DNA gyrase
IFA22_RS05590	COG4974	Belongs to the 'phage' integrase family
IFA22_RS05595	COG1970	mechanosensitive ion channel activity
IFA22_RS05600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IFA22_RS05610	COG0789	Transcriptional regulator
IFA22_RS05625	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IFA22_RS05630	COG3545	Serine hydrolase
IFA22_RS05640	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IFA22_RS05645	COG0321	lipoyl(octanoyl) transferase activity
IFA22_RS05650	COG2921	Belongs to the UPF0250 family
IFA22_RS05655	COG1686	Belongs to the peptidase S11 family
IFA22_RS05660	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IFA22_RS05665	COG2951	lytic endotransglycosylase activity
IFA22_RS05670	COG0772	Belongs to the SEDS family
IFA22_RS05675	COG0772	Belongs to the SEDS family
IFA22_RS05680	COG0768	penicillin binding
IFA22_RS05685	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IFA22_RS05690	COG0799	negative regulation of ribosome biogenesis
IFA22_RS05695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IFA22_RS05715	COG0495	leucyl-tRNA aminoacylation
IFA22_RS05720	COG2888	peptidyl-tyrosine sulfation
IFA22_RS05725	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IFA22_RS05730	COG4535	Mg2 and Co2 transporter CorC
IFA22_RS05735	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IFA22_RS05740	COG1702	phosphate starvation-inducible protein PhoH
IFA22_RS05745	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IFA22_RS05750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IFA22_RS05755	COG1335	isochorismatase
IFA22_RS05765	COG3706	GGDEF domain
IFA22_RS05780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IFA22_RS05800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IFA22_RS05810	COG3647	Membrane
IFA22_RS05815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IFA22_RS05825	COG0516	GMP reductase activity
IFA22_RS05835	COG0642	Histidine kinase
IFA22_RS05875	COG3214	Protein conserved in bacteria
IFA22_RS05900	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
IFA22_RS05905	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IFA22_RS05910	COG1053	succinate dehydrogenase
IFA22_RS05920	COG0584	glycerophosphoryl diester phosphodiesterase
IFA22_RS05925	COG1511	domain protein
IFA22_RS05925	COG3264	Mechanosensitive ion channel
IFA22_RS05935	COG0739	heme binding
IFA22_RS05950	COG0583	DNA-binding transcription factor activity
IFA22_RS05975	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IFA22_RS06005	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IFA22_RS06010	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IFA22_RS06020	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IFA22_RS06030	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IFA22_RS06040	COG0180	Tryptophanyl-tRNA synthetase
IFA22_RS06055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IFA22_RS06065	COG1012	belongs to the aldehyde dehydrogenase family
IFA22_RS06075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IFA22_RS06085	COG0674	pyruvate-flavodoxin oxidoreductase activity
IFA22_RS06085	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IFA22_RS06085	COG1013	pyruvate-flavodoxin oxidoreductase activity
IFA22_RS06085	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IFA22_RS06095	COG0366	Alpha amylase catalytic
IFA22_RS06125	COG0490	domain, Protein
IFA22_RS06125	COG0471	metal ion transport
IFA22_RS06170	COG0012	GTP binding
IFA22_RS06175	COG0193	aminoacyl-tRNA hydrolase activity
IFA22_RS06180	COG0737	Belongs to the 5'-nucleotidase family
IFA22_RS06185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IFA22_RS06195	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IFA22_RS06200	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IFA22_RS06205	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IFA22_RS06210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IFA22_RS06215	COG2890	protein-(glutamine-N5) methyltransferase activity
IFA22_RS06225	COG2912	Transglutaminase-like superfamily
IFA22_RS06230	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IFA22_RS06235	COG1301	dicarboxylic acid transport
IFA22_RS06245	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IFA22_RS06260	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IFA22_RS06265	COG1115	amino acid carrier protein
IFA22_RS06280	COG0714	Associated with various cellular activities
IFA22_RS06290	COG3104	oligopeptide transport
IFA22_RS06295	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IFA22_RS06300	COG1678	Uncharacterized ACR, COG1678
IFA22_RS06310	COG0189	ligase activity
IFA22_RS06315	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IFA22_RS06325	COG3091	SprT-like family
IFA22_RS06335	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IFA22_RS06355	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IFA22_RS06360	COG0739	heme binding
IFA22_RS06365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IFA22_RS06370	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
IFA22_RS06370	COG3408	Glycogen debranching enzyme
IFA22_RS06380	COG1881	PFAM PEBP family protein
IFA22_RS06385	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IFA22_RS06390	COG0583	DNA-binding transcription factor activity
IFA22_RS06400	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IFA22_RS06410	COG0583	DNA-binding transcription factor activity
IFA22_RS06415	COG1028	Short-chain dehydrogenase reductase Sdr
IFA22_RS06420	COG0616	signal peptide processing
IFA22_RS06425	COG3724	N-succinylarginine dihydrolase activity
IFA22_RS06445	COG0840	transmembrane signaling receptor activity
IFA22_RS06455	COG2971	BadF BadG BcrA BcrD
IFA22_RS06465	COG4608	Belongs to the ABC transporter superfamily
IFA22_RS06470	COG0444	Belongs to the ABC transporter superfamily
IFA22_RS06475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IFA22_RS06480	COG0601	transmembrane transport
IFA22_RS06485	COG4166	transmembrane transport
IFA22_RS06520	COG3220	belongs to the UPF0276 family
IFA22_RS06550	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IFA22_RS06555	COG1289	transmembrane transporter activity
IFA22_RS06560	COG0303	'Molybdopterin
IFA22_RS06565	COG0746	molybdenum cofactor guanylyltransferase activity
IFA22_RS06575	COG4662	Binding-protein-dependent transport system inner membrane component
IFA22_RS06585	COG2204	response regulator
IFA22_RS06590	COG3852	Histidine kinase
IFA22_RS06595	COG1910	domain protein
IFA22_RS06600	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IFA22_RS06635	COG3383	formate dehydrogenase (NAD+) activity
IFA22_RS06635	COG3383	formate dehydrogenase (NAD+) activity
IFA22_RS06640	COG0437	4 iron, 4 sulfur cluster binding
IFA22_RS06655	COG0281	malic enzyme
IFA22_RS06685	COG1196	nuclear chromosome segregation
IFA22_RS06685	COG3264	Mechanosensitive ion channel
IFA22_RS06690	COG0469	pyruvate kinase activity
IFA22_RS06705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IFA22_RS06705	COG4651	solute:proton antiporter activity
IFA22_RS06715	COG2974	May be involved in recombination
IFA22_RS06725	COG0420	3'-5' exonuclease activity
IFA22_RS06730	COG0419	ATPase involved in DNA repair
IFA22_RS06740	COG3038	cytochrome b561
IFA22_RS06755	COG2190	(PTS) system
IFA22_RS06765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IFA22_RS06770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IFA22_RS06775	COG0542	response to heat
IFA22_RS06790	COG1720	tRNA m6t6A37 methyltransferase activity
IFA22_RS06810	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IFA22_RS06815	COG4988	ABC transporter
IFA22_RS06830	COG0745	RESPONSE REGULATOR receiver
IFA22_RS06840	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IFA22_RS06855	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
IFA22_RS06860	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IFA22_RS06870	COG0083	homoserine kinase activity
IFA22_RS06875	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IFA22_RS06880	COG4319	ketosteroid isomerase
IFA22_RS06920	COG0813	purine-nucleoside phosphorylase activity
IFA22_RS06935	COG2205	protein histidine kinase activity
IFA22_RS06935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IFA22_RS06940	COG3384	dioxygenase
IFA22_RS06950	COG1283	sodium-dependent phosphate transmembrane transporter activity
IFA22_RS06960	COG0531	amino acid
IFA22_RS06970	COG0531	amino acid
IFA22_RS06985	COG1396	sequence-specific DNA binding
IFA22_RS06985	COG1917	Cupin 2, conserved barrel domain protein
IFA22_RS06990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IFA22_RS07010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IFA22_RS07015	COG2375	cellular response to nickel ion
IFA22_RS07025	COG0577	efflux transmembrane transporter activity
IFA22_RS07025	COG1136	(ABC) transporter
IFA22_RS07030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IFA22_RS07040	COG1227	inorganic diphosphatase activity
IFA22_RS07045	COG0497	DNA recombination
IFA22_RS07050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IFA22_RS07055	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IFA22_RS07060	COG0443	Heat shock 70 kDa protein
IFA22_RS07065	COG0484	heat shock protein binding
IFA22_RS07095	COG1285	pathogenesis
IFA22_RS07110	COG0640	Transcriptional regulator
IFA22_RS07145	COG0095	Lipoate-protein ligase
IFA22_RS07165	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IFA22_RS07170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IFA22_RS07190	COG0708	Exodeoxyribonuclease III
IFA22_RS07205	COG2211	Major facilitator Superfamily
IFA22_RS07250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IFA22_RS07255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IFA22_RS07260	COG1845	cytochrome c oxidase, subunit III
IFA22_RS07265	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IFA22_RS07270	COG0109	protoheme IX farnesyltransferase activity
IFA22_RS07275	COG2814	Major facilitator Superfamily
IFA22_RS07285	COG0784	Response regulator, receiver
IFA22_RS07285	COG2205	protein histidine kinase activity
IFA22_RS07285	COG2198	Histidine kinase
IFA22_RS07290	COG1879	ABC-type sugar transport system periplasmic component
IFA22_RS07300	COG0745	RESPONSE REGULATOR receiver
IFA22_RS07305	COG3005	denitrification pathway
IFA22_RS07355	COG2003	Belongs to the UPF0758 family
IFA22_RS07390	COG0583	DNA-binding transcription factor activity
IFA22_RS07405	COG0549	Belongs to the carbamate kinase family
IFA22_RS07410	COG1304	FMN binding
IFA22_RS07415	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IFA22_RS07420	COG1335	isochorismatase
IFA22_RS07435	COG3311	Transcriptional regulator
IFA22_RS07455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IFA22_RS07475	COG1988	membrane-bound metal-dependent
IFA22_RS07505	COG0159	tryptophan synthase activity
IFA22_RS07510	COG0133	tryptophan synthase activity
IFA22_RS07515	COG0135	phosphoribosylanthranilate isomerase activity
IFA22_RS07515	COG0134	indole-3-glycerol-phosphate synthase activity
IFA22_RS07520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IFA22_RS07525	COG0512	Glutamine amidotransferase of anthranilate synthase
IFA22_RS07525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IFA22_RS07530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IFA22_RS07540	COG0009	L-threonylcarbamoyladenylate synthase
IFA22_RS07550	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IFA22_RS07560	COG1946	Acyl-CoA thioesterase
IFA22_RS07575	COG1309	transcriptional regulator
IFA22_RS07580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IFA22_RS07585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IFA22_RS07635	COG1484	DNA-dependent DNA replication
IFA22_RS07640	COG4584	PFAM Integrase catalytic
IFA22_RS07670	COG2003	Belongs to the UPF0758 family
IFA22_RS07695	COG1091	dTDP-4-dehydrorhamnose reductase activity
IFA22_RS07735	COG1215	transferase activity, transferring glycosyl groups
IFA22_RS07760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IFA22_RS07765	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
IFA22_RS07800	COG4372	Transposase
IFA22_RS07810	COG3132	Protein of unknown function, DUF480
IFA22_RS07850	COG1278	Cold shock
IFA22_RS07880	COG0697	spore germination
IFA22_RS07885	COG1349	DNA-binding transcription factor activity
IFA22_RS07890	COG1882	Formate acetyltransferase
IFA22_RS07895	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IFA22_RS07900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IFA22_RS07930	COG0622	Phosphoesterase
IFA22_RS07945	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
IFA22_RS07950	COG0835	chemotaxis
IFA22_RS07950	COG0784	Response regulator, receiver
IFA22_RS07955	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IFA22_RS07960	COG1815	bacterial-type flagellum-dependent cell motility
IFA22_RS07980	COG4787	bacterial-type flagellum-dependent cell motility
IFA22_RS07990	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IFA22_RS07995	COG1706	bacterial-type flagellum-dependent cell motility
IFA22_RS08000	COG3951	Flagellar rod assembly protein muramidase FlgJ
IFA22_RS08000	COG1705	Flagellar rod assembly protein muramidase FlgJ
IFA22_RS08005	COG1256	bacterial-type flagellum assembly
IFA22_RS08015	COG2239	Acts as a magnesium transporter
IFA22_RS08025	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IFA22_RS08030	COG2716	regulation of RNA biosynthetic process
IFA22_RS08055	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IFA22_RS08060	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IFA22_RS08065	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IFA22_RS08070	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IFA22_RS08090	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IFA22_RS08105	COG0590	tRNA wobble adenosine to inosine editing
IFA22_RS08110	COG0573	inorganic phosphate transmembrane transporter activity
IFA22_RS08115	COG0581	inorganic phosphate transmembrane transporter activity
IFA22_RS08120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IFA22_RS08125	COG0704	Plays a role in the regulation of phosphate uptake
IFA22_RS08130	COG1253	flavin adenine dinucleotide binding
IFA22_RS08145	COG0531	amino acid
IFA22_RS08165	COG1126	abc transporter atp-binding protein
IFA22_RS08170	COG0765	amino acid transport
IFA22_RS08175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IFA22_RS08180	COG3706	GGDEF domain
IFA22_RS08185	COG2271	Major facilitator Superfamily
IFA22_RS08200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IFA22_RS08225	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IFA22_RS08230	COG0477	Major facilitator Superfamily
IFA22_RS08235	COG0123	including yeast histone deacetylase and acetoin utilization protein
IFA22_RS08245	COG1199	ATP-dependent helicase activity
IFA22_RS08265	COG1448	Aminotransferase
IFA22_RS08270	COG0433	COG0433 Predicted ATPase
IFA22_RS08285	COG0658	competence protein
IFA22_RS08285	COG2333	competence protein COMEC
IFA22_RS08295	COG1663	tetraacyldisaccharide 4'-kinase activity
IFA22_RS08300	COG2835	tetraacyldisaccharide 4'-kinase activity
IFA22_RS08305	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IFA22_RS08310	COG2197	response regulator
IFA22_RS08315	COG0322	excinuclease ABC activity
IFA22_RS08435	COG3385	transposase activity
IFA22_RS08445	COG2314	TM2 domain
IFA22_RS08535	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
IFA22_RS08540	COG0437	4 iron, 4 sulfur cluster binding
IFA22_RS08545	COG3301	Polysulphide reductase, NrfD
IFA22_RS08550	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IFA22_RS08560	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IFA22_RS08590	COG2199	diguanylate cyclase activity
IFA22_RS08590	COG2203	Gaf domain
IFA22_RS08620	COG2119	membrane
IFA22_RS08625	COG0023	Translation Initiation Factor
IFA22_RS08650	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IFA22_RS08665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IFA22_RS08665	COG2205	protein histidine kinase activity
IFA22_RS08675	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
IFA22_RS08685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IFA22_RS08690	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IFA22_RS08695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IFA22_RS08700	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IFA22_RS08705	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IFA22_RS08715	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IFA22_RS08720	COG0505	Belongs to the CarA family
IFA22_RS08725	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IFA22_RS08730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IFA22_RS08765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IFA22_RS08770	COG0513	Belongs to the DEAD box helicase family
IFA22_RS08780	COG4104	PAAR repeat-containing protein
IFA22_RS08810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IFA22_RS08815	COG0765	amino acid transport
IFA22_RS08820	COG1126	abc transporter atp-binding protein
IFA22_RS08825	COG0493	'glutamate synthase
IFA22_RS08830	COG0070	glutamate synthase
IFA22_RS08830	COG0067	glutamate synthase
IFA22_RS08830	COG0069	glutamate synthase activity
IFA22_RS08835	COG1242	4 iron, 4 sulfur cluster binding
IFA22_RS08905	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IFA22_RS08910	COG0574	Belongs to the PEP-utilizing enzyme family
IFA22_RS08910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IFA22_RS08940	COG1464	Belongs to the NlpA lipoprotein family
IFA22_RS08945	COG0671	phosphoesterase, PA-phosphatase related
IFA22_RS08950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IFA22_RS08955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IFA22_RS08965	COG0101	tRNA pseudouridine synthase activity
IFA22_RS08970	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IFA22_RS08975	COG0285	dihydrofolate synthase activity
IFA22_RS08980	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IFA22_RS08985	COG2920	part of a sulfur-relay system
IFA22_RS08990	COG1289	transmembrane transporter activity
IFA22_RS08995	COG0670	Belongs to the BI1 family
IFA22_RS09015	COG2194	sulfuric ester hydrolase activity
IFA22_RS09025	COG0392	lysyltransferase activity
IFA22_RS09025	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IFA22_RS09035	COG0840	transmembrane signaling receptor activity
IFA22_RS09040	COG2199	diguanylate cyclase activity
IFA22_RS09040	COG2203	Gaf domain
IFA22_RS09045	COG0564	pseudouridine synthase activity
IFA22_RS09060	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IFA22_RS09070	COG0625	glutathione transferase activity
IFA22_RS09075	COG0625	glutathione transferase activity
IFA22_RS09085	COG0367	asparagine synthase
IFA22_RS09095	COG4651	solute:proton antiporter activity
IFA22_RS09095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IFA22_RS09100	COG0647	UMP catabolic process
IFA22_RS09110	COG1902	pentaerythritol trinitrate reductase activity
IFA22_RS09115	COG1253	flavin adenine dinucleotide binding
IFA22_RS09125	COG0277	FAD linked oxidase domain protein
IFA22_RS09125	COG0247	lactate metabolic process
IFA22_RS09135	COG2050	protein possibly involved in aromatic compounds catabolism
IFA22_RS09145	COG2056	Na+-H+ antiporter family
IFA22_RS09150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IFA22_RS09165	COG0346	lactoylglutathione lyase activity
IFA22_RS09170	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IFA22_RS09175	COG4660	Part of a membrane complex involved in electron transport
IFA22_RS09180	COG4659	FMN binding
IFA22_RS09185	COG4658	electron transport chain
IFA22_RS09195	COG2878	Part of a membrane complex involved in electron transport
IFA22_RS09200	COG4657	Part of a membrane complex involved in electron transport
IFA22_RS09205	COG0697	spore germination
IFA22_RS09220	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IFA22_RS09225	COG1288	antiporter activity
IFA22_RS09230	COG0436	Aminotransferase
IFA22_RS09240	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IFA22_RS09245	COG2027	D-alanyl-D-alanine carboxypeptidase
IFA22_RS09250	COG1061	Type III restriction enzyme res subunit
IFA22_RS09255	COG1566	PFAM secretion protein HlyD family protein
IFA22_RS09265	COG1966	Carbon starvation protein
IFA22_RS09270	COG3279	Response regulator of the LytR AlgR family
IFA22_RS09275	COG3275	phosphorelay sensor kinase activity
IFA22_RS09280	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IFA22_RS09280	COG2199	diguanylate cyclase activity
IFA22_RS09285	COG1454	alcohol dehydrogenase
IFA22_RS09285	COG1012	belongs to the aldehyde dehydrogenase family
IFA22_RS09295	COG2095	MarC family integral membrane protein
IFA22_RS09305	COG0601	transmembrane transport
IFA22_RS09310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IFA22_RS09325	COG0861	Integral membrane protein TerC family
IFA22_RS09330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IFA22_RS09340	COG1301	dicarboxylic acid transport
IFA22_RS09355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IFA22_RS09370	COG0537	adenosine 5'-monophosphoramidase activity
IFA22_RS09405	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IFA22_RS09410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IFA22_RS09425	COG2354	Protein conserved in bacteria
IFA22_RS09440	COG2233	PERMEase
IFA22_RS09445	COG3150	esterase
IFA22_RS09450	COG1252	NADH dehydrogenase
IFA22_RS09470	COG0393	Putative heavy-metal-binding
IFA22_RS09480	COG1648	precorrin-2 dehydrogenase activity
IFA22_RS09480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IFA22_RS09500	COG4667	esterase of the alpha-beta hydrolase superfamily
IFA22_RS09505	COG1619	proteins homologs of microcin C7 resistance protein MccF
IFA22_RS09510	COG1368	sulfuric ester hydrolase activity
IFA22_RS09520	COG0527	aspartate kinase activity
IFA22_RS09525	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IFA22_RS09525	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IFA22_RS09530	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IFA22_RS09550	COG0596	Alpha beta hydrolase
IFA22_RS09555	COG0346	lactoylglutathione lyase activity
IFA22_RS09565	COG0583	DNA-binding transcription factor activity
IFA22_RS09570	COG1620	l-lactate permease
IFA22_RS09580	COG1139	Iron-sulfur cluster binding protein
IFA22_RS09630	COG0577	efflux transmembrane transporter activity
IFA22_RS09635	COG1136	(ABC) transporter
IFA22_RS09645	COG2814	Major facilitator Superfamily
IFA22_RS09660	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
IFA22_RS09665	COG0672	)-iron permease
IFA22_RS09695	COG0659	secondary active sulfate transmembrane transporter activity
IFA22_RS09715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IFA22_RS09720	COG0840	transmembrane signaling receptor activity
IFA22_RS09730	COG2201	protein-glutamate methylesterase activity
IFA22_RS09740	COG0835	chemotaxis
IFA22_RS09745	COG0840	transmembrane signaling receptor activity
IFA22_RS09760	COG0745	RESPONSE REGULATOR receiver
IFA22_RS09765	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
IFA22_RS09770	COG0437	4 iron, 4 sulfur cluster binding
IFA22_RS09775	COG5557	Pfam Polysulphide reductase, NrfD
IFA22_RS09780	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
IFA22_RS09785	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IFA22_RS09790	COG1773	rubredoxin
IFA22_RS09805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IFA22_RS09810	COG0444	Belongs to the ABC transporter superfamily
IFA22_RS09815	COG3842	ATPase activity
IFA22_RS09820	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IFA22_RS09825	COG0375	protein maturation
IFA22_RS09830	COG0309	Hydrogenase expression formation protein (HypE)
IFA22_RS09840	COG0298	carbon dioxide binding
IFA22_RS09845	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IFA22_RS09860	COG1921	L-seryl-tRNASec selenium transferase activity
IFA22_RS09875	COG5433	transposase activity
IFA22_RS09890	COG3260	NADH ubiquinone oxidoreductase 20
IFA22_RS09895	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IFA22_RS09900	COG3261	NADH dehydrogenase
IFA22_RS09900	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
IFA22_RS09905	COG0650	Formate hydrogenlyase subunit 4
IFA22_RS09910	COG0651	ATP synthesis coupled electron transport
IFA22_RS09915	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IFA22_RS09920	COG3158	transport of potassium into the cell
IFA22_RS09930	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IFA22_RS09940	COG3385	transposase activity
IFA22_RS09960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IFA22_RS09965	COG0326	Molecular chaperone. Has ATPase activity
IFA22_RS09970	COG0563	adenylate kinase activity
IFA22_RS09975	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IFA22_RS09985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IFA22_RS10000	COG5001	Diguanylate cyclase
IFA22_RS10000	COG3300	MHYT domain
IFA22_RS10005	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IFA22_RS10025	COG1021	2,3-dihydroxybenzoate-AMP ligase
IFA22_RS10030	COG1535	isochorismatase
IFA22_RS10030	COG3433	isochorismatase activity
IFA22_RS10035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IFA22_RS10040	COG1028	Short-chain dehydrogenase reductase Sdr
IFA22_RS10050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IFA22_RS10060	COG1051	belongs to the nudix hydrolase family
IFA22_RS10065	COG3088	subunit of a heme lyase
IFA22_RS10065	COG4235	cytochrome complex assembly
IFA22_RS10070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IFA22_RS10075	COG1138	Cytochrome C-type biogenesis protein
IFA22_RS10080	COG3301	Polysulphide reductase, NrfD
IFA22_RS10085	COG0437	4 iron, 4 sulfur cluster binding
IFA22_RS10090	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
IFA22_RS10100	COG0247	lactate metabolic process
IFA22_RS10105	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
IFA22_RS10110	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IFA22_RS10115	COG3012	SEC-C Motif Domain Protein
IFA22_RS10120	COG0840	transmembrane signaling receptor activity
IFA22_RS10125	COG1940	carbohydrate kinase activity
IFA22_RS10125	COG1846	Transcriptional regulator
IFA22_RS10130	COG3290	protein histidine kinase activity
IFA22_RS10135	COG4565	transcriptional regulatory protein
IFA22_RS10155	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IFA22_RS10160	COG0569	domain protein
IFA22_RS10160	COG2985	domain, Protein
IFA22_RS10170	COG0556	nucleotide-excision repair
IFA22_RS10180	COG0586	Pfam SNARE associated Golgi protein
IFA22_RS10185	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IFA22_RS10190	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IFA22_RS10195	COG2186	Transcriptional regulator
IFA22_RS10200	COG2719	SpoVR family
IFA22_RS10210	COG2766	serine protein kinase
IFA22_RS10215	COG0514	ATP-dependent DNA helicase (RecQ)
IFA22_RS10220	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IFA22_RS10225	COG0814	amino acid
IFA22_RS10235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IFA22_RS10255	COG0058	SHG alpha-glucan phosphorylase activity
IFA22_RS10260	COG0471	metal ion transport
IFA22_RS10265	COG3118	belongs to the thioredoxin family
IFA22_RS10275	COG1132	(ABC) transporter
IFA22_RS10280	COG1132	(ABC) transporter
IFA22_RS10290	COG2501	S4 domain
IFA22_RS10300	COG3243	poly(R)-hydroxyalkanoic acid synthase
IFA22_RS10320	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IFA22_RS10325	COG2329	Antibiotic biosynthesis monooxygenase
IFA22_RS10360	COG1742	UPF0060 membrane protein
IFA22_RS10370	COG0456	acetyltransferase
IFA22_RS10375	COG0513	Belongs to the DEAD box helicase family
IFA22_RS10380	COG0386	Belongs to the glutathione peroxidase family
IFA22_RS10390	COG1181	Belongs to the D-alanine--D-alanine ligase family
IFA22_RS10400	COG3148	PFAM DTW domain containing protein
IFA22_RS10405	COG0730	response to heat
IFA22_RS10410	COG0583	DNA-binding transcription factor activity
IFA22_RS10425	COG3593	DNA synthesis involved in DNA repair
IFA22_RS10480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IFA22_RS10485	COG1011	Hydrolase
IFA22_RS10490	COG1473	amidohydrolase
IFA22_RS10495	COG0205	6-phosphofructokinase activity
IFA22_RS10505	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IFA22_RS10510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IFA22_RS10520	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IFA22_RS10525	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IFA22_RS10530	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IFA22_RS10540	COG0242	peptide deformylase activity
IFA22_RS10570	COG0384	phenazine biosynthesis protein PhzF
IFA22_RS10585	COG2824	Alkylphosphonate utilization operon protein PhnA
IFA22_RS10610	COG0588	phosphoglycerate mutase activity
IFA22_RS10615	COG3706	GGDEF domain
IFA22_RS10625	COG2840	Smr protein MutS2
IFA22_RS10630	COG2890	protein-(glutamine-N5) methyltransferase activity
IFA22_RS10635	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IFA22_RS10645	COG0513	Belongs to the DEAD box helicase family
IFA22_RS10650	COG5654	RES domain protein
IFA22_RS10660	COG0814	amino acid
IFA22_RS10665	COG1609	Transcriptional regulator
IFA22_RS10670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IFA22_RS10670	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IFA22_RS10675	COG1105	Belongs to the carbohydrate kinase PfkB family
IFA22_RS10680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IFA22_RS10680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IFA22_RS10680	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IFA22_RS10685	COG2140	Oxalate decarboxylase
IFA22_RS10690	COG1609	Transcriptional regulator
IFA22_RS10705	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IFA22_RS10705	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IFA22_RS10710	COG3715	PTS system
IFA22_RS10715	COG3716	PTS system mannose fructose sorbose family IID component
IFA22_RS10720	COG2942	2-epimerase
IFA22_RS10725	COG3313	Fe-S protein
IFA22_RS10730	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IFA22_RS10735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IFA22_RS10740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IFA22_RS10745	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IFA22_RS10755	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IFA22_RS10780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IFA22_RS10785	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IFA22_RS10790	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IFA22_RS10795	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IFA22_RS10800	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IFA22_RS10805	COG0072	phenylalanine-tRNA ligase activity
IFA22_RS10805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IFA22_RS10810	COG0776	regulation of translation
IFA22_RS10815	COG0784	Response regulator, receiver
IFA22_RS10815	COG2205	protein histidine kinase activity
IFA22_RS10840	COG3300	MHYT domain
IFA22_RS10840	COG5001	Diguanylate cyclase
IFA22_RS10845	COG1609	Transcriptional regulator
IFA22_RS10850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IFA22_RS10855	COG1879	ABC-type sugar transport system periplasmic component
IFA22_RS10860	COG1172	Belongs to the binding-protein-dependent transport system permease family
IFA22_RS10865	COG1129	ABC transporter
IFA22_RS10870	COG1869	D-ribose catabolic process
IFA22_RS10890	COG0037	tRNA processing
IFA22_RS10895	COG0589	response to stress
IFA22_RS10900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IFA22_RS10925	COG2010	Cytochrome c
IFA22_RS10940	COG3278	Belongs to the heme-copper respiratory oxidase family
IFA22_RS10950	COG1956	GAF domain-containing protein
IFA22_RS10955	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IFA22_RS10965	COG0308	aminopeptidase N
IFA22_RS10980	COG0167	dihydroorotate dehydrogenase activity
IFA22_RS10990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IFA22_RS10990	COG0116	Belongs to the methyltransferase superfamily
IFA22_RS11000	COG0488	(ABC) transporter
IFA22_RS11015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IFA22_RS11020	COG1067	ATP-dependent peptidase activity
IFA22_RS11350	COG0372	Belongs to the citrate synthase family
IFA22_RS11355	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IFA22_RS11365	COG2995	paraquat-inducible protein a
IFA22_RS11370	COG3008	intermembrane lipid transfer
IFA22_RS11375	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IFA22_RS11375	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IFA22_RS11405	COG0084	hydrolase, TatD family'
IFA22_RS11410	COG0470	DNA polymerase III
IFA22_RS11415	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IFA22_RS11420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IFA22_RS11425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IFA22_RS11435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IFA22_RS11440	COG1028	Short-chain dehydrogenase reductase Sdr
IFA22_RS11450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IFA22_RS11455	COG0416	fatty acid biosynthetic process
IFA22_RS11460	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IFA22_RS11465	COG1399	metal-binding, possibly nucleic acid-binding protein
IFA22_RS11480	COG2814	Major facilitator Superfamily
IFA22_RS11485	COG0424	maF-like protein
IFA22_RS11490	COG0546	phosphoglycolate phosphatase activity
IFA22_RS11495	COG0564	pseudouridine synthase activity
IFA22_RS11500	COG1530	ribonuclease E activity
IFA22_RS11505	COG0306	phosphate transporter
IFA22_RS11510	COG0717	Belongs to the dCTP deaminase family
IFA22_RS11515	COG0572	uridine kinase
IFA22_RS11520	COG0489	protein tyrosine kinase activity
IFA22_RS11525	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IFA22_RS11525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IFA22_RS11530	COG0625	glutathione transferase activity
IFA22_RS11535	COG1254	Belongs to the acylphosphatase family
IFA22_RS11545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IFA22_RS11545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IFA22_RS11550	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IFA22_RS11565	COG0709	Synthesizes selenophosphate from selenide and ATP
IFA22_RS11570	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
IFA22_RS11575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IFA22_RS11580	COG3437	response regulator, receiver
IFA22_RS11590	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IFA22_RS11600	COG1643	Atp-dependent helicase
IFA22_RS11605	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IFA22_RS11605	COG0617	tRNA 3'-terminal CCA addition
IFA22_RS11605	COG0517	IMP dehydrogenase activity
IFA22_RS11620	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IFA22_RS11630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IFA22_RS11635	COG2832	Protein of unknown function (DUF454)
IFA22_RS11640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IFA22_RS11655	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IFA22_RS11660	COG0318	PFAM AMP-dependent synthetase and ligase
IFA22_RS11665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IFA22_RS11665	COG2226	methyltransferase
IFA22_RS11665	COG0596	Alpha beta hydrolase
IFA22_RS11675	COG1214	PFAM Peptidase M22, glycoprotease
IFA22_RS11680	COG1199	ATP-dependent helicase activity
IFA22_RS11690	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IFA22_RS11695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IFA22_RS11700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IFA22_RS11705	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IFA22_RS11705	COG0131	Imidazoleglycerol-phosphate dehydratase
IFA22_RS11710	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IFA22_RS11715	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IFA22_RS11720	COG3437	response regulator, receiver
IFA22_RS11725	COG2199	diguanylate cyclase activity
IFA22_RS11730	COG2205	protein histidine kinase activity
IFA22_RS11730	COG2198	Histidine kinase
IFA22_RS11730	COG0784	Response regulator, receiver
IFA22_RS11735	COG0107	imidazoleglycerol-phosphate synthase activity
IFA22_RS11740	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IFA22_RS11740	COG0140	phosphoribosyl-ATP diphosphatase activity
IFA22_RS11750	COG0318	PFAM AMP-dependent synthetase and ligase
IFA22_RS11755	COG1288	antiporter activity
IFA22_RS11765	COG3134	Outer membrane lipoprotein
IFA22_RS11775	COG2080	2 iron, 2 sulfur cluster binding
IFA22_RS11780	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IFA22_RS11785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IFA22_RS11790	COG2252	PERMEase
IFA22_RS11795	COG0402	S-adenosylhomocysteine deaminase activity
IFA22_RS11800	COG2233	PERMEase
IFA22_RS11805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IFA22_RS11805	COG2080	2 iron, 2 sulfur cluster binding
IFA22_RS11810	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IFA22_RS11815	COG0402	S-adenosylhomocysteine deaminase activity
IFA22_RS11820	COG0493	'glutamate synthase
IFA22_RS11820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IFA22_RS11825	COG2068	MobA-Related Protein
IFA22_RS11830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IFA22_RS11835	COG3608	succinylglutamate desuccinylase aspartoacylase
IFA22_RS11835	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IFA22_RS11840	COG0697	spore germination
IFA22_RS11845	COG0549	Belongs to the carbamate kinase family
IFA22_RS11855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IFA22_RS11860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IFA22_RS11865	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IFA22_RS11870	COG3829	transcription factor binding
IFA22_RS11890	COG1250	3-hydroxyacyl-CoA dehydrogenase
IFA22_RS11890	COG1024	Enoyl-CoA hydratase
IFA22_RS11895	COG0183	Belongs to the thiolase family
IFA22_RS11900	COG0714	Associated with various cellular activities
IFA22_RS11930	COG1595	DNA-templated transcription, initiation
IFA22_RS11945	COG2067	long-chain fatty acid transport protein
IFA22_RS11950	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IFA22_RS11970	COG3123	guanosine phosphorylase activity
IFA22_RS11975	COG1760	l-serine dehydratase
IFA22_RS11980	COG1760	l-serine dehydratase
IFA22_RS11990	COG5433	transposase activity
IFA22_RS12000	COG3100	YcgL domain-containing protein
IFA22_RS12005	COG0850	regulation of cytokinetic process
IFA22_RS12010	COG2894	cell division
IFA22_RS12015	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IFA22_RS12020	COG3099	Belongs to the UPF0263 family
IFA22_RS12025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IFA22_RS12065	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IFA22_RS12070	COG0697	spore germination
IFA22_RS12075	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IFA22_RS12080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IFA22_RS12090	COG0307	riboflavin synthase, alpha
IFA22_RS12100	COG0534	Mate efflux family protein
IFA22_RS12130	COG0417	DNA replication proofreading
IFA22_RS12155	COG1560	Kdo2-lipid A biosynthetic process
IFA22_RS12160	COG1560	Kdo2-lipid A biosynthetic process
IFA22_RS12170	COG0583	DNA-binding transcription factor activity
IFA22_RS12175	COG0673	inositol 2-dehydrogenase activity
IFA22_RS12180	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IFA22_RS12185	COG0583	DNA-binding transcription factor activity
IFA22_RS12195	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IFA22_RS12205	COG3300	MHYT domain
IFA22_RS12205	COG5001	Diguanylate cyclase
IFA22_RS12210	COG2723	6-phospho-beta-galactosidase activity
IFA22_RS12215	COG0583	DNA-binding transcription factor activity
IFA22_RS12220	COG3706	GGDEF domain
IFA22_RS12235	COG0667	Aldo Keto reductase
IFA22_RS12240	COG0583	DNA-binding transcription factor activity
IFA22_RS12270	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IFA22_RS12310	COG0730	response to heat
IFA22_RS12320	COG1028	Short-chain dehydrogenase reductase Sdr
IFA22_RS12330	COG1024	Enoyl-CoA hydratase
IFA22_RS12335	COG1024	Enoyl-CoA hydratase
IFA22_RS12340	COG1960	acyl-CoA dehydrogenase activity
IFA22_RS12350	COG1960	acyl-CoA dehydrogenase activity
IFA22_RS12355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IFA22_RS12390	COG1584	GPR1 FUN34 yaaH family protein
IFA22_RS12405	COG1115	amino acid carrier protein
IFA22_RS12450	COG1024	Enoyl-CoA hydratase
IFA22_RS12465	COG3162	membrane
IFA22_RS12470	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IFA22_RS12475	COG0488	(ABC) transporter
IFA22_RS12480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IFA22_RS12485	COG0776	regulation of translation
IFA22_RS12490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IFA22_RS12495	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IFA22_RS12500	COG0740	serine-type endopeptidase activity
IFA22_RS12505	COG0544	peptidyl-prolyl cis-trans isomerase activity
IFA22_RS12515	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IFA22_RS12520	COG4591	ABC-type transport system involved in lipoprotein release permease component
IFA22_RS12525	COG1136	(ABC) transporter
IFA22_RS12530	COG4591	ABC-type transport system involved in lipoprotein release permease component
IFA22_RS12540	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IFA22_RS12545	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IFA22_RS12550	COG4166	transmembrane transport
IFA22_RS12555	COG0697	spore germination
IFA22_RS12565	COG2062	phosphohistidine phosphatase, SixA
IFA22_RS12615	COG0519	Catalyzes the synthesis of GMP from XMP
IFA22_RS12615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IFA22_RS12620	COG0516	GMP reductase activity
IFA22_RS12620	COG0517	IMP dehydrogenase activity
IFA22_RS12625	COG3158	transport of potassium into the cell
IFA22_RS12645	COG0697	spore germination
IFA22_RS12650	COG1570	exodeoxyribonuclease VII activity
IFA22_RS12665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IFA22_RS12670	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IFA22_RS12675	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IFA22_RS12715	COG4771	TonB-dependent receptor
IFA22_RS12720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IFA22_RS12725	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IFA22_RS12730	COG1120	ATPase activity
IFA22_RS12740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IFA22_RS12745	COG3033	Beta-eliminating lyase
IFA22_RS12755	COG3046	protein related to deoxyribodipyrimidine photolyase
IFA22_RS12760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IFA22_RS12785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IFA22_RS12790	COG0583	DNA-binding transcription factor activity
IFA22_RS12800	COG4774	siderophore transport
IFA22_RS12815	COG0583	DNA-binding transcription factor activity
IFA22_RS12820	COG2910	NAD(P)H-binding
IFA22_RS12830	COG0626	cystathionine gamma-synthase activity
IFA22_RS12835	COG0612	Peptidase, M16
IFA22_RS12840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IFA22_RS12850	COG1944	ATP diphosphatase activity
IFA22_RS12855	COG2116	formate transmembrane transporter activity
IFA22_RS12860	COG1882	Formate acetyltransferase
IFA22_RS12865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IFA22_RS12870	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IFA22_RS12875	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IFA22_RS12885	COG1840	ABC-type Fe3 transport system, periplasmic component
IFA22_RS12890	COG3842	ATPase activity
IFA22_RS12900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IFA22_RS12925	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IFA22_RS12930	COG0045	succinate-CoA ligase (ADP-forming) activity
IFA22_RS12935	COG0508	dehydrogenase complex catalyzes the overall conversion of
IFA22_RS12940	COG0567	Dehydrogenase, E1 component
IFA22_RS12950	COG1053	succinate dehydrogenase
IFA22_RS12955	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IFA22_RS12980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IFA22_RS12985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IFA22_RS12985	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IFA22_RS12995	COG3069	C4-dicarboxylate transmembrane transporter activity
IFA22_RS13010	COG1451	nucleotide metabolic process
IFA22_RS13025	COG0254	rRNA binding
IFA22_RS13030	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IFA22_RS13040	COG0583	DNA-binding transcription factor activity
IFA22_RS13050	COG1172	Belongs to the binding-protein-dependent transport system permease family
IFA22_RS13060	COG1879	ABC-type sugar transport system periplasmic component
IFA22_RS13065	COG1069	ribulokinase activity
IFA22_RS13075	COG2160	L-arabinose isomerase activity
IFA22_RS13080	COG2925	Exonuclease
IFA22_RS13090	COG3345	alpha-galactosidase
IFA22_RS13095	COG1380	Effector of murein hydrolase LrgA
IFA22_RS13100	COG1346	cytolysis
IFA22_RS13105	COG0295	cytidine deaminase activity
IFA22_RS13110	COG1022	Amp-dependent synthetase and ligase
IFA22_RS13125	COG0861	Integral membrane protein TerC family
IFA22_RS13130	COG2885	chlorophyll binding
IFA22_RS13135	COG2199	diguanylate cyclase activity
IFA22_RS13155	COG2154	pterin-4-alpha-carbinolamine dehydratase
IFA22_RS13165	COG3768	UPF0283 membrane protein
IFA22_RS13170	COG3106	COG3106 Predicted ATPase
IFA22_RS13185	COG1842	Phage shock protein A
IFA22_RS13190	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IFA22_RS13200	COG4168	peptide transport system, permease
IFA22_RS13205	COG4171	peptide transport system, permease
IFA22_RS13215	COG4172	Belongs to the ABC transporter superfamily
IFA22_RS13225	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IFA22_RS13230	COG1286	toxin biosynthetic process
IFA22_RS13235	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IFA22_RS13240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IFA22_RS13245	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IFA22_RS13250	COG0531	amino acid
IFA22_RS13250	COG1674	ftsk spoiiie
IFA22_RS13260	COG0686	Belongs to the AlaDH PNT family
IFA22_RS13265	COG0492	ferredoxin-NADP+ reductase activity
IFA22_RS13270	COG3706	GGDEF domain
IFA22_RS13275	COG3134	Outer membrane lipoprotein
IFA22_RS13280	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IFA22_RS13285	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IFA22_RS13290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IFA22_RS13295	COG0542	response to heat
IFA22_RS13300	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IFA22_RS13305	COG1278	Cold shock
IFA22_RS13310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IFA22_RS13375	COG3829	transcription factor binding
IFA22_RS13450	COG3501	Rhs element vgr protein
IFA22_RS13480	COG1435	thymidine kinase activity
IFA22_RS13485	COG1757	Na H antiporter
IFA22_RS13490	COG2916	Histone family protein nucleoid-structuring protein H-NS
IFA22_RS13495	COG2096	Adenosyltransferase
IFA22_RS13500	COG3530	Putative quorum-sensing-regulated virulence factor
IFA22_RS13505	COG0602	queuosine metabolic process
IFA22_RS13510	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IFA22_RS13530	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IFA22_RS13540	COG0776	regulation of translation
IFA22_RS13545	COG0539	negative regulation of cytoplasmic translation
IFA22_RS13550	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IFA22_RS13555	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IFA22_RS13565	COG0583	DNA-binding transcription factor activity
IFA22_RS13585	COG0778	Nitroreductase
IFA22_RS13590	COG5001	Diguanylate cyclase
IFA22_RS13590	COG3300	MHYT domain
IFA22_RS13605	COG3437	response regulator, receiver
IFA22_RS13630	COG4989	oxidoreductase activity
IFA22_RS13635	COG5433	transposase activity
IFA22_RS13640	COG0724	RNA recognition motif
IFA22_RS13660	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IFA22_RS13690	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IFA22_RS13695	COG1360	Flagellar Motor Protein
IFA22_RS13700	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IFA22_RS13705	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IFA22_RS13710	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IFA22_RS13710	COG0649	NAD binding
IFA22_RS13725	COG1034	ATP synthesis coupled electron transport
IFA22_RS13730	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IFA22_RS13735	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IFA22_RS13740	COG0839	Belongs to the complex I subunit 6 family
IFA22_RS13745	COG0713	ATP synthesis coupled electron transport
IFA22_RS13755	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IFA22_RS13760	COG1007	ATP synthesis coupled electron transport
IFA22_RS13775	COG2199	diguanylate cyclase activity
IFA22_RS13775	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IFA22_RS13780	COG0047	phosphoribosylformylglycinamidine synthase activity
IFA22_RS13780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IFA22_RS13785	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IFA22_RS13790	COG1645	bacterial-type flagellum-dependent swarming motility
IFA22_RS13795	COG1160	GTP binding
IFA22_RS13800	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IFA22_RS13805	COG2976	Protein conserved in bacteria
IFA22_RS13810	COG0124	histidyl-tRNA synthetase
IFA22_RS13815	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IFA22_RS13830	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IFA22_RS13835	COG0105	UTP biosynthetic process
IFA22_RS13840	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IFA22_RS13850	COG0633	Ferredoxin
IFA22_RS13855	COG0443	Heat shock 70 kDa protein
IFA22_RS13860	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IFA22_RS13870	COG0822	iron-sulfur transferase activity
IFA22_RS13875	COG1104	cysteine desulfurase activity
IFA22_RS13895	COG3154	lipid carrier protein
IFA22_RS13900	COG0826	peptidase U32
IFA22_RS13905	COG0826	peptidase U32
IFA22_RS13920	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IFA22_RS13925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IFA22_RS13930	COG1862	Preprotein translocase
IFA22_RS13935	COG0343	queuine tRNA-ribosyltransferase activity
IFA22_RS13940	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IFA22_RS13945	COG0517	IMP dehydrogenase activity
IFA22_RS13955	COG3634	alkyl hydroperoxide reductase activity
IFA22_RS13975	COG1393	Belongs to the ArsC family
IFA22_RS13980	COG0798	PFAM Bile acid sodium symporter
IFA22_RS13985	COG0640	Transcriptional regulator
IFA22_RS14010	COG3385	transposase activity
IFA22_RS14045	COG5433	transposase activity
IFA22_RS14105	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IFA22_RS14105	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IFA22_RS14110	COG0509	glycine decarboxylation via glycine cleavage system
IFA22_RS14115	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IFA22_RS14120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IFA22_RS14125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IFA22_RS14145	COG2814	Major facilitator Superfamily
IFA22_RS14150	COG0625	glutathione transferase activity
IFA22_RS14160	COG0483	inositol monophosphate 1-phosphatase activity
IFA22_RS14180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IFA22_RS14190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IFA22_RS14195	COG1086	Polysaccharide biosynthesis protein
IFA22_RS14225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IFA22_RS14245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IFA22_RS14245	COG0301	tRNA thio-modification
IFA22_RS14255	COG4953	penicillin-binding protein 1C
IFA22_RS14260	COG2373	Large extracellular alpha-helical protein
IFA22_RS14270	COG0628	permease
IFA22_RS14275	COG1538	Outer membrane efflux protein
IFA22_RS14295	COG0446	pyridine nucleotide-disulphide oxidoreductase
IFA22_RS14305	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IFA22_RS14325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IFA22_RS14335	COG2431	L-lysine efflux transmembrane transporter activity
IFA22_RS14340	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IFA22_RS14345	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
IFA22_RS14365	COG1393	Belongs to the ArsC family
IFA22_RS14375	COG4783	chaperone-mediated protein folding
IFA22_RS14380	COG0425	Belongs to the sulfur carrier protein TusA family
IFA22_RS14405	COG3842	ATPase activity
IFA22_RS14410	COG3833	ABC-type maltose transport systems, permease component
IFA22_RS14415	COG1175	transmembrane transport
IFA22_RS14425	COG3081	Nucleoid-associated protein
IFA22_RS14430	COG3082	Protein of unknown function (DUF1414)
IFA22_RS14435	COG3083	sulfuric ester hydrolase activity
IFA22_RS14440	COG4771	TonB-dependent receptor
IFA22_RS14445	COG1770	oligopeptidase
IFA22_RS14465	COG4574	serine-type endopeptidase inhibitor activity
IFA22_RS14470	COG3085	chromosome segregation
IFA22_RS14475	COG0583	DNA-binding transcription factor activity
IFA22_RS14480	COG1605	Chorismate mutase
IFA22_RS14480	COG0287	Prephenate dehydrogenase
IFA22_RS14485	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IFA22_RS14490	COG0584	glycerophosphoryl diester phosphodiesterase
IFA22_RS14500	COG1349	DNA-binding transcription factor activity
IFA22_RS14520	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IFA22_RS14525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IFA22_RS14530	COG0583	DNA-binding transcription factor activity
IFA22_RS14555	COG0656	L-ascorbic acid biosynthetic process
IFA22_RS14560	COG2814	Major facilitator Superfamily
IFA22_RS14570	COG1294	oxidase, subunit
IFA22_RS14575	COG1271	oxidase subunit
IFA22_RS14580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IFA22_RS14590	COG2979	Protein of unknown function (DUF533)
IFA22_RS14620	COG2271	Major facilitator Superfamily
IFA22_RS14625	COG0583	DNA-binding transcription factor activity
IFA22_RS14635	COG2807	transmembrane transport
IFA22_RS14640	COG1187	pseudouridine synthase activity
IFA22_RS14655	COG0346	lactoylglutathione lyase activity
IFA22_RS14665	COG1403	HNH endonuclease
IFA22_RS14675	COG2964	Protein conserved in bacteria
IFA22_RS14680	COG3681	Belongs to the UPF0597 family
IFA22_RS14690	COG0814	amino acid
IFA22_RS14710	COG1166	arginine decarboxylase activity
IFA22_RS14720	COG2195	Cleaves the N-terminal amino acid of tripeptides
IFA22_RS14750	COG0583	DNA-binding transcription factor activity
IFA22_RS14760	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IFA22_RS14765	COG0840	transmembrane signaling receptor activity
IFA22_RS14770	COG0302	gtp cyclohydrolase
IFA22_RS14780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IFA22_RS14785	COG2267	carboxylic ester hydrolase activity
IFA22_RS14790	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IFA22_RS14805	COG0314	molybdopterin synthase activity
IFA22_RS14810	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IFA22_RS14815	COG0315	cyclic pyranopterin monophosphate synthase activity
IFA22_RS14820	COG0521	Mo-molybdopterin cofactor biosynthetic process
IFA22_RS14825	COG3005	denitrification pathway
IFA22_RS14835	COG0348	domain, Protein
IFA22_RS14840	COG0437	4 iron, 4 sulfur cluster binding
IFA22_RS14845	COG0243	molybdopterin cofactor binding
IFA22_RS14855	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
IFA22_RS14855	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IFA22_RS14860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IFA22_RS14865	COG3850	Histidine kinase
IFA22_RS14870	COG2197	response regulator
IFA22_RS14900	COG0121	glutamine amidotransferase
IFA22_RS14905	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IFA22_RS14910	COG1960	acyl-CoA dehydrogenase activity
IFA22_RS14930	COG0328	RNA-DNA hybrid ribonuclease activity
IFA22_RS14935	COG2226	methyltransferase
IFA22_RS14940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IFA22_RS14945	COG1388	LysM domain
IFA22_RS14945	COG0741	lytic transglycosylase activity
IFA22_RS14950	COG3021	interspecies interaction between organisms
IFA22_RS14960	COG1607	acyl-coa hydrolase
IFA22_RS14975	COG0741	lytic transglycosylase activity
IFA22_RS14985	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IFA22_RS15005	COG2911	Protein conserved in bacteria
IFA22_RS15010	COG0729	surface antigen
IFA22_RS15020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IFA22_RS15025	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IFA22_RS15035	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IFA22_RS15045	COG4134	Bacterial extracellular solute-binding protein
IFA22_RS15055	COG4136	ATPase activity
IFA22_RS15060	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IFA22_RS15065	COG2951	lytic endotransglycosylase activity
IFA22_RS15080	COG1846	Transcriptional regulator
IFA22_RS15090	COG0033	Phosphoglucomutase
IFA22_RS15095	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
IFA22_RS15100	COG0596	Alpha beta hydrolase
IFA22_RS15115	COG0716	FMN binding
IFA22_RS15125	COG0735	belongs to the Fur family
IFA22_RS15130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IFA22_RS15140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IFA22_RS15140	COG2190	(PTS) system
IFA22_RS15140	COG1263	PTS System
IFA22_RS15145	COG0363	glucosamine-6-phosphate deaminase activity
IFA22_RS15150	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IFA22_RS15155	COG1846	Transcriptional regulator
IFA22_RS15155	COG1940	carbohydrate kinase activity
IFA22_RS15160	COG2194	sulfuric ester hydrolase activity
IFA22_RS15165	COG0217	transcriptional regulatory protein
IFA22_RS15170	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IFA22_RS15175	COG1801	Protein of unknown function DUF72
IFA22_RS15180	COG4106	trans-aconitate 2-methyltransferase activity
IFA22_RS15185	COG0500	methyltransferase
IFA22_RS15205	COG0450	alkyl hydroperoxide reductase
IFA22_RS15210	COG0583	DNA-binding transcription factor activity
IFA22_RS15220	COG0791	NLP P60 protein
IFA22_RS15235	COG1309	transcriptional regulator
IFA22_RS15275	COG0534	Mate efflux family protein
IFA22_RS15295	COG2366	antibiotic biosynthetic process
IFA22_RS15300	COG1013	pyruvate-flavodoxin oxidoreductase activity
IFA22_RS15300	COG0674	pyruvate-flavodoxin oxidoreductase activity
IFA22_RS15300	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IFA22_RS15300	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IFA22_RS15310	COG0633	Ferredoxin
IFA22_RS15310	COG3217	Mosc domain protein beta barrel domain protein
IFA22_RS15310	COG0633	Ferredoxin
IFA22_RS15310	COG3217	Mosc domain protein beta barrel domain protein
IFA22_RS15320	COG0501	Belongs to the peptidase M48B family
IFA22_RS15330	COG1073	alpha beta
IFA22_RS15330	COG2226	methyltransferase
IFA22_RS15335	COG0156	8-amino-7-oxononanoate synthase activity
IFA22_RS15340	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IFA22_RS15360	COG0017	Asparaginyl-tRNA synthetase
IFA22_RS15365	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IFA22_RS15380	COG3069	C4-dicarboxylate transmembrane transporter activity
IFA22_RS15390	COG0583	DNA-binding transcription factor activity
IFA22_RS15420	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IFA22_RS15425	COG1393	Belongs to the ArsC family
IFA22_RS15430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IFA22_RS15435	COG1876	peptidase activity
IFA22_RS15445	COG3263	regulation of cellular component size
IFA22_RS15465	COG1280	lysine exporter protein (LysE YggA)
IFA22_RS15490	COG1957	nucleoside hydrolase
IFA22_RS15495	COG0564	pseudouridine synthase activity
IFA22_RS15505	COG1454	alcohol dehydrogenase
IFA22_RS15510	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IFA22_RS15515	COG0702	epimerase
IFA22_RS15520	COG2914	Belongs to the UPF0125 (RnfH) family
IFA22_RS15525	COG2867	negative regulation of translational initiation
IFA22_RS15530	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IFA22_RS15540	COG0582	viral genome integration into host DNA
IFA22_RS15585	COG1695	Transcriptional regulator
IFA22_RS15600	COG5433	transposase activity
IFA22_RS15620	COG4584	PFAM Integrase catalytic
IFA22_RS15625	COG1484	DNA-dependent DNA replication
IFA22_RS15635	COG1609	Transcriptional regulator
IFA22_RS15665	COG2916	Histone family protein nucleoid-structuring protein H-NS
IFA22_RS15670	COG5433	transposase activity
IFA22_RS15675	COG3311	Transcriptional regulator
IFA22_RS15695	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IFA22_RS15700	COG0583	DNA-binding transcription factor activity
IFA22_RS15705	COG2610	gluconate transmembrane transporter activity
IFA22_RS15710	COG3048	D-serine ammonia-lyase activity
IFA22_RS15720	COG0538	isocitrate dehydrogenase activity
IFA22_RS15725	COG2207	Transcriptional regulator
IFA22_RS15745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IFA22_RS15760	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IFA22_RS15765	COG1263	PTS System
IFA22_RS15765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IFA22_RS15770	COG1609	Transcriptional regulator
IFA22_RS15780	COG0789	Transcriptional regulator
IFA22_RS15800	COG0456	acetyltransferase
IFA22_RS15820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IFA22_RS15820	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IFA22_RS15820	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IFA22_RS15830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IFA22_RS15830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IFA22_RS15830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IFA22_RS15840	COG1187	pseudouridine synthase activity
IFA22_RS15850	COG0482	sulfurtransferase activity
IFA22_RS15855	COG2915	High frequency lysogenization protein hflD homolog
IFA22_RS15860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IFA22_RS15865	COG2850	peptidyl-arginine hydroxylation
IFA22_RS15870	COG3153	acetyltransferase
IFA22_RS15880	COG0625	glutathione transferase activity
IFA22_RS15885	COG0259	pyridoxamine-phosphate oxidase activity
IFA22_RS15900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IFA22_RS15900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IFA22_RS15905	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IFA22_RS15920	COG4235	cytochrome complex assembly
IFA22_RS15920	COG3088	subunit of a heme lyase
IFA22_RS15925	COG3088	subunit of a heme lyase
IFA22_RS15925	COG4235	cytochrome complex assembly
IFA22_RS15930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IFA22_RS15935	COG1138	Cytochrome C-type biogenesis protein
IFA22_RS15940	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IFA22_RS15945	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IFA22_RS15950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IFA22_RS15955	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IFA22_RS15970	COG0835	chemotaxis
IFA22_RS15980	COG1192	Involved in chromosome partitioning
IFA22_RS15985	COG1360	Flagellar Motor Protein
IFA22_RS15990	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IFA22_RS15995	COG2201	protein-glutamate methylesterase activity
IFA22_RS16000	COG2198	Histidine kinase
IFA22_RS16000	COG0784	Response regulator, receiver
IFA22_RS16000	COG0643	Histidine kinase
IFA22_RS16005	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
IFA22_RS16040	COG1684	flagellar biosynthetic protein fliR
IFA22_RS16095	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IFA22_RS16105	COG1677	Flagellar hook-basal body complex protein FliE
IFA22_RS16140	COG5642	Protein of unknown function (DUF2384)
IFA22_RS16155	COG5433	transposase activity
IFA22_RS16170	COG1538	Outer membrane efflux protein
IFA22_RS16185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IFA22_RS16195	COG0745	RESPONSE REGULATOR receiver
IFA22_RS16200	COG5002	protein histidine kinase activity
IFA22_RS16230	COG2132	Multicopper oxidase
IFA22_RS16325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IFA22_RS16330	COG3064	Membrane
IFA22_RS16330	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IFA22_RS16330	COG1073	alpha beta
IFA22_RS16335	COG2994	toxin metabolic process
IFA22_RS16345	COG2274	protein secretion by the type I secretion system
IFA22_RS16355	COG2274	protein secretion by the type I secretion system
IFA22_RS16375	COG1737	Transcriptional regulator
IFA22_RS16380	COG0469	pyruvate kinase activity
IFA22_RS16390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IFA22_RS16395	COG1960	acyl-CoA dehydrogenase activity
IFA22_RS16405	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IFA22_RS16420	COG5377	YqaJ viral recombinase family
IFA22_RS16440	COG2003	Belongs to the UPF0758 family
IFA22_RS16490	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IFA22_RS16500	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IFA22_RS16510	COG1196	nuclear chromosome segregation
IFA22_RS16530	COG5433	transposase activity
IFA22_RS16545	COG0582	viral genome integration into host DNA
IFA22_RS16550	COG0243	molybdopterin cofactor binding
IFA22_RS16560	COG0583	DNA-binding transcription factor activity
IFA22_RS16595	COG1012	belongs to the aldehyde dehydrogenase family
IFA22_RS16595	COG1454	alcohol dehydrogenase
IFA22_RS16605	COG1454	alcohol dehydrogenase
IFA22_RS16605	COG1012	belongs to the aldehyde dehydrogenase family
IFA22_RS16610	COG1882	Formate acetyltransferase
IFA22_RS16615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IFA22_RS16625	COG4869	propanediol catabolic process
IFA22_RS16650	COG1376	ErfK ybiS ycfS ynhG family protein
IFA22_RS16650	COG1388	LysM domain
IFA22_RS16665	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
IFA22_RS16670	COG0791	NLP P60 protein
IFA22_RS16680	COG3118	belongs to the thioredoxin family
IFA22_RS16690	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IFA22_RS16695	COG0788	formyltetrahydrofolate deformylase activity
IFA22_RS16705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IFA22_RS16725	COG0366	Alpha amylase catalytic
IFA22_RS16730	COG0739	heme binding
IFA22_RS16730	COG0741	lytic transglycosylase activity
IFA22_RS16730	COG1196	nuclear chromosome segregation
IFA22_RS16735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IFA22_RS16740	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IFA22_RS16750	COG0673	inositol 2-dehydrogenase activity
IFA22_RS16770	COG3152	Membrane
IFA22_RS16785	COG3039	Transposase
IFA22_RS16800	COG1032	radical SAM domain protein
IFA22_RS16810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IFA22_RS16815	COG1566	PFAM secretion protein HlyD family protein
IFA22_RS16825	COG1752	Esterase of the alpha-beta hydrolase superfamily
IFA22_RS16830	COG0733	neurotransmitter:sodium symporter activity
IFA22_RS16870	COG0281	malic enzyme
IFA22_RS16880	COG0534	Mate efflux family protein
IFA22_RS16895	COG2233	PERMEase
IFA22_RS16900	COG0095	Lipoate-protein ligase
IFA22_RS16905	COG1115	amino acid carrier protein
IFA22_RS16910	COG0019	diaminopimelate decarboxylase activity
IFA22_RS16930	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IFA22_RS16950	COG1131	(ABC) transporter
IFA22_RS16955	COG0545	Peptidyl-prolyl cis-trans isomerase
IFA22_RS16965	COG3142	Participates in the control of copper homeostasis
IFA22_RS16990	COG5002	protein histidine kinase activity
IFA22_RS16995	COG0745	RESPONSE REGULATOR receiver
IFA22_RS17000	COG0346	lactoylglutathione lyase activity
IFA22_RS17005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IFA22_RS17010	COG1960	acyl-CoA dehydrogenase activity
IFA22_RS17015	COG3284	Transcriptional regulator
IFA22_RS17030	COG0697	spore germination
IFA22_RS17060	COG4565	transcriptional regulatory protein
IFA22_RS17065	COG3290	protein histidine kinase activity
IFA22_RS17070	COG0281	malic enzyme
IFA22_RS17085	COG1846	Transcriptional regulator
IFA22_RS17090	COG1566	PFAM secretion protein HlyD family protein
IFA22_RS17120	COG0602	queuosine metabolic process
IFA22_RS17125	COG1328	CTP reductase activity
IFA22_RS17135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IFA22_RS17140	COG3115	cell septum assembly
IFA22_RS17145	COG1196	nuclear chromosome segregation
IFA22_RS17155	COG2860	membrane
IFA22_RS17165	COG3108	Peptidase M15
IFA22_RS17170	COG2989	Protein conserved in bacteria
IFA22_RS17185	COG0463	Glycosyl transferase, family 2
IFA22_RS17200	COG0366	Alpha amylase catalytic
IFA22_RS17235	COG3706	GGDEF domain
IFA22_RS17245	COG3590	peptidase
IFA22_RS17255	COG0488	(ABC) transporter
IFA22_RS17265	COG0531	amino acid
IFA22_RS17275	COG1234	tRNA 3'-trailer cleavage
IFA22_RS17280	COG0814	amino acid
IFA22_RS17295	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IFA22_RS17300	COG1982	Orn Lys Arg decarboxylase major
IFA22_RS17305	COG0531	amino acid
IFA22_RS17310	COG3710	Transcriptional regulator
IFA22_RS17315	COG0825	malonyl-CoA metabolic process
IFA22_RS17325	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IFA22_RS17330	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IFA22_RS17335	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IFA22_RS17340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IFA22_RS17345	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IFA22_RS17360	COG0750	zinc metalloprotease
IFA22_RS17365	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IFA22_RS17370	COG0575	Belongs to the CDS family
IFA22_RS17375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IFA22_RS17380	COG0233	cytoplasmic translational termination
IFA22_RS17385	COG0528	UMP kinase activity
IFA22_RS17390	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IFA22_RS17395	COG0052	Belongs to the universal ribosomal protein uS2 family
IFA22_RS17400	COG0024	Methionine aminopeptidase
IFA22_RS17405	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IFA22_RS17410	COG2171	N-acyltransferase activity
IFA22_RS17420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IFA22_RS17420	COG1263	PTS System
IFA22_RS17440	COG0564	pseudouridine synthase activity
IFA22_RS17445	COG3098	single-species biofilm formation
IFA22_RS17470	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
IFA22_RS17480	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IFA22_RS17480	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IFA22_RS17495	COG1611	Belongs to the LOG family
IFA22_RS17500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IFA22_RS17505	COG0473	3-isopropylmalate dehydrogenase activity
IFA22_RS17515	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IFA22_RS17520	COG2363	Small membrane protein
IFA22_RS17530	COG0583	DNA-binding transcription factor activity
IFA22_RS17535	COG0840	transmembrane signaling receptor activity
IFA22_RS17540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IFA22_RS17555	COG1477	protein flavinylation
IFA22_RS17560	COG2871	sodium ion transport
IFA22_RS17565	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IFA22_RS17570	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IFA22_RS17575	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IFA22_RS17580	COG1805	sodium ion transport
IFA22_RS17585	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IFA22_RS17590	COG0271	Belongs to the BolA IbaG family
IFA22_RS17595	COG2813	Specifically methylates the guanine in position
IFA22_RS17605	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IFA22_RS17615	COG2211	Major facilitator Superfamily
IFA22_RS17620	COG3248	Nucleoside-binding outer membrane protein
IFA22_RS17625	COG1666	GTP binding
IFA22_RS17630	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IFA22_RS17635	COG0693	protein deglycase activity
IFA22_RS17705	COG2771	luxR family
IFA22_RS17715	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IFA22_RS17715	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IFA22_RS17720	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IFA22_RS17730	COG1151	hydroxylamine reductase activity
IFA22_RS17735	COG0783	Belongs to the Dps family
IFA22_RS17760	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IFA22_RS17775	COG4221	oxidoreductase activity
IFA22_RS17785	COG0415	Belongs to the DNA photolyase family
IFA22_RS17790	COG0789	Transcriptional regulator
IFA22_RS17795	COG3272	Protein of unknown function (DUF1722)
IFA22_RS17825	COG1605	Chorismate mutase
IFA22_RS17825	COG0077	Prephenate dehydratase
IFA22_RS17855	COG5377	YqaJ viral recombinase family
IFA22_RS17900	COG2003	Belongs to the UPF0758 family
IFA22_RS17955	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IFA22_RS17985	COG3385	transposase activity
IFA22_RS18055	COG0625	glutathione transferase activity
IFA22_RS18060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IFA22_RS18080	COG1484	DNA-dependent DNA replication
IFA22_RS18085	COG4584	PFAM Integrase catalytic
IFA22_RS18105	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IFA22_RS18150	COG2133	pyrroloquinoline quinone binding
IFA22_RS18160	COG0840	transmembrane signaling receptor activity
IFA22_RS18170	COG0300	oxidoreductase activity
IFA22_RS18195	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IFA22_RS18210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IFA22_RS18220	COG0826	peptidase U32
IFA22_RS18225	COG1280	lysine exporter protein (LysE YggA)
IFA22_RS18235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IFA22_RS18240	COG0840	transmembrane signaling receptor activity
IFA22_RS18255	COG2198	Histidine kinase
IFA22_RS18255	COG0643	Histidine kinase
IFA22_RS18265	COG0835	chemotaxis
IFA22_RS18270	COG0840	transmembrane signaling receptor activity
IFA22_RS18280	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IFA22_RS18285	COG2201	protein-glutamate methylesterase activity
IFA22_RS18290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IFA22_RS18320	COG2197	response regulator
IFA22_RS18345	COG2199	diguanylate cyclase activity
IFA22_RS18345	COG2203	Gaf domain
IFA22_RS18345	COG2200	EAL domain
IFA22_RS18350	COG0826	peptidase U32
IFA22_RS18355	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IFA22_RS18365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IFA22_RS18380	COG2200	EAL domain
IFA22_RS18385	COG0737	Belongs to the 5'-nucleotidase family
IFA22_RS18405	COG2204	response regulator
IFA22_RS18410	COG0545	Peptidyl-prolyl cis-trans isomerase
IFA22_RS18425	COG1047	Peptidyl-prolyl cis-trans
IFA22_RS18430	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IFA22_RS18440	COG0784	Response regulator, receiver
IFA22_RS18440	COG0835	chemotaxis
IFA22_RS18445	COG0429	hydrolase of the alpha beta-hydrolase fold
IFA22_RS18450	COG3706	GGDEF domain
IFA22_RS18450	COG2203	Gaf domain
IFA22_RS18450	COG4251	negative regulation of phosphorylation
IFA22_RS18450	COG5001	Diguanylate cyclase
IFA22_RS18455	COG3089	Belongs to the UPF0270 family
IFA22_RS18470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IFA22_RS18475	COG0463	Glycosyl transferase, family 2
IFA22_RS18480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IFA22_RS18480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IFA22_RS18485	COG0726	polysaccharide deacetylase
IFA22_RS18490	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IFA22_RS18495	COG2076	Multidrug Resistance protein
IFA22_RS18500	COG2076	Multidrug Resistance protein
IFA22_RS18505	COG3954	Phosphoribulokinase
IFA22_RS18520	COG1765	OsmC-like protein
IFA22_RS18530	COG2226	methyltransferase
IFA22_RS18535	COG3397	chitin binding
IFA22_RS18550	COG2205	protein histidine kinase activity
IFA22_RS18550	COG2202	Pas domain
IFA22_RS18560	COG3655	Transcriptional regulator
IFA22_RS18565	COG2814	Major facilitator Superfamily
IFA22_RS18570	COG4771	TonB-dependent receptor
IFA22_RS18590	COG0748	coenzyme F420 binding
IFA22_RS18595	COG3721	Heme iron utilization protein
IFA22_RS18605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IFA22_RS18630	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IFA22_RS18635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IFA22_RS18640	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IFA22_RS18660	COG0741	lytic transglycosylase activity
IFA22_RS18665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IFA22_RS18680	COG0488	(ABC) transporter
IFA22_RS18690	COG2252	PERMEase
IFA22_RS18695	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IFA22_RS18700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IFA22_RS18705	COG3178	'Phosphotransferase
IFA22_RS18710	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IFA22_RS18720	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IFA22_RS18725	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IFA22_RS18730	COG2967	ApaG domain
IFA22_RS18735	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IFA22_RS18745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IFA22_RS18750	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IFA22_RS18765	COG0318	PFAM AMP-dependent synthetase and ligase
IFA22_RS18770	COG3314	Sporulation integral membrane protein YlbJ
IFA22_RS18780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IFA22_RS18785	COG0840	transmembrane signaling receptor activity
IFA22_RS18795	COG1278	Cold shock
IFA22_RS18830	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IFA22_RS18835	COG1162	GTPase activity
IFA22_RS18840	COG0688	phosphatidylethanolamine metabolic process
IFA22_RS18845	COG4628	conserved protein (DUF2132)
IFA22_RS18860	COG3059	membrane
IFA22_RS18865	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IFA22_RS18870	COG2207	Transcriptional regulator
IFA22_RS18880	COG5001	Diguanylate cyclase
IFA22_RS18880	COG3300	MHYT domain
IFA22_RS18885	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
IFA22_RS18905	COG3039	Transposase
IFA22_RS18930	COG4974	Belongs to the 'phage' integrase family
IFA22_RS18935	COG3385	transposase activity
IFA22_RS18940	COG5001	Diguanylate cyclase
IFA22_RS18940	COG3447	MASE1 domain protein
IFA22_RS18940	COG5002	protein histidine kinase activity
IFA22_RS18960	COG0582	viral genome integration into host DNA
IFA22_RS18980	COG1132	(ABC) transporter
IFA22_RS18990	COG1404	Belongs to the peptidase S8 family
IFA22_RS18995	COG2897	thiosulfate sulfurtransferase activity
IFA22_RS19000	COG2066	Belongs to the glutaminase family
IFA22_RS19005	COG3171	Protein conserved in bacteria
IFA22_RS19010	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IFA22_RS19015	COG4935	Belongs to the peptidase S8 family
IFA22_RS19015	COG2234	aminopeptidase activity
IFA22_RS19020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IFA22_RS19025	COG2200	EAL domain
IFA22_RS19030	COG1090	epimerase
IFA22_RS19035	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IFA22_RS19040	COG4181	ATPase activity
IFA22_RS19045	COG2755	lipolytic protein G-D-S-L family
IFA22_RS19050	COG0835	chemotaxis
IFA22_RS19050	COG0784	Response regulator, receiver
IFA22_RS19075	COG0569	domain protein
IFA22_RS19075	COG2985	domain, Protein
IFA22_RS19080	COG1272	protein, Hemolysin III
IFA22_RS19085	COG0076	glutamate decarboxylase activity
IFA22_RS19090	COG2917	probably involved in intracellular septation
IFA22_RS19095	COG2350	Protein conserved in bacteria
IFA22_RS19105	COG1555	photosystem II stabilization
IFA22_RS19110	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IFA22_RS19115	COG3104	oligopeptide transport
IFA22_RS19120	COG0745	RESPONSE REGULATOR receiver
IFA22_RS19150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IFA22_RS19165	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IFA22_RS19180	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IFA22_RS19190	COG1136	(ABC) transporter
IFA22_RS19270	COG2003	Belongs to the UPF0758 family
IFA22_RS19330	COG1401	restriction endodeoxyribonuclease activity
IFA22_RS19335	COG5433	transposase activity
IFA22_RS19355	COG3311	Transcriptional regulator
IFA22_RS19370	COG1280	lysine exporter protein (LysE YggA)
IFA22_RS19395	COG0316	Belongs to the HesB IscA family
IFA22_RS19405	COG0038	chloride channel
IFA22_RS19410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IFA22_RS19425	COG0671	phosphoesterase, PA-phosphatase related
IFA22_RS19435	COG3437	response regulator, receiver
IFA22_RS19435	COG0784	Response regulator, receiver
IFA22_RS19445	COG2076	Multidrug Resistance protein
IFA22_RS19455	COG0346	lactoylglutathione lyase activity
IFA22_RS19460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IFA22_RS19465	COG1643	Atp-dependent helicase
IFA22_RS19475	COG1489	DNA binding
IFA22_RS19480	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IFA22_RS19485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IFA22_RS19500	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IFA22_RS19505	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IFA22_RS19525	COG1924	4 iron, 4 sulfur cluster binding
IFA22_RS19530	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
IFA22_RS19535	COG0842	Transport permease protein
IFA22_RS19540	COG1131	(ABC) transporter
IFA22_RS19555	COG0163	prenyltransferase activity
IFA22_RS19560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IFA22_RS19565	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IFA22_RS19580	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IFA22_RS19595	COG1136	(ABC) transporter
IFA22_RS19615	COG0840	transmembrane signaling receptor activity
IFA22_RS19630	COG0529	Catalyzes the synthesis of activated sulfate
IFA22_RS19635	COG0471	metal ion transport
IFA22_RS19635	COG3273	potassium ion transport
IFA22_RS19640	COG2895	sulfate adenylyltransferase (ATP) activity
IFA22_RS19645	COG0175	sulfate reduction
IFA22_RS19650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IFA22_RS19650	COG1648	precorrin-2 dehydrogenase activity
IFA22_RS19655	COG0330	HflC and HflK could
IFA22_RS19660	COG1585	Membrane protein implicated in regulation of membrane protease activity
IFA22_RS19665	COG0517	IMP dehydrogenase activity
IFA22_RS19665	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IFA22_RS19670	COG0488	(ABC) transporter
IFA22_RS19680	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IFA22_RS19710	COG5433	transposase activity
IFA22_RS19740	COG0789	Transcriptional regulator
IFA22_RS19750	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IFA22_RS19760	COG0668	transmembrane transport
IFA22_RS19770	COG2731	YhcH YjgK YiaL family protein
IFA22_RS19780	COG2132	Multicopper oxidase
IFA22_RS19785	COG1794	racemase activity, acting on amino acids and derivatives
IFA22_RS19800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IFA22_RS19825	COG0733	neurotransmitter:sodium symporter activity
IFA22_RS19835	COG0733	neurotransmitter:sodium symporter activity
IFA22_RS19850	COG0561	phosphatase activity
IFA22_RS19885	COG1846	Transcriptional regulator
IFA22_RS19890	COG1764	response to oxidative stress
IFA22_RS19895	COG2130	NADP-dependent
IFA22_RS19900	COG1051	belongs to the nudix hydrolase family
IFA22_RS19920	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IFA22_RS19925	COG1640	4-alpha-glucanotransferase
IFA22_RS19930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IFA22_RS19935	COG0676	glucose-6-phosphate 1-epimerase activity
IFA22_RS19940	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IFA22_RS19945	COG0840	transmembrane signaling receptor activity
IFA22_RS20020	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IFA22_RS20025	COG2885	chlorophyll binding
IFA22_RS20030	COG0823	Involved in the tonB-independent uptake of proteins
IFA22_RS20045	COG0811	peptide transport
IFA22_RS20050	COG0824	Thioesterase
IFA22_RS20055	COG3790	cyd operon protein YbgE
IFA22_RS20060	COG4890	Cyd operon protein YbgT
IFA22_RS20065	COG1294	oxidase, subunit
IFA22_RS20070	COG1271	oxidase subunit
IFA22_RS20075	COG2255	four-way junction helicase activity
IFA22_RS20080	COG0632	four-way junction helicase activity
IFA22_RS20085	COG0840	transmembrane signaling receptor activity
IFA22_RS20090	COG0442	prolyl-tRNA aminoacylation
IFA22_RS20095	COG4221	oxidoreductase activity
IFA22_RS20110	COG1024	Enoyl-CoA hydratase
IFA22_RS20130	COG4166	transmembrane transport
IFA22_RS20145	COG1872	DUF167
IFA22_RS20150	COG0762	integral membrane protein
IFA22_RS20155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IFA22_RS20160	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IFA22_RS20175	COG3022	response to hydroperoxide
IFA22_RS20180	COG0513	Belongs to the DEAD box helicase family
IFA22_RS20185	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IFA22_RS20210	COG0735	belongs to the Fur family
IFA22_RS20215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IFA22_RS20230	COG0776	regulation of translation
IFA22_RS20240	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IFA22_RS20265	COG0560	Phosphoserine phosphatase
IFA22_RS20275	COG3447	MASE1 domain protein
IFA22_RS20275	COG5001	Diguanylate cyclase
IFA22_RS20275	COG5002	protein histidine kinase activity
IFA22_RS20280	COG0813	purine-nucleoside phosphorylase activity
IFA22_RS20285	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IFA22_RS20290	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IFA22_RS20295	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IFA22_RS20305	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IFA22_RS20310	COG0084	hydrolase, TatD family'
IFA22_RS20315	COG2165	general secretion pathway protein
IFA22_RS20325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IFA22_RS20330	COG0004	ammonium transporteR
IFA22_RS20345	COG0795	lipopolysaccharide-transporting ATPase activity
IFA22_RS20350	COG0795	lipopolysaccharide-transporting ATPase activity
IFA22_RS20355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IFA22_RS20360	COG2927	DNA polymerase III (CHI subunit)
IFA22_RS20365	COG0525	valine-tRNA ligase activity
IFA22_RS20370	COG1253	flavin adenine dinucleotide binding
IFA22_RS20375	COG0586	Pfam SNARE associated Golgi protein
IFA22_RS20380	COG1686	Belongs to the peptidase S11 family
IFA22_RS20415	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IFA22_RS20420	COG0527	aspartate kinase activity
IFA22_RS20425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IFA22_RS20435	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IFA22_RS20440	COG1546	Belongs to the CinA family
IFA22_RS20445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IFA22_RS20465	COG3068	Protein conserved in bacteria
IFA22_RS20475	COG0739	heme binding
IFA22_RS20495	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IFA22_RS20500	COG1121	(ABC) transporter
IFA22_RS20505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IFA22_RS20510	COG0583	DNA-binding transcription factor activity
IFA22_RS20515	COG0697	spore germination
IFA22_RS20520	COG1573	uracil-dna glycosylase
IFA22_RS20525	COG2962	Rard protein
IFA22_RS20535	COG2827	Endonuclease containing a URI domain
IFA22_RS20550	COG1842	Phage shock protein A
IFA22_RS20555	COG0204	Acyl-transferase
IFA22_RS20575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IFA22_RS20625	COG0583	DNA-binding transcription factor activity
IFA22_RS20655	COG1289	transmembrane transporter activity
IFA22_RS20660	COG1566	PFAM secretion protein HlyD family protein
IFA22_RS20675	COG1051	belongs to the nudix hydrolase family
IFA22_RS20680	COG3150	esterase
IFA22_RS20690	COG3151	Protein conserved in bacteria
IFA22_RS20695	COG0494	nUDIX hydrolase
IFA22_RS20700	COG1538	Outer membrane efflux protein
IFA22_RS20705	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IFA22_RS20705	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IFA22_RS20710	COG1560	Kdo2-lipid A biosynthetic process
IFA22_RS20725	COG1392	Phosphate transport regulator
IFA22_RS20730	COG0306	phosphate transporter
IFA22_RS20735	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IFA22_RS20765	COG0583	DNA-binding transcription factor activity
IFA22_RS20770	COG1380	Effector of murein hydrolase LrgA
IFA22_RS20775	COG1346	cytolysis
IFA22_RS20790	COG0617	tRNA 3'-terminal CCA addition
IFA22_RS20795	COG3267	Type II secretory pathway component ExeA
IFA22_RS20795	COG3409	Peptidoglycan-binding domain 1 protein
IFA22_RS20805	COG1194	a g-specific adenine glycosylase
IFA22_RS20810	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IFA22_RS20820	COG3111	PFAM Bacterial OB fold (BOF) protein
IFA22_RS20825	COG3240	lipase activity
IFA22_RS20840	COG3009	Protein conserved in bacteria
IFA22_RS20845	COG3008	intermembrane lipid transfer
IFA22_RS20845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IFA22_RS20850	COG2995	paraquat-inducible protein a
IFA22_RS20860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IFA22_RS20870	COG4251	negative regulation of phosphorylation
IFA22_RS20870	COG2203	Gaf domain
IFA22_RS20870	COG5001	Diguanylate cyclase
IFA22_RS20870	COG3706	GGDEF domain
IFA22_RS20875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IFA22_RS20880	COG2813	Specifically methylates the guanine in position
IFA22_RS20885	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IFA22_RS20890	COG0297	glycogen (starch) synthase activity
IFA22_RS20930	COG1757	Na H antiporter
IFA22_RS20935	COG0583	DNA-binding transcription factor activity
IFA22_RS20940	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IFA22_RS20945	COG3842	ATPase activity
IFA22_RS20950	COG1176	ABC-type spermidine putrescine transport system, permease component I
IFA22_RS20955	COG1177	transmembrane transport
IFA22_RS20960	COG1012	belongs to the aldehyde dehydrogenase family
IFA22_RS20970	COG5006	permease, DMT superfamily
IFA22_RS20975	COG1522	sequence-specific DNA binding
IFA22_RS20980	COG0110	maltose O-acetyltransferase activity
IFA22_RS20985	COG0366	Alpha amylase catalytic
IFA22_RS20990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IFA22_RS20990	COG1263	PTS System
IFA22_RS21010	COG0252	asparaginase activity
IFA22_RS21025	COG1803	Methylglyoxal synthase
IFA22_RS21050	COG1444	tRNA N-acetyltransferase activity
IFA22_RS21060	COG0784	Response regulator, receiver
IFA22_RS21060	COG0835	chemotaxis
IFA22_RS21065	COG3314	Sporulation integral membrane protein YlbJ
IFA22_RS21105	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IFA22_RS21110	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IFA22_RS21125	COG0477	Major facilitator Superfamily
IFA22_RS21130	COG0523	cobalamin synthesis protein
IFA22_RS21140	COG1280	lysine exporter protein (LysE YggA)
IFA22_RS21150	COG2200	EAL domain
IFA22_RS21155	COG1049	propionate catabolic process, 2-methylcitrate cycle
IFA22_RS21160	COG1752	Esterase of the alpha-beta hydrolase superfamily
IFA22_RS21165	COG0840	transmembrane signaling receptor activity
IFA22_RS21180	COG5001	Diguanylate cyclase
IFA22_RS21180	COG5002	protein histidine kinase activity
IFA22_RS21180	COG3447	MASE1 domain protein
IFA22_RS21185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IFA22_RS21190	COG0508	dehydrogenase complex catalyzes the overall conversion of
IFA22_RS21195	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IFA22_RS21200	COG2186	Transcriptional regulator
IFA22_RS21225	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IFA22_RS21230	COG1459	type II secretion system
IFA22_RS21245	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
IFA22_RS21250	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IFA22_RS21255	COG0494	nUDIX hydrolase
IFA22_RS21265	COG0653	protein targeting
IFA22_RS21275	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IFA22_RS21280	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IFA22_RS21285	COG0849	cell division
IFA22_RS21290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IFA22_RS21295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IFA22_RS21300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IFA22_RS21305	COG0772	Belongs to the SEDS family
IFA22_RS21310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IFA22_RS21315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IFA22_RS21320	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IFA22_RS21330	COG0768	penicillin binding
IFA22_RS21335	COG3116	cell division
IFA22_RS21340	COG0275	rRNA processing
IFA22_RS21345	COG2001	Belongs to the MraZ family
IFA22_RS21355	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IFA22_RS21360	COG3107	peptidoglycan biosynthetic process
IFA22_RS21365	COG0792	nuclease activity
IFA22_RS21370	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IFA22_RS21375	COG2823	Periplasmic or secreted lipoprotein
IFA22_RS21380	COG2969	positive regulation of protein catabolic process
IFA22_RS21385	COG0625	glutathione transferase activity
IFA22_RS21390	COG2857	Cytochrome c1
IFA22_RS21395	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IFA22_RS21400	COG0723	plastoquinol--plastocyanin reductase activity
IFA22_RS21405	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IFA22_RS21410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IFA22_RS21415	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IFA22_RS21425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IFA22_RS21430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IFA22_RS21460	COG3964	amidohydrolase
IFA22_RS21475	COG3711	transcriptional antiterminator
IFA22_RS21475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IFA22_RS21480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IFA22_RS21485	COG1660	Displays ATPase and GTPase activities
IFA22_RS21490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IFA22_RS21500	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IFA22_RS21505	COG1137	ATPase activity
IFA22_RS21510	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IFA22_RS21515	COG3117	lipopolysaccharide transmembrane transporter activity
IFA22_RS21520	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IFA22_RS21525	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IFA22_RS21525	COG0517	IMP dehydrogenase activity
IFA22_RS21530	COG1127	ABC transporter
IFA22_RS21535	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IFA22_RS21540	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IFA22_RS21545	COG2854	intermembrane phospholipid transfer
IFA22_RS21555	COG5007	Belongs to the BolA IbaG family
IFA22_RS21560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IFA22_RS21565	COG0312	modulator of DNA gyrase
IFA22_RS21595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IFA22_RS21615	COG3645	SOS response
IFA22_RS21615	COG3646	Phage regulatory protein
IFA22_RS21660	COG3028	Belongs to the UPF0307 family
IFA22_RS21670	COG2926	Belongs to the UPF0265 family
IFA22_RS21700	COG1396	sequence-specific DNA binding
IFA22_RS21705	COG3135	benzoate transporter
IFA22_RS21735	COG3047	cAMP biosynthetic process
IFA22_RS21745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IFA22_RS21750	COG2197	response regulator
IFA22_RS21755	COG0629	single-stranded DNA binding
IFA22_RS21775	COG1278	Cold shock
IFA22_RS21780	COG4771	TonB-dependent receptor
IFA22_RS21785	COG2203	Gaf domain
IFA22_RS21785	COG3706	GGDEF domain
IFA22_RS21785	COG5001	Diguanylate cyclase
IFA22_RS21785	COG4251	negative regulation of phosphorylation
IFA22_RS21835	COG0346	lactoylglutathione lyase activity
IFA22_RS21855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IFA22_RS21860	COG1074	ATP-dependent DNA helicase activity
IFA22_RS21865	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IFA22_RS21870	COG2259	Doxx family
IFA22_RS21875	COG1741	Belongs to the pirin family
IFA22_RS21885	COG0583	DNA-binding transcription factor activity
IFA22_RS21910	COG1175	transmembrane transport
IFA22_RS21920	COG3842	ATPase activity
IFA22_RS21930	COG2199	diguanylate cyclase activity
IFA22_RS21930	COG2203	Gaf domain
IFA22_RS21950	COG1247	-acetyltransferase
IFA22_RS21955	COG0753	catalase activity
IFA22_RS21980	COG0494	nUDIX hydrolase
IFA22_RS21985	COG0628	permease
IFA22_RS22005	COG2957	Belongs to the agmatine deiminase family
IFA22_RS22010	COG0583	DNA-binding transcription factor activity
IFA22_RS22015	COG3284	Transcriptional regulator
IFA22_RS22025	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
IFA22_RS22025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IFA22_RS22025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IFA22_RS22030	COG1461	Dihydroxyacetone kinase
IFA22_RS22035	COG2376	Dihydroxyacetone kinase
IFA22_RS22040	COG2252	PERMEase
IFA22_RS22075	COG0203	ribosomal protein L17
IFA22_RS22080	COG0202	RNA polymerase activity
IFA22_RS22085	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IFA22_RS22090	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IFA22_RS22095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IFA22_RS22100	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IFA22_RS22105	COG0201	protein transport
IFA22_RS22110	COG0200	Binds to the 23S rRNA
IFA22_RS22115	COG1841	ribosomal large subunit assembly
IFA22_RS22120	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IFA22_RS22125	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IFA22_RS22130	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IFA22_RS22135	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IFA22_RS22140	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IFA22_RS22145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IFA22_RS22150	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IFA22_RS22155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IFA22_RS22160	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IFA22_RS22165	COG0255	Belongs to the universal ribosomal protein uL29 family
IFA22_RS22170	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IFA22_RS22175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IFA22_RS22180	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IFA22_RS22185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IFA22_RS22190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IFA22_RS22195	COG0089	rRNA binding
IFA22_RS22200	COG0088	Forms part of the polypeptide exit tunnel
IFA22_RS22205	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IFA22_RS22210	COG0051	transcription antitermination factor activity, RNA binding
IFA22_RS22230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IFA22_RS22235	COG2183	response to ionizing radiation
IFA22_RS22255	COG0596	Alpha beta hydrolase
IFA22_RS22265	COG1040	competence protein
IFA22_RS22270	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IFA22_RS22270	COG0316	Belongs to the HesB IscA family
IFA22_RS22275	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IFA22_RS22280	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IFA22_RS22285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IFA22_RS22290	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IFA22_RS22295	COG4942	peptidase
IFA22_RS22305	COG1609	Transcriptional regulator
IFA22_RS22310	COG0800	Aldolase
IFA22_RS22315	COG0129	dihydroxy-acid dehydratase activity
IFA22_RS22320	COG3265	gluconokinase activity
IFA22_RS22325	COG2610	gluconate transmembrane transporter activity
IFA22_RS22330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IFA22_RS22335	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IFA22_RS22345	COG0456	acetyltransferase
IFA22_RS22355	COG1490	D-aminoacyl-tRNA deacylase activity
IFA22_RS22360	COG1295	ribonuclease BN
IFA22_RS22365	COG1217	gtp-binding protein TYPA
IFA22_RS22370	COG0174	glutamine synthetase
IFA22_RS22380	COG3852	Histidine kinase
IFA22_RS22385	COG2204	response regulator
IFA22_RS22390	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IFA22_RS22395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IFA22_RS22405	COG3078	GTPase activator activity
IFA22_RS22415	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IFA22_RS22425	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IFA22_RS22430	COG0408	coproporphyrinogen oxidase activity
IFA22_RS22435	COG0009	L-threonylcarbamoyladenylate synthase
IFA22_RS22445	COG0551	DNA topoisomerase type I activity
IFA22_RS22450	COG2922	Belongs to the Smg family
IFA22_RS22455	COG0758	DNA mediated transformation
IFA22_RS22465	COG0242	peptide deformylase activity
IFA22_RS22470	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IFA22_RS22475	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IFA22_RS22475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IFA22_RS22480	COG0569	domain protein
IFA22_RS22485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IFA22_RS22490	COG1322	Protein conserved in bacteria
IFA22_RS22510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IFA22_RS22515	COG0686	Belongs to the AlaDH PNT family
IFA22_RS22520	COG0519	Catalyzes the synthesis of GMP from XMP
IFA22_RS22520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IFA22_RS22530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IFA22_RS22535	COG1396	sequence-specific DNA binding
IFA22_RS22540	COG1012	belongs to the aldehyde dehydrogenase family
IFA22_RS22550	COG2962	Rard protein
IFA22_RS22560	COG1280	lysine exporter protein (LysE YggA)
IFA22_RS22570	COG2391	methyltransferase activity
IFA22_RS22645	COG0210	DNA helicase
IFA22_RS22650	COG1744	ABC transporter substrate-binding protein PnrA-like
IFA22_RS22655	COG3845	ABC transporter
IFA22_RS22660	COG4603	Belongs to the binding-protein-dependent transport system permease family
IFA22_RS22665	COG1079	Belongs to the binding-protein-dependent transport system permease family
IFA22_RS22670	COG0583	DNA-binding transcription factor activity
IFA22_RS22690	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IFA22_RS22695	COG0385	Bile acid
IFA22_RS22700	COG0531	amino acid
IFA22_RS22705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IFA22_RS22710	COG0531	amino acid
IFA22_RS22715	COG2731	YhcH YjgK YiaL family protein
IFA22_RS22720	COG3250	beta-galactosidase activity
IFA22_RS22725	COG1609	Transcriptional regulator
IFA22_RS22760	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IFA22_RS22765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IFA22_RS22765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IFA22_RS22770	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IFA22_RS22775	COG3074	FtsZ-dependent cytokinesis
IFA22_RS22785	COG1045	serine acetyltransferase
IFA22_RS22795	COG0745	RESPONSE REGULATOR receiver
IFA22_RS22800	COG2205	protein histidine kinase activity
IFA22_RS22805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IFA22_RS22810	COG0534	Mate efflux family protein
IFA22_RS22825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IFA22_RS22830	COG2937	Belongs to the GPAT DAPAT family
IFA22_RS22835	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IFA22_RS22840	COG3161	chorismate lyase activity
IFA22_RS22845	COG1580	Controls the rotational direction of flagella during chemotaxis
IFA22_RS22860	COG0604	alcohol dehydrogenase
IFA22_RS22865	COG1609	Transcriptional regulator
IFA22_RS22885	COG1519	Transferase
IFA22_RS22890	COG0859	PFAM glycosyl transferase family 9
IFA22_RS22895	COG0463	Glycosyl transferase, family 2
IFA22_RS22900	COG0859	PFAM glycosyl transferase family 9
IFA22_RS22905	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IFA22_RS22910	COG2990	Protein conserved in bacteria
IFA22_RS22915	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IFA22_RS22925	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IFA22_RS22930	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IFA22_RS22935	COG2003	Belongs to the UPF0758 family
IFA22_RS22940	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IFA22_RS22945	COG0756	dUTP diphosphatase activity
IFA22_RS22950	COG1309	transcriptional regulator
IFA22_RS22955	COG0668	transmembrane transport
IFA22_RS22965	COG0166	Belongs to the GPI family
IFA22_RS22970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IFA22_RS22975	COG0583	DNA-binding transcription factor activity
IFA22_RS23020	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
IFA22_RS23025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IFA22_RS23030	COG1739	Uncharacterized protein family UPF0029
IFA22_RS23035	COG0006	proline dipeptidase activity
IFA22_RS23040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IFA22_RS23045	COG1250	3-hydroxyacyl-CoA dehydrogenase
IFA22_RS23045	COG1024	Enoyl-CoA hydratase
IFA22_RS23050	COG0183	Belongs to the thiolase family
IFA22_RS23075	COG0425	Belongs to the sulfur carrier protein TusA family
IFA22_RS23080	COG0251	oxidation-reduction process
IFA22_RS23090	COG2885	chlorophyll binding
IFA22_RS23095	COG1335	isochorismatase
IFA22_RS23100	COG2818	Glycosylase
IFA22_RS23105	COG0752	glycyl-tRNA synthetase alpha subunit
IFA22_RS23110	COG0751	glycine-tRNA ligase activity
IFA22_RS23120	COG2046	Belongs to the sulfate adenylyltransferase family
IFA22_RS23120	COG0529	Catalyzes the synthesis of activated sulfate
IFA22_RS23140	COG0814	amino acid
IFA22_RS23145	COG0348	domain, Protein
IFA22_RS23155	COG0446	pyridine nucleotide-disulphide oxidoreductase
IFA22_RS23160	COG1773	rubredoxin
IFA22_RS23160	COG0426	domain, Protein
IFA22_RS23170	COG2188	Transcriptional regulator
IFA22_RS23185	COG1609	Transcriptional regulator
IFA22_RS23225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IFA22_RS23250	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IFA22_RS23265	COG3118	belongs to the thioredoxin family
IFA22_RS23270	COG0513	Belongs to the DEAD box helicase family
IFA22_RS23275	COG0248	Ppx GppA phosphatase
IFA22_RS23290	COG0742	ribosomal rna small subunit methyltransferase
IFA22_RS23310	COG0084	hydrolase, TatD family'
IFA22_RS23315	COG0805	protein transport
IFA22_RS23320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IFA22_RS23330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IFA22_RS23335	COG3165	ubiquinone biosynthetic process from chorismate
IFA22_RS23345	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IFA22_RS23350	COG0402	S-adenosylhomocysteine deaminase activity
IFA22_RS23395	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IFA22_RS23400	COG0848	biopolymer transport protein
IFA22_RS23405	COG0811	peptide transport
IFA22_RS23410	COG0811	peptide transport
IFA22_RS23420	COG2771	luxR family
IFA22_RS23425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IFA22_RS23430	COG1349	DNA-binding transcription factor activity
IFA22_RS23435	COG0745	RESPONSE REGULATOR receiver
IFA22_RS23440	COG2205	protein histidine kinase activity
IFA22_RS23450	COG4452	Inner membrane protein CreD
IFA22_RS23465	COG0438	transferase activity, transferring glycosyl groups
IFA22_RS23465	COG0297	glycogen (starch) synthase activity
IFA22_RS23470	COG1045	serine acetyltransferase
IFA22_RS23475	COG0438	transferase activity, transferring glycosyl groups
IFA22_RS23510	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IFA22_RS23515	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IFA22_RS23520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IFA22_RS23525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IFA22_RS23530	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IFA22_RS23535	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IFA22_RS23540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IFA22_RS23545	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IFA22_RS23555	COG0356	it plays a direct role in the translocation of protons across the membrane
IFA22_RS23565	COG1475	DNA binding
IFA22_RS23570	COG1192	Involved in chromosome partitioning
IFA22_RS23575	COG0357	Ribosomal RNA small subunit methyltransferase G
IFA22_RS23580	COG0445	tRNA wobble uridine modification
IFA22_RS23585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IFA22_RS23590	COG4774	siderophore transport
IFA22_RS23595	COG4615	Cyclic peptide transporter
IFA22_RS23600	COG1120	ATPase activity
IFA22_RS23610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IFA22_RS23615	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IFA22_RS23620	COG0706	membrane insertase activity
IFA22_RS23625	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IFA22_RS23630	COG0594	ribonuclease P activity
IFA22_RS23635	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IFA22_RS23640	COG1126	abc transporter atp-binding protein
IFA22_RS23675	COG0789	Transcriptional regulator
IFA22_RS23695	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IFA22_RS23720	COG4962	Type ii secretion system protein e
IFA22_RS23725	COG3838	Conjugal transfer protein Trbc
IFA22_RS23730	COG5268	conjugation
IFA22_RS23735	COG3451	type IV secretory pathway VirB4
IFA22_RS23805	COG0840	transmembrane signaling receptor activity
IFA22_RS23845	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IFA22_RS23880	COG0419	ATPase involved in DNA repair
IFA22_RS23905	COG3550	peptidyl-serine autophosphorylation
IFA22_RS23985	COG0776	regulation of translation
IFA22_RS24005	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IFA22_RS24105	COG0358	DNA primase activity
IFA22_RS24120	COG1923	regulation of RNA biosynthetic process
IFA22_RS24150	COG5301	cellulose 1,4-beta-cellobiosidase activity
IFA22_RS24280	COG1136	(ABC) transporter
IFA22_RS24300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IFA22_RS24335	COG4974	Belongs to the 'phage' integrase family
IFA22_RS24420	COG1192	Involved in chromosome partitioning
IFA22_RS24470	COG2003	Belongs to the UPF0758 family
IFA22_RS24505	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IFA22_RS24540	COG4227	nucleotidyltransferase activity
IFA22_RS24710	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IFA22_RS24870	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IFA22_RS24890	COG0789	Transcriptional regulator
IFA22_RS25005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IFA22_RS25080	COG0840	transmembrane signaling receptor activity
IFA22_RS25150	COG3451	type IV secretory pathway VirB4
IFA22_RS25155	COG5268	conjugation
IFA22_RS25160	COG3838	Conjugal transfer protein Trbc
IFA22_RS25165	COG4962	Type ii secretion system protein e
IFA22_RS25185	COG0840	transmembrane signaling receptor activity
IFA22_RS25195	COG4644	lycopene metabolic process
IFA22_RS25270	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IFA22_RS25295	COG1879	ABC-type sugar transport system periplasmic component
IFA22_RS25305	COG3041	Addiction module toxin RelE StbE family
IFA22_RS25310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IFA22_RS25425	COG1192	Involved in chromosome partitioning
IFA22_RS25515	COG2026	Addiction module toxin, RelE StbE family
IFA22_RS25520	COG3077	Addiction module antitoxin, RelB DinJ family
IFA22_RS25525	COG1192	Involved in chromosome partitioning