locus-tag	class	description
U876_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
U876_RS00010	COG0592	DNA-directed DNA polymerase activity
U876_RS00030	COG2378	regulation of single-species biofilm formation
U876_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
U876_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
U876_RS00045	COG3977	Valine--pyruvate aminotransferase
U876_RS00060	COG2814	Major facilitator Superfamily
U876_RS00065	COG0745	RESPONSE REGULATOR receiver
U876_RS00070	COG2205	protein histidine kinase activity
U876_RS00090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
U876_RS00095	COG4191	Histidine kinase
U876_RS00095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U876_RS00100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U876_RS00105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U876_RS00110	COG1309	transcriptional regulator
U876_RS00140	COG0469	pyruvate kinase activity
U876_RS00145	COG2271	Major facilitator Superfamily
U876_RS00170	COG0561	phosphatase activity
U876_RS00175	COG2267	carboxylic ester hydrolase activity
U876_RS00185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
U876_RS00190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
U876_RS00195	COG1758	RNA polymerase activity
U876_RS00205	COG0859	PFAM glycosyl transferase family 9
U876_RS00210	COG3642	lipopolysaccharide core region biosynthetic process
U876_RS00245	COG0589	response to stress
U876_RS00250	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
U876_RS00260	COG1528	Iron-storage protein
U876_RS00265	COG2081	HI0933 family
U876_RS00270	COG2223	nitrite transmembrane transporter activity
U876_RS00290	COG3188	usher protein
U876_RS00310	COG2205	protein histidine kinase activity
U876_RS00310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U876_RS00320	COG3275	phosphorelay sensor kinase activity
U876_RS00325	COG3279	Response regulator of the LytR AlgR family
U876_RS00330	COG2223	nitrite transmembrane transporter activity
U876_RS00335	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
U876_RS00340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
U876_RS00355	COG0583	DNA-binding transcription factor activity
U876_RS00360	COG4206	TonB-dependent receptor
U876_RS00365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
U876_RS00400	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
U876_RS00405	COG2166	iron-sulfur cluster assembly
U876_RS00410	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
U876_RS00415	COG0210	DNA helicase
U876_RS00425	COG3245	cytochrome
U876_RS00430	COG1063	alcohol dehydrogenase
U876_RS00435	COG0156	8-amino-7-oxononanoate synthase activity
U876_RS00445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
U876_RS00460	COG3306	glycosyltransferase involved in LPS biosynthesis
U876_RS00480	COG1561	YicC-like family, N-terminal region
U876_RS00485	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
U876_RS00490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
U876_RS00500	COG0789	Transcriptional regulator
U876_RS00505	COG5001	Diguanylate cyclase
U876_RS00505	COG3706	GGDEF domain
U876_RS00505	COG2203	Gaf domain
U876_RS00505	COG4251	negative regulation of phosphorylation
U876_RS00510	COG3084	Protein conserved in bacteria
U876_RS00520	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
U876_RS00525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
U876_RS00530	COG3639	organic phosphonate transmembrane transporter activity
U876_RS00535	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
U876_RS00540	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
U876_RS00550	COG1335	isochorismatase
U876_RS00560	COG1683	Conserved Protein
U876_RS00565	COG0204	Acyl-transferase
U876_RS00570	COG0204	Acyl-transferase
U876_RS00575	COG0606	chelatase, subunit chli
U876_RS00585	COG3978	acetolactate synthase activity
U876_RS00595	COG0129	dihydroxy-acid dehydratase activity
U876_RS00615	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
U876_RS00620	COG0254	rRNA binding
U876_RS00625	COG0702	epimerase
U876_RS00630	COG0281	malic enzyme
U876_RS00640	COG2205	protein histidine kinase activity
U876_RS00645	COG0745	RESPONSE REGULATOR receiver
U876_RS00650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
U876_RS00665	COG0366	Alpha amylase catalytic
U876_RS00680	COG0443	Heat shock 70 kDa protein
U876_RS00685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
U876_RS00690	COG3045	CreA protein
U876_RS00710	COG0174	glutamine synthetase
U876_RS00730	COG3842	ATPase activity
U876_RS00735	COG1176	ABC-type spermidine putrescine transport system, permease component I
U876_RS00740	COG1177	transmembrane transport
U876_RS00745	COG2258	MOSC domain
U876_RS00760	COG2050	protein possibly involved in aromatic compounds catabolism
U876_RS00765	COG0514	ATP-dependent DNA helicase (RecQ)
U876_RS00775	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
U876_RS00785	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
U876_RS00790	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
U876_RS00800	COG2239	Acts as a magnesium transporter
U876_RS00805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
U876_RS00805	COG1648	precorrin-2 dehydrogenase activity
U876_RS00810	COG2116	formate transmembrane transporter activity
U876_RS00820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
U876_RS00835	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
U876_RS00840	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
U876_RS00860	COG1595	DNA-templated transcription, initiation
U876_RS00865	COG3806	Anti-sigma factor
U876_RS00870	COG1968	undecaprenyl-diphosphatase activity
U876_RS00875	COG0667	Aldo Keto reductase
U876_RS00880	COG2017	converts alpha-aldose to the beta-anomer
U876_RS00885	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
U876_RS00895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
U876_RS00900	COG1609	Transcriptional regulator
U876_RS00905	COG3250	beta-galactosidase activity
U876_RS00925	COG0840	transmembrane signaling receptor activity
U876_RS00950	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
U876_RS00955	COG1288	antiporter activity
U876_RS00960	COG1438	arginine binding
U876_RS00965	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
U876_RS00970	COG0540	Belongs to the ATCase OTCase family
U876_RS00985	COG0688	phosphatidylethanolamine metabolic process
U876_RS00995	COG3040	lipid binding
U876_RS01005	COG1979	alcohol dehydrogenase
U876_RS01010	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
U876_RS01015	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
U876_RS01025	COG2964	Protein conserved in bacteria
U876_RS01030	COG3681	Belongs to the UPF0597 family
U876_RS01040	COG0446	pyridine nucleotide-disulphide oxidoreductase
U876_RS01045	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U876_RS01050	COG0564	pseudouridine synthase activity
U876_RS01060	COG0542	response to heat
U876_RS01065	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
U876_RS01070	COG2502	aspartate--ammonia ligase
U876_RS01075	COG1522	sequence-specific DNA binding
U876_RS01085	COG5413	integral membrane protein
U876_RS01105	COG2205	protein histidine kinase activity
U876_RS01115	COG2204	response regulator
U876_RS01130	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
U876_RS01160	COG0243	molybdopterin cofactor binding
U876_RS01165	COG3005	denitrification pathway
U876_RS01170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
U876_RS01190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
U876_RS01195	COG0569	domain protein
U876_RS01200	COG0812	UDP-N-acetylmuramate dehydrogenase activity
U876_RS01225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
U876_RS01240	COG0250	Participates in transcription elongation, termination and antitermination
U876_RS01245	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
U876_RS01250	COG0081	regulation of translation
U876_RS01255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
U876_RS01260	COG0222	ribosome binding
U876_RS01265	COG0085	RNA polymerase activity
U876_RS01270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
U876_RS01280	COG2964	Protein conserved in bacteria
U876_RS01285	COG0251	oxidation-reduction process
U876_RS01295	COG2923	Belongs to the DsrF TusC family
U876_RS01300	COG2168	tRNA wobble position uridine thiolation
U876_RS01310	COG0049	tRNA binding
U876_RS01315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
U876_RS01320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
U876_RS01325	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
U876_RS01355	COG2252	PERMEase
U876_RS01360	COG2376	Dihydroxyacetone kinase
U876_RS01365	COG1461	Dihydroxyacetone kinase
U876_RS01380	COG3284	Transcriptional regulator
U876_RS01390	COG2957	Belongs to the agmatine deiminase family
U876_RS01395	COG4221	oxidoreductase activity
U876_RS01400	COG0628	permease
U876_RS01405	COG0494	nUDIX hydrolase
U876_RS01430	COG0753	catalase activity
U876_RS01435	COG1247	-acetyltransferase
U876_RS01455	COG2203	Gaf domain
U876_RS01455	COG2199	diguanylate cyclase activity
U876_RS01465	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
U876_RS01475	COG1175	transmembrane transport
U876_RS01500	COG0583	DNA-binding transcription factor activity
U876_RS01510	COG1741	Belongs to the pirin family
U876_RS01515	COG2259	Doxx family
U876_RS01520	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
U876_RS01525	COG1074	ATP-dependent DNA helicase activity
U876_RS01530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
U876_RS01540	COG0346	lactoylglutathione lyase activity
U876_RS01585	COG4251	negative regulation of phosphorylation
U876_RS01585	COG2203	Gaf domain
U876_RS01585	COG3706	GGDEF domain
U876_RS01585	COG5001	Diguanylate cyclase
U876_RS01590	COG4771	TonB-dependent receptor
U876_RS01595	COG1278	Cold shock
U876_RS01615	COG0629	single-stranded DNA binding
U876_RS01620	COG2197	response regulator
U876_RS01625	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
U876_RS01635	COG3047	cAMP biosynthetic process
U876_RS01640	COG0840	transmembrane signaling receptor activity
U876_RS01665	COG3135	benzoate transporter
U876_RS01670	COG1396	sequence-specific DNA binding
U876_RS01700	COG2926	Belongs to the UPF0265 family
U876_RS01710	COG3028	Belongs to the UPF0307 family
U876_RS01715	COG0312	modulator of DNA gyrase
U876_RS01720	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
U876_RS01725	COG5007	Belongs to the BolA IbaG family
U876_RS01735	COG2854	intermembrane phospholipid transfer
U876_RS01740	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
U876_RS01745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
U876_RS01750	COG1127	ABC transporter
U876_RS01755	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
U876_RS01755	COG0517	IMP dehydrogenase activity
U876_RS01760	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
U876_RS01765	COG3117	lipopolysaccharide transmembrane transporter activity
U876_RS01770	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
U876_RS01775	COG1137	ATPase activity
U876_RS01780	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
U876_RS01790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U876_RS01795	COG1660	Displays ATPase and GTPase activities
U876_RS01800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
U876_RS01805	COG3711	transcriptional antiterminator
U876_RS01805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U876_RS01820	COG3964	amidohydrolase
U876_RS01850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
U876_RS01855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
U876_RS01865	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
U876_RS01870	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
U876_RS01875	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
U876_RS01880	COG0723	plastoquinol--plastocyanin reductase activity
U876_RS01885	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
U876_RS01890	COG2857	Cytochrome c1
U876_RS01895	COG0625	glutathione transferase activity
U876_RS01900	COG2969	positive regulation of protein catabolic process
U876_RS01905	COG2823	Periplasmic or secreted lipoprotein
U876_RS01910	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
U876_RS01915	COG0792	nuclease activity
U876_RS01920	COG3107	peptidoglycan biosynthetic process
U876_RS01925	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
U876_RS01930	COG2001	Belongs to the MraZ family
U876_RS01935	COG0275	rRNA processing
U876_RS01940	COG3116	cell division
U876_RS01945	COG0768	penicillin binding
U876_RS01955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
U876_RS01960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
U876_RS01965	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
U876_RS01970	COG0772	Belongs to the SEDS family
U876_RS01975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
U876_RS01980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
U876_RS01985	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
U876_RS01990	COG0849	cell division
U876_RS01995	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
U876_RS02000	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
U876_RS02010	COG0653	protein targeting
U876_RS02020	COG0494	nUDIX hydrolase
U876_RS02025	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
U876_RS02030	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
U876_RS02045	COG1459	type II secretion system
U876_RS02050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
U876_RS02080	COG2186	Transcriptional regulator
U876_RS02085	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
U876_RS02090	COG0508	dehydrogenase complex catalyzes the overall conversion of
U876_RS02095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
U876_RS02100	COG5002	protein histidine kinase activity
U876_RS02100	COG3447	MASE1 domain protein
U876_RS02100	COG5001	Diguanylate cyclase
U876_RS02110	COG0840	transmembrane signaling receptor activity
U876_RS02115	COG0840	transmembrane signaling receptor activity
U876_RS02120	COG1752	Esterase of the alpha-beta hydrolase superfamily
U876_RS02125	COG1049	propionate catabolic process, 2-methylcitrate cycle
U876_RS02140	COG1280	lysine exporter protein (LysE YggA)
U876_RS02150	COG0523	cobalamin synthesis protein
U876_RS02155	COG0477	Major facilitator Superfamily
U876_RS02170	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
U876_RS02175	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
U876_RS02215	COG3314	Sporulation integral membrane protein YlbJ
U876_RS02220	COG0784	Response regulator, receiver
U876_RS02220	COG0835	chemotaxis
U876_RS02225	COG1028	Short-chain dehydrogenase reductase Sdr
U876_RS02230	COG1444	tRNA N-acetyltransferase activity
U876_RS02255	COG1803	Methylglyoxal synthase
U876_RS02270	COG0252	asparaginase activity
U876_RS02290	COG1263	PTS System
U876_RS02290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U876_RS02295	COG0366	Alpha amylase catalytic
U876_RS02300	COG0110	maltose O-acetyltransferase activity
U876_RS02305	COG1522	sequence-specific DNA binding
U876_RS02310	COG5006	permease, DMT superfamily
U876_RS02320	COG1012	belongs to the aldehyde dehydrogenase family
U876_RS02325	COG1177	transmembrane transport
U876_RS02330	COG1176	ABC-type spermidine putrescine transport system, permease component I
U876_RS02335	COG3842	ATPase activity
U876_RS02340	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
U876_RS02345	COG0583	DNA-binding transcription factor activity
U876_RS02350	COG1757	Na H antiporter
U876_RS02390	COG0297	glycogen (starch) synthase activity
U876_RS02395	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
U876_RS02400	COG2813	Specifically methylates the guanine in position
U876_RS02405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
U876_RS02410	COG5001	Diguanylate cyclase
U876_RS02410	COG4251	negative regulation of phosphorylation
U876_RS02410	COG3706	GGDEF domain
U876_RS02410	COG2203	Gaf domain
U876_RS02420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U876_RS02430	COG2995	paraquat-inducible protein a
U876_RS02435	COG3008	intermembrane lipid transfer
U876_RS02435	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
U876_RS02440	COG3009	Protein conserved in bacteria
U876_RS02455	COG3240	lipase activity
U876_RS02460	COG3111	PFAM Bacterial OB fold (BOF) protein
U876_RS02470	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
U876_RS02475	COG1194	a g-specific adenine glycosylase
U876_RS02485	COG3409	Peptidoglycan-binding domain 1 protein
U876_RS02485	COG3267	Type II secretory pathway component ExeA
U876_RS02495	COG0617	tRNA 3'-terminal CCA addition
U876_RS02510	COG1346	cytolysis
U876_RS02515	COG1380	Effector of murein hydrolase LrgA
U876_RS02520	COG0583	DNA-binding transcription factor activity
U876_RS02545	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
U876_RS02550	COG0306	phosphate transporter
U876_RS02555	COG1392	Phosphate transport regulator
U876_RS02570	COG1560	Kdo2-lipid A biosynthetic process
U876_RS02575	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
U876_RS02575	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
U876_RS02580	COG1538	Outer membrane efflux protein
U876_RS02585	COG0494	nUDIX hydrolase
U876_RS02590	COG3151	Protein conserved in bacteria
U876_RS02600	COG3150	esterase
U876_RS02605	COG1051	belongs to the nudix hydrolase family
U876_RS02620	COG1566	PFAM secretion protein HlyD family protein
U876_RS02625	COG1289	transmembrane transporter activity
U876_RS02675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U876_RS02700	COG0204	Acyl-transferase
U876_RS02705	COG1842	Phage shock protein A
U876_RS02720	COG2827	Endonuclease containing a URI domain
U876_RS02730	COG2962	Rard protein
U876_RS02735	COG1573	uracil-dna glycosylase
U876_RS02740	COG0697	spore germination
U876_RS02750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
U876_RS02755	COG1121	(ABC) transporter
U876_RS02760	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
U876_RS02780	COG0739	heme binding
U876_RS02790	COG3068	Protein conserved in bacteria
U876_RS02810	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
U876_RS02835	COG1546	Belongs to the CinA family
U876_RS02840	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
U876_RS02850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
U876_RS02855	COG0527	aspartate kinase activity
U876_RS02860	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
U876_RS02895	COG1686	Belongs to the peptidase S11 family
U876_RS02900	COG0586	Pfam SNARE associated Golgi protein
U876_RS02905	COG1253	flavin adenine dinucleotide binding
U876_RS02910	COG0525	valine-tRNA ligase activity
U876_RS02915	COG2927	DNA polymerase III (CHI subunit)
U876_RS02920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
U876_RS02925	COG0795	lipopolysaccharide-transporting ATPase activity
U876_RS02930	COG0795	lipopolysaccharide-transporting ATPase activity
U876_RS02945	COG0582	viral genome integration into host DNA
U876_RS02960	COG3561	AntA/AntB antirepressor
U876_RS02985	COG0004	ammonium transporteR
U876_RS02990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
U876_RS02995	COG2165	general secretion pathway protein
U876_RS03000	COG0084	hydrolase, TatD family'
U876_RS03005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
U876_RS03015	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
U876_RS03020	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
U876_RS03025	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
U876_RS03030	COG0813	purine-nucleoside phosphorylase activity
U876_RS03035	COG3447	MASE1 domain protein
U876_RS03035	COG5002	protein histidine kinase activity
U876_RS03035	COG5001	Diguanylate cyclase
U876_RS03045	COG0560	Phosphoserine phosphatase
U876_RS03070	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
U876_RS03075	COG0776	regulation of translation
U876_RS03085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
U876_RS03115	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
U876_RS03120	COG0513	Belongs to the DEAD box helicase family
U876_RS03125	COG3022	response to hydroperoxide
U876_RS03140	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
U876_RS03145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
U876_RS03150	COG0762	integral membrane protein
U876_RS03155	COG1872	DUF167
U876_RS03170	COG4166	transmembrane transport
U876_RS03180	COG0110	maltose O-acetyltransferase activity
U876_RS03190	COG1024	Enoyl-CoA hydratase
U876_RS03205	COG4221	oxidoreductase activity
U876_RS03210	COG0442	prolyl-tRNA aminoacylation
U876_RS03215	COG0840	transmembrane signaling receptor activity
U876_RS03220	COG0632	four-way junction helicase activity
U876_RS03225	COG2255	four-way junction helicase activity
U876_RS03230	COG1271	oxidase subunit
U876_RS03235	COG1294	oxidase, subunit
U876_RS03245	COG3790	cyd operon protein YbgE
U876_RS03250	COG0824	Thioesterase
U876_RS03255	COG0811	peptide transport
U876_RS03270	COG0823	Involved in the tonB-independent uptake of proteins
U876_RS03275	COG2885	chlorophyll binding
U876_RS03280	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
U876_RS03295	COG0840	transmembrane signaling receptor activity
U876_RS03300	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
U876_RS03305	COG0676	glucose-6-phosphate 1-epimerase activity
U876_RS03310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
U876_RS03315	COG1640	4-alpha-glucanotransferase
U876_RS03320	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
U876_RS03340	COG1051	belongs to the nudix hydrolase family
U876_RS03345	COG2130	NADP-dependent
U876_RS03350	COG1764	response to oxidative stress
U876_RS03355	COG1846	Transcriptional regulator
U876_RS03385	COG0561	phosphatase activity
U876_RS03400	COG0733	neurotransmitter:sodium symporter activity
U876_RS03410	COG0733	neurotransmitter:sodium symporter activity
U876_RS03435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U876_RS03450	COG1794	racemase activity, acting on amino acids and derivatives
U876_RS03465	COG2731	YhcH YjgK YiaL family protein
U876_RS03475	COG0668	transmembrane transport
U876_RS03485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
U876_RS03520	COG0583	DNA-binding transcription factor activity
U876_RS03525	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
U876_RS03535	COG0488	(ABC) transporter
U876_RS03540	COG0517	IMP dehydrogenase activity
U876_RS03540	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
U876_RS03545	COG1585	Membrane protein implicated in regulation of membrane protease activity
U876_RS03550	COG0330	HflC and HflK could
U876_RS03555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
U876_RS03555	COG1648	precorrin-2 dehydrogenase activity
U876_RS03560	COG0175	sulfate reduction
U876_RS03565	COG2895	sulfate adenylyltransferase (ATP) activity
U876_RS03570	COG0471	metal ion transport
U876_RS03570	COG3273	potassium ion transport
U876_RS03575	COG0529	Catalyzes the synthesis of activated sulfate
U876_RS03595	COG0840	transmembrane signaling receptor activity
U876_RS03615	COG1136	(ABC) transporter
U876_RS03630	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
U876_RS03645	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
U876_RS03650	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
U876_RS03655	COG0163	prenyltransferase activity
U876_RS03670	COG1131	(ABC) transporter
U876_RS03675	COG0842	Transport permease protein
U876_RS03680	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
U876_RS03685	COG1924	4 iron, 4 sulfur cluster binding
U876_RS03705	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
U876_RS03710	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
U876_RS03725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
U876_RS03730	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
U876_RS03735	COG1489	DNA binding
U876_RS03745	COG1643	Atp-dependent helicase
U876_RS03750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
U876_RS03755	COG0346	lactoylglutathione lyase activity
U876_RS03765	COG2076	Multidrug Resistance protein
U876_RS03775	COG3437	response regulator, receiver
U876_RS03775	COG0784	Response regulator, receiver
U876_RS03785	COG0671	phosphoesterase, PA-phosphatase related
U876_RS03800	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
U876_RS03805	COG0038	chloride channel
U876_RS03815	COG0316	Belongs to the HesB IscA family
U876_RS03840	COG1280	lysine exporter protein (LysE YggA)
U876_RS03845	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
U876_RS03860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U876_RS03890	COG0745	RESPONSE REGULATOR receiver
U876_RS03895	COG3104	oligopeptide transport
U876_RS03900	COG1210	Utp--glucose-1-phosphate uridylyltransferase
U876_RS03905	COG1555	photosystem II stabilization
U876_RS03915	COG2350	Protein conserved in bacteria
U876_RS03920	COG2917	probably involved in intracellular septation
U876_RS03925	COG0076	glutamate decarboxylase activity
U876_RS03930	COG1272	protein, Hemolysin III
U876_RS03935	COG0569	domain protein
U876_RS03935	COG2985	domain, Protein
U876_RS03945	COG0784	Response regulator, receiver
U876_RS03945	COG0835	chemotaxis
U876_RS03950	COG2755	lipolytic protein G-D-S-L family
U876_RS03955	COG4181	ATPase activity
U876_RS03960	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
U876_RS03965	COG1090	epimerase
U876_RS03970	COG2200	EAL domain
U876_RS03975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U876_RS03980	COG2234	aminopeptidase activity
U876_RS03980	COG4935	Belongs to the peptidase S8 family
U876_RS03985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
U876_RS03990	COG3171	Protein conserved in bacteria
U876_RS03995	COG2066	Belongs to the glutaminase family
U876_RS04000	COG2897	thiosulfate sulfurtransferase activity
U876_RS04005	COG1404	Belongs to the peptidase S8 family
U876_RS04015	COG1132	(ABC) transporter
U876_RS04040	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
U876_RS04045	COG5001	Diguanylate cyclase
U876_RS04045	COG3300	MHYT domain
U876_RS04065	COG4628	conserved protein (DUF2132)
U876_RS04070	COG0688	phosphatidylethanolamine metabolic process
U876_RS04075	COG1162	GTPase activity
U876_RS04080	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
U876_RS04110	COG1278	Cold shock
U876_RS04120	COG0840	transmembrane signaling receptor activity
U876_RS04125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
U876_RS04130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
U876_RS04175	COG0848	biopolymer transport protein
U876_RS04180	COG0811	peptide transport
U876_RS04185	COG0811	peptide transport
U876_RS04200	COG4174	ABC transporter (Permease)
U876_RS04205	COG4239	(ABC) transporter, permease
U876_RS04215	COG0444	Belongs to the ABC transporter superfamily
U876_RS04220	COG4608	Belongs to the ABC transporter superfamily
U876_RS04225	COG2195	Cleaves the N-terminal amino acid of tripeptides
U876_RS04230	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
U876_RS04235	COG1073	alpha beta
U876_RS04250	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
U876_RS04275	COG0243	molybdopterin cofactor binding
U876_RS04290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
U876_RS04290	COG1116	anion transmembrane transporter activity
U876_RS04295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
U876_RS04300	COG1116	anion transmembrane transporter activity
U876_RS04305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
U876_RS04305	COG2146	nitrite reductase [NAD(P)H] activity
U876_RS04310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
U876_RS04310	COG2146	nitrite reductase [NAD(P)H] activity
U876_RS04315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U876_RS04320	COG2313	pseudouridylate synthase activity
U876_RS04330	COG1858	cytochrome C peroxidase
U876_RS04365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
U876_RS04370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
U876_RS04395	COG2986	histidine ammonia-lyase
U876_RS04420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
U876_RS04430	COG1028	Short-chain dehydrogenase reductase Sdr
U876_RS04445	COG0521	Mo-molybdopterin cofactor biosynthetic process
U876_RS04455	COG2966	Psort location CytoplasmicMembrane, score
U876_RS04460	COG3610	response to peptide
U876_RS04470	COG4175	Glycine betaine
U876_RS04475	COG4176	ABC-type proline glycine betaine transport system permease component
U876_RS04480	COG2113	Glycine betaine
U876_RS04485	COG0175	sulfate reduction
U876_RS04490	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
U876_RS04495	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
U876_RS04500	COG0384	phenazine biosynthesis protein PhzF
U876_RS04505	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
U876_RS04510	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
U876_RS04520	COG0786	glutamate:sodium symporter activity
U876_RS04525	COG0252	asparaginase activity
U876_RS04530	COG3139	Protein of unknown function (DUF1315)
U876_RS04550	COG0616	signal peptide processing
U876_RS04555	COG0446	pyridine nucleotide-disulphide oxidoreductase
U876_RS04555	COG1902	pentaerythritol trinitrate reductase activity
U876_RS04560	COG0778	Nitroreductase
U876_RS04575	COG2264	protein methyltransferase activity
U876_RS04580	COG0604	alcohol dehydrogenase
U876_RS04585	COG0583	DNA-binding transcription factor activity
U876_RS04590	COG2190	(PTS) system
U876_RS04590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U876_RS04590	COG1263	PTS System
U876_RS04595	COG4145	pantothenate transmembrane transporter activity
U876_RS04605	COG0439	Biotin carboxylase
U876_RS04610	COG0511	ligase activity, forming carbon-carbon bonds
U876_RS04615	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
U876_RS04620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
U876_RS04630	COG3300	MHYT domain
U876_RS04630	COG5001	Diguanylate cyclase
U876_RS04650	COG3381	protein complex oligomerization
U876_RS04665	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
U876_RS04680	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
U876_RS04685	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
U876_RS04685	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
U876_RS04705	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
U876_RS04710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
U876_RS04715	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
U876_RS04720	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
U876_RS04725	COG4172	Belongs to the ABC transporter superfamily
U876_RS04735	COG0601	transmembrane transport
U876_RS04745	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
U876_RS04750	COG0142	geranyltranstransferase activity
U876_RS04755	COG1722	exodeoxyribonuclease VII activity
U876_RS04760	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
U876_RS04765	COG1360	Flagellar Motor Protein
U876_RS04780	COG1534	Rna-binding protein
U876_RS04785	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
U876_RS04795	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
U876_RS04800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
U876_RS04805	COG0149	triose-phosphate isomerase activity
U876_RS04810	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
U876_RS04825	COG0779	Required for maturation of 30S ribosomal subunits
U876_RS04830	COG0195	Participates in both transcription termination and antitermination
U876_RS04835	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
U876_RS04840	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
U876_RS04845	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
U876_RS04850	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
U876_RS04855	COG1185	polyribonucleotide nucleotidyltransferase activity
U876_RS04870	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
U876_RS04880	COG0114	fumarate hydratase activity
U876_RS04890	COG1966	Carbon starvation protein
U876_RS04895	COG3279	Response regulator of the LytR AlgR family
U876_RS04965	COG0312	modulator of DNA gyrase
U876_RS04970	COG0312	modulator of DNA gyrase
U876_RS04980	COG4974	Belongs to the 'phage' integrase family
U876_RS04985	COG1970	mechanosensitive ion channel activity
U876_RS04990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
U876_RS05000	COG0789	Transcriptional regulator
U876_RS05015	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
U876_RS05020	COG3545	Serine hydrolase
U876_RS05030	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
U876_RS05035	COG0321	lipoyl(octanoyl) transferase activity
U876_RS05040	COG2921	Belongs to the UPF0250 family
U876_RS05045	COG1686	Belongs to the peptidase S11 family
U876_RS05050	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
U876_RS05055	COG2951	lytic endotransglycosylase activity
U876_RS05060	COG0772	Belongs to the SEDS family
U876_RS05065	COG0768	penicillin binding
U876_RS05070	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
U876_RS05075	COG0799	negative regulation of ribosome biogenesis
U876_RS05080	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
U876_RS05095	COG0495	leucyl-tRNA aminoacylation
U876_RS05100	COG2888	peptidyl-tyrosine sulfation
U876_RS05105	COG0815	Transfers the fatty acyl group on membrane lipoproteins
U876_RS05110	COG4535	Mg2 and Co2 transporter CorC
U876_RS05115	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
U876_RS05120	COG1702	phosphate starvation-inducible protein PhoH
U876_RS05125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
U876_RS05130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
U876_RS05135	COG1335	isochorismatase
U876_RS05145	COG3706	GGDEF domain
U876_RS05160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U876_RS05180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
U876_RS05190	COG3647	Membrane
U876_RS05195	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
U876_RS05205	COG0516	GMP reductase activity
U876_RS05215	COG0642	Histidine kinase
U876_RS05255	COG3214	Protein conserved in bacteria
U876_RS05280	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
U876_RS05285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
U876_RS05290	COG1053	succinate dehydrogenase
U876_RS05300	COG0584	glycerophosphoryl diester phosphodiesterase
U876_RS05305	COG1511	domain protein
U876_RS05305	COG3264	Mechanosensitive ion channel
U876_RS05315	COG0739	heme binding
U876_RS05330	COG0583	DNA-binding transcription factor activity
U876_RS05350	COG0583	DNA-binding transcription factor activity
U876_RS05355	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
U876_RS05385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
U876_RS05390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
U876_RS05400	COG0338	D12 class N6 adenine-specific DNA methyltransferase
U876_RS05405	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
U876_RS05415	COG0180	Tryptophanyl-tRNA synthetase
U876_RS05430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
U876_RS05440	COG1012	belongs to the aldehyde dehydrogenase family
U876_RS05450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U876_RS05460	COG0674	pyruvate-flavodoxin oxidoreductase activity
U876_RS05460	COG1013	pyruvate-flavodoxin oxidoreductase activity
U876_RS05460	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
U876_RS05460	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
U876_RS05490	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
U876_RS05500	COG0490	domain, Protein
U876_RS05500	COG0471	metal ion transport
U876_RS05545	COG0012	GTP binding
U876_RS05550	COG0193	aminoacyl-tRNA hydrolase activity
U876_RS05555	COG0737	Belongs to the 5'-nucleotidase family
U876_RS05560	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
U876_RS05575	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
U876_RS05580	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
U876_RS05585	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
U876_RS05590	COG2890	protein-(glutamine-N5) methyltransferase activity
U876_RS05600	COG2912	Transglutaminase-like superfamily
U876_RS05605	COG2877	3-deoxy-8-phosphooctulonate synthase activity
U876_RS05610	COG1301	dicarboxylic acid transport
U876_RS05620	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
U876_RS05635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
U876_RS05640	COG1115	amino acid carrier protein
U876_RS05655	COG0714	Associated with various cellular activities
U876_RS05665	COG3104	oligopeptide transport
U876_RS05670	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
U876_RS05675	COG1678	Uncharacterized ACR, COG1678
U876_RS05685	COG0189	ligase activity
U876_RS05690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
U876_RS05700	COG3091	SprT-like family
U876_RS05710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
U876_RS05720	COG2200	EAL domain
U876_RS05745	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
U876_RS05750	COG0739	heme binding
U876_RS05755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
U876_RS05760	COG3408	Glycogen debranching enzyme
U876_RS05760	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
U876_RS05770	COG1881	PFAM PEBP family protein
U876_RS05775	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
U876_RS05780	COG0583	DNA-binding transcription factor activity
U876_RS05790	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
U876_RS05800	COG0583	DNA-binding transcription factor activity
U876_RS05805	COG1028	Short-chain dehydrogenase reductase Sdr
U876_RS05810	COG0616	signal peptide processing
U876_RS05815	COG3724	N-succinylarginine dihydrolase activity
U876_RS05835	COG0840	transmembrane signaling receptor activity
U876_RS05845	COG2971	BadF BadG BcrA BcrD
U876_RS05855	COG4608	Belongs to the ABC transporter superfamily
U876_RS05860	COG0444	Belongs to the ABC transporter superfamily
U876_RS05865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U876_RS05870	COG0601	transmembrane transport
U876_RS05875	COG4166	transmembrane transport
U876_RS05880	COG2205	protein histidine kinase activity
U876_RS05880	COG0784	Response regulator, receiver
U876_RS05910	COG3220	belongs to the UPF0276 family
U876_RS05940	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
U876_RS05945	COG1289	transmembrane transporter activity
U876_RS05950	COG0303	'Molybdopterin
U876_RS05955	COG0746	molybdenum cofactor guanylyltransferase activity
U876_RS05965	COG4662	Binding-protein-dependent transport system inner membrane component
U876_RS05975	COG2204	response regulator
U876_RS05980	COG3852	Histidine kinase
U876_RS05985	COG1910	domain protein
U876_RS05990	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
U876_RS06025	COG3383	formate dehydrogenase (NAD+) activity
U876_RS06025	COG3383	formate dehydrogenase (NAD+) activity
U876_RS06030	COG0437	4 iron, 4 sulfur cluster binding
U876_RS06045	COG0281	malic enzyme
U876_RS06065	COG2706	6-phosphogluconolactonase activity
U876_RS06075	COG1196	nuclear chromosome segregation
U876_RS06075	COG3264	Mechanosensitive ion channel
U876_RS06080	COG0469	pyruvate kinase activity
U876_RS06095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
U876_RS06095	COG4651	solute:proton antiporter activity
U876_RS06105	COG2974	May be involved in recombination
U876_RS06115	COG0420	3'-5' exonuclease activity
U876_RS06120	COG0419	ATPase involved in DNA repair
U876_RS06135	COG3038	cytochrome b561
U876_RS06150	COG2190	(PTS) system
U876_RS06160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
U876_RS06165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
U876_RS06170	COG0542	response to heat
U876_RS06185	COG1720	tRNA m6t6A37 methyltransferase activity
U876_RS06205	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
U876_RS06210	COG4988	ABC transporter
U876_RS06225	COG0745	RESPONSE REGULATOR receiver
U876_RS06235	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
U876_RS06250	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
U876_RS06255	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
U876_RS06265	COG0083	homoserine kinase activity
U876_RS06270	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
U876_RS06275	COG4319	ketosteroid isomerase
U876_RS06290	COG0488	(ABC) transporter
U876_RS06300	COG0813	purine-nucleoside phosphorylase activity
U876_RS06315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U876_RS06315	COG2205	protein histidine kinase activity
U876_RS06320	COG3384	dioxygenase
U876_RS06330	COG1283	sodium-dependent phosphate transmembrane transporter activity
U876_RS06340	COG0531	amino acid
U876_RS06350	COG0531	amino acid
U876_RS06365	COG1917	Cupin 2, conserved barrel domain protein
U876_RS06365	COG1396	sequence-specific DNA binding
U876_RS06370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
U876_RS06390	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
U876_RS06400	COG2375	cellular response to nickel ion
U876_RS06410	COG0577	efflux transmembrane transporter activity
U876_RS06410	COG1136	(ABC) transporter
U876_RS06415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U876_RS06425	COG1227	inorganic diphosphatase activity
U876_RS06435	COG0497	DNA recombination
U876_RS06440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
U876_RS06445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
U876_RS06450	COG0443	Heat shock 70 kDa protein
U876_RS06455	COG0484	heat shock protein binding
U876_RS06485	COG1285	pathogenesis
U876_RS06500	COG0640	Transcriptional regulator
U876_RS06530	COG0095	Lipoate-protein ligase
U876_RS06550	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U876_RS06555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U876_RS06575	COG0708	Exodeoxyribonuclease III
U876_RS06635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
U876_RS06640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
U876_RS06645	COG1845	cytochrome c oxidase, subunit III
U876_RS06650	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
U876_RS06655	COG0109	protoheme IX farnesyltransferase activity
U876_RS06660	COG2814	Major facilitator Superfamily
U876_RS06670	COG2175	clavaminate synthase activity
U876_RS06675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
U876_RS06680	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
U876_RS06685	COG4521	taurine ABC transporter
U876_RS06695	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
U876_RS06715	COG1988	membrane-bound metal-dependent
U876_RS06720	COG0159	tryptophan synthase activity
U876_RS06725	COG0133	tryptophan synthase activity
U876_RS06730	COG0135	phosphoribosylanthranilate isomerase activity
U876_RS06730	COG0134	indole-3-glycerol-phosphate synthase activity
U876_RS06735	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
U876_RS06740	COG0512	Glutamine amidotransferase of anthranilate synthase
U876_RS06740	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
U876_RS06745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
U876_RS06755	COG0009	L-threonylcarbamoyladenylate synthase
U876_RS06765	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
U876_RS06775	COG1946	Acyl-CoA thioesterase
U876_RS06790	COG1309	transcriptional regulator
U876_RS06795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U876_RS06800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U876_RS06815	COG1091	dTDP-4-dehydrorhamnose reductase activity
U876_RS06850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
U876_RS06870	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
U876_RS06900	COG1086	Polysaccharide biosynthesis protein
U876_RS06930	COG3206	protein involved in exopolysaccharide biosynthesis
U876_RS06930	COG0489	protein tyrosine kinase activity
U876_RS06935	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U876_RS06945	COG3132	Protein of unknown function, DUF480
U876_RS06985	COG1278	Cold shock
U876_RS07015	COG0697	spore germination
U876_RS07020	COG1349	DNA-binding transcription factor activity
U876_RS07025	COG1882	Formate acetyltransferase
U876_RS07030	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
U876_RS07035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
U876_RS07065	COG0622	Phosphoesterase
U876_RS07080	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
U876_RS07085	COG0784	Response regulator, receiver
U876_RS07085	COG0835	chemotaxis
U876_RS07090	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
U876_RS07095	COG1815	bacterial-type flagellum-dependent cell motility
U876_RS07115	COG4787	bacterial-type flagellum-dependent cell motility
U876_RS07125	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
U876_RS07130	COG1706	bacterial-type flagellum-dependent cell motility
U876_RS07135	COG1705	Flagellar rod assembly protein muramidase FlgJ
U876_RS07135	COG3951	Flagellar rod assembly protein muramidase FlgJ
U876_RS07140	COG1256	bacterial-type flagellum assembly
U876_RS07150	COG2239	Acts as a magnesium transporter
U876_RS07160	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
U876_RS07165	COG2716	regulation of RNA biosynthetic process
U876_RS07190	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
U876_RS07195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
U876_RS07200	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
U876_RS07205	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
U876_RS07225	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
U876_RS07235	COG0590	tRNA wobble adenosine to inosine editing
U876_RS07240	COG0573	inorganic phosphate transmembrane transporter activity
U876_RS07245	COG0581	inorganic phosphate transmembrane transporter activity
U876_RS07250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
U876_RS07255	COG0704	Plays a role in the regulation of phosphate uptake
U876_RS07260	COG1253	flavin adenine dinucleotide binding
U876_RS07275	COG0531	amino acid
U876_RS07290	COG1126	abc transporter atp-binding protein
U876_RS07295	COG0765	amino acid transport
U876_RS07300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U876_RS07310	COG2271	Major facilitator Superfamily
U876_RS07325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
U876_RS07355	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
U876_RS07360	COG0477	Major facilitator Superfamily
U876_RS07365	COG0123	including yeast histone deacetylase and acetoin utilization protein
U876_RS07375	COG1199	ATP-dependent helicase activity
U876_RS07390	COG1448	Aminotransferase
U876_RS07395	COG0433	COG0433 Predicted ATPase
U876_RS07470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
U876_RS07480	COG1522	sequence-specific DNA binding
U876_RS07505	COG5642	Protein of unknown function (DUF2384)
U876_RS07510	COG2916	Histone family protein nucleoid-structuring protein H-NS
U876_RS07545	COG2333	competence protein COMEC
U876_RS07545	COG0658	competence protein
U876_RS07555	COG1663	tetraacyldisaccharide 4'-kinase activity
U876_RS07560	COG2835	tetraacyldisaccharide 4'-kinase activity
U876_RS07565	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
U876_RS07570	COG2197	response regulator
U876_RS07575	COG0322	excinuclease ABC activity
U876_RS07600	COG0582	viral genome integration into host DNA
U876_RS07620	COG4372	Transposase
U876_RS07640	COG3962	Belongs to the TPP enzyme family
U876_RS07650	COG0673	inositol 2-dehydrogenase activity
U876_RS07655	COG1879	ABC-type sugar transport system periplasmic component
U876_RS07665	COG1172	Belongs to the binding-protein-dependent transport system permease family
U876_RS07670	COG0673	inositol 2-dehydrogenase activity
U876_RS07675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U876_RS07685	COG3718	enzyme involved in inositol metabolism
U876_RS07690	COG3039	Transposase
U876_RS07765	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
U876_RS07770	COG0437	4 iron, 4 sulfur cluster binding
U876_RS07775	COG3301	Polysulphide reductase, NrfD
U876_RS07780	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
U876_RS07790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
U876_RS07795	COG0215	cysteine-tRNA ligase activity
U876_RS07810	COG2203	Gaf domain
U876_RS07810	COG2199	diguanylate cyclase activity
U876_RS07840	COG2119	membrane
U876_RS07845	COG0023	Translation Initiation Factor
U876_RS07870	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
U876_RS07885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U876_RS07885	COG2205	protein histidine kinase activity
U876_RS07895	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
U876_RS07905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
U876_RS07910	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
U876_RS07915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
U876_RS07920	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
U876_RS07925	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
U876_RS07930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
U876_RS07940	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
U876_RS07945	COG0505	Belongs to the CarA family
U876_RS07950	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
U876_RS07955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
U876_RS07985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U876_RS07990	COG0513	Belongs to the DEAD box helicase family
U876_RS08000	COG4104	PAAR repeat-containing protein
U876_RS08015	COG0789	Transcriptional regulator
U876_RS08030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U876_RS08035	COG0765	amino acid transport
U876_RS08040	COG1126	abc transporter atp-binding protein
U876_RS08045	COG0493	'glutamate synthase
U876_RS08050	COG0069	glutamate synthase activity
U876_RS08050	COG0067	glutamate synthase
U876_RS08050	COG0070	glutamate synthase
U876_RS08055	COG1242	4 iron, 4 sulfur cluster binding
U876_RS08115	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
U876_RS08120	COG0574	Belongs to the PEP-utilizing enzyme family
U876_RS08120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
U876_RS08165	COG1464	Belongs to the NlpA lipoprotein family
U876_RS08170	COG0671	phosphoesterase, PA-phosphatase related
U876_RS08175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
U876_RS08180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
U876_RS08190	COG0101	tRNA pseudouridine synthase activity
U876_RS08195	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
U876_RS08200	COG0285	dihydrofolate synthase activity
U876_RS08205	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
U876_RS08210	COG2920	part of a sulfur-relay system
U876_RS08215	COG1289	transmembrane transporter activity
U876_RS08220	COG0670	Belongs to the BI1 family
U876_RS08240	COG2194	sulfuric ester hydrolase activity
U876_RS08250	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
U876_RS08250	COG0392	lysyltransferase activity
U876_RS08260	COG0840	transmembrane signaling receptor activity
U876_RS08265	COG5001	Diguanylate cyclase
U876_RS08270	COG0564	pseudouridine synthase activity
U876_RS08285	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
U876_RS08295	COG0625	glutathione transferase activity
U876_RS08300	COG0625	glutathione transferase activity
U876_RS08310	COG0367	asparagine synthase
U876_RS08320	COG4651	solute:proton antiporter activity
U876_RS08320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
U876_RS08325	COG0647	UMP catabolic process
U876_RS08330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
U876_RS08335	COG1902	pentaerythritol trinitrate reductase activity
U876_RS08340	COG1253	flavin adenine dinucleotide binding
U876_RS08350	COG0247	lactate metabolic process
U876_RS08350	COG0277	FAD linked oxidase domain protein
U876_RS08360	COG2050	protein possibly involved in aromatic compounds catabolism
U876_RS08370	COG2056	Na+-H+ antiporter family
U876_RS08375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
U876_RS08390	COG0346	lactoylglutathione lyase activity
U876_RS08395	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
U876_RS08400	COG4660	Part of a membrane complex involved in electron transport
U876_RS08405	COG4659	FMN binding
U876_RS08410	COG4658	electron transport chain
U876_RS08420	COG2878	Part of a membrane complex involved in electron transport
U876_RS08425	COG4657	Part of a membrane complex involved in electron transport
U876_RS08430	COG0697	spore germination
U876_RS08445	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
U876_RS08450	COG1288	antiporter activity
U876_RS08455	COG0436	Aminotransferase
U876_RS08465	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
U876_RS08470	COG2027	D-alanyl-D-alanine carboxypeptidase
U876_RS08475	COG1061	Type III restriction enzyme res subunit
U876_RS08480	COG1566	PFAM secretion protein HlyD family protein
U876_RS08490	COG1966	Carbon starvation protein
U876_RS08495	COG3279	Response regulator of the LytR AlgR family
U876_RS08500	COG3275	phosphorelay sensor kinase activity
U876_RS08505	COG2199	diguanylate cyclase activity
U876_RS08505	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
U876_RS08510	COG1454	alcohol dehydrogenase
U876_RS08510	COG1012	belongs to the aldehyde dehydrogenase family
U876_RS08520	COG2095	MarC family integral membrane protein
U876_RS08530	COG0601	transmembrane transport
U876_RS08535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U876_RS08555	COG0861	Integral membrane protein TerC family
U876_RS08560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
U876_RS08570	COG1301	dicarboxylic acid transport
U876_RS08585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
U876_RS08590	COG0582	viral genome integration into host DNA
U876_RS08635	COG2974	May be involved in recombination
U876_RS08665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
U876_RS08785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
U876_RS08790	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
U876_RS08960	COG0537	adenosine 5'-monophosphoramidase activity
U876_RS08995	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
U876_RS09000	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
U876_RS09010	COG2354	Protein conserved in bacteria
U876_RS09025	COG2233	PERMEase
U876_RS09030	COG3150	esterase
U876_RS09035	COG1252	NADH dehydrogenase
U876_RS09055	COG0393	Putative heavy-metal-binding
U876_RS09065	COG1648	precorrin-2 dehydrogenase activity
U876_RS09065	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
U876_RS09085	COG4667	esterase of the alpha-beta hydrolase superfamily
U876_RS09090	COG1619	proteins homologs of microcin C7 resistance protein MccF
U876_RS09095	COG1368	sulfuric ester hydrolase activity
U876_RS09105	COG0527	aspartate kinase activity
U876_RS09110	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
U876_RS09110	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
U876_RS09115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
U876_RS09140	COG0596	Alpha beta hydrolase
U876_RS09145	COG0346	lactoylglutathione lyase activity
U876_RS09155	COG0583	DNA-binding transcription factor activity
U876_RS09160	COG1620	l-lactate permease
U876_RS09170	COG1139	Iron-sulfur cluster binding protein
U876_RS09190	COG0577	efflux transmembrane transporter activity
U876_RS09195	COG1136	(ABC) transporter
U876_RS09205	COG2814	Major facilitator Superfamily
U876_RS09225	COG0672	)-iron permease
U876_RS09255	COG0659	secondary active sulfate transmembrane transporter activity
U876_RS09320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
U876_RS09325	COG0840	transmembrane signaling receptor activity
U876_RS09335	COG2201	protein-glutamate methylesterase activity
U876_RS09345	COG0835	chemotaxis
U876_RS09350	COG3290	protein histidine kinase activity
U876_RS09350	COG0840	transmembrane signaling receptor activity
U876_RS09355	COG0643	Histidine kinase
U876_RS09355	COG2198	Histidine kinase
U876_RS09365	COG0745	RESPONSE REGULATOR receiver
U876_RS09370	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
U876_RS09375	COG0437	4 iron, 4 sulfur cluster binding
U876_RS09380	COG5557	Pfam Polysulphide reductase, NrfD
U876_RS09385	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
U876_RS09390	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
U876_RS09395	COG1773	rubredoxin
U876_RS09400	COG0747	negative chemotaxis
U876_RS09405	COG0601	transmembrane transport
U876_RS09410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U876_RS09415	COG0444	Belongs to the ABC transporter superfamily
U876_RS09420	COG3842	ATPase activity
U876_RS09425	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
U876_RS09430	COG0375	protein maturation
U876_RS09435	COG0309	Hydrogenase expression formation protein (HypE)
U876_RS09445	COG0298	carbon dioxide binding
U876_RS09450	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
U876_RS09460	COG1921	L-seryl-tRNASec selenium transferase activity
U876_RS09465	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
U876_RS09475	COG3260	NADH ubiquinone oxidoreductase 20
U876_RS09480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
U876_RS09485	COG3261	NADH dehydrogenase
U876_RS09485	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
U876_RS09490	COG0650	Formate hydrogenlyase subunit 4
U876_RS09495	COG0651	ATP synthesis coupled electron transport
U876_RS09500	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
U876_RS09505	COG3158	transport of potassium into the cell
U876_RS09510	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
U876_RS09515	COG3383	formate dehydrogenase (NAD+) activity
U876_RS09520	COG3383	formate dehydrogenase (NAD+) activity
U876_RS09540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
U876_RS09545	COG0326	Molecular chaperone. Has ATPase activity
U876_RS09550	COG0563	adenylate kinase activity
U876_RS09555	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
U876_RS09565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U876_RS09580	COG5001	Diguanylate cyclase
U876_RS09580	COG3300	MHYT domain
U876_RS09585	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
U876_RS09605	COG1021	2,3-dihydroxybenzoate-AMP ligase
U876_RS09610	COG1535	isochorismatase
U876_RS09610	COG3433	isochorismatase activity
U876_RS09615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U876_RS09620	COG1028	Short-chain dehydrogenase reductase Sdr
U876_RS09630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U876_RS09635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
U876_RS09640	COG2977	Belongs to the P-Pant transferase superfamily
U876_RS09645	COG1120	ATPase activity
U876_RS09650	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U876_RS09655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U876_RS09660	COG4771	TonB-dependent receptor
U876_RS09700	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
U876_RS09705	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
U876_RS09710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
U876_RS09725	COG1570	exodeoxyribonuclease VII activity
U876_RS09730	COG0697	spore germination
U876_RS09750	COG3158	transport of potassium into the cell
U876_RS09755	COG0516	GMP reductase activity
U876_RS09755	COG0517	IMP dehydrogenase activity
U876_RS09760	COG0519	Catalyzes the synthesis of GMP from XMP
U876_RS09760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
U876_RS09765	COG0582	viral genome integration into host DNA
U876_RS09815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
U876_RS09815	COG2169	Transcriptional regulator
U876_RS09840	COG2062	phosphohistidine phosphatase, SixA
U876_RS09850	COG0697	spore germination
U876_RS09855	COG4166	transmembrane transport
U876_RS09860	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
U876_RS09865	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
U876_RS09875	COG4591	ABC-type transport system involved in lipoprotein release permease component
U876_RS09880	COG1136	(ABC) transporter
U876_RS09885	COG4591	ABC-type transport system involved in lipoprotein release permease component
U876_RS09890	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
U876_RS09900	COG0544	peptidyl-prolyl cis-trans isomerase activity
U876_RS09905	COG0740	serine-type endopeptidase activity
U876_RS09910	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
U876_RS09915	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
U876_RS09925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
U876_RS09930	COG0488	(ABC) transporter
U876_RS09935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
U876_RS09940	COG3162	membrane
U876_RS09955	COG1024	Enoyl-CoA hydratase
U876_RS09990	COG1115	amino acid carrier protein
U876_RS10005	COG1584	GPR1 FUN34 yaaH family protein
U876_RS10040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
U876_RS10045	COG1960	acyl-CoA dehydrogenase activity
U876_RS10055	COG1960	acyl-CoA dehydrogenase activity
U876_RS10060	COG1024	Enoyl-CoA hydratase
U876_RS10065	COG1024	Enoyl-CoA hydratase
U876_RS10075	COG1028	Short-chain dehydrogenase reductase Sdr
U876_RS10085	COG0730	response to heat
U876_RS10105	COG5002	protein histidine kinase activity
U876_RS10105	COG5001	Diguanylate cyclase
U876_RS10115	COG2003	Belongs to the UPF0758 family
U876_RS10125	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
U876_RS10140	COG1073	alpha beta
U876_RS10145	COG1506	peptidase
U876_RS10145	COG0823	Involved in the tonB-independent uptake of proteins
U876_RS10150	COG0702	epimerase
U876_RS10155	COG0583	DNA-binding transcription factor activity
U876_RS10160	COG0667	Aldo Keto reductase
U876_RS10175	COG3706	GGDEF domain
U876_RS10180	COG0583	DNA-binding transcription factor activity
U876_RS10185	COG2723	6-phospho-beta-galactosidase activity
U876_RS10190	COG5001	Diguanylate cyclase
U876_RS10190	COG3300	MHYT domain
U876_RS10200	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
U876_RS10205	COG1028	Short-chain dehydrogenase reductase Sdr
U876_RS10210	COG0583	DNA-binding transcription factor activity
U876_RS10215	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
U876_RS10220	COG0673	inositol 2-dehydrogenase activity
U876_RS10225	COG0583	DNA-binding transcription factor activity
U876_RS10235	COG1560	Kdo2-lipid A biosynthetic process
U876_RS10240	COG1560	Kdo2-lipid A biosynthetic process
U876_RS10265	COG0417	DNA replication proofreading
U876_RS10295	COG0534	Mate efflux family protein
U876_RS10305	COG0307	riboflavin synthase, alpha
U876_RS10315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U876_RS10320	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
U876_RS10325	COG0697	spore germination
U876_RS10330	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
U876_RS10370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
U876_RS10375	COG3099	Belongs to the UPF0263 family
U876_RS10380	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
U876_RS10385	COG2894	cell division
U876_RS10390	COG0850	regulation of cytokinetic process
U876_RS10395	COG3100	YcgL domain-containing protein
U876_RS10400	COG2951	lytic endotransglycosylase activity
U876_RS10405	COG1760	l-serine dehydratase
U876_RS10410	COG1760	l-serine dehydratase
U876_RS10415	COG3123	guanosine phosphorylase activity
U876_RS10435	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
U876_RS10440	COG2067	long-chain fatty acid transport protein
U876_RS10455	COG1595	DNA-templated transcription, initiation
U876_RS10485	COG0714	Associated with various cellular activities
U876_RS10490	COG0183	Belongs to the thiolase family
U876_RS10495	COG1250	3-hydroxyacyl-CoA dehydrogenase
U876_RS10495	COG1024	Enoyl-CoA hydratase
U876_RS10525	COG4388	Caudovirus prohead serine protease
U876_RS10530	COG3829	transcription factor binding
U876_RS10535	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
U876_RS10540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
U876_RS10545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
U876_RS10555	COG0549	Belongs to the carbamate kinase family
U876_RS10560	COG0697	spore germination
U876_RS10565	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
U876_RS10565	COG3608	succinylglutamate desuccinylase aspartoacylase
U876_RS10570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
U876_RS10580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
U876_RS10580	COG0493	'glutamate synthase
U876_RS10585	COG0402	S-adenosylhomocysteine deaminase activity
U876_RS10590	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
U876_RS10595	COG2080	2 iron, 2 sulfur cluster binding
U876_RS10595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
U876_RS10600	COG2233	PERMEase
U876_RS10605	COG0402	S-adenosylhomocysteine deaminase activity
U876_RS10610	COG2252	PERMEase
U876_RS10615	COG1529	Aldehyde oxidase and xanthine dehydrogenase
U876_RS10620	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
U876_RS10625	COG2080	2 iron, 2 sulfur cluster binding
U876_RS10635	COG3134	Outer membrane lipoprotein
U876_RS10645	COG1288	antiporter activity
U876_RS10650	COG0318	PFAM AMP-dependent synthetase and ligase
U876_RS10655	COG0140	phosphoribosyl-ATP diphosphatase activity
U876_RS10655	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
U876_RS10660	COG0107	imidazoleglycerol-phosphate synthase activity
U876_RS10665	COG0784	Response regulator, receiver
U876_RS10665	COG2198	Histidine kinase
U876_RS10665	COG2205	protein histidine kinase activity
U876_RS10670	COG2199	diguanylate cyclase activity
U876_RS10675	COG3437	response regulator, receiver
U876_RS10680	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
U876_RS10685	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
U876_RS10690	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
U876_RS10690	COG0131	Imidazoleglycerol-phosphate dehydratase
U876_RS10695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
U876_RS10700	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
U876_RS10705	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
U876_RS10715	COG1199	ATP-dependent helicase activity
U876_RS10720	COG1214	PFAM Peptidase M22, glycoprotease
U876_RS10730	COG0596	Alpha beta hydrolase
U876_RS10730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
U876_RS10730	COG2226	methyltransferase
U876_RS10735	COG0318	PFAM AMP-dependent synthetase and ligase
U876_RS10740	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
U876_RS10850	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
U876_RS10860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
U876_RS10865	COG2832	Protein of unknown function (DUF454)
U876_RS10870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
U876_RS10880	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
U876_RS10915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
U876_RS11005	COG0753	catalase activity
U876_RS11035	COG3645	SOS response
U876_RS11035	COG3646	Phage regulatory protein
U876_RS11060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
U876_RS11065	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
U876_RS11080	COG2916	Histone family protein nucleoid-structuring protein H-NS
U876_RS11235	COG0617	tRNA 3'-terminal CCA addition
U876_RS11235	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
U876_RS11235	COG0517	IMP dehydrogenase activity
U876_RS11240	COG1643	Atp-dependent helicase
U876_RS11260	COG3437	response regulator, receiver
U876_RS11265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U876_RS11270	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
U876_RS11275	COG0709	Synthesizes selenophosphate from selenide and ATP
U876_RS11295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
U876_RS11300	COG0840	transmembrane signaling receptor activity
U876_RS11305	COG1254	Belongs to the acylphosphatase family
U876_RS11310	COG0625	glutathione transferase activity
U876_RS11315	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U876_RS11315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U876_RS11320	COG0489	protein tyrosine kinase activity
U876_RS11325	COG0572	uridine kinase
U876_RS11330	COG0717	Belongs to the dCTP deaminase family
U876_RS11335	COG0306	phosphate transporter
U876_RS11340	COG1530	ribonuclease E activity
U876_RS11345	COG0564	pseudouridine synthase activity
U876_RS11355	COG0424	maF-like protein
U876_RS11360	COG2814	Major facilitator Superfamily
U876_RS11375	COG1399	metal-binding, possibly nucleic acid-binding protein
U876_RS11380	COG0333	Belongs to the bacterial ribosomal protein bL32 family
U876_RS11385	COG0416	fatty acid biosynthetic process
U876_RS11390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
U876_RS11400	COG1028	Short-chain dehydrogenase reductase Sdr
U876_RS11405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
U876_RS11415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
U876_RS11420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
U876_RS11425	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
U876_RS11430	COG0470	DNA polymerase III
U876_RS11435	COG0084	hydrolase, TatD family'
U876_RS11450	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
U876_RS11450	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
U876_RS11455	COG3008	intermembrane lipid transfer
U876_RS11460	COG2995	paraquat-inducible protein a
U876_RS11470	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
U876_RS11475	COG0372	Belongs to the citrate synthase family
U876_RS11520	COG4221	oxidoreductase activity
U876_RS11530	COG3141	response to X-ray
U876_RS11540	COG1067	ATP-dependent peptidase activity
U876_RS11545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
U876_RS11555	COG0488	(ABC) transporter
U876_RS11565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
U876_RS11565	COG0116	Belongs to the methyltransferase superfamily
U876_RS11575	COG0167	dihydroorotate dehydrogenase activity
U876_RS11580	COG2902	Dehydrogenase
U876_RS11590	COG0308	aminopeptidase N
U876_RS11600	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
U876_RS11605	COG1956	GAF domain-containing protein
U876_RS11615	COG3278	Belongs to the heme-copper respiratory oxidase family
U876_RS11630	COG2010	Cytochrome c
U876_RS11655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
U876_RS11660	COG0589	response to stress
U876_RS11665	COG0037	tRNA processing
U876_RS11680	COG0625	glutathione transferase activity
U876_RS11685	COG1869	D-ribose catabolic process
U876_RS11690	COG1129	ABC transporter
U876_RS11695	COG1172	Belongs to the binding-protein-dependent transport system permease family
U876_RS11700	COG1879	ABC-type sugar transport system periplasmic component
U876_RS11705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U876_RS11710	COG1609	Transcriptional regulator
U876_RS11715	COG2199	diguanylate cyclase activity
U876_RS11745	COG0776	regulation of translation
U876_RS11750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U876_RS11750	COG0072	phenylalanine-tRNA ligase activity
U876_RS11755	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
U876_RS11760	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
U876_RS11765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
U876_RS11770	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
U876_RS11775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
U876_RS11795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
U876_RS11805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
U876_RS11810	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
U876_RS11815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
U876_RS11820	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
U876_RS11825	COG3313	Fe-S protein
U876_RS11830	COG2942	2-epimerase
U876_RS11835	COG3716	PTS system mannose fructose sorbose family IID component
U876_RS11840	COG3715	PTS system
U876_RS11845	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U876_RS11845	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
U876_RS11860	COG1609	Transcriptional regulator
U876_RS11865	COG2140	Oxalate decarboxylase
U876_RS11870	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
U876_RS11870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U876_RS11870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U876_RS11875	COG1105	Belongs to the carbohydrate kinase PfkB family
U876_RS11880	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
U876_RS11880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
U876_RS11885	COG1609	Transcriptional regulator
U876_RS11890	COG0814	amino acid
U876_RS11900	COG5654	RES domain protein
U876_RS11905	COG0513	Belongs to the DEAD box helicase family
U876_RS11915	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
U876_RS11920	COG2890	protein-(glutamine-N5) methyltransferase activity
U876_RS11925	COG2840	Smr protein MutS2
U876_RS11935	COG3706	GGDEF domain
U876_RS11940	COG0588	phosphoglycerate mutase activity
U876_RS11965	COG2824	Alkylphosphonate utilization operon protein PhnA
U876_RS11980	COG0384	phenazine biosynthesis protein PhzF
U876_RS11995	COG0242	peptide deformylase activity
U876_RS12015	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
U876_RS12020	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
U876_RS12030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
U876_RS12035	COG1434	Gram-negative-bacterium-type cell wall biogenesis
U876_RS12045	COG0205	6-phosphofructokinase activity
U876_RS12050	COG1473	amidohydrolase
U876_RS12055	COG1011	Hydrolase
U876_RS12060	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
U876_RS12090	COG3593	DNA synthesis involved in DNA repair
U876_RS12105	COG0583	DNA-binding transcription factor activity
U876_RS12110	COG0730	response to heat
U876_RS12115	COG3148	PFAM DTW domain containing protein
U876_RS12125	COG1181	Belongs to the D-alanine--D-alanine ligase family
U876_RS12135	COG0386	Belongs to the glutathione peroxidase family
U876_RS12140	COG0513	Belongs to the DEAD box helicase family
U876_RS12145	COG0456	acetyltransferase
U876_RS12155	COG1742	UPF0060 membrane protein
U876_RS12185	COG2329	Antibiotic biosynthesis monooxygenase
U876_RS12190	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
U876_RS12210	COG3243	poly(R)-hydroxyalkanoic acid synthase
U876_RS12220	COG2501	S4 domain
U876_RS12230	COG1132	(ABC) transporter
U876_RS12235	COG1132	(ABC) transporter
U876_RS12245	COG3118	belongs to the thioredoxin family
U876_RS12250	COG0471	metal ion transport
U876_RS12255	COG0058	SHG alpha-glucan phosphorylase activity
U876_RS12290	COG0814	amino acid
U876_RS12295	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
U876_RS12300	COG0514	ATP-dependent DNA helicase (RecQ)
U876_RS12305	COG2766	serine protein kinase
U876_RS12315	COG2719	SpoVR family
U876_RS12320	COG2186	Transcriptional regulator
U876_RS12325	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
U876_RS12330	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
U876_RS12335	COG0586	Pfam SNARE associated Golgi protein
U876_RS12345	COG0556	nucleotide-excision repair
U876_RS12355	COG0569	domain protein
U876_RS12355	COG2985	domain, Protein
U876_RS12360	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
U876_RS12380	COG4565	transcriptional regulatory protein
U876_RS12385	COG3290	protein histidine kinase activity
U876_RS12390	COG1940	carbohydrate kinase activity
U876_RS12390	COG1846	Transcriptional regulator
U876_RS12395	COG0840	transmembrane signaling receptor activity
U876_RS12400	COG3012	SEC-C Motif Domain Protein
U876_RS12405	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
U876_RS12410	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
U876_RS12415	COG0247	lactate metabolic process
U876_RS12435	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
U876_RS12440	COG0437	4 iron, 4 sulfur cluster binding
U876_RS12445	COG3301	Polysulphide reductase, NrfD
U876_RS12450	COG1138	Cytochrome C-type biogenesis protein
U876_RS12460	COG4235	cytochrome complex assembly
U876_RS12460	COG3088	subunit of a heme lyase
U876_RS12465	COG1051	belongs to the nudix hydrolase family
U876_RS12475	COG3033	Beta-eliminating lyase
U876_RS12480	COG3046	protein related to deoxyribodipyrimidine photolyase
U876_RS12485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
U876_RS12510	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
U876_RS12515	COG0583	DNA-binding transcription factor activity
U876_RS12525	COG4774	siderophore transport
U876_RS12530	COG4977	sequence-specific DNA binding
U876_RS12540	COG0583	DNA-binding transcription factor activity
U876_RS12545	COG2910	NAD(P)H-binding
U876_RS12555	COG0626	cystathionine gamma-synthase activity
U876_RS12560	COG0612	Peptidase, M16
U876_RS12565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
U876_RS12575	COG1944	ATP diphosphatase activity
U876_RS12580	COG2116	formate transmembrane transporter activity
U876_RS12585	COG1882	Formate acetyltransferase
U876_RS12590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U876_RS12600	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
U876_RS12610	COG1840	ABC-type Fe3 transport system, periplasmic component
U876_RS12615	COG3842	ATPase activity
U876_RS12625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
U876_RS12630	COG2983	Belongs to the UPF0260 family
U876_RS12640	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
U876_RS12645	COG0045	succinate-CoA ligase (ADP-forming) activity
U876_RS12650	COG0508	dehydrogenase complex catalyzes the overall conversion of
U876_RS12655	COG0567	Dehydrogenase, E1 component
U876_RS12665	COG1053	succinate dehydrogenase
U876_RS12670	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
U876_RS12695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
U876_RS12700	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
U876_RS12700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
U876_RS12710	COG3069	C4-dicarboxylate transmembrane transporter activity
U876_RS12725	COG1451	nucleotide metabolic process
U876_RS12740	COG0254	rRNA binding
U876_RS12745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
U876_RS12755	COG0583	DNA-binding transcription factor activity
U876_RS12765	COG1172	Belongs to the binding-protein-dependent transport system permease family
U876_RS12775	COG1879	ABC-type sugar transport system periplasmic component
U876_RS12780	COG1069	ribulokinase activity
U876_RS12790	COG2160	L-arabinose isomerase activity
U876_RS12795	COG2925	Exonuclease
U876_RS12805	COG3345	alpha-galactosidase
U876_RS12810	COG1380	Effector of murein hydrolase LrgA
U876_RS12815	COG1346	cytolysis
U876_RS12820	COG0295	cytidine deaminase activity
U876_RS12825	COG1022	Amp-dependent synthetase and ligase
U876_RS12840	COG0861	Integral membrane protein TerC family
U876_RS12845	COG2885	chlorophyll binding
U876_RS12850	COG2199	diguanylate cyclase activity
U876_RS12865	COG2154	pterin-4-alpha-carbinolamine dehydratase
U876_RS12870	COG2154	pterin-4-alpha-carbinolamine dehydratase
U876_RS12880	COG3768	UPF0283 membrane protein
U876_RS12885	COG3106	COG3106 Predicted ATPase
U876_RS12900	COG1842	Phage shock protein A
U876_RS12905	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
U876_RS12915	COG4168	peptide transport system, permease
U876_RS12920	COG4171	peptide transport system, permease
U876_RS12930	COG4172	Belongs to the ABC transporter superfamily
U876_RS12940	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
U876_RS12945	COG1286	toxin biosynthetic process
U876_RS12950	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
U876_RS12955	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
U876_RS12960	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
U876_RS12965	COG1674	ftsk spoiiie
U876_RS12965	COG0531	amino acid
U876_RS12975	COG0492	ferredoxin-NADP+ reductase activity
U876_RS12980	COG3706	GGDEF domain
U876_RS12985	COG3134	Outer membrane lipoprotein
U876_RS12990	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
U876_RS12995	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
U876_RS13000	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
U876_RS13005	COG0542	response to heat
U876_RS13010	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
U876_RS13015	COG1278	Cold shock
U876_RS13020	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
U876_RS13080	COG3829	transcription factor binding
U876_RS13155	COG3501	Rhs element vgr protein
U876_RS13180	COG1435	thymidine kinase activity
U876_RS13185	COG1757	Na H antiporter
U876_RS13190	COG2916	Histone family protein nucleoid-structuring protein H-NS
U876_RS13195	COG2096	Adenosyltransferase
U876_RS13200	COG3530	Putative quorum-sensing-regulated virulence factor
U876_RS13205	COG0602	queuosine metabolic process
U876_RS13210	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
U876_RS13230	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
U876_RS13240	COG0776	regulation of translation
U876_RS13245	COG0539	negative regulation of cytoplasmic translation
U876_RS13250	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
U876_RS13255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
U876_RS13265	COG0583	DNA-binding transcription factor activity
U876_RS13285	COG0778	Nitroreductase
U876_RS13290	COG5001	Diguanylate cyclase
U876_RS13290	COG3300	MHYT domain
U876_RS13300	COG0583	DNA-binding transcription factor activity
U876_RS13305	COG3437	response regulator, receiver
U876_RS13330	COG4989	oxidoreductase activity
U876_RS13335	COG0724	RNA recognition motif
U876_RS13355	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
U876_RS13370	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
U876_RS13375	COG1360	Flagellar Motor Protein
U876_RS13380	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
U876_RS13385	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
U876_RS13390	COG0649	NAD binding
U876_RS13390	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
U876_RS13405	COG1034	ATP synthesis coupled electron transport
U876_RS13410	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
U876_RS13415	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
U876_RS13420	COG0839	Belongs to the complex I subunit 6 family
U876_RS13425	COG0713	ATP synthesis coupled electron transport
U876_RS13435	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
U876_RS13440	COG1007	ATP synthesis coupled electron transport
U876_RS13450	COG0047	phosphoribosylformylglycinamidine synthase activity
U876_RS13450	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
U876_RS13455	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
U876_RS13460	COG1645	bacterial-type flagellum-dependent swarming motility
U876_RS13465	COG1160	GTP binding
U876_RS13470	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U876_RS13475	COG2976	Protein conserved in bacteria
U876_RS13480	COG0124	histidyl-tRNA synthetase
U876_RS13485	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
U876_RS13500	COG0820	rRNA (adenine-C2-)-methyltransferase activity
U876_RS13505	COG0105	UTP biosynthetic process
U876_RS13510	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
U876_RS13520	COG0633	Ferredoxin
U876_RS13525	COG0443	Heat shock 70 kDa protein
U876_RS13530	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
U876_RS13540	COG0822	iron-sulfur transferase activity
U876_RS13545	COG1104	cysteine desulfurase activity
U876_RS13565	COG3154	lipid carrier protein
U876_RS13570	COG0826	peptidase U32
U876_RS13575	COG0826	peptidase U32
U876_RS13590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
U876_RS13595	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
U876_RS13600	COG1862	Preprotein translocase
U876_RS13605	COG0343	queuine tRNA-ribosyltransferase activity
U876_RS13610	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
U876_RS13615	COG0517	IMP dehydrogenase activity
U876_RS13625	COG3634	alkyl hydroperoxide reductase activity
U876_RS13645	COG1393	Belongs to the ArsC family
U876_RS13650	COG0798	PFAM Bile acid sodium symporter
U876_RS13655	COG0640	Transcriptional regulator
U876_RS13660	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
U876_RS13660	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
U876_RS13665	COG0509	glycine decarboxylation via glycine cleavage system
U876_RS13670	COG0404	The glycine cleavage system catalyzes the degradation of glycine
U876_RS13675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
U876_RS13680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
U876_RS13695	COG2814	Major facilitator Superfamily
U876_RS13700	COG0625	glutathione transferase activity
U876_RS13710	COG0483	inositol monophosphate 1-phosphatase activity
U876_RS13730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
U876_RS13745	COG1086	Polysaccharide biosynthesis protein
U876_RS13765	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
U876_RS13780	COG2089	acid synthase
U876_RS13850	COG0301	tRNA thio-modification
U876_RS13850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U876_RS13860	COG4953	penicillin-binding protein 1C
U876_RS13865	COG2373	Large extracellular alpha-helical protein
U876_RS13875	COG0628	permease
U876_RS13880	COG1538	Outer membrane efflux protein
U876_RS13900	COG0446	pyridine nucleotide-disulphide oxidoreductase
U876_RS13910	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
U876_RS13930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U876_RS13940	COG2431	L-lysine efflux transmembrane transporter activity
U876_RS13945	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
U876_RS13950	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
U876_RS13965	COG1393	Belongs to the ArsC family
U876_RS13975	COG4783	chaperone-mediated protein folding
U876_RS13980	COG0425	Belongs to the sulfur carrier protein TusA family
U876_RS14005	COG3842	ATPase activity
U876_RS14010	COG3833	ABC-type maltose transport systems, permease component
U876_RS14015	COG1175	transmembrane transport
U876_RS14025	COG3081	Nucleoid-associated protein
U876_RS14030	COG3082	Protein of unknown function (DUF1414)
U876_RS14035	COG3083	sulfuric ester hydrolase activity
U876_RS14040	COG4771	TonB-dependent receptor
U876_RS14045	COG1770	oligopeptidase
U876_RS14065	COG4574	serine-type endopeptidase inhibitor activity
U876_RS14070	COG3085	chromosome segregation
U876_RS14075	COG0583	DNA-binding transcription factor activity
U876_RS14080	COG1605	Chorismate mutase
U876_RS14080	COG0287	Prephenate dehydrogenase
U876_RS14085	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
U876_RS14090	COG0584	glycerophosphoryl diester phosphodiesterase
U876_RS14100	COG1349	DNA-binding transcription factor activity
U876_RS14105	COG2271	Major facilitator Superfamily
U876_RS14110	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
U876_RS14115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
U876_RS14120	COG0583	DNA-binding transcription factor activity
U876_RS14140	COG0656	L-ascorbic acid biosynthetic process
U876_RS14145	COG2814	Major facilitator Superfamily
U876_RS14155	COG1294	oxidase, subunit
U876_RS14165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U876_RS14175	COG2979	Protein of unknown function (DUF533)
U876_RS14195	COG2271	Major facilitator Superfamily
U876_RS14200	COG0583	DNA-binding transcription factor activity
U876_RS14210	COG2807	transmembrane transport
U876_RS14215	COG1187	pseudouridine synthase activity
U876_RS14240	COG1061	Type III restriction enzyme res subunit
U876_RS14250	COG2964	Protein conserved in bacteria
U876_RS14255	COG3681	Belongs to the UPF0597 family
U876_RS14265	COG0814	amino acid
U876_RS14285	COG1166	arginine decarboxylase activity
U876_RS14290	COG2195	Cleaves the N-terminal amino acid of tripeptides
U876_RS14320	COG0583	DNA-binding transcription factor activity
U876_RS14330	COG2759	Belongs to the formate--tetrahydrofolate ligase family
U876_RS14335	COG0840	transmembrane signaling receptor activity
U876_RS14340	COG0302	gtp cyclohydrolase
U876_RS14350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
U876_RS14355	COG2267	carboxylic ester hydrolase activity
U876_RS14360	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
U876_RS14375	COG0314	molybdopterin synthase activity
U876_RS14380	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
U876_RS14385	COG0315	cyclic pyranopterin monophosphate synthase activity
U876_RS14390	COG0521	Mo-molybdopterin cofactor biosynthetic process
U876_RS14395	COG3005	denitrification pathway
U876_RS14405	COG0348	domain, Protein
U876_RS14410	COG0437	4 iron, 4 sulfur cluster binding
U876_RS14415	COG0243	molybdopterin cofactor binding
U876_RS14425	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
U876_RS14425	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
U876_RS14430	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
U876_RS14435	COG3850	Histidine kinase
U876_RS14440	COG2197	response regulator
U876_RS14470	COG0121	glutamine amidotransferase
U876_RS14475	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
U876_RS14480	COG1960	acyl-CoA dehydrogenase activity
U876_RS14485	COG3437	response regulator, receiver
U876_RS14485	COG0784	Response regulator, receiver
U876_RS14500	COG0328	RNA-DNA hybrid ribonuclease activity
U876_RS14505	COG2226	methyltransferase
U876_RS14510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U876_RS14515	COG0741	lytic transglycosylase activity
U876_RS14515	COG1388	LysM domain
U876_RS14520	COG3021	interspecies interaction between organisms
U876_RS14530	COG1607	acyl-coa hydrolase
U876_RS14545	COG0741	lytic transglycosylase activity
U876_RS14555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
U876_RS14580	COG0729	surface antigen
U876_RS14590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
U876_RS14595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
U876_RS14605	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
U876_RS14615	COG4134	Bacterial extracellular solute-binding protein
U876_RS14625	COG4136	ATPase activity
U876_RS14630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
U876_RS14635	COG2951	lytic endotransglycosylase activity
U876_RS14640	COG1846	Transcriptional regulator
U876_RS14650	COG0033	Phosphoglucomutase
U876_RS14655	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
U876_RS14660	COG0596	Alpha beta hydrolase
U876_RS14675	COG0716	FMN binding
U876_RS14685	COG0735	belongs to the Fur family
U876_RS14690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
U876_RS14700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U876_RS14700	COG2190	(PTS) system
U876_RS14700	COG1263	PTS System
U876_RS14705	COG0363	glucosamine-6-phosphate deaminase activity
U876_RS14710	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
U876_RS14715	COG1940	carbohydrate kinase activity
U876_RS14715	COG1846	Transcriptional regulator
U876_RS14720	COG2194	sulfuric ester hydrolase activity
U876_RS14725	COG0217	transcriptional regulatory protein
U876_RS14730	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
U876_RS14735	COG1801	Protein of unknown function DUF72
U876_RS14740	COG4106	trans-aconitate 2-methyltransferase activity
U876_RS14745	COG0500	methyltransferase
U876_RS14765	COG0450	alkyl hydroperoxide reductase
U876_RS14770	COG0583	DNA-binding transcription factor activity
U876_RS14780	COG0791	NLP P60 protein
U876_RS14795	COG1309	transcriptional regulator
U876_RS14835	COG0534	Mate efflux family protein
U876_RS14855	COG2366	antibiotic biosynthetic process
U876_RS14860	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
U876_RS14860	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
U876_RS14860	COG0674	pyruvate-flavodoxin oxidoreductase activity
U876_RS14860	COG1013	pyruvate-flavodoxin oxidoreductase activity
U876_RS14870	COG3217	Mosc domain protein beta barrel domain protein
U876_RS14870	COG3217	Mosc domain protein beta barrel domain protein
U876_RS14870	COG0633	Ferredoxin
U876_RS14870	COG0633	Ferredoxin
U876_RS14880	COG0501	Belongs to the peptidase M48B family
U876_RS14885	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
U876_RS14890	COG1073	alpha beta
U876_RS14890	COG2226	methyltransferase
U876_RS14895	COG0156	8-amino-7-oxononanoate synthase activity
U876_RS14900	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
U876_RS14920	COG0017	Asparaginyl-tRNA synthetase
U876_RS14925	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
U876_RS14940	COG3069	C4-dicarboxylate transmembrane transporter activity
U876_RS14950	COG0583	DNA-binding transcription factor activity
U876_RS14955	COG1393	Belongs to the ArsC family
U876_RS14960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
U876_RS14965	COG1876	peptidase activity
U876_RS14970	COG3263	regulation of cellular component size
U876_RS14990	COG1280	lysine exporter protein (LysE YggA)
U876_RS15015	COG1957	nucleoside hydrolase
U876_RS15020	COG0564	pseudouridine synthase activity
U876_RS15030	COG1454	alcohol dehydrogenase
U876_RS15080	COG4964	Belongs to the GSP D family
U876_RS15110	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U876_RS15115	COG0702	epimerase
U876_RS15120	COG2914	Belongs to the UPF0125 (RnfH) family
U876_RS15125	COG2867	negative regulation of translational initiation
U876_RS15130	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
U876_RS15205	COG4397	Mu-like prophage major head subunit gpT
U876_RS15210	COG4388	Caudovirus prohead serine protease
U876_RS15230	COG4383	Mu-like prophage protein gp29
U876_RS15235	COG4373	Mu-like prophage FluMu protein gp28
U876_RS15245	COG0640	Transcriptional regulator
U876_RS15285	COG5566	PFAM Mor transcription activator
U876_RS15390	COG0583	DNA-binding transcription factor activity
U876_RS15395	COG2610	gluconate transmembrane transporter activity
U876_RS15400	COG3048	D-serine ammonia-lyase activity
U876_RS15405	COG0538	isocitrate dehydrogenase activity
U876_RS15410	COG2207	Transcriptional regulator
U876_RS15425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U876_RS15435	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
U876_RS15440	COG1263	PTS System
U876_RS15440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U876_RS15445	COG1609	Transcriptional regulator
U876_RS15460	COG0456	acetyltransferase
U876_RS15480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U876_RS15480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U876_RS15480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U876_RS15490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U876_RS15500	COG1187	pseudouridine synthase activity
U876_RS15510	COG0482	sulfurtransferase activity
U876_RS15515	COG2915	High frequency lysogenization protein hflD homolog
U876_RS15520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
U876_RS15525	COG2850	peptidyl-arginine hydroxylation
U876_RS15535	COG3153	acetyltransferase
U876_RS15545	COG0625	glutathione transferase activity
U876_RS15550	COG0259	pyridoxamine-phosphate oxidase activity
U876_RS15565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
U876_RS15565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
U876_RS15570	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
U876_RS15585	COG4235	cytochrome complex assembly
U876_RS15585	COG3088	subunit of a heme lyase
U876_RS15590	COG3088	subunit of a heme lyase
U876_RS15590	COG4235	cytochrome complex assembly
U876_RS15595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U876_RS15600	COG1138	Cytochrome C-type biogenesis protein
U876_RS15605	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
U876_RS15610	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
U876_RS15615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
U876_RS15620	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
U876_RS15635	COG0835	chemotaxis
U876_RS15645	COG1192	Involved in chromosome partitioning
U876_RS15650	COG1360	Flagellar Motor Protein
U876_RS15655	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
U876_RS15660	COG2201	protein-glutamate methylesterase activity
U876_RS15665	COG0784	Response regulator, receiver
U876_RS15665	COG2198	Histidine kinase
U876_RS15665	COG0643	Histidine kinase
U876_RS15670	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
U876_RS15695	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
U876_RS15705	COG1684	flagellar biosynthetic protein fliR
U876_RS15760	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
U876_RS15770	COG1677	Flagellar hook-basal body complex protein FliE
U876_RS15785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
U876_RS15795	COG1073	alpha beta
U876_RS15795	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
U876_RS15795	COG3064	Membrane
U876_RS15810	COG2274	protein secretion by the type I secretion system
U876_RS15820	COG2274	protein secretion by the type I secretion system
U876_RS15840	COG1737	Transcriptional regulator
U876_RS15845	COG0469	pyruvate kinase activity
U876_RS15855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U876_RS15860	COG1960	acyl-CoA dehydrogenase activity
U876_RS15870	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
U876_RS15880	COG0243	molybdopterin cofactor binding
U876_RS15885	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
U876_RS15890	COG0583	DNA-binding transcription factor activity
U876_RS15925	COG1454	alcohol dehydrogenase
U876_RS15925	COG1012	belongs to the aldehyde dehydrogenase family
U876_RS15935	COG1012	belongs to the aldehyde dehydrogenase family
U876_RS15935	COG1454	alcohol dehydrogenase
U876_RS15940	COG1882	Formate acetyltransferase
U876_RS15945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
U876_RS15955	COG4869	propanediol catabolic process
U876_RS16000	COG2731	YhcH YjgK YiaL family protein
U876_RS16005	COG2826	transposase and inactivated derivatives, IS30 family
U876_RS16010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
U876_RS16020	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
U876_RS16025	COG1737	Transcriptional regulator
U876_RS16030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
U876_RS16035	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
U876_RS16040	COG1349	DNA-binding transcription factor activity
U876_RS16045	COG0738	Major facilitator superfamily
U876_RS16055	COG1070	Carbohydrate kinase
U876_RS16075	COG4172	Belongs to the ABC transporter superfamily
U876_RS16080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U876_RS16090	COG0747	negative chemotaxis
U876_RS16100	COG1376	ErfK ybiS ycfS ynhG family protein
U876_RS16100	COG1388	LysM domain
U876_RS16115	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
U876_RS16120	COG0791	NLP P60 protein
U876_RS16125	COG2091	lysine biosynthetic process via aminoadipic acid
U876_RS16130	COG3118	belongs to the thioredoxin family
U876_RS16140	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
U876_RS16145	COG0788	formyltetrahydrofolate deformylase activity
U876_RS16155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
U876_RS16175	COG0366	Alpha amylase catalytic
U876_RS16180	COG1196	nuclear chromosome segregation
U876_RS16180	COG0741	lytic transglycosylase activity
U876_RS16180	COG0739	heme binding
U876_RS16185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
U876_RS16190	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
U876_RS16200	COG0673	inositol 2-dehydrogenase activity
U876_RS16220	COG1032	radical SAM domain protein
U876_RS16230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U876_RS16235	COG1566	PFAM secretion protein HlyD family protein
U876_RS16245	COG1752	Esterase of the alpha-beta hydrolase superfamily
U876_RS16250	COG0733	neurotransmitter:sodium symporter activity
U876_RS16280	COG0281	malic enzyme
U876_RS16290	COG0534	Mate efflux family protein
U876_RS16305	COG2233	PERMEase
U876_RS16310	COG0095	Lipoate-protein ligase
U876_RS16315	COG1115	amino acid carrier protein
U876_RS16320	COG0019	diaminopimelate decarboxylase activity
U876_RS16330	COG0678	peroxiredoxin activity
U876_RS16340	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
U876_RS16360	COG1131	(ABC) transporter
U876_RS16365	COG0545	Peptidyl-prolyl cis-trans isomerase
U876_RS16370	COG3142	Participates in the control of copper homeostasis
U876_RS16395	COG5002	protein histidine kinase activity
U876_RS16400	COG0745	RESPONSE REGULATOR receiver
U876_RS16405	COG0346	lactoylglutathione lyase activity
U876_RS16410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
U876_RS16415	COG1960	acyl-CoA dehydrogenase activity
U876_RS16420	COG3284	Transcriptional regulator
U876_RS16435	COG0697	spore germination
U876_RS16440	COG4565	transcriptional regulatory protein
U876_RS16445	COG3290	protein histidine kinase activity
U876_RS16450	COG0281	malic enzyme
U876_RS16460	COG1846	Transcriptional regulator
U876_RS16465	COG1566	PFAM secretion protein HlyD family protein
U876_RS16495	COG0602	queuosine metabolic process
U876_RS16500	COG1328	CTP reductase activity
U876_RS16510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
U876_RS16515	COG3115	cell septum assembly
U876_RS16520	COG1196	nuclear chromosome segregation
U876_RS16530	COG2860	membrane
U876_RS16540	COG3108	Peptidase M15
U876_RS16545	COG2989	Protein conserved in bacteria
U876_RS16560	COG0463	Glycosyl transferase, family 2
U876_RS16575	COG0366	Alpha amylase catalytic
U876_RS16610	COG3706	GGDEF domain
U876_RS16615	COG0037	tRNA processing
U876_RS16620	COG3590	peptidase
U876_RS16630	COG0488	(ABC) transporter
U876_RS16640	COG0531	amino acid
U876_RS16655	COG0814	amino acid
U876_RS16670	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
U876_RS16675	COG1982	Orn Lys Arg decarboxylase major
U876_RS16680	COG0531	amino acid
U876_RS16685	COG3710	Transcriptional regulator
U876_RS16690	COG0825	malonyl-CoA metabolic process
U876_RS16700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
U876_RS16705	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
U876_RS16710	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
U876_RS16715	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
U876_RS16720	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
U876_RS16735	COG0750	zinc metalloprotease
U876_RS16740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
U876_RS16745	COG0575	Belongs to the CDS family
U876_RS16750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
U876_RS16755	COG0233	cytoplasmic translational termination
U876_RS16760	COG0528	UMP kinase activity
U876_RS16765	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
U876_RS16770	COG0052	Belongs to the universal ribosomal protein uS2 family
U876_RS16775	COG0024	Methionine aminopeptidase
U876_RS16780	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
U876_RS16785	COG2171	N-acyltransferase activity
U876_RS16795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U876_RS16795	COG1263	PTS System
U876_RS16805	COG4580	involved in the transport of maltose and maltodextrins
U876_RS16815	COG0564	pseudouridine synthase activity
U876_RS16820	COG3098	single-species biofilm formation
U876_RS16845	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
U876_RS16855	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
U876_RS16855	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
U876_RS16870	COG1611	Belongs to the LOG family
U876_RS16875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
U876_RS16880	COG0473	3-isopropylmalate dehydrogenase activity
U876_RS16890	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
U876_RS16895	COG2363	Small membrane protein
U876_RS16905	COG0583	DNA-binding transcription factor activity
U876_RS16910	COG0840	transmembrane signaling receptor activity
U876_RS16915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
U876_RS16930	COG1477	protein flavinylation
U876_RS16935	COG2871	sodium ion transport
U876_RS16940	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
U876_RS16945	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
U876_RS16950	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
U876_RS16955	COG1805	sodium ion transport
U876_RS16960	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
U876_RS16965	COG0271	Belongs to the BolA IbaG family
U876_RS16970	COG2813	Specifically methylates the guanine in position
U876_RS16980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
U876_RS16990	COG2211	Major facilitator Superfamily
U876_RS16995	COG3248	Nucleoside-binding outer membrane protein
U876_RS17000	COG1666	GTP binding
U876_RS17005	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
U876_RS17010	COG0693	protein deglycase activity
U876_RS17055	COG2771	luxR family
U876_RS17065	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
U876_RS17065	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
U876_RS17070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
U876_RS17080	COG1151	hydroxylamine reductase activity
U876_RS17085	COG0783	Belongs to the Dps family
U876_RS17110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
U876_RS17125	COG4221	oxidoreductase activity
U876_RS17135	COG0415	Belongs to the DNA photolyase family
U876_RS17140	COG0789	Transcriptional regulator
U876_RS17145	COG3272	Protein of unknown function (DUF1722)
U876_RS17175	COG1605	Chorismate mutase
U876_RS17175	COG0077	Prephenate dehydratase
U876_RS17310	COG2003	Belongs to the UPF0758 family
U876_RS17380	COG2826	transposase and inactivated derivatives, IS30 family
U876_RS17390	COG0582	viral genome integration into host DNA
U876_RS17400	COG5377	YqaJ viral recombinase family
U876_RS17440	COG2003	Belongs to the UPF0758 family
U876_RS17450	COG0602	queuosine metabolic process
U876_RS17455	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
U876_RS17475	COG0720	synthase
U876_RS17510	COG0514	ATP-dependent DNA helicase (RecQ)
U876_RS17515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
U876_RS17540	COG4771	TonB-dependent receptor
U876_RS17585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U876_RS17590	COG1120	ATPase activity
U876_RS17600	COG2226	methyltransferase
U876_RS17605	COG3328	transposase activity
U876_RS17625	COG2133	pyrroloquinoline quinone binding
U876_RS17635	COG0840	transmembrane signaling receptor activity
U876_RS17645	COG0300	oxidoreductase activity
U876_RS17665	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
U876_RS17680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
U876_RS17685	COG0826	peptidase U32
U876_RS17690	COG1280	lysine exporter protein (LysE YggA)
U876_RS17700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
U876_RS17705	COG0840	transmembrane signaling receptor activity
U876_RS17720	COG0643	Histidine kinase
U876_RS17720	COG2198	Histidine kinase
U876_RS17730	COG0835	chemotaxis
U876_RS17735	COG0840	transmembrane signaling receptor activity
U876_RS17745	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
U876_RS17750	COG2201	protein-glutamate methylesterase activity
U876_RS17755	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
U876_RS17785	COG2200	EAL domain
U876_RS17785	COG2203	Gaf domain
U876_RS17785	COG2199	diguanylate cyclase activity
U876_RS17790	COG0826	peptidase U32
U876_RS17795	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
U876_RS17800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
U876_RS17805	COG0305	Participates in initiation and elongation during chromosome replication
U876_RS17815	COG2200	EAL domain
U876_RS17820	COG0737	Belongs to the 5'-nucleotidase family
U876_RS17840	COG2204	response regulator
U876_RS17845	COG0545	Peptidyl-prolyl cis-trans isomerase
U876_RS17860	COG1047	Peptidyl-prolyl cis-trans
U876_RS17865	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
U876_RS17875	COG0784	Response regulator, receiver
U876_RS17875	COG0835	chemotaxis
U876_RS17880	COG0429	hydrolase of the alpha beta-hydrolase fold
U876_RS17885	COG3706	GGDEF domain
U876_RS17885	COG4251	negative regulation of phosphorylation
U876_RS17885	COG2203	Gaf domain
U876_RS17885	COG5001	Diguanylate cyclase
U876_RS17890	COG3089	Belongs to the UPF0270 family
U876_RS17900	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
U876_RS17905	COG0463	Glycosyl transferase, family 2
U876_RS17910	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
U876_RS17910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
U876_RS17915	COG0726	polysaccharide deacetylase
U876_RS17920	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
U876_RS17925	COG2076	Multidrug Resistance protein
U876_RS17930	COG2076	Multidrug Resistance protein
U876_RS17935	COG3954	Phosphoribulokinase
U876_RS17950	COG1765	OsmC-like protein
U876_RS17960	COG2226	methyltransferase
U876_RS17965	COG3397	chitin binding
U876_RS17980	COG2205	protein histidine kinase activity
U876_RS17980	COG2202	Pas domain
U876_RS17990	COG3655	Transcriptional regulator
U876_RS17995	COG2814	Major facilitator Superfamily
U876_RS18000	COG4771	TonB-dependent receptor
U876_RS18020	COG0748	coenzyme F420 binding
U876_RS18025	COG3721	Heme iron utilization protein
U876_RS18035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U876_RS18060	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
U876_RS18065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
U876_RS18070	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
U876_RS18090	COG0741	lytic transglycosylase activity
U876_RS18095	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
U876_RS18190	COG0616	signal peptide processing
U876_RS18205	COG1802	Transcriptional regulator
U876_RS18205	COG4626	Terminase
U876_RS18250	COG0464	growth
U876_RS18380	COG0582	viral genome integration into host DNA
U876_RS18385	COG0488	(ABC) transporter
U876_RS18395	COG2252	PERMEase
U876_RS18400	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
U876_RS18405	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
U876_RS18415	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
U876_RS18425	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
U876_RS18430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
U876_RS18435	COG2967	ApaG domain
U876_RS18440	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
U876_RS18450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
U876_RS18455	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
U876_RS18470	COG0318	PFAM AMP-dependent synthetase and ligase
U876_RS18475	COG3314	Sporulation integral membrane protein YlbJ
U876_RS18480	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
U876_RS18485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
U876_RS18495	COG0142	geranyltranstransferase activity
U876_RS18500	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
U876_RS18505	COG0330	HflC and HflK could
U876_RS18510	COG0330	HflC and HflK could
U876_RS18515	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
U876_RS18520	COG1923	regulation of RNA biosynthetic process
U876_RS18525	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
U876_RS18530	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
U876_RS18540	COG0802	atpase or kinase
U876_RS18545	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
U876_RS18545	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
U876_RS18570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
U876_RS18575	COG2011	ABC-type metal ion transport system permease component
U876_RS18580	COG1464	Belongs to the NlpA lipoprotein family
U876_RS18590	COG0840	transmembrane signaling receptor activity
U876_RS18615	COG5002	protein histidine kinase activity
U876_RS18615	COG0784	Response regulator, receiver
U876_RS18615	COG2198	Histidine kinase
U876_RS18635	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
U876_RS18650	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
U876_RS18655	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
U876_RS18665	COG2716	regulation of RNA biosynthetic process
U876_RS18670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
U876_RS18675	COG3013	Belongs to the UPF0304 family
U876_RS18685	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
U876_RS18690	COG0280	phosphate acetyltransferase
U876_RS18690	COG0857	belongs to the CobB CobQ family
U876_RS18700	COG0028	Belongs to the TPP enzyme family
U876_RS18710	COG0671	phosphoesterase, PA-phosphatase related
U876_RS18720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
U876_RS18725	COG0473	3-isopropylmalate dehydrogenase activity
U876_RS18730	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
U876_RS18735	COG0066	3-isopropylmalate dehydratase activity
U876_RS18755	COG1178	ABC-type Fe3 transport system permease component
U876_RS18760	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
U876_RS18765	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
U876_RS18775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
U876_RS18805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
U876_RS18810	COG0564	pseudouridine synthase activity
U876_RS18820	COG3300	MHYT domain
U876_RS18820	COG5001	Diguanylate cyclase
U876_RS18830	COG0459	protein refolding
U876_RS18835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
U876_RS18840	COG0534	Mate efflux family protein
U876_RS18845	COG3030	protein affecting phage T7 exclusion by the F plasmid
U876_RS18850	COG1027	Aspartate ammonia-lyase
U876_RS18855	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
U876_RS18865	COG0477	Major facilitator Superfamily
U876_RS18885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U876_RS18895	COG0673	inositol 2-dehydrogenase activity
U876_RS18905	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
U876_RS18910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
U876_RS18915	COG3036	rescue of stalled ribosome
U876_RS18920	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
U876_RS18930	COG0138	bifunctional purine biosynthesis protein purh
U876_RS18935	COG0151	Belongs to the GarS family
U876_RS18965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
U876_RS18970	COG0358	DNA primase activity
U876_RS18975	COG1610	YqeY-like protein
U876_RS18980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
U876_RS18995	COG1238	metal cluster binding
U876_RS19000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
U876_RS19005	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
U876_RS19010	COG0585	pseudouridine synthase activity
U876_RS19020	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
U876_RS19025	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
U876_RS19030	COG0148	phosphopyruvate hydratase activity
U876_RS19035	COG0504	CTP synthase activity
U876_RS19040	COG3956	TIGRFAM MazG family protein
U876_RS19045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
U876_RS19050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
U876_RS19060	COG4807	Protein conserved in bacteria
U876_RS19065	COG3023	N-Acetylmuramoyl-L-alanine amidase
U876_RS19070	COG1349	DNA-binding transcription factor activity
U876_RS19080	COG2222	sugar isomerase
U876_RS19085	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U876_RS19095	COG3716	PTS system mannose fructose sorbose family IID component
U876_RS19100	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
U876_RS19105	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
U876_RS19120	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
U876_RS19125	COG1381	Involved in DNA repair and RecF pathway recombination
U876_RS19135	COG0571	ribonuclease III activity
U876_RS19140	COG0681	Belongs to the peptidase S26 family
U876_RS19145	COG0481	GTPase activity
U876_RS19160	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
U876_RS19165	COG1595	DNA-templated transcription, initiation
U876_RS19170	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
U876_RS19180	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
U876_RS19185	COG0354	folic acid binding
U876_RS19220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
U876_RS19225	COG0191	fructose-bisphosphate aldolase activity
U876_RS19230	COG0126	phosphoglycerate kinase activity
U876_RS19235	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
U876_RS19240	COG1940	carbohydrate kinase activity
U876_RS19245	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
U876_RS19260	COG4991	sh3 domain protein
U876_RS19265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
U876_RS19280	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
U876_RS19300	COG1505	serine-type exopeptidase activity
U876_RS19305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
U876_RS19310	COG0765	amino acid transport
U876_RS19315	COG0765	amino acid transport
U876_RS19320	COG1126	abc transporter atp-binding protein
U876_RS19325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U876_RS19330	COG1136	(ABC) transporter
U876_RS19330	COG0577	efflux transmembrane transporter activity
U876_RS19335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U876_RS19340	COG0745	RESPONSE REGULATOR receiver
U876_RS19345	COG2205	protein histidine kinase activity
U876_RS19385	COG2070	2-Nitropropane dioxygenase
U876_RS19410	COG1858	cytochrome C peroxidase
U876_RS19415	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
U876_RS19435	COG0513	Belongs to the DEAD box helicase family
U876_RS19450	COG0154	amidase activity
U876_RS19455	COG2957	Belongs to the agmatine deiminase family
U876_RS19470	COG1902	pentaerythritol trinitrate reductase activity
U876_RS19515	COG0714	Associated with various cellular activities
U876_RS19525	COG0456	acetyltransferase
U876_RS19535	COG1022	Amp-dependent synthetase and ligase
U876_RS19545	COG2918	glutathione biosynthetic process
U876_RS19550	COG0612	Peptidase, M16
U876_RS19555	COG1238	metal cluster binding
U876_RS19575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
U876_RS19580	COG0359	binds to the 23S rRNA
U876_RS19585	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
U876_RS19590	COG0360	Binds together with S18 to 16S ribosomal RNA
U876_RS19595	COG1914	H( )-stimulated, divalent metal cation uptake system
U876_RS19615	COG2153	protein acetylation
U876_RS19625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
U876_RS19630	COG0557	exoribonuclease II activity
U876_RS19635	COG3706	GGDEF domain
U876_RS19640	COG1854	S-ribosylhomocysteine lyase activity
U876_RS19655	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
U876_RS19655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
U876_RS19710	COG4970	Tfp pilus assembly protein FimT
U876_RS19715	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
U876_RS19720	COG1047	Peptidyl-prolyl cis-trans
U876_RS19725	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
U876_RS19730	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
U876_RS19735	COG0196	riboflavin kinase activity
U876_RS19740	COG0728	peptidoglycan biosynthetic process
U876_RS19745	COG0268	Binds directly to 16S ribosomal RNA
U876_RS19750	COG0640	Transcriptional regulator
U876_RS19755	COG0583	DNA-binding transcription factor activity
U876_RS19765	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
U876_RS19770	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
U876_RS19775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
U876_RS19785	COG1051	belongs to the nudix hydrolase family
U876_RS19790	COG3066	DNA modification
U876_RS19800	COG0335	large ribosomal subunit rRNA binding
U876_RS19805	COG0336	Belongs to the RNA methyltransferase TrmD family
U876_RS19810	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
U876_RS19815	COG0228	four-way junction DNA binding
U876_RS19820	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
U876_RS19825	COG4137	Cytochrome C assembly protein
U876_RS19830	COG4536	flavin adenine dinucleotide binding
U876_RS19840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
U876_RS19840	COG1017	nitric oxide dioxygenase activity
U876_RS19845	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
U876_RS19850	COG0039	L-malate dehydrogenase activity
U876_RS19855	COG4160	amino acid transport
U876_RS19860	COG4215	(ABC) transporter
U876_RS19865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U876_RS19870	COG1126	abc transporter atp-binding protein
U876_RS19875	COG1438	arginine binding
U876_RS19880	COG2837	iron assimilation
U876_RS19885	COG3842	ATPase activity
U876_RS19895	COG1840	ABC-type Fe3 transport system, periplasmic component
U876_RS19900	COG0347	Belongs to the P(II) protein family
U876_RS19915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
U876_RS19920	COG0583	DNA-binding transcription factor activity
U876_RS19935	COG1929	Belongs to the glycerate kinase type-1 family
U876_RS19940	COG2610	gluconate transmembrane transporter activity
U876_RS19945	COG3835	regulator
U876_RS19950	COG3112	Uncharacterised protein family (UPF0231)
U876_RS19965	COG0840	transmembrane signaling receptor activity
U876_RS19985	COG0513	Belongs to the DEAD box helicase family
U876_RS20025	COG1448	Aminotransferase
U876_RS20040	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
U876_RS20045	COG1328	CTP reductase activity
U876_RS20065	COG4946	Tricorn protease homolog
U876_RS20065	COG0793	Belongs to the peptidase S41A family
U876_RS20095	COG0840	transmembrane signaling receptor activity
U876_RS20100	COG3397	chitin binding
U876_RS20105	COG0583	DNA-binding transcription factor activity
U876_RS20110	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
U876_RS20115	COG4208	sulfate ABC transporter
U876_RS20120	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
U876_RS20130	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
U876_RS20135	COG3174	membrane
U876_RS20140	COG0110	maltose O-acetyltransferase activity
U876_RS20165	COG0165	Argininosuccinate lyase
U876_RS20170	COG0137	argininosuccinate synthase activity
U876_RS20180	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
U876_RS20185	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
U876_RS20195	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
U876_RS20205	COG0527	aspartate kinase activity
U876_RS20205	COG0460	homoserine dehydrogenase
U876_RS20210	COG0626	cystathionine gamma-synthase activity
U876_RS20220	COG3708	Transcriptional regulator
U876_RS20220	COG2207	Transcriptional regulator
U876_RS20225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U876_RS20230	COG0814	amino acid
U876_RS20235	COG1218	3'(2'),5'-bisphosphate nucleotidase
U876_RS20240	COG0494	nUDIX hydrolase
U876_RS20245	COG1011	Hydrolase
U876_RS20250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
U876_RS20265	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
U876_RS20275	COG3156	type II secretion system protein K
U876_RS20280	COG4795	General secretion pathway protein
U876_RS20285	COG2165	general secretion pathway protein
U876_RS20295	COG2165	general secretion pathway protein
U876_RS20300	COG1459	type II secretion system
U876_RS20305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
U876_RS20315	COG3031	protein transport across the cell outer membrane
U876_RS20325	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
U876_RS20330	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
U876_RS20350	COG0456	acetyltransferase
U876_RS20355	COG3133	Outer membrane lipoprotein
U876_RS20370	COG2771	luxR family
U876_RS20375	COG3916	Acyl-homoserine-lactone synthase
U876_RS20385	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
U876_RS20390	COG1309	transcriptional regulator
U876_RS20400	COG2213	PTS system mannitol-specific
U876_RS20400	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
U876_RS20405	COG0246	Mannitol dehydrogenase
U876_RS20410	COG3722	fumarate hydratase activity
U876_RS20415	COG3263	regulation of cellular component size
U876_RS20440	COG1671	Belongs to the UPF0178 family
U876_RS20455	COG1988	membrane-bound metal-dependent
U876_RS20460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
U876_RS20465	COG0513	Belongs to the DEAD box helicase family
U876_RS20490	COG1575	Belongs to the MenA family. Type 1 subfamily
U876_RS20495	COG1169	isochorismate synthase
U876_RS20500	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
U876_RS20505	COG0596	Alpha beta hydrolase
U876_RS20510	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
U876_RS20515	COG1441	menaquinone biosynthetic process
U876_RS20520	COG0318	PFAM AMP-dependent synthetase and ligase
U876_RS20535	COG3539	Fimbrial protein
U876_RS20540	COG3121	Chaperone
U876_RS20545	COG3188	usher protein
U876_RS20555	COG3539	Fimbrial protein
U876_RS20565	COG3291	Pkd domain containing protein
U876_RS20570	COG2949	membrane
U876_RS20575	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
U876_RS20585	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
U876_RS20590	COG5380	lipid catabolic process
U876_RS20605	COG4533	DNA binding
U876_RS20610	COG2873	o-acetylhomoserine
U876_RS20620	COG1979	alcohol dehydrogenase
U876_RS20640	COG4221	oxidoreductase activity
U876_RS20660	COG1285	pathogenesis
U876_RS20680	COG1368	sulfuric ester hydrolase activity
U876_RS20685	COG1522	sequence-specific DNA binding
U876_RS20695	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
U876_RS20700	COG1418	mRNA catabolic process
U876_RS20705	COG1058	Belongs to the CinA family
U876_RS20705	COG1546	Belongs to the CinA family
U876_RS20720	COG1129	ABC transporter
U876_RS20720	COG0842	Transport permease protein
U876_RS20735	COG0561	phosphatase activity
U876_RS20740	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
U876_RS20760	COG1011	Hydrolase
U876_RS20775	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
U876_RS20780	COG0019	diaminopimelate decarboxylase activity
U876_RS20785	COG1965	Belongs to the frataxin family
U876_RS20790	COG0400	carboxylic ester hydrolase activity
U876_RS20795	COG3072	Adenylate cyclase
U876_RS20800	COG0181	hydroxymethylbilane synthase activity
U876_RS20810	COG2959	enzyme of heme biosynthesis
U876_RS20825	COG1494	fructose-1,6-bisphosphatase
U876_RS20865	COG1733	regulation of RNA biosynthetic process
U876_RS20885	COG3932	Exopolysaccharide synthesis, ExoD
U876_RS20890	COG0814	amino acid
U876_RS20895	COG3706	GGDEF domain
U876_RS20910	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
U876_RS20920	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
U876_RS20925	COG2022	thiamine diphosphate biosynthetic process
U876_RS20935	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
U876_RS20940	COG0352	thiamine-phosphate diphosphorylase activity
U876_RS20945	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
U876_RS20965	COG0745	RESPONSE REGULATOR receiver
U876_RS20970	COG0642	Histidine kinase
U876_RS20980	COG0189	ligase activity
U876_RS21020	COG3171	Protein conserved in bacteria
U876_RS21035	COG3188	usher protein
U876_RS21085	COG1639	'signal transduction protein
U876_RS21095	COG2321	neutral zinc metallopeptidase
U876_RS21100	COG3700	Belongs to the class B bacterial acid phosphatase family
U876_RS21120	COG1366	Belongs to the anti-sigma-factor antagonist family
U876_RS21125	COG2172	sigma factor antagonist activity
U876_RS21130	COG0784	Response regulator, receiver
U876_RS21130	COG5002	protein histidine kinase activity
U876_RS21130	COG2205	protein histidine kinase activity
U876_RS21135	COG3437	response regulator, receiver
U876_RS21145	COG0477	Major facilitator Superfamily
U876_RS21160	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
U876_RS21165	COG1263	PTS System
U876_RS21165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U876_RS21185	COG0312	modulator of DNA gyrase
U876_RS21190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
U876_RS21200	COG3164	Protein of unknown function
U876_RS21205	COG1530	ribonuclease E activity
U876_RS21210	COG0424	maF-like protein
U876_RS21215	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
U876_RS21220	COG1792	Involved in formation and maintenance of cell shape
U876_RS21225	COG1077	Cell shape determining protein MreB Mrl
U876_RS21250	COG4968	Prepilin-type N-terminal cleavage methylation domain
U876_RS21255	COG4969	Belongs to the N-Me-Phe pilin family
U876_RS21260	COG2165	general secretion pathway protein
U876_RS21270	COG1459	type II secretion system
U876_RS21275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
U876_RS21285	COG2842	Transposition protein
U876_RS21320	COG2199	diguanylate cyclase activity
U876_RS21320	COG2200	EAL domain
U876_RS21325	COG2200	EAL domain
U876_RS21330	COG0387	Pfam Sodium calcium exchanger
U876_RS21335	COG2986	histidine ammonia-lyase
U876_RS21340	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
U876_RS21345	COG0010	Belongs to the arginase family
U876_RS21350	COG1228	amidohydrolase
U876_RS21355	COG2188	Transcriptional regulator
U876_RS21360	COG0288	reversible hydration of carbon dioxide
U876_RS21370	COG2177	Part of the ABC transporter FtsEX involved in
U876_RS21375	COG2884	Cell division ATP-binding protein ftsE
U876_RS21380	COG0552	protein localization to endoplasmic reticulum
U876_RS21385	COG0742	ribosomal rna small subunit methyltransferase
U876_RS21410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
U876_RS21415	COG0741	lytic transglycosylase activity
U876_RS21425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
U876_RS21435	COG2095	MarC family integral membrane protein
U876_RS21445	COG1301	dicarboxylic acid transport
U876_RS21470	COG3714	YhhN family
U876_RS21485	COG1770	oligopeptidase
U876_RS21500	COG4221	oxidoreductase activity
U876_RS21505	COG0583	DNA-binding transcription factor activity
U876_RS21510	COG2249	NAD(P)H dehydrogenase (quinone) activity
U876_RS21555	COG0203	ribosomal protein L17
U876_RS21560	COG0202	RNA polymerase activity
U876_RS21565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
U876_RS21570	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
U876_RS21575	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
U876_RS21580	COG0201	protein transport
U876_RS21585	COG0200	Binds to the 23S rRNA
U876_RS21590	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
U876_RS21595	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
U876_RS21600	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
U876_RS21605	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
U876_RS21610	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
U876_RS21615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
U876_RS21620	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
U876_RS21625	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
U876_RS21630	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
U876_RS21635	COG0255	Belongs to the universal ribosomal protein uL29 family
U876_RS21640	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
U876_RS21645	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
U876_RS21650	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
U876_RS21655	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
U876_RS21660	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
U876_RS21665	COG0089	rRNA binding
U876_RS21670	COG0088	Forms part of the polypeptide exit tunnel
U876_RS21675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
U876_RS21680	COG0051	transcription antitermination factor activity, RNA binding
U876_RS21700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
U876_RS21705	COG2183	response to ionizing radiation
U876_RS21725	COG0596	Alpha beta hydrolase
U876_RS21730	COG1040	competence protein
U876_RS21735	COG0316	Belongs to the HesB IscA family
U876_RS21735	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
U876_RS21740	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
U876_RS21745	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
U876_RS21750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U876_RS21755	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
U876_RS21760	COG4942	peptidase
U876_RS21770	COG1609	Transcriptional regulator
U876_RS21775	COG0800	Aldolase
U876_RS21780	COG0129	dihydroxy-acid dehydratase activity
U876_RS21785	COG3265	gluconokinase activity
U876_RS21790	COG2610	gluconate transmembrane transporter activity
U876_RS21795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
U876_RS21800	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
U876_RS21810	COG0456	acetyltransferase
U876_RS21820	COG1490	D-aminoacyl-tRNA deacylase activity
U876_RS21825	COG1295	ribonuclease BN
U876_RS21830	COG1217	gtp-binding protein TYPA
U876_RS21835	COG0174	glutamine synthetase
U876_RS21845	COG3852	Histidine kinase
U876_RS21850	COG2204	response regulator
U876_RS21855	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
U876_RS21860	COG0635	Involved in the biosynthesis of porphyrin-containing compound
U876_RS21870	COG3078	GTPase activator activity
U876_RS21885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
U876_RS21895	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
U876_RS21900	COG0408	coproporphyrinogen oxidase activity
U876_RS21905	COG0009	L-threonylcarbamoyladenylate synthase
U876_RS21915	COG0551	DNA topoisomerase type I activity
U876_RS21920	COG2922	Belongs to the Smg family
U876_RS21925	COG0758	DNA mediated transformation
U876_RS21935	COG0242	peptide deformylase activity
U876_RS21940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
U876_RS21945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
U876_RS21945	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
U876_RS21950	COG0569	domain protein
U876_RS21955	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
U876_RS21960	COG1322	Protein conserved in bacteria
U876_RS21980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U876_RS21985	COG0686	Belongs to the AlaDH PNT family
U876_RS21990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
U876_RS21990	COG0519	Catalyzes the synthesis of GMP from XMP
U876_RS22000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
U876_RS22005	COG1396	sequence-specific DNA binding
U876_RS22010	COG1012	belongs to the aldehyde dehydrogenase family
U876_RS22020	COG2962	Rard protein
U876_RS22030	COG1280	lysine exporter protein (LysE YggA)
U876_RS22040	COG2391	methyltransferase activity
U876_RS22045	COG1280	lysine exporter protein (LysE YggA)
U876_RS22090	COG0583	DNA-binding transcription factor activity
U876_RS22095	COG1943	Transposase
U876_RS22100	COG0210	DNA helicase
U876_RS22105	COG1744	ABC transporter substrate-binding protein PnrA-like
U876_RS22110	COG3845	ABC transporter
U876_RS22115	COG4603	Belongs to the binding-protein-dependent transport system permease family
U876_RS22120	COG1079	Belongs to the binding-protein-dependent transport system permease family
U876_RS22125	COG0583	DNA-binding transcription factor activity
U876_RS22145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
U876_RS22150	COG0385	Bile acid
U876_RS22155	COG0531	amino acid
U876_RS22160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U876_RS22165	COG0531	amino acid
U876_RS22170	COG2731	YhcH YjgK YiaL family protein
U876_RS22175	COG3250	beta-galactosidase activity
U876_RS22180	COG1609	Transcriptional regulator
U876_RS22215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
U876_RS22220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
U876_RS22220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
U876_RS22225	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
U876_RS22230	COG3074	FtsZ-dependent cytokinesis
U876_RS22240	COG1045	serine acetyltransferase
U876_RS22250	COG0745	RESPONSE REGULATOR receiver
U876_RS22255	COG2205	protein histidine kinase activity
U876_RS22260	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
U876_RS22265	COG0534	Mate efflux family protein
U876_RS22280	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
U876_RS22285	COG2937	Belongs to the GPAT DAPAT family
U876_RS22290	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
U876_RS22295	COG3161	chorismate lyase activity
U876_RS22300	COG1580	Controls the rotational direction of flagella during chemotaxis
U876_RS22310	COG0604	alcohol dehydrogenase
U876_RS22315	COG1609	Transcriptional regulator
U876_RS22335	COG1519	Transferase
U876_RS22340	COG0859	PFAM glycosyl transferase family 9
U876_RS22345	COG0463	Glycosyl transferase, family 2
U876_RS22350	COG0859	PFAM glycosyl transferase family 9
U876_RS22355	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
U876_RS22360	COG2990	Protein conserved in bacteria
U876_RS22365	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
U876_RS22375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
U876_RS22380	COG2003	Belongs to the UPF0758 family
U876_RS22385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
U876_RS22390	COG0756	dUTP diphosphatase activity
U876_RS22395	COG1309	transcriptional regulator
U876_RS22400	COG0668	transmembrane transport
U876_RS22410	COG0166	Belongs to the GPI family
U876_RS22415	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
U876_RS22420	COG0583	DNA-binding transcription factor activity
U876_RS22460	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
U876_RS22465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
U876_RS22470	COG1739	Uncharacterized protein family UPF0029
U876_RS22475	COG0006	proline dipeptidase activity
U876_RS22480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
U876_RS22485	COG1250	3-hydroxyacyl-CoA dehydrogenase
U876_RS22485	COG1024	Enoyl-CoA hydratase
U876_RS22490	COG0183	Belongs to the thiolase family
U876_RS22515	COG0425	Belongs to the sulfur carrier protein TusA family
U876_RS22520	COG0251	oxidation-reduction process
U876_RS22525	COG2885	chlorophyll binding
U876_RS22530	COG1335	isochorismatase
U876_RS22535	COG2818	Glycosylase
U876_RS22540	COG0752	glycyl-tRNA synthetase alpha subunit
U876_RS22545	COG0751	glycine-tRNA ligase activity
U876_RS22560	COG0529	Catalyzes the synthesis of activated sulfate
U876_RS22560	COG2046	Belongs to the sulfate adenylyltransferase family
U876_RS22580	COG0814	amino acid
U876_RS22585	COG0348	domain, Protein
U876_RS22595	COG0446	pyridine nucleotide-disulphide oxidoreductase
U876_RS22600	COG0426	domain, Protein
U876_RS22600	COG1773	rubredoxin
U876_RS22605	COG3604	Transcriptional regulator
U876_RS22610	COG2188	Transcriptional regulator
U876_RS22625	COG1609	Transcriptional regulator
U876_RS22665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U876_RS22690	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
U876_RS22705	COG3118	belongs to the thioredoxin family
U876_RS22710	COG0513	Belongs to the DEAD box helicase family
U876_RS22715	COG0248	Ppx GppA phosphatase
U876_RS22730	COG0742	ribosomal rna small subunit methyltransferase
U876_RS22750	COG0084	hydrolase, TatD family'
U876_RS22755	COG0805	protein transport
U876_RS22760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
U876_RS22770	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
U876_RS22775	COG3165	ubiquinone biosynthetic process from chorismate
U876_RS22785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
U876_RS22790	COG0402	S-adenosylhomocysteine deaminase activity
U876_RS22830	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
U876_RS22835	COG0848	biopolymer transport protein
U876_RS22840	COG0811	peptide transport
U876_RS22845	COG0811	peptide transport
U876_RS22855	COG2771	luxR family
U876_RS22860	COG5433	transposase activity
U876_RS22875	COG4771	TonB-dependent receptor
U876_RS22880	COG4133	protoheme IX ABC transporter activity
U876_RS22885	COG4107	phosphonate C-P lyase system protein PhnK
U876_RS22890	COG3627	carbon phosphorus lyase activity
U876_RS22895	COG3626	phosphonate metabolism
U876_RS22915	COG1120	ATPase activity
U876_RS22920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U876_RS22925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
U876_RS22935	COG0583	DNA-binding transcription factor activity
U876_RS23050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
U876_RS23095	COG1192	Involved in chromosome partitioning
U876_RS23150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
U876_RS23380	COG1121	(ABC) transporter
U876_RS23405	COG3550	peptidyl-serine autophosphorylation
U876_RS23410	COG1396	sequence-specific DNA binding
U876_RS23495	COG5433	transposase activity
U876_RS23510	COG4771	TonB-dependent receptor
U876_RS23515	COG4133	protoheme IX ABC transporter activity
U876_RS23520	COG4107	phosphonate C-P lyase system protein PhnK
U876_RS23525	COG3627	carbon phosphorus lyase activity
U876_RS23530	COG3626	phosphonate metabolism
U876_RS23550	COG1120	ATPase activity
U876_RS23555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U876_RS23560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
U876_RS23570	COG0583	DNA-binding transcription factor activity
U876_RS23605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
U876_RS23610	COG1349	DNA-binding transcription factor activity
U876_RS23615	COG0745	RESPONSE REGULATOR receiver
U876_RS23620	COG2205	protein histidine kinase activity
U876_RS23630	COG4452	Inner membrane protein CreD
U876_RS23635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
U876_RS23640	COG0355	proton-transporting ATP synthase activity, rotational mechanism
U876_RS23645	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
U876_RS23650	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
U876_RS23655	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
U876_RS23660	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
U876_RS23665	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
U876_RS23675	COG0356	it plays a direct role in the translocation of protons across the membrane
U876_RS23685	COG1475	DNA binding
U876_RS23690	COG1192	Involved in chromosome partitioning
U876_RS23695	COG0357	Ribosomal RNA small subunit methyltransferase G
U876_RS23700	COG0445	tRNA wobble uridine modification
U876_RS23705	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
U876_RS23710	COG4774	siderophore transport
U876_RS23715	COG4615	Cyclic peptide transporter
U876_RS23720	COG1120	ATPase activity
U876_RS23735	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
U876_RS23740	COG0706	membrane insertase activity
U876_RS23745	COG0594	ribonuclease P activity
U876_RS23750	COG0230	Belongs to the bacterial ribosomal protein bL34 family
U876_RS23755	COG1126	abc transporter atp-binding protein
U876_RS23815	COG0582	viral genome integration into host DNA
U876_RS23845	COG1116	anion transmembrane transporter activity