locus-tag	class	description
C7K70_RS00010	COG0752	glycyl-tRNA synthetase alpha subunit
C7K70_RS00015	COG2818	Glycosylase
C7K70_RS00020	COG1335	isochorismatase
C7K70_RS00025	COG2885	chlorophyll binding
C7K70_RS00030	COG0251	oxidation-reduction process
C7K70_RS00035	COG0425	Belongs to the sulfur carrier protein TusA family
C7K70_RS00060	COG0183	Belongs to the thiolase family
C7K70_RS00065	COG1250	3-hydroxyacyl-CoA dehydrogenase
C7K70_RS00065	COG1024	Enoyl-CoA hydratase
C7K70_RS00070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C7K70_RS00075	COG0006	proline dipeptidase activity
C7K70_RS00080	COG1739	Uncharacterized protein family UPF0029
C7K70_RS00085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C7K70_RS00090	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C7K70_RS00120	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C7K70_RS00125	COG2166	iron-sulfur cluster assembly
C7K70_RS00130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C7K70_RS00135	COG0210	DNA helicase
C7K70_RS00145	COG3245	cytochrome
C7K70_RS00150	COG1063	alcohol dehydrogenase
C7K70_RS00155	COG0156	8-amino-7-oxononanoate synthase activity
C7K70_RS00165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7K70_RS00180	COG3306	glycosyltransferase involved in LPS biosynthesis
C7K70_RS00200	COG1561	YicC-like family, N-terminal region
C7K70_RS00205	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C7K70_RS00210	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C7K70_RS00220	COG0789	Transcriptional regulator
C7K70_RS00225	COG5001	Diguanylate cyclase
C7K70_RS00225	COG2203	Gaf domain
C7K70_RS00225	COG4251	negative regulation of phosphorylation
C7K70_RS00225	COG3706	GGDEF domain
C7K70_RS00230	COG3084	Protein conserved in bacteria
C7K70_RS00240	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C7K70_RS00245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C7K70_RS00250	COG3639	organic phosphonate transmembrane transporter activity
C7K70_RS00255	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C7K70_RS00260	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C7K70_RS00270	COG1335	isochorismatase
C7K70_RS00280	COG1683	Conserved Protein
C7K70_RS00285	COG0204	Acyl-transferase
C7K70_RS00290	COG0204	Acyl-transferase
C7K70_RS00295	COG0606	chelatase, subunit chli
C7K70_RS00310	COG3978	acetolactate synthase activity
C7K70_RS00320	COG0129	dihydroxy-acid dehydratase activity
C7K70_RS00340	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C7K70_RS00345	COG0254	rRNA binding
C7K70_RS00350	COG0702	epimerase
C7K70_RS00355	COG0281	malic enzyme
C7K70_RS00365	COG2205	protein histidine kinase activity
C7K70_RS00370	COG0745	RESPONSE REGULATOR receiver
C7K70_RS00375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C7K70_RS00410	COG4310	Domain of unknown function (DUF2172)
C7K70_RS00430	COG2089	acid synthase
C7K70_RS00440	COG1083	cytidylyl-transferase
C7K70_RS00455	COG1028	Short-chain dehydrogenase reductase Sdr
C7K70_RS00460	COG0318	PFAM AMP-dependent synthetase and ligase
C7K70_RS00475	COG1215	transferase activity, transferring glycosyl groups
C7K70_RS00500	COG1216	Glycosyl transferase, family 2
C7K70_RS00510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7K70_RS00525	COG2089	acid synthase
C7K70_RS00530	COG1083	cytidylyl-transferase
C7K70_RS00550	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C7K70_RS00555	COG1086	Polysaccharide biosynthesis protein
C7K70_RS00560	COG0366	Alpha amylase catalytic
C7K70_RS00575	COG0443	Heat shock 70 kDa protein
C7K70_RS00580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7K70_RS00585	COG3045	CreA protein
C7K70_RS00605	COG0174	glutamine synthetase
C7K70_RS00625	COG3842	ATPase activity
C7K70_RS00630	COG1176	ABC-type spermidine putrescine transport system, permease component I
C7K70_RS00635	COG1177	transmembrane transport
C7K70_RS00640	COG2258	MOSC domain
C7K70_RS00660	COG2050	protein possibly involved in aromatic compounds catabolism
C7K70_RS00665	COG0514	ATP-dependent DNA helicase (RecQ)
C7K70_RS00675	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C7K70_RS00685	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C7K70_RS00690	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C7K70_RS00700	COG2239	Acts as a magnesium transporter
C7K70_RS00705	COG1648	precorrin-2 dehydrogenase activity
C7K70_RS00705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C7K70_RS00710	COG2116	formate transmembrane transporter activity
C7K70_RS00720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C7K70_RS00730	COG0477	Major facilitator Superfamily
C7K70_RS00735	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C7K70_RS00740	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C7K70_RS00760	COG1595	DNA-templated transcription, initiation
C7K70_RS00765	COG3806	Anti-sigma factor
C7K70_RS00770	COG1968	undecaprenyl-diphosphatase activity
C7K70_RS00775	COG0667	Aldo Keto reductase
C7K70_RS00780	COG2017	converts alpha-aldose to the beta-anomer
C7K70_RS00785	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C7K70_RS00795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C7K70_RS00800	COG1609	Transcriptional regulator
C7K70_RS00805	COG3250	beta-galactosidase activity
C7K70_RS00825	COG0840	transmembrane signaling receptor activity
C7K70_RS00855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C7K70_RS00860	COG1288	antiporter activity
C7K70_RS00865	COG1438	arginine binding
C7K70_RS00870	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
C7K70_RS00875	COG0540	Belongs to the ATCase OTCase family
C7K70_RS00890	COG0688	phosphatidylethanolamine metabolic process
C7K70_RS00905	COG0583	DNA-binding transcription factor activity
C7K70_RS00915	COG3040	lipid binding
C7K70_RS00920	COG2207	Transcriptional regulator
C7K70_RS00925	COG1979	alcohol dehydrogenase
C7K70_RS00930	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C7K70_RS00935	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C7K70_RS00945	COG3681	Belongs to the UPF0597 family
C7K70_RS00955	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7K70_RS00960	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C7K70_RS00965	COG0564	pseudouridine synthase activity
C7K70_RS00975	COG0542	response to heat
C7K70_RS00980	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C7K70_RS00990	COG2502	aspartate--ammonia ligase
C7K70_RS00995	COG1522	sequence-specific DNA binding
C7K70_RS01005	COG5413	integral membrane protein
C7K70_RS01030	COG2205	protein histidine kinase activity
C7K70_RS01040	COG2204	response regulator
C7K70_RS01060	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C7K70_RS01090	COG0243	molybdopterin cofactor binding
C7K70_RS01095	COG3005	denitrification pathway
C7K70_RS01100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C7K70_RS01120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C7K70_RS01125	COG0569	domain protein
C7K70_RS01130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C7K70_RS01155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C7K70_RS01170	COG0250	Participates in transcription elongation, termination and antitermination
C7K70_RS01175	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C7K70_RS01180	COG0081	regulation of translation
C7K70_RS01185	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C7K70_RS01190	COG0222	ribosome binding
C7K70_RS01195	COG0085	RNA polymerase activity
C7K70_RS01200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C7K70_RS01205	COG2964	Protein conserved in bacteria
C7K70_RS01210	COG0251	oxidation-reduction process
C7K70_RS01220	COG2923	Belongs to the DsrF TusC family
C7K70_RS01225	COG2168	tRNA wobble position uridine thiolation
C7K70_RS01230	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C7K70_RS01235	COG0049	tRNA binding
C7K70_RS01240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C7K70_RS01245	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C7K70_RS01250	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C7K70_RS01290	COG2252	PERMEase
C7K70_RS01295	COG2376	Dihydroxyacetone kinase
C7K70_RS01300	COG1461	Dihydroxyacetone kinase
C7K70_RS01315	COG3284	Transcriptional regulator
C7K70_RS01320	COG0583	DNA-binding transcription factor activity
C7K70_RS01325	COG2957	Belongs to the agmatine deiminase family
C7K70_RS01335	COG0628	permease
C7K70_RS01340	COG0494	nUDIX hydrolase
C7K70_RS01365	COG0753	catalase activity
C7K70_RS01370	COG1247	-acetyltransferase
C7K70_RS01390	COG2203	Gaf domain
C7K70_RS01390	COG2199	diguanylate cyclase activity
C7K70_RS01400	COG3842	ATPase activity
C7K70_RS01410	COG1176	ABC-type spermidine putrescine transport system, permease component I
C7K70_RS01435	COG0583	DNA-binding transcription factor activity
C7K70_RS01445	COG1741	Belongs to the pirin family
C7K70_RS01450	COG2259	Doxx family
C7K70_RS01455	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C7K70_RS01460	COG1074	ATP-dependent DNA helicase activity
C7K70_RS01465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C7K70_RS01475	COG0346	lactoylglutathione lyase activity
C7K70_RS01525	COG4251	negative regulation of phosphorylation
C7K70_RS01525	COG3706	GGDEF domain
C7K70_RS01525	COG2203	Gaf domain
C7K70_RS01525	COG5001	Diguanylate cyclase
C7K70_RS01530	COG4771	TonB-dependent receptor
C7K70_RS01540	COG1278	Cold shock
C7K70_RS01565	COG0629	single-stranded DNA binding
C7K70_RS01570	COG2197	response regulator
C7K70_RS01575	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7K70_RS01585	COG3047	cAMP biosynthetic process
C7K70_RS01590	COG0840	transmembrane signaling receptor activity
C7K70_RS01615	COG3135	benzoate transporter
C7K70_RS01620	COG1396	sequence-specific DNA binding
C7K70_RS01650	COG2926	Belongs to the UPF0265 family
C7K70_RS01660	COG3028	Belongs to the UPF0307 family
C7K70_RS01665	COG0312	modulator of DNA gyrase
C7K70_RS01670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C7K70_RS01675	COG5007	Belongs to the BolA IbaG family
C7K70_RS01685	COG2854	intermembrane phospholipid transfer
C7K70_RS01690	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C7K70_RS01695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C7K70_RS01700	COG1127	ABC transporter
C7K70_RS01705	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C7K70_RS01705	COG0517	IMP dehydrogenase activity
C7K70_RS01710	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C7K70_RS01715	COG3117	lipopolysaccharide transmembrane transporter activity
C7K70_RS01720	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C7K70_RS01725	COG1137	ATPase activity
C7K70_RS01730	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C7K70_RS01740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K70_RS01745	COG1660	Displays ATPase and GTPase activities
C7K70_RS01750	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K70_RS01755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K70_RS01755	COG3711	transcriptional antiterminator
C7K70_RS01770	COG3964	amidohydrolase
C7K70_RS01800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7K70_RS01805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7K70_RS01815	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C7K70_RS01820	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C7K70_RS01825	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C7K70_RS01830	COG0723	plastoquinol--plastocyanin reductase activity
C7K70_RS01835	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C7K70_RS01840	COG2857	Cytochrome c1
C7K70_RS01845	COG0625	glutathione transferase activity
C7K70_RS01850	COG2969	positive regulation of protein catabolic process
C7K70_RS01855	COG2823	Periplasmic or secreted lipoprotein
C7K70_RS01860	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C7K70_RS01865	COG0792	nuclease activity
C7K70_RS01870	COG3107	peptidoglycan biosynthetic process
C7K70_RS01875	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C7K70_RS01925	COG1677	Flagellar hook-basal body complex protein FliE
C7K70_RS01935	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C7K70_RS01970	COG1815	bacterial-type flagellum-dependent cell motility
C7K70_RS01985	COG1749	Flagellar hook protein flgE
C7K70_RS01995	COG4786	Flagellar basal body rod
C7K70_RS02000	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C7K70_RS02005	COG1706	bacterial-type flagellum-dependent cell motility
C7K70_RS02015	COG1256	bacterial-type flagellum assembly
C7K70_RS02015	COG4786	Flagellar basal body rod
C7K70_RS02020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C7K70_RS02035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C7K70_RS02040	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C7K70_RS02065	COG1191	sigma factor activity
C7K70_RS02070	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C7K70_RS02075	COG1360	Flagellar Motor Protein
C7K70_RS02085	COG0741	lytic transglycosylase activity
C7K70_RS02085	COG1388	LysM domain
C7K70_RS02095	COG2001	Belongs to the MraZ family
C7K70_RS02100	COG0275	rRNA processing
C7K70_RS02105	COG3116	cell division
C7K70_RS02110	COG0768	penicillin binding
C7K70_RS02120	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C7K70_RS02125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C7K70_RS02130	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C7K70_RS02135	COG0772	Belongs to the SEDS family
C7K70_RS02140	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C7K70_RS02145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C7K70_RS02150	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C7K70_RS02155	COG0849	cell division
C7K70_RS02160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C7K70_RS02165	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C7K70_RS02175	COG0653	protein targeting
C7K70_RS02185	COG0494	nUDIX hydrolase
C7K70_RS02195	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C7K70_RS02200	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C7K70_RS02215	COG1459	type II secretion system
C7K70_RS02220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7K70_RS02250	COG2186	Transcriptional regulator
C7K70_RS02255	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C7K70_RS02260	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7K70_RS02265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7K70_RS02270	COG5001	Diguanylate cyclase
C7K70_RS02270	COG3447	MASE1 domain protein
C7K70_RS02270	COG5002	protein histidine kinase activity
C7K70_RS02280	COG0840	transmembrane signaling receptor activity
C7K70_RS02285	COG0840	transmembrane signaling receptor activity
C7K70_RS02290	COG1752	Esterase of the alpha-beta hydrolase superfamily
C7K70_RS02295	COG1049	propionate catabolic process, 2-methylcitrate cycle
C7K70_RS02305	COG1280	lysine exporter protein (LysE YggA)
C7K70_RS02315	COG0523	cobalamin synthesis protein
C7K70_RS02320	COG0477	Major facilitator Superfamily
C7K70_RS02335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C7K70_RS02340	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C7K70_RS02425	COG3314	Sporulation integral membrane protein YlbJ
C7K70_RS02430	COG0784	Response regulator, receiver
C7K70_RS02430	COG0835	chemotaxis
C7K70_RS02435	COG1028	Short-chain dehydrogenase reductase Sdr
C7K70_RS02440	COG1444	tRNA N-acetyltransferase activity
C7K70_RS02465	COG1803	Methylglyoxal synthase
C7K70_RS02480	COG0252	asparaginase activity
C7K70_RS02500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K70_RS02500	COG1263	PTS System
C7K70_RS02505	COG0366	Alpha amylase catalytic
C7K70_RS02510	COG0110	maltose O-acetyltransferase activity
C7K70_RS02515	COG1522	sequence-specific DNA binding
C7K70_RS02520	COG5006	permease, DMT superfamily
C7K70_RS02530	COG1012	belongs to the aldehyde dehydrogenase family
C7K70_RS02535	COG1177	transmembrane transport
C7K70_RS02540	COG1176	ABC-type spermidine putrescine transport system, permease component I
C7K70_RS02545	COG3842	ATPase activity
C7K70_RS02550	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C7K70_RS02555	COG0583	DNA-binding transcription factor activity
C7K70_RS02560	COG1757	Na H antiporter
C7K70_RS02600	COG0297	glycogen (starch) synthase activity
C7K70_RS02605	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C7K70_RS02610	COG2813	Specifically methylates the guanine in position
C7K70_RS02615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C7K70_RS02620	COG2203	Gaf domain
C7K70_RS02620	COG3706	GGDEF domain
C7K70_RS02620	COG5001	Diguanylate cyclase
C7K70_RS02620	COG4251	negative regulation of phosphorylation
C7K70_RS02630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K70_RS02640	COG2995	paraquat-inducible protein a
C7K70_RS02645	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C7K70_RS02645	COG3008	intermembrane lipid transfer
C7K70_RS02650	COG3009	Protein conserved in bacteria
C7K70_RS02655	COG2885	chlorophyll binding
C7K70_RS02655	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C7K70_RS02665	COG3240	lipase activity
C7K70_RS02670	COG3111	PFAM Bacterial OB fold (BOF) protein
C7K70_RS02680	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C7K70_RS02685	COG1194	a g-specific adenine glycosylase
C7K70_RS02695	COG3409	Peptidoglycan-binding domain 1 protein
C7K70_RS02695	COG3267	Type II secretory pathway component ExeA
C7K70_RS02700	COG0617	tRNA 3'-terminal CCA addition
C7K70_RS02715	COG1346	cytolysis
C7K70_RS02720	COG1380	Effector of murein hydrolase LrgA
C7K70_RS02725	COG0583	DNA-binding transcription factor activity
C7K70_RS02755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C7K70_RS02760	COG0306	phosphate transporter
C7K70_RS02765	COG1392	Phosphate transport regulator
C7K70_RS02780	COG1560	Kdo2-lipid A biosynthetic process
C7K70_RS02785	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C7K70_RS02785	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C7K70_RS02790	COG1538	Outer membrane efflux protein
C7K70_RS02795	COG0494	nUDIX hydrolase
C7K70_RS02800	COG3151	Protein conserved in bacteria
C7K70_RS02810	COG3150	esterase
C7K70_RS02815	COG1051	belongs to the nudix hydrolase family
C7K70_RS02830	COG1566	PFAM secretion protein HlyD family protein
C7K70_RS02835	COG1289	transmembrane transporter activity
C7K70_RS02905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7K70_RS02930	COG0204	Acyl-transferase
C7K70_RS02935	COG1842	Phage shock protein A
C7K70_RS02950	COG2827	Endonuclease containing a URI domain
C7K70_RS02965	COG1573	uracil-dna glycosylase
C7K70_RS02970	COG0697	spore germination
C7K70_RS02975	COG0583	DNA-binding transcription factor activity
C7K70_RS02980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C7K70_RS02985	COG1121	(ABC) transporter
C7K70_RS02990	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C7K70_RS03010	COG0739	heme binding
C7K70_RS03020	COG3068	Protein conserved in bacteria
C7K70_RS03040	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C7K70_RS03045	COG1546	Belongs to the CinA family
C7K70_RS03050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C7K70_RS03060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C7K70_RS03065	COG0527	aspartate kinase activity
C7K70_RS03070	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C7K70_RS03105	COG1686	Belongs to the peptidase S11 family
C7K70_RS03110	COG0586	Pfam SNARE associated Golgi protein
C7K70_RS03115	COG1253	flavin adenine dinucleotide binding
C7K70_RS03120	COG0525	valine-tRNA ligase activity
C7K70_RS03125	COG2927	DNA polymerase III (CHI subunit)
C7K70_RS03130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C7K70_RS03135	COG0795	lipopolysaccharide-transporting ATPase activity
C7K70_RS03140	COG0795	lipopolysaccharide-transporting ATPase activity
C7K70_RS03155	COG0582	viral genome integration into host DNA
C7K70_RS03210	COG0004	ammonium transporteR
C7K70_RS03215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C7K70_RS03225	COG2165	general secretion pathway protein
C7K70_RS03230	COG0084	hydrolase, TatD family'
C7K70_RS03235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C7K70_RS03245	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7K70_RS03250	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C7K70_RS03255	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C7K70_RS03260	COG0813	purine-nucleoside phosphorylase activity
C7K70_RS03265	COG5001	Diguanylate cyclase
C7K70_RS03265	COG5002	protein histidine kinase activity
C7K70_RS03265	COG3447	MASE1 domain protein
C7K70_RS03275	COG0560	Phosphoserine phosphatase
C7K70_RS03300	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C7K70_RS03305	COG0776	regulation of translation
C7K70_RS03320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C7K70_RS03325	COG0735	belongs to the Fur family
C7K70_RS03350	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C7K70_RS03355	COG0513	Belongs to the DEAD box helicase family
C7K70_RS03360	COG3022	response to hydroperoxide
C7K70_RS03375	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C7K70_RS03380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C7K70_RS03385	COG0762	integral membrane protein
C7K70_RS03390	COG1872	DUF167
C7K70_RS03405	COG4166	transmembrane transport
C7K70_RS03425	COG1024	Enoyl-CoA hydratase
C7K70_RS03440	COG4221	oxidoreductase activity
C7K70_RS03445	COG0442	prolyl-tRNA aminoacylation
C7K70_RS03450	COG0840	transmembrane signaling receptor activity
C7K70_RS03455	COG0632	four-way junction helicase activity
C7K70_RS03460	COG2255	four-way junction helicase activity
C7K70_RS03465	COG1271	oxidase subunit
C7K70_RS03470	COG1294	oxidase, subunit
C7K70_RS03475	COG4890	Cyd operon protein YbgT
C7K70_RS03480	COG3790	cyd operon protein YbgE
C7K70_RS03485	COG0824	Thioesterase
C7K70_RS03490	COG0811	peptide transport
C7K70_RS03505	COG0823	Involved in the tonB-independent uptake of proteins
C7K70_RS03510	COG2885	chlorophyll binding
C7K70_RS03515	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C7K70_RS03590	COG0840	transmembrane signaling receptor activity
C7K70_RS03595	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C7K70_RS03600	COG0676	glucose-6-phosphate 1-epimerase activity
C7K70_RS03605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C7K70_RS03610	COG1640	4-alpha-glucanotransferase
C7K70_RS03615	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C7K70_RS03635	COG1051	belongs to the nudix hydrolase family
C7K70_RS03640	COG2130	NADP-dependent
C7K70_RS03645	COG1764	response to oxidative stress
C7K70_RS03650	COG1846	Transcriptional regulator
C7K70_RS03680	COG0561	phosphatase activity
C7K70_RS03695	COG0733	neurotransmitter:sodium symporter activity
C7K70_RS03705	COG0733	neurotransmitter:sodium symporter activity
C7K70_RS03730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7K70_RS03740	COG1794	racemase activity, acting on amino acids and derivatives
C7K70_RS03755	COG2731	YhcH YjgK YiaL family protein
C7K70_RS03765	COG0668	transmembrane transport
C7K70_RS03775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C7K70_RS03815	COG0583	DNA-binding transcription factor activity
C7K70_RS03820	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C7K70_RS03830	COG0488	(ABC) transporter
C7K70_RS03835	COG0517	IMP dehydrogenase activity
C7K70_RS03835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C7K70_RS03840	COG1585	Membrane protein implicated in regulation of membrane protease activity
C7K70_RS03845	COG0330	HflC and HflK could
C7K70_RS03850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C7K70_RS03850	COG1648	precorrin-2 dehydrogenase activity
C7K70_RS03855	COG0175	sulfate reduction
C7K70_RS03860	COG2895	sulfate adenylyltransferase (ATP) activity
C7K70_RS03865	COG3273	potassium ion transport
C7K70_RS03865	COG0471	metal ion transport
C7K70_RS03870	COG0529	Catalyzes the synthesis of activated sulfate
C7K70_RS03900	COG0625	glutathione transferase activity
C7K70_RS03925	COG1136	(ABC) transporter
C7K70_RS03940	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C7K70_RS03960	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C7K70_RS03965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C7K70_RS03970	COG0163	prenyltransferase activity
C7K70_RS03985	COG1131	(ABC) transporter
C7K70_RS03990	COG0842	Transport permease protein
C7K70_RS03995	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C7K70_RS04000	COG1924	4 iron, 4 sulfur cluster binding
C7K70_RS04020	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C7K70_RS04025	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C7K70_RS04040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7K70_RS04045	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C7K70_RS04050	COG1489	DNA binding
C7K70_RS04060	COG1643	Atp-dependent helicase
C7K70_RS04065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7K70_RS04070	COG0346	lactoylglutathione lyase activity
C7K70_RS04080	COG2076	Multidrug Resistance protein
C7K70_RS04090	COG3437	response regulator, receiver
C7K70_RS04090	COG0784	Response regulator, receiver
C7K70_RS04100	COG0671	phosphoesterase, PA-phosphatase related
C7K70_RS04115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C7K70_RS04120	COG0038	chloride channel
C7K70_RS04130	COG0316	Belongs to the HesB IscA family
C7K70_RS04160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C7K70_RS04170	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C7K70_RS04175	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C7K70_RS04180	COG1178	ABC-type Fe3 transport system permease component
C7K70_RS04185	COG4143	(ABC) transporter
C7K70_RS04200	COG0066	3-isopropylmalate dehydratase activity
C7K70_RS04205	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C7K70_RS04210	COG0473	3-isopropylmalate dehydrogenase activity
C7K70_RS04215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C7K70_RS04225	COG0671	phosphoesterase, PA-phosphatase related
C7K70_RS04230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C7K70_RS04240	COG0028	Belongs to the TPP enzyme family
C7K70_RS04255	COG0280	phosphate acetyltransferase
C7K70_RS04255	COG0857	belongs to the CobB CobQ family
C7K70_RS04260	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C7K70_RS04270	COG3013	Belongs to the UPF0304 family
C7K70_RS04275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C7K70_RS04280	COG2716	regulation of RNA biosynthetic process
C7K70_RS04290	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C7K70_RS04295	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C7K70_RS04310	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C7K70_RS04330	COG0784	Response regulator, receiver
C7K70_RS04330	COG5002	protein histidine kinase activity
C7K70_RS04330	COG2198	Histidine kinase
C7K70_RS04355	COG0840	transmembrane signaling receptor activity
C7K70_RS04365	COG1464	Belongs to the NlpA lipoprotein family
C7K70_RS04370	COG2011	ABC-type metal ion transport system permease component
C7K70_RS04375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C7K70_RS04400	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C7K70_RS04400	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C7K70_RS04405	COG0802	atpase or kinase
C7K70_RS04415	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C7K70_RS04420	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C7K70_RS04425	COG1923	regulation of RNA biosynthetic process
C7K70_RS04430	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C7K70_RS04435	COG0330	HflC and HflK could
C7K70_RS04440	COG0330	HflC and HflK could
C7K70_RS04445	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C7K70_RS04450	COG0142	geranyltranstransferase activity
C7K70_RS04455	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C7K70_RS04460	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C7K70_RS04465	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C7K70_RS04470	COG3314	Sporulation integral membrane protein YlbJ
C7K70_RS04475	COG0318	PFAM AMP-dependent synthetase and ligase
C7K70_RS04490	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C7K70_RS04495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7K70_RS04505	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C7K70_RS04510	COG2967	ApaG domain
C7K70_RS04515	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C7K70_RS04520	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C7K70_RS04530	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C7K70_RS04535	COG3178	'Phosphotransferase
C7K70_RS04540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C7K70_RS04545	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C7K70_RS04550	COG2252	PERMEase
C7K70_RS04560	COG0488	(ABC) transporter
C7K70_RS04575	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C7K70_RS04580	COG0741	lytic transglycosylase activity
C7K70_RS04600	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C7K70_RS04605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C7K70_RS04610	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7K70_RS04635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7K70_RS04645	COG3721	Heme iron utilization protein
C7K70_RS04650	COG0748	coenzyme F420 binding
C7K70_RS04670	COG4771	TonB-dependent receptor
C7K70_RS04680	COG2814	Major facilitator Superfamily
C7K70_RS04685	COG3655	Transcriptional regulator
C7K70_RS04695	COG2205	protein histidine kinase activity
C7K70_RS04695	COG2202	Pas domain
C7K70_RS04710	COG3397	chitin binding
C7K70_RS04715	COG2226	methyltransferase
C7K70_RS04725	COG1765	OsmC-like protein
C7K70_RS04740	COG3954	Phosphoribulokinase
C7K70_RS04745	COG2076	Multidrug Resistance protein
C7K70_RS04750	COG2076	Multidrug Resistance protein
C7K70_RS04755	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C7K70_RS04760	COG0726	polysaccharide deacetylase
C7K70_RS04765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7K70_RS04765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C7K70_RS04770	COG0463	Glycosyl transferase, family 2
C7K70_RS04775	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C7K70_RS04785	COG3089	Belongs to the UPF0270 family
C7K70_RS04790	COG3706	GGDEF domain
C7K70_RS04790	COG5001	Diguanylate cyclase
C7K70_RS04790	COG4251	negative regulation of phosphorylation
C7K70_RS04790	COG2203	Gaf domain
C7K70_RS04795	COG0429	hydrolase of the alpha beta-hydrolase fold
C7K70_RS04800	COG0835	chemotaxis
C7K70_RS04800	COG0784	Response regulator, receiver
C7K70_RS04810	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C7K70_RS04815	COG1047	Peptidyl-prolyl cis-trans
C7K70_RS04830	COG0545	Peptidyl-prolyl cis-trans isomerase
C7K70_RS04835	COG2204	response regulator
C7K70_RS04855	COG0737	Belongs to the 5'-nucleotidase family
C7K70_RS04860	COG2200	EAL domain
C7K70_RS04875	COG0305	Participates in initiation and elongation during chromosome replication
C7K70_RS04885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C7K70_RS04895	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C7K70_RS04900	COG0826	peptidase U32
C7K70_RS04905	COG2199	diguanylate cyclase activity
C7K70_RS04905	COG2200	EAL domain
C7K70_RS04905	COG2203	Gaf domain
C7K70_RS04935	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C7K70_RS04940	COG2201	protein-glutamate methylesterase activity
C7K70_RS04945	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C7K70_RS04955	COG0840	transmembrane signaling receptor activity
C7K70_RS04960	COG0835	chemotaxis
C7K70_RS04970	COG0643	Histidine kinase
C7K70_RS04970	COG2198	Histidine kinase
C7K70_RS04985	COG0840	transmembrane signaling receptor activity
C7K70_RS04990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7K70_RS05000	COG1280	lysine exporter protein (LysE YggA)
C7K70_RS05005	COG0826	peptidase U32
C7K70_RS05035	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C7K70_RS05060	COG0300	oxidoreductase activity
C7K70_RS05070	COG0840	transmembrane signaling receptor activity
C7K70_RS05080	COG2610	gluconate transmembrane transporter activity
C7K70_RS05085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7K70_RS05090	COG3622	Belongs to the hyi family
C7K70_RS05095	COG0235	Class ii aldolase
C7K70_RS05105	COG2084	Dehydrogenase
C7K70_RS05110	COG1349	DNA-binding transcription factor activity
C7K70_RS05135	COG1605	Chorismate mutase
C7K70_RS05135	COG0077	Prephenate dehydratase
C7K70_RS05165	COG3272	Protein of unknown function (DUF1722)
C7K70_RS05170	COG0789	Transcriptional regulator
C7K70_RS05175	COG0415	Belongs to the DNA photolyase family
C7K70_RS05185	COG4221	oxidoreductase activity
C7K70_RS05200	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C7K70_RS05225	COG0783	Belongs to the Dps family
C7K70_RS05230	COG1151	hydroxylamine reductase activity
C7K70_RS05240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C7K70_RS05245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C7K70_RS05245	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C7K70_RS05335	COG2003	Belongs to the UPF0758 family
C7K70_RS05385	COG4983	Phage plasmid primase, P4 family domain protein
C7K70_RS05395	COG2916	Histone family protein nucleoid-structuring protein H-NS
C7K70_RS05415	COG3501	Rhs element vgr protein
C7K70_RS05440	COG3209	COG3209 Rhs family protein
C7K70_RS05475	COG0582	viral genome integration into host DNA
C7K70_RS05505	COG0693	protein deglycase activity
C7K70_RS05510	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C7K70_RS05515	COG1666	GTP binding
C7K70_RS05520	COG3248	Nucleoside-binding outer membrane protein
C7K70_RS05525	COG2211	Major facilitator Superfamily
C7K70_RS05535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C7K70_RS05545	COG2813	Specifically methylates the guanine in position
C7K70_RS05550	COG0271	Belongs to the BolA IbaG family
C7K70_RS05555	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C7K70_RS05560	COG1805	sodium ion transport
C7K70_RS05565	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C7K70_RS05570	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C7K70_RS05575	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C7K70_RS05580	COG2871	sodium ion transport
C7K70_RS05585	COG1477	protein flavinylation
C7K70_RS05600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C7K70_RS05605	COG0840	transmembrane signaling receptor activity
C7K70_RS05610	COG0583	DNA-binding transcription factor activity
C7K70_RS05620	COG2363	Small membrane protein
C7K70_RS05625	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C7K70_RS05635	COG0473	3-isopropylmalate dehydrogenase activity
C7K70_RS05640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K70_RS05645	COG1611	Belongs to the LOG family
C7K70_RS05660	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C7K70_RS05660	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C7K70_RS05670	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
C7K70_RS05695	COG3098	single-species biofilm formation
C7K70_RS05700	COG0564	pseudouridine synthase activity
C7K70_RS05710	COG4580	involved in the transport of maltose and maltodextrins
C7K70_RS05720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K70_RS05720	COG1263	PTS System
C7K70_RS05730	COG2171	N-acyltransferase activity
C7K70_RS05735	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C7K70_RS05740	COG0024	Methionine aminopeptidase
C7K70_RS05745	COG0052	Belongs to the universal ribosomal protein uS2 family
C7K70_RS05750	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C7K70_RS05755	COG0528	UMP kinase activity
C7K70_RS05760	COG0233	cytoplasmic translational termination
C7K70_RS05765	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C7K70_RS05770	COG0575	Belongs to the CDS family
C7K70_RS05775	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C7K70_RS05780	COG0750	zinc metalloprotease
C7K70_RS05795	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C7K70_RS05800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C7K70_RS05805	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C7K70_RS05810	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C7K70_RS05815	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C7K70_RS05825	COG0825	malonyl-CoA metabolic process
C7K70_RS05830	COG3710	Transcriptional regulator
C7K70_RS05840	COG0531	amino acid
C7K70_RS05845	COG1982	Orn Lys Arg decarboxylase major
C7K70_RS05850	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C7K70_RS05865	COG0814	amino acid
C7K70_RS05880	COG0531	amino acid
C7K70_RS05890	COG0488	(ABC) transporter
C7K70_RS05900	COG3590	peptidase
C7K70_RS05910	COG3706	GGDEF domain
C7K70_RS05945	COG0366	Alpha amylase catalytic
C7K70_RS05960	COG0463	Glycosyl transferase, family 2
C7K70_RS05975	COG2989	Protein conserved in bacteria
C7K70_RS05980	COG3108	Peptidase M15
C7K70_RS05990	COG2860	membrane
C7K70_RS06000	COG1196	nuclear chromosome segregation
C7K70_RS06005	COG3115	cell septum assembly
C7K70_RS06010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C7K70_RS06020	COG1328	CTP reductase activity
C7K70_RS06025	COG0602	queuosine metabolic process
C7K70_RS06055	COG1566	PFAM secretion protein HlyD family protein
C7K70_RS06060	COG1846	Transcriptional regulator
C7K70_RS06075	COG0281	malic enzyme
C7K70_RS06080	COG3290	protein histidine kinase activity
C7K70_RS06085	COG4565	transcriptional regulatory protein
C7K70_RS06090	COG0697	spore germination
C7K70_RS06105	COG3284	Transcriptional regulator
C7K70_RS06110	COG1960	acyl-CoA dehydrogenase activity
C7K70_RS06115	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C7K70_RS06120	COG0346	lactoylglutathione lyase activity
C7K70_RS06125	COG0745	RESPONSE REGULATOR receiver
C7K70_RS06130	COG5002	protein histidine kinase activity
C7K70_RS06155	COG3142	Participates in the control of copper homeostasis
C7K70_RS06170	COG0545	Peptidyl-prolyl cis-trans isomerase
C7K70_RS06175	COG1131	(ABC) transporter
C7K70_RS06195	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C7K70_RS06205	COG0678	peroxiredoxin activity
C7K70_RS06215	COG0019	diaminopimelate decarboxylase activity
C7K70_RS06220	COG1115	amino acid carrier protein
C7K70_RS06225	COG0095	Lipoate-protein ligase
C7K70_RS06230	COG2233	PERMEase
C7K70_RS06245	COG0534	Mate efflux family protein
C7K70_RS06255	COG0281	malic enzyme
C7K70_RS06285	COG0733	neurotransmitter:sodium symporter activity
C7K70_RS06290	COG1752	Esterase of the alpha-beta hydrolase superfamily
C7K70_RS06300	COG1566	PFAM secretion protein HlyD family protein
C7K70_RS06305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7K70_RS06315	COG1032	radical SAM domain protein
C7K70_RS06355	COG0673	inositol 2-dehydrogenase activity
C7K70_RS06365	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C7K70_RS06370	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C7K70_RS06380	COG0739	heme binding
C7K70_RS06380	COG0741	lytic transglycosylase activity
C7K70_RS06380	COG1196	nuclear chromosome segregation
C7K70_RS06385	COG0366	Alpha amylase catalytic
C7K70_RS06405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C7K70_RS06415	COG0788	formyltetrahydrofolate deformylase activity
C7K70_RS06420	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C7K70_RS06430	COG3118	belongs to the thioredoxin family
C7K70_RS06435	COG2091	lysine biosynthetic process via aminoadipic acid
C7K70_RS06440	COG0791	NLP P60 protein
C7K70_RS06445	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C7K70_RS06460	COG1376	ErfK ybiS ycfS ynhG family protein
C7K70_RS06460	COG1388	LysM domain
C7K70_RS06475	COG3318	Belongs to the UPF0149 family
C7K70_RS06475	COG3012	SEC-C Motif Domain Protein
C7K70_RS06490	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C7K70_RS06540	COG2003	Belongs to the UPF0758 family
C7K70_RS06630	COG3311	Transcriptional regulator
C7K70_RS06640	COG0582	viral genome integration into host DNA
C7K70_RS06660	COG4869	propanediol catabolic process
C7K70_RS06670	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C7K70_RS06675	COG1882	Formate acetyltransferase
C7K70_RS06680	COG1454	alcohol dehydrogenase
C7K70_RS06680	COG1012	belongs to the aldehyde dehydrogenase family
C7K70_RS06690	COG1454	alcohol dehydrogenase
C7K70_RS06690	COG1012	belongs to the aldehyde dehydrogenase family
C7K70_RS06725	COG0583	DNA-binding transcription factor activity
C7K70_RS06730	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C7K70_RS06735	COG0243	molybdopterin cofactor binding
C7K70_RS06745	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C7K70_RS06755	COG1960	acyl-CoA dehydrogenase activity
C7K70_RS06760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7K70_RS06770	COG0469	pyruvate kinase activity
C7K70_RS06775	COG1737	Transcriptional regulator
C7K70_RS06795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C7K70_RS06810	COG1677	Flagellar hook-basal body complex protein FliE
C7K70_RS06820	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C7K70_RS06875	COG1684	flagellar biosynthetic protein fliR
C7K70_RS06885	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C7K70_RS06910	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C7K70_RS06915	COG0784	Response regulator, receiver
C7K70_RS06915	COG0643	Histidine kinase
C7K70_RS06915	COG2198	Histidine kinase
C7K70_RS06920	COG2201	protein-glutamate methylesterase activity
C7K70_RS06925	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C7K70_RS06930	COG1360	Flagellar Motor Protein
C7K70_RS06935	COG1192	Involved in chromosome partitioning
C7K70_RS06945	COG0835	chemotaxis
C7K70_RS06960	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C7K70_RS06965	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C7K70_RS06970	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C7K70_RS06975	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C7K70_RS06980	COG1138	Cytochrome C-type biogenesis protein
C7K70_RS06985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7K70_RS06990	COG4235	cytochrome complex assembly
C7K70_RS06990	COG3088	subunit of a heme lyase
C7K70_RS06995	COG3088	subunit of a heme lyase
C7K70_RS06995	COG4235	cytochrome complex assembly
C7K70_RS07010	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C7K70_RS07015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C7K70_RS07015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7K70_RS07030	COG0259	pyridoxamine-phosphate oxidase activity
C7K70_RS07035	COG0625	glutathione transferase activity
C7K70_RS07045	COG3153	acetyltransferase
C7K70_RS07050	COG2850	peptidyl-arginine hydroxylation
C7K70_RS07055	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C7K70_RS07060	COG2915	High frequency lysogenization protein hflD homolog
C7K70_RS07065	COG0482	sulfurtransferase activity
C7K70_RS07075	COG1187	pseudouridine synthase activity
C7K70_RS07085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K70_RS07100	COG5599	Phosphatase
C7K70_RS07105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K70_RS07105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K70_RS07105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K70_RS07125	COG0456	acetyltransferase
C7K70_RS07135	COG1609	Transcriptional regulator
C7K70_RS07140	COG1263	PTS System
C7K70_RS07140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K70_RS07145	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C7K70_RS07160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K70_RS07180	COG2207	Transcriptional regulator
C7K70_RS07185	COG0538	isocitrate dehydrogenase activity
C7K70_RS07195	COG3048	D-serine ammonia-lyase activity
C7K70_RS07200	COG0583	DNA-binding transcription factor activity
C7K70_RS07220	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C7K70_RS07225	COG2867	negative regulation of translational initiation
C7K70_RS07230	COG2914	Belongs to the UPF0125 (RnfH) family
C7K70_RS07235	COG0702	epimerase
C7K70_RS07240	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C7K70_RS07245	COG1454	alcohol dehydrogenase
C7K70_RS07255	COG0564	pseudouridine synthase activity
C7K70_RS07285	COG1280	lysine exporter protein (LysE YggA)
C7K70_RS07295	COG3263	regulation of cellular component size
C7K70_RS07305	COG3263	regulation of cellular component size
C7K70_RS07315	COG1876	peptidase activity
C7K70_RS07320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7K70_RS07325	COG1393	Belongs to the ArsC family
C7K70_RS07330	COG0583	DNA-binding transcription factor activity
C7K70_RS07340	COG3069	C4-dicarboxylate transmembrane transporter activity
C7K70_RS07355	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C7K70_RS07360	COG0017	Asparaginyl-tRNA synthetase
C7K70_RS07380	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C7K70_RS07385	COG0156	8-amino-7-oxononanoate synthase activity
C7K70_RS07390	COG1073	alpha beta
C7K70_RS07390	COG2226	methyltransferase
C7K70_RS07395	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C7K70_RS07400	COG0501	Belongs to the peptidase M48B family
C7K70_RS07410	COG3217	Mosc domain protein beta barrel domain protein
C7K70_RS07410	COG0633	Ferredoxin
C7K70_RS07410	COG3217	Mosc domain protein beta barrel domain protein
C7K70_RS07410	COG0633	Ferredoxin
C7K70_RS07420	COG1013	pyruvate-flavodoxin oxidoreductase activity
C7K70_RS07420	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C7K70_RS07420	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C7K70_RS07420	COG0674	pyruvate-flavodoxin oxidoreductase activity
C7K70_RS07425	COG2366	antibiotic biosynthetic process
C7K70_RS07445	COG0534	Mate efflux family protein
C7K70_RS07485	COG1309	transcriptional regulator
C7K70_RS07500	COG0791	NLP P60 protein
C7K70_RS07510	COG0583	DNA-binding transcription factor activity
C7K70_RS07515	COG0450	alkyl hydroperoxide reductase
C7K70_RS07535	COG0500	methyltransferase
C7K70_RS07540	COG4106	trans-aconitate 2-methyltransferase activity
C7K70_RS07545	COG1801	Protein of unknown function DUF72
C7K70_RS07550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C7K70_RS07555	COG0217	transcriptional regulatory protein
C7K70_RS07560	COG2194	sulfuric ester hydrolase activity
C7K70_RS07565	COG1940	carbohydrate kinase activity
C7K70_RS07565	COG1846	Transcriptional regulator
C7K70_RS07570	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C7K70_RS07575	COG0363	glucosamine-6-phosphate deaminase activity
C7K70_RS07580	COG1263	PTS System
C7K70_RS07580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K70_RS07580	COG2190	(PTS) system
C7K70_RS07595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7K70_RS07600	COG0735	belongs to the Fur family
C7K70_RS07610	COG0716	FMN binding
C7K70_RS07625	COG0596	Alpha beta hydrolase
C7K70_RS07630	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C7K70_RS07635	COG0033	Phosphoglucomutase
C7K70_RS07645	COG1846	Transcriptional regulator
C7K70_RS07660	COG2951	lytic endotransglycosylase activity
C7K70_RS07665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C7K70_RS07670	COG4136	ATPase activity
C7K70_RS07680	COG4134	Bacterial extracellular solute-binding protein
C7K70_RS07690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C7K70_RS07700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7K70_RS07705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C7K70_RS07715	COG0729	surface antigen
C7K70_RS07720	COG2911	Protein conserved in bacteria
C7K70_RS07740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C7K70_RS07750	COG0741	lytic transglycosylase activity
C7K70_RS07765	COG1607	acyl-coa hydrolase
C7K70_RS07775	COG3021	interspecies interaction between organisms
C7K70_RS07780	COG1388	LysM domain
C7K70_RS07780	COG0741	lytic transglycosylase activity
C7K70_RS07785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7K70_RS07790	COG2226	methyltransferase
C7K70_RS07795	COG0328	RNA-DNA hybrid ribonuclease activity
C7K70_RS07810	COG3437	response regulator, receiver
C7K70_RS07810	COG0784	Response regulator, receiver
C7K70_RS07815	COG1960	acyl-CoA dehydrogenase activity
C7K70_RS07820	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C7K70_RS07825	COG0121	glutamine amidotransferase
C7K70_RS07855	COG2197	response regulator
C7K70_RS07860	COG3850	Histidine kinase
C7K70_RS07865	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C7K70_RS07870	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
C7K70_RS07870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C7K70_RS07880	COG0243	molybdopterin cofactor binding
C7K70_RS07885	COG0437	4 iron, 4 sulfur cluster binding
C7K70_RS07890	COG0348	domain, Protein
C7K70_RS07900	COG3005	denitrification pathway
C7K70_RS07905	COG0521	Mo-molybdopterin cofactor biosynthetic process
C7K70_RS07910	COG0315	cyclic pyranopterin monophosphate synthase activity
C7K70_RS07915	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C7K70_RS07920	COG0314	molybdopterin synthase activity
C7K70_RS07935	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C7K70_RS07940	COG2267	carboxylic ester hydrolase activity
C7K70_RS07965	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C7K70_RS07975	COG0302	gtp cyclohydrolase
C7K70_RS07980	COG0840	transmembrane signaling receptor activity
C7K70_RS07985	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C7K70_RS07990	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C7K70_RS08000	COG0583	DNA-binding transcription factor activity
C7K70_RS08030	COG2195	Cleaves the N-terminal amino acid of tripeptides
C7K70_RS08050	COG1166	arginine decarboxylase activity
C7K70_RS08070	COG0814	amino acid
C7K70_RS08080	COG3681	Belongs to the UPF0597 family
C7K70_RS08085	COG2964	Protein conserved in bacteria
C7K70_RS08095	COG1061	Type III restriction enzyme res subunit
C7K70_RS08105	COG0346	lactoylglutathione lyase activity
C7K70_RS08125	COG1187	pseudouridine synthase activity
C7K70_RS08130	COG2807	transmembrane transport
C7K70_RS08140	COG0583	DNA-binding transcription factor activity
C7K70_RS08145	COG2271	Major facilitator Superfamily
C7K70_RS08175	COG2979	Protein of unknown function (DUF533)
C7K70_RS08185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7K70_RS08190	COG1271	oxidase subunit
C7K70_RS08195	COG1294	oxidase, subunit
C7K70_RS08205	COG2814	Major facilitator Superfamily
C7K70_RS08210	COG0656	L-ascorbic acid biosynthetic process
C7K70_RS08230	COG0583	DNA-binding transcription factor activity
C7K70_RS08235	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C7K70_RS08240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C7K70_RS08245	COG2271	Major facilitator Superfamily
C7K70_RS08250	COG1349	DNA-binding transcription factor activity
C7K70_RS08260	COG0584	glycerophosphoryl diester phosphodiesterase
C7K70_RS08265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C7K70_RS08270	COG1605	Chorismate mutase
C7K70_RS08270	COG0287	Prephenate dehydrogenase
C7K70_RS08275	COG0583	DNA-binding transcription factor activity
C7K70_RS08280	COG3085	chromosome segregation
C7K70_RS08285	COG4574	serine-type endopeptidase inhibitor activity
C7K70_RS08305	COG1770	oligopeptidase
C7K70_RS08310	COG4771	TonB-dependent receptor
C7K70_RS08315	COG3083	sulfuric ester hydrolase activity
C7K70_RS08320	COG3082	Protein of unknown function (DUF1414)
C7K70_RS08325	COG3081	Nucleoid-associated protein
C7K70_RS08335	COG1175	transmembrane transport
C7K70_RS08340	COG3833	ABC-type maltose transport systems, permease component
C7K70_RS08345	COG3842	ATPase activity
C7K70_RS08365	COG0425	Belongs to the sulfur carrier protein TusA family
C7K70_RS08370	COG4783	chaperone-mediated protein folding
C7K70_RS08380	COG1393	Belongs to the ArsC family
C7K70_RS08395	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
C7K70_RS08400	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C7K70_RS08405	COG2431	L-lysine efflux transmembrane transporter activity
C7K70_RS08415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K70_RS08435	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C7K70_RS08445	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7K70_RS08465	COG1538	Outer membrane efflux protein
C7K70_RS08470	COG0628	permease
C7K70_RS08480	COG2373	Large extracellular alpha-helical protein
C7K70_RS08485	COG4953	penicillin-binding protein 1C
C7K70_RS08495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7K70_RS08495	COG0301	tRNA thio-modification
C7K70_RS08515	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C7K70_RS08520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C7K70_RS08560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C7K70_RS08580	COG0483	inositol monophosphate 1-phosphatase activity
C7K70_RS08590	COG0625	glutathione transferase activity
C7K70_RS08595	COG2814	Major facilitator Superfamily
C7K70_RS08615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7K70_RS08620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7K70_RS08625	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C7K70_RS08630	COG0509	glycine decarboxylation via glycine cleavage system
C7K70_RS08635	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C7K70_RS08635	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C7K70_RS08640	COG0640	Transcriptional regulator
C7K70_RS08645	COG0798	PFAM Bile acid sodium symporter
C7K70_RS08650	COG1393	Belongs to the ArsC family
C7K70_RS08665	COG0477	Major facilitator Superfamily
C7K70_RS08670	COG3634	alkyl hydroperoxide reductase activity
C7K70_RS08680	COG0517	IMP dehydrogenase activity
C7K70_RS08685	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C7K70_RS08690	COG0343	queuine tRNA-ribosyltransferase activity
C7K70_RS08695	COG1862	Preprotein translocase
C7K70_RS08700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C7K70_RS08705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C7K70_RS08720	COG0826	peptidase U32
C7K70_RS08725	COG0826	peptidase U32
C7K70_RS08730	COG3154	lipid carrier protein
C7K70_RS08750	COG1104	cysteine desulfurase activity
C7K70_RS08755	COG0822	iron-sulfur transferase activity
C7K70_RS08765	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C7K70_RS08770	COG0443	Heat shock 70 kDa protein
C7K70_RS08775	COG0633	Ferredoxin
C7K70_RS08785	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C7K70_RS08790	COG0105	UTP biosynthetic process
C7K70_RS08795	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C7K70_RS08810	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C7K70_RS08815	COG0124	histidyl-tRNA synthetase
C7K70_RS08820	COG2976	Protein conserved in bacteria
C7K70_RS08825	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C7K70_RS08830	COG1160	GTP binding
C7K70_RS08835	COG1645	bacterial-type flagellum-dependent swarming motility
C7K70_RS08845	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C7K70_RS08850	COG0047	phosphoribosylformylglycinamidine synthase activity
C7K70_RS08850	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C7K70_RS08855	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C7K70_RS08855	COG2199	diguanylate cyclase activity
C7K70_RS08870	COG1007	ATP synthesis coupled electron transport
C7K70_RS08875	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7K70_RS08885	COG0713	ATP synthesis coupled electron transport
C7K70_RS08890	COG0839	Belongs to the complex I subunit 6 family
C7K70_RS08895	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7K70_RS08900	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C7K70_RS08905	COG1034	ATP synthesis coupled electron transport
C7K70_RS08920	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7K70_RS08920	COG0649	NAD binding
C7K70_RS08925	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7K70_RS08930	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7K70_RS08935	COG1360	Flagellar Motor Protein
C7K70_RS08940	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C7K70_RS08955	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C7K70_RS08975	COG0724	RNA recognition motif
C7K70_RS08980	COG4989	oxidoreductase activity
C7K70_RS09005	COG3437	response regulator, receiver
C7K70_RS09010	COG0583	DNA-binding transcription factor activity
C7K70_RS09020	COG3300	MHYT domain
C7K70_RS09020	COG5001	Diguanylate cyclase
C7K70_RS09025	COG0778	Nitroreductase
C7K70_RS09055	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C7K70_RS09060	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C7K70_RS09065	COG0539	negative regulation of cytoplasmic translation
C7K70_RS09070	COG0776	regulation of translation
C7K70_RS09080	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C7K70_RS09100	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C7K70_RS09105	COG0602	queuosine metabolic process
C7K70_RS09110	COG3530	Putative quorum-sensing-regulated virulence factor
C7K70_RS09115	COG2096	Adenosyltransferase
C7K70_RS09120	COG2916	Histone family protein nucleoid-structuring protein H-NS
C7K70_RS09125	COG1757	Na H antiporter
C7K70_RS09130	COG1435	thymidine kinase activity
C7K70_RS09235	COG3829	transcription factor binding
C7K70_RS09285	COG1301	dicarboxylic acid transport
C7K70_RS09305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C7K70_RS09320	COG0537	adenosine 5'-monophosphoramidase activity
C7K70_RS09355	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C7K70_RS09360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C7K70_RS09370	COG2354	Protein conserved in bacteria
C7K70_RS09385	COG2233	PERMEase
C7K70_RS09390	COG3150	esterase
C7K70_RS09395	COG1252	NADH dehydrogenase
C7K70_RS09415	COG0393	Putative heavy-metal-binding
C7K70_RS09425	COG1619	proteins homologs of microcin C7 resistance protein MccF
C7K70_RS09430	COG1368	sulfuric ester hydrolase activity
C7K70_RS09440	COG0527	aspartate kinase activity
C7K70_RS09445	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C7K70_RS09445	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C7K70_RS09450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7K70_RS09475	COG0596	Alpha beta hydrolase
C7K70_RS09480	COG0346	lactoylglutathione lyase activity
C7K70_RS09490	COG0583	DNA-binding transcription factor activity
C7K70_RS09495	COG1620	l-lactate permease
C7K70_RS09505	COG1139	Iron-sulfur cluster binding protein
C7K70_RS09530	COG0577	efflux transmembrane transporter activity
C7K70_RS09535	COG1136	(ABC) transporter
C7K70_RS09545	COG2814	Major facilitator Superfamily
C7K70_RS09565	COG0672	)-iron permease
C7K70_RS09595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K70_RS09595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K70_RS09605	COG2314	TM2 domain
C7K70_RS09615	COG0582	viral genome integration into host DNA
C7K70_RS09675	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K70_RS09675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K70_RS09760	COG1074	ATP-dependent DNA helicase activity
C7K70_RS09780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K70_RS09780	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K70_RS09795	COG2314	TM2 domain
C7K70_RS09805	COG0582	viral genome integration into host DNA
C7K70_RS09830	COG3617	BRO family, N-terminal domain
C7K70_RS09875	COG0659	secondary active sulfate transmembrane transporter activity
C7K70_RS09900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C7K70_RS09905	COG0840	transmembrane signaling receptor activity
C7K70_RS09915	COG2201	protein-glutamate methylesterase activity
C7K70_RS09930	COG3290	protein histidine kinase activity
C7K70_RS09930	COG0840	transmembrane signaling receptor activity
C7K70_RS09935	COG0643	Histidine kinase
C7K70_RS09935	COG2198	Histidine kinase
C7K70_RS09945	COG0745	RESPONSE REGULATOR receiver
C7K70_RS09950	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C7K70_RS09955	COG0437	4 iron, 4 sulfur cluster binding
C7K70_RS09960	COG5557	Pfam Polysulphide reductase, NrfD
C7K70_RS09965	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C7K70_RS09970	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C7K70_RS09975	COG1773	rubredoxin
C7K70_RS09985	COG0601	transmembrane transport
C7K70_RS09990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C7K70_RS09995	COG0444	Belongs to the ABC transporter superfamily
C7K70_RS10000	COG3842	ATPase activity
C7K70_RS10005	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C7K70_RS10010	COG0375	protein maturation
C7K70_RS10015	COG0309	Hydrogenase expression formation protein (HypE)
C7K70_RS10025	COG0298	carbon dioxide binding
C7K70_RS10030	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C7K70_RS10040	COG1921	L-seryl-tRNASec selenium transferase activity
C7K70_RS10045	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C7K70_RS10055	COG3260	NADH ubiquinone oxidoreductase 20
C7K70_RS10060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7K70_RS10065	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C7K70_RS10065	COG3261	NADH dehydrogenase
C7K70_RS10070	COG0650	Formate hydrogenlyase subunit 4
C7K70_RS10075	COG0651	ATP synthesis coupled electron transport
C7K70_RS10080	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C7K70_RS10085	COG3158	transport of potassium into the cell
C7K70_RS10090	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C7K70_RS10120	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C7K70_RS10130	COG0326	Molecular chaperone. Has ATPase activity
C7K70_RS10140	COG0563	adenylate kinase activity
C7K70_RS10145	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C7K70_RS10155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7K70_RS10170	COG3300	MHYT domain
C7K70_RS10170	COG5001	Diguanylate cyclase
C7K70_RS10175	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C7K70_RS10195	COG1021	2,3-dihydroxybenzoate-AMP ligase
C7K70_RS10200	COG3433	isochorismatase activity
C7K70_RS10200	COG1535	isochorismatase
C7K70_RS10205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C7K70_RS10210	COG1028	Short-chain dehydrogenase reductase Sdr
C7K70_RS10220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C7K70_RS10225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C7K70_RS10235	COG1120	ATPase activity
C7K70_RS10240	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7K70_RS10245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7K70_RS10250	COG4771	TonB-dependent receptor
C7K70_RS10295	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C7K70_RS10300	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C7K70_RS10305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C7K70_RS10310	COG0840	transmembrane signaling receptor activity
C7K70_RS10320	COG1570	exodeoxyribonuclease VII activity
C7K70_RS10325	COG0697	spore germination
C7K70_RS10345	COG3158	transport of potassium into the cell
C7K70_RS10350	COG0517	IMP dehydrogenase activity
C7K70_RS10350	COG0516	GMP reductase activity
C7K70_RS10355	COG0519	Catalyzes the synthesis of GMP from XMP
C7K70_RS10355	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C7K70_RS10390	COG2062	phosphohistidine phosphatase, SixA
C7K70_RS10400	COG0697	spore germination
C7K70_RS10405	COG4166	transmembrane transport
C7K70_RS10410	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C7K70_RS10415	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C7K70_RS10425	COG4591	ABC-type transport system involved in lipoprotein release permease component
C7K70_RS10430	COG1136	(ABC) transporter
C7K70_RS10435	COG4591	ABC-type transport system involved in lipoprotein release permease component
C7K70_RS10440	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C7K70_RS10455	COG0544	peptidyl-prolyl cis-trans isomerase activity
C7K70_RS10460	COG0740	serine-type endopeptidase activity
C7K70_RS10465	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C7K70_RS10470	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C7K70_RS10475	COG0776	regulation of translation
C7K70_RS10480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C7K70_RS10485	COG0488	(ABC) transporter
C7K70_RS10490	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C7K70_RS10495	COG3162	membrane
C7K70_RS10510	COG1024	Enoyl-CoA hydratase
C7K70_RS10515	COG1115	amino acid carrier protein
C7K70_RS10530	COG1584	GPR1 FUN34 yaaH family protein
C7K70_RS10565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C7K70_RS10570	COG1960	acyl-CoA dehydrogenase activity
C7K70_RS10580	COG1960	acyl-CoA dehydrogenase activity
C7K70_RS10585	COG1024	Enoyl-CoA hydratase
C7K70_RS10590	COG1024	Enoyl-CoA hydratase
C7K70_RS10600	COG1028	Short-chain dehydrogenase reductase Sdr
C7K70_RS10610	COG0730	response to heat
C7K70_RS10625	COG3706	GGDEF domain
C7K70_RS10630	COG0583	DNA-binding transcription factor activity
C7K70_RS10635	COG2723	6-phospho-beta-galactosidase activity
C7K70_RS10640	COG3300	MHYT domain
C7K70_RS10640	COG5001	Diguanylate cyclase
C7K70_RS10650	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C7K70_RS10660	COG0583	DNA-binding transcription factor activity
C7K70_RS10665	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C7K70_RS10670	COG0673	inositol 2-dehydrogenase activity
C7K70_RS10675	COG0583	DNA-binding transcription factor activity
C7K70_RS10685	COG1560	Kdo2-lipid A biosynthetic process
C7K70_RS10690	COG1560	Kdo2-lipid A biosynthetic process
C7K70_RS10715	COG0417	DNA replication proofreading
C7K70_RS10745	COG0534	Mate efflux family protein
C7K70_RS10755	COG0307	riboflavin synthase, alpha
C7K70_RS10765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K70_RS10770	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C7K70_RS10775	COG0697	spore germination
C7K70_RS10780	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C7K70_RS10820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7K70_RS10825	COG3099	Belongs to the UPF0263 family
C7K70_RS10830	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C7K70_RS10835	COG2894	cell division
C7K70_RS10840	COG0850	regulation of cytokinetic process
C7K70_RS10845	COG3100	YcgL domain-containing protein
C7K70_RS10850	COG2951	lytic endotransglycosylase activity
C7K70_RS10855	COG1760	l-serine dehydratase
C7K70_RS10865	COG1760	l-serine dehydratase
C7K70_RS10870	COG3123	guanosine phosphorylase activity
C7K70_RS11000	COG5301	cellulose 1,4-beta-cellobiosidase activity
C7K70_RS11025	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C7K70_RS11030	COG2067	long-chain fatty acid transport protein
C7K70_RS11035	COG2067	long-chain fatty acid transport protein
C7K70_RS11045	COG1595	DNA-templated transcription, initiation
C7K70_RS11075	COG0714	Associated with various cellular activities
C7K70_RS11080	COG0183	Belongs to the thiolase family
C7K70_RS11085	COG1250	3-hydroxyacyl-CoA dehydrogenase
C7K70_RS11085	COG1024	Enoyl-CoA hydratase
C7K70_RS11105	COG3829	transcription factor binding
C7K70_RS11110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C7K70_RS11115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C7K70_RS11120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7K70_RS11130	COG0549	Belongs to the carbamate kinase family
C7K70_RS11135	COG0697	spore germination
C7K70_RS11140	COG3608	succinylglutamate desuccinylase aspartoacylase
C7K70_RS11140	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C7K70_RS11145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C7K70_RS11150	COG2068	MobA-Related Protein
C7K70_RS11155	COG0493	'glutamate synthase
C7K70_RS11155	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C7K70_RS11160	COG0402	S-adenosylhomocysteine deaminase activity
C7K70_RS11165	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C7K70_RS11170	COG2080	2 iron, 2 sulfur cluster binding
C7K70_RS11170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C7K70_RS11175	COG2233	PERMEase
C7K70_RS11180	COG0402	S-adenosylhomocysteine deaminase activity
C7K70_RS11185	COG2252	PERMEase
C7K70_RS11190	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C7K70_RS11195	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C7K70_RS11200	COG2080	2 iron, 2 sulfur cluster binding
C7K70_RS11210	COG3134	Outer membrane lipoprotein
C7K70_RS11220	COG1288	antiporter activity
C7K70_RS11225	COG0318	PFAM AMP-dependent synthetase and ligase
C7K70_RS11230	COG0140	phosphoribosyl-ATP diphosphatase activity
C7K70_RS11230	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C7K70_RS11235	COG0107	imidazoleglycerol-phosphate synthase activity
C7K70_RS11240	COG2205	protein histidine kinase activity
C7K70_RS11240	COG0784	Response regulator, receiver
C7K70_RS11240	COG2198	Histidine kinase
C7K70_RS11245	COG2199	diguanylate cyclase activity
C7K70_RS11250	COG3437	response regulator, receiver
C7K70_RS11255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C7K70_RS11260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C7K70_RS11265	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C7K70_RS11265	COG0131	Imidazoleglycerol-phosphate dehydratase
C7K70_RS11270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C7K70_RS11275	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C7K70_RS11280	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C7K70_RS11290	COG1199	ATP-dependent helicase activity
C7K70_RS11300	COG1214	PFAM Peptidase M22, glycoprotease
C7K70_RS11310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C7K70_RS11310	COG0596	Alpha beta hydrolase
C7K70_RS11310	COG2226	methyltransferase
C7K70_RS11315	COG0318	PFAM AMP-dependent synthetase and ligase
C7K70_RS11335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C7K70_RS11340	COG2832	Protein of unknown function (DUF454)
C7K70_RS11345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7K70_RS11355	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C7K70_RS11375	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C7K70_RS11375	COG0617	tRNA 3'-terminal CCA addition
C7K70_RS11375	COG0517	IMP dehydrogenase activity
C7K70_RS11380	COG1643	Atp-dependent helicase
C7K70_RS11390	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C7K70_RS11400	COG3437	response regulator, receiver
C7K70_RS11405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7K70_RS11410	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C7K70_RS11415	COG0709	Synthesizes selenophosphate from selenide and ATP
C7K70_RS11430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C7K70_RS11440	COG1254	Belongs to the acylphosphatase family
C7K70_RS11445	COG0625	glutathione transferase activity
C7K70_RS11450	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K70_RS11450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K70_RS11455	COG0489	protein tyrosine kinase activity
C7K70_RS11460	COG0572	uridine kinase
C7K70_RS11465	COG0717	Belongs to the dCTP deaminase family
C7K70_RS11475	COG0306	phosphate transporter
C7K70_RS11480	COG1530	ribonuclease E activity
C7K70_RS11485	COG0564	pseudouridine synthase activity
C7K70_RS11490	COG0546	phosphoglycolate phosphatase activity
C7K70_RS11495	COG0424	maF-like protein
C7K70_RS11500	COG2814	Major facilitator Superfamily
C7K70_RS11515	COG1399	metal-binding, possibly nucleic acid-binding protein
C7K70_RS11520	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C7K70_RS11525	COG0416	fatty acid biosynthetic process
C7K70_RS11530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7K70_RS11540	COG1028	Short-chain dehydrogenase reductase Sdr
C7K70_RS11545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7K70_RS11555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C7K70_RS11560	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C7K70_RS11565	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C7K70_RS11570	COG0470	DNA polymerase III
C7K70_RS11575	COG0084	hydrolase, TatD family'
C7K70_RS11590	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C7K70_RS11590	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C7K70_RS11595	COG3008	intermembrane lipid transfer
C7K70_RS11600	COG2995	paraquat-inducible protein a
C7K70_RS11610	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C7K70_RS11615	COG0372	Belongs to the citrate synthase family
C7K70_RS11660	COG4221	oxidoreductase activity
C7K70_RS11670	COG3141	response to X-ray
C7K70_RS11695	COG4128	Pfam Zonular occludens toxin
C7K70_RS11735	COG1067	ATP-dependent peptidase activity
C7K70_RS11740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C7K70_RS11755	COG0488	(ABC) transporter
C7K70_RS11765	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C7K70_RS11765	COG0116	Belongs to the methyltransferase superfamily
C7K70_RS11775	COG0167	dihydroorotate dehydrogenase activity
C7K70_RS11780	COG2902	Dehydrogenase
C7K70_RS11790	COG0308	aminopeptidase N
C7K70_RS11800	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C7K70_RS11805	COG1956	GAF domain-containing protein
C7K70_RS11815	COG3278	Belongs to the heme-copper respiratory oxidase family
C7K70_RS11830	COG2010	Cytochrome c
C7K70_RS11855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7K70_RS11860	COG0589	response to stress
C7K70_RS11865	COG0037	tRNA processing
C7K70_RS11885	COG1869	D-ribose catabolic process
C7K70_RS11890	COG1129	ABC transporter
C7K70_RS11895	COG1172	Belongs to the binding-protein-dependent transport system permease family
C7K70_RS11900	COG1879	ABC-type sugar transport system periplasmic component
C7K70_RS11905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7K70_RS11910	COG1609	Transcriptional regulator
C7K70_RS11915	COG3300	MHYT domain
C7K70_RS11915	COG5001	Diguanylate cyclase
C7K70_RS11945	COG0776	regulation of translation
C7K70_RS11950	COG0072	phenylalanine-tRNA ligase activity
C7K70_RS11950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K70_RS11955	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C7K70_RS11960	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C7K70_RS11965	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C7K70_RS11970	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C7K70_RS11975	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C7K70_RS11995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C7K70_RS12005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C7K70_RS12010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C7K70_RS12015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C7K70_RS12020	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C7K70_RS12025	COG3313	Fe-S protein
C7K70_RS12035	COG3716	PTS system mannose fructose sorbose family IID component
C7K70_RS12040	COG3715	PTS system
C7K70_RS12045	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K70_RS12045	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K70_RS12060	COG1609	Transcriptional regulator
C7K70_RS12065	COG2140	Oxalate decarboxylase
C7K70_RS12070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K70_RS12070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K70_RS12070	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C7K70_RS12075	COG1105	Belongs to the carbohydrate kinase PfkB family
C7K70_RS12080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K70_RS12080	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K70_RS12085	COG1609	Transcriptional regulator
C7K70_RS12090	COG0814	amino acid
C7K70_RS12100	COG5654	RES domain protein
C7K70_RS12105	COG0513	Belongs to the DEAD box helicase family
C7K70_RS12115	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C7K70_RS12120	COG2890	protein-(glutamine-N5) methyltransferase activity
C7K70_RS12125	COG2840	Smr protein MutS2
C7K70_RS12160	COG2824	Alkylphosphonate utilization operon protein PhnA
C7K70_RS12175	COG0384	phenazine biosynthesis protein PhzF
C7K70_RS12205	COG0242	peptide deformylase activity
C7K70_RS12225	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C7K70_RS12230	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C7K70_RS12240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C7K70_RS12245	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C7K70_RS12255	COG0205	6-phosphofructokinase activity
C7K70_RS12260	COG1473	amidohydrolase
C7K70_RS12265	COG1011	Hydrolase
C7K70_RS12270	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C7K70_RS12320	COG3593	DNA synthesis involved in DNA repair
C7K70_RS12335	COG0583	DNA-binding transcription factor activity
C7K70_RS12340	COG0730	response to heat
C7K70_RS12345	COG3148	PFAM DTW domain containing protein
C7K70_RS12355	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7K70_RS12365	COG0386	Belongs to the glutathione peroxidase family
C7K70_RS12370	COG0513	Belongs to the DEAD box helicase family
C7K70_RS12375	COG0456	acetyltransferase
C7K70_RS12385	COG1742	UPF0060 membrane protein
C7K70_RS12415	COG2329	Antibiotic biosynthesis monooxygenase
C7K70_RS12420	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C7K70_RS12440	COG3243	poly(R)-hydroxyalkanoic acid synthase
C7K70_RS12450	COG2501	S4 domain
C7K70_RS12465	COG1132	(ABC) transporter
C7K70_RS12475	COG1132	(ABC) transporter
C7K70_RS12485	COG3118	belongs to the thioredoxin family
C7K70_RS12490	COG0471	metal ion transport
C7K70_RS12495	COG0058	SHG alpha-glucan phosphorylase activity
C7K70_RS12535	COG0814	amino acid
C7K70_RS12540	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C7K70_RS12545	COG0514	ATP-dependent DNA helicase (RecQ)
C7K70_RS12550	COG2766	serine protein kinase
C7K70_RS12560	COG2719	SpoVR family
C7K70_RS12565	COG2186	Transcriptional regulator
C7K70_RS12570	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C7K70_RS12575	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C7K70_RS12580	COG0586	Pfam SNARE associated Golgi protein
C7K70_RS12590	COG0556	nucleotide-excision repair
C7K70_RS12605	COG0569	domain protein
C7K70_RS12605	COG2985	domain, Protein
C7K70_RS12610	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C7K70_RS12630	COG4565	transcriptional regulatory protein
C7K70_RS12635	COG3290	protein histidine kinase activity
C7K70_RS12640	COG1846	Transcriptional regulator
C7K70_RS12640	COG1940	carbohydrate kinase activity
C7K70_RS12645	COG0840	transmembrane signaling receptor activity
C7K70_RS12650	COG3012	SEC-C Motif Domain Protein
C7K70_RS12655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C7K70_RS12660	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C7K70_RS12665	COG0247	lactate metabolic process
C7K70_RS12675	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C7K70_RS12680	COG0437	4 iron, 4 sulfur cluster binding
C7K70_RS12685	COG3301	Polysulphide reductase, NrfD
C7K70_RS12690	COG1138	Cytochrome C-type biogenesis protein
C7K70_RS12695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7K70_RS12700	COG4235	cytochrome complex assembly
C7K70_RS12700	COG3088	subunit of a heme lyase
C7K70_RS12705	COG1051	belongs to the nudix hydrolase family
C7K70_RS12715	COG3033	Beta-eliminating lyase
C7K70_RS12725	COG3046	protein related to deoxyribodipyrimidine photolyase
C7K70_RS12730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7K70_RS12755	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C7K70_RS12770	COG4774	siderophore transport
C7K70_RS12775	COG4977	sequence-specific DNA binding
C7K70_RS12785	COG0583	DNA-binding transcription factor activity
C7K70_RS12790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7K70_RS12805	COG0612	Peptidase, M16
C7K70_RS12810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C7K70_RS12820	COG1944	ATP diphosphatase activity
C7K70_RS12825	COG2116	formate transmembrane transporter activity
C7K70_RS12830	COG1882	Formate acetyltransferase
C7K70_RS12835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K70_RS12845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C7K70_RS12855	COG1840	ABC-type Fe3 transport system, periplasmic component
C7K70_RS12860	COG3842	ATPase activity
C7K70_RS12870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7K70_RS12875	COG2983	Belongs to the UPF0260 family
C7K70_RS12880	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C7K70_RS12885	COG0045	succinate-CoA ligase (ADP-forming) activity
C7K70_RS12890	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7K70_RS12895	COG0567	Dehydrogenase, E1 component
C7K70_RS12905	COG1053	succinate dehydrogenase
C7K70_RS12910	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C7K70_RS12935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C7K70_RS12940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7K70_RS12940	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C7K70_RS12950	COG3069	C4-dicarboxylate transmembrane transporter activity
C7K70_RS12965	COG1451	nucleotide metabolic process
C7K70_RS12980	COG0254	rRNA binding
C7K70_RS12985	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C7K70_RS12995	COG0583	DNA-binding transcription factor activity
C7K70_RS13005	COG1172	Belongs to the binding-protein-dependent transport system permease family
C7K70_RS13015	COG1879	ABC-type sugar transport system periplasmic component
C7K70_RS13020	COG1069	ribulokinase activity
C7K70_RS13030	COG2160	L-arabinose isomerase activity
C7K70_RS13035	COG2925	Exonuclease
C7K70_RS13045	COG3345	alpha-galactosidase
C7K70_RS13050	COG1380	Effector of murein hydrolase LrgA
C7K70_RS13055	COG1346	cytolysis
C7K70_RS13060	COG0295	cytidine deaminase activity
C7K70_RS13065	COG1022	Amp-dependent synthetase and ligase
C7K70_RS13080	COG0861	Integral membrane protein TerC family
C7K70_RS13085	COG2885	chlorophyll binding
C7K70_RS13090	COG2199	diguanylate cyclase activity
C7K70_RS13110	COG2154	pterin-4-alpha-carbinolamine dehydratase
C7K70_RS13120	COG3768	UPF0283 membrane protein
C7K70_RS13125	COG3106	COG3106 Predicted ATPase
C7K70_RS13140	COG1842	Phage shock protein A
C7K70_RS13145	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C7K70_RS13155	COG4168	peptide transport system, permease
C7K70_RS13160	COG4171	peptide transport system, permease
C7K70_RS13170	COG4172	Belongs to the ABC transporter superfamily
C7K70_RS13180	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C7K70_RS13185	COG1286	toxin biosynthetic process
C7K70_RS13190	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C7K70_RS13200	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C7K70_RS13205	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C7K70_RS13210	COG0531	amino acid
C7K70_RS13210	COG1674	ftsk spoiiie
C7K70_RS13220	COG0686	Belongs to the AlaDH PNT family
C7K70_RS13225	COG0492	ferredoxin-NADP+ reductase activity
C7K70_RS13230	COG3706	GGDEF domain
C7K70_RS13235	COG3134	Outer membrane lipoprotein
C7K70_RS13240	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C7K70_RS13245	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C7K70_RS13250	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C7K70_RS13255	COG0542	response to heat
C7K70_RS13260	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C7K70_RS13265	COG1278	Cold shock
C7K70_RS13270	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C7K70_RS13300	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C7K70_RS13305	COG0861	Integral membrane protein TerC family
C7K70_RS13320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C7K70_RS13325	COG0601	transmembrane transport
C7K70_RS13335	COG2095	MarC family integral membrane protein
C7K70_RS13345	COG1454	alcohol dehydrogenase
C7K70_RS13345	COG1012	belongs to the aldehyde dehydrogenase family
C7K70_RS13350	COG2199	diguanylate cyclase activity
C7K70_RS13350	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C7K70_RS13355	COG3275	phosphorelay sensor kinase activity
C7K70_RS13360	COG3279	Response regulator of the LytR AlgR family
C7K70_RS13365	COG1966	Carbon starvation protein
C7K70_RS13375	COG1566	PFAM secretion protein HlyD family protein
C7K70_RS13380	COG1061	Type III restriction enzyme res subunit
C7K70_RS13385	COG2027	D-alanyl-D-alanine carboxypeptidase
C7K70_RS13390	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C7K70_RS13400	COG0436	Aminotransferase
C7K70_RS13405	COG1288	antiporter activity
C7K70_RS13410	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C7K70_RS13430	COG0697	spore germination
C7K70_RS13435	COG4657	Part of a membrane complex involved in electron transport
C7K70_RS13440	COG2878	Part of a membrane complex involved in electron transport
C7K70_RS13450	COG4658	electron transport chain
C7K70_RS13455	COG4659	FMN binding
C7K70_RS13460	COG4660	Part of a membrane complex involved in electron transport
C7K70_RS13465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C7K70_RS13470	COG0346	lactoylglutathione lyase activity
C7K70_RS13485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C7K70_RS13490	COG2056	Na+-H+ antiporter family
C7K70_RS13500	COG2050	protein possibly involved in aromatic compounds catabolism
C7K70_RS13510	COG0247	lactate metabolic process
C7K70_RS13510	COG0277	FAD linked oxidase domain protein
C7K70_RS13520	COG1253	flavin adenine dinucleotide binding
C7K70_RS13525	COG1902	pentaerythritol trinitrate reductase activity
C7K70_RS13535	COG0647	UMP catabolic process
C7K70_RS13540	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C7K70_RS13540	COG4651	solute:proton antiporter activity
C7K70_RS13550	COG0367	asparagine synthase
C7K70_RS13560	COG0625	glutathione transferase activity
C7K70_RS13565	COG0625	glutathione transferase activity
C7K70_RS13575	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C7K70_RS13590	COG0564	pseudouridine synthase activity
C7K70_RS13595	COG5001	Diguanylate cyclase
C7K70_RS13600	COG0840	transmembrane signaling receptor activity
C7K70_RS13610	COG0392	lysyltransferase activity
C7K70_RS13610	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C7K70_RS13620	COG2194	sulfuric ester hydrolase activity
C7K70_RS13635	COG1317	bacterial-type flagellum organization
C7K70_RS13795	COG4790	Type iii secretion
C7K70_RS13800	COG4794	Type iii secretion
C7K70_RS13805	COG4791	protein targeting
C7K70_RS13810	COG4792	protein secretion
C7K70_RS13820	COG0582	viral genome integration into host DNA
C7K70_RS13885	COG3209	COG3209 Rhs family protein
C7K70_RS13935	COG3501	Rhs element vgr protein
C7K70_RS13970	COG0670	Belongs to the BI1 family
C7K70_RS13975	COG1289	transmembrane transporter activity
C7K70_RS13980	COG2920	part of a sulfur-relay system
C7K70_RS13985	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C7K70_RS13990	COG0285	dihydrofolate synthase activity
C7K70_RS13995	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C7K70_RS14000	COG0101	tRNA pseudouridine synthase activity
C7K70_RS14010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C7K70_RS14015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7K70_RS14020	COG0671	phosphoesterase, PA-phosphatase related
C7K70_RS14025	COG1464	Belongs to the NlpA lipoprotein family
C7K70_RS14065	COG0574	Belongs to the PEP-utilizing enzyme family
C7K70_RS14065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C7K70_RS14070	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C7K70_RS14095	COG2304	oxidoreductase activity
C7K70_RS14135	COG1242	4 iron, 4 sulfur cluster binding
C7K70_RS14145	COG0070	glutamate synthase
C7K70_RS14145	COG0069	glutamate synthase activity
C7K70_RS14145	COG0067	glutamate synthase
C7K70_RS14150	COG0493	'glutamate synthase
C7K70_RS14155	COG1126	abc transporter atp-binding protein
C7K70_RS14160	COG0765	amino acid transport
C7K70_RS14165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K70_RS14180	COG0789	Transcriptional regulator
C7K70_RS14195	COG4104	PAAR repeat-containing protein
C7K70_RS14205	COG0513	Belongs to the DEAD box helicase family
C7K70_RS14210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7K70_RS14240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C7K70_RS14245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C7K70_RS14250	COG0505	Belongs to the CarA family
C7K70_RS14255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C7K70_RS14270	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C7K70_RS14275	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C7K70_RS14280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7K70_RS14285	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C7K70_RS14290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C7K70_RS14300	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
C7K70_RS14310	COG2205	protein histidine kinase activity
C7K70_RS14310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K70_RS14325	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C7K70_RS14350	COG0023	Translation Initiation Factor
C7K70_RS14355	COG2119	membrane
C7K70_RS14385	COG2203	Gaf domain
C7K70_RS14385	COG2199	diguanylate cyclase activity
C7K70_RS14405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C7K70_RS14415	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C7K70_RS14420	COG3301	Polysulphide reductase, NrfD
C7K70_RS14425	COG0437	4 iron, 4 sulfur cluster binding
C7K70_RS14430	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C7K70_RS14475	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
C7K70_RS14500	COG0322	excinuclease ABC activity
C7K70_RS14505	COG2197	response regulator
C7K70_RS14510	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C7K70_RS14515	COG2835	tetraacyldisaccharide 4'-kinase activity
C7K70_RS14520	COG1663	tetraacyldisaccharide 4'-kinase activity
C7K70_RS14530	COG2333	competence protein COMEC
C7K70_RS14530	COG0658	competence protein
C7K70_RS14545	COG0433	COG0433 Predicted ATPase
C7K70_RS14550	COG1448	Aminotransferase
C7K70_RS14565	COG1199	ATP-dependent helicase activity
C7K70_RS14575	COG0123	including yeast histone deacetylase and acetoin utilization protein
C7K70_RS14580	COG0477	Major facilitator Superfamily
C7K70_RS14585	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C7K70_RS14610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7K70_RS14625	COG2271	Major facilitator Superfamily
C7K70_RS14635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K70_RS14640	COG0765	amino acid transport
C7K70_RS14645	COG1126	abc transporter atp-binding protein
C7K70_RS14665	COG0531	amino acid
C7K70_RS14680	COG1253	flavin adenine dinucleotide binding
C7K70_RS14685	COG4974	Belongs to the 'phage' integrase family
C7K70_RS14755	COG4695	Portal protein
C7K70_RS14895	COG0704	Plays a role in the regulation of phosphate uptake
C7K70_RS14900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C7K70_RS14905	COG0581	inorganic phosphate transmembrane transporter activity
C7K70_RS14910	COG0573	inorganic phosphate transmembrane transporter activity
C7K70_RS14915	COG0590	tRNA wobble adenosine to inosine editing
C7K70_RS14925	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C7K70_RS14945	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C7K70_RS14950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C7K70_RS14955	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C7K70_RS14960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C7K70_RS14985	COG2716	regulation of RNA biosynthetic process
C7K70_RS14990	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C7K70_RS15000	COG2239	Acts as a magnesium transporter
C7K70_RS15010	COG1256	bacterial-type flagellum assembly
C7K70_RS15020	COG1706	bacterial-type flagellum-dependent cell motility
C7K70_RS15025	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C7K70_RS15035	COG4787	bacterial-type flagellum-dependent cell motility
C7K70_RS15055	COG1815	bacterial-type flagellum-dependent cell motility
C7K70_RS15060	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C7K70_RS15065	COG0784	Response regulator, receiver
C7K70_RS15065	COG0835	chemotaxis
C7K70_RS15070	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C7K70_RS15085	COG0622	Phosphoesterase
C7K70_RS15120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C7K70_RS15125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C7K70_RS15130	COG1882	Formate acetyltransferase
C7K70_RS15135	COG1349	DNA-binding transcription factor activity
C7K70_RS15140	COG0697	spore germination
C7K70_RS15170	COG1278	Cold shock
C7K70_RS15210	COG3132	Protein of unknown function, DUF480
C7K70_RS15220	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C7K70_RS15230	COG0438	transferase activity, transferring glycosyl groups
C7K70_RS15235	COG1215	transferase activity, transferring glycosyl groups
C7K70_RS15250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C7K70_RS15265	COG0529	Catalyzes the synthesis of activated sulfate
C7K70_RS15270	COG0490	domain, Protein
C7K70_RS15270	COG0471	metal ion transport
C7K70_RS15275	COG2895	sulfate adenylyltransferase (ATP) activity
C7K70_RS15285	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C7K70_RS15290	COG1215	transferase activity, transferring glycosyl groups
C7K70_RS15325	COG1450	Type ii and iii secretion system protein
C7K70_RS15375	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7K70_RS15395	COG1091	dTDP-4-dehydrorhamnose reductase activity
C7K70_RS15410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7K70_RS15415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7K70_RS15420	COG1309	transcriptional regulator
C7K70_RS15435	COG1946	Acyl-CoA thioesterase
C7K70_RS15445	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C7K70_RS15455	COG0009	L-threonylcarbamoyladenylate synthase
C7K70_RS15465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C7K70_RS15470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C7K70_RS15470	COG0512	Glutamine amidotransferase of anthranilate synthase
C7K70_RS15475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C7K70_RS15480	COG0135	phosphoribosylanthranilate isomerase activity
C7K70_RS15480	COG0134	indole-3-glycerol-phosphate synthase activity
C7K70_RS15485	COG0133	tryptophan synthase activity
C7K70_RS15490	COG0159	tryptophan synthase activity
C7K70_RS15535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C7K70_RS15545	COG4521	taurine ABC transporter
C7K70_RS15550	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C7K70_RS15555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C7K70_RS15560	COG2175	clavaminate synthase activity
C7K70_RS15570	COG2814	Major facilitator Superfamily
C7K70_RS15575	COG0109	protoheme IX farnesyltransferase activity
C7K70_RS15580	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C7K70_RS15585	COG1845	cytochrome c oxidase, subunit III
C7K70_RS15590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C7K70_RS15595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C7K70_RS15640	COG2211	Major facilitator Superfamily
C7K70_RS15655	COG0708	Exodeoxyribonuclease III
C7K70_RS15675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7K70_RS15680	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7K70_RS15700	COG0095	Lipoate-protein ligase
C7K70_RS15730	COG0640	Transcriptional regulator
C7K70_RS15745	COG1285	pathogenesis
C7K70_RS15775	COG0484	heat shock protein binding
C7K70_RS15780	COG0443	Heat shock 70 kDa protein
C7K70_RS15785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C7K70_RS15790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C7K70_RS15795	COG0497	DNA recombination
C7K70_RS15800	COG1227	inorganic diphosphatase activity
C7K70_RS15810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7K70_RS15815	COG0577	efflux transmembrane transporter activity
C7K70_RS15815	COG1136	(ABC) transporter
C7K70_RS15825	COG2375	cellular response to nickel ion
C7K70_RS15835	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C7K70_RS15855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7K70_RS15860	COG1396	sequence-specific DNA binding
C7K70_RS15860	COG1917	Cupin 2, conserved barrel domain protein
C7K70_RS15875	COG0531	amino acid
C7K70_RS15885	COG0531	amino acid
C7K70_RS15895	COG1283	sodium-dependent phosphate transmembrane transporter activity
C7K70_RS15905	COG3384	dioxygenase
C7K70_RS15910	COG2205	protein histidine kinase activity
C7K70_RS15910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K70_RS15925	COG0813	purine-nucleoside phosphorylase activity
C7K70_RS15945	COG0488	(ABC) transporter
C7K70_RS15950	COG4319	ketosteroid isomerase
C7K70_RS15955	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C7K70_RS15960	COG0083	homoserine kinase activity
C7K70_RS15975	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C7K70_RS15980	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C7K70_RS15995	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C7K70_RS16005	COG0745	RESPONSE REGULATOR receiver
C7K70_RS16020	COG4988	ABC transporter
C7K70_RS16025	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C7K70_RS16045	COG1720	tRNA m6t6A37 methyltransferase activity
C7K70_RS16060	COG0542	response to heat
C7K70_RS16065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C7K70_RS16070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K70_RS16080	COG2190	(PTS) system
C7K70_RS16095	COG3038	cytochrome b561
C7K70_RS16110	COG0419	ATPase involved in DNA repair
C7K70_RS16115	COG0420	3'-5' exonuclease activity
C7K70_RS16125	COG2974	May be involved in recombination
C7K70_RS16135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C7K70_RS16135	COG4651	solute:proton antiporter activity
C7K70_RS16150	COG0469	pyruvate kinase activity
C7K70_RS16155	COG1196	nuclear chromosome segregation
C7K70_RS16155	COG3264	Mechanosensitive ion channel
C7K70_RS16165	COG2706	6-phosphogluconolactonase activity
C7K70_RS16185	COG0281	malic enzyme
C7K70_RS16200	COG0437	4 iron, 4 sulfur cluster binding
C7K70_RS16205	COG3383	formate dehydrogenase (NAD+) activity
C7K70_RS16205	COG3383	formate dehydrogenase (NAD+) activity
C7K70_RS16235	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C7K70_RS16240	COG1910	domain protein
C7K70_RS16245	COG3852	Histidine kinase
C7K70_RS16250	COG2204	response regulator
C7K70_RS16260	COG4662	Binding-protein-dependent transport system inner membrane component
C7K70_RS16270	COG0746	molybdenum cofactor guanylyltransferase activity
C7K70_RS16275	COG0303	'Molybdopterin
C7K70_RS16280	COG1289	transmembrane transporter activity
C7K70_RS16285	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C7K70_RS16315	COG3220	belongs to the UPF0276 family
C7K70_RS16350	COG0784	Response regulator, receiver
C7K70_RS16350	COG2205	protein histidine kinase activity
C7K70_RS16355	COG4166	transmembrane transport
C7K70_RS16360	COG0601	transmembrane transport
C7K70_RS16365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C7K70_RS16370	COG0444	Belongs to the ABC transporter superfamily
C7K70_RS16375	COG4608	Belongs to the ABC transporter superfamily
C7K70_RS16385	COG2971	BadF BadG BcrA BcrD
C7K70_RS16395	COG0840	transmembrane signaling receptor activity
C7K70_RS16415	COG3724	N-succinylarginine dihydrolase activity
C7K70_RS16420	COG0616	signal peptide processing
C7K70_RS16425	COG1028	Short-chain dehydrogenase reductase Sdr
C7K70_RS16430	COG0583	DNA-binding transcription factor activity
C7K70_RS16440	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C7K70_RS16450	COG0583	DNA-binding transcription factor activity
C7K70_RS16455	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C7K70_RS16460	COG1881	PFAM PEBP family protein
C7K70_RS16470	COG3408	Glycogen debranching enzyme
C7K70_RS16470	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C7K70_RS16475	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C7K70_RS16480	COG0739	heme binding
C7K70_RS16485	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C7K70_RS16515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C7K70_RS16525	COG3091	SprT-like family
C7K70_RS16535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C7K70_RS16540	COG0189	ligase activity
C7K70_RS16550	COG1678	Uncharacterized ACR, COG1678
C7K70_RS16555	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C7K70_RS16560	COG3104	oligopeptide transport
C7K70_RS16570	COG0714	Associated with various cellular activities
C7K70_RS16585	COG1115	amino acid carrier protein
C7K70_RS16590	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C7K70_RS16605	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C7K70_RS16615	COG1301	dicarboxylic acid transport
C7K70_RS16625	COG2912	Transglutaminase-like superfamily
C7K70_RS16635	COG2890	protein-(glutamine-N5) methyltransferase activity
C7K70_RS16640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C7K70_RS16645	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C7K70_RS16650	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C7K70_RS16655	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C7K70_RS16665	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C7K70_RS16670	COG0737	Belongs to the 5'-nucleotidase family
C7K70_RS16675	COG0193	aminoacyl-tRNA hydrolase activity
C7K70_RS16680	COG0012	GTP binding
C7K70_RS16725	COG0471	metal ion transport
C7K70_RS16725	COG0490	domain, Protein
C7K70_RS16745	COG3097	Belongs to the UPF0267 family
C7K70_RS16760	COG0443	Heat shock 70 kDa protein
C7K70_RS16770	COG0366	Alpha amylase catalytic
C7K70_RS16795	COG0674	pyruvate-flavodoxin oxidoreductase activity
C7K70_RS16795	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C7K70_RS16795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7K70_RS16795	COG1013	pyruvate-flavodoxin oxidoreductase activity
C7K70_RS16805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K70_RS16815	COG1012	belongs to the aldehyde dehydrogenase family
C7K70_RS16825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C7K70_RS16840	COG0180	Tryptophanyl-tRNA synthetase
C7K70_RS16850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C7K70_RS16855	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C7K70_RS16865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C7K70_RS16870	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C7K70_RS16900	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C7K70_RS16905	COG0583	DNA-binding transcription factor activity
C7K70_RS16925	COG0583	DNA-binding transcription factor activity
C7K70_RS16940	COG0739	heme binding
C7K70_RS16950	COG3264	Mechanosensitive ion channel
C7K70_RS16950	COG1511	domain protein
C7K70_RS16955	COG0584	glycerophosphoryl diester phosphodiesterase
C7K70_RS16965	COG1053	succinate dehydrogenase
C7K70_RS16970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C7K70_RS16975	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C7K70_RS17000	COG3214	Protein conserved in bacteria
C7K70_RS17040	COG0642	Histidine kinase
C7K70_RS17060	COG0516	GMP reductase activity
C7K70_RS17075	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C7K70_RS17080	COG3647	Membrane
C7K70_RS17090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7K70_RS17100	COG3706	GGDEF domain
C7K70_RS17110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K70_RS17120	COG0583	DNA-binding transcription factor activity
C7K70_RS17125	COG3706	GGDEF domain
C7K70_RS17130	COG1278	Cold shock
C7K70_RS17140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7K70_RS17145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C7K70_RS17150	COG1702	phosphate starvation-inducible protein PhoH
C7K70_RS17155	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C7K70_RS17160	COG4535	Mg2 and Co2 transporter CorC
C7K70_RS17165	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C7K70_RS17170	COG2888	peptidyl-tyrosine sulfation
C7K70_RS17175	COG0495	leucyl-tRNA aminoacylation
C7K70_RS17190	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C7K70_RS17195	COG0799	negative regulation of ribosome biogenesis
C7K70_RS17200	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C7K70_RS17205	COG0768	penicillin binding
C7K70_RS17210	COG0772	Belongs to the SEDS family
C7K70_RS17215	COG2951	lytic endotransglycosylase activity
C7K70_RS17225	COG1686	Belongs to the peptidase S11 family
C7K70_RS17230	COG2921	Belongs to the UPF0250 family
C7K70_RS17235	COG0321	lipoyl(octanoyl) transferase activity
C7K70_RS17245	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C7K70_RS17255	COG3545	Serine hydrolase
C7K70_RS17260	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C7K70_RS17275	COG0789	Transcriptional regulator
C7K70_RS17285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C7K70_RS17290	COG1970	mechanosensitive ion channel activity
C7K70_RS17295	COG4974	Belongs to the 'phage' integrase family
C7K70_RS17310	COG0312	modulator of DNA gyrase
C7K70_RS17315	COG0312	modulator of DNA gyrase
C7K70_RS17380	COG3275	phosphorelay sensor kinase activity
C7K70_RS17385	COG3279	Response regulator of the LytR AlgR family
C7K70_RS17390	COG1966	Carbon starvation protein
C7K70_RS17400	COG0114	fumarate hydratase activity
C7K70_RS17410	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C7K70_RS17420	COG2211	Major facilitator Superfamily
C7K70_RS17425	COG1185	polyribonucleotide nucleotidyltransferase activity
C7K70_RS17430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C7K70_RS17435	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C7K70_RS17440	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C7K70_RS17445	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C7K70_RS17450	COG0195	Participates in both transcription termination and antitermination
C7K70_RS17455	COG0779	Required for maturation of 30S ribosomal subunits
C7K70_RS17470	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C7K70_RS17475	COG0149	triose-phosphate isomerase activity
C7K70_RS17480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7K70_RS17485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C7K70_RS17495	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C7K70_RS17500	COG1534	Rna-binding protein
C7K70_RS17515	COG1360	Flagellar Motor Protein
C7K70_RS17520	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C7K70_RS17525	COG1722	exodeoxyribonuclease VII activity
C7K70_RS17530	COG0142	geranyltranstransferase activity
C7K70_RS17535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C7K70_RS17545	COG0601	transmembrane transport
C7K70_RS17555	COG4172	Belongs to the ABC transporter superfamily
C7K70_RS17560	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C7K70_RS17565	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C7K70_RS17570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7K70_RS17575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C7K70_RS17595	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C7K70_RS17595	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C7K70_RS17600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C7K70_RS17610	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C7K70_RS17620	COG3381	protein complex oligomerization
C7K70_RS17640	COG5001	Diguanylate cyclase
C7K70_RS17640	COG3300	MHYT domain
C7K70_RS17650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C7K70_RS17655	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C7K70_RS17660	COG0511	ligase activity, forming carbon-carbon bonds
C7K70_RS17665	COG0439	Biotin carboxylase
C7K70_RS17675	COG4145	pantothenate transmembrane transporter activity
C7K70_RS17680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K70_RS17680	COG2190	(PTS) system
C7K70_RS17680	COG1263	PTS System
C7K70_RS17685	COG0583	DNA-binding transcription factor activity
C7K70_RS17690	COG0604	alcohol dehydrogenase
C7K70_RS17700	COG2264	protein methyltransferase activity
C7K70_RS17715	COG0778	Nitroreductase
C7K70_RS17720	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7K70_RS17720	COG1902	pentaerythritol trinitrate reductase activity
C7K70_RS17725	COG0616	signal peptide processing
C7K70_RS17745	COG3139	Protein of unknown function (DUF1315)
C7K70_RS17750	COG0252	asparaginase activity
C7K70_RS17755	COG0786	glutamate:sodium symporter activity
C7K70_RS17770	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C7K70_RS17775	COG0384	phenazine biosynthesis protein PhzF
C7K70_RS17780	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C7K70_RS17785	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C7K70_RS17790	COG0175	sulfate reduction
C7K70_RS17800	COG2113	Glycine betaine
C7K70_RS17805	COG4176	ABC-type proline glycine betaine transport system permease component
C7K70_RS17810	COG4175	Glycine betaine
C7K70_RS17820	COG3610	response to peptide
C7K70_RS17825	COG2966	Psort location CytoplasmicMembrane, score
C7K70_RS17835	COG0521	Mo-molybdopterin cofactor biosynthetic process
C7K70_RS17850	COG1028	Short-chain dehydrogenase reductase Sdr
C7K70_RS17860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C7K70_RS17885	COG2986	histidine ammonia-lyase
C7K70_RS17910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7K70_RS17950	COG1858	cytochrome C peroxidase
C7K70_RS17960	COG2313	pseudouridylate synthase activity
C7K70_RS17965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7K70_RS17970	COG2146	nitrite reductase [NAD(P)H] activity
C7K70_RS17970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C7K70_RS17975	COG2146	nitrite reductase [NAD(P)H] activity
C7K70_RS17975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C7K70_RS17980	COG1116	anion transmembrane transporter activity
C7K70_RS17985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C7K70_RS17990	COG1116	anion transmembrane transporter activity
C7K70_RS17990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C7K70_RS18005	COG0243	molybdopterin cofactor binding
C7K70_RS18040	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C7K70_RS18055	COG1073	alpha beta
C7K70_RS18060	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C7K70_RS18075	COG2195	Cleaves the N-terminal amino acid of tripeptides
C7K70_RS18085	COG4608	Belongs to the ABC transporter superfamily
C7K70_RS18090	COG0444	Belongs to the ABC transporter superfamily
C7K70_RS18100	COG4239	(ABC) transporter, permease
C7K70_RS18105	COG4174	ABC transporter (Permease)
C7K70_RS18120	COG0811	peptide transport
C7K70_RS18125	COG0811	peptide transport
C7K70_RS18130	COG0848	biopolymer transport protein
C7K70_RS18180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7K70_RS18185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7K70_RS18190	COG0840	transmembrane signaling receptor activity
C7K70_RS18200	COG1278	Cold shock
C7K70_RS18240	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C7K70_RS18250	COG0688	phosphatidylethanolamine metabolic process
C7K70_RS18255	COG4628	conserved protein (DUF2132)
C7K70_RS18270	COG3059	membrane
C7K70_RS18275	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C7K70_RS18295	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C7K70_RS18365	COG1132	(ABC) transporter
C7K70_RS18375	COG1404	Belongs to the peptidase S8 family
C7K70_RS18380	COG2897	thiosulfate sulfurtransferase activity
C7K70_RS18385	COG2066	Belongs to the glutaminase family
C7K70_RS18390	COG3171	Protein conserved in bacteria
C7K70_RS18395	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C7K70_RS18400	COG4935	Belongs to the peptidase S8 family
C7K70_RS18400	COG2234	aminopeptidase activity
C7K70_RS18405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7K70_RS18410	COG2200	EAL domain
C7K70_RS18415	COG1090	epimerase
C7K70_RS18420	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C7K70_RS18425	COG4181	ATPase activity
C7K70_RS18430	COG2755	lipolytic protein G-D-S-L family
C7K70_RS18435	COG0784	Response regulator, receiver
C7K70_RS18435	COG0835	chemotaxis
C7K70_RS18445	COG0569	domain protein
C7K70_RS18445	COG2985	domain, Protein
C7K70_RS18450	COG1272	protein, Hemolysin III
C7K70_RS18455	COG0076	glutamate decarboxylase activity
C7K70_RS18460	COG2917	probably involved in intracellular septation
C7K70_RS18465	COG2350	Protein conserved in bacteria
C7K70_RS18475	COG1555	photosystem II stabilization
C7K70_RS18480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C7K70_RS18485	COG3104	oligopeptide transport
C7K70_RS18490	COG0745	RESPONSE REGULATOR receiver
C7K70_RS18520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7K70_RS18535	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C7K70_RS18540	COG1280	lysine exporter protein (LysE YggA)
C7K70_RS18570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7K70_RS18575	COG0564	pseudouridine synthase activity
C7K70_RS18585	COG3300	MHYT domain
C7K70_RS18585	COG5001	Diguanylate cyclase
C7K70_RS18595	COG0459	protein refolding
C7K70_RS18600	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C7K70_RS18605	COG0534	Mate efflux family protein
C7K70_RS18610	COG3030	protein affecting phage T7 exclusion by the F plasmid
C7K70_RS18615	COG1027	Aspartate ammonia-lyase
C7K70_RS18620	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C7K70_RS18630	COG0477	Major facilitator Superfamily
C7K70_RS18645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7K70_RS18650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7K70_RS18660	COG0673	inositol 2-dehydrogenase activity
C7K70_RS18670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C7K70_RS18675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C7K70_RS18680	COG3036	rescue of stalled ribosome
C7K70_RS18685	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C7K70_RS18695	COG0138	bifunctional purine biosynthesis protein purh
C7K70_RS18700	COG0151	Belongs to the GarS family
C7K70_RS18725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C7K70_RS18730	COG0358	DNA primase activity
C7K70_RS18735	COG1610	YqeY-like protein
C7K70_RS18740	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C7K70_RS18745	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C7K70_RS18760	COG1238	metal cluster binding
C7K70_RS18765	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C7K70_RS18770	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C7K70_RS18775	COG0585	pseudouridine synthase activity
C7K70_RS18785	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C7K70_RS18790	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C7K70_RS18795	COG0148	phosphopyruvate hydratase activity
C7K70_RS18800	COG0504	CTP synthase activity
C7K70_RS18805	COG3956	TIGRFAM MazG family protein
C7K70_RS18810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C7K70_RS18815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C7K70_RS18825	COG4807	Protein conserved in bacteria
C7K70_RS18830	COG3023	N-Acetylmuramoyl-L-alanine amidase
C7K70_RS18840	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C7K70_RS18845	COG1381	Involved in DNA repair and RecF pathway recombination
C7K70_RS18855	COG0571	ribonuclease III activity
C7K70_RS18860	COG0681	Belongs to the peptidase S26 family
C7K70_RS18865	COG0481	GTPase activity
C7K70_RS18880	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C7K70_RS18885	COG1595	DNA-templated transcription, initiation
C7K70_RS18890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C7K70_RS18900	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C7K70_RS18940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7K70_RS18950	COG0126	phosphoglycerate kinase activity
C7K70_RS18955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C7K70_RS18960	COG1940	carbohydrate kinase activity
C7K70_RS18965	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C7K70_RS18980	COG4991	sh3 domain protein
C7K70_RS18985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7K70_RS19000	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C7K70_RS19005	COG1028	Short-chain dehydrogenase reductase Sdr
C7K70_RS19015	COG2982	Protein involved in outer membrane biogenesis
C7K70_RS19020	COG1505	serine-type exopeptidase activity
C7K70_RS19025	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C7K70_RS19030	COG0765	amino acid transport
C7K70_RS19035	COG0765	amino acid transport
C7K70_RS19040	COG1126	abc transporter atp-binding protein
C7K70_RS19045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K70_RS19050	COG1136	(ABC) transporter
C7K70_RS19050	COG0577	efflux transmembrane transporter activity
C7K70_RS19055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7K70_RS19060	COG0745	RESPONSE REGULATOR receiver
C7K70_RS19065	COG2205	protein histidine kinase activity
C7K70_RS19070	COG2816	NAD+ diphosphatase activity
C7K70_RS19110	COG2070	2-Nitropropane dioxygenase
C7K70_RS19140	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
C7K70_RS19175	COG0513	Belongs to the DEAD box helicase family
C7K70_RS19195	COG0154	amidase activity
C7K70_RS19200	COG2957	Belongs to the agmatine deiminase family
C7K70_RS19215	COG1902	pentaerythritol trinitrate reductase activity
C7K70_RS19255	COG3300	MHYT domain
C7K70_RS19255	COG5001	Diguanylate cyclase
C7K70_RS19265	COG0714	Associated with various cellular activities
C7K70_RS19275	COG0456	acetyltransferase
C7K70_RS19285	COG1022	Amp-dependent synthetase and ligase
C7K70_RS19295	COG2918	glutathione biosynthetic process
C7K70_RS19300	COG0612	Peptidase, M16
C7K70_RS19305	COG1238	metal cluster binding
C7K70_RS19330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C7K70_RS19335	COG0359	binds to the 23S rRNA
C7K70_RS19340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C7K70_RS19345	COG0360	Binds together with S18 to 16S ribosomal RNA
C7K70_RS19350	COG1914	H( )-stimulated, divalent metal cation uptake system
C7K70_RS19370	COG2153	protein acetylation
C7K70_RS19380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7K70_RS19395	COG0557	exoribonuclease II activity
C7K70_RS19400	COG3706	GGDEF domain
C7K70_RS19405	COG1854	S-ribosylhomocysteine lyase activity
C7K70_RS19420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7K70_RS19420	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C7K70_RS19475	COG4970	Tfp pilus assembly protein FimT
C7K70_RS19480	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C7K70_RS19485	COG1047	Peptidyl-prolyl cis-trans
C7K70_RS19490	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C7K70_RS19495	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C7K70_RS19500	COG0196	riboflavin kinase activity
C7K70_RS19505	COG0728	peptidoglycan biosynthetic process
C7K70_RS19510	COG0268	Binds directly to 16S ribosomal RNA
C7K70_RS19515	COG0640	Transcriptional regulator
C7K70_RS19520	COG0583	DNA-binding transcription factor activity
C7K70_RS19530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C7K70_RS19535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C7K70_RS19540	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C7K70_RS19550	COG1051	belongs to the nudix hydrolase family
C7K70_RS19560	COG3066	DNA modification
C7K70_RS19570	COG0335	large ribosomal subunit rRNA binding
C7K70_RS19575	COG0336	Belongs to the RNA methyltransferase TrmD family
C7K70_RS19580	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C7K70_RS19585	COG0228	four-way junction DNA binding
C7K70_RS19590	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C7K70_RS19595	COG4137	Cytochrome C assembly protein
C7K70_RS19600	COG4536	flavin adenine dinucleotide binding
C7K70_RS19610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C7K70_RS19610	COG1017	nitric oxide dioxygenase activity
C7K70_RS19615	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C7K70_RS19620	COG0039	L-malate dehydrogenase activity
C7K70_RS19625	COG4160	amino acid transport
C7K70_RS19630	COG4215	(ABC) transporter
C7K70_RS19635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K70_RS19640	COG1126	abc transporter atp-binding protein
C7K70_RS19645	COG1438	arginine binding
C7K70_RS19650	COG2837	iron assimilation
C7K70_RS19655	COG3842	ATPase activity
C7K70_RS19665	COG1840	ABC-type Fe3 transport system, periplasmic component
C7K70_RS19670	COG0347	Belongs to the P(II) protein family
C7K70_RS19685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C7K70_RS19690	COG0583	DNA-binding transcription factor activity
C7K70_RS19705	COG1929	Belongs to the glycerate kinase type-1 family
C7K70_RS19710	COG2610	gluconate transmembrane transporter activity
C7K70_RS19715	COG3835	regulator
C7K70_RS19720	COG3112	Uncharacterised protein family (UPF0231)
C7K70_RS19735	COG0840	transmembrane signaling receptor activity
C7K70_RS19755	COG0513	Belongs to the DEAD box helicase family
C7K70_RS19795	COG1448	Aminotransferase
C7K70_RS19810	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C7K70_RS19815	COG1328	CTP reductase activity
C7K70_RS19835	COG4946	Tricorn protease homolog
C7K70_RS19835	COG0793	Belongs to the peptidase S41A family
C7K70_RS19875	COG0840	transmembrane signaling receptor activity
C7K70_RS19880	COG3397	chitin binding
C7K70_RS19885	COG0583	DNA-binding transcription factor activity
C7K70_RS19895	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C7K70_RS19900	COG4208	sulfate ABC transporter
C7K70_RS19905	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C7K70_RS19915	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C7K70_RS19920	COG3174	membrane
C7K70_RS19925	COG0110	maltose O-acetyltransferase activity
C7K70_RS19950	COG0165	Argininosuccinate lyase
C7K70_RS19960	COG0137	argininosuccinate synthase activity
C7K70_RS19970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C7K70_RS19975	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C7K70_RS19985	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C7K70_RS19990	COG0460	homoserine dehydrogenase
C7K70_RS19990	COG0527	aspartate kinase activity
C7K70_RS19995	COG0626	cystathionine gamma-synthase activity
C7K70_RS20005	COG3708	Transcriptional regulator
C7K70_RS20005	COG2207	Transcriptional regulator
C7K70_RS20010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K70_RS20015	COG0814	amino acid
C7K70_RS20020	COG1218	3'(2'),5'-bisphosphate nucleotidase
C7K70_RS20025	COG0494	nUDIX hydrolase
C7K70_RS20030	COG1011	Hydrolase
C7K70_RS20035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C7K70_RS20050	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C7K70_RS20060	COG3156	type II secretion system protein K
C7K70_RS20075	COG4795	General secretion pathway protein
C7K70_RS20080	COG2165	general secretion pathway protein
C7K70_RS20090	COG2165	general secretion pathway protein
C7K70_RS20095	COG1459	type II secretion system
C7K70_RS20100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7K70_RS20110	COG3031	protein transport across the cell outer membrane
C7K70_RS20120	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C7K70_RS20125	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C7K70_RS20145	COG0456	acetyltransferase
C7K70_RS20150	COG3133	Outer membrane lipoprotein
C7K70_RS20165	COG2771	luxR family
C7K70_RS20170	COG3916	Acyl-homoserine-lactone synthase
C7K70_RS20180	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C7K70_RS20185	COG1309	transcriptional regulator
C7K70_RS20195	COG2213	PTS system mannitol-specific
C7K70_RS20195	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K70_RS20200	COG0246	Mannitol dehydrogenase
C7K70_RS20205	COG3722	fumarate hydratase activity
C7K70_RS20210	COG3263	regulation of cellular component size
C7K70_RS20235	COG1671	Belongs to the UPF0178 family
C7K70_RS20250	COG1988	membrane-bound metal-dependent
C7K70_RS20255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C7K70_RS20260	COG0513	Belongs to the DEAD box helicase family
C7K70_RS20290	COG1575	Belongs to the MenA family. Type 1 subfamily
C7K70_RS20295	COG1169	isochorismate synthase
C7K70_RS20300	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C7K70_RS20305	COG0596	Alpha beta hydrolase
C7K70_RS20310	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C7K70_RS20315	COG1441	menaquinone biosynthetic process
C7K70_RS20320	COG0318	PFAM AMP-dependent synthetase and ligase
C7K70_RS20335	COG3539	Fimbrial protein
C7K70_RS20345	COG3188	usher protein
C7K70_RS20355	COG3539	Fimbrial protein
C7K70_RS20365	COG3291	Pkd domain containing protein
C7K70_RS20370	COG2949	membrane
C7K70_RS20390	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C7K70_RS20395	COG5380	lipid catabolic process
C7K70_RS20410	COG4533	DNA binding
C7K70_RS20420	COG2873	o-acetylhomoserine
C7K70_RS20430	COG1979	alcohol dehydrogenase
C7K70_RS20450	COG4221	oxidoreductase activity
C7K70_RS20470	COG1285	pathogenesis
C7K70_RS20490	COG1368	sulfuric ester hydrolase activity
C7K70_RS20495	COG1522	sequence-specific DNA binding
C7K70_RS20505	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C7K70_RS20510	COG1418	mRNA catabolic process
C7K70_RS20515	COG1058	Belongs to the CinA family
C7K70_RS20515	COG1546	Belongs to the CinA family
C7K70_RS20525	COG0842	Transport permease protein
C7K70_RS20525	COG1129	ABC transporter
C7K70_RS20540	COG0561	phosphatase activity
C7K70_RS20545	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C7K70_RS20565	COG1011	Hydrolase
C7K70_RS20580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C7K70_RS20585	COG0019	diaminopimelate decarboxylase activity
C7K70_RS20595	COG1965	Belongs to the frataxin family
C7K70_RS20605	COG3072	Adenylate cyclase
C7K70_RS20610	COG0181	hydroxymethylbilane synthase activity
C7K70_RS20620	COG2959	enzyme of heme biosynthesis
C7K70_RS20635	COG1494	fructose-1,6-bisphosphatase
C7K70_RS20675	COG1733	regulation of RNA biosynthetic process
C7K70_RS20695	COG3932	Exopolysaccharide synthesis, ExoD
C7K70_RS20700	COG0814	amino acid
C7K70_RS20705	COG3706	GGDEF domain
C7K70_RS20720	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
C7K70_RS20740	COG2856	Zn peptidase
C7K70_RS20750	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C7K70_RS20755	COG2022	thiamine diphosphate biosynthetic process
C7K70_RS20765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C7K70_RS20770	COG0352	thiamine-phosphate diphosphorylase activity
C7K70_RS20775	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C7K70_RS20780	COG0754	glutathionylspermidine amidase activity
C7K70_RS20790	COG3766	membrane
C7K70_RS20805	COG0745	RESPONSE REGULATOR receiver
C7K70_RS20810	COG0642	Histidine kinase
C7K70_RS20820	COG0189	ligase activity
C7K70_RS20845	COG1639	'signal transduction protein
C7K70_RS20855	COG2321	neutral zinc metallopeptidase
C7K70_RS20860	COG3700	Belongs to the class B bacterial acid phosphatase family
C7K70_RS20880	COG1366	Belongs to the anti-sigma-factor antagonist family
C7K70_RS20885	COG2172	sigma factor antagonist activity
C7K70_RS20890	COG5002	protein histidine kinase activity
C7K70_RS20890	COG2205	protein histidine kinase activity
C7K70_RS20890	COG0784	Response regulator, receiver
C7K70_RS20895	COG3437	response regulator, receiver
C7K70_RS20905	COG0477	Major facilitator Superfamily
C7K70_RS20920	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C7K70_RS20925	COG1263	PTS System
C7K70_RS20925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K70_RS20945	COG0312	modulator of DNA gyrase
C7K70_RS20950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7K70_RS20965	COG3164	Protein of unknown function
C7K70_RS20970	COG1530	ribonuclease E activity
C7K70_RS20975	COG0424	maF-like protein
C7K70_RS20980	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C7K70_RS20985	COG1792	Involved in formation and maintenance of cell shape
C7K70_RS20990	COG1077	Cell shape determining protein MreB Mrl
C7K70_RS21015	COG4968	Prepilin-type N-terminal cleavage methylation domain
C7K70_RS21020	COG2165	general secretion pathway protein
C7K70_RS21025	COG2165	general secretion pathway protein
C7K70_RS21035	COG1459	type II secretion system
C7K70_RS21040	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7K70_RS21090	COG2200	EAL domain
C7K70_RS21090	COG2199	diguanylate cyclase activity
C7K70_RS21095	COG2200	EAL domain
C7K70_RS21100	COG0387	Pfam Sodium calcium exchanger
C7K70_RS21105	COG2986	histidine ammonia-lyase
C7K70_RS21110	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C7K70_RS21115	COG0010	Belongs to the arginase family
C7K70_RS21120	COG1228	amidohydrolase
C7K70_RS21125	COG2188	Transcriptional regulator
C7K70_RS21130	COG0288	reversible hydration of carbon dioxide
C7K70_RS21140	COG2177	Part of the ABC transporter FtsEX involved in
C7K70_RS21145	COG2884	Cell division ATP-binding protein ftsE
C7K70_RS21150	COG0552	protein localization to endoplasmic reticulum
C7K70_RS21155	COG0742	ribosomal rna small subunit methyltransferase
C7K70_RS21185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C7K70_RS21190	COG0741	lytic transglycosylase activity
C7K70_RS21200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C7K70_RS21210	COG2095	MarC family integral membrane protein
C7K70_RS21220	COG1301	dicarboxylic acid transport
C7K70_RS21245	COG3714	YhhN family
C7K70_RS21270	COG1770	oligopeptidase
C7K70_RS21285	COG4221	oxidoreductase activity
C7K70_RS21290	COG0583	DNA-binding transcription factor activity
C7K70_RS21295	COG2249	NAD(P)H dehydrogenase (quinone) activity
C7K70_RS21355	COG0203	ribosomal protein L17
C7K70_RS21360	COG0202	RNA polymerase activity
C7K70_RS21365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C7K70_RS21370	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C7K70_RS21375	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C7K70_RS21380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C7K70_RS21385	COG0201	protein transport
C7K70_RS21390	COG0200	Binds to the 23S rRNA
C7K70_RS21395	COG1841	ribosomal large subunit assembly
C7K70_RS21400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C7K70_RS21405	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C7K70_RS21410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C7K70_RS21415	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C7K70_RS21420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C7K70_RS21425	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C7K70_RS21430	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C7K70_RS21435	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C7K70_RS21440	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C7K70_RS21445	COG0255	Belongs to the universal ribosomal protein uL29 family
C7K70_RS21450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C7K70_RS21455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C7K70_RS21460	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C7K70_RS21465	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C7K70_RS21470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C7K70_RS21475	COG0089	rRNA binding
C7K70_RS21480	COG0088	Forms part of the polypeptide exit tunnel
C7K70_RS21485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C7K70_RS21490	COG0051	transcription antitermination factor activity, RNA binding
C7K70_RS21510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7K70_RS21515	COG2183	response to ionizing radiation
C7K70_RS21535	COG0596	Alpha beta hydrolase
C7K70_RS21540	COG1040	competence protein
C7K70_RS21545	COG0316	Belongs to the HesB IscA family
C7K70_RS21545	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C7K70_RS21550	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C7K70_RS21555	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C7K70_RS21560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7K70_RS21565	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C7K70_RS21570	COG4942	peptidase
C7K70_RS21580	COG1609	Transcriptional regulator
C7K70_RS21585	COG0800	Aldolase
C7K70_RS21595	COG3265	gluconokinase activity
C7K70_RS21600	COG2610	gluconate transmembrane transporter activity
C7K70_RS21605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C7K70_RS21610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C7K70_RS21620	COG0456	acetyltransferase
C7K70_RS21630	COG1490	D-aminoacyl-tRNA deacylase activity
C7K70_RS21635	COG1295	ribonuclease BN
C7K70_RS21640	COG1217	gtp-binding protein TYPA
C7K70_RS21645	COG0174	glutamine synthetase
C7K70_RS21655	COG3852	Histidine kinase
C7K70_RS21660	COG2204	response regulator
C7K70_RS21665	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C7K70_RS21670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C7K70_RS21680	COG3078	GTPase activator activity
C7K70_RS21695	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C7K70_RS21705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C7K70_RS21710	COG0408	coproporphyrinogen oxidase activity
C7K70_RS21715	COG0009	L-threonylcarbamoyladenylate synthase
C7K70_RS21725	COG0551	DNA topoisomerase type I activity
C7K70_RS21730	COG2922	Belongs to the Smg family
C7K70_RS21735	COG0758	DNA mediated transformation
C7K70_RS21745	COG0242	peptide deformylase activity
C7K70_RS21750	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C7K70_RS21755	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C7K70_RS21755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7K70_RS21760	COG0569	domain protein
C7K70_RS21765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C7K70_RS21770	COG1322	Protein conserved in bacteria
C7K70_RS21790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7K70_RS21795	COG0686	Belongs to the AlaDH PNT family
C7K70_RS21800	COG0519	Catalyzes the synthesis of GMP from XMP
C7K70_RS21800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C7K70_RS21810	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C7K70_RS21815	COG1396	sequence-specific DNA binding
C7K70_RS21820	COG1012	belongs to the aldehyde dehydrogenase family
C7K70_RS21830	COG2962	Rard protein
C7K70_RS21840	COG1280	lysine exporter protein (LysE YggA)
C7K70_RS21850	COG2391	methyltransferase activity
C7K70_RS21860	COG1280	lysine exporter protein (LysE YggA)
C7K70_RS21920	COG0210	DNA helicase
C7K70_RS21935	COG1744	ABC transporter substrate-binding protein PnrA-like
C7K70_RS21940	COG3845	ABC transporter
C7K70_RS21945	COG4603	Belongs to the binding-protein-dependent transport system permease family
C7K70_RS21950	COG1079	Belongs to the binding-protein-dependent transport system permease family
C7K70_RS21955	COG0583	DNA-binding transcription factor activity
C7K70_RS21975	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C7K70_RS21980	COG0385	Bile acid
C7K70_RS21985	COG0531	amino acid
C7K70_RS21990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K70_RS21995	COG0531	amino acid
C7K70_RS22000	COG2731	YhcH YjgK YiaL family protein
C7K70_RS22005	COG3250	beta-galactosidase activity
C7K70_RS22010	COG1609	Transcriptional regulator
C7K70_RS22045	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C7K70_RS22050	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K70_RS22050	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K70_RS22055	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C7K70_RS22060	COG3074	FtsZ-dependent cytokinesis
C7K70_RS22070	COG1045	serine acetyltransferase
C7K70_RS22080	COG0745	RESPONSE REGULATOR receiver
C7K70_RS22085	COG2205	protein histidine kinase activity
C7K70_RS22090	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C7K70_RS22095	COG0534	Mate efflux family protein
C7K70_RS22120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C7K70_RS22125	COG2937	Belongs to the GPAT DAPAT family
C7K70_RS22130	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C7K70_RS22135	COG3161	chorismate lyase activity
C7K70_RS22140	COG1580	Controls the rotational direction of flagella during chemotaxis
C7K70_RS22160	COG0604	alcohol dehydrogenase
C7K70_RS22165	COG1609	Transcriptional regulator
C7K70_RS22185	COG1519	Transferase
C7K70_RS22190	COG0859	PFAM glycosyl transferase family 9
C7K70_RS22195	COG0463	Glycosyl transferase, family 2
C7K70_RS22200	COG0859	PFAM glycosyl transferase family 9
C7K70_RS22205	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C7K70_RS22210	COG2990	Protein conserved in bacteria
C7K70_RS22215	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C7K70_RS22225	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7K70_RS22230	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C7K70_RS22235	COG2003	Belongs to the UPF0758 family
C7K70_RS22240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C7K70_RS22245	COG0756	dUTP diphosphatase activity
C7K70_RS22250	COG1309	transcriptional regulator
C7K70_RS22255	COG0668	transmembrane transport
C7K70_RS22270	COG0166	Belongs to the GPI family
C7K70_RS22275	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C7K70_RS22280	COG0583	DNA-binding transcription factor activity
C7K70_RS22295	COG1042	CoA-binding domain protein
C7K70_RS22295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7K70_RS22295	COG0045	succinate-CoA ligase (ADP-forming) activity
C7K70_RS22325	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C7K70_RS22335	COG0583	DNA-binding transcription factor activity
C7K70_RS22350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C7K70_RS22355	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C7K70_RS22360	COG2223	nitrite transmembrane transporter activity
C7K70_RS22365	COG3279	Response regulator of the LytR AlgR family
C7K70_RS22370	COG3275	phosphorelay sensor kinase activity
C7K70_RS22380	COG2223	nitrite transmembrane transporter activity
C7K70_RS22385	COG2081	HI0933 family
C7K70_RS22390	COG1528	Iron-storage protein
C7K70_RS22400	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C7K70_RS22405	COG0589	response to stress
C7K70_RS22445	COG3642	lipopolysaccharide core region biosynthetic process
C7K70_RS22450	COG0859	PFAM glycosyl transferase family 9
C7K70_RS22460	COG1758	RNA polymerase activity
C7K70_RS22465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C7K70_RS22470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7K70_RS22475	COG2267	carboxylic ester hydrolase activity
C7K70_RS22480	COG0561	phosphatase activity
C7K70_RS22505	COG2271	Major facilitator Superfamily
C7K70_RS22510	COG0469	pyruvate kinase activity
C7K70_RS22540	COG1309	transcriptional regulator
C7K70_RS22545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7K70_RS22550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7K70_RS22555	COG4191	Histidine kinase
C7K70_RS22555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K70_RS22560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7K70_RS22585	COG2205	protein histidine kinase activity
C7K70_RS22590	COG0745	RESPONSE REGULATOR receiver
C7K70_RS22595	COG2814	Major facilitator Superfamily
C7K70_RS22610	COG3977	Valine--pyruvate aminotransferase
C7K70_RS22615	COG0071	Belongs to the small heat shock protein (HSP20) family
C7K70_RS22620	COG0071	Belongs to the small heat shock protein (HSP20) family
C7K70_RS22625	COG2378	regulation of single-species biofilm formation
C7K70_RS22640	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C7K70_RS22645	COG0592	DNA-directed DNA polymerase activity
C7K70_RS22650	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C7K70_RS22665	COG1126	abc transporter atp-binding protein
C7K70_RS22670	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C7K70_RS22675	COG0594	ribonuclease P activity
C7K70_RS22680	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C7K70_RS22685	COG0706	membrane insertase activity
C7K70_RS22690	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C7K70_RS22705	COG1120	ATPase activity
C7K70_RS22710	COG4615	Cyclic peptide transporter
C7K70_RS22715	COG4774	siderophore transport
C7K70_RS22720	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C7K70_RS22725	COG0445	tRNA wobble uridine modification
C7K70_RS22730	COG0357	Ribosomal RNA small subunit methyltransferase G
C7K70_RS22735	COG1192	Involved in chromosome partitioning
C7K70_RS22740	COG1475	DNA binding
C7K70_RS22750	COG0356	it plays a direct role in the translocation of protons across the membrane
C7K70_RS22760	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C7K70_RS22765	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7K70_RS22770	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C7K70_RS22775	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C7K70_RS22780	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C7K70_RS22785	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C7K70_RS22790	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C7K70_RS22795	COG4452	Inner membrane protein CreD
C7K70_RS22805	COG2205	protein histidine kinase activity
C7K70_RS22810	COG0745	RESPONSE REGULATOR receiver
C7K70_RS22815	COG1349	DNA-binding transcription factor activity
C7K70_RS22820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C7K70_RS22825	COG2771	luxR family
C7K70_RS22835	COG0811	peptide transport
C7K70_RS22840	COG0811	peptide transport
C7K70_RS22845	COG0848	biopolymer transport protein
C7K70_RS22850	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C7K70_RS22900	COG0402	S-adenosylhomocysteine deaminase activity
C7K70_RS22905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C7K70_RS22915	COG3165	ubiquinone biosynthetic process from chorismate
C7K70_RS22920	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C7K70_RS22930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C7K70_RS22935	COG0805	protein transport
C7K70_RS22940	COG0084	hydrolase, TatD family'
C7K70_RS22960	COG0742	ribosomal rna small subunit methyltransferase
C7K70_RS22975	COG0248	Ppx GppA phosphatase
C7K70_RS22980	COG0513	Belongs to the DEAD box helicase family
C7K70_RS22985	COG3118	belongs to the thioredoxin family
C7K70_RS23000	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C7K70_RS23025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7K70_RS23065	COG1609	Transcriptional regulator
C7K70_RS23080	COG2188	Transcriptional regulator
C7K70_RS23085	COG3604	Transcriptional regulator
C7K70_RS23090	COG0426	domain, Protein
C7K70_RS23090	COG1773	rubredoxin
C7K70_RS23095	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7K70_RS23105	COG0348	domain, Protein
C7K70_RS23110	COG0814	amino acid
C7K70_RS23145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate