locus-tag	class	description
L6424_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L6424_RS00010	COG0592	DNA-directed DNA polymerase activity
L6424_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L6424_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
L6424_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
L6424_RS00045	COG3977	Valine--pyruvate aminotransferase
L6424_RS00060	COG2814	Major facilitator Superfamily
L6424_RS00065	COG0745	RESPONSE REGULATOR receiver
L6424_RS00070	COG2205	protein histidine kinase activity
L6424_RS00090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L6424_RS00095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6424_RS00095	COG4191	Histidine kinase
L6424_RS00100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6424_RS00105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6424_RS00110	COG1309	transcriptional regulator
L6424_RS00140	COG0469	pyruvate kinase activity
L6424_RS00145	COG2271	Major facilitator Superfamily
L6424_RS00175	COG0561	phosphatase activity
L6424_RS00180	COG2267	carboxylic ester hydrolase activity
L6424_RS00185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L6424_RS00190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L6424_RS00195	COG1758	RNA polymerase activity
L6424_RS00205	COG0859	PFAM glycosyl transferase family 9
L6424_RS00210	COG3642	lipopolysaccharide core region biosynthetic process
L6424_RS00250	COG0589	response to stress
L6424_RS00255	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L6424_RS00265	COG1528	Iron-storage protein
L6424_RS00270	COG2081	HI0933 family
L6424_RS00275	COG2223	nitrite transmembrane transporter activity
L6424_RS00295	COG3188	usher protein
L6424_RS00320	COG2205	protein histidine kinase activity
L6424_RS00320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6424_RS00330	COG3275	phosphorelay sensor kinase activity
L6424_RS00335	COG3279	Response regulator of the LytR AlgR family
L6424_RS00340	COG2223	nitrite transmembrane transporter activity
L6424_RS00345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L6424_RS00350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L6424_RS00365	COG0583	DNA-binding transcription factor activity
L6424_RS00370	COG4206	TonB-dependent receptor
L6424_RS00375	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L6424_RS00410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L6424_RS00415	COG2166	iron-sulfur cluster assembly
L6424_RS00420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L6424_RS00425	COG0210	DNA helicase
L6424_RS00435	COG3245	cytochrome
L6424_RS00440	COG1063	alcohol dehydrogenase
L6424_RS00445	COG0156	8-amino-7-oxononanoate synthase activity
L6424_RS00455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6424_RS00470	COG3306	glycosyltransferase involved in LPS biosynthesis
L6424_RS00490	COG1561	YicC-like family, N-terminal region
L6424_RS00495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
L6424_RS00500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L6424_RS00510	COG0789	Transcriptional regulator
L6424_RS00515	COG3706	GGDEF domain
L6424_RS00515	COG4251	negative regulation of phosphorylation
L6424_RS00515	COG5001	Diguanylate cyclase
L6424_RS00515	COG2203	Gaf domain
L6424_RS00520	COG3084	Protein conserved in bacteria
L6424_RS00530	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L6424_RS00535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L6424_RS00545	COG1335	isochorismatase
L6424_RS00555	COG1683	Conserved Protein
L6424_RS00560	COG0204	Acyl-transferase
L6424_RS00565	COG0204	Acyl-transferase
L6424_RS00570	COG0606	chelatase, subunit chli
L6424_RS00580	COG3978	acetolactate synthase activity
L6424_RS00590	COG0129	dihydroxy-acid dehydratase activity
L6424_RS00610	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L6424_RS00615	COG0254	rRNA binding
L6424_RS00620	COG0702	epimerase
L6424_RS00625	COG0281	malic enzyme
L6424_RS00635	COG2205	protein histidine kinase activity
L6424_RS00640	COG0745	RESPONSE REGULATOR receiver
L6424_RS00645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L6424_RS00680	COG4310	Domain of unknown function (DUF2172)
L6424_RS00700	COG2089	acid synthase
L6424_RS00710	COG1083	cytidylyl-transferase
L6424_RS00725	COG1028	Short-chain dehydrogenase reductase Sdr
L6424_RS00730	COG0318	PFAM AMP-dependent synthetase and ligase
L6424_RS00745	COG1215	transferase activity, transferring glycosyl groups
L6424_RS00780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6424_RS00795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L6424_RS00820	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L6424_RS00825	COG1086	Polysaccharide biosynthesis protein
L6424_RS00835	COG0366	Alpha amylase catalytic
L6424_RS00850	COG0443	Heat shock 70 kDa protein
L6424_RS00855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L6424_RS00860	COG3045	CreA protein
L6424_RS00880	COG0174	glutamine synthetase
L6424_RS00900	COG3842	ATPase activity
L6424_RS00905	COG1176	ABC-type spermidine putrescine transport system, permease component I
L6424_RS00910	COG1177	transmembrane transport
L6424_RS00915	COG2258	MOSC domain
L6424_RS00930	COG2050	protein possibly involved in aromatic compounds catabolism
L6424_RS00935	COG0514	ATP-dependent DNA helicase (RecQ)
L6424_RS00945	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L6424_RS00955	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
L6424_RS00960	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L6424_RS00970	COG2239	Acts as a magnesium transporter
L6424_RS00975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L6424_RS00975	COG1648	precorrin-2 dehydrogenase activity
L6424_RS00980	COG2116	formate transmembrane transporter activity
L6424_RS00990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6424_RS01000	COG0477	Major facilitator Superfamily
L6424_RS01005	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
L6424_RS01010	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
L6424_RS01030	COG1595	DNA-templated transcription, initiation
L6424_RS01035	COG3806	Anti-sigma factor
L6424_RS01040	COG1968	undecaprenyl-diphosphatase activity
L6424_RS01045	COG0667	Aldo Keto reductase
L6424_RS01050	COG2017	converts alpha-aldose to the beta-anomer
L6424_RS01055	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
L6424_RS01065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L6424_RS01070	COG1609	Transcriptional regulator
L6424_RS01075	COG3250	beta-galactosidase activity
L6424_RS01095	COG0840	transmembrane signaling receptor activity
L6424_RS01125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L6424_RS01130	COG1288	antiporter activity
L6424_RS01135	COG1438	arginine binding
L6424_RS01140	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
L6424_RS01145	COG0540	Belongs to the ATCase OTCase family
L6424_RS01165	COG0688	phosphatidylethanolamine metabolic process
L6424_RS01175	COG3040	lipid binding
L6424_RS01180	COG2207	Transcriptional regulator
L6424_RS01185	COG1979	alcohol dehydrogenase
L6424_RS01190	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
L6424_RS01195	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
L6424_RS01205	COG3681	Belongs to the UPF0597 family
L6424_RS01215	COG0446	pyridine nucleotide-disulphide oxidoreductase
L6424_RS01220	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L6424_RS01225	COG0564	pseudouridine synthase activity
L6424_RS01235	COG0542	response to heat
L6424_RS01240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L6424_RS01245	COG2502	aspartate--ammonia ligase
L6424_RS01250	COG1522	sequence-specific DNA binding
L6424_RS01260	COG5413	integral membrane protein
L6424_RS01285	COG2205	protein histidine kinase activity
L6424_RS01295	COG2204	response regulator
L6424_RS01310	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
L6424_RS01340	COG0243	molybdopterin cofactor binding
L6424_RS01345	COG3005	denitrification pathway
L6424_RS01350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L6424_RS01370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6424_RS01375	COG0569	domain protein
L6424_RS01380	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L6424_RS01405	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L6424_RS01420	COG0250	Participates in transcription elongation, termination and antitermination
L6424_RS01425	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L6424_RS01430	COG0081	regulation of translation
L6424_RS01435	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L6424_RS01440	COG0222	ribosome binding
L6424_RS01445	COG0085	RNA polymerase activity
L6424_RS01450	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L6424_RS01455	COG2964	Protein conserved in bacteria
L6424_RS01460	COG0251	oxidation-reduction process
L6424_RS01470	COG2923	Belongs to the DsrF TusC family
L6424_RS01475	COG2168	tRNA wobble position uridine thiolation
L6424_RS01480	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L6424_RS01485	COG0049	tRNA binding
L6424_RS01490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L6424_RS01495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L6424_RS01500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L6424_RS01545	COG2252	PERMEase
L6424_RS01550	COG2376	Dihydroxyacetone kinase
L6424_RS01555	COG1461	Dihydroxyacetone kinase
L6424_RS01570	COG3284	Transcriptional regulator
L6424_RS01580	COG2957	Belongs to the agmatine deiminase family
L6424_RS01590	COG0628	permease
L6424_RS01595	COG0494	nUDIX hydrolase
L6424_RS01620	COG0753	catalase activity
L6424_RS01625	COG1247	-acetyltransferase
L6424_RS01645	COG2199	diguanylate cyclase activity
L6424_RS01645	COG2203	Gaf domain
L6424_RS01655	COG3842	ATPase activity
L6424_RS01665	COG1176	ABC-type spermidine putrescine transport system, permease component I
L6424_RS01690	COG0583	DNA-binding transcription factor activity
L6424_RS01700	COG1741	Belongs to the pirin family
L6424_RS01705	COG2259	Doxx family
L6424_RS01710	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L6424_RS01715	COG1074	ATP-dependent DNA helicase activity
L6424_RS01720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L6424_RS01730	COG0346	lactoylglutathione lyase activity
L6424_RS01775	COG5001	Diguanylate cyclase
L6424_RS01775	COG4251	negative regulation of phosphorylation
L6424_RS01775	COG3706	GGDEF domain
L6424_RS01775	COG2203	Gaf domain
L6424_RS01780	COG4771	TonB-dependent receptor
L6424_RS01785	COG1278	Cold shock
L6424_RS01815	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L6424_RS02020	COG1357	PFAM Pentapeptide repeats (8 copies)
L6424_RS02070	COG0488	(ABC) transporter
L6424_RS02095	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
L6424_RS02160	COG5642	Protein of unknown function (DUF2384)
L6424_RS02165	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L6424_RS02190	COG4974	Belongs to the 'phage' integrase family
L6424_RS02200	COG2197	response regulator
L6424_RS02205	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L6424_RS02215	COG3047	cAMP biosynthetic process
L6424_RS02220	COG0840	transmembrane signaling receptor activity
L6424_RS02245	COG3135	benzoate transporter
L6424_RS02250	COG1396	sequence-specific DNA binding
L6424_RS02280	COG2926	Belongs to the UPF0265 family
L6424_RS02290	COG3028	Belongs to the UPF0307 family
L6424_RS02295	COG0312	modulator of DNA gyrase
L6424_RS02300	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L6424_RS02305	COG5007	Belongs to the BolA IbaG family
L6424_RS02315	COG2854	intermembrane phospholipid transfer
L6424_RS02320	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L6424_RS02325	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L6424_RS02330	COG1127	ABC transporter
L6424_RS02335	COG0517	IMP dehydrogenase activity
L6424_RS02335	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L6424_RS02340	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L6424_RS02345	COG3117	lipopolysaccharide transmembrane transporter activity
L6424_RS02350	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L6424_RS02355	COG1137	ATPase activity
L6424_RS02360	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
L6424_RS02370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6424_RS02375	COG1660	Displays ATPase and GTPase activities
L6424_RS02380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6424_RS02385	COG3711	transcriptional antiterminator
L6424_RS02385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6424_RS02400	COG3964	amidohydrolase
L6424_RS02430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6424_RS02435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6424_RS02445	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L6424_RS02450	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L6424_RS02455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L6424_RS02460	COG0723	plastoquinol--plastocyanin reductase activity
L6424_RS02465	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L6424_RS02470	COG2857	Cytochrome c1
L6424_RS02475	COG0625	glutathione transferase activity
L6424_RS02480	COG2969	positive regulation of protein catabolic process
L6424_RS02485	COG2823	Periplasmic or secreted lipoprotein
L6424_RS02490	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L6424_RS02495	COG0792	nuclease activity
L6424_RS02500	COG3107	peptidoglycan biosynthetic process
L6424_RS02505	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
L6424_RS02515	COG2001	Belongs to the MraZ family
L6424_RS02520	COG0275	rRNA processing
L6424_RS02525	COG3116	cell division
L6424_RS02530	COG0768	penicillin binding
L6424_RS02540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L6424_RS02545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L6424_RS02550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L6424_RS02555	COG0772	Belongs to the SEDS family
L6424_RS02560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L6424_RS02565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L6424_RS02570	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L6424_RS02575	COG0849	cell division
L6424_RS02580	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L6424_RS02585	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
L6424_RS02595	COG0653	protein targeting
L6424_RS02605	COG0494	nUDIX hydrolase
L6424_RS02610	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L6424_RS02615	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
L6424_RS02630	COG1459	type II secretion system
L6424_RS02635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L6424_RS02660	COG2186	Transcriptional regulator
L6424_RS02665	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
L6424_RS02670	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6424_RS02675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L6424_RS02685	COG0840	transmembrane signaling receptor activity
L6424_RS02690	COG0840	transmembrane signaling receptor activity
L6424_RS02695	COG1752	Esterase of the alpha-beta hydrolase superfamily
L6424_RS02700	COG1049	propionate catabolic process, 2-methylcitrate cycle
L6424_RS02705	COG2200	EAL domain
L6424_RS02715	COG1280	lysine exporter protein (LysE YggA)
L6424_RS02725	COG0523	cobalamin synthesis protein
L6424_RS02730	COG0477	Major facilitator Superfamily
L6424_RS02745	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L6424_RS02750	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L6424_RS02785	COG3314	Sporulation integral membrane protein YlbJ
L6424_RS02790	COG0784	Response regulator, receiver
L6424_RS02790	COG0835	chemotaxis
L6424_RS02800	COG1444	tRNA N-acetyltransferase activity
L6424_RS02825	COG1803	Methylglyoxal synthase
L6424_RS02840	COG0252	asparaginase activity
L6424_RS02860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6424_RS02860	COG1263	PTS System
L6424_RS02865	COG0366	Alpha amylase catalytic
L6424_RS02870	COG0110	maltose O-acetyltransferase activity
L6424_RS02875	COG1522	sequence-specific DNA binding
L6424_RS02880	COG5006	permease, DMT superfamily
L6424_RS02890	COG1012	belongs to the aldehyde dehydrogenase family
L6424_RS02895	COG1177	transmembrane transport
L6424_RS02900	COG1176	ABC-type spermidine putrescine transport system, permease component I
L6424_RS02905	COG3842	ATPase activity
L6424_RS02910	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L6424_RS02915	COG0583	DNA-binding transcription factor activity
L6424_RS02920	COG1757	Na H antiporter
L6424_RS02960	COG0297	glycogen (starch) synthase activity
L6424_RS02965	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L6424_RS02970	COG2813	Specifically methylates the guanine in position
L6424_RS02975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L6424_RS02980	COG3706	GGDEF domain
L6424_RS02980	COG2203	Gaf domain
L6424_RS02980	COG4251	negative regulation of phosphorylation
L6424_RS02980	COG5001	Diguanylate cyclase
L6424_RS02990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L6424_RS03000	COG2995	paraquat-inducible protein a
L6424_RS03005	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L6424_RS03005	COG3008	intermembrane lipid transfer
L6424_RS03010	COG3009	Protein conserved in bacteria
L6424_RS03015	COG2885	chlorophyll binding
L6424_RS03015	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L6424_RS03025	COG3240	lipase activity
L6424_RS03030	COG3111	PFAM Bacterial OB fold (BOF) protein
L6424_RS03040	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
L6424_RS03045	COG1194	a g-specific adenine glycosylase
L6424_RS03055	COG3409	Peptidoglycan-binding domain 1 protein
L6424_RS03055	COG3267	Type II secretory pathway component ExeA
L6424_RS03060	COG0617	tRNA 3'-terminal CCA addition
L6424_RS03075	COG1346	cytolysis
