locus-tag	class	description
HFP99_RS00010	ENOG4107V4F	S-adenosyl-l-methionine hydroxide adenosyltransferase
HFP99_RS00040	ENOG4107QWG	2-Nitropropane dioxygenase
HFP99_RS00070	ENOG4108NIW	Leucine export protein LeuE
HFP99_RS00125	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
HFP99_RS00130	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HFP99_RS00170	ENOG4105I93	response regulator
HFP99_RS00175	ENOG4105DUX	Transporter
HFP99_RS00180	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HFP99_RS00185	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
HFP99_RS00190	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
HFP99_RS00195	ENOG4105K9H	YciI-like protein
HFP99_RS00200	ENOG4107835	probably involved in intracellular septation (By similarity)
HFP99_RS00205	ENOG4105DY8	decarboxylase
HFP99_RS00210	ENOG4108UT2	hemolysin iii
HFP99_RS00215	ENOG4105D0C	transport protein
HFP99_RS00245	ENOG4105EV4	Multidrug resistance protein mdtH
HFP99_RS00265	ENOG4105D9U	N-acetyltransferase
HFP99_RS00275	ENOG4105XEP	YhcH YjgK YiaL family protein
HFP99_RS00285	ENOG4105CUY	Mechanosensitive ion channel
HFP99_RS00290	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
HFP99_RS00295	ENOG4105CK7	Sodium proline symporter
HFP99_RS00310	ENOG4108Z6Z	Transcriptional regulator
HFP99_RS00335	ENOG4105D6S	protein involved in catabolism of external DNA
HFP99_RS00345	ENOG4105C5H	ABC transporter
HFP99_RS00350	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HFP99_RS00355	ENOG4105FCK	Membrane
HFP99_RS00365	ENOG4108UJV	acyl-CoA thioesterase i
HFP99_RS00370	ENOG4108I0Y	(ABC) transporter
HFP99_RS00375	ENOG4105CV6	ABC transporter, permease
HFP99_RS00380	ENOG4105ECP	epimerase
HFP99_RS00385	ENOG4105BZU	Histidine kinase
HFP99_RS00390	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HFP99_RS00395	ENOG4105IIU	Aminopeptidase
HFP99_RS00400	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HFP99_RS00405	ENOG41090ED	Protein with unknown function (DUF469)
HFP99_RS00410	ENOG4105CSV	Glutaminase
HFP99_RS00415	ENOG4107RM6	sulfurtransferase
HFP99_RS00420	ENOG4105E3R	(LipO)protein
HFP99_RS00425	ENOG4108W78	Pfam:DUF1017
HFP99_RS00430	ENOG4108MDC	(LipO)protein
HFP99_RS00450	ENOG4105SUV	lipoprotein YgdR
HFP99_RS00480	ENOG4105KQT	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity)
HFP99_RS00485	ENOG4105BZU	Histidine kinase
HFP99_RS00505	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
HFP99_RS00510	ENOG4105DJ4	phosphatidylserine decarboxylase
HFP99_RS00520	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HFP99_RS00560	ENOG4105VEQ	Cold shock protein
HFP99_RS00570	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_RS00575	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HFP99_RS00625	ENOG4109015	Biopolymer transport protein exbD tolR
HFP99_RS00650	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
HFP99_RS00655	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
HFP99_RS00670	ENOG4108JQ7	(ABC) transporter
HFP99_RS00675	ENOG4105CIN	aminoacyl-histidine dipeptidase
HFP99_RS00680	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
HFP99_RS00685	ENOG4105V1F	Fermentation respiration switch protein
HFP99_RS00690	ENOG4108UVK	Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity)
HFP99_RS00700	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HFP99_RS00750	ENOG4105D7T	ABC transporter
HFP99_RS00755	ENOG4107QZF	nitrite reductase NADPH large subunit
HFP99_RS00760	ENOG4107QZF	nitrite reductase NADPH large subunit
HFP99_RS00770	ENOG4105DD7	kinase (PfkB family
HFP99_RS00775	ENOG4105D53	Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity)
HFP99_RS00785	ENOG4105CA0	peroxidase
HFP99_RS00800	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HFP99_RS00810	ENOG4105DWK	Membrane
HFP99_RS00815	ENOG4107XM3	UPF0442 protein
HFP99_RS00825	ENOG4108IJ7	Glycine betaine
HFP99_RS00830	ENOG4108HQS	Glycine betaine
HFP99_RS00840	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
HFP99_RS00845	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
HFP99_RS00850	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HFP99_RS00855	ENOG4107TIF	Phenazine biosynthesis protein, PhzF family
HFP99_RS00860	ENOG4105CRK	lysyL-tRNA synthetase
HFP99_RS00870	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_RS00875	ENOG4105D6U	Sodium Glutamate Symporter
HFP99_RS00880	ENOG4105HDK	L-asparaginase
HFP99_RS00885	ENOG4105VUT	cytoplasmic protein
HFP99_RS00905	ENOG4105D07	Signal peptide peptidase, SppA
HFP99_RS00910	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HFP99_RS00915	ENOG41069NU	Nitroreductase
HFP99_RS00925	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HFP99_RS00930	ENOG4105CIS	alcohol dehydrogenase
HFP99_RS00935	ENOG4105HEI	LysR family (Transcriptional regulator
HFP99_RS00940	ENOG4105CI1	PTS System
HFP99_RS00945	ENOG4108IA2	Sodium pantothenate symporter
HFP99_RS00950	ENOG4105RG0	Membrane
HFP99_RS00955	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HFP99_RS00960	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HFP99_RS00965	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HFP99_RS00970	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HFP99_RS00985	ENOG4109039	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
HFP99_RS00990	ENOG4108EM1	reductase
HFP99_RS00995	ENOG4105CUW	cytochrome C-TYPE protein
HFP99_RS01000	ENOG4106WF9	DNA-binding transcriptional regulator TorR
HFP99_RS01010	ENOG4105BZU	Histidine kinase
HFP99_RS01020	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HFP99_RS01030	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HFP99_RS01035	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HFP99_RS01050	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HFP99_RS01055	ENOG4107YIM	Involved in the transcription termination process (By similarity)
HFP99_RS01060	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HFP99_RS01065	ENOG4108ZAI	phosphatidylglycerophosphatase a
HFP99_RS01070	ENOG4108JQ6	ABC transporter
HFP99_RS01080	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HFP99_RS01090	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HFP99_RS01095	ENOG4105CTB	Polyprenyl synthetase
HFP99_RS01100	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HFP99_RS01105	ENOG4105E14	MotA TolQ exbB proton channel
HFP99_RS01110	ENOG4107XSU	flagellar motor protein motb
HFP99_RS01120	ENOG4105CY3	ABC transporter, permease
HFP99_RS01125	ENOG4108IJ6	ABC transporter
HFP99_RS01145	ENOG4105T2N	Domain of unknown function (DUF2382)
HFP99_RS01150	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HFP99_RS01160	ENOG4105HBR	Rna-binding protein
HFP99_RS01165	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HFP99_RS01170	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HFP99_RS01175	ENOG4105EEI	dihydropteroate synthase
HFP99_RS01180	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HFP99_RS01185	ENOG4105CP7	Triose-phosphate isomerase
HFP99_RS01190	ENOG4105NTZ	Preprotein translocase subunit SecG
HFP99_RS01205	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HFP99_RS01210	ENOG4105CHV	Transcription elongation factor NusA
HFP99_RS01215	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HFP99_RS01220	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HFP99_RS01225	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HFP99_RS01230	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HFP99_RS01235	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HFP99_RS01240	ENOG4105E5W	Transporter
HFP99_RS01245	ENOG41090EX	DsrE family
HFP99_RS01250	ENOG4105WAY	exported protein
HFP99_RS01255	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
HFP99_RS01260	ENOG4105CFP	Peptidase U32
HFP99_RS01265	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
HFP99_RS01280	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HFP99_RS01285	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
HFP99_RS01290	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HFP99_RS01305	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HFP99_RS01325	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HFP99_RS01335	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HFP99_RS01340	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HFP99_RS01345	ENOG4108Z43	UPF0250 protein
HFP99_RS01350	ENOG4105DZ1	carboxypeptidase
HFP99_RS01355	ENOG4105K6T	rare lipoprotein A
HFP99_RS01360	ENOG4105CVE	Lytic murein transglycosylase
HFP99_RS01365	ENOG4105CNI	cell division protein FtsW
HFP99_RS01370	ENOG4105CNI	cell division protein FtsW
HFP99_RS01375	ENOG4105CJN	penicillin-binding protein
HFP99_RS01380	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HFP99_RS01385	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HFP99_RS01390	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HFP99_RS01405	ENOG4105C8T	Leucyl-tRNA synthetase
HFP99_RS01410	ENOG4107PAI	alpha helical protein
HFP99_RS01415	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HFP99_RS01420	ENOG4108JU5	Magnesium and cobalt efflux protein
HFP99_RS01430	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HFP99_RS01435	ENOG4105C9A	Phoh family
HFP99_RS01440	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HFP99_RS01445	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HFP99_RS01455	ENOG4105F04	LysR family Transcriptional regulator
HFP99_RS01465	ENOG4105EVE	HAD-superfamily hydrolase subfamily IA variant 3
HFP99_RS01475	ENOG4105BZU	Histidine kinase
HFP99_RS01485	ENOG4105C5I	Dehydrogenase
HFP99_RS01495	ENOG4108R5S	membrane
HFP99_RS01500	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HFP99_RS01510	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HFP99_RS01520	ENOG4105DHQ	Histidine kinase
HFP99_RS01525	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HFP99_RS01535	ENOG4108IXY	short-chain dehydrogenase reductase
HFP99_RS01545	ENOG4108IQE	Amp-dependent synthetase and ligase
HFP99_RS01555	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
HFP99_RS01560	ENOG4105T0Z	Conserved Protein
HFP99_RS01565	ENOG4108VP9	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
HFP99_RS01570	ENOG4108WJH	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
HFP99_RS01575	ENOG4105E33	succinate dehydrogenase
HFP99_RS01585	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_RS01590	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HFP99_RS01595	ENOG4105EGS	Mechanosensitive ion channel
HFP99_RS01605	ENOG4105DR5	peptidase
HFP99_RS01615	ENOG4108VEV	chaperone
HFP99_RS01625	ENOG4108VEV	chaperone
HFP99_RS01640	ENOG4105EJC	lysr family transcriptional regulator
HFP99_RS01655	ENOG4105C5Q	Transcriptional regulator
HFP99_RS01660	ENOG4108JQC	penicillin-binding protein 1A
HFP99_RS01685	ENOG4105E4G	Type IV pilus
HFP99_RS01690	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HFP99_RS01695	ENOG4105D49	3-dehydroquinate synthase
HFP99_RS01705	ENOG4105DFE	Dna adenine methylase
HFP99_RS01710	ENOG4105DJV	ribulose-phosphate 3-epimerase
HFP99_RS01715	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HFP99_RS01720	ENOG4105C31	Tryptophanyl-tRNA synthetase
HFP99_RS01735	ENOG4105C8Y	Acetylornithine aminotransferase
HFP99_RS01740	ENOG4105F4X	arginine
HFP99_RS01745	ENOG4105C26	Dehydrogenase
HFP99_RS01755	ENOG4107VXZ	Hydrolase
HFP99_RS01765	ENOG4107QF7	multi-drug
HFP99_RS01770	ENOG4105C5H	ABC transporter
HFP99_RS01780	ENOG4105CG3	alpha amylase, catalytic region
HFP99_RS01795	ENOG4105N5Z	UPF0267 protein
HFP99_RS01800	ENOG4107QWE	)-transporter
HFP99_RS01845	ENOG4105C3G	gtp-binding protein
HFP99_RS01855	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HFP99_RS01860	ENOG4105CGH	5'-nucleotidase
HFP99_RS01865	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HFP99_RS01875	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HFP99_RS01880	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
HFP99_RS01885	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HFP99_RS01890	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HFP99_RS01895	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HFP99_RS01905	ENOG41063JG	Transcriptional regulator
HFP99_RS01910	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HFP99_RS01915	ENOG4105CK2	sodium dicarboxylate symporter
HFP99_RS01920	ENOG4108VKA	Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity)
HFP99_RS01940	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HFP99_RS01945	ENOG4105BZG	amino acid carrier protein
HFP99_RS01960	ENOG4105G2Y	Transcriptional regulator
HFP99_RS01965	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HFP99_RS01975	ENOG4105D7Z	glutathione synthase
HFP99_RS01980	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HFP99_RS01990	ENOG4105GPY	SprT protein
HFP99_RS01995	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HFP99_RS02000	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HFP99_RS02010	ENOG4105KME	endoribonuclease L-psp
HFP99_RS02015	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
HFP99_RS02025	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
HFP99_RS02030	ENOG4105DR5	peptidase
HFP99_RS02035	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HFP99_RS02040	ENOG4107WCA	isomerase
HFP99_RS02055	ENOG4105DFH	Transport of potassium into the cell (By similarity)
HFP99_RS02085	ENOG4105XIQ	Protein of unknown function (DUF2517)
HFP99_RS02090	ENOG4105BZU	Histidine kinase
HFP99_RS02095	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
HFP99_RS02100	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HFP99_RS02120	ENOG4105CUB	amino acid
HFP99_RS02125	ENOG4105CUB	amino acid
HFP99_RS02130	ENOG4108JPW	Aminotransferase
HFP99_RS02135	ENOG4105C26	Dehydrogenase
HFP99_RS02140	ENOG4107VRI	Transcriptional regulator
HFP99_RS02145	ENOG4105CJP	fad dependent oxidoreductase
HFP99_RS02185	ENOG4108UJV	acyl-CoA thioesterase i
HFP99_RS02190	ENOG4105DH7	May be involved in recombination (By similarity)
HFP99_RS02195	ENOG4105K5X	acetyltransferase
HFP99_RS02200	ENOG4107RH8	nuclease SbcCD subunit D
HFP99_RS02205	ENOG4105EYH	Exonuclease
HFP99_RS02210	ENOG4105CPW	cytochrome b561
HFP99_RS02215	ENOG4105C5Y	PTS System
HFP99_RS02220	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HFP99_RS02225	ENOG4105KZ7	phosphocarrier protein hpr
HFP99_RS02230	ENOG4105C6T	cysteine synthase
HFP99_RS02235	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HFP99_RS02255	ENOG4108R96	Methyltransferase, YaeB family
HFP99_RS02275	ENOG4108JJ8	(ABC) transporter
HFP99_RS02280	ENOG4108JJ9	ABC, transporter
HFP99_RS02295	ENOG41065U4	response regulator
HFP99_RS02305	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HFP99_RS02320	ENOG4105VS7	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity)
HFP99_RS02325	ENOG4106FVC	RNA methyltransferase
HFP99_RS02335	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HFP99_RS02340	ENOG4105D98	threonine synthase
HFP99_RS02345	ENOG4108VSZ	Inherit from COG: ketosteroid isomerase-like protein
HFP99_RS02385	ENOG4107SDU	Methyl-accepting chemotaxis
HFP99_RS02395	ENOG4108ESY	Metal dependent phosphohydrolase
HFP99_RS02400	ENOG4105DR8	Membrane
HFP99_RS02405	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
HFP99_RS02410	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HFP99_RS02425	ENOG4105C2W	permease
HFP99_RS02440	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
HFP99_RS02450	ENOG4105EGS	Mechanosensitive ion channel
HFP99_RS02455	ENOG4105CA9	Pyruvate kinase
HFP99_RS02460	ENOG4105EZE	Cupin 4 family protein
HFP99_RS02465	ENOG4107QTF	adenylosuccinate lyase
HFP99_RS02470	ENOG41075W9	High frequency lysogenization protein HflD homolog
HFP99_RS02475	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HFP99_RS02495	ENOG4108YRF	PTS System
HFP99_RS02500	ENOG4105CXY	transporter
HFP99_RS02505	ENOG4105DM4	PTS System
HFP99_RS02520	ENOG4107NQ8	LysR family Transcriptional regulator
HFP99_RS02530	ENOG4108NZE	NAGC-like transcriptional regulator
HFP99_RS02540	ENOG4107QNK	)-transporter
HFP99_RS02550	ENOG4107VGF	ig domain protein group 2 domain protein
HFP99_RS02555	ENOG4105DM4	PTS System
HFP99_RS02570	ENOG4105EIP	mannose-6-phosphate isomerase
HFP99_RS02575	ENOG4106R3P	AraC family transcriptional regulator
HFP99_RS02580	ENOG4108HMX	isocitrate dehydrogenase (NADP)
HFP99_RS02590	ENOG4105BZC	d-serine deaminase
HFP99_RS02595	ENOG4105C6Z	Gluconate
HFP99_RS02600	ENOG4105W8I	Transcriptional regulator
HFP99_RS02615	ENOG4105Q26	Siderophore-interacting protein
HFP99_RS02620	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HFP99_RS02625	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HFP99_RS02630	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
HFP99_RS02640	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
HFP99_RS02650	ENOG4105BZU	Histidine kinase
HFP99_RS02655	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HFP99_RS02660	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HFP99_RS02665	ENOG4105CFG	Acts as a chaperone (By similarity)
HFP99_RS02670	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HFP99_RS02680	ENOG4105D7K	pfkb domain protein
HFP99_RS02695	ENOG4105WBN	Transcriptional regulator (LacI family
HFP99_RS02715	ENOG41080HT	Transcriptional regulator, arsr family
HFP99_RS02740	ENOG4105EFX	secretion protein, HlyD family
HFP99_RS02745	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HFP99_RS02750	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HFP99_RS02755	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HFP99_RS02760	ENOG4107RMF	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity)
HFP99_RS02775	ENOG4108IJF	Heavy metal efflux pump, CzcA
HFP99_RS02780	ENOG4105EP1	Efflux transporter rnd family, mfp subunit
HFP99_RS02790	ENOG4105CGK	Exodeoxyribonuclease III
HFP99_RS02805	ENOG4105VN1	Heat shock protein
HFP99_RS02815	ENOG41090JD	Blue (Type 1) copper domain protein
HFP99_RS02835	ENOG4105CC0	LysR family Transcriptional regulator
HFP99_RS02840	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
HFP99_RS02845	ENOG4105E2S	oxidase) subunit II
HFP99_RS02850	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HFP99_RS02855	ENOG4105CCU	oxidase (Subunit III)
HFP99_RS02860	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
HFP99_RS02865	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HFP99_RS02875	ENOG4107RDB	Major Facilitator
HFP99_RS02880	ENOG4105KCV	RNA signal recognition particle 4.5S RNA
HFP99_RS02890	ENOG4105CC0	LysR family Transcriptional regulator
HFP99_RS02910	ENOG4105CAF	HipA N-terminal domain protein
HFP99_RS02930	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HFP99_RS02935	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HFP99_RS02940	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HFP99_RS02945	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HFP99_RS02950	ENOG4108EFP	Anthranilate synthase component II
HFP99_RS02955	ENOG4105CRQ	synthase (Component I)
HFP99_RS02960	ENOG4105DB7	PHP domain protein
HFP99_RS02965	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HFP99_RS02975	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HFP99_RS02980	ENOG4105FE9	pseudouridine synthase
HFP99_RS02985	ENOG4105C29	acyl-CoA thioesterase
HFP99_RS03000	ENOG4107XI7	Tetr family transcriptional regulator
HFP99_RS03005	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HFP99_RS03010	ENOG4105BZS	acriflavin resistance protein
HFP99_RS03015	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HFP99_RS03020	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
HFP99_RS03030	ENOG4107SSZ	Phosphatase
HFP99_RS03040	ENOG4107QPN	acyl-Coa dehydrogenase
HFP99_RS03045	ENOG4105BZS	acriflavin resistance protein
HFP99_RS03055	ENOG4105CA9	Pyruvate kinase
HFP99_RS03060	ENOG4106KNT	transcriptional regulator
HFP99_RS03065	ENOG4105CHC	glucokinase (EC 2.7.1.2)
HFP99_RS03070	ENOG4105IFJ	Histidine kinase
HFP99_RS03080	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HFP99_RS03085	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
HFP99_RS03095	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
HFP99_RS03150	ENOG4108RT7	Glycosyl transferase, family 2
HFP99_RS03160	ENOG4105D3Q	Sugar transferase
HFP99_RS03170	ENOG4108KPN	Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12)
HFP99_RS03185	ENOG4108YXG	UPF0502 protein
HFP99_RS03195	ENOG4105KR1	Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity)
HFP99_RS03210	ENOG4107RUY	(E1 component), alpha subunit
HFP99_RS03215	ENOG4105CPP	Dehydrogenase, E1 component
HFP99_RS03220	ENOG4107QSN	dihydrolipoamide acetyltransferase
HFP99_RS03225	ENOG4105VEQ	Cold shock protein
HFP99_RS03255	ENOG4108594	Permease of the drug metabolite transporter
HFP99_RS03265	ENOG4105CPI	Metal Dependent Phosphohydrolase
HFP99_RS03270	ENOG4105I08	Pseudouridine synthase
HFP99_RS03280	ENOG4107QSI	ABC, transporter
HFP99_RS03285	ENOG4108RE9	Phosphodiesterase
HFP99_RS03300	ENOG4107ESN	Flagella basal body P-ring formation protein flgA
HFP99_RS03310	ENOG4105BZU	Histidine kinase
HFP99_RS03315	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
HFP99_RS03320	ENOG4108ZC9	flagellar basal-body rod protein flgc
HFP99_RS03330	ENOG4105BZE	flagellar hook protein, FlgE
HFP99_RS03335	ENOG4108KPB	Flagellar basal-body rod protein FlgF
HFP99_RS03340	ENOG4105CGA	flagellar basal-body rod protein FlgG
HFP99_RS03345	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HFP99_RS03350	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HFP99_RS03355	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
HFP99_RS03370	ENOG4105CJW	magnesium transporter
HFP99_RS03375	ENOG4105C9X	ppx gppa phosphatase
HFP99_RS03380	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HFP99_RS03385	ENOG4105RH4	Glycine cleavage system transcriptional repressor
HFP99_RS03400	ENOG4105BZU	Histidine kinase
HFP99_RS03410	ENOG4107QNR	UPF0135 protein
HFP99_RS03430	ENOG4105J12	Multidrug resistance protein mdtN
HFP99_RS03445	ENOG4105DN3	alpha-2-macroglobulin domain protein
HFP99_RS03450	ENOG4108JQB	penicillin-binding protein 1C
HFP99_RS03460	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
HFP99_RS03470	ENOG4105EN6	Membrane
HFP99_RS03475	ENOG4105I03	Flagellin
HFP99_RS03480	ENOG4105I03	Flagellin
HFP99_RS03495	ENOG4105MQ3	flagellar protein FliS
HFP99_RS03530	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HFP99_RS03535	ENOG4107TY6	Acylneuraminate cytidylyltransferase
HFP99_RS03545	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HFP99_RS03550	ENOG4105C5E	polysaccharide biosynthesis protein
HFP99_RS03555	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
HFP99_RS03565	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HFP99_RS03585	ENOG4108UYE	Lactoylglutathione lyase
HFP99_RS03590	ENOG4105CSM	endonuclease III
HFP99_RS03600	ENOG4108UQQ	Electron transport complex
HFP99_RS03605	ENOG4105D6A	Electron transport complex
HFP99_RS03615	ENOG4108R3D	Electron transport complex
HFP99_RS03620	ENOG4105DGN	Electron transport complex
HFP99_RS03635	ENOG4107SDU	Methyl-accepting chemotaxis
HFP99_RS03645	ENOG4105M7P	phage repressor
HFP99_RS03760	ENOG4108Z6H	mu-like prophage Flumu protein gp27
HFP99_RS03765	ENOG4105CF2	Mu-like prophage FluMu protein GP28
HFP99_RS03770	ENOG4105QIB	mu-like prophage Flumu protein gp29
HFP99_RS03790	ENOG4108TVE	i protein
HFP99_RS03795	ENOG4105EFV	Major head subunit
HFP99_RS03870	ENOG4105RKW	reductase (By
HFP99_RS03875	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
HFP99_RS03880	ENOG4105CHM	Aminotransferase
HFP99_RS03890	ENOG41090BQ	Glutaredoxin
HFP99_RS03895	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
HFP99_RS03900	ENOG4105CFI	type iii restriction protein res subunit
HFP99_RS03905	ENOG4105EFX	secretion protein, HlyD family
HFP99_RS03910	ENOG4105KK7	inner membrane protein YiaW
HFP99_RS03915	ENOG4105EGS	Mechanosensitive ion channel
HFP99_RS03925	ENOG4108NEV	two component transcriptional regulator, LytTR family
HFP99_RS03935	ENOG4105CPI	Metal Dependent Phosphohydrolase
HFP99_RS03940	ENOG4105C0A	alcohol dehydrogenase
HFP99_RS03945	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
HFP99_RS03950	ENOG4107QSI	ABC, transporter
HFP99_RS03955	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HFP99_RS03960	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HFP99_RS03965	ENOG4105C3U	ABC transporter
HFP99_RS03975	ENOG4108JQ7	(ABC) transporter
HFP99_RS03980	ENOG4105DU1	integral membrane protein, terc
HFP99_RS03985	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HFP99_RS03995	ENOG4105CK2	sodium dicarboxylate symporter
HFP99_RS04010	ENOG4105CD3	dihydroorotase
HFP99_RS04020	ENOG4108NVR	Methyl-accepting chemotaxis
HFP99_RS04025	ENOG4105K59	histidine triad (HIT) protein
HFP99_RS04060	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HFP99_RS04065	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HFP99_RS04080	ENOG4105CKW	Inner membrane protein yedI
HFP99_RS04085	ENOG4105DPN	Oligoendopeptidase f
HFP99_RS04090	ENOG4105DPN	Oligoendopeptidase f
HFP99_RS04095	ENOG4105D0Y	UPF0227 protein
HFP99_RS04100	ENOG4105CEP	NADH dehydrogenase
HFP99_RS04105	ENOG4105K8R	UPF0145 protein
HFP99_RS04110	ENOG4107T7U	Sulfatase
HFP99_RS04120	ENOG4105CFH	Aspartokinase
HFP99_RS04125	ENOG4107QZM	n-acetylglutamate synthase
HFP99_RS04130	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HFP99_RS04170	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HFP99_RS04190	ENOG4105C2C	drug resistance transporter, Bcr CflA
HFP99_RS04210	ENOG4105CVN	desaturase
HFP99_RS04215	ENOG4107SJW	iron permease, FTR1
HFP99_RS04265	ENOG4105CHH	sulfate transporter
HFP99_RS04300	ENOG4108WC9	type VI secretion system effector, hcp1 family
HFP99_RS04310	ENOG4105CS6	Rhs element vgr protein
HFP99_RS04320	ENOG4105CNA	YD repeat protein
HFP99_RS04385	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HFP99_RS04420	ENOG4105CS6	Rhs element vgr protein
HFP99_RS04445	ENOG4105E3S	small subunit
HFP99_RS04450	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
HFP99_RS04455	ENOG4105CJ5	hydrogenase 2 b cytochrome subunit
HFP99_RS04460	ENOG4105DPX	Hydrogenase, large subunit
HFP99_RS04465	ENOG4108USZ	hydrogenase
HFP99_RS04470	ENOG4108WGS	hydrogenase 2-specific chaperone
HFP99_RS04480	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HFP99_RS04485	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HFP99_RS04495	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HFP99_RS04500	ENOG4107RSS	Hydrogenase accessory protein HypB
HFP99_RS04505	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
HFP99_RS04510	ENOG4105C45	hydrogenase expression formation protein (HypE)
HFP99_RS04515	ENOG4105CQS	hydrogenase expression formation protein HypD
HFP99_RS04520	ENOG4105WRB	Hydrogenase assembly chaperone hypC hupF
HFP99_RS04530	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HFP99_RS04535	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HFP99_RS04540	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HFP99_RS04545	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HFP99_RS04555	ENOG4107RE1	Inosine-guanosine kinase
HFP99_RS04560	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_RS04575	ENOG4105BZU	Histidine kinase
HFP99_RS04580	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HFP99_RS04590	ENOG4105F3T	(LipO)protein
HFP99_RS04605	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
HFP99_RS04610	ENOG4105WQI	isochorismatase
HFP99_RS04615	ENOG4105CEY	Amp-dependent synthetase and ligase
HFP99_RS04620	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
HFP99_RS04630	ENOG4105C0W	non-ribosomal peptide synthetase
HFP99_RS04640	ENOG4108TSE	Transferase
HFP99_RS04645	ENOG4105E0A	ABC, transporter
HFP99_RS04650	ENOG4105TVJ	transport system, permease
HFP99_RS04655	ENOG4105DQ5	transport system permease protein
HFP99_RS04660	ENOG4105D05	Receptor
HFP99_RS04675	ENOG4105QZU	Inner membrane protein YfeZ
HFP99_RS04685	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HFP99_RS04690	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HFP99_RS04695	ENOG4105BZJ	Electron transfer flavoprotein
HFP99_RS04700	ENOG4105C10	Electron transfer flavoprotein
HFP99_RS04705	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HFP99_RS04710	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HFP99_RS04715	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HFP99_RS04720	ENOG4105EE5	Membrane protein terC
HFP99_RS04730	ENOG4105MH2	YfcL protein
HFP99_RS04735	ENOG4108IQE	Amp-dependent synthetase and ligase
HFP99_RS04740	ENOG4107T42	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity)
HFP99_RS04745	ENOG41067MG	lrgb family
HFP99_RS04755	ENOG4107R49	K07407 alpha-galactosidase EC 3.2.1.22
HFP99_RS04765	ENOG4105CJB	Exodeoxyribonuclease I
HFP99_RS04785	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HFP99_RS04825	ENOG4105DZR	Type I site-specific deoxyribonuclease
HFP99_RS04855	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HFP99_RS04895	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HFP99_RS04910	ENOG4105CHM	Aminotransferase
HFP99_RS04915	ENOG4105ETT	transcriptional Regulator, LysR family
HFP99_RS04920	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
HFP99_RS04930	ENOG4105EF1	ribulokinase
HFP99_RS04935	ENOG4105DMK	Periplasmic binding protein LacI transcriptional regulator
HFP99_RS04945	ENOG4105CNN	ABC, transporter
HFP99_RS04955	ENOG4105YK5	50S ribosomal protein L36
HFP99_RS04960	ENOG4105NRA	50s ribosomal protein l31 type b
HFP99_RS04965	ENOG4105CAX	The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity)
HFP99_RS04970	ENOG4105XEP	YhcH YjgK YiaL family protein
HFP99_RS04975	ENOG4108UHU	Aldolase
HFP99_RS04980	ENOG4107SS6	2-dehydro-3-deoxygluconokinase
HFP99_RS04985	ENOG4105J4Q	Transcriptional regulator
HFP99_RS04990	ENOG4105P66	Membrane
HFP99_RS04995	ENOG4105CHR	reductase
HFP99_RS05015	ENOG4108VKG	metal-dependent hydrolase
HFP99_RS05030	ENOG4105CEE	C4-dicarboxylate transporter
HFP99_RS05040	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
HFP99_RS05045	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HFP99_RS05060	ENOG4105BZN	citrate synthase
HFP99_RS05065	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
HFP99_RS05070	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
HFP99_RS05075	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
HFP99_RS05080	ENOG4105E33	succinate dehydrogenase
HFP99_RS05085	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HFP99_RS05090	ENOG4105C7S	Dehydrogenase
HFP99_RS05095	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HFP99_RS05100	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HFP99_RS05115	ENOG4105CJP	fad dependent oxidoreductase
HFP99_RS05120	ENOG4107RCV	ABC transporter, permease
HFP99_RS05130	ENOG4105C4Y	ABC transporter
HFP99_RS05140	ENOG4107STF	Involved in phosphonate degradation (By similarity)
HFP99_RS05145	ENOG4108JPW	Aminotransferase
HFP99_RS05150	ENOG4108KAZ	Involved in phosphonate degradation (By similarity)
HFP99_RS05155	ENOG4105C6N	Formate acetyltransferase
HFP99_RS05160	ENOG4105TMB	Formate nitrite transporter
HFP99_RS05165	ENOG4105DDY	UPF0142 protein ycaO
HFP99_RS05180	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HFP99_RS05185	ENOG4105VEQ	Cold shock protein
HFP99_RS05190	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
HFP99_RS05195	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HFP99_RS05200	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HFP99_RS05205	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
HFP99_RS05210	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HFP99_RS05215	ENOG4107MBR	17 kDa surface antigen
HFP99_RS05220	ENOG4105BZU	Histidine kinase
HFP99_RS05225	ENOG4105C3M	thioredoxin reductase
HFP99_RS05230	ENOG4105DCF	alanine dehydrogenase
HFP99_RS05235	ENOG4105EW9	transcriptional regulator AsnC family
HFP99_RS05240	ENOG4105CNU	cell division protein FtsK
HFP99_RS05245	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
HFP99_RS05250	ENOG4105D1H	recombination factor protein RarA
HFP99_RS05255	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HFP99_RS05260	ENOG4105E96	Colicin v production protein
HFP99_RS05265	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HFP99_RS05270	ENOG4105CS2	ec 3.2.1.21
HFP99_RS05275	ENOG4105C5Y	PTS System
HFP99_RS05280	ENOG4105DDV	Transcriptional regulator (LacI family
HFP99_RS05285	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
HFP99_RS05290	ENOG4108JQ2	peptide transport system atp-binding protein
HFP99_RS05300	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
HFP99_RS05310	ENOG4108I5W	peptide transport system, permease protein
HFP99_RS05315	ENOG4108J59	Extracellular solute-binding protein, family 5
HFP99_RS05320	ENOG4105E51	psp operon transcriptional activator
HFP99_RS05325	ENOG41087YS	Phage shock protein A
HFP99_RS05330	ENOG4105YYT	phage shock protein B
HFP99_RS05340	ENOG4105CM6	amino acid regulated cytosolic protein
HFP99_RS05345	ENOG4106K28	UPF0283 membrane protein
HFP99_RS05350	ENOG4105MIR	Phenylalanine 4-monooxygenase
HFP99_RS05355	ENOG41090A4	Pterin carbinolamine dehydratase
HFP99_RS05365	ENOG4108WS1	
HFP99_RS05370	ENOG4108KHX	Diguanylate cyclase
HFP99_RS05375	ENOG41090EK	ompa motb domain protein
HFP99_RS05380	ENOG4105D4P	Coproporphyrinogen iii oxidase
HFP99_RS05385	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HFP99_RS05400	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HFP99_RS05405	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HFP99_RS05430	ENOG4105FQ6	thiopurine methyltransferase
HFP99_RS05435	ENOG4107QXK	peptidase
HFP99_RS05440	ENOG4108BY2	phosphohistidine phosphatase
HFP99_RS05450	ENOG4108IPJ	Membrane
HFP99_RS05455	ENOG4108J59	Extracellular solute-binding protein, family 5
HFP99_RS05460	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HFP99_RS05475	ENOG4105D60	lipoprotein releasing system transmembrane protein
HFP99_RS05480	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HFP99_RS05485	ENOG4105D60	lipoprotein releasing system transmembrane protein
HFP99_RS05490	ENOG4105DK2	UPF0207 protein
HFP99_RS05500	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HFP99_RS05505	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HFP99_RS05510	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HFP99_RS05515	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HFP99_RS05520	ENOG4105K70	DNA-binding protein
HFP99_RS05525	ENOG4105EIN	peptidylprolyl cis-trans isomerase
HFP99_RS05530	ENOG4105C5H	ABC transporter
HFP99_RS05535	ENOG4107QN1	sodium solute
HFP99_RS05540	ENOG41062QD	Membrane
HFP99_RS05555	ENOG41060WC	Enoyl-CoA hydratase
HFP99_RS05560	ENOG4105BZG	amino acid carrier protein
HFP99_RS05575	ENOG4106HK8	GPR1 FUN34 yaaH family protein
HFP99_RS05590	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
HFP99_RS05605	ENOG4105E39	Enoyl-CoA hydratase
HFP99_RS05610	ENOG4107QX3	carboxylase
HFP99_RS05615	ENOG4105C1G	acyl-Coa dehydrogenase
HFP99_RS05620	ENOG4105C26	Dehydrogenase
HFP99_RS05625	ENOG4105C1G	acyl-Coa dehydrogenase
HFP99_RS05630	ENOG4105E39	Enoyl-CoA hydratase
HFP99_RS05635	ENOG4105E39	Enoyl-CoA hydratase
HFP99_RS05640	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HFP99_RS05645	ENOG4105CHR	reductase
HFP99_RS05650	ENOG4105D5Q	Arginine ornithine antiporter
HFP99_RS05655	ENOG4105HF0	Membrane
HFP99_RS05665	ENOG4105HEI	LysR family (Transcriptional regulator
HFP99_RS05675	ENOG41079Y2	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone
HFP99_RS05680	ENOG410642W	LysR family Transcriptional regulator
HFP99_RS05690	ENOG4105HEI	LysR family (Transcriptional regulator
HFP99_RS05695	ENOG4107QW4	alcohol dehydrogenase
HFP99_RS05700	ENOG4107SET	aldo keto reductase
HFP99_RS05715	ENOG4105C2C	drug resistance transporter, Bcr CflA
HFP99_RS05720	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
HFP99_RS05730	ENOG4105D01	(LipO)protein
HFP99_RS05745	ENOG4107R9N	ABC transporter
HFP99_RS05750	ENOG4105C2J	ABC transporter
HFP99_RS05755	ENOG4107R5U	Periplasmic binding protein LacI transcriptional regulator
HFP99_RS05775	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
HFP99_RS05780	ENOG4107QKC	Oxidoreductase alpha (molybdopterin) subunit
HFP99_RS05795	ENOG4105BZU	Histidine kinase
HFP99_RS05800	ENOG4105DND	Transcriptional regulator
HFP99_RS05805	ENOG4105CS2	ec 3.2.1.21
HFP99_RS05810	ENOG4105CHR	reductase
HFP99_RS05815	ENOG4105CBN	LysR family transcriptional regulator
HFP99_RS05830	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
HFP99_RS05850	ENOG4105D1S	lipid A biosynthesis
HFP99_RS05855	ENOG4105D1S	lipid A biosynthesis
HFP99_RS05865	ENOG4105EUB	pirin domain protein
HFP99_RS05880	ENOG4105CQ2	DNA polymerase
HFP99_RS05910	ENOG4107QI1	Mate efflux family protein
HFP99_RS05915	ENOG4105W1I	UPF0253 protein
HFP99_RS05920	ENOG4108R6K	riboflavin synthase, subunit alpha
HFP99_RS05930	ENOG4107UW8	HAD-superfamily hydrolase subfamily IA variant 3
HFP99_RS05935	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
HFP99_RS05940	ENOG4108SXK	Transporter Drug Metabolite Exporter family
HFP99_RS05945	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
HFP99_RS05980	ENOG4105XW2	UPF0263 protein
HFP99_RS05985	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
HFP99_RS05990	ENOG4108W5H	UPF0263 protein
HFP99_RS05995	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
HFP99_RS06000	ENOG4107QMS	site-determining protein
HFP99_RS06005	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
HFP99_RS06010	ENOG4105VNG	YcgL domain-containing protein
HFP99_RS06015	ENOG4105CVE	Lytic murein transglycosylase
HFP99_RS06020	ENOG4105EJQ	L-serine dehydratase
HFP99_RS06025	ENOG4105EJQ	L-serine dehydratase
HFP99_RS06030	ENOG4105NBK	UPF0345 protein
HFP99_RS06045	ENOG4105CHU	acetyl-coa acetyltransferase
HFP99_RS06050	ENOG4105D58	Diguanylate phosphodiesterase
HFP99_RS06055	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HFP99_RS06060	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HFP99_RS06110	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HFP99_RS06115	ENOG4105CHU	acetyl-coa acetyltransferase
HFP99_RS06120	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HFP99_RS06130	ENOG4108VWS	Yaeq family
HFP99_RS06160	ENOG4105EHG	Permease protein
HFP99_RS06175	ENOG4107MBR	17 kDa surface antigen
HFP99_RS06180	ENOG4105CEY	Amp-dependent synthetase and ligase
HFP99_RS06210	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HFP99_RS06215	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HFP99_RS06220	ENOG4105BZU	Histidine kinase
HFP99_RS06230	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HFP99_RS06235	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HFP99_RS06240	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HFP99_RS06250	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HFP99_RS06260	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HFP99_RS06270	ENOG4105DVT	helicase
HFP99_RS06275	ENOG41072GX	Peptidase M22 Glycoprotease
HFP99_RS06285	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
HFP99_RS06290	ENOG4105CEY	Amp-dependent synthetase and ligase
HFP99_RS06305	ENOG4105DXC	membrane
HFP99_RS06315	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
HFP99_RS06320	ENOG4105WD1	Membrane
HFP99_RS06325	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HFP99_RS06330	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HFP99_RS06335	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HFP99_RS06340	ENOG4105CHJ	isochorismatase hydrolase
HFP99_RS06345	ENOG4105CHJ	isochorismatase hydrolase
HFP99_RS06355	ENOG4105HEI	LysR family (Transcriptional regulator
HFP99_RS06360	ENOG4105DWD	nucleoside recognition domain protein
HFP99_RS06365	ENOG4105WH1	Two component transcriptional regulator luxr family
HFP99_RS06375	ENOG4105CQ7	ATP-dependent helicase
HFP99_RS06385	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HFP99_RS06390	ENOG4105C5X	domain protein
HFP99_RS06400	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
HFP99_RS06405	ENOG4105FAT	Acyl-transferase
HFP99_RS06415	ENOG4105DR4	Methyltransferase
HFP99_RS06420	ENOG4108N3W	hemolysin secretion protein
HFP99_RS06425	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
HFP99_RS06435	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HFP99_RS06440	ENOG4105D1F	ATP-binding protein
HFP99_RS06445	ENOG4105DBI	uridine monophosphokinase
HFP99_RS06450	ENOG4105DHP	deoxycytidine triphosphate deaminase
HFP99_RS06455	ENOG4105CJ3	phosphate transporter
HFP99_RS06465	ENOG41086KC	Transcriptional regulator
HFP99_RS06485	ENOG4108JJ6	Type I secretion system ATPase
HFP99_RS06510	ENOG4105C03	ribonuclease
HFP99_RS06515	ENOG4105EI2	Pseudouridine synthase
HFP99_RS06525	ENOG4108UHJ	MAF-like protein
HFP99_RS06535	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
HFP99_RS06540	ENOG4105VGS	50s ribosomal protein l32
HFP99_RS06545	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HFP99_RS06550	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HFP99_RS06555	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HFP99_RS06560	ENOG4105CHR	reductase
HFP99_RS06565	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HFP99_RS06570	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HFP99_RS06575	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
HFP99_RS06580	ENOG4105HHA	aminodeoxychorismate lyase
HFP99_RS06585	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HFP99_RS06590	ENOG4107QRG	dna polymerase iii
HFP99_RS06595	ENOG4105F8V	Hydrolase, tatD family
HFP99_RS06610	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HFP99_RS06615	ENOG4105DY2	Paraquat-inducible protein b
HFP99_RS06620	ENOG4105H2K	paraquat-inducible protein a
HFP99_RS06630	ENOG4105X2V	dna damage-inducible protein
HFP99_RS06640	ENOG4105DAN	ATP-dependent protease
HFP99_RS06645	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
HFP99_RS06650	ENOG4105WFT	During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity)
HFP99_RS06660	ENOG4105C5H	ABC transporter
HFP99_RS06670	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HFP99_RS06675	ENOG4108T7E	Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity)
HFP99_RS06680	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HFP99_RS06685	ENOG4105C7I	Dehydrogenase
HFP99_RS06695	ENOG4105CD8	aminopeptidase N
HFP99_RS06700	ENOG4105CN1	protease
HFP99_RS06710	ENOG4108ZGC	gaf domain protein
HFP99_RS06720	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
HFP99_RS06735	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
HFP99_RS06760	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HFP99_RS06765	ENOG4105Q9Y	Universal stress protein
HFP99_RS06770	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
HFP99_RS06785	ENOG4108RXX	maleylacetoacetate isomerase
HFP99_RS06790	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
HFP99_RS06795	ENOG4105C2J	ABC transporter
HFP99_RS06800	ENOG4105CNN	ABC, transporter
HFP99_RS06805	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HFP99_RS06810	ENOG4108RVA	ribokinase
HFP99_RS06815	ENOG4105ETE	Transcriptional regulator (LacI family
HFP99_RS06820	ENOG4105BZU	Histidine kinase
HFP99_RS06830	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HFP99_RS06845	ENOG4105BZU	Histidine kinase
HFP99_RS06850	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HFP99_RS06855	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HFP99_RS06860	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HFP99_RS06865	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HFP99_RS06875	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HFP99_RS06880	ENOG4105C22	threonyL-tRNA synthetase
HFP99_RS06910	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HFP99_RS06915	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HFP99_RS06920	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HFP99_RS06925	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HFP99_RS06930	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HFP99_RS06935	ENOG4105XPH	Ferredoxin
HFP99_RS06940	ENOG4105CA3	membrane-bound lytic murein transglycosylase
HFP99_RS06945	ENOG4105XZD	Fe-S protein
HFP99_RS06950	ENOG4105DM4	PTS System
HFP99_RS06955	ENOG4105DE4	1-phosphofructokinase
HFP99_RS06960	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
HFP99_RS06965	ENOG4107B7Y	DNA-binding transcriptional regulator FruR
HFP99_RS06970	ENOG4105E0U	tyrosine-specific transport protein
HFP99_RS06985	ENOG4105WJG	Glutathione
HFP99_RS06990	ENOG4105C1J	atp-dependent rna helicase
HFP99_RS07000	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HFP99_RS07005	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
HFP99_RS07010	ENOG4108DG9	Smr protein MutS2
HFP99_RS07045	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HFP99_RS07055	ENOG4105JAB	phenazine biosynthesis protein, phzf family
HFP99_RS07070	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HFP99_RS07085	ENOG4105D9N	nucleoside
HFP99_RS07090	ENOG4107U5R	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
HFP99_RS07150	ENOG4105DUC	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity)
HFP99_RS07155	ENOG4105DAH	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity)
HFP99_RS07160	ENOG4105GHU	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity)
HFP99_RS07165	ENOG4106371	Methyltransferase
HFP99_RS07170	ENOG4107S90	membrAne
HFP99_RS07180	ENOG4105CTQ	phosphohexokinase
HFP99_RS07190	ENOG4105CH2	amidohydrolase
HFP99_RS07195	ENOG4105PAD	Hydrolase
HFP99_RS07200	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HFP99_RS07265	ENOG4105VP0	transcriptional regulator, lysR family
HFP99_RS07270	ENOG4105EJ9	Membrane
HFP99_RS07275	ENOG4106IUH	DTW domain containing protein
HFP99_RS07285	ENOG4105CPF	Cell wall formation (By similarity)
HFP99_RS07300	ENOG4105C1J	atp-dependent rna helicase
HFP99_RS07305	ENOG4105K5X	acetyltransferase
HFP99_RS07315	ENOG4105KK4	UPF0060 membrane protein
HFP99_RS07340	ENOG41061CK	Antibiotic biosynthesis monooxygenase
HFP99_RS07345	ENOG4107XGF	functions in a salvage pathway. Uses pyridoxamine (By similarity)
HFP99_RS07365	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
HFP99_RS07375	ENOG4105WQ3	Rna-binding protein
HFP99_RS07390	ENOG4105BZ1	(ABC) transporter
HFP99_RS07395	ENOG4105BZ1	(ABC) transporter
HFP99_RS07400	ENOG4105BZU	Histidine kinase
HFP99_RS07405	ENOG4105K63	Thioredoxin
HFP99_RS07410	ENOG4105C8P	)-transporter
HFP99_RS07420	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
HFP99_RS07440	ENOG4105CRQ	synthase (Component I)
HFP99_RS07445	ENOG4105P8F	nudix hydrolase
HFP99_RS07450	ENOG4105C44	Serine transporter
HFP99_RS07455	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
HFP99_RS07460	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HFP99_RS07465	ENOG4105CYN	Serine protein kinase
HFP99_RS07470	ENOG4106AKX	UPF0229 protein
HFP99_RS07475	ENOG4105ED1	spovr family
HFP99_RS07480	ENOG4105C05	Multifunctional regulator of fatty acid metabolism (By similarity)
HFP99_RS07485	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HFP99_RS07490	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
HFP99_RS07495	ENOG4105DQR	SNARE associated Golgi
HFP99_RS07505	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HFP99_RS07515	ENOG4105D0C	transport protein
HFP99_RS07520	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
HFP99_RS07540	ENOG4108MRH	transcriptional regulatory protein
HFP99_RS07545	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
HFP99_RS07550	ENOG4105E2R	ROK family
HFP99_RS07555	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_RS07560	ENOG4105K5B	UPF0225 protein
HFP99_RS07565	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
HFP99_RS07570	ENOG4108KJ0	anaerobic glycerol-3-phosphate dehydrogenase, subunit B
HFP99_RS07575	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HFP99_RS07590	ENOG4105JJ8	Cytochrome c nitrite reductase, pentaheme subunit
HFP99_RS07595	ENOG4105D3S	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
HFP99_RS07600	ENOG4105DVI	reductase, NrfD
HFP99_RS07605	ENOG4105DA4	cytochrome c-type biogenesis protein
HFP99_RS07610	ENOG4107QX9	Thiol disulfide interChange protein
HFP99_RS07615	ENOG4108DMF	Cytochrome C biogenesis protein
HFP99_RS07625	ENOG41061WM	D-Alanyl-D-Alanine
HFP99_RS07635	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
HFP99_RS07640	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
HFP99_RS07655	ENOG4105W87	Cbs domain
HFP99_RS07665	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
HFP99_RS07670	ENOG4105DZ2	Transcriptional regulator
HFP99_RS07680	ENOG4105E0K	tonB-dependent siderophore receptor
HFP99_RS07685	ENOG4106TD9	Diguanylate cyclase
HFP99_RS07690	ENOG4105UEI	Transcriptional Regulator AraC Family
HFP99_RS07700	ENOG4105CR8	Transcriptional regulator
HFP99_RS07705	ENOG4108RYK	Nad-dependent epimerase dehydratase
HFP99_RS07715	ENOG4105C28	cystathionine
HFP99_RS07720	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HFP99_RS07740	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
HFP99_RS07750	ENOG4105ETE	Transcriptional regulator (LacI family
HFP99_RS07755	ENOG4105CNT	hydrolase family 2
HFP99_RS07760	ENOG4105U0F	oligosaccharide H symporter, major facilitator superfamily (MFS)
HFP99_RS07770	ENOG4108RMJ	sensory transduction regulator
HFP99_RS07780	ENOG4107104	thymidine kinase
HFP99_RS07785	ENOG4107S6Z	Na H antiporter
HFP99_RS07795	ENOG4108WBT	adenosyltransferase
HFP99_RS07800	ENOG4105VRT	cytoplasmic protein
HFP99_RS07805	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HFP99_RS07810	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
HFP99_RS07825	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
HFP99_RS07830	ENOG4105CFV	Tetratricopeptide repeat protein
HFP99_RS07840	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HFP99_RS07845	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HFP99_RS07850	ENOG4105CAT	Cytidine monophosphate kinase
HFP99_RS07855	ENOG4108JEN	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
HFP99_RS07860	ENOG4105DUM	transcriptional regulator, lysR family
HFP99_RS07865	ENOG4105D2S	major facilitator superfamily
HFP99_RS07880	ENOG4108DBC	nitroreductase
HFP99_RS07885	ENOG4105CFC	Transporter
HFP99_RS07890	ENOG4105BZU	Histidine kinase
HFP99_RS07900	ENOG4105CBN	LysR family transcriptional regulator
HFP99_RS07905	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HFP99_RS07930	ENOG4107RGM	aldo keto reductase
HFP99_RS07935	ENOG4105VFU	Rna-binding protein
HFP99_RS07945	ENOG4105HPZ	Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity)
HFP99_RS07955	ENOG4105HA9	of methanol dehydrogenase type
HFP99_RS07980	ENOG4105ER2	Ompa motb domain protein
HFP99_RS07985	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HFP99_RS07990	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HFP99_RS07995	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HFP99_RS08000	ENOG4105GKE	subunit e
HFP99_RS08005	ENOG4107QIZ	NADH dehydrogenase
HFP99_RS08010	ENOG4108IEH	NADH dehydrogenase subunit g
HFP99_RS08015	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HFP99_RS08020	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HFP99_RS08025	ENOG4107UFS	subunit j
HFP99_RS08030	ENOG41080EA	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HFP99_RS08035	ENOG4105D65	subunit l
HFP99_RS08040	ENOG4105C8S	subunit m
HFP99_RS08045	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HFP99_RS08050	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HFP99_RS08055	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
HFP99_RS08060	ENOG4105VPD	cellular component movement
HFP99_RS08065	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HFP99_RS08070	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HFP99_RS08075	ENOG4105N21	Membrane
HFP99_RS08080	ENOG4105CUT	histidyl-tRNA synthetase
HFP99_RS08085	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HFP99_RS08090	ENOG4105HSZ	Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity)
HFP99_RS08100	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HFP99_RS08105	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HFP99_RS08120	ENOG4108ZIT	Ferredoxin, 2FE-2S
HFP99_RS08125	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
HFP99_RS08130	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
HFP99_RS08135	ENOG4108Z4V	iron-sulfur cluster assembly
HFP99_RS08140	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
HFP99_RS08145	ENOG4105C3J	Cysteine desulfurase
HFP99_RS08150	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
HFP99_RS08155	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
HFP99_RS08185	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
HFP99_RS08190	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HFP99_RS08195	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HFP99_RS08200	ENOG4105VIE	preprotein translocase, subunit YajC
HFP99_RS08205	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HFP99_RS08210	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HFP99_RS08215	ENOG4105W87	Cbs domain
HFP99_RS08220	ENOG4105D3R	alkyl hydroperoxide reductase
HFP99_RS08240	ENOG4105BZU	Histidine kinase
HFP99_RS08280	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HFP99_RS08285	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HFP99_RS08290	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HFP99_RS08295	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HFP99_RS08300	ENOG4105D0A	hydroxylase
HFP99_RS08320	ENOG4105ETE	Transcriptional regulator (LacI family
HFP99_RS08325	ENOG4105C2J	ABC transporter
HFP99_RS08330	ENOG4105CNN	ABC, transporter
HFP99_RS08335	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HFP99_RS08350	ENOG4105E5M	Multidrug resistance protein D
HFP99_RS08355	ENOG4105C3U	ABC transporter
HFP99_RS08360	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HFP99_RS08365	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HFP99_RS08375	ENOG4105CYM	Glutathione S-transferase
HFP99_RS08380	ENOG4108RXX	maleylacetoacetate isomerase
HFP99_RS08390	ENOG4105ECY	inositol monophosphatase
HFP99_RS08395	ENOG4105EIY	sodium-type flagellar protein motY
HFP99_RS08400	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
HFP99_RS08405	ENOG4105D3Y	Na H antiporter
HFP99_RS08415	ENOG4105EQ2	LysR family Transcriptional regulator
HFP99_RS08420	ENOG4105C1J	atp-dependent rna helicase
HFP99_RS08425	ENOG4105KA0	thioesterase Superfamily protein
HFP99_RS08435	ENOG4105CQB	FAD linked oxidase domain protein
HFP99_RS08455	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HFP99_RS08465	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
HFP99_RS08475	ENOG4105CAQ	asparagine synthetase
HFP99_RS08485	ENOG4108RXX	maleylacetoacetate isomerase
HFP99_RS08495	ENOG4105F1J	Homogentisate 1,2-dioxygenase
HFP99_RS08500	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
HFP99_RS08510	ENOG4108W1A	pseudouridine synthase
HFP99_RS08520	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
HFP99_RS08525	ENOG4105CEY	Amp-dependent synthetase and ligase
HFP99_RS08550	ENOG4105D25	secreted protein
HFP99_RS08580	ENOG4108J8C	transporter major facilitator family protein
HFP99_RS08590	ENOG4105E2B	Taurine dioxygenase
HFP99_RS08595	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
HFP99_RS08600	ENOG4105CR4	methylisocitrate lyase
HFP99_RS08605	ENOG4105BZN	citrate synthase
HFP99_RS08610	ENOG4108I0Z	Aconitate hydratase
HFP99_RS08615	ENOG4105C7F	AcnD-accessory protein PrpF
HFP99_RS08625	ENOG4108MN8	Membrane
HFP99_RS08630	ENOG4105EM2	membrane
HFP99_RS08635	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
HFP99_RS08640	ENOG4108S3P	Sporulation domain protein
HFP99_RS08645	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HFP99_RS08650	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HFP99_RS08655	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HFP99_RS08665	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HFP99_RS08670	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
HFP99_RS08675	ENOG4105YVM	Phosphoesterase, PA-phosphatase related
HFP99_RS08680	ENOG4105D01	(LipO)protein
HFP99_RS08695	ENOG4105DKW	ABC transporter
HFP99_RS08710	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HFP99_RS08715	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
HFP99_RS08725	ENOG4105C85	amino acid
HFP99_RS08760	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
HFP99_RS08770	ENOG4105N5T	Radical SAM Protein
HFP99_RS08775	ENOG4105CBC	glutamate synthase
HFP99_RS08780	ENOG4105BZ8	glutamate synthase
HFP99_RS08795	ENOG4105C1J	atp-dependent rna helicase
HFP99_RS08820	ENOG4107QS8	(LipO)protein
HFP99_RS08825	ENOG4105BZU	Histidine kinase
HFP99_RS08830	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HFP99_RS08840	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HFP99_RS08845	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HFP99_RS08850	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HFP99_RS08860	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HFP99_RS08865	ENOG4105E66	phosphoriboisomerase A
HFP99_RS08870	ENOG4108JQ1	Dehydrogenase
HFP99_RS08875	ENOG41080IJ	Diacylglycerol kinase
HFP99_RS08880	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HFP99_RS08885	ENOG41080WI	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity)
HFP99_RS08890	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
HFP99_RS08905	ENOG4105CZX	twitching motility protein
HFP99_RS08930	ENOG4108ZJT	translation initiation factor, Sui1
HFP99_RS08970	ENOG410620I	Diguanylate cyclase
HFP99_RS08975	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HFP99_RS08980	ENOG4107QKA	exodeoxyribonuclease V beta
HFP99_RS08990	ENOG4105C8N	cysteinyl-tRNA synthetase
HFP99_RS08995	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HFP99_RS09005	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
HFP99_RS09010	ENOG4105Y3U	Transglycosylase-associated protein
HFP99_RS09015	ENOG4108TGY	Glutathione S-transferase
HFP99_RS09055	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HFP99_RS09060	ENOG4105WH1	Two component transcriptional regulator luxr family
HFP99_RS09065	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HFP99_RS09070	ENOG4105W49	UPF0434 protein
HFP99_RS09075	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HFP99_RS09080	ENOG4105BZ1	(ABC) transporter
HFP99_RS09100	ENOG4105D7A	ATP-binding protein
HFP99_RS09105	ENOG4105CGF	Aromatic amino acid aminotransferase
HFP99_RS09120	ENOG4105DVT	helicase
HFP99_RS09130	ENOG4105DGU	Histone deacetylase
HFP99_RS09135	ENOG4108ISG	Major Facilitator
HFP99_RS09140	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
HFP99_RS09145	ENOG4105G6Z	alkaline phosphatase
HFP99_RS09165	ENOG4105NXH	GreA GreB family elongation factor
HFP99_RS09170	ENOG4108KX4	response regulator
HFP99_RS09175	ENOG4105BZU	Histidine kinase
HFP99_RS09180	ENOG4105CXY	transporter
HFP99_RS09190	ENOG4106TNF	Periplasmic binding protein
HFP99_RS09195	ENOG4105E5Q	amino acid AbC transporter
HFP99_RS09200	ENOG4105CDA	abc transporter atp-binding protein
HFP99_RS09215	ENOG4105D5Q	Arginine ornithine antiporter
HFP99_RS09230	ENOG4105C37	(CBS) domain
HFP99_RS09235	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
HFP99_RS09240	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HFP99_RS09245	ENOG4105E2Z	phosphate ABC transporter (Permease
HFP99_RS09250	ENOG4105C8U	phosphate abc transporter
HFP99_RS09255	ENOG4108Z6B	deaminase
HFP99_RS09280	ENOG4107QP3	malate synthase g
HFP99_RS09285	ENOG4108I9X	Isocitrate lyase
HFP99_RS09290	ENOG4108KZ1	Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity)
HFP99_RS09300	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HFP99_RS09305	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HFP99_RS09310	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HFP99_RS09320	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HFP99_RS09330	ENOG4105F1A	Pyruvate formate-lyase
HFP99_RS09340	ENOG4106YG3	ABC transporter
HFP99_RS09345	ENOG4105DSP	amino acid AbC transporter
HFP99_RS09350	ENOG4106PMH	Extracellular solute-binding protein family 3
HFP99_RS09355	ENOG4108JEH	abc transporter atp-binding protein
HFP99_RS09365	ENOG4105DYB	Isoaspartyl dipeptidase
HFP99_RS09370	ENOG4108ZYK	Acyl carrier protein phosphodiesterase
HFP99_RS09380	ENOG4105K89	arsenate reductase
HFP99_RS09390	ENOG4105ERG	peptidase m48, ste24p
HFP99_RS09395	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
HFP99_RS09415	ENOG4105CSR	polyphosphate kinase 2
HFP99_RS09425	ENOG4105E89	ABC transporter
HFP99_RS09435	ENOG4108IJ9	(ABC) transporter
HFP99_RS09445	ENOG4105D56	permease protein
HFP99_RS09450	ENOG4107FKK	extracellular solute-binding protein family 1
HFP99_RS09455	ENOG4106V8H	Nucleoid-associated protein
HFP99_RS09460	ENOG4105PAN	UPF0352 protein
HFP99_RS09465	ENOG4105E68	Sulfatase
HFP99_RS09470	ENOG4105D05	Receptor
HFP99_RS09475	ENOG4105CUG	Oligopeptidase b
HFP99_RS09495	ENOG4108QSZ	General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity)
HFP99_RS09500	ENOG4108WFC	UPF0438 protein yifE
HFP99_RS09515	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HFP99_RS09520	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
HFP99_RS09525	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HFP99_RS09530	ENOG4105E98	transcriptional regulator DeoR family
HFP99_RS09535	ENOG4105CXY	transporter
HFP99_RS09540	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HFP99_RS09545	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HFP99_RS09550	ENOG4105HEI	LysR family (Transcriptional regulator
HFP99_RS09575	ENOG4105CV8	reductase
HFP99_RS09580	ENOG4105F27	Major Facilitator
HFP99_RS09590	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HFP99_RS09595	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HFP99_RS09600	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HFP99_RS09605	ENOG4108Q2J	Inner membrane protein YebE
HFP99_RS09625	ENOG4106428	Protein of unknown function (DUF2496)
HFP99_RS09645	ENOG4105DJ2	Major Facilitator Superfamily
HFP99_RS09650	ENOG4105FE9	pseudouridine synthase
HFP99_RS09655	ENOG4105D82	Glutamate dehydrogenase
HFP99_RS09665	ENOG4105I9P	Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity)
HFP99_RS09675	ENOG4108R4U	Hnh endonuclease
HFP99_RS09680	ENOG4105BZU	Histidine kinase
HFP99_RS09690	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
HFP99_RS09695	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HFP99_RS09720	ENOG4108YYC	ycei family
HFP99_RS09725	ENOG4105CC0	LysR family Transcriptional regulator
HFP99_RS09735	ENOG4105CKU	formyltetrahydrofolate synthetase
HFP99_RS09745	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_RS09750	ENOG4105EUJ	GTP cyclohydrolase i
HFP99_RS09755	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HFP99_RS09760	ENOG4105D06	uba thif-type nad fad binding protein
HFP99_RS09775	ENOG410832A	alpha/beta hydrolase fold
HFP99_RS09780	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
HFP99_RS09785	ENOG4105E0C	molybdate abc transporter
HFP99_RS09790	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
HFP99_RS09795	ENOG4108ZAF	Molybdopterin
HFP99_RS09800	ENOG4105M00	molybdopterin converting factor, subunit 1
HFP99_RS09805	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HFP99_RS09810	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HFP99_RS09815	ENOG4105CUW	cytochrome C-TYPE protein
HFP99_RS09825	ENOG4105GXZ	Ferredoxin-type protein NapH
HFP99_RS09830	ENOG4108BGM	Quinol dehydrogenase periplasmic component
HFP99_RS09835	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HFP99_RS09850	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HFP99_RS09855	ENOG4105BZU	Histidine kinase
HFP99_RS09860	ENOG4105WH1	Two component transcriptional regulator luxr family
HFP99_RS09875	ENOG4105BZU	Histidine kinase
HFP99_RS09885	ENOG4105CHW	UPF0052 protein
HFP99_RS09895	ENOG4105E7A	Glutamine amidotransferase
HFP99_RS09900	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HFP99_RS09905	ENOG4107QPN	acyl-Coa dehydrogenase
HFP99_RS09910	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HFP99_RS09920	ENOG4107RZZ	dna polymerase iii epsilon subunit
HFP99_RS09925	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HFP99_RS09930	ENOG4105D1A	Methyltransferase
HFP99_RS09935	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HFP99_RS09940	ENOG4105E9H	Lytic Murein transglycosylase
HFP99_RS09955	ENOG4105NAU	thioesterase Superfamily protein
HFP99_RS09965	ENOG41060NJ	transcriptional regulator
HFP99_RS09970	ENOG4107SC1	transglycosylase
HFP99_RS09975	ENOG4105BZU	Histidine kinase
HFP99_RS09980	ENOG4108WPH	sigma 54 modulation protein ribosomal protein S30EA
HFP99_RS10005	ENOG4105CFU	surface antigen
HFP99_RS10015	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
HFP99_RS10025	ENOG4107ZN8	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
HFP99_RS10035	ENOG4105VNH	ABC transporter solute-binding protein
HFP99_RS10045	ENOG4108VGW	abc transporter atp-binding protein
HFP99_RS10050	ENOG4108T9J	Cdp-alcohol phosphatidyltransferase
HFP99_RS10055	ENOG4105CVE	Lytic murein transglycosylase
HFP99_RS10070	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
HFP99_RS10075	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
HFP99_RS10080	ENOG4105EV9	Alpha Beta Hydrolase
HFP99_RS10090	ENOG4105NNH	LexA regulated protein
HFP99_RS10095	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
HFP99_RS10105	ENOG41090R7	Ferric uptake
HFP99_RS10110	ENOG4105CX6	glutaminyL-tRNA synthetase
HFP99_RS10120	ENOG4105C7W	Xanthine dehydrogenase
HFP99_RS10125	ENOG4108XHQ	(2Fe-2S)-binding domain protein
HFP99_RS10130	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
HFP99_RS10150	ENOG4108JJA	ABC, transporter
HFP99_RS10175	ENOG4107R0E	Glycosyl transferase, family 2
HFP99_RS10205	ENOG4105E2D	ec 3.2.1.52
HFP99_RS10210	ENOG4105CI1	PTS System
HFP99_RS10215	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HFP99_RS10220	ENOG4105CE4	GlcNAc 6-P deacetylase
HFP99_RS10225	ENOG4105E2R	ROK family
HFP99_RS10230	ENOG4105DIJ	Phosphoethanolamine transferase
HFP99_RS10235	ENOG4105CDY	transcriptional regulatory protein
HFP99_RS10240	ENOG4105C9M	aspartyl-trna synthetase
HFP99_RS10250	ENOG41081XQ	Conserved Protein
HFP99_RS10255	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
HFP99_RS10260	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
HFP99_RS10280	ENOG4105C5Q	Transcriptional regulator
HFP99_RS10285	ENOG4107TT5	NLP P60 protein
HFP99_RS10295	ENOG4107RGH	Aldehyde dehydrogenase
HFP99_RS10300	ENOG4107Z3H	Transcriptional regulator, TetR family
HFP99_RS10315	ENOG4105C6T	cysteine synthase
HFP99_RS10335	ENOG4105UQX	Mate efflux family protein
HFP99_RS10345	ENOG4105Z2P	Protein of unknown function (DUF465)
HFP99_RS10350	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
HFP99_RS10360	ENOG4105QVC	MOSC domain-containing protein
HFP99_RS10360	ENOG4105QVC	MOSC domain-containing protein
HFP99_RS10365	ENOG4105D0M	Protease HtpX homolog
HFP99_RS10370	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HFP99_RS10375	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HFP99_RS10380	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HFP99_RS10385	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HFP99_RS10390	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HFP99_RS10405	ENOG4105C5S	asparaginyl-tRNA synthetase
HFP99_RS10410	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
HFP99_RS10425	ENOG4105CEE	C4-dicarboxylate transporter
HFP99_RS10435	ENOG4105KUZ	arsenate reductase
HFP99_RS10440	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HFP99_RS10455	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
HFP99_RS10465	ENOG410829K	Lysine exporter protein (Lyse ygga)
HFP99_RS10475	ENOG4105RX8	Protein of unknown function (DUF1523)
HFP99_RS10490	ENOG4105DU0	nucleoside hydrolase
HFP99_RS10495	ENOG4105D3G	Pseudouridine synthase
HFP99_RS10500	ENOG4107SXA	Phosphorylase
HFP99_RS10505	ENOG4105C0A	alcohol dehydrogenase
HFP99_RS10510	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HFP99_RS10515	ENOG4105K4T	epimerase
HFP99_RS10520	ENOG4105VDB	UPF0125 protein
HFP99_RS10525	ENOG4108Z1B	Cyclase dehydrase
HFP99_RS10530	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HFP99_RS10540	ENOG4105DFP	Integrase
HFP99_RS10580	ENOG4105CVR	type I restriction-modification system
HFP99_RS10595	ENOG4108YYD	acetyltransferase
HFP99_RS10620	ENOG4107R11	Transcriptional regulator
HFP99_RS10625	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HFP99_RS10645	ENOG4105M2J	Glutaredoxin
HFP99_RS10650	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HFP99_RS10655	ENOG410903C	(LipO)protein
HFP99_RS10665	ENOG4105KWW	Biogenesis protein
HFP99_RS10670	ENOG4107QX9	Thiol disulfide interChange protein
HFP99_RS10675	ENOG4105DA4	cytochrome c-type biogenesis protein
HFP99_RS10680	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
HFP99_RS10685	ENOG4105X3C	heme exporter protein
HFP99_RS10690	ENOG41060IM	Heme exporter protein
HFP99_RS10695	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
HFP99_RS10710	ENOG4108V3W	Chemotaxis protein, CheW
HFP99_RS10720	ENOG4107QJE	Chromosome Partitioning Protein
HFP99_RS10725	ENOG4108SEK	ompa motb domain protein
HFP99_RS10730	ENOG4105E14	MotA TolQ exbB proton channel
HFP99_RS10735	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HFP99_RS10750	ENOG4108VYJ	response regulator receiver protein
HFP99_RS10755	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HFP99_RS10765	ENOG4105FZW	flagellar biosynthesis regulator FlhF
HFP99_RS10770	ENOG4105D7B	Flagellar biosynthesis protein flha
HFP99_RS10775	ENOG4105D00	flagellar biosynthetic protein flhB
HFP99_RS10780	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
HFP99_RS10785	ENOG4105VS8	Flagellar biosynthetic protein fliq
HFP99_RS10790	ENOG4105CN7	Flagellar biosynthetic protein FliP
HFP99_RS10795	ENOG4105VTB	flagellar biosynthesis protein fliO
HFP99_RS10800	ENOG4105DD5	Flagellar motor switch protein
HFP99_RS10805	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HFP99_RS10825	ENOG4108JIR	Flagellum-specific ATP synthase
HFP99_RS10835	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HFP99_RS10840	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HFP99_RS10845	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
HFP99_RS10860	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HFP99_RS10885	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HFP99_RS10895	ENOG4108JQ7	(ABC) transporter
HFP99_RS10905	ENOG4105RD7	BadF BadG BcrA BcrD
HFP99_RS10910	ENOG4105E2D	ec 3.2.1.52
HFP99_RS10915	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
HFP99_RS10930	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HFP99_RS10935	ENOG4105EY2	Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity)
HFP99_RS10940	ENOG4105ERU	peptidase
HFP99_RS10945	ENOG4105UBK	short-chain dehydrogenase reductase
HFP99_RS10950	ENOG4105C5Q	Transcriptional regulator
HFP99_RS10960	ENOG4105C87	Aminotransferase class I and II
HFP99_RS10975	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HFP99_RS11005	ENOG4105F6U	Short-chain dehydrogenase reductase Sdr
HFP99_RS11010	ENOG4105HEI	LysR family (Transcriptional regulator
HFP99_RS11030	ENOG4105N2G	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HFP99_RS11035	ENOG4105NQG	DoxX
HFP99_RS11045	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
HFP99_RS11060	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
HFP99_RS11065	ENOG4107TT5	NLP P60 protein
HFP99_RS11070	ENOG4107YAK	holo-(acyl carrier protein) synthase 2
HFP99_RS11075	ENOG4107QR8	Thioredoxin
HFP99_RS11085	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HFP99_RS11090	ENOG4105CIY	formyltetrahydrofolate deformylase
HFP99_RS11115	ENOG4105E4C	Lytic transglycosylase catalytic
HFP99_RS11125	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HFP99_RS11130	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HFP99_RS11135	ENOG4105EP9	oxidoreductase
HFP99_RS11160	ENOG4108UK5	Transposase
HFP99_RS11170	ENOG4105CCT	upf0313 protein
HFP99_RS11180	ENOG4105BZS	acriflavin resistance protein
HFP99_RS11190	ENOG4106TD9	Diguanylate cyclase
HFP99_RS11195	ENOG4105D78	K07001 NTE family protein
HFP99_RS11200	ENOG4105C8J	)-transporter
HFP99_RS11215	ENOG4105UYK	outer membrane protein a
HFP99_RS11220	ENOG4105UYK	outer membrane protein a
HFP99_RS11225	ENOG4105UYK	outer membrane protein a
HFP99_RS11230	ENOG4107R1I	NAD-dependent malic enzyme
HFP99_RS11235	ENOG41075H3	AraC family transcriptional regulator
HFP99_RS11240	ENOG4105UQX	Mate efflux family protein
HFP99_RS11245	ENOG4105RKX	Protein of unknown function (DUF2498)
HFP99_RS11255	ENOG4105C2W	permease
HFP99_RS11260	ENOG4108KMH	lipoate-protein ligase a
HFP99_RS11265	ENOG4105BZG	amino acid carrier protein
HFP99_RS11285	ENOG4105PTV	Nudix Hydrolase
HFP99_RS11295	ENOG4105CDA	abc transporter atp-binding protein
HFP99_RS11300	ENOG4105DRP	amino acid AbC transporter
HFP99_RS11305	ENOG4105EZ7	amino acid ABC transporter
HFP99_RS11325	ENOG4105CJ1	ABC, transporter
HFP99_RS11330	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HFP99_RS11335	ENOG4106N3A	copper homeostasis protein cutc
HFP99_RS11350	ENOG4105ERG	peptidase m48, ste24p
HFP99_RS11355	ENOG4105DJH	phosphate
HFP99_RS11360	ENOG4105BZU	Histidine kinase
HFP99_RS11365	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HFP99_RS11370	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HFP99_RS11375	ENOG4105BZU	Histidine kinase
HFP99_RS11385	ENOG4105C26	Dehydrogenase
HFP99_RS11395	ENOG4108IPJ	Membrane
HFP99_RS11400	ENOG4106YYS	transcriptional regulatory protein
HFP99_RS11410	ENOG4107R1I	NAD-dependent malic enzyme
HFP99_RS11415	ENOG4105D2K	citrate carrier protein
HFP99_RS11420	ENOG4108US0	Transcription regulator that can specifically activate or repress expression of target genes (By similarity)
HFP99_RS11425	ENOG4105J12	Multidrug resistance protein mdtN
HFP99_RS11455	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
HFP99_RS11460	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
HFP99_RS11470	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HFP99_RS11480	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HFP99_RS11485	ENOG4105EXN	Sulfate transport protein CysZ
HFP99_RS11490	ENOG4105EN6	Membrane
HFP99_RS11500	ENOG4105EAQ	(twin-arginine translocation) pathway signal
HFP99_RS11505	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
HFP99_RS11535	ENOG4107T9C	Alpha amylase catalytic region
HFP99_RS11570	ENOG4105BZU	Histidine kinase
HFP99_RS11575	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HFP99_RS11580	ENOG4105C9K	Endothelin-converting enzyme 1
HFP99_RS11590	ENOG4105C5H	ABC transporter
HFP99_RS11600	ENOG4105DVH	amino acid
HFP99_RS11605	ENOG4105C44	Serine transporter
HFP99_RS11610	ENOG410642W	LysR family Transcriptional regulator
HFP99_RS11640	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HFP99_RS11645	ENOG4105C0B	DNA polymerase III (alpha subunit)
HFP99_RS11650	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HFP99_RS11655	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HFP99_RS11660	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HFP99_RS11665	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HFP99_RS11670	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HFP99_RS11675	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
HFP99_RS11685	ENOG4105DZP	Membrane-associated zinc metalloprotease
HFP99_RS11690	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HFP99_RS11695	ENOG4105KNE	Phosphatidate cytidylyltransferase
HFP99_RS11705	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HFP99_RS11710	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HFP99_RS11715	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HFP99_RS11720	ENOG4105CE9	30S ribosomal protein S2
HFP99_RS11725	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HFP99_RS11730	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
HFP99_RS11735	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
HFP99_RS11740	ENOG4108T8E	UPF0325 protein
HFP99_RS11745	ENOG4105CI1	PTS System
HFP99_RS11750	ENOG4107W52	maltose operon periplasmic protein
HFP99_RS11755	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
HFP99_RS11760	ENOG4105QDK	Flavodoxin
HFP99_RS11765	ENOG4105DR9	pseudouridine synthase
HFP99_RS11770	ENOG4105WP7	tRNA pseudouridine synthase C
HFP99_RS11795	ENOG4105EXF	Zn-ribbon-containing, possibly nucleic-acid-binding protein
HFP99_RS11800	ENOG4108T6E	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)
HFP99_RS11805	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
HFP99_RS11820	ENOG4105EWT	decarboxylase family
HFP99_RS11825	ENOG4105CIQ	May have a role in processing of nucleic acids. It is probably not an exonuclease
HFP99_RS11830	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HFP99_RS11840	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
HFP99_RS11845	ENOG4105M08	Membrane
HFP99_RS11855	ENOG4105ETT	transcriptional Regulator, LysR family
HFP99_RS11860	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_RS11865	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HFP99_RS11880	ENOG4105CJ2	(LipO)protein
HFP99_RS11885	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
HFP99_RS11890	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HFP99_RS11895	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HFP99_RS11900	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HFP99_RS11905	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HFP99_RS11910	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HFP99_RS11915	ENOG4105M85	Bola protein
HFP99_RS11930	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HFP99_RS11940	ENOG4105EYM	Major Facilitator superfamily
HFP99_RS11950	ENOG4108VPT	UPF0234 protein
HFP99_RS11955	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HFP99_RS11960	ENOG4107S0N	DJ-1 family
HFP99_RS11985	ENOG4105CS6	Rhs element vgr protein
HFP99_RS11990	ENOG4108WC9	type VI secretion system effector, hcp1 family
HFP99_RS11995	ENOG4105VJY	transcriptional regulator
HFP99_RS12000	ENOG4105CHH	sulfate transporter
HFP99_RS12005	ENOG4105K89	arsenate reductase
HFP99_RS12010	ENOG4105D6J	arsenicaL-resistance protein
HFP99_RS12060	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HFP99_RS12065	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HFP99_RS12070	ENOG4105BZS	acriflavin resistance protein
HFP99_RS12090	ENOG4105CMR	udp-glucose 4-epimerase
HFP99_RS12095	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HFP99_RS12100	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
HFP99_RS12105	ENOG4108RMU	ferritin dps family protein
HFP99_RS12130	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HFP99_RS12145	ENOG4107FW0	short-chain dehydrogenase reductase
HFP99_RS12155	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HFP99_RS12160	ENOG4108XDN	Transcriptional regulator
HFP99_RS12165	ENOG4107SEY	Conserved Protein
HFP99_RS12190	ENOG4105CQC	Prephenate dehydratase
HFP99_RS12230	ENOG4107RDJ	Sulfotransferase
HFP99_RS12255	ENOG4105D8V	Glucose sorbosone dehydrogenase
HFP99_RS12265	ENOG4105MVE	transcriptional regulator
HFP99_RS12275	ENOG4105G63	Type III effector Hrp-dependent
HFP99_RS12280	ENOG4105FB2	class II Aldolase
HFP99_RS12285	ENOG4105QG4	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
HFP99_RS12290	ENOG4105EXW	epimerase dehydratase
HFP99_RS12295	ENOG4105C6Z	Gluconate
HFP99_RS12305	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_RS12315	ENOG4105E1F	short-chain dehydrogenase reductase
HFP99_RS12340	ENOG4105CTD	carboxy-peptidase
HFP99_RS12360	ENOG4105XDF	Protein of unknown function (DUF1272)
HFP99_RS12370	ENOG4105CFP	Peptidase U32
HFP99_RS12375	ENOG4105N14	lysine exporter protein LysE YggA
HFP99_RS12385	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HFP99_RS12410	ENOG4105BZU	Histidine kinase
HFP99_RS12415	ENOG41068CG	regulatoR
HFP99_RS12440	ENOG4108NJZ	Sensory box GGDEF EAL domain protein
HFP99_RS12450	ENOG4105DB1	molybdopterin oxidoreductase
HFP99_RS12455	ENOG4106WHD	Tetrathionate reductase
HFP99_RS12460	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
HFP99_RS12465	ENOG4105BZU	Histidine kinase
HFP99_RS12470	ENOG4108ZXC	Two component transcriptional regulator, luxr family
HFP99_RS12475	ENOG4105EQ6	Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity)
HFP99_RS12480	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HFP99_RS12485	ENOG4105CW7	secretion protein, HlyD family
HFP99_RS12505	ENOG4105C26	Dehydrogenase
HFP99_RS12510	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HFP99_RS12515	ENOG4105CDU	Replicative dna helicase
HFP99_RS12525	ENOG4105CGH	5'-nucleotidase
HFP99_RS12550	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HFP99_RS12565	ENOG4108YZY	peptidylprolyl cis-trans isomerase
HFP99_RS12570	ENOG4105VKU	nucleicacid-binding protein
HFP99_RS12585	ENOG4105DNZ	Alpha Beta Hydrolase
HFP99_RS12595	ENOG4105YP7	UPF0270 protein
HFP99_RS12600	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
HFP99_RS12615	ENOG4108UKZ	OsmC family
HFP99_RS12620	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
HFP99_RS12635	ENOG4105BZU	Histidine kinase
HFP99_RS12640	ENOG4105D8G	Major Facilitator superfamily
HFP99_RS12665	ENOG4105PYN	Pyridoxamine 5-phosphate oxidase-related
HFP99_RS12670	ENOG41090JE	Utilization Protein
HFP99_RS12680	ENOG4105EHG	Permease protein
HFP99_RS12695	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HFP99_RS12705	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
HFP99_RS12715	ENOG4105CKK	Glycosyl transferase, family 2
HFP99_RS12720	ENOG4105E4C	Lytic transglycosylase catalytic
HFP99_RS12725	ENOG4105C5H	ABC transporter
HFP99_RS12735	ENOG4105C7N	Xanthine uracil vitamin C permease
HFP99_RS12740	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
HFP99_RS12745	ENOG4108S0S	Nucleotidyl transferase
HFP99_RS12750	ENOG4105EHM	Aminoglycoside phosphotransferase
HFP99_RS12755	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
HFP99_RS12765	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HFP99_RS12770	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HFP99_RS12780	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HFP99_RS12790	ENOG4105DEN	Luciferase family
HFP99_RS12795	ENOG4105DHT	Metal Dependent Phosphohydrolase
HFP99_RS12800	ENOG4105DWD	nucleoside recognition domain protein
HFP99_RS12805	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HFP99_RS12810	ENOG4105K46	50S ribosomal protein l27
HFP99_RS12815	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HFP99_RS12820	ENOG4105EAH	synthase
HFP99_RS12830	ENOG4105EPW	hflc protein
HFP99_RS12835	ENOG4107QJR	hflk protein
HFP99_RS12840	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HFP99_RS12845	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
HFP99_RS12850	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HFP99_RS12855	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HFP99_RS12860	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HFP99_RS12865	ENOG4105K8N	protein family UPF0079, ATPase
HFP99_RS12870	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HFP99_RS12890	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HFP99_RS12895	ENOG4108UMI	ABC transporter, permease
HFP99_RS12900	ENOG4105D01	(LipO)protein
HFP99_RS12905	ENOG4105MDZ	Transcriptional activator rfaH
HFP99_RS12910	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_RS12915	ENOG4105BZU	Histidine kinase
HFP99_RS12930	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HFP99_RS12935	ENOG4105BZU	Histidine kinase
HFP99_RS12960	ENOG4105EXG	Transcriptional regulator
HFP99_RS12970	ENOG4107QWK	SAICAR synthetase
HFP99_RS12975	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HFP99_RS12980	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HFP99_RS12985	ENOG4105RH4	Glycine cleavage system transcriptional repressor
HFP99_RS12990	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HFP99_RS13000	ENOG4105XWI	UPF0304 protein
HFP99_RS13010	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HFP99_RS13015	ENOG4105C6K	Malic enzyme
HFP99_RS13020	ENOG4108ZP8	Acetolactate synthase small subunit
HFP99_RS13025	ENOG4105C7K	acetolactate synthase
HFP99_RS13035	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HFP99_RS13040	ENOG4105YVM	Phosphoesterase, PA-phosphatase related
HFP99_RS13050	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HFP99_RS13060	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HFP99_RS13065	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HFP99_RS13080	ENOG4105DP9	ABC transporter
HFP99_RS13085	ENOG4106SMU	thiamine transporter membrane protein
HFP99_RS13090	ENOG4107T0D	ABC, transporter
HFP99_RS13095	ENOG4108IAB	Phoh family
HFP99_RS13135	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HFP99_RS13145	ENOG4105CMQ	Chloride channel
HFP99_RS13150	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HFP99_RS13165	ENOG41076MN	Phosphoesterase, PA-phosphatase related
HFP99_RS13180	ENOG41090TI	Catalyzes the excretion of spermidine (By similarity)
HFP99_RS13185	ENOG4108ZBZ	Catalyzes the excretion of spermidine (By similarity)
HFP99_RS13190	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
HFP99_RS13195	ENOG4105BZ4	penicillin-binding protein
HFP99_RS13200	ENOG4105CQ7	ATP-dependent helicase
HFP99_RS13210	ENOG4105PW4	Sugar fermentation stimulation protein homolog
HFP99_RS13220	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
HFP99_RS13225	ENOG4105DJ0	Poly(A) Polymerase
HFP99_RS13230	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HFP99_RS13235	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HFP99_RS13240	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HFP99_RS13250	ENOG4105E3A	(ABC) transporter
HFP99_RS13255	ENOG4105DA5	(ABC) transporter
HFP99_RS13260	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HFP99_RS13265	ENOG410630P	Transcriptional regulator
HFP99_RS13270	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
HFP99_RS13275	ENOG4105DFU	Cell wall formation (By similarity)
HFP99_RS13280	ENOG4105F0N	pyrophosphate phospho-hydrolase
HFP99_RS13295	ENOG4108UUE	Transcriptional regulator
HFP99_RS13310	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HFP99_RS13340	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
HFP99_RS13350	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
HFP99_RS13355	ENOG4105C11	sulfate adenylyltransferase), subunit 2
HFP99_RS13360	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HFP99_RS13365	ENOG4107QX8	SPFH domain, Band 7 family protein
HFP99_RS13370	ENOG4105G5H	Membrane
HFP99_RS13380	ENOG4105D9R	oxidoreductase
HFP99_RS13390	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HFP99_RS13395	ENOG4105CSA	Coproporphyrinogen iii oxidase
HFP99_RS13400	ENOG4105VCN	Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system
HFP99_RS13415	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HFP99_RS13420	ENOG4105C12	Phosphoribosylglycinamide synthetase
HFP99_RS13450	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HFP99_RS13455	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HFP99_RS13460	ENOG4105KTH	gatB Yqey
HFP99_RS13465	ENOG4105VCC	30S ribosomal protein S21
HFP99_RS13470	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HFP99_RS13480	ENOG4108K5P	(LipO)protein
HFP99_RS13490	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HFP99_RS13495	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HFP99_RS13500	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
HFP99_RS13505	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HFP99_RS13510	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HFP99_RS13515	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
HFP99_RS13520	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HFP99_RS13525	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HFP99_RS13530	ENOG4105DXN	mazG family
HFP99_RS13535	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HFP99_RS13540	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HFP99_RS13545	ENOG4105BZU	Histidine kinase
HFP99_RS13550	ENOG4108W15	Protein of unknown function (DUF1456)
HFP99_RS13555	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
HFP99_RS13560	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HFP99_RS13565	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
HFP99_RS13580	ENOG4105C3F	Signal peptidase i
HFP99_RS13585	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HFP99_RS13605	ENOG4105EMN	RNA polymerase sigma factor
HFP99_RS13610	ENOG4108IYU	L-aspartate oxidase
HFP99_RS13650	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
HFP99_RS13660	ENOG4105CJP	fad dependent oxidoreductase
HFP99_RS13665	ENOG4105D2N	Aldolase
HFP99_RS13670	ENOG4105BZA	Phosphoglycerate kinase
HFP99_RS13675	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HFP99_RS13680	ENOG4105DKQ	ROK family
HFP99_RS13685	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HFP99_RS13695	ENOG4106MWK	domain protein
HFP99_RS13700	ENOG4105EYW	Ion transport protein
HFP99_RS13705	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_RS13715	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HFP99_RS13725	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
HFP99_RS13740	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
HFP99_RS13745	ENOG4105DRP	amino acid AbC transporter
HFP99_RS13750	ENOG4105E5Q	amino acid AbC transporter
HFP99_RS13760	ENOG4105CT1	(ABC) transporter
HFP99_RS13765	ENOG4107PU6	Membrane
HFP99_RS13770	ENOG4108UW5	maltose o-acetyltransferase
HFP99_RS13795	ENOG41090U3	tautomerase
HFP99_RS13805	ENOG4107NQ8	LysR family Transcriptional regulator
HFP99_RS13810	ENOG4105CH7	arginosuccinase
HFP99_RS13815	ENOG4105CDH	Citrulline--aspartate ligase
HFP99_RS13825	ENOG4105CAS	nag kinase
HFP99_RS13830	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HFP99_RS13840	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HFP99_RS13845	ENOG4105BZU	Histidine kinase
HFP99_RS13850	ENOG4108Z66	YbaK ebsC protein
HFP99_RS13880	ENOG4105CMU	LysR family (Transcriptional regulator
HFP99_RS13890	ENOG41067MG	lrgb family
HFP99_RS13895	ENOG4105CFH	Aspartokinase
HFP99_RS13900	ENOG4105C28	cystathionine
HFP99_RS13905	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
HFP99_RS13915	ENOG4108Z7R	Chaperone CsaA
HFP99_RS13920	ENOG4105C44	Serine transporter
HFP99_RS13925	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
HFP99_RS13930	ENOG4107RK2	ADP-ribose diphosphatase NudE
HFP99_RS13935	ENOG4107Y3D	HAD-superfamily hydrolase subfamily IA variant 3
HFP99_RS13940	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HFP99_RS13945	ENOG4108UDW	Transcriptional regulator, luxr family
HFP99_RS13955	ENOG4105F8D	glycoside hydrolase family 4
HFP99_RS13960	ENOG4105EZV	Transcriptional regulator
HFP99_RS13965	ENOG4105VCP	PTS System
HFP99_RS13970	ENOG4105CS2	ec 3.2.1.21
HFP99_RS13975	ENOG4105CK1	PTS System
HFP99_RS13980	ENOG4105VZJ	PTS System
HFP99_RS14025	ENOG4108VAU	general secretion pathway protein G
HFP99_RS14030	ENOG4105D7Q	type ii secretion system
HFP99_RS14035	ENOG4107QHF	type ii secretion system protein e
HFP99_RS14050	ENOG4105VEJ	Heat shock protein
HFP99_RS14055	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
HFP99_RS14060	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
HFP99_RS14080	ENOG4108XTF	Outer Membrane Lipoprotein
HFP99_RS14085	ENOG4105I7R	Adenylate cyclase
HFP99_RS14090	ENOG4107IX6	phosphate transport regulator
HFP99_RS14095	ENOG4105CJ3	phosphate transporter
HFP99_RS14100	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HFP99_RS14120	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
HFP99_RS14125	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
HFP99_RS14145	ENOG4108Q2G	(LipO)protein
HFP99_RS14150	ENOG4105DY2	Paraquat-inducible protein b
HFP99_RS14155	ENOG4105F1S	paraquat-inducible protein a
HFP99_RS14160	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
HFP99_RS14165	ENOG4107VXZ	Hydrolase
HFP99_RS14175	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HFP99_RS14180	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HFP99_RS14185	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HFP99_RS14190	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HFP99_RS14230	ENOG4105DFD	Na H antiporter
HFP99_RS14235	ENOG4108M0I	Transcriptional regulator
HFP99_RS14240	ENOG4107TYH	extracellular solute-binding protein family 1
HFP99_RS14245	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HFP99_RS14250	ENOG4105D81	ABC transporter, permease
HFP99_RS14255	ENOG4105NRK	Binding-protein-dependent transport systems, inner membrane component
HFP99_RS14260	ENOG4105C26	Dehydrogenase
HFP99_RS14265	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HFP99_RS14270	ENOG4107VFP	cytochrome oxidase assembly
HFP99_RS14290	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
HFP99_RS14295	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
HFP99_RS14310	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
HFP99_RS14325	ENOG4108UQY	Iron-storage protein
HFP99_RS14330	ENOG4108Z5K	methylglyoxal synthase
HFP99_RS14345	ENOG4105HDK	L-asparaginase
HFP99_RS14355	ENOG4105DDV	Transcriptional regulator (LacI family
HFP99_RS14365	ENOG4105DKQ	ROK family
HFP99_RS14370	ENOG4105VCP	PTS System
HFP99_RS14375	ENOG4105CS2	ec 3.2.1.21
HFP99_RS14380	ENOG4105CK1	PTS System
HFP99_RS14385	ENOG4105VZJ	PTS System
HFP99_RS14390	ENOG4105CK1	PTS System
HFP99_RS14405	ENOG4105D4X	repressor
HFP99_RS14410	ENOG4105C5Y	PTS System
HFP99_RS14415	ENOG4105CG3	alpha amylase, catalytic region
HFP99_RS14420	ENOG4108UW5	maltose o-acetyltransferase
HFP99_RS14430	ENOG4107AQZ	Membrane
HFP99_RS14450	ENOG4105UYK	outer membrane protein a
HFP99_RS14475	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HFP99_RS14480	ENOG4107ZVW	dihydroneopterin aldolase
HFP99_RS14485	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HFP99_RS14495	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HFP99_RS14500	ENOG4105CKI	cobalamin synthesis protein
HFP99_RS14510	ENOG4105E82	cytochrome subunit of dehydrogenase
HFP99_RS14520	ENOG4105HEI	LysR family (Transcriptional regulator
HFP99_RS14525	ENOG4105F6U	Short-chain dehydrogenase reductase Sdr
HFP99_RS14530	ENOG4105BZU	Histidine kinase
HFP99_RS14535	ENOG4105BZU	Histidine kinase
HFP99_RS14540	ENOG4107QIJ	Aconitate hydratase 2
HFP99_RS14550	ENOG41069D7	Methyl-accepting chemotaxis
HFP99_RS14555	ENOG4108N3W	hemolysin secretion protein
HFP99_RS14570	ENOG4107QN2	dihydrolipoyl dehydrogenase
HFP99_RS14575	ENOG4107QSN	dihydrolipoamide acetyltransferase
HFP99_RS14580	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
HFP99_RS14585	ENOG41073TP	transcriptional regulator
HFP99_RS14600	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HFP99_RS14610	ENOG4107QHF	type ii secretion system protein e
HFP99_RS14615	ENOG4105D7Q	type ii secretion system
HFP99_RS14630	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
HFP99_RS14635	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
HFP99_RS14640	ENOG4105M6F	mutator MutT protein
HFP99_RS14645	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HFP99_RS14655	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HFP99_RS14660	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HFP99_RS14665	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HFP99_RS14670	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
HFP99_RS14675	ENOG4105DFU	Cell wall formation (By similarity)
HFP99_RS14680	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HFP99_RS14685	ENOG4105CNI	cell division protein FtsW
HFP99_RS14690	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HFP99_RS14695	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HFP99_RS14700	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
HFP99_RS14705	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HFP99_RS14710	ENOG4105CJN	penicillin-binding protein
HFP99_RS14715	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
HFP99_RS14720	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HFP99_RS14725	ENOG4108V6E	Cell division protein mraZ
HFP99_RS14735	ENOG4105E9H	Lytic Murein transglycosylase
HFP99_RS14745	ENOG4105ER2	Ompa motb domain protein
HFP99_RS14750	ENOG4107RD7	Flagellar Motor Protein, MotA
HFP99_RS14775	ENOG4105MQ3	flagellar protein FliS
HFP99_RS14780	ENOG410804A	Flagellar hook-associated 2 domain-containing protein
HFP99_RS14785	ENOG4105I03	Flagellin
HFP99_RS14790	ENOG4105I03	Flagellin
HFP99_RS14795	ENOG4108C80	FliB family
HFP99_RS14805	ENOG4105DTJ	flagellar hook-associated protein
HFP99_RS14810	ENOG4105E1Q	flagellar hook-associated protein
HFP99_RS14820	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HFP99_RS14825	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HFP99_RS14830	ENOG4105CGA	flagellar basal-body rod protein FlgG
HFP99_RS14835	ENOG4108KPB	Flagellar basal-body rod protein FlgF
HFP99_RS14840	ENOG4105BZE	flagellar hook protein, FlgE
HFP99_RS14845	ENOG4105W00	Flagellar hook capping protein
HFP99_RS14850	ENOG4108ZC9	flagellar basal-body rod protein flgc
HFP99_RS14855	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
HFP99_RS14865	ENOG4105M9M	anti-sigma28 factor FlgM
HFP99_RS14880	ENOG4108JIR	Flagellum-specific ATP synthase
HFP99_RS14890	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HFP99_RS14895	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HFP99_RS14900	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
HFP99_RS14915	ENOG4105D00	flagellar biosynthetic protein flhB
HFP99_RS14920	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
HFP99_RS14925	ENOG4105VS8	Flagellar biosynthetic protein fliq
HFP99_RS14930	ENOG4105CN7	Flagellar biosynthetic protein FliP
HFP99_RS14935	ENOG4105DD5	Flagellar motor switch protein
HFP99_RS14950	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HFP99_RS14955	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
HFP99_RS14960	ENOG41082RQ	UPF0102 protein
HFP99_RS14965	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HFP99_RS14970	ENOG4105W4M	Transport-associated protein
HFP99_RS14975	ENOG4105KB2	stringent starvation protein b
HFP99_RS14980	ENOG4107MKT	Stringent starvation protein a
HFP99_RS14985	ENOG4105EIX	cytochrome c1
HFP99_RS14990	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HFP99_RS14995	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HFP99_RS15000	ENOG4108UJD	30S ribosomal protein S9
HFP99_RS15005	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HFP99_RS15010	ENOG4105D6Z	AFG1 family ATPase
HFP99_RS15020	ENOG4105C0H	protease
HFP99_RS15025	ENOG4105C0H	protease
HFP99_RS15055	ENOG41069H0	dihydroorotase EC 3.5.2.3
HFP99_RS15075	ENOG41080Z8	PHOSPHOCARRIER protein
HFP99_RS15080	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HFP99_RS15085	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
HFP99_RS15090	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
HFP99_RS15095	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HFP99_RS15100	ENOG4108IUZ	ABC transporter
HFP99_RS15105	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
HFP99_RS15110	ENOG4108P1K	Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity)
HFP99_RS15120	ENOG4105C2X	Arabinose 5-phosphate isomerase
HFP99_RS15125	ENOG4105DHJ	ABC, transporter
HFP99_RS15130	ENOG4105CY3	ABC transporter, permease
HFP99_RS15135	ENOG4107PE3	Mammalian cell entry related domain protein
HFP99_RS15140	ENOG4105E3I	toluene tolerance
HFP99_RS15150	ENOG4105VFK	BolA family
HFP99_RS15155	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HFP99_RS15165	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HFP99_RS15170	ENOG4105N42	UPF0307 protein
HFP99_RS15180	ENOG41090HJ	UPF0265 protein
HFP99_RS15210	ENOG4108JCI	Transcriptional regulator
HFP99_RS15215	ENOG4105DKK	Benzoate
HFP99_RS15225	ENOG4105SYT	Methylenetetrahydrofolate reductase
HFP99_RS15245	ENOG4105EIF	outer membrane protein W
HFP99_RS15250	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HFP99_RS15255	ENOG41086KC	Transcriptional regulator
HFP99_RS15260	ENOG4108UUM	single-stranded DNA-binding protein
HFP99_RS15275	ENOG4105VEQ	Cold shock protein
HFP99_RS15280	ENOG4105D05	Receptor
HFP99_RS15285	ENOG4105E0F	Histidine kinase
HFP99_RS15300	ENOG4108NVR	Methyl-accepting chemotaxis
HFP99_RS15310	ENOG4105BZU	Histidine kinase
HFP99_RS15315	ENOG4108YZA	Nitrogen regulatory protein pii
HFP99_RS15330	ENOG4105KHA	Glyoxalase Bleomycin resistance protein (Dioxygenase
HFP99_RS15340	ENOG4107QYX	exodeoxyribonuclease v alpha
HFP99_RS15345	ENOG4107QKA	exodeoxyribonuclease V beta
HFP99_RS15355	ENOG4108VBZ	doxx family
HFP99_RS15360	ENOG4105C2I	pirin domain protein
HFP99_RS15370	ENOG4105CWB	LysR family transcriptional Regulator
HFP99_RS15405	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HFP99_RS15415	ENOG4105BZU	Histidine kinase
HFP99_RS15430	ENOG4105CF7	AraC family transcriptional regulator
HFP99_RS15435	ENOG4105WCN	acetyltransferase
HFP99_RS15440	ENOG4105CH6	catalase
HFP99_RS15460	ENOG410841Q	phosphoesterase PA-phosphatase related protein
HFP99_RS15465	ENOG4105IPI	Membrane
HFP99_RS15475	ENOG4105DWY	Agmatine deiminase
HFP99_RS15485	ENOG4105DWY	Agmatine deiminase
HFP99_RS15490	ENOG4105ETT	transcriptional Regulator, LysR family
HFP99_RS15495	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
HFP99_RS15500	ENOG4105VDH	Dihydroxyacetone kinase
HFP99_RS15505	ENOG4108UTZ	Dihydroxyacetone kinase
HFP99_RS15510	ENOG4105CMT	Dihydroxyacetone kinase
HFP99_RS15515	ENOG4105C7N	Xanthine uracil vitamin C permease
HFP99_RS15520	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
HFP99_RS15550	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
HFP99_RS15555	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HFP99_RS15560	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HFP99_RS15565	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HFP99_RS15570	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HFP99_RS15575	ENOG4105YKK	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
HFP99_RS15590	ENOG4105KME	endoribonuclease L-psp
HFP99_RS15605	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HFP99_RS15610	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HFP99_RS15615	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HFP99_RS15620	ENOG4108VZM	50s ribosomal protein L10
HFP99_RS15625	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HFP99_RS15630	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HFP99_RS15635	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HFP99_RS15640	ENOG4105PM1	preprotein translocase subunit SecE
HFP99_RS15650	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HFP99_RS15665	ENOG4105CS9	pantothenic acid kinase
HFP99_RS15670	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HFP99_RS15675	ENOG4105D4A	Cell wall formation (By similarity)
HFP99_RS15680	ENOG4107ZYR	domain protein
HFP99_RS15690	ENOG4108IYH	Dna topoisomerase
HFP99_RS15695	ENOG4105CUW	cytochrome C-TYPE protein
HFP99_RS15700	ENOG4107QY8	reductase
HFP99_RS15710	ENOG4105IFJ	Histidine kinase
HFP99_RS15715	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HFP99_RS15735	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
HFP99_RS15740	ENOG4108UQ5	membrane protein YcdZ
HFP99_RS15745	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HFP99_RS15755	ENOG4107WP9	Histidine kinase
HFP99_RS15775	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HFP99_RS15790	ENOG4108VVK	transcriptional Regulator, AsnC
HFP99_RS15795	ENOG4105CU9	asparagine synthetase A
HFP99_RS15800	ENOG4108H5C	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HFP99_RS15805	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HFP99_RS15810	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HFP99_RS15815	ENOG4105C34	Pseudouridine synthase
HFP99_RS15820	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFP99_RS15830	ENOG4107R6U	sodium dicarboxylate symporter
HFP99_RS15835	ENOG4105CEM	UPF0597 protein
HFP99_RS15840	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HFP99_RS15845	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HFP99_RS15855	ENOG4105CF7	AraC family transcriptional regulator
HFP99_RS15860	ENOG4105QNF	Outer membrane lipoprotein
HFP99_RS15865	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_RS15880	ENOG4105CXT	aspartate transcarbamylase
HFP99_RS15885	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
HFP99_RS15890	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
HFP99_RS15895	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
HFP99_RS15900	ENOG4105DBV	ornithine carbamoyltransferase
HFP99_RS15905	ENOG4105C5B	carbamate kinase
HFP99_RS15925	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_RS15930	ENOG4108HWV	)-transporter
HFP99_RS15945	ENOG4105CNT	hydrolase family 2
HFP99_RS15950	ENOG41060NJ	transcriptional regulator
HFP99_RS15955	ENOG4105CMR	udp-glucose 4-epimerase
HFP99_RS15960	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
HFP99_RS15965	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HFP99_RS15970	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HFP99_RS15975	ENOG4105CPC	Aldo Keto reductase
HFP99_RS15980	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HFP99_RS15985	ENOG4108NIX	Factor ChrR
HFP99_RS15990	ENOG4105K6V	RNA polymerase
HFP99_RS16000	ENOG4105C75	arginyL-tRNA synthetase
HFP99_RS16010	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HFP99_RS16015	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HFP99_RS16020	ENOG4105C57	major facilitator superfamily
HFP99_RS16035	ENOG4105D0S	secretion protein (HlyD
HFP99_RS16040	ENOG4105CJ1	ABC, transporter
HFP99_RS16045	ENOG4107QWP	ABC-2 type transporter
HFP99_RS16050	ENOG4107QWP	ABC-2 type transporter
HFP99_RS16055	ENOG4107QZF	nitrite reductase NADPH large subunit
HFP99_RS16060	ENOG4105WZK	nitrite reductase NADPH small subunit
HFP99_RS16065	ENOG4107V9H	nitrite transporter
HFP99_RS16070	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HFP99_RS16075	ENOG4105CJW	magnesium transporter
HFP99_RS16080	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HFP99_RS16085	ENOG4105EX9	Membrane
HFP99_RS16095	ENOG4105CNG	UPF0061 protein
HFP99_RS16100	ENOG4105N7H	Cytochrome
HFP99_RS16105	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HFP99_RS16110	ENOG4108VUY	thioesterase Superfamily protein
HFP99_RS16125	ENOG4108RPX	mosc domain containing protein
HFP99_RS16130	ENOG4105D38	putrescine abc transporter
HFP99_RS16135	ENOG4105F38	ABC transporter, permease
HFP99_RS16140	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HFP99_RS16145	ENOG4108HM4	ABC transporter
HFP99_RS16155	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HFP99_RS16160	ENOG4105CFQ	glutamine synthetase
HFP99_RS16165	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HFP99_RS16180	ENOG4108RH0	Crea protein
HFP99_RS16185	ENOG4105C5I	Dehydrogenase
HFP99_RS16190	ENOG4105R8A	Heat shock protein
HFP99_RS16205	ENOG4107R28	alpha amylase, catalytic region
HFP99_RS16215	ENOG4105EQQ	protein containing aminopeptidase domain
HFP99_RS16250	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
HFP99_RS16255	ENOG4107EXC	regulatoR
HFP99_RS16265	ENOG4105JJR	Histidine kinase
HFP99_RS16275	ENOG4105C6K	Malic enzyme
HFP99_RS16280	ENOG4105CGD	Nad-dependent epimerase dehydratase
HFP99_RS16285	ENOG4105VFB	Binds the 23S rRNA (By similarity)
HFP99_RS16290	ENOG4105C25	Primosomal protein n'
HFP99_RS16295	ENOG4105UYK	outer membrane protein a
HFP99_RS16300	ENOG4105C7B	Threonine dehydratase
HFP99_RS16305	ENOG4105C01	Dihydroxy-acid dehydratase
HFP99_RS16310	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HFP99_RS16315	ENOG4105P3Y	Acetolactate synthase 2 regulatory subunit
HFP99_RS16325	ENOG4105C0P	Mg chelatase subunit ChlI
HFP99_RS16330	ENOG4106HNH	Acyl-transferase
HFP99_RS16335	ENOG4106HNH	Acyl-transferase
HFP99_RS16340	ENOG4105EWC	Purine nucleoside phosphorylase
HFP99_RS16350	ENOG4108RWI	nicotinamidase
HFP99_RS16355	ENOG4107RH7	Nicotinate phosphoribosyltransferase
HFP99_RS16360	ENOG4105EHI	Phosphonate ABC transporter, periplasmic
HFP99_RS16365	ENOG4108VA1	ABC transporter
HFP99_RS16370	ENOG4105S7S	phosphonate abc transporter
HFP99_RS16375	ENOG4108Z33	Thiol disulfide Interchange Protein
HFP99_RS16380	ENOG4105E27	serine threonine protein kinase
HFP99_RS16390	ENOG4105PC1	Conserved Protein
HFP99_RS16410	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HFP99_RS16415	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HFP99_RS16420	ENOG4105DSJ	YicC domain protein
HFP99_RS16430	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HFP99_RS16435	ENOG4105XA0	heptosyltransferase ii
HFP99_RS16440	ENOG4106WTF	Glycosyl transferase, family 2
HFP99_RS16445	ENOG4105M5K	heptosyltransferase
HFP99_RS16450	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HFP99_RS16455	ENOG4108MJ5	VirK protein
HFP99_RS16460	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HFP99_RS16470	ENOG4105W0E	50S ribosomal protein L33
HFP99_RS16475	ENOG4105KDC	50s ribosomal protein l28
HFP99_RS16480	ENOG4105W5Q	DNA repair protein (RadC
HFP99_RS16485	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HFP99_RS16490	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HFP99_RS16495	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
HFP99_RS16510	ENOG4105D64	Mechanosensitive ion channel
HFP99_RS16515	ENOG4107QP8	phosphohexose isomerase
HFP99_RS16520	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HFP99_RS16525	ENOG4105EMY	transcriptional regulator
HFP99_RS16535	ENOG4105CD5	CoA-binding domain protein
HFP99_RS16565	ENOG4108Z0R	Transferase
HFP99_RS16570	ENOG4105C2M	dna polymerase I
HFP99_RS16575	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
HFP99_RS16580	ENOG41065UX	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity)
HFP99_RS16590	ENOG4105D7W	serine acetyltransferase
HFP99_RS16595	ENOG41076HS	cation diffusion facilitator family transporter
HFP99_RS16600	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HFP99_RS16605	ENOG4105E0F	Histidine kinase
HFP99_RS16610	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
HFP99_RS16615	ENOG4107R73	Mate efflux family protein
HFP99_RS16630	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HFP99_RS16635	ENOG4105E55	glycerol-3-phosphate acyltransferase
HFP99_RS16640	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HFP99_RS16645	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
HFP99_RS16650	ENOG4105X6C	Flagellar basal body-associated protein FliL
HFP99_RS16665	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
HFP99_RS16685	ENOG4105PF3	O-Antigen polymerase
HFP99_RS16695	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
HFP99_RS16700	ENOG4107Z3H	Transcriptional regulator, TetR family
HFP99_RS16705	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HFP99_RS16710	ENOG4105CPQ	Dehydrogenase
HFP99_RS16720	ENOG4105BZU	Histidine kinase
HFP99_RS16725	ENOG4105C4R	Atp-dependent dna helicase
HFP99_RS16730	ENOG4105C9B	Cysteine desulfurase
HFP99_RS16735	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HFP99_RS16740	ENOG4105CUZ	uba thif-type nad fad binding protein
HFP99_RS16775	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HFP99_RS16780	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HFP99_RS16785	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HFP99_RS16790	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HFP99_RS16795	ENOG4105FCD	Major Facilitator
HFP99_RS16800	ENOG4105DY9	regulatoR
HFP99_RS16805	ENOG4108HRK	Histidine kinase
HFP99_RS16815	ENOG4105EU0	Major facilitator Superfamily
HFP99_RS16820	ENOG4105CBX	hi0933 family
HFP99_RS16825	ENOG41090A1	ferritin
HFP99_RS16830	ENOG4105BZU	Histidine kinase
HFP99_RS16835	ENOG4105RKW	reductase (By
HFP99_RS16840	ENOG4108M6U	Universal stress protein A
HFP99_RS16870	ENOG4105EMK	carboxylate amino acid amine transporter
HFP99_RS16885	ENOG4105DKP	glycosyl transferase, family 9
HFP99_RS16900	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HFP99_RS16905	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HFP99_RS16910	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
HFP99_RS16920	ENOG4108EUD	Lysophospholipase
HFP99_RS16925	ENOG4105DQF	Hydrolase
HFP99_RS16960	ENOG4105Y7M	Transcriptional regulator, TetR family
HFP99_RS16965	ENOG410624X	efflux transporter, rnd family, mfp subunit
HFP99_RS16970	ENOG4105BZS	acriflavin resistance protein
HFP99_RS16980	ENOG4105DC8	reductase
HFP99_RS16985	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
HFP99_RS16990	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
HFP99_RS16995	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
HFP99_RS17000	ENOG4105C08	Histidine kinase
HFP99_RS17005	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
HFP99_RS17010	ENOG4105C2C	drug resistance transporter, Bcr CflA
HFP99_RS17025	ENOG4105JKW	Valine--pyruvate aminotransferase
HFP99_RS17030	ENOG4108ZNX	Heat shock protein
HFP99_RS17035	ENOG4108ZNX	Heat shock protein
HFP99_RS17040	ENOG4105IGJ	Zn-dependent Hydrolase of the beta-lactamase fold protein
HFP99_RS17045	ENOG4105ECQ	AraC Family Transcriptional Regulator
HFP99_RS17050	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HFP99_RS17055	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HFP99_RS17060	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HFP99_RS17065	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HFP99_RS17070	ENOG4105EAB	amino acid AbC transporter
HFP99_RS17075	ENOG4105E5Q	amino acid AbC transporter
HFP99_RS17080	ENOG4105CDA	abc transporter atp-binding protein
HFP99_RS17085	ENOG4105VG0	50S ribosomal protein l34
HFP99_RS17090	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HFP99_RS17095	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HFP99_RS17100	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HFP99_RS17105	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HFP99_RS17110	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
HFP99_RS17115	ENOG4105J76	Periplasmic binding protein
HFP99_RS17120	ENOG4105E0A	ABC, transporter
HFP99_RS17125	ENOG4105IBP	Cyclic peptide transporter
HFP99_RS17130	ENOG4105E0K	tonB-dependent siderophore receptor
HFP99_RS17135	ENOG4105QTB	Flavodoxin
HFP99_RS17140	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HFP99_RS17145	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HFP99_RS17150	ENOG4107QJE	Chromosome Partitioning Protein
HFP99_RS17155	ENOG4105FA0	parb-like partition protein
HFP99_RS17165	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HFP99_RS17170	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HFP99_RS17175	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HFP99_RS17180	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HFP99_RS17185	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HFP99_RS17190	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HFP99_RS17195	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HFP99_RS17200	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HFP99_RS17205	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HFP99_RS17210	ENOG4105CT7	inner membrane cred family protein
HFP99_RS17220	ENOG4105EB3	Histidine kinase
HFP99_RS17225	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HFP99_RS17230	ENOG410804X	Transcriptional regulator
HFP99_RS17240	ENOG4105VJY	transcriptional regulator
HFP99_RS17260	ENOG4109015	Biopolymer transport protein exbD tolR
HFP99_RS17265	ENOG410822N	TonB family
HFP99_RS17310	ENOG4105DZC	cytosine deaminase
HFP99_RS17315	ENOG4105WMR	Protein CrcB homolog
HFP99_RS17320	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HFP99_RS17325	ENOG4105JC1	sterol-binding domain protein
HFP99_RS17330	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
HFP99_RS17335	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HFP99_RS17340	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
HFP99_RS17345	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HFP99_RS17350	ENOG4105F8V	Hydrolase, tatD family
HFP99_RS17355	ENOG4105D52	delta-aminolevulinic acid dehydratase
HFP99_RS17360	ENOG4105DGW	oligopeptidase A
HFP99_RS17365	ENOG4105BZU	Histidine kinase
HFP99_RS17370	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
HFP99_RS17385	ENOG4105C9X	ppx gppa phosphatase
HFP99_RS17390	ENOG4105C1J	atp-dependent rna helicase
HFP99_RS17400	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HFP99_RS17410	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HFP99_RS17415	ENOG4107QK7	reductase
HFP99_RS17420	ENOG4105W0Z	cytoplasmic protein
HFP99_RS17435	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
HFP99_RS17450	ENOG4108IV0	ABC, transporter
HFP99_RS17455	ENOG4105C0Z	ABC transporter
HFP99_RS17460	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
HFP99_RS17465	ENOG4105C32	Amino acid ABC transporter (Permease)
HFP99_RS17470	ENOG4105CP9	extracellular ligand-binding receptor
HFP99_RS17475	ENOG4105ETE	Transcriptional regulator (LacI family
HFP99_RS17480	ENOG4108JUA	Transcriptional regulator
HFP99_RS17485	ENOG4105CNW	domain protein
HFP99_RS17490	ENOG4108EQM	faD-dependent pyridine nucleotide-disulfide oxidoreductase
HFP99_RS17500	ENOG4105HEE	Binding Domain protein
HFP99_RS17515	ENOG4105CIC	tryptophan-specific transport protein
HFP99_RS17520	ENOG4105CIC	tryptophan-specific transport protein
HFP99_RS17550	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
HFP99_RS17555	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
HFP99_RS17560	ENOG4108R3E	Dna-3-methyladenine glycosylase i
HFP99_RS17565	ENOG4105D3W	isochorismatase
HFP99_RS17585	ENOG4108ZG0	Ompa motb domain protein
HFP99_RS17590	ENOG4105M4H	endoribonuclease L-psp
HFP99_RS17595	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
HFP99_RS17615	ENOG4105E0F	Histidine kinase
HFP99_RS17625	ENOG4105CHU	acetyl-coa acetyltransferase
HFP99_RS17630	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HFP99_RS17635	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HFP99_RS17640	ENOG4105D9Y	Splits dipeptides with a prolyl residue in the C- terminal position (By similarity)
HFP99_RS17645	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HFP99_RS17650	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HFP99_RS17655	ENOG4108RR8	protoporphyrinogen oxidase
HFP99_RS17690	ENOG4105CQ4	Transcriptional regulator
HFP99_RS17695	ENOG4105CNT	hydrolase family 2
HFP99_RS17700	ENOG4105FK9	beta-D-galactosidase beta subunit
HFP99_RS17705	ENOG4105E5D	amino acid
HFP99_RS17710	ENOG4108Y51	tRNA-binding protein
HFP99_RS17715	ENOG4105E5D	amino acid
HFP99_RS17720	ENOG4105DHU	Bile acid
HFP99_RS17750	ENOG4105CR8	Transcriptional regulator
HFP99_RS17760	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
HFP99_RS17785	ENOG4105CC0	LysR family Transcriptional regulator
HFP99_RS17795	ENOG4105UIB	(ABC) transporter
HFP99_RS17800	ENOG4108JQ9	ABC transporter
HFP99_RS17805	ENOG4105DIH	basic membrane
HFP99_RS17820	ENOG4105C4R	Atp-dependent dna helicase
HFP99_RS17835	ENOG4108UK5	Transposase
HFP99_RS17840	ENOG4105HEI	LysR family (Transcriptional regulator
HFP99_RS17860	ENOG4105K3G	Periplasmic Protein
HFP99_RS17875	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HFP99_RS17885	ENOG41061EV	selenium-binding protein YdfZ
HFP99_RS17905	ENOG4108YH8	Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity)
HFP99_RS17910	ENOG4105EJC	lysr family transcriptional regulator
HFP99_RS17915	ENOG410829K	Lysine exporter protein (Lyse ygga)
HFP99_RS17920	ENOG4105CUC	YeeE YedE family protein
HFP99_RS17925	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
HFP99_RS17930	ENOG4105ECQ	AraC Family Transcriptional Regulator
HFP99_RS17935	ENOG4105FR1	rard protein
HFP99_RS17945	ENOG4105C26	Dehydrogenase
HFP99_RS17950	ENOG4108JCI	Transcriptional regulator
HFP99_RS17960	ENOG4105C26	Dehydrogenase
HFP99_RS17965	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HFP99_RS17970	ENOG4107R11	Transcriptional regulator
HFP99_RS17975	ENOG4108TFM	Kinase, PfkB family
HFP99_RS17995	ENOG4105CGY	Dna recombination protein
HFP99_RS18000	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HFP99_RS18005	ENOG4105C1A	potassium transporter peripheral membrane
HFP99_RS18010	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HFP99_RS18015	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HFP99_RS18020	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HFP99_RS18030	ENOG4105C79	DNA protecting protein DprA
HFP99_RS18035	ENOG4108RPN	Protein smg homolog
HFP99_RS18040	ENOG4108WI1	Dna topoisomerase
HFP99_RS18045	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HFP99_RS18050	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HFP99_RS18055	ENOG4105E2X	shikimate dehydrogenase
HFP99_RS18060	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HFP99_RS18065	ENOG4106RE7	Cytochrome
HFP99_RS18070	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
HFP99_RS18075	ENOG4105XCT	Protein of unknown function (DUF2489)
HFP99_RS18080	ENOG4105D4P	Coproporphyrinogen iii oxidase
HFP99_RS18085	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
HFP99_RS18090	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HFP99_RS18095	ENOG4105CUX	Signal transduction histidine kinase
HFP99_RS18105	ENOG4105C5F	glutamine synthetase
HFP99_RS18110	ENOG4105CI3	gtp-binding protein typa
HFP99_RS18115	ENOG4107S2Z	UPF0761 membrane protein
HFP99_RS18120	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HFP99_RS18130	ENOG4105SUU	thioesterase domain
HFP99_RS18140	ENOG4105CB5	ATP-dependent DNA helicase recG
HFP99_RS18145	ENOG4105JIM	Phosphatidylserine synthase
HFP99_RS18150	ENOG4105C6Z	Gluconate
HFP99_RS18155	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
HFP99_RS18160	ENOG4105C01	Dihydroxy-acid dehydratase
HFP99_RS18165	ENOG4108UHU	Aldolase
HFP99_RS18180	ENOG4105DIQ	Transcriptional regulator
HFP99_RS18190	ENOG41063SB	peptidase
HFP99_RS18195	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HFP99_RS18200	ENOG4107YZP	Rhodanese domain protein
HFP99_RS18205	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
HFP99_RS18210	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HFP99_RS18215	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
HFP99_RS18220	ENOG4105MJ2	Competence protein
HFP99_RS18225	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HFP99_RS18240	ENOG4105BZM	domain protein
HFP99_RS18245	ENOG4108RRZ	Transcription elongation factor GreB
HFP99_RS18255	ENOG4105E0F	Histidine kinase
HFP99_RS18265	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HFP99_RS18270	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HFP99_RS18275	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HFP99_RS18280	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HFP99_RS18285	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HFP99_RS18290	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HFP99_RS18295	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HFP99_RS18300	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HFP99_RS18305	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HFP99_RS18310	ENOG41083MP	50s ribosomal protein l29
HFP99_RS18315	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HFP99_RS18320	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HFP99_RS18325	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HFP99_RS18330	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HFP99_RS18335	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HFP99_RS18340	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HFP99_RS18345	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HFP99_RS18350	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HFP99_RS18355	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HFP99_RS18360	ENOG4105VPB	50S ribosomal protein L30
HFP99_RS18365	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HFP99_RS18370	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HFP99_RS18375	ENOG41067V7	50S ribosomal protein L36
HFP99_RS18380	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HFP99_RS18385	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HFP99_RS18390	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HFP99_RS18395	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HFP99_RS18400	ENOG4108ZT0	50S ribosomal protein l17
HFP99_RS18450	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
HFP99_RS18455	ENOG4108W5M	transcriptional regulator
HFP99_RS18460	ENOG4105EMU	Dehydrogenase
HFP99_RS18475	ENOG4105CUG	Oligopeptidase b
HFP99_RS18495	ENOG4107FS9	Membrane
HFP99_RS18510	ENOG4105JQN	Transcriptional regulator
HFP99_RS18525	ENOG4105VVZ	metal-binding protein
HFP99_RS18530	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
HFP99_RS18550	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
HFP99_RS18560	ENOG4107RZC	phospholipase d
HFP99_RS18570	ENOG4105EJ2	Transcriptional regulator
HFP99_RS18575	ENOG4108Y73	Membrane
HFP99_RS18585	ENOG4106H78	methyltransferase
HFP99_RS18590	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HFP99_RS18595	ENOG4105CAK	Cell division ATP-binding protein ftsE
HFP99_RS18600	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
HFP99_RS18605	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HFP99_RS18610	ENOG41077A9	carbonic anhydrase
HFP99_RS18615	ENOG4105CZE	histidine utilization repressor
HFP99_RS18620	ENOG4105CI2	imidazolone-5-propionate hydrolase
HFP99_RS18625	ENOG41088SP	formiminoglutamate hydrolase
HFP99_RS18630	ENOG4105CGP	Urocanate hydratase
HFP99_RS18635	ENOG4105C84	Histidine ammonia-lyase
HFP99_RS18640	ENOG4105EWV	Sodium calcium exchanger membrane region
HFP99_RS18645	ENOG4107XTP	(EAL) domain protein
HFP99_RS18700	ENOG4105D7Q	type ii secretion system
HFP99_RS18715	ENOG4108VAU	general secretion pathway protein G
HFP99_RS18750	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
HFP99_RS18755	ENOG4105VQ7	Rod shape-determining protein MreD
HFP99_RS18760	ENOG4108Z03	MAF-like protein
HFP99_RS18765	ENOG4105C03	ribonuclease
HFP99_RS18770	ENOG4105QD6	exported protein
HFP99_RS18780	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HFP99_RS18795	ENOG4105CSH	Transporter
HFP99_RS18805	ENOG4105CGZ	zinc metallopeptidase
HFP99_RS18825	ENOG4106H3A	restriction
HFP99_RS18830	ENOG4105CVR	type I restriction-modification system
HFP99_RS18835	ENOG4105EKX	Restriction modification system DNA (Specificity
HFP99_RS18850	ENOG4105DZR	Type I site-specific deoxyribonuclease
HFP99_RS18855	ENOG41090ED	Protein with unknown function (DUF469)
HFP99_RS18885	ENOG4105DFP	Integrase
HFP99_RS18895	ENOG4105EEQ	Na H antiporter
HFP99_RS18900	ENOG4105C3R	Methionine synthase
HFP99_RS18910	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HFP99_RS18935	ENOG4108MR7	Arylsulfotransferase
HFP99_RS18940	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
HFP99_RS18945	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HFP99_RS18950	ENOG4105D06	uba thif-type nad fad binding protein
HFP99_RS18960	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HFP99_RS18965	ENOG4105D41	biosynthesis protein thiH
HFP99_RS18970	ENOG4108UK5	Transposase
HFP99_RS18980	ENOG4108WEF	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity)
HFP99_RS18990	ENOG4105BZU	Histidine kinase
HFP99_RS18995	ENOG4108TPP	exopolysaccharide synthesis
HFP99_RS19010	ENOG4105N0V	mono-oxygenase ydhR
HFP99_RS19015	ENOG4105KVH	Transcriptional regulator
HFP99_RS19030	ENOG4105E0K	tonB-dependent siderophore receptor
HFP99_RS19035	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
HFP99_RS19040	ENOG4105FCK	Membrane
HFP99_RS19045	ENOG4105CBT	Fructose-1,6-bisphosphatase
HFP99_RS19050	ENOG4105KRS	Proteinase inhibitor
HFP99_RS19055	ENOG410601J	HemY protein
HFP99_RS19060	ENOG4105ECF	c-methyltransferase
HFP99_RS19065	ENOG41076E6	Uroporphyrinogen-III Synthase
HFP99_RS19070	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HFP99_RS19075	ENOG4107T0K	Adenylate cyclase
HFP99_RS19080	ENOG4106CJB	Phospholipase Carboxylesterase
HFP99_RS19085	ENOG4105XQ6	frataxin-like protein
HFP99_RS19095	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HFP99_RS19100	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HFP99_RS19110	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HFP99_RS19115	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
HFP99_RS19135	ENOG4108Z86	Glutamine amidotransferase
HFP99_RS19140	ENOG410667J	hydrolase
HFP99_RS19150	ENOG4107K5X	Membrane-bound metal-dependent hydrolase
HFP99_RS19155	ENOG4108I62	cina-like protein
HFP99_RS19165	ENOG4105CVG	Homoserine O-transsuccinylase
HFP99_RS19175	ENOG4108YXU	transcriptional regulator AsnC family
HFP99_RS19180	ENOG4105E0M	Sulfatase
HFP99_RS19195	ENOG4105KT7	mgtC SapB transporter
HFP99_RS19215	ENOG4105EMU	Dehydrogenase
HFP99_RS19230	ENOG4108I6A	alcohol dehydrogenase
HFP99_RS19270	ENOG4107IFA	Lipase (EC 3.1.1.3)
HFP99_RS19280	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HFP99_RS19285	ENOG4108UB4	uncharacterized protein ygjQ
HFP99_RS19290	ENOG4105CEY	Amp-dependent synthetase and ligase
HFP99_RS19295	ENOG4105DNI	Converts SHCHC to OSB (By similarity)
HFP99_RS19300	ENOG4108IPT	Naphthoate synthase
HFP99_RS19305	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
HFP99_RS19310	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
HFP99_RS19315	ENOG4105E4F	Isochorismate synthase
HFP99_RS19320	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
HFP99_RS19325	ENOG4105D22	carbon starvation protein
HFP99_RS19330	ENOG4105VCD	cytoplasmic protein
HFP99_RS19335	ENOG4105CKI	cobalamin synthesis protein
HFP99_RS19360	ENOG4105C1J	atp-dependent rna helicase
HFP99_RS19365	ENOG4105D9N	nucleoside
HFP99_RS19370	ENOG4107VGF	ig domain protein group 2 domain protein
HFP99_RS19375	ENOG4108UPT	UPF0178 protein
HFP99_RS19400	ENOG4105E61	Mannitol repressor protein
HFP99_RS19405	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
HFP99_RS19410	ENOG4105CTS	PTS system mannitol-specific
HFP99_RS19415	ENOG4108IEC	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
HFP99_RS19420	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
HFP99_RS19425	ENOG4105NNS	Autoinducer synthesis protein
HFP99_RS19430	ENOG4105VJY	transcriptional regulator
HFP99_RS19435	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
HFP99_RS19440	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
HFP99_RS19445	ENOG4105D1S	lipid A biosynthesis
HFP99_RS19450	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HFP99_RS19455	ENOG4105DFG	type I secretion outer membrane protein
HFP99_RS19460	ENOG41087AY	ADP-Ribose pyrophosphatase
HFP99_RS19465	ENOG4108SX3	cytoplasmic protein
HFP99_RS19475	ENOG4105IPS	esterase
HFP99_RS19490	ENOG4105Y49	secretion protein, HlyD family
HFP99_RS19495	ENOG4105DSW	Fusaric acid resistance protein
HFP99_RS19500	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HFP99_RS19505	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HFP99_RS19525	ENOG4105KD7	acetyltransferase
HFP99_RS19560	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HFP99_RS19570	ENOG4105N2G	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HFP99_RS19590	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
HFP99_RS19595	ENOG41087YS	Phage shock protein A
HFP99_RS19610	ENOG41082IR	Excinuclease ABC C subunit domain protein
HFP99_RS19615	ENOG4105FR1	rard protein
HFP99_RS19620	ENOG4108RG0	uracil-dna glycosylase
HFP99_RS19630	ENOG4105ETT	transcriptional Regulator, LysR family
HFP99_RS19635	ENOG4105FAV	ABC, transporter
HFP99_RS19640	ENOG4105FDK	ABC transporter
HFP99_RS19645	ENOG4105NXV	High-affinity zinc uptake system protein
HFP99_RS19665	ENOG4105DR5	peptidase
HFP99_RS19710	ENOG4107TH8	cina domain protein
HFP99_RS19715	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HFP99_RS19720	ENOG4105Y3E	Modulates RecA activity (By similarity)
HFP99_RS19725	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HFP99_RS19730	ENOG4105CFH	Aspartokinase
HFP99_RS19735	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
HFP99_RS19770	ENOG41061WM	D-Alanyl-D-Alanine
HFP99_RS19775	ENOG4106W5V	Membrane
HFP99_RS19795	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HFP99_RS19800	ENOG4108M8S	permease YjgP YjgQ family protein
HFP99_RS19805	ENOG4108K5H	permease YjgP YjgQ family protein
HFP99_RS19825	ENOG4105BZU	Histidine kinase
HFP99_RS19830	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HFP99_RS19845	ENOG4105EYA	deoxyribonuclease
HFP99_RS19850	ENOG4105D9N	nucleoside
HFP99_RS19860	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
HFP99_RS19865	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
HFP99_RS19870	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
HFP99_RS19875	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HFP99_RS19885	ENOG4108NST	exported protein
HFP99_RS19895	ENOG4105EAC	phosphoserine phosphatase
HFP99_RS19910	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HFP99_RS19920	ENOG4108ZVW	Anti-RNA polymerase sigma 70 factor
HFP99_RS19925	ENOG4105K70	DNA-binding protein
HFP99_RS19940	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HFP99_RS19945	ENOG4105MYN	Zinc uptake regulation protein
HFP99_RS19960	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
HFP99_RS19965	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
HFP99_RS19970	ENOG4105C1J	atp-dependent rna helicase
HFP99_RS19975	ENOG4105D1Q	UPF0246 protein
HFP99_RS19980	ENOG4105CZX	twitching motility protein
HFP99_RS19985	ENOG4105CZX	twitching motility protein
HFP99_RS19990	ENOG4105DFA	alanine racemase domain protein
HFP99_RS19995	ENOG4105II7	pyrroline-5-carboxylate reductase
HFP99_RS20000	ENOG4108VIA	integral membrane protein
HFP99_RS20005	ENOG4105VZ9	UPF0235 protein
HFP99_RS20025	ENOG4105XTV	UPF0231 protein
HFP99_RS20035	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
HFP99_RS20040	ENOG4107QQ0	gntp family
HFP99_RS20045	ENOG4105BZW	Glycerate kinase
HFP99_RS20060	ENOG4105HEI	LysR family (Transcriptional regulator
HFP99_RS20065	ENOG4105D9N	nucleoside
HFP99_RS20080	ENOG4108YZN	class I peptide chain release factor
HFP99_RS20085	ENOG4108YZA	Nitrogen regulatory protein pii
HFP99_RS20095	ENOG4107QKW	extracellular solute-binding protein family 1
HFP99_RS20110	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HFP99_RS20115	ENOG4105EZR	dyp-type peroxidase family protein
HFP99_RS20120	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
HFP99_RS20125	ENOG4105E5Z	arginine transporter ATP-binding subunit
HFP99_RS20130	ENOG4106PMH	Extracellular solute-binding protein family 3
HFP99_RS20135	ENOG4105GBT	ABC transporter
HFP99_RS20140	ENOG4105DMR	ABC, transporter
HFP99_RS20145	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HFP99_RS20150	ENOG4108UV7	flagellar protein motX
HFP99_RS20155	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HFP99_RS20165	ENOG4108JU6	CBS domain protein
HFP99_RS20170	ENOG4106KVJ	cytochrome C assembly protein
HFP99_RS20175	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HFP99_RS20180	ENOG4105K5M	30s ribosomal protein S16
HFP99_RS20185	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HFP99_RS20190	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HFP99_RS20195	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HFP99_RS20210	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HFP99_RS20220	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HFP99_RS20225	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HFP99_RS20230	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HFP99_RS20240	ENOG41063Z6	transcriptional regulator, lysR family
HFP99_RS20245	ENOG41080HT	Transcriptional regulator, arsr family
HFP99_RS20250	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HFP99_RS20255	ENOG4105CJR	Integral membrane protein (MviN
HFP99_RS20260	ENOG4105DTN	riboflavin biosynthesis protein ribF
HFP99_RS20265	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HFP99_RS20270	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HFP99_RS20275	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
HFP99_RS20280	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HFP99_RS20310	ENOG4105X0D	Fimbrial protein
HFP99_RS20340	ENOG4105C4K	Nad synthetase
HFP99_RS20345	ENOG4108YZA	Nitrogen regulatory protein pii
HFP99_RS20355	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
HFP99_RS20360	ENOG4106TD9	Diguanylate cyclase
HFP99_RS20365	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HFP99_RS20370	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HFP99_RS20380	ENOG4107YB6	acetyltransferase, (GNAT) family
HFP99_RS20395	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
HFP99_RS20400	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HFP99_RS20405	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HFP99_RS20410	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HFP99_RS20415	ENOG4105DP0	ferredoxin-NADP reductase
HFP99_RS20450	ENOG4105W39	Membrane
HFP99_RS20460	ENOG4105D9M	gamma-glutamylcysteine synthetase
HFP99_RS20465	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
HFP99_RS20470	ENOG4108IJ0	Aspartate ammonia-lyase
HFP99_RS20475	ENOG4108YH1	overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7
HFP99_RS20485	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HFP99_RS20490	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HFP99_RS20500	ENOG4105BZU	Histidine kinase
HFP99_RS20515	ENOG4105D3G	Pseudouridine synthase
HFP99_RS20520	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
HFP99_RS20550	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
HFP99_RS20560	ENOG4108I5D	sulfate abc transporter
HFP99_RS20565	ENOG4105ECW	sulfate abc transporter
HFP99_RS20570	ENOG4108IJ6	ABC transporter
HFP99_RS20575	ENOG4107R11	Transcriptional regulator
HFP99_RS20580	ENOG4108M1A	Chitin-binding protein
HFP99_RS20585	ENOG4108N3W	hemolysin secretion protein
HFP99_RS20610	ENOG4105G0K	glycine radical enzyme YjjI family
HFP99_RS20615	ENOG41076CZ	activating enzyme
HFP99_RS20630	ENOG4105CGF	Aromatic amino acid aminotransferase
HFP99_RS20660	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
HFP99_RS20665	ENOG4105C1J	atp-dependent rna helicase
HFP99_RS20675	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
HFP99_RS20685	ENOG4107QSI	ABC, transporter
HFP99_RS20695	ENOG4105EQK	-acetyltransferase
HFP99_RS20700	ENOG4106WH9	Protein of unknown function (DUF2753)
HFP99_RS20705	ENOG4105E39	Enoyl-CoA hydratase
HFP99_RS20720	ENOG4108RZ4	Short-chain dehydrogenase reductase Sdr
HFP99_RS20725	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HFP99_RS20730	ENOG4105DVT	helicase
HFP99_RS20735	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HFP99_RS20740	ENOG4105C8Q	Methyl-accepting chemotaxis
HFP99_RS20745	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HFP99_RS20750	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HFP99_RS20755	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HFP99_RS20760	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HFP99_RS20770	ENOG4105KJB	cyd operon protein YbgE
HFP99_RS20775	ENOG4107YD3	Thioesterase
HFP99_RS20780	ENOG4105E02	MotA TolQ exbB proton channel
HFP99_RS20785	ENOG4105M8F	Biopolymer transport protein exbD tolR
HFP99_RS20795	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HFP99_RS20800	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HFP99_RS20805	ENOG4105UFD	tol-pal system protein YbgF
HFP99_RS20870	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HFP99_RS20875	ENOG4105DSB	aldose 1-epimerase
HFP99_RS20880	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HFP99_RS20885	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
HFP99_RS20890	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HFP99_RS20900	ENOG4105E0X	reductase
HFP99_RS20915	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
HFP99_RS20920	ENOG4105K56	Transcriptional regulator
HFP99_RS20935	ENOG4105EW9	transcriptional regulator AsnC family
HFP99_RS20950	ENOG410667J	hydrolase
HFP99_RS20970	ENOG4105C8J	)-transporter
HFP99_RS20985	ENOG4107SQD	Transcriptional regulator, GntR family
HFP99_RS21010	ENOG4108IQE	Amp-dependent synthetase and ligase
HFP99_RS21020	ENOG41080E2	ribosomal-protein-alanine acetyltransferase
HFP99_RS21035	ENOG4105EV2	VWA domain protein interacting with AAA ATPase
HFP99_RS21040	ENOG4105BZU	Histidine kinase
HFP99_RS21050	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
HFP99_RS21055	ENOG4105C09	Bile acid
HFP99_RS21060	ENOG4108MJ3	acetyltransferase
HFP99_RS21065	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HFP99_RS21085	ENOG4105DWY	Agmatine deiminase
HFP99_RS21090	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HFP99_RS21115	ENOG4105C1J	atp-dependent rna helicase
HFP99_RS21125	ENOG4107Y60	(LipO)protein
HFP99_RS21135	ENOG4106B0W	Curli production assembly transport component CsgG