L6424_RS03080	COG1380	Effector of murein hydrolase LrgA
L6424_RS03085	COG0583	DNA-binding transcription factor activity
L6424_RS03115	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L6424_RS03120	COG0306	phosphate transporter
L6424_RS03125	COG1392	Phosphate transport regulator
L6424_RS03140	COG1560	Kdo2-lipid A biosynthetic process
L6424_RS03145	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L6424_RS03145	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L6424_RS03150	COG1538	Outer membrane efflux protein
L6424_RS03155	COG0494	nUDIX hydrolase
L6424_RS03160	COG3151	Protein conserved in bacteria
L6424_RS03170	COG3150	esterase
L6424_RS03175	COG1051	belongs to the nudix hydrolase family
L6424_RS03190	COG1566	PFAM secretion protein HlyD family protein
L6424_RS03195	COG1289	transmembrane transporter activity
L6424_RS03215	COG0583	DNA-binding transcription factor activity
L6424_RS03255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6424_RS03275	COG0204	Acyl-transferase
L6424_RS03280	COG1842	Phage shock protein A
L6424_RS03295	COG2827	Endonuclease containing a URI domain
L6424_RS03305	COG2962	Rard protein
L6424_RS03310	COG1573	uracil-dna glycosylase
L6424_RS03315	COG0697	spore germination
L6424_RS03320	COG0583	DNA-binding transcription factor activity
L6424_RS03325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L6424_RS03330	COG1121	(ABC) transporter
L6424_RS03335	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
L6424_RS03355	COG0739	heme binding
L6424_RS03365	COG3068	Protein conserved in bacteria
L6424_RS03385	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L6424_RS03390	COG0582	viral genome integration into host DNA
L6424_RS03435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6424_RS03440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6424_RS03520	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L6424_RS03575	COG2003	Belongs to the UPF0758 family
L6424_RS03620	COG5377	YqaJ viral recombinase family
L6424_RS03630	COG1309	transcriptional regulator
L6424_RS03645	COG1136	(ABC) transporter
L6424_RS03660	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L6424_RS03670	COG1546	Belongs to the CinA family
L6424_RS03675	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L6424_RS03685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L6424_RS03690	COG0527	aspartate kinase activity
L6424_RS03695	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
L6424_RS03730	COG1686	Belongs to the peptidase S11 family
L6424_RS03735	COG0586	Pfam SNARE associated Golgi protein
L6424_RS03740	COG1253	flavin adenine dinucleotide binding
L6424_RS03745	COG0525	valine-tRNA ligase activity
L6424_RS03750	COG2927	DNA polymerase III (CHI subunit)
L6424_RS03755	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L6424_RS03760	COG0795	lipopolysaccharide-transporting ATPase activity
L6424_RS03765	COG0795	lipopolysaccharide-transporting ATPase activity
L6424_RS03915	COG4695	Portal protein
L6424_RS03995	COG4974	Belongs to the 'phage' integrase family
L6424_RS04000	COG0582	viral genome integration into host DNA
L6424_RS04010	COG1160	GTP binding
L6424_RS04070	COG0004	ammonium transporteR
L6424_RS04075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L6424_RS04085	COG2165	general secretion pathway protein
L6424_RS04090	COG0084	hydrolase, TatD family'
L6424_RS04095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6424_RS04105	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
L6424_RS04110	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
L6424_RS04115	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
L6424_RS04120	COG0813	purine-nucleoside phosphorylase activity
L6424_RS04125	COG5001	Diguanylate cyclase
L6424_RS04125	COG3447	MASE1 domain protein
L6424_RS04125	COG5002	protein histidine kinase activity
L6424_RS04135	COG0560	Phosphoserine phosphatase
L6424_RS04160	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
L6424_RS04170	COG0776	regulation of translation
L6424_RS04185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L6424_RS04190	COG0735	belongs to the Fur family
L6424_RS04215	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
L6424_RS04220	COG0513	Belongs to the DEAD box helicase family
L6424_RS04225	COG3022	response to hydroperoxide
L6424_RS04240	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L6424_RS04245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6424_RS04250	COG0762	integral membrane protein
L6424_RS04255	COG1872	DUF167
L6424_RS04270	COG4166	transmembrane transport
L6424_RS04290	COG1024	Enoyl-CoA hydratase
L6424_RS04305	COG4221	oxidoreductase activity
L6424_RS04310	COG0442	prolyl-tRNA aminoacylation
L6424_RS04315	COG0840	transmembrane signaling receptor activity
L6424_RS04320	COG0632	four-way junction helicase activity
L6424_RS04325	COG2255	four-way junction helicase activity
L6424_RS04330	COG1271	oxidase subunit
L6424_RS04335	COG1294	oxidase, subunit
L6424_RS04340	COG4890	Cyd operon protein YbgT
L6424_RS04345	COG3790	cyd operon protein YbgE
L6424_RS04350	COG0824	Thioesterase
L6424_RS04355	COG0811	peptide transport
L6424_RS04370	COG0823	Involved in the tonB-independent uptake of proteins
L6424_RS04375	COG2885	chlorophyll binding
L6424_RS04380	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
L6424_RS04455	COG0840	transmembrane signaling receptor activity
L6424_RS04460	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L6424_RS04465	COG0676	glucose-6-phosphate 1-epimerase activity
L6424_RS04470	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L6424_RS04475	COG1640	4-alpha-glucanotransferase
L6424_RS04480	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L6424_RS04500	COG1051	belongs to the nudix hydrolase family
L6424_RS04505	COG2130	NADP-dependent
L6424_RS04510	COG1764	response to oxidative stress
L6424_RS04515	COG1846	Transcriptional regulator
L6424_RS04550	COG0561	phosphatase activity
L6424_RS04565	COG0733	neurotransmitter:sodium symporter activity
L6424_RS04575	COG0733	neurotransmitter:sodium symporter activity
L6424_RS04600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6424_RS04615	COG1794	racemase activity, acting on amino acids and derivatives
L6424_RS04630	COG2731	YhcH YjgK YiaL family protein
L6424_RS04640	COG0668	transmembrane transport
L6424_RS04650	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6424_RS04705	COG0583	DNA-binding transcription factor activity
L6424_RS04710	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L6424_RS04720	COG0488	(ABC) transporter
L6424_RS04725	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L6424_RS04725	COG0517	IMP dehydrogenase activity
L6424_RS04730	COG1585	Membrane protein implicated in regulation of membrane protease activity
L6424_RS04735	COG0330	HflC and HflK could
L6424_RS04740	COG1648	precorrin-2 dehydrogenase activity
L6424_RS04740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L6424_RS04745	COG0175	sulfate reduction
L6424_RS04750	COG2895	sulfate adenylyltransferase (ATP) activity
L6424_RS04755	COG0471	metal ion transport
L6424_RS04755	COG3273	potassium ion transport
L6424_RS04760	COG0529	Catalyzes the synthesis of activated sulfate
L6424_RS04785	COG0840	transmembrane signaling receptor activity
L6424_RS04805	COG1136	(ABC) transporter
L6424_RS04820	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
L6424_RS04835	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L6424_RS04840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L6424_RS04845	COG0163	prenyltransferase activity
L6424_RS04860	COG1131	(ABC) transporter
L6424_RS04865	COG0842	Transport permease protein
L6424_RS04870	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
L6424_RS04875	COG1924	4 iron, 4 sulfur cluster binding
L6424_RS04895	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
L6424_RS04900	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
L6424_RS04905	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L6424_RS04915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L6424_RS04920	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L6424_RS04925	COG1489	DNA binding
L6424_RS04935	COG1643	Atp-dependent helicase
L6424_RS04940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6424_RS04945	COG0346	lactoylglutathione lyase activity
L6424_RS04955	COG2076	Multidrug Resistance protein
L6424_RS04965	COG3437	response regulator, receiver
L6424_RS04965	COG0784	Response regulator, receiver
L6424_RS04975	COG0671	phosphoesterase, PA-phosphatase related
L6424_RS04990	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L6424_RS04995	COG0038	chloride channel
L6424_RS05005	COG0316	Belongs to the HesB IscA family
L6424_RS05030	COG1280	lysine exporter protein (LysE YggA)
L6424_RS05065	COG0582	viral genome integration into host DNA
L6424_RS05080	COG3311	Transcriptional regulator
L6424_RS05090	COG0515	serine threonine protein kinase
L6424_RS05115	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
L6424_RS05140	COG5377	YqaJ viral recombinase family
L6424_RS05175	COG2003	Belongs to the UPF0758 family
L6424_RS05225	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L6424_RS05230	COG0732	type I restriction modification DNA specificity domain
L6424_RS05235	COG1401	restriction endodeoxyribonuclease activity
L6424_RS05245	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L6424_RS05300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6424_RS05305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6424_RS05320	COG4584	PFAM Integrase catalytic
L6424_RS05325	COG1484	DNA-dependent DNA replication
L6424_RS05360	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L6424_RS05375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6424_RS05405	COG0745	RESPONSE REGULATOR receiver
L6424_RS05410	COG3104	oligopeptide transport
L6424_RS05415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L6424_RS05420	COG1555	photosystem II stabilization
L6424_RS05430	COG2350	Protein conserved in bacteria
L6424_RS05435	COG2917	probably involved in intracellular septation
L6424_RS05440	COG0076	glutamate decarboxylase activity
L6424_RS05445	COG1272	protein, Hemolysin III
L6424_RS05450	COG0569	domain protein
L6424_RS05450	COG2985	domain, Protein
L6424_RS05460	COG0784	Response regulator, receiver
L6424_RS05460	COG0835	chemotaxis
L6424_RS05465	COG2755	lipolytic protein G-D-S-L family
L6424_RS05470	COG4181	ATPase activity
L6424_RS05475	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L6424_RS05480	COG1090	epimerase
L6424_RS05485	COG2200	EAL domain
L6424_RS05490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6424_RS05495	COG2234	aminopeptidase activity
L6424_RS05495	COG4935	Belongs to the peptidase S8 family
L6424_RS05500	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L6424_RS05505	COG3171	Protein conserved in bacteria
L6424_RS05510	COG2066	Belongs to the glutaminase family
L6424_RS05515	COG2897	thiosulfate sulfurtransferase activity
L6424_RS05530	COG1132	(ABC) transporter
L6424_RS05555	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
L6424_RS05560	COG3300	MHYT domain
L6424_RS05560	COG5001	Diguanylate cyclase
L6424_RS05570	COG2207	Transcriptional regulator
L6424_RS05575	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L6424_RS05580	COG3059	membrane
L6424_RS05595	COG4628	conserved protein (DUF2132)
L6424_RS05600	COG0688	phosphatidylethanolamine metabolic process
L6424_RS05605	COG1162	GTPase activity
L6424_RS05610	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L6424_RS05650	COG1278	Cold shock
L6424_RS05660	COG0840	transmembrane signaling receptor activity
L6424_RS05665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L6424_RS05715	COG0848	biopolymer transport protein
L6424_RS05720	COG0811	peptide transport
L6424_RS05725	COG0811	peptide transport
L6424_RS05735	COG4206	TonB-dependent receptor
L6424_RS05740	COG4174	ABC transporter (Permease)
L6424_RS05745	COG4239	(ABC) transporter, permease
L6424_RS05755	COG0444	Belongs to the ABC transporter superfamily
L6424_RS05760	COG4608	Belongs to the ABC transporter superfamily
L6424_RS05765	COG2195	Cleaves the N-terminal amino acid of tripeptides
L6424_RS05770	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
L6424_RS05775	COG1073	alpha beta
L6424_RS05790	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
L6424_RS05825	COG0243	molybdopterin cofactor binding
L6424_RS05840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6424_RS05840	COG1116	anion transmembrane transporter activity
L6424_RS05845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6424_RS05850	COG1116	anion transmembrane transporter activity
L6424_RS05855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6424_RS05855	COG2146	nitrite reductase [NAD(P)H] activity
L6424_RS05860	COG2146	nitrite reductase [NAD(P)H] activity
L6424_RS05860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6424_RS05865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6424_RS05870	COG2313	pseudouridylate synthase activity
L6424_RS05880	COG1858	cytochrome C peroxidase
L6424_RS05915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6424_RS05920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6424_RS05945	COG2986	histidine ammonia-lyase
L6424_RS05980	COG1028	Short-chain dehydrogenase reductase Sdr
L6424_RS05985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L6424_RS05995	COG0521	Mo-molybdopterin cofactor biosynthetic process
L6424_RS06005	COG2966	Psort location CytoplasmicMembrane, score
L6424_RS06010	COG3610	response to peptide
L6424_RS06020	COG4175	Glycine betaine
L6424_RS06025	COG4176	ABC-type proline glycine betaine transport system permease component
L6424_RS06030	COG2113	Glycine betaine
L6424_RS06035	COG0175	sulfate reduction
L6424_RS06040	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6424_RS06045	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L6424_RS06050	COG0384	phenazine biosynthesis protein PhzF
L6424_RS06055	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L6424_RS06070	COG0786	glutamate:sodium symporter activity
L6424_RS06075	COG0252	asparaginase activity
L6424_RS06080	COG3139	Protein of unknown function (DUF1315)
L6424_RS06100	COG0616	signal peptide processing
L6424_RS06105	COG1902	pentaerythritol trinitrate reductase activity
L6424_RS06105	COG0446	pyridine nucleotide-disulphide oxidoreductase
L6424_RS06110	COG0778	Nitroreductase
L6424_RS06135	COG2264	protein methyltransferase activity
L6424_RS06140	COG0604	alcohol dehydrogenase
L6424_RS06145	COG0583	DNA-binding transcription factor activity
L6424_RS06150	COG2190	(PTS) system
L6424_RS06150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6424_RS06150	COG1263	PTS System
L6424_RS06155	COG4145	pantothenate transmembrane transporter activity
L6424_RS06165	COG0439	Biotin carboxylase
L6424_RS06170	COG0511	ligase activity, forming carbon-carbon bonds
L6424_RS06175	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L6424_RS06180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6424_RS06190	COG5001	Diguanylate cyclase
L6424_RS06190	COG3300	MHYT domain
L6424_RS06210	COG3381	protein complex oligomerization
L6424_RS06225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L6424_RS06235	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L6424_RS06240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L6424_RS06240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L6424_RS06260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L6424_RS06265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L6424_RS06270	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L6424_RS06275	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L6424_RS06280	COG4172	Belongs to the ABC transporter superfamily
L6424_RS06290	COG0601	transmembrane transport
L6424_RS06300	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L6424_RS06305	COG0142	geranyltranstransferase activity
L6424_RS06310	COG1722	exodeoxyribonuclease VII activity
L6424_RS06315	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6424_RS06320	COG1360	Flagellar Motor Protein
L6424_RS06335	COG1534	Rna-binding protein
L6424_RS06340	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
L6424_RS06350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L6424_RS06355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L6424_RS06360	COG0149	triose-phosphate isomerase activity
L6424_RS06365	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L6424_RS06380	COG0779	Required for maturation of 30S ribosomal subunits
L6424_RS06385	COG0195	Participates in both transcription termination and antitermination
L6424_RS06390	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L6424_RS06395	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L6424_RS06400	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L6424_RS06405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L6424_RS06410	COG1185	polyribonucleotide nucleotidyltransferase activity
L6424_RS06415	COG2211	Major facilitator Superfamily
L6424_RS06425	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L6424_RS06435	COG0114	fumarate hydratase activity
L6424_RS06445	COG1966	Carbon starvation protein
L6424_RS06450	COG3279	Response regulator of the LytR AlgR family
L6424_RS06455	COG3275	phosphorelay sensor kinase activity
L6424_RS06525	COG0312	modulator of DNA gyrase
L6424_RS06530	COG0312	modulator of DNA gyrase
L6424_RS06540	COG4974	Belongs to the 'phage' integrase family
L6424_RS06545	COG1970	mechanosensitive ion channel activity
L6424_RS06550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L6424_RS06560	COG0789	Transcriptional regulator
L6424_RS06575	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L6424_RS06580	COG3545	Serine hydrolase
L6424_RS06590	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L6424_RS06595	COG0321	lipoyl(octanoyl) transferase activity
L6424_RS06600	COG2921	Belongs to the UPF0250 family
L6424_RS06605	COG1686	Belongs to the peptidase S11 family
L6424_RS06610	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L6424_RS06615	COG2951	lytic endotransglycosylase activity
L6424_RS06620	COG0772	Belongs to the SEDS family
L6424_RS06625	COG0768	penicillin binding
L6424_RS06630	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
L6424_RS06635	COG0799	negative regulation of ribosome biogenesis
L6424_RS06640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L6424_RS06660	COG0495	leucyl-tRNA aminoacylation
L6424_RS06665	COG2888	peptidyl-tyrosine sulfation
L6424_RS06670	COG0815	Transfers the fatty acyl group on membrane lipoproteins
L6424_RS06675	COG4535	Mg2 and Co2 transporter CorC
L6424_RS06680	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L6424_RS06685	COG1702	phosphate starvation-inducible protein PhoH
L6424_RS06690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L6424_RS06695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L6424_RS06700	COG1335	isochorismatase
L6424_RS06710	COG3706	GGDEF domain
L6424_RS06725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L6424_RS06745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L6424_RS06755	COG3647	Membrane
L6424_RS06760	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L6424_RS06770	COG0516	GMP reductase activity
L6424_RS06780	COG0642	Histidine kinase
L6424_RS06815	COG4106	trans-aconitate 2-methyltransferase activity
L6424_RS06820	COG3214	Protein conserved in bacteria
L6424_RS06845	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
L6424_RS06850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L6424_RS06855	COG1053	succinate dehydrogenase
L6424_RS06865	COG0584	glycerophosphoryl diester phosphodiesterase
L6424_RS06870	COG1511	domain protein
L6424_RS06870	COG3264	Mechanosensitive ion channel
L6424_RS06880	COG0739	heme binding
L6424_RS06895	COG0583	DNA-binding transcription factor activity
L6424_RS06910	COG0840	transmembrane signaling receptor activity
L6424_RS06915	COG0583	DNA-binding transcription factor activity
L6424_RS06920	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
L6424_RS06960	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L6424_RS06965	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L6424_RS06975	COG0338	D12 class N6 adenine-specific DNA methyltransferase
L6424_RS06980	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L6424_RS06990	COG0180	Tryptophanyl-tRNA synthetase
L6424_RS07005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L6424_RS07015	COG1012	belongs to the aldehyde dehydrogenase family
L6424_RS07030	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L6424_RS07045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L6424_RS07055	COG0674	pyruvate-flavodoxin oxidoreductase activity
L6424_RS07055	COG1013	pyruvate-flavodoxin oxidoreductase activity
L6424_RS07055	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L6424_RS07055	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6424_RS07065	COG0366	Alpha amylase catalytic
L6424_RS07075	COG3097	Belongs to the UPF0267 family
L6424_RS07095	COG0471	metal ion transport
L6424_RS07095	COG0490	domain, Protein
L6424_RS07140	COG0012	GTP binding
L6424_RS07145	COG0193	aminoacyl-tRNA hydrolase activity
L6424_RS07150	COG0737	Belongs to the 5'-nucleotidase family
L6424_RS07155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L6424_RS07165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
L6424_RS07170	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L6424_RS07175	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
L6424_RS07180	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L6424_RS07185	COG2890	protein-(glutamine-N5) methyltransferase activity
L6424_RS07195	COG2912	Transglutaminase-like superfamily
L6424_RS07200	COG2877	3-deoxy-8-phosphooctulonate synthase activity
L6424_RS07205	COG1301	dicarboxylic acid transport
L6424_RS07225	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L6424_RS07240	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L6424_RS07245	COG1115	amino acid carrier protein
L6424_RS07260	COG0714	Associated with various cellular activities
L6424_RS07275	COG3104	oligopeptide transport
L6424_RS07280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L6424_RS07285	COG1678	Uncharacterized ACR, COG1678
L6424_RS07295	COG0189	ligase activity
L6424_RS07300	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L6424_RS07310	COG3091	SprT-like family
L6424_RS07320	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L6424_RS07340	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L6424_RS07345	COG0739	heme binding
L6424_RS07350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L6424_RS07355	COG3408	Glycogen debranching enzyme
L6424_RS07355	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
L6424_RS07365	COG1881	PFAM PEBP family protein
L6424_RS07370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L6424_RS07375	COG0583	DNA-binding transcription factor activity
L6424_RS07385	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L6424_RS07395	COG0583	DNA-binding transcription factor activity
L6424_RS07400	COG1028	Short-chain dehydrogenase reductase Sdr
L6424_RS07405	COG0616	signal peptide processing
L6424_RS07410	COG3724	N-succinylarginine dihydrolase activity
L6424_RS07430	COG0840	transmembrane signaling receptor activity
L6424_RS07440	COG2971	BadF BadG BcrA BcrD
L6424_RS07450	COG4608	Belongs to the ABC transporter superfamily
L6424_RS07455	COG0444	Belongs to the ABC transporter superfamily
L6424_RS07460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6424_RS07465	COG0601	transmembrane transport
L6424_RS07470	COG4166	transmembrane transport
L6424_RS07475	COG0784	Response regulator, receiver
L6424_RS07475	COG2205	protein histidine kinase activity
L6424_RS07505	COG3220	belongs to the UPF0276 family
L6424_RS07535	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
L6424_RS07540	COG1289	transmembrane transporter activity
L6424_RS07545	COG0303	'Molybdopterin
L6424_RS07550	COG0746	molybdenum cofactor guanylyltransferase activity
L6424_RS07560	COG4662	Binding-protein-dependent transport system inner membrane component
L6424_RS07570	COG2204	response regulator
L6424_RS07575	COG3852	Histidine kinase
L6424_RS07585	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L6424_RS07620	COG3383	formate dehydrogenase (NAD+) activity
L6424_RS07620	COG3383	formate dehydrogenase (NAD+) activity
L6424_RS07625	COG0437	4 iron, 4 sulfur cluster binding
L6424_RS07640	COG0281	malic enzyme
L6424_RS07660	COG2706	6-phosphogluconolactonase activity
L6424_RS07710	COG0582	viral genome integration into host DNA
L6424_RS07715	COG1196	nuclear chromosome segregation
L6424_RS07715	COG3264	Mechanosensitive ion channel
L6424_RS07720	COG0469	pyruvate kinase activity
L6424_RS07735	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L6424_RS07735	COG4651	solute:proton antiporter activity
L6424_RS07745	COG2974	May be involved in recombination
L6424_RS07755	COG0420	3'-5' exonuclease activity
L6424_RS07760	COG0419	ATPase involved in DNA repair
L6424_RS07770	COG3038	cytochrome b561
L6424_RS07785	COG2190	(PTS) system
L6424_RS07795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6424_RS07800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6424_RS07805	COG0542	response to heat
L6424_RS07820	COG1720	tRNA m6t6A37 methyltransferase activity
L6424_RS07840	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
L6424_RS07845	COG4988	ABC transporter
L6424_RS07860	COG0745	RESPONSE REGULATOR receiver
L6424_RS07870	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L6424_RS07885	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
L6424_RS07890	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
L6424_RS07900	COG0083	homoserine kinase activity
L6424_RS07905	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L6424_RS07915	COG0488	(ABC) transporter
L6424_RS07920	COG1204	response to ionizing radiation
L6424_RS07935	COG0813	purine-nucleoside phosphorylase activity
L6424_RS07950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6424_RS07950	COG2205	protein histidine kinase activity
L6424_RS07955	COG3384	dioxygenase
L6424_RS07965	COG1283	sodium-dependent phosphate transmembrane transporter activity
L6424_RS07975	COG0531	amino acid
L6424_RS07985	COG0531	amino acid
L6424_RS08000	COG1396	sequence-specific DNA binding
L6424_RS08000	COG1917	Cupin 2, conserved barrel domain protein
L6424_RS08005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6424_RS08030	COG3152	Membrane
L6424_RS08050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L6424_RS08055	COG2375	cellular response to nickel ion
L6424_RS08065	COG1136	(ABC) transporter
L6424_RS08065	COG0577	efflux transmembrane transporter activity
L6424_RS08070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6424_RS08080	COG1227	inorganic diphosphatase activity
L6424_RS08085	COG0497	DNA recombination
L6424_RS08090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L6424_RS08095	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L6424_RS08100	COG0443	Heat shock 70 kDa protein
L6424_RS08105	COG0484	heat shock protein binding
L6424_RS08135	COG1285	pathogenesis
L6424_RS08150	COG0640	Transcriptional regulator
L6424_RS08180	COG0095	Lipoate-protein ligase
L6424_RS08200	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6424_RS08205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6424_RS08225	COG0708	Exodeoxyribonuclease III
L6424_RS08240	COG2211	Major facilitator Superfamily
L6424_RS08295	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L6424_RS08300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L6424_RS08305	COG1845	cytochrome c oxidase, subunit III
L6424_RS08310	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L6424_RS08315	COG0109	protoheme IX farnesyltransferase activity
L6424_RS08320	COG2814	Major facilitator Superfamily
L6424_RS08330	COG2175	clavaminate synthase activity
L6424_RS08335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6424_RS08340	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L6424_RS08345	COG4521	taurine ABC transporter
L6424_RS08355	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6424_RS08375	COG1988	membrane-bound metal-dependent
L6424_RS08395	COG0159	tryptophan synthase activity
L6424_RS08400	COG0133	tryptophan synthase activity
L6424_RS08405	COG0134	indole-3-glycerol-phosphate synthase activity
L6424_RS08405	COG0135	phosphoribosylanthranilate isomerase activity
L6424_RS08410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L6424_RS08415	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L6424_RS08415	COG0512	Glutamine amidotransferase of anthranilate synthase
L6424_RS08420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L6424_RS08430	COG0009	L-threonylcarbamoyladenylate synthase
L6424_RS08440	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L6424_RS08450	COG1946	Acyl-CoA thioesterase
L6424_RS08470	COG1309	transcriptional regulator
L6424_RS08475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6424_RS08480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6424_RS08510	COG1086	Polysaccharide biosynthesis protein
L6424_RS08535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L6424_RS08550	COG1091	dTDP-4-dehydrorhamnose reductase activity
L6424_RS08555	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
L6424_RS08590	COG3132	Protein of unknown function, DUF480
L6424_RS08630	COG1278	Cold shock
L6424_RS08665	COG1349	DNA-binding transcription factor activity
L6424_RS08670	COG1882	Formate acetyltransferase
L6424_RS08675	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L6424_RS08680	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L6424_RS08710	COG0622	Phosphoesterase
L6424_RS08725	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
L6424_RS08730	COG0784	Response regulator, receiver
L6424_RS08730	COG0835	chemotaxis
L6424_RS08735	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L6424_RS08740	COG1815	bacterial-type flagellum-dependent cell motility
L6424_RS08760	COG4787	bacterial-type flagellum-dependent cell motility
L6424_RS08770	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
L6424_RS08775	COG1706	bacterial-type flagellum-dependent cell motility
L6424_RS08780	COG1705	Flagellar rod assembly protein muramidase FlgJ
L6424_RS08780	COG3951	Flagellar rod assembly protein muramidase FlgJ
L6424_RS08785	COG1256	bacterial-type flagellum assembly
L6424_RS08795	COG2239	Acts as a magnesium transporter
L6424_RS08805	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L6424_RS08810	COG2716	regulation of RNA biosynthetic process
L6424_RS08835	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L6424_RS08840	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L6424_RS08845	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L6424_RS08850	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L6424_RS08870	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L6424_RS08885	COG0590	tRNA wobble adenosine to inosine editing
L6424_RS08890	COG0573	inorganic phosphate transmembrane transporter activity
L6424_RS08895	COG0581	inorganic phosphate transmembrane transporter activity
L6424_RS08900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L6424_RS08905	COG0704	Plays a role in the regulation of phosphate uptake
L6424_RS08910	COG1253	flavin adenine dinucleotide binding
L6424_RS08925	COG0531	amino acid
L6424_RS08940	COG1126	abc transporter atp-binding protein
L6424_RS08945	COG0765	amino acid transport
L6424_RS08950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6424_RS08960	COG2271	Major facilitator Superfamily
L6424_RS08975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L6424_RS09000	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L6424_RS09005	COG0477	Major facilitator Superfamily
L6424_RS09010	COG0123	including yeast histone deacetylase and acetoin utilization protein
L6424_RS09020	COG1199	ATP-dependent helicase activity
L6424_RS09170	COG4695	Portal protein
L6424_RS09225	COG0732	type I restriction modification DNA specificity domain
L6424_RS09225	COG0827	DNA restriction-modification system
L6424_RS09290	COG4974	Belongs to the 'phage' integrase family
L6424_RS09305	COG1448	Aminotransferase
L6424_RS09310	COG0433	COG0433 Predicted ATPase
L6424_RS09325	COG2333	competence protein COMEC
L6424_RS09325	COG0658	competence protein
L6424_RS09335	COG1663	tetraacyldisaccharide 4'-kinase activity
L6424_RS09340	COG2835	tetraacyldisaccharide 4'-kinase activity
L6424_RS09345	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
L6424_RS09350	COG2197	response regulator
L6424_RS09355	COG0322	excinuclease ABC activity
L6424_RS09410	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
L6424_RS09415	COG0437	4 iron, 4 sulfur cluster binding
L6424_RS09420	COG3301	Polysulphide reductase, NrfD
L6424_RS09425	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L6424_RS09435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L6424_RS09465	COG2199	diguanylate cyclase activity
L6424_RS09465	COG2203	Gaf domain
L6424_RS09495	COG2119	membrane
L6424_RS09500	COG0023	Translation Initiation Factor
L6424_RS09540	COG2205	protein histidine kinase activity
L6424_RS09540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6424_RS09550	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
L6424_RS09560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L6424_RS09565	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L6424_RS09570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L6424_RS09575	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
L6424_RS09580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L6424_RS09595	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L6424_RS09600	COG0505	Belongs to the CarA family
L6424_RS09605	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L6424_RS09610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L6424_RS09645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6424_RS09650	COG0513	Belongs to the DEAD box helicase family
L6424_RS09660	COG4104	PAAR repeat-containing protein
L6424_RS09675	COG0789	Transcriptional regulator
L6424_RS09690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6424_RS09695	COG0765	amino acid transport
L6424_RS09700	COG1126	abc transporter atp-binding protein
L6424_RS09705	COG0493	'glutamate synthase
L6424_RS09710	COG0067	glutamate synthase
L6424_RS09710	COG0069	glutamate synthase activity
L6424_RS09710	COG0070	glutamate synthase
L6424_RS09715	COG1242	4 iron, 4 sulfur cluster binding
L6424_RS09780	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
L6424_RS09785	COG0574	Belongs to the PEP-utilizing enzyme family
L6424_RS09785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L6424_RS09830	COG1464	Belongs to the NlpA lipoprotein family
L6424_RS09835	COG0671	phosphoesterase, PA-phosphatase related
L6424_RS09840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L6424_RS09845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L6424_RS09855	COG0101	tRNA pseudouridine synthase activity
L6424_RS09860	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L6424_RS09865	COG0285	dihydrofolate synthase activity
L6424_RS09870	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
L6424_RS09875	COG2920	part of a sulfur-relay system
L6424_RS09880	COG1289	transmembrane transporter activity
L6424_RS09885	COG0670	Belongs to the BI1 family
L6424_RS09905	COG2194	sulfuric ester hydrolase activity
L6424_RS09915	COG0392	lysyltransferase activity
L6424_RS09915	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
L6424_RS09925	COG0840	transmembrane signaling receptor activity
L6424_RS09930	COG5001	Diguanylate cyclase
L6424_RS09935	COG0564	pseudouridine synthase activity
L6424_RS09950	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
L6424_RS09960	COG0625	glutathione transferase activity
L6424_RS09965	COG0625	glutathione transferase activity
L6424_RS09975	COG0367	asparagine synthase
L6424_RS09985	COG4651	solute:proton antiporter activity
L6424_RS09985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L6424_RS09990	COG0647	UMP catabolic process
L6424_RS09995	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L6424_RS10000	COG1902	pentaerythritol trinitrate reductase activity
L6424_RS10005	COG1253	flavin adenine dinucleotide binding
L6424_RS10015	COG0277	FAD linked oxidase domain protein
L6424_RS10015	COG0247	lactate metabolic process
L6424_RS10025	COG2050	protein possibly involved in aromatic compounds catabolism
L6424_RS10035	COG2056	Na+-H+ antiporter family
L6424_RS10040	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L6424_RS10055	COG0346	lactoylglutathione lyase activity
L6424_RS10060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L6424_RS10065	COG4660	Part of a membrane complex involved in electron transport
L6424_RS10070	COG4659	FMN binding
L6424_RS10075	COG4658	electron transport chain
L6424_RS10085	COG2878	Part of a membrane complex involved in electron transport
L6424_RS10090	COG4657	Part of a membrane complex involved in electron transport
L6424_RS10095	COG0697	spore germination
L6424_RS10115	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L6424_RS10120	COG1288	antiporter activity
L6424_RS10125	COG0436	Aminotransferase
L6424_RS10135	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L6424_RS10140	COG2027	D-alanyl-D-alanine carboxypeptidase
L6424_RS10145	COG1061	Type III restriction enzyme res subunit
L6424_RS10150	COG1566	PFAM secretion protein HlyD family protein
L6424_RS10160	COG1966	Carbon starvation protein
L6424_RS10165	COG3279	Response regulator of the LytR AlgR family
L6424_RS10170	COG3275	phosphorelay sensor kinase activity
L6424_RS10175	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
L6424_RS10175	COG2199	diguanylate cyclase activity
L6424_RS10180	COG1012	belongs to the aldehyde dehydrogenase family
L6424_RS10180	COG1454	alcohol dehydrogenase
L6424_RS10190	COG2095	MarC family integral membrane protein
L6424_RS10200	COG0601	transmembrane transport
L6424_RS10205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6424_RS10220	COG0861	Integral membrane protein TerC family
L6424_RS10225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L6424_RS10235	COG1301	dicarboxylic acid transport
L6424_RS10250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L6424_RS10265	COG0537	adenosine 5'-monophosphoramidase activity
L6424_RS10300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6424_RS10305	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6424_RS10315	COG2354	Protein conserved in bacteria
L6424_RS10330	COG2233	PERMEase
L6424_RS10335	COG3150	esterase
L6424_RS10340	COG1252	NADH dehydrogenase
L6424_RS10360	COG0393	Putative heavy-metal-binding
L6424_RS10370	COG1648	precorrin-2 dehydrogenase activity
L6424_RS10370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L6424_RS10390	COG4667	esterase of the alpha-beta hydrolase superfamily
L6424_RS10395	COG1619	proteins homologs of microcin C7 resistance protein MccF
L6424_RS10400	COG1368	sulfuric ester hydrolase activity
L6424_RS10410	COG0527	aspartate kinase activity
L6424_RS10415	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L6424_RS10415	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
L6424_RS10420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6424_RS10440	COG0596	Alpha beta hydrolase
L6424_RS10445	COG0346	lactoylglutathione lyase activity
L6424_RS10455	COG0583	DNA-binding transcription factor activity
L6424_RS10460	COG1620	l-lactate permease
L6424_RS10470	COG1139	Iron-sulfur cluster binding protein
L6424_RS10510	COG0577	efflux transmembrane transporter activity
L6424_RS10515	COG1136	(ABC) transporter
L6424_RS10525	COG2814	Major facilitator Superfamily
L6424_RS10545	COG0672	)-iron permease
L6424_RS10575	COG0659	secondary active sulfate transmembrane transporter activity
L6424_RS10600	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L6424_RS10620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L6424_RS10625	COG0840	transmembrane signaling receptor activity
L6424_RS10635	COG2201	protein-glutamate methylesterase activity
L6424_RS10645	COG0835	chemotaxis
L6424_RS10650	COG0840	transmembrane signaling receptor activity
L6424_RS10655	COG2198	Histidine kinase
L6424_RS10655	COG0643	Histidine kinase
L6424_RS10660	COG0643	Histidine kinase
L6424_RS10660	COG2198	Histidine kinase
L6424_RS10670	COG0745	RESPONSE REGULATOR receiver
L6424_RS10675	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
L6424_RS10680	COG0437	4 iron, 4 sulfur cluster binding
L6424_RS10685	COG5557	Pfam Polysulphide reductase, NrfD
L6424_RS10690	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
L6424_RS10695	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
L6424_RS10700	COG1773	rubredoxin
L6424_RS10710	COG0601	transmembrane transport
L6424_RS10715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6424_RS10725	COG3842	ATPase activity
L6424_RS10730	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
L6424_RS10740	COG0375	protein maturation
L6424_RS10745	COG0309	Hydrogenase expression formation protein (HypE)
L6424_RS10755	COG0298	carbon dioxide binding
L6424_RS10760	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
L6424_RS10770	COG1921	L-seryl-tRNASec selenium transferase activity
L6424_RS10780	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
L6424_RS10790	COG3260	NADH ubiquinone oxidoreductase 20
L6424_RS10795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6424_RS10800	COG3261	NADH dehydrogenase
L6424_RS10800	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
L6424_RS10805	COG0650	Formate hydrogenlyase subunit 4
L6424_RS10810	COG0651	ATP synthesis coupled electron transport
L6424_RS10815	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
L6424_RS10820	COG3158	transport of potassium into the cell
L6424_RS10835	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
L6424_RS10865	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L6424_RS10870	COG0326	Molecular chaperone. Has ATPase activity
L6424_RS10875	COG0563	adenylate kinase activity
L6424_RS10880	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L6424_RS10890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6424_RS10905	COG5001	Diguanylate cyclase
L6424_RS10905	COG3300	MHYT domain
L6424_RS10910	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L6424_RS10930	COG1021	2,3-dihydroxybenzoate-AMP ligase
L6424_RS10935	COG3433	isochorismatase activity
L6424_RS10935	COG1535	isochorismatase
L6424_RS10940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L6424_RS10945	COG1028	Short-chain dehydrogenase reductase Sdr
L6424_RS10955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L6424_RS10960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6424_RS10970	COG1120	ATPase activity
L6424_RS10975	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6424_RS10980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6424_RS10985	COG4771	TonB-dependent receptor
L6424_RS11025	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
L6424_RS11030	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L6424_RS11035	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L6424_RS11050	COG1570	exodeoxyribonuclease VII activity
L6424_RS11055	COG0697	spore germination
L6424_RS11075	COG3158	transport of potassium into the cell
L6424_RS11080	COG0516	GMP reductase activity
L6424_RS11080	COG0517	IMP dehydrogenase activity
L6424_RS11085	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L6424_RS11085	COG0519	Catalyzes the synthesis of GMP from XMP
L6424_RS11135	COG2062	phosphohistidine phosphatase, SixA
L6424_RS11145	COG0697	spore germination
L6424_RS11150	COG4166	transmembrane transport
L6424_RS11155	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
L6424_RS11160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L6424_RS11170	COG4591	ABC-type transport system involved in lipoprotein release permease component
L6424_RS11175	COG1136	(ABC) transporter
L6424_RS11180	COG4591	ABC-type transport system involved in lipoprotein release permease component
L6424_RS11185	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
L6424_RS11195	COG0544	peptidyl-prolyl cis-trans isomerase activity
L6424_RS11200	COG0740	serine-type endopeptidase activity
L6424_RS11205	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L6424_RS11210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L6424_RS11215	COG0776	regulation of translation
L6424_RS11220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6424_RS11225	COG0488	(ABC) transporter
L6424_RS11230	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6424_RS11235	COG3162	membrane
L6424_RS11250	COG1024	Enoyl-CoA hydratase
L6424_RS11280	COG1115	amino acid carrier protein
L6424_RS11290	COG3228	Belongs to the MtfA family
L6424_RS11295	COG1584	GPR1 FUN34 yaaH family protein
L6424_RS11330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L6424_RS11335	COG1960	acyl-CoA dehydrogenase activity
L6424_RS11345	COG1960	acyl-CoA dehydrogenase activity
L6424_RS11350	COG1024	Enoyl-CoA hydratase
L6424_RS11355	COG1024	Enoyl-CoA hydratase
L6424_RS11365	COG1028	Short-chain dehydrogenase reductase Sdr
L6424_RS11375	COG0730	response to heat
L6424_RS11395	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L6424_RS11425	COG2003	Belongs to the UPF0758 family
L6424_RS11475	COG5001	Diguanylate cyclase
L6424_RS11475	COG3300	MHYT domain
L6424_RS11480	COG0583	DNA-binding transcription factor activity
L6424_RS11485	COG2723	6-phospho-beta-galactosidase activity
L6424_RS11490	COG5001	Diguanylate cyclase
L6424_RS11490	COG3300	MHYT domain
L6424_RS11500	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
L6424_RS11510	COG0583	DNA-binding transcription factor activity
L6424_RS11525	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
L6424_RS11530	COG0673	inositol 2-dehydrogenase activity
L6424_RS11535	COG0583	DNA-binding transcription factor activity
L6424_RS11545	COG1560	Kdo2-lipid A biosynthetic process
L6424_RS11550	COG1560	Kdo2-lipid A biosynthetic process
L6424_RS11575	COG0417	DNA replication proofreading
L6424_RS11605	COG0534	Mate efflux family protein
L6424_RS11615	COG0307	riboflavin synthase, alpha
L6424_RS11625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L6424_RS11630	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
L6424_RS11635	COG0697	spore germination
L6424_RS11640	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L6424_RS11680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6424_RS11685	COG3099	Belongs to the UPF0263 family
L6424_RS11690	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
L6424_RS11695	COG2894	cell division
L6424_RS11700	COG0850	regulation of cytokinetic process
L6424_RS11705	COG3100	YcgL domain-containing protein
L6424_RS11710	COG2951	lytic endotransglycosylase activity
L6424_RS11715	COG1760	l-serine dehydratase
L6424_RS11720	COG1760	l-serine dehydratase
L6424_RS11725	COG3123	guanosine phosphorylase activity
L6424_RS11745	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
L6424_RS11750	COG2067	long-chain fatty acid transport protein
L6424_RS11765	COG1595	DNA-templated transcription, initiation
L6424_RS11795	COG0714	Associated with various cellular activities
L6424_RS11800	COG0183	Belongs to the thiolase family
L6424_RS11805	COG1250	3-hydroxyacyl-CoA dehydrogenase
L6424_RS11805	COG1024	Enoyl-CoA hydratase
L6424_RS11825	COG3829	transcription factor binding
L6424_RS11830	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L6424_RS11835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L6424_RS11840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L6424_RS11850	COG0549	Belongs to the carbamate kinase family
L6424_RS11855	COG0697	spore germination
L6424_RS11860	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
L6424_RS11860	COG3608	succinylglutamate desuccinylase aspartoacylase
L6424_RS11865	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L6424_RS11870	COG2068	MobA-Related Protein
L6424_RS11875	COG0493	'glutamate synthase
L6424_RS11875	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L6424_RS11880	COG0402	S-adenosylhomocysteine deaminase activity
L6424_RS11885	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L6424_RS11890	COG2080	2 iron, 2 sulfur cluster binding
L6424_RS11890	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L6424_RS11895	COG2233	PERMEase
L6424_RS11900	COG0402	S-adenosylhomocysteine deaminase activity
L6424_RS11905	COG2252	PERMEase
L6424_RS11910	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L6424_RS11915	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L6424_RS11920	COG2080	2 iron, 2 sulfur cluster binding
L6424_RS11930	COG3134	Outer membrane lipoprotein
L6424_RS11940	COG1288	antiporter activity
L6424_RS11945	COG0318	PFAM AMP-dependent synthetase and ligase
L6424_RS11955	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L6424_RS11955	COG0140	phosphoribosyl-ATP diphosphatase activity
L6424_RS11960	COG0107	imidazoleglycerol-phosphate synthase activity
L6424_RS11965	COG0784	Response regulator, receiver
L6424_RS11965	COG2198	Histidine kinase
L6424_RS11965	COG2205	protein histidine kinase activity
L6424_RS11970	COG2199	diguanylate cyclase activity
L6424_RS11975	COG3437	response regulator, receiver
L6424_RS11980	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L6424_RS11985	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L6424_RS11990	COG0131	Imidazoleglycerol-phosphate dehydratase
L6424_RS11990	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L6424_RS11995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L6424_RS12000	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L6424_RS12005	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L6424_RS12015	COG1199	ATP-dependent helicase activity
L6424_RS12020	COG1214	PFAM Peptidase M22, glycoprotease
L6424_RS12030	COG0596	Alpha beta hydrolase
L6424_RS12030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L6424_RS12030	COG2226	methyltransferase
L6424_RS12035	COG0318	PFAM AMP-dependent synthetase and ligase
L6424_RS12040	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
L6424_RS12055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L6424_RS12060	COG2832	Protein of unknown function (DUF454)
L6424_RS12065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L6424_RS12075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L6424_RS12090	COG0617	tRNA 3'-terminal CCA addition
L6424_RS12090	COG0517	IMP dehydrogenase activity
L6424_RS12090	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L6424_RS12095	COG1643	Atp-dependent helicase
L6424_RS12105	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L6424_RS12115	COG3437	response regulator, receiver
L6424_RS12120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6424_RS12125	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
L6424_RS12130	COG0709	Synthesizes selenophosphate from selenide and ATP
L6424_RS12145	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L6424_RS12165	COG1254	Belongs to the acylphosphatase family
L6424_RS12170	COG0625	glutathione transferase activity
L6424_RS12175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6424_RS12175	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6424_RS12180	COG0489	protein tyrosine kinase activity
L6424_RS12185	COG0572	uridine kinase
L6424_RS12190	COG0717	Belongs to the dCTP deaminase family
L6424_RS12195	COG0306	phosphate transporter
L6424_RS12285	COG1530	ribonuclease E activity
L6424_RS12290	COG0564	pseudouridine synthase activity
L6424_RS12295	COG0546	phosphoglycolate phosphatase activity
L6424_RS12300	COG0424	maF-like protein
L6424_RS12305	COG2814	Major facilitator Superfamily
L6424_RS12320	COG1399	metal-binding, possibly nucleic acid-binding protein
L6424_RS12325	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L6424_RS12330	COG0416	fatty acid biosynthetic process
L6424_RS12335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6424_RS12345	COG1028	Short-chain dehydrogenase reductase Sdr
L6424_RS12350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6424_RS12355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L6424_RS12360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6424_RS12365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L6424_RS12370	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L6424_RS12375	COG0470	DNA polymerase III
L6424_RS12380	COG0084	hydrolase, TatD family'
L6424_RS12405	COG2801	Transposase and inactivated derivatives
L6424_RS12415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L6424_RS12415	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
L6424_RS12420	COG3008	intermembrane lipid transfer
L6424_RS12425	COG2995	paraquat-inducible protein a
L6424_RS12435	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L6424_RS12440	COG0372	Belongs to the citrate synthase family
L6424_RS12485	COG4221	oxidoreductase activity
L6424_RS12495	COG3141	response to X-ray
L6424_RS12505	COG1067	ATP-dependent peptidase activity
L6424_RS12510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L6424_RS12525	COG0488	(ABC) transporter
L6424_RS12535	COG0116	Belongs to the methyltransferase superfamily
L6424_RS12535	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L6424_RS12550	COG0167	dihydroorotate dehydrogenase activity
L6424_RS12555	COG2902	Dehydrogenase
L6424_RS12565	COG0308	aminopeptidase N
L6424_RS12575	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
L6424_RS12580	COG1956	GAF domain-containing protein
L6424_RS12590	COG3278	Belongs to the heme-copper respiratory oxidase family
L6424_RS12605	COG2010	Cytochrome c
L6424_RS12630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6424_RS12635	COG0589	response to stress
L6424_RS12640	COG0037	tRNA processing
L6424_RS12660	COG1869	D-ribose catabolic process
L6424_RS12665	COG1129	ABC transporter
L6424_RS12670	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6424_RS12675	COG1879	ABC-type sugar transport system periplasmic component
L6424_RS12680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6424_RS12685	COG1609	Transcriptional regulator
L6424_RS12690	COG5001	Diguanylate cyclase
L6424_RS12690	COG3300	MHYT domain
L6424_RS12720	COG0776	regulation of translation
L6424_RS12725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6424_RS12725	COG0072	phenylalanine-tRNA ligase activity
L6424_RS12730	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L6424_RS12735	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L6424_RS12740	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L6424_RS12745	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L6424_RS12750	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L6424_RS12775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L6424_RS12785	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L6424_RS12790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L6424_RS12795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L6424_RS12800	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
L6424_RS12805	COG3313	Fe-S protein
L6424_RS12810	COG2942	2-epimerase
L6424_RS12815	COG3716	PTS system mannose fructose sorbose family IID component
L6424_RS12825	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6424_RS12825	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6424_RS12840	COG1609	Transcriptional regulator
L6424_RS12845	COG2140	Oxalate decarboxylase
L6424_RS12850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6424_RS12850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6424_RS12850	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L6424_RS12855	COG1105	Belongs to the carbohydrate kinase PfkB family
L6424_RS12860	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6424_RS12860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6424_RS12865	COG1609	Transcriptional regulator
L6424_RS12870	COG0814	amino acid
L6424_RS12880	COG5654	RES domain protein
L6424_RS12885	COG0513	Belongs to the DEAD box helicase family
L6424_RS12895	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L6424_RS12900	COG2890	protein-(glutamine-N5) methyltransferase activity
L6424_RS12905	COG2840	Smr protein MutS2
L6424_RS12915	COG3706	GGDEF domain
L6424_RS12920	COG0588	phosphoglycerate mutase activity
L6424_RS12950	COG2824	Alkylphosphonate utilization operon protein PhnA
L6424_RS12960	COG0384	phenazine biosynthesis protein PhzF
L6424_RS12990	COG0242	peptide deformylase activity
L6424_RS13010	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
L6424_RS13015	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
L6424_RS13025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L6424_RS13030	COG1434	Gram-negative-bacterium-type cell wall biogenesis
L6424_RS13040	COG0205	6-phosphofructokinase activity
L6424_RS13045	COG1473	amidohydrolase
L6424_RS13050	COG1011	Hydrolase
L6424_RS13055	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L6424_RS13110	COG3593	DNA synthesis involved in DNA repair
L6424_RS13125	COG0583	DNA-binding transcription factor activity
L6424_RS13130	COG0730	response to heat
L6424_RS13135	COG3148	PFAM DTW domain containing protein
L6424_RS13145	COG1181	Belongs to the D-alanine--D-alanine ligase family
L6424_RS13155	COG0386	Belongs to the glutathione peroxidase family
L6424_RS13160	COG0513	Belongs to the DEAD box helicase family
L6424_RS13175	COG1742	UPF0060 membrane protein
L6424_RS13205	COG2329	Antibiotic biosynthesis monooxygenase
L6424_RS13210	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
L6424_RS13230	COG3243	poly(R)-hydroxyalkanoic acid synthase
L6424_RS13240	COG2501	S4 domain
L6424_RS13250	COG1132	(ABC) transporter
L6424_RS13255	COG1132	(ABC) transporter
L6424_RS13265	COG3118	belongs to the thioredoxin family
L6424_RS13270	COG0471	metal ion transport
L6424_RS13275	COG0058	SHG alpha-glucan phosphorylase activity
L6424_RS13305	COG0814	amino acid
L6424_RS13310	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
L6424_RS13315	COG0514	ATP-dependent DNA helicase (RecQ)
L6424_RS13320	COG2766	serine protein kinase
L6424_RS13330	COG2719	SpoVR family
L6424_RS13335	COG2186	Transcriptional regulator
L6424_RS13340	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L6424_RS13345	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
L6424_RS13350	COG0586	Pfam SNARE associated Golgi protein
L6424_RS13360	COG0556	nucleotide-excision repair
L6424_RS13370	COG0569	domain protein
L6424_RS13370	COG2985	domain, Protein
L6424_RS13375	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
L6424_RS13395	COG4565	transcriptional regulatory protein
L6424_RS13400	COG3290	protein histidine kinase activity
L6424_RS13405	COG1846	Transcriptional regulator
L6424_RS13405	COG1940	carbohydrate kinase activity
L6424_RS13410	COG0840	transmembrane signaling receptor activity
L6424_RS13415	COG3012	SEC-C Motif Domain Protein
L6424_RS13420	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L6424_RS13425	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
L6424_RS13430	COG0247	lactate metabolic process
L6424_RS13445	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
L6424_RS13450	COG0437	4 iron, 4 sulfur cluster binding
L6424_RS13455	COG3301	Polysulphide reductase, NrfD
L6424_RS13460	COG1138	Cytochrome C-type biogenesis protein
L6424_RS13465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6424_RS13470	COG3088	subunit of a heme lyase
L6424_RS13470	COG4235	cytochrome complex assembly
L6424_RS13475	COG1051	belongs to the nudix hydrolase family
L6424_RS13485	COG3033	Beta-eliminating lyase
L6424_RS13495	COG3046	protein related to deoxyribodipyrimidine photolyase
L6424_RS13500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6424_RS13540	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L6424_RS13555	COG4774	siderophore transport
L6424_RS13560	COG4977	sequence-specific DNA binding
L6424_RS13570	COG0583	DNA-binding transcription factor activity
L6424_RS13575	COG2910	NAD(P)H-binding
L6424_RS13590	COG0612	Peptidase, M16
L6424_RS13595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L6424_RS13605	COG1944	ATP diphosphatase activity
L6424_RS13610	COG2116	formate transmembrane transporter activity
L6424_RS13615	COG1882	Formate acetyltransferase
L6424_RS13620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L6424_RS13625	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L6424_RS13630	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L6424_RS13640	COG1840	ABC-type Fe3 transport system, periplasmic component
L6424_RS13645	COG3842	ATPase activity
L6424_RS13655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6424_RS13660	COG2983	Belongs to the UPF0260 family
L6424_RS13670	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L6424_RS13675	COG0045	succinate-CoA ligase (ADP-forming) activity
L6424_RS13680	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6424_RS13685	COG0567	Dehydrogenase, E1 component
L6424_RS13695	COG1053	succinate dehydrogenase
L6424_RS13700	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L6424_RS13725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L6424_RS13730	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L6424_RS13730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6424_RS13740	COG3069	C4-dicarboxylate transmembrane transporter activity
L6424_RS13755	COG1451	nucleotide metabolic process
L6424_RS13770	COG0254	rRNA binding
L6424_RS13775	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L6424_RS13785	COG0583	DNA-binding transcription factor activity
L6424_RS13795	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6424_RS13805	COG1879	ABC-type sugar transport system periplasmic component
L6424_RS13810	COG1069	ribulokinase activity
L6424_RS13820	COG2160	L-arabinose isomerase activity
L6424_RS13880	COG3188	usher protein
L6424_RS13900	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
L6424_RS13910	COG2197	response regulator
L6424_RS13915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6424_RS13915	COG2205	protein histidine kinase activity
L6424_RS13925	COG2925	Exonuclease
L6424_RS13935	COG3345	alpha-galactosidase
L6424_RS13940	COG1380	Effector of murein hydrolase LrgA
L6424_RS13945	COG1346	cytolysis
L6424_RS13950	COG0295	cytidine deaminase activity
L6424_RS13955	COG1022	Amp-dependent synthetase and ligase
L6424_RS13970	COG0861	Integral membrane protein TerC family
L6424_RS13975	COG2885	chlorophyll binding
L6424_RS13980	COG2199	diguanylate cyclase activity
L6424_RS13995	COG2154	pterin-4-alpha-carbinolamine dehydratase
L6424_RS14005	COG3768	UPF0283 membrane protein
L6424_RS14010	COG3106	COG3106 Predicted ATPase
L6424_RS14025	COG1842	Phage shock protein A
L6424_RS14030	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
L6424_RS14040	COG4168	peptide transport system, permease
L6424_RS14045	COG4171	peptide transport system, permease
L6424_RS14055	COG4172	Belongs to the ABC transporter superfamily
L6424_RS14065	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L6424_RS14070	COG1286	toxin biosynthetic process
L6424_RS14075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L6424_RS14080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L6424_RS14085	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L6424_RS14090	COG0531	amino acid
L6424_RS14090	COG1674	ftsk spoiiie
L6424_RS14100	COG0686	Belongs to the AlaDH PNT family
L6424_RS14105	COG0492	ferredoxin-NADP+ reductase activity
L6424_RS14110	COG3706	GGDEF domain
L6424_RS14115	COG3134	Outer membrane lipoprotein
L6424_RS14120	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L6424_RS14125	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
L6424_RS14130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L6424_RS14135	COG0542	response to heat
L6424_RS14140	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L6424_RS14145	COG1278	Cold shock
L6424_RS14150	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L6424_RS14200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L6424_RS14235	COG1435	thymidine kinase activity
L6424_RS14240	COG1757	Na H antiporter
L6424_RS14245	COG2916	Histone family protein nucleoid-structuring protein H-NS
L6424_RS14250	COG2096	Adenosyltransferase
L6424_RS14255	COG3530	Putative quorum-sensing-regulated virulence factor
L6424_RS14260	COG0602	queuosine metabolic process
L6424_RS14265	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L6424_RS14285	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
L6424_RS14295	COG0776	regulation of translation
L6424_RS14300	COG0539	negative regulation of cytoplasmic translation
L6424_RS14305	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L6424_RS14310	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L6424_RS14320	COG0583	DNA-binding transcription factor activity
L6424_RS14350	COG0778	Nitroreductase
L6424_RS14355	COG3300	MHYT domain
L6424_RS14355	COG5001	Diguanylate cyclase
L6424_RS14365	COG0583	DNA-binding transcription factor activity
L6424_RS14370	COG3437	response regulator, receiver
L6424_RS14395	COG4989	oxidoreductase activity
L6424_RS14400	COG0724	RNA recognition motif
L6424_RS14420	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L6424_RS14435	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6424_RS14440	COG1360	Flagellar Motor Protein
L6424_RS14445	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6424_RS14450	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6424_RS14455	COG0649	NAD binding
L6424_RS14455	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6424_RS14470	COG1034	ATP synthesis coupled electron transport
L6424_RS14475	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L6424_RS14480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6424_RS14485	COG0839	Belongs to the complex I subunit 6 family
L6424_RS14490	COG0713	ATP synthesis coupled electron transport
L6424_RS14500	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6424_RS14505	COG1007	ATP synthesis coupled electron transport
L6424_RS14520	COG2199	diguanylate cyclase activity
L6424_RS14520	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
L6424_RS14525	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L6424_RS14525	COG0047	phosphoribosylformylglycinamidine synthase activity
L6424_RS14530	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
L6424_RS14535	COG1645	bacterial-type flagellum-dependent swarming motility
L6424_RS14540	COG1160	GTP binding
L6424_RS14545	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L6424_RS14550	COG2976	Protein conserved in bacteria
L6424_RS14555	COG0124	histidyl-tRNA synthetase
L6424_RS14560	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L6424_RS14575	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L6424_RS14580	COG0105	UTP biosynthetic process
L6424_RS14585	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L6424_RS14595	COG0633	Ferredoxin
L6424_RS14600	COG0443	Heat shock 70 kDa protein
L6424_RS14605	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
L6424_RS14615	COG0822	iron-sulfur transferase activity
L6424_RS14620	COG1104	cysteine desulfurase activity
L6424_RS14640	COG3154	lipid carrier protein
L6424_RS14645	COG0826	peptidase U32
L6424_RS14650	COG0826	peptidase U32
L6424_RS14665	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6424_RS14670	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6424_RS14675	COG1862	Preprotein translocase
L6424_RS14680	COG0343	queuine tRNA-ribosyltransferase activity
L6424_RS14685	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
L6424_RS14690	COG0517	IMP dehydrogenase activity
L6424_RS14700	COG3634	alkyl hydroperoxide reductase activity
L6424_RS14720	COG1393	Belongs to the ArsC family
L6424_RS14725	COG0798	PFAM Bile acid sodium symporter
L6424_RS14740	COG0640	Transcriptional regulator
L6424_RS14755	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L6424_RS14755	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L6424_RS14760	COG0509	glycine decarboxylation via glycine cleavage system
L6424_RS14765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L6424_RS14770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L6424_RS14775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L6424_RS14795	COG2814	Major facilitator Superfamily
L6424_RS14800	COG0625	glutathione transferase activity
L6424_RS14810	COG0483	inositol monophosphate 1-phosphatase activity
L6424_RS14830	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L6424_RS14870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L6424_RS14875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L6424_RS14890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6424_RS14890	COG0301	tRNA thio-modification
L6424_RS14900	COG4953	penicillin-binding protein 1C
L6424_RS14905	COG2373	Large extracellular alpha-helical protein
L6424_RS14910	COG0446	pyridine nucleotide-disulphide oxidoreductase
L6424_RS14920	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L6424_RS14980	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L6424_RS15020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6424_RS15030	COG2431	L-lysine efflux transmembrane transporter activity
L6424_RS15035	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L6424_RS15040	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
L6424_RS15055	COG1393	Belongs to the ArsC family
L6424_RS15065	COG4783	chaperone-mediated protein folding
L6424_RS15070	COG0425	Belongs to the sulfur carrier protein TusA family
L6424_RS15095	COG3842	ATPase activity
L6424_RS15100	COG3833	ABC-type maltose transport systems, permease component
L6424_RS15105	COG1175	transmembrane transport
L6424_RS15115	COG3081	Nucleoid-associated protein
L6424_RS15120	COG3082	Protein of unknown function (DUF1414)
L6424_RS15125	COG3083	sulfuric ester hydrolase activity
L6424_RS15130	COG4771	TonB-dependent receptor
L6424_RS15135	COG1770	oligopeptidase
L6424_RS15155	COG4574	serine-type endopeptidase inhibitor activity
L6424_RS15160	COG3085	chromosome segregation
L6424_RS15165	COG0583	DNA-binding transcription factor activity
L6424_RS15170	COG1605	Chorismate mutase
L6424_RS15170	COG0287	Prephenate dehydrogenase
L6424_RS15175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L6424_RS15180	COG0584	glycerophosphoryl diester phosphodiesterase
L6424_RS15195	COG1349	DNA-binding transcription factor activity
L6424_RS15200	COG2271	Major facilitator Superfamily
L6424_RS15205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L6424_RS15210	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L6424_RS15215	COG0583	DNA-binding transcription factor activity
L6424_RS15245	COG0656	L-ascorbic acid biosynthetic process
L6424_RS15250	COG2814	Major facilitator Superfamily
L6424_RS15260	COG1294	oxidase, subunit
L6424_RS15265	COG1271	oxidase subunit
L6424_RS15270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6424_RS15275	COG2979	Protein of unknown function (DUF533)
L6424_RS15305	COG2271	Major facilitator Superfamily
L6424_RS15310	COG0583	DNA-binding transcription factor activity
L6424_RS15320	COG2807	transmembrane transport
L6424_RS15325	COG1187	pseudouridine synthase activity
L6424_RS15340	COG0346	lactoylglutathione lyase activity
L6424_RS15350	COG1403	HNH endonuclease
L6424_RS15365	COG3681	Belongs to the UPF0597 family
L6424_RS15375	COG0814	amino acid
L6424_RS15395	COG1166	arginine decarboxylase activity
L6424_RS15400	COG2195	Cleaves the N-terminal amino acid of tripeptides
L6424_RS15430	COG0583	DNA-binding transcription factor activity
L6424_RS15440	COG2759	Belongs to the formate--tetrahydrofolate ligase family
L6424_RS15445	COG0840	transmembrane signaling receptor activity
L6424_RS15450	COG0302	gtp cyclohydrolase
L6424_RS15460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6424_RS15465	COG2267	carboxylic ester hydrolase activity
L6424_RS15470	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L6424_RS15485	COG0314	molybdopterin synthase activity
L6424_RS15490	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
L6424_RS15495	COG0315	cyclic pyranopterin monophosphate synthase activity
L6424_RS15500	COG0521	Mo-molybdopterin cofactor biosynthetic process
L6424_RS15505	COG3005	denitrification pathway
L6424_RS15515	COG0348	domain, Protein
L6424_RS15520	COG0437	4 iron, 4 sulfur cluster binding
L6424_RS15525	COG0243	molybdopterin cofactor binding
L6424_RS15535	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
L6424_RS15535	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L6424_RS15540	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L6424_RS15545	COG3850	Histidine kinase
L6424_RS15550	COG2197	response regulator
L6424_RS15580	COG0121	glutamine amidotransferase
L6424_RS15585	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L6424_RS15590	COG1960	acyl-CoA dehydrogenase activity
L6424_RS15595	COG3437	response regulator, receiver
L6424_RS15595	COG0784	Response regulator, receiver
L6424_RS15610	COG0328	RNA-DNA hybrid ribonuclease activity
L6424_RS15615	COG2226	methyltransferase
L6424_RS15620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6424_RS15625	COG0741	lytic transglycosylase activity
L6424_RS15625	COG1388	LysM domain
L6424_RS15630	COG3021	interspecies interaction between organisms
L6424_RS15640	COG1607	acyl-coa hydrolase
L6424_RS15655	COG0741	lytic transglycosylase activity
L6424_RS15665	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L6424_RS15685	COG2911	Protein conserved in bacteria
L6424_RS15690	COG0729	surface antigen
L6424_RS15700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6424_RS15705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6424_RS15715	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L6424_RS15725	COG4134	Bacterial extracellular solute-binding protein
L6424_RS15735	COG4136	ATPase activity
L6424_RS15740	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L6424_RS15745	COG2951	lytic endotransglycosylase activity
L6424_RS15760	COG1846	Transcriptional regulator
L6424_RS15770	COG0033	Phosphoglucomutase
L6424_RS15775	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
L6424_RS15780	COG0596	Alpha beta hydrolase
L6424_RS15795	COG0716	FMN binding
L6424_RS15805	COG0735	belongs to the Fur family
L6424_RS15810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L6424_RS15820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6424_RS15820	COG2190	(PTS) system
L6424_RS15820	COG1263	PTS System
L6424_RS15830	COG0363	glucosamine-6-phosphate deaminase activity
L6424_RS15835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L6424_RS15840	COG1940	carbohydrate kinase activity
L6424_RS15840	COG1846	Transcriptional regulator
L6424_RS15845	COG2194	sulfuric ester hydrolase activity
L6424_RS15850	COG0217	transcriptional regulatory protein
L6424_RS15855	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L6424_RS15860	COG1801	Protein of unknown function DUF72
L6424_RS15865	COG4106	trans-aconitate 2-methyltransferase activity
L6424_RS15870	COG0500	methyltransferase
L6424_RS15895	COG0450	alkyl hydroperoxide reductase
L6424_RS15900	COG0583	DNA-binding transcription factor activity
L6424_RS15910	COG0791	NLP P60 protein
L6424_RS15925	COG1309	transcriptional regulator
L6424_RS15965	COG0534	Mate efflux family protein
L6424_RS15985	COG2366	antibiotic biosynthetic process
L6424_RS15990	COG0674	pyruvate-flavodoxin oxidoreductase activity
L6424_RS15990	COG1013	pyruvate-flavodoxin oxidoreductase activity
L6424_RS15990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L6424_RS15990	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L6424_RS16000	COG0633	Ferredoxin
L6424_RS16000	COG3217	Mosc domain protein beta barrel domain protein
L6424_RS16000	COG0633	Ferredoxin
L6424_RS16000	COG3217	Mosc domain protein beta barrel domain protein
L6424_RS16010	COG0501	Belongs to the peptidase M48B family
L6424_RS16015	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
L6424_RS16020	COG1073	alpha beta
L6424_RS16020	COG2226	methyltransferase
L6424_RS16025	COG0156	8-amino-7-oxononanoate synthase activity
L6424_RS16030	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L6424_RS16050	COG0017	Asparaginyl-tRNA synthetase
L6424_RS16055	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
L6424_RS16065	COG1473	amidohydrolase
L6424_RS16070	COG3069	C4-dicarboxylate transmembrane transporter activity
L6424_RS16085	COG0583	DNA-binding transcription factor activity
L6424_RS16090	COG1393	Belongs to the ArsC family
L6424_RS16095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L6424_RS16100	COG1876	peptidase activity
L6424_RS16110	COG3263	regulation of cellular component size
L6424_RS16130	COG1280	lysine exporter protein (LysE YggA)
L6424_RS16160	COG0564	pseudouridine synthase activity
L6424_RS16170	COG1454	alcohol dehydrogenase
L6424_RS16175	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L6424_RS16180	COG0702	epimerase
L6424_RS16185	COG2914	Belongs to the UPF0125 (RnfH) family
L6424_RS16190	COG2867	negative regulation of translational initiation
L6424_RS16195	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L6424_RS16210	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L6424_RS16215	COG0583	DNA-binding transcription factor activity
L6424_RS16220	COG2610	gluconate transmembrane transporter activity
L6424_RS16225	COG3048	D-serine ammonia-lyase activity
L6424_RS16235	COG0538	isocitrate dehydrogenase activity
L6424_RS16240	COG2207	Transcriptional regulator
L6424_RS16260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6424_RS16275	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L6424_RS16280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6424_RS16280	COG1263	PTS System
L6424_RS16285	COG1609	Transcriptional regulator
L6424_RS16290	COG1902	pentaerythritol trinitrate reductase activity
L6424_RS16290	COG0446	pyridine nucleotide-disulphide oxidoreductase
L6424_RS16295	COG0789	Transcriptional regulator
L6424_RS16305	COG0456	acetyltransferase
L6424_RS16315	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L6424_RS16340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6424_RS16340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6424_RS16340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6424_RS16355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6424_RS16355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6424_RS16355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6424_RS16365	COG1187	pseudouridine synthase activity
L6424_RS16375	COG0482	sulfurtransferase activity
L6424_RS16380	COG2915	High frequency lysogenization protein hflD homolog
L6424_RS16385	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L6424_RS16390	COG2850	peptidyl-arginine hydroxylation
L6424_RS16395	COG3153	acetyltransferase
L6424_RS16405	COG0625	glutathione transferase activity
L6424_RS16410	COG0259	pyridoxamine-phosphate oxidase activity
L6424_RS16425	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L6424_RS16425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L6424_RS16430	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L6424_RS16445	COG4235	cytochrome complex assembly
L6424_RS16445	COG3088	subunit of a heme lyase
L6424_RS16450	COG3088	subunit of a heme lyase
L6424_RS16450	COG4235	cytochrome complex assembly
L6424_RS16455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6424_RS16460	COG1138	Cytochrome C-type biogenesis protein
L6424_RS16465	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
L6424_RS16470	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6424_RS16475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6424_RS16480	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6424_RS16495	COG0835	chemotaxis
L6424_RS16505	COG1192	Involved in chromosome partitioning
L6424_RS16510	COG1360	Flagellar Motor Protein
L6424_RS16515	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6424_RS16520	COG2201	protein-glutamate methylesterase activity
L6424_RS16525	COG0643	Histidine kinase
L6424_RS16525	COG0784	Response regulator, receiver
L6424_RS16525	COG2198	Histidine kinase
L6424_RS16530	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
L6424_RS16555	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L6424_RS16565	COG1684	flagellar biosynthetic protein fliR
L6424_RS16620	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6424_RS16630	COG1677	Flagellar hook-basal body complex protein FliE
L6424_RS16645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L6424_RS16655	COG3064	Membrane
L6424_RS16655	COG1073	alpha beta
L6424_RS16655	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
L6424_RS16660	COG2994	toxin metabolic process
L6424_RS16670	COG2274	protein secretion by the type I secretion system
L6424_RS16680	COG2274	protein secretion by the type I secretion system
L6424_RS16700	COG1737	Transcriptional regulator
L6424_RS16705	COG0469	pyruvate kinase activity
L6424_RS16715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6424_RS16720	COG1960	acyl-CoA dehydrogenase activity
L6424_RS16730	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L6424_RS16780	COG4735	regulation of single-species biofilm formation
L6424_RS16845	COG0243	molybdopterin cofactor binding
L6424_RS16850	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L6424_RS16855	COG0583	DNA-binding transcription factor activity
L6424_RS16890	COG1454	alcohol dehydrogenase
L6424_RS16890	COG1012	belongs to the aldehyde dehydrogenase family
L6424_RS16900	COG1454	alcohol dehydrogenase
L6424_RS16900	COG1012	belongs to the aldehyde dehydrogenase family
L6424_RS16905	COG1882	Formate acetyltransferase
L6424_RS16910	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L6424_RS16920	COG4869	propanediol catabolic process
L6424_RS16945	COG1376	ErfK ybiS ycfS ynhG family protein
L6424_RS16945	COG1388	LysM domain
L6424_RS16960	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
L6424_RS16965	COG0791	NLP P60 protein
L6424_RS16970	COG2091	lysine biosynthetic process via aminoadipic acid
L6424_RS16975	COG3118	belongs to the thioredoxin family
L6424_RS16985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L6424_RS16990	COG0788	formyltetrahydrofolate deformylase activity
L6424_RS17000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6424_RS17020	COG0366	Alpha amylase catalytic
L6424_RS17025	COG0741	lytic transglycosylase activity
L6424_RS17025	COG1196	nuclear chromosome segregation
L6424_RS17025	COG0739	heme binding
L6424_RS17030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L6424_RS17035	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L6424_RS17040	COG0673	inositol 2-dehydrogenase activity
L6424_RS17090	COG1032	radical SAM domain protein
L6424_RS17100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6424_RS17105	COG1566	PFAM secretion protein HlyD family protein
L6424_RS17115	COG1752	Esterase of the alpha-beta hydrolase superfamily
L6424_RS17120	COG0733	neurotransmitter:sodium symporter activity
L6424_RS17150	COG0281	malic enzyme
L6424_RS17160	COG0534	Mate efflux family protein
L6424_RS17175	COG2233	PERMEase
L6424_RS17180	COG0095	Lipoate-protein ligase
L6424_RS17185	COG1115	amino acid carrier protein
L6424_RS17190	COG0019	diaminopimelate decarboxylase activity
L6424_RS17200	COG0678	peroxiredoxin activity
L6424_RS17210	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
L6424_RS17230	COG1131	(ABC) transporter
L6424_RS17235	COG0545	Peptidyl-prolyl cis-trans isomerase
L6424_RS17245	COG3142	Participates in the control of copper homeostasis
L6424_RS17270	COG5002	protein histidine kinase activity
L6424_RS17275	COG0745	RESPONSE REGULATOR receiver
L6424_RS17280	COG0346	lactoylglutathione lyase activity
L6424_RS17285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L6424_RS17290	COG1960	acyl-CoA dehydrogenase activity
L6424_RS17295	COG3284	Transcriptional regulator
L6424_RS17310	COG0697	spore germination
L6424_RS17315	COG4565	transcriptional regulatory protein
L6424_RS17320	COG3290	protein histidine kinase activity
L6424_RS17325	COG0281	malic enzyme
L6424_RS17340	COG1846	Transcriptional regulator
L6424_RS17345	COG1566	PFAM secretion protein HlyD family protein
L6424_RS17375	COG0602	queuosine metabolic process
L6424_RS17380	COG1328	CTP reductase activity
L6424_RS17390	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L6424_RS17395	COG3115	cell septum assembly
L6424_RS17400	COG1196	nuclear chromosome segregation
L6424_RS17410	COG2860	membrane
L6424_RS17420	COG3108	Peptidase M15
L6424_RS17425	COG2989	Protein conserved in bacteria
L6424_RS17440	COG0463	Glycosyl transferase, family 2
L6424_RS17455	COG0366	Alpha amylase catalytic
L6424_RS17490	COG3706	GGDEF domain
L6424_RS17500	COG3590	peptidase
L6424_RS17510	COG0488	(ABC) transporter
L6424_RS17520	COG0531	amino acid
L6424_RS17530	COG1073	alpha beta
L6424_RS17535	COG1073	alpha beta
L6424_RS17550	COG0814	amino acid
L6424_RS17565	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
L6424_RS17570	COG1982	Orn Lys Arg decarboxylase major
L6424_RS17575	COG0531	amino acid
L6424_RS17580	COG3710	Transcriptional regulator
L6424_RS17585	COG0825	malonyl-CoA metabolic process
L6424_RS17595	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L6424_RS17600	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L6424_RS17605	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L6424_RS17610	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L6424_RS17615	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L6424_RS17630	COG0750	zinc metalloprotease
L6424_RS17635	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L6424_RS17640	COG0575	Belongs to the CDS family
L6424_RS17645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L6424_RS17650	COG0233	cytoplasmic translational termination
L6424_RS17655	COG0528	UMP kinase activity
L6424_RS17660	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L6424_RS17665	COG0052	Belongs to the universal ribosomal protein uS2 family
L6424_RS17670	COG0024	Methionine aminopeptidase
L6424_RS17675	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
L6424_RS17680	COG2171	N-acyltransferase activity
L6424_RS17690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6424_RS17690	COG1263	PTS System
L6424_RS17700	COG4580	involved in the transport of maltose and maltodextrins
L6424_RS17710	COG0564	pseudouridine synthase activity
L6424_RS17715	COG3098	single-species biofilm formation
L6424_RS17740	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
L6424_RS17750	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L6424_RS17750	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L6424_RS17765	COG1611	Belongs to the LOG family
L6424_RS17770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6424_RS17775	COG0473	3-isopropylmalate dehydrogenase activity
L6424_RS17785	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
L6424_RS17790	COG2363	Small membrane protein
L6424_RS17800	COG0583	DNA-binding transcription factor activity
L6424_RS17805	COG0840	transmembrane signaling receptor activity
L6424_RS17810	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L6424_RS17825	COG1477	protein flavinylation
L6424_RS17830	COG2871	sodium ion transport
L6424_RS17835	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L6424_RS17840	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L6424_RS17845	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L6424_RS17850	COG1805	sodium ion transport
L6424_RS17855	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L6424_RS17860	COG0271	Belongs to the BolA IbaG family
L6424_RS17865	COG2813	Specifically methylates the guanine in position
L6424_RS17875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L6424_RS17885	COG2211	Major facilitator Superfamily
L6424_RS17890	COG3248	Nucleoside-binding outer membrane protein
L6424_RS17895	COG1666	GTP binding
L6424_RS17900	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L6424_RS17905	COG0693	protein deglycase activity
L6424_RS17935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L6424_RS17935	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L6424_RS17940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L6424_RS17950	COG1151	hydroxylamine reductase activity
L6424_RS17955	COG0783	Belongs to the Dps family
L6424_RS17985	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L6424_RS18000	COG4221	oxidoreductase activity
L6424_RS18010	COG0415	Belongs to the DNA photolyase family
L6424_RS18015	COG0789	Transcriptional regulator
L6424_RS18020	COG3272	Protein of unknown function (DUF1722)
L6424_RS18050	COG0077	Prephenate dehydratase
L6424_RS18050	COG1605	Chorismate mutase
L6424_RS18175	COG2194	sulfuric ester hydrolase activity
L6424_RS18180	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L6424_RS18185	COG5642	Protein of unknown function (DUF2384)
L6424_RS18195	COG2916	Histone family protein nucleoid-structuring protein H-NS
L6424_RS18235	COG3254	rhamnose metabolic process
L6424_RS18245	COG4806	L-rhamnose isomerase
L6424_RS18250	COG1070	Carbohydrate kinase
L6424_RS18255	COG4977	sequence-specific DNA binding
L6424_RS18260	COG1454	alcohol dehydrogenase
L6424_RS18265	COG0235	Class ii aldolase
L6424_RS18275	COG0840	transmembrane signaling receptor activity
L6424_RS18285	COG0300	oxidoreductase activity
L6424_RS18310	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
L6424_RS18335	COG0826	peptidase U32
L6424_RS18340	COG1280	lysine exporter protein (LysE YggA)
L6424_RS18350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6424_RS18355	COG0840	transmembrane signaling receptor activity
L6424_RS18370	COG0643	Histidine kinase
L6424_RS18370	COG2198	Histidine kinase
L6424_RS18380	COG0835	chemotaxis
L6424_RS18385	COG0840	transmembrane signaling receptor activity
L6424_RS18395	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
L6424_RS18400	COG2201	protein-glutamate methylesterase activity
L6424_RS18405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L6424_RS18435	COG2197	response regulator
L6424_RS18445	COG2197	response regulator
L6424_RS18470	COG2203	Gaf domain
L6424_RS18470	COG2200	EAL domain
L6424_RS18470	COG2199	diguanylate cyclase activity
L6424_RS18475	COG0826	peptidase U32
L6424_RS18480	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L6424_RS18490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L6424_RS18495	COG0305	Participates in initiation and elongation during chromosome replication
L6424_RS18505	COG2200	EAL domain
L6424_RS18510	COG0737	Belongs to the 5'-nucleotidase family
L6424_RS18520	COG0737	Belongs to the 5'-nucleotidase family
L6424_RS18540	COG2204	response regulator
L6424_RS18545	COG0545	Peptidyl-prolyl cis-trans isomerase
L6424_RS18560	COG1047	Peptidyl-prolyl cis-trans
L6424_RS18565	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L6424_RS18575	COG0784	Response regulator, receiver
L6424_RS18575	COG0835	chemotaxis
L6424_RS18580	COG0429	hydrolase of the alpha beta-hydrolase fold
L6424_RS18585	COG3706	GGDEF domain
L6424_RS18585	COG2203	Gaf domain
L6424_RS18585	COG4251	negative regulation of phosphorylation
L6424_RS18585	COG5001	Diguanylate cyclase
L6424_RS18590	COG3089	Belongs to the UPF0270 family
L6424_RS18600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L6424_RS18605	COG0463	Glycosyl transferase, family 2
L6424_RS18625	COG0726	polysaccharide deacetylase
L6424_RS18630	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
L6424_RS18635	COG2076	Multidrug Resistance protein
L6424_RS18640	COG2076	Multidrug Resistance protein
L6424_RS18645	COG3954	Phosphoribulokinase
L6424_RS18660	COG1765	OsmC-like protein
L6424_RS18670	COG2226	methyltransferase
L6424_RS18675	COG3397	chitin binding
L6424_RS18690	COG2205	protein histidine kinase activity
L6424_RS18690	COG2202	Pas domain
L6424_RS18700	COG3655	Transcriptional regulator
L6424_RS18705	COG2814	Major facilitator Superfamily
L6424_RS18710	COG4771	TonB-dependent receptor
L6424_RS18730	COG0748	coenzyme F420 binding
L6424_RS18735	COG3721	Heme iron utilization protein
L6424_RS18745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6424_RS18770	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
L6424_RS18775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6424_RS18780	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
L6424_RS18800	COG0741	lytic transglycosylase activity
L6424_RS18805	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L6424_RS18820	COG0488	(ABC) transporter
L6424_RS18830	COG2252	PERMEase
L6424_RS18835	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
L6424_RS18840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L6424_RS18845	COG3178	'Phosphotransferase
L6424_RS18850	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
L6424_RS18860	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
L6424_RS18865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L6424_RS18870	COG2967	ApaG domain
L6424_RS18875	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L6424_RS18885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L6424_RS18890	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
L6424_RS18905	COG0318	PFAM AMP-dependent synthetase and ligase
L6424_RS18910	COG3314	Sporulation integral membrane protein YlbJ
L6424_RS18915	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L6424_RS18920	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L6424_RS18925	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L6424_RS18930	COG0142	geranyltranstransferase activity
L6424_RS18935	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
L6424_RS18940	COG0330	HflC and HflK could
L6424_RS18945	COG0330	HflC and HflK could
L6424_RS18950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L6424_RS18955	COG1923	regulation of RNA biosynthetic process
L6424_RS18960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L6424_RS18965	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L6424_RS18975	COG0802	atpase or kinase
L6424_RS18980	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L6424_RS18980	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L6424_RS18985	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L6424_RS19000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L6424_RS19005	COG2011	ABC-type metal ion transport system permease component
L6424_RS19010	COG1464	Belongs to the NlpA lipoprotein family
L6424_RS19020	COG0840	transmembrane signaling receptor activity
L6424_RS19045	COG5002	protein histidine kinase activity
L6424_RS19045	COG2198	Histidine kinase
L6424_RS19045	COG0784	Response regulator, receiver
L6424_RS19065	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L6424_RS19080	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L6424_RS19085	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
L6424_RS19095	COG2716	regulation of RNA biosynthetic process
L6424_RS19100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L6424_RS19105	COG3013	Belongs to the UPF0304 family
L6424_RS19115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L6424_RS19120	COG0857	belongs to the CobB CobQ family
L6424_RS19120	COG0280	phosphate acetyltransferase
L6424_RS19130	COG0028	Belongs to the TPP enzyme family
L6424_RS19145	COG0671	phosphoesterase, PA-phosphatase related
L6424_RS19155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L6424_RS19160	COG0473	3-isopropylmalate dehydrogenase activity
L6424_RS19165	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L6424_RS19170	COG0066	3-isopropylmalate dehydratase activity
L6424_RS19185	COG4143	(ABC) transporter
L6424_RS19190	COG1178	ABC-type Fe3 transport system permease component
L6424_RS19195	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
L6424_RS19205	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L6424_RS19215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L6424_RS19245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L6424_RS19250	COG0564	pseudouridine synthase activity
L6424_RS19260	COG3300	MHYT domain
L6424_RS19260	COG5001	Diguanylate cyclase
L6424_RS19270	COG0459	protein refolding
L6424_RS19275	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L6424_RS19280	COG0534	Mate efflux family protein
L6424_RS19285	COG3030	protein affecting phage T7 exclusion by the F plasmid
L6424_RS19290	COG1027	Aspartate ammonia-lyase
L6424_RS19295	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
L6424_RS19305	COG0477	Major facilitator Superfamily
L6424_RS19320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6424_RS19325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6424_RS19335	COG0673	inositol 2-dehydrogenase activity
L6424_RS19345	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L6424_RS19350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L6424_RS19355	COG3036	rescue of stalled ribosome
L6424_RS19370	COG0138	bifunctional purine biosynthesis protein purh
L6424_RS19375	COG0151	Belongs to the GarS family
L6424_RS19400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L6424_RS19405	COG0358	DNA primase activity
L6424_RS19410	COG1610	YqeY-like protein
L6424_RS19415	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L6424_RS19420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L6424_RS19435	COG1238	metal cluster binding
L6424_RS19440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L6424_RS19445	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L6424_RS19450	COG0585	pseudouridine synthase activity
L6424_RS19460	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L6424_RS19465	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L6424_RS19470	COG0148	phosphopyruvate hydratase activity
L6424_RS19475	COG0504	CTP synthase activity
L6424_RS19480	COG3956	TIGRFAM MazG family protein
L6424_RS19485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L6424_RS19490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L6424_RS19500	COG4807	Protein conserved in bacteria
L6424_RS19505	COG3023	N-Acetylmuramoyl-L-alanine amidase
L6424_RS19510	COG1349	DNA-binding transcription factor activity
L6424_RS19520	COG2222	sugar isomerase
L6424_RS19525	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6424_RS19535	COG3716	PTS system mannose fructose sorbose family IID component
L6424_RS19540	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6424_RS19545	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L6424_RS19560	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L6424_RS19565	COG1381	Involved in DNA repair and RecF pathway recombination
L6424_RS19575	COG0571	ribonuclease III activity
L6424_RS19580	COG0681	Belongs to the peptidase S26 family
L6424_RS19585	COG0481	GTPase activity
L6424_RS19600	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
L6424_RS19605	COG1595	DNA-templated transcription, initiation
L6424_RS19610	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
L6424_RS19620	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L6424_RS19660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6424_RS19670	COG0126	phosphoglycerate kinase activity
L6424_RS19675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L6424_RS19680	COG1940	carbohydrate kinase activity
L6424_RS19685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L6424_RS19690	COG2816	NAD+ diphosphatase activity
L6424_RS19700	COG4991	sh3 domain protein
L6424_RS19705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6424_RS19720	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L6424_RS19725	COG1028	Short-chain dehydrogenase reductase Sdr
L6424_RS19740	COG1505	serine-type exopeptidase activity
L6424_RS19745	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L6424_RS19750	COG0765	amino acid transport
L6424_RS19755	COG0765	amino acid transport
L6424_RS19760	COG1126	abc transporter atp-binding protein
L6424_RS19765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6424_RS19770	COG0577	efflux transmembrane transporter activity
L6424_RS19770	COG1136	(ABC) transporter
L6424_RS19775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6424_RS19780	COG0745	RESPONSE REGULATOR receiver
L6424_RS19785	COG2205	protein histidine kinase activity
L6424_RS19800	COG2816	NAD+ diphosphatase activity
L6424_RS19835	COG2070	2-Nitropropane dioxygenase
L6424_RS19860	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
L6424_RS19885	COG0513	Belongs to the DEAD box helicase family
L6424_RS19910	COG0154	amidase activity
L6424_RS19915	COG2957	Belongs to the agmatine deiminase family
L6424_RS19930	COG1902	pentaerythritol trinitrate reductase activity
L6424_RS19975	COG0714	Associated with various cellular activities
L6424_RS19985	COG0456	acetyltransferase
L6424_RS19995	COG1022	Amp-dependent synthetase and ligase
L6424_RS20005	COG2918	glutathione biosynthetic process
L6424_RS20010	COG0612	Peptidase, M16
L6424_RS20015	COG1238	metal cluster binding
L6424_RS20040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L6424_RS20045	COG0359	binds to the 23S rRNA
L6424_RS20050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L6424_RS20055	COG0360	Binds together with S18 to 16S ribosomal RNA
L6424_RS20060	COG1914	H( )-stimulated, divalent metal cation uptake system
L6424_RS20080	COG2153	protein acetylation
L6424_RS20090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L6424_RS20095	COG0557	exoribonuclease II activity
L6424_RS20100	COG3706	GGDEF domain
L6424_RS20105	COG1854	S-ribosylhomocysteine lyase activity
L6424_RS20120	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L6424_RS20120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L6424_RS20180	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L6424_RS20185	COG1047	Peptidyl-prolyl cis-trans
L6424_RS20190	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L6424_RS20195	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L6424_RS20200	COG0196	riboflavin kinase activity
L6424_RS20210	COG0728	peptidoglycan biosynthetic process
L6424_RS20215	COG0268	Binds directly to 16S ribosomal RNA
L6424_RS20220	COG0640	Transcriptional regulator
L6424_RS20225	COG0583	DNA-binding transcription factor activity
L6424_RS20235	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L6424_RS20240	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
L6424_RS20245	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L6424_RS20255	COG1051	belongs to the nudix hydrolase family
L6424_RS20260	COG3066	DNA modification
L6424_RS20270	COG0335	large ribosomal subunit rRNA binding
L6424_RS20275	COG0336	Belongs to the RNA methyltransferase TrmD family
L6424_RS20280	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L6424_RS20285	COG0228	four-way junction DNA binding
L6424_RS20290	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L6424_RS20295	COG4137	Cytochrome C assembly protein
L6424_RS20300	COG4536	flavin adenine dinucleotide binding
L6424_RS20310	COG1017	nitric oxide dioxygenase activity
L6424_RS20310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L6424_RS20315	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
L6424_RS20320	COG0039	L-malate dehydrogenase activity
L6424_RS20325	COG4160	amino acid transport
L6424_RS20330	COG4215	(ABC) transporter
L6424_RS20335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6424_RS20340	COG1126	abc transporter atp-binding protein
L6424_RS20345	COG1438	arginine binding
L6424_RS20350	COG2837	iron assimilation
L6424_RS20355	COG3842	ATPase activity
L6424_RS20365	COG1840	ABC-type Fe3 transport system, periplasmic component
L6424_RS20370	COG0347	Belongs to the P(II) protein family
L6424_RS20385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6424_RS20390	COG0583	DNA-binding transcription factor activity
L6424_RS20405	COG1929	Belongs to the glycerate kinase type-1 family
L6424_RS20410	COG2610	gluconate transmembrane transporter activity
L6424_RS20415	COG3835	regulator
L6424_RS20420	COG3112	Uncharacterised protein family (UPF0231)
L6424_RS20435	COG0840	transmembrane signaling receptor activity
L6424_RS20455	COG0513	Belongs to the DEAD box helicase family
L6424_RS20495	COG1448	Aminotransferase
L6424_RS20510	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L6424_RS20515	COG1328	CTP reductase activity
L6424_RS20535	COG4946	Tricorn protease homolog
L6424_RS20535	COG0793	Belongs to the peptidase S41A family
L6424_RS20565	COG0840	transmembrane signaling receptor activity
L6424_RS20570	COG3397	chitin binding
L6424_RS20575	COG0583	DNA-binding transcription factor activity
L6424_RS20580	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L6424_RS20585	COG4208	sulfate ABC transporter
L6424_RS20590	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L6424_RS20610	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L6424_RS20620	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L6424_RS20625	COG3174	membrane
L6424_RS20630	COG0110	maltose O-acetyltransferase activity
L6424_RS20665	COG0165	Argininosuccinate lyase
L6424_RS20675	COG0137	argininosuccinate synthase activity
L6424_RS20685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L6424_RS20690	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L6424_RS20700	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
L6424_RS20710	COG0460	homoserine dehydrogenase
L6424_RS20710	COG0527	aspartate kinase activity
L6424_RS20715	COG0626	cystathionine gamma-synthase activity
L6424_RS20725	COG3708	Transcriptional regulator
L6424_RS20725	COG2207	Transcriptional regulator
L6424_RS20730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6424_RS20735	COG0814	amino acid
L6424_RS20740	COG1218	3'(2'),5'-bisphosphate nucleotidase
L6424_RS20745	COG0494	nUDIX hydrolase
L6424_RS20750	COG1011	Hydrolase
L6424_RS20755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L6424_RS20770	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
L6424_RS20790	COG4795	General secretion pathway protein
L6424_RS20795	COG2165	general secretion pathway protein
L6424_RS20805	COG2165	general secretion pathway protein
L6424_RS20810	COG1459	type II secretion system
L6424_RS20815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L6424_RS20825	COG3031	protein transport across the cell outer membrane
L6424_RS20835	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L6424_RS20840	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
L6424_RS20860	COG0456	acetyltransferase
L6424_RS20865	COG3133	Outer membrane lipoprotein
L6424_RS20880	COG2771	luxR family
L6424_RS20885	COG3916	Acyl-homoserine-lactone synthase
L6424_RS20895	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
L6424_RS20900	COG1309	transcriptional regulator
L6424_RS20910	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6424_RS20910	COG2213	PTS system mannitol-specific
L6424_RS20915	COG0246	Mannitol dehydrogenase
L6424_RS20920	COG3722	fumarate hydratase activity
L6424_RS20925	COG3263	regulation of cellular component size
L6424_RS20950	COG1671	Belongs to the UPF0178 family
L6424_RS20965	COG1988	membrane-bound metal-dependent
L6424_RS20970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6424_RS20975	COG0513	Belongs to the DEAD box helicase family
L6424_RS21005	COG1575	Belongs to the MenA family. Type 1 subfamily
L6424_RS21010	COG1169	isochorismate synthase
L6424_RS21015	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
L6424_RS21020	COG0596	Alpha beta hydrolase
L6424_RS21025	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
L6424_RS21030	COG1441	menaquinone biosynthetic process
L6424_RS21035	COG0318	PFAM AMP-dependent synthetase and ligase
L6424_RS21050	COG3539	Fimbrial protein
L6424_RS21055	COG3121	Chaperone
L6424_RS21060	COG3188	usher protein
L6424_RS21070	COG3539	Fimbrial protein
L6424_RS21080	COG3291	Pkd domain containing protein
L6424_RS21085	COG2949	membrane
L6424_RS21090	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6424_RS21100	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
L6424_RS21105	COG5380	lipid catabolic process
L6424_RS21130	COG2873	o-acetylhomoserine
L6424_RS21140	COG1979	alcohol dehydrogenase
L6424_RS21160	COG4221	oxidoreductase activity
L6424_RS21180	COG1285	pathogenesis
L6424_RS21200	COG1368	sulfuric ester hydrolase activity
L6424_RS21205	COG1522	sequence-specific DNA binding
L6424_RS21215	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
L6424_RS21220	COG1418	mRNA catabolic process
L6424_RS21225	COG1058	Belongs to the CinA family
L6424_RS21225	COG1546	Belongs to the CinA family
L6424_RS21235	COG0842	Transport permease protein
L6424_RS21235	COG1129	ABC transporter
L6424_RS21250	COG0561	phosphatase activity
L6424_RS21255	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L6424_RS21275	COG1011	Hydrolase
L6424_RS21290	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L6424_RS21295	COG0019	diaminopimelate decarboxylase activity
L6424_RS21305	COG1965	Belongs to the frataxin family
L6424_RS21310	COG0400	carboxylic ester hydrolase activity
L6424_RS21315	COG3072	Adenylate cyclase
L6424_RS21320	COG0181	hydroxymethylbilane synthase activity
L6424_RS21330	COG2959	enzyme of heme biosynthesis
L6424_RS21345	COG1494	fructose-1,6-bisphosphatase
L6424_RS21385	COG1733	regulation of RNA biosynthetic process
L6424_RS21405	COG3932	Exopolysaccharide synthesis, ExoD
L6424_RS21410	COG0814	amino acid
L6424_RS21415	COG3706	GGDEF domain
L6424_RS21435	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
L6424_RS21460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L6424_RS21465	COG2022	thiamine diphosphate biosynthetic process
L6424_RS21475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6424_RS21480	COG0352	thiamine-phosphate diphosphorylase activity
L6424_RS21485	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
L6424_RS21505	COG0745	RESPONSE REGULATOR receiver
L6424_RS21510	COG0642	Histidine kinase
L6424_RS21520	COG0189	ligase activity
L6424_RS21550	COG1639	'signal transduction protein
L6424_RS21560	COG2321	neutral zinc metallopeptidase
L6424_RS21565	COG3700	Belongs to the class B bacterial acid phosphatase family
L6424_RS21585	COG1366	Belongs to the anti-sigma-factor antagonist family
L6424_RS21590	COG2172	sigma factor antagonist activity
L6424_RS21595	COG5002	protein histidine kinase activity
L6424_RS21595	COG2205	protein histidine kinase activity
L6424_RS21595	COG0784	Response regulator, receiver
L6424_RS21600	COG3437	response regulator, receiver
L6424_RS21610	COG0477	Major facilitator Superfamily
L6424_RS21625	COG0312	modulator of DNA gyrase
L6424_RS21630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L6424_RS21640	COG3164	Protein of unknown function
L6424_RS21645	COG1530	ribonuclease E activity
L6424_RS21650	COG0424	maF-like protein
L6424_RS21655	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L6424_RS21660	COG1792	Involved in formation and maintenance of cell shape
L6424_RS21665	COG1077	Cell shape determining protein MreB Mrl
L6424_RS21690	COG4968	Prepilin-type N-terminal cleavage methylation domain
L6424_RS21700	COG4969	Belongs to the N-Me-Phe pilin family
L6424_RS21705	COG2165	general secretion pathway protein
L6424_RS21715	COG1459	type II secretion system
L6424_RS21720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L6424_RS21765	COG2200	EAL domain
L6424_RS21765	COG2199	diguanylate cyclase activity
L6424_RS21770	COG2200	EAL domain
L6424_RS21775	COG0387	Pfam Sodium calcium exchanger
L6424_RS21780	COG2986	histidine ammonia-lyase
L6424_RS21785	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
L6424_RS21790	COG0010	Belongs to the arginase family
L6424_RS21795	COG1228	amidohydrolase
L6424_RS21800	COG2188	Transcriptional regulator
L6424_RS21805	COG0288	reversible hydration of carbon dioxide
L6424_RS21815	COG2177	Part of the ABC transporter FtsEX involved in
L6424_RS21820	COG2884	Cell division ATP-binding protein ftsE
L6424_RS21825	COG0552	protein localization to endoplasmic reticulum
L6424_RS21830	COG0742	ribosomal rna small subunit methyltransferase
L6424_RS21855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6424_RS21865	COG0741	lytic transglycosylase activity
L6424_RS21875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L6424_RS21885	COG2095	MarC family integral membrane protein
L6424_RS21895	COG1301	dicarboxylic acid transport
L6424_RS21920	COG3714	YhhN family
L6424_RS21940	COG1770	oligopeptidase
L6424_RS21955	COG4221	oxidoreductase activity
L6424_RS21960	COG0583	DNA-binding transcription factor activity
L6424_RS21965	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6424_RS22010	COG0203	ribosomal protein L17
L6424_RS22015	COG0202	RNA polymerase activity
L6424_RS22020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L6424_RS22025	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L6424_RS22030	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L6424_RS22035	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L6424_RS22040	COG0201	protein transport
L6424_RS22045	COG0200	Binds to the 23S rRNA
L6424_RS22050	COG1841	ribosomal large subunit assembly
L6424_RS22055	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L6424_RS22060	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
L6424_RS22065	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L6424_RS22070	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L6424_RS22075	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L6424_RS22080	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L6424_RS22085	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L6424_RS22090	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L6424_RS22095	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L6424_RS22100	COG0255	Belongs to the universal ribosomal protein uL29 family
L6424_RS22105	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L6424_RS22110	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L6424_RS22115	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L6424_RS22120	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L6424_RS22125	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L6424_RS22130	COG0089	rRNA binding
L6424_RS22135	COG0088	Forms part of the polypeptide exit tunnel
L6424_RS22140	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L6424_RS22145	COG0051	transcription antitermination factor activity, RNA binding
L6424_RS22165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L6424_RS22170	COG2183	response to ionizing radiation
L6424_RS22190	COG0596	Alpha beta hydrolase
L6424_RS22195	COG1040	competence protein
L6424_RS22200	COG0316	Belongs to the HesB IscA family
L6424_RS22200	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
L6424_RS22205	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L6424_RS22210	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
L6424_RS22215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6424_RS22220	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L6424_RS22225	COG4942	peptidase
L6424_RS22235	COG1609	Transcriptional regulator
L6424_RS22240	COG0800	Aldolase
L6424_RS22245	COG0129	dihydroxy-acid dehydratase activity
L6424_RS22250	COG3265	gluconokinase activity
L6424_RS22255	COG2610	gluconate transmembrane transporter activity
L6424_RS22260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6424_RS22265	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L6424_RS22275	COG0456	acetyltransferase
L6424_RS22285	COG1490	D-aminoacyl-tRNA deacylase activity
L6424_RS22290	COG1295	ribonuclease BN
L6424_RS22295	COG1217	gtp-binding protein TYPA
L6424_RS22300	COG0174	glutamine synthetase
L6424_RS22310	COG3852	Histidine kinase
L6424_RS22315	COG2204	response regulator
L6424_RS22320	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L6424_RS22325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L6424_RS22335	COG3078	GTPase activator activity
L6424_RS22345	COG0218	Necessary for normal cell division and for the maintenance of normal septation
L6424_RS22355	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L6424_RS22360	COG0408	coproporphyrinogen oxidase activity
L6424_RS22365	COG0009	L-threonylcarbamoyladenylate synthase
L6424_RS22375	COG0551	DNA topoisomerase type I activity
L6424_RS22380	COG2922	Belongs to the Smg family
L6424_RS22385	COG0758	DNA mediated transformation
L6424_RS22395	COG0242	peptide deformylase activity
L6424_RS22400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L6424_RS22405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L6424_RS22405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L6424_RS22410	COG0569	domain protein
L6424_RS22415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6424_RS22420	COG1322	Protein conserved in bacteria
L6424_RS22440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6424_RS22445	COG0686	Belongs to the AlaDH PNT family
L6424_RS22450	COG0519	Catalyzes the synthesis of GMP from XMP
L6424_RS22450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L6424_RS22475	COG1396	sequence-specific DNA binding
L6424_RS22480	COG1012	belongs to the aldehyde dehydrogenase family
L6424_RS22490	COG2962	Rard protein
L6424_RS22500	COG1280	lysine exporter protein (LysE YggA)
L6424_RS22510	COG2391	methyltransferase activity
L6424_RS22520	COG1280	lysine exporter protein (LysE YggA)
L6424_RS22575	COG0210	DNA helicase
L6424_RS22580	COG1744	ABC transporter substrate-binding protein PnrA-like
L6424_RS22585	COG3845	ABC transporter
L6424_RS22590	COG4603	Belongs to the binding-protein-dependent transport system permease family
L6424_RS22595	COG1079	Belongs to the binding-protein-dependent transport system permease family
L6424_RS22600	COG0583	DNA-binding transcription factor activity
L6424_RS22620	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L6424_RS22625	COG0385	Bile acid
L6424_RS22630	COG0531	amino acid
L6424_RS22635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6424_RS22640	COG0531	amino acid
L6424_RS22645	COG2731	YhcH YjgK YiaL family protein
L6424_RS22650	COG3250	beta-galactosidase activity
L6424_RS22655	COG1609	Transcriptional regulator
L6424_RS22690	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L6424_RS22695	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6424_RS22695	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6424_RS22700	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
L6424_RS22705	COG3074	FtsZ-dependent cytokinesis
L6424_RS22715	COG1045	serine acetyltransferase
L6424_RS22725	COG0745	RESPONSE REGULATOR receiver
L6424_RS22730	COG2205	protein histidine kinase activity
L6424_RS22735	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L6424_RS22740	COG0534	Mate efflux family protein
L6424_RS22755	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L6424_RS22760	COG2937	Belongs to the GPAT DAPAT family
L6424_RS22765	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L6424_RS22770	COG3161	chorismate lyase activity
L6424_RS22775	COG1580	Controls the rotational direction of flagella during chemotaxis
L6424_RS22790	COG0604	alcohol dehydrogenase
L6424_RS22795	COG1609	Transcriptional regulator
L6424_RS22815	COG1519	Transferase
L6424_RS22820	COG0859	PFAM glycosyl transferase family 9
L6424_RS22825	COG0463	Glycosyl transferase, family 2
L6424_RS22830	COG0859	PFAM glycosyl transferase family 9
L6424_RS22835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L6424_RS22840	COG2990	Protein conserved in bacteria
L6424_RS22845	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L6424_RS22855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L6424_RS22860	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L6424_RS22865	COG2003	Belongs to the UPF0758 family
L6424_RS22870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L6424_RS22875	COG0756	dUTP diphosphatase activity
L6424_RS22880	COG1309	transcriptional regulator
L6424_RS22885	COG0668	transmembrane transport
L6424_RS22895	COG0166	Belongs to the GPI family
L6424_RS22900	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L6424_RS22905	COG0583	DNA-binding transcription factor activity
L6424_RS22945	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
L6424_RS22950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6424_RS22955	COG1739	Uncharacterized protein family UPF0029
L6424_RS22960	COG0006	proline dipeptidase activity
L6424_RS22965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6424_RS22970	COG1250	3-hydroxyacyl-CoA dehydrogenase
L6424_RS22970	COG1024	Enoyl-CoA hydratase
L6424_RS22975	COG0183	Belongs to the thiolase family
L6424_RS23000	COG0425	Belongs to the sulfur carrier protein TusA family
L6424_RS23005	COG0251	oxidation-reduction process
L6424_RS23015	COG2885	chlorophyll binding
L6424_RS23025	COG2818	Glycosylase
L6424_RS23030	COG0752	glycyl-tRNA synthetase alpha subunit
L6424_RS23035	COG0751	glycine-tRNA ligase activity
L6424_RS23065	COG0814	amino acid
L6424_RS23070	COG0348	domain, Protein
L6424_RS23080	COG0446	pyridine nucleotide-disulphide oxidoreductase
L6424_RS23085	COG1773	rubredoxin
L6424_RS23085	COG0426	domain, Protein
L6424_RS23090	COG3604	Transcriptional regulator
L6424_RS23095	COG2188	Transcriptional regulator
L6424_RS23110	COG1609	Transcriptional regulator
L6424_RS23150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6424_RS23175	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
L6424_RS23190	COG3118	belongs to the thioredoxin family
L6424_RS23195	COG0513	Belongs to the DEAD box helicase family
L6424_RS23200	COG0248	Ppx GppA phosphatase
L6424_RS23215	COG0742	ribosomal rna small subunit methyltransferase
L6424_RS23235	COG0084	hydrolase, TatD family'
L6424_RS23240	COG0805	protein transport
L6424_RS23245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L6424_RS23255	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L6424_RS23260	COG3165	ubiquinone biosynthetic process from chorismate
L6424_RS23270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L6424_RS23275	COG0402	S-adenosylhomocysteine deaminase activity
L6424_RS23320	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
L6424_RS23325	COG0848	biopolymer transport protein
L6424_RS23330	COG0811	peptide transport
L6424_RS23335	COG0811	peptide transport
L6424_RS23345	COG2771	luxR family
L6424_RS23350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L6424_RS23355	COG1349	DNA-binding transcription factor activity
L6424_RS23360	COG0745	RESPONSE REGULATOR receiver
L6424_RS23365	COG2205	protein histidine kinase activity
L6424_RS23375	COG4452	Inner membrane protein CreD
L6424_RS23380	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L6424_RS23385	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L6424_RS23390	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L6424_RS23395	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L6424_RS23400	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L6424_RS23405	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L6424_RS23410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L6424_RS23420	COG0356	it plays a direct role in the translocation of protons across the membrane
L6424_RS23430	COG1475	DNA binding
L6424_RS23435	COG1192	Involved in chromosome partitioning
L6424_RS23440	COG0357	Ribosomal RNA small subunit methyltransferase G
L6424_RS23445	COG0445	tRNA wobble uridine modification
L6424_RS23450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L6424_RS23455	COG4774	siderophore transport
L6424_RS23460	COG4615	Cyclic peptide transporter
L6424_RS23465	COG1120	ATPase activity
L6424_RS23480	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L6424_RS23485	COG0706	membrane insertase activity
L6424_RS23490	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
L6424_RS23495	COG0594	ribonuclease P activity
L6424_RS23500	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L6424_RS23505	COG1126	abc transporter atp-binding protein
L6424_RS23535	COG1230	cation diffusion facilitator family transporter
L6424_RS23540	COG0640	Transcriptional regulator
L6424_RS23660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